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+Specific to the EB (elementary body) form in the life cycle of chlamydiae
+Expressed in the amnioserosa during germ band elongation, shortening and heart morphogenesis. Expressed in midgut throughout embryogenesis
+Expressed throughout the cell cycle independently of DNA synthesis. Levels increase from embryonic day 18 to postnatal day 10
+Expression of cwlD takes place in both the mother cell and forespore compartments of sporulating cells
+Expressed at high levels from the embryonic 2-cell stage through to the blastula stage, possibly due to inheritance of maternal transcripts. During later stages levels gradually decline
+Detected immediately after seed germination
+Detected in newborns. Levels increase during the first four weeks, and then remain at the same stable level
+Expressed during the early stages of nodule development in cells with growing infection threads upon symbiosis with Sinorhizobium meliloti
+Expressed in ovary between 16.5 dpc and P5
+Expression relatively broad during early stages of embryogenesis and more restricted to discrete groups of cells in mature embryos. Later, expression mainly restricted to the cotyledons and the apical meristem
+Expressed in the posterior silk glands throughout the penultimate and last larval instars. Declines in immobile pupae and disappears within the next 12 hours when insects pupate
+Expressed both maternally and zygotically. Zygotic expression continues throughout development
+Highly expressed during the cystic life stage
+Expressed in male L4 larvae and adults
+Highly expressed from the very early stages of embryogenesis to the globular stage, decreases rapidly from the late heart-torpedo stage and did not persist after the completion of embryogenesis
+The crystal protein is produced during sporulation and is accumulated both as an inclusion and as part of the spore coat
+Found in infective promastigote and in tissue amastigote stages
+Expressed in embryo and adult
+Expressed in fetal tissues, expression increases in lung and kidney adult tissues
+Expressed in immature GV-stage oocytes, mature MII-stage oocytes, parthenogenetically activated MII-stage oocytes and in pronuclear embryos (at protein level). During in vitro oocyte maturation, expression initially increases after 12 hours of culture, followed by a strong decline at 30 hours (MI stage) and 44 hours (MII stage). Expression remains constant in MII-stage oocytes after parthenogenetic activation, increasing in two- and four-cell parthenotes. Not detected in blastocyst stage embryos
+Detectable 2 hours after elicitation and disappears after 6 hours
+Expressed in larva (at protein level)
+Appears during early brain development where it increases with age to give high levels in the mature animal
+Accumulates progressively at very low levels during fruit development, and fades out in ripe fruit
+Expressed at the time of pollination and then immediately decreases to basal level
+Expression detected in the intestinal cells from 3-fold stage embryo to adult stages, and also in the hypodermis and in unidentified cells in the head from larval to adult stages
+Expressed during the first 6 hours of embryonic development, levels decline during larval and pupal stages to increase again during adulthood
+Most abundant in larval stage L3 (PubMed:7816808). Expressed in larval stages L3 and L4 (PubMed:18096150, PubMed:20506374). Weakly expressed in adult animals (PubMed:18096150)
+Found in newly hatched chick liver and decreases during postnatal development
+There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I
+Expressed in 0- to 2-hour-old embryos (at protein level) (PubMed:32165583). Expressed in the larval motor neuron cells in the brain (at protein level) (PubMed:29105522). Expressed throughout development in both the soma and germline. Widely expressed in early embryos with levels dropping during mid-embryogenesis and increasing again in late embryogenesis. Expression is relatively low during larval stages with lowest levels in the first and second instars and an increase during the third instar. Levels increase substantially during the pupal stage and remain relatively high in the adult. In the ovary, little expression in the germarium or previtellogenic stage chambers with levels increasing midway through oogenesis and remaining high until stage 10 (PubMed:21900268). In the testis, there is substantial up-regulation after mitosis is finished and the interconnected spermatocytes begin to grow (PubMed:23209437). Expression peaks as the mature spermatocytes go through meiosis and high levels are found in 32- and 64-cell spermatid cysts with expression persisting after the spermatids in the 64-cell cysts start differentiation and disappearing once elongation and nuclear condensation are completed (PubMed:23209437)
+Expressed in late sporogonial stages
+Expressed during the parasite blood stage, in schizonts (at protein level)
+In birds, the alpha-D chain occurs in a minor hemoglobin component, called hemoglobin d, which is expressed in late embryonic and adult life
+Expressed during development. Expression levels decrease steadily from the initiation of development until culmination. Levels increase after 18 hours of development and peak at 22 hours, after which they decrease again
+Basal levels of expression during all life stages, with higher levels during larval development peaking at larval instars 2/3
+Significant expression begins at postnatal day 15 and reaches a peak at postnatal day 22. Stable and high expression is detected after postnatal day 22
+It is present but some of the disulfide bonds are reduced in reticulate bodies (RBs)
+Expressed primarily during the first half of embryogenesis. Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells
+At low level in the third and fourth-stage larvae, and abundant in adult worms
+Rapid decrease in roots and leaves from the leaf opened to the green fruit stage
+Expressed at high levels during aggregation and late development and at low levels during the slug stage
+Oocytes, embryos, and adults
+Expression is constant during meiosis (at protein level)
+Weakly expressed in primary, post-settlement polyps and strongly in adult colonies. Not expressed in prawn stage, domut stage and presettlement planulae
+Primary spermatocytes
+Expression starts after birth in the central nervous system and parallels myelination process
+Most abundant in embryo. Gradually decreases during maturation
+During development, higher expression levels are detected in young rosette leaves, senescing leaves and petals and sepals at flower stage 15
+Expressed in gut mesenchyme during pre- and postnatal development. Expressed as well in the pharyngeal floor and pouches, and in the oral and branchial arch ectoderm. Expression persisted in the developing thyroid until birth, in mucous forming cells of salivary glands and in odontogenic epithelium of the mandible
+Postgastrulation-stage
+Expressed in embryos
+During male germ cell development, it was detected first in the 23-day-old mouse testis, and the signal increased with age
+Detected in the entire flower with strong signals in carpels, especially in differentiating ovules and the carpel wall. Patchy localization with strong levels in particular cells. In anthers, present at a high level in tetrads of microspores and the tapetum. After fertilization, mostly observed in the embryo up to the heart stage and in the chalazal endospem. Expressed at high levels in silique wall at all stages of carpel development
+In ripening fruit
+In the polyp and the medusa stages
+In embryos, expression is detected at 7 dpc, increases at 9.5 dpc, and then remains constant through 18.5 dpc (PubMed:19633199). Expression in the yolk sac is relatively constant between 10.5 dpc and 18.5 dpc (PubMed:19633199). Placenta expression is also constant throughout development with a slight decrease observed at 18.5 dpc (PubMed:19633199). Expressed in burst-forming unit-erythroid (BFU-E) progenitor cells and down-regulated as erythroid cells differentiate (PubMed:23748442)
+Secreted in the region between the embryo and inner layer of the eggshell. Expressed in excretory canal cells of embryos and at the 1.5-fold stage of embryonic development accumulates in the lumen of the excretory duct and pore. Expression ceases in the lumen of the excretory duct and pore prior to cuticle secretion. Thereafter expressed transiently in the lumen of the excretory duct and pore in the latter phase of each subsequent larval developmental stage. During the molt phase of larval development, accumulates in the space in between the new and old cuticles. During the L4 stage of larval development, accumulates in the vulval lumen
+Expressed in the outer segment of retinal photoreceptors at postnatal days 11 and 22
+Expressed from 4 to 20 days after pollination
+At 12 hours post-fertilization, the expression is restricted to Kupffer's vesicle
+Expressed during fruit ripening. Expression in mature tissues, such as ripe leaves and fruits, is considerably higher than in fast growing tissues, such as young leaves and fruits. In fruits, expression increases rapidly during storage at 25 degees Celsius, and is highest on day 12 after which it decreases dramatically
+At 14.5 dpc, expression is limited to the developing nervous system with strong expression in the developing cortex, midbrain, cerebellum and medulla. Weaker expression is also detected in the trigeminal ganglion
+May be up-regulated during progression from G1 to S phase of the cell cycle. Maximal expression in S or G2 phase
+Expressed at 14.5 dpc
+In oocytes, expressed during meiotic maturation (PubMed:22732570). Levels gradually decrease during oocyte maturation (at protein level) (PubMed:22732570)
+Expressed from day 3 of seedling development and continues throughout the development of photosynthetic tissues
+In 11.5 day embryos, highly and predominantly expressed in liver, with lower expression in somites, brain and craniofacial structures. Expression significantly decreases in 12.5 day embryos and in the newborn
+Early fruit ripening
+Expressed both maternally and zygotically. At 9 hpf, expressed in the dorsal epiblast and prospective tail regions, but absent from the ventral epiblast. At 10 hpf, expressed in presumptive diencephalon and hindbrain, in tissue lateral to the head, the posterior neural plate, tail bud and adjacent mesoderm. At 11-15 hpf, restricted expression along the A-P axis of the neural plate up to the rhobomere 1/2 boundary. During somitogenesis, head and tail expression remains. At 18 hpf, retained expression in the neural tube. At 24 hpf, low levels of ubiquitous expression with stronger expression in eyes, hindbrain and spinal cord; in hindbrain the anterior border is at rhombomeres 3-4. Also expressed in non-neural tissues including pharyngeal endoderm, mesenchyme and tail bud. At 48 hpf, expression is maintained in hindbrain, eyes, diencephalon and the pharyngeal region, and is also observed in forebrain, midbrain and pectoral fin bud
+During anther development, expressed from stage 6 to stage 9 in tapetal cells and developing microspores
+Haustoria and rust-infected leaves. Also observed, at lower levels, in spores or hyphae formed in vitro
+At 4 days post fertilization (dpf), it is expressed at low levels in the retina and brain, and at higher levels in the jaw mesenchyme
+Is first detectable at the neural plate stage (stage 14). Levels gradually increase during later neurula stages, and becomes fairly constant throughout tailbud and hatching stages before declining at late swimming tadpole stages
+Expression increases during erythroid development (at protein level) (PubMed:20800516). In pancreatic islets, expression increases during aging (PubMed:22611253)
+Accumulates at the earliest stages of sieve element differentiation (PubMed:17293437). In flowers, expressed in the vascular tissue of petals, sepals, stamens and in the gynoecium (PubMed:17293437)
+Differentially expressed during embryonic development, with highest expression in developing face, limbs, skeletal muscle, heart, and tail. Highly expressed in fetal thymocytes from day 14 to 16 of gestation, and expressed at much lower levels in adult thymus
+Expressed during germination et seedling growth
+First detected in 30-day old rats after which, levels increase during spermatid elongation. Levels decrease at the time of spermatid assembly and disappear just before spermiation
+Expressed in unfertilized eggs and in early embryos from 0 to 4 hours
+During ovary development, accumulates until the stage 3 and fades out progressively to disappear at stage 6
+In roots, expressed only in the quiescent center (QC), the columella stem cells (CC) and the innermost layer of central columella cells; mostly present in the second, third and fourth CC layers, at a lower level in undifferentiated CCs, but not, or only marginally, in the QC (PubMed:20798316, PubMed:23370719). Induced early during lateral root formation (PubMed:23370719)
+Highly expressed during early germination
+Highest levels in embryos and larvae. Expressed in vulval precursor cells at the time of vulval determination
+Isoform 1 is expressed in a cluster of cells in the anterior half at 2.5 hours post fertilization (hpf), in hypodermal cells at 5 hpf, in pharyngeal cells, intestinal and some neurons at 6 hpf. Isoform 1 is expressed in pharyngeal cells at L1 larval stage. Isoform 1 is expressed in somatic gonad precursor cells (SGPs) during the L2 larval stage. Isoform 2 is expressed in anterior neuronal cells and posterior hypodermal cells at 5 hpf, in neurons of the head at 7.6 hpf (at protein level). Expressed in somatic gonad founder cells Z1 and Z4, pharynx and muscles
+In roots, restricted to the vasculature and the tips of primary and secondary roots (PubMed:30309966). Also observed in the vascular bundles and tips of cotyledons, the base of true leaves, the ovarian stigma and pollen grains within the anthers, and the tip and base of the siliques (PubMed:30309966)
+Highly expressed during stationary phase
+Expressed early in development. Expressed from embryonic stem cells and throughout embryogenesis
+Levels are low in both the slow-twitch soleus and fast-twitch rectus femoris muscles at prenatal day 2, then increase slowly until postnatal day 3. At 2 weeks, levels in the rectus femoris muscle then decrease while those in the soleus muscle increase sharply, reaching adult levels by 4 weeks
+Expressed in zoospores. Not detected in non-sporulating hyphae, hyphae decorated with sporangia, ungerminated sporangia and directly germinating sporangia
+Highly expressed in the developing cerebral cortex and striatum at 14 dpc
+High expression in unfertilized eggs and from 0 to 4 hours in early embryos. Low expression in later developmental stages, with slight increase in 8-16 hour-old embryos and in adults
+Isoform 1 shows increasing levels of expression in the retina from birth, reaching maximal levels by 12 days of age
+Dramatically up-regulated upon neuronal differentiation
+Not expressed in dormant seeds. First detected 1 day after imbibition, reaching a maximum at 3 days after imbibition, then declining gradually
+Regulated during fruit maturation
+Expressed at high level as the tadpole tail resorbs and during hindlimb morphogenesis and intestinal remodeling
+Expressed both in adult and fetal tissues
+In the head region, first detected in 10-somite embryos in the stomodeum and rostral foregut. At day 3, expressed in Rathke pouch, in the mandibular and oral epithelia, in the foregut endoderm and in the posterior lateral plate mesoderm. Expression is maintained in these structures in later stages and at day 5, can be seen in the distal portion of the hindlimb
+Expressed at higher levels in some regions of the developing central and peripheral nervous system, including hippocampal neuroepithelium, rhinencephalon, intermediate thalamus
+Major secretory product synthesized by the bovine conceptus between days 15 and 25 of pregnancy
+Expressed in vegetative cells. Levels decrease dramatically as development begins, and remain low throughout the aggregation and loose mound stages. The levels become more abundant again at the tight-mound stage and remain high throughout the rest of development and fruiting body formation
+Expression gradually increases during embryonic stages and reaches a maximum in neonates
+A shorter isoform, which probably corresponds to isoform 2, is expressed both maternally and zygotically throughout early development. Isoform 1 is expressed only after the mid-blastula transition (MBT), becoming readily detectable after stage 14
+Highest levels in old segments of leaves, stems and roots
+Expressed at the last stage of senescence in old leaves
+Expressed both maternally and zygotically at all stages of development
+Present at late larval stages and adults
+Expression appears at the growth phase stage and rapidly increases after starvation began. It reaches its peak at 3 hours and is continually expressed for 12 hours after starvation has begun
+Present from tailbud stage (10 hpf) through to adult. Levels increase from 24-120 hpf
+Expressed at 7 dpc. At 11 dpc, expressed in the apical ectodermal ridge. At 13.5 dpc, expressed in the whisker pad, eyelid, breast primordia and developing limb. At 14.5 dpc, expressed in supraorbital and suborbital follicles, whisker pad, limbs and patches of developing epidermis
+Weakly expressed during late-oogenesis
+Expression depends on the cellular development of the chick liver
+Specifically expressed in the developing somites, concomitant with muscle differentiation
+Expressed at high levels in the late and post-exponential growth phases
+Expressed from embryos to adults (PubMed:28978740). First expressed at the twofold stage of embryonic elongation (PubMed:28978740). Localizes to distal tip cells of the gonad from the late L4 stage to adulthood (PubMed:28978740)
+Expressed in late stage embryos. Disappears by early larval states and reappears in the third larval instar. Subsequently maintained throughout pupal development until adulthood
+Expressed in the lacrimal duct at embryonic day (E)19 and in both the lacrimal duct and lacrimal gland at post natal day (P)30
+Highly expressed in young fruit with reduced expression in the later stages of fruit development
+During embryogenesis rapid accumulation of beta 3 mRNA begins at stage 14 (early neurula)
+Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues
+Expressed throughout development of the floral meristem, in all four floral whorls and as floral organs matured, limited to the ovule
+Expressed in the floral meristem even after the initiation of carpel primordia
+In the testis, expression is highest in fetal gonad and decreases 8-fold in newborn
+Expressed throughout the mesodermal (M) lineage from the 1-M stage to the 18-M stage, and in the sex myoblast (SM) sub-lineage from the 2-SM stage to the 16-SM stage, before the cells differentiate (PubMed:28614700). Expression declines significantly in the differentiated coelomocytes (CC) and vulval muscles, but remains in the differentiated body-wall muscles (BWM) (PubMed:28614700). Expressed in the vulval precursor cells (VPC) during larval development (PubMed:10926783)
+Up-regulated during meiosis (PubMed:16303567). Present from pre-meiotic DNA replication and disappears following meiotic prophase I (PubMed:23395004, PubMed:33825974)
+Accumulates progressively during tuber formation from stolon
+Expressed in early elongating spermatids during spermiogenesis
+Specifically expressed during brain maturation from 14.5 dpc to P2 by a subset of tangentially migrating interneurons. Barely detectable in adult brain. Isoform 1 expression peaks at P2 and remains high in adulthood compared to isoform 2. Expressed in preoptic area, hypothalamic regions and the first branchial arch at 9.5 dpc. Expressed uniformly in the odontogenic mesenchyme of the first branchial arch prior to initiation of tooth development. During odontogenesis expression is restricted to the mesenchyme participating in the formation of individual teeth. Expressed in olfactory bulb, arcuate nucleus, medial glanglionic eminence and preoptic area at 13.5 dpc and 14.5 dpc. Expression spread to the cortex and hippocampus at P1.0. Preferentially expressed in parvalbumin or somatostatin positive cortical interneurons
+Expressed at late stages of melanosome differentiation
+Expressed both maternally and zygotically
+Expressed during development
+Not detected before 13.5 dpc. From 13.5 dpc on, prominently expressed only in mesenchymal condensations and in cartilaginous tissues. In the ATDC5 cell line model, up-regulated during chondrocyte differentiation, absent in precondrogenic, non-differentiating stage (at protein level)
+Increased expression during seed filling, with a maximum between 33 and 38 days after anthesis
+Expression is first detected in the embryo at 8 dpc
+Expressed in adult but not in embryo
+Expressed throughout development
+Accumulates throughout roots vascular cylinders (PubMed:27354416). First observed early in the meristem, and later detected in procambial cells and phloem poles (PubMed:27354416). Absent from the xylem axis (PubMed:27354416)
+In interphase cells, it is localized in the centrosome. Decreases in metaphase and anaphase and reappears in telophase
+Expressed in tachyzoites (at protein level)
+Widely expressed throughout the anterior head region, including the central nervous system, the eye and branchial arches at 24 hours post fertilization (hpf). Expressed strongly in the brain region, with expression extending posteriorly in the spinal cord. By 40-48 hpf, expression remains strongly expressed in the head region but is reduced throughout the rest of the embryo (PubMed:30424580). Expressed in the heart and tail regions throughout developmental stages (PubMed:29174768)
+Maximum expression found during days 4 to 8 and days 8 to 12 after inoculation with an avirulent and a virulent pathogen respectively
+Expressed maternally and throughout embryogenesis. Expressed in the dorsal mesoderm at 6 hours post fertilization (6 hpf), and this expression is maintained in the axial mesoderm during gastrulation and early somitogenesis. Strongly expressed in the prospective neuroectoderm at 8 hpf. Expression persists in the neuroectoderm and increases in the tail bud at the end of gastrulation, at 10 hpf. Enriched in the prechordal mesoderm and developing notochord and in ventromedial regions of the brain and neural tube during the early somite stages. Expression remains elevated within the tail bud, forebrain, the midbrain-hindbrain boundary and in the developing otic vesicles as somitogenesis progresses
+Expression is clearly detected in ovulated oocytes and 2-cells embryos but decline day 3 morulae. Remains at very low levels between 2 dpc and 11 dpc
+Expressed at embryonic day (E) 10.5 in the growing edge of the limb buds. At 11.5 dpc, enriched in the apical ectodermal ridge of the limbs. By 12.5 dpc, expression assumes a digit-condensation pattern in the 4 limbs
+More than twofold more abundant in the small cell variant (SCV) stage than in the large cell variant (LCV) stage (at protein level). LCVs are more metabolically active than SCVs
+Expressed in cells of the central nervous system (CNS) from 8.5 to 11.5 dpc. Expressed in the hindbrain (in the rhombomere boundaries) at 10.5 dpc. Expressed in CNS (ventricular zone and spinal cord), peripheral nervous system (PNS, sensory cranial and spinal ganglia), olfactory and tongue epithelia at 13.5 dpc. Expressed in CNS, thymus, various epithelial cell types including the olfactory, tooth and tongue epithelia at 15.5 dpc
+Expressed during the development of the nervous system
+Expressed up to embryonic day 14 and specifically in the anterior pituitary during embryogenesis
+Expressed in all stages of tadpole development. In the tail, high levels found in the premetamorphic stage (levels 54-60). Levels decrease with tail resorption. In the hindlimb, low expression during limb morphogenesis (stages 54-56), increased levels with limb growth (stages 58-66). Levels increase only slightly during intestine remodeling
+Observed in young plants. In flowers, first detected in flower buds at the beginning of the floral stage 13. In petals, levels fade out during flower maturation do disappear at floral opening. Present in sepals and to some extent in stamen and carpel
+Expression is up-regulated between stages 14-18 (early neurula stages) and remains high until stage 30, decreasing only at stage 45
+Expressed in cortical plate neurons at 16 dpc. Expressed in the neocortex, including the cortical plate (CP) at 16.5 dpc, onward (at protein level). Expressed in brain at 13.5 dpc, onward. Expressed during embryogenesis in the vasculature
+Expressed in horizontal cell layer of the retina at early larval stages declining to undetectable levels later in development
+When the food/pheromone ratio is high, its level peaks during the L1 larval stage (PubMed:8910282). Expression is detected in larvae beginning 4 to 5 hours after hatching, through the four larval stages, and in adults (PubMed:8910282). Expressed in ASJ chemosensory neurons in males from the L4 larval stage (PubMed:31264582)
+Accumulates progressively in mature roots
+Expressed throughout development (PubMed:16920335). First expressed in embryos from the 1.5-fold stage (PubMed:16920335). Highly expressed during the L2 stage of larval development (PubMed:16920335)
+Present in the growth-arrested state, its abundance does not change significantly as cells move into and through the cell cycle
+Expressed throughout all stages of plant growth
+Could not be detected in embryos until neurulation. In developing embryos, the expression is restricted to neural crest derivatives
+Larvae and adults, but not in embryos
+During autolysis, associated with extracellular slime surrounding lysed hyphae
+In embryos, expressed in the central nervous system from stages 14 to 17. In third-instar larvae, expressed in the brain, ventral ganglion and midgut
+In seedlings, first expressed in petioles and leaf blades of the cotyledons as well as tops and bottoms of the hypocotyls
+Expressed in vegetative cells and heterocysts, although expression is substantial in both cell types, it is higher in heterocysts
+Expressed specifically in differentiating cells of the root
+Abundantly expressed during embryogenesis
+It is not expressed before 8-8.5 dpc (PubMed:1363541). At 8-8.5 dpc it is found on the entire epithelium of the somite (PubMed:1363541). At 9.5 dpc its expression is restricted to the sclerotome (PubMed:1363541). At 10.5 dpc it is found in sclerotomally derived cells including the vertebral and costal precursors (PubMed:1363541)
+Detected in primary follicles and continued to be expressed in follicles in the antral stage. The highest level of AMH expression is present in granulosa cells of secondary, preantral and small antral follicles <4 mm in diameter, whereas expression is lost from follicles at sizes >8 mm
+Weakly expressed at zygotene, highly at pachitene and disappears from late diplotene to anaphase. Pronounced peak at the G1/S boundary but does not show mitotic expression
+During embryonic stages 12.5 dpc and 15.5 dpc, highly expressed in skeletal muscle and cardiac tissue
+In the testis, expression is detected at 4 days postpartum (dpp) with a peak at day 10. Levels decrease between 14-18 dpp with an increase in the adult
+Expressed in adult animals
+Expressed in the excretory cell at the 1.5-fold embryonic stage and throughout larval development
+Expressed in fetal brain
+Expressed throughout development and in adult animals
+At 12.5 dpc expression is restricted to the developing mouse brain. High levels are detected in the cortical hem and the choroid plexus epithelium in the telencephalic midline by cells starting to differentiate (at protein level)
+Expressed in the germline from the L2 stage larva
+First expressed at stage 18. Expression increases through the early tailbud stage (stage 23) and remains relatively high throughout the remainder of development. All isoforms show similar temporal expression patterns
+Initial uniform expression becomes localized to two posterior ectodermal patches flanking the neural plate and later to the inner ectoderm of the developing tailbud. Also expressed in dorsal regions of the brain during tailbud stages and is especially abundant in the ventricular layer of the dorsal hindbrain caudal to the otic vesicle
+Ligninases are expressed during secondary metabolism, and are triggered by nutrient limitation
+Present in undifferentiated embryonic stem and germ cells; expression is lost when cells differentiate. In the developing testis, it is expressed at all stages. Present in all cells within the developing tubule, including gonocytes and spermatogonia (at protein level). It the developing kidney, it is confined to the nephrogenic zone in the cortical region, where the tips of the ureteric bud induce de novo formation of epithelia in the metanephric mesenchyme and early glomeruli. Expression is around 8-fold lower in adult kidneys
+Expressed in embryo from 7 to 17 dpc
+Expressed after 4 hours of development, reaches a peak at 8 to 12 hours, and then decreases
+Accumulates at the basal side and all corners of most cells in the primary root, lateral roots and embryos
+In myogenic progenitor cells, highly expressed at 11.5 dpc and ceases its expression at the late fetal stage (17.5 dpc)
+Weakly expressed in the testis of the embryo and neonate
+Expressed during late seed maturation
+Expressed at relatively stable levels until 12 hours of development and then goes up at the 14th hour and then decrease again
+Expressed in the progenitor domains for mesencephalic GABAergic neurons
+At 18.5 dpc, widely expressed with enhanced levels in brain, spinal cord, lung and kidney, including medulla and cortex. In the developing brain, strongly expressed in the neopallial cortex and throughout the cerebellum with intense expression within the developing Purkinje cells and adjacent choroid plexus. Strong expression also observed within the pons and throughout the medulla oblongata. In the lung, expressed in individual pneumocytes and particularly in cells surrounding developing bronchi/bronchioles. Moderate expression in chondrocytes of costal cartilage and in the surrounding perichondrium
+Expressed both maternally and zygotically. Expressed ubiquitously in the developing embryo. Strongly expressed in the somites and brain at 16 to 26 hours post-fertilization (hpf)
+Expressed throughout development and at reduced levels late in embryogenesis. Localizes to the embryonic cortex and to the metaphase furrows which separate mitotic nuclei in the syncytial embryo prior to cellularization. Concentrates in the leading edges of the furrow canals at the onset of cellularization
+Highly expressed in embryos and to a lesser extent in larvae (PubMed:16111945). Expressed in pharynx, seam cells and ventral nerve cord neurons at the L1 and L4 larval stages (PubMed:12958363, PubMed:16111945). Expressed in vulva cell precursors and somatic gonad at the L2 larval stage and in vulva at the L4 larval stage (PubMed:12958363)
+Expressed specifically in the embryo surrounding region at the micropylar end of the seed endosperm at early stages (4 to 7 days after pollination, DAP) and ever-decreasing parts of the suspensor at subsequent stages (at protein level)
+May be expressed at all postembryonic stages
+Expressed at all stages with highest levels in late-stage pupae and adults
+Expressed in the embryonic brain. Expressed strongly in the venricular zone (VZ), subventricular zone (SVZ), and lower intermediate zone (IZ) but weakly in the upper IZ and cortical plate (CP) at 14.5 dpc. At 16.5 dpc, expression increases in the IZ and CP. At 18.5 dpc, it increases significantly in the CP but decreases in the IZ, SVZ, and VZ (at protein level)
+Expressed in germ cells; along the cleavage planes at the vegetal pole of early cleavage stage embryos
+In newborn kidney, not detected at the vesicle stage. First detected in S-shaped bodies
+Highly expressed in quiescent cells
+During embryo development, expressed from torpedo stage onwards
+During embryogenesis, first observed at the heart stage. Expressed through the whole developing embryo from the torpedo stage. Disappears in the root tip of the mature embryo and in adult plants. In seedlings, mostly present in the shoot apical meristem and young leaves. In flowers, detected in sepals, stamens and pistils, but not in petals
+Expressed in the embryonic day 4.5 embryo (PubMed:23395635). Expressed in paraxial mesoderm and developing somites (PubMed:7729571). At 7.5 dpc, low expression is detected in a subdomain of the primitive mesoderm (PubMed:8041747). At 8.5 dpc, expressed at high levels throughout the uncompartmentalized epithelial somites and in the rostral paraxial mesoderm (PubMed:8041747). By 9.5 dpc, expression is confined to the somite and is most prominent in the myotome and dermatome (PubMed:8041747). At 10 dpc, expression in somite declines in the myotome but persists at high level in the dermatome (PubMed:8041747). At 10.5 dpc, expression is seen only in the somites in the caudal portion of the embryo (PubMed:8041747)
+Expressed from the embryonic stage to adulthood. Expressed in embryos from the 1.5-fold stage, with expression increasing to the 3-fold stage. Expressed in ciliated cells including amphid and both inner and outer labial neurons of the head at larval stages L1 and L2. Expressed in both phasmid neurons PHA and PHB in the tail and in the PDE sensory neuron in the mid-body at larval stage L3 and L4
+Expressed from late M until late S-early G2 phases
+Increasing expression during seed development followed by a rapid degradation during the first days of seed germination
+Expression increases markedly from days 9 to 11 in the developing embryo, followed by a gradual decrease up to birth
+Expressed at very low levels throughout the life cycle
+Most abundant in midgestation embryos (day 9.5). In embryonic lung expressed at 12 dpc and 18 dpc with highest levels in proximal airways and lowest levels in the distal lung
+During seed germination, expression increases in the embryo from 3 to 48 hours after seed imbition, with a peak at 48 hours
+Expressed at all developmental stages, though the levels vary
+Isoform 1 and isoform 2 are expressed from stages 8.5-19 dpc
+Expression increases in abundance during postembryonic development and peaks during the fourth larval stage
+Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E
+Expressed during sporulation
+Expression detected in differentiated mature adipocytes, with levels increasing during late stage adipocyte differentiation (PubMed:17250804, PubMed:29343498). Low expression is detected in preadipocytes, mainly localized in primary cilium (PubMed:31761534). Expression level in bone marrow mesenchymal stem cells is gradually increased during differentiation toward osteoblasts (PubMed:26365922)
+Expression is observed in embryos as early as the 20-30 cell stage and persists throughout development and into adulthood
+Appears late in development, just before the villus transition in intestine morphogenesis. Restricted to the epithelial compartment in both adult and fetal intestine
+In C2C12 cell line, increased expression during myotube formation and differentiation in culture
+Expressed during pollen development. At the immature, bicellular stage, expressed exclusively in the intine. At the mature, tricellular stage, expressed at the boundary of cytoplasm and intine of the pollen grains, specifically in the region of the germinal apertures. The strongest expression at the mature stage is shown under normal environmental conditions. After germination, expressed at the tip region of the pollen tube
+Low in adult brain, much higher in younger animals
+Expressed in numerous tissues including the CNS throughout most of embryogenesis
+Expressed in subepidermal cells of anlagen regions, then in abaxial part of primordia and finally in differentiating organs. Levels decrease in differentiated organs. In embryo, expressed from the heart stage in the abaxial domain of the cotyledon primordia and decrease as the embryo matures. In stamen, expression restricted to the abaxial region differentiating into the connective. In gynoecium, expressed in the abaxial cell layers differentiating into the valves
+In the brain it is localized in many neurons at 1-2 weeks after birth, whereas in mature animals it is localized to tissues of the blood-brain barrier
+Expressed in trophoblast and vessel endothelial cells of the placenta and in the brain at 14.5 dpc (at protein level)
+Observed in root cap cells
+Detected in the eggs and stronger expression in later instars. The strongest signals were detected in the fifth and sixth instars as well as in adults
+Detected at 19 dpc in embryo
+Expressed at 10 hours post-fertilization (hpf), reach peak levels at 48 hpf and is not detectable in adult tissues. Expressed during neurogenesis between 9 and 72 hpf and in ventral endoderm region where pancreatic progenitors originate
+3 EF-1-alpha are expressed under different developmental control in Xenopus laevis. This protein is expressed in embryos beginning at the mid-blastula transition and in adults cells
+Preferentially expressed in primordial germ cells (PubMed:23154982). Ubiquitously expressed in the embryo (PubMed:22865833)
+At 13.5 dpc is widely distributed in the forebrain, midbrain, hindbrain, spinal cord, somites, developing limb buds and skin
+Expression is detected as early as the larval L1 stage and continues into the adult stage
+Expressed in the heart from 11.5 dpc. Gradually increases in skeletal muscle to 18.5 dpc
+Expressed in retina, retinal pigmented epithelium, Rathke's pouch, corneal epithelium, the infundibulum and olfactory placodes at 10.5 dpc (at protein level). Expressed in the inner region of the neural retina, including the ganglion cell layer at 17.5 dpc (at protein level). Expressed in the optic sulcus and in the pre-tectum at 8.5 dpc. Expressed in the optic vesicle, in the midline position in the roof of the midbrain and in the pre-tectum at 9.0-9.5 dpc. Expressed in the olfactory placodes at 10.5 dpc. Expressed in retinal-pigmented epithelium and in the neural retina, with strong expression in the ciliary margin at 12.5-13.5 dpc
+Expression begins at 9.5 dpc in cranial ganglia, dorsal root ganglia and neural tube. At 10.5 dpc, broadly expressed in the intermediate zone of the hindbrain, spinal cord and dorsal root ganglia. By 12.5 dpc, expression in the spinal cord becomes restricted to a narrow band of cells in the ventricular zone
+Expressed throughout embryonic development. In adults, expression is higher in females than in males
+During germination, abundant up to fourteen hours after imbibition. Levels decrease slightly after this and then gradually increase again
+Expressed in larval stage L3 male and hermaphrodite germlines, coinciding with sperm fate specification (at protein level) (PubMed:22570621). Expression persists throughout adulthood in males, but is absent in adult hermaphrodites that are undergoing oogenesis (at protein level) (PubMed:22570621)
+Expressed during embryo development
+Detected in the embryo, but not in the suspensor, up to the globular stage
+Expressed both maternally (isoform C) and zygotically (isoforms A and C) in all developmental stages
+Expressed throughout development (PubMed:8970152, PubMed:12783787, PubMed:22293500). First expressed in several posterior cells of comma stage embryos (PubMed:12783787). Expressed in the excretory cell and in some head neurons in threefold stage embryos (PubMed:12783787). At the L1 stage of larval development expressed in the syncytial hypodermis (PubMed:8970152). From the L1 stage of larval development to adulthood, expressed in head neurons, the excretory cell, excretory gland cells and in the sphincter muscle (PubMed:12783787, PubMed:22293500). From the L4 stage of larval development to adulthood, expressed in hypodermal cells surrounding the vulva (PubMed:12783787)
+Highly expressed during leaf senescence
+Expressed during vegetative growth and throughout development
+Expression increases in senescent cells
+Expressed in the embryonic retina from 14 to 17 dpc (at protein level) (PubMed:26766442). Expressed throughout neuroectoderm at 7.5 dpc (PubMed:15567712). The expression increases in rostral brain and caudal neuropore regions and decreases in hindbrain and spinal cord regions (PubMed:15567712). At 12.5 dpc the expression is found in undifferentiated neuroepithelium in ventricular zone, dorsal root ganglia and several non-neural tissues (PubMed:15567712)
+Expressed throughout development (PubMed:20876647). In embryos, first expressed in neuronal precursor cells during gastrulation (PubMed:20876647). At the comma and 1.5-fold embryonic stage, expressed in neurons in the head, the tail and along the ventral cord (PubMed:20876647). In 1.5-fold stage embryos, expressed in the nerve ring bundle (PubMed:28846083). At the L1 larval stage, expressed in the ventral nerve cord and in a subset of dorsal D-type GABAergic motorneurons (PubMed:22442082, PubMed:23376536). At the L2 larval stage, expressed along the ventral nerve cord (PubMed:23376536). Not expressed in ventral D-type GABAergic motorneurons at the L2 larval stage (PubMed:23376536)
+First detected at the late gastrula stages around 9 hours post-fertilization (hpf). Expression intensifies by the end of gastrulation around 10 hpf, continues into early somitogenesis stages around 12 hpf and persists in the somites until 96 hpf when the somites give rise to the trunk skeletal muscle
+Detected in seedlings 6 hours and 2 days post-germination
+At 12 dpc, only isoform 1 is seen while at 16 dpc and 18 dpc, isoform 1 and isoform 2 are seen. In the adult brain expression of isoform 2 increases dramatically as compared with its expression in embryonic brain where as isoform 1 decreases to undetectable levels
+Specific expression was elevated in mid-gestation stages, particularly developing liver and spinal cord
+Expression begins in the embryo and diminishes in larvae (PubMed:16310763). Expressed in the excretory duct cell, as well as other cells, at larval L3 stage (PubMed:16310763)
+Expressed in four-cell stage embryos
+Expressed in early embryonal epithelia
+At the cellular blastoderm stage, expressed in 8 segmentally repeated stripes, and 14 stripes at germ band extension (at protein level) (PubMed:12617819). Expressed in the neurogenic region during the blastoderm and germ band extension stages (at protein level) (PubMed:12617819). Expressed zygotically (PubMed:12617819). Expressed throughout development, with two peaks of expression at mid-embryogenesis (6-12 hours old embryos) and in early larvae stages (PubMed:10973475). First detected in the cellular blastoderm as two distinct anterior and posterior bands (PubMed:12588858). By germband retraction (late stage 12), segmentally repeated stripes span the width of the germband (PubMed:25363762, PubMed:12588858). In embryos (stages 12-15), detected in ectodermal cells that surround differentiating neurons of the ventral nerve cord and peripheral nervous system (PubMed:12588858). In third instar larvae, expressed at high levels in the tracheal epithelium, and at relatively lower levels in the gut and fat body (PubMed:22022271). In the wing imaginal disks, expressed in the proximal region around the wing pouch and noctum, and in the hinge regions (PubMed:17078066, PubMed:21158756). Also expressed in the anterior compartment of the leg imaginal disks (PubMed:21158756). In larvae, detected in the blood cells, lymph glands and fat body (PubMed:12617819). In third instar larvae to the pre-pupae stage, high levels of expression across the lateral noctum except where dorsocentral and scutellar bristles form (PubMed:18000549). In late stage third instar larvae, expressed throughout the lateral noctum epithelium, except for the SOPs (anterior postalar, supraalar and sensilla trichoidea) in which expression decreases as SOPs develop (PubMed:18000549)
+Expressed during the later stages of sporulation
+Maternally expressed in the embryo: maternal expression is ubiquitous
+Expressed in larvae. Expressed on all days from the fourth through the sixth instar, with the highest expression in the fifth instar. The level varies in the sixth instar with reduced levels observed on the first day, significant on the next day, and diminished levels on the following two days. The maximum level is observed during the active feeding period
+Expressed progressively with the aging of the plant
+Expressed at highest levels in the spinal cord at embryonic day 9, expression remains high at postnatal day 7 (P7), become weak at P14 and is not detectable at two months (at protein level)
+Accumulates steadily during G2 and is abruptly destroyed at mitosis
+Initially expressed in visceral endoderm and becomes restricted to primitive streak and nascent mesoderm at gastrulation. This includes the hemangioblast, a precursor of hematopoietic and vascular stem cells. At 5.5 dpc, it is expressed symmetrically in the visceral endoderm but by 6.0 dpc this expression is noticeably asymmetric. At 6.5 dpc, expression is restricted to the nascent primitive streak and persists in the primitive streak through 7.5-9.5 dpc, marking those cells fated to form extra-embryonic and lateral mesoderm
+Strong expression in flowers as well as in senescing leaves
+Expressed at 15.5 dpc in the nonsensory epithelium of the inner ear and at lower levels in the vestibule of the inner ear, the brain and hair follicles. Expressed in the ganglion cell layer of the retina and in the ciliary body at 15.5 dpc. At later stages, retinal expression becomes restricted to the ganglion cell layer
+Tenfold increase in expression between 4-cell and 12-cell embryos
+Accumulates during senescence
+Highest expression in vegetatively growing cells. The level of expression falls steadily throughout multicellular development and are not found in dormant or germinating spores
+Found in the embryo at day 7 dpc, 11 dpc, 15 dpc, and 17 dpc. At the limb bud formation stage 11 dpc, it is expressed in fore- and hindlimb buds, branchial arches, and facial primordia
+In seedlings, mostly present in the shoot meristematic region, as well as in the vasculature of the hypocotyl and root. Expressed in both primary and lateral root vasculature. In flowers, accumulates in sepals, stem, carpel tissue and anther filaments
+Expressed during the asexual blood stage, specifically during the trophozoite and schizont stages (at protein level)
+Primarily present around the midvein in seedlings. Accumulates gradually in expanding leaves, reaching a maximum in fully expanded leaves in the primary vein
+Expressed in the central nervous system as early as 24 hours post-fertilization
+Tailbud onwards
+Expression differentially regulated in the posterior and middle silk glands during the fourth molt/fifth intermolt
+Detected at low levels throughout development. Highest expression levels are seen in embryos
+Expressed from oocyte to tadpole stages. Expressed in all animal, marginal and vegetal parts of blastula embryos. Expressed broadly in the head, trunk and tail region of tadpoles. Expressed in the midline at the neurula stage; the signal is detected in the notochord, neuroal tube and cement gland
+Expressed throughout development (PubMed:19018662). Expressed in the embryonic CNS midline (at protein level) (PubMed:23892553). Also expressed in various longitudinal muscles (at protein level) (PubMed:23892553). In embryos, expressed in the CNS midline and in the muscles (PubMed:19018662). In larvae, expressed in the lamina of the optic lobe (PubMed:19018662). Expressed in larval body wall muscles (PubMed:24124519)
+Expressed most strikingly in selected ventricular cells lining the spinal cord and brain. The level of expression decreases dramatically as the cells differentiate into neurons and migrate to the outer layer of the spinal cord and brain. Expression is observed during development in a restricted region of the nasal neuroepithelium
+Expressed in hypodermal cells and seam cells, in the larval L4 stage, and in the young adult (PubMed:24569038). Not expressed in the cells of the developing vulva (PubMed:24569038)
+Expressed at high levels throughout development, lowest level is in larvae
+Expressed during the asexual blood stage (at protein level)
+Expressed in the lateral hypodermal (seam) cells and occasionally in the hyp7 hypodermal cell during the larval stages of development with increased expression during the molting phase between the L3 and L4 stages of larval development. Also expressed in the vulval precursor cell desecendents of P5.p, P6.p and P7.p cells
+Found to be expressed throughout the ovarian cycle
+Expressed during summer
+Not detected in resting oocytes. As oocytes begin to grow, levels increase to reach a maximum in midsized oocytes. Levels decrease in later stages of oocyte growth
+Expressed in the P lineage during embryogenesis (PubMed:18202375). First expressed at the 4- to 8-cell stage, and expression remains throughout the remaining P cell divisions in P2, P3 and P4 cells, and subsequently in primordial germ cells Z2 and Z3 (PubMed:18202375). Expression begins to diminish at the 100-cell stage (PubMed:18202375)
+Higher levels in developing tissues
+Expression begins at S phase, accumulates in late S/G2 phase and disappears in G1 phase
+Expressed both maternally and zygotically. Expressed throughout embryogenesis
+At 14.5 dpc embryo found at high levels within the forebrain, olfactory epithelium and olfactory pit. At 12.5 dpc embryo detected on olfactory axons including olfactory pathway on which the LHRH neurons move. From 11.5 dpc to 17.5 dpc embryos expressed in LHRH (luteinizing hormone-releasing hormone) neurons as they migrate from the olfactory pit into the developing forebrain
+Expressed both maternally and zygotically. Predominantly expressed in the adult. Weakly expressed in the embryo, L2 and L3 stages, and almost absent in L1 stage larvae
+Most abundant prior to premeiotic S-phase, remains high from karyogamy to early pachytene, declines drastically by late pachytene and diplotene, and is undetectable by sterigma stage
+At 10.5 and 12.5 dpc, expressed in the central nervous system. At 14.5 dpc, expressed in the eye (lens and inner neural layer of the retina), in the primitive glomeruli of the developing kidney, in the villi of the gut and in the dorsal root ganglia
+Within the nervous system, expression is restricted to prosomeres 1 and 2 in the diencephalon and all the rhombomeres in the hindbrain during segmentation stages. Later on, a superimposed pattern appears that correlates with the formation of several axonal tracts. In the somitic mesoderm, the expression correlates with segmentation and the guidance of both neural crest and motor axons through the sclerotomes
+In the CNS, it is expressed in the developing neural tube starting from 10.5 dpc in the spinal cord and around 11.5 dpc in the telencephalon. Expressed ubiquitously throughout the spinal cord and telencephalon during neurogenesis. Expressed throughout the developing retina at 15.5 dpc. Not expressed in the somite or presomite during somitogenesis. Expressed slightly earlier that Dtx1 and Dtx3
+Not expressed maternally. Low levels from 13-24 hours post-fertilization (hpf). Also expressed in adult
+Expressed during oogenesis from stage IV onwards and throughout early embryonic development
+Mainly expressed in all hypodermal cells (hyp1 to hyp11) from the tip of the head to the tip of the tail from late embryogenesis to adulthood, and expressed in the excretory duct and pore cells from the 3-fold stage of embryogenesis to adulthood. Expressed in intestinal and rectal cells, sensilla support cells, and transiently in the P lineage during the L1 stage of larval development. Temporal expression during the molt phases from larval development stage L2 to L4 with high expression prior to and during the L2 and L3 molt, but low expression between the molting phases, and low expression after the L4 molt
+Expressed in early developing glial cells of the embryo and accumulates between the embryo and the eggshell
+In leaves, especially present in stomata guard cells. In reproductive organs, expressed in pollen grains and tubes of germinating pollen, as well as in funiculi attaching seeds to siliques
+Rises dramatically during early development
+Expressed from early embryogenesis (at protein level) (PubMed:31147388). During early embryogenesis, expressed during prophase and interphase in 2- and 4-cell embryos (PubMed:31216475)
+Levels are highest one week after planting
+Very early blastula (between 16-cell stage and hatching)
+Levels of expression in fibroblasts decrease heterogeneously during cellular aging (PubMed:11302691). In CD4(+) T cells, expression increases during polarization towards T-helper Th17, Th1 and Th2 (PubMed:31899195)
+Induced during sporulation
+On day 14 or 17 of embryonic development. Expression is observed in germ cells at the stages of late pachytene spermatocytes through to early round spermatids
+Detected in all developmental stages: log phase promastigotes, metacyclic promastigotes and axenic amastigotes
+Detected at embryonic day 16 (16 dpc) in the striatum. From 16 dpc to 20 dpc to adulthood, the highest expression levels of protein is observed in the striatum, olfactory tubercle, nucleus accumbens, amygdala, and neocortex
+Remains repressed throughout pregnancy and becomes highly and rapidly expressed before parturition
+Not expressed during sporulation
+At 24 and 48 hours post fertilization, expressed only in the heart
+Partially colocalizes with FREY1 in endoplasmic reticulum membrane of round spermatids
+Expressed only from 5 days post germination onward, when the fixed meristem cell number is established
+Accumulates in developing seeds during dry weight deposition and desiccation tolerance acquisition. Disappears after germination
+Expressed specifically in the S phase during the plant cell cycle
+Expressed at maximal levels in early embryos (6-12 hours). Expressed at lower levels during development
+Expressed during the early stages of leaf development and expression decreases with the maturation of the leaf
+Specifically expressed during early development: expression starts to increase at the 4-cell (4C) stage and culminates at the 8-cell (8C) stage
+During midgestation, enriched in the frontal and anterior temporal cortices. Expressed at high levels in the exterior margins of the thalamus, ventromedial striatal neuroepithelium and anterior cingulate
+Copolarizes with BASL and MPK3/MPK6 in stomatal asymmetric cell division (ACD) cells
+Up-regulated during xylem vessel element formation. Expressed preferentially in procambial cells adjacent to root meristem
+Expressed in the forebrain, and in the prospective midbrain/hindbrain boundary during early somitogenesis. As development proceeds, also detected in the hindbrain, as well as in the apical fold of the developing pectoral fin, and this expression extends proximally
+In larval salivary glands, not detected until 23 hours after puparium formation (APF), prior to the onset of salivary gland histolysis (at protein level) (PubMed:25836674). In larval salivary glands, not detected until 20 hours APF, then expression levels dramatically increase 23 hours APF (PubMed:25836674). Expressed in the larval midgut, at the 3rd instar wandering stage, with expression levels increasing at 0 hr APF after the ecdysone pulse (PubMed:25836674). At 3 and 5 hours APF, expression levels in the midgut reduce slightly but remain elevated compared to expression levels in 3rd instar wandering larvae (PubMed:25836674). In embryos, expressed in the embryonic brain and midgut (PubMed:25836674)
+Expressed in the presomitic mesoderm preceding the formation of somites. At stage 4 expressed in and around the primitive streak. During subsequent development, expression domain persists, and gradually retracts in parallel to the retracting Hensen's node towards the caudal end. Expression begins to accumulate in gastrulating mesoderm and is later restricted to paraxial mesoderm, prior to the onset of somite formation. No expression is seen within somites, nor in the tailbud mesoderm
+In roots, restricted to the endodermis/pericycle above the middle of the differentiation zone and the regions where new lateral roots are emerging (PubMed:21558309). Accumulates in the abscission zone of young siliques (PubMed:21558309, PubMed:23893219). Expressed in senescing leaves (PubMed:23893219)
+Levels remain unchanged during day 20 embryo to 4 weeks post-hatch
+A 10-fold increase in expression levels is seen by 1 week post-hatch and declines slightly between 3 and 4 weeks post-hatch
+Expressed in the procyclic and bloodstream forms (at protein level)
+In the developing brain, expressed at low levels from 10 dpc stages to young adulthood (P25) with peak levels from 14 dpc to P8. In the cortex, first expressed uniformly in all cells at 14 dpc. Not expressed in the retina. Highly expressed in fetal liver progenitors at 12.5 dpc
+Expressed in embryonic stem (ES) cells
+Expressed in embryos (at protein level)
+Expression is initially low during the vegetative stage, but increases after 5 and 15 hours of development. Up-regulation of the expression at the postaggregative stages is observed
+At all stages, expression corresponds to the localization of SHH. First detected during gastrulation. By 36 hours, PTC1 appears in the first branchial arch and the posterior mesenchyme of the fin bud; by 48 hours, in the hindbrain and foregut
+Transient induction with an apparent maximum occurring 6 to 8 days after subculturing
+First expressed shortly after the mid blastula transition. Most abundant during gastrulation (stages 10 and 12)
+First detected in 4 hours embryos, expression persists throughout embryogenesis, levels drop during larval stages and then increase again during pupal and adult stages
+Expressed in aleurone layers of germinating seeds 4 days after imbibition (PubMed:12684786). Expressed in developing seeds from 25 to 35 days after flowering (PubMed:12684786)
+Expressed in cumulus cell-oocyte complexes during expansion
+Accumulates in young leaves but fades out during leaves aging
+Present at high levels in embryos and L1 animals but is undetectable at later stages
+Expressed in 10-day-old seedlings
+Expressed during endosperm development with a peak at approximately 12 days after fertilization (DAF) and then gradually declines from 15 DAF
+Developmental protein. During segmentation it shows a cyclic transcription pattern which is under the control of Notch. Expressed in the caudal region of the presomitic mesoderm with each cycle corresponding to the formation time of one somite. In the dental epithelium it is detected at stage 13.5 dpc. The pattern of expression corresponds exactly to the formation of the enamel knot between late bud and early cap stages
+In day 11 embryo, expression is almost exclusively seen in endothelial cells of the intersegmental blood vessels separating the somites, the atrial and ventricular chambers of the heart, and the dorsal aorta. High expression also occurs in extraembryonic membranes. In the developing brain of day 13 embryo, endothelial cells of the highly vascularized choroid plexus contain high levels of EPAS1
+First detected at 9 dpc
+Expressed in developing embryo. At globular stage, expressed in all cells of the embryo proper. At heart stage, preferentially expressed in the protodermal tissue. In mature embryo, expressed in the provascular tissue, root cap and mature epidermis. Expressed in the aleurone layer in mature seed. Expressed in leaf primordia and shoot apical meristem (PubMed:22026387)
+Expressed from early embryogenesis (at protein level)
+Expression is high in adult, but very low in neonate dorsal root ganglion neurons (at protein level)
+First detected at 7 days post conception (dpc) and is also present at 11 dpc, 15 dpc and 17 dpc with the highest level at 15 dpc. Expression in whole brain is detected from 14 dpc to adult. Expression in cerebellum appears maximal at 18 dpc and postnatal days 5 (P5), whereas expression in cerebral cortex appears maximal at 16 dpc and 18 dpc
+Preferentially expressed at early stages of myeloid differentiation of highly purified CD34+ cells
+Increased levels found from the tight aggregation stage onward. Levels stayed high during late development. Clear expression at 24 hours when fruiting body formation is close to completion
+Expressed in the nucleus of distal tip cells until larval stage L4 when expression decreases onwards to late adulthood
+Expressed during embryogenesis (PubMed:33238150). Expressed in EA and EP endodermal precursor cells at the 16-24 cell stage of embryogenesis (PubMed:33238150)
+Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases
+Expressed in seedlings and all organs of adult plants (PubMed:21954461). In roots, present in endodermis and central cylinder (PubMed:21954461). In flowers, detected in stigmatic papillar cells (PubMed:21954461). When petals and sepals are withering, accumulates in the abscission zone at the bottom of the silique (PubMed:21954461). Later observed along the valve margin-replum boundary, where dehiscence and pod shatter occur (PubMed:21954461)
+Highly expressed in the early globular stage embryo before 2 days after pollination (DAP), as well as in the endosperm. At 3 DAP, expression is down-regulated in the central region and in the center of the ventral region of the embryo, where the shoot subsequently forms, but weakly expressed in other regions until 4 DAP, and then disappears after 4 DAP. During transition between the inflorescence and floral phases, expressed in the inflorescence meristems but not in the floral meristem
+First detected at low levels in the germarium region 2B where it is concentrated in the pro-oocytes (at protein level) (PubMed:11546740). Remains concentrated in the oocyte until mid-oogenesis (at protein level) (PubMed:11546740). In early egg chambers detected in nurse cells and oocytes, and later accumulates at the posterior pole of stage 10 oocytes (at protein level) (PubMed:11546740). Expression decreases during the first 5 hours of embryogenesis; expression levels are high during the first 2 hours of embryogenesis then sharply decrease at 2-3 hours and remains low (at protein level) (PubMed:28875934). Ubiquitously expressed in cleavage embryos but is not detected at the cellular blastoderm stage (at protein level) (PubMed:11546740). Expressed both maternally and zygotically (PubMed:1900936)
+Strongly up-regulated during leaf senescence
+Initially expressed at gastrula stages. Expression peaks at neurula stage, and is maintained at stable levels through tailbud stages
+Only expressed in embryos
+Present in aerial hyphae of sporulating cultures (at protein level)
+Activated early in development in aboral ectoderm cells
+Up-regulated in aspidocytes, environmentally resistant cell types
+Significantly increased in the cells during progression to the S and M phases, and becomes barely detectable in the early G(1) phase by a proteolytic control during mitotic exit
+Expressed at 9 dpc in placenta and at weaker level in uterus. High expression in neural tube and in CNS throughout development. High expression in sensory ganglia and retina from 11 dpc. In the alimentary tract and olfactory epithelium expression was seen from 13 dpc. Strong expression present in liver and kidney, from 11 dpc and 13 dpc respectively, and then expression decreased at later stages of development. Moderate expression in lung from 13 dpc, while it decreases during postnatal life. Strong expression in thymus from 15 dpc onwards, and in spleen from 17 dpc and during early postnatal life, then, the expression decreases
+Expressed in the brain and spinal cord at 14.5 dpc (at protein level)
+Tends to mark the dorsal ectodermal and mesodermal cells. Initially expressed in the dorsal-lateral ectoderm, and subsequently extends through the entire neural plate at the neurula stage. Also expressed in the prechordal plate. Prechordal plate mesoderm specifies anterior neuroectoderm and pharyngeal endoderm, which are progenitors for the formation of head structures. At the hatching stage, enriched from the dorsal mesenchyme to the olfactory pit and optic cup
+Expressed at substantial levels throughout development with some slight variations
+In reptiles, the alpha-D chain occurs in a minor hemoglobin component, called hemoglobin d, which is expressed in late embryonic and adult life
+Expressed during synaptogenesis in the retina (at protein level)
+Expressed both maternally and zygotically. Expression declines considerably at the end of gastrulation but continues at a low level until the tadpole stage (stage 38)
+Expressed maternally in 2-cell embryos, zygotically in early and mid-embryogenesis; expression decreases after gastrulation and is abolished in L1 larvae, but re-expressed in the adult gonad
+A uniform expression is seen in unfertilized eggs, embryos, larvae, pupae and adult flies. Expression during embryogenesis is restricted to the CNS and the Garland cells, a small group of nephrocytes that takes up waste materials from the hemolymph by endocytosis. In post-embryonic stages, expression is seen in the larval salivary glands and the CNS, and in the adult CNS and reproductive systems
+Expressed throughout seed development, from 25 days after fertilization (daf) until full maturation and drying at 105 daf. Decreases rapidly after imbibition
+Expressed at high levels in germinal vesicle (GV) stage oocytes and at lower levels in MII-stage oocytes and zygotes (PubMed:24357321). Expression decreases from 4-cell stage to blastula (PubMed:24357321)
+Increases during conidiation
+Detected from 6 to 12 dpc in whole embryos and from 14 to 18 dpc in the heads of the embryos. Expressed in central nervous system, spine, face, pharynx, limbs and viscera at 11 dpc
+Expressed during G2/M and M phases
+Maternally transcribed, with constant expression during early stages of embryogenesis. Levels increase at the end of gastrulation and are maintained during neurulation and organogenesis. During later stages expressed in somites, segmental plate, brain, branchial arches, eyes and ventral bood islands
+Expressed in ventral neural tube and axonal projections at 12.5 dpc-13 dpc (at protein level)
+Expressed during prophase I of meiosis
+During embryo development, expressed in a punctate pattern from the globular stage to the torpedo stage
+Expressed in developing grains
+Cell cycle-dependent expression. Not detected in G0 cells, starts to accumulate in early S phase, reaches the highest level in the G2 phase, and drops to very low levels at mitosis
+Probably maternally supplied, the zygotic expression becomes significative at 2.75 hpf and remains constant until 24 hpf
+Accumulates to high levels in mouse intestinal crypt epithelium during postnatal development
+Expressed in roots soon after germination, but decreases 7 days after germination
+Expressed only in embryos
+During early embryogenesis, expressed during prophase and interphase in 2- and 4-cell embryos
+Expressed in the central nervous system in a region-specific manner from the middle stage of embryogenesis to the adulthood in the rodent
+Expressed in the growing regions of roots, internodes and leaves
+Expressed maternally in oocytes and 0-6 hours old embryos (at protein level)
+Expression is developmentally restricted, peaks at the blastoderm stage (2-4 hours) and then disappears (at protein level)
+First detected in neurula (stage 16/17). Highest levels in whole tadpole found around stage 47/48. In the intestine, increased levels are found during metamorphosis (stages 58-64) and in the hindlimb, expressed at low levels during metamorphosis until stage 66 when levels dramatically increase. In the tail, a constant high level of expression is found throughout metamorphosis
+Detected in young expanded leaves emerging from the culms (PubMed:18774969). In young panicles, accumulates in spikelets and panicle branches (PubMed:18774969). Under short days (SD), observed in leaves by 1 week after germination and reaches a peak by 2 weeks. Subsequently, the level gradually decreases, but maintains at low levels even after flowering (about 9 weeks) (PubMed:18790997). Under long days (LD), present in leaves at low levels during all developmental stages from at least 1 week after germination (PubMed:18790997)
+Broadly expressed in late embryonic and early postnatal cerebellar neurons, including premigratory granule neurons of the external granule cell layer. Expression is maintained in neurons of the internal granule cell layer after migration is complete. Expressed in Purkinje cells throughout development. Expressed in Bergmann glial scaffolds used by granule cells during early posnatal radial migration
+Low expression is found in fetal liver
+Predominantly expressed during S- and G2-phases and early M-phase (PubMed:23042605). It then drops, and is probably degraded by the APC/C complex (PubMed:23042605)
+In seam cells, expression is first detected in late embryos, persists to the fourth larval stage and disappears in adults. In glandular cells g1 and g2, expression begins in the first larval stage and remains visible until adulthood
+A low level of expression is observed in all tissues. Highly specific expression was observed in organs with physiologic DNA double strand breakage (DSB), such as testis, thymus and spleen. Enhanced expression is also found at sites of high proliferative activity. These are the subventricular layer of the telencephalon and the diencephalon, the liver, lung, kidney and gut, as well as striated and smooth muscle cells in various organs
+High expression at 14 dpc. Sharp decline in expression between 16 dpc and 18 dpc. Absent in adulthood
+Expressed both maternally and zygotically. Expressed throughout development, with very weak expression between stages 10-16 of embryogenesis and weak expression in adults. In stage 5-6 blastoderm and gastrulating embryos, expression is uniform. In stage 16-17 embryos, expressed in the ventral and dorsal epidermis, posterior spiracles, foregut, hindgut, sensory nervous system primordium, pharynx and respiratory system. In larvae, expressed in the posterior spiracles and tracheal system. In pupae, expressed in the wing imaginal disks
+Detected in 32-cell embryos, probably due to perdurance of maternal transcripts. Has low expression at the 90% epiboly and tailbud stages (9-10 hours post-fertilization, hpf). Moderately expressed from 24 hpf onwards, and strongly expressed at the adult stage
+Expression begins in day 11.5 dpc embryos, and is localized in both the rostral spinal cord and rhombencephalon. In 12.5-13 dpc embryos, it is found throughout the telencephalon. By day 17.5, JNK3 is also expressed in neurons of dorsal root and sensory ganglia and at lower levels in neurons of the myenteric plexus and the developing heart
+Expressed on zygotes and ookinetes
+First detected at 12.5 dpc in the nervous system and in the dorsal root ganglia of the trunk region. By 15.5 dpc, strong expression in trunk and dorsal spinal cord and at 17.5 dpc expression increases in the dorsal horns
+Specifically expressed in postmeiotic phases of spermatogenesis
+Major secretory product synthesized by the sheep conceptus between days 13 and 21 of pregnancy
+Expressed ubiquitously (PubMed:16291785). Earliest expression is at the 50-cell stage, and persists throughout embryogenesis, larval stages and adulthood (PubMed:16291785)
+Expressed during vegetative to reproductive phase of development, with the main expression occurring in early flower development
+Expression decreases during stationary and autolytic stages
+Larvae and adult, but not eggs
+Expression is higher during stationary phase than during logarithmic growth
+Expression peaks at P7 in the brain. Expressed in inner hair cells from 19 dpc onwards
+Expressed during the process of ciliated cell differentiation. In seminiferous tubules of the testis, its expression is stage-specific and is highest in spermatocytes and round spermatids
+Embryo (at protein level) (PubMed:21447556). Expressed throughout development with highest levels of expression in 3rd-instar larvae and adults (PubMed:21447556). Expressed throughout the whole early embryo including the pole cells (PubMed:21447556)
+Expressed at the amastigote life cycle stage (at protein level). Expressed at the epimastigote, amastigote and trypomastigote life cycle stages
+Up-regulated during differentiation in primary cultured rat brown preadipocytes
+Expressed widely in developing cortex
+Highest levels are observed from day 11 to day 20, with peak levels on day 13
+Expressed only in fully differentiated cells of the egg apparatus. Not detected in developing ovules undergoing megasporogenesis or megagametogenesis (PubMed:19028964). Expressed in unfertilized, mature ovules (PubMed:20163554)
+Expression is cell cycle-dependent and peaks at mitosis
+In testis, expression increases upon transition of premeiotic type B spermatogonia into the early stages of meiosis as represented by preleptotene spermatocytes (PubMed:17681941). Continues to increase through the leptotene and zygotene spermatocyte stages, peaking in early pachytene spermatocytes (PubMed:17681941). Expression decreases in late pachytene spermatocytes and in later round spermatids (PubMed:17681941)
+First observed in young floral meristem before organs initiation. Accumulates strongly in the sepals of the early stage bud. In more mature buds, expressed on the adaxial side of the sepals, in the petal primordia, and transiently in young stamen primordia
+Widely expressed from embryo through to adult stages; peak expression levels seem to occur during larval stage L2
+Expressed during auxin-induced lateral root formation
+Expressed in vegetatively growing cells and during development
+Present at high levels during the first 4 hours of embryogenesis and at moderate levels between 4-12 hours
+Expressed early in the stationary phase
+Expression starts at 3 days after amputation in cells of the basal layer of the wound epithelium. At day 10, expression is found in both the basal wound epithelial cells and the distal mesenchyme cells. At mid-bud and late-bud blastema stages, wound epithelium expression has decreased, whereas the mesenchyme remains strongly active in transcription and showed a tendency toward distal regionalization. Condensing cartilage shows no signal. Finally, at the late digit stage, expression becomes largely restricted to the perichondrium
+Expressed during late pupal development and in adult females between days 1-3
+Elementary body
+Expressed in germ cells of L4 larvae (PubMed:33231880). Expressed at high levels in the pachytene stage of the meiotic region of L4 larvae (PubMed:33231880)
+Strongly up-regulated during root colonization, from the onset of syncytium formation by parasitic second-stage juveniles (pJ2) through the J3?J4 molts of sedentary life stages that become adult females
+Expressed in the embryo from 2 to 72 hours post-fertilization (hpf) (PubMed:22345307). Expressed in the embryonic heart and somites at 14, 20 and 24 hpf (PubMed:22345307). Expressed in myocardial progenitors from 18 to 24 hpf (PubMed:22345307). Expressed in the otic vesicle at 14 hpf (PubMed:22345307)
+Expressed during embryonic development
+Expressed at P5, solely within the inner nuclear layer (INL) of the central neuroretina. By days P6 and P7, expression expands peripherally during neurogenesis. By P12, expression is restricted to the outer margin of the INL and reaches the outer periphery of the neuroretina
+Expressed in larval muscles
+Expressed during development; especially from 4 hours of development and with a peak of expression at 12 hours of development
+May function as a drug tolerance determinant in biofilm, but not stationary phase planktonic cells
+Strongly expressed at day 7 followed by a disappearance and a gradual recovery to original levels by day 17
+At postnatal day 11 (P11) expressed in the soma and photoreceptor processes of the retinal inner segment, outer segment, outer plexiform layer, and inner plexiform layer. Expression in the inner plexiform layer is lost at P22
+Expressed in embryos, larvae and adults (PubMed:25232734). Broadly expressed in embryos (PubMed:28846083). Expressed broadly in neuronal and epithelial cells throughout the head during the dauer stage (PubMed:23932402)
+Expressed in developing and mature reproductive organs and during embryogenesis
+Expressed during the growth phase and early development. Expression starts to decrease strongly after tight aggregate formation
+Necessary only for stage 0 of sporulation
+Expressed in differentiating neurons in embryonic neocortex (at protein level)
+Expressed during pupal development and in adults
+Expressed from 15.5 dpc
+Highly expressed in small groups of cells undergoing tissue remodeling, such as ectodermal cells within indentations surrounding the eye and maxillo-nasal groove and in the first branchial pouch, lung buds, precartilagenous condensations, and mesenchyme of the limb. At 9.5 dpc, expressed only to head, prominent in the region of telencephalon and mesencephalon, and concentrated in cells along the dorsal midline. At 10.5 dpc, expression is moderated in the most rostral regions of the head, but particularly prominent in a lateral band of cells in the periocular region. At 11.5 dpc, detected in the telencephalon, frontonasal region and limbs. At 12.5 dpc, expressed in the telencephalon and hindbrain
+Expression in achenes and receptacles is ripening-related, with highest expression levels detected in fully ripe red receptacles
+Expressed in elongating and elongated spermatids (steps 9-16)
+At 11.5 dpc, expression is localized to the preplate and is absent from the ventricular zone which is the most prominent layer during early cortical development. At 13 dpc highly expressed in postmitotic, maturing neurons of the developing cortical plate and subplate. At 15 dpc expression is closely tied with the emergence of the neocortical layers and hippocampus. In the cortex, expression diminishes after birth, but continues in the deep layer pyramidal neurons and neuronal subpopulations of layer II/III. In the hippocampus, expression persists in CA1 pyramidal neurons and in the dentate gyrus. Postnatally, expression remains high in specific cortical neuron populations, particularly those of the deep cortical layers
+Detected at low levels during fetal development up to day 15. Highly expressed at day 17
+Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours
+In the CNS, it is expressed in the developing neural tube starting from 10.5 dpc in the spinal cord and around 11.5 dpc in the telencephalon. Expressed ubiquitously throughout the spinal cord and telencephalon during neurogenesis. Expressed throughout the developing retina at 15.5 dpc. Not expressed in the somite or presomite during somitogenesis. Expressed slightly later that Dtx2
+In the 8.5 dpc embryo, expressed throughout the embryo. Within a day, expression was more marked in mesenchyme than elsewhere (e.g. epithelial tissue, where it was generally low), although levels in neural tissue rose again by about 12.5 dpc. This difference was maintained until 15.5 dpc when expression levels started to drop in most tissues, with those of the nervous system, tooth, and kidney being exceptions. Strongly expressed in early mesenchyme. The expression decreased as the mesenchyme differentiated
+Expressed apically in the cortical neuroepithelium along the ventricular surface at 14.5 dpc
+During embryogenesis and crown root formation, it is expressed prior to the morphological differentiation of the root
+Expressed during the asexual blood stage (at protein level) (PubMed:32432369). Expressed in sporozoites (at protein level) (PubMed:32432369). Not expressed in host liver 48 hours post-infection (at protein level) (PubMed:32432369)
+Detectable throughout the second half of gestation
+In the mosquito vector, expressed at the ookinete stage
+Is detected in unfertilized eggs (at protein level) (PubMed:29424690, PubMed:31134275). Is also detected in late planulae, primary polyps and adults (both females and males) (at protein level) (PubMed:22048953, PubMed:29424690). Nv1 is transcribed throughout the complete life cycle and is found at multiple developmental stages including unfertilized eggs, blastulae, gastrulae, early planulae, planulae, metamorphosing planulae, primary polyps, juvenile polyps (2 and 4 months old), adult males, and adult females, with highest levels in juvenile polyps and adults (PubMed:18538344, PubMed:29424690). Importantly, Nv1 transcripts are not spliced in the embryo and planula due to intron retention and therefore Nv1 can be considered purely an adult toxin (PubMed:18538344)
+Expressed both maternally and zygotically. Expression is very low in the zygote, increasing from morula stage onward to reach a peak during early gastrulation. Levels then rapidly decline during neurula and organogenesis stages (at protein level). There is an inverse correlation between mRNA and protein levels at the late blastula and early gastrula stages
+Expressed in the embryo at 4 days after pollination (DAP) in the ventral and basal part of the embryo including the initial of the shoot apical meristem (SAM). At 5 DAP, expressed at the ventral side of the embryo, but the expression within SAM is down-regulated. At 7 DAP, expression is restricted to the boundaries between the embryonic organs, between the scutellum and the coleoptile, the coleoptile and the second leaf primordium, the shoot apical meristem and the first leaf primordium, the first leaf primordium and the coleoptile, the coleoptile and the epiblast and at the tip of the epiblast, but not in the leaf primordia
+Expressed both maternally and zygotically throughout development and in adult hermaphrodites (at protein level)
+Expressed in the neural plate border, Kupffer's vesicle, neural tube, otic vesicles, midbrain, eyes, forebrain and brain ventricular zone by 24 hours post-fertilization (hpf). From 36 to 96 hpf, expression is detected in the midbrain-hindbrain boundary, otic vesicles, pharyngeal arches, cranial cartilages such as Meckel's cartilages, palatoquadrates, and ceratohyals, cranial cavity, pectoral fin buds, brain ventricular zone, ciliary marginal zone, and digestive organs such as the intestine, liver and pancreas
+At 12.5 dpc, expressed in most tissues, especially in the nervous system, including the cerebral cortex, cerebellum, spinal cord and ganglion. There is no change in expression pattern from 12.5 dpc to neonatal day 1. Highly expressed in the subventricular zone and cortical plate of fetal brain and in the dorsal root ganglion of the peripheral nervous system. Except in the nervous system, expression in adult tissues is weaker than in fetal ones
+Expressed in 6.5 to 18.5 dpc embryos and transiently up-regulated from 11.5 to 13.5 dpc. In the developing brain, up-regulated 2 weeks postnatally, with gradual decrease thereafter. Still detectable at 52 weeks
+Increased transiently during flower induction
+Expressed throughout the cell cycle
+Prestalk specific
+Expression occurs in the 2 dpc embryo with increasing levels later in development. In the 9 dpc embryo highest levels are found in brain and spinal cord with intermediate levels in eye, heart, gut and muscle. Low levels are found in kidney, liver, skin and yolk sac
+Expression was detected in chondrocytes throughout the developing skeleton
+Expressed in the forespore, then exported into the developing cortex
+Detected during embryogenesis (at protein level) (PubMed:16139213). Maternally contributed, after which its levels fall slightly in embryo but increase again through development and in adult (PubMed:16139214, PubMed:16203113)
+Down-regulated during terminal differentiation of cells into spores and stalk
+First detected early in the generation of the clonal E cell lineage that is committed to intestinal development and then increases to maximal levels in actively differentiating intestinal and body wall muscle cells. Highest activity in embryos and falls dramatically during L1 larval development (PubMed:7781887). Expression is highest in L3 larval stage with low levels at other stages (PubMed:21884719)
+Transiently expressed during early embryogenesis
+At the time of ovulation
+From 7.0 dpc, expressed in muscle but also in brain and liver. Skeletal myogenesis is a major site of expression during normal embryogenesis. In addition, the ganglia of the developing peripheral nervous system and various embryonic epithelia, including those of kidney, lung and gut are also sites of expression. Declined slowly to adult
+Expression is decreased in adult compared to sexually immature individuals
+In skeletal muscle, strongly expressed in postnatal day 3 (P3), P7 and P15 muscles. Expression is not maintained in P21 in adult skeletal muscle (at protein level)
+In the neural tube, expressed as early as 9.5 dpc and expression is confined to the nervous system. By 12.5 dpc, can be found in the developing ventral horns and is also detected in the developing dorsal horns as well as in the dorsal root ganglion. Not detected in the ventricular zone, roof plate, floor plate or marginal zone (developing white matter). It is expressed from embryonic stage to adulthood
+Expressed in undifferentiated mouse F9 teratocarcinoma stem cells but disappearing rapidly after treatment with a tumor-promoting phorbol ester
+Ubiquitously expressed in embryos until eight hours after fertilization. Highly expressed in the developing neural plate eight hours after fertilization. Detected in telencephalon, retina, diencephalon, mesencephalon, cerebellum and rhombomeres between 24 and 38 hours after fertilization. Detected in tegmentum, myencephalon and notochord 48 hours after fertilization
+Expressed in developing brain, found in fetal newborn and adult brain
+Expressed zygotically
+Earliest expression is detected at 12.5 dpc in the developing brain in regions corresponding to the future rostral and caudal serotonergic neuron clusters
+Oocyte maturation is accompanied by the recruitment of specific maternal mRNAs into polysomes. G10 is an example of a protein which is translated at that time
+Expressed at embryonic stages 7 dpc, 11 dpc, 15 dpc and 17 dpc with a slight increase of levels during development
