Question: MacAdam/Cage published what novel that has been classified as both science fiction and romance, and examines issues of love, loss, and free will?

<P0-S0> Foundation: The International Review of Science Fiction is a critical peer-reviewed literary magazine established in 1972 that publishes articles and reviews about science fiction. <P0-S1>  It is published triannually (spring, summer, and winter) by the Science Fiction Foundation. <P0-S2>  "Worlds Without End" called it "the essential critical review of science fiction", whilst "The Encyclopedia of Science Fiction" has called it "perhaps the liveliest and indeed the most critical of the big three critical journals" (the others being Extrapolation (journal) and Science Fiction Studies). <P0-S3>  A long-running feature was the series of interviews and autobiographical pieces with leading writers, entitled "The Profession of Science Fiction", a selection of which was edited and published by Macmillan Publishers in 1992. <P0-S4>  Several issues have been themed, including #93 ("A Celebration of British Science Fiction", 2005), published also as part of the Foundation Studies in Science Fiction. <P0-S5>  The hundredth edition (Summer 2007) was unusual in that it was an all-fiction issue, including stories by such writers as Vandana Singh, Tricia Sullivan, Karen Traviss, Jon Courtenay Grimwood, John Kessel, Nalo Hopkinson, Greg Egan, and Una McCormack. <P0-S6>  Back issues of the journal are archived at the University of Liverpool's SF Hub whilst more recent issues can be found electronically via the database providers ProQuest. <SEP> <P1-S0> Columbia Publications was an American publisher of pulp magazines featuring the genres of science fiction, westerns, detective stories, romance, and sports fiction. <P1-S1>  The company published such writers as Isaac Asimov, Louis L'Amour, Arthur C. Clarke, Randall Garrett, Edward D. Hoch, and William Tenn. <P1-S2>  Operating from the mid-1930s to 1960, Columbia's most notable magazines were the science fiction pulps "Future Science Fiction", "Science Fiction", and "Science Fiction Quarterly". <P1-S3>  Other long-running titles included "Double Action Western Magazine" (1934–1960), "Real Western" (1935–1960), "Western Action" (1936–1960), "Famous Western" (1937–1960), "Today's Love Stories" (1938–1959), and "Super Sports" (1939–1957). <P1-S4>  In addition to pulp magazines, the company also published some paperback novels, primarily in the science fiction genre. <SEP> <P2-S0> MacAdam/Cage is a small publishing firm located in San Francisco, California. <P2-S1>  It was founded by publisher David Poindexter in 1998. <P2-S2>  As of 2003, it published around 30 to 45 titles per year, primarily fiction, short story collections, history, biography, and essays, and had twelve employees. <P2-S3>  Most notably, it published "The Time Traveler's Wife" by Audrey Niffenegger and "The Contortionist's Handbook" by Craig Clevenger. " <P2-S4> Publishers Weekly" describes MacAdam/Cage as "one of the West Coast's most literary" independent publishing firms. <SEP> <P3-S0> The Time Traveler's Wife is the debut novel of American author Audrey Niffenegger, published in 2003. <P3-S1>  It is a love story about a man with a genetic disorder that causes him to time travel unpredictably, and about his wife, an artist, who has to cope with his frequent absences and dangerous experiences. <P3-S2>  Niffenegger, frustrated in love when she began the work, wrote the story as a metaphor for her failed relationships. <P3-S3>  The tale's central relationship came to her suddenly and subsequently supplied the novel's title. <P3-S4>  The novel, which has been classified as both science fiction and romance, examines issues of love, loss, and free will. <P3-S5>  In particular, it uses time travel to explore miscommunication and distance in relationships, while also investigating deeper existential questions.