The struggle for power between the Papacy and the Holy Roman Empire had arisen with the Investiture Conflict which began in 1075 and ended with the Concordat of Worms in 1122 , but the division between Guelphs and Ghibellines in Italy persisted to the 15th century .
The struggle for power between the Papacy and the Holy Roman Empire had arisen with the Investiture Conflict which began in 1075 and ended with the Concordat of Worms in 1122 . 
 However the division between Guelphs and Ghibellines in Italy persisted to the 15th century .