Question: Which publication covers a broader range of topics, Cigar Aficionado or Our State?

Drew Nieporent is a New York City restaurateur.  His company Myriad Restaurant Group owns and operates numerous restaurants, many of which are known for their celebrity clientele, and in some cases celebrity co-owners.  Many are known for their difficulty in obtaining reservations.  In an interview with "Cigar Aficionado", Nieporent recalled turning down Henry Kissinger. <SEP>  First published in 1933 as "The State" magazine, the publication has become "the oldest regional publication of its kind in the country," according to the Associated Press.  It is a member of the City and Regional Magazine Association (CRMA). Our State (full title: Our State: Down Home in North Carolina) is a monthly magazine based in Greensboro, North Carolina, featuring travel and history articles and photographs about North Carolina people, places and events. <SEP> Epoxygenases are a set of membrane-bound, heme-containing cytochrome P450 (CYP P450 or just CYP) enzymes that metabolize polyunsaturated fatty acids to epoxide products that have a range of biological activities.  The most thoroughly studied substrate of the CYP epoxylgenases is arachidonic acid.  This polyunsaturated fatty acid is metabolized by cyclooxygenases to various prostaglandin, thromboxane, and prostacyclin metabolites in what has been termed the first pathway of eicosanoid production; it is also metabolized by various lipoxygenases to hydroxyeicosatetraenoic acids (e.g. 5-Hydroxyeicosatetraenoic acid, 12-Hydroxyeicosatetraenoic acid, 15-hydroxyicosatetraenoic acid) and leukotrienes (e.g. leukotriene B4, leukotriene C4) in what has been termed the second pathway of eicosanoid production.  The metabolism of arachidonic acid to epoxyeicosatrienoic acids by the CYP epoxygenases has been termed the third pathway of eicosanoid metabolism.  Like the first two pathways of eicosanoid production, this third pathway acts as a signaling pathway wherein a set of enzymes (the epoxygenases) metabolize arachidonic acid to a set of products (the eicosatrienoic acid epoxides, abbreviated as EETs, which are classified as nonclassic eicosanoids) that act as secondary signals to work in activating their parent or nearby cells and thereby orchestrate functional responses.  However, none of these three pathways is limited to metabolizing arachidonic acid to eicosanoids.  Rather, they also metabolize other polyunsaturated fatty acids to products that are structurally analogous to the eicosanoids but often have different bioactivity profiles.  This is particularly true for the CYP epoxygenases which in general act on a broader range of polyunsaturated fatty acids to form a broader range of metabolites than the first and second pathways of eicosanoid production.  Furthermore, the latter pathways form metabolites many of which act on cells by binding with and thereby activating specific and well-characterized receptor proteins; no such receptors have been fully characterized for the epoxide metabolites.  Finally, there are relatively few metabolite-forming lipoxygenases and cyclooxygenases in the first and second pathways and these oxygenase enzymes share similarity between humans and other mammalian animal models.  The third pathway consists of a large number of metabolite-forming CYP epoxygenases and the human epoxygenases have important differences from those of animal models.  Partly because of these differences, it has been difficult to define clear roles for the epoxygenase-epoxide pathways in human physiology and pathology. <SEP>  Published since September 1992, the magazine is known for its articles about different brands of cigars worldwide, and for the celebrities that have appeared on its cover. Cigar Aficionado is an American magazine that is dedicated to the world of cigars.  It is also noted for its opposition to the Cuban embargo.  The magazine was launched by Marvin R. Shanken's M. Shanken Communications, the publisher of "Wine Spectator" magazine since 1976.  The current editor is David Savona.