Table:
0
A
B
C
D
E
F
G
H
1
Enzyme
Location
Substrate
Product
Chromosome
EC
OMIM
Porphyria
2
ALA synthase
Mitochondrion
Glycine , succinyl CoA
δ-Aminolevulinic acid
3p21.1
2.3.1.37
125290
none
3
ALA dehydratase
Cytosol
δ-Aminolevulinic acid
Porphobilinogen
9q34
4.2.1.24
125270
ALA-Dehydratase deficiency
4
PBG deaminase
Cytosol
Porphobilinogen
Hydroxymethyl bilane
11q23.3
2.5.1.61
176000
acute intermittent porphyria
5
Uroporphyrinogen III synthase
Cytosol
Hydroxymethyl bilane
Uroporphyrinogen III
10q25.2-q26.3
4.2.1.75
606938
congenital erythropoietic porphyria
6
Uroporphyrinogen III decarboxylase
Cytosol
Uroporphyrinogen III
Coproporphyrinogen III
1p34
4.1.1.37
176100
porphyria cutanea tarda
7
Coproporphyrinogen III oxidase
Mitochondrion
Coproporphyrinogen III
Protoporphyrinogen IX
3q12
1.3.3.3
121300
coproporphyria
8
Protoporphyrinogen oxidase
Mitochondrion
Protoporphyrinogen IX
Protoporphyrin IX
1q22
1.3.3.4
600923
variegate porphyria

Questions and formulas:
Question: what is the subtrate for enzyme ala dehydratase
Formula: UNIQUE(CHOOSECOLS(FILTER(A1:H1,A1="ALA dehydratase"),3))
Formula2: UNIQUE(CHOOSECOLS(FILTER(A2:H8,A2:A8="ALA dehydratase"),3))
Level: medium
Question: how many porphyria have substrate δ-aminolevulinic acid
Formula: ROWS(UNIQUE(FILTER(H1, C1="δ-Aminolevulinic acid")))
Formula2: ROWS(UNIQUE(FILTER(H2:H8, C2:C8="δ-Aminolevulinic acid")))
Level: medium
Question: give the location of subtrate coproporphyrinogen iii
Formula: UNIQUE(CHOOSECOLS(FILTER(A1:H1,C1="Coproporphyrinogen III"),2))
Formula2: UNIQUE(CHOOSECOLS(FILTER(A2:H8,C2:C8="Coproporphyrinogen III"),2))
Level: medium