+Expressed at or just prior to spore coat formation, at 20 to 22 hours of development of the fruiting bodies. Secreted to the cell surface before cellulose is deposited
+Expressed in infective larvae (L3, L4) and adult stages
+Up-regulated during ripening
+Expressed in females at day 35 with higher levels detected at day 56. Not detected in males of any age
+First detected in torpedo stage embryos at the boundaries between the presumptive SAM and the cotyledons. Later expressed between the cotyledons and the meristem, and between the cotyledons. In seedlings, localized in stipules and at the boundaries between the SAM and the emerging primordia. Expressed at the site of lateral roots
+Detected in sporozoites
+Expressed throughout the cell cycle. Expression is highest in G0 and G1 phases and decreases during S and G2/M phases
+At 8.0 dpc expressed in prospective forebrain region. At 12.5 dpc, detected in the olfactory epithelium, septum, roof of the telencephalon, amygdala, prethalamus and hypothalamus. Expression was barely detected in the vomeronasal organs at 12.5 dpc. At 15.5 dpc, detected weakly in the olfactory epithelium, amygdala and hypothalamusat 15.5 dpc. Expression was not detected in the olfactory bulb or in the ganglionic eminences, where the interneuron progenitors of the olfactory bulb are generated
+Highly expressed in both pre-secretory and secretory differentiated ameloblasts in molars at postnatal day 1 (P1)
+Appears in increasing abundance on days 2 and 3 of the final metamorphic larval stadium and then declines to a very low level during day 4 prepupal stage
+Expressed in the G2/M phases
+Levels increase from 23 to 40 days after flowering, and are maintained until maturation (at protein level)
+Accumulates in oocytes before fertilization but fades out after fertilization
+Expressed at low levels during growth and development, with a peak during early aggregation (8 h). Mounds display weak expression within the upper regions and very strong expression at the perimeter of basal cells in contact with the substrate. Expression becomes tip-specific during first finger formation
+Activated during the early gastrula stage of embryogenesis. Expression is weak between stages 10 and 11 then increases sharply between stages 11 and 12, peaking at stage 13 and then sharply declining. Undetectable after stage 35
+Detected in larvae and expressed from the late pupal stage onwards. Highest levels of expression in adults
+Expression starts at 6.5 dpc (PubMed:9726247, PubMed:9510025). At 7.5 dpc, expressed over the entire embryo, with highest levels in the amnion. Up to 8.5 dpc, expression further increases and becomes more restricted to the foregut and the amnion. At 9.5 dpc, expression increases in the somites, as well as the developing gut, and is observed over the facial-cranial mesenchyme and the branchial arches. At 10.5 dpc, expression in the mesenchyme and the somites reaches its maximal intensity. At this stage, highest expression level is observed over the ventral part of the neural tube, in the marginal zone, and extends throughout the hindbrain. Also expressed in motor neurons of the spinal cord. With ongoing development, the brain becomes the main site of expression. At 11.5 dpc, expressed in the telencephalon, being restricted to the lateral aspects of the developing cerebral cortex, with highest levels in the outer layer of the neuronal tissue of the developing cerebral cortex. Also observed in the myelencephalon and in a thin cell layer in the rhombic lip of the metencephalon. At 12.5 dpc, expression begins in the mesencephalon and the diencephalon. Up to 14.5 dpc, expression levels in the developing cerebral cortex become more even and spread to more dorsal and caudal locations. At 14.5 dpc, decreased expression in the metencephalon and the myelencephalon. At 16.5 dpc, expressed over the entire cortical area, although at a slightly lower intensity. Expressed in the hypothalamus. At this stage, expression begins in the peripheral nervous system, including in the trigeminal ganglion, the dorsal root ganglia, the cochlear-vestibular ganglia and the sympathetic ganglia chain, but at lower levels compared to the central nervous system. Expressed over the mitral cell layer of the olfactory bulb and between the 2 outer walls of the gut. The overall expression levels in the cortex decrease until birth. At 18.5 dpc, the outer aspects of the cortical plate shows lower expression levels than the subventricular zone. At 18.5 dpc, expressed in the retina and the geniculate nucleus of the thalamus; this expression increases towards P0. At P0, expression levels are higher in the outer aspects of the cortical plate than in the subventricular zone (PubMed:9510025). 1 week after birth, abundantly expressed in the cerebrum, then levels decrease and become nearly undetectable at 4 weeks. Expression increases again and reaches moderate levels at 12 weeks. In the cerebellum, expressed at high levels during the first 2 weeks. Expression decreases at 4 and 8 weeks, and then increases again at 12 weeks (PubMed:9726247). Expressed in many organs outside the nervous system during organogenesis, such as the primitive gut where expression is detected already at 8.5 dpc. Other SORL1-expressing organs include the genital bud, the mesenchymal tissue, the developing skeletal muscles, the myocardium, the pituitary, the pineal, the thyroid and the Haderian glands, as well as the developing serous glands of the nasal cavity, the salivary and the submandibular glands, the pancreas, the epithelia of the stomach, the tubules of the kidney, the tooth germ, the cochlea, the nasal cavity, the trachea, the lung, the bladder and urethra, the intestine and the rectum (PubMed:9510025)
+Expressed in embryonic stem cells. Expressed in the pluripotent cells of the epiblast. Detected at the junction of non-neuronal and neuronal ectoderm just before neural tube closure. Expressed in the ventral epidermis before ventral closure, in the intermediate mesoderm, gonads and the forming nephric duct and tubules of the mesonephros and metanephros
+Detected in developing oocytes and early embryo. Detected in immature-germinal vesicle-stage oocytes, mature metaphase II arrested eggs and pronuclear zygotes, 2-cell, 4-cell and morula stages. Expression decreases in blastocyst stage
+Expressed in a variety of fetal tissues
+In the CNS, it is expressed in the developing neural tube starting from 10.5 dpc in the spinal cord and around 11.5 dpc in the telencephalon. Expressed ubiquitously throughout the spinal cord and telencephalon during neurogenesis. Expressed throughout the developing retina from 12.5 to 15.5 dpc. Expressed in the developing thymus. Not expressed in the somite or presomite during somitogenesis. Expressed slightly later that Dtx2
+First expressed in leaf primordia. Later confined to developing trichome cells where it persists at high levels throughout all stages of trichome development
+Present in silique vasculature and funiculi. In the anthers, restricted to the connective tissue at pre- and post-dehiscence stages and detected in the vascular tissue of the stamen filament
+Expressed maternally in the unfertilized egg and early embryo. In the embryo, expressed through cleavage stages (stage 2-8), becoming nearly undetectable following gastrulation (stage 10.5)
+Not expressed 1 day after seed imbibition but detected 4 days after imbibition and remains constant during seedling growth
+Expressed during late steps of pollen development
+First expressed at day 20 in post-meiotic germ cells. Levels increase until day 24 and then remain constant during maturity
+Expressed exclusively during oogenesis
+Expressed both maternally and zygotically. Expression is highest early in embryonic development (stage 5) and reduces to a low level during larval stages
+Expressed most highly in the liver, lung, and brain at posnatal day 2 (P2). In contrast, expressed most highly in skin at P8 in the epithelium surrounding the hair follicles
+Highest levels in younger leaves or stems segments and in older ones. Leaves and stems of intermediate age show a decreased expression. Appreciable amounts are also found in old root segments, and carpels
+Weakly expressed in embryonic gonads
+This protein is expressed in the cercaria but not in the sporocyst or adult worm
+PSBG are produced in high quantity during pregnancy
+Expression is seen as early as 6 hours of embryonic development and continues throughout embryonic and larval stages, increasing in abundance at each larval molt. The level remains high during pupal life but decreases to low levels in the adult
+Detected in hypothalamus, anterior pituitary gland and adrenals in fetuses at days 60-70, 100-110, 125-130. In newborn, levels increased significantly in the hypothalamus and pituitary gland but decreased to undetectable levels in the adrenal
+Accumulates during seed development in embryo cell types and in endosperm tissue
+Expression increases in fruit flesh during fruit development
+Expression begins at the late L1 larval stage
+At 10.5 dpc, expressed in the basal plate of the spinal cord, in the ventralneural epithelium of the developing brain and in the region of the lung bud. At 12.5 dpc, expressed in the complete neuroepithelium except for the neocortex. In the developing eye, expressed in the inner neuroblastic layer. At 14.5 dpc, detected in the intervertebral cartilage, the cortex of the developing kidney, the tongue, the region of the urethra and strongly in specific regions of the brain, e.g. striatum, optic recess, ventral tegmental area, roof of the midbrain, choroid plexus of the lateral ventricles and the fourth ventricle. The developing neocortex is devoid of expression. At this timepoint, expression is first notable in the inner ear in the developing maculae of the saccule and the utricle, in the cristae of the semicircular canals and in the vestibulocochlear ganglion. In the developing neural retina, a strong signal is present in the inner neuroblastic layer. At 16.5 dpc, expression is very similar to that at 14.5 dpc. At 18.5 dpc, expression is mainly as in 16.5 dpc. Expression in the ganglion layers of the retina decreases and is no longer detected in the innermost region of these layers. From postnatal day 7 (P7) onwards, also the developing photoreceptor cells express whirlin (PubMed:16434480). Expression decreases by 11 days after birth in inner ear hair cells and by 14 days after birth in outer ear hair cells. Expressed in vestibular hair cells at high levels through to adulthood
+Cell cycle regulated, peaking at the S phase. It is also expressed at high levels in exponentially growing cells in suspension cultures
+Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation
+Expressed in the embryo at 12 dpc (PubMed:8024701)
+Bcl-X(beta) is expressed in both embryonal and postnatal tissues, whereas Bcl-X(L) is predominantly found in postnatal tissues
+Expressed at a low level in neurula stage embryos
+Expressed during normal growth and slightly more for the first 4 hours of development. Enzymatic activity increases for the first 5 hours of development and then tapers off
+Expressed predominantly in the second larval stage
+Weakly expressed in neonatal testes and expression increases during the development of spermatocytes and spermatids, in the late meiotic and postmeiotic stages of spermatogenesis
+Is expressed in the early oocyte and is maintained at a constant level during embryogenesis. Its level declines at the mid-blastula transition
+Accumulates in imbibed seeds (PubMed:19704545). Detected in early stages of seed development, especially in the basal tip of immature embryo. Particularly expressed in vascular tissues of inflorescence stems, roots, leaves and petioles (PubMed:17410378)
+Seen during growth but not during development
+Detected from embryonic stage 12 onwards in midgut and Malpighian tubules (at protein level) (PubMed:22328496, PubMed:22854041, PubMed:26848177). Also detected in the outer epithelial layer of the proventriculus in first instar larvae (at protein level) (PubMed:22854041)
+Expressed from embryogenesis to adulthood
+Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed at different levels in embryo at 9.5, 10.5, 11.5, 12.5, 13.5 and 15.5 dpc
+During embryogenes is expressed most prominently in developing skeletal structures both in the craniofacial region and in the vertebral column
+Expression of isoform 2 is predominant at 18 dpc, but decreased during postnatal development paralleling increased expression of isoform 4 and isoform 5
+Detected in a few nuclei in the embryonic head as the embryo reaches morphogenesis stage. Expressed in an increasing number of nuclei as embryonic development progresses such that by the 1.5-fold stage it is detected in a large number of neuronal cells in the head and a few cells in the pharynx. At the 1.5-fold stage, expression is also prominent in motorneurons in the ventral cord and in neurons in tail ganglia. This expression is maintained during the 3-fold stage, but is reduced to undetectable levels in most cells before hatching. By the L1/L2 stage, expression is detected transiently in postembryonic motorneurons
+In parotid gland, weak expression detected at postnatal day P12, with levels increasing towards P16. In stomach, first detected at P16, with expression reaching adult levels during P20-24
+The proteoglycan form decreases from birth to adulthood in the cerebellum concomitant with non-proteoglycan form increase. In the cerebrum the maximum of expression of the proteoglycan is detected 15 days after birth and then decreases gradually to reach half-level at adulthood (at protein level)
+Expressed from birth
+Expressed in female gametocytes; however, translation is repressed by the DOZI complex and translation begins after fertilization with a peak expression at the zygote stage (PubMed:34119684, PubMed:35947628). Expressed in zygotes prior to apical protrusion formation (at protein level) (PubMed:35947628)
+Expressed at relatively high levels in vegetative cells. The expression goes down until the 8th hour of development and then goes up at 14 to 16 hours
+Mainly expressed during G1 and S phases
+Highly expressed in unfertilized eggs. Has low expression during embryogenesis. Expression then increases after hatching (48 hours post-fertilization), reaching maximum levels at 3 weeks of age
+Not expressed maternally. Zygotic expression from 24-72 hours post-fertilization (hpf). Also expressed in adult
+In embryonic fibroblast cultured in vitro, expression gradually decreases with passage number and totally disappears in senescent cells
+Expressed at 10 dpc, postnatal day P0, P13 and adult
+Expressed throughout the embryo at 3.5 dpc and 6.5 dpc. Higher expression is detected at 10.5 dpc nad then progressively decreases. Highly expressed in fetal hematopoietic tissues including liver, spleen and thymus. Expressed in the endothelium lining the dorsal aorta of 11.5 dpc embryos (at protein level)
+Gradually accumulates upon germination
+Expressed between 3 and 22 days post anthesis (DPA), with a peak between 11 and 15 DPA
+Initially localized to segmentally repeated clusters of mesodermal cells, and subsequently in at least a subset of growing muscle precursors and mature muscle fibers that exhibit distinct segmental differences
+Detected before the 1k-cell stage, suggesting that it is maternally supplied. At the sphere stage, stronger expression in the dorsal blastomeres. In the gastrula, expressed in the whole embryo, except in the evacuation zone. During segmentation and pharyngula period, expressed in many distinct domains, including the polster, telencephalon, trigeminal placodes, rhombomeres, trunk neurons, somites and axial vasculature. During the pharyngula period, additional expression observed in lateral line primordia and in intersegmental vessels
+During embryo development, expressed from the heart stage onwards and restricted to the adaxial side of the cotyledons in mature embryos
+In developing flowers, observed in sepals, anther filaments, ovaries and meristem tissues. Also expressed in root meristem tissues and in areas of lateral root formation. In leaves, detected in guard cells and trichomes
+Expressed weakly in 16-24 hours embryos and second instar larvae and strongly in first and third instar larvae and adults
+Between 11.5 dpc and 12.5 dpc it is specifically expressed in the developing heart. From 13.5 dpc, expression in the heart disappears, while it becomes strongly expressed in the brain. Up-regulated during adhesion and differentiation to beating cardiomyocytes
+Detected in the mature and germinating pollen grains
+Detected only in garland nephrocytes at the embryonic stage. Highly expressed in both garland and pericardial nephrocytes at the larval stage
+Levels peak 3-4 days after germination. Expressed following temporally and spatially discrete patterns of gene expression in lateral root cap cells, vascular tissue of roots, developing leaves, the hypocotyl, and in the style/stigmatal tissue (PubMed:9681017). Expressed at the early stages of vascular tissue differentiation in roots; strong accumulation in the protoxylem at the transition, elongation, and maturation zones (PubMed:25883242). Accumulates in developing tracheary elements before lignification. Present in cells destined to undergo programmed cell death (PCD) in both vascular tissue and the root cap. In flowers, restricted spatial and temporal distribution; at stage 11-13, after papillae formation, accumulates in tracheary elements of style and stigmate (PubMed:9681017)
+Maternally expressed. Ubiquitously expressed in embryos at 1 day post-fertilization (dpf), with a more discrete accumulation in the embryonic kidneys. In developing kidney, expressed in the midsections of the pronephric ducts, in a pattern consistent with the multiciliated cells
+Expression varied mildly across the cell cycle, with highest expression observed in G1 and stationary-phase cells
+In brain cortex, expressed in postmitotic excitatory neurons at 14.5-16.5 dpc
+Abundantly expressed in amastigotes and trypomastigotes. In epimastigotes, KMP-11 is expressed at a high level during the logarithmic growth phase but is down-regulated during the stationary phase of growth
+Expressed in epithelia cells during gastrulation (at protein level). Expressed in oocyte, cleavage, gastrulation, and neurulation stage embryos. Expression decreases by the end of gastrulation at stage 12. Weakly expressed during neurula at stage 16. Strongly expressed at stage 31 and remains at a robust level through early tadpole stages. Expressed in heart, somites, cement gland and eyes at stage 35. Expressed in the embryonic heart from stage 31 through 41 in the outer curvature of the ventricle and atrial regions
+Expressed throughout all stages of development. Expressed at higher level in adult females
+Expressed in early stages of embryonic development
+Expressed throughout pollen development
+Present in inflorescence meristem and later in young floral mersitems. Expressed in sepal, petal, stamen and carpel primordia. In petal, progressively confined to petal margin and epidermal cells. Restricted to sporogenous tissue in the stamen and to the medial ridge of the carpel. Present in tissues that develop from this ridge, such as placenta and ovule primordia. In ovules, first expressed in distal part of the funiculus and the outer integument, before being confined to the funiculus
+Only present in B-cells and in A/B diploid cells
+Expressed during flower development until 15 days after flowering
+First detected at postnatal day 20 and 40 in testis and epididymis respectively
+Maternally transcribed. During neurogenesis, expression is reactivated in neuroblasts and ganglion mother cells, and disappears as neurons differentiate
+Highly expressed in pachytene spermatocytes (at protein level) (PubMed:26268560)
+Specifically expressed in germ cells of the developing testis, starting from 12.5 dpc. The protein is detected as early as 13.5 dpc in embryonic testes, but expression declines around the perinatal period and then is restored at around 2 weeks after birth. Also detected in the embryonic ovary at a low level. In adult testis, mainly present in the spermatocytes from the pachytene stage onward (at protein level)
+Expressed in cells along the anteroposterior axis from the 1.5-fold stage of embryogenesis until the 3-fold stage when expression decreases but increases in the body surface with prominent expression in the lateral hypodermal cells (PubMed:23028364, PubMed:15454573). Expressed in the pharynx and body wall from the larval stage to adulthood
+Expressed both in gametocytes and in liver-infective sporozoites
+During spermatogenesis, expression is low in the round spermatids of stages I-II before increasing to peak in the elongating spermatids of stages III-VII. Decreased expression observed in stage VIII
+Increases rapidly between 1 and 4 days after seed germination (PubMed:16813579). In roots, accumulates transiently during flower buds initiation (PubMed:29872026). In leaves, mainly observed after budding (PubMed:29872026). High levels in stems and capsules (walls and content), especially after flowering (PubMed:29872026)
+In embryos and larvae, detected mainly in nerve cells in the preoptic-hypothalamic regions and fibers innervating several brain regions (at protein level) (PubMed:22522977, PubMed:27315774). In embryos, detected in the anterior commissure, postoptic commissure, hypothalamus, pituitary gland, ventral hindbrain and the white matter of the ventral spinal cord (at protein level) (PubMed:27315774, PubMed:30903017). In larvae, detected in brain regions including telencephalon, hypothalamus, mesencephalon, medulla oblongata and pituitary at 30 hpf onwards (at protein level) (PubMed:22522977). Both isoforms are maternally expressed and detected throughout embryonic development (PubMed:22522977). Low-level expression detected throughout the developing embryo at 6-24 hours post-fertilization (hpf) with more focused expression detected in specific groups of neurons in the brain at 28 hpf onwards (PubMed:22522977)
+Accumulates during oogenesis and remains stable as a maternal product throughout early development
+Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed at a high level in the distal airway epithelium and at a low level in the proximal airway epithelium at 12.5 dpc, and restricted to the distal airway epithelium by 14.5 dpc. In the spinal cord, at 12.5 dpc, expressed in a subset of interneurons dorsal to motor neurons. At 16.5 dpc, expression in the brain is observed in the inner intermediate zone of the neopallial cortex and in the developing cerebral hemispheres. In the gastrointestinal system, at 12.5 expressed in the outer mesodermal layer and in the intestinal epithelium. By 16.5 dpc, expression is restricted to the outer longitudinal muscle layer of the intestine and stomach. In the cardiovascular system, at 14.5 dpc, expressed in the outflow tract region of the developing heart. By 16.5 dpc, observed in the outflow tract and atrium, but not in the ventricles
+Expressed at low levels in the embryo but at high levels in the labyrinthine trophoblast cells of the placenta
+Expressed during testis cord formation in pre-Sertoli cells, at a time immediately after the peak of SRY expression
+Highly expressed 2 days after pollination and then rapidly decreases to basal level
+Maximal activity in trypomastigotes, minimum in epimastigotes and not detectable in amastigotes
+Highest abundance during larval stage (prior to the secretion of pupal cuticle) and adult stage
+Expressed from late blastula/early gastrula stage throughout embryogenesis
+During embryo development, expression increases from 15-21 days after pollination and decreases slightly at day 24 and this level is maintained until day 36
+Expressed in the sciatic nerves at postnatal days P6 to P12
+During late gestation, it is expressed in lung epithelial cells, whereas perinatal expression is restricted to the bronchiolar epithelium
+Expressed in NK cells from the thymus at 15 dpc (at protein level)
+Expressed in the intermediate and late stages of T-cell differentiation
+Expressed in cells of the male tail tip from the L3 larval stage. Expression peaks during male tail tip retraction and decreases rapidly upon completion (PubMed:18550714). Not expressed in cells of the hermaphrodite tail tip at any developmental stage (PubMed:18550714)
+The appearance of the MF1 antigen correspond with the onset of the parasite's ability to infect the mosquito
+During germline proliferation
+In embryos, expressed in leading edge (LE) cells (at protein level) (PubMed:20530545). In larvae, expressed in the wing imaginal disk cells in the future hinge region, specifically in the peripodial stalk and in the peripodial membrane cells (at protein level) (PubMed:15342518, PubMed:25737837). In larvae, expressed in the A8 abdomen-derived cells in the male genital disk (at protein level) (PubMed:20530545). In third instar larvae, expressed in the anterior and posterios termini (at protein level) (PubMed:15342518). In adult fly, expressed in the wing hinge, in the socket cells of the micro- and macrochaete and proboscis (at protein level) (PubMed:15342518). In embryos, expressed in leading edge (LE) cells during germ-band retraction and dorsal closure from stage 13; expressed in some cells of the amnioserosa in particular in the posterior canthus as well as in the ventral ectoderm; expressed both in head and tail region (PubMed:20379222, PubMed:20530545, PubMed:28628612)
+Detected as early as postnatal day 15 (P15), and then continually increased during the first 45 days
+Found initially in all cells of the cleaving embryo, but gradually becomes restricted to oral ectoderm and endoderm cells
+Expressed at the early stages of sporulation
+First expressed after puberty
+Expressed during larval development
+Expressed during the early stages of root primordium development and disappears prior to the emergence of lateral roots from the parent root
+Expressed throughout embryogenesis. Expression in the colon and small intestine is highest in newborns and declines with age. Expression in the kidney increases with age
+Predominantly expressed in early stage germ cells, type-B spermatogonia and early spermatocytes
+Expressed both maternally and zygotically in the embryo, expression seen in all developmental stages
+Expressed during the asexual blood stage, including rings, trophozoites, schizonts (at protein level) (PubMed:22355110, PubMed:29241041). Expressed in male and female gametocytes (at protein level) (PubMed:22355110)
+Expressed in the mother cell during sporulation
+Detected at low levels in newborn brain. Levels increase steadily during postnatal development up to adulthood
+Expression is detected in the brain from embryonic day 12 and continues into adulthood
+Widely expressed at 9.5 dpc, including high levels in the neural tube, somites, the posterior region of the midbrain, olfactory placode and the branchial arches. At 10.5 dpc, reduction of the widespread expression and stronger expression in the neural tube, branchial arches, developing limbs, telencephalon, nasal process, lense vesicle, anterior and posterior regions of the mid- and hindbrain. From 11.5 dpc on, strongly expressed in the genital tubercle and hair and vibrissae follicles. From 12.5 dpc onwards, expression decreases, with a complete lack of expression in the cephalic region and the neural tube at 14.5 dpc. Strongly expressed during limb development, with higher levels in hindlimbs compared to forelimbs and expression slightly more marked in the posterior region of the limb buds. At 11.5 and 12.5 dpc, detected at the distal domain and the underlying mesenchyme, but not in the apical ectodermal ridge. Distally, becomes confined to the digits at 13.5 and 14.5 dpc
+At 7.5 dpc, expressed in the pit cells of the node, which carry motile cilia and are involved in left-right axis development
+Expressed in flower buds at development stage 2 in archesporial cells, in primary sporogenous cells and primary parietal cells at stage 3, and in secondary parietal cells at early stage 4. In microsporocytes, expression increases at stage 5 and at late stage 5, expressed predominantly in both tapetum and microsporocytes. Expression in tapetum and microsporocytes is reduced greatly at stage 6 and then declined gradually to be not detectable at stage 10
+During embryonic development, expressed preferentially in epiblastic cells and germ cells. In pre-streak embryos, detected in the whole epiblast, but not in the forming hypoblast (stages XI through XIII) (at protein level). As the primitive streak starts to form, disappears from the primitive streak epiblast, but still expressed throughout the area pellucida epiblast (stage XIV -> 3+). At the end of gastrulation (stage 4+), quickly decreases in the epiblast and persists in a crescent anterior to the emerging head process (stages 4+ through 6). At stage 5, strongly expressed in some of the cells in the germinal crescent, probably corresponding primordial germ cells. At stage 7 (neurula stage), undetectable in differentiated cells (at protein level). As the neural plate forms (stages 6-8), expression in the epiblast is restricted to the anterior neural plate. At stage 33, still expressed in germ cells. At stages 42-43, expressed in gonads, as well as in brain, kidney and heart, but at much lower levels than in proliferating embryonic stem cells
+Expressed in the hypodermis, intestine, body-wall muscle cells and pharyngeal muscles pm3, pm4, pm5, pm6, pm7 and pm8 in all larval stages as well as in adults
+During the development of the testis, expressed 2 days postpartum (dpp) and then starts to increase at 14 dpp when pachytene spermatocytes first appear
+Expression increases with age
+Expressed during early cleavage, gastrulation and at 1 day post-fertilization
+Isoform 2 is predominantly expressed in adult stage. Isoform 3 is up-regulated during postnatal development
+Expression commences during embryonic germ band elongation and persists throughout development and in the adult. Highest level of expression observed in late embryonic, late larval and early pupal stages
+Expressed from 172 minutes after the first cleavage, in the ABalaappa cell and continuing in its daughters, and in the cholinergic motor neuron M4 from mid-embryogenesis through to adult stages
+Accumulates steadily during G2 and is abruptly destroyed at mitosis. Not detected during the G1 phase of the cell cycle. It accumulates during the DNA synthesis/S phase and disappears as cells progress into mitosis, between prophase and metaphase (at protein level)
+Progressively accumulates during culmination, especially at the onset of the stalk formation. Present in fruiting body (at protein level)
+Accumulates during fruit maturation and ripening
+Expressed throughout postnatal development of the brain and present at high levels in the adult
+Expressed from threefold embryo stage, in the nervous system and intestine, and persists through adulthood (PubMed:18434533). Expressed in head neurons of embryos and adults (PubMed:18434533)
+Maternal transcripts are distributed throughout animal half of the embryo during cleavage stages. At the late gastrula stage, maternal transcripts decrease and zygotic transcripts appear specifically in the ventral region of the embryo. After neurulation, expressed ventrally in the closed blastopore slit and the neural tube. At the tailbud stage, detected in the postanal region, heart and dorsal eye
+Expressed at the 2-fold stage embryo
+HGI-III is expressed before germination. HGGI-I, HGGI-II and HGGI-III are expressed after germination
+Expressed during all stages of embryonic development, from 1-cell to 72 hours post-fertilization (hpf) (PubMed:23071114). Expressed in the forebrain, the midbrain, the mid-hindbrain boundary and eye area at 24 hpf (PubMed:23071114)
+Detected in testis from postnatal day 16 onwards, reaching maximal levels by postnatal day 18
+Specifically expressed in cells committed to the neuronal lineage (at protein level). Weakly expressed at 7 dpc, expression strongly increases at later embryonic stages. Expressed abundantly in almost all neural tissues at 12.5 dpc and also detected in tongue muscles, genital tubercle and hand plate. At 15.5 dpc a strong expression in skeletal muscles is detected together with the strong expression in neural tissues
+Highly expressed in the embryo and the surrounding maternal tissues, the pericarp and the integuments. Also found in the germinating grain
+Expressed at all stages of development
+Expressed in L1 larval stage and in adults (at protein level) (PubMed:16236031). Isoform a: Expressed in L1 larval stage and in adults (at protein level) (PubMed:16236031)
+Expressed in the region posterior to the Hensen node at stage 6. Detected in the dorsal domain of the neural tube and the CNS of the developing embryo. In the developing limb, expression starts at stage 18 in the posterior-dorsal region of the distal mesenchyme, and gradually expands to the anterior-distal region. Also found in the feather bud and branchial arch
+Expressed in the embryo proper during early embryogenesis and in the developing vasculature in later stages (PubMed:16763149). Expressed dinamically in the proximal region and in the nucellus during ovule development and mainly observed in the nucellus in mature ovules (PubMed:25378179)
+Expressed in the asexual intraerythrocytic stages
+In addition to the main band of expression at the midbrain-hindbrain boundary, the protein is expressed in the mandibular arch, the optic tectum and the region of anterior pituitary
+The expression is restricted to the gonads during the sex determination period and throughout embryogenesis. In developing testis, the expression is found only in the Sertoli cells. The expression is strongest at day 11.5, more intense in the testis than the ovary. From 12.5 dpc the expression in the ovary is reduced and disappears. The expression at day 13.5 dpc is restricted to the testis cords
+Abundant in full grown oocyte and the ovulated unfertilized egg, shows a slight decrease 12 hours after fertilization. Transcripts from the activated embryonic genome are present in the eight-cell embryo
+Expressed in the proliferating cells of the coelomic epithelium of male and female gonads at 12 dpc. In female, expressed in the whole gonadal primordium at 13.5 dpc; in the surface epithelium and in the ovigerous cords at 15.5 dpc. In male, expressed at surface cells of the gonads at 13.5 dpc; in mesenchymal cells outside testicular cords at 18.5 dpc
+Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and pancreas (PubMed:10873595)
+Highly expressed in the capillary loop stage and very faintly in the S-shaped body stage of glomerulus in fetal kidney of 16 weeks of gestation
+Transcribed predominantly during S phase, translated exclusively during mitosis and cytokinesis and rapidly degraded after cell division
+Detected in axillary mersitems which appears in the axils of leaves after flowering. During bud vegetative development, down-regulated in the outer layers of the meristem, but accumulates transiently in young leaf primordia. In buds bearing flowers, restricted to the provascular tissue underlying the bud. Accumulates in axillary buds, but disappears at the time of bud outgrowth
+Expression is transiently increased during brown adipocyte differentiation
+Expressed maternally and throughout development. Expressed in the animal hemisphere of eggs and cleavage stage embryos. Expressed in the ectodermal region of blastula and gastrula stage embryos and in the anterior and dorsal regions of neurula stage embryos. Expressed in the brain, ear, eye, branchial arches and spinal cord of tailbud stage embryos
+Maternally derived transcript is detected at high levels in blastula. Detected at intermediate levels in the head region, the rhombencephalon, otic vesicle, mesencephalon, optic vesicle and in the anterior parts of the spinal cord in late neurula stages
+Expressed in the condensing dorsal root ganglia at embryonal day 3, and in the primary sympathetic chain ganglia at embryonal day 4
+In embryo expressed at 11 dpc, 15 dpc and 17 dpc
+Expressed specifically in the apical domains of the shoot apical meristem (SAM), inflorescences, ovules, anthers and embryos. In young seedlings, localized mainly in the outermost three to four cell layers of the main shoot apex and in developing leaf primordia and young leaves. Also present in the meristem zone of primary roots and in the initiation site of lateral roots
+Expressed from 16 cell embryo stage, long before shoot meristem is evident, and gradually become restricted to the center of shoot meristem primordium
+Increases rapidly between 1 and 4 days after seed germination
+More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs
+Expressed at the blood stage in schizonts (at protein level)
+Expressed from day 10 in the embryo. Low levels found between days 10-12. Expression peaks on day 13 with moderate levels from then until birth
+Expressed in chondrocytes throughout the developing skeleton in a pattern very similar but not identical to those of type II and IX collagen. In the newborn mouse skeleton it is expressed essentially in a mutually exclusive manner with tenascin, which is expressed osteoblasts, periosteal and perichondrial cells, and in cells at articular surfaces
+Highly expressed during vegetative stage. Expression decreases during development and is very low from 12 hours (late aggregation stage)
+First detected at 10 hpf (1-somite stage), with increased levels during subsequent embryonic development. Also expressed in adult
+Expressed primarily in adult rabbits
+Expressed at each stage of development with predominance of isoform c in early larvae and isoform a in adults
+Expression is induced during osteoclastogenesis
+Throughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas
+Expressed in touch receptors from late embryos to adults
+Expressed at the comma stage in endodermal precursor and hypodermal cells of the embryo. Expressed in the hypodermis and gut during elongation and larval stages. Expressed in neuronal precursor cells at the comma stage. Expressed in neuronal cells in the head and tail, in cells of the ventral nerve cord and of the pharynx at the L1 hatched larvae stage
+At postnatal day 1, not detectable in any brain area examined but at postnatal day 8, strongly expressed in both astrocytes and oligodendrocyte precursors (OPs). At postnatal day 15 and during adulthood, expression in astrocytes and OPs remains at high levels
+Expressed both maternally and zygotically. Transcripts localizes to the Balbiani body during oogenesis (PubMed:18582455)
+Starts to be expressed in seedlings from 2 days ays after germination
+Expression is constant throughout the development
+Detected in embryonic chondrocytes in humerus and ulna during embryonic bone development. Not detected in mature bone
+Expressed until four or five weeks after birth. Detected at very low levels in adults, where it constitutes about 1% of the total hemoglobin. In contrast, the levels of fetal hemoglobin F (two alpha chains and two gamma chains) are increased in children and adults with beta-thalassemia or sickle-cell disease. In cases of homozygous alpha-thalassemia, homotetrameric hemoglobin Bart's is highly expressed and is the predominant form of hemoglobin after 10 weeks of gestation. Its levels increase steadily after 10 weeks of gestation and until birth (at protein level)
+Expressed both maternally and zygotically. Expressed at a low level in the unfertilized egg. Expression is highest at the gastrula stage, then declines before rising again during the tadpole stage
+Expressed in developing caryopses from 3 days after flowering (DAF), increases to a maximal level at 5 to 7 DAF, and then gradually declines to a barely detectable level by 20 DAF when grain filling stage nearly terminates. Expressed in developing pollen and anther walls from 5 to 1 day before anthesis
+Low protein levels at birth that increase progressively at least until 14 days after birth
+Ubiquitous in embryonic tissues, but expression is acutely down-regulated after birth, except in the brain, to a level that is maintained throughout adulthood
+In flowers, expressed in the sepals and the style. In siliques, present in the tip and the base, in funiculus and in mature seeds. Present in both dried and imbibed seeds, especially in the seed coat and micropyle
+Expressed in the proliferating cells of the developing CNS and the epidermis. In the spinal cord at embryonic days 10.5, 11.5 and 12.5 dpc, expressed in the proliferating cells of the ventricular zone of the neural tube and is expressed at reduced levels in the intermediate zone. At 14.5 dpc, found in regions containing differentiating post-mitotic neurons. In the developing epidermis at 17 dpc, expression is restricted to primary hair germ cells only
+Abundantly expressed at embryonic day 7 with lower levels at embryonic days 11, 13 and 15
+Maternally expressed. Expressed primarily in the central cell of gametophyte before fertilization. Not expressed in endosperm and embryo after fertilization
+Early detected in the floral meristem and floral organ primordia. At later stages, expressed in all floral organs and in particular in the ovule
+Increases during pregnancy (1.6-fold at 4 days) and lactation (3.8-fold at 7 days). Decreases in the early phases of involution (45%, 50% and 34% on days 1, 2, and 3 respectively)
+Accumulates in a sporulation-specific manner during the uredinial stage of the life cycle
+Levels increase during the first 3 weeks after birth and remain high in the fourth week
+Expressed in heart at embryonic day 14 (at protein level). Expressed in heart at embryonic day 8
+Expressed in round hematopoietic cells in yolk sac blood islands at 8.5 dpc. Expressed uniformly at 10.5 dpc. Expressed in the brain, spinal cord, neuroepithelium and in spinal ganglia at 12.5 dpc. Expressed in brain, spinal cord, developing epithelia of the lung, stomach, intestine, outer region of the developing kidney, liver, brown fat tissue, skeletal muscle, developing craniofacial region, thymus, cochlear and pharyngeal epithelia and olfactory and respiratory epithelia at 16.5 dpc
+Expressed in testes and ovaries
+Detected prior to 7.5 dpc, with peak levels at around 11.5 dpc. In the developing limbs and face, levels are highest at 13.5 dpc and decline dramatically thereafter
+First synthesized at embryonic day 5, it remains expressed by cultured Schwann cells
+Expressed in late S and M phase of the cell cycle. Degraded in G1 by the APC/C in its CDH1-bound form
+Highly expressed in embryos (at protein level) (PubMed:19167330, PubMed:22238360). Expression decreases rapidly in larvae and becomes restricted to the germline in adults (PubMed:19167330)
+Peak of expression in seeds 15 days after flowering. Highly expressed in senescing leaves
+Expression is low in day 7 embryos, peaks at day 11 and declines through to day 17
+In pregnancy, the expression of NKB is confined to the outer syncytiotrophoblast of the placenta, significant concentrations of NKB can be detected in plasma as early as week 9, and plasma concentrations of NKB are grossly elevated in pregnancy-induced hypertension and pre-eclampsia
+Expression of this protein in embryos and limbs is associated with areas undergoing movements, morphogenetic rearrangements, or rapid cell division. Expression of annulin precedes the first morphological signs of segmentation in the developing limbs
+During flower development, detected in sepals, anther filaments, and carpels. During germination, levels decline slightly two days after imbibition
+Expressed at a low level in mature polyps and planula larvae, and at a high level in primary polyps
+Expression begins at stage 10.25. Levels increase throughout gastrulation before reaching a peak between stages 11.5 and 12
+Expressed from 6 dpc in brain
+Expression begins at the 1.5-fold embryonic stage and is retained in the adult
+Expressed during the asexual blood stage, specifically during the trophozoite, schizont and merozoite stages (at protein level)
+Biphasic expression pattern observed. Gradual increase in expression during development from embryo through to adult with a decrease during larva stages 1 and 2
+Both isoforms are expressed at higher levels in bradyzoites than in tachyzoites. Isoform MyoC is the predominant isoform in tachyzoites
+Isoform B expressed maternally and zygotically. Isoform B expressed throughout development, in larvae, in pupae and in adult flies
+Expressed in late embryogenesis and in the involuting postpartum uterus
+Expressed throughout development. Localizes to the posterior pole of the oocyte during stages 1-9 of oogenesis
+Found in chondrogenic regions in the branchial arches, somites and limb buds at 22 dpc. At 28 dpc detected in the limbs, developing scapula, prevertebrae and ribs. Found in condensing mesenchyme of the forelimb at 25 dpc. Expressed in the condensing mesenchyme at the distal tips of the developing hindlimbs at 26 dpc
+Expressed specifically in bloodstream forms
+Highly expressed during the first days following germination and then decreases with time
+Highly expressed in neurons during their differentiation
+Only detected at and after 15 days after pollination and remains at moderate level
+Detected at 0-3 hours post-fertilization (hpf), probably due to inheritance of maternal transcripts. Expression then declines, and increases again from 12 hpf onwards. Detected in the developing hypothalamus from 24 hpf. At 3 days post-fertilization (dpf), found in two subsets of neurons in the lateral hypothalamus
+Increased expression in developing cotyledons between days 5 and 7 but thereafter relatively constant
+In testis, expressed at all stages from the late pachytene primary spermatocyte to the secondary spermatocyte. Not detected at day 7 after birth. Expression is detected at day 14 and increases dramatically at day 21 and reach a peak at day 28 to remain high until day 56
+Expression increases dramatically during development and oncogenesis
+In myogenic progenitor cells, expressed during the acquisition of muscle stem cell properties, from 18.5 dpc to adulthood
+Expressed only in spinal cord at 13 dpc. At 18 dpc and P0, appears weakly in forebrain. Expression in brain increases after birth and peaks at P10
+Circulating plasma levels decrease with age while levels in skeletal muscle increase with age (at protein level)
+Expressed from embryos to adults. Expressed in embryos from the two-fold stage, and is ubiquitously expressed during embryonic and larval stages of development
+Expressed throughout embryonic, larval and adult stages (PubMed:15099742, PubMed:19064914). Highly expressed at the L3 larval stage at 25 degrees Celsius (PubMed:29055282)
+Expressed ubiquitously at 24 hpf
+Expressed in the CNS, tailbud and somites
+Expressed in the early stages of lateral root primordia formation (PubMed:17630277). Expressed in early floral meristem (stage 1 to 2) (PubMed:19482972)
+Expressed throughout embryonic development
+Isoform 1 is expressed during the segmentation period and is initially detected at the 7-8 somite stage; Isoform 2 is expressed at all developmental stages and appears in the first somites
+Expressed both maternally and zygotically from embryos to adults. High expression is seen in embryos, pupae and adults (highest in early pupae) and low expression in larvae
+First expressed postnatally between days 19 and 22 coinciding with the early stages of spermiogenesis. The levels increase up to postnatal day 60
+In glial cells around the mushroom body dorsal lobe, expression is weak in wandering larvae and pupae at 12 hours after puparium formation (APF) and is elevated in pupae at 6 hours APF (PubMed:16772168). In naive stage 11 macrophages, expressed at low levels with increased levels seen following apoptotic cell corpse uptake and a further increase observed by stage 15 (PubMed:27212238). Isoform A: Selectively expressed in adults (PubMed:22426252)
+Expressed in late embryos (PubMed:12921736). At the L1 larval stage and during the dauer stages, it is expressed adjacent to the lateral edges of the alae (at protein level) (PubMed:12921736). In the L2 pre-dauer stage, expressed in the head hypodermal cells hyp3, hyp4, hyp5, hyp6 and hyp7, along the main body and in tail hyp8, hyp9, hyp10 and hyp11 (PubMed:12921736). Not expressed at adult stages (at protein level) (PubMed:12921736)
+Expression is developmentally regulated in muscle and is associated with neuromuscular junctions during the late embryonic period
+Expressed in the ectoderm at early gastrula stages. During neurulation, expressed in the dorsal neuroectoderm, with the strongest signal detectable in the anterior neural plate. In tadpole stages, present most prominently in the brain, eye, otic vesicle, and cranial ganglia. From stage 30 onward, expression is observed in the forebrain, midbrain, and hindbrain but is excluded from the boundaries between these domains
+Expressed in embryo, larva, pupa and adult
+Expressed both maternally and zygotically. Strongly expressed in embryo and pupa. Weakly expressed in larva. Mildly expressed in adult
+Expressed in the embryonic brain and in the ciliated cells of the otic and lateral line placodes. Also expressed in precursors of the epidermal ciliated cells. Expressed early in the anterior neural plate starts early
+Expressed in developing craniofacial tissues, intestine and lens
+After the very early developmental stages, the expression levels decrease and remain relatively constant until around 24 h, with the onset of an increase of expression that continues till the larval stages
+Expression was detected in fetal liver neuronal and bone tissues (12.5 dpc and 15.5 dpc). High expression was detected in thymus and gut at 18.5 dpc and continued postnatally. Expression in bone (mandible and vertebrae) and brain tissues (cerebellum, hippocampus and cortex) remained high after birth. In addition high expression was detected in kidney, spleen and skin at P5 and P10
+At 10.5 dpc, widely expressed with more intense expression in the maxillary prominence, branchial arches, limb buds, somites and spinal cord
+Expressed in the ventricular zone of the brain at 28 hours post fertilization (hpf) and, at lower levels, in the posterior cardinal vein and in the posterior intermediate inner cell mass. At 48 hpf, still detected in the vein. At 28 and 48 hpf, expressed at low levels in a region near the dorsal aorta
+Expression was first detected at postnatal day 6, and reached the adult level between postnatal day 14 and 21
+Expressed in the 1-cell embryos (at protein level) (PubMed:20599902). Expressed during gastrulation and throughout the larval stage and in adults (PubMed:12930831)
+Found at 10.5 dpc through 16.5 dpc
+Expressed abundantly in logarithmic phase promastigotes, and to a lesser extent in stationary phase promastigotes and amastigotes
+From 12.5 dpc to 18.5 dpc, expressed in the developing neural tissues, including several discrete regions in the forebrain, midbrain and hindbrain, as well as in the spinal cord. May be up-regulated in the course of preosteblast differentiation and matrix mineralization
+Expressed in uterus at 12.5 dpc (at protein level)
+Expressed from 4 hours and peaks at 9 hours after onset of sporulation
+Expressed during spermatogenesis and at later stages of oogenesis. During embryonic and larval development, expressed ubiquitously. Starting at stage 10 embryos and lasting until the end of embryonic development, strongly expressed in the salivary glands and in cells of the presumptive proventriculus. Maternal expression abundant in early embryos. Zygotic expression commences in the epidermis and salivary glands from stage 11, initiates in the trachea at stage 13, and at early stage 15 is also detected in the foregut and hindgut tubes
+Expressed exclusively in the inner root sheath (IRS) of anagen hair follicles, where expression is predominantly in the hair cone during anagen III and in the Huxley and Henle layers of the inner root sheath during anagen VI
+Uniformly expressed at blastoderm stage. Weakly but broadly expressed at later stages of embryogenesis
+Expressed in mitotic and meitotic cells. In meiotic nuclei, first detected at interphase, and binds to the chromosome axis from early leptotene through to anaphase I
+Accumulates during aging. Expressed in leaves and roots of young seedlings and in leaves, roots, and inflorescences of mature flowering plants. In leaves, present in the phloem, in developing xylem elements, epidermal cells, and neighboring mesophyll cell layers. In flowers, localized in pistils, ovules, and receptacles
+Detected both in virgin rats and after mammary gland involution. The level of STAT5A increases constantly during pregnancy, but decreases at the onset of lactation and remains lows throughout lactation
+Expression is restricted to the hematopoietic compartment of development
+Expressed in embryos at various developmental stages. The expression is found to be higher between 11 and 15 days of gestation compared to day 7 or 17
+Larvae
+Expressed in both the early and late embryonic stages of development
+Expressed both maternally and zygotically (PubMed:7935398, PubMed:9012532, PubMed:1712294, PubMed:17246162, PubMed:28059165). Isoform B: Expressed in the notum from early pupation to 36 h after puparium formation, disappearing once epidermal cells develop apical extensions (at protein level) (PubMed:25344753). Isoform B: Expressed in the trichomes of stages 11 and 12 embryos and disappears by stage 15 but the cleaved transcriptional activator form svb is still present (at protein level) (PubMed:20647469). Isoform B: Not detected until the blastoderm stage when it is expressed in the head (PubMed:7748792). Isoform B: No expression in the primordial germ cells (PGCs) (PubMed:28059165). Isoform B: In stage 12 embryos, expressed in the trunk, and in stage 14 embryos expressed in the region of denticle belt setae and dorsal hairs (PubMed:7748792). Isoform B: Not detected in the pole cells throughout embryogenesis (PubMed:7748792). Isoform B: Expressed in the pupal tarsal segments in several segmentally separated stripes (PubMed:21527259). Isoform D: Expressed in the germinal stem cells of the germarium and later in the nurse cells (at protein level) (PubMed:7748792). Isoform D: Uniformly expressed in early cleavage and blastoderm stage embryos (at protein level) (PubMed:7748792). Isoform D: At germ band extension (stage 8), expression levels decrease rapidly and becomes localized to the pole cells in the posterior midgut pocket (at protein level) (PubMed:7748792). Isoform D: In stage 14 embryos, expressed in the forming gonads and some dispersed cells presumed to be pole cells lost during cell migration (at protein level) (PubMed:7748792). Isoform D: Expressed in male and female embryos, and in the germ cell in the gonads of male and female larvae (at protein level) (PubMed:7748792). Isoform D: Detected in adults, and in males is expressed in the apical part of each testis (at protein level) (PubMed:7748792). Isoform D: Expressed during early oogenesis in all female germline cells with slightly lower expression in early egg chambers (stages 2-4) (PubMed:10648246, PubMed:15371353). Isoform D: Weakly expressed in the apex of the testis (PubMed:12051822, PubMed:15371353). Isoform D: Expression levels in PGCs remain constant from stage 4 to stage 11, but decrease from stage 12 to stage 17 (PubMed:28059165). Isoform C: Weakly expressed in female germline stem cells and dividing cystocytes, and is very weak in early to middle stages of egg chamber differentiation (PubMed:10648246, PubMed:15371353). Isoform C: Expression levels are highest from middle to late stages of egg maturity but this is still relatively weak compared to isoform D (PubMed:10648246). Isoform C: Expressed in PGCs throughout embryogenesis but at a much lower level than isoform D (PubMed:28059165). Isoform C: Weakly expressed in the apex of the testis (PubMed:12051822, PubMed:15371353)
+Expressed postembryonically at all larval and adult stages, including the developmentally arrested larval state known as dauer stage (PubMed:26438299). Expressed in neurons of the head and tail, including the motor neurons VD1, DA3, and DA7 (PubMed:26438299). Also expressed in the anal depressor muscle, anterior and posterior intestinal cells, and the head and body wall muscles (PubMed:26438299). Expressed in the PDE sensory neuron pairs and rare, transient expression seen in migrating distal tip cells of larval L3/L4 stages (PubMed:26438299)
+Expressed during morphogenesis in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells (PubMed:15066124, PubMed:15102704). First detected in the Ea and Ep cells until the 24 cell stage (PubMed:15066124, PubMed:15102704). At the 24 cell stage detected in 5 cells including AB descendant cells and also the Ca and Cp cells (PubMed:15066124). At the 200 cell stage, detected in two pairs of MS descendant cells (PubMed:15066124). Thereafter detected in a subset of cells at each stage up to approximately the 400 cell stage, becoming undetectable just before morphogenesis (PubMed:15066124). During morphogenesis detected in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells up until early L1 larval stage (PubMed:15066124, PubMed:15102704)
+Expressed zygotically. First detected at the 30% epiboly stage
+Expressed during vitelline membrane biosynthesis
+Expressed in heart and midgut at 9.5 day post-conception (dpc). Expressed in floor plate, peripheral nervous system, lens epithelium, skin, midline dorsal aorta, lung, kidney and testis from 10 dpc onwards
+Expressed in the ventral neural tube at 11.5 dpc
+Predominantly expressed in developing brain (PubMed:31820119). Preferentially expressed in the developing cortex and cerebellum from gestational weeks 14, 20 and 28 and in the frontal cortex of brains from weeks 21 and 23 (at protein level) (PubMed:31820119)
+Expressed from embryogenesis to adulthood (PubMed:33378643). Expressed in the germline and somatic cells of L4 stage larvae (PubMed:33378643). In the germline of L4 stage hermaphrodites, uniformally expressed in germ cells from the proliferative mitotic zone to the meiotic mid-pachytene region (PubMed:33378643). Expression reduces in germ cells transitioning through diplotene and meiosis I and II and increases again before cells begin spermatogenesis (PubMed:33378643). During oogenesis, expressed in the distal germline and through the bend in the ovotestis (PubMed:33378643). Not expressed in maturing oocytes or the embryonic germline (PubMed:33378643). Expressed in most somatic cells throughout development, with high expression in intestinal cells (PubMed:33378643)
+First detected shortly after the mid-blastula transition and is localized to the presumptive mesoderm at mid-gastrula stages. Expression persists in the lateral plate mesoderm at neurula stages and is found in the pharyngeal arches and otic vesicles from early tail bud stages onward. Expressed in the pre-placodal ectoderm domain at stage 18
+Widely expressed throughout the embryo at 11.5 dpc. Enhanced expression in the developing pituitary at 11.5 dpc. Expressed in developing lung from 13.5 dpc. At 16.5 dpc, confined to airway epithelial cells, developing sensory area of the cochlea and intestinal epithelial cells, particularly concentrated at their apical border
+Expressed early during sporulation
+Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids
+First detected at low but consistent levels by early neural stage (stage 16) with expression then increasing by stage 19 and remaining relatively constant until a sharp drop off at later neurula stages (stages 23-28). However, there is a sharp increase in expression between early (stage 30) and mid-tadpole stages
+In the embryonic central nervous system, detected at 12.5 dpc when expression is observed in all areas of the brain including the cerebellum (PubMed:15567717). In the embryonic cerebral cortex, detected at 14.5 dpc with levels increasing at 18.5 dpc (PubMed:15567717)
+Early marker of the sclerotome and of a subset of vascular smooth muscle cells, expressed also in outgrowths of epithelial cells, in ectodermal epithelial cells and in restricted regions of the central nervous system. Detected first at 7.5 dpc in the paraxial mesoderm adjacent to the neural fold. At 8.5 dpc, segmental expression in the first 8 or 9 somites. Expression proceeds caudally in parallel with somite maturation and is restricted to the sclerotome. As the somites mature, expression moves away from the axial structures, becomes transiently restricted to a subset of early myotomal cells at the dorsal medial lip and is subsequently down-regulated. At 10.5 dpc, expressed only in the most caudal immature somites. At 9.5 dpc, present in the dorsal aorta. At 11.5 dpc, restricted to the vascular smooth muscle cells of caudal region of the dorsal aorta. At 12.5 dpc, expressed in the distal epithelium of the tongue and in Rathke pouch (anterior pituitary). By 13.5 dpc, also detected in tooth buds. Expression in the abdominal aorta continues through 11.5 to 15.5 dpc. Detected in the vertebral vessels at 12.5 dpc, in the carotid vessel at 13.5 dpc and in arcuate and interlobular arteries of the kidney at 15.5 dpc. In neonates, present in palatine glands, epithelial root sheath of the tooth and epithelial hair sheath. In the nervous system of neonates, expressed in the olfactory lobe, olfactory epithelial cells and cerebellar cortex. Expressed in the male urogenital system during late embryogenesis: at day 14.5, expressed in the outbuddings of the pelvic region of the urogenital sinus, and, at lower levels, in the prospective urethra. Expression is confined to the epithelial cells that are invaginating into the surrounding mesenchyme, with highest levels at the leading edge. At 17.5 dpc, present in the developing ventral, dorsolateral and anterior prostatic buds, in the nascent bulbourethral glands, as well as in the epithelial ducts that join the glands to the prospective urethra. During postnatal growth and morphogenesis of the prostate, high expression is maintain at sites of ductal outgrowth and branching. In the developing testis, detected at 14.5 and 17.5 dpc in the medullary cords, which form seminiferous tubules
+First expressed at or just after midblastula transition (stage 8). Maximally expressed at stage 10 as an equitorial mesoderm band, more prominently on the dorsal side and around the invaginating dorsal lip
+Expressed in berries at start ripening (veraison), when the concentrations of methylated anthocyanins begin to increase
+Expressed at a high level during germination in the aleurones cells under the control of the plant hormone gibberellic acid and in the developing grains at a low level
+Is strongly and equally detected in planulae, in primary polyps (9d), and in both adult females and males (at protein level) (PubMed:33060291). Transcripts are expressed early in development in ectodermal cells of the gastrula, then increases in early planula and by the late planula spreads in expression to endodermal cells. In primary polyps, they are expressed in ectodermal sensory cells and multiple endodermal ganglion cells that send their processes in different directions all around the body (PubMed:33060291)
+Ubiquitously expressed across all developmental stages
+Specific to the midveins, containing narrow procambial cell files. Expressed in procambial cells of leaf primordia, roots and embryos, prior to the completion of xylem differentiation
+Expressed in the growing regions of roots, coleoptiles, internodes and leaves
+Expressed in the floor plate of the spinal cord at 11 dpc and also in the ventricular zone at 16 dpc, but not in adult. In the brain, expression is more significant at 16 dpc than at adult, with high expression in the cortex, pontine area and choroid plexus. Detected in the otocyst at 16 dpc
+Activated during early microspore development
+Expressed in developing seeds. Expressed in embryo, but not in endosperm (at protein level)
+At 10.5 dpc, expressed in heart, skeletal muscle and neural lineages. At 11.5d pc, expressed in heart, dorsal root ganglia and neural tube. At 12.5 dpc, expressed in heart, skeletal muscle, dorsal root ganglia, neural tube and retina. Strongly up-regulated in muscle between 14 and 19 dpc as a result of motor innervation
+During hair follicle growth cycle, it is detected at low levels at 17.5 dpc (hair folliculogenesis stage), increases to a maximum expression level by P10 (anagen), declines to the basal level at P15-20 (catagen to telogen), and again increases at P25 (re-entry into the next anagen)
+First expressed at 16 days postpartum (dpp). Level increases until 20 dpp and is maintained into adulthood (at protein level)
+Expression in flowers increases as the flowers develop
+Highly expressed both in embryos and adult tissues. In 9.5 dpc and 10.5 dpc embryos, it is expressed in the tail bud, limb buds and somites. Expressed in the same pattern than MIB2 in the skin and intestine at postnatal day 1 (P1) and in the hair follicle in the skin in the adult
+Expressed in all 3 larval instars and adults, but not pupae or eggs
+Not expressed in embryos. Mainly expressed in adult
+Expressed since postnatal day (P) 21, peaks at P30, and gradually decreases in the testis of aging mouse (PubMed:20008104, PubMed:20188161). Coexpressed with transition proteins during late spermiogenesis (PubMed:28366643). Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863)
+During embryonic stage 10-12, expressed throughout the tracheal primordia. At stages 13-15, expression is lost from the tracheal dorsal trunks (DTs) but is maintained in branches still undergoing active elongation and migration: the dorsal branches (DBs), visceral branches (VBs), lateral trunk branches (LTs) and ganglionic branches (GBs). Notably, expression is enriched at regions of filopodia formation such as the distal tips of the DBs, LTs and GBs
+Expressed from embryogenesis to adulthood (PubMed:26811380). Expressed in head neurons in L3 and L4 larvae (PubMed:31264582)
+Accumulates progressively in cones and glandular trichomes (lupulin glands) after flowering
+At 11.5 dpc, isoform 1 and isoform 2 are widely expressed in the developing nervous and vascular systems and are also found specifically associated with vimentin in endothelial cells. By 15 dpc, isoform 1, isoform 2 and isoform 3, are found coexpressed with neurofilament, peripherin and internexin in the peripheral nervous system (at protein level). In the developing embryo, isoform 2 is detected as early as 5 dpc, whereas isoform 1 is first observed at 9 dpc in the nervous system and mesodermic derivatives. Isoform 3 is observed later in neurons at 15 dpc
+Between 7.5 dpc and 8.5 dpc, as the heart tube forms, expressed in splanchnic mesenchyme comprising the mesocardium and adjacent to foregut endoderm as well as in both splanchnic mesoderm and in ventral foregut endoderm. At 10 dpc, continues to be expressed in ventral endoderm and splanchnic mesoderm but is not expressed in the myocardium of the heart (PubMed:14667410). At 10.5 dpc, expressed in cardiomyocytes located in the outflow tract (PubMed:22343712)
+Expressed at high levels throughout the developing embryo, except in the heart and liver. In the developing brain, expressed at high levels in the ventricular zone (vz) in the forebrain and midbrain. Expression in the developing brain is maximal around birth and gradually decreases until it is completely absent from the adult brain
+During anther development, undetectable at pre-meiosis and microspore development stages, but expressed in large quantities at the late stages of pollen maturation
+Expression in uterus varies during the estrous cycle, with highest levels during proestrus and estrus stages and declining sharply from metestrus to diestrus. During early pregnancy, uterine expression is markedly increased at 1 dpc, declines rapidly at 2 dpc and is almost undetectable from 3 dpc to 6 dpc
+Expressed by developing cerebellar Purkinje cells. Expression coincides with the growth of the dendritic tree, after Purkinje cells have finished their migration from the ventricular zone (from 15 dpc until 21 dpc). Expressed in the adult
+First observed in young embryonic SAM. Later confined to the boundaries between cotyledon primordia and the SAM. In mature embryos, localized around first leaves primordia. Only weakly present in vegetative SAM. In inflorescence, observed at the boundaries between floral organ primordia. In callus, expressed during transition to shoot development, with a progressive restriction to specific areas corresponding to future shoot apex
+Expressed ubiquitously during embryogenesis and larval development (at protein level) (PubMed:23577193). Expressed in wing disks and developing eyes in both actively dividing cells (anterior to the morphogenetic furrow) and differentiated cells (posterior to the morphogenetic furrow) (at protein level) (PubMed:23577193)
+Expressed in the unfertilized egg, in the blastocyst, as well as in the developing embryo and fetus. Expressed in developing skin
+Early expressed in the axonal compartment in developing neurons, and persists in this polarized distribution in the adult brain
+Not detected in 8.5 and 14.5 dpc embryos. Expressed early in postnatal liver reaching maximal levels at one month of age in both male and female mice. The expression in female mice is lower than in males across the lifespan
+Expressed in embryo from stage 10 in all ectodermally-derived epithelia secreting cuticle. During germband retraction, epidermal expression is strongest in the T2, T3, and A8 epidermal parasegments, but not detected during primary branching. Pan-tracheal expression is first detected at stage 14 and continues during later stages coinciding with lumen growth and cuticle deposition. In addition to tracheal expression, expressed in epidermis, foregut, and hindgut
+Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases
+Present in vegetative cells
+Initially found in all tissues of the posterior region in 8.5 and 9.5 dpc. Embryos, it eventually become specifically located in neural tissue
+Expression in brain gradually increases from postnatal day 1 onwards and reaches maximum levels by postnatal week 3
+Expressed both maternally and zygotically. Ubiquitous embryonic pattern of expression declines during embryogenesis and disappears from most cells in comma-stage embryos coincident with the completion of the majority of embryonic cell divisions. Expression levels drop and become restricted and dynamic during postembryonic development (PubMed:12606285). During the development of distal tip cells, expressed asymmetrically between the daughters of the Z1.a and Z4.p cells; asymmetric expression is regulated by wrm-1, a component of the Wnt/MAPK pathway (PubMed:17476329). In the gonads, expression is restricted to the proliferating distal germline cells (PubMed:12606285, PubMed:21558371). In germline cells entering meiosis, expression is repressed by gld-1 (PubMed:21455289, PubMed:19758560)
+Transiently expressed in the developing mouse skeleton between day 13.5 dpc of embryonic development and 5 months of postnatal development. Absent in undifferentiated mesenchymal cells. Isoforms 1 and 3 are significantly increased with the onset of chondrogenesis, whereas Isoforms 2 and 4 are detected at a later stage
+Expressed in brain at 14 dpc
+Expressed during the asexual blood stage in late rings, trophozoites and schizonts (at protein level) (PubMed:27653778, PubMed:24983235, PubMed:32184257). Expressed in gametocytes (at protein level) (PubMed:27653778)
+Detectable at stage 9 and prominently expressed from stage 10 (early gastrula) to stage 30 (tadpole). Restricted to the dorsal segment of the gastrula. At stage 10, expressed exclusively in the dorsal blastopore lip and the Spemann-Mangold organizer. Excluded from the dorsal margin of the Spemann-Mangold organizer. At stage 11, expressed in the anterior prechordal plate. By blastopore closure, expression restricted to the anterior midline. At early neurula, expressed in the midline anterior to the tip of the notochord in cells of the endoderm and overlying neural ectoderm
+Activated in the tapetal cells in early anther development and continues to be expressed until tapetal dissolution
+Expressed during sporulation (at protein level)
+Expressed at low levels in the tail tip in both males and hermaphrodites from the L4 larval stage
+During embryogenesis, present in the embryo at the globular and heart stages. Detected in the funiculus and vascular tissues of the siliques. During germination, restricted to the proximal part of the radicle having root hairs to later expands toward the meristematic region, except for the root tip. Strongly expressed in hypocotyls and cotyledons 6 days after imbibition. Present in primary leaves. In developed flowers expressed in sepals and filaments. In developing siliques, present at both ends, the stigmatic papillae and the abscission zone
+Detected in the 7, 11, 15, or 19 dpc
+Expressed at low levels in the embryo. Expression increases after hatching and during larval stages and is followed by a decrease in adults (at protein level)
+Present in growth phase and during development, although levels declined as development proceeded
+During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells. In brain, levels of ENO1 decrease around 10 dpc and then gradually increase to adult age. In embryonic heart, ENO1 levels decrease rapidly during cardiac development
+Ubiquitously expressed at day 9.5 dpc, with high levels in the endoderm, down-regulated at day 10.5 dpc, and expressed again at day 11.5 dpc, with high levels in the brain and neural tube. Then levels increase steadily until day 14.5 dpc
+In gastrulation-stage embryos, it is confined to the node between 7.5 and 8.25 dpc In sections of 14.5 and 16.5 dpc. embryos, it is strongly expressed in neural tissue (brain and ganglions). Also weakly expressed included in kidney tubules, retina, respiratory epithelium, biliary tract and liver. In the adult kidney, it is weakly but specifically expressed in distal tubules located at the cortico-medullary border, which corresponds to the site of cyst formation in mice lacking Nphp3. Expressed in retina and liver
+More abundant in developing cells
+First detected around day 10 of embryonic development in the preplate, at day 12.5, in the cortical plate and intermediate zone, and from day 16.5 to 18.5, in a rostro-caudal gradient in the subplate. In the thalamus, expression is first observed at postnatal stage, P7, and weak expression continues in later postnatal and adult stages
+Expressed in all life stages examined, including adults, spiderlings and eggs
+Expressed ubiquitously throughout embryonic development
+Only expressed in early developing buds and anthers, mRNA is first detected in 2-3 mm buds, expression levels peak in 4-5 mm buds and are absent in later stages of development
+Low expression in 12-day-old testes when the majority of advanced cells are in zygonema, but increased by 14 to 18 days of age when most spermatocytes are in pachynema
+PG1 appears when fruits start to be coloured. When fruits are orange, both PG2 and PG1 are present. In fully ripe fruit, mostly PG2 is expressed
+During embryogenesis it is predominantly expressed in several regions of the developing central nervous system and the urogenital ridge. Expression in the CNS is confined to the neural tube, the hindbrain, the neural retina and the olfactory epithelium, and coincides with the presence of proliferating immature neuronal precursor cells. In the adult mouse, A-Myb is expressed at high levels in type A spermatogonia (stem cells), and preleptotene and pachytene spermatocytes, with concomitant down-regulation of expression upon terminal differentiation of these cells into mature spermatozoa, and in B lymphocytes located in germinal centers of the spleen (PubMed:7813437, PubMed:8084617). Present in mid-late pachytene and diplotene spermatocytes, but not in late zygotene/early pachytene cells (at protein level) (PubMed:21750041)
+Expressed throughout the developmental stages
+Monoallelic expression of paternally derived allele was observed in all fetal tissues examined, including brain, skeletal muscle, kidney, adrenal, tongue, heart, skin and placenta. In 75-day fetus, expressed in the amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle and liver
+Isoform a: Expressed in larval stages L1 and L2 and in adult animals. Isoform b: Expressed in embryos, larval stages L1 and L2 and in adult animals
+Expressed at the early stage of germination and during the conversion of glyoxysomes to peroxisomes
+Expressed in larvae and in adults
+Infant brain has higher levels of WNT10B than adult brain
+Specifically expressed during anther development, from the uninucleate pollen stage to the tricellular pollen stage, with the highest expression at the tricellular pollen stage
+High levels in the developing ciliary and superior cervical ganglia
+At postnatal day 1, highly expressed in upper neocortex and also detected in the olfactory bulb, but not in the striatum
+Expressed in the embryo and larva
+Found in the embryonic CNS with little expression elsewhere
+Present throughout development, with expression levels lower in larvae than other life stages
+At 12 dpc, detected in the developing brain, eye, lateral lip of the dermomyotome, somites and branchial arch
+Accumulates progressively during seeds development
+Appears in the mid embryonic period and becomes abundant at 16 dpc to 19 dpc. Postnatally its expression decline and only minimal levels were present in adulthood
+Expressed early during mouse embryogenesis in the yolk sac mesoderm and in the developing vascular system. At 7.5 dpc, it is expressed in the primitive blood islands where the first endothelial cells differentiate. At 10.5 and 13.5 dpc expression is restricted to endothelial cells
+Specifically and transiently expressed in two cell layers of the seed coat (ii2 and ii3) at an early stage of seed development (at protein level)
+Expressed at a relatively steady level during vegetative growth and development
+First detected at 7.5 dpc in the neuroepithelium at the time of initial neural tube closure. Also expressed in cranial mesenchyme, branchial arches, somitic mesoderm and lateral mesoderm. At later stages it is expressed in the eyelid epithelium, submandibular glands, whisker and hair follicles, sympathetic glanglia, inner ear, thymus, testis, kidney, esophagus, lung, stomach, trigeminal and dorsal root glanglia
+Expressed strongly in fetal brain
+Expressed at late stage of development (20 to 24 hours)
+Expressed in the neural tube, dorsal root glanglia, spinal nerves and myotome at 4 dpc. Expressed in neuronal and glial cell populations as detected at 10 dpc (at protein level)
+Expressed during pollen germination and tube growth
+Expressed in the spermatheca and spermathecal-uterine junction at the L4 lethargus stage of larval development and in uterine toroid cells of young adults. Not expressed during early and mid-L4 stages of larval development
+S phase-specific expression
+Expression is highest in adults. In the embryo, maternal transcript levels are reduced during blastula and gastrula stages. Expression increases during segmentation and later stages
+Localized primarily to the hypocotyl of germinating seedlings
+Constantly expressed throughout development
+Expressed at early stage of flower development in stamen anlagen before stamen initiation, and at later stage in lodicule and ovule primordia initiation region
+Expressed in the developing spinal cord in the ventricular zone and down-regulated in the lateral zone at 11.5 dpc (at protein level) (PubMed:18539116). Highly expressed in motor neurons that emerge from the ventricular zone at 11.5 dpc (at protein level) (PubMed:18539116). At 12.5 dpc, highly expressed in motor neurons in medial median motor column (MMCm), which innervate dorsal axial muscles (PubMed:18539116)
+Increases in the peel during fruit maturation
+At the begin of fourth week of development detected in cytoplasm of somite cells. Between the sixth and eighth week of development detected in cytoplasm of limb bud cells
+Expressed in 24-day-old and adult testis, but not in 4-, 10- and 16-day-old testis
+In early neurulae (stage 13), regionally restricted expression seen in a broad anterior domain surrounding the anterior end of the mediodorsal groove of the neural plate. Within this broad ectodermal domain, expression seen in two bilateral patches flanking the mediodorsal groove. In late neurulae (stage 19), a strong expression is seen in the anterior ectoderm. At early tail bud stage (stage 25), expressed in three distinct areas within the pharyngeal region and in the ventral region of each otic vesicle. At stage 33, expression within the otic vesicles extends further laterally. However, in subsequent stages (stages 40, 47) expression remains restricted to the ventral and lateral regions of the vesicles
+Early stage of adult feeding
+Initially expressed in the testis at 10 days of age, expression increases until 2 weeks of age whereafter protein abundance remains consistent (at protein level)
+Found in the extra-embryonic ectoderm at 5.5 dpc, 6 dpc and 6.5 dpc. At 7.5 dpc, is exclusively detected in chorion, and at 8.5 dpc is present only at its free margin. Expression is not detected in the ectoplacental cone at any stage of development, nor is placental expression detected after 8.5 dpc
+Expression increases during seed development
+At 17 dpc during embryonic development, highly expressed in brain regions including the striatum, olfactory bulb, septal nuclei, lateral habenula, pyramidal CA1-CA2 cell layers of the hippocampus and in the neuroepithelial cells of the ventricular zone. On the day of birth, expressed in the regions of the brain including hippocampus, thalamic nuclei, cortex and cerebellum
+Maximum levels of expression in prespore cells, but also expressed in prestalk cells at the slug stage. Developmentally regulated with levels peaking at culmination
+Present in the vegetative phase and decreases with the start development
+First detected at neurula stages, and are localized anteriorly in the neural plate, neural crest and weakly in the spinal cord. As development proceeds, localized throughout the CNS, eye vesicle, and the streams of migrating branchial and hyoid neural crest and is also present weakly in the cement gland. Embryos at stage 27 show a strong expression in the retina and spinal chord, as well as a weak expression in the forebrain and midbrain. Predominately located in the outermost marginal layer of the ventral hindbrain, where terminally differentiated neurons are located
+Expressed during sporulation; in mother cell compartment, then located in the spore coat
+Accumulates in young and mature leaves where the dominant ent-kaurane diterpenoid maoecrystal B accumulates
+Expressed at constant level during the cell cycle
+Found when sporogenous cells are in early meiosis. Disappears totally as the microspores go into interphase, when the tapetal cell layer degenerates
+Expressed in embryo at 12.5 dpc and 16.5 dpc
+Highly expressed in all 6 vulval precursor cells (VPCs). At the time of inductive signaling, expression forms a gradient in response to inductive signal: expression is low in P6.p, intermediate in P5.p and P7.p and undiminished in P3.p, P4.p, and P8.p. Later, expression becomes strong again in P5.p and P7.p
+Expressed during seed maturation. Expressed in maturing seeds about 1 and half weeks after flowering. Expression continues steadily thereafter until it decreases in the seed-drying stage, reaching undetectable levels in mature seeds
+This protein is predominantly expressed in the endoderm of sea urchin pluteus stage larvae
+First observed in the embryo proper at the four-cell stage. Later expressed throughout the embryo from the eight-cell to the bent-cotyledon stages. Until the torpedo stage of development, mostly concentrated at the root pole. Hardly detected in the suspensor. Present in seedling roots. In mature and fully differentiated young roots, restricted to root tips
+Expressed during embryogenesis and pupation
+Transcription starts at stage 10.5 (mid-gastrula)
+Increasingly expressed by 10 dpc. Expression peaks at postnatal day P7 and stays at lower levels in adulthood. First expressed within proliferating neuronal progenitor cells of the neuroepithelium, becomes down-regulated during neuronal migration, and is later reexpressed in the dendritic compartment of postmitotic neurons. In the developing neocortex, it is strongly expressed in the proliferative ventricular zone and the developing cortical plate, yet is conspicuously less prominent in the intermediate zone, which contains migrating cortical neurons, it forms a honeycomb pattern in the neuroepithelium by labeling the cell periphery in a typical adherens junction pattern. By 18 dpc, its expression shifts primarily to nascent apical dendrites, a pattern that continues through adulthood
+At 8.5 dpc, detected in the gut epithelium from which the pancreatic buds are formed. Transient expression in pancreatic ducts, endocrine and acinar cells. Down-regulated around 10.5 dpc when expression becomes restricted to differentiated beta-cells
+Found in young seeds 2 to 5 days after fertilization, but not expressed in mature seeds
+Expressed in the shoot meristem and root epidermal cells in germinating seeds
+This antigen occurs in adults and sporocysts but not in cercariae, eggs or newly transformed schistosomula. It is a developmentally regulated protein
+Expressed throughout the developing central nervous system (CNS). Expressed in the cortex, diencephalon, and brainstem, with the most intense staining in the striatum and trigeminal ganglia at 18 dpc (at protein level). First detected in discrete foci in the developing epidermis of 13 days old embryos, later in the hair follicle placodes of 15 days old embryos. Expressed in the ventral and lateral margins of the spinal cord from 9.5 to 13.5 dpc, where post-crossing commissural axons project longitudinally. Expressed in superior sympathetic cervical ganglia (SCG) at 14.5 and 16.5 dpc, a stage when the SCG is comprised primarily of proliferating sympathetic neuroblasts. In 17 days embryos and 1 day old newborn, expression is limited to suprabasal keratinocytes and is not seen in pelage follicles until 3 days postpartum. In 7 days old neonatal skin, expression occurs throughout the epidermis and in the outer cell layers of hair follicles
