Cold - patches have been used to induce analgesia or relief in pain as result of traumatic injuries ; its mechanism remained obscure till the discovery of TRPM8 mediated cold analgesia in rats and mice lacking TRPM8 have seriously impaired cold - detection behavior .
Cold - patches have traditionally been used to induce analgesia or relief in pain which is caused as result of traumatic injuries . 
 It is now demonstrated using animal models that TRPM8 mediates cold analgesia in rats and mice lacking TRPM8 have seriously impaired cold - detection behavior .