Question: The Tyne–Tees derby is a term which is often applied to football matches between Middlesbrough and a town that was founded in what year?

 The two towns are separated by just 34 miles, in a region where there are only 3 major professional football clubs.  It can also include a match between Newcastle United and Hartlepool United. The Tyne–Tees derby is a term which is often applied to football matches between Newcastle United and Middlesbrough. <SEP>  Newcastle United was founded in 1892 by the merger of Newcastle East End and Newcastle West End, and has played at its current home ground, St James' Park, ever since.  The ground was developed into an all-seater stadium in the mid-1990s and now has a capacity of 52,354. Newcastle United Football Club is an English professional association football club based in Newcastle upon Tyne, that currently plays in the Premier League, the top tier of English football. <SEP> The Tyne-Wear derby, also known as the North East derby and the Wear-Tyne derby is a local derby between the association football clubs Sunderland and Newcastle United.  The derby is an inter-city rivalry in North East England with the two cities of Sunderland and Newcastle just twelve miles apart.  Sunderland play their home matches at the Stadium of Light whilst Newcastle play their home matches at St. James' Park.  The first meeting of the two sides took place in 1883, with the first competitive fixture being an 1888 FA Cup tie, which Sunderland won 2–1.  To date, both teams have won the fixture 53 times, whilst sharing 49 draws – one of which Sunderland went on to win via a penalty shootout.  Sunderland have dominated the Tyne–Wear derby in recent seasons.  They are currently undefeated in the last nine matches between the local rivals, including six consecutive victories from 14 April 2013 to 25 October 2015.  The most recent meeting of the two sides, on the 20th March 2016, was a Premier League match at the St James' Park and ended in a 1–1 draw, with Jermain Defoe opening the scoring for Sunderland before Aleksandar Mitrovic equalised for Newcastle.  Yann M'Vila, who has played in both games, describes it as bigger than the Milan derby. <SEP> The term macromolecular assembly (MA) refers to massive chemical structures such as viruses and non-biologic nanoparticles, cellular organelles and membranes and ribosomes, etc. that are complex mixtures of polypeptide, polynucleotide, polysaccharide or other polymeric macromolecules.  They are generally of more than one of these types, and the mixtures are defined spatially (i.e., with regard to their chemical shape), and with regard to their underlying chemical composition and structure.  Macromolecules are found in living and nonliving things, and are composed of many hundreds or thousands of atoms held together by covalent bonds; they are often characterized by repeating units (i.e., they are polymers).  Assemblies of these can likewise be biologic or non-biologic, though the MA term is more commonly applied in biology, and the term supramolecular assembly is more often applied in non-biologic contexts (e.g., in supramolecular chemistry and nanotechnology).  MAs of macromolecules are held in their defined forms by non-covalent intermolecular interactions (rather than covalent bonds), and can be in either non-repeating structures (e.g., as in the ribosome (image) and cell membrane architectures), or in repeating linear, circular, spiral, or other patterns (e.g., as in actin filaments and the flagellar motor, image).  The process by which MAs are formed has been termed molecular self-assembly, a term especially applied in non-biologic contexts.  A wide variety of physical/biophysical, chemical/biochemical, and computational methods exist for the study of MA; given the scale (molecular dimensions) of MAs, efforts to elaborate their composition and structure and discern mechanisms underlying their functions are at the forefront of modern structure science.