Question: Where are the headquarters of the company that developed Crizanlizumab?

<P0-S0> Crizanlizumab is a monoclonal antibody developed by Novartis targeted towards P-selectin. <P0-S1>  It was announced by the company as an effective drug to prevent vaso-occlusive crisis in patients with Sickle cell anemia. <P0-S2>  The result of the Phase II SUSTAIN clinical trial was published on December 3, 2016 which showed the efficacy of the drug in sickle cell patients. <P0-S3>  Trial was conducted among 196 patients over 12 months which showed reduction in annual rate of sickle cell crises by 45% compared to the placebo group. <SEP> <P1-S0> Novartis International AG is a Swiss multinational pharmaceutical company based in Basel, Switzerland. <P1-S1>  It is one of the largest pharmaceutical companies by both market cap and sales. <SEP> <P2-S0> Commerce Square is a Class-A, high-rise office building complex in Center City Philadelphia, Pennsylvania, United States. <P2-S1>  Commerce Square consists of One and Two Commerce Square, two identical 41-story office towers 565 ft high that surround a paved courtyard of 30000 sqft . <P2-S2>  Architecturally, the granite-clad towers feature setbacks on the north and south sides of the building and are topped with a pair of stone diamonds with cutout squares in the center. <P2-S3>  The towers were built as part an office-building boom Philadelphia was experiencing on West Market Street in the late 1980s. <P2-S4>  Designed by IM Pei & Partners (now called Pei Cobb Freed & Partners), the towers were developed in a joint venture between Maguire Thomas Partners and IBM. <P2-S5>  IBM also leased more than half of One Commerce Square for the company's Mid-Atlantic headquarters. <P2-S6>  Construction of the first phase, which included One Commerce Square, the plaza, and retail space, began in 1985 and was completed in 1987. <P2-S7>  The project's second phase, Two Commerce Square, did not begin until a lead tenant was secured for the building in 1990. <P2-S8>  Consolidated Rail Corporation (Conrail) agreed to be Two Commerce Square's lead tenant and make the skyscraper its corporate headquarters after a two-year search for office space in the region. <P2-S9>  Two Commerce Square ended the skyscraper construction boom of the 1980s when it was completed in 1992. <P2-S10>  No other office skyscraper was built in Philadelphia until Brandywine Realty Trust (NYSE: BDN) built the Cira Centre in 2005. <SEP> <P3-S0> migme Limited (formerly mig33) is a global digital media company focused on emerging markets. <P3-S1>  The company is registered in Australia and listed on the Australian Securities Exchange (ASX:MIG) on 11 August 2014. <P3-S2>  There is also a secondary listing on the Deutsche Borse (WKN: A117AB). <P3-S3>  The company was formed in Perth, Australia in 2006 and commenced operations under the name mig33. <P3-S4>  In 2014, it was rebranded migme (and underwent a product and corporate overhaul). <P3-S5>  FIH Mobile, a handset unit of Taiwanese consumer electronics group Hon Hai Precision, took a 19.9% stake in the company in 2014. <P3-S6>  Originally developed as a social chatting and gaming application for feature phones, migme has grown to become a mobile entertainment platform that services Southeast Asia, South Asia, the Middle East and Africa. <P3-S7>  The company headquarters are in Singapore with offices in Malaysia, Indonesia, Taiwan, Hong Kong and Australia. <P3-S8>  The company delivers social entertainment services through portfolio brands migme, LoveByte, alivenotdead and Sold.