Question: Which catastrophic event in 1876, in Brooklyn, resulted in the death of 278 individuals and which destroyed the former Park Theatre, leased to Sarah Crocker Conway at that time but who continued in the lease on the new building in which her husband played leading parts?

<P0-S0> Chromothripsis is the phenomenon by which up to thousands of clustered chromosomal rearrangements occur in a single event in localised and confined genomic regions in one or a few chromosomes, and is known to be involved in both cancer and congenital diseases. <P0-S1>  It occurs through one massive genomic rearrangement during a single catastrophic event in the cell's history. <P0-S2>  It is believed that for the cell to be able to withstand such a destructive event, the occurrence of such an event must be the upper limit of what a cell can tolerate and survive. <P0-S3>  The chromothripsis phenomenon opposes the conventional theory that cancer is the gradual acquisition of genomic rearrangements and somatic mutations over time. <SEP> <P1-S0> The Brooklyn Theatre Fire was a catastrophic theatre fire that broke out on the evening of December 5, 1876, in the then-city of Brooklyn (now a borough of New York City). <P1-S1>  The conflagration killed at least 278 individuals, with some accounts reporting more than 300 dead. <P1-S2>  One hundred and three unidentified victims were interred in a common grave at Green-Wood Cemetery. <P1-S3>  An obelisk near the main entrance at Fifth Avenue and 25th Street marks the burial site. <P1-S4>  More than two dozen identified victims were interred individually in separate sections at the Cemetery of the Evergreens in Brooklyn. <SEP> <P2-S0> After a successful career as a Queensland and then Australian international representative, in the 1954 pre-season Crocker signed a then record one-season deal for an Australian to move south and play for Sydney club Parramatta in order to assist his family who had lost their home in a fire the previous year. <P2-S1>  Parramatta finished the 1954 NSWRFL season with the wooden spoon however. <P2-S2>  In the post season Crocker was selected for the Australian national team's campaign for the 1954 Rugby League World Cup tournament, the first ever, which was held in France. <P2-S3>  Crocker didn't play in the Kangaroos' first match which was lost to Great Britain, but was selected as a second-row forward for the second match against New Zealand which Australia won. <P2-S4>  He played in the third match against France which the Australians lost, meaning they would fail to reach the final. <P2-S5>  He is listed on the Australian Players Register as Kangaroo No. 278. <P2-S6>  The following season was Crocker's last in the NSWRFL Premiership's first grade. <SEP> <P3-S0>  She was a sister of Elizabeth Crocker Bowers, also an actress. <P3-S1>  She made her debut in Baltimore, Maryland in 1849, playing Parthenia and other leading parts. <P3-S2>  In May 1852, she married the actor Frederick B. Conway, and the two thenceforward acted together. <P3-S3> Sarah Crocker Conway (b. Ridgefield, Connecticut, 1834; d. Brooklyn, New York, April 28, 1875) was an actress. <P3-S4>  In 1859, they opened Pike's Opera House in Cincinnati, Ohio with a first-class company, but the engagement was not profitable, and they returned to the east. <P3-S5>  In 1861, they visited England, and filled a short engagement at Sadler's Wells Theatre, London. <P3-S6>  After their return, they became star actors, and made an extensive and profitable tour. <P3-S7>  In 1864 Sarah leased the Park Theatre in Brooklyn, and subsequently the new Brooklyn Theatre, in which for nine years her husband played leading parts. <P3-S8>  Sarah Conway possessed a tall and graceful figure and an expressive countenance, and was a versatile actress and a popular theatre manager.