Question: John Crowley, who is an American biotechnology executive and entrepreneur, and his wife Aileen are the real life inspiration for the movie "Extraordinary Measures" after creating a biotechnology company to save the lives of their children who have what life-threatening disease?

<P0-S0> Henri A. Termeer (28 February 1946 – 12 May 2017) was a Dutch biotechnology executive and entrepreneur who is considered a pioneer in corporate strategy in the biotechnology industry for his tenure as CEO at Genzyme. <P0-S1>  Termeer created a business model adopted by many others in the biotech industry by garnering steep prices— mainly from insurers and government payers— for therapies for rare genetic disorders known as orphan diseases that mainly affect children. <P0-S2>  Genzyme uses biological processes to manufacture drugs that are not easily copied by generic-drug makers. <P0-S3>  The drugs are also protected by orphan drug acts in various countries which provides extensive protection from competition and ensures coverage by publicly funded insurers. <P0-S4>  As CEO of Genzyme from 1981 to 2011, he developed corporate strategies for growth including optimizing institutional embeddedness nurturing vast networks of influential groups and clusters: doctors, private equity, patient-groups, insurance, healthcare umbrella organizations, state and local government, alumni. <P0-S5>  Termeer is "connected to 311 board members in 17 different organizations across 20 different industries" including Verastem, Inc. <P0-S6>  He has the legacy of being the "longest-serving CEO in the biotechnology industry. <SEP> <P1-S0>  He co-founded Novazyme Pharmaceuticals with William Canfield, which was later acquired by Genzyme Corporation, and founded Orexigen Therapeutics. <P1-S1>  In 2006, he was profiled in the book "The Cure: How a Father Raised $100 Million – And Bucked the Medical Establishment – In a Quest to Save His Children" by Geeta Anand. <P1-S2> John Francis Crowley (born April 7, 1967) is an American biotechnology executive and entrepreneur and the chairman and CEO of Amicus Therapeutics. <P1-S3>  In 2010, Crowley released his memoir, "Chasing Miracles: The Crowley Family Journey of Strength, Hope, and Joy." <P1-S4>  Crowley and his family were the inspiration for the movie "Extraordinary Measures" starring Harrison Ford in 2010. <SEP> <P2-S0> Extraordinary Measures is a 2010 American medical drama film starring Brendan Fraser, Harrison Ford, and Keri Russell. <P2-S1>  It was the first film produced by CBS Films, the film division of CBS Corporation, who released the film on January 22, 2010. <P2-S2>  The film is based on the true story of John and Aileen Crowley, whose children have Pompe's disease. <P2-S3>  The film was shot in St. Paul, Oregon; Portland, Oregon; the Corner Saloon in Tualatin, Oregon; Manzanita, Oregon; Beaverton, Oregon, and Vancouver, Washington. <P2-S4>  The film is about parents who form a biotechnology company to develop a drug to save the lives of their children, who have a life-threatening disease. <SEP> <P3-S0> William Canfield is a glycobiologist, chief scientific officer and founder of an Oklahoma City-based biotechnology company, Novazyme, which was acquired by Genzyme in August 2001 and developed, among other things, an enzyme that can stabilize (but not cure) Pompe disease, based on Canfield's ongoing research since 1998. <P3-S1>  Canfield subsequently left Genzyme and established, with his partner in the Novazyme operation, John Crowley, another research laboratory (Cytovance Biologics), which he still heads. <P3-S2>  He saved Cytovance from bankruptcy by forming an investor group and raising $9 million after Crowley suddenly left the lab in 2005 to become the chief executive officer at Amicus Therapeutics in New Jersey