Original: Pre-Columbian is used especially often in the context of the great indigenous civilizations of the Americas, such as those of Mesoamerica (the Aztec and Maya) and of the Andes (Inca, Moche and Chibcha).
Simplified: Pre-Columbian can also mean cultures of any one of the great native civilizations of the Americas, such as those of Mesoamerica (the Aztec and Maya) and of the Andes (Inca, Moche and Chibcha).