Question: Between two Americans, Mameve Medwed and Sherman Alexie, who works in a broader range of arts?

<P0-S0> Epoxygenases are a set of membrane-bound, heme-containing cytochrome P450 (CYP P450 or just CYP) enzymes that metabolize polyunsaturated fatty acids to epoxide products that have a range of biological activities. <P0-S1>  The most thoroughly studied substrate of the CYP epoxylgenases is arachidonic acid. <P0-S2>  This polyunsaturated fatty acid is metabolized by cyclooxygenases to various prostaglandin, thromboxane, and prostacyclin metabolites in what has been termed the first pathway of eicosanoid production; it is also metabolized by various lipoxygenases to hydroxyeicosatetraenoic acids (e.g. 5-Hydroxyeicosatetraenoic acid, 12-Hydroxyeicosatetraenoic acid, 15-hydroxyicosatetraenoic acid) and leukotrienes (e.g. leukotriene B4, leukotriene C4) in what has been termed the second pathway of eicosanoid production. <P0-S3>  The metabolism of arachidonic acid to epoxyeicosatrienoic acids by the CYP epoxygenases has been termed the third pathway of eicosanoid metabolism. <P0-S4>  Like the first two pathways of eicosanoid production, this third pathway acts as a signaling pathway wherein a set of enzymes (the epoxygenases) metabolize arachidonic acid to a set of products (the eicosatrienoic acid epoxides, abbreviated as EETs, which are classified as nonclassic eicosanoids) that act as secondary signals to work in activating their parent or nearby cells and thereby orchestrate functional responses. <P0-S5>  However, none of these three pathways is limited to metabolizing arachidonic acid to eicosanoids. <P0-S6>  Rather, they also metabolize other polyunsaturated fatty acids to products that are structurally analogous to the eicosanoids but often have different bioactivity profiles. <P0-S7>  This is particularly true for the CYP epoxygenases which in general act on a broader range of polyunsaturated fatty acids to form a broader range of metabolites than the first and second pathways of eicosanoid production. <P0-S8>  Furthermore, the latter pathways form metabolites many of which act on cells by binding with and thereby activating specific and well-characterized receptor proteins; no such receptors have been fully characterized for the epoxide metabolites. <P0-S9>  Finally, there are relatively few metabolite-forming lipoxygenases and cyclooxygenases in the first and second pathways and these oxygenase enzymes share similarity between humans and other mammalian animal models. <P0-S10>  The third pathway consists of a large number of metabolite-forming CYP epoxygenases and the human epoxygenases have important differences from those of animal models. <P0-S11>  Partly because of these differences, it has been difficult to define clear roles for the epoxygenase-epoxide pathways in human physiology and pathology. <SEP> <P1-S0> Sherman Joseph Alexie, Jr. (born October 7, 1966) is a Spokane-Coeur d'Alene-American novelist, short story writer, poet, and filmmaker. <P1-S1>  Much of his writing draws on his experiences as an Indigenous American with ancestry from several tribes. <P1-S2>  He grew up on the Spokane Indian Reservation and now lives in Seattle, Washington. <SEP> <P2-S0> Reservation Blues is a 1995 novel by American writer Sherman Alexie (Spokane-Coeur d'Alene). <P2-S1>  The novel follows the story of the rise and fall of a rock and blues band of Spokane Indians from the Spokane Reservation. <P2-S2>  In 1995, Thomas Builds-The-Fire, Junior Polatkin, and Victor Joseph, who also appear in Sherman Alexie's short story collection "The Lone Ranger and Tonto Fistfight in Heaven," meet American blues musician Robert Johnson. <P2-S3>  He sold his soul to the devil in 1931 and claims to have faked his death seven years later. <P2-S4>  The three boys start a rock and blues band in Spokane using Johnson's enchanted guitar. <SEP> <P3-S0> Mameve Medwed is an American novelist. <P3-S1>  Born and raised in Bangor, Maine, she received her B.A. with honors from Simmons College and now lives in Cambridge, Massachusetts. <P3-S2>  She is the author of "Mail", "Host Family", "The End of an Error", "How Elizabeth Barrett Browning Saved My Life" (for which she received a 2007 Massachusetts Book Awards Fiction Honor), and "Of Men and Their Mothers".