Original: In contrast to many other amphitheatres, which were located on the outskirts of a city, the Colosseum was constructed in the city center; in effect, placing it both literally and symbolically at the heart of Rome.
Simplified: Usually in Roman cities, the amphitheatres were built on the edge of the city. The Colosseum was built in the city center; in effect, placing it in the real and symbolic heart of Rome.