Question: What acute metabolic condition can be defined by the elevation of a yellow compound that occurs in normal catabolic pathway that breaks down heme in vertebrates? 

<P0-S0> Metabolomic Pathway Analysis, shortened to MetPA, is a freely available, user-friendly web server to assist with the identification analysis and visualization of metabolic pathways using metabolomic data. <P0-S1>  MetPA makes use of advances originally developed for pathway analysis in microarray experiments and applies those principles and concepts to the analysis of metabolic pathways. <P0-S2>  For input, MetPA expects either a list of compound names (identified as statistically significant or significant perturbed) or a metabolite concentration table with phenotypic labels (i.e. sick vs. healthy). <P0-S3>  The list of compounds can include common names, HMDB IDs or KEGG IDs with one compound per row. <P0-S4>  Compound concentration tables must have samples in rows and compounds in columns. <P0-S5>  MetPA’s output is a series of tables indicating which pathways are significantly enriched (along with accompanying statistics) as well as a variety of graphs or pathway maps illustrating where and how certain pathways were enriched. <P0-S6>  MetPA’s graphical output uses a colorful Google-Maps visualization system that allows simple, intuitive data exploration that lets users employ a computer mouse or track pad to select, drag and place images and to seamlessly zoom in and out. <P0-S7>  Users can explore MetPA’s output using three different views or levels: 1) a metabolome view; 2) a pathway view; 3) a compound view. <SEP> <P1-S0> Bilirubin (formerly referred to as haematoidin and discovered by Rudolf Virchow in 1847) is a yellow compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates. <P1-S1>  This catabolism is a necessary process in the body's clearance of waste products that arise from the destruction of aged red blood cells. First the hemoglobin gets stripped of the heme molecule which thereafter passes through various processes of porphyrin catabolism, depending on the part of the body in which the breakdown occurs. <P1-S2>  For example, the molecules excreted in the urine differ from those in the faeces. <P1-S3>  The production of biliverdin from heme is the first major step in the catabolic pathway, after which the enzyme biliverdin reductase performs the second step, producing bilirubin from biliverdin. <SEP> <P2-S0> Zieve's syndrome is an acute metabolic condition that can occur during withdrawal from prolonged alcohol abuse. <P2-S1>  It is defined by hemolytic anemia (with spur cells and acanthocytes), hyperlipoproteinaemia (excessive blood lipoprotein), jaundice (elevation of unconjugated bilirubin), and abdominal pain. <P2-S2>  The underlying cause is liver delipidization. <P2-S3>  This is distinct from alcoholic hepatitis which, however, may present simultaneously or develop later. <SEP> <P3-S0> The RecF pathway, also called the RecFOR pathway, is a pathway of homologous recombination that repairs DNA in bacteria. <P3-S1>  It repairs breaks that occur on only one of DNA's two strands, known as single-strand gaps. <P3-S2>  The RecF pathway can also repair double-strand breaks in DNA when the RecBCD pathway, another pathway of homologous recombination in bacteria, is inactivated by mutations. <P3-S3>  Like the RecBCD pathway, the RecF pathway requires RecA for strand invasion. <P3-S4>  The two pathways are also similar in their phases of branch migration, in which the Holliday junction slides in one direction, and resolution, in which the Holliday junctions are cleaved apart by enzymes.