+In floral tissues, expressed in pollen grains and fertilized ovules until they develop into seeds, and, at low levels, in the styles. Observed in germinating seedlings, and later confined to shoot and root apical meristems. Accumulates in emerging leaves and in the vascular tissue of adult leaves
+Expressed in Q neuroblasts during larval development with higher expression in migrating QR.ap neuroblast descendents than in QL.ap neuroblast descendents
+Expressed in the embryonic heart. Expressed in the ventral node, cardiac crescent and blood islands at 7.5 dpc. Expressed in the cardiac crescent, anterior lateral mesoderm and in trunk paraxial mesoderm at 8 dpc. Expressed in forebrain-midbrain boundary, branchial arches 1 and 2, heart and somites at 9.5 dpc (at protein level). Expressed in the coelomic epithelium and in cells in the underlying nephrogenic mesenchyme of the genital ridge at 10 dpc. Expressed in the genital ridge and the presumptive adrenal area at 10.5 dpc. Expressed in the gonad and in the adrenal anlagen at 12 dpc. Expressed in the cells of the adrenal cortex at 14 dpc. Expressed throughout the embryonic heart, as well as in the node and the lateral plate mesoderm (LPM), that are responsible for initiating and maintaining left-right patterning. Expressed in the crown cells of the node
+Expression is relatively low in mycelia and reaches the highest level in the primordia
+Expressed between blastula and neural plate stages. Detected in the ventral ectoderm of the gastrula, the region fated to give rise to epidermis and a site of active BMP signaling
+Detected at the vesicle stage of developing glomeruli, expressed in invading endothelial cells in the glomerular cleft at the S-shaped stage and is later expressed only at the basal aspect of maturing podocytes
+Expressed at high level in the brain embryo at 14.5 dpc. Expressed at lower level in the brain embryo at 10.5 dpc and 19.5 dpc
+Expressed during fruit ripening (PubMed:23265513, PubMed:25849978). During storage, highest expression in fruits on day 12, decreasing sharply thereafter until end of storage (day 18) (PubMed:23265513). Expression is low in immature growing fruits, but increases significantly during the mature stage with the highest expression 120 days after full bloom. Expression in fruits is rapidly increased during storage at 25 degrees Celsius, with the highest expression on day 12, after which the expression decreases steadily until the end of storage (PubMed:25849978)
+Expressed in sporozoites (at protein level)
+Isoform 2-isoform 4 are detected at embryonic day 4 (ED4) in both visceral and somatic motor neurons of spinal cord and is highest at ED6. Isoform 1 is not expressed until ED 6 in spinal cord. At ED 11 both isoforms display comparable levels
+Expressed in the embryo proper and both layers of the integument at 2 days after pollination (DAP). At 3 DAP, strongly expressed in the outer cell layer of the embryo and at lower levels in the integument and the outer endosperm layer (prealeurone layer). From 4 DAP to 6 DAP, expressed in the integument, the scutellar epithelium and embryo axis. Expression stongly decreases from 8 DAP to disappear completely at 10 DAP. Expressed in young seedlings developing roots at the root hair-forming side of epidermal cells
+Expressed both zygotically and maternally in embryos. Isoform A and isoform C have high expression throughout embryonic development and very low expression in later developmental stages. In adults, isoform A is a male-specific isoform and isoform C a female specific
+Detected in the early blastula, 2.5 hours post fertilization (hpf), before the onset of zygotic gene expression, and expression progressively increases, reaching a peak at late gastrula stages (9 hpf), before decreasing by 26 hpf. Maternal transcripts are detected throughout the blastoderm. Ubiquitous expression continues until early somitogenesis (12 hpf), after which transcript levels gradually decrease in the trunk (15-18 hpf), with strong expression becoming restricted to the head by 25 hpf
+First observed during early cell morphogenesis in the embryo, levels increase during later embryonic development and remain at comparable levels throughout larval and adult stages
+Expressed only during gastrulation
+Expressed in mesenchymal cells in proximal ureters at 14 dpc, preceding the smooth muscle precursor cells differentiation and the expression of contractile proteins from 15 dpc
+Expression reduced during tuber development
+In the embryo, levels fall after fertilization until the 2-4 cell stage and then increase rapidly
+Expression is cell cycle-dependent, with low levels in mitosis. The expression starts to increase during late G1 until the S/G2 transition (at protein level)
+Expressed both maternally and zygotically throughout early development. Becomes visible in the animal hemisphere of the embryo during the cleavage and blastula stages. At the gastrula stages, expressed broadly throughout the marginal zone and animal pole tissues. At the neurula stages, it shows the restricted expression in dorsal tissue. At later stages, expressed in the cement gland, brain, somite, notochord and pronephros
+Associated with tumorigenic conversion
+From 9.5 to 11.5 dpc, expressed in the branchial arches, otic vesicle, limb buds, somites, craniofacial mesenchyme and tail buds. At 14.5 dpc, expressed in the developing tongue, nasal cavity, palate, adrenal gland, in the forebrain, dorsal root ganglia and in the somites. At 14.5 dpc, also detected in lung, rib cartilage, kidney and intestine (at protein level). In the kidney, expression peaks at 15 to 16 dpc and decreases thereafter, but persists in adulthood
+Expression increases during leaf development. Not expressed in senescent leaves
+In the sciatic nerve, first detected at postnatal day P4, increases to a maximum at day P14 and then declines to moderate levels in adulthood. In the brain, onset of expression is at day P1, levels increase to reach a maximum at P20 and decline slightly to adulthood
+Expressed during the asexual blood stage, specifically during the late trophozoite and early schizont stages (at protein level) (PubMed:16216221, PubMed:18525026, PubMed:18554328, PubMed:19633266, PubMed:22379140, PubMed:26094711). Some expression has been found also at the ring stage (at protein level) (PubMed:18525026, PubMed:18554328, PubMed:22379140, PubMed:26094711). Highly expressed during the sexual blood stage (PubMed:12543146)
+Expression between 15-20 days post-implantation occurs only in the kidney of the male fetus and not in the female, whereas a similar expression is found in adult male and female kidneys
+At 8 dpc expressed in the lateral plate mesoderm of the primitive streak. At 9.5 and 10.5 dpc expressed in the nasal placodes, maxillary and mandibular processes, posterior part of the hyoid arch and the progress zone of the limb buds and the presomitic mesoderm. At 11.5 dpc expressed in the dorso-lateral region of the somites (mostly in the myotome) and in the otic vesicle. At 11.5 and 12.5 dpc expressed in the distal lung mesenchyme, with a strong expression in the accessory lobe of the lung
+Expressed in limb mesenchyme at 10.5 dpc. Expressed in tooth, submandibular glands, thymus, thyroid, vibrissa follicles at 14.5 dpc
+Detected in testis from postnatal day 20 onwards
+Synthesized during sporogony
+In larvae, highly expressed in the tracheal system. Weak expression is also detected in other larval tissues including the gut and epidermis
+Expressed in females only
+In the cerebellum, expression increases post-natally, following maturation of this tissue (at protein level)
+Expressed during embryonic development in the skin starting at embryonic day 12 with the formation of the basal layer of the skin
+Produced during the exponential death phase of growth, just before sporulation
+Isoform 2 is weakly expressed from 7.5 dpc and the expression level steadily increases through gestation. At 9.5 dpc and 10.5 dpc is first detected colocalizing with embryonic blood cells within the region of the septum transversum and within the cardiac chambers and dorsal aorta. At 12.5 dpc expression is found in the ventral neural tube and in the trigeminal ganglia and in the liver and dorsal root ganglia. Expression persists in the liver, dorsal root and trigeminal ganglia at 13.5 dpc and weaker expression becomes apparent in cardiac and skeletal muscle. At 16.5 dpc expression is detected in liver, myocardium, tongue, bronchial epithelium, gastrointestinal epithelium, cartilage and forebrain neuroepithelium
+Strong expression in early embryos with a peak at 10.5 dpc. Expression is down-regulated at 17.5 dpc, and is nearly absent during postnatal development. In adult testes, prominent expression in late but not early spermatocytes
+Expressed during seed maturation (PubMed:11950969, PubMed:9816677, PubMed:15331088). Appears in maturing seeds approximately 3 weeks after flowering and thereafter the level is continuously increased till the late stage of seed maturation (at protein level) (PubMed:15331088). Detected in maturing seeds approximately 2 weeks after flowering and expression is maintained at a substantial level thereafter until the late stage of seed maturation (PubMed:11950969)
+Mostly expressed in cotyledons during all steps of embryogenesis, and decrease toward the bent-cotyledon stage
+Not detected in unsporulated or partially sporulated oocysts, but present at approximately equal levels in fully sporulated oocysts (sporozoites), bradyzoites, and tachyzoites
+First expressed at the beginning of nuclear cycle 14 in the posterior terminal region. As cellularization proceeds, expression becomes confined to a ring area encompassing the primordium of the hindgut and anal pads. Expression is maintained in this region until the end of embryogenesis
+Associated with mitochondria in spermatids during a narrow developmental window. Mitochondria align on the spindle equator throughout meiotic divisions, but it is not expressed on mitochondria until the last of meiosis II. In postmeiotic haploid spermatids, it is associated with aggregating mitochondria and highly expressed on onion stage Nebenkerns. Expressed at lower levels associated with early elongation stage mitochondrial derivatives. Not detected on more elongated mitochondria
+Detected at 11 dpc, 12 dpc, 14 dpc, 16 dpc and 18 dpc. Expressed in limbs, vertebrae, heart, brain, liver, intestine, tongue, tail, skin, calvaria, lung and kidney of 18 dpc embryos (PubMed:9582436). Isoform 2 is detected at 13.5 dpc and its expression increases from 13.5 dpc to 5 weeks after birth more specially in liver, lung, ileum and heart. The expression slightly decreases after 15 weeks (PubMed:22149965)
+During female embryogenesis, specifically and transiently expressed in germ cells expressing Ddx4: expression starts at 12.0 dpc and decreases after 14.5 dpc, a key period for the sex determination of germ cells (PubMed:21123517, PubMed:32054698). Not expressed in somatic cells or males during embryogenesis (PubMed:32054698)
+Up-regulated in the adult heart
+Expressed widely in young seedling, including roots, shoots, and cotyledons. In older seedlings, present the primary root, shoots, and cotyledons, but not in the root epidermal cells or root hairs. Later observed in the cotyledons and the shoots, but not in the true leaves. In adult plants, accumulates in the primary root and lateral root tips and in the roots near the root/shoot junction. In mature siliques, confined to the tip of the silique in the style just below the stigma and at the base of the silique in the replum and abscission zone of siliques
+Limited expression during embryogenesis with expression in only a subset of neuroblasts. Expressed in neuronal progenitor cells late in nervous system development and in some non-neural progenitor cells. Expressed broadly during larval development stages
+Accumulates only in prespore cells
+Expressed in developing pollen from 7 days before flowering
+Expressed in the spinal cord of newborn animals
+Expressed in the uncrossed ipsilateral retinal ganglion cells (iRGCs) of the peripheral ventrotemporal (VT) region segment in the retina at 16.5 dpc (PubMed:20676059). Expressed during early postnatal brain development in neurons of brainstem and ventrobasal complex (VB) nuclei, including thalamic VB, dorso-lateral geniculate (DLG) nucleus neurons and hippocampal neurons. Expressed in the somatosensory cortex and the brainstem at postnatal day 7 (at protein level) (PubMed:25600870)
+During the estrus cycle, it decreases from the beginning of the cycle until days 13-15 and then increase until ovulation (at protein level)
+Detected at late gastrulae stages within the prospective trigeminal placodes, followed soon in the posterior neural plate where the differentiation of primary neurons occurs. Expression is associated with neurogenesis throughout neural development. Expressed in a ring of tissue that will form the early somites in gastrulating embryos and in a region of paraxial mesoderm called the tailbud domain, which grows out to give rise to somites in the tail in later-stage embryos
+Production of alpha-amylase is hormonally regulated. Germinating embryos produce the hormone gibberellic acid, which within 10 hours stimulates the aleurone cells covering the endosperm of the seed to produce alpha-amylase. The enzyme then degrades the starch within the endosperm for use by the developing plant embryo
+Expressed in the brain of 20 dpc embryos
+Expressed both maternally and zygotically. Expression decreases during larval stages then rises during mid-pupal metamorphosis
+First appears in pachytene spermatocytes and increases in abundance in subsequent stages
+Expressed in embryos, larvae and in adults. Expressed in the developing vulva at the L4 larval stage and in the hypodermis at the L3 larval stage
+Expression is detected in the ventricular zone and neuronal layers of the developing cerebral cortex at 12, 18 and 21 gestation weeks. Differences in regional expression seem to correlate with the process of gyrification of the cortex. Highly expressed in germinal layers of the precentral and parahippocampal gyri, that exhibit little radial expansion and folding, and weakly expressed in germinal layers of the occipital and temporal lobes, that undergo greater expansion and folding
+Expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins
+Isoform 1 is detected at low levels starting from 12 dpc and remains constant until birth. After this levels increase strongly and expression remains high in adults. Isoform 2 and isoform 3 are expressed at a constant high level throughout development
+Expressed at the procyclic stage (at protein level)
+First detected at 9.5 dpc in the neural tube. Expressed at early stages of development in the isthmus and in metencephalic and mesencephalic roof plates. At later stages of development, it is expressed in structures corresponding to circumventricular organs which in adult control the production of the cerebrospinal fluid
+Begins to be significantly expressed at postnatal day 15, reachs a peak at postnatal day 22 and then maintains stable expression level
+Expressed throughout embryonic development and adulthood. In the developing placenta, after 7.5 dpc expression is restricted to the extraembryonic ectoderm, and after 9.5 dpc to subpopulation of labyrinth cells
+Strongly expressed in early embryos 0 to 3 hours after egg deposition (at protein level) (PubMed:18250149). Expression then decreases and is undetectable in larvae and pupae (at protein level) (PubMed:18250149). Strongly expressed in adult females but expression is absent in adult males (at protein level) (PubMed:18250149)
+Highly expressed in embryonic stem cells (ESCs) during embryogenesis: expression starts from 4-cell stage
+Until 48 hpf, highly expressed in developing vascular structures and epidermis. By 48 hpf, becomes restricted to the developing head. By 5 dpf, observed only in the epidermis
+Expression refined to procambial cells during embryogenesis
+Embryo, blastula stage
+Expressed as early as day 8, coincident with the entry of germ cells into meiosis. Expression then progressively increases. Expressed in the pachytene stage
+Accumulates during seed development
+Expressed in brain throughout development. Transiently expressed in hippocampal neurons during the first week after birth, with expression decreasing thereafter
+Expression gradually increases during in vitro ciliogenesis
+Expressed during both vegetative growth and development
+Renal level increases gradually from postnatal day 1 through day 45 in both genders
+First observed in roots and cotyledons of young developing seedlings. Later confined to root tips and vascular tissue around the shoot apex. In flowers, detected in the stamens and at the senescence region of developing siliques
+Down-regulated after synapse formation
+Embryonic expression first occurs in the primitive streak, followed by expression in head mesoderm, somites, and specific rhombomeres of the hindbrain, and later in midbrain and diencephalon. No expression is seen in the node or notochord
+Expressed in the proliferative zones of the fetal neocortex. Expressed at a very high level in the developing ganglionic eminence and at a more moderate level in the cortical plate
+Expressed in larval and pupal stages (at protein level). Expression also detected at early embryonic stages and in adult
+Gastrulation, endoderm-specific protein
+Temporally expressed in embryos and larvae (PubMed:19357781). Expression peaks prior to each larval molt (PubMed:19357781). In L4 larvae, expressed in the hypodermis, in the vulval and anal epithelium, in the excretory pore, the seam cells and at the seam cell boundary (PubMed:19357781). Not expressed in adults (PubMed:19357781)
+Detected around the time of microspore mitosis with a peak in mature pollen grains
+Expressed in differentiating endocrine cells of the anterior pituitary gland between 11.5 and 17.5 dpc. Expressed in all hormone-secreting cell types of the pituitary gland. Expressed in primary sympathetic ganglion chain, spinal cord and in neurons of the dorsal root ganglia at 9.5 dpc. Expressed in chromaffin cells of the adrenal medulla at 13.5 dpc (at protein level). Expressed in the developing central nervous system (CNS). Expressed in midbrain-hindbrain region at 9.5 dpc, in the spinal cord and telencephalon at 11 dpc. Expressed in the forebrain, midbrain, hind brain, spinal cord, cerebellum, olfactory bulb and retina between 11.5 and 14.5 dpc. Expressed in neural stem and progenitor cells of the developing neocortex in both the ventricular zone (VZ) and in the adjacent subventricular zone (SVZ), and in the external granule cell layer of the developing cerebellum between 11 and 16.5 dpc. Expressed in neural progenitor cells at the apical side of the VZ, collectively referred to as apical basal cells (APs; neuroepithelial cells, radial glial cells and short neural precursors) between 10.5 and 16.5 dpc. Expressed in neural progenitor cells in the basal region of the VZ between 10.5 and 16.5 dpc and at later stages in basal progenitor cells (BPs) of the SVZ. Expressed in the cerebellum and pineal gland at 18.5 dpc. Expressed in islet progenitor cells at 10.5 dpc. Expressed in endocrine pancreatic cells, enteric nervous system, duodenum, stomach, thymus, thyroid, adrenal glands at 15.5 dpc
+Preferentially expressed during growth and aggregation
+At 9.5 dpc it is expressed in the somites and in mesenchymal cells of the head and the branchial arches. At 14.5 dpc it is expressed in the surrounding mesenchyme of the kidney and the inner ear. Expression is also observed in the spinal nerves and ganglia, the mesenchyme of the skull, the diaphragm, and the skeletal muscles
+In sporocysts and adult worms
+One day after fertilization, expressed in endosperm, embryo, and the chalazal proliferating tissue. At globular stage, no longer expressed in endosperm, but still in embryo up to the heart and torpedo stages. In mature embryo, expressed in the apical and primary root meristems and dividing vascular tissues. During lateral root formation, expressed in the lateral root primordia and remains during the formation of the emerging secondary root meristem
+Expressed throughout the developmental stages in both head and body from males and females
+Expressed throughout embryogenesis. In the adult ovary, strong expression detected in primitive stage I ovarian follicles with levels declining sharply and becoming negligible in subsequent stages of oocyte development
+In the wing disks levels increase on day 2 fifth larval instar reaching a maximum on day 5, and then decrease sharply on day 6. In the prothoracic glands levels increase sharply on day 2 then remain high throughout the larval-pupal transformation and after pupal ecdysis
+Localized at the cell junctions in the developing fruiting body
+Expressed at a low basal level while growing in a soybean-based medium until day 18 when expression rises significantly to peak at day 23. Expression decreases steadily after day 28 to return basal level by day 42
+Expression starts at 3 days and peaks at 5 days. After, expression levels remain constant from 7 to 10 days
+In dry seeds, expressed in aleurone cells and embryos. Levels drop rapidly but transiently in the embryos of imbibed seeds
+Expressed throughout embryonic development, in the juvenile CNS, but not in the normal adult
+Expressed throughout development and in adults. Ubiquitously expressed in the central nervous system and imaginal disks
+Expressed in various embryonic organs at 6 to 12 embryonic weeks. Detected in vessels from 20-week embryonic organs as well as in endothelial cells from large vessels in neonate
+Expression is generally higher in freshwater eels than in saltwater ones, except in brain, where the levels are the same
+Expression is observed in the cerebellum at 12.5-14.5 days post coitum (dpc). Transcripts are detected prominently in the ventricular zone of both the cerebellar vermis and hemispheres
+First detected at 10 hours post-fertilization (hpf) increasing over the next 24 hours, then decreasing between 48 and 72 hours. Not detected in adult
+Gastrula onwards
+Expressed both maternally and zygotically. First expressed at 4 hpf. Expression is lower by 8 hpf and increases almost constantly thereafter
+Expressed throughout silique development
+Expressed throughout development. Decreased expression in the shoot apex during the transition to flowering. Expressed in developing embryos from the early heart stage until torpedo stage
+Present in reticulate bodies (RB) and much less in elementary bodies (EB) (at protein level)
+Present as a maternal transcript. Early expression is confined to tissues of ectodermal origin. At stage 16, the predominant area of expression is within the developing cement gland. At stage 27, expression is detected in the anterodorsal lateral line placode, the olfactory placode, and the otic vesicle and pronephros
+During seed development, expressed at late embryogenesis and in dry seeds
+First detected at 9.5 dpc
+PRP mRNA levels are highest in the fetal part of the placenta and peak at day 12 of gestation, decreasing gradually until term
+Expressed during the 2-week growth phase of oogenesis, prior to ovulation
+Detected during early embryogenesis, then, gradually decreased, but increased again starting in late gastrula. There are regional diiferences in the level of expression at late gastrula: the involved archenteron roof is the predominant site, while there is weak expression in the neuroectoderm and epidermal ectoderm
+Expressed throughout embryogenesis. Expressed in larvae
+First detected in somites, pronephric duct, midbrain hindbrain boundary, otic vesicle and retina 10-24 after fertilization. When somite formation is complete expression becomes restricted to the retina, the forebrain midbrain, the midbrain hindbrain boundary, the otic vesicle and the branchial arches
+Ubiquitously expressed in developing embryos
+Expressed during parasite asexual blood stages, including in schizonts and free merozoites (at protein level)
+Expressed in embryos (PubMed:17720939). First expressed in the 2 cell stage, with expression increasing at the 8-cell stage, but subsequently decreasing by the 150-cell stage and almost abolished by the 200-cell stage (PubMed:17720939)
+Expressed from the 1-cell stage, before the onset of zygotic expression, then, during gastrulation, at 6 hours post-fertilization (hpf), expression is absent, and at 11-12 hpf, coincident with segmentation, expression returns until 72 hpf
+Found in 12.5 dpc embryo with abundant expression in eye (retinal pigment epithelium) and ear (cochlea, crista ampullaris of the semicircular canals)
+Detected in myoblasts within 24 h after induction of myogenic differentiation preceeding the expression of sarcomeric alpha-actinin. Specifically at early stages colocalizes with ZYX at focal adhesions
+Highly expressed before and after fertilization (PubMed:15201912). During meiosis, found to localize along the chromosome axes during late G2/early leptotene. As prophase I progressed, a lower expression is detectable at zygotene then more reduced at pachytene. Not detected at later stages (PubMed:21217641)
+Detected in the midbrain, hindbrain and craniofacial mesenchyme at 9.5 dpc. At 10.5 dpc and 11.5 dpc, strong expression is detected in the brain, frontonasal processes, maxillary processes, mandibular processes, the second brachial arch, and also in somites and limb buds. In the developing palatal shelves from 12.5 dpc-14.5 dpc, shows graded expression with highest levels in the posterior and middle regions and very low levels in the anterior region
+Expressed in the testis from 20 days of age onwards
+Expressed in the inner cell mass of the blastocyst during preimplantation stage embryonic development
+Expressed in the forespore during sporulation
+Expressed from 20 minutes after fertilization in embryos
+Male-specific expression. First detected 3 to 4 hours after oviposition, corresponding to the beginning of the syncytial blastoderm stage before sex is established
+First present in stems, petioles and the main veins of true leaves in young seedlings. Later accumulates in leaves and present in lateral roots. During transition from the vegetative to the generative stage, preferentially expressed in inflorescence
+Highly expressed in 15 to 21 days postpartum (dpp) testes
+Coexpressed at high levels with B-H1 in embryo and pupae and at low levels in larvae
+Expressed in fetal liver from 5 weeks until 4 months but drastically reduced by 6 months and became non-detectable by 7 months. Expressed in hematopoietic stem cells in 3 weeks and 5 weeks (at protein level). Expressed in fetal liver
+Mostly expressed in photosynthetic tissues undergoing rapid growth. Observed in cotyledons and vascular tissues of hypocotyls of young seedling. In roots, restricted to apical and lateral meristems, and vascular bundles. In stems, mostly detected in the upper part. Expressed in young and middle-aged leaves. In flowers, confined to sepals
+Expressed both maternally and zygotically. Ubiquitously expressed throughout the development and in the adult
+Expressed in embryos from mid-gestation and in adult
+Transcript levels increase during rosette leaves development. In the inflorescence stem, highest levels in the young, developing tip and lowest levels in the basal stem tissues. Strong increase 4 days after fertilization. Specifically localized in developing seed coat (testa). Detected in the endothelium and in the pigment strand at the chalaza zone during early stages of embryo morphogenesis. Later, the activity increased and spread to the outer integument, mostly in the oil penultimate cell layer. Strongly expressed in early aborted seeds and in the transmitting tissue of the silique
+Highly expressed in the late stage of the last instar larval stage and the pre-pupal stage (PubMed:15813704). Detected at 4h into the last larval instar; however, expression levels are low during the feeding stage (PubMed:15813704). Levels increase from 16 h, reach a peak at 48h, quickly decrease just before puparium formation, and rise again after pupariation (PubMed:15813704). Highly expressed in midgut in the third instar larvae (PubMed:15813704)
+Is detected in unfertilized eggs, late planulae, and primary polyps, but not in adults (both males and females) (at protein level). At mRNA level, is found at multiple developmental stages including unfertilized eggs, blastulae, gastrulae, early planulae, planulae, metamorphosing planulae, primary polyps, juvenile polyps (low levels at 4 months old, but no mRNA at 2 months), adult males, and adult females, with the highest levels from gastrulae to primary polyps, and adult females
+At 4 days-post-fertilization (dpf), expressed strongly in the inner and outer plexiform layers and ganglion cell layer of the retina, in the tegmentum and in the hindbrain. Also expressed diffusely in the diencephalon
+In uterus during peri-implantation period strongly expressed in the luminal epithelium on day 1 of pregnancy and gradually decreased to a basal concentration from day 3 to day 5 of pregnancy. Strongly expressed in the implanting blastocyst and primary decidua on day 6 of pregnancy
+Expressed during the first 5 hrs of embryogenesis (at protein level) (PubMed:28875934). Expressed both maternally and zygotically throughout development (PubMed:2125288)
+First detected in the testis at postnatal day 10 and levels increase further and reach highest levels at day 40 and then gradually decrease
+Expressed at the time of acquisition of fusion competence of cells
+First expressed in embryonic hyp5 cells and then during larval development in pharyngeal muscles, uterine rings, head and tail neurons, sheath cells of chemo-sensory neurons, and in male neurons. Expressed in AC, vulval D rings and uterine seam cells in cell fusion events during development
+In anthers, expressed throughout the developmental stages, especially in the mature pollen grains. In pistils, expressed in the mature female gametophyte stage and during fertilization
+This protein seems to be found in adult B.jararaca venom but not in newborn snake venom
+Found in both the large cell variant (LCV) and small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs
+Expression was highest in embryos and neonates, peaking at 4 days of age in both calvaria and long bones and decreasing steadily with age to very low levels in 8-month-old long bones. The age-related decrease was less marked in calvaria by 8 months
+In developing eye expressed at embryonic days 12 dpc, 15 dpc and 18 dpc, and at postnatal days P1, P7, P14, and P21. Expression progressed from a more generalized distribution throughout the undifferentiated neural retina to specific staining of retina-pigmented epithilia, the MCs, photoreceptor cells and the ciliary apparatus. Expression is highest at P21. Isoform 1 and isoform 2 are expressed at equivalent levels at P7, isoform 1 is more abundant at P14, P21 and P28. In uterus during the peri-implantation period strongly expressed in luminal and glandular epithelium on day 1 of pregnancy and gradually decreased to a basal level from day 2-4 of pregnancy. Expression in the sub-luminal stroma was first detected on day 3 of pregnancy and increased on day 4 of pregnancy. On day 5 of pregnancy, the expression of basigin protein and mRNA was only detected in the implanting embryos, and the luminal epithelium and sub-luminal stroma surrounding the embryos. In ovary during sexual maturation expressed in the granulosa cells of preantral follicles at days 20 and 25 after birth. Expressed during corpus luteum formation
+Expression peaks in mitosis
+Expressed from 8 hours following initiation of development, prior to the appearance of mound tips. Subsequently persists throughout development
+Expressed both maternally and zygotically. Maternal levels decrease rapidly until the blastula stage. Absent from gastrula stage embryos and then zygotic expression starts during neurulation and persists until the end of organogenesis
+This histone is expressed during late embryonic development
+Expressed maternally and zygotically
+At all stages
+Synthesized 10-25 days after fertilization (developing endosperm)
+In germ cells, it is present at high levels in spermatogonia and spermatocytes until the pachytene stage, where it falls to undetectable levels. The transient drop at the pachytene stage coincides with the disappearance of the 5.2 kb mRNA and the accumulation of a larger 6.0 kb mRNA. Oocytes accumulate very large amounts of Dnmt1 protein during the growth phase
+Expressed at the root apex and at leaf primordia (PubMed:22323769). Accumulates specifically in hypocotyls in shade conditions (PubMed:27401556)
+First detected in gastrula. Prominently expressed in all neurogenic cephalic placodes and in lateral line primordia from neurula to tadpole stages. Weakly expressed in muscle later in development
+Expressed in the brain at 8.5 dpc, 9.5 dpc and 10.5 dpc
+Highest levels in hippocampus are found at postnatal day 3 prior to maximal synapse formation and decrease as synapse formation peaks in the postnatal period (at protein level)
+Expressed at early stage of flower development in the spikelet (rice flower) apical meristem and later in developing stamens, pistil primordia and differentiated anthers
+Loaded onto chromatin during DNA replication in a manner dependent on the initiation of DNA synthesis, and it dissociated from chromatin during mitosis. Chromatin loading is not induced by DNA double-strand breaks
+Expressed in embryos from the early heart stage and throughout embryogenesis (PubMed:18695688, PubMed:19066902). Induced at the onset of the maturation phase in the endosperm, in a high and homogeneous repartition (PubMed:18695688, PubMed:19066902, PubMed:25194028, PubMed:27681170)
+Expressed throughout development, with expression highest in the pupa
+During arbuscular mycorrhizal (AM) symbiosis with AM fungi, accumulates exclusively in cortical cells harboring arbuscules
+Is synthesized in microaerobic vegetative cells and pea bacteroids but not in aerobic vegetative cells
+Expression peaks at mitosis
+Broadly expressed from 7 dpc. At 10.5 dpc, strongly expressed in anterior ectoderm, pharyngeal arches, and distal part of the limb
+Expressed in E12.5 dorsal telencephalon in the developing cortex
+Highly expressed in the late exponential phase
+In neonates, expressed at low levels in striated and smooth muscles. As the animals mature sexually, expression increases 10-20-fold. Pregnancy promotes a 2-3-fold increase in expression in striated, vascular and uterine muscle (at protein level). Expressed in the prosencephalic neural folds at 8.5 dpc. Expressed in the lower urinary tract, specifically in epitheliumof the bladder, urethra, and genital tubercle at 13.5 dpc (PubMed:31883643)
+Expressed during embryogenesis and in adult kidney
+Expressed in gametocytes and gametes (at protein level); expression in stage II gametocytes is lower compared to stages IV/V gametocytes (PubMed:19642995). Expressed in ookinetes (at protein level) (PubMed:21949403)
+Expressed in embryo at 3.5 and from 7.5 to 10.5 dpc (at protein level)
+First expressed by 30 hours post-fertilization (hpf) along the tract of the anterior commissure, where it persisted until 48 hpf. Detected at 48 hpf in the preoptic area, ventral thalamus, and ventral midbrain and weakly in the ventral hindbrain. At 72 and 96 hpf, expressed throughout most of the brain except the dorsal forebrain. Expressed in the retinal ganglion cells
+First detected in kidney from 1 week old rats. Not detectable in fetal kidney and in kidney from newborn rats
+Mostly expressed during fruit development
+Induced one day after germination with a peak at day 5 and then declines steadily until day 8
+Expressed zygotically from stage 10.5. Expression is elevated between stages 12.5 and 14, and continues throughout neurulae, tailbud and swimming tadpole stages
+Expressed during the asexual blood stage, including rings, trophozoites, schizonts (at protein level) (PubMed:22355110, PubMed:29241041). Expressed in male and female gametocytes (at protein level) (PubMed:22355110). Expressed in sporozoites from the mosquito midgut, hemocoel, and salivary glands (at protein level) (PubMed:20584882)
+Expressed throughout development (PubMed:29769721, PubMed:29791857, PubMed:30728462). Following fertilization, in the zygotes and early embryos, it is expressed in the germline (PubMed:29791857). Evenly distributed in one-cell stage embryos (PubMed:29791857). In early embryos, segregates to germline precursor cells and is expressed in P1-P4 germline cells (PubMed:29791857, PubMed:29769721, PubMed:30728462). Also expressed in the endomesodermal (EMS) precursor cell (PubMed:29791857). Exclusively expressed in Z2 and Z3 larval cells at hatching (PubMed:29791857)
+Initial expression during neurulation. Increase during tailbud stages but decrease by the feeding tadpole stage
+Predominantly expressed during gastrulation. Expression first seen in early blastula stage
+Late stages of pollen development
+Detected in embryos from stage 15 onwards (at protein level). In first instar larvae, detected in midgut, Malpighian tubules and outer epithelial layer of the proventriculus (OELP) (at protein level)
+Expressed both maternally and zygotically. Expressed throughout development with highest levels at adult stages
+Expression is cell cycle-dependent with decreased levels in G2 phase; mediated by proteasomal degradation (at protein level) (PubMed:18354482). In aged individuals, increased expression in hippocampal CA1, CA3 and CA4 pyramidal neurons and in dentate granule cell neurons, but not in the cerebellum (PubMed:24670762)
+Expressed in fetal brain, heart, kidney, liver and lung
+Expressed during brain development. Expression drops in the adult
+Present at high levels in embryos on embryonic day 14 (14 dpc), in skeletal tissues on 18 dpc, and in adult brain. At lower levels in newborn rib cartilage, embryo soft tissues on 18 dpc, newborn skin and adult heart
+Detected as early as 10.5 dpc
+First detectable at 13.5 dpc in the male gonocytes, levels increase until about 16.5 dpc and then slightly decrease by 17.5 dpc (at protein level). Expression is maintained in all male gonocytes during embryogenesis, but becomes confined to a small population of the spermatogonia after birth
+At 14.5 dpc, in the developing limb, expressed only in the ectoderm and, in developing lungs, detected in the epithelium
+Is expressed more abundantly in juvenile than in adult vipers
+Differentially expressed in embryonic and adult tissues. Its abundance decreases from 10 dpc to birth
+Although dif-1 activity is required only during embryogenesis, it is expressed at all stages of development
+Present throughout fruit development
+Expressed during seed development
+Expressed on hemocytes/macrophages in embryogenesis (PubMed:8630729). First detected in late stage 11 embryos, which corresponds to the first wave of apoptosis (PubMed:8630729). Expressed in cells that by stage 12 spread throughout the embryo and by stage 13/14 have migrated from both ends towards the middle until they are evenly distributed by stage 15 (PubMed:8630729). In L3 instar larvae, expression increases with development in the gastric caeca, midgut, Garland cells and anterior testis (PubMed:21948708). In the ovary expression appears to be restricted to one pole (PubMed:21948708). Expressed in the ring gland, and weak expression in the salivary glands and the central nervous system (PubMed:21948708)
+Not expressed in the fetal lung, but is expressed at high levels 2 weeks after birth
+The peak periods of expression are: mid-embryogenesis, the second day of pupal development and in the adult
+Detected in retina at birth but not at prenatal stages
+Expression first detected in the lower neocortex at 18 dpc and decreases thereafter. At postnatal day 1, also expressed in the striatum and the olfactory bulb
+First expressed prior to the onset of gastrulation (early streak stage), then continues throughout embryonic development
+At 16 dpc, widely expressed with higher expression levels in non-neural cells and hippocampus. In the spinal cord, expressed as early as 12 dpc until p21, the expression levels decrease in the adulthood (at protein level)
+Probably maternally supplied, the zygotic expression is detected early during development at the 512-cell stage
+Expressed in trophoblast at 7.5 dpc and 9.5 dpc
+Expressed in commissural neurons in the developing spinal cord (PubMed:9639362). Expressed during the development of teeth and hair follicles (PubMed:26416033)
+Expressed in the brain at both embryonic and postnatal stages including the adult stage. The period of highest expression of the long isoform is at around two postnatal weeks, coinciding with the peak period of synaptogenesis
+Expressed maternally. Most abundant in eggs and expressed at a low level in blastulae, gastrulae, neurulae and tailbud embryonic stages
+Expressed in the developing OSNs at dpc 13.5 and 14.5 with reduced expression at dpc 16.5
+Strong expression was seen in 17-17.5 day-old embryos. Expression was also detected in the amnion of 17.5 day-old embryo
+initially expressed in the fetus (at protein level)
+Expressed during spermiogenesis, restricted to the postmeiotic phase of spermatogenesis. First detected in elongating spermatids tails during steps 9 and 10 and is prominent in this region during steps 11-16. Also weakly present in the cytoplasmic lobe of these spermatids. During the last steps of spermiogenesis (steps 17-19), it strongly diminishes in the tail but appears to increase or become concentrated in the shrinking cytoplasmic lobe. By the last step of spermiogenesis (late step 19), cytoplasmic localization is barely detectable in the resulting residual body but still detectable in the cytoplasmic droplet (at protein level). Detected in testis of pre-pubertal animals at very low level
+Bacteroid (nitrogen-fixing endosymbiont)
+In flowers, expressed in anthers, sepals, petals and peduncles. Accumulates during germination in embryos, reaching a maximum during the radicle emergence. In seedlings, restricted to the vasculature, with highest levels in the collar and the root. Later present in both elongation and root hair zones in roots. Also present in root cap columella. Detected before and during lateral root initiation and emergence and thereafter remained in vascular tissues of each lateral root
+Developmentally regulated in area CA1 of the hippocamus, peaking at around postnatal day 50 and declining thereafter
+Widely expressed in the nervous system at 18 dpc, with high expression in the posterior midbrain, which diminished toward the anterior midbrain
+Expressed in dry seeds. Increased expression throughout imbibition and germination and when radicle and shoots are emerging. Up-regulated during cell differentiation
+Expression first detected in brain and most anterior regions of spinal cord at embryonic stage 24 (26 hours). By stage 29 (35 hours) expression is also detected in posterior regions of spinal cord
+Expressed during most, if not all, stages of embryological development beginning in the morula and blastocyst and progressing through the yolk sac and fetal liver stages
+Expressed in developing caryopses from 1 to 5 days after flowering (DAF) and then declines to nearly undetectable levels by 15 DAF
+Expressed in embryos, larvae and adults
+Expressed in cotyledon and hypocotyls of germinating seeds
+Accumulates also in dark-grown seedlings
+Expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition
+Expressed at least from 7.6 until 17.5 dpc. At 7.5 dpc, expressed in the yolk sac, as well as in the parietal and visceral endoderm and the embryonic mesoderm. At 8 dpc, expressed in somites and head region. At 9.5 dpc, expressed throughout vasculature. At 11.5 dpc, primarily expressed in the intersomitic vasculature. At 17.5 dpc, predominant expression in heart and lung. At that stage, also expressed in brain, cochlea, tongue, cartilage, lung, liver and vertebrae. During hemangioblast differentiation, transiently expressed in hemogenic endothelium cells and down-regulated in nascent blood precursors. May be expressed during the precursor stage of myogenic differentiation
+At 8.5 dpc, expressed primarily in the anterior part of the neural tube. At 10.5 dpc, expressed in the neuroepithelium of the forebrain and hindbrain. At 11.5 dpc, detected in the neural tube, eye, limb buds and brachial arches. At 12.5 dpc, expressed in the hindlimbs and forelimbs, as well as in the forebrain. At 12.5 and 13.5 dpc, detected in single cells in the marginal zone of the developing cortex, as well as in other developing tissues and organs. At 13.5 dpc, expressed in the developing limb buds, in single cells in the mesenchyme surrounding future digit structures. At 15.5 dpc, detected in the inner root sheath of vibrissa hair follicle. Expression in the inner root sheath of the hair follicle continues later in life as it can also be detected in the back skin of newborn at postnatal day 3. At 16.5 dpc, expressed in the epithelium of olfactory and in the retina
+Expressed during embryogenesis
+In distal tip cells, expressed from mid-L2 when gonadal outgrowth initiates (PubMed:24613396). By mid-L3, just prior to the dorsal gonadal turn, levels drop dramatically (PubMed:24968003). In seam and hypodermal cells, levels are largely constant throughout larval development except for a transient peak early in L4 (PubMed:24613396)
+Expressed in early larval stages, in head hypodermal cells, head muscle cells, neurons, and ectodermal blast cells along the body (all P and all V cells) and in the tail (PubMed:29301976). Starting in the larval L2 stage, also expressed in P cell-derived ventral cord motor neurons (PubMed:29301976)
+Expressed during development; with a peak at 12 hours of development
+Expressed in embryos and adults
+Expressed both maternally and zygotically. Expressed at a low level in the mature oocyte, with expression increasing rapidly during gastrulation, and is maintained throughout organogenesis
+Expression is first detected in embryonic day 16 (16 dpc) brain, strongly increases at 20 dpc, and peaks within 24 hours of birth. The postnatal expression declines steadily to reach adult levels at P60
+Highly expressed in endothelial cells during embryonic vasculogenesis, and then down-regulated and restricted to specific endothelial cells. In the brain, expression is highest in regions that contain dividing and proliferating cells. As brain development progresses, expression restricts to the hippocampus and cerebellar cortex
+In roots, observed in the central cylinder (PubMed:24112720). Restricted to the petiole main vein (PubMed:24112720). Present in rosette leaves vascular system (PubMed:24112720). Expressed transiently during flower develoment in the anthers and developing siliques, mostly in the tapetal cell layer during pollen maturation (PubMed:24474628). Also observed in phloem cells of the flower stem (PubMed:24112720)
+Expressed in the embryo (at protein level) (PubMed:20549743). Expressed in the dorsal trunk of the trachea (at protein level) (PubMed:20549743). Isoform D: Expressed in the invaginating foregut (at protein level) (PubMed:20549743). Planar polarized during axis elongation from stage 7 (at protein level) (PubMed:24535826)
+In L3 instar larvae, expression increases with development. Expressed in the ring gland. Ubiquitously expressed in the testis whereas in the ovary expression appears to be restricted to one pole. Weak expression in the Garland cells, salivary glands and the central nervous system
+Increased expression during grain maturation and senescence. Not induced during flower development
+At 10.5 dpc, weak but widespread expression. By 12.5 dpc prominently expressed in the liver and also detected in developing CNS and dorsal root ganglia. At 14.5 dpc, expression is intensified in bone
+Expressed in non-migratory, syncytial epidermis at larval stage L1
+Present throughout the life of the leaf
+Ubiquitously expressed in blastocysts and 10.5 dpc embryos (PubMed:27476491). Expression increases during embryonic stem cell maintenance differentiation (PubMed:27476491)
+Becomes detectable in testis between postnatal days 15 and 21 and expression levels remain high in the adult. Not detected in fetal testis
+Expressed at high levels in embryonic tissue but is undetectable in somatic tissue
+Predominantly found in the prespores of the slug
+Uniformly expressed in the embryonic ectoderm but is transiently down-regulated during the initiation of wool follicle morphogenesis. Subsequently expressed throughout the epithelial component of the developing follicle except for a small group of cells at the leading edge of the follicle placode. In adult follicles, expressed throughout the outer root sheath but not in the inner root sheath or hair shaft, or in dermal cells associated with the follicle
+Detected in the egg cell and the central cell of the embryo sac (PubMed:14711878). After fertilization, it is expressed in the zygote (PubMed:14711878). After the first division of the zygote, it is detected exclusively in the basal daughter cell, while WOX2 is expressed in the apical daughter cell (PubMed:14711878). Through the 16-cell stage, it is expressed in all descendants of the basal daughter, the developing suspensor and the hypophyseal cell (PubMed:14711878). After the hypophysis had divided, expression stops in descendants, but remains present in the extra embryonic suspensor (PubMed:14711878). Moreover it is found in the cellularized endosperm of the micropylar region during the globular and heart stages of embryogenesis (PubMed:14711878). Not expressed later in embryogenesis or in postembryonic stages (PubMed:14711878). Activated in the zygote after fertilization (PubMed:21316593)
+Detected at highest levels in proestrus and estrus, with 10- to 12-fold increases over early diestrus
+Expressed in cells of the ABa lineage at the 24-cell stage of embryogenesis (at protein level)
+At 24 weeks of gestation, fragments of radial glial fibers are positive within the cortical plate and subplate of allocortical areas. These positive fragments often appear enlarged as varicosities and some of them terminate at blood vessels. Between 28 and 30 weeks of gestation, all iso- and allocortical areas contain immunolabeled radial glial fibers revealing curvature next to sulci. After 32 weeks of gestation, radial glial fibers gradually disappear; instead positive transitional stages between radial glia and astrocytes were found
+Maternally and zygotically expressed. Ubiquitously expressed during cleavage and blastula periods, and then it accumulates in the dorsal midline of the body trunk during gastrulation. During segmentation and pharyngula periods it is expressed in the neural tissue of the head region, and in the paraxial mesoderm of the body trunk. Subsequently expression diminishes until the hatching period, when it is expressed only in the cardiac sac and pectoral finbuds. Isoform 2 localizes in neural tissue in the head region, but not in the paraxial mesoderm in the body trunk
+In the developing aorta, expressed at low levels in 10-12 week old fetuses. Levels increase progressively in 24 week fetus, 6 month old child and 1.5 year old child aortic smooth muscle, reaching a maximum at maturity
+Expressed in embryos at high levels between 0-2 hours; from 8 to 14 hours, the highest levels are in the brain then diminishes to negligible levels (at protein level) (PubMed:22712556, PubMed:26022086, PubMed:29746464). Expressed in larval imaginal disks and salivary glands (at protein level) (PubMed:26022086). Detected in larvae at lower levels in imaginal disks, the central nervous system and ovary and, at extremely low levels, in testis (PubMed:26022086)
+Very low mRNA levels in the quiescent cells. As cells exit from G0 to G1 phase, the expression levels gradually increase
+Detected in hte testis during postnatal development at day 15. Restricted to the late-stage germline cells that line the seminiferous tubules
+In the embryo, expression begins at day 15.5
+Detected at 8.5 dpc in proliferating myoblasts of the dermomyotome and the developing heart tube. From dermomyotomal cells of the rostral somites expression progressed in a rostral to caudal pattern, with highest levels seen in the muscle primordia and mature muscles
+Expressed during all stages of development with highest expression in early embryo
+Isoform Oo is expressed both maternally and zygotically, being predominantly expressed in oocytes and embryos before the midblastula transition but present at later stages at very low levels. Isoform Em is expressed zygotically between late gastrula stage and late tailbud stage 30, being predominant during tailbud stages
+Late prestalk cell-specific expression
+Detected as early as day 71 of gestation. Expression increases consistently in lungs throughout the prenatal period. After birth, expression continues well into adulthood. At 71 days of gestation (pseudoglandular phase), expression is detected in tracheal and proximal conducting airway epithelium. Expression decreases gradually toward the distal airways. Strong expression in the epithelium lining the tips of the dichotomous and monopodial airway buds. Weakly expressed in smooth muscle cells around the large airways. Weakly expressed in mesenchymal cells and not at all in the mesenchymal cells surrounding the airway buds. Not detected in vessels associated with large airways (at protein level). At 94 days of gestation, similar expression pattern, but expression increases and extends toward distal airway epithelium. Strong expression in type II cells that line the primitive air spaces of late canalicular and early saccular phase. More prominent expression in the smooth muscle cells surrounding the large airways. Begins to be weakly expressed in endothelial and smooth muscle cells in large vessels, but not in small distal vessels (at protein level). At day 134 of gestation, further increase in expression in the distal airway epithelium. In large airways, predominantly expressed in the ciliated epithelium. Expressed at low levels in the mucus-secreting cells and at high levels in the submucosal gland cells. Weakly expressed in paracartilaginous cells, but not in cells in the extra-cartilaginous layer. Not detected in type I alveolar cells. Strongly expressed in endothelial and smooth muscle cells increased in large vessels and in distal vessels (at protein level). At birth, similar pattern of expression. Slightly decreased expression in the proximal airways (at protein level)
+Expression increases continuously throughout embryonic development. First detected in embryos at day 12
+Highly expressed in trophoblasts at 7.5 dpc, and in the maternally derived decidual tissues until 16 dpc. Expressed only at low levels in the embryo itself
+At 6.5 dpc, early and mid-streak stage embryos, was expressed in the anterior visceral endoderm. The expression domain extended from the extraembryonic-embryonic junction to approximately two thirds of the way down the epiblast. By the mid-streak to late streak stage, expressed in the anterior visceral endoderm but was also expressed in the definitive endoderm emanating from the anterior portion of the primitive streak. By the neural plate stage at 7.5 dpc expression was present throughout the anterior definitive endoderm layer including both the midline and anterior lateral endoderm. At the early headfold stage expression was reduced in the anterior lateral region and expression was seen primarily in the foregut endoderm. In early 8.5 dpc embryos, expression was restricted to the two most recently formed somites. In 9 dpc and 9.5 dpc embryos, expression continued in the two newest formed somites and also in the anterior presomitic mesoderm
+Accumulate in embryos and larvae, but not in adults
+Expressed early in the larval L3 stage, in both P6.px daughters and all four P6.pxx granddaughters following the first and second divisions of the vulval precursor cells (VPCs) (PubMed:31398431). After final VPC divisions, expressed in vulF and vulE cells (derived from P6.p) and persists into mid-L4 larval stage (PubMed:31398431, PubMed:17020758). Expression in vulF and vulE diminishes during mid-L4 so that by the transition to late L4, only uterine ventral (uv1) cell expression remains (PubMed:31398431, PubMed:17020758). Expression in uvl continues through the adult molt into adulthood (PubMed:31398431)
+Expressed in both bloodstream and procyclic stage parasites
+In juvenile fish, high level of expression in liver, intestine, kidney and muscle, and very low levels in heart, spleen and gill
+At 10.5 dpc, expressed in the whole brain, with the highest levels in the telencephalon
+First detected in the basal daughter cell of the zygote (PubMed:14711878). Unlike WOX2 and WOX8, it is not expressed in the egg cell or the zygote (PubMed:14711878). During two subsequent rounds of transverse cell divisions, it is restricted to the hypophysis (PubMed:14711878). At the 8-cell stage, it expands into the central domain of the embryo, in addition to weakening in the hypophysis (PubMed:14711878). After protoderm formation, expression in the central embryo domain is restricted to the protodermal cells and also disappears from the hypophyseal cell (PubMed:14711878). In subsequent stages, a ring of expression remains at the presumptive boundary between root and hypocotyl, at about the same position as WOX2 expression in heart stage embryos (PubMed:14711878). In addition to its embryonic expression, it is expressed postembryonically in the epidermal cells of the placenta during gynoecium development, but not in the developing ovules (PubMed:14711878). The placental expression disappears soon after fertilization (PubMed:14711878). Expression dynamics require MP and BDL, but not GN activity (PubMed:14711878). Detected as early as the first zygotic division in both the apical and the basal daughter cells (PubMed:17706632). By late globular to early transition stage, the protein is evenly distributed through out the embryo and the suspensor (PubMed:17706632). The basal half of the embryo, especially cells in the protoderm layer, starts to show slightly higher levels of expression by early heart stage (PubMed:17706632)
+Required for nitrogen fixation in root nodules on soybeans, but not for aerobic growth. It seems however to be expressed under many growth conditions (aerobic, microaerobic and in nodule bacteroids)
+Placental lactogen I is expressed in mid-pregnancy, while placental lactogen II is expressed throughout the later half of pregnancy
+Detected in the definitive endoderm from 7.5 dpc onwards (PubMed:17683524). Strongly expressed in the developing midgut by 9 dpc, but then at 9.5 dpc expression appears to decrease (PubMed:17683524). Global expression levels peak during 11 dpc: also detected at slightly lower levels during 7 dpc, 15 dpc and 17 dpc (PubMed:16990280)
+Expression first seen in late embryos. Levels are low during larval development and increase in late pupae to persist through to adulthood
+Expressed in oligodendrocyte-generating regions of the embryonic hindbrain
+First detected at low levels in the blastula stage and begins to accumulate in the margin of the blastoderm. At the shield stage, when gastrulation starts, expressed uniformly in the margin. As gastrulation proceeds, expressed at high levels in the posterior paraxial mesoderm. In the 1 day old embryo, at the early pharyngula stage, expression in the developing brain is very strong and expression is restricted to ventral domains of the brain. Expressed in endothelial cells of the intersegmantal vessels, between somite boundaries and in the dorsal aorta
+Embryonic pancreas and adrenal glands (at protein level)
+Expressed during development with a peak between 12 and 14 hours of development
+Nuclear prior to nuclear envelope breakdown. Localizes at the centrosomes in early prophase but in metaphase and anaphase, it localizes to the spindle poles In cells at late telophase undergoing cytokinesis it is detected at the midbody, a region of microtubule overlap (at protein level)
+Strong expression is detected in substantia nigra in brain and enteric nervous system in colon at P12. In colon sections at 12.5 dpc, 14.5 dpc, and P12, it is exclusively expressed in enteric nervous system (ENS). Also detected in dorsal root ganglion and spinal cord gray matter at 14.5 dpc
+Highly expressed in undifferentiated embryonic stem cells and expression is reduced after embryoid body (EB) formation. Not detectable at day 13 of EB formation; low levels are again detected at day 18 of EB formation
+It is present throughout the embryo. In the developing limb bud, the protein is expressed in the apical ectodermal ridge and the mesenchymal compartment, predominantly in the posterior region. During kidney morphogenesis, expression is initially restricted to the epithelial compartment of the pronephros and mesonephros. Isoform 5 is found in the apical ectodermal ridge and the mesenchymal compartment of the developing limb bud
+In the dorsal root ganglia, already detected at embryonic day 14, increasing until postnatal day 2 where the adult level is reached
+Strongly expressed in ventricular and subventricular zone progenitor cells of the neocortical wall at 12 weeks post-conception
+On embryonic day 15 (15 dpc) and 18 dpc, weakly expressed in the mantle zone throughout the neuraxis. On postnatal days 0 (P0) and P7, expression is evident in the cerebral neocortex, hippocampal pyramidal and dentate granule cell layers, olfactory granule, mitral cell layers and the striatum. A weak expression is seen in the gray matter of di-, mes- and met-encephalon and in the cerebellar Purkinje cells. On P14, expressed in the gray matter of the telencephalon such as the cerebral neocortex, olfactory bulb, hippocampus, dentate gyrus and striatum. On P21 and thereafter detected in the cerebellar granule cells
+Transiently expressed in the nascent hindlimb bud between Hamburger-Hamilton stages 15 and 19. Also found in the basal plate of rhombomeres 3 and 5, in pharyngeal and in foregut mesenchyme and in all facial primordia except for the mandibular arches
+Expressed throughout development. Levels may increase during the first 5 hours of starvation-induced differentiation
+Strongly expressed in meristemoids and at lower levels in guard mother cells (GMCs) and guard cells
+During forebrein development, it is expressed at higher levels in embryonic and early postnatal stages than in the adult forebrain
+Expressed zygotically from late blastula stage. Expression is barely detectable during tailbud stages and is absent by stage 35 (early tadpole)
+Isoform a: Expressed in dorso-ventral epidermal cells from the comma stage of embryonic development to adulthood. Isoform j: Expressed in the pharynx and head neurons from the 3-fold stage of embryonic development to adulthood. Isoform k: Expressed in dorso-ventral epidermal cells, the uterus, the vulva, the rectum and in head and tail neurons from the 3-fold stage of embryonic development to adulthood. Specifically expressed in seam cells at the 3-fold stage
+Expressed throughout development, highest expression in second larval instar and adult females
+Expressed in eggs, larvae, pupae, and male and female adults
+Expressed during seed germination
+Expressed zygotically. Expression begins after the midblastula transition (MBT) at the neurula stage
+Expression levels are high during embryonic development. Expressed within neuropil regions of the brain and ventral nerve cord in larval CNS and larval body-wall muscles (at protein level)
+Detected as early as 7 dpc and persist until, at least, 17 dpc
+At stage 8, detected in the cardiac crescent. At stage 10, expressed throughout the cardiac tube and the sinus venosus. By stage 15, expressed homogeneously in the various regions of the heart, including the atria, future left ventricle, bulbus cordis and truncus arteriosus, and in the forming branchial arches. Expression persists through stage 20, but decreases thereafter
+Expression starts 10-12 days after infection and continues during the lifetime of the nodule
+Expressed already by the time of neurulation. By 10.5 dpc, expression is abundant in the developing central and peripheral nervous systems. Major sites include the neuroepithelium of the fore-, mid-, and hindbrain, the spinal cord, the dorsal root, and cranial ganglia
+Strongly expressed in retina from embryonic stages 14.5 dpc to 17.5 dpc, where it is widely detected in retinal progenitor cells (at protein level) (PubMed:30146259). Expression then gradually declines and stabilizes at a low level by postnatal day 10 (P10) (at protein level) (PubMed:30146259). At P0, expression refines to the inner half of the neuroblastic layer (at protein level) (PubMed:30146259). Expression further refines to the retinal inner nuclear layer from stage P3 onwards (at protein level) (PubMed:30146259). Detected in bipolar OFF-type cells at stage P7 (at protein level) (PubMed:30146259). By stage P10, has only weak expression in bipolar OFF-type cells but strong expression in Muller glial cells (at protein level) (PubMed:30146259). Detected in brain at embryonic stages 12.5 dpc to 15.5 dpc, specifically in the ventricular zone and subventricular zone of the cortex (at protein level) (PubMed:19515908). Probably localizes to neural progenitor cells in the developing cortex (at protein level) (PubMed:19515908)
+Expressed soon after the initiation of development
+In the brain, expression increases after birth
+Expressed throughout development and in adults
+Expression is highest in the adult, lower in a 10 month old and very weak in an 8 week old
+Expressed in brain from 13 dpc to P0, and down-regulated after birth
+In testes, detected only when the elongated spermatids have differentiated from 96 days after birth
+Expression is detected in Rathke's pouch and overlying ventral diencephalon at carnegie stage 17 and in the anterior and posterior lobes of the pituitary at carnegie stage 20. At fetal stage, expression is observed in the anterior pituitary, and the ventricular zones of the hypothalamus and telencephalic vesicles
+Expression levels are relatively low in the mycelium. 53.9-fold higher expression level in the primordia than in the 20-day old mycelia
+Expressed in mature epididymis
+Expressed both maternally and throughout the zygotic stages, with highest expression at the bud stage. No evidence for a cyclic pattern of expression in the presomitic mesoderm during somitogenesis. Expressed weakly at the epiboly stage (4.5 hours) throughout the blastoderm. Expression clears from marginal region and localizes to the epiblast cells of the animal pole. As gastrulation proceeds, expressed in hypoblast cells that migrate towards the animal pole, in the prechordal plate and in forerunner cells. At 90% epiboly, expressed in the neural plate. At the three somite stage (11 hours), expressed in a small cluster of cells within the tailbud region and in future spinal cord. From the 8-14 somite stages, expressed in alternating pre-rhombomeres of the hindbrain, and more broadly in mid- and forebrain. Also expressed weakly in the anterior margins of the formed somites and in the anterior presomitic mesoderm. At the end of somitogenesis (22 hours), expressed strongly in the telencephalon and anterior midbrain, weakly in other parts of the midbrain and variably in the hindbrain
+Detected at high levels in several tissues including neural ectoderm, gut endoderm, somites, branchial arches, otic vesicles, limb buds and tail bud
+Expressed in embryos beginning at 8-12 hours, in first instar larvae, in pupae and in male and female adults with highest expression in early pupae (PubMed:11967260, PubMed:12530966). In epithelial cells, weakly expressed at late pupal stages with significantly elevated expression at the early adult stage of 0-4 hours after eclosion and levels returning to normal by 3 days after eclosion (PubMed:20412776)
+Exceptionally high levels found in the cortex and olfactory bulbs during perinatal development and are down-regulated during postnatal week 2. Expression in the cerebellar cortex is restricted to the granule cell layer of lobules 1-6. Anterior and posterior compartments become discernible only during postnatal weeks 2 and 6
+At 8.5 dpc, particularly enriched in the neuroepithelium, the forebrain and the somites. Highly expressed in the edges of the neural folds. By 10.5 dpc, detected in the brain, dorsal root ganglia (DRG), somites and limb buds. Highly expressed in the branchial and pharyngeal arches, neural crest-derived structures that give rise to portions of the face and neck. At 11 dpc, isoform 2, isoform 3 and isoform 5 are expressed in embryonic brain (at protein level). Expression of isoform 3 decreases steadily and becomes almost undetectable by 16 dpc, while expression of isoform 5 begins to increase from 13 dpc and peaks between 16 and 18 dpc (at protein level)
+Expressed during the asexual blood stage; expression starts in trophozoites and increases in schizonts and merozoites (at protein level)
+Expressed as early as 24 hours post fecondation (hpf), expressed at higher levels than leg1b
+At 14.5 dpc, expressed in the brain cortex, including the cortical plate, intermediate zone, and ventricular and subventricular zones
+Present at all stages, but reached the highest levels during early to mid-embryogenesis
+Detected throughout panicle development with the strongest expression in immature panicles, and weakest in mature panicles. Abundantly found in the stamen and carpel primordia of young spikelets
+Expressed throughout development, with the highest expression in mature siliques and during seed germination
+Expressed in the embryo and in early postnatal weeks. On and before P14, distributes in a homogeneous way, throughout the brain. By P21, high expression observed in the molecular layer of the cerebellum and in the olfactory bulb. The maximum expression and the adult pattern of distribution in the brain occurs by P30. By P30, P45 and P90, highest expression occurs in the molecular layer of the cerebellum and in the olfactory bulb, and relatively high expression in the hippocampus, cerebral cortex, thalamus and corpus striatum
+SpoIIIJ is required only after engulfment and turned off at the onset of sporulation. While it is predominantly expressed in vegetative cells, its low expression after the onset of sporulation is essential for sporulation to occur
+Initially ubiquitous expression at 12 hours post-fertilization (hpf), then strongly expressed in the central nervous system by 48 hpf (PubMed:28444311). Strongly expressed in the brain up to 5 days post-fertilization (dpf) (PubMed:28444311). Ongoing expression in whole brain tissue beyond 5 dpf into adulthood (PubMed:28444311)
+Expressed specifically in male and female archesporial cells and sporogenous cells (SC) before meiosis but not in the nursery cells supporting SC
+Expressed in larvae
+It is present but the disulfide bonds are reduced in the intracellular reticulate bodies (RBs)
+MLPs accumulate early in laticifer development and persist through maturity
+Expressed during embryo development and in dry seed. Expression decreases significantly after seed germination
+Expressed in fetal kidney and lung
+Expressed from 10.5 dpc
+During intrathymic development, transcript levels strongly increase from pro-DN1 thymocytes to DN3a cells, in which they peak, and drop immediately after beta-selection in their DN3b successors. The subcellular location of the protein also varies, from punctate cytoplasmic structures in DN1 and DN2 cells to large crescent-shaped membrane structures in DN3 cells, which preferentially localize in cell-to-cell contact zones
+There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I
+During male germ cell development it is not detected until 12 days. Significant expression is detected from 14-day-old through to adult testis. Expression is first detected in the pachytene spermatocytes at stage V, becomes stronger from the late pachytene spermatocytes to round spermatid stage, and then gradually decreases as the morphogenesis proceeds further. Not expressed in germ cells located in the first layer of the seminiferous epithelium (spermatogonia, leptotene and zygotene spermatocytes)
+Expressed in developing lung, kidney and central nervous system
+Expressed during embryo development and after the bolting stage, in mature culine leaves and in flowers. Not detected at the protein level at the rosette stage of development
+Expressed at late stages of spermatogenesis, from late to maturing spermatids
+Expressed both maternally and zygotically during embryonic development
+Expressed throughout embryonic, larval, pupal and adult stages, with increasing levels during larval development. Transcripts are first detected during embryonic stages 9-11
+Preferentially expressed in prespore cells
+Expressed during both vegetative growth and early stage of sporulation
+Highly expressed in fetal tissues. Expression markedly decreased in adult
+Maternally derived during fertilization. Expressed in the pericardium of the developing embryo and in the epidermal layer surrounding the digits
+In the embryo, expressed by day 12 of gestation. Maximum levels are found at day 30-40 followed by a rapid decline
+Isoform GPDH-2 and isoform GPDH-3 are expressed in both larvae and adults. Isoform GPDH-1 is expressed only in adults
+Undetectable during gastrulation and early phases of germ band formation. Increases during organogenesis, around 10 hours post-fertilization (hpf), to the adult stage
+Only secreted by caterpillars. Adult moth do not have spines
+Detected at embryonic day 18 dpc and at later stages. The expression does not significantly change during the developmental stages tested
+Expressed in fetal thymus
+Expression remains constant as development proceeds
+Detected throughout spermiogenesis, in round spermatids, elongated spermatids, and mature spermatozoa (PubMed:23054012, PubMed:20729278, PubMed:26940607). Detected at low levels on postnatal day 14, with significantly increased expression on postnatal day 16. Expression levels are unchanged after postnatal day 16 (PubMed:17927909, PubMed:20729278)
+At 8 dpc, strongly expressed in the node area (PubMed:27305836). May be up-regulated during progression from G1 to S phase of the cell cycle. Maximal expression in S or G2 phase
+Expressed early during germination and increases to a peak level when seedlings are established
+Expression in the testes starts 25 days after birth and continues thereafter
+Accumulates during flower development (at protein level)
+Expressed in the fetal kidney
+Present at low levels early in the fifth larval stadium, followed by a large increase in abundance prior to pupal ecdysis. Also present at low levels in adults
+Expressed in adult female
+Expressed early during pistil development
+Detected at low levels in embryonic brain. Expression is increased in newborns and during the first two weeks after birth. Expression decreases thereafter and is low after three weeks and in adult life
+High expression during growth and early development which drops precipitously during cell streaming at circa 8 hours of development
+First detected at 10 dpc, when it is expressed in progenitors of all three types of visceral musculature including in primordia of the circular midgut muscles, in foregut and hindgut visceral mesoderm primordia and in the caudal visceral mesoderm. At 10 dpc to 11 dpc, it is detected in nuclei of cells of the presumptive visceral mesoderm. At 12 dpc, expression persists in trunk and hindgut visceral mesoderm. By 14 dpc, expressed in both circular and longitudinal precursors of midgut muscles, and by 16 dpc, expressed in foregut, midgut and hindgut visceral muscles (at protein level). First detected at the embryonic syncytial blastoderm stage
+Constitutively expressed in all developmental stages, especially during the first 6-9 hours
+Late embryonic
+Expressed in the placental labyrinth from stage 8.5 dpc onwards
+In lung, up-regulated from postnatal day 3 (P3). Expression levels decrease after P5 and at P25, they are similar to those observed at P0 (PubMed:19273721). During the fracture healing process, expression is strongly up-regulated in the healing callus 14 days after the lesion and remains highly expressed at day 21 (PubMed:24586541)
+Embryos only
+First detected at 7.75 dpc in trophoblasts within extraembryonic membranes, in the lateral wings of the cardiac crescent and in the anterior head folds. At 8.0 dpc, it is expressed along the length of the linear heart tube and in the head folds. Expressed throughout the myocardium at 9.5 dpc and in the branchial arches. At 12.5 dpc, it is expressed in the heart and in the ventricular zone of the neural tube. At 13.5 dpc, it is weakly expressed in the intestinal epithelium. At 13.5 dpc and 15.5 dpc, it is also expressed in skeletal muscle, stratified epithelium (upper aerodigestive tract and skin), epithelium of developing airways, vibrissae, midbrain/hindbrain junction, meninges, mesenchymal cellular condensations that preceded cartilage formation and chondrocytes
+Expressed in heart, neural tube, limb buds and developing eye (PubMed:11335133). Earliest expression at embryonic 10.5 dpc in the heart, restricted to the endocardium that lines the atrial and ventricular myocardium (PubMed:11335133). Expressed in neural tube at 11.5-12.5 dpc, especially in the ventral regions, most likely in the motor neurons (PubMed:11335133). Expressed in fore and hindlimbs at 10.5-13.5 dpc (PubMed:11335133). Also expressed in area lining the lumen of the otic vesicle at 12 dpc and in the mammary gland primordium at 13.5 dpc (PubMed:11335133). Expressed in the marginal zone of the neural layer, and the central ganglion cell region, of the retina at 13.5 dpc (PubMed:11335133, PubMed:23172916). By 16.5 dpc, expressed in the developing retinal ganglion cell layer and optic nerve region; at postnatal day zero (P0), expression persists in the ganglion cell layer, and in the apical margin region of the retina (PubMed:23172916). By P7, expressed in a number of cells within the outer half of the inner nuclear layer and in the ganglion cell layer (PubMed:23172916). Transiently expressed in newly born photoreceptor cells at P0, but not in adult photoreceptor cells (PubMed:23172916)
+Mostly expressed in ovaries of flowers at stages S1 to S7 (bud to overblown), before the first disk florets opening, and prior embryos formation
+In EML cell line differentiation, expression increases 4 to 8 hours after treatment with all-trans retinoic acid (ATRA) and then declines after 24 hours of ATRA induction
+During embryonic development, expressed from mid-to-late gestation and in yolk sac
+Expressed during the vegetative growth phase, followed by marked decrease in response to cell differentiation induced by starvation
+Accumulates after eclosion and gradually increases during sexual maturation. In males, levels decline immediately after mating and recover progressively
+Expressed early in seed development and then declines gradually and disappears (at protein level). In the caryopse, strongly expressed during the pre-storage phase, and the expression decreased thereafter
+Observed in emerging secondary roots
+In the vegetative stage, first detected in the seed coat upon germination and in the hypocotyl of young seedlings. In seedlings, expressed in roots (mostly in primary roots), hypocotyl, rosette leaves and cotyledons. In rosette leaves, observed in the vascular tissue of major veins, guard cells and trichomes. During the reproductive stage, expressed in flower buds, stems, stamens, carpels and funiculi of siliques
+Expression is detected in the forebrain, midbrain/hindbrain boundary and neural tube. At the stage of limb bud outgrowth, expressed in a scattered manner in the ventral ectoderm, and is later confined to the apical ectodermal ridge (AER)
+Tends to mark the dorsal ectodermal and mesodermal cells. Initially expressed in the embryonic ectoderm and throughout the marginal zone from the late blastula to gastrula stages. Expression is restricted to the chordal and prechordal mesoderm by the neurula stages, and to certain cells of the cephalic neural crest at the tailbud stage
+G0-restricted expression
+Expressed from 3 weeks onwards
+At 8.75-9.75 dpc expression was detected in structures that include those destined to contribute to the cardiovascular system of the adult heart. Expression was also detected in the mesencephalon and rhombencephalon
+Expressed in most embryonic tissues except the heart from 8.5 to 11.5 dpc. Expressed in central nervous system (CNS, ventricular zone and spinal cord), peripheral nervous system (PNS, sensory cranial and spinal ganglia), olfactory and tongue epithelia, lung, gastrointestinal duct and urogenital system at 13.5 dpc. Expressed in CNS, thymus, various epithelial cell types including the olfactory, tooth and tongue epithelia at 15.5 dpc
+Expressed in mature flowers and not in young developing inflorescences or young floral buds
+Expressed from 11.5 dpc
+Expressed maternally in an animal to vegetal gradient, and later on was restricted to the animal region of the embryo. Expressed in the posterior paraxial mesoderm, adjacent to the notochord, from stages 13 to 24. Expression declined rapidly following gastrulation
+In flowers, strongly expressed in mature pollen and ovules
+At 7.5 dpc, expressed in the ventral node
+Expressed from early embryos to adults; maximal expression in third instar larvae through to adulthood
+Accumulates in well-developed arbuscule-containing cells during arbuscule development upon arbuscular mycorrhizal (AM) symbiosis
+Expressed in the apical meristem, the floral meristem, each whorl of organ primordia, and in ovule primordia during wild-type flower development
+Expressed throughout development; highest in embryos and at equal levels in males and females
+First detected in five-days seedlings. In seedlings, mostly present at the root tips and in the jointed section between the hypocotyl and root. In two-leaves seedlings, expressed in leaves, cotyledons and vascular bundles of hypocotyls, and very weakly, in the roots. In flowers, detected in sepals, filaments and pistil tips, but not in petals. Later accumulates in the jointed region between the silique and silique stem, and in the tips of siliques. Decreasing expression during seed development (PubMed:25014715)
+EMS has two different spatial patterns of expression during embryogenesis. The EMS head-specific expression pattern initiates prior to cellular blastoderm and continues only until early germ-band extension. The EMS metameric expression pattern initiates after gastrulation and is expressed in the lateral neuroblasts, in ectodermal cells at the anterior lateral borders of each segment, and in the Filzkoerper primordia
+Expressed during limb development, first in the mesenchyme of the early limb bud, then during early endochondral bone development in prehypertrophic chondrocytes of cartilaginous templates. Expression is also found in mesenchymal precursor cells and prehypertrophic chondrocytes, respectively, during development of skeletal elements of the vertebral column and the head
+Detectable in the female liver on day 1 and reaches steady state levels on days 16-20
+Adult levels are reached by day 25 after birth
+Appears on embryonic day 17 and gradually increases until day 19. Decreases between day 19 and birth
+Expression starts during embryonic gastrulation and persists through to adults (PubMed:11476572). Expressed in neuronal precursor cells during embryogenesis (PubMed:11476572). Upon hatching, expression is also seen in sheath/spermatheca precursor cells and later in gonadal sheath cells (PubMed:11476572). Expressed in head hypodermal cells (hyp3, hyp4, hyp5 and hyp6) in larvae (PubMed:11476572)
+Expressed in the developing germ line and throughout embryogenesis
+Expressed in stolons and increases during early stages of tuber development
+Expressed both maternally and zygotically. Zygotic expression is also seen in adult males
+Embryonic, larval and adult stages. First detected at 22 hours post-fertilization (hpf)
+Preferentially expressed in cells competent for DNA transformation; that is 5-15% of the population (PubMed:17630974)
+Detected in the theca layer of the ovarian follicle in the white follicle (WF) stage, but decreases throughout the F1, F3, F5, and postovulatory follicle stages. Detected in the granulosa layer of the ovarian follicle in the white follicle (WF) stage, F1, F3, F5, and postovulatory follicle stages. In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens
+Its levels are highest during the first day of embryonic development and then decrease; D7 protein was not detected in adult tissues
+Expressed both maternally and zygotically in embryos
+It appears in leaves 3 hours after induction, maximum levels are reached by 24 hours and remain at a high level over a period of at least 72 hours
+Expression is male-specific. Transcription begins in embryos between 2 and 2.5 hours after oviposition, before blastoderm formation, and expression and continues throughout the life of the mosquito. Expression precedes establishment of sex-specific splicing of dsx by up to 6 hours
+Expressed during somatic embryogenesis, especially in cells undergoing the first anatomical modifications leading to somatic embryo development. Accumulates also during zygotic embryo development. First detected at heart-shape-torpedo transition in the whole embryos. Developmentally regulated in cotyledons and hypocotyl, being restricted to the radicule in early and late torpedo, until the embryo reaches maturity. Gradual decrease at the seed coat during seed development. After fertilization, restricted to the seed coat and endosperm
+Accumulates in nucleus during the G1 phase of the cell cycle. During mitosis, the protein rapidly disappears, returning to daughter nuclei during G1
+Expressed in developing retinal progenitor cells at 12 dpc (PubMed:21875655). Has a segmental expression in the developing forebrain (PubMed:1676488)
+Expressed in somatic cells throughout development (at protein level) (PubMed:23263989). Isoform a: Predominantly expressed in embryos and adults (at protein level) (PubMed:23263989). Isoform c: Abundant at larval stages (at protein level) (PubMed:23263989)
