Question: What is this disease related to abnormality in the oxygen-carrying protein haemoglobin that Chukwuedu Nwokolo is carrying out research on?

<P0-S0> Folding@home (FAH or F@h) is a distributed computing project for disease research that simulates protein folding, computational drug design, and other types of molecular dynamics. <P0-S1>  The project uses the idle processing resources of thousands of personal computers owned by volunteers who have installed the software on their systems. <P0-S2>  Its main purpose is to determine the mechanisms of protein folding, which is the process by which proteins reach their final three-dimensional structure, and to examine the causes of protein misfolding. <P0-S3>  This is of significant academic interest with major implications for medical research into Alzheimer's disease, Huntington's disease, and many forms of cancer, among other diseases. <P0-S4>  To a lesser extent, Folding@home also tries to predict a protein's final structure and determine how other molecules may interact with it, which has applications in drug design. <P0-S5>  Folding@home is developed and operated by the Pande Laboratory at Stanford University, under the direction of Prof. Vijay Pande, and is shared by various scientific institutions and research laboratories across the world. <SEP> <P1-S0> Sickle-cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. <P1-S1>  The most common type is known as sickle-cell anaemia (SCA). <P1-S2>  It results in an abnormality in the oxygen-carrying protein haemoglobin (hemoglobin S) found in red blood cells. <P1-S3>  This leads to a rigid, sickle-like shape under certain circumstances. <P1-S4>  Problems in sickle cell disease typically begin around 5 to 6 months of age. <P1-S5>  A number of health problems may develop, such as attacks of pain ("sickle-cell crisis"), anemia, swelling in the hands and feet, bacterial infections, and stroke. <P1-S6>  Long term pain may develop as people get older. <P1-S7>  The average life expectancy in the developed world is 40 to 60 years. <SEP> <P2-S0> Chukwuedu Nathaniel II Nwokolo (19 April 1921 – 18 May 2014) was an internationally distinguished tropical diseases, nutrition, human, medical, biological and life sciences expert; plus research scientist, scholar, pioneer medical doctor, author, humanitarian and acclaimed professor of medicine. <P2-S1>  He was Nigerian, and is listed in the "Who's Who in Nigeria" series by Newswatch. <P2-S2>  Nwokolo was outstandingly recognised worldwide for discovering and mapping out the area of paragonimiasis lung disease in Eastern Nigeria, with a study of the disease in Africa and clinical research for its control. <P2-S3>  Nwokolo founded SICREP: Sickle Cell Research Programme to effectively fight the disease in Nigeria and globally. <SEP> <P3-S0> Beta globin (also referred to as HBB, β-globin, haemoglobin beta, hemoglobin beta, or preferably haemoglobin subunit beta) is a globin protein, which along with alpha globin (HBA), makes up the most common form of haemoglobin in adult humans, the HbA. <P3-S1>  It is 146 amino acids long and has a molecular weight of 15,867 Da. <P3-S2>  Normal adult human HbA is a heterotetramer consisting of two alpha chains and two beta chains.