Question: Where are the headquarters of the company that developed Crizanlizumab?

Novartis International AG is a Swiss multinational pharmaceutical company based in Basel, Switzerland.  It is one of the largest pharmaceutical companies by both market cap and sales. <SEP> Commerce Square is a Class-A, high-rise office building complex in Center City Philadelphia, Pennsylvania, United States.  Commerce Square consists of One and Two Commerce Square, two identical 41-story office towers 565 ft high that surround a paved courtyard of 30000 sqft .  Architecturally, the granite-clad towers feature setbacks on the north and south sides of the building and are topped with a pair of stone diamonds with cutout squares in the center.  The towers were built as part an office-building boom Philadelphia was experiencing on West Market Street in the late 1980s.  Designed by IM Pei & Partners (now called Pei Cobb Freed & Partners), the towers were developed in a joint venture between Maguire Thomas Partners and IBM.  IBM also leased more than half of One Commerce Square for the company's Mid-Atlantic headquarters.  Construction of the first phase, which included One Commerce Square, the plaza, and retail space, began in 1985 and was completed in 1987.  The project's second phase, Two Commerce Square, did not begin until a lead tenant was secured for the building in 1990.  Consolidated Rail Corporation (Conrail) agreed to be Two Commerce Square's lead tenant and make the skyscraper its corporate headquarters after a two-year search for office space in the region.  Two Commerce Square ended the skyscraper construction boom of the 1980s when it was completed in 1992.  No other office skyscraper was built in Philadelphia until Brandywine Realty Trust (NYSE: BDN) built the Cira Centre in 2005. <SEP> migme Limited (formerly mig33) is a global digital media company focused on emerging markets.  The company is registered in Australia and listed on the Australian Securities Exchange (ASX:MIG) on 11 August 2014.  There is also a secondary listing on the Deutsche Borse (WKN: A117AB).  The company was formed in Perth, Australia in 2006 and commenced operations under the name mig33.  In 2014, it was rebranded migme (and underwent a product and corporate overhaul).  FIH Mobile, a handset unit of Taiwanese consumer electronics group Hon Hai Precision, took a 19.9% stake in the company in 2014.  Originally developed as a social chatting and gaming application for feature phones, migme has grown to become a mobile entertainment platform that services Southeast Asia, South Asia, the Middle East and Africa.  The company headquarters are in Singapore with offices in Malaysia, Indonesia, Taiwan, Hong Kong and Australia.  The company delivers social entertainment services through portfolio brands migme, LoveByte, alivenotdead and Sold. <SEP>  It was announced by the company as an effective drug to prevent vaso-occlusive crisis in patients with Sickle cell anemia. Crizanlizumab is a monoclonal antibody developed by Novartis targeted towards P-selectin.  The result of the Phase II SUSTAIN clinical trial was published on December 3, 2016 which showed the efficacy of the drug in sickle cell patients.  Trial was conducted among 196 patients over 12 months which showed reduction in annual rate of sickle cell crises by 45% compared to the placebo group.