+Expressed during embryonic development in the early and late gastrula stages, but not in the gastrulating blastula stage. Also expressed in the late trochophore stage
+Expressed in the egg chamber and more specifically in nurse cells (at protein level) (PubMed:17277377). Expressed during the first 2 hours of embryogenesis but is absent in 2-5 hour embryos (at protein level) (PubMed:28875934). Expressed both maternally and zygotically (PubMed:9118812). Expressed throughout embryogenesis (PubMed:22454519). In stage 2, uniformly distributed throughout the whole embryo (PubMed:22454519). During blastoderm formation, concentrated at the posterior pole to become incorporated into newly formed germ cells (PubMed:22454519). Subsequently accumulates specifically in the pole cells at stage 10, when they migrate through the posterior midgut primordium, and during stage 14, when the germ cells reach their final destination (PubMed:22454519)
+Present in the whole roots with a predominant expression in the proximal meristem, including the elongation zone, and a gradual decreases toward the differentiation zone
+Highly expressed in the pith and vascular bundle in the stem. Found in the pedicel of young buds. In siliques, mostly expressed in inner epidermis of the valve
+Expressed during unicellular vegetative growth
+During flower development, strongly expressed in pollen grains with a progressive increase from young buds to later stages of maturation (PubMed:28848569). To a lesser extent, present in the gynoecium, particularly in the style and carpel (PubMed:28848569). Also expressed in nectaries, petals, sepals and pollen tubes (PubMed:28848569). Accumulates progressively during seedlings development (PubMed:21969089). In mature plants, confined to floral clusters (PubMed:21969089). In roots, present in meristematic and elongation zones (PubMed:27913741)
+Expression peaks around day 15.5 of gestation. Expressed from day 6 to day 70 during postnatal testicular development
+Transcripts are present at 3.5 dpc in the somitic cells, which give rise to the dorsal dermis by 5 dpc, and at 6.5 dpc to 8.5 dpc in the dorsal dermal and epidermal cells during the first stages of feather morphogenesis
+Expressed in the ventricular zone of the brain at 28 hours post fertilization (hpf) and at lower levels, throughout the entire brain and in the posterior cardinal vein. Venous expression is maintained at 48 hpf. At the same time, there is also prominent notochord expression
+Present in reticulate bodies (RB) not detected in elementary bodies (EB) (at protein level) (PubMed:10447885). Found only in reticulate bodies in infected HeLa cells (PubMed:12694613)
+Expressed during development; with a peak of expression at 4 hours of development
+Induced during petal development and then decreases rapidly with maturation of the flower
+Highest expression in mid to late logarithmic growth phase, after which expression decreases slowly before leveling off in the stationary growth phase
+Isoform 1: Detected in embryos at the 4-cell stage. Not detected in embryos at the 2-cell stage, or at the 8-cell stage (at protein level). Detected in embryos at the 4-cell stage. Not detected in embryos at the 2-cell stage, or at the 8-cell stage (PubMed:28459457). Detected in induced pluripotent (iPS) cells, but expression is suppressed upon differentiation to embryoid bodies. Isoform 2: Detected in embryoid bodies derived from induced pluripotent (iPS) cells, but not in the induced pluripotent (iPS) cells themselves (PubMed:21060811)
+Not expressed in embryos. In young leaves, localized in transient patches along the vascular system. In young inflorescence stems, observed in vascular bundles of primary xylems. In maturing inflorescence stems, most pronounced in regions of developing interfascicular fibers
+In the optic lobe, first detected at embryonic day 14. Expression strongly increases between embryonic days 16 and 18, reaches a maximum at postnatal day 1, and then declines again to the adult level
+Expression begins between stage 30 and 35/36 in the heart and at stages 35-41 in skeletal muscles. Level of expression in the juvenile skeletal muscle is significantly lower compared to embryonic skeletal muscle
+Expression increases during the early stages of osteoblast differentiation, and decreases towards terminal osteoblast differentiation. In addition, expression markedly decreases during the course of osteoclastogenesis
+In cerebellum, expression begins at 12.5 dpc. In the developing retina, first expressed at 17 dpc in the ganglion cell layer. At P3, expressed in the inner border of the neuroblasitic border (presumptive amacrine cells). By P6, levels increase in developing cones. Expression found in the presumptive bipolar cells by P9. During adipocyte differentiation, expression gradually increases
+Expressed during the late third larval stage
+Expressed at the beginning of the adult stage, about four days after the pupal peak of ecdysteroids
+Isoform 1 expressed at low level in 13 dpc embryonic hippocampus, higher level by stage 15 persisting into juvenile and adult stages. Isoform 2 expressed in 13 dpc and 15 dpc embryonic hippocampus declining to very low levels in juvenile and adult neurons. High level of isoform 1 and very low level of isoform 2 in stage 2 and 5 hippocampal neurons in culture
+Expressed in prefusion carpel abaxial and adaxial epidermis. Accumulates in ovule primordia, but restricted to chalaza in mature ovules. Also present in cells of stigmatic papillae, at the margins of ovules, and around the embryo sac
+During seed development, expressed from 15 to 55 days after flowering (DAF), with a peak at 35 DAF
+Widely expressed throughout development. Low levels are found up to day 29 embryos. Levels increase from day 31 up until late gestation
+Expressed in embryos of different stages and young developing seedlings, but absent from mature seeds
+In roots, confined to the central cylinder (vascular tissue and pericycle) of both main and lateral roots. In leaves, expressed in the vasculature, mostly in phloem cells. Also present in the vasculature of stems and in stamen filaments of flowers. Detected at low levels in the vasculature of petals and carpels
+Expressed in embryos (maximal level between 5-12 hours) and at a low level in larvae
+Up-regulated during the differentiation of in vitro cultured cortical neurons
+Highly expressed in undifferentiated myoblasts and expression is reduced during the course of differentiation
+MER1 is synthesized only during meiosis
+Expressed in lateral endosperm after radicle emergence (72 hours germinated seeds). Expressed in fruit pericarp during the early stages of ripening
+Expressed in vegetative cells, increases about 5-fold during the first 2 hours of starvation and decreases rapidly during the subsequent 4 hours of starvation
+Preferentially expressed in cells competent for DNA transformation; that is 5-15% of the population (PubMed:11918817)
+Not detected until later in gestation
+Expressed during mid- and late-oogenesis
+Strongly expressed in developing ovules (PubMed:28500265). Expressed in embryos at the cotyledons, hypocotyls, procambiums, especially in epidermal cells and axis (PubMed:10363372, PubMed:28500265). Accumulates in imbibed pollen grains and in germinating pollen tubes (PubMed:29288621). Detected in embryo sacs (PubMed:29288621)
+Expression is initially maternally contributed, with increased expression at the two-cell stage followed by significant decrease at the 4-cell stage, remaining consistently low through to the morula stage (PubMed:20624068). Elevated expression in early embryonic stage (7 days post coitum (dpc)) with decreased but consistent expression thereafter in whole embryos (PubMed:10384051). Increased expression at 20 dpc in testis, with lower but consistent expression thereafter (PubMed:10384051)
+Expressed in embryonic brain
+Preferentially transcribed early during the life cycle
+Expressed predominantly in G2 phase
+First detected between 2 and 3 weeks after birth, in parallel with the onset and progression of meiosis. It is expressed during oogenesis from the pachytene stage of meiotic prophase through to postmeiotic cells. Expression in testis starts from postnatal day 7 (PND7) and expression remains constant until PND28 (PubMed:27492080)
+During the development of skeletal muscle, can only be detected 2 weeks after birth
+Production of the protein starts in day 2 to day 3 embryos and increases thereafter until hatching
+Ubiquitously expressed, from early embryogenesis to adulthood
+Expressed in the segmental plate and ventral mesoderm during early gastrulation and early somitogenesis (PubMed:25371059). Expressed in the marginal region and in a broad domain in the ventral region after 75% epiboly (PubMed:11703928). Expressed in the tailbud during the bud stage (PubMed:11703928)
+Appears in S phase, peaks in G2 phase, decreases in mitosis, lowest in early G1 phase and then accumulates again in late G1 and S phase (at protein level)
+Expressed predominantly in the developing neural structures. Levels gradually increases from 36 to 144 hpf
+Highly expressed in embryos
+Widely expressed throughout embryo development. Widespread expression in embryo until 12.5 days of gestation, after which it is then expressed in a more restricted fashion, with especially strong expression in developing lung, bone, and craniofacial region
+Expressed in the SCN during late fetal and early neonatal life. Expression increases during adipogenesis
+In the embryonic brain, expression begins at day 12 and continues until birth. Expression is maintained at low levels in adult brain
+Expressed in the left-right organizer and floor plate at embryonic stage 19 (ES19) (PubMed:31884020). Expressed in multiciliated cells of the larval epidermis and nephrostomes at ES33 and in dorsal lining of the branchial chamber and stomach at ES45 (PubMed:31884020)
+During the embryonic stages, high expressed in the brain, spinal cord, sensory ganglia (dorsal root and trigeminal ganglia), and thymus. In brain found throughout the ventricular and marginal zones
+Expressed zygotically from late blastula stage. Expressed at all subsequent stages from 10 (early gastrula) to 35 (early tadpole)
+Expressed in young developing stamen primordia and later confined to the central part of growing anthers. Before and during pollination, restricted to the maturing pollen grains
+Expressed during the primary developmental stages
+Developmentally regulated with levels peaking at culmination
+At stage 7 of embryonic development, expressed in the neural plate with lower expression in the midline. At stage 9, expression restricted to the dorsal neural tube and cranial neural crest. At stage 12, expressed in the lateral plate mesoderm. In the developing trunk, expressed, from stages 9-12, in the ventral migrating neural crest with some expression at stage 12 in the dorsal streams From stage 15, expressed in the endocardial cells of the outflow tract of the developing heart. From stage 18, expression found in the epibranchial placodes, in endocardial and mesenchymal cells of the developing atrioventricular canal and of the outflow tract cushions. Expression in these regions of the developing heart continue until stage 26. During limb development, low expression found, by stage 18, in the developing limb buds, By stage 20, highly expressed in the ventral mesenchyme of both fore- and hind-limb buds. By stage 24, expression localized to the central core of the developing limb bud, which contains the chondrogenic precursors. Also expressed in the surrounding nonchondrogenic mesenchyme. Later expression confined to the perichondrium and to the epiphyses of the early developing skeletal elements
+Expressed in radial glial cells, migrating postmitotic as well as postmigratory neurons of the embryonic cortex (PubMed:20093372). Expression is down-regulated in the ganglion cell layer and in the plexiform layer of the retina at P8 (PubMed:20093372). Isoform B: expression increases in regenirating liver (PubMed:23299899)
+Very high levels of CHS2 in cells undergoing hyphal outgrowth
+Expression increases gradually to a high level at pharyngula stage, which is restricted to the olfactory placode and the neural tube. In the juvenile zebrafish, the expression is first detected in undifferentiated gonad on 17 dpf
+Localized expression of in the posterior mesoderm (but not in the somites), and region-specific expression in the dorsal nerve cord, of amphioxus neurulae, later embryos and larvae. The anterior limit to expression in the nerve cord is at the level of the four/five somite boundary at the neurula stage, and stabilizes to just anterior to the first nerve cord pigment spot to form
+Abundant in embryos and pupae, rare in larvae and adults
+Expressed in the developing eye. In 48h embryos, low levels in the developing eye. High levels in the branchial arch region and within the nasal epithelium. branchial arch region and in the developing pancreas
+Very low levels found in the developing heart at 9.5 dpc when isoform 2 is the predominant isoform (PubMed:29374072, PubMed:32179481). Expression increases from 11.5 dpc and is the predominant isoform in adult heart (PubMed:29374072, PubMed:32179481)
+Barely detectable in bone marrow cells but levels progressively increase as cells differentiate into immature dendritic cells and are down-regulated after dendritic cell maturation (PubMed:23632887). Highly expressed in the developing heart at 9.5 dpc when isoform 1 levels are very low (PubMed:29374072). Levels increase up to 11.5 dpc and fall in the adult heart (PubMed:29374072)
+In somatic cells of the embryo, levels are dramatically reduced after the four-cell stage. In 1-day-old adult hermaphrodite gonads, levels are low in the distal gonad, dramatically increase as germ cells enter meiosis and remain high throughout the remainder of the gonad (at protein level)
+Detected at 17.5 dpc in brain (at protein level)
+During growth phase, peaking during at the early log phase
+DNA rearrangement occurs at the third hour of sporulation. Selectively expressed in the mother cell chamber of sporulating cells
+Expressed both maternally and zygotically. Zygotic expression begins just prior to gastrulation (stage 10) and gradually increases during subsequent embryonic stages
+Highly enriched in gametes
+Predominantly expressed in vegetative cells
+In flower buds, localized in filaments and stigmas. During embryogenesis, uniform expression from the globular embryo to the mature cotyledonary embryo. After germination, detected in whole cotyledons and in the hypocotyl. During the 6 first days after germination (DAG), highly expressed in roots throughout the elongation zone (EZ) and differentiation zone, but restricted to the endodermis and vasculature. Accumulates progressively in the quiescent center (QC). Down-regulated at sites of lateral root primordia (LRP) initiation. Absent at sites of deliberate wounding in the root. Mostly observed in the inner layers of the mature root, the QC and shoot apical meristem (SAM) (PubMed:24123341). Expressed early during endodermal differentiation, shortly after the onset of endodermal cells elongation (PubMed:25233277)
+Abundantly expressed through all stages of the life cycle
+Expressed both maternally and zygotically. Maternally expressed from early oogenesis. Zygotic expression occurs from late blastula and reaches maximum levels during gastrulation (stages 10.5-12). Levels decline at the time of blastopore closure (stage 13)
+Expressed during fruit ripening
+Present throughout cellular differentiation
+Not expressed in germinating pollen
+Expressed in the stages from 8-cell embryos to hatched blastocysts
+Abundant expression is seen in embryos and adults (PubMed:7907274). Expressed in embryos prior to elongation, at comma stage, at 1.5-fold stage and in adult gonad (PubMed:17021039)
+Expression is cell cycle-dependent, with highest levels in G2/M phase and lowest in G1
+In flowers, expressed exclusively in the pollen and growing pollen tubes (PubMed:27872247). During microspore development, confined to tricellular pollen (PubMed:27872247)
+Expressed in the ventral and dorsal parts of telencephalon at all developmental stages of brain analyzed (14 dpc to P56). Strong expression detected in the cranial connective tissue surrounding the brain at 14 dpc to 15 dpc. In the cortex, expressed mainly in the marginal zone at preplate stage (14 dpc), with expression increasing strongly in the marginal zone/layer I between 15 dpc and 18 dpc and declining rapidly in layer I after P0. Expression emerges in the lateral part of cortical plate at 15 dpc and increases in the medial and lateral parts between 15 dpc and 17 dpc. Expression not detected in the cortical ventricular and subventricular zones at the early embryonic stages but emerges at 18 dpc. Expressed in GABAergic precursors and in some reelin-expressing Cajal-Ratzius cells, in neurons forming the cortical plate and sparsely in the developing dentate gyrus and cerebellar external germinal layer. In the ventral telencephalon, expressed in the germinative zone of the ganglionic eminences and in GABAergic neurons forming the caudate putamen between 14 dpc and 18 dpc
+Expressed at low level during embryogenesis. Highly expressed after birth
+Mainly expressed in dividing cells such as primary roots of seedlings (within the meristematic zone but not in the differentiation zone), lateral roots primordia, developiong leaves and shoot apices
+Expressed in muscle and brain at 14 dpc (at protein level). Expressed in embryo at 7.5 dpc
+Expressed in larvae, pupae and female adults (at protein Level)
+Present at low level in male gonads in postnatal day 7 (P7) Expressed at higher level in P14, P21 and adult testes, correlating with the onset of meiosis (at protein level). Expressed in spermatogonia, spermatocytes and round spermatids, but not in elongating spermatids
+Periodic expression during the cell cycle with a peak at S phase
+Highly expressed in embryos and at lower levels in larvae, pupae and adults
+Expressed first during gastrulation and later in a dynamic pattern in the central nervous system
+Expressed in germinating seedlings and senescing leaves
+Expressed at low levels in growing cells, but at high levels in the prestalk-cell region during the developmental phase
+Expressed constantly throughout brain development, with lower levels in adulthood
+Ubiquitous in young leaves. Later, restricted to the leaf base in the trichome initiation zone. In mature leaves, confined to trichome cells
+Expressed by prestalk cells
+At 8 dpc no significant expression of mRNA or protein is observed, but strong signals are observed in placental trophoblasts. By 11 dpc weak positive signals are observed in heart. During later stages of development, stronger expression is observed in a variety of tissues, particularly in the atrial and ventricular walls of the developing heart, spinal root neural fibers and skin
+Detected from early embryogenesis onwards (stages 11-35) (PubMed:24044555, PubMed:28104388). Expressed in the mesoderm during gastrulation (PubMed:24044555). Expressed in migrating neural crest cells, where it partially colocalizes with twist1 (PubMed:28104388). As development proceeds, shows marked expression in developing anterior structures including brain, pharyngeal arches, eye (including retina and lens), otic vesicle, heart, pronephros, liver and cranial ganglia (PubMed:24044555, PubMed:28104388)
+In the 7-day-old testis, isoform beta is expressed at significantly higher levels than isoform alpha. As development proceeds, the levels of isoform alpha gradually increase so that it is the predominant isoform in mature testes
+Expressed during metamorphosis in pupae
+Expressed in the developing retina (at protein level). First expressed at 6.5 dpc of embryo development around the anterior border. At 8.5 dpc, expression is found over the anterior neural plate. At 9.5 dpc, in the diencephalic part of the ventral forebrain, optic vesicles, olfactory placodes and Rathke pouch. In later stages, present in hypothalamus, eyes and pituitary. Expression at around 7.5 dpc to 8 dpc is high in the anterior neural ectoderm. Weaker expression is detected in the prechordal plate. At the 5 somite stage (8.0 dpc), expression is maintained in the anterior neural ectoderm. Around the 8 somite stage (8.0 dpc), expression is already restricted to the ventral forebrain and eye field. At the 12 somite stage (8.5 dpc), expression is maintained in the ventral forebrain (PubMed:18694563). At 9.5 dpc strongly expressed throughout the prospective nasal ectoderm. At 10.5 dpc remains expressed throughout the nasal ectoderm (PubMed:16024294). At 7.5 dpc expression is found in the developing anterior neuroectoderm. At 9.0 dpc expression is found in the region of the presumptive lens ectoderm and developing optic vesicle. At 9.5 dpc expression is found in the lens placode, optic vesicles, and ventral forebrain (PubMed:11458394)
+Expressed throughout development. Expression levels are very weak, but increase in the adult stages
+During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells
+Much more expressed in adults than in larvae
+Present at all stages. Levels increase from L1 to adult stages
+Highly expressed in metastatic cells
+Expressed transiently in early stages of floral meristems development but continuously in axillary shoot meristems, specifically in the dorsal part (adaxial)
+Detected at neurula and tadpole stage
+It is synthesized during oogenesis and persists in the cleaving embryo at approximately constant levels until it is degraded just before gastrulation
+At 13.5 dpc expressed in epaxial, intercostal, and other skeletal muscles at the brachial level, including the latissimus dorsi muscle. Expressed in the intrinsic and extrinsic muscle mass of the tongue. At 15 dpc expressed in mesenchymal tissue surrounding the cartilaginous anlage of immature bones, and in the future joint spaces. As endochondral ossification progresses, and the hypertrophic cartilage zone is replaced by mineralized bone, expression appears in the mineralizing portion of the bone. Expressed in mesoderm derived bones of the skull base and neural crest-derived endochondral bones such as the proximal mandible
+Is expressed throughout embryonic, larval, pupal and adult stages at relatively constant levels
+Expression peaks in the first larval instar, midpupal, and late pupal stages. In late-stage embryos, it is expressed preferentially in the nervous system
+Expression peaks between 2.5 and 5 hours of development
+Levels relative to total cellular protein, increase as differentiation proceeds towards the final culminant. The levels of tri-methylation of Lys-5 (H3K4me3) diminish considerably during the process of differentiation. In contrast, the level of mono-methylation of Lys-5 (H3K4me1) becomes significantly enhanced during differentiation. There is a slight dip in di-methylation of Lys-5 (H3K4me2) around the time of aggregation and the level of this mark again dips during the final stages of spore formation. The levels of H3K4me1 and H3K4me2 rise during the inactivation of rasG that occurs after the onset of differentiation. The level of dimethylation at this locus peaks coinciding with the loss of H3K4me3. This enrichment of dimethyl H3K4 declines as the rise in the level of H3K4me1 continues. H3K79me2 (di-methylation of Lys-83) is expressed during the whole life cycle
+Expressed in larval and adult stages
+Not found in embryos. Higher levels in tissues undergoing primary cell wall formation, and drop of expression when secondary wall synthesis takes place. High levels in developing seedlings and elongating stems, with a decrease at later growth stages
+Expressed in the growing regions of roots, coleoptiles, internodes, and leaves
+In flower buds, localized in pollen grains and the separation layer between the bud and the peduncle. During embryogenesis, uniform expression from the globular embryo to the mature cotyledonary embryo, except in the embryo suspensor. After germination, detected in whole cotyledons and in the hypocotyl. Detected in the aerial tissue of 1-3-day-old seedlings, and in the root epidermis and lateral root cap cells. Within the epidermis, mostly expressed in H cells during the first three days after germination (DAG) and becomes restricted to these H cells in mature roots. In the root apical meristem (RAM), mostly confined to the quiescent center (QC) by six DAG. Mostly observed in the outer layers of the mature root and the RAM, including the QC (PubMed:24123341)
+Highly expressed in the early globular stage embryo before 2 days after pollination (DAP), but not in the endosperm. At 3 and 4 DAP, expression is restricted to the region around or just below the center of the ventral side of the embryo, where the shoot apex subsequently arises. During the transition to the shoot apex differentiation stage, expression is divided between the upper and basal regions of the shoot area, and the notch between the first leaf primordium and epiblast, respectively. When the first leaf primordia is evident, expression is localized to the notches between the shoot apical meristem (SAM) and the first leaf primordium and the putative second leaf primordium. Expressed uniformly in the inflorescence meristem, but after the transition from inflorescence to the floral phase, located specifically in the notches between the floral meristem and glume primordia. At later stages of flower development, uniformly expressed throughout the corpus of the meristem, and in the notches between glume primordia, but less well defined than in the previous stage
+In embryogenesis, expressed from stage 11 at the posterior tip of the germ-band; during germline retraction, expressed both ventrally and dorsally; expressed in the developing fat body and lymph nodes. In larvae, expressed in the fat body and in mature hemocytes with weak expression in the lymph glands
+Expressed in the developing septum, transmitting tract and stigma
+Strongly expressed in 8.5 and 12.5 dpc
+Expressed before day 7 in the embryo and reached its highest levels at 10.5-11.5 days. In the embryo at day 11, expression is more specific in the roof of the hind brain and the lateral ventricle of the brain
+Expressed in the embryonic neural tube, brain, pectoral fins and the pronephric glomerulus (at protein level)
+Highest level only in mature worms, i.e. during egg production
+In queens, first expressed in mid-late pupal stage and a high production is maintained throughout adult life. In workers, observed in late pupal stage and expressed at low levels in adults. Levels can increase in some young workers if an egg-laying queen is missing to the colony. Also detected in drones, but in freshly molted adults and not in pupae
+Expressed in all developmental stages
+Expressed in the embryo proper at the globular stage. Expressed in the embryo until the torpedo stage, after which expression within the procambial strands becomes pronounced
+In the larva, expressed mainly by fat body adipocytes and blood cells and secreted in the basal membranes that surround the fat body, imaginal disks, tracheae, salivary glands, midgut, mature muscles and heart (at protein level)
+In the ovary appears at 13.5 dpc and disappears shortly after. In postnatal testes, expression increases between 5 and 10 dpp and is maintained through adulthood. In male and female germal cells present from preleptotene to diplotene stages of meiosis prophase I
+Ubiquitously expressed throughout development and in adults
+Expressed early during development. Detected in all fetal tissues tested
+Up-regulated in leaves during natural senescence
+Expressed in salivary glands (at protein level)
+In young seedlings, mainly observed in the vascular cylinder of cotyledons, leaves and hypocotyls. Accumulates also in root tips, lateral root initiation sites and the maturation zone of the primary root. In adult plants, present in the vasculature of the inflorescence stems, especially in phloem cells
+Peak of expression during cotyledon development
+Expressed in the developing retina and epithelial cells of the lens at 12.5 dpc. Expressed in the developing cerebral cortex at 15.5 dpc
+Expressed in the retinal ganglion cells (RGC) during retinogenesis (PubMed:21046643). Expression is not detected in the retina before 36 hours post fertilization (hpf) but is highly expressed at 48 hpf during later stages of RGC neurogenesis (PubMed:21046643)
+Expressed at low levels during larval stages, and at higher levels in pupae and adults (at protein level). Ubiquitously expressed in the wing disk (at protein level)
+Expression peaks at early stages of development at the time cells become highly chemotactic and aggregation competent
+Highly expressed after birth, expression decreases 2 weeks after birth and is maintained until, at least, 18 months
+High extraembryonic expression is detected at 7.5 dpc in the maternally derived deciduum. Also detected along the yolk sac vessels during the process of remodeling at 9.5-10.0 dpc. Within the embryo, detected at 7.5 dpc in the lateral mesoderm including the precardiac mesoderm. On day 8.5 pc expressed throughout the straight heart tube. In the caudal region of the embryo, expressed in the lateral mesoderm at the level of separation of the somatic and splanchnic mesoderm. On day 9.5 pc expressed throughout the developing cardiovascular region, most abundant in the outflow tract and in the first and second aortic arch arteries, and in pharyngeal arches. As the heart loops, the expression becomes restricted to the conotruncus and future right ventricle (endocardium and myocardium). At 10.5 dpc, highly expressed in the branchial arches, as well as in the truncus arteriosus, aortic sac, and the vascular mesenchyme between the third and fourth aortic arch arteries, which later gives rise to vascular smooth muscle cells and to the mesenchyme of the pharyngeal arch. At 13.5 dpc, barely detectable in the heart, but apparent in the neural crest-derived sympathetic trunk and adrenal medulla, a pattern similar to that of HAND1. In the developing limbs, expression is detected in the posterior mesoderm of the buds at 9.5 dpc. It is then progressively down-regulated at the anterior of the limb buds so that a gradient expression along the anterior-posterior axis of the bud is established with higher expression at the posterior border. At later stages of limb development, expression is restricted to the posterior border of the zeugopod and to the posterior autopod. In the autopod, dynamic expression of HAND2 affects the interdigital regions, the lateral borders of the digits and eventually the developing ventral tendons. After 16 dpc, expression decreases throughout the embryo
+In embryonic skeletal muscle, significantly increased levels between 13.5 dpc and 15.5 dpc with maximal expression observed at 15.5 dpc (PubMed:23233679). Decreased levels in postnatal skeletal muscle (PubMed:23233679). In myoblasts, up-regulated soon after induction of myoblast differentiation (PubMed:23233679)
+Faintly expressed during development
+GPR transcription occurs during sporulation in forespore first by sigma-F and then by sigma-G
+Expression increases in the ovary during the meiosis prophase I period at 55-65 dpc and decreases until the end of the fetal life and then remains very low in adult ovary. Low expression in testis throughout fetal development
+Expressed at all stages, however, the highest level appears in mycelia, followed by germinating spores, and the lowest in spores
+Expressed during embryogenesis and adulthood (at protein level) (PubMed:18794349). Expressed in most cells starting at gastrulation and diminishing by the L1 larval stage; however, also expressed in L4 larval stage and adults (PubMed:18794349)
+Early limb development. First present in an asymmetric arc extending from the anterior border of the limb bud to the mesenchymal cells directly adjacent to the AER. Later abundantly expressed in the proximal anterior periphery and in the mid-proximal region of the posterior periphery. In older wing buds, detectable throughout the necrotic mesenchyme between the developing digits
+Expressed in the renal pelvis and ureter smooth muscle layer at 17.5 dpc (at protein level) (PubMed:26235987). During development expression is most prominent in the proepicardial organ and in the epicardium. Expressed also in the cranial paraxial mesoderm, the presomitic mesoderm, the anterior somite half, the genital ridge and the developing limb buds (PubMed:11118889)
+Finds at the highest levels in 7 dpc, then progressively lower at 11 dpc and 15 dpc, and finally very diminished at the 17 dpc
+Strong expression in the brain barriers and many subpopulations of neurons, including cortical and cerebellar neurons at postnatal day 6. Decrease expression in neurons upon aging, whereas expression in the blood-brain barrier and blood-cerebrospinal fluid barrier do not change upon aging (at protein level)
+Expressed at moderate levels during growth and development
+All stages of development
+Expressed in newborn snails as well as adults
+In synapses, is expressed at embryonic day 15 and colocalizes with acetyl-choline receptor at prenatal day 4. Expression decreases in adult
+Highest level in brain of sixth larval stage. Similar levels in adult male brain. Lower levels in adult female and early pupal brain. Lowest levels in prepupal and 10 day old pupal brain
+Zygotic expression begins after gastrulation at stage 12.5
+Expressed only at embryonic stages. Present at 12 dpc in primordial lung, cartilage and otic capsule (at protein level)
+Expressed in developing tissues and at high levels in adult tissues. Isoform A shows male-specific expression
+Embryonic and adult stages (PubMed:8000074, PubMed:16556608, PubMed:16676361). Also detected in larvae (PubMed:16556608)
+Esoxpressed in source leaves and sink leaves
+Initially, the transcripts are localized to notochord, somites, and the dorsal region of the lateral plate mesoderm. At later stages of development and parallel to increased mRNA accumulation, collagen expression becomes progressively more confined to chondrogenic regions of the tadpole
+Expressed from stage 13 of embryonic development in a small number of cells in the central nervous system and in a subset of neurons of the peripheral nervous system. Such cells may include sensory precursors of multidendritic (md) neurons. At embryonic stage 16, prior to when dendritic process are elaborated, it appears to be expressed in multidendritic neurons in a polarized manner. At stage 17 of development, when the md neurons first initiate dendritogenesis, it is localized to branched projections initiating from clusters of multidendritic neurons
+Expression is first detected at 16.6-17.5 dpc
+Widely expressed in the embryo. After 60 hours post-fertilization there is increased expression in heart, liver, branchial arches, exocrine pancreas and intestine
+Expressed throughout both the four and the fifth larval instars
+At embryonic day (E) 13.5, expressed in the cortical preplate and cingulate cortex. By 15.5 dpc, the strongest expression is seen in the cortical plate. By 18.5 dpc, cortical expression is most intense in the upper layers and subplate. There is strong expression in the areas CA1-3 of the hippocampus. At P0, cortical expression is strongest in the dense cortical plate and subplate. Hippocampal expression is more intense in areas CA1-3 than in the dentate gyrus. At P8, lamination is almost complete and cortical expression is strongest in layers II-III and V and the subplate. There is also expression in the mediodorsal nuclei of the thalamus, the mitral cell layer of the olfactory bulb, and the external granular layer, molecular layer, and internal granular cell layer of the cerebellum
+Expressed maternally and zygotically in embryos
+Expressed in fat body of last instar larvae
+Expression begins at the 2-fold embryonic stage and continues throughout the larval stages (at protein level) (PubMed:10854422). During the early stages of larval development, specifically expressed in the intestinal cells with the highest levels in the posterior intestinal cells int7 and int8 (PubMed:10854422). Not expressed in adults (PubMed:10854422)
+Progressively accumulates in fruits when berries are white and full size until complete ripening
+Expressed as early as 13.5 dpc, increases and peaks at 2 weeks after birth and is highly expressed until adulthood
+Expression increases during fruit development but decreases during ripening
+Expressed early in seed development with a peak at 6 days after pollination (DAP) and then decreases slightly (at protein level). In the caryopse, slightly expressed during the pre-storage phase and was strongly expressed from the early to middle storage phase
+Levels of AS increase markedly after harvest
+Expression is much higher in the stomach and jejunum in young mice compared with adult mice
+Expressed in the forespore compartment of the developing sporangium
+Expression decreases in developing seeds and increases during seed germination
+At 48 hours post-fertilization (hpf), it is highly expressed in the CNS, particularly in the brain tissues. The pattern is the same at 72 hpf
+Expression is cell cycle-dependent, with highest levels in G2/M phase and a drastic drop in S phase (PubMed:22801543, PubMed:23913683). This trough may be mediated by DCX(DTL) E3 ubiquitin ligase complex (also called CRL4(CDT2))-mediated proteasomal degradation (PubMed:23913683)
+First detected in the kinocilia of vestibular and auditory hair cells at embryonic days 14.5, and 18.5, respectively. In the mature vestibular hair cells, it is still present in the kinocilium. As the auditory hair cells begin to lose the kinocilium during postnatal development, it becomes distributed in an annular pattern at the apex of these cells, where it colocalizes with the tubulin belt. In mature auditory hair cells, it is also present at the level of the cuticular plate, at the base of each stereocilium. As the kinocilium regresses from developing auditory hair cells, it begins to be expressed by the pillar cells and Deiters cells, that both contain prominent transcellular and apical bundles of microtubules. Not detected in the supporting cells in the vestibular end organs (at protein level)
+Maximal levels are seen in 4-day old seedlings and decline during aging of the seedling
+One of the proteins expressed by the 44D cuticle gene cluster. Expressed in first, second and early 3rd instar larvae and in adults, but not in embryos or pupae
+Developing ovules and young seeds
+Expressed from 10.5 dpc to 14 dpc in developing liver and then decreases. It increases again from 17.5 dpc and remains thereafter. Highly expressed in hematopoietic embryonic tissues from 10.5 dpc to 14.5 dpc. Weakly expressed in the yolk-sac
+During arbuscular mycorrhizal (AM) symbiosis with (AM) fungi (e.g. Glomus intraradices), accumulates mostly in root cortex cells containing arbuscules
+Isoforms b and d are widely expressed from embryogenesis to adulthood. Isoform d is highly expressed in late L1 and L2 larval stages in XXX neuroendocrine cells. Isoform b is expressed more highly in the embryo and the L1 larval stage
+Expressed in the spinal cord from 11 dpc to the adult stage (PubMed:8290353). As early as 10.5 dpc to 15.5 dpc, strongly expressed in all dorsal root ganglion neurons (PubMed:22326227). In retinal ganglion cells, expression starts at 15.5 dpc and exhibits a slow decrease with moderate levels detectable at P8 (PubMed:8637595)
+First detected in the thymus during day 4 of development. Expression then increases in the thymus for at least three weeks
+Expressed from late embryogenesis onwards but mainly expressed at young adult and adult stages
+Expressed in the MS, C and D embryonic lineages, which develop into somatic gonadal precursor cells (SGPs), other mesodermal cells and bodywall muscle (PubMed:12756172). Expression is abolished in most body muscle cells by the comma stage of embryogenesis, but continues in the SGPs (Z1 and Z4), and then is abolished shortly after assembly of the gonadal primordium (PubMed:12756172)
+At 17.5 dpc, highly expressed in the cortical plate and in the subplate (SP)
+Expressed from the comma stage of embryogenesis, during all larval stages, and in adults
+Not detected in senescing leaves
+Highly expressed in oocysts and schizonts (PubMed:33711786). Expression is low during the blood asexual stage and in mosquito salivary gland sporozoites (PubMed:33711786). Expression is low at the host liver stage; however, expression increases at the late stage (PubMed:33711786)
+Expression in testis begins with developmental differentiation of pachytene spermatocytes
+Expressed in the placenta throughout pregnancy
+Expressed in forebrain at 16 dpc
+Expressed from embryo day 10.5 to birth. At day 10-13, expression in somites and the ventral horns of the spinal chord. At day 13.5, strongly expressed in the corpus striatum. At day 16.5, expression also in the pituitary with weaker expression in the neck, skeletal muscle and tongue. Expression in the corpus striatum continues until at least 7 days after birth
+Expressed in neural crest at all developmental stages, and in developing somite and myotome
+Expressed at M-phase onset and accumulates at microtubule minus ends
+Expressed both maternally and zygotically during embryogenesis
+Expressed during all stages of embryogenesis
+Expressed late in development. Isoform Long is expressed in vegetative cells and at all stages of development. Isoform Short is just observed in WT cells, at late developmental stages
+Expressed during anther development in tapetal cells and microsporocytes during meiosis. When the tapetum degenerates, detected only in pollen grains
+Expression peaks before the end of gastrulation and drops down by 24 hours post-fertilization, when the heart starts beating (PubMed:27411634). Expression precedes that of the earliest endothelial and haematopoietic markers etv2 and tal1 (PubMed:27411634)
+Expressed during aggregation, reaching a peak at 12-16 hours. Accumulates in prestalk cells and, to a lesser extent, in prespore cells as well
+Expressed in germinating seeds and in very young seedlings. Declines to low levels during later stages of development
+Slightly expressed in seedling leaves
+First expressed at a low level in stage II oocytes. Expression increases dramatically from oocyte stages III to V (at protein level). Also expressed in embryos
+Expressed at early stages of nodule development
+Expressed in head mesenchyme, somitic mesoderm and notochord at stages 8 and 9. Expressed in the presumptive otic vesicles at stage 9. Expressed in the somites, the entire notochord and the otic epithelium at stage 9. In the developing inner ear, expressed in the entire elongating endolymphatic duct and sac as well as the medial otic epithelium between stages 15 and 23. Expressed in the otic vesicle, somitic mesoderm and notochord at stage 13. Through the cranial region, expressed at the surface ectoderm, head mesenchyme, optic cups, roof plate of the forebrain and notochord at stage 13. In the paraxial mesoderm, expressed in the cranial region of the presomitic mesoderm at stage 13. In the somitic mesoderm, expressed in the somite before de-epithelialization and subsequently in the dermomyotome at stage 13. In the caudal region, expressed in the notochord, paraxial mesoderm and endoderm. Expressed in the optic cup, otic vesicle and somitic mesoderm stage 19. Expressed in the mesenchymal cells surrounding the optic cup and the surface ectoderm overlying the lens vesicle at stage 19. Expressed in the mesonephric ducts and tubules at stage 19. In the somatopleure and limb buds, expressed in the surface ectoderm and mesenchymal cells immediately beneath the surface ectoderm at stage 19. In the somitic mesoderm, expressed in the dermomyotome and lateral sclerotome at stage 19. Expressed in the branchial arches and maxillary process at stages 22 and 23. In the somitic mesoderm, expressed in the myotome at stage 24. In the limb buds, expressed in the anterior region of the fore- and hindlimb buds at stage 24. In the developing inner ear, expressed in the medial side of the utricle, the saccule, and the emerging cochlea at stage 27
+Probably maternally supplied, the zygotic expression becomes significative at the 512-cell stage and increases until 10 hpf and then decreases but is still detected at 24 hpf
+Specifically expressed during male meiotic germ cell development. First detected in early pachytene spermatocytes. Expression is highest in elongating and round spermatids and decreases thereafter. Not detectable in mature spermatids
+High levels in developing brain and spinal chord, sensory neurons of dorsal root and trigeminal ganglia, myenteric neurons of the intestine as well as in non-neuronal cells of adrenal, thymus and submandibular glands of 15 dpc embryos
+Expression is highly restricted to the phase of neurogenesis with high levels in all cells in the ventricular zone (VZ) at 10 dpc. Expression disappears at the end of neurogenesis (18 dpc). However, it remains present in a specific adult neurogenic region with the highest amplification and neuronal output, the subependymal zone of the lateral ventricle from where newborn neurons migrate to the olfactory bulb (at protein level)
+Constant expression throughout development (PubMed:15691769, PubMed:29880558). However, expression decreases prior to the L2 larval stage, increases at the beginning of the L3 larval stage, and then decreases and plateaus from the mid L3 larval stage onwards (PubMed:31910362, PubMed:29880558). In the nervous system, expressed as dim speckles in developing DD motor neurons from the 3-fold stage of embryogenesis, then expression is dim in neurons of L1 stage larvae (PubMed:31910362). At the L2 larval stage, it is highly expressed in epidermal cells and motor neurons (PubMed:31910362). At the L4 laravl stage, it is expressed in all cell types and in the spermatheca (PubMed:31910362)
+Highly expressed throughout development
+Weakly expressed throughout development
+Expressed in fetal neocortex, with highest expression in the developing frontal lobe. Expression increases with development from 9 to at least 17 postconception weeks (PCW). At 11 PCW, expression in frontal lobe is detectable in the ventricular zone and subventricular zone. At PCW 17, highly expressed in the frontal lobe of fetal neocortex, but not in the occipital lobe
+First observed in seeds at early stages of development, mostly in embryo and, at lower extent, in the endosperm. Accumulates and peaks at maturation. Fade out during late seed development steps, restricted to the inner layer of the seed coat, and, at very low levels, in the mature embryo and the remaining endosperm. Also present in the lignified inner subepidermal layer of the valves
+Transcribed during the stage II, but not required until stage IV of sporulation
+Expression is first detected in the male gonad at 11.5 dpc, peaks at 14.5 dpc, declines slightly by 15.5 dpc, and continues to at least 17.5 dpc
+Miracidia
+Expressed during fruit ripening (PubMed:23265513, PubMed:25849978, PubMed:28155115). During storage, highest expression is on day 3, decreasing until day 12 where expression increases again, but after which it decreases sharply until end of storage (day 18) (PubMed:23265513). Expression is very high in immature growing fruits, with the highest expression 100 days after full bloom, after which expressed at low levels during the mature stage (PubMed:25849978, PubMed:28155115). Expression in fruits during storage at 25 degrees Celsius is lower than the expression at the time of harvest (PubMed:25849978). Expression in young leaves is significantly higher than in mature leaves (PubMed:28155115)
+Mostly restricted to cells of the nervous system. Expressed in NGF-dependent neurons of the PNS, but also found in subpopulations of CNS neurons, like spinal cord motoneurons, retinal ganglia cells and EGL cells of the cerebellum
+Expressed in macrophage precursors as they migrate from the midline to the yolksac during somatogenesis. Prior to blood circulation, continues to be expressed in maturing macrophage precursors in the yolksac and in those that have migrated to the mesenchyme of the head. At 28 hours post-fertilization (hpf), also expressed in the caudal part of the axial vein and the surrounding mesenchyme
+During embryogenesis, expressed in several tissues in which cellular differentiation is regulated by the notch signaling pathway. At 10.5 dpc expressed in intersomatic vessels and in vessels of the limb buds with strongest expression at vascular branch points. Cyclic expression between 8.5 dpc and 10.5 dpc somitogenesis is dependent on DLL3
+Expressed both maternally and zygotically. Expressed from mid-gastrula (around stage 10.5) and persists at least through to tadpoles (stage 41)
+Gene expression gradually increases from 36 to 96 hours post-fertilization (hpf). At 12 hpf, expressed broadly, but at 26 hpf, the expression clusters around the otic vesicle, pectoral fin, and midbrain
+Expressed throughout development. Expression rises within 6 hours after the initiation of development and gradually decreases following the mound stage. Expressed in vegetative cells
+Expressed in the neurula and persists during embryogenesis in the brain, cranial nerves and spinal cord
+Detected at 8 dpc in developing organs, including brain, heart, lung and intestines. Expressed at 14 dpc and 16 dpc at the periphery of developing organs such as bones and teeth
+Barely detectable during early stages of active growth and differentiation, exhibits dramatic increase between 30 and 48 hours of development. This late embryonic stage marks a period of continued maturation and moderate growth of most organs, but is also characterized by initiation of cellular growth arrest and terminal differentiation in many cell types
+Expressed during parasite asexual blood stages, specifically at the schizont stage (at protein level)
+At 13.5 dpc, weakly detected in utricle sensory epithelium but not in hair cells. At 16.5 dpc, more prominently detected in crista hair cells. Hair cell expression is sustained in postnatal mice. In cochlea, detected in cochlear hair cells in embryo and in hair cells and the greater epithelial ridge (GER) region in early postnatal age
+Expressed both maternally and zygotically (PubMed:8026338). Localizes to the posterior pole of the oocyte during stage 9 of oogenesis (PubMed:14973490)
+Low expression in cotyledons, increasing with leaves development
+Expressed in source leaves and sink leaves
+At the seedling stage, present in the veins of cotyledons, hypocotyls, roots and germinated seedlings (PubMed:31038749). Later observed in leaves, primary and secondary roots, floral tissues, siliques and guard cells (PubMed:31038749)
+First detectable at the migrating slug stage. Observed throughout slug migration and culmination, and remains present in tip organizer cells
+Reaches a maximum during the meiotic and the postmeiotic stages of germ cell development
+Widely expressed in the developing brain, particularly in the neural progenitor cells of ventricular zone and the intermediate zone of the cerebral cortex. Expression peaks at 11 dpc and declines at 15 dpc and 17 dpc. After completion of neuronal migration expression is reduced in the cortex
+Detected in leaf primordia. In leaves, present in the blade and the petiole, especially at the dispersed meristematic regions and the leaf margin. Accumulates in floral organs
+Detected in the embryo and leaf primordia at earlier developmental stages (PubMed:18305007). In reproductive organs, expressed in the inflorescence meristem, floral primordia and four types of young floral organs (PubMed:18305007)
+Expressed in the early cleavage stages of the embryo. Expression decreases at the gastrula stage and subsequently reappears at the neurula stage, and continues to increase from this point on. In post neurula stages, expressed predominantly in the anterior region of the embryo, including the developing brain and sensory organs
+Not detected until 11 dpc. Restricted to developing central nervous system in 13 days embryos
+Expressed both maternally and zygotically. Shows lower zygotic expression than hes4-B/hairy2b
+The concentration of AAC-rich mRNAs is low in dormant spores and growing cells, but increases during spore-germination and multicellular development
+Highest expression in young root tips
+Thought to be expressed early in embryogenesis
+Increases moderately during pregnancy (2.8-fold increase on day 4) and lactation (1.9-fold increase on day 2)
+Maternally expressed. Present from the one-cell stage to the gastrula stage. Present in all blastomeres until the midblastula stage. The expression is restricted to the epiblast during gastrulation, and to the neural plate after gastrulation. In the adult, expression is limited to the ovary
+Undetectable in embryonic spleens. Weak expression is detected the first week after birth, with further increase to normal levels by 4-6 weeks after birth
+Expressed during synaptogenesis. Found at the cell surface of excitatory synapses
+Expressed throughout all developmental stages. Detected in the M5 pharyngeal neuron only in larvae. Also persistently expressed in the intestine of adults past the molting stage
+Expression increases during vegetative growth and decreases soon after entry into sporulation
+Eggs, larvae and adult
+In embryonic stem cells it is found from day 6 of gestation. It reaches a peak on day 8 and gradually declines during the rest of embryogenesis
+Expressed preferentially during the multicellular stages of development
+Widely expressed throughout embryogenesis, starting at the two-cell stage and probably expressed both maternally and zygotically (at protein level)
+Mainly expressed in fetal heart and muscle
+During seedling development, expression is hardly detected during the first 2 days after imbibition, and then increases to reach a peak after 9 days
+Detected at low levels in fertilized and unfertilized eggs. Levels increased in two-cell embryos, decreased up to morula stage and were highest in blastocysts. Highly expressed in the inner cell mass of 3.5 day old blastocysts. Highly expressed in ectoderm and visceral endoderm at day 5.5. Detected throughout the brain and spinal cord at day 10 to 15. Detected in the basal layer of the epidermis after day 12.5, in particular on snout and distal on fore- and hindlimbs
+Expressed during seed maturation (PubMed:14555856). Expressed in mature raw cashew nut (PubMed:18558706, PubMed:21138244)
+Expressed during all pre-implementation stages in both male and female embryos
+Very low expression in eggs. Expression increases during larval stages, decreases in pupae and increases again in adults
+Specifically expressed at stage 2 during floral development
+Expressed throughout the life cycle, but expression is slightly decreased during encystation
+Expressed at late-developmental stages. Spore cell specific
+Highest expression is found in E1-E3 embryos with a significant decrease after 3.5 dpc
+Expressed during kidney development
+Throughout development, highest in embryos
+Expressed at the time when separation of neural and epidermal precursor cells occurs. Accumulates transiently at the fusion sites of anterior and posterior midgut and very specifically to high levels in the proventriculus of the embryo. Not expressed in the imaginal disks of third instar larvae
+At the mRNA level, expressed at low levels in the developing brain before 16 dpc. Expression markedly increases during early postnatal stages with a peak at P14. At this stage, expressed throughout the brain, with high levels in the cerebral cortex (cortical layers), hippocampus and cerebellum (granule cells and Purkinje cell layers). Progressively declines to relatively low levels in adulthood. At the protein level, first detected at very low levels at 17.5 dpc. Expression increases at early postnatal stages in the cerebral cortex, hippocampus and cerebellum. Expression increases to reach a plateau around P14, a period of intense synapse formation and rearrangement, and starts to slightly decrease around P90 (at protein level) (PubMed:27052163, PubMed:29056747)
+Detected at low levels in the brain at postnatal day 5 (at protein level) (PubMed:17190793). Expression in the brain is increased by postnatal days 9 and 10, and continues to increase at postnatal days 15 and 20 (at protein level) (PubMed:17190793)
+Found to decrease dramatically after birth
+Expression is independent of the cell cycle in lung fibroblasts
+Expressed from embryonic stage 9.5 dpc to 14.5 dpc. Detected in tissues from all three germ layers, with particularly strong expression in mesodermal derivatives. Strongly expressed in somites and also detected in limb bud mesenchyme, apical epidermal ridge (AER), otic vesicle, and nephrogenic mesenchyme. Expression in somites follows an anterior-to-posterior gradient of activation and localizes to somite myotomes. In limbs, first detected at stage 10.5 dpc, probably in a subset of muscle precursor cells. Expression in developing muscles continues during stage 14.5 dpc. Found in a subset of tendon precursors, particularly in the distal region of the limb. Also detected in ectoderm at the digit tips. Other notable sites of expression at stage 11.5 dpc include skin epithelium in the posterior embryo, thyroid rudiment, ventral neural tube, roof plate, floor plate, dorsal aorta, sympathetic chain ganglia, endolymphatic duct, otic vesicle epithelium and vascular wall
+First expressed at embryonic day 3. Maintained at high levels between days 4 and 7 and declines thereafter to stabilize at low levels after day 10
+Maternally expressed in oocytes
+Expressed during the recovery phase of the reproductive cycle. Not expressed in any other phase of the annual cycle (at protein level)
+Expressed early during embryonic development
+Preferentially expressed in developing organs
+Specifically expressed in early male embryos. Zygotic expression first appears in 2- to 3-hour-old embryos (cellularized blastoderm stage). Expression is then maintained throughout male development until adulthood
+Low expression in the various developmental stages, although relatively high levels detected in 8 to 12 h embryos, as well as in pupae and adults, particularly in the head region. Expressed in third-instar eye imaginal disks posterior to the morphogenetic furrow where photoreceptor differentiation occurs. Preferentially detected in wing imaginal disks in two stripes of cells interrupted at the dorsoventral boundary, which correspond to the developing veins L3 and L4. In pupal wings the maximal levels of expression are present in all longitudinal veins, with low levels detected in most intervein cells. Uniformly distributed in the syncytial blastoderm (stage 4). At early stage 5, accumulates at the embryonic poles and is absent from the central region. This pattern evolves very rapidly with the formation of a third central domain of expression from 85% to 40% egg length. In older embryos, the main places where high levels accumulate correspond to the invaginating mesoderm, the tracheal pits at stage 11, the visceral mesoderm at stage 13, the heart, the midline and the apodema. Expression in tracheal branches at later stages
+During flower development, expressed in the tapetal layer surrounding the male microsporocytes, and in the endothelium layer surrounding the embryo sac within the ovule. During embryogenesis, expressed in all cells of the embryo and in developing endosperm surrounding the embryo, at the time of free nuclei proliferation
+Expressed in the retina from postnatal stages to adulthood. Highest levels are observed at postnatal stage P1 and P4 and expression decreases afterward. Steady levels are observed from P12 to adulthood. Expression increases in the outer segments from P12 to P19 paralleling the differentiation of outer segments
+Expressed both maternally and zygotically. Expressed throughout all developmental stages but is most abundant at precellular blastoderm stages; expression declines after gastrulation. Expressed at higher level in adult females. Following germ-band retraction it is enriched in the developing central nervous system. In third-instar larvae, low levels are detected in the brain hemispheres and imaginal disks
+Expressed at a low level throughout all developmental stages. Expression levels significantly increase after the mid-tailbud stage and are maintained through the tadpole stage (stage 40)
+Expressed in the skin at birth
+Expressed at 12.5 dpc in almost all tissues tested. Expressed at 14.5 dpc in brain, eye and liver. Weakly expressed in lung, heart and kidney
+Expressed maternally
+Expressed in all developmental stages, increasing gradually from embryo to larval L3 stage, decreasing in L4 and stabilizing in adult stage
+Adult
+Cell-cycle regulated. Increases during G2/M phase and then reduces after exit from M phase
+First detected at embryonic day 7 and became clearly visible at day 11 and increased until day 17
+Expressed in the hypodermis of embryos prior to hatching and expression is enhanced in the hypodermis before each molt. Expressed during larval development in the excretory duct at the L1 stage, and during morphogenesis of the somatic gonad and vulva during the L3 and L4 stages with prominent expression in the uterine seam cell and toroidal vulE and vulD cells
+First detected in testis in two week old mice; expression continuously increases in testis from 2 to 8 weeks after birth and remains at a constant level in 6-month-old testis
+Expressed mainly in pachytene and secondary spermatocytes and round spermatids and predominates in stage VI-VII tubules
+Expressed at 15 dpc in the interscapular region of the embryo, that could correspond to the developing brown adipose tissue. Expression continues in the interscapular region at 18 dpc and postnatally. In mammary glands, begins to be highly expressed at day 14.5 of pregnancy. Expression is maintained at high levels throughout lactation and declines during post-lactational involution
+Expressed in atrial and ventricular chambers of the primitive heart at 9 dpc. Expressed in somites at 11 dpc. Expressed in atrial and ventricular chambers and interventricular and interatrial septum at 13 dpc. Expressed in myotubes between 13 and 15 dpc. Expressed in skeletal muscles at 18 dpc
+Expressed in the germ cells following microspore division, increases during development and persists into mature pollen
+Liver from adult female rats contains about 2-fold greater levels of YC1 than is found in liver from adult male rats
+Induced during puberty
+Restricted to differentiating vessel elements of protoxylem and metaxylem
+Strongly expressed during embryogenesis
+At 14 dpc, highly expressed in brain and the highest level is detected at 16 dpc and 18 dpc. Following birth, levels are barely detectable and stabilize at low levels starting at 20 pnd through adulthood
+Elevated levels during postnatal muscle growth
+At postnatal day 3 (P3), detected in heart and plasma, expression decreases with lower levels at P7 to, at least, P13
+Expressed in the embryonic ectoderm before gastrulation, and gradually restricted to the anterior part from the mid to late streak stage. Becomes restricted to the dorsal side of the neural tube at 8 dpc. After neural tube closure, is expressed in the dorsal midline of the entire neural tube and in the roof plate. Also expressed in the developing limb buds
+Expressed during floral development
+Expressed on days 0-7 after adult emergence at roughly constant level (at protein level)
+In the root endodermis, expressed at a late developmental stage, coinciding with the appearance of metaxylem vessels. In 10-day-old roots, reduced levels in proximity to the hypocotyl and in endodermal cells overlaying lateral root primordia
+The level of expression in seedlings and in juvenile plants is higher than the level of expression in adult plants
+Expression reaches a peak in the G1/S phases and then decreases in the G2/M phases
+Highly expressed in embryonic kidney and brain
+Expression reaches a maximum at postnatal day 7 before to significantly decrease
+Embryonic development
+Constitutively expressed over circadian time (at protein level). Not autoregulated
+Expressed throughout development with the highest expression in embryos from 4 to 12 h. Expressed in the salivary glands from stage 11, when the placodes are being specified
+Sea urchin larval development
+Expressed in fetal kidney and fetal liver
+Fetal skeletal muscle, esophagus, kidney, and lung
+Expression increases in the spinal cord from 4 dpc to 16 dpc, with the highest level detected between 12 dpc and 16 dpc. Expression rapidly decreases after hatching
+Expression begins at the gastrulation stage (PubMed:23457234). Expressed broadly at L1 larval stage except in the intestine (PubMed:23457234). Expression decreases in the subsequent larval stages and is absent in adults (PubMed:23457234)
+Very low expression levels in testis before postnatal day 25 (P25). Levels strongly increase between P25 and P30, and then remain high from P30 through P150
+First detected at stage 17 as two symmetric patches in the region of the presumptive olfactory placode. Expressed in the pineal at stage 23, and in the eye starting from stage 24. By stage 27, strongly expressed in retina, olfactory placodes and pineal. At stage 32, expression strongly decreases in olfactory placodes and pineal but is maintained in the neuroretina. At stage 41, expression is restricted to the ciliary marginal zone of the retina
+Present throughout the mitotic and meiotic cell cycle
+Expressed in embryo at 17 dpc
+Expressed throughout pituitary development (PubMed:7811383, PubMed:7708713). Detected at 11 dpc in the primordium of the hypophysis (PubMed:7811383). Following a maximum between 12 dpc and 14 dpc, lower levels persisted into adulthood (PubMed:7811383, PubMed:7708713). Expressed at 11.5 dpc and 12.5 dpc in developing spinal cord, especially in motor neurons (at protein level) (PubMed:18539116)
+In spermatocytes, first detected at the transition from leptonema to zygonema, localizing specifically to initial sites of homolog synapsis. The number of synaptonemal complex-associated Rnf212 increases as synapsis proceeds. Excluded from unsynapsed homolog. In early pachynema, as cells complete synapsis, detected as a punctate pattern of irregular foci along the synaptonemal complexes. Also localizes to the synapsed pseudoautosomal regions of the X-Y chromosomes. After early pachynema, protein levels strongly drop. By midpachynema, Rnf212 foci only remain at sites where crossovers form. Remaining foci disappear in late pachynema before the disassembly of synaptonemal complexes at diplonema and are not detected in early diplotene-stage cells in which homologs begin to desynapse. Pattern in fetal oocytes is very similar, except that the late-stage Rnf212 foci are still detected in nuclei in both the late-pachytene and early diplotene stages (at protein level)
+Expressed during seed maturation. Expressed in maturing seeds about 2 and half weeks after flowering. Expression continues steadily thereafter until it decreases in the seed-drying stage, reaching undetectable levels in mature seeds
+Expressed during ovule development (PubMed:25378179)
+Isoform 1 expression is high during embryogenesis, modest during larval and pupal stages and abundant in adult. Isoform 2 is expressed at low levels in 0-4h embryos and at very low levels during the rest of developmental stages and in adult
+Probably maternally supplied, the zygotic expression becomes significative at 4.0 hpf and remains constant until 24 hpf
+During arbuscular mycorrhizal (AM) symbiosis, accumulates in root cortical cells, root tips and lateral root primordia, restricted to colonized root segments
+Expressed in the wing disks and wing veins, possibly on the surface of hemocytes (at protein level) (PubMed:35609633). Expressed during third-instar larval stage in wing disks in a stripe of cells at the anterior-posterior (A/P) compartment boundary, in the epithelial folds located in the central part of the wing pouch but with diminished expression along the dorsoventral (D/V) boundary (at protein level) (PubMed:35609633, PubMed:35037619). In pupal wings at 24 hrs, after puparium formation (APF), detected in a row of distal anterior cells (at protein level) (PubMed:35609633, PubMed:35037619)
+Expressed in the otic placode beginning at stage 10 and exhibits a dynamic expression pattern during formation and further differentiation of the otic vesicle
+Expressed from larval stage L1 to adulthood
+Expressed at higher levels in the cerebral cortex of juveniles than adults (at protein level)
+Expressed in the later, cell expansion, stages of seed development
+Very high expression in immature colored petals, then decreases in mature colored petals
+First detected at 14 dpc, expression increases until at least 7 weeks after birth
+Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines
+Observed restrictively in brain throughout embryonic and postnatal stages. Expression pattern in brain slightly changes from 13 dpc to postnatal day 21 (P21). Expressed in both cerebrum and cerebellum throughout P0 to P35. In the cerebrum expression reached a plateau at P14 while expression in the cerebellum remains constant throughout all postnatal stages
+Low level expression seen in the heart between 8.5 dpc and 15.5 dpc. Expression levels increase progressively after birth, with the highest levels seen in adults
+Expressed during male meiosis specifically in male meiotic cells (male meiocytes within anther locules). Expressed during female meiosis specifically in the female meiocytes within the ovule
+First expressed at day 9.75 of embryogenesis in the apical ectodermal ridge (AER) of the developing limb buds and at the edges of branchial arches 1 and 2. Also expressed in the ventral neural tube, notochord and sympathetic ganglia and the mesonephric tubules of the developing kidneys. In the heart, it is expressed in the myocardium of the atrium and in the endocardial cushions of both the developing inflow tract and the atrioventricular valves. At day 15, it is expressed in the cartilage of developing bones, in vertebrae and cartilage of the trachea as well as in the thymus. In the forelimb, it is expressed in all developing bones, but absent from developing joint regions and was down-regulated in chondrocytes beginning to undergo mineralization, such as in the center of the ulna. At day 15, no expression in the neural tube is observed. In the heart at day 15, it is still expressed in the atrial valve, the atrioventricular valves and in the myocardium of the atrium, while in the kidney, it is expressed in the collecting tubules as well as in Bowman capsule. Interestingly, the liver displays a punctate expression at day 15. Also expressed in tooth primordia, hair follicles and mammary glands
+Highly expressed during the stationary phase and high levels remain in the autolytic stage
+Detected from postnatal day 35 onward
+Expressed embryos at day 11.5. Also expressed in fetal livers with expression increasing dramatically after birth. Expression decreases only slightly after postnatal day 3 and remains abundant thereafter
+Expressed at early stage of flower development in floral meristem, and at later stage in lemma, palea and carpel primordia
+Developmentally regulated with highest expression found in developing areas or in areas capable of developmental plasticity
+Expressed maternally and zygotically through to adult (male and female)
+Expression is already noted at day 9.5 in the limb buds and pharyngeal arches and at day 10.5 in sclerotomes, at various elements of the branchial apparatus (mandible and hyoid), and in the occipital region. At day 15.5 expression peaks in cartilage, preceding hypertrophy and ossification, and at day 17.5 there is no expression in the bones
+Specifically expressed in endosperm of developing seeds
+After the establishment of chromosomal sex at fertilization
+Found in hyphal but not yeast forms
+Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2
+Expression is low in meronts, but becomes induced when meronts start to differentiate into sporonts
+Expressed during larval development and strongly down-regulated in adults
+Localized in trichome developing region of leaves, prior to trichome initiation. Levels increase in initiating and young trichome cells, but dropped in the pavement cells between trichomes. Disappears in mature trichomes
+In roots, restricted to the root apical meristem (RAM) in a pattern positioned just above the quiescent center (QC); strongest levels are observed in the meristematic cortical cells, but also detected in the epidermis and within the vasculature (PubMed:23370719). Induced during lateral root formation after the emergence of the primordium (PubMed:23370719)
+Detected from postnatal day 14 onwards. Maintained at high levels through to adulthood
+Detected during flower and leaf development. Expression in the flower meristem in the early stage of flower development. When carpel primordia begin to form, specific and uniform expression in carpel primordia. Expression in the central region of the leaf plastochron 1 (P1) primordia. Detected up to P4 stage, hardly detected in the P5 leaves
+First detected in the early streak embryo, specifically in the epiblast layer. At the late streak stage, expression is condensed in the rostral half of the primitive streak. At HH stage 4 expression appeared for the first time in the mesendodermal layer of the presumptive prechordal plate rostrally and in the expanding mesoderm laterally. At HH stage 6, labeling in mesendodermal progenitors underlying the future forebrain level of the neuraxis reached its maximum, whereas mesoderm expression, which was restricted to the lateral plate, was accompanied by an underlying endodermal expression at the level of the heart-forming regions. Later gastrulation (HH stage 5-7) was marked by strong expression in the notochord, beneath the future floor plate of the neural tube. Expressed in Hensen node, within its mesenchymal core beneath the epiblast, and at a time when it is morphologically asymmetric
+Expressed in 200-cell stage embryo (PubMed:10476968). Expressed predominantly in QR neuroblast descendants and to a lesser extent in QL neuroblast descendants during larval stage (PubMed:25373777)
+Its expression is associated with the early G1 phase of the cell cycle
+Detected in embryo. Expression is very low in larvae, pupae or adults
+First expressed during late neurula stage (stage 18). Levels increase slowly up to the tailbud stage (stage 28), then increase sharply before remaining approximately constant through the remaining tailbud and tadpole stages (stages 30-44)
+Expressed at the outer limiting membrane of the retina at 3 months of age
+Expressed at all stage of development with an increase from 8 hours after starvation
+Expressed in developing caryopsis from 5 to 15 days after flowering
+Expressed in early G1, during G0-G1 transition as well as in cycling cells
+Expressed in placenta at 14.5 dpc. Expressed in the single layer of endodermal epithelial cells of the visceral yolk sac at 15.5 dpc (PubMed:26952984). Expressed in syncytiotrophoblast and trophoblast giant cells of the labyrinth region of the placenta at 17.5 dpc (PubMed:15814898, PubMed:26952984) (at protein level). Expressed specifically in extraembryonic structures, in placenta from 9.5 to 18.5 and yolk sac/amnion from 12.5 to 18.5 (PubMed:15814898, PubMed:26952984). Expressed in the labyrinthine layer of the trophoblastic placenta at 10.5, 12.5 and 14.5 dpc (PubMed:15814898). Expressed in syncytiotrophoblast and trophoblast giant cells, less in spongiotrophoblast cells, and not detected in maternal decidua or in allantois at 17.5 dpc (PubMed:26952984)
+Low expression is detected in preadipocytes, mainly localized in primary cilium
+Expressed in fetal liver
+Specifically expressed in the developing cardiovascular system with higher expression in veins. First detected in the developing anterior cardinal vein at 8.75 dpc. Abundant expression at 16.5 dpc in various organ systems, including thymus, heart, lung and kidney, where it is associated with cells of endothelial origin. In myogenic progenitor cells, highly expressed during early development (11.5 dpc) and progressively repressed as developments proceeds (PubMed:27446912)
+Present in all stages of development
+Detected in the testis after postnatal day 28
+Expressed in embryo and adult. Embryonic expression is detected from 12 dpc
+Transcripts are weakly expressed in gastrulae, early and late planulae, metamorphosing planulae, and primary polyps
+Expression increases during adipogenesis
+At stages 3-9, expressed in the neural plate/tube. Seen at stages 10-15 in the somites. At stages 15-19, expressed in the dorsal trunk ectoderm and myotome
+Expressed at promastigote stage but not in lesion-derived amastigotes (at protein level). Expressed during the differentiation of promastigotes to amastigotes in vitro
+Expressed in the developing oropharynx and nasopharynx at 13.5 dpc, in the mandible at 14.5 dpc and in the cartilage primordia of the nasal bones, palate and tooth germs at 17.5 dpc. Detected in the embryonic liver at 13.5, 14.5 and 17.5 dpc
+Expressed in lateral root primordia during auxin-induced lateral root development
+Detected at 6-7 hours post-fertilization (hpf). Levels increase after 10 hpf and highest expression is seen at 24 hpf
+During the cell cycle, expression is increased during S phase and G2/M phase
+Expression low before and high after pollen mitosis
+Detected already at 4.5 dpc, expression peaks at 11.5-12.5 dpc and gradually declines to its adult levels by 18.5 dpc
+Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in any part of the hindbrain. At day 8-8.5 post-coitum found in the embryonic mesoderm, anterior to the first somite, up to the cephalic region at the level of the foregut and developing heart. At day 9 post-coitum found in an anterior part of the developing foregut and is restricted to an epithelial cell type. Expression in the gut is found at the level of the second to third branchial bars
+Highly expressed in late-maturing seeds and in geminating seeds (at the protein level)
+During female gametogenesis, expressed in the female gametophyte at stage FG4 (four-nucleate stage) in all four nuclei. Expressed in the central cell in unfused polar nuclei at stage FG5 and secondary nucleus at stage FG6. Not expressed in mature female gametophytes (stage FG7)
+Up-regulated in aspidocytes, a resistant cell type induced by a range of toxins including heavy metals and antibiotics
+During embryogenesis, present in the embryo at the globular and heart stages. Detected in the central vasculature of the siliques. During germination, only observed in stipules at the shoot apex and restricted to trichomes of the primary leaves
+60S ribosomal protein L40 and Ubiquitin: Expressed at high levels in fully sporulated oocysts and merozoites. Low levels found in unsporulated oocysts. Absent in partially sporulated oocysts
+In flowers, accumulates in the female gametophytes at different stages, as well as in early embryos and endosperms
+Present in vegetative and developing cells
+During male gametophyte development, expressed at the early microspore stage just after tetrad separation, polarized microspore stage, bicellular stage, mature pollen stage, anthesis stage and open flower stage. Expressed in germinating pollen grains and elongating pollen tubes
+Expressed exclusively within heterocysts
+Ubiquitously detected in embryonic tissues, and down-regulated in certain adult tissues (at protein level). Isoform 3 is widely expressed in embryonic tissues (at protein level). In adults is detected in spleen and gut, and is almost undetectable in heart, skeletal muscle, liver, and kidney (at protein level). Isoform 4 is widely expressed in neonatal tissues (brain, heart, lung, stomach, intestine, kidney, bone and skin) (at protein level). Late in development expression is restricted to cardiac muscle and to organs rich in smooth muscle (at protein level). Isoform 1 is detected in neonatal striated muscle and bone, and remains highly expressed in adult skeletal and cardiac muscle (at protein level). Adult brain express an isoform of 80-85 kDa. At 8.5 dpc is mainly expressed the rostral and caudal part of neural plate. No expression is detected in somite. At 9.5 dpc and 10.5 dpc is ubiquitously detected
+During osteoclast development, expression increases as the cells differentiate with high expression levels in mature osteoclasts (at protein level)
+Expressed during the asexual blood stage; expression begins in late rings, increases in trophozoites and continues in schizonts (at protein level)
+Expressed during seed development at the mucilage production stages
+Expressed from 1 day post-fertilization
+Expression starts in the embryonic ectoderm in the uterus on 6.5 dpc. Then it is strongly expressed in the neuroepithelium of the neural tube, the developing brain and the spinal cord from 8.5 dpc to postnatal day 7 (P7), in the cranial motor nerves from 9.5 dpc to 11.5 dpc, and in the optic nerve from 13.5 dpc to P7. Expression increases until perinatal period and decreases postnatally. Expressed in the immature neuroepithelium including progenitor cells it still occurs in a few proliferating cells of the hippocampal dentate gyrus, the subventricular zone of the lateral ventricles, and the rostral migratory stream over P21. Also expressed in heart, kidney and liver of newborn mice
+Expressed in developing embryos up to the heart stage
+Expressed in early tail-bud embryos at stage 20 in the brain region of the neural tube and at lower levels throughout the remaining length of the neural tube. Present at stage 32 in the forebrain, midbrain, the ventral half of the hindbrain and the spinal cord
+Expressed in early embryogenesis. Found in the peripheral and central nervous systems
+Expressed in pstAB cells in slug stage, spreading to all prestalk cells in culmination
+Expressed at low levels at earlier developmental stages and induced at high levels during culmination dependent on transcription factor srfA
+Not detected in any embryonic stages tested. Weakly expressed in adult testis
+Expressed in flower buds at stage 6 of development in tapetal cells and at stage 10 in the epidermal cells of growing petals and ovaries. In young siliques, expressed transiently in the inner integument of the ovules just prior to testal deposition. Expressed in the developing embryo with a maximal level at the heart and torpedo stages. The expression then disappears in the mature embryo. During seed germination, expressed in the vascular bundles, apical meristem, epidermis of the seedling cotyledon, stem, and root. Highly expressed in the root tip of seedlings 4 days after imbibition
+Expressed from 11 hours post-fertilization (hpf). Expression in the midbrain and optic primordia begins at the onset of segmentation and increases to 14 hpf, remaining strong during lateral migration of the optic primordia. Expressed in the neural tube and the oblongated retinal epithelium from 18 hpf. Expression within the differentiating eyes subsequently decreases from 22 hpf to 35 hpf, with only weak expression at the edge of the lens observed from 35 hpf to 48 hpf. Expressed in the branchial pouches from 22 hpf, and in the pharyngeal arches, ganglia and hindbrain and spinal cord neurons from 24 hpf. Expressed in the lens perimeter and the differentiated amacrine and ganglion cell layers at 72 hpf
+In flowers, present in petals, stamen, and pistils styles and stigma
+Only present in A-cells and in a/A diploid cells
+Expressed throughout the forebrain and midbrain during development, and in addition is also seen in discrete spatial and temporal domains in the developing cerebral cortex and cerebellum. Confined to a subpopulation of neurons in layers 5 and 6 within the adult cerebral cortex and during development expression is high in the progenitors of these deep-layer cells. Expressed in the developing cerebellum in spatially restricted regions of the external granular layer
+Highly expressed in root pericycle and cell suspension culture during cell cycle arrest. Expressed early in the G1 phase and then disappears. More abundant in endoreduplicating than in mitotically dividing tissues (at protein level)
+Highly expressed in the male and female gametophytes and in seedlings
+Expressed during stationary-phase and exponential-phase of growth
+First detected at 3 weeks of age. Expression increases through to 6 weeks of age and remains high thereafter
+Mainly expressed in heart and developing limbs
+Expressed in the fetal brain, liver and kidney
+Expressed in both stages of the parasite life cycle
+Not present in the oocyte or early embryo. Expressed in a number of embryonic tissues at later stages. First detected at stage 9 of embryogenesis, in the epithelium of the stomodeum, which develops into the foregut and in the epithelium of the proctodeal opening. Segmentally repeated expression was observed in the mesodermal layer in stage 11. At stage 13, segmentally repeated ectodermal expression is observed. Also expressed in the epithelium of the foregut and posterior spiracles and the fat body. Detected in both nurse cells and follicle cells during oogenesis. Enriched in follicle cells adjacent to the anterior end of the oocyte
+Maternal gene products found in the early embryo prior to zygotic transcription
+Detected in the mantle layer of the neural tube and in the dorsal root ganglia at 14.5 dpc. In developing skin, expression is restricted to basal layers of the epidermis at 16.5 dpc
+During the mosquito stage, specifically expressed at day 4 post-infection (PubMed:24893340). Not expressed in sporozoites in the mosquito salivary glands and during the liver stage in the mouse host (PubMed:24893340)
+Detected in embryos from 7 dpc to 17 dpc
+Transiently expressed during the early microspore stage
+Expression begins during late gastrulation in seam cells and in few head neurons
+Expressed from gastrulation onwards with predominant expression in the neuroepithelium during neurulation. Expressed in regions of the embryo containing migrating neural crest cells, particularly those emanating from rhombomeres 4 and 6. Expressed throughout the rostral mesenchyme with higher levels of expression in regions containing neural crest cells. At later stages strong expression is seen in the neural crest derived regions of the head, the branchial arches and the pharyngeal pouches. Expression at the rhombomere boundaries increases around stage 16
+The transcript begins to emerged in seeds as early as the second day after imbibition and increased after radicle emergence on the third day. Strongly expressed in the leaves, roots and residual grain of seedling eight days after imbibition. Undetectable in mature dry seeds
+Isoform SERCA1A and isoform SERCA1B are predominantly found in adult and neonatal skeletal muscle respectively
+Present in unfertilized eggs and at the zygote and cleavage stages. Levels increase at the blastocyst stage and with endoderm differentiation
+Expressed in all larval and adult stages but not in pre-hatching embryos (at protein level)
+At a late stage of fiber differentiation
+Not detected before 11.5 dpc and expression levels vary between 11.5 dpc and 15.5 dpc
+Present in the developing vascular bundle systems (PubMed:20151298). In the vegetative phase, expressed in shoot apical meristems (SAM) and leaf primordia (P1-P4 stage) (PubMed:17666027). In the reproductive phase, first observed in the outer several cell layers of the rachis meristem and primary branch meristems (PubMed:17666027, PubMed:20151298). Confined to panicles primodia and young panicles, particularly in the developing rachis branches (PubMed:20151298). Accumulates later in the primary and secondary branch meristems, and in the spikelet and floral meristems (PubMed:17666027). Also expressed in lateral organs of spikelet and floral meristems, such as glumes, lodicules, stamens and carpel, and in the ovule primordium (PubMed:17666027)
+Highly expressed in the initial stages of development (4-cell up to 1k-2k cell stages). Expression slightly increases again between 24 hours and 5 dpf and after 20 dpf. Up-regulated during regeneration of the caudal fin after amputation
+After one day of germination, mainly found in the scutellum of the developing grain; barely detectable after four days, and absent from the mature grain. A lower level of expression is seen in the aleurone both during development and germination
+Detected from the 20 cell embryo stage and continues through to adult, although in a restricted manner
+High levels during embryogenesis, moderate levels during L1 and adult stages and very low levels during L2-L4 stages
+Induced during senescence
+Increased in an age-dependent manner from postnatal 3 to 8 weeks
+Expressed in the myotome part of the mature somites in embryos from embryonic day 9.5 onwards. It is not expressed in the developing heart at these embryonic stages
+Specifically secreted during the embryonic period in the chicken proventriculus (glandular stomach)
+During embryogenesis, expressed in the chalazal endosperm
+Expression levels gradually decrease with aging in both the shoot and root vasculature
+In flowers, localized to vasculature of the stamen filament, in anthers and papillar cells of the stigma. In siliques, mostly expressed in the abscission zone
+Specifically expressed in heart during its development by mesenchymal cells of the endocardial cushions. Expressed in motor neurons at 11.5 dpc. In myogenic progenitor cells, highly expressed, at least as early as 11.5 dpc, expression decreases until 4 weeks after birth (PubMed:27446912)
+Expressed in L2 larvae (at protein level) (PubMed:7822332, PubMed:10743611, PubMed:12742584, PubMed:17933581). Expressed at low level in lung host L3 larvae (at protein level) (PubMed:17933581)
+First detected in 64-cell embryos. Reaches maximal levels at the gastrula stage, decreases in neurula stage and barely detectable in larvae
+Expressed at all stages but more highly during embryogenesis, with expression beginning at the 2E cell stage (endodermal stage). Expression continues to adulthood
+Highest at 12 dpc, where it is expressed primarily in the central nervous system. Highly induced during primary fetal liver erythropoiesis. Expressed in the inner retina during late embryogenesis, predominantly in cytoplasm
+Detected in the brain at 18 days post coitum (dpc) (at protein level). Expression increases after birth, with expression increasing till adulthood
+Expressed primarily in pollen
+In 3T3-L1 cells, expression is transiently induced during early adipocyte differentiation (PubMed:20194620)
+Expressed in the embryo
+Limited to the central nervous system (CNS) at all developmental stages. Peaks 1 day after birth
+Detected in 8.5 to 17.5 dpc embryos
+Expressed during seed maturation
+Expressed only in meiosis
+In developing seeds, accumulates specifically at different stages. First observed at the linear mature cotyledon stage until mature seed, mostly in micropylar endosperm and the seed coat
+Up-regulated during the ripening process of fruits
+First detected at birth, after which expression level is steadily increasing until it reaches a plateau at P15
+Is first expressed in the Koller's sickle (a crescent shaped thickening located at the edge of the posterior marginal zone), and then it is detected in Hensen node which is considered as the chick organizer. Later expression is seen in the anterior most region of the head process (cells that contribute to the prechordal plate at the midline of the pharyngeal mesendoderm)
+Expressed in the anterior to posterior extent of the neural tube including strong expression in the forebrain in the embryo
+Expressed in tapetal layer of developing anthers and then expression gradually increases in developing microspores and in mature pollen
+Detected throughout development (PubMed:18632251, PubMed:20466645). Highest expression levels are found at 0 hours post-fertilization (hpf), probably due to perdurance of maternal transcripts (PubMed:20466645). Ubiquitously expressed during early stages of development (PubMed:18632251, PubMed:20466645). At 16-24 hpf, mainly found in eye, brain and somites (PubMed:18632251, PubMed:20466645). At 30 hpf, has strongest expression in forebrain, cerebellum and hindbrain (PubMed:18632251)
+Expressed in oligodendrocytes of the postnatal optical nerve up to day 30, then the number of expressing cells decreases
+Significantly expressed during endosperm, ovule and embryo development
+In developing flowers, fades out gradually in pollen grains, but accumulates progressively in ovules
+Expression reaches a peak at 48 hours post-fertilization (hpf) and then decreases at 72, 96 and 120 hpf (PubMed:26542022). In embryonic hearts, expression slightly increases between 48 and 96 hpf, and then decreases at 120 hpf (PubMed:26542022). Expressed in the adult heart (PubMed:26542022)
+Expression levels were high during embryonic and neonatal periods (14 dpc to P7) and decreased thereafter
+Expressed in fetal brain. Up-regulated during oligodendroglial differentiation. Expressed in the developing intestine, esophagus, liver, kidney and lung (at protein level)
+Expressed in embryos and newly hatched L1 larvae (PubMed:9875852). In older larvae and adults expressed in P(3-8).p vulval precursor cells and its descendents (PubMed:9875852). Expressed in the major hypodermal syncytium hyp7 during the L3 stage of larval development (PubMed:15621535)
+Expressed in the future mesendoderm during early gastrulation. Expressed in the prechordal plate axial mesoderm and the posterior neural plate in mid-gastrula, and in the anterior neural plate at the end of gastrulation and during somitogenesis. Strongly expressed in and the tail bud and several areas of the brain at the end of somitogenesis
+Isoform 2 is expressed in embryonic brain
+At 12.5 dpc, predominantly expressed in the developing diencephalon. At 16.5 dpc and 18.5 dpc, expressed in the brain, spinal cord, developing neural tubes and tongue but not in the cerebral cortex. At 16.5 dpc, present in developing oral and tooth germ epithelia (at protein level)
+Present in serum and placenta during pregnancy; levels increase throughout pregnancy
+Expressed both maternally and zygotically. Relatively high levels of expression in early embryos, weakly detectable in subsequent developmental stages and enriched in adults (at protein level) (PubMed:31147388). During early embryogenesis, expressed during prophase and interphase in 2- and 4-cell embryos (PubMed:31216475)
+Highly expressed during mid to late S-phase
+During floral development, expressed constitutively
+Expressed predominantly during the early stages of plant growth, peaking at three weeks after germination (at protein level)
+First found between 4-6 days after anthesis (daa). Peaks at 8 daa when the seeds are in the milky endosperm stages
+Expressed in muscle and fat body with levels increasing in the adult stage
+Transcripts are present in granules at the vegetal cortex of oocytes andmove dorsally along with cortical rotation after fertilization
+Not detected at day 7 postpartum (dpp). Levels are low at 12 dpp but increase by 17 dpp. High levels are maintained throughout the remainder of testis development
+Ubiquitously expressed throughout the embryo from fertilization onward. Accumulates at higher levels in the notochord, the ventral floor of the brain as well as dorsal and ventral margins of the myotome
+Preferential expression in young and immature plant tissues. In embryos, expressed from the late globular stage onwards. After germination, detected in leaf founder cells and on flowering, in primordia of all floral organs
+Following spinal cord transection, it is strongly down-regulated at two weeks, during the period of axon dieback. Up-regulated at three weeks, when many axons are beginning to regenerate
+Present during growth and development
+Constitutively expressed during growth and development; not up-regulated by exposure to cisplatin
+Upon induction in a non-magnetic deletion mutant this protein is first found in the cell inner membrane, then collects into foci along the entire cell length from which magnetosome vesicle formation and subsequent clustering occur (at protein level)
+Widely expressed in brain by postmitotic neurons from early development through early adulthood
+Not detected in reticulate bodies (RB) or in elementary bodies (EB)
+Up-regulated in the third stage larvae following infection of host. Concomitant synthesis occurs at a high level through the adult stage. Not detected in microfilariae
+Expressed in the epidermis, nuclei of dermal fibroblasts, cell periphery of flattened keratinocytes, and dermal and epithelial cells lining the excretory ducts of the sweat glands in neonatal foreskin
+Expressed in males and hermaphrodites throughout development (PubMed:17923701, PubMed:9927456). Expressed in early embryos before morphogenesis (PubMed:17923701). In hermaphrodite embryos, first expressed at the 8-16 cell stage of development with expression peaking by the 100-cell stage (PubMed:9217163). Not expressed at the 550-cell stage of embryogenesis (PubMed:9217163)
+In mid instar larvae salivary glands, low basal levels are observed in puff stage 1. Levels increase in late larvae from puff stages 3-10, then decrease abruptly at stage 11. In prepupae, isoform C is the predominant form during the transition between puff stages 18-19. At puff stage 1, expression is also present in the gut. By stage 3 it is present in the wing disks, Malpighian tubules and the fat body. At stage 11, expression is only present in the gut and wing disks
+After fertilization, expressed at the animal pole in embryo, blastomeres and blastula stage (at protein level)
+Young inflorescences (5 mm in size), and 10 mm buds
+Most abundant during early rapid cleavage, blastulation, and gastrulation. Reduced levels from time of establishment of the body plan (around 12 hours) and thereafter
+Expressed throughout plant development, with a lower expression in young plantes and a maximum during flowering
+Expressed in placenta on days 75 and 90 of gestation
+SM20 is expressed in schistosomula and adult worms, but not in eggs
+First detected during the haploid phase of spermatogenesis when secondary spermatocytes begin to appear at about postnatal day 18 (PubMed:30185526). Expression is maintained in mature sperm (PubMed:30239614)
+In flowers, restricted to stigma and style tissues as well as in petals, primarily in the adaxial and abaxial epidermis (PubMed:17611797). Barely detected in leaves, shoots, roots and sepals (PubMed:17611797)
+Expressed in both bloodstream and procyclic forms
+Expressed in embryo between 10.5 and 13.5 dpc
+In the mammary gland, at the mRNA level, expressed in the inactive and involuting stages, but not in the developing, nor lactating stages. However, at the protein level, detected on epithelial cells in the inactive, developing and involuting stages, but not in the lactating stage, and at all stages on myoepithelial cells, while it is not found on adipocytes and fibroblasts
+In flowers, present in pollen within anthers. High expression in the earliest stage of silique development, with a decrease during the middle stages of silique development and subsequently an increase during the later stages
+Highest expression in pro-B-cells decreases with B-cell differentiation
+Expressed in whole embryos and fetuses at 5-9 weeks from conception
+Expressed in basal layer cells of the stratified squamous epithelia at 15.5 dpc (PubMed:29518391). Expressed in the skin after birth (PubMed:29518391). Expressed in ameloblasts at the cervical and apical mid-regions of mandibular molars at birth, abundance at the apical mid-region significantly increases at P1, and is maintained throughout enamel development until P9 when ameloblasts start losing their integrity (PubMed:12657653). Expressed in ameloblasts at the incisal region of mandibular molars at P3 (PubMed:12657653). Expressed at the Tomes' processes of ameloblasts at the incisal region at P5 (PubMed:12657653). Expression at the incisal region decreased at P7 and P9 (PubMed:12657653). Weakly expressed in the spinous and granular layers of the tongue at P20 (PubMed:32758484)
+Expressed in cells competent for DNA transformation; that is 5-15% of the population (PubMed:11918817, PubMed:16009133, PubMed:17630974)
+Maximally expressed in prespore cells. Detectable expression levels during aggregation stage. Maximum expression at the first-finger/slug stage
+Expressed maternally and zygotically. In cellularizing embryos, maternal expression is ubiquitous. At embryonic stage 11, zygotic expression begins in salivary gland precursor cells. In stage 16 embryos, strong expression in salivary glands and part of the proventriculus is detected
+Up-regulated during anther and flower development and leaf senescence
+Expressed in uterus of pregnant females during decidualization from 6 dpc with highest level around 10 dpc declining throughout the rest of the pregnancy
+In the caryopse, slightly expressed during the middle storage phase and was strongly expressed at the later storage phase
+In testis, it is first observed in leptotene and early pachytene spermatocytes. Present at high level in pachytene spermatocytes at stage IX-X and persists throughout spermiogenesis. At spermiation, most of the protein is associated with the residual bodies, but some protein persists in the queues of mature spermatids
+Abundant in the blastula until gastrulation, barely detectable during gastrulation, and increase again during neurulation. Detected throughout the remaining development and in hatched larvae
+Expressed during hypocotyl elongation in the dark
+Highly expressed in neonate and adult, but only slightly in embryos. In 10.5 dpc embryos, it is weakly expressed in the tail bud and limb buds. Expressed in the same pattern than MIB1 in the skin and intestine at postnatal day 1 (P1) and in the hair follicle in the skin in the adult
+Expressed both maternally and zygotically throughout development
+Expressed at embryonic day 15.5 (dpc) in placenta (at protein level)
+At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 7. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to somite 4
+Expressed throughout fruit development
+Expressed both maternally and zygotically from at least the pre-vitellogenic stage I of oogenesis through to the tadpole stages
+Detected only after the 20th day of postnatal development. Mainly expressed in the round spermatids. Expressed mainly in the early stages of spermiogenesis
+Expressed both maternally and zygotically, expression is at low levels in all stages of development
+Expressed in the intestine of adult but not baby rabbits
+Decreased expression shortly before the onset of abscission
+Expressed in cortical cells containing arbuscules of mycorrhizal roots upon arbuscular mycorrhizal (AM) symbiosis with AM fungi (e.g. Glomus intraradices)
+Expressed during the growth phase and throughout the major developmental stages
+Expressed at 16 hours post fertilization (hpf) in the pineal gland, a light-sensitive endocrine organ. Expression in the retinal pigment epithelium (RPE) is initiated in the ventronasal patch at 40 hpf, preceding photoreceptor differentiation by a few hours. During subsequent development, expression in the RPE becomes stronger and more widespread, covering the entire RPE except for the cilliary margin by 56 hpf
+Expressed throughout embryogenesis
+Predominant from the stage VI oocyte through to the neurula stage (30 hours embryo), with levels decreasing at the onset of zygotic transcription
+Up-regulated during adipogenesis
+No difference between normal colonic mucosa and colon tumor tissue in mRNA expression, whereas the protein is expressed 1.5-fold more in normal colonic mucosa that in colon tumor tissue
+Detected in sepals of very young closed buds. Later, expressed in sepals and petals veins and epidermis, as well as in developing gynoecium but not in stamens. At anthesis, confined to the gynoecium, commenced in the anther, and slightly expressed in the anther filament. When petals and sepals withered, strong expression at the bottom of the silique, in the abscission zone, and in the pedicel region below it. At silique maturity, detected in the same region but only at the nectaries
+Weak expression throughout the embryo at 8.5 dpc. As the cells migrate and differentiate during organogenesis, expressed in the spinal cord, forebrain and branchial arches at 9.5 dpc, and also in limb buds at 10.5 dpc. Peak expression at 11.5 dpc in the frontonasal process including telencephalon, maxillary, mandibular and hyoid arches, upper and lower limb buds and midbrain and rhombomere 1 roof plates. Expression decreases considerably from 11.5 dpc to 12.5 dpc (PubMed:21072209). At 8.5 dpc is highly expressed in the chorion and the ectoplacental cone. At 10.5 dpc is highly expressed in multiple trophoblast lineages (spongiotrophoblasts, giant cell trophoblasts, glycogen cells, and labyrinthine trophoblasts). The highest placental level is at 9.5 dpc and subsequently decreases until parturition (PubMed:18163532)
+Widely expressed during embryonic brain development but becomes restricted to the striatum postnatally (PubMed:28433741). Detected in the subventricular zone of the ganglionic eminences at 12.5 dpc. Higher expression levels appear in the lateral ganglionic eminence than in the medial ganglionic eminence. By 14.5 dpc expression remains enriched in the subventricular zone and marginal zones of the ganglionic eminences and is detected at low levels in the cortical plate, developing amygdala, and thalamus. By 16.5 dpc, expression increases in the cortical plate, developing amygdala, and portions of the thalamus and hypothalamus. In the telencephalon, the postnatal expression become more restricted to the striatum (PubMed:28433741)
+Strongly expressed at 7 dpc and gradually declines with the progression of embryogenesis. Expression detected from 7.5 to 14.5 dpc in ectoplacental cone, trophoblast giant cells, and labyrinthine trophoblasts
+Expressed during neural and epidermal differentiation. Primarily expressed in growth-arrested differentiating cells. In the spinal cord at embryonic day 10.5, a strong expressesion seen in the differentiating cells of the intermediate zone at the ventral part of the neural tube and weakly in the ventricular zone. At 11.5 and 12.5 dpc, highly expressed in the intermediate zone and at reduced levels in the ventricular zone that mostly persists in the dorsal part of the neural tube. At 14.5 dpc, expressed throughout the spinal cord. In the developing epidermis at 14.5 dpc, found in the dorsal lateral epidermis. At 17.5 dpc expressed in the cell cycle arrested, differentiating cells of the suprabasal malphigian layer
+Expressed at the comma stage and throughout larval stages and in adult
+Widely expressed in fetal tissues
+Expressed in the prestalk cells type pstAB, this expression being absent in the dstA null mutant
+Expressed at a relatively uniform, low level at most stages of development. Observed in cotyledons and hypocotyls of young seedling. Expressed in apical meristems. Found in the whole roots. Expressed in middle-aged leaves. In flowers, mostly localized in meristems, but is also present in all organs
+Highest levels found in expanding leaves
+Expressed during late developmental phases of siliques
+Expressed in embryonic stem (ES) cells and throughout early embryo development from zygote, preimplantation embryos, to post-implantation embryos. Predominantly expressed in the inner cell mass (ICM) of 3.5 dpc blastocyst and widely expressed in 9.5 dpc embryos
+Early stages of growth after spore germination
+Present at high level in G2 and M phases but declines rapidly in G2 phase (at protein level)
+Expressed at early embryonic stages
+Does not display circadian or circatidal patterns of expression
+Probably maternally supplied, the zygotic expression becomes significative at 4 hpf
+Widely expressed in the developing nervous system during the period of embryogenesis. In first-larval-stage animals, strong expression is observed in ventral and dorsal nerve cords and in the PVM neurons but not in the AVM neurons
+Crystals accumulates between growth and aggregation stage and disappear only after the spore germination
+Detected at age 28 days and was most abundant at age 63 days. No expression at 21 days, seems therefore to be expressed in spermatids and not in spermatocytes or spermatogonia of the germ cells
+Present in young sporophytic tissues (PubMed:28107777). In mature leaves and sepals, confined to vascular tissues at low levels (PubMed:28107777). In mature flowers, high expressed in the filaments (PubMed:28107777). In ovules, detected in both the nucellus and inside the developing embryo sac (PubMed:28107777). After fertilization, observed in the zygote and in the developing endosperm, but fades out two days post pollination (PubMed:28107777). In pollen grains, present in the polarized microspore and at the early bicellular stage, where it is confined to the periphery of the developing pollen grain; later concentrated towards the center (PubMed:28107777). Also expressed at the pollen tricellular stage and in germinating pollen tube (PubMed:28107777). In roots, accumulates in the elongation and differentiation zones, mainly associated with vascular tissues (PubMed:28107777)
+Expressed both maternally and zygotically. Maternal levels decrease rapidly during the early cleavage stages. Zygotic expression begins at neurulation
+Seedling
+Expressed constitutively at very low levels during vegetative growth and throughout development
+Ubiquitous expression at 24 hours post fertilization (hpf) in addition to a distinct expression in the heart at 48 hpf
+Expressed maternally. Expression levels decline during the cleavage stages with only weak expression by gastrula stages. Levels then increase at neurula stages and are high in tail bud embryos
+First detectable in the facial primordia at stage 18 after neural crest migration. Expressed in regions derived from both mid- and hindbrain neural crest. Also expressed in the developing cartilage elements of the limb, first within a restricted population in the prechondrogenic mesenchyme and later in the rounded chondrocytes at the epiphyses of developing long bones
+Expression is first detected at 17 dpc
+Expressed in the whole embryo from 2 to 4 days after pollination (DAP). At 6 DAP, expressed in the regions where the shoot and radicle are developing, and in the aleurone layers and the outermost cell layers of the endosperm. Later, in the embryo development, expressed in vascular tissue, coleoptile, leaf, shoot meristem, radicle, scutellum and epiblast. In mature embryo (20 DAP), expression levels decrease
+Accumulates during aging
+The amount of protein increases in the late logarithmic phase
+Expression does not increase during promyelocyte differentiation
+Found in fetal heart
+Expressed in brain of 3 months, 5 and 10-year-old individuals
+Detected from day 9.5 in various neural and mesodermal derivatives, mainly along diencephalon. Strongly expressed in limb buds, particularly in the morphogenetically active region such as the apical ectodermal ridge (AER)
+Expressed throughout the cell cycle (at protein level)
+Levels remain relatively constant throughout T-cell ontogeny
+In the developing forebrain, barely detected at postnatal day 1. Expression increases from the first week after birth. High levels are reached during 2 and 3 weeks after birth and slightly decrease at 6 weeks after birth. This expression pattern parallels synaptogenesis
+In young seedlings, only observed in lateral root primordia, first in the core region at stage VI, in which cells of outer layer 2 undergo a periclinal division, creating a new internal layer (PubMed:18315543, PubMed:24179095). Maximum levels are reached at the emergence stage, and steeply decrease after elongation of lateral roots, except for residual expression in the region of vascular connection. In two weeks old seedlings, also present in the shoot apical mersitem (SAM) (PubMed:18315543). Accumulates during flower development and during lateral root development. In flowers, present in the gynoecium (PubMed:24179095). Repressed upon floral induction (PubMed:14573523)
+Released during the final stage of cellular desintegration in the senescing endosperm of germinating bean
+Uniformally expressed in the extraembryonic ectoderm at 5.5 dpc. Restricted to the distal part of the extraembryonic ectoderm at 6.5 dpc-7.5 dpc
+Detected in developing brain with a peak at 18 dpc
+Low expression after germination followed by an abrupt level increase in 10-days old seedlings. Accumulates in senescent leaves
+Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5 dpc-16.5 dpc
+Expressed in the retina 17 weeks post-conception (at protein level) (PubMed:29777959). Expressed in the outer neuroblastic zone and retinal pigment epithelium (at protein level) (PubMed:29777959)
+Expressed in prestalk cells, between 16 and 21 hours. Expression peaks at 18.5 hours
+Expressed at all stages of development with higher expression during embryogenesis
+Expressed in the inner retina at postnatal day 5 (P5), and expressed in retinal ganglion cells at P12
+Expressed in shoot and root apical meristems, and in expanding leaves and sepals
+Is synthesized at high levels at a very early stage of embryonic intrauterine development and becomes a major constituent of the primary egg shell
+The differential expression of the fibulin family contributes to the formation of molecularly distinct extracellular matrices already during early developmental stages of a large number of tissues
+Expressed during cardiogenesis
+Expressed in trophozoites (at protein level)
+Expressed throughout the globular-stage, heart-stage and torpedo-stage embryos
+Present in oocytes. Levels decrease during early embryo development and then increase considerably in neurula and tadpole stages
+Expressed predominantly in 10.5 dpc-11.5 dpc neural cells. In the developing spinal cord (10.5 dpc-16.5 dpc), is specifically expressed in proliferating neural progenitors of the ventricular zone. In the developing forebrain and cerebellar primordium, expression is restricted to proliferating neuroepithelial progenitors and cerebellar granule precursors
+Expressed in fetal brain (at protein level)
+Expressed rapidly and strongly at all stages
+The expression pattern is complex and dynamic. Maternal expression is found in a diffuse pattern throughout the blastoderm, and this pattern persists through the onset of gastrulation. More pronounced expression can be seen at tailbud stage in the anterior portion of the embryo and along the embryonic axis, and at the 16-somite stage in the midbrain/hindbrain boundary and the tip of the tail where blisters later develop in receptor mutants. At the 18-somite stage, expression appears just lateral to the midline, and as the myocardial precursors migrate to the midline, their location overlaps with this domain of receptor expression
+Expressed during meiosis and sporulation (at protein level). Present in spores (at protein level)
+Expressed from the cellular blastoderm stage on, most during gastrulation and is no longer detected by the end of germ band extension
+Has low levels of expression in young fruit but is induced late in fruit development and during fruit ripening
+Expressed in the head and tail ganglia of larval hermaphrodites
+Peak of expression 12 days after pollination
+Expressed in seeds from 1 to 4 days after imbibition
+Expressed ubiquitously from 8.5 dpc and is mostly concentrated in the developing nervous system at later stages. By 10.5 dpc, it is mainly expressed in the neural tube. At later embryonic stages (12.5 dpc and 15.5 dpc), it is predominantly expressed in the brain, spinal cord, and dorsal ganglia and weakly expressed in the hindlimb. According to PubMed:18250320, expression is restricted to the lateral neural folds, while PubMed:23332756 detects expression throughout the neural tube. Also expressed at low levels in kidney stroma and retina at 15.5 dpc
+Expressed 2 hours before the S phase and remains constant therafter
+In testis, expression levels are low in young animals and increase rapidly after 10 weeks of age
+Highest expression in early stages of retinal development with a 50-100 fold decrease from day 3 to day 19 of retina maturation
+In renewing intestinal epithelium, expression of isoforms containing segment B correlates with the onset of enterocytic differentiation
+Distributed asymmetrically after the first cleavage of the embryo: expression is higher in posterior blastomere (germline blastomere P1) of a 2-cell stage embryo than in the anterior blastomere (somatic blastomere AB) (at protein level) (PubMed:9834181). Initially present at similar levels in both daughters of P1, but persists at high levels only in the germline daughter, P2 (at protein level) (PubMed:9834181). The asymmetrical distribution pattern is seen at each of the subsequent divisions of germline blastomeres (PubMed:9834181). After the division of the final germline blastomere P4, not detectable in either daughter cell (at protein level) (PubMed:9834181). Present predominantly in the germ precursors (PubMed:9834181). Distributed uniformly in oocytes and in newly fertilized embryos (PubMed:9834181). Expressed in immature gonads of fourth stage larvae (PubMed:9834181)
+Expressed ubiquitously throughout development
+Predominantly expressed at fetal stages with highest expression in fetal liver. Also expressed in fetal kidney, intestine and lung, as well as muscle, heart and stomach
+Highly expressed in many fetal tissues, inlcuding kidney but shows markedly lower expression in adult organs. Expression in kidney is high throughout development with maximal expression occurring near birth
+Expressed in the endoderm from the 14-somite stage. Aroound 9.5 dpc, present in the ventral prepancreatic and prehepatic regions (at protein level). At 14.5 dpc, expressed in brain, stomach and gut
+Mainly expressed during the vegetative growth, the level decreased when the mycelium can differentiate and form sporangiophores
+Expressed throughout development and in adult
+Detected in germline and follicle cells (at protein level). Predominantly expressed in follicle cells where expression persists throughout oogenesis (at protein level). In germline cells, expression levels decrease as cells develop and move to the posterior region of the germarium
+Expressed both maternally and zygotically. Expressed at 10 hours post-fertilization (hpf), reach peak levels at 48 hpf and is not detectable in adult tissues. Expressed during neurogenesis between 9 and 72 hpf and in ventral endoderm region where pancreatic progenitors originate
+Expressed in the surface glial cells of the nerve cords at the larval stage (at protein level). Expressed throughout development
+Detected in adult testis from age 13 months onwards
+Detected in the tracheal system and hindgut from embryonic stage 13 onwards (at protein level)
+Expressed in emerging floral primordia and then in stamens and carpels. Expressed first in stamen primordia, then in pollen mother cells and tapetal cells and later in microspores until flower stage 11. Expressed in carpels throughout flower development from primordia to the mature embryo sac stage. Expressed in developing embryo
+Expressed in the pre-hypertrophic and hypertrophic cartilage of the embryonic growth plate
+Expressed at low levels in stage 2 nectaries. Levels then increase and expression is even throughout subsequent stages of nectary development
+Expression in the amniotic fluid increases dramatically during weeks 12 to 25 of pregnancy. Levels decrease slowly after 25 weeks
+Expression starts early during embryogenesis and is maintained through late embryogenesis and in the adult
+Expression peaks approximately 2 hours after the addition of human IgG
+Expressed from 17.5 dpc onwards
+Operon expression begins by 6 hours after starvation has initiated development and is under strong negative regulation by DevS
+Expressed in vegetative cells. Also present in dormant spores in the forespore inner membrane
+In embryos, expressed uniformly throughout the blastoderm stage and gastrulation (from stage 5). During stage 10, ci is eliminated from the posterior compartment of each segment forming 15 segmentally repeating stripes at the end of the short phase of germ-band extension
+First detected in a group of around 15 epidermal cells on the abaxial half of each ovule primordium (chalaza, outer integument initiation sites). Later present in the outer cell layer of the outer integument on the abaxial side of the ovule primordium. Confined to the chalazal end of the integument and disappears after anthesis. Also present in embryos at the globular stage
+First expressed in stigmas at low levels in flowers two days preanthesis. Accumulates rapidely the day before anthesis and stays at high levels in stigmatic tissues for several days after flower opening
+During anther development, expressed in the tapetum at the middle-stage and late-stage of pollen differentiation
+Isoform b is expressed abundantly in second larval (L2) stage. Isoform a is more abundant in embryos
+Expressed throughout development with lower levels during larval development
+Expressed in immature embryos 3 weeks after pollination, in roots and shoots of 3 day and 5 day old seedlings, and in roots of 10 day old seedlings
+Expressed on the surface of developing seeds and up to the early globular stage of embryo development
+Detected in endothelial cells in the capillary plexus, veins and arteries in the retina at 2, 12 and 17 days after birth (PubMed:21832056). Expressed at low levels in most organs and connective tissue at 13.5 dpc. Between 15.5 dpc and 18.5 dpc, strongest expression in brown fat
+Highly expressed in the proliferating cells of the vegetative shoot, root, floral inflorescence and flowers, and in rapidly growing cells
+Expressed in the developing heart by cardiac endothelial cells with a peak of expression at 12.5 dpc and a decline to low levels in adult heart
+Exhibits circadian rhythm expression
+Expressed in stalk cells late in development
+Expressed in both embryos and adults
+In vegetative organs, confined to vascular tissues of leaves and roots (PubMed:31341004). In flowers, detected in petal vascular tissues, anther filaments and styles (PubMed:31341004). In siliques, present in funiculi (PubMed:31341004). During embryogenesis, expressed from the globular stage to the mature stage in the embryo but not in the endosperm (PubMed:31341004)
+Highly expressed in gynoecium development, disappearing with maturation
+Specific to stage V sporulation
+Expressed during embryonic and larval development
+Highly expressed in filamentous form
+In the vector stage, expression starts at the L2 larval stage and continues throughout the L3 infective larval stage. After infecting the host, expression rapidly decreases and is absent from the L4 larval stage and in adults (PubMed:9233676, PubMed:18249028). Not expressed in microfilariae (PubMed:9233676)
+Expressed in primary motor neurons from early stages of their differentiation (12 hpf) to at least 24 hpf
+No expression detected at 10.5 dpc in the developing brain. At 12.5 dpc, expression is detected in the developing sentral nervous system and peripheral nervous system. At 17.5 dpc, high levels of expression are detected in a number of sites, including the dorsal root ganglia of the peripheral nervous system and the ganglion cell layer of the neural retina in the developing eye. At this stage, expression in the brain is restricted to the ventricular zone of the telencephalon, in particular in the basal ganglia and the cerebral cortex
+Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5 dpc-16.5 dpc. In the earlier stages at 9.5 dpc and 10.5 dpc, is fairly ubiquitous though with clearly elevated expression in the progress zone and lateral mesoderm of limb buds, optic and otic vesicle, neural tube, and brain. Later on at 11.5 dpc and 12.5 dpc, expression becomes more restricted and is confined to the interdigital area of limbs, dorsal mes/metencephalon, neocortex, and neural tube. Expression is seen in the eye lens from 10.5 dpc until 12.5 dpc
+Highest expression at embryonic day 11
+Expressed in both vestibular and cochlea hair cells in early developing and postnatal mice and can also be detected in the spiral ganglion cells in at post natal day 6
+Expressed during the asexual blood stage, including ring, trophozoite and schizont stages (at protein level)
+Expressed at late exponential and stationary phases, but not in the early exponential phase
+Weakly expressed in the cerebellum by 20 dpc, levels increase until 28 days after birth
+Expressed in heart as early as the 24th week of gestation
+Accumulates in adult plants, especially in rosette leaves and roots (but not in the vasculature and in tips) (PubMed:18375658). Weakly expressed in inflorescence nodes and at the base of the flowers (PubMed:18375658). In flowers, present in pollen and, at low levels, at the tips of the stigma (PubMed:18375658). In seedlings, observed in the vasculature and in the shoot apical meristems (PubMed:18375656)
+In developing panicles, highly expressed in the spikelet abscission zone (AZ) and the inner floral organs of 2 mm long spikelets. Later present at weak levels in the apiculus as well as in the palea and lemma to progressively fades out in 8 mm long spikelets
+Produced during sporulation
+Expressed from the 3-fold embryonic stage to young adult and at the larval stage in hypodermal and intestinal cells
+Expression is observed after 4 weeks of age in males only. Not expressed in females or in males castrated at 3 weeks of age whereas expression is not down-regulated in castrated adult males
+Maximally present at the middle of embryonic development and disappears by the end
+Expressed both maternally and zygotically. Expressed widely in the embryo up to 24 hr post-fertilization (hpf). Expressed predominantly in the brain, branchial arches, and liver primordium between 24 to 72 hpf. Expressed in the midbrain at 7 days post-fertilization (dpf)
+Copolarizes with BASL, YDA and MPK3 in stomatal asymmetric cell division (ACD) cells
+Expressed during the early and middle stages of seed development (PubMed:8479424). Abundant throughout plant development in the aerial part of the plant (PubMed:25333723)
+Not present in female gametophyte before fertilization. Expressed in pollen tube and at the micropylar pole of pollinated seeds
+At 8 dpc mainly expressed in the lateral plate mesoderm and the somites. Beginning at 9 dpc the lateral plate expression is clearly focused in the developing fore- and hindlimb buds. In the cephalic region, expressed in the first and second branchial arch, in the nasal process and around the otic pit. At 9.5 dpc strongest expression is observed in the mesenchyme of the branchial arches, the limbs, and the developing dorsal root ganglia. Weak to intermediate expression is found in the neural epithelium. Expression is seen in the newly formed somites in the tail bud of older embryos. During formation of the digits, expression seems to outline the surviving tissue bordering it towards the apoptotic webbing. Expression is seen in the developing outer ear and in several areas known to be regulated by intensive epithelial mesenchymal interactions, like the viscera follicles and the developing mammary glands
+Expressed during plant development. During young panicle development, highest expression is observed at P4-P5 stages followed by a gradual decline until becomes nearly undetectable at 8 days after heading. Expression is significantly up-regulated during anther development and peaks during male meiosis. Expression disappears in postmeiosis anther
+Expression is down-regulated during pregnancy and is virtually undetectable during lactation. Expression progressively increases post-lactation
+Accumulates in early G2 phase and then disappears over a period of between 1 and 5 hours post-S phase
+Expression in the kidney decreases steadily from 3 days until 6 months and then increases slightly at 15 months
+Expressed during neural and epidermal differentiation. Primarily expressed in growth-arrested differentiating cells. In the spinal cord at embryonic day 10.5, a strong expression seen in the differentiating cells of the intermediate zone at the ventral part of the neural tube and weakly in the ventricular zone. At 11.5 and 12.5 dpc, highly expressed in the intermediate zone and at reduced levels in the ventricular zone that mostly persists in the dorsal part of the neural tube. At 14.5 dpc, expressed throughout the spinal cord. In the developing epidermis, expressed in the dermis, hair follicles and in some differentiating cells in the upper layers of the epidermis
+Expression is restricted to oogenesis, early embryogenesis and the adult ovary
+Expression peaks at the G1/S phase boundary
+Pepsinogens in group I, II, and III where the predominant zymogens at late postnatal stage
+Expressed during bud growth and diappears when the flower opens
+Expressed maternally. Expression is high in early embryos but gradually decreases as development proceeds (at protein level)
+Expressed in embryo with higher expression between 15 dpc and 17 dpc
+Expressed in dark-grown seedlings and remains stable throughout the greening process. Highest expression in developing green tissues and in leaves undergoing senescence or abiotic stress, with the exception of heat shock conditions that induced a drastic reduction of expression
+During 14 dpc expression is abundant in the cerebral cortex, hippocampus, brain stem and the mitral and glomerular layers of the olfactory bulb, expression in the olfactory bulb remains evident into adulthood (at protein level) (PubMed:21945643). Expressed in proliferative layers and oligodendroglial precursor cells (OPCs) during embryonic development (14-16 dpc), in regions such as the ganglionic eminence, mamillothalamic tract, neuroepithelium, and cortical plate (at protein level) (PubMed:21945643). Expressed in migrating OPCs along the optic nerve at 16.5 dpc (at protein level) (PubMed:21945643). During late embryonic development (18 dpc) expression is abundant in pyramidal and granular cells of the hippocampus, and OPCs in the migratory pathway and embryonic fimbria of the hippocampus (at protein level) (PubMed:21945643). At postnatal day 1 (P1) expression is abundant in the corpus callosum, anterior commissure, and several nerve nuclei in the hindbrain, such as the oculomotor nucleus, the periaqueductal gray area, the facial nucleus, the colliculli, and the raphe and pararubral nuclei, as well as in the proliferative layers of the anterior subventricular zone, with expression remaining evident into adulthood (at protein level) (PubMed:21945643). A significant abundance of protein is apparent in the arcuate and posterior hypothalamic nuclei at P10, and additionally in hypothalamic OPCs, expression becomes evident in the arcuate nucleus at P15 (at protein level) (PubMed:21945643). Abundant expression throughout the embryonic brain from 14 dpc onwards with decreased expression in all areas of the brain in adulthood, however expression remains relatively abundant (PubMed:21945643)
+Expressed in mycelia but not in yeast-form cells. Expressed during plant infection
+Not expressed maternally
+Is transcribed at late phase of retinal development in the embryo, and is shut off sharply at hatching
+Required during the entire larval period for normal adult development. It is found in almost all cells and tissues throughout gastrulation and organogenesis though at a much lower level than in early syncytial stages
+In the embryo, primarily expressed in the cartilage, tooth germs and salivary gland. Expressed in the inner enamel epithelium during the cap and bell stages (14.5 dpc - 18.5 dpc), in the preodontoblasts during differentiation stage (18.5 dpc - P0) and in the differentiating odontoblasts during the early secretory stage (P2.5-P4.5). After birth, at P14, detected at low levels in the cerebral cortex, hippocampus and thalamus. In the adult brain, expression becomes weaker
+Not induced after imbibition
+Transiently expressed during embryo development. Undetected in the blastula stage embryo, induced in gastrula embryo, expressed in neurula embryo, and then down-regulated in pretailbud embryo
+Expressed during seed maturation (PubMed:15331088, PubMed:9816677). Appears in maturing seeds approximately 3 weeks after flowering and thereafter the level is maintained at a steady level till the late stage of seed maturation (at protein level). Detected in maturing seeds 2-3 weeks after flowering, progressively increasing to the maximal level in the following 2 weeks, and diminishing thereafter to a relatively low level at the late stage of seed maturation (PubMed:15331088)
+Restricted to the aggregation stage of development of D.discoideum
+Detected in the flanking ectoderm of the trunk prior to limb outgrowth. First detected in the presumptive forelimb region at 8.75 dpc, and in the presumptive hindlimb region at 9.25 dpc. Uniformly distributed throughout the dorsal limb ectoderm during the initial stages of limb-bud outgrowth (9.25 dpc for the forelimbs, 9.75 dpc for the hindlimbs)
+Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG)
+Differentially expressed in developing kidney. In 16 dpc embryos, highly expressed around the ureter and, also in all stromal elements, including the interstitial populations of the medulla and the outer layer of the cortex. In 19 dpc embryos, expression in the medulla is increased and is also found in the mesenchymal tissue surrounding the developing ureter
+First expressed at globular stage onward in the COL progenitors after the first division of the hypophyseal cell. Later observed in these cells and their descendants, mostly in direct daughter cells. Also detected in the Epi/LRC stem cells and daughters, and is retained in maturing LRC layers. Present in elongated stem cells that are about to divide
+Expressed zygotically from the end of gastrulation. Expression increases during neurula stages and is maintained at a constant level throughout tailbud stages and later development
+Expression is relatively low during development and begins to increase only postnatally, peaking at around postnatal day 50 and declining thereafter
+Expressed from the early tailbud stage (at protein level). Expressed in animal pole blastomeres of the four-cell embryo and in the neural crest and neural folds of the neurula stage embryo
+Present at 0-3 hours of embryogenesis. Maximal expression at 3-6 hours. Strong re-expression in first-instar larvae
+Expressed in developing seeds from 4 to 12 days after flowering (DAF)
+Specifically expressed in type A spermatogonia at stages IX-XI of spermatogenesis. Detected there until the cell developed into type B spermatogonia
+Expressed at all stages of development, from seedlings to adult reproductive phase, throughout the shoot apical meristem and young primordia
+Expressed throughout development from the embryo to the adult (PubMed:11032868, PubMed:11700045). Expressed in the head region of larva (PubMed:11032868)
+Not present in the maxillary first molar tooth before 18 dpc. Present at high levels in ameloblasts and adjacent cells at P7. At P14, present in differentiating pre-cementoblasts and pre-osteoblasts along the developing root surface and alveolar bone. At P28, present in cementoblastic cells in the periodontal ligament and osteoblastic cells on the alveolar bone surface (at protein level)
+Expressed in the subventricular zone and specifically in the hippocampal anlage at embryonic day 19 (19 dpc). From postnatal stages on, expressed in the hippocampus and in the entorhinal cortex. In the dentate gyrus weakly expressed in the infrapyramidal blade at P0 and at P5 expressed in the suprapyramidal blade. This expression remains unchanged during maturation. A reduced expression is seen in adult brain
+Expressed during leaf senescence but not during fruit ripening
+Expressed both maternally and zygotically. Zygotically expressed throughout embryogenesis
+Accumulates progressively in floral nectaries during maturation, reaching highest levels during maximal nectar secretion
+Detected from the third larval instar onwards, with maximal expression levels in adult flies
+In seedlings, mainly localized in meristematic tissues (e.g. shoot apical meristem SAM, root tips, and growing leaf and lateral root primordia). Present in all the vasculature and the shoot apical meristem (SAM) of the adult plant. In the root tips, strongest expression in the procambium
+Protein levels accumulate with age in postnatal renal development
+Expressed in the vascular tissues and pericycle of primary roots. Detected in the vasculature of the cotyledons, rosette leaves and cauline leaves. In flowers, localized in vasculature of petals, stigma, and stamen filaments, and, to a lower extent, in anthers and carpels. In inflorescence stems, accumulates in the vasculature, particularly in cambium, phloem, and interfascicular parenchyma cells
+Expression lasts until zygotes are formed
+Expressed both maternally and zygotically, zygotic expression is seen throughout development
+Expressed maternally and zygotically (PubMed:10380924). Expressed in the first 32 daughter cells of the MS blastomere cell, and in the 8-cell stage ABar blastomere and subsequently, asymmetrically in its descendants (PubMed:12810601). Expression is higher in the anterior daughters of dividing cells, but lower in the posterior daughters (PubMed:12810601, PubMed:10380924, PubMed:19386265, PubMed:17567664, PubMed:17296929). Expressed asymmetrically in vulva precursor cells P5.p, P6.p and P7.p at L2 larval stage and in their descendants (PubMed:15649465). Expressed asymmetrically in somatic gonadal precursor cells Z1.p, Z4.a, Z1.a and Z4.p (PubMed:25569233). During M-lineage cell fate specification, expressed evenly from 1-M to 4-M stages followed by asymmetric expression in anterior cells at the 8-M, 16-M and 18-M stages (PubMed:19427847). Expressed asymmetrically in seam cells at larval stages L2 and L3 (PubMed:31740621). Transiently expressed asymmetrically in the embryo in the SMDD/AIY neuron lineage; asymmetry of expression is lost at the 1.5-fold stage (PubMed:19386265, PubMed:26073017)
+Expressed in germinal vesicle (GV) stage and MII-stage oocytes and zygotes. Expression then decreases from 2-cell stage to blastula (PubMed:24357321). Widely expressed at 8.5 dpc, 9.5 dpc, 12.5 dpc, and 19.5 dpc (PubMed:10574459)
+Increases dramatically in tissues undergoing rapid expansion, particularly in anthers, ovules, and petals
+Highly expressed in the late phase of adipocyte differentiation (at protein level)
+Probably expressed only during sporulation
+Expressed at all stages; increase in expression in the culminating fruiting body and during starvation
+Expressed from embryonic stage 12 through to adulthood
+Exclusively expressed in the mature egg cells before fertilization
+Only detected in fetal tissues
+Oscillates during the cell cycle, being lowest at G1 and highest at S phase (at protein level)
+Expressed ubiquitously during embryogenesis with higher levels found from 9-12 hours after egg laying. Low levels are found in larvae and adults
+Highly expressed in young leaf and floral tissues but not expressed in mature tissues (at protein level)
+Mainly in late larvae
+Extensive expression found in 8-day embryos, fell drastically in 10-day embryos and virtually absent in 17-day embryos. Expressed during specific stages of spermatogenesis, with the highest levels in stage 6-8 round spermatids after 3 weeks of age
+Expressed abundantly in early embryogenesis. Moderate expression is found in larval and adult stages
+Expressed in the embryo (at protein levels) (PubMed:3095323). Expressed at high levels in eggs and to a lesser extent during embryonic development (PubMed:10930405). Expressed at all larval stages and at higher levels in adults (PubMed:10930405)
+Highest level of expression is detected at embryonic day 16. Alternative splicing isoforms have different spatiotemporal expression patterns. In cochlear cultures at the equivalent of postnatal day 3, isoforms belonging to the CD1 (isoforms 1 through 9) and CD3 (isoforms 18 through 20) groups are highly expressed in hair bundles in the basal coils and moderately in those in the middle of the apical coil; they are hardly detectable in those at the apical end of the apical coil (at protein level). At the base of the cultured cochlea, in the more mature hair bundles, CD3 group isoforms are restricted to the tips of the shorter stereocilia in both inner and outer hair cells. By contrast, at the same stage, isoforms belonging to the CD2 group (isoforms 10 through 17) are highly expressed in hair bundles in the apex of the cochlea and, at lower levels, in those in the middle of the apical coil; they are hardly detectable at the base of the cochlea (at protein level). In mature hair bundles, CD1 group isoforms are distributed fairly evenly along most of the length of the stereocilia on auditory hair cells, whereas they are concentrated toward the upper third of the hair bundle in vestibular hair cells. In both the auditory and the vestibular organs, these isoforms are excluded from a region at the very tip of each stereocilium (at protein level). In contrast, CD2 group isoforms are undetectable in adult cochlear hair cells (at protein level). These isoforms are expressed in the entire hair bundle of the immature cells in the sensory epithelium of the early postnatal vestibule and only in the kinocilium in the more mature hair bundles (at protein level). CD3 group isoforms are detected in immature vestibular hair bundles, concentrated toward the tip of each stereocilium, as early as 15.5 dpc. They also localize to the tips of the shorter stereocilia in the mature vestibular hair bundles and are not detected at the tips of the stereocilia in the tallest row (at protein level)
+In embryos, present in cells relevant for root initiation and later in vascular tissues. At the globular stage, accumulates in cells adjacent to the hypophysis (extra-embryonic cell specified to become the founder cell of the primary root meristem) (PubMed:20220754). Expressed at preprocambial stages first in wide domains, and later confined to sites of vein development. In young seedlings, first observed in the central region of leaves primordia, and later strongly expressed at sites of midvein, first and second loops, and higher-order veins (PubMed:20563990)
+Strongly expressed in developing ovules (PubMed:28500265). During embryogenesis, expressed from the globular stage to the mature stage in both the embryo and endosperm (PubMed:31341004). From the torpedo to the mature embryo stages, strongly expressed in the provascular cells of the developing hypocotyl and in the shoot apical meristem (SAM) (PubMed:31341004). In leaves, strongly expressed in vascular tissues and stomata (PubMed:31341004). In roots, accumulates in the stele and at lateral root formation sites (PubMed:31341004). In flowers, observed in anthers and pistils (PubMed:31341004). In siliques, high levels in seedpods (PubMed:31341004)
+Expressed in the inner pericarp of developing fruit at 117 days after flowering (DAF)
+Expressed throughout embryonic, larval, pupal, and adult development. Expression throughout the embryo is followed by a restricted pattern of mesodermal expression that is later confined to the visceral mesoderm, gonads, gut, and salivary glands
+Is equally expressed in juvenile and adult (male and female) frogs
+Onset of expression correlates with the initiation of axonogenesis in 16-36 hours embryos
+Expressed in liver, heart, kidney, ovary and testis, at 16 dpc, P6 and P16
+Expression is enriched in early embryos, decreases during larval stages, and rises again at pupal stages (PubMed:29555755). Strongly expressed during the maternal-to-zygotic transition, a time where N6-methyladenosine (m6A) methylation of mRNAs is decreasing (PubMed:29535189)
+In flowers, expressed in the pollen and growing pollen tubes (PubMed:27872247). During microspore development, observed expressed from tetrad to tricellular pollen (PubMed:27872247). Also present in young siliques and developing ovules (PubMed:27872247)
+Accumulates throughout the embryo and in endosperm (PubMed:16113228). Expressed throughout the plant life cycle, from embryogenesis to seed set. Accumulates in the shoot apex. In roots, confined to the vascular system. In anthers, observed when the filaments start to elongate, and remain expressed in later stages. Constitutively expressed in gynoecia (PubMed:22411811)
+Extensively expressed in guard mother cells and young guard cells of cotyledons and leaves during stomatal formation
+Present in growing cells but is undetectable after 4 hours of starvation
+Expressed at 9.5 dpc, with a pattern of expression that shows restricted localization to the myotome of somites. By 13.5 dpc, expression is observed within intercostal and back muscles. At 14.5 dpc and 15.5 dpc, expression is observed in tail myotomal muscles, and in intervertebral and back muscles. Hybridization was also detected within limb muscles. This pattern of expression was maintained at least up until 17.5 dpc. No localization within the heart
+In anthers, expressed in endotheciums and tapetums
+Not expressed until 29 dpc. Expressed in parallel with synthesis of spermatids
+Detected starting at 10.5 dpc in the ectoderm and superficial mesoderm surrounding the caudal part of the tail region. At 12.5 dpc detected in dorsal root ganglia, surface ectoderm surrounding the caudal part of the tail, the inferior wall of the genital tubercle, developing liver, in Rathke pouch and in condensing mesenchyme forming the roof of the skull. At 14.5 dpc detected in the perichondrial region of the craniofacial, axial, and appendicular skeleton. By 16.5 dpc expression is much lower throughout the embryo, and is not detectable by 18.5 dpc
+Present in aerial but not submerged hyphae, persists as hyphae differentitate and form spores; present at the outer surface of these structures (at protein level)
+Expressed in both unfertilized and fertilized eggs during preimplantation development (at protein level) (PubMed:24268775). Detected in all blastmeres of morulae at 3 days post-coitum (dpc) (at protein level) (PubMed:24268775). Localizes to the pluripotent inner cell mass (ICM) of blastocysts at 4 dpc (at protein level) (PubMed:24268775). Expressed in many fetal tissues (PubMed:11113208). High expression in fetal heart and kidney (PubMed:11113208). Weak expression in fetal liver (PubMed:11113208)
+Not expressed in vegetative stage. Expressed maximally at 6 hours of development. Not expressed after 12 hours
+Expressed at highest levels in vegetatively growing cells. Expression declines during development
+Expressed in brachial arches, maxillary process, fore and hind limb buds and in the developing gastrointestinal tract of day 10 embryos
+Expression is slightly increased in naive B-cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division
+Abundantly expressed during embryonic development, especially in the developing central nervous system and sensory organs, cranial and spinal ganglia and endoderm of foregut and hindgut. At 10 dpc, detected along the entire neural tube, the mid- and hindbrain floor, the central canal of the brain vesicles, spinal cord, lung mesenchyme, the trabecular layer of the heart ventricles, endoderm and endodermally-derived structures such as tracheal epithelium and liver. At 11 dpc, expressed in the brain vesicles, along the spinal cord, myotome, migrating muscle progenitor cells in the body wall, cells of the genital ridge, spinal ganglion, liver, cerebellar primordium, basal cells of the neuroepithelium of the mesenchephalic flexure, collections of cells in the pons, Rathke's pouch, spinal and cranial ganglia and the floor plate, retina, lens, optic stalks and the neural crest-derived mesenchyme in the anterior eye segment. During eye development, expression restricted to the retinal pigment epithelium of the posterior hemisphere at 18 dpc, with expression levels increasing postnatally to P16
+Levels are low until the penultimate larval instar, and peak in feeding larvae of this instar. Expression decreases again at the molt to the last larval instar. Levels rise rapidly after ecdysis when the larvae initiate feeding and reach a maximum in slowly mobile prepupae at the end of cocoon spinning. There is then a ten-fold drop which coincides with the start of silk gland degeneration
+During anther development, expressed in tapetal cells of immature anthers, but not in mature pollen (PubMed:1463854, PubMed:20610705). Weakly expressed in microspores from stage 9 to stage 11 of anther development (PubMed:20610705)
+Expressed early in development
+Expressed throughout early embryonic development
+Expressed at the early stage of berry development and then decreases toward the ripening stage (Ref.1, PubMed:16169968). Up-regulated after flowering (PubMed:16169968)
+During embryonic development, expressed at high levels in anterior epithelial lens cells at 14.5 dpc (PubMed:10885750). At 16.5 dpc, expressed in osteoblasts surrounding newly formed trabecular bone (PubMed:19232401). At postnatal day 2, detected in most osteoblasts and lining cells (PubMed:19232401). By postnatal week 4, is detected in fewer osteoblasts, but remains present in lining cells (at protein level) (PubMed:19232401)
+Expressed at the embryonic comma stage and throughout larval and adult stages
+In males, expressed in several sex-specific cell types during larval development and in the adult, including the A-type ray sensory neurons, ventral male-specific muscles, and unidentified neurons of the male posterior ventral nerve cord (PubMed:12231628). Transiently expressed during larval development in the hindgut (PubMed:12231628)
+Detected in fetal lung
+At late embryonic stages, highly expressed in hindgut. At larval stages, expression detected in fat body, anterior midgut and salivary gland
+Plasmodium specific alpha 1-tubulin
+Expressed in endosperm during early stages of seed development. Strongly induced at heart stage of embryogenesis
+Expressed throughout development, with slightly higher levels of expression in 0-4 hour embryos, larvae and adults
+During female gametophyte development, preferentially expressed in the gametic cells
+Initially detectable in embryos with a localization to the base of the developing cotyledons near the SAM. Expressed during vegetative development in young leaf primordia and at the base of the rosette leaves on the adaxial side. Expressed during reproductive development in young floral buds, and at the base of the sepals and petals
+Maternally expressed in early embryogenesis with high expression until blastoderm. At the cell formation stage, strongly expressed near the basal part of the cell layer underlying the surface. During germband extension and stomodeal plate formation, expressed in the ventral head and trunk ectoderm, as well as in cells near the cephalic furrow and in the invaginating hindgut and midgut primordia. After germband retraction and delamination of neuroblasts at stage 13, expressed in subsets of cells in all neuromeres of the CNS including those of the supraesophageal and subesophageal ganglia. In later embryonic stages expressed in cell clusters throughout the supraesophageal ganglion, with pronounced expression also seen in the subesophageal ganglion. In the ventral nerve cord (VNC), expressed in two broad longitudinal stripes located laterally, and weakly expressed in some midline cells. Also expressed in some sensory head organs of the peripheral nervous system (PNS), most probably the Bolwigs organs and/or the dorsal organs. Expressed in the developing larval neuromusculature, muscles and neuronal axons. Enriched in neuromuscular junctions throughout the muscles of the body wall. Enriched in punctate domains of synaptic boutons and excluded from interbouton axonal connections. Colocalizes with the synaptic vesicle pools
+Unlike the rat protein, which is an acute phase protein, this protein is always in circulation at high levels
+Expressed throughout embryogenesis with higher expression in the cotyledon primordia at heart stages
+Expressed in flower buds and detected in open pre-anthesis flowers, flowers after anthesis and in early stages of fruit onset
+Expressed in mature metaphase II (MII) stage oocytes (at protein level) (PubMed:36070373). In B-cells, expression increases as a function of differentiation and peaks on memory B-cells
+In 9 dpc embryos it is expressed in regions corresponding to the neural tube, notochord and somites. Through the neural tube, it is expressed in the ventricular zone and in migrating neuroblasts. Also expressed in the notochord and specific regions of the somite. Strongly expressed in the myotome (future skeletal muscle) of the somite. In addition to the neural tube, it is also expressed in the ventricular zone and migrating neuroblasts throughout the embryonic brain. Prominent expression is detected in the yolk sac and embryonic heart. Within the yolk sac, it is expressed in both the epithelial and endothelial layers (blood vessels) but absent from the blood islands. In the heart, it is detected in both the atrial and ventricular chambers. In the ventricular myocardium it is present in both the endocardium and myocardium. Also expressed in the cardinal vein, aorta, digestive tract, and pharyngeal arches
+Expressed at late stages of pollen development. Up-regulated during pollen germination and pollen tube growth
+Expressed in seedlings and mature plants
+Detected in one-cell-stage embryos, suggesting maternal expression. Detected in blastomeres at 2.5 to 4 hpf. Ubiquitous in embryos from 6 to 12 hpf. At 24 hpf, expression is ubiquitous, with higher levels of expression in the region of the brain and eyes. At 48 hpf, predominantly expressed in the brain area, but also detected in heart and fins
+Expressed from early G2 phase and increases to reach a peak at mitosis
+Increased expression during optic nerve regeneration
+Accumulates early during embryogenesis, but repressed late in seed development (PubMed:2485233). Progressive level increase from pod to full-size seed growth (PubMed:22245912)
+Expressed both maternally and zygotically. Expressed at all oogenic stages
+Expressed in the testicular cords at 13.5 dpc
+Found in the large cell variant (LCV) stage, very little is present in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs
+In the developing brain, expressed at low levels prior to 15 dpc. Expression increases in the early postnatal stages, peaks at P16, and decreases in adulthood
+Accumulates in the pollen tube nucleus during pollen tube growth through the pistil
+Highly expressed in the yolk syncytial layer during embryonic (starting at the gastrula stage) and early larval development, an extraembryonic structure implicated in embryonic and larval nutrition
+Expressed in embryo at 7 dpc. Expressed in the brain vasculature at 12 up to 16 dpc, whereupon it disappears
+Accumulates in kiwifruit during ripening
+Expressed in a graded pattern in the closing neural tube. Subsequently becomes restricted to the dorsal neural folds and migrating neural crest
+In the placenta, in the first trimester of gestation, low expression in the cells surrounding villi both in the inner layer of the cytotrophoblast and in the outer layer of the syncytiotrophoblast (at protein level). In the third trimester of gestation, very strong expression in the outer layer forming the syncytiotrophoblast and lower in the cytotrophoblast (at protein level)
+Expressed in embryonic and early larval stages and in adult animals
+Expressed in embryos at 12 weeks of age
+Highest levels in embryos and lower levels in larvae and adults
+During gastrulation, expression is ubiquitously detected throughout the embryo. During development is detected in epithelial cells, blood precursor cells and developing vessels. By 48 hpf, weaker expression is still detected in epithelials cells
+Expressed during the larval L1 to adult stages, with little or no change in transcript levels (PubMed:24569038). Expressed in several head neurons during L4 larval stage in hermaphrodites (PubMed:24569038)
+Expressed from the comma stage of embryogenesis, during all larval stages, and in adults (PubMed:9685599). In males, highly expressed in PHC sensory neurons during the L4 larval stage (PubMed:28065609)
+Expressed throughout development. Highly expressed in somatic nuclei, as well as in immature germ cell and oocyte nuclei
+Expressed at all developmental stages from embryos undergoing morphogenesis to gravid adults (PubMed:23682709). Broadly expressed in embryos and early larvae, but expression decreases in late larvae and adults (PubMed:33950834). Expressed in seam cells during larval development (PubMed:33950834). Expressed in DD GABAergic motor neurons in L1 and L2 stage larva (PubMed:33950834). During larval stage L1, expressed in the pharynx and in intestinal cells (PubMed:22342905). Expressed most strongly during mid-to-late intermolt periods (at protein level) (PubMed:23682709)
+At 60 hours post-fertilization, expressed in the mesenchyme of the fin field
+Expressed in the growing regions of roots, coleoptiles, and internodes
+At 8.0 dpc, present in the left-right organiser (LRO) node, with enrichment in crown cells compared to pit cells (at protein level)
+Detected in the yolk sac of the early embryo and in erythrocytes from fetal umbilical cord blood. Detected at low levels after 10 weeks of gestation. Hemoglobin Portland levels are increased in fetuses with homozygous alpha-thalassemia, but it constitutes only a minor proportion of total hemoglobin and its levels decrease steadily after 10 weeks of gestation. Hemoglobin Portland-2 is detected in blood from still-born neoneates with homozygous alpha-thalassemia (at protein level)
+Expressed in neuronal progenitors residing in the ventricular and subventriculare zones and in postmitotic neurons in the cortical plate of the cerebral cortex at 15 dpc. Expressed in granule cell precursors within the dentate migratory stream of the hippocampus at 19 dpc (at protein level)
+Expressed during sporulation in mother cell compartment
+Expressed from days 14 to term of pregnancy
+Expressed throughout embryonic, larval, pupal, and adult stages, with some decrease in the late embryonic stages. The expression is uniform in unfertilized or just fertilized eggs, suggesting maternally deposited mRNA. At blastoderm stage, expression pattern shows stripes, that are reminiscent of many pair rule genes pattern
+Observed in all larval stages
+Expressed during early-mid embryogenesis, particularly in the inner cell mass at 3.5 dpc, in epiblast at 6.5 dpc, and at later stages in ectodermally derived tissues such as the rostral surface ectoderm (PubMed:16423343). Expressed in embryonic stem cells, epiblasts of 6.4 dpc embryos and primordial germ cells (PGCs) (PubMed:28059165). High expression levels in PGCs of 8.5 dpc embryos decrease over embryogenesis (PubMed:28059165). Up-regulated during prepupertal testis development (PubMed:15225875)
+Maternally expressed
+Expressed both maternally and zygotically. Expressed in the nucleus during the G2 phase of primary spermatocytes at stages S3-S4. Distributed between the nucleus and the cytoplasm in G2 phase of primary spermatocytes at stage S5. Localized in the cytoplasm in G2 phase of primary spermatocytes at stage S6. Remains dispersed throughout the cell until the completion of meiosis when it becomes restricted from nuclei of onion-stage spermatides
+Expressed specifically in embryos, both zygotic and somatic. Present at low levels in globular embryos. At the heart-stage, accumulates throughout the peripheral regions of the embryo and in the mature torpedo embryo expressed in the meristematic regions
+Present during vegetative growth at low level (at protein level) (PubMed:19542306). The level increases throughout meiosis and reaches its highest during sporulation (at protein level) (PubMed:19542306)
+Expressed throughout development, although expression is low in pupae. At late developmental stages expression becomes pronounced in muscles and the nervous system, particularly within the intersegmental nerve b (ISNb)
+Expressed in developing caryopsis at 5 to 15 days after flowering. Expressed exclusively in the endosperm at 5 to 10 days after flowering
+At stage 12.5 dpc, expressed at high level in the developing liver and kidneys (PubMed:11948190). Expressed at higher level in the genital ridge and the spinal ganglia (PubMed:11948190). At 18.5 dpc, preferentially expressed in the thymus and in regions of the nervous system (PubMed:11948190). Within the developing trunk, preferential expression persisted in the liver and became restricted to the cortical region of the kidney, spleen, adrenal gland, and to stomach and intestinal epithelia (PubMed:11948190). From 14.5 dpc to 18.5 dpc, as well as in the adult, expressed at the highest level in thymus (PubMed:11948190). Expression is particularly high in the subcapsular zone of the thymus where immature lymphocytes proliferate (PubMed:11948190). Expressed at high level in the seminiferous tubules of the developing testis (PubMed:11948190)
+Expressed principally in the later stages of embryogenesis prior to dehydration of the grain
+Higher expression level in adult testis as compared to 6-week-old fetal testis
+Expressed ubiquitously at 7.5 dpc and 8.5 dpc, with especially high levels in the extraembryonic ectoderm (PubMed:18701545). Expressed strongly in head from stages 10.5 dpc to 12.5 dpc (PubMed:23071813). In fetal brain, shows highest expression levels at stage 13.5 dpc with low levels thereafter (PubMed:23071813). Detected in neural stem cells of the neocortex at stage 12.5 dpc (PubMed:23071813)
+Highly and constitutively expressed throughout development. However, the ratio of soluble to insoluble protein changes during embryogenesis. Additionally, the distribution changes from a largely cytoplasmic distribution in the cleavage stage embryo to a predominantly nuclear and/or perinuclear location at blastula and gastrula stages
+Constant levels of expression during germination and throughout the year
+During seed development, highly expressed from 35 to 55 days, the period of fast increase of seed oil accumulation
+Very highly expressed seven days after implantation, when gastrulation and neurulation occurs. Expression decreases 11 days after implantation, when organogenesis is being completed, and remains rather low up to late developmental stages
+Expressed in adults within 6 hours after induction and continued to accumulate over 7-10 days
+Expressed at 14.5 dpc in liver, lung and brain
+Transcripts are expressed in gastrulae, early and late planulae, metamorphosing planulae, and primary polyps
+Expressed at higher levels in embryonic brain (embryonic days 12-14) than in newborn or adult
+One of the major proteins synthesized by wheat embryos during the very early stage of germination
+Expressed both maternally and zygotically. Distributed throughout the blastoderm at the blastua stage but becomes confined to the future ectoderm by the shield stage. Expressed in the presumptive neuroectoderm at the 75-80% epiboly stage. From the tail bud to the 3-somite stage, expressed throughout the neural plate, except in the anterior margin. At the 12- to 25-somite stage, expressed broadly in the central nervous system
+It is broadly expressed throughout the epithelium of the otic vesicle at embryonic day 10.5 dpc, but it is absent from the surrounding mesenchyme. High expression is detected in sensory and non-sensory epithelial progenitors during cochlear and vestibular morphogenesis, although the level is weaker at later stages of inner ear development
+Detected from 7.5 dpc through birth. At 8.5 dpc, predominantly expressed in the epithelium of the foregut diverticulum, the cephalic mesenchyme, the allantois, and in the myocardium and endocardium of the heart. At 9.5 dpc, prominent expression is detected in cephalic, foregut and periaortic mesenchymes, the septum transversum and the cardiovascular system. Also present in the atrial and ventricular endothelium and the myocardium of the atrioventricular canal region. By 10.5 dpc, highly expressed in endothelial cells in the atrioventricular canal and outflow tract that transform into mesenchymal cells and invade the underlying matrix. Later, expressed by mesenchymal cells during elevation of the secondary palate and by hypertrophic chondrocytes within epiphysial growth plates
+Expression starts at the end of the exponential phase and peaks two hours into sporulation. There is no enzyme activity in spores
+Strongly up-regulated during adipogenesis
+First expressed at 8.2-8.5 dpc of embryo development in the anterior head mesoderm and developing pharyngeal pouches. Expression in the developing limb begins at 11 dpc and is more pronounced dorsally. It progresses into the developing phalanges at 13.5 dpc. In the developing inner ear detected in the otic placode and the surrounding surface ectoderm at 8.5 dpc. Expression became prominent at the invaginating otic pit and the nascent otic vesicle at 9.5 dpc. At 10.5 dpc, expression was limited to the ventral half of the otic vesicle. Subsequently, the expression became gradually restricted to the cochlear region at 11.5 dpc and 12.5 dpc. At later stages detected exclusively in the cochlea at 14.5 dpc, and the expression in the cochlear duct persisted in the neonate. In the developing kidney, is expressed in the uninduced metanephric mesenchyme at 10.5 dpc and in the induced mesenchyme around the ureteric bud at 11.5 dpc. At 17.5 dpc to P0, expression becomes restricted to a subpopulation of collecting tubule epithelial cells
+Expressed in the floor plate throughout the period of commissural axon pathfinding (PubMed:10704386). In myogenic progenitor cells, highly expressed during early development (11.5 dpc) and progressively repressed as developments proceeds (PubMed:27446912)
+From neonate to weaning
+Both isoform 1 and isoform 2 are expressed postnatally in the inner ear. Expression increases from P0 to P30 in both cochlear and vestibular tissues; at all time points, isoform 2 is expressed at several-fold higher levels than isoform 1. At P14, in the organ of Corti, detected along the length of stereocilia of hair cells, particularly in the upper half. Also observed in the microvilli on the apical surface of the hair cells. More abundant in the stereocilia of inner hair cells than in those of outer hair cells (at protein level). In the vestibular sensory epithelium, localizes within the hair cell and supporting cell bodies in the saccule and utricule. Not detected in vestibular hair bundles (at protein level)
+Expressed in the retinal outer nuclear layer and the inner nuclear layer at postnatal day 10
+Expressed in the dorsal and basal telencephalon, in a subpopulation of proliferating neuroblasts, early in development (at least from 11.5 dpc)
+In P3 leaf primordium, expressed ubiquitously in the L1 layer and in the inner cells at lower levels. Not limited to the developing stomata until the last cell divisions
+Most abundant in early embryo, pupa and adult gonads (at protein level). In testis, expressed in mitotically proliferating spermatogonia and early primary spermatocytes with levels decreasing as spermatocytes mature and no expression in postmitotic stages
+Expressed during the late stages of both fruit ripening and leaf senescence
+In embryos, from stage 14 till stage 17, expressed in epidermal cells, tracheal system and denticle belts (at protein level) (PubMed:7851790). In larva and in early pupa, expressed in brain cells along the ventral midline, in cell bodies in the cellular cortex of the ventral nerve cord, in cells contributing to the perineum around the cerebral hemispheres and in axons of the longitudinal connectives of the central nervous system (CNS); at low level, expressed throughout the antennal disk (at protein level) (PubMed:7851790, PubMed:8817456). In pupae, expressed in pupal appendages and body epidermis, in the proboscis and pseudotrachea (at protein level) (PubMed:8817456). Expressed in embryos; from stage 11 until the end of stage 13 expressed in small cells along the midline of the central nervous system; at state 12, expressed in the epidermis; from stage 13 onwards, expressed in the epidermal cells in particular in the anterior border of each segment; from stage 14-17, detected in the cells of the tracheal system (PubMed:7851790). Detected in larva and pupa, but not in adult flies (PubMed:7851790, PubMed:8817456)
+In spikelets, expressed in paleas, lemmas, filaments and anthers, especially in tapetums
+Present at high levels in growing cells but decreases dramatically during the early hours of development
+Detected at the 1-cell embryo stage, probably due to inheritance of maternal transcripts. At the 50% ebiboly stage, detected in dorsal forerunner cells. At the 3-somite stage, found in Kupffer's vesicle. At the 8-somite stage, expressed in the pronephros, the floorplate of the neural tube, and otic vesicles. Expression in the pronephros continues to the 24-somite stage
+Expressed throughout development. Low expression during 48 hours after imbibition and then increases
+Level is low in vegetative cells, increases after starvation, peaks between 5 and 10 hours, and then decreases. Aggregation territories and streams form after 5 to 8 hours of starvation. This pattern of accumulation indicates that cnrN mRNA is present when aggregation territories and streams are forming
+Expressed in developing neural retina and embryonic brain tissue
+First detected in the developing male gonad before overt testis differentiation. By 12.5 dpc, expression is restricted to the developing testis cords and its expression is not germ cell-dependent. No expression seen in female gonads between 10.5 and 14.5 dpc
+Expressed in a patchy pattern during embryogenesis
+In brain, not abundant during the early stages of neurogenesis. Expression increases during cytogenesis followed by a rapid decrease towards the end of cytogenesis. Undetectable at 16 dpc. In retina, expression is detected at 4 dpc and 6 dpc, and becomes scarce by 8 dpc. Not detected in the mature retina
+Expressed in a stage specific manner during murine ontogeny. Not detectably expressed in adult tissues
+Expressed during the entire cell cycle with at least a threefold increase when cells develop competence
+Specifically expressed in pstA cells. Expression is not detected in pstO or prespore cells
+Expressed at all stages of spermatocyte meiosis
+Expressed in 2-week-old seedlings, in the early stages of development
+Expressed at 10.5 and 14.5 dpc
+Detected primarily in the epidermal cells of the segmental grooves during germ-band retraction (7-9 hours after egg laying)
+Expressed at the onset of somatic embryogenesis
+Expressed from the one-cell stage of embryogenesis onwards
+Levels in the endometrium increase as pregnancy proceeds, reaching maximal levels around day 70 and then remain relatively constant in late gestation (days 70-110)
+Initial onset of expression in the pancreas is at 12 dpc and prominent expression is detected at 14 dpc
+Expressed at the flowering stage
+Expressed in the G2/M phases and disappears at the anaphase of mitosis
+Expressed during growth and throughout development. The expression level is developmentally regulated. It reaches a maximum at the monut stage
+Expressed during stages 12-15 of spermiogenesis
+Meiosis-specific. Highly expressed in meiotic prophase cells, low expression persists in spermatids
+Highly expressed in the anther during meiosis and then gradually decreases after meiosis. Predominantly expressed during the cytological substages of meiotic prophase I from leptotene to pachytene peaking in zygotene. From stage 7 to stage 9, detected in both the tapetum and male meiocytes of the anther
+Expressed in cortical cells containing arbuscules of mycorrhizal roots upon arbuscular mycorrhizal (AM) symbiosis with AM fungi (e.g. Gigaspora gigantea, Glomus versiforme and G.intraradices)
+Expression of both isoforms is found in 1 week-old rats. Expression increases exponentially up to 4 weeks but after this time there is no further increase up to 16 weeks
+Dynamic expression in the presomitic mesoderm (PSM). At 8.5 dpc, expressed in two bilateral domains: rostral and caudal stripes. The rostral bands are located posterior to the newly formed somite, while the caudal bands extend to the most caudal tip. During 9.0 dpc-12.0 dpc stages, again specifically expressed in two domains of the PSM
+Higher levels are found in third-instar larvae and in adults
+At 15 dpc highly expressed in skeletal muscle and heart
+Maternal transcripts are ubiquitous throughout the embryo during early development. By the 12-somite stage, expression becomes concentrated in the developing ears and this persists through the 18- to 20-somite stage. Transcripts are also present in the brain, neural tube and pronephric ducts
+Expression detected 24 hpf (hours post fertilization), in developing hindbrain, most abundant in rhombomeres 2 and 3. Neural expression peaks at 48 hpf, at which point transcripts are found in the hindbrain, rhombic lip, and optic precursors. The exocrine pancreas represents a population of cells encircling the embryonic islet. At 72 hpf, expressed throughout the endodermal region corresponding to the exocrine pancreas. Expression is restricted to the exocrine pancreas following an early period of transient neural expression. Positive exocrine precursors and insulin-positive endocrine elements are both temporally and spatially segregated during embryogenesis
+First detected in testis 17 days after birth when pachytene spermatocytes are seen in testes. Expression remains high during the first three weeks after birth and in adults (at protein level)
+Detected at low levels during embryogenesis. Strongly up-regulated during the first days after birth. Levels are increased on the first day after birth, and culminate three days after birth. Detected at low levels four days after birth, and throughout the remaining life span
+Expressed in embryo during the latest stages of seed maturation
+Expressed maternally and zygotically. Expressed in the central cell before fertilization, and in the endosperm after fertilization, then decreases before the time of endosperm cellularization but continues in the chalazal cyst
+Expressed throughout development; strongest in larvae and adults (PubMed:12218185). In larvae, expressed in trachea, brain, gut, fat body and Malpighian tubules (PubMed:30110323)
+Expressed in prestalk pstA and pstO cells in the slug stage. Preferentially restricted to pstO cells during culmination. Expression in the prestalk cells is reduced in dmtA-null cells
+First expressed at mid-gastrulation
+Found in most early fetal tissues but not in the corresponding mature tissues
+Expressed in the lens during embryonic development. Predominantly expressed in the anterior lens epithelium but with some expression posteriorly. Not expressed in brain in embryos
+It is present but the disulfide bonds are reduced in reticulate bodies (RBs)
+First expressed prior to myogenic differentiation, expression continues throughout embryonic and larval development and is most abundant in embryos. It is present in decreasing amounts throughout development and a low level is found in the adults (PubMed:7925019). Expressed in distal tip cells (DTC) until L4 larval stage (PubMed:24346701)
+Isoform Rpn10E is expressed only in the embryos
+Expressed in the G1/S phases
+Expressed in embryos, L4 larvae and adults. Expressed to a lesser extent between L1 and L3 larval stages
+Peak of expression 36 to 48 hours after imbibition
+Synthesized in G1 as well as in S-phase
+Expressed from embryo to adulthood
+Expressed weakly in early larvae, levels of expression increase in larval stage 4 and adult stages when germ cells are continually proliferating
+First observed in roots and cotyledons of young developing seedlings. Later confined to root tips, vascular tissue around the shoot apex, and in young leaf primodia. In flowers, detected in the stamens and at the senescence region of developing siliques
+Present in the placenta, brain and liver during embryonic development (at protein level)
+Widely expressed throughout development in both males and hermaphrodites
+Detected in the fetal ovary and testis (PubMed:20339383). Detected in the testes as early as 6 days after birth, expression increases during the first wave of spermatogenesis (PubMed:19805151)
+Ripening fruit
+Expressed during late differentiation of the epidermis
+Highly expressed at day 7 of embryonic development. Detected at lower levels throughout the later stages of embryonic development
+Expressed in stage VI primed oocytes (at protein level)
+In embryos, expressed mainly in neuronal precursors but detected also in cells lining the gut and Garland cells (at protein level) (PubMed:20152183, PubMed:27510969, PubMed:1720353, PubMed:1540176). Expressed during embryogenesis in different cells of the central and peripheral nervous system including neuroblasts and ganglion mother cells (GMC) (PubMed:1720353, PubMed:1842358)
+In larvae, transcript is enhanced 4 hours after the bacterial infection, increases up to 12 hours post inoculation and declines by 24 hours and by 30 hours returns to background levels. In adult female, expression is evident by 18 hours after infection. Constitutively expressed in both early and late pupae
+During embryonic development it is expressed in both hematopoietic and nonhematopoietic tissues
+Expressed at both slug and early culmination stages
+Detected at postnatal day 2 and 4
+Is produced during infection of the human host
+Expressed zygotically from the beginning of gastrulation, with expression increasing at stage 12. Expression then persists until stage 35 and declines afterwards
+Accumulates in the immature tracheary elements of rosette leaves. Expressed in differentiating vasculature of the root, the hypocotyls, and the flower filaments, as well as in the anthers and the inner subepidermal layer of mature siliques
+Expression increases strongly along the fruit-ripening stages, with maximal expression observed in fully ripe red fruit
+From 8.5 to 14.5 dpc detected in nervous tissue. In the brain detected at 8.5 dpc within the prospective hindbrain, but not within the developing forebrain or midbrain. At 9.5 dpc expressed within the ventral prosencephalon, hindbrain and forebrain. Expression within the forebrain neuroectoderm flanked the optic vesicle with rostral and caudal restrictions. In addition, dorsal and ventral expression domains were observed within the hindbrain. At 10.5 to 12.5 dpc detected in the dorsal mesencephalon, in addition to the telencephalon and hindbrain. At 14.5 dpc visible in the olfactory bulbs. Detected from 9.5 to 12.5 dpc in the dorsal neural tube with the highest expression near the hindbrain. At 9.5 and 10.5 dpc detected in cells located in the dorsal and ventral neural tube and dorsal root ganglia. Detected during the development of the optic and the auditory systems. At 10.5 dpc, a small ring of ocular staining was observed suggesting expression in the lens pit. At 10.5 dpc expressed in the developing lens epithelium and in the mesenchyme surrounding the retina. However, expression in the lens placode ectoderm was not detected, suggesting that DACH2 is activated after lens vesicle formation. Low levels of expression could also be detected in the peripheral neuroretina at 10.5 and 12.5 dpc. Detected in the otic pit at 9.5 dpc and in the otic endolymphatic duct at 10.5, 11.5 and 12.5 dpc. From 10.5 to 14.5 dpc detected in the developing fore and hind limbs. At 10.5 and 11.5 dpc observed in the anterior and posterior margins and presumptive hand plate of the limb bud. At 9.5 and 10.5 dpc expressed in the limb. At 12.5 dpc is detected in the hand plate with strong expression at the margins of the limb plate. At 14.5 dpc detected in the hand plate and lateral edges of the digits. At 8.5 dpc expression was not detected in the developing somites. In contrast, from 9.5 to 12.5 dpc, expression is detected in a repeated pattern located lateral to the neural tube and in the interlimb bud region suggesting expression in somite derivatives. At 9.5 dpc detected in the forelimb dermamyotome. Also located along the lateral portion of the trunk and within a dorsal domain within the limb bud. At 10.5 dpc expressed in lateral and limb mesoderm. From 9.5 to 10.5 dpc detected in head mesenchyme and the branchial arches. At 9.5 and 10 dpc. expressed in the head mesoderm associated with the developing eye. At 10.5 dpc this pattern appears as a ring of expression surrounding the eye. At 11.5 dpc expression is still detectable in the branchial arches with strong expression at the cranial sinus. At 14.5 dpc mammary gland primordia. Detected in the nasal openings and vibrissae
+Detected in the later stages of pregnancy between day 60 and day 100 of gestation
+In fetal brain of the 24th gestational week
+Highly expressed in embryos in the developing central nervous system (CNS). Expression is seen as early as day 9 of development, where transcripts are abundant in the posterior neuropore. Expression in later embryos is detected throughout the CNS as well as in other structures
+Late embryonic and late pupal stages
+Low expression in embryos and L2 larvae, high expression in hermaphrodite adults
+Highly induced during normal senescence
+During visual system development, expressed in an anterior to posterior decreasing gradient stretching through the entire midbrain. This gradient has the reverse orientation to the one defined by the expression of ephrins. Isoform 4 and isoform 5 are expressed at the edges of the embryonic cranial neural fold. In myogenic progenitor cells, highly expressed, at least as early as 11.5 dpc, expression decreases until 4 weeks after birth (PubMed:27446912)
+Its expression occurs in the postmeiotic phase of male germ cell development. First detected in 30 days old mice and thereafter into adulthood. Barely detectable in 20 days old mice and absent before this period
+Expressed in embryo throughout the early nervous system. Strongly expressed in differentiating neurons in the brain, spinal cord and retina. Not detected in the lens at any developmental stage tested
+In 37 day post-ovulation (dpo) embryos, expression is found in the mid- and hindbrain, regions known to be involved in motor control of eye movement, and in the ventricular zone of the forebrain. In 56 dpo embryos, expressed in the ventricular layer of the forebrain, midbrain, cerebellar primordium, spinal cord and the developing neural retina. In later development, highly expressed in postmitotic cells within the developing subplate and cortical plate
+Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at G1 phase (at protein level)
+During seed development, confined to green cotyledons of mature embryos. In germinating seedlings, detected in cotyledons and the root hair zone of the primary root. In older seedlings, restricted to cotyledons
+Isoform 1 increases from day P4 to P64. Isoform 2 increases after day P8
+Expressed constitutively during plant development, with a strong increase during flower development
+Appears in gastrulae and remains at a similar level until the pluteus stage
+Expressed at the time when separation of neural and epidermal precursors cells occurs. Mesectodermal expression appears shortly before the onset of gastrulation. In imaginal disks, expression is seen primarily within presumptive proneural clusters of eye-antennal, wing and leg disks
+Total crystal protein is produced during sporulation, appears after 6 hours of growth, and represents about 4.8% of cellular dry weight in stationary phase. It probably accumulates next to spores within the exosporeum
+Present as a maternal transcript in the egg as well as during cleavage development before blastocyst formation. At 7.5 dpc, strongly expressed in all trophoblast cells (PubMed:16759287). Expression seen in the ectoplacental cone and extraembryonic mesodermal components of the amnion, allantois and visceral yolk sac. This high extraembryonic expression persists in the embryonic component of the placenta throughout development. In the embryo, expressed at 7.75 dpc in the lateral mesoderm along the entire length of the embryo as well as throughout the precardiogenic mesoderm. At 8.0 dpc, in the developing heart, expression becomes restricted to the rostral and caudal regions of the straight heart tube, which are fated to form the conotruncus and left ventricle, respectively. Symmetric expression is observed along the left-right axis in the caudal heart tube and lateral mesoderm. As cardiac looping occurs, the interrupted anterior-posterior patterning is maintained with expression in the future left, but not right ventricle. Expressed in the myocardium, but not in the endocardium, and specifically on the greater curvature of the looping heart which is opposed to the pericardium. After day 10.5 dpc, the high cardiac expression level declines abruptly. By 13.5 dpc, expression in the heart is restricted to the regions of valve formation. Besides the heart, expression becomes detectable in the gut at 9.0 dpc. At 10.0 dpc, expressed also in the lateral mesoderm and in the neural crest-derived branchial arches. At 10.5 dpc prominent expression in the gut, pharyngeal arches and in sympathetic ganglion primordia. At that stage, a low level of transient expression is seen in the distal posterior region of the limb bud. At 12 dpc expressed in the conceptus trophoblast giant cell layer in the placenta (PubMed:16759287). At 13.5 dpc expressed in neural crest derivatives, with abundant expression in the autonomic nervous system and adrenal medulla
+Expressed at 14 dpc
+Appears at centromeres during the pachytene stage, when homologous chromosomes are synapsed. Peaks during diplotene stage, persists with gradual reduction until metaphase I, and disappears in anaphase I. Does not reappear on chromatin in meiosis II
+Expressed in new born and adults
+Expressed in developing cortex at all stages examined but most strikingly at 12 gestational weeks. Expression is found in both progenitor (ventricular zone) and neuronal (intermediate zone and cortical plate) compartments. Also selectively expressed within the choroid plexus within the cerebral ventricles
+At 24 h post-fertilization (hpf), it is mainly expressed in the central nervous system and the tail bud. It is detected in the brain and motor neurons of the spinal cord at 48 hpf
+Expression in fusion-competent cells is about 6 times higher than fusion-incompetent cells. Remains high until 8 hours of sexual development, and then slightly decreases. In the asexual development, the transcript level increases temporarily during the pre-aggregation stage (4 hours), and then returns to the basal level
+Expressed at the end of the exponential growth phase
+Up-regulated in the testes from 11.5 dpc until 16.5 dpc, expression is maintained in the male Sertoli cells throughout embryonic development and into adulthood. Not expressed in the female gonad during embryonic development (PubMed:17616727, PubMed:18321981). Expressed in the granulosa cells, a few days after birth, expression is maintained in granulosa cells during folliculogenesis (PubMed:17616727, PubMed:18321981). Up-regulated during embryonic pancreatic acinar cell differentiation (PubMed:19097053)
+Not induced during senescence
+Present at late stages in developing flowers
+Expressed during fetal development, as well as in tumor cell lines containing amplified MYCN loci, where it is expressed at very high levels
+Expressed during embryogenesis (at protein level)
+In larva, detected in the optic lobe and weakly in the neuroblasts (at protein level) (PubMed:22357926). Expressed at the time when separation of neural and epidermal precursor cells occurs (PubMed:2540957). Mesectodermal expression appears shortly before the onset of gastrulation (PubMed:2540957). In imaginal disks, expression is seen primarily within presumptive proneural clusters of eye-antennal, wing and leg disks (PubMed:2540957)
+Expressed throughout the meristem during embryonic and vegetative development. Expressed in floral organogenic regions
+In mature embryos, restricted to provascular tissues. Also present in the seed coat outer tegument and silique epidermis. Levels decrease during seed imbibition and germination
+Expressed at low levels throughout the embryo and is enriched in the developing brain and spinal cord
+Expressed at 12 dpc throughout the ventricular zone and developing cortical plate and ganglionic eminences. At 16 dpc detected throughout the brain but most strongly in the cortical plate. At postnatal day 3 expressed widely with strong expression in cerebral cortex and hippocampus
+In an ex vivo erythroid culture system, highly expressed from early (preproerythroblasts) to mid (basophilic normoblasts) maturation. Markedly reduced in more mature erythroblasts (at protein level). The decrease in LYAR protein correlates with the rise of beta-globin (HBB) mRNA levels during erythroid cell differentiation
+Expressed in the Pn.aa neuroblasts and in each of their descendant cells, the Pn.aaa, Pn.aap, Pn.aaaa and Pn.aaap cells and the three differentiating neurons generated by each Pn.aa neuroblast; expression is transient, becoming undetectable shortly after the cells are generated in the larval L1 stage (at protein level) (PubMed:11923211). Expressed in the AVM and PVM touch neurons at the L1 larval stage until the early L2 stage (PubMed:9169852). Expressed in the VA and VB motor neurons and their immediate precursors in late L1 to early L2 stage (PubMed:9169852)
+Expression is first detected at postanatal day P7 and increases until P42 (at protein level)
+Expression is low in larval stages and increases before ecdysis; consistent with role in postecdysial cuticle changes
+Expression level is progressively up-regulated during neural differentiation from neural progenitor cells at 12.5 dpc to 18.5 dpc
+Expressed in the suprachiasmatic nucleus (SCN) during late fetal and early neonatal life
+Expressed maternally and zygotically. Expressed in all cells of early embryos. In late embryos and L1 larva, it is weakly expressed, mainly in Z2 and Z3 cells
+Expressed from 1 dpf in the brain and pronephric tubules. At 3 dpf, expression expanded to the eyes and neuromasts, where mechanosensory hair cells exist, along the lateral line
+High levels of maternal transcripts in blastoderm stage embryos are observed
+Expressed in endodermal cells surrounding endothelium in the yolk sac and in periventricular cells of the neuroepithelium in the brain
+Expressed in a structure probably corresponding to the thymic rudiment 12.5 dpc. No expression could be detected at earlier and later stages of embryonic development (10.5 dpc and 17.5 dpc)
+Expressed in prespore cells
+Detected in neonatal submandibular and parotid gland secretion but not in sublingual gland secretion (at protein level). In submandibular gland, expressed at high levels in the first postnatal week, with expression diminishing thereafter
+Highly expressed in developing organs
+Detected in embryo from 10.5 to 13.5 dpc. Strongly expressed from 9.5 to 11.5 dpc in the diencephalon, mesencephalon, metencephalon, myeloencephalon, and the developing eye
+Transcript levels rise steadily during syncytial stages to reach a peak in early cycle 14 and then decline rapidly during cellularization
+Expressed in the genital ridges of six-week-old male embryos. Becomes confined to the forming seminiferous tubules (probably Sertoli cells) at seven weeks. Not detected in female embryos
+Regulated in a cell-cycle dependent manner. Highest expression in G1 phase. Expression decreases during S phase, rises again during G2 and drops during mitosis (at protein level). In contrast to protein levels, transcript levels do not show any significant variation during different stages of the cell cycle (PubMed:22935713)
+Expression is initially detected at the tailbud stage, immediately after gastrulation, in the cephalic mesoderm. It is maintained in the mesoderm during early stages of development. Expression is initiated in the neural crest by the 5 somites stage, and is restricted to a rostral domain of cranial neural crest. Later during development it is still expressed in specific regions of the neural crest-derived facial mesenchyme. In 24 hpf stage embryos, expressed strongly in the periocular mesenchyme. By 48 hpf, expression is maintained in the periocular mesenchyme towards the anterior of the head, with weaker expression in the nasal region and the prospective palate. Also expressed in a discrete region at the distal tip of the mandible arch and in the pectoral fin bud primordia
+Expressed during embryonic, larval, and adult stages
+Expressed in seeds at early and mid-maturation stages
+Expressed in fetal liver, kidney and brain
+Expressed in the brain from 13.5 dpc
+Strongly expressed in the presomitic mesoderm, where its mRNA exhibits cyclic waves of expression whose temporal periodicity corresponds to the formation time of one somite (90 min)
+Down-regulated during breast cancer progression
+In leaves and hypocotyls, mostly observed in vascular tissues (PubMed:30407556). In root tips, restricted to the lateral root cap of primary and lateral root meristems (PubMed:30407556)
+Predominates during high metabolic activity in growing buds, root tips, leaf margins and germinating seeds
+Expressed 7 hours after introduction into phosphate poor media
+At neuromuscular junctions, 5-fold higher expression levels at P0 compared to adult
+Observed in spermatocyte meiosis I and II stages (PubMed:21711156). Expressed during spermiogenesis (PubMed:29298896)
+Expression begins at the end of second larval instar, present throughout third larval instar and is gone by the pupal stages
+Expressed in embryos (PubMed:31907206). Expressed in larvae (PubMed:24643112)
+In non inoculated roots, present at low levels in both epidermis and cortex. Levels increase two days after inoculation with Sinorhizobium meliloti, especially in root hair cells. During infection, mostly expressed in cortical cells where infection thread (IT) progresses and in underlying layers. Detected in the whole cortex of young nodules. In mature nodules, localized in the infection zone
+In corollas, accumulates progressively during flower development, from buds to anthesis, with a peak at flower opening, but fades out in senescing flowers
+Expressed during the exponential phase of growth
+Maternally and zygotically expressed. Expression decreases between late blastula and early gastrula
+Expressed during sexual reproduction; expression increases during meiosis II (at protein level)
+Expressed in prestalk pstA and pstO cells in the slug stage. Preferentially restricted to pstO cells during culmination
+Expressed in fetal kidney and to a lower extent in liver, lung and spleen
+Expressed in oocytes and in the early embryo and down-regulated afterwards (at protein level)
+Is expressed at a constant level throughout development
+Expressed at 7.5 dpc, in a limited way, in the posterior portion of the egg cylinder in the nascent mesoderm streaming off the primitive streak. At the distant end of the embryo cylinder, expression ended at the node. Later in the development, expression seems to be limited to developing skeletal muscle and central nervous system
+Confined to the root stele in the elongation and differentiation zones of both primary and lateral roots. Disappears at the sites of lateral root initiation. In the root tip, present at and above approximately 10 cells after the onset of elongation
+Expressed in the heart at 16 dpc (at protein level) (PubMed:20639889). On P7, detected mainly at the apical surface of hair cells (PubMed:16418530). In outer hair cells, it was observed in the kinocilium and in the basal body region at the periphery of the hair cell (PubMed:16418530)
+Expressed in late stage embryos and throughout life
+Expressed in early stages of flower development. Highest expression is observed when the panicle growth reaches 30 millimeters
+Expressed ubiquitously at low level after 7.5 dpc. At 8.5 dpc high levels of expression are detected throughout the neural tube, and in the dorsal aspects of the neural folds of the future midbrain region and the somites. At 9.0 dpc high levels of expression are detected in the ventral domain of the neural tube, developing eye, floor plate, notochord, and gut endothelium. At 10.5 dpc expression high levels of expression are detected in the dermomyotome of the somites, limb-bud mesenchyme, mantle layer of the dorsal neural tube, and developing trigeminal ganglion
+Evenly distributed throughout the neonatal brain
+Strongly expressed in brain, heart, liver at 14.5 and 16.5 dpc. Strongly expressed in brain at 20 dpc. Weakly expressed in heart and liver at 20 dpc (at protein level)
+Produced by the cephalic glandular system of the nurse honey bee
+Expressed both maternally and zygotically. Expression in maintained in the ZW and ZZ gonads
+Predominantly found in promastigotes
+The expression patterns in adult and day 15.5 embryos are similar
+Expressed poorly in 7-day-old brain. Expression increases at day 15 to reach a maximal level in 35-day-old brain
+Expressed during larval and adult stages with the highest expression during the L2 stage of larval development (PubMed:14730154). Expressed in head neurons at pre-dauer, dauer and post-dauer larval stages (PubMed:23132577). During the dauer stage, also expressed in tail neurons, amphid neurons, the ventral nerve cord and AVG interneurons (PubMed:23132577)
+Expressed both maternally and zygotically. Levels are highest in 0-2 hours embryos and at lower levels during later embryonic and larval stages. A modest increase in expression is seen during the pupal stage. Expressed throughout the 9 hours embryo. After 12 hours expression is concentrated in the central nervous system
+Expressed in germinating seeds and in very young seedlings. Expressed in developing siliques 3-13 days after pollination
+Low level on day 8, abundant on days 10 to 14, and decreases by day 16
+At 8 dpc, expressed in the developing hindbrain in regions that give rise to rhombomeric segmentations r3, r4 and r5
+Maternally expressed. Ubiquitously expressed until stage 16. Expressed in the pre-placodal ectoderm domain at stage 18. Expressed in the epibranchial placodes of the tailbud embryos. Expressed in the pronephros
+In young plants, expressed in the distal regions of cotyledons, throughout leaves and root apical meristem, lateral root meristems and young floral buds. Strongly detected in the vascular tissues of various organs (e.g. roots, leaves, hypocotyls, sepals, petals, anther filaments) as well as in the gynophore. In the gynoecium, mainly detected in apical and basal regions as well as in the developing ovules in these regions
+Released into the circulation after a meal
+Expressed relatively early during neuronal differentiation
+First expressed during embryogenesis in the AB lineage, as the lineage increases from 16 to 32 cells (PubMed:8162851, PubMed:9872954). Expression in the AB lineage diminishes around the 168 cell embryo stage and the expression pattern becomes symmetrical about the embryo's plane of bilateral symmetry (PubMed:8162851, PubMed:9872954). Also expressed in the lineage of the D founder cell initially in the 100 cell embryo (PubMed:8162851, PubMed:9872954). As embryonic elongation commences, expressed in Z1 and Z4 cells; this expression increases during the rest of embryogenesis and disappears shortly after hatching (PubMed:8162851). Expressed in the MS lineage, specifically in MSaaa and MSaap at the 51-cell stage (PubMed:9872954)
+Expressed during spermatogenesis, in primary spermatocytes and imaginal disk morphogenesis
+Expressed from 14 dpc at a time when developing axons reach the olfactory bulb
+Expressed in most cells of the early embryo. From the two-cell stage until late embryogenesis, expression is restricted to pharyngeal cells. Detected in two intestinal cells during the larval stage
+At 10.5 dpc, expression is relatively ubiquitous with the strongest signals detected in the limb buds, eyes and branchial arches and a weaker expression in the telencephalon and spinal cord
+Present in oocytes as well as in early embryos
+After seed stratification, first observed in the micropylar end, later present in the endosperm region and in the testa, and finally accumulates in the endosperm and emerging radicle. In seedlings, first detected in the root and cotyledon tips, expression level reaches a maximal at the cotyledonary leaf stage and is later confined in the shoot apical meristem. In roots, expressed at the primary root tip, at the basal side of root curvature, and at the lateral root tip (PubMed:24285794). Also observed in very young primordia, floral buds, and stamens (PubMed:24285794, PubMed:24260266). In stamens, mostly present in the anther containing immature pollen and, at low levels, in the filament. In siliques, highly expressed in the abscission zone and, to a lower extent, in developing seeds (PubMed:24285794)
+Detected from 9.5 dpc in the cardiac valve precursor cells from the atrioventricular cushions and outflow. At 10 dpc expressed in the cardiac jelly covering the trabeculating cardiomyocytes of the left ventricle, the outer curvature of the right ventricle and the outflow tract. Expression in the ventricles decreased gradually as development progressed, and disappeared by mid-embryogenesis (at protein level)
+Expressed in cells immediately adjacent to ventral mesodermal lineage (M lineage) cells, but not next to dorsal M lineage cells, beginning at the 4-M stage (PubMed:18036582). Expressed in all six vulval precursor cells (VPCs) in the early larval L3 stage, subsequently more highly expressed in P6.p while the expression in the other VPCs diminishes (PubMed:14960273, PubMed:21596897). Expressed in the anchor cell (AC) and distal tip cells (DTCs) of the somatic gonad at larval stage L3 (PubMed:21596897). Expressed in the inter labial IL2 neurons at the onset of and throughout the developmentally arrested larval state known as dauer (PubMed:18599512)
+In the developing mammary gland, expression is barely detected in the immature gland at 3 weeks after birth but is evident at the onset of puberty at 3.5 weeks. Expression is high at 4 weeks, declines at 4.5 weeks and is undetectable at 5 weeks. No expression is detected in the mature mammary gland during estrus, pregnancy, lactation or involution. In skin, expression starts shortly after birth and reaches a first maximum at 9 days. A second peak of expression is observed at 3.5 weeks, then levels decline and remain low in the adult. During the hair growth cycle, detected in mid- and late-anagen stages but not in catagen, telogen or early anagen phases
+In inflorescences, first observed in flower abscission zones and stems (PubMed:31829135). In seedlings, present at the leaf edges and petioles (PubMed:31829135)
+Expression starts at 8.5 dpc, and decreases to undetectable levels at 10.5 dpc and 11.5 dpc. Expression is strongly up-regulated at 12.5 dpc, decreases at 16.5 dpc and reappears at 18.5 dpc. At 12.5 dpc, ubiquitously expressed, with high levels in brain, spinal cord, tongue, lung and genital tubercle
+Expressed maternally in oocytes, unfertilized eggs and embryos up to the mid-blastula transition (MBT)
+Expressed only after 10 hours of development and its mRNA accumulates to peak at 18 hours when cells are initiating fruiting body formation. Highly expressed during phagocytosis of non-pathogenic bacteria
+Expressed in the developing lens
+Expressed at 13.5 dpc strongly in the upper lip, primary palate and medial edge epithelia of the secondary palate. At 14.5 dpc expression could be seen in the medial edge epithelial seam
+Expressed in the embryo at the heart and torpedo stages
+First expressed in between seam cells at the lima-bean stage of embryogenesis (PubMed:26586219). Expressed in the embryonic epidermis and in puncta in the epidermal syncytium and also in between the epidermal body syncytium and the seam cells of larvae (PubMed:26371552)
+In the eye, the expression was observed at stage 23 in the ocular surface epithelium ventral to the corneal epithelium. Strongly expressed in the entire ocular surface at stage 26 including the corneal epithelium. Remained strongly expressed at stage 30
+Expressed predominantly during early embryogenesis. Detected at high levels in 7, 11 and 14-day-old embryos but not in 18-day-old embryos. Very low levels detected in adults
+Developmentally regulated and reaches a maximum at or just after nuclear division (at 30 - 36h) when the daughter parasites produced by asexual reproduction are segregating to become individual merozoites. The levels drop dramatically at 36 - 42h and remain low through the rest of the life cycle. Detected in the schizont stage. Increased expression may correlate with postmitotic nuclear vesicle fusion
+Expressed in all stages but highest during L1, L2 and L3 stages (at protein level)
+Expression begins at 10.5 dpc and increases as development progresses to 17.5 dpc. Expression rises in parallel with the differentiation of vascular smooth muscle cells (VSMCs) of the aorta
+Expressed in muscle, kidney, brain, stomach and intestine at 6 dpc. Levels increase in the brain from 6 dpc to 18 dpc, and decrease in muscle and intestine. Levels in the kidney remain constant. From 10 dpc, expression also found in heart, lung, skin and liver. Levels in the liver increase dramatically at 18 dpc. At 18 dpc, highest expression found in kidney and brain. In the embryonic central nervous system, the spinal cord expressed the highest levels. Lower levels found in the medulla oblongata, pons, cerebellum and midbrain, and very low levels in the forebrain
+Expressed during fruiting initiation in primordia and immature fruiting bodies
+Confined to the egg cell before fertilization, but disappears upon gamete fusion. Also present in zygotes and early embryos
+Detected throughout development from L1 to L4 and during adulthood (PubMed:15282167). Expressed in P3.p to P8.p vulval precursor cells in the late L1 and early L2 larval stage (PubMed:9716532). Not expressed in vulval precursor cells P1.p, P2.p, P9.p, P10.p or P11.p in the mid-L3 larval stage (PubMed:9716532). Expressed in other postembryonic cells including seam cells (PubMed:9716532)
+Shows relatively low expression levels in proliferating myoblasts. Expression peaks at around day 1 of differentiation into myotubes and decreases again by day 10, when assayed in C2C12 cell line (at protein level)
+Undetectable in the fetal testis, shows the highest expression level in post-puberty testis, with the expression levels decreasing afterwards with aging
+Expressed during early and late male gametogenesis, and in cells of the embryo sac at the time of fertilization. After fertilization, expressed in the embryo, suspensor, and endosperm until the cotyledon stage embryo
+First detected in the neural groove at 8.0 dpc. At 8.5 dpc, detected in lateral plate mesoderm, the dorsal region of the somites, the floor plate of the neural tube and in head mesenchyme. At 9.5 dpc, detected in dorsal paraxial mesoderm, lateral plate mesoderm and in nephrogenic cord tissues. At 10.5 dpc, detected in lung buds, developing mesonephros, mesodermal tissue surrounding dorsal root ganglia and adjacent to the forlimb buds
+In the embryo, expressed during all stages of development
+Accumulates during aggregation and remains constant throughout culmination
+Expressed during the asexual blood stage including in rings, trophozoites and schizonts (at protein level)
+Highly expressed during germination and early development, with levels peaking at 25 days
+Expressed both maternally and zygotically. Predominantly expressed in the early stages of oogenesis (stages I to III), with expression levels declining from stage IV onwards. Zygotic expression begins at the early tailbud stage
+Transiently expressed in the intestine during larval development (PubMed:27104746). Expressed in the intestine in L1 stage larvae, not expressed in L2 to L3 stage larvae, but is then again expressed in the gonad of L4 stage larvae (PubMed:27104746). Expressed in seam cells during larval development (PubMed:27923661). Broadly expressed throughout development in multiple male somatic tissues, including pharynx, ventral nerve cord, body muscles, diagonal muscles, and hypodermis (PubMed:27923661)
+Detected just before birth in Schwann cells and after birth in oligodendrocytes of brainstem and spinal cord
+Expressed throughout the intraerythrocytic cycle, with highest levels during the ring, mature trophozoite and mature schizont stages and lower levels during the young trophozoite and young schizont stages
+Transiently elevated expression during gestation, and decrease at term
+During embryo development, expressed from torpedo stage (6 days after pollination) to mature embryo
+Its expression is regulated differentially in retinal cell types during development
+Expressed only in the sporophyte, a shell-boring, filamentous phase
+Expression levels are slightly decreased in subcutaneous adipose tissue following weight loss. Expression levels may be not affected by preadipocyte differentiation
+In embryos, it is expressed from stage 11 in the germ cell soon after their migration through the midgut epithelium
+Expression begins in embryos at stage 13 in two cells of each of the abdominal segments 1 to 7 (at protein level) (PubMed:12205712). Expressed at the third larval instars in the glia (at protein level) (PubMed:12205712, PubMed:17678856). Transiently expressed in the integument of late embryos at stage 14-15 (at protein level) (PubMed:19715698). Expressed in embryonic trachea from stage 11 until stage 15 (at protein level) (PubMed:19715698). In the second and third larval instars, expressed at the periphery and in cells within the brain hemispheres arranged in a crescent-shaped structure (at protein level) (PubMed:9852943, PubMed:12205712, PubMed:25229196). In the ventral ganglion, expressed in cells arranged in two rows: one on each side of the ventral nerve cord (at protein level) (PubMed:9852943, PubMed:12205712). Also expressed in the anterior and posterior spiracles (at protein level) (PubMed:12205712). During pupal stages, no expression between 24 and 60 hours after puparium formation (at protein level) (PubMed:11934851, PubMed:12205712). Expression resumes 60 hours after puparium formation in the lamina neuropil, in single cells at the distal border of the medulla and in some cells of the deeper lobula and lobula plate neuropils (at protein level) (PubMed:12205712). In pharate adults, just before eclosion, expressed in epidermal cells; expression levels are similar in all cells that secrete the abdominal tergites (at protein level) (PubMed:11934851). In pharate adults, expressed in the esophagus epidermis and in the ommatidia lens cuticle (at protein level) (PubMed:19715698)
+Strongly but transiently up-regulated in oligodendrocytes at the onset of myelinogenesis. Once these last have engaged their target exons, expression declines precipitously
+This protein is expressed in growing cells and deactivated upon the initiation of development
+Expression is seen at 12.5 dpc and 14.5 dpc embryonic stages
+Higher expression in pre-natal (1-5 months gestation) than in postnatal (4-6 months) calf lens
+Expressed in all larval stages, increasing in level from L1 to L4 and then diminishing in younger and older adults (PubMed:7671813). Expressed in hermaphrodite lateral hypodermal seam cells during the larval L3- to L4-molt stage and into adulthood (at protein level) (PubMed:8756296). Expressed in the hypodermal cells of the head (hyp1-hyp6), tail (hyp8-hyp12), and the large hypodermal syncytium covering most of the animal (hyp7) (at protein level) (PubMed:8756296, PubMed:27401555). Also expressed in some non-hypodermal cells during stages L2 to L4 (at protein level) (PubMed:8756296, PubMed:9334281). Expressed in the anchor cell beginning at the L2 molt or early L3 stage (PubMed:9334281). Male-specific expression in the linker cell (LC), positioned at the tip of the growing end of the gonad at stage L3 (at protein level). Male-specific expression in ventral cord neurons from late L3 stage (at protein level) (PubMed:9986728)
+Expressed in all larval stages, increasing in level from L2 to L4 and then diminishing in younger and older adults (PubMed:7671813). Expressed at low level in lateral seam cells in larval L3 stage and up-regulated during L4, including in the major hypodermal syncytium hyp7 (PubMed:32223899)
+Found in dormant conidiospores
+Expressed in undifferentiated embryonic stem cells, as well as early embryo from two-cell stage to blastocyst
+Expressed both maternally and zygotically. Abundant in oocytes, with expression maintained through the midblastula stage, declining in gastrula and neurula stages, and disappearing by the tailbud stage (at protein level)
+Expressed at the early stage of germination and during the conversion of glyoxysomes to peroxisomes. Accumulates at high levels in seedlings and at lower levels as plants mature
+Expression in the embryo overlaps that of LIM domain-containing proteins (PubMed:9192866). Expressed widely in the embryo with highest expression in several regions of the brain, and the central nervous system ganglia (PubMed:9192866)
+Protein found in 2-day-old hatched larvae (stage 35)
+Highly expressed in the developing midbrain and the eyes at 24 hpf. The expression becomes restricted afterwards to the posterior part of the midbrain and the midbrain-hindbrain boundary
+Accumulates progressively during fruit development, but fades out in ripe fruit
+Not detectable at 20 days postpartum (dpp), barely detectable at 22 days postpartum and is strongly detected thereafter (at protein level). Expression is restricted to spermatid stages
+Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes
+Expressed both maternally and zygotically. Expressed from stage 3 egg chambers onward, becoming restricted to the cortex of the oocytes at stage 10. Evenly distributed in preblastoderm embryos
+Expression is biphasic, peaking late in embryogenesis (16-24 hours embryos) and during the larval to pupal transition, when the musculature is differentiating. Found in developing muscles of the visceral and somatic mesoderm subsequent to the formation of the muscle precursor cells. Decreased levels are still detectable in adults
+Highly expressed during vegetative stage. Expression decreases during development and is very low in fruiting bodies
+Expressed in the course of oligodendrocytes maturation
+Expressed throughout development (at protein level) (PubMed:22269071). Highly expressed in embryos and L1 stage larvae (at protein level) (PubMed:22269071)
+Synthesis starts during germination and outgrowth, and is highest at the end of exponential growth. Present in dormant spores
+Expressed in the conidium during the process of appressorium formation
+Expression peaks in the early exponential growth phase and decreases towards the late exponential and stationary phases
+Expressed during embryogenesis (PubMed:23064028). Expressed in adults (PubMed:11733138)
+At the mRNA level, first detected in early pachytene spermatocytes. At the protein level, first detected in step 2 round spermatids. Expression continuously increases thereafter and peaks in spermatids at steps 7-9 (at protein level). Levels start to decrease after step 9 and in step 9-11 elongating spermatids (at protein level)
+Expression starts at 10.5 dpc in hepatocytes. Expressed in the acinar cells of the pancreas and cervical brown adipose tissue at 15.5 dpc. Expressed in white adipose tissue at 19.5 dpc. Up-regulated during preadipocyte differentiation into adipocytes (at protein level)
+Expressed during gastrulation in the three primitive germ layers and in the pharyngeal arches. In later stages, expressed in the developing nervous system, midbrain/ hindbrain boundary, cerebellum anlage, certain rhombomeres, regions of the spinal cord, and in the developing dorsal thalamus and corpus striatum
+Expressed maternally and zygotically. Expression is ubiquitous throughout embryonic development
+During embryogenesis, expressed in the embryo from octant to torpedo stage
+Highly expressed in the first instar larvae and then gradually decreases during larval development. Expression increases again in the wandering third larval stage. The lowest amount of expression is observed in the early and mid-pupal stages. After this, expression increases in the late pupal stage in both male and female adults
+Expressed in promastigotes and to a lower extent in axenic amastigotes (at protein level) (PubMed:14636673, PubMed:16384531). Low expression levels in lesion-derived amastigotes (at protein level) (PubMed:14636673, PubMed:16384531)
+Expression gradually increases from late embryonic (E18) stage until adulthood
+Highest expression is in embryos, low level expression is seen through rest of development
+Expressed in the procyclic form and the bloodstream form at low levels
+Expressed at the promastigote life cycle stage during the logarithmic growth and the stationary phase (at protein level). Expressed at lower levels at the amastigote life cycle stage (at protein level)
+Isoform 1 and isoform 2: Transcription starts at the beginning of seed maturation 9 days after pollination and reaches its highest level during the last phases of seed development (PubMed:26620523, PubMed:17065317, PubMed:22829147). Isoform 1: Upon imbibition the transcripts rapidly disappear in both dormant and after-ripened seeds, but the level of protein is hardly affected (PubMed:17065317, PubMed:22829147). Isoform 2: Transcription starts at the beginning of seed maturation 9 days after pollination and reaches its highest level during the last phases of seed development (PubMed:26620523)
+First detectable in the presumptive mesoderm at late cellular blastoderm stage
+Expressed during the asexual blood stage; expressed at the ring stage and, to a lesser extent, in trophozoites and schizonts
+Expressed in the notochord, Kupffer's vesicle, the most anterior region of diencephalon, otic vesicles, and the anterior and posterior lateral line primordia by 24 hours post-fertilization (hpf). From 48 to 72 hpf, expression is confined to the anterior and posterior neuromasts, otic vesicles, pharyngeal arches, pectoral fin buds, and cranial cartilages such as Meckel's cartilages, ceratohyals and trabeculae
+Expression begins at day 3-4 in the yolk sac and at day 5-6 in the embryo proper
+At 12.5 dpc, expression is restricted to neural tube, forebrain and midbrain
+Expressed in all stages, with abundance in embryo and only very weakly in larvae
+Constitutively expressed (PubMed:15037734). Not regulated during nodule development (PubMed:15037734)
+Expressed in the larval body and salivary glands
+Expressed during the early stages of tuber formation and persists throughout tuber development
+In young seedlings, mostly expressed in the newly emerging leaves and in the vasculature of roots and cotyledons (PubMed:25202318). Later fades out of the vasculature but remains at high levels in emerging leaves (PubMed:25202318). Present at the base of maturing leaves but excluded from the vasculature (PubMed:25202318). In short days conditions, accumulates in newly emerging leaves, but as these leaves mature, gradually lost in the lamina until being confined to the margin (PubMed:25202318). Disapears in mature leaves (PubMed:25202318)
+The expression is high during the lag and early logarithmic phases of growth, and low at or near stationary phase
+Expressed in certain chemosensory neurons (ASI amphid neurons) throughout development and is also expressed transiently in developing motor neurons when these cells undergo axonal outgrowth (PubMed:9502737). Expressed in the VA and VB motor neurons during larval L1 and L2 stages, but not in the precursor cell that generates them (PubMed:18817768)
+The short transcript is expressed moderately during early embryonic stages (0-18 hours) but then declines in late stage embryos (15-21 hours), becoming replaced by the long transcript which persists into the adult body
+During anther development, first confined to meiocytes, tapetal and middle layer cells. At the microspore stage, mainly expressed in the tapetum and microspores. Later observed in developing pollen grains
+Down-regulated in preimplantation embryos, with decreased levels observed at the 4-cell stages. Still detectable in blastocysts (at protein level) (PubMed:15317747). Expression in oocytes decline with age. It is much higher at 10 weeks of age rather than at 40 (at protein level) (PubMed:26411641). In ileum epithelial cells, up-regulated in the first 12 hours following rotavirus infection. Levels drastically decrease 36 hours post infection (at protein level) (PubMed:28636595)
+Expressed in the periventricular layer surrounding the tectal ventricle (9 dpc). Forms a spatial gradient with increasing concentration from the anterior to posterior pole of the embryonic optic tectum
+Expressed both maternally and zygotically throughout development with lowest expression levels in L2 and L3 larvae, and highest expression levels during pupal development (PubMed:12482983, PubMed:12697829). Highly expressed in all developmental stages, though its abundance decreases in L2 larvae then returns to high levels in pupae (PubMed:19921261)
+Highly expressed in embryonic cerebral cortex between day 18 and up to birth. Expression levels decrease after birth (at protein level)
+First expressed at 8.5 dpc in a few cells of the ectoplacental cone and, at 9.5 dpc, in a greater number of cells in the labyrinthine region of the forming placenta. In the embryo per se, expression starts at 9.5 dpc. At 10.5 dpc, detected in the facial area in the tissue overlaying the mandibular cleft and in the optic cup. In the central nervous system, expressed in the neuroepithelium at the roof of the mesencephalon and in the spinal cord. At 11.5 dpc, in the central nervous system, expressed in the neuroepithelium at the border between mes- and metencephalon and that lining the fourth ventricle and the retina, as well as in the spinal cord. Outside the nervous system, at 11.5 dpc, expressed in the mesenchyme over-laying the mandibular cleft, in the distal limb buds, especially the hind limb buds, as well as in the perichordal mesenchyme in the rostral region of the embryo. At 12.5 dpc, in the central nervous system, highly expressed in the rhombencephalic isthmus. In the facial area, expressed in the mesenchyme surrounding the olfactory epithelium and the forming vibrissae. Expression in the hind and front limb buds increases and spreads to more proximal directions, but is restricted to the area were the digits develop. At 13.5 dpc, the expression in the brain becomes restricted to the border between mes- and diencephalon. Also detected in the pituitary. Strongly expressed in the mesenchyme adjacent to the mandibular cleft, as well as in the most lateral aspects of the tongue and the teeth anlagen. Weak expression in the body wall and mesenchyme surrounding internal organs. At 14.5 dpc, becomes hardly detectable in the nervous system. In the body, expressed in the perichondrium, but levels decrease with ongoing age (PubMed:9920770). In the limbs, at 14.5 dpc, expressed in the mesenchyme, but not in the overlying ectoderm of the limb bud. In developing lungs, at 14.5 dpc, expressed at low levels in both the epithelium and mesenchyme lineages (PubMed:29769720)
+Up-regulated during the transition from CD4-/CD8- to CD4+/CD8+ thymocytes
+Expressed at a moderate level in late pregnancy, at a low level through lactation, induced early in milk stasis, and expressed at high levels in most mammary epithelial cells during mid to late involution and inflammation/mastitis
+Expressed in fetal lung and thymus
+Expressed both maternally and zygotically throughout development with slightly lower levels during pupation
+Expressed in the developing central nervous system from 10.5 dpc to 16.5 dpc. Expressed in presumptive myogenic cells from 9.5 dpc until 16.5 dpc with highest levels at 10.5-11.5 dpc
+Constitutively expressed during the cell cycle and flagella regeneration
+In testis, not detected before 3 weeks after birth
+In embryos, expressed in trachea and hindgut (at protein level)
+Expressed in all life stages with high expression in L1-L4 larvae stages
+Expressed in developing embryos until heart stage
+Detected in tachyzoites (at protein level) (PubMed:11861763, PubMed:28898199). Expressed in rapidly dividing tachyzoites (PubMed:11861763)
+Embryogenesis
+Expressed from day 3 of gastrulation, expression peaks on day 6 before decreasing on days 8 and 10 (PubMed:30773261). Expressed throughout gestation in the embryo proper, trophoblastic stems cells in the ectoplacental cone and decidual cells (PubMed:28295343). Expressed in trophoblast giant cells and maternal decidua in the placenta and in the endometrium at 9.5 dpc (PubMed:28295343). Expressed in the developing heart, head and otic vesicle at 9.5 dpc (PubMed:30773261). Abundantly expressed in giant cells and weakly expressed in labyrinthine trophoblasts and spongiotrophoblasts in the junctional zone, also expressed within the cytoplasm and perinuclear region of pre-glycogen cells at 12 dpc (PubMed:28295343). Expression in all trophoblast populations reduces as placentas near term (PubMed:28295343)
+Expressed in the intestine throughout larval stages and adulthood
+Detected in embryos (at protein level)
+Accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase
+In 2-cell and 4-cell stage interphase blastomeres expression is restricted to a sub-nuclear band that encircles one or more large vacuoles within the nucleus. These vacuoles may give rise to the mature nucleolus. Later in embryogenesis high levels are detected in developing liver. Is also widely and highly expressed throughout the developing brain and spinal cord at embryonic day 13
+Highly expressed in granulosa cells of ovulatory follicles. Detected at low levels in granulosa cells during the rest of the estrous cycle
+During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells
+Expressed after the segmentation stage
+In the liver, expression is higher in the adult stage than in the fetal stage
+Expressed both maternally and zygotically. Expressed in all cells of early embryos. In late embryos and L1 larva, it is weakly expressed, while it is expressed at intermediate levels in the germline of L4 larvae
+Isoform VEGF-166 is expressed early at day 1 and increases during gastrulation. Expression of isoform VEGF-190 is detectable only from day 2
+First detected in sporogenous cells at late anther stage 4. Maximum levels observed in male meiocytes at anther stage 5, prior to meiosis. Fades out at anther stage 6, during meiosis to disappear later. Also present at low levels in the placenta of very young pistils
+Highly expressed from 2-8 hours after egg laying (AEL). Expressed in broad anterior and posterior domains in stage 6 embryos (late cellular blastoderm). Almost ubiquitous in stage 8/9 embryos with higher levels anterior to the hh/en stripe. This anterior bias persists in stage 10 embryos. Absent from hh/en-producing cells. Expressed in the wing margins of third instar larvae
+Present from pre-meiotic DNA replication and throughout meiosis I
+Expressed at least from 9.5 dpc. Expression levels increase up to 15.5 dpc and remain high at least until birth
+Detected in germline and follicle cells. Expressed in follicle cells throughout oogenesis. In germline cells, expression levels increase as cells develop and move to the posterior region of the germarium, then at stage 5 of egg chamber development levels decrease until it is no longer detected (at protein level)
+Expressed in adults but not embryos
+Isoform 1 is activated specifically during the S and G2/M phases of the cell cycle
+High expression levels in fetal and infant brains; much lower in adult brains
+Expressed during hematopoiesis
+Expressed both maternally with high levels during oogenesis, and zygotically
+In the developing kidney expressed at 13.5 dpc in the periphery of the metanophros and surrounding the uretic and nephrogenic tubules. At 14.5 dpc, expression decreases in the outer cortical cells and becomes visible in the tubular parts of the nephron. From 15.5 dpc, highly expressed in the future loops of Henle. In the developing CNS, expression located to the forebrain and hindbrain. At 8.0 dpc, expressed in the future forebrain and in the ventral portion of the presumptive hindbrain. At 8.5 dpc, expression is maintained in these tissues with a strong signal in rhombomere 4. Until 11.5 dpc, expression continues in the hindbrain with additional expression at 9.5 dpc and 10.5 dpc, in the nasal and epibranchial placodes. In the forbrain, initial expression is found in the proencephalon of the forebrain, and then strong expression in the telencephalic vesicle up to 15.5 dpc. Expression is then found in specific cell populations throughout the brain. In the developing eye, expression, by 10.5 dpc, is confined to ectodermal cells overlying the dorsal part of the optic cup. In later stages, expression limited to the lens fiber cells and the future pigmented retina. By 15.5 dpc, expression is confined to the anterior part of the lens. During limb development, barely expressed until later stages, when it is found in the distal part of the separating phalanges. In other developing structures, expressed in nasal placodes at 9.5 dpc, in medial nasal processes at 10.5 dpc and then in the anterior portion of the invaginating olfactory epithelium. At 15.5 dpc, expressed on the basal side of the nasal epithelium. Also expressed in developing teeth, with the highest levels at 15.5 dpc and 16.5 dpc in the mesenchyme and the dental epithelium of the developing molars. As well, expressed in the ventral body wall, in the mesenchyme derived adrenal cortex, the cochlear epithelium and the branching epithelium of the salivary gland. In the developing heart, weakly expressed from 8.5 dpc in the tubular heart endocardium and myocardium. From 8.5 dpc to 12.5 dpc expressed in cardiomyocytes. At 9.5 dpc, expression found in the common ventricular and atrial chamber of the developing heart, in the aortic sac and in the sinus venosus. High expression found from 11.5 dpc-12.5 dpc, in the trabeculated wall of the ventricular chamber together with the wall of the atrial chamber. Expression also found in the muscular part of the interventricular septum. From 9.5 dpc-11.5 dpc expression in the visceral yolk sac confined to the inner lining endothelial cell layer. Expression in the developing heart decreases after 14.5 dpc
+In seedlings, mostly localized in shoot meristems, root tips and hypocotyl. In adult plant, strongest levels observed in the vasculature, pollen, pollen tubes, and trichomes. Also found in senescencing leaves
+Expressed during the parasite blood stage, including in rings, trophozoites, schizonts and free merozoites (at protein level)
+Specifically and highly expressed during seed maturation at 12 days after flowering (at the protein level)
+Probably maternally supplied, the zygotic expression becomes significative at 6 hpf and is stable from 7.5 hpf to 24 hpf
+During flower development, first expressed in anthers and later in seeds
+Expressed both maternally and zygotically. Expressed throughout development
+Expressed continuously from preinfection to the stage of the functional nodule
+Highly expressed in the embryo; barely detectable in the adult stage
+Expressed under aerobic and anaerobic conditions
+Expressed maternally and maintains its level until stage 10 of oogenesis (PubMed:19371384). Expression decreases significantly around stage 12, during oocyte maturation (at protein level) (PubMed:19371384, PubMed:22732570)
+Expressed during the asexual blood stage, including in rings, trophozoites and schizonts (at protein level)
+Zygotic expression begins after mid-blastula and expression levels rise gradually up to stage 41
+Transcripts accumulate in mature pollen before and during germination, but translation starts only when pollen germination initiates, and continues in pollen tubes
+Highly expressed at L1 larval stage and to a lesser extent in adults
+Expressed in the somites of the embryo in a wave along the anterior-posterior axis
+High levels in mammary glands of virgin mice and in mammary glands of pregnant mice associated with extensive proliferation of ductal cells and lobulo-alveolar development. Expression declines at the beginning of lactation when the glands fully differentiate. No expression after day 2 of lactation until day 21. Expression may be controlled by ID1
+Highest levels in immature megakaryocytic cells. Disappears after final differentiation to platelets
+During larval development, expression in the hemolymph increases at day 3 before the fourth ecdysis and then decreases again. Levels increase again at day 8 and then decrease again. Not detectable in pupae, or present at very low levels
+Expression is up-regulated during metamorphosis and embryogenesis. Barely expressed in third instar. Expression increases in fourth and fifth instar and is sharply increased in pupa, moth and oosperm
+Highly expressed in the female germline, more precisely in the nurse cells of maturing egg chambers. Also detected in the somatic follicle cells. Highly expressed during oogenesis and early blastoderm embryos. After the beginning of zygotic transcription, present in the elongating germband and later in the mesodermal region and the developing hindgut and posterior midgut. In late embryos, shortly before hatching, becomes restricted to the brain hemispheres, the central nervous system, the embryonic gonads and the gut. In third instar larval tissues, expressed in the larval brain and in all imaginal disks
+Expressed in the stomatal precursor cells and in immature stomata (PubMed:19513241). Decreases as leaves matured and no expression in fully expanded leaves (PubMed:18979118)
+First detected at 15 dpc to 16 dpc, at stage 20 dpc it is detected in presumptive cortex, medial limbic areas of the thalamus and hypothalamus. In the adult, it is found in hypothalamus, perirhinal cortex, amygdala and medial thalamic region
+Expressed at stage III of sporulation in the forespore compartment of the developing sporangium
+Isoform B: Ubiquitously expressed in embryos, larvae and adult (PubMed:10603085). Isoform C: Temporally restricted to the earliest hours of embryogenesis before cellularization (PubMed:10603085). As germ band extension commences, expression decreases along the entire ventral surface of the embryo and is restricted to the cephalic furrow (CF) and anterior and posterior dorsal transverse folds (DTFs) (PubMed:10603085). By state 7, restricted expression in the CF and DTFs on the dorsal and lateral surfaces of the embryo (PubMed:10603085)
+Detected at postnatal day 14 in developing testis (at protein level). Detected from postnatal day 18 onwards, with increasing levels through to postnatal day 36
+In 16.5 dpc embryos, expressed in forebrain, dorsal root ganglia, trigeminal ganglia, kidney, adrenal gland and lung
+Expression appears at the late embryo stage and continues to increase in abundance throughout the larval stage. No expression in pupae but is expressed in the adult
+Expressed in the epidermis throughout development (PubMed:21575913). Also expressed in the seam cells, which are specialized epithelial cells that secrete the cuticle, as well as in the intestine, the phasmid socket cells, and the excretory duct cell, as well as cells in the vulva and the dorsal rectal cells (PubMed:21575913)
+Expressed both maternally and zygotically. Appears in mitotic cycle 11 when the furrows made by the imprint of the embryonic nuclei become apparent
+Strongly expressed in 2-cell embryos. No expression detected in other embryonic stages or in adult testis
+Present throughout development, with highest level in early embryo (at protein level)
+Expressed in specific structures of the developing head, namely the brain, inner and middle ear, olfactory epithelium, vomeronasal organ, nasopharynx, oropharynx, papillae of the tongue and oral cavity, pituitary gland and epiglottis
+Expressed in the spinal cord of stage 22 embryos. Expressed during neurogenesis in the mantle zone of the spinal cord in domains corresponding to interneurons
+Transiently expressed during perinatal skeletal muscle development. It is first detected late in fetal life, is maximally expressed at the end of the 1st postnatal week, and is not found in the adult. Although their expression temporally overlaps
+Expressed during postnatal days P3 to P60, with increased expression after postnatal day 3
+In liver, the first peak of expression was found in 5-day-old neonates. Expression increases from day 7 and reaches a plateau at day 10. 3-6.5 moth-old adults express about a third the amount of neonates level. In kidney, expression increases from day 21 and reaches a maximal level at day 35, remains high until 3 months of age
+The peak expression is seen between 2 and 12 hours of embryogenesis. Expression continues through the larval instars and during pupation although at lower levels compared with embryogenesis
+Expressed exclusively in seeds from late embryogenesis until 1 day after imbibition
+Total crystal protein is produced during sporulation, it appears after 6 hours of growth, and represents about 4.8% of cellular dry weight in stationary phase. It probably accumulates next to spores within the exosporeum
+Late embryonic, late pupal and second instar larvae stages
+In flowers, present in the tapetum
+Expressed during later stages of embryogenesis
+First apparent at the comma stage of embryonic development, at the apical domain of intestinal cells. In subsequent embryonic stages, becomes visible in the hypodermis and pharynx. In larval and adult stages, detected in many epithelial tissues, including the pharynx, intestine, excretory canal and hypodermis
+Expressed in tadpoles from premetamorphic stage X, increasing until the end of prometamorphic stage (stage XX). Expression then declines during metamorphic climax stages (stages XXI-XXV), becoming undetectable at stage XXV and in adults
+Starts to accumulate in seeds between 8 and 12 days after flowering. Levels increase markedly between 15 and 18 days after flowering, reaching a peak between 26 and 33 days after flowering. Levels then decline rapidly at none is detected at 40 days after flowering. Not detected in germinated seeds
+During male germ cell development, expression of isoform 1 begins at day 21, increases after day 30 and continues to increase in the adult. Expressed in elongating spermatids from steps 9-12 (at protein level). Expression in the lung increases at 16 dpc
+Expressed in the embryo (at protein level) (PubMed:18794349). Expressed in most embryonic cells starting at gastrulation and also in head and tail cells during the larval and adult stages (PubMed:18794349)
+Expression present throughout embryogenesis. Higher expression between 9.5 dpc and 13 dpc
+Ubiquitously expressed 7-11 dpc. Present in nucleated embryonic blood cells from 9 dpc. Restricted to gastrointestinal tract, testis and lung from days 15-19 dpc
+Increases rapidly between 1 and 3 days after seed germination (PubMed:16813579). In leaves, detected mainly at the budding time (PubMed:29872026). Accumulates in roots, especially during flowering (PubMed:29872026). Expressed constitutively in stems (PubMed:29872026). In capsule walls and contents, present only at the flowering stage (PubMed:29872026)
+Expressed in the CNS of the late embryo
+Expressed in the epidermis from 2 hours post-fertilization (hpf) to 16 hpf (PubMed:18164260). Expression is then restricted to the anterior of the embryo, in particular epidermal tissues of the neural structures at 24 hpf to 72 hpf (PubMed:18164260). Expressed in the heart, tissue ventral to the head and yolk at 48 hpf (PubMed:18164260)
+Fluctuates in amount during the cell cycle
+During embryonic eye development, first detected at 12 dpc with maximum levels at 19.5 dpc and down-regulation of expression postnatally. In brain, levels increase from 13.5 dpc to postnatal day 6 and decrease in the adult
+Highly expressed at fertilization
+Not found in fetus
+In testis, expression starts at day 12 and strongly increases on day 20 and thereafter, temporally correlating with the first wave of spermatogenesis
+Preferentially expressed during the haploid stages of spermatogenesis
+Detected around the 20 cell stage after the onset of zygotic transcription. Also expressed in adults
+During flowering and seed development, expressed very weakly at 3 days after flowering (DAF) (at protein level) (PubMed:24682961). Expression increases until 9 DAF and remains relatively steady until a sharp decline 23 DAF (at protein level) (PubMed:24682961)
+Higher expression in differentiated adipocytes compared to preadipocytes
+Strong expression in the locular jelly during seed development
+Isoform 1 and isoform 2 are expressed 2-22 hours after zygote formation with highest level at 6 hours. Isoform 2 is expressed at low level
+Strongly expressed in organ primordia and immature organs but weakly in mature organs. Observed in SAM at low levels during the vegetative growth with an increase at the transition to the reproductive growth phase. At the reproductive stage, localized in the young developing flowers. Expressed in inflorescence meristem and is up-regulated during flower initiation and formation of flower organs. Also found in cells that differentiate into pedicels
+Expressed during seed maturation. Expressed at three fruit developmental stages, at early stage (approximately 45 days before harvest), at middle stage (approximately 30 days before harvest) and at final harvest stage. Expressed more in ripe than in unripe seeds (Ref.12). Expressed in raw seeds (PubMed:15233621, PubMed:19006093, PubMed:22616776, PubMed:22812192, PubMed:23411333)
+Detected in embryos at 15 dpc and 17 dpc. Expressed in kidney, skin and liver of 16.5 dpc embryos
+Present in vegetative cells but expression decreases rapidly after the initiation of development. Accumulates also in prestalk cells
+Expressed in developing seeds 3 to 4 days after flowering (DAF) in the micropylar region of the endosperm. At 6 DAF, expressed the micropylar pole. At the globular stage of embryo development, expressed specifically in the endosperm and then extends to the chalazal pole of the endosperm at the torpedo stage. The expression decreases at the upturned-U stage, 9 DAF, as the endosperm becomes limited to a few cell layers embedding the maturing embryo. Expressed in the embryo at the later stages of development
+In the embryo, highest levels occur at day 7
+Expressed in lodicules and stamens from early to late stage of flower development
+In seedlings, expressed in hypocotyl and in the entire cotyledon. Observed in all types of cells in the root apex, but restricted to vascular tissue in the upper part of the root. Stronger expression in young leaves than in old leaves. Accumulates in all flower organs, including the sepal, petal, stamen, and gynoecium. In the silique, high levels at both ends but weak in the middle
+The expression of isoform L and isoform M is cell cycle regulated: induced in S-phase, decreases through G2/M, and becomes constant through G1
+Not expressed after germ-band retraction
+Isoform 1 is embryo-specific. Isoform CM1 is male-specific. Isoforms MS3, MS11 and MS16 are female specific. Isoform 1 is expressed for a brief period during the syncytial blastoderm stage. Isoform MS11 is expressed in 4-7 hours embryo
+In the developing brain, expressed at low levels from 10 dpc stages to young adulthood (P25) with peak levels from 14 dpc to P8
+Detected in embryonic epidermal cells; expression increases during neurula and tailbud stage and decreases again after 1 week dpf (at protein level) (PubMed:15537792). First detected in gastrula-stage embryos; expression increases during later stages of embryogenesis. Detected in epidermis and throughout the embryo
+Ubiquitously expressed during all embryonic stages, third instar larval imaginal disk, early pupal stages and in the adult (at protein level)
+Present in reticulate bodies (RB) not detected in elementary bodies (EB) (at protein level)
+Produced during growth but not during development
+First expressed in embryos at 8.5-9 days in facial and branchial arch mesenchyme, otic vesicles and frontonasal ectoderm around olfactory placodes, a day later expression is seen in the developing forebrain in primordia of the ganglionic eminence and ventral diencephalic regions. In day 12.5 embryos, expressed in the brain and bones, and also in all skeletal structures of midgestation embryos after the first cartilage formation. Expression remains unaltered in both brain and skeleton in day 15 embryos and slowly decreases in day 17 embryos
+First expressed in early pachynema nuclei during meiotic prophase I in the gonad (PubMed:34252074). Expression increases in throughout mid pachynema and decreases in the late stages of pachynema (PubMed:34252074)
+Highest activity is during the mid-phase of lactation
+Expressed in the cortex and cerebellum at 18 dpc
+Expression first occurs in a subset of epithelial cells within the single-layered, undifferentiated ectoderm of embryonic day 10.5 mouse fetuses (PubMed:9786956). In the ensuing 48 hours, K17-expressing cells give rise to placodes, the precursors of ectoderm-derived appendages (hair, glands, and tooth), and to periderm (PubMed:9786956). Expressed in hair follicles and in the basal and suprabasal layers of the interfollicular epidermis at birth (PubMed:11408584)
+Expressed throughout development. Increased expression in the shoot apex during the transition to flowering. Induced in the inflorescence vasculature and young flower buds as flowering commenced
+Expressed both maternally and zygotically throughout embryogenesis, and also in adults
+Transcripts accumulate when morphogenesis begins with mesenchyme cell ingression and gastrulation. Accumulation in all cell types of the embryo, although hybridization shows that they are somewhat enriched in cells of oral ectoderm and endoderm. Isoform 2 transcript is enriched in endomesoderm
+Regulated in a cell cycle-dependent manner: expression increases in late S phase and reaches maximum in G2 at the nucleotide level (PubMed:8812457). Not regulated during the cell cycle (at protein level) (PubMed:11073952)
+Present in low amounts during growth and early aggregation, but increase during development and reach its highest level at the tipped mound stage (at protein level)
+Expressed both maternally and zygotically throughout development to adulthood with highest levels at the end of larval development. Expression in embryogenesis is correlated with the formation of a brush border within the alimentary canal. Detected in the developing hindgut and midgut in stage 12 and stage 14 embryos (at protein level) (PubMed:16598258). In third instar larvae, detected in a symmetrical, double chevron-like pattern in the ventral section of segment A8 of the male genital disk, with one chevron in the anterior and the other in the posterior part of this segment (PubMed:16598259, PubMed:22491943). Detected in the H1 domain of the larval imaginal disk (PubMed:26073018). Detected in embryonic anterior and posterior midgut, hindgut, and in salivary gland (PubMed:25659376)
+Expression is cell-cycle regulated, it starts to accumulate in mid-G1 phase, reaches a peak at the G1/S boundary, and decreases to a basal level in S phase (at protein level)
+Abundantly expressed in the early larval stages with lower levels at later larval and adult stages
+Expressed in the suspensor of globular stage embryos
+During limb development, at 14.5 dpc, expressed in the mesenchyme, but not in the overlying ectoderm of the limb bud. In developing lungs, at 14.5 dpc, expressed at low levels in both the epithelium and mesenchyme lineages
+Expressed up from the gastrulation stage, maximal concentration during the prism stage and diminishing concentrations in the differentiating myocytes
+Expressed in leaf primordia, vascular bundles and radicle of the embryo. At the vegetative stage, expressed in crown root and shoot apices. In the shoot apex, first expressed in the leaf plastochron 1 (P1), and then P2, P3 and P4 primordia. Not expressed in the shoot apical meristem (SAM). In the early reproductive phase, expressed in bracts and external layers of the rachis meristem. At the late stages, expressed in branch meristems, floral meristems and floral organs
+First detected at 2.75 hours post-fertilization/hpf (PubMed:27235108). The expression increases at least till 24 hpf (PubMed:26056731). During the segmentation period expressed in the adaxial cells and the somites in a striping pattern (PubMed:14516702). By 24 hpf, expression in the somites decreases except in the tail region. In addition expression is also detected in lens placode and lens fiber cell from 18 hpf till 48 hpf and then decreases to disappear at 60 hpf (PubMed:14516702)
+Expressed in larval stages L1, L2 and L3 and in adult animals with high expression during molting (at protein level)
+Liver from adult female rats contains about 10-fold greater levels of YC2 than is found in liver from adult male rats
+Shows highest expression during pupal stages, with a peak during pupal day 1. Has relatively low expresson during larval development
+Present in the vegetative phase and decreases with the start development, reappears in low levels when the fruiting body is formed
+Expressed in the digestive tract throughout development in the epithelia of proventriculus and glandular structures. In 13 day embryo, strongly expressed in esophagus with moderate expression in proventriculus and lung. Weak expression in gizzard, small intestine, lung and dorsal skin. In embryos over 13 days old, observed in ectodermal, endodermal epithelium and also in neural and mesodermal tissues (i.e. notochord), floorplate in the neural tube, somatic mesoderm, splanchnic mesoderm and dermatome. In more developed embryos, expression was localized in the anterior lobe of the pituitary gland, notochord and hypothalamus of the diencephalon (derived from the floor plate of the neural tube). Also localized in the mesonephric mesoderm and lateral plate mesoderm
+Expressed in cerebral cortex and hippocampus at embryonic day 18 and postnatal days 1, 7, 14, 28 and 56
+Expression begins during gastrulation, increases continuously until stage 26 and then becomes slightly down-regulated during the following stages
+Associated with the differentiation of male gametic cells during pollen maturation
+Detected first in each somite at the 7-somite stage (12 hpf). By 24 hpf, expressed in each newly formed somite. Expression persists at low levels in each maturing somite until after 35 hpf. At 20 hpf, detected in the hindbrain and in olfactory cells
+Transcription is first detected just prior to gastrulation
+Expressed in day 3 embryo
+Active in meristematic tissues. During vegetative growth, expressed in root and shoot apical regions, leaves and roots primordia, root vascular cylinder and procambium. In reproductive organs, present in developing floral meristem, meristematic tissues of young flower buds, and placentae, pollen, ovules and seeds, mostly in embryos. High expression in the earliest stage of silique development, with a decrease during the middle stages of silique development and subsequently an increase during the later stages. In mature seeds, mostly localized in hypocotyl and radicule. During seed germination, first observed in the tip of the radicule and, upon opening of the cotyledons, expressed in the radicule and hypocotyl/radicule transition zone
+Not expressed in embryos, but is expressed in the AIB interneuron region of the head during all larval stages of development
+In stage 16-17 embryos, expressed in the epidermis, tracheal system, Malpighian tubules, boundary cells of the hindgut, muscles and dorsal vessel. Expressed in large puncta in the hemocytes. Expressed in the fusion cells of the tracheal branch tips (PubMed:27323327). Detected first in early pupae and has very high levels of expression in the adult head (PubMed:9813038)
+Highest expression in larvae and adult. To a much lesser extent in pupae
+Highly expressed in the developing brain at 12 dpc-13 dpc when neurogenesis starts. Expression decreases during later development and is undetectable in adult brain
+Accumulates in root cells that are adjacent to intra-radical fungal hyphae or in cells that harbor them during arbuscular mycorrhizal (AM) symbiosis, especially in epidermal and cortical cells (PubMed:19220794). During symbiosis with Rhizobia bacteria (e.g. Mesorhizobium loti), induced in nodules (PubMed:19220794)
+Expressed throughout the life cycle, in oocyst sporozoites that invade the mosquito salivary glands, salivary gland sporozoites infectious to the mammalian liver, and schizonts/merozoites that invade erythrocytes
+Similar expression pattern in larval and adult cells with expression in neuronal, muscle, hypodermal and supporting cells (PubMed:17267616). Temporally expressed in seam cells from the middle of larval stage L4 and throughout adult stages (PubMed:18262516, PubMed:28933985)
+Present at similar levels in seedlings and mature plants
+Expressed constitutively in homokaryons
+Up-regulated in adult heart (at protein level)
+Transcript peaks at G1/S transition
+Expression varies throughout the cell cycle, with the highest expression in G1 phase before septation. Expression is also increased after S phase arrest
+Highly expressed in parasitic larvae (cercariae)
+First detected after 12 hours of development. Highly expressed after this throughout the development of the fruiting body. Detected exclusively in prespore cells, but not in prestalk cells
+First detected in the notochord at 10 hours post fertilization (hpf). At 12 and 14 hpf (the 6- and 10-somite stages), expressed in the notochord, somites and tail. At 14 hpf, also expressed in the forebrain and the lateral plate mesoderm anterior to somite 1. At 18 and 24 hpf, predominantly expressed in the tail, presumptive pectoral fin bud regions and the alar plate of the hindbrain
+Detected in siliques at nucleotide level from 6 days post anthesis (dpa) to 17 dpa. First observed in siliques at protein level 12 dpa and accumulates progressively as native isoforms or proteolytic fragments during the last week of seed maturation/desiccation. Present in dry seeds, but disappears during their germination (at protein level)
+Expressed in the prestalk cells types pstAB and pstAO or at the stalk entrance during culmination, this expression being absent in the dstA null mutant
+First detected at 6.5 dpc in the primitive streak region of the epiblast and extraembryonic vasculature. Expression in the 8.5 dpc yolk sac is seen within blood islands and the capillary plexus. As embryogenesis proceeds, expression becomes prominent in the blood islands and the primitive blood vessels of the yolk sac. By 8-8.5 dpc, a more generalized expression pattern is seen in the neural folds and caudally in the presomitic mesoderm and primitive streak regions. A definite increase in vascular expression is seen in the embryo by 9.5 dpc. Tissue-specific expression is initially seen from early 9.5 dpc in the anterior-most regions of the head, mainly in the optic vesicle and branchial arches. At 11.5 dpc and 13.5 dpc, strong expression is seen in the embryonic stem cells of the blood vessels, especially in the capillaries of the brain and in the hyaline vasculature of the eye. Weak expression is also seen in the lingual vessels and in the neural crest-derived regions of the jaw. A rapid increase in expression in the trunk is seen between 9.5 dpc and 10.5 dpc and by 13.5 dpc, expression is more localized. Expression is not detected in the embryonic heart at early 9.5 dpc and from 11.5 dpc onward, increasing expression is seen in the atrium, ventricle, and outflow tracts of the heart
+Expressed in neural progenitors of the ventricular zone (vz) during CNS development, but that expression is down-regulated during neuronal differentiation. By contrast, neural progenitors located in specific subdomains of the vz maintain expression as they differentiate and migrate away into the emerging nervous system. These have characteristics consistent with the acquisition of a glial rather than neuronal fate (at protein level) First detected in the neuroepithelium of the head folds at 7.5 dpc. Expression is strongly present ventrally in the nascent brain and neural tube of 8.5 dpc and 9.5 dpc and in the heart of 8.5 dpc. Isoform 1 is expressed in early embryos, while isoform 3 and isoform 4 are found in late development when myelination begins
+Strongly expressed in the snout, limbs and eye of 11.5 dpc and 12 dpc. Strong localization of the protein in the lens of the developing eye at all three stages
+Expressed in the midgut goblet cell cavities at the 5th instar larval stage (at protein level) (PubMed:26041352). At the pupal stage, expressed in the midgut and to a lesser extent in the fat body, hemocyte, head and testis (PubMed:26041352, PubMed:30262999). At the pupal stage, highly expressed in ovary (PubMed:30262999). Expressed at the late 4th instar larval stage, and disappears during the 4th molting stage (PubMed:22215981). Highly expressed at the early 5th instar larval stage, then expression remains low during the feeding stage, and increases at the wandering stage (PubMed:22215981). During pupal development, expression begins at prepupal stage 1 (PP1), increases until P4 pupal stage, then decreases after P6 pupal stage (PubMed:26041352). During egg maturation, expressed at low level during the vitellogenic stages and increases at the onset of choriogenesis (PubMed:30262999)
+Expressed in fetal heart, kidney and lung
+No transcripts for RAS2 were detected in any developmental stage
+Expressed in L1, L3, and adult male and female worms
+Expressed during spermiogenesis
+Neurula onwards
+Very little protein is seen in green leaves, the proteins detected were 170, 140 and 110 kDa. 170, 68 and 59 kDa proteins are seen in immature fruit, while more mature fruit and flowers have only the 68 and 59 kDa proteins. It is not clear which parts of the protein are stably expressed
+Expressed at embryonic day 18 specifically in cornified epithelium in the suprabasal layers
+Expressed ubiquitously at 18 hours post-fertilization (hpf)
+Developmentally regulated in the intestine
+Expressed only in the mother cell compartment of sporulating cells
+Expressed from the late torpedo stage to late cotyledon stage in developing embryo
+Rapid decrease in leaves from the leaf opened to the green fruit stage (PubMed:30577538). Slight increase in roots from the leaf opened to the green fruit stage (PubMed:30577538)
+Expression strongly increases from 9.5 dpc, peaks between 11.5 dpc and 13.5 dpc and diminishes slowly thereafter. Expressed in the somites during segmentation, limb bud mesenchyme, and developing central nervous system. Expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm and somites
+This histone is a testis-specific H1 variant that appears during meiosis in spermatogenesis
+Expressed both maternally and zygotically during all stages of development, highest expression during adult stages
+It appears first at 13.5 dpc and increases until birth
+Expressed throughout all stages of development
+In the testis, present in cells undergoing meiosis I. Not detected in peripheral cells in seminiferous tubules that are undergoing pre-meiotic DNA synthesis or in late condensing or mature sperm
+Expressed in calvaria at 16.5 dpc
+Expressed during fruit ripening, but not during fruit development (PubMed:18359841, PubMed:18427769). Expressed during leaf senescence, but not during leaf development (PubMed:18427769)
+During embryo development, expressed exclusively in endothelial cells from the pre-embryo up to the heart stage. Expression disappears when the endothelial cells undergo PCD in the early-bent cotyledon stage (at protein level)
+Most abundant at 2-8 hours of embryonic development
+Expressed in rice seeds between 2 and 4 weeks after flowering
+Highly expressed in neuron-enriched regions of the developing brain, but down-regulated to low levels in the adult brain
+Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus
+Isoform 1 is present from 14 dpc. Isoform 3 is present from 18 dpc (at protein level)
+First detected in myocardium at HH stage 14. Detected in myocardium and somites at HH stage 17 and 19
+Up-regulated upon the maturation of CD4/CD8 double-positive to CD4 single-positive thymocytes
+Up-regulated during leaf senescence (at protein level)
+Begins to be highly expressed around postnatal day 5 in the outer retina when the photoreceptors begin to differentiate and rapidly increases in expression to reach the mature adult level by postnatal day 23
+Expressed in most cells of the cleavage stage embryo, apart from a few cells at the posterior pole, from the 20 cell stage to the 200 cell stage (PubMed:12568714). Expressed in all descendents of the AB and EMS founder cells (PubMed:12568714)
+In roots, repressed except during flowering (PubMed:29872026). Accumulates in leaves and stems during flowering (PubMed:29872026)
+Expressed in the anterior part of comma-stage embryos (PubMed:11476572, PubMed:18313275). In larvae, expressed strongly in almost all anterior hypodermal cells and weakly in many head neurons (PubMed:7659159, PubMed:18313275). Expressed in the gonadal DTCs during ventral migration in hermaphrodite L4 larvae (PubMed:17606640, PubMed:18313275). Expressed in the male hindgut, in B.a and Y.p sensory organ precursors, from the early L2 and until the mid L3 larval stages (PubMed:18313275). Expression diminishes in the B.a lineage during late L4 tail morphogenesis, and is absent in adults (PubMed:18313275). Expression in the Y.p lineage diminishes in the mid L3 stage (PubMed:18313275). Male hindgut expression is restricted to specific lineages in a lin-48 and egl-38 dependent manner (PubMed:18313275)
+First expressed at about 5 hours of embryogenesis in 20-30 anterior dorsal cells, corresponding to the hypodermal cells of the head, and lateral sets of about 10 cells, of which some are probably future head neurons (PubMed:7659159). By the 1.5-fold stage, expressed in hypodermal and neuronal cells in a broad region of the head (PubMed:7659159)
+Expressed in RS.a and RB.p in late larval stage L3, in ray 6 and ray 8 cells in late L4, in neurons descended from P11.a in the preanal ganglion in L4 males and head hypodermis and a pair of bilaterally symmetrical neurons in the head anterior of the nerve ring in L4 males (at protein level) (PubMed:7659160, PubMed:9858725). Also expressed in seminal vesicle cells in late L4 males (at protein level) (PubMed:9858725)
+Developmentally regulated; with a peak of expression at 16 hours corresponding to the finger stage of development
+In ovaries, it is detected at high levels in vivo on day 10, with a subsequent decrease on days 15 and 20, in adult and old ovaries. Weakly expressed on day 5
+Transiently expressed in the stroma and endothelium of the cornea at birth. Subsequently expressed in the corneal epithelium and the inner nuclear and ganglion cell layers of the retina. The predominant form in developing ocular tissues is isoform 2, although isoform 1 is also detectable
+In roots, expressed only in the quiescent center (QC), the columella stem cells (CC) and the innermost layer of central columella cells; mostly present in the third and fourth CC layers, but not, or only marginally, in the QC (PubMed:20798316, PubMed:22307643, PubMed:23370719). Induced during lateral root formation (PubMed:23370719). Accumulates in pollen grains (PubMed:23370719)
+Expression first seen at the 8E cell stage in the embryonic gut. After hatching, expression is almost diminished in the pharynx and gut. Expressed in L3/L4 larvae in cells of the developing gonad. At the 8-12E stage, expression is seen for the first time in the rectal precursors. Intestinal expression is down-regulated during the larval to adult transition
+Up-regulated during flower development
+Expressed very early during development of the mouse embryo. Expression is higher in testes, ovary, and the developing nervous system relative to other tissues
+First observed in roots and cotyledons of young developing seedlings. Later confined to root tips and cauline leaves tips. In flowers, detected in the stamens and at the senescence region of developing siliques
+Increased expression in S phase and mitotic cells; levels decrease as cells enter in G0/G1 phase due to proteasomal degradation (at protein level)
+First detected at the anterior position of the embryo at the first somite stage. From the late segmentation and pharyngula periods, expressed in a region ventral to the forebrain, and in the midbrain, hindbrain, and spinal cord. Expressed in the prospective extraocular muscles, mesencephalic neurons residing along the tract of the posterior commissure and interneurons in the spinal cord
+Appears in mid-proliferation phase when the developing gut has four to eight cells
+Expressed at 9.5 dpc and 13.5 dpc
+Expressed from the end of gastrulation
+Isoform 1 is expressed at all developmental stages with highest levels during the first two weeks after birth when migration of neurons and formation of dendrites and axons is highest. Within the developing brain the highest level is found in granule neurons in the initial stages of migration. Also found in soma and dendrites of developing Purkinje cells
+Synthesized in unfertilized egg, but no longer made in the early embryo
+Expressed both maternally and zygotically. Expression is lost before gastrulation and begins again during early somitogenesis
+Low levels detected at 16 dpc through P10, and increased between P10 and P15 during the development of brain; the amount did decrease in the adult brain
+At 15.5 dpc isoform 1 is expressed predominantly in the skin and in the developing hair germ, isoform 2 is expressed predominantly in the epidermis
+Expressed throughout growth and development
+Expressed in developing embryo as well as in adult
+Expression is first detected at 12.5 dpc
+The parasporal crystal protein is produced during sporulation and accumulates as a spore inclusion; crystals are separated from the forespores by a branch of the exosporium across the cell. The matrix of the paraspore is dissolved within 15 minutes following Culex quinquefasciatus larvae feeding
+Weakly expressed in embryos, larvae and adult females. Strong expression in adult males
+Cell cycle-regulated with highest level in G2 phase
+Expression begins around stage 18 (late neurula)
+Weakly expressed in late gastrula. Strongly expressed from late neurula (stages 20-22) to tadpole (stages 40-41). At stage 22, expressed in blood islands, somites, eyes, trunk neural crest, mandibular crest segment, hyoid crest segment and branchial crest segment. At stage 32, expressed in otic vesicle, pronephros, forebraiin, midbrain, hindbrain, branchial arch, eyes, lens, spinal cord and notochord
+Highly expressed in root pericycle and cell suspension culture during cell cycle arrest. Expressed early in the G1 phase, disappears quickly and starts to increase again to reach a peak before mitosis
+Expressed in embryos (PubMed:9508766, PubMed:18652816, PubMed:26492166). Abundant in early embryos, but displays a progressive decline throughout the four larval stages, and is subsequently up-regulated in the adult (PubMed:9508766, PubMed:26492166)
+Its expression starts at 30 days of age, reaches a maximum during the sexually mature period, and then decreased in old rats
+Expressed exclusively within vegetative cells
+Expressed in fetal brain, liver, lung, kidney and placenta
+Up-regulated in senescing leaves and maturating seeds
+Expressed at 120 dpc
+Expression starts 5 hours after onset of sporulation and peaks at 6 hours after onset
+Expression begins around the postembryonic birth of VA and VB motor neurons at the late first larval L1 stage, and is maintained throughout the life of the animals
+Ubiquitously expressed throughout early embryogenesis
+Progressive level increase from pod to full-size seed growth
+Present uniformly throughout embryos of stages 4 and 10. In stage 16 embryos, the expression becomes restricted to the central nervous system, the developing gonads, and a portion of the gut. In stage 17 embryos, expression is mainly localized in cells along the midline of the central nervous system
+Accumulates in a circadian fashion, peaking at CT 15-18
+Expressed at highest levels in 2-4 hours embryos
+Present in eggs and early embryos but cannot be detected in late embryos
+Expressed both maternally and zygotically. Zygotic expression occurs in two stages: late blastulation/early gastrulation with greatest expression in the embryonic shield; and during segmentation with expression in the somites and presomitic mesoderm
+Expressed in two-fold stage embryos in the lateral epithelial cells (seam cells) and continues throughout all larval stages. In adults, expression becomes faint in seam cells and strong in intestinal cells. Also weakly expressed in epithelial cells of the vulva. Overall, expression appears to be restricted to certain types of epithelial cells and changes with developmental stages
+Expressed in the prestalk cells type pstAB or at the stalk entrance during culmination and slug stage, this expression being weak in the dstA null mutant
+Expression increases in all brain regions examined with age, and increases markedly in reactive microglial cells amd CA1 pyrimidial neurons following ischemic injury. In the thymus expression increased steadily up to 8 weeks of age before decreasing to a much lower level by 52 weeks. Expression levels in the spleen and stomach do not appear to vary with age
+Expressed mainly in the developing nervous system from 9.5 dpc onwards. Also detected in the developing eye and the brown fat
+Expressed in 2 distinct phases during the embryogenesis. The early phase extends from late blastulation to the completion of epiboly, during which the expression occurs in the superficial layer of the embryos. The second phase of expression starts during mid-segmentation and persists until day 3, during which the expression occurs prominently in the developing lens
+Only expressed in predivisional cells, protein levels drop precipitously prior to cell division
+Expressed in young seedlings
+From 3 dpc, expressed in the olfactory placode, forebrain, midbrain, and lenses. At later stages, expression in the lenses is no longer detectable but is found in the fore- and ventral mid-brain and in the mid-hind-brain boundary. At 5 dpc, expressed in olfactory epithelium and brain
+Expressed in the developing wing bud. At stage 31, widely expressed with a lower level in the heart
+Developmentally regulated at the gastrula stage
+At 24 hours post-fertilization (hpf), detected in the somites, tail bud region adjacent to the fin fold, pectoral fin buds and the head. A similar expression pattern is observed at 48 hpf, although levels are reduced. By 120 hpf, expression is almost completely undetectable
+Expressed in adult but not in larval olfactory organs
+During endosperm development, the expression of GPA3 is low at an early stage, peaks at 18 days after flowering (DAF), and slowly decreases after 21 DAF
+Detected in round and elongating spermatids
+Expressed at stable level during brain development, with a higher level in embryonic brain
+Expressed in the epididymis from 3 weeks of age
+Acts in the early stages of hematopoiesis
+Expressed in tachyzoites
+Expressed in placental trophoblast giant cells from 5.5 dpc onwards, with increased expression by 10.5 dpc (at protein level). Also detected on the decidua basalis at 10.5 dpc (at protein level)
+Isoform 1, but not isoform 2, is expressed in embryos at 13.5 and 15.5 dpc. Isoform 1, but not isoform 2, is expressed in primordial gonads at 13.5 and 15.5 dpc. Isoform 1, but not isoform 2, is expressed in ES cell lines. Isoform 1, but not isoform 2, is expressed in embryonic germ (EG) cells (at protein level). Detected in the embryo and allantoic bud at 7.5 dpc, in the neuroectoderm at 8.5 dpc, and widespread at 9.5 dpc, including the neural tube, head mesenchyme, first branchial arch and the hindgut, through which primordial germ cells are migrating. At 11.5 dpc, also expressed in the XY and XX genital ridges. Expressed in genital ridges at 13.5 dpc. Between 12.5 to 14.5 dpc, up-regulated in the testis cords of the XY gonads and down-regulated in XX gonads. Down-regulation occurs progressively as an anterior to posterior wave
+Synthesized during the last larval stage in peripheral fat tissues and sequestered in the perivisceral fat tissues during larval-pupal transformation
+Expressed from 9 dpc to 16 dpc in the heart, otic region, maxillary and mandibular components of the first branchial arch, nasal processes, eyelid, midbrain, medulla oblongata, limbs, dorsal root ganglia and genital tubercle. Also expressed in non-neuronal structures around the oral cavity and in hip and shoulder regions and in mesenchyme surrounding the vertebrae
+Activity is high in G0, decreases after serum addition, and increases transiently in advanced G1, at G1-S, and in S phases
+Expressed in young seedlings, especially at the tip of the growing shoot meristems. Later observed in roots and in aerial parts. Weakly expressed in leaves with local higher levels in the trichomes and in cotyledon veins. Present at low levels in flowers with higher accumulation in cells at organ-stem junctions. Restricted to the developing peduncle
+Transiently expressed in the very early stages of flower development
+Expressed in fetal muscle tissues at 12.5 dpc
+Expression increases in the cortex from birth to adulthood
+Up-regulated during seed maturation
+Expressed at all stages
+Late embryogenesis, larva and adult
+At 12.5 dpc-14.5 dpc, strongly expressed in radial glial fibers, which are a scaffold for migrating neurons (at protein level)
+In cerebral cortex, spinal cord and sciatic nerve levels are high early in development but decrease during postnatal development and are low in adults. In dorsal root ganglia levels remain high throughout development
+Expressed both maternally and zygotically throughout oogenesis and embryogenesis through to at least the tadpole stage. Also expressed in adults
+Expressed throughout pollen development, both in pollen mother cells and in developing and mature pollen grains. Expressed in growing pollen tube
+Expressed at high levels in early embryos but at low levels in larva, pupa and adult (at protein level)
+Detected at low levels from day 7 to 11 of embryonic development. Levels are much increased and remain high from day 15 to 17
+Maximally expressed during early stationary phase
+Expressed specifically in tapetal cells and microspores during anther development in stages 8 and 9
+Detected in embryos at stages 11-15, but not detected in unfertilized eggs
+Expressed from pre-gastrulation to organogenesis stages (at protein level) (PubMed:12706888). At this stage 7.5 dpc, expression becomes asymmetrical and localizes to all three germ layer regions of the anterior conceptus, suggesting a possible role in anterior-posterior axis patterning (at protein level) (PubMed:12706888). Later expressed in the forebrain (9 dpc and 10 dpc) and in the midbrain (11.5 dpc) (at protein level) (PubMed:12706888). From 9 dpc to 11.5 dpc, expressed in the early craniofacial structures, limb buds and somites (at protein level) (PubMed:12706888). Highest expression is in the face and includes the cranial and caudal regions of the mandibular prominences, the budding maxillary prominences and the roof of the stomodeum (at protein level) (PubMed:12706888). Before gastrulation, 5.5 dpc, expression is initially symmetric and uniform in the epiblast and in the extra-embryonic visceral endoderm (PubMed:7896269)
+In 18.5 day embryos, expressed in the peri-chondrium, periosteum and at the chondro-osseus junction of developing bone
+Late developmental stages
+Abundantly present in fetal skeletal muscle and not present or barely detectable in heart and adult skeletal muscle
+Embryo, L1 and L2 larvae
+Strong accumulation in embryos (at protein level)
+High levels are seen in unfertilized eggs and expression increases slightly during early embryo stages (2-3 hours). Levels are high in embryos until 4 hours after fertilization and then decrease gradually through embryonic and larval stages
+Expressed in the ventral forebrain
+Expressed from early embryogenesis (PubMed:26494905). By 2 days post-fertilization (dpf), enriched in the brain, cardiovascular region, pectoral fin buds and in proliferative cells of the retina (PubMed:26494905). At 3 dpf, expression is maintained in the brain, retina and cardiac regions (PubMed:26494905). By 5 dpf, expression is observed in the head and trunk neuromasts (PubMed:26494905)
+Expressed throughout follicle development with highest level in small white follicles. Expressed in granulosa cells, theca cells and post-ovulatory sacs of developing follicles
+Becomes apparent upon completion of villus formation at 20 days gestation (2 days before birth) and is expressed by the entire epithelium of the villus
+Accumulates during oocyte growth and degradaded after meiotic resumption: present in germinal vesicle (GV) stage oocytes and decreases during meiotic maturation and fertilization, and undetectable in 2-cell embryos
+Expressed in embryos, larvae, pupae, and female and male adults
+In liver, barely expressed at 14.5 dpc, expression dramatically increases at 18.5 dpc. Abundantly expressed in neonate liver but levels strongly decrease in adult liver (at protein level)
+Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM) of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem cells (ES). Expression decreases with ES differentiation
+Expressed during parasite asexual blood stages, specifically in immature trophozoite (ring stage), late trophozoite and schizont stages
+Produced during parasite asexual blood stages, specifically at the late schizont and merozoite stages prior to egress from host erythrocytes
+Expression begins during gastrulation and continues during all subsequent stages
+Expressed in the postembryonic mesodermal lineage (M lineage) at the 4-M to 8-M stages, at similar levels in both the dorsal and the ventral sides (PubMed:18036582). At the 10-M stage and later, expression becomes more restricted along the anterioposterior axis and gradually lost in the anterior M lineage cells, but retained in the posterior M lineage cells (PubMed:18036582)
+Accumulates progressively in glandular trichomes (lupulin glands) after flowering
+Expressed in testis at a high level immediately after birth, and decreases to a very low level by 3 months
+Expressed between 4 and 12 hours post-activation. Protein was detected at cell surface at 24 hours and it's expression was maximal from 48 to 72 hours post-activation
+Expressed in late embryogenesis and into adulthood (PubMed:11532910, PubMed:16310763). Expression in the excretory duct cell begins in the majority of embryos by comma stage and persists throughout larval development into adulthood (PubMed:16310763). Expressed in L1 stage larvae in the excretory duct cell, neuronal support cells of the phasmid and labial sensory structures and a small number of additional unidentified cells in the head (PubMed:11532910, PubMed:12231624)
+Expressed in style and papilla cells when pollination occurs. Detected in the mature embryo sacs of ovules before and after fertilization
+Expression begins during cell cycle progression, between 12 and 24 hours after germination. Reach a maximum around mid-log phase and disappear during the stationary phase
+Expressed in stage P0-P2 spinal astrocytes, stage P15 hippocampus where expression is detected in some pyramidal neurons, and stage P18 cerebellum where strong expression is detected in a few scattered Purkinje cells and weak expression in neighboring Purkinje cells
+Weakly expressed in vegetative cells. Expression increases during development until culmination. Higher levels detected during aggregation and culmination. Enriched in prespore cells
+Expressed during vegetative growth
+Expressed at all embryonic stages examined. Expression was low and distribution was diffuse. At the primitive streak stage, detected in the extraembryonic region. Signal first appeared in the embryo during the neural plate stage. Stronger and more localized expression is seen after embryonic turning. Higher expression is seen in the branchial arch mesenchyme, the endoderm of the developing pharynx, all levels of the developing gut, the myotome compartment of the somites, and some regions of surface ectoderm. At 8.25 and 9.0 dpc expressed in head mesenchyme and ventral mesoderm
+Expressed in pollen during pollen development, germination and tube growth. Expressed during embryo development and young seedling growth
+Higher expression in young leaves. Down-regulated during dark-induced and natural senescence
+During spermatogenesis, it is first detected in testis at 15 days postpartum (dpp). Expressed at higher level at 17 dpp, 20 dpp, 25 dpp and in adult testis. First expressed when primary spermatocytes are present in postnatal mouse testis
+Expressed in the developing fetal lung epithelium and developing brain (at protein level)
+In the testis, expression increases steadily after birth until the first spermatogonial cells appear, levels off as the first spermatogenic cells enter meiosis (10 days after birth) and remains at this level thereafter
+Expressed at the onset of sporulation
+Largest accumulation of transcripts is seen in the posterior two-thirds of the developing leech central nervous system in 7-14 days embryos
+Expressed from 7 dpc and throughout development
+Expressed constitutively during the cell cycle
+It begins to accumulate 6 days after flowering and reaches a maximum level at 14 days
+Expressed at a significantly higher level in postnatal day 1 (PND1) than in PND21 visual cortical
+Highly expressed at 20 dpc. At 17.5 dpc, highly expressed in the cortical plate and basal subventricular zone
+Highly expressed in fetal liver
+First detected within the ventral eye at Hamburger-Hamilton (HH) stage 14 as the optic vesicle invaginates. Expression restricted to the ventral retina at HH stage 22 and at 4 dpc as well as later in development
+Expressed zygotically from the mid-gastrula stage
+Expression changes during the molting cycle with highest expression in the late pre-molt and post-molt stages, intermediate expression in the intermolt stage and lowest expression in the early pre-molt stage
+Expressed in PstA and PstO cells in the slug stage, becoming preferentially restricted to PstO cells during culmination
+Expressed in the precursors of the skeletogenic or primary mesenchyme cells of the early to mid blastula, and thereafter in the presumptive and then definitive oral ectoderm. In the post-gastrular embryo, expressed in apical plate and ciliary band
+At 14 dpc, strongly expressed in cochlear and vestibular hair cells of the inner ear, in the cochlea at 18 dpc and coninues to the adulthood
+Most abundant during and/or after neuronal differentiation and during cell specification or axogenesis. Required during pupation for normal motor function development
+Expression is first observed in the linear heart tube at 8 dpc. The highest expression is in the region that will give rise to the ventricular segments. At 9.5 dpc, the ventricular expression is maintained in the looped heart tube. In the adult, expression is observed exclusively within myocardial cells
+In developing seeds, mostly expressed in early stages
+Expressed at all stages of embryonic and early larval development
+Expressed throughout development, including in the germline and especially in intestine in larval and adult stages (at protein level)
+First expressed in 4-8 hours old embryos, peaks in 8-12 hours old embryos and continues through development up to late larval stage. In the head region, detected at stage 10 in the maxillary and labial segment primordia, and in later stages, in the prospective antennal and mandibular segment. In the epidermis, expression is seen from stage 11 in thoracic and abdominal lateral patches. Expression in the intestinal tract begins at stage 13, continues through stages 14 and 15 in the endoderm of the anterior midgut and at stage 16, is found in the posterior end. Expression in the imaginal disks is seen from late third-instar larvae in the prospective thorax, claw organ, antenna, scutellum and wing blade
+Expression was difficult to detect in immature proliferating chondroblasts or myogenic cells in embryos, but became obvious and prominent concomitantly with the maturation of osteocytes, chondrocytes, and skeletal muscle cells. Expression in these musculoskeletal cells increased with RB1 expression, which is linked to the terminal differentiation of many tissues and cells. The introduction of the wild-type protein decreased the formation of macroscopic colonies in a cell growth assay
+First expressed at the globular stage, mostly in the apical part of the embryo. During the triangular stage, confined to the boundary of emerging cotyledons. Later restricted to the center of the apical part of the embryo and to seedling apex, at the boundaries of the cotyledon margins and the boundaries between the SAM and the cotyledons. Localized in a one-cell-wide ring at the boundary between trichomes or lateral roots and epidermis. Accumulates at the boundaries between leaf primordia and the shoot meristem and between floral primordia and the inflorescence meristem. Found in the adaxial axils of secondary inflorescences and pedicels, and in axiallary buds. In flowers, expressed in a ring at the bases of sepals and petals. In carpels, confined to the boundaries between ovule primordia. In ovules, localized in a ring at the boundary between the nucellus and the chalaza. In the mature embryo sac, detected in the two polar nuclei of the central cell
+Expressed in the dorsal root ganglia and in the spinal cord at 9.5 dpc (PubMed:18709437). Expressed in the neurons that innervate the limb buds at 13 dpc (PubMed:18709437). Expressed in the dorsal root ganglia and the sciatic nerve at 13.5 dpc (PubMed:23179371). Expressed in type I and type II spiral ganglion neurons of the cochlea at postnatal days P1 to P7 (PubMed:20132868)
+Expressed within the ventricular, periventricular and subventricular zones at 12.5 dpc; olfactory epithelium, radial glial fibers, cortical plate and lateral ventricles at 16 dpc; in a lesser degree in lung, renal cortices and alimentary tract
+Low level expression in brain up to 15 dpc, higher level expression from 18 dpc to P14 with highest level around P4 (PubMed:17439943). Low level expression in adult brain (PubMed:17439943). Low level expression in hippocampal neurons up to stage 2 in culture (PubMed:17439943). Higher level from stage 3 with highest level of isoform 1 on day 7 in vitro (DIV7) (PubMed:17439943). Phosphorylated isoform 1 from DIV7 with high level up to DIV28, isoform 2 detectable from stage 3 to DIV7 (PubMed:17439943)
+Expressed in embryos and early-staged larvae (PubMed:7954812). Also expressed in adult gut nuclei (PubMed:14660541)
+Expressed throughout the life cycle
+Expressed both maternally and zygotically. High expression in embryos and third instar larvae, lower expression in pupae
+Expressed during somatic embryogenesis in nursing cells surrounding the embryos but not in embryos. Accumulates in mature pollen and growing pollen tubes until they enter the receptive synergid, but not in endosperm and integuments. In adult plants, present in hydathodes, stipules, root epidermis and emerging root hairs
+During spermatogenesis
+Accumulates during flower development with highest levels in open flowers, at anthesis, and fades out as flowers are senescing
+Expressed in actively growing cells and repressed quickly when these cells were induced to differentiate
+Expressed in vegatatively growing cells. Expression increases upon starvation from and remains high until fruiting body formation
+Expressed mainly at the end of seed maturation when the tissue is completely dry
+Zygotic expression begins at the late gastrula stage, increases during neurulation and becomes most abundant at tailbud stages, then continues at a lower level in tadpoles
+Accumulates in developing seeds in siliques, mainly in the seed coat and, to a lesser extent, in the embryo
+During embryogenesis, expressed in a discrete domain within the mandibular component of the first branchial arch and later in the primordia of middle earassociated bones, the gonium and tympanic ring
+Expressed in last instar larvae
+Expressed throughout development and in the adult. Highest level of expression observed during late embryogenesis
+Highly expressed during bolting
+Is expressed prior to 10 dpa (days post anthesis), accumulates to the highest levels between 20 and 35 dpa and levels decrease after 35 dpa
+Expressed in 7 day- and 14 day old seedlings
+Expression detected from HH stage 4
+Detected at the cleavage and blastula stages, 1.75-4 hours post-fertilization (hpf) (PubMed:21880859). Expressed in forebrain, midbrain, hindbrain and cells lining the brain ventricles at 19-22 hpf (PubMed:21880859). Expressed in midbrain and otic vesicles at 26-36 hpf (PubMed:21880859). Detected in bilateral domains in brain near the hypothalamus, and in heart, at 48-72 hpf (PubMed:15297442, PubMed:21880859)
+Expressed in the embryo from day 7. After day 15.5, expression decreases and disappears completely by the time of birth
+Only detected in the salivary glands of adult female ticks between 2 to 4 days after attachment to the host animal. Is not obtained from nymphs, larvae or adult male ticks. Is only detected in a quarter of pairs of glands, suggesting non-continuous production of the protein or slow repletion of stocks following salivation
+Expressed in the ventricular and subventricular zone progenitor cells of the dorsal and ventral forebrain and the brainstem, at 12.5 dpc, 14.5 dpc, and 17.5 dpc. At later embryonic age, it is observed in neurons of the cortex and hippocampus. During postnatal development, expression is detected in the cerebral cortex, basal ganglia, hippocampus, thalamus, and external granular layer of the cerebellum
+Accumulates in heterocysts (at protein level)
+Abundantly expressed in granule neurons at all developmental stages
+Abundant in early stages of oogenesis after which it is nearly constant
+In placenta, detected at higher level during early pregnancy and at lower level during late pregnancy
+Expressed both maternally and zygotically. Expressed throughout embryonic, larval, pupal and adult stages, with increasing levels during larval development
+Expressed both maternally and zygotically in oocytes and embryos through to swimming tadpole stages
+At 14 dpc, expressed in the intermediate zone of the cortex (PubMed:9096138). At 15 dpc, high expression in the neocortex, with decreased expression at postnatal day 7 and in adulthood (PubMed:24599466). At 16 dpc and at birth, expressed in the retina, thalamus, hypothalamus, midbrain, pons, dorsal and ventral spinal cord, and the dorsal root ganglia (PubMed:9096138). At birth, expressed in the nasal epithelium, olfactory bulb, trigeminal ganglia, cerebral cortex, the pyramidal cells of the hippocampus and the sympathetic ganglia (PubMed:9096138). Widely expressed in the cerebellum at postnatal day 9 (PubMed:9096138). Isoform 4: Highly expressed in the brain at 10 dpc to 14 dpc, with decreased expression at 16 dpc and at postnatal day 8 (PubMed:9096138). Isoform 5: Highly expressed in the brain at 10 dpc, with decreased expression at 16 dpc and at postnatal day 8 (PubMed:9096138). Isoform 6: Expressed in the brain at 14 dpc (PubMed:22895702). Isoform 7: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 8: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 9: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 10: Expressed in the brain at 14 dpc, including the amygdala, hippocampus and cerebral cortex, and strong expression in the olfactory bulb and retina (PubMed:22895702). Isoform 11: Expressed in the brain at 14 dpc (PubMed:9096138)
+Expression detected in trophoblast giant cells (TGCs), the placenta-derived cell lineage aligned at the boundary between the uterus and placenta, at embryonic days 12.5 (12.5 dpc). However, expression is faint and only observed in some of these cells, and disappears by 15.5 dpc
+Expressed during the postmeiotic stages of spermatogenesis. Detected at least at 14 dpc, the expression being enriched in kidney and small intestine. Within the nervous system, expression is prominent in the most superficial layers of the posterior cerebral cortex at 14 dpc and retina at 18 dpc. Expression is enriched in the posterior cerebral cortex at birth and declines at 7 days after birth
+Expressed at preprocambial stages first in wide domains, and later confined to sites of vein development
+During embryonic development, detected in the left-right organizer at 8.25 dpc and in 17.5 dpc embryos, detected in epithelial cells lining the respiratory tract, brain ependymal cells and the choroid plexus
+Expressed throughout the embryo during all steps of embryogenesis, and decrease toward the bent-cotyledon stage. Higher levels in tissues undergoing primary cell wall formation, and drop of expression when secondary wall synthesis takes place. High levels in developing seedlings and elongating stems, with a decrease at later growth stages
+Primarily expressed in amastigotes
+Expressed late in development
+Expressed from 0 hours to 12 hours upon starvation (at protein level). Expressed in the polar region during cytokinesis
+Expressed in embryonic and in larval L1, L2, L3 and L4 stages, and in immature adults (PubMed:10191044). Earliest expression detected in eight cells on the posterior dorsal surface of the embryo, probably granddaughters of Cpaa and Caaa, approximately 240 min after the first cell cleavage (at protein level) (PubMed:10191044). At approximately 260 min after the first cleavage, expressed in cells on the dorsal, and ventrolateral, surfaces of the embryo; these are probably hypodermal and ventral hypodermal cells (P cells), respectively (PubMed:10191044). Expressed in comma stage embryos, at about 350 min, in all the dorsal (hyp-7) and ventral (P1/2-P11/12) hypodermal cells in the main body region; also in hypodermal cells of the head (hyp-4, hyp-5, and hyp-6) and tail (hyp-8, hyp-9, hyp-10, and hyp-11) (PubMed:10191044). No expression is seen in the lateral hypodermal cells (seam cells; V1-V6, H0, H1, H2, and T) or the minor hypodermal cells of the head (hyp-1, hyp-2, and hyp-3) (PubMed:10191044). Expressed from the 3-fold stage of embryogenesis onward in two cells, probably the vpi3 cells of the pharyngeal-intestinal valve, immediately anterior to the gut (at protein level) (PubMed:10191044). Also expressed in five cells immediately posterior to the gut, probably the intestinal-rectal valve cells (virL and virR) and the rectal epithelial cells (rect D, rect VL, and rect VR) (at protein level) (PubMed:10191044)
+Isoform alpha and isoform beta are expressed both maternally and zygotically. Zygotic expression is present throughout embryogenesis and fades by first larval instar. Expression levels at all stages are low
+Haustoria and rust-infected leaves. Also observed in non-germinated spores. After germination, expression stopped
+Expressed in vegetative cells and heterocysts, however the expression is higher in vegetative cells than in heterocysts
+Expressed during the asexual blood stage specifically in trophozoites and schizonts (at protein level)
+Expressed maternally. Accumulates during the latter stages of oogenesis and levels increase three-fold during oocyte maturation. Levels decrease after fertilization
+Expressed during early seed development
+Expressed in embryos at stage 13 in tracheal fusion cells (at protein level). During embryonic stages 15 and 16, detected in the dorsal and lateral trunks, in the visceral and dorsal branches and in the transverse connective branches (at protein level). In the larvae, continuously expressed in the entire tracheal system (at protein level)
+Mature seed in dormancy
+Originally expressed in the trophoectoderm of the blastocyst and later in the extraembryonic ectoderm of the early post-implantation embryo. In the embryo proper, expressed in the posterior part of the epiblast. During gastrulation, extends distally into the primitive streak and nascent mesoderm. Also expressed in the developing forebrain and the olfactory lobes. Expressed at 12.5 dpc and 14.5 dpc in the forebrain
+Highly expressed in the female germline
+Expressed throughout cortical development culminating at P1. Expression is reduced but still present in the adult cortex. Expressed in the cortical wall both in neuronal progenitors in the ventricular zone and post-mitotic neurons in the cortical plate (at protein level)
+Detectable in crown cells of the embryonic node from 7.5 dpc. Initial uniform expression develops asymmetrically with a higher level on the left side of the node until expression disappears around 13.5 dpc. Expressed in antrum pyloricum of the stomach from 11.5 dpc to 16.5 dpc and in dorsal tongue epithelium from 14.5 dpc to 16.5 dpc
+Expressed both maternally and zygotically. At the early gastrula stage, expressed mainly in the entire animal hemisphere. During neurulation, its expression becomes restricted to the anterior neuroectoderm. At the tailbud stage, expressed in various anterior regions including the anterior central nervous system (CNS), otic vesicles, and branchial arches
+Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the second or third lumbar pre-vertebrae
+Expression begins in floral buds after pistil differentiation and levels gradually increase during flower development toward anthesis. Levels gradually decrease after pollination and are absent by the sixth day after pollination
+Expressed in the shoot meristem during vegetative to reproductive phase transition
+Expressed in the embryo from day 15.5
+First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative
+Expressed in immature grains. Decreases during maturation and then increases again during germination
+Expressed both maternally and zygotically. Expressed at low levels during cleavage stages, with zygotic expression increasing at the start of gastrulation, remaining constant through the gastrulation stages and then decreasing from late neurula stage onwards
+Expression increases during embryonic or postnatal brain development from cerebral cortex at 14 dpc to P7 stage
+Expressed in germinating seeds 3 to 5 days after imbibition
+Detected in the mantle layer of the neural tube and in the dorsal root ganglia at 14.5 dpc
+The expression level of the transcript is highest in vegetative cells and in early development (5 hours), and decreases at 5 to 10 hours of development. Inn contrast the protein level does not significantly change during the life cycle, despite the marked reduction in the level of mRNA after 5 to 10 hours of development, suggesting that the protein is stable throughout the life cycle
+During adipocyte differentiation, levels are elevated two-fold (at protein level)
+Expressed in the gonadal distal tip cells (DTC) during larval stages L2, L3 and L4
+During male gametophyte development, expressed at the polarized microspore stage, bicellular stage, mature pollen stage, anthesis stage and open flower stage. Expressed in germinating pollen grains and elongating pollen tubes
+Expression peaks early in embryonic development and decreases during later stages
+Expressed at high levels in all stages of embryonic development analyzed (7 days to 17 days)
+Expressed both maternally and zygotically throughout development. Highest expression is in early embryos and third larval instar
+Expressed in the developing eye, brain and ear during embryogenesis
+Expression in testis begins at about postnatal day 10 (P10), with adult level of expression reached at P20
+Expressed in the mesoderm adjacent to the node and primitive streak during early gastrulation (PubMed:9106168). At the headfold stage, mesodermal expression is restricted to posterior regions up to the base of the headfolds (PubMed:9106168). From 10.5 dpc onwards expressed within the spinal cord in cervical and lumbar regions adjacent to the developing limbs, as well as in specific regions of the developing head, including the tooth buds, inner ear, meninges and pituitary gland, and in several viscera (PubMed:9106168). Transiently expressed in the undifferentiated somites and the optic vesicles, and more persistently along the lateral walls of the intraembryonic coelom and around the hindgut diverticulum (PubMed:9106168)
+Expression increases during embryonic development and continued to steadily increase postnatally
+First expressed in the posterior epiblast of stage XIII blastoderm, then in the elongating primitive streak, early migrating mesoderm, Hensen node and in the notochord. In later stages, found in tail bud and entire notochord up to stage 26-28
+Expressed both maternally and zygotically. Expressed on the dorsal side during gastrulation. Becomes confined to the floor plate, notochord and dorsal endoderm during neurulation. Expressed in additional domains at the tailbud stage in cranial nerves, ear vesicle, dorsal fin and somites. Dorsal midline expression becomes restricted to the floor plate and hypochord
+Expressed during pollen development, peaking at the tricellular stage
+Expression is developmentally regulated being high and specific in a wide range of developing tissues including liver, kidney, brain and pancreas (at protein level)
+Expressed at 9.5 dpc in the ventral domain of the neural tube, with dorsal expression apparent at 10.5 dpc, as well as in the dorsal bud of the pancreas. Detected at 11.5 dpc within the ventricular zone of the neural tube in the hindbrain, diencephalon and telencephalon; also detected in the epithelial lining of the bronchi and esophagus. At 12.5 dpc, expressed in the bronchi, in the atrial and ventricular myocardium, the dorsal root ganglia and the epithelial lining of the rectum and bladder. At 15.5 dpc, detected in the developing choroid plexus epithelium, neural retina, olfactory epithelium and developing vomeronasal organ
+2-fold increase toward the end of the menstrual cycle
+Expressed during embryogenesis (PubMed:18385514, PubMed:20116245, PubMed:26506309). Transiently expressed during cytokinesis in embryos on the ingressing furrow and at the midbody during early abscission (PubMed:20116245). Expressed during the L4 stage and young adult stage of development (PubMed:22634595)
+Highly expressed during early stages of development at 17 dpc and postnatal day 10 (P10) but significantly reduced in the adult brain
+Present in dividing tissues during all stages of embryonic development
+Isoform 1 is present in constant amounts in vegetative cells and throughout development. Isoform 2 is barely detectable in vegetative and early preaggregative cells, but present at high levels during aggregation and in later stages (at protein level)
+Expressed during somatic and zygotic embryo development
+Expressed both maternally and zygotically. Expressed ubiquitously in the cleavage, blastula, gastrula and early somitogenesis stages. Expression declines during gastrulation. At 26 hours, expressed weakly throughout the head, and more strongly in the mesenchymal neural crest cells behind the eyes and in the endoderm and haemangiogenic region of the tail
+Expressed during development. Expression levels decrease steadily from the initiation of development until late culmination
+Expression increases greatly with the transition from secretory to maturation-stage ameloblasts, is maintained during the maturation stage and gradually declines towards the zone of reduced ameloblasts
+Weakly expressed in embryo compared to VRK1 and VRK3. Expressed from 10.5 dpc to 13.5 dpc in developing liver and then decreases. It increases again from 17.5 dpc and remains thereafter. Highly expressed in hematopoietic embryonic tissues from 10.5 dpc to 14.5 dpc. Strongly expressed in the yolk-sac
+Found in craniofacial tissues from embryonic day 42-53. Expressed in fetal skin 11 and 15 weeks after gestation
+Transiently expressed on a subset of axons in the developing rat nervous system
+Expressed in ripening fruits from the 20th day after anthesis and increase during the ripening (at protein level)
+Expressed from embryo to adult in the pharynx and intestine
+Expressed in the cardiac crescent and later in the myocardium in stages 4 to 25
+Expressed maternally. Expression peaks in the early stage II oocyte and levels are maintained throughout oogenesis
+Specifically expressed in anthers from early stage 9 to early stage 12 of flower development, with a peak during stages 9 to 11
+Detected only in seeds of 2-3 days after pollination (dap) siliques
+Expression is initiated during early development throughout the notochord and extinguished between 24 and 48 hours after fertilization (PubMed:17543297). At 24 hours after fertilization, expressed ubiquitously throughout the embryo (PubMed:25959397)
+Expressed in germinating seeds and then root seedlings up to 12 days after imbibition
+Expressed in high amounts from endometria of day 18-21 pregnant cows
+Strongly expressed between fetal day 17 and birth as well as at weaning and thereafter
+Expression increases in pro- and pre-B-I cells, decreases in large and small pre-B-II cells, and increases again in immature and mature B-cells
+Expressed in lodicules, stamens, carpels and ovules during their development
+Expressed during pollen germination and pollen tube growth
+Expressed in temporally and spatially restricted patterns during embryogenesis in the anterior, ventral and terminal regions of the embryo
+Expressed within 4 hours after induction and continued to accumulate over 24 hours
+Present in ovary, early embryos and throughout the development (at protein level). Deposed in the egg during oogenesis
+Expressed at the early to middle stages of seed maturation
+At 9.5 dpc and 10.5 dpc, abundantly expressed in the forelimb buds
+Expressed from early embryogenesis through to adulthood
+Expressed in the embryo, larva and adult with no difference in expression level across larval stages and adult
+Isoform II is expressed maternally and isoform I zygotically in larvae
+Expression in oocytes is very low. Barely detectable from stage 2 (2-cell stage) to stage 9. Increases strongly from stage 9 to 17, and decreases again at stage 25
+Detected at all stages (PubMed:14706351, PubMed:19104912). Expressed at low level in embryos compared to larvae (PubMed:14706351). Peaks in young adults (PubMed:14706351)
+Detected in developing kidney at 14 dpc, with levels increasing towards adulthood. Expressed during tooth development: at 12 dpc, detected in the thickening tooth epithelium, at 13.5 dpc in the lingual basal epithelium of the bud epithelium, at 14.5 dpc in lingual epithelium and between 18 dpc to postnatal day 1 in odontoblasts and stratum intermedium
+Highest levels in fruiting bodies, abundant in amoebae, moderately abundant in CL spherules but barely present in plasmodia and MCC spherules
+Expressed continuously throughout development
+In testis, poorly expressed during the winter stasis of the spermatogenesis rising during the breeding season and resumption period
+Very weak expression observed in the oocyte. Strongest expression seen in early tadpole (2 hours posthatching) and at 4/5 days posthatching
+Oocyte and early embryo
+Expression begins in early gastrula embryos, reaches a peak in late gastrula to early neurula embryos (stages 13-16) and then declines until stage 30
+Increased expression during seed development and as pollen development proceeded from uninucleate microspore to mature pollen
+Expression is detected from 7 dpc to 17 dpc, during fetal development
+Up-regulated during development of primary monocytes into macrophages
+Expressed in the ventral midline of the developing neural plate during neural tube closure
+Expression begins at the early-mid blastula stage. Levels are highest in the blastula and gastrula stages, after which levels decrease until the somite segregation stages. Expression persists to later developmental stages at a slightly higher extent than that of foxi1-A
+First detected after midblastula transition. Expression increases during gastrulation and neurulation. Expressed in the blastopore lip at gastrula stage (stage 11), the posterior mesoderm and anterior neural plate after involution (stage 14), the early forebrain and midbrain-hindbrain boundary at the neurula stage (stage 16), and the branchial arch region in tail bud stage embryos (stage 26)
+Expression starts at the neurula stage and persists during embryogenesis and larval stages until adulthood. At hatching and 5 days after hatching, present in XY embryos, but not in XX embryos. Detected only in the somatic cells surrounding germ cells in XY embryos
+Only expressed in adults. Expression varies in DDT resistant strains (Wisconsin, 91-R and Hikone-R)
+Expressed during somatic embryogenesis
+Faint expression in buds and flowers. Increases during the very early stages of seed development, reaches a maximum at the globular embryo stage and stays high throughout seed formation
+Highly expressed in fetal brain, with decreasing expression in postnatal stages
+Expressed maternally but largely absent later in embryonic development. Also expressed in adult
+Expressed during apoptosis of lymphoid and myeloid cells
+The level of protein does not vary in a circadian rhythm and is stable throughout day and night (at protein level)
+Expressed both zygotically and maternally. Expression is highest in early embryos and adult females
+Following inoculation with S.meliloti, accumulates strongly in the nodule primordia. In young nodules, expressed in a broad apical region and in the vasculature. In mature nodules, predominantly observed in the apical part of the nodule encompassing the pre-infection and infection zones (PubMed:20971894). Localized on infection threads before rhizobia are released (PubMed:25351493)
+At 10 dpc, expressed in the temporal aspect of the retina and the anterior portion of the alar midbrain. At 10.5 dpc this retinal pattern of expression persists, with expression also beginning in the lens. Also expressed in the spinal cord, the optic cup, the presumptive lens and the genital ridge. Expressed in the dorsal midline, somites, and interdigital tissues from 9.5 dpc to 13.5 dpc
+Expressed both maternally and zygotically in larvae, pupae, and the heads of adults
+Expression in testis is detected 16 days after birth and increases gradually to reach a plateau about 4 weeks after birth (at protein level)
+Accumulates progressively during fruit development
+Expressed at the 14 cell embryo stage
+Expressed constitutively during the life cycle
+Expressed during the parasite blood stage, specifically in schizonts (at protein level) (PubMed:2406433). Not expressed in free merozoites (at protein level) (PubMed:2406433)
+Widely expressed in embryos at 12.5 dpc
+Progressive decrease in roots from the leaf opened stage to the green fruit, red fruit and root growth stages, respectively
+Expressed in ookinetes from the maternal gene (at protein level) (PubMed:24471657). Expressed in both female and male gametocytes; expression is higher in male gametocytes (PubMed:21790945). Not expressed during the asexual blood stage (PubMed:21790945). Not expressed in oocysts (PubMed:24471657)
+Expressed at all developmental stages with levels declining as development proceeds
+Low levels at embryonic day 9.5, and then sharp increase since embryonic day 12. In the developing forebrain and cerebellar primordium, strictly expressed in postmitotic neurons
+Expressed from old embryos. Expressed in larvae and adults
+Expressed both maternally and zygotically throughout development. Zygotic expression levels rise after embryonic stage 9
+First appears in blastoderm embryos after onset of cellularisation
+Expressed in embryo at 16 dpc onwards
+Expressed during seed maturation. Expressed in the maturing seeds 24 days after flowering
+Expressed during the estrus cycle. Expressed during diestrus and proestrus with an eight fold decline when estrus cycle is reached
+Expressed during infection of the host
+Specifically expressed in sporogonic (macrogametes) stages of parasites
+Expression is kept at constant levels after the onset of development
+Detected at 10 dpc in developing brain, and expression is more prominent in the neuroepithelium compared to the surrounding tissue. At 12 dpc expression is enhanced throughout the CNS and is detected along the full length of the spinal chord. At 16 dpc expression remains enhanced in the CNS, and is particularly prominent in the olfactory bulb (PubMed:10995551). Also highly expressed in dorsal root ganglia (PubMed:10995551). At 18.5 dpc is prominently expressed in the marginal zone of the cortex, an area rich in neuronal and glial cell projections (at protein level) (PubMed:15572692). Detected at 16.5 dpc in ocular lens, specifically localized where the tips of migrating secondary fibers forms adherens junctions with anterior epithelial cells (at protein level) (PubMed:15572692)
+Transcribed in the stolon tip during the early stages of tuberization. Maximum expression was in non-swelling stolon tips from stage b, and level remained high as tuber increased in size
+First detected in the developing viscera at 30 hours. Expression is gone by 5 days
+In the embryo, highest levels occur between days 12 and 14 and decrease rapidly to much lower levels in the adult
+Expressed at all developmental stages from embryogenesis to adulthood
+Expressed throughout the egg-chamber development (at protein level). Expressed in the embryo
+During embryogenesis, highly expressed in the myotome compartment of the somites, and later in limb buds and axial skeletal muscles. Specifically expressed in skeletal muscle, and not in other muscle tissues or non-muscle tissues. Expression is down-regulated postnatally
+Expressed in the presmitic mesoderm, the somites, the developing peripheral nervous system and arterial smooth muscle. Expressed in atrioventricular cushions from 9.5 dpc to 12.5 dpc. Also expressed in developing retina
+Is abundantly expressed and accumulates in the walls of developing fruiting bodies (only in fruiting dikaryons)
+Specifically expressed in epimastigotes (at protein level)
+Induced during late exponential phase, and maximum expression is reached during the first hour of stationary phase, both under sporulation and non-sporulation conditions
+Expressed in fetal liver (at protein level). Expressed in embryonic hematopoiesis sites
+Expression is specific to the mesoderm of the gastrula
+Expressed both maternally and zygotically during oogenesis and early development
+Expressed in newborn and adult heart and brain tissues. Expression is not evident in prenatal days
+Expression starts at stage 20 in the somites. At stage 22 is also detected in the cement gland, and at stage 30 is expressed in the somites, pronephros, eye, cement gland, neural tube, and neural floor plate
+At 15.5 dpc, mid to low expression throughout the midbrain, with more prominent levels in the telencephalon, especially in the intermediate zone, the midbrain roof, the olfactory epithelium, the inferior colliculus, and the medulla oblongata. telencephalon revealed concentrated (at protein level)
+Detected in cochlea after 15 dpc. Detected in the spiral limbus in neoneates at 2, 8 and 10 days after birth, before the onset of hearing
+Expression increases during S phase, is maximal at the G2/M transition, and declines during M phase (at protein level)
+Expressed in all body-wall muscles in L3 stage larvae, and at a lower level in L4 stage larvae and adults
+Expressed in endosperm 21 days after pollination
+Highly expressed in the female germline. Degradation at the meiosis-mitosis transition reduces cytoplasmic microtubule severing activity, thereby allowing the formation of larger mitotic spindles
+Expressed maternally and zygotically (PubMed:23525007). During embryonic stages 12-13, becomes restricted to the salivary glands (PubMed:23525007)
+Restricted to the presumptive articular cartilage zone prior to joint cavitation and to the articular cartilage and fibrocartilaginous elements in the joint, spine and sternum during embryonic development. Detected from 9.5 dpc in the vasculature of the central nervous system. At 16.5 dpc, present in intervertebral disks of the spinal cord, lip epithelium and developing oral and tooth germ epithelia (at protein level)
+Detectable at 8-16 dpc. Lowest expression was seen at 8 dpc
+From 9.5 to 11.5 dpc, expressed in the branchial arches, otic vesicle, limb buds, somites, craniofacial mesenchyme and tail buds. At 14.5 dpc, expressed in the developing tongue, nasal cavity, palate, adrenal gland, in the forebrain, dorsal root ganglia and in the somites. At 14.5 dpc, also detected in lung, rib cartilage, kidney and intestine (at protein level)
+Expressed at 13.5 dpc in lung, liver, spleen, stomach, aorta, trachea, and perichondrium (PubMed:15733665). Expression increases during osteoclast differentiation (PubMed:27505886)
+Detected in 1-3 day old adults
+Expression begins in late embryo and end late third larval instar. Maximal expression is at the end of the first larval instar
+Mid to late gestation (gestation day 15)
+Highly expressed at restricted set of epithelial structures and highly concentrated at their junctional complex regions. At 6.5 dpc, localized at the most apical regions of cell-cell adhesion sites of the entire embryonic ectoderm; not detected in the extraembryonic regions. At 7.0 dpc, expressed in the primitive streak and the migrating paraxial mesoderm. At 7.5 dpc, highly expressed at the junctional complex regions in the primitive streak region (neuroepithelium) and the neural fold/grove region, but hardly detected in other areas of the ectoderm. By 8.5 dpc, highly expressed in the tail bud, somites and the paraxial mesoderm, concentrated at the junctional complex regions in neural tube, somites and pericardioperitoneal canal
+Higher expression at embryo stage 7.5 dpc than 11-17 dpc
+Expression is confined to the developing eye and skeleton. First level of expression are detectable around 15 dpc
+Gametogenesis. Synthesized from maternal transcripts but not from the zygote genome
+Expression starts early in spermiogenesis and finishes in the late spermatid phase
+It is initially expressed in the dorsal region of the embryo in a diffuse pattern at stage 17. Subsequently expression occurs in the early stages of development of the central nervous system, including the brain, spinal cord and eye. Later (stage 24) expression is found in the hindbrain, midbrain and forebrain and the somites. By stage 32, the expression is detected in the cranial neurons. Expression in the brain is increased, while expression in the spinal cord has decreased by stage 37
+Found in fetal liver and brain
+Expressed in gynoecium development, disappearing after pollination
+Expressed in the lungs from 23 weeks of gestation till birth
+Expression increases significantly between 6 and 12 hours, a period characterized by late gastrulation, early central nervous system development and early somite formation. Levels increase during later stages marked by rapid growth and development of the brain, and formation of rudimentary visual and auditory organs and myotomes (12 to 24 hours)
+Expressed constantly during multicellular development and is enriched in prestalk cells
+Induction occurs during the first 2 weeks after birth, being first observed in the epidermis of tail then the footpad and later in the ear
+First expressed at late blastula (stage 9) with expression peaking at early gastrula. Expression then disappears and does not return
+Expressed in early embryo
+Accumulates at about the time sterigmata appear and remains at high levels throughout the final stages of conidiophore formation and during spore differentiation and maturation
+Expressed at early stages of nodule development. Maximal expression is seen in nodules from 14-day-old plants after which levels decrease
+Expressed mainly in neurons belonging to a late migration wave. During adulthood, it persists at a high level in the granular layer of the cerebellum, the hippocampus and the olfactory bulb. In lung, detected at low levels at the pseudoglandular stage (14.5 dpc), with expression starting to increase at the beginning of distal lung development (16.5 dpc) and remaining at the same level during saccular development (18.5 dpc). The expression levels are highest at the beginning of and during alveolar development (P5-P14) before decreasing again to low levels at the end of alveolization (P30)
+Constitutively expressed with a slight increase during the tight mound stage (at protein level). Detected at very low levels in growing cells and aggregates up to the loose mound stage. Highly expressed in tipped aggregates and in the Mexican hat stage. Expressed at lower levels in early and late culminants and in fruiting bodies
+Expressed maternally. Prominent in the egg and during early cleavage stages. Expression decreases slightly between neurula and late tailbud stage before elevating again at the tadpole stages
+Highly expressed in cerebellum in 1 to 3 week old rats. Expression levels before and after are much lower. Expression in total brain increases slightly during development and remains at a constant high level after birth
+Expressed at low levels in the brain in early embryonic stages. Levels increase to a maximum before or just after birth, and are lower in adult brain (PubMed:1768439). At 16 dpc intensely expressed in the matrix of the developing cartilage and persists in the matrix of the mineralized cartilage at 20 dpc (at protein level). Localized within the unmineralized cartilage matrix (at mRNA level) (PubMed:9817766)
+Expressed in fetal tissues. More abundant in kidney
+Expression increases steadily throughout embryogenesis and decreases slightly in the adult
+Expressed at all developmental stages from embryogenesis to adulthood. Evenly expressed in most tissues during the L1 stage of larval development, however, expression is weak in the intestine and high in muscle
+Expression is enhanced in ripening fruit
+Highly expressed in dry mature seed and by the stages 2-5 of developing seed. The peptide IB-AMP1 is also detected at early stages of germination (24 hours and 48 hours postgermination)
+Present at low levels in developing ovules. Within mature female gametophytes, high levels in the central cell nucleus and weak levels in the egg cell nucleus. In fertilized ovules, expressed in the endosperm nuclei during 2 days after pollination
+Expressed in brain, lung, liver, and kidney
+Constitutively expressed in etiolated and green seedlings
+Expressed in early embryos
+Most abundant in the youngest flower buds, but levels decline as flowers mature. Specifically and transiently expressed in tapetal cells during microspore development in anthers (at protein level)
+In roots, restricted to the mature vasculature but absent from the meristem
+Expressed in the adult and in the embryo where it is detected at 12-18 dpc
+Transcript levels increase at the beginning of seed maturation and remain high until seed desiccation is completed. High levels early in seed imbibition, but decline as the seed germinates
+Expressed in the two-cell stage embryo (PubMed:22378640). At early globular embryo stage, expressed both in the basal region of embryo proper and suspensor cells (PubMed:22378640). At heart and torpedo embryo stages expressed in the basal region apical regions of the embryo proper (PubMed:22378640)
+Maximum levels in Th1 cells between day 3 and day 8 of activation
+Expressed at stage 4 in the ectoderm, at stage 6 in the anterior most neural plate, at stage 7 and 8 in the anterior neural fold and at stage 9-10 in the evaginating optic vesicles. At stage 14, highly expressed in developing retina and in infundibulum region
+First detected in stage X-XI blastoderms in the posterior epiblast. At stage 4, detected in the ectoderm around the primitive streak and in later stages, expressed exclusively within the mesoderm of the segmental plate. Expression continues here beyond trunk and tail bud formation and disappears by stage 26-28
+Observed restrictively in brain throughout embryonic (E) and postnatal stages (P). Expression pattern in brain slightly changes from 13 dpc to P21
+Expressed in adult ovaries and 0-3 hours embryos (at protein level)
+Expressed throughout larval development and adulthood
+Expressed during vegetative growth and all stages of development, with a peak during slug formation
+Expressed in preimplantation embryo. Expressed in liver at 16 dpc but not at 13 dpc
+Synthesized in the oocyte in early and late embryonic stages
+Expressed in 8 dpc intestinal precursor cells in developing embryos, and in intestine throughout development into adulthood
+Expressed during development; with a peak between 8-12 hours of development
+Expressed mostly in 5-day old seedlings, at developmental stage 1
+Expressed within a subset of cells in the subcapsular or developing definitive zone of the adrenal gland
+Increased gradually from days 8-12 and decrease to low levels by days 16
+Barely expressed in ripe fruits
+In the spinal cord region, expression is initially detected in the ventral white matter at 18.5 dpc, up-regulates rapidly afterward, and peaks at early postnatal stages from P4 to P7. At P15, expression starts to be detected in the gray matter of spinal cord but gradually disappears thereafter. Also observed in corpus callosum and the white matter of cerebellum at P15 stages
+Detected in hypoglossal cord and first branchial arch at 10.75 dpc (at protein level)
+Present at all times of development. No change of levels during senescence or pathogen attack
+Expressed during postnatal development from day 8 (PubMed:7857651). Highest expression around day 23 with moderate levels expressed to adulthood (PubMed:7857651)
+Differentially expressed during embryogenesis. First detected throughout the somites at 8.5 dpc and in the myotome at 11.5 dpc. Expression was observed in muscles ventral to the developing vertebral column of the neck, thorax, abdomen and tail. Expression was maintained in skeletal muscle types well after the terminal differentiation of muscle fibers. During cardiac development, expression was restricted to the myocytes of the primitive heart tube, and by 10.5 dpc, it was expressed in the muscles throughout all the cardiac chambers. At this last stage it is also detected in the hepatic primordia, and later in embryonic liver. By 15.5 expression was also observed in the smooth muscle surrounding the digestive, respiratory and urogenital tracts
+At 6.0-6.5 dpc, expressed throughout the egg cylinder with highest expression in the epiblast. At 9.5-10.5 dpc, expressed in the lateral sclerotome and in mesenchymal cells of the limb buds and body wall. At 11.0 dpc, expressed in a metameric pattern extending along the length of the embryo. By 11.5 dpc, expression in the developing vertebrae and invertebral disks is extended caudally. High expression was seen in precursors of the ribs and bones of the limbs. Expression in progenitors of the ribs and the axial and appendicular skeleton becomes down-regulated when ossification is initiated
+Transiently expressed during embryonic development of the nervous system, detected at 11.5 dpc and declining after 15.5 dpc
+Abundant only during the third larval stage
+Weakly expressed in metaphase II oocytes. Strongly up-regulated after fertilization at the pronuclear stage and restricted to the female pronucleus. Subsequently localized to the nucleus of each blastomere and on condensed chromosomes in mitotic cells
+Expressed throughout the third and fourth instar. At the beginning of the last (fifth) instar, the expression decreases rapidly and becomes undetectable by day 4 and until pupation
+Expressed in developing seeds at low levels from 5 to 20 days after flowering (DAF)
+Expression starts at 8.5 dpc and undergoes a second peak of activation at 12.5 dpc (PubMed:11707329). At 12.5 dpc, expression encompasses the entire central nervous system, with highest levels in the dorsal root and trigeminal ganglia (PubMed:11707329). Expressed in the granule neurons and Purkinje cells in the external and internal granular layers of the cerebellum from postnatal day 6 (PubMed:20878296)
+Expressed throughout all developmental stages (PubMed:19150446). In the third instar larva expressed in fat bodies, brain lobes, eye-antenna imaginal disks, wing imaginal disks, salivary glands and ovaries (PubMed:19150446)
+Expressed from 12 dpc to 16 dpc. Mice which are deficient in LRP8 have neuronal migration defect
+At 17.5 dpc, primarily detected in the spiral prominence and the Claudius cells and weakly in hair cells (at protein level). Also detected in the lumen surface of interdental cells in the proximity of Reissner's membrane and at the base of nascent tectorial membrane (at protein level). Similar expression pattern in P0 cochlea, with additional detection in some supporting cells (at protein level). At the same stage, in saccule, weakly expressed in hair cells and more prominently in the saccular roof (at protein level). By P6, expression becomes more restricted. Mainly detected in the outer hair cells, Deiter's cells and Claudius cells (at protein level). In the tectorial membrane, localized to the base. In the saccule, detected at high levels in the saccule roof with little change in the hair cells (at protein level)
+Expression is highest during early hyphal growth and dramatically reduced after mycelial expansion
+Detected in thalamus, but not in hippocampus and neocortex at 20 dpc. At birth barely detectable in hippocampus. Expression increases steeply from day 5 to day 9 and then stabilizes at adult levels
+Biphasic expression pattern with high expression in the L1 and L2 larval stages and gradual decrease through adult stages
+Expressed in ripening fruit, levels are highest at the harvest of fruit and decrease as the fruit ripens
+First observed in mature flower buds and accumulates transiently during 4 days after anthesis
+Before 8 dpc, expressed in the future rhombomere r3 at 0-3 somites, followed by expression in rhombomere r5 in 4-7 somites at 8 dpc, and maintained until 12 somites (PubMed:8093858). Expressed in migrating neural crest cells from r5/r6 (PubMed:8093858). Expressed in boundary cap cells that surround nerve exit points from the central nervous system at 10.5 dpc (PubMed:7935840, PubMed:8093858). Up to 14.5 dpc, expressed in motor and sensory roots of cranial and spinal nerves (PubMed:7935840). After 15.5 dpc, expressed in the entire peripheral nervous system (PubMed:7935840). Expressed in the embryonic nervous system (PubMed:17938205). Expressed in myelinating Schwann cells 2 weeks after birth (PubMed:7935840)
+In inflorescences, observed at the coleoptiles, paleas, lemmas, lodicules, anthers and stigmas
+Activity increases just before cells entry in the stationary phase
+Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly degraded at M/G1 transition
+Expressed throughout development. Expression is very low in vegetative cells and starts to accumulate in the first 2 hours after the initiation of development. It reaches a peak at 4 hours and then declines. However, a slightly larger transcript accumulates after 10 hours and remains until 22 hours of development
+Highly expressed in the developing nervous system
+Present in germ cells during early oogenesis, but not during late oogenesis
+Produced during vegetative growth and in encysting cells
+Not detected at 11.5 dpc. Specific signals are observed within seminiferous cords in male gonads at 12.5, 13.5, 14.5, and 16.5 dpc and in newborn testes. In 16.5 and newborn testes, its expression is also found in epididymis. No specific signal is found in female gonads
+Expression initiated at midgestation
+Found in the nucleus of germinal-vesicle (GV) stage oocytes prior to fertilization. Accumulates in the male and female pronucleus after fertilization. Expressed in the nuclei of all blastomeres from the two cell stage to the compacted morula stage, although absent from the polar body and inner cell mass (ICM). Found in the nuclei of polar and mural trophectoderm cells from 3.5 dpc, and at high levels in the epiblast from 5.5 dpc to 7.5 dpc. Expressed by primitive germ cells (PGCs) in both male and female from 9.5 dpc to 13.5 dpc, at which point expression declines. A low level is observed in Sertoli cells of the testis at 17.5 dpc
+Expression coincides with the onset of programmed cell death (PCD) at all stages of embryonic development
+Expressed in conidia (PubMed:27058347, PubMed:24340081)
+Expressed zygotically. First detected at the mid-blastula transition. Confined to the future ectoderm by the shield stage, and to the presumptive neuroectoderm by the 75-80% epiboly stage. From the tail bud to the 3-somite stage, expressed throughout the neural plate, except in the anterior margin; strongest expression in the presumptive ventral diencephalon. At the 12- to 25-somite stage, expressed broadly in the central nervous system. From 24-30 hours post-fertilization, restricted to the ventral diencephalon, midbrain and hindbrain/anterior spinal cord region, and to the retina and lens
+Expressed in the intestine and in head and tail neurons including CAN neuron at L1 stage larva. Expressed in the postdeirid neuron, in the developing vulva and in rectal epithelial cells at L2 stage larva. Expressed in lateral hypodermal (seam) cells and the hypodermal syncytium (hyp7) at L3 stage larva
+Expressed in the cytophore, spermatocytes and young spermatids during spermatogenesis. Not expressed in mature sperm
+Expressed in the embryonic anterior central nervous system. In the forebrain, and then in the eye and hindbrain
+mRNA already detected at 9.5 dpc
+Expressed constantly throughout the circadian cycle
+Developmentally regulated. Expression is high 3 to 5 days after germination and returns to basal level by day 9
+Shows relatively constant expression in both proliferating myoblasts and in differentiated myotubes, when assayed in C2C12 cell line (at protein level)
+Present in pollen cells and in all tissues of young seedlings (PubMed:17158605). In flowers, mainly expressed in petals, filaments, and pollen cells inside anthers (PubMed:17158605). In leaves, mostly observed in mesophyll cells and in cells surrounding the vascular tissue and lower epidermis, and, to a lesser extent, in the upper epidermis (PubMed:17158605)
+Detected in developing macrophages at 28 hours post-fertilization (PubMed:20424185). Continues to be expressed in macrophages at 2 and 6 days post-fertilization (dpf) (PubMed:25573892). Also detected in neutrophils at 2 and 6 dpf (PubMed:25573892)
+Expressed both maternally and zygotically in pupae at a low level
+Expressed in neurons from 260 minutes of embryogenesis, comma stage and into adulthood (at protein level) (PubMed:10207148). Expressed in late stage (3 and a half-fold) embryos in at least 20 pairs of neurons of the head, including the AVA, AVD and AVE interneurons, ASH sensory neurons, and RMD and SMB motor neurons (PubMed:10207148). Expressed at high levels in the AIN, AVH, AVJ, AVK, RIV, SAA and SIB interneurons (PubMed:10207148). At larval L2 stage, expressed in the tail in the PVT neuron (PubMed:10207148)
+Present at very low levels during early stages of development. Levels increase during late aggregation stage, reach a maximum and remain high during culmination and maturation of the fruiting body. Detected in upper and lower cup structures in late culminants and mature fruiting bodies (at protein level). First detected after 12 hours of development. Highly expressed at 12 to 16 hours of development. Levels return to basal levels during maturation of the fruiting body
+Expressed at all developmental stages, including in embryos, instar stages and pupae
+Expressed in Kupffer's vesicle at 12 hours post fertilization (hpf). Expressed in brain, neural tube, pronephric ducts, olfactory placode and the eye at 28 hpf. Expressed in ciliated cells of the olfactory placode, ear, neuromasts and pronephric ducts at 48 hpf. Expressed in neuromasts, olfactory sensory neurons and in the ear at 96 hpf (at protein level)
+Expressed maternally and zygotically throughout development to adults (male and female)
+There is a marked sex difference (female >> male) in the expressed level of mRNA for this protein
+Expressed weakly in the stage 10/10.5 embryo. Expression then resumes after stage 25
+Expressed during early development. Expressed in the epithelium of the embryonic gut tube (at protein level)
+Detected at 7 weeks of development in the forebrain floorplate of the CNS. Expressed within the mantle layer and migrating neuroblasts of the telencephalon at 12.5 weeks of development
+Strongly expressed at the mesencephalon (midbrain) of 12.5 dpc embryos
+During differentiation of the hair, it is one of the last keratins expressed
+Expression increases from 3 weeks to 6 months (PubMed:29025071). In mouse testis, mainly localized in the cytoplasm of round spermatids and elongated spermatids. In the cap phase, remains close to the acrosomes but begins to migrate to other regions around the nuclei. As spermiogenesis progresses, further separates from the acrosomes. In the acrosome phase, while the acrosomes formed hook-like structures and move toward one end of the nuclei, GARIN2 moveS to the opposite end. In the maturation phase, moves to the end opposite to the acrosomes and, at the end of spermiogenesis, is removed to the residue body together with most of the other cytosolic components. Finally, in caudal sperm, is retained in sperm flagella. In mature sperm, GARIN2 localizes in the midpiece of flagella (PubMed:29025071)
+Expressed at low levels in embryos
+Increased after 3 weeks of postnatal development
+Expression is confined to regions of the developing nervous system and pancreas. At 13 dpc expressed at lower levels in the trigeminal ganglion, the ganglionic eminence, the ventral neural tube, and dorsal root ganglia. Expressed at moderate levels in the tectum of the embryonic midbrain. Most prominent expression is in the diencephalon, where it flanks either side of the roof of the third ventricle, dorsal/caudal to the dorsal thalamus. Detected in the pancreas during the time when most of the pancreatic endocrine cell types are beginning to differentiate and endocrine precursor cells remain loosely associated with the duct epithelium until they begin to form aggregates late in development
+Detected in embryos (at protein level) (PubMed:27016737, Ref.11). Expressed at all stages of development (PubMed:11438676)
+Expressed in the apical region (growing zone) of the root hair. Expressed in the basal growing zone of air-grown internode. Expressed in the growing region of leaves. Expressed in the developing seeds
+Expressed transiently during development of the brain and spinal cord, especially in the roof plate and the dorsal lip of the dermomyotome. Also present at the dorsolateral basement membrane of the spinal cord (at protein level)
+Increasingly expressed from early aggregation
+Expressed in cells of the ABa lineage at the 24-cell stage of embryogenesis
+Expressed in the lens fiber cells during embryogenesis. During somitogenesis expressed in somitic cells (at protein level)
+Detected only after some degree of neuronal differentiation has taken place and persists at least up to the newly hatched stage
+Accumulates to high levels in intestinal crypt epithelium during postnatal development
+It is expressed in neuronal and neuroepithelial cells during development of the CNS and PNS
+Found at low levels in vegetative cells and at higher levels during aggregation and mound formation (4 and 8 hours of development)
+Detected in the testis from the postpubertal stage (23 days) onwards, with highest expression at 29 days
+Constant expression level found in 3-12 week old leaves. Expression levels decrease during the light period, then increase again during dark. After wounding, expression levels decrease
+Expressed in cell cycle-dependent manner. Most abundant at the G2 and G2/M transition. Lowest expression in S and M phases
+Little or no embryonic expression
+Isoform 2 is expressed both maternally and zygotically, and is the major isoform in adults. Isoform 1 and isoform 3 are expressed zygotically. Maximal expression is after 1 to 2 days of development and becomes down-regulated as cells differentiate
+Expression increases during promyelocyte differentiation
+Expressed throughout B-cell differentiation, with highest expression in immature bone marrow B-cells
+Detected in the developing testis at postnatal day 20, with increasing levels through development
+Expressed during early steps of seed germination
+In diapause eggs, expressed after chilling at 5 degrees Celsius for 5-6 days, persists for 30 days and then decreases
+Highly enhanced expression in developing cotton fibers, with maximal expression occurring at the time of transition between primary and secondary wall synthesis
+Activity is highest in chloroplasts isolated from young, actively dividing leaves (at protein level)
+First detected at postnatal day (PND) 8, its level increased dramatically from PND 16 to 42 (at protein level)
+Poorly expressed in the testis 15 days after birth. Levels increase sharply between days 15 and 30 reaching a maximum by day 45 and the onset of spermatogenesis
+Found in both the 10-day embryonic brain and body tissues. In the embryonic brain, expressed in the developing cortex of the telencephalon and major cortical tracts. Also expressed in the hippocampus, fornix and striatal cells and tracts. In the diencephalon, strongly expressed in thalamus, hypothalamus and thalamo-cortical projection. Also expressed in red nuclei of the mesencephalon and in the cerebellum. In the spinal cord, persistent expression occurs in the dorsal funiculus and ventral gray matter. In myogenic progenitor cells, highly expressed at 11.5 dpc and ceases its expression at the late fetal stage (17.5 dpc) (PubMed:27446912)
+Expressed from early embryonic stages through to adulthood
+Expression is first detected in the embryo during gastrulation
+Expressed at very low levels in myotubes and early postnatal muscle. Expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood
+Expressed both maternally and zygotically. Expressed at relatively constant levels throughout development
+Highly expressed between the sixth larval instar (La6) and day 4 prepupa (Cr4), coinciding with a phase of rapid wing disk morphogenesis. Expression drops to a low level by day 6 prepupa (Cr6)
+At 4 days post fertilization (dpf), it is widely expressed in the brain and eyes. There are high levels of expression in the retinal ganglion layer, the inner nuclear layer, the photoreceptor layer, the ciliary marginal zone, jaw mesenchyme, oral epithelia, and pectoral fins
+Expression restricted to early to mid-stage of silique development
+Weakly expressed in 7, 11 and 17 day embryos. Expressed at a higher level in 15 day embryos
+Expressed in young seedlings and progressively confined in the elongation zone of the root during seedlings growth
+Expressed in the meristem during gametogenesis and mainly in ovule, stigma, anther/pollen and vascular tissues during flower development. In flower buds, present in petal primordium and apical meristem. Later expressed in stamen primordium and pistil meristem after petal formation. Accumulates in stamen, pistil and vascular tissues of the bud base. Highly expressed in sporogenous cells in anther, pistil stigma, ovules, pollen grains, anther walls, and basal vascular bundle. In anthers, first present at high levels, then declines rapidly from stage 13 (when microspores transform into vacuolated pollen grains after mitotic divisions) to stage 16 (when the sepals are better separated, and the faint yellow petals are clearer) to a very low level (PubMed:29632966). In fruits, expressed at high levels at the immature stage and then declined continually through all stages of fruit development (PubMed:22345638, PubMed:22108525, PubMed:25039074)
+Expressed early after seed germination, when the radical has just emerged from the seed coat
+Barely detectable in dark-grown seedlings. Induced after 2 hours of light exposure
+Expressed during postnatal days P3 to P60, with decreased expression after postnatal day 14
+Expressed in post-ecdysial nymphs
+Expressed in ovary and testis at 15.5 dpc
+Differentially expressed in embryonic and adult tissues. Its abundance decreases from 10 dpc to birth. At 10.5 dpc, detected in the atrial septum and endocardial cushions, and at lower levels in the atrial and ventricular endocardium. Strong expression detected in embryonic and postnatal retina. At P0 and P3, expression detected in the outer neuroblastic layer. After P7, the expression becomes more restricted and is observed in the middle to outer part of inner nuclear layer, and is not detectable at P21 when retinal development is almost complete
+Specific to both elongating procambial cells and to cells isodiametric in size that are presumably destined to develop into higher-order veins. Strongly expressed in advance of perceptible procambium formation. Expressed in the cells of prospective veins in leaf primordia of seedlings and cotyledons of developing embryos, and the vascular tissue of developing flower buds
+Detected in embryos from 7.5 to 17.5 dpc (PubMed:9737970, PubMed:14505572). Detected in the epiblast at 7.5 dpc, in the cardiac region and tail bud at 8.5 dpc, in otic vesicle and branchial arches at 9.5 dpc, and in forebrain, branchial arches and limb buds at 10.5 dpc (PubMed:14505572)
+The ratio of the two isoforms changes during development; isoform 1 is more abundant than isoform 2 in earlier embryonic stages, whereas isoform 2 is predominant in the adult stage. Expressed in the ventricular zone and in neurons of the developing cortical plate (at protein level). Expressed in migrating neurons of the external granule cell layer at 13.5 dpc while expression appears in the Purkinje cell layer at 17.5 dpc (at protein level). Expressed postnatally in Purkinje cells and hippocampus (at protein level)
+Isoform 3 is expressed in brain, heart, lung, liver and kidney at 15.5 dpc. Isoform 3 is expressed in heart, lung, liver and kidney at 18.5 dpc
+Expression in the endometrial epithelium fluctuates during the menstrual cycle, being greater during the secretory phase when compared with the proliferative phase
+At 18 dpc, expressed in kidney, adrenal gland, heart, stomach, muscle and eye, but not in lung and skin
+Expressed following gastrulation. At the 1-somite stage, expressed in the paraxial mesoderm. Subsequently expressed in the telencephalon, the otic vesicles, the somites and the anterior presomitic mesoderm
+In the embryo, levels are highest at day 7, decrease by mid-embryogenesis at day 11 and increase again in late embryogenesis at day 17
+Accumulates in the testis starting at postnatal day 3, and remains at a steady level from 1 to 3 weeks in age
+Highest expression observed in the embryo. Levels decrease dramatically after embryogenesis, remain relatively constant during larval stages and increase again at the onset of adulthood
+Levels are high at cleavage and blastula stage, and low at gastrulation stage. Subsequently, levels increase from mid-neurulation to the tail bud stage. Detected in embryonic brain at the tail bud stage
+Localized to cotyledons and hypocotyl in the early stages of development, and later appears in young leaves
+In liver, expression gradually increases up to 8 weeks of age
+Expressed by developing CNS stem cells. When cortical stem cells differentiate into neurons, astrocytes, and oligodendrocytes, expression level is reduced in both dividing and postmitotic progeny
+Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development
+Detected in the Golgi apparatus of pachytene spermatocytes beginning at stage VII and extending up to stage XIV. Detected in the Golgi apparatus of spermatids at steps 1-15 of spermatogenesis
+First detected in bone marrow promyelocytes. Expression increases throughout myelocyte differentiation and peaks in the mature myelomonocytic cells
+Expressed in ectodermal cells of the yolk sac during epiboly on days 0 - 5 (PubMed:16003522). Expressed in ectodermal cells of the albumen sac on days 8 - 13 (PubMed:16003522)
+Expressed both maternally and zygotically. Present at the gastrulation and post-segmentation stages
+Expressed in prechordal plate between stages 3 and 15
+Predominantly expressed at early embryonic stages and later in L4 and adult stages
+Expressed at low levels in lacrimal gland of both immature females and males at 10 days of age (at protein level) (PubMed:18703064). At 15 days of age, higher levels are found in males than females (at protein level) (PubMed:18703064). Levels decrease in males after day 20 and there is no expression in males by day 36 (at protein level) (PubMed:18703064). Highly expressed in lactating females when estrogen levels are low (PubMed:15950295, PubMed:9634868, PubMed:10622403). Levels drop by 25 days post-weaning (PubMed:10622403)
+Expression varies approximately 30-fold during the estrous cycle, with lowest levels during diestrus and highest at estrus. During pregnancy, uterine expression is dramatically reduced at 1.5 dpc and reaches its lowest levels at 4.5 dpc, coincident with the time of embryo implantation
+Expressed during the asexual blood stage; expression is low at the ring stage, increases in trophozoites and early schizonts and sharply decreases in late schizonts (at protein level) (PubMed:12413950, PubMed:12464414, PubMed:26251451). Expressed during the sexual blood stage (PubMed:12464414)
+Expressed in highly specific patterns within the developing embryo
+Detected in trophozoite and schizont stages (at protein level)
+Confined to proliferating cells. Mainly present in proliferating tissues (e.g. root, shoot and floral meristems, and young organs) and vasculature. During petal growth, gradually restricted to the distal part of the petal. Expressed in developing embryos
+Expressed both maternally and zygotically. Present in oocytes and in early embryos until shortly after gastrulation, after which levels decline and remain low through tadpole development
+Selectively expressed in third trimester placenta
+Expressed at a low level during the asexual cell-cycle within the host erythrocytes. Also expressed in gametocytes and in stages during development in the mosquito
+Present in fruit throughout the development and ripening
+Detected in the testis at low levels at postnatal day 5 but increases at postnatal days 20 and 45 (at protein level)
+Present in the vasculature and in multiple epithelial populations at 10.5 dpc. Present in the cell junctions of the retinal pigmented epithelium at 15.5 dpc (at protein level)
+Expression was first detected at 7.5 dpc in the cardiac crescent. Expression was observed in the myocardial layer but not in the endocardium. Expression was homogeneous in all heart segments with the exception of the outflow tract. Between 9.5 dpc and 10.5 dpc expression was also observed in the trabeculated areas. In more advanced stages of myocardial differentiation, expression in the ventricle was largely restricted to the compact layer
+Up-regulated by thyroid hormone in tadpoles during tail resorption
+Highly expressed in diapause embryos, in which cells were in a quiescent state (at protein level)
+Expressed during pachytene in testis: accumulates in early pachytene cells (stages I-VII), declines in late pachytene cells (stages VIII-X) and disappears in diplotene cells (stage XI) (at protein level). Expressed from spermatogonia to spermatids, with trace expression in mature spermatozoa and somatic Sertoli cells
+During embryonic development, highly expressed at 8 hours post-fertilization (hpf) (PubMed:28402832). Expressed at the pharyngula stage at 24 hpf and expression is maintained for 7 days post-fertilization (PubMed:29791492, PubMed:28402832, PubMed:30076291). During this time, expressed in the pharyngeal arches, and in the epidermis and proctoderm at 48 hpf, and in the epidermis at 72 hpf (PubMed:29791492, PubMed:12464617, PubMed:30076291). Also expressed in the mouth at 48 and 72 hpf (PubMed:12464617, PubMed:30076291)
+Expressed throughout development. During germination, initially restricted to the hypocotyl, but expression gradually shifts to the root and on day 6, to the vasculature of the cotyledons and then of the leaves. Increased expression in the shoot apex during the transition to flowering. Induced in the inflorescence vasculature and young flower buds as flowering commenced. Expressed in developing embryos from the early heart stage until torpedo stage
+Ubiquitously expressed in males and females throughout embryogenesis (PubMed:11156988, PubMed:27919077). Expression levels decrease from gastrulation toward late embryogenesis (PubMed:11156988). Enriched in the neuroectoderm at later stages (PubMed:27919077)
+Expressed zygotically by embryonic stage 11 (mid-gastrula)
+Expressed in developing endothelial cells and smooth muscle cells, as well as in surrounding mesenchyme, during embryogenesis. Up-regulated during myogenesis
+Expressed from late embryogenesis with expression continuing in larva, pupa and adult (at protein level)
+First detected in 20-day-old animals. Reaches a peak at 30 days
+Highest levels of ardD mRNA in spherules, less in plasmodia
+Expression increases quickly after induction of adipocyte differentiation, reaches a maximum after 3 hours and decreases by 12 hours. Expressed from embryonic day 10.5 dpc in heart and hindbrain, followed by an increased expression at 12.5 dpc that also involves a subset of cells on the luminal side of the left ventricular wall in the case of the heart and neuroepithelium in the case of the brain. At 14.5 dpc, expression is present in developing bones (proximal ribs, lower jaw and clavicle), but the expression in the heart is no longer detectable. At stages 16.5 dpc and 18.5 dpc, strong expression is seen in the long bones of the limbs, particularly in the growth plates, as well as in the facial and cranial bones and the primordial incisor. Expression in the ribs is seen in the proximal regions in those areas where the transition from cartilage to bone is expected to occur. Expression in the eye at 16.5 dpc is highly specific for the ganglion cell layer
+In roots, observed in root tips and elongating regions of the primary and lateral roots, especially in root hairs and collet hairs (PubMed:28138059). In reproductive organs, present in fruits and anthers (mostly in young anthers) (PubMed:28138059). Later detected in the pericarps and receptacles during maturation of siliques (PubMed:28138059). In siliques, expressed in the embryo (from the initial globular to mature stages), funiculus and seed coat (in the transparent inner integument) (PubMed:28138059). Expression levels are coordinated with root hair cell elongation (PubMed:28837399)
+Enriched in embryos, where it localizes predominantly to cortical regions and the cytokinetic furrow in telophase
+Expressed both maternally and zygotically (PubMed:2120044, PubMed:8405984). High levels of expression when mitosis is elevated; highest levels of expression are in early embryos with levels decreasing during embryogenesis and remaining low throughout most of larval development, and expression levels are also increased in unfertilized eggs and adult females (PubMed:2120044)
+Expressed both maternally and zygotically during all developmental stages
+Expressed in fetal kidney
+Expressed during the blood stage of the parasite
+Accumulates in tissues undergoing senescence
+During brain development, its expression is similar to that of synaptic markers. Expression is first detectable late in embryogenesis (14 dpc) and increases to reach a plateau about 20 days after birth, when most synapses have been formed (at protein level)
+Expressed in the early neural plate of embryos. Expressed in the hypoblast and Koller's sickle at pre-primitive streak stages. At stage 4, expression is detected in the node, the lips of the streak and the epiblast in the middle of the area pellucida. By the start of neurulation, expression becomes progressively concentrated in the neural plate, neural tube and sensory placodes including lens, otic and olfactory placodes. Expressed in the notochord and the sensory placodes at stage 16. Expressed in somites and persists in the myotome at later stages
+Not expressed in stage 1 flower. In stage 2 and 3 flowers, expressed in the central area of the floral dome, but not in the sepal anlagen. In stage 5 flower, restricted to the carpel anlagen. Stage 6, 7 and 8 flowers, expressed in the medial ridge. In stage 9 flower, expressed in the septum, style, and stigma. Shortly before anthesis expressed in the stigma and septum
+Expressed in larvae and adults
+Expressed in hypocotyls and petioles of cotyledons in 1- to 3-day-old seedlings
+Before the first zygotic nuclear division, seen in membrane structures confined in the embryonic cortex. This cortical distribution is maintained through stage 6. In cycles 10 and 11, the presence in the Golgi membranes between hexagonally arranged nuclei is readily observed in tangential optical sections through the embryonic surface. In stage 14, present in a thin vitelloplasmic layer below the plane that represents the basal borders of the cells separating the cellularized cortex from the rest of the embryo, and also within cells. Within the cells, appear to be more abundant in the cytoplasmic region between the nucleus and the embryonic surface. In early embryos, a large proportion appears randomly diffused, but in the later stages of embryogenesis, a larger proportion is associated with the membranes. In early embryos, expressed in the ovary. During embryogenesis, up-regulated in regions 2 and 3 of the germarium in meiotic cysts and in follicle cells. Expressed in testis tip starting in early meiotic spermatocytes. Also detected in paragonia. During embryogenesis, appears to be expressed ubiquitously at low levels and markedly up-regulated in the cells of the presumptive proventriculus and the salivary glands starting at stage 10
+Expressed exclusively in retinal ganglion cells during and after axogenesis
+Expression decreased during development, but persists in the adult brain
+Specifically expressed in the postnatal nervous system, reaching a maximum level at 3 weeks postnatal
+Complete loss of expression when naive B-cells proliferates and differentiates into Ig-producing plasma cells under in vitro stimulation
+Detected at 10 dpc in the intersomitic vessels, dorsal aorta and brain vasculature. In retina, strongly expressed in the developing retinal vasculature at postnatal day 4 and down-regulated in preformed vessels at postnatal day 8. Predominantly detected in capillaries and veins, and particularly at the advancing vascular fronts, as compared to arteries
+Present in developing flowers
+First detected in the ventral mesodermal cells just above the yolk plug at late gastrula. At the neurula stage, strongly expressed in the cement gland, dorsal root ganglia and otic vesicle region. At the tailbud stage, a strong expression is observed in the dorsal part of the optic cup and trigeminal ganglia, and it is also expressed in the branchial arches, heart anlage, nasal pit, proctodeum and the region around the pronephros
+Expressed in the lens placode at stage 14. Expressed at stage 18 when the invaginating lens placode closes to form the lens vesicle
+Expression in sciatic nerve is low in neonates, culminates seven days after birth and decreases rapidly thereafter (at protein level) (PubMed:22729949). Strong expression is detected at E.7 and drops at 11 dpc
+This protein seems to be found in both adult and newborn B.jararaca venoms
+At 16 dpc, widely expressed with high expression levels in hippocampus and low levels in heart. In the spinal cord, expressed as early as 12 dpc until p21, the expression levels decrease in the adulthood (at protein level)
+Not detected prior to birth, low levels of expression detected from postnatal days 1 to 7. Expression reaches adult levels by postnatal day 21
+Expressed during the asexual blood stage, including rings and trophozoites (at protein level)
+First detected at 14 hours post-fertilization (hpf) in the head and tail regions. Found mostly in the head region. Also detectable in the jaw of the embryo at 3 dpf
+Expressed in the yolk sac
+Expression is increased in differentiating erythroid cells (at protein level) (PubMed:26816381). Up-regulated during adipocyte differentiation (PubMed:14701838)
+Is expressed more abundantly in adult than in juvenile vipers
+Major expression is seen in the ovaries while moderate levels of expression are observed during embryogenesis and throughout subsequent stages of fly development
+Weakly expressed 2 days before birth, but gradually increased during the first 3 weeks of age, reaching a plateau around day 22 in both kidney and liver. At 45 days of age, renal and hepatic levels is 4 to 6 times higher than the level immediately after birth
+High levels of expression in eggs and first instar larvae (at protein level) (PubMed:16439308). Levels decline between the second and third instar stages, and then increase during the pupal to adult stages (at protein level) (PubMed:16439308). Expressed in the pupal and larval wing (PubMed:20036230). In pupal wings, expression appears to be enhanced in the presumptive longitudinal veins (PubMed:20036230)
+Expressed during development. Low expression starts at 8 hours development, and increases sharply in fruiting bodies
+Highly expressed in the scent-producing corollas and tubes of two days old flowers, reaching a maximum at day three post-anthesis, and, to a lower extent, in other floral tissues (e.g. ovary, pistil, sepals and stamen)
+In 9.5-12.5 dpc embryos, expression throughout limb bud mesenchyme. This expression overlaps with that of CYP26B1. Also strongly expressed in the caudal and craniofacial regions
+Expressed both maternally and zygotically (Ref.1). Expressed in the germ ring at the blastoderm margin during the shield stage of gastrulation, expression is higher dorsally than ventrally (PubMed:22406073). Expressed at the posterior dorsal midline at the four-somite stage and in the pectoral fin bud 48 hours post-fertilization (PubMed:22406073). Zygotic expression begins during somitogenesis and is confined to the mesenchyme of the developing tailbud, the posterior 4-5 somites and the ventrolateral mesenchyme of the head (Ref.1). In later stages, expressed in the pharyngeal arch mesenchyme and pectoral finbuds (Ref.1). Not detected in mature chondrocytes (Ref.1)
+Maternally expressed. Ubiquitously expressed throughout development
+In roots, predominantly expressed in the vascular tissue (PubMed:33316467). In the elongation zone and root hair region, also detected in root hairs and epidermis (PubMed:33316467)
+Levels of the proform increase in serum and placenta during pregnancy
+Not expressed until the onset of senescence in leaves
+Isoform 3 is only expressed in growth-arrested cells
+Found predominantly during early stages of spore germination
+Expressed in the meristem during gametogenesis and mainly in ovule, stigma, anther/pollen and vascular tissues during flower development. In flower buds, present in petal primordium and apical meristem. Later expressed in stamen primordium and pistil meristem after petal formation. Accumulates in stamen, pistil and vascular tissues of the bud base. Highly expressed in sporogenous cells in anther, pistil stigma, ovules, pollen grains, anther walls, and basal vascular bundle. In anthers, first present at low levels, then increases rapidly to reach a peak at stages 13-14 (when microspores transform into vacuolated pollen grains after mitotic divisions) before declines gradually (PubMed:29632966). In fruits, levels decline from the immature stage to the mature green stage and then rapidly increase to a peak at the turning stage (PubMed:22345638, PubMed:22108525, PubMed:25039074). Highly expressed in fruits at the onset of ripening when the abscisic-acid (ABA) content becomes high (PubMed:19246595, PubMed:22345638, PubMed:22108525). Progressive level reduction in ovaries (e.g. ovules, placenta and pericarp) after pollination (PubMed:19322584)
+In testis, detected in condensing spermatids but not at earlier stages of spermatogenesis (PubMed:11063263). In embryonic stem cells, expressed in undifferentiated cells and down-regulated upon differentiation (PubMed:24161396)
+Expressed during embryonic stage 11
+Present in animal blastomeres at 4-cell and stage 6.5. At stages 8.5 and 9.5 (blastula), detected broadly in the animal region. At stage 10 (early gastrula), remains broadly expressed animally, but also detected in the dorsal marginal zone (the Organizer), with lower expression in the ventral marginal zone. At stage 11, found in the forming neural plate in a noticeable antero-posterior (AP) gradient (anterior high and posterior low), with additional weaker expression in the head mesoderm. Remains detectable, but becomes faint in the neural plate at stage 13. By stage 15, detected at the anterior border of the neural plate and in ventro-lateral epidermis excluding the neural plate. Later, it is detected in the cement gland (an anterior organ) at tail bud stages (stage 25), in branchial arches, the otic vesicle, and developing pronephros, with diffused expression in the head (stage 35)
+Maternally expressed. Levels decrease during gastrulation and are then increasingly up-regulated during neurulation and tailbud stages. Weak ubiquitous expression is detected at all stages of development
+Expressed in the cartilage of ribs and limbs, in the eyes and spinal cord at 15 dpc (at protein level). Expressed in the lens epithelium at 13 and 16 dpc; not detected in the fiber cells of the lens. In the eyes, confined in the equator of the lens; not detected in the retina at 15 dpc. In spinal cord, expressed in the ventral part of the dorsal horn and the ventral horn at 15 dpc. Predominantly expressed in postmitotic cells
+Expression is low at stage XII of tadpole development, greatly increases by stage XIX, decreases thereafter and is relatively low by stage XXIV, when metamorphosis is almost complete
+Expressed at the morula stage (at protein level) (PubMed:29262349). Expressed in extravillous trophoblast and cytotrophoblast (PubMed:26460007, PubMed:16210391, PubMed:7589701). Expressed in fetal eye and thymus (PubMed:2336406)
+During the larval stage of development, expressed in uterine muscle progenitors and their descendants in the sex myoblast lineage, but only expressed in type 2 vulval muscle precursor cells of the vulval muscle lineage (PubMed:11799068). In larvae, it is also expressed in a subset of enteric muscle cells including the left and right intestinal muscles and the anal depressor muscle (PubMed:11799068, PubMed:21852953)
+Expression increases progressively from 7 dpc and is detectable in virgin mammary glands, then shows little if any change during pregnancy and declines to barely detectable levels after 3 days of lactation. Detected from 13.5 dpc in conjunctiva epithelium. In cornea, a weak signal is detected at 16.5 dpc and persists throughout the later stages of development
+In young plants, detected at a low level only in the root tips and lateral root primordia. In fully open flowers, primarily observed in the filaments and anthers
+Expressed during late development in the aleurone and embryo
+First detected in the presumptive limb field. As the limb develops from a limb bud into a cone, a stron homogeneous signal is evident. Strong expression persists as the cone flattens into a palette and digits begin to appear and is down-regulated as limb development advances. At the three digit stage there is a faint mesenchymal expression which disappears at the appearance of the fourth digit
+Expressed throughout the cell cycle. Expressed in actively dividing cells: root and shoot apical meristems, leaf primordia and emerging lateral root meristem. Expressed in light-grown seedlings from 1 up to 7 days after germination with a peak at 2 and 3 days
+Expressed in active growth stages of the segmentation wall and during early endospore differentiation
+Accumulates early during embryogenesis, but repressed late in seed development
+Expressed during ripening
+Specifically expressed in neuronal cells during development. First detectable at 9.5 dpc in prosencephalon. At 16.5 dpc, expressed in all brain areas, spinal cord and spinal ganglia. Within the brain, highest expression is found in maturing zones where neurons differentiate and lowest expression is found in ventricular zones where proliferation takes place. Brain expression remains high at later embryonic stages and during postnatal brain development
+In the embryo, barely detectable at day 17, peaks at day 11 and remains constant thereafter. Detected early during embryogenesis in ectodermal, endodermal, mesodermal and extraembryonic tissues. Expressed in the developing central nervous system. In the developing central nervous system (CNS), mainly expressed in progenitors
+Appears during organogenesis
+Expressed only during active M.tuberculosis infection
+Detected in the ground tissue of late heart-stage embryos. After germination, expressed also in the L1 layer throughout the shoot apical meristem including the peripheral zone. Detected in most tissues of young leaf primordia, except in the presumptive vasculature. In mature leaves, expressed in bundle sheath cells. Detected in inflorescence stems in a single internal cell layer corresponding to the starch sheath
+Exhibits biphasic expression during development
+Up-regulated during osteoblast differentiation. Detected at low levels in mature osteoblasts
+Expression occurs in R3, R5 and transiently at lower levels in R2
+Expressed throughout embryogenesis (PubMed:11444019). After birth, there is a rapid increase in expression within the first week of life, reaching adult levels by week 2 (PubMed:27141234)
+Expressed in brain and spinal cord at 10 dpc. Expressed in brain, spinal cord, cranial and spinal ganglia, lens, retina, cochlea, olfactory epithelium and pituitary at 12 dpc. Expressed in intestine, bladder endothelium, retinal ganglion cells, nephrons, bronchial epithelium, secretory epithelium of submandibular glands, tubular epithelium of the epididymis, ectodermal invaginations of mammary buds and vibrissae follicles, incisors and molars at 15 dpc
+Detected in the embryo from 7 dpc to 17 dpc
+Expressed within 48 hours after sowing, as well as in 10-day-old plants and flowering panicles
+Expression increases during entry into stationary phase
+Low basic levels throughout the growth phase; increases at least 20-fold at the beginning of the autolytic phase and decreases again thereafter
+Expressed both maternally and zygotically, from ova through to 48 hours post-fertilization
+At 7.5 dpc, expressed in allantois and anterior visceral endoderm. In the embryonic part, present in mesoderm migrating laterally but not in the primitive streak; the expression is not apparent in ectoderm or endoderm at this stage. At 8.5 dpc, no expression is found in mesodermal tissues, while it is expressed in midbrain and isthmic regions of the neuroectoderm; it is also found in the pharyngeal region of the foregut. At 9.5 dpc, the expression is found throughout the undifferentiated neuroectoderm, except the telencephalic region. The expression is also ubiquitous in the epidermis; it is especially apparent in the ventral body wall. Also expressed in dorsal root ganglia of neural crest origin. The expression persists in the anterior gut and is also found in bulb arteriosus, kidney, and several connective tissues. At 12.5 dpc, the expression is greatly reduced in most of the neuroectoderm, but some expression remains in pons, anterior tectum, tegmentum, pretectum, prethalamus, mammillary region and hypothalamus. In telencephalon, expression is present in the differentiating preplate of the cortex. The expression is sustained in the epidermis of the whole body. In 14.5 and 18.5 dpc brain, expressed in differentiated fields of the cortex; no significant expression is found in other parts of brain or in the spinal cord. The expression is also present in a variety of connective tissues and in the epidermis of the whole body
+Detected as early as postnatal day one with increasing expression levels through 20 weeks after birth
+Specifically expressed at high levels in pre-comma stage XO embryos. Also present at low levels throughout other larval stages in XO animals, but are nearly undetectable in XX larvae and adults of both sexes
+Most abundant in male embryos (PubMed:33372658). Expressed at low levels in hermaphrodite embryos (PubMed:33372658)
+Expressed during seed development. Expressed in cotyledons 110 and 120 days after flowering (DAF). Not expressed in pericarp, root of 30-day germinating plantlet or young leaf
+Detected in the cerebral cortex from embryonic stage 11 dpc through to postnatal stage P3, where it is primarily expressed in neural precursors
+Turned off in siliques when they reached full maturation. Not expressed in developing or mature embryos
+First detected on embryonic day 18 and increases steadily towards adulthood
+In flowers, present in pistils and in the adaxial and abaxial epidermis of the petals (PubMed:21527560). Maximal enzyme activities are reached at the second day after anthesis when flowers are fully opened (PubMed:21527560)
+Highly expressed in developing nervous system
+During leaf developlement, expressed in young leaf primordia, hydathodes of young leaf tips, hydathodes of the lobes in maturating leaves and lamina within the minor veins in adult leaves. During flower development, expressed in developing stamens, germinating pollen grains, ovules and developing seeds
+First observed in seedlings and in the primary root tip and mature portion of the root (PubMed:27449211). Expressed in the basal region of the hypocotyl, localized with inner/stele-side polarity in the endodermal cells (PubMed:27449211). In the tip of cotyledons, accumulates mostly in epidermal cells of the top side, with a polar localization toward the inner side of the cotyledon (PubMed:27449211). High levels in the transition and differentiation zones of roots, localized with stele-side polarity in the epidermal and endodermal cells (PubMed:27449211). In the root meristem zone, present in epiderm, endoderm, columella, parts of the lateral cap, quiescent center (QC), vascular initial and protovascular cells (PubMed:27449211). In the QC, vascular initial and protovascular cells, exhibits an apical polar localization (PubMed:27449211)
+Expressed in QR and QL neuroblasts, P and V cells and all their respective descendents, M cells, BDU interneurons, ALM and HSM neurons, body wall muscles, I4, all ventral cord neurons and in a few unidentified neurons in the head behind the posterior bulb of the pharynx during the L1 stage of larval development (PubMed:15750187). Expressed in V cell descendents from the larval stage of development to adulthood (PubMed:15750187). Expressed in the midbody dopaminergic PDE neurons throughout life (PubMed:23788625)
+First detected at the tight mound stage. Highly expressed in fingers and late culminants. In slugs, detected in prespore cells, but not in prestalk cells
+Expressed in embryo at 11 dpc. Expressed in the spinal cord, including the motor columns, motor axons, dorsal root ganglions, commissural axons and ventral funiculus at 11.5 dpc (at protein level). Detected at 15 dpc in the cortex and cerebellum and at postnatal day 2 in the cerebellum (at protein level) (PubMed:22685302). Expressed in the retinal ganglion layer (RGL) at 12.5, 14.5 and 17 dpc. Expressed in hindbrain (cerebellar plate neurons), midbrain and forebrain at 10 dpc. Expressed in follicles of vibrissae and nasal processes at 12 dpc. Expressed in eyes at 14 dpc. Expressed in spinal cord, heart, liver, forelimb and hindlimb, buds at 14 dpc onwards
+During male gametophyte development, first observed in bicellular pollen, and accumulates gradually during pollen maturation in tricellular pollen and mature pollen
+Not expressed in adults
+At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit posterior to the last somite. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit adjacent to the somite 10/11 boundary
+In the developing gastrointestinal tract, expressed in the intestinal epithelium at 14.5 dpc and in an incomplete ring of cells in the mesenchyme of the esophagus, stomach and small intestine at 16.5 dpc. In the developing skeleton, expressed in the perichondria of the neural arch of developing vertebrae at 14.5 dpc and 16.5 dpc. At 14.5 dpc, also expressed in perichondria of developing ribs. At 14.5 dpc and 16.5 dpc, detected in dorsal root ganglia and neural tube. In developing skin, expression is detected in the most suprabasal layers at 16.5 dpc. Not detected in the lung at 14.5 dpc or 16.5 dpc
+Isoform 2 is expressed in the lens placode at stage 14. Isoform 1 is expressed in the lens vesicle at stage 17. Isoform 1 and isoform 2 are expressed in the lens, isthmus, cranial neuronal tube, dermatome and vitelin vein at stage 19. Isoform 1 and isoform 2 are expressed in the lens equatorial region during 4.5 dpc to 10 dpc
+Expressed in lymphocytes from fetal liver. Expressed in fetal thymus and brain
+Expressed exclusively in early embryos
+Not found in embryos
+First appears around the blastoderm margin prior to the onset of gastrulation. In later gastrulation, expressed in the lateral edges and midline of the posterior neural plate. During segmentation, expressed in stripes at the lateral edges and adjacent to the midline of the neural plate, throughout the hindbrain, with strong expression in rhombomeres 3 and 5, and at the midbrain-hindbrain boundary. At 24 hours post-fertilization (hpf), highly expressed in the central nervous system, including the dorsal neural tube and the midbrain-hindbrain boundary
+Expressed in cilia cells in the spinal canal, pronephros and Kupffer's vesicle
+Expression is low in meronts, but becomes induced in sporonts and spores
+Accumulates transiently in the early stages of seed maturation (PubMed:9870704). Observed in maturating caryopsis 1 week after flowering (DAF). Expressed in tissues where and when starch granules appear. Detected in the pericarp at the early stage with a shift to the endosperm as the endosperm cells are formed. Confined to both aleurone layer and endosperm cells around 15 days after flowering. Also present in the basal part of leaf sheath (PubMed:16087344)
+Expression in embryos is largely restricted to embryonic skeletal muscle lineage. First detected at 9.5 dpc in cells within the first and second branchial arches. At 10.5 dpc, expression was also observed in the myotomal compartment of rostral somites and by 11.5 dpc in myotomes along the whole anterio-posterior axis, as well as in cells within the developing forelimbs and hindlimbs. At 12.5-14.5 dpc, expression was confined to the skeletal muscle lineage (head, neck, trunk, limbs and diaphragm but not cardiac and smooth muscle). At 15 dpc, a peak expression was seen in neonatal limbs
+Expressed in early syncytial embryo (PubMed:1617730, PubMed:1617729). During cellularization, transient accumulation in a striped pattern (PubMed:1617730, PubMed:1617729). From late stage 11 onward, expressed gradually in a small number of segmentally reiterated cells of the peripheral nervous system (PNS) (PubMed:1617730, PubMed:1617729). This expression is specific to the external sensory organs (PubMed:1617730). In the thoracic and abdominal segments, expressed in the trichogen and tormogen cells, two outer accessory cells present in all larval external sensory organs (PubMed:1617730). During the late third larval instar, expressed in many larval and imaginal tissues (PubMed:1617730). Broadly distributed in the disks, but most abundant in the posterior region of the wing pouch (PubMed:1617730). In the leg disk, predominant in a zone largely overlapping the posterior region (PubMed:1617730). In the eye-antenna disk, low level in both the retinal field posterior to the morphogenetic furrow and the central antenna region, while higher levels appears on the margins of the disk and in the vicinity of the morphogenetic furrow (PubMed:1617730). In pupae, expressed in many tissues at this stage, including developing muscle and epidermis (PubMed:1617730). In both microchaetes and macrochaetes of 24 hr pupae, expressed on the notum and the head (PubMed:1617730). Expressed in the tormogen cell and in specific bristle cells (PubMed:1617730)
+Detected in the outer nectary parenchyma cells, the upper part of the filament and the anther stomium. Expressed in spots pattern on the surface of very young nectaries that do not secrete nectar and do accumulate starch. Highest levels in open flowers in which active secretion of nectar and starch hydrolysis have taken place
+Expressed during synaptogenesis with levels peaking during the second week of postnatal development (PubMed:20152115). Expression increases between postnatal days 7 and 14 and remains high at postnatal day 21 and at 2 months of age (PubMed:26660156). As development proceeds, an increasing percentage becomes localized to excitatory synapses (PubMed:20152115)
+Up-regulated during the differentiation of a retinoblastoma cell line
+In unpollinated ovaries, present in the placenta, but not in ovules and pericarp. In pollinated ovaries, accumulates mostly in the placenta and ovules and, at low levels, in the pericarp
+Restricted to proliferating cells. First active during embryogenesis, but inactive in mature embryos. Expressed in shoot and root apical meristems. Later observed in lateral root primordia and meristems. Detected in young flower buds, developing anthers and mature pollen
+Isozyme gamma is first detected during late embryogenesis, is present through larval stages, declines in abundance during pupal stages and is maximum at eclosion. Isozyme beta is abundant during the earliest stages of embryogenesis, declines in amount and increases prior to hatching. Isozyme alpha is found only during the adult stage. Expression correlates to dietary behavior: high dietary activity in the larvae and adults causes active glycolysis and high expression levels. Isozyme alpha-beta is detected in the pupae and adults and isozyme beta-gamma in the adult
+Detected in embryo (at protein level). Detected in endothelium from yolk sac vessels
+Expressed in dopaminergic neurons throughout the life of the neurons
+Faint levels are detectable at embryonic day 14, with levels rising at later embryonic ages and peaking at postnatal day 7
+Highest expression during larval development with a peak at L3 and lower levels in the embryo and adult (at protein level)
+The expression in receptacles is ripening-related, with highest expression detected in red fruit
+Expressed at all stages of the mitotic cell cycle
+Expressed ubiquitously from early embryogenesis (6.5 dpc) to organogenesis, predominantly in neural and epithelial tissues
+Expressed at the early flowering stage and at the late stage of silique development
+Highly expressed on day 2 and 3 after inoculation, a time when the fungus is in a rapid phase of growth. After a stationary phase on day 4, the expression decreases
+Peak of expression in seeds 9 days after flowering
+Expressed in germ cells of 22-week prenatal testis
+Highest levels are observed from day 11 until parturition, with peak levels also on day 13
+Expressed maternally and zygotically (PubMed:1968224). Expressed at high levels in embryos at 0-2 and 8-12 h of development (PubMed:17087725, PubMed:1968224). Moderate levels detected at later stages of embryogenesis, in unfertilized eggs and adult females, and relatively low levels of expression were detected in larvae and adult males (PubMed:17087725)
+During germination, first observed in a subset of protodermal cells, likely meristemoid mother cells (MMCs), both in the cytosol and at the cell periphery (PubMed:21963668, PubMed:30429609). Two hours before each asymmetric division occurs, becomes dynamically localized at the cell cortex distal to the division plane, especially in cells of the stomatal lineage. After asymmetric cell division, up-regulated in only one of the daughter cells that will continue to divide asymmetrically (PubMed:21963668)
+Expressed both maternally and zygotically. All isoforms, except isoform 8.20, are rapidly degraded on cellularisation of the blastoderm embryo
+Detected in testis from 3 weeks of age onwards
+Expressed in spores
+Expressed immediately after neuronal birth and is dramatically down-regulated in the adult
+Detected in maternal serum soon after implantation and throughout the gestation period
+Expression is first detected during mid-embryogenesis with high levels in larvae and low levels in adults
+Haustoria and rust-infected leaves
+Expressed in sepals at stages 11, 12 and 13 of flower development. Highly expressed in petals at stages 9-10, decreases at stage 11 and disappears after flower stage 12. In anthers, expressed at stage 11 in the tapetum, disappears early in stage 12 when the tapetum degrades and reappears throughout the anther late in stage 12 to persist at least until stage 13. In stamen filaments, expressed at stages 12 to 13, especially near the apical end of the filament. Expressed throughout the gynoecium at early stages up to stage 12, especially strongly in ovules. Expression in gynoecium decreases late in stage 12, but persists through stage 13, especially near the apical end including the style
+Accumulates to high levels in intestinal crypt epithelium from 14 days of age to 40 days of age
+Expressed in early mouse embryo, especially in the embryonic gonad from 11.5 dpc. Continuously expressed from newborn testis to adult
+Expressed during development from young seedlings to flowering plants
+In seedlings, strong levels in the hydathode region of cotyledons as well as in the upper part of hypocotyls and weak content in the vascular tissue of cotyledons (PubMed:20011053). In developing leaves, strongly expressed in the midrib of leaf veins, but weak levels in the hydathode regions (PubMed:20011053). In developing flower buds, accumulates in pistil tips and the vascular tissue of stamens and sepals (PubMed:20011053). In mature flowers, detected in the vascular bundles between the two anther locules, the central vascular cylinders of the filaments, vascular tissues of tips of the pistils, and sepal vascular tissue (PubMed:20011053). Also present in tips and bases of developing siliques, and progressively restricted to the vascular tissues at the silique tips (PubMed:20011053)
+Preferentially expressed in endoreplicating cells, such as cells of the apical hook of dark-grown seedlings
+Maternally expressed. Strongly expressed in the anterior neural plate at stage 18. Expressed in the migrating cranial neural crest and the developing eye at stage 23. Also expressed in the midbrain-hindbrain boundary, migrating neural crest cells and the periocular mesenchyme at stages 26-31. Expression appears to require Wnt-4 activity
+Highly expressed during embryogenesis, weakly expressed during larval stages
+Up-regulated during seed germination and early postgerminative seedling growth
+During embryogenesis, detected in liver, lung, skeletal muscle and placenta
+First detected in the chordamesoderm of the dorsal blastopore lip of the mid-gastrula embryo (stage 11). This tissue, which differentiates into the notochord. In late gastrula embryos (stage 13), it is highly expressed in the notochord, and the original expression domain expands to include the tissue surrounding the blastopore. In neurula embryos, it is maintained in the notochord and the circumblastoporal region and now also extends to the paraxial mesoderm and the neuroectoderm. By the tailbud stage, it is expressed in various mesodermal and neural tissues. Highly expressed in the brain and the neural tube. Maintained throughout development to the tadpole stage (stage 35)
+Expressed during all stages of development
+Expressed in fetal lung, kidney and brain
+Expressed during the growth-phase and down-regulated to barely detectable levels upon starvation
+During osteoclast development, expression is abundant in early osteoclast precursor cells, decreases as the cells differentiate and is almost absent in mature osteoclasts
+Larval-specific
+Expressed in all stages of the life cycle
+In 15.5 dpc embryos, it is strongly expressed in the liver, specific regions of the central nervous system, the thymus, the lung, and the cartilage perichondrium. In adult it is markedly present in the brain and the thymus and at different stages of spermatozoa maturation in the seminiferous tubules
+Expressed in all 3 inner integumenta layers and 2 outer integument layers in young seeds, but specifically restricted to the inner integumenta in mature seeds
+Expressed during the young seedling stage
+Highly expressed between 10.5 dpc and 12.5 dpc. Expressed in the midbrain, forebrain, hindbrain and dorsal root ganglia of embryos at 12.5 dpc
+Low expression from 4.5 dpc onwards. Expression increases at 10.5 dpc and decreases after 15.5 dpc. At 11.5 dpc, broadly expressed in the telencephalic and diencephalic vesicles. This pattern of expression continues until 17.5 dpc
+High level of expression at the vegetative stage and the first hours of development
+Up-regulated during stationary phase
+Expressed from 14 days postnatal day
+Exponential increase between days 25 and 30 after birth
+Highly expressed in the developing brain
+Highly expressed at day 7 of embryonic development and detected throughout the later stages of embryonic development
+In the thymus, levels increased during fetal development, were highest in newborn animals and decreased in the adult. In the testes, the PLK levels were higher in the adult than in prepubescent mice while in the ovary, the levels were higher in the prepubescent mice. Accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase
+During seed development
+Expressed exclusively in the ovary, and protein localizes to the Balbiani body during oogenesis and with the germ plasm during early embryogenesis (PubMed:19249209). Accumulates at embryonic cleavage furrows (PubMed:26253407)
+At stage 9 detected in centrally located anterior polar cells, and in border cells before and as they migrate (at protein level). At stage 10, detected in centripetal cells and levels decrease in border cells as they finish migrating (at protein level)
+Expression restricted to early to mid-stage of silique development. Not found in vegetative stage. Expressed in the micropyle area of the ovule just after fertilization
+At 9.5 dpc, detected at low levels in the developing heart and central nervous system. At later stages of development, widely expressed, predominantly in the heart and brown fat tissue
+Highly expressed in testis during spermiogenesis. Expression was almost undetectable in testes at postnatal day 14 (P14). However, by P23, a strong increase in mRNA levels was observed with expression persisting to P40 when spermatozoa were first observed. Up-regulated in the uterine luminal epithelium at the time of embryo implantation
+Expression first seen in late embryonic stages and continues in larval and adult stages
+Continuous expression during the fruit development
+Detected in the cerebral cortex from 12.5 dpc until birth, with highest levels in the frontal and parietal parts of the neocortex than the occipital parts
+At postnatal day 2 (P2) and P4, is detected in immature oligodendrocytes, where it was predominantly found both in the processes and cell bodies. In contrast, at P12 and P14, it is found mainly in myelin sheaths
+Expressed in fetal cochlea
+Expressed at low levels in testis between P3 and P14. Expression in testis increases at P20 and reaches maximum levels in adult
+Expressed primarily in vegetative cells
+Widely expressed until 24 hours post-fertilization (hpf), probably due to inheritance of maternal transcripts. Expression becomes restricted to lens, pharyngeal region, liver/pancreas anlage and intestine at 48-72 hpf. Strongly expressed in pancreas and intestine at 96-120 hpf
+Expressed during flower development in floral meristem, sepals, petals, developing carpels, growing integuments and tetrads of megaspores. In mature ovules, expressed in the cells of the embryo sac. Expressed in the sporogenous cells, tetrads of microspores and mature pollen in stamens After fertilization, expressed in the embryo and endosperm at the globular and heart stages. The progressively decreases during ovule development and is not observed in the developing seed coat
+Expression was detected at day 15, coinciding with the beginning of implantation, and continued throughout gestation
+Expressed during all developmental stages
+Expressed in the developing eye. In 48h embryos, enriched within the periocular mesenchyme (POM), in the branchial arch region and in the developing pancreas
+Highly induced during senescence
+Detected at 7 dpc, levels increase from 11 dpc to 17 dpc
+Isoform 2 expression is down-regulated during myeloid differentiation, while the expression of isoform 1 and isoform 3 remain constant
+Expressed zygotically. First detected at the tail bud stage and continues to be expressed for at least the first 48 hours of development
+In early embryos before gastrulation, it is specifically expressed in the distal-most part of the extraembryonic ectoderm, adjacent to the epiblast. Expression is highly restricted to the developing pharyngeal endoderm and mesonephros until day 11.5 of embryogenesis
+Expression drops sharply after germination and increases again in the mature plant
+Expression is increased in smooth muscle cells during dedifferentiation from the contractile to the synthetic phenotype
+In the inner ear, between 16 dpc and P1, present along the sterocilia of outer hair cells, but almost undetectable in inner hair cell hair bundle. From P3 onward, expression in outer hair cell bundles is restricted to their base and it is also expressed at the base of inner hair cell stereocilia
+Expressed in embryos and early cleavage stages (at protein level). Maternally expressed. Expressed in early cleavage embryos, weakly at 4 hours post-fertilization (hpf) and undetected at 24 hpf
+Expressed during the asexual blood stage, including in merozoites (at protein level)
+Expressed both maternally and zygotically. Expressed throughout embryonic development
+Expressed from 7-day-old embryos
+During flower development, first observed in petals after about 40 hours, with a sharp increase between 32 and 48 hours, and a decrease during flower senescence
+Expressed at 18 dpc in hippocampal neurons
+First observed at 5 days post anthesis (DPA). Accumulates throughout subsequent stages of embryo development, in embryonic tissues such as cotyledons and embryo axis as well as in the endosperm. In young seedlings, strictly confined to the cotyledons, hypocotyl and root tip, 3-4 days after germination. Also detected in the trichomes of new leaves
+Expressed both maternally and zygotically. At least one isoform is present at each developmental stage. Isoform D is restricted to early embryogenesis (at protein level)
+Expressed in the lens placode at stages 5, 8 and 14. Expressed at stage 18 when the invaginating lens placode closes to form the lens vesicle
+Expressed during the asexual blood stage, in schizonts and free merozoites (at protein level)
+Expressed at low level in G1 and is induced in S and G2 phase, during which point centrioles have already commenced duplication (at protein level)
+Expressed in the second stage of root nodule formation
+Ubiquitously distributed in embryos from early cleavage stages through to 2 dpf
+Expressed in the prospective head ectoderm and the Spemann organizer at gastrula stage. Expression increases during gastrulation and decreases during early neurulation. As gastrulation progresses, expression occurs in the anterior neuroectoderm, after mid-gastrulation, expressed in the superficial layer. The expression in endomesoderm concomitantly becomes restricted to the future prechordal plate territory. At the mid-neurula stage, the ectodermal expression declines, while that in the prechordal plate persists until the late-neurula stage
+Not detected before gestational days 53-54. Expressed in the eye at gestational week 10
+Detected as early as 18 dpc in the developing cerebral cortex, and expression reaches its peak at P1, declines after P10, and remains at a relatively low level throughout adulthood. At 18 dpc, expressed in the forebrain, midbrain, and hindbrain. Within the forebrain, it is expressed in postmitotic cells of the cortical plate. At this stage, it can also be detected in other structures of central and peripheral nervous systems, including the trigeminal ganglion, superior cervical ganglion, retina and olfactory epithelium. Expression in the cortex is high at birth and declines substantially by P20. At P7, expressed in all cortical layers, and in the hippocampus, expression is high in the cell body layers of all subdivisions. Within the brain, expression decreases through development but continues to be expressed at high levels in the olfactory bulb, hippocampus, and cerebellum into adulthood
+During seed development, highest expression is found in the seed coat of young seeds. Expression decreases steadily during further seed development but is detectable until desiccation begins
+Expressed in ovaries, early embryo (0-4 hours) and adult males. Almost undetectable in female carcasses. In ovaries, it is not detected in the germarium or early stage egg-chambers and is first detectable in the follicle cells of stage 8 egg-chambers. The peak of expression occurs in the follicle cells of stages 9 and early 10, and it disappears completely before stage 11. Not expressed in the germline cells (nurse cells and oocyte), with the possible exception of late stage 10 nurse cells
+Expressed in most cells of the cleavage stage embryo, apart from a few cells at the posterior pole, from the 20 cell stage to the 200 cell stage (PubMed:12568714). Expressed in a few neurons in the head of young larvae (PubMed:12568714)
+Low levels detected at 10 hours post-fertilization (hpf) with negligible levels at 24 hpf and 48 hpf, and increased levels at 72 hpf
+Up-regulated during L3 developmental stage in distal tip cells
+Meiosis-specific. Expressed from 3 to 9 hours after induction of sporulation. Not expressed during mitosis
+Expressed in the pharynx from the embryonic stage to adulthood
+Expressed both maternally and zygotically. Abundant in oocytes and expressed in embryos at a lower level, dropping between embryonic stages 6.5 and 12
+First detected at 12.5 hours post-fertilization, continuing through to adult stages. At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression at somite 1. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit at the anterior-most region of somite 1
+Expressed in the developing embryo excretory and central nervous systems. In the developing excretory system; expressed in the pronephric tubules and extending nephric duct beginning at day 9 gestation. At 10 dpc, detected in the nephric cord, Wolffian duct and also individual pronephric tubules. At 11 dpc, expressed in the branched ureter and the mesenchymal condensations, at 12 dpc, expression seen in the collecting ducts and condensed mesenchymal cells. At 14-17 dpc, expressed in the perimeter of the growing kidney but expression declines in the more developed glomerular crevices, and at later developmental stages expression in the kidney declines. In the developing CNS; initially expressed in the ventricular zone in two compartments of cells on either side of the sulcus limitans and along the entire rhombencephalon and spinal cord, later is restricted to progeny cells that have migrated to specific regions of the intermediate zone. In the eye, expression is restricted to the ventral half of the optic cup and stalk and later to the optic disk and nerve. In the ear, expression is restricted to regions of the otic vesicle that form neuronal components
+Expressed at the 4-cell stage embryo. Expressed at gastrula stage in the ventral blastopore lip and the anterior end of the notochord. Expressed at early neurula stage throughout the notochord, the posterior paraxial mesoderm, cranial neural crest, anterior edge of the neural plate and at the prospective midbrain-hindbrain boundary (MHB) or isthmus organizer. Expressed at late neurula stage in the posterior neural fold. Expressed at early tailbud stage at the MHB until tadpole stage. Expressed at tailbud stage in the branchial arches, ear placode and ventral mesoderm
+Expressed from 12.5 dpc until adult in male gonads. In female gonads, detected since 12.5 dpc, then begins to cease after birth and disappears until the development of adult ovary (PubMed:11578866). Highly expressed in embryonic male germ cells at embryonic day 16.5 and expression decreases by postnatal day 2.5 (PubMed:32381626)
+Expressed both maternally and zygotically. Expressed ubiquitously throughout gastrulation. At the tailbud stage, expressed at higher levels in the anterior and tailbud. Also expressed in migrating cranial neural crest cells
+Expression occurs early during skeletal development and is restricted to cells of the mesenchymal condensations and of the osteoblast lineage. Expression of isoform 2 in the embryo reaches a peak at 12.5 dpc
+Expressed at 8.5 dpc in the anterior section of the primary head folds. Ubiquitously expressed at 9.5 dpc with higher expression in forebrain, mesenchyme of the branchial arches, nasal pits, limb buds and mesonephric ducts. Also detected at 10.5 dpc in hindbrain and lateral region of the neural tube
+Expressed at a low level in vegetative cells; not expressed between the onset of development and aggregation, and is then re-expressed in the multicellular aggregate stages
+Mostly observed in vegetative, inflorescence and floral meristems as well as in young leaf and floral organ primordia. Strongly expressed in developing ovules and during early embryogenesis. Expressed evenly throughout the endosperm and the embryo in developing seed. Present in the embryo proper, but excluded from the suspensor, until the late heart stage, and fades out later, especially in the hypocotyl region, to be present at low levels throughout walking-stick embryos. Accumulates at the margins and in the tips of cotyledons and lateral organs, in the apical meristem, in a subset of cells at the root pole and in a restricted number of cells within the presumptive vasculature of the hypocotyls. Also detected during early endosperm development, prior to cellularization
+Strongest expression at 7 dpc. Marked decrease 11, 15 and 17 dpc
+Expressed zygotically, with greatest expression at 24 hours post-fertilization (hpf). At 9 hpf, shows ubiquitous expression in the epiblast. At 10 hpf, expressed in anterior and posterior regions; not expressed in the presumptive hindbrain, and anterior expression is limited to mesoderm adjacent to the head. Between 11-15 hpf restricted expression in the cranial mesoderm and tailbud. At 12 hpf, expressed in anterior lateral mesenchyme, with strongest expression lateral to the future hindbrain, and in tailbud. At 24 hpf, also expressed in the hindbrain, neural crest cells and tail; not detected in spinal cord. At 48 hpf, hindbrain expression increases with an anterior border at rhombomere 3 and a posterior border at the spinal cord/hindbrain junction; expressed in stripes one rhombomere wide in dorsal hindbrain. At 48 hpf, also expressed in pharangeal arches 1-7, anterior neurocranium, cells separating the eyes and forebrain, pectoral fin buds and tailbud. Embryonic zygotic expression overlaps that of raraa and rarab, but there is stronger expression in the posterior hindbrain beginning in late somitogenesis, and in neural crest cells in the pharangeal arches. In the adult, strongly expressed in the ovary, brain and muscle, and weakly expressed in the liver and digestive tract
+Expressed at high levels at 8.5 dpc and its expression level gradually decreases during embryogenesis. At 12.5 dpc, is expressed throughout the developing nervous system. It is expressed in both the ventricular zone and the mantle layer of the developing brain. At 14.5 dpc, expressed in the cortical plate as well as in other regions of the brain. Also expressed at a high level in the spinal cord and dorsal root ganglia. Expressed by almost all cells in the spinal cord and dorsal root ganglia at this stage. At later stages, expression is gradually restricted to several regions such as the hippocampus, cerebellum and retina. In the hippocampus, a high level of expression continues during embryogenesis until adulthood. Expressed in the CA1-CA3 regions and the dentate gyrus. At 18.5 dpc, expressed in cerebellum by Purkinje cells and granule cell precursors in the external granular layer (EGL). By postnatal day 4, expressed by aligned Purkinje cells and by the EGL and internal granular layer (IGL) cells. In the adult cerebellum, expressed at a high level by Purkinje cells and weakly by granule cells in the IGL. In developing retina, expressed in both the ganglion cell layer and the ventricular zone at 11.5 dpc and 17.5 dpc. Expression becomes very weak in the adult retina. Early in metanephric development, expressed in metanephric mesenchyme but not ureteric bud-derived cells, with overall expression being most abundant in the nephrogenic zone. From 14.5 dpc to birth, expressed at constant levels. By day 13, corresponding to the end of new nephron induction, expression levels begin to decline. By day 19, expression returned to fetal levels, and by day 40, the low level of expression that persisted into adulthood is established. In adult kidney, expression is restricted to podocytes. Expressed in pancreatic tissue from 12.5 dpc until 17.5 dpc. Is still detectable at low level,at postnatal day 1 and in isolated pancreatic islets in adult (PubMed:18560595)
+The different late H2A and H2B mRNAs are present in as few as 200 copies in the egg and each accumulate to 3-5 x 100000 molecules in the gastrula embryo. The H2A-3 mRNA is also abundant in testis RNA and codes for the H2A variant present in sperm chromatin
+Expression detected after 9.5 dpc in the endothelial layer of the forming heart, neural tube, brain and septum transversum. At 10.5 dpc, expressed at high levels in the prosencephalon and in a part of the rhombencephalon and at lower levels in the neural tube, somites and heart. Detected in liver at 11 dpc and 13 dpc, but not at 15 dpc and 17 dpc. During heart development, expression detected mainly in endocardial cells and endocardial cushion mesenchymal cells in both outflow tract and atrioventricular canal regions and to a lesser degree in myocardial cells at 10.5 dpc, in the mesenchyme of the forming valves and in numerous microvessels in the myocardium at 12.5 dpc, and from 14.5 dpc onward mainly in the microvasculature associated with myocardium, valves and great vessels. In developing telencephalon, observed at 11.5 dpc in the ventral telencephalon in proliferative zones of the medial ganglionic eminence (MGE), in ventral part of the lateral ganglionic eminence (LGE) and in Cajal-Retzius (CR) neurons of dorsal telencephalon. At 12.5 dpc, detected in migrating olfactory tubercle neuron precursors and cortical interneurons, and in CR cells and subplate neurons of the cortex. At 13.5 dpc, observed in the germinal zone of MGE in the subpallium, in the marginal zone and cortical subventricular zone (SVZ) of the lateral cortex as well as in pyramidal cells and tangentially migrating interneurons. At postnatal stages, expressed in postnatal cortical plate and in migrating olfactory bulb interneurons in the striatal SVZ and rostral migratory stream. Expressed in the developing neuroepithelium in the region of the developing oculomotor nucleus at 11.5 dpc and 13.5 dpc (PubMed:31211835)
+Plays an essential role during early development
+Not detected in 12-week virgin mammary glands. Expression increases (at protein level) six-fold during pregnancy and remains at this level during lactation. During involution, a slight increase is observed at days 2 and 8 followed by a sharp decline at day 15
+First detected between days 2.5 and 3 of incubation (stages 14-15 and 18-17) until day 10 (stage 36). Maximal levels are observed at stages when the spinal cord has maximal mitotic activity. It becomes undetectable when the ventricular zone ceases to exist
+First detected in the eye at 17 dpc and maintained into adulthood
+Abundantly expressed at all embryonic stages but not present in adult tissues
+Highest expression in third instar larvae and prepupae
+Expressed in the cerebral cortex from 13.5 dpc to P30, expression peaks at P15
+Isoform 1 is expressed in fetal brain. Isoform 2 is expressed in fetal heart, brain, thymus, lung, liver, skeletal muscle, kidney and spleen. Isoform 4 is expressed in fetal heart, brain, thymus, lung and skeletal muscle
+Highly expressed in the conceptus ectoplacental cone of the placenta at embryonic day 7.5 dpc (PubMed:16759287). Expressed in the conceptus trophoblast giant cell layer of the placenta (PubMed:16759287). Expressed in the trophoblast giant cells of the placenta from 10 dpc, expression peaks at 14 dpc, then reduces thereafter to 18 dpc (PubMed:16759287). Expression is increased during trophoblast differentiation (PubMed:16759287). Expressed at 8.5 dpc in developing embryos, with increased expression at 9.5 dpc (PubMed:10821863)
+Down-regulated during adipocyte, kidney, and heart differentiation
+Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver
+First observed in lateral root primordia (LRP), from the first pericycle divisions. Later expressed in lateral roots. Expression is greatly increased in leaves during leaf senescence
+Expressed both maternally and zygotically in embryos, larvae and adults
+During embryonic brain development detected in the cerebral cortex at 14 dpc; expressed in the walls of the third and fourth ventricles, and in the hippocampus. In the adult brain, predominantly expressed in Purkinje cells of the cerebellum and neurons in the CA3 region of the hippocampus (PubMed:18619852)
+During embryo development, expressed in all cells at the 4- and 16-cell embryo stages (PubMed:25564655). Expression is restricted to the protoderm from the globular stage onward (PubMed:25564655). In primary and lateral roots, observed in the epidermis, the outer layer of columella cells and lateral root cap (PubMed:25564655)
+In flowers, expressed in anthers, upper region of style, stigma and pollen from dehisced anthers
+First expressed in comma stage embryos, continuing into young adult hermaphrodites (PubMed:22207033). Expressed in the single interneuron DVC, in the tail ganglion, from larval L3 stage and throughout lifetime (PubMed:22207033). Expressed in the ut2 and ut3 cells in the uterus in young adults (PubMed:22207033)
+Detected in stomach and skin from embryonic stage 16 (16 dpc) onwards
+Expressed in ovarian follicles (from the primordial through to the secondary stage), in mature oocytes, and less frequently in preimplantation embryos
+Expressed in the developing nervous system. Expressed at 9.5 dpc in the geniculate (VIIth), petrosal (IXth), and nodose (Xth) ganglia. Expressed in postnatal eyes
+Expressed upon sporulation
+At 36 hpf, expressed predominantlyin the brain, including several discrete regions in the forebrain, midbrain and hindbrain
+Expressed in lens at 24 hours post-fertilization
+Strongly expressed in 2-cell embryos with weak expression detected in other embryonic stages. Also weakly expressed in adult testis
+Expressed in primordial germ (PGC), embryonic germ (EGC) and embryonic stem (ESC) cells. Not detected in embryonic carcinoma (ECC) cells
+Expressed during embryonic development (at protein level)
+Expressed in cells of the developing embryo (PubMed:15704008, PubMed:17574230). At the larval stages, weakly expressed in neurons and pharyngeal secretory cells (PubMed:15704008, PubMed:17574230). At larval stages also expressed in the developing hermaphrodite vulva and male tail (PubMed:17574230). Not expressed in the gonads in larval stages (PubMed:15704008)
+At 9.5 dpc, expressed in the chorionic plate and ectoplacental cone. From 10.5 dpc to at least 11.5 dpc, is also expressed in the trophoblast cells of the three placenta layers (PubMed:15509779). Expressed in monocytic precursors but is vanished during differentiation into osteoclasts. The expression increases during osteoblast differentiation (PubMed:19440205)
+Up to the comma stage, expressed in six lineages that produce diverse cell types including pharyngeal cells, muscles, neurons and glia
+In the oocyte, the protein accumulates from stage 1 to stage 5/6 of oogenesis and persists through gastrulation while the somatic protein begins to accumulate at early cleavage and, by the neurula stage, is the dominant, if not exclusive, form present
+Expressed both maternally and zygotically. Transcripts are first detected in the gonads of postmetamorphic froglets, being present in the embryo at the time when germ plasm moves to its perinuclear location (stage 10) and then decreasing in stages immediately following. Protein is expressed in embryos from the blastula to the early tailbud stage
+Expressed in early embryos at the 4-cell, blastocyst (3.5 dpc) and epiblast (7 dpc) stages (PubMed:12620990, PubMed:21425410). Expression is restricted to the interior part of the morula and the inner cell mass (ICM) of the blastocyst (PubMed:21425410). Detected in primordial germ cells (at 10 dpc) and undifferentiated embryonic stem cells (PubMed:12620990, PubMed:21425410)
+Expressed in the embryo during all developmental stages
+Strong reduction in expression levels in flowers following fertilization
+Detected in embryos at 14.5 dpc, but not at 10.5 dpc and 19.5 dpc. Preferentially expressed in the neuroepithelia of the isthmus and septum of the embryonic brain at 14.5 dpc
+Expression starts at the 100 cell stage during embryogenesis and is expressed throughout development until adulthood
+Expressed in germinating seeds and during cotyledon development
+Present following meiosis I (at protein level)
+At postnatal day 3 isoform 1 is expressed in the retina in a narrow band at the developing photoreceptor layer; expression in this band persists through to postnatal day 14 but becomes severely diminished in the adult retina. Isoform 5 is first detected in the retina at postnatal day 14 and is expressed at increased levels in the adult retina (at protein level). Expressed throughout embryonic development from day 7 of gestation. Also expressed in adult
+Detected in tachyzoites, bradyzoites and sporozoites
+First expressed in unhatched larvae; continuous throughout subsequent larval stages and in adults
+Expressed in intestine from larval stage L2 onwards. Not detected in embryos
+Maximally expressed in early stationary phase in medium containing glucose and glutamine
+Expressed throughout mouse embryogenesis.A transient increase is observed from 5.5 dpc to 7.5 dpc
+Can be detected in regions including primordial retina and neuroepithelium by embryonic day 2 (E2). At 3 dpc, expressed in the temporal retina and associated pigment epithelium as well as in part of the diencephalon, and at 7 dpc is expressed in retinal ganglion cells. Levels begin to decline from 4 dpc and almost disappear by 10 dpc
+Expressed both maternally and zygotically. Expression decreases from the mid-blastula stages onwards before increasing again at the start of gastrulation
+Primarily expressed in the central cell gamete of nonfertilized ovules, which upon fertilization gives rise to the endosperm, and later in the micropylar endosperm, which surrounds the embryo
+In leaves, level increases gradually up to the point of leaf senescence
+In cerebral cortex first detected at 15.5 dpc with increasing levels of expression observed during postnatal stages
+Detected two days after germination and reached a maximum at three days of growth
+Expressed in both vegetative cells and in N(2)-fixing heterocysts; considerably more abundant in heterocysts (at protein level)
+First detected at 11.5 dpc in the presumptive testis (PubMed:8805249). No expression in the ovary at this or any later time (PubMed:8805249). At 12.5 dpc testis expression is confined to Sertoli cells and is not detected in precursors of the androgen-producing interstitial somatic cells (the Leydig cells) (PubMed:8805249). At 13 dpc expressed by Schwann cell precursors both in the dorsal and ventral roots and in the emerging spinal nerves (PubMed:10482238). Expressed in Schwann cells of newborn (PubMed:10482238). Expressed primarily within the valve endocardium at 15.5 dpc with lower levels of expression within the trabeculated endothelium, primary atrial septum and epicardium (PubMed:32151560). Expressed within the valve endocardium at embryonic, fetal and neonatal timepoints with evidence of protein diffusion into the interstitium (PubMed:32151560). Primarily expressed within the atrialis aspect of the anterior and posterior mitral leaflets with the highest signal present at the valve tip (PubMed:32151560)
+At embryonic day 11.5, it is expressed in the differentiating zones of various regions, such as the caudate-putamen, the geniculate body, the thalamus, the amygdala and the brainstem. This expression persists in the adult, although expression is lower. After birth, highly expressed in the glomerular and mitral layers of the olfactory bulb, the cortical plate of the neocortex, the cochlear nucleus, and the molecular and granule cell layers of the cerebellum. In the hippocampus, expression is first observed in the dentate gyrus at postnatal day 7
+At stage 13 it is detected in the presomitic mesoderm, transiently observed before segmentation, and in the rostral part of the neural tube. Up-regulated in the neural tube, the retina and the otic vesicle from this stage on. At stage 17 a distinct stripe pattern was clear in the hindbrain and the spinal chord. Also found in the neuroepithelium of the midbrain and forebrain. The expression was down-regulated with the termination of neurogenesis at stage 36
+Appears soon after starvation and then remains at constant levels throughout development
+Expressed throughout development. Highest expression in segmenters stage followed by schizonts stage
+First detected in gastrulation stage embryos (6.5-7.5 dpc) in ectodermal cells adjacent to the distal region of the primitive streak. By the neural plate stage (approximately 7.5 dpc), EPHA2 expression becomes restricted to the extreme distal end or node of the primitive streak. After the beginning of somitogenesis (approximately 8.0 dpc), expression persists in the node as this structure regresses toward the caudal end of the embryo. In addition, beginning at the mid head fold stage (approximately 7.75 dpc), we observe that EPHA2 exhibits a dynamic and spatially restricted expression pattern in the prospective hindbrain region. EPHA2 transcripts are initially detected in a 5-cell wide strip of mesodermal cells underlying prospective rhombomere 4 (R4). Subsequently at the beginning of somitogenesis, expression is observed in prospective R4. At the 4-8-somite stage, EPHA2 transcripts are observed in R4, mesenchymal cells underlying R4, and surface ectoderm in the vicinity of the developing second branchial arch. By the 10-somite stage, expression in these cells is down-regulated. Additionally, at the 5-8-somite stage, EPHA2 transcripts are detected initially in the lateral mesenchyme immediately underlying the surface ectoderm adjacent to R5 and R6, and subsequently in surface ectoderm overlying the developing third branchial arch. In myogenic progenitor cells, expressed during the acquisition of muscle stem cell properties, from 18.5 dpc to adulthood (PubMed:27446912)
+Before anthesis, expressed in the vascular bundles of spikelets and at low levels in the central region of anthers. After fertilization, expression in bundles increases especially in the upper part of the husk. At 5 days after anthesis, highly expressed in the developing ovary and 3 days later in the developing embryo and outer layer of the endosperm. From 20 to 30 days after anthesis, expressed in mature embryo and peripheral layer of the endosperm
+Detected throughout the epidermis in young seedlings, and accumulates progressively during epidermal cell maturation, especially in stomatal lineage cells with asymmetric cell division (ACD) potential
+Detected in lymph glands from late third-instar larvae (at protein level)
+Expressed maternally and zygotically. Expression of the maternal transcript decreases until embryonic stage 14, zygotic transcript is first detected at stage 11
+Expressed in embryos and adults (PubMed:11748140). First expressed at the nuclear envelope of migrating hyp7 nuclei, then, at the bean embryonic stage, it is expressed in hyp7 cells, P cells and intestinal cells (PubMed:11748140)
+Produced by third-instar larvae
+First detected in the embryo and persists throughout development (at protein level)
+High expression during embryonic development does not seem to be associated with the differentiation of any particular cell type, but is widely utilized when there is a requirement for cell movement. Frequently associated with less differentiated cell types and down-regulated with subsequent differentiation. Detected in sites with hemopoietic potential: the yolk sac (7.5, 8.5 and 12.5 dpc) and fetal liver (12.5 dpc). During gastrulation, at 7.2 to 7.8 dpc, expressed in the mesoderm and the definitive endoderm. As gastrulation pattern fades (8.5 dpc), expression in the mesoderm is down-regulated, while it becomes predominant in neural ectoderm. Endodermal expression is retained in the foregut and later in a subset of foregut derivatives, including the stomach (10.5 dpc), the cystic ducts of the gall bladder and the lung epithelium (12.5 dpc). In neuronal tissue: at 10.5 and 12.5 dpc, expressed in the dorsal root ganglia, in the ventral mantle layer of the spinal cord (or basal plates), in the hindbrain. At 14.5 dpc, expression more tightly confined to the neural epithelium lining the ventricular space and to the external granular layer of the ventral rhombic lip (the developing cerebellum). Expressed in the outpocketing of the diencephalic floor at 10.5 dpc and in the developing thalamus and, to a lesser extent, the developing hypothalamus. At 14.5 dpc, restricted to the region where thalamus and hypothalamus meet. Detected in a discrete band of cells at the edge of the olfactory bulb. In the vascular system: expressed in the endothelium of numerous blood vessels, but not all, at 10.5, 11.5 and 12.5 dpc, such as vitelline/umbilical vessels, cardiac ventricular wall capillaries, facial vessels and, at 14.5 dpc, in the vasculature of the herniated gut. Expression seems to be associated with expanding vascular networks. In the heart development, expressed at 10.5 dpc in the precursor to the aortopulmonary (AP) septum. At 12.5 dpc, detected in the AP septum at the base of the outflow tract and in the atrioventricular valves. Detected in cranofacial ectoderm from 10.5 to 14.5 dpc. At 10.5 and 11.5 dpc, expressed in the Rathke pouch
+Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle
+At 11 dpc, expression was restricted to the olfactory pit, the basal and rostral surface of the telencephalic vesicle, the eye anlage, the epithelium of Rathke pouch, and somites. At later developmental stages, it was widely distributed in neuronal as well as in mesenchymal and epithelial structures outside the nervous system. After birth, mesenchymal levels decreased rapidly and expression became restricted to specific sets of neurons in the CNS. In the mature CNS, it is detectable in mitral cells, neurons of the accessory bulb and cerebral cortex, cerebellar Purkinje cells, as well as a subset of cranial and spinal motoneurons
+Expressed transiently at the early stages of seedling development. Maximal expression is reached during week 3 after seed germination
+Expressed at early B-cell differentiation, in the developing CNS and in adult testis
+Expressed during early sporulation
+Expressed in oocytes at the late pachytene/diplotene stage and during the subsequent meiotic stages (PubMed:16273096, PubMed:25919583). Expressed in polar bodies (PubMed:25919583). Expressed at low levels in embryos (PubMed:16273096, PubMed:25919583)
+Expressed in all stages of embryonic and larval development as well as in pupae and adults
+During embryogenesis, expressed in HSN motor neurons (at protein level) (PubMed:10049362). Expressed in HSNs both before and during cell migration (at protein level) (PubMed:10049362)
+Strict spatial and temporal transcriptional activation leading to a specific expression in the male germline cells; this specific expression pattern is dependent of the regulatory region of DUO1 (ROD1) 5'-YAACYGY-3' in its promoter (PubMed:15694308, PubMed:27624837). First observed in the germ cell during or soon after engulfment by the vegetative cell, just after asymmetric division. In maturating pollen, accumulates in germ cells before mitosis and remains high in mature sperm cells. Expression persists during pollen development (PubMed:19300502)
+Expression in the cochlea is stable from late embryonic stages to P12 (the onset of hearing in mice), but thereafter increases
+Slight reduction during senescence
+In mid instar larvae salivary glands levels are low during puff stage 1 and increase during puff stage 2 to become the predominant form in stage 3. Levels reach maximum in late larvae during puff stages 8-10, decreasing abruptly at stage 11. This expression pattern is also seen in Malpighian tubules and wing disk. Levels at puff stage 11 are appreciable in the gut and fat body. Transcripts are detected again in salivary glands from puff stages 12-14 and 17-21
+Expressed both maternally and zygotically. Zygotic expression is seen in third larval instar, pupae, and adults
+In 12.5 dpc and 13 dpc embryos, it is expressed in the central nervous system, e.g. in the neural tube, the dorsal root and the cranial ganglion
+Expressed in the 2-somite stage (10 hpf) in the neural keel between rhombomere 7 (r7) and the anterior spinal cord. Between the 2- and 20-somite stages (10-19 hpf), expressed caudally in the developing spinal cord. At 25 somite stage (21 hpf), detected throughout the spinal cord with expression levels gradually decreasing from anterior to posterior. At the prim-5 stage (24 hpf), detected in the pectoral fin buds and in the dorsal forebrain. At the long-pec stage (48 hpf), expressed in the telecephalon, tectum opticum, hindbrain, cerebellum, in the first pharyngeal arch, in the eyes and at very low level in the olfactory placodes. Around the protruding mouth stage (72-96 hpf), some expression is still detected in the eyes and only scattered expression is seen in the tectum, midbrain/hindbrain boundary and hindbrain. By the early larval stage (120 hpf), no expression is detected in the first pharyngeal arch and only low expression is detectable in the telecephalon, midbrain/hindbrain boundary, hindbrain and along the edges of the tectum
+Isoform 3 is expressed in fetal brain but not in other fetal tissues
+Levels do not vary in adipose tissue from epididymal fat pads between 3 weeks and 2 years of age (PubMed:1770312). In heart, levels are lowest in the fetus, increase rapidly within the first day postnatally, and then gradually increase to stable adult levels by 2 months that are 3-fold higher than observed in fetal rats (PubMed:1770312). Levels in the adrenals are lowest in fetal rats, increase 4-fold during the first day and peak at levels that are 9-fold higher by the end of the first week (PubMed:1770312). Thereafter, levels fall and remain 3-to 4-fold higher than at birth throughout adult life (PubMed:1770312). Undetectable in testis before 4 weeks of age and increase 25-fold to stable adult levels between 4 and 12 weeks (PubMed:1770312)
+Levels increase transiently after germination, before and during radicle emergence, especially in darkness (at protein level)
+Expressed during sporulation, in the late phase of coat protein synthesis
+Expressed during flower development with a peak just before anthesis
+Expressed between month 3 and month 4 of pregnancy
+Expression begins around the ventral closure stage of embryogenesis, continues throughout larval development and decreases in adulthood
+Expressed throughout development (PubMed:24569477). Expressed in stretches and puncta in the body syncytium and in puncta within seam cells (PubMed:26371552)
+Detected between 13.5 and 14.5 dpc in both female and male gonads (at protein level). Increases in the male gonads and intensely expressed before birth (at protein level). In female gonads, remains constant until birth (at protein level). In testis, specifically expressed in premeiotic germ cells (at protein level). In fetal ovary, expressed in both premeiotic germ cells, and germ cells that have gone through the pachytene phase and entered meiotic arrest (at protein level)
+Expressed during gastrulation in the ventral region of the embryo which includes tissue fated to form the non-neural ectoderm
+Expressed in both ASEL and ASER neurons throughout late embryonic and early larval stages
+Expressed uniformly throughout the embryo until 10.5 dpc. From 11.5 dpc, the relative expression level increases in the liver, hind brain, spinal cord, dorsal root ganglia, and the posterior commissure
+Accumulates at 10 day postpartum (dpp), when pre-leptotene/leptotene spermatocytes first appear and when H2B expression shows a drastic decrease. Replaces H2B by 18 dpp in spermatocytes. Also present in metaphase oocytes and in the female pronucleus at fertilization and is also rapidly incorporated into the male pronucleus
+Expressed at the tegumental level in the protoscolices
+Detected in articular cartilage from 8 weeks of age, but not at earlier stages (at protein level)
+Expressed at all developmental stages (PubMed:17531954). Highly expressed in the embryo and expressed at lower levels in L3-L4 larvae (PubMed:17531954)
+Highly expressed in the embryo (PubMed:17531954). Not expressed in L3-L4 larvae (PubMed:17531954)
+There is a marked sex difference (female >> male) in the cytosolic level of this protein. Not age-specific
+During flower development, first observed throughout the floral meristem. Later expressed in rapidly growing floral primordia. Detected to a lower extent in vegetative primordia. During flower development, first observed throughout the floral meristem. Expressed during ovule development (PubMed:25378179)
+Detected throughout development (PubMed:18632251, PubMed:20466645). Highest expression levels are found at 0 hours post-fertilization (hpf), probably due to perdurance of maternal transcripts (PubMed:20466645). Expression levels remain high at 6 hpf and decrease rapidly by 12 hpf, followed by a second moderate peak in expression at 24 hpf (PubMed:20466645). Ubiquitously expressed during early stages of development (PubMed:18632251, PubMed:20466645). At 16-24 hpf, mainly found in eye, brain and somites (PubMed:18632251, PubMed:20466645). At 30 hpf, has strongest expression in forebrain, cerebellum and hindbrain (PubMed:18632251)
+Maternally encoded. Expression decreases during larval stages then rises during mid-pupal metamorphosis
+Expressed in the early neