Input (grade 11): Following maturation, the lymphocytes enter the circulation and peripheral lymphoid organs (e.g. the spleen and lymph nodes) where they survey for invading pathogens and\/or tumor cells.
Output (grade 8): After they mature, the lymphocytes enter the circulation and lymphoid organs (e.g. the spleen and lymph nodes) where they are able to sense invading pathogens and tumor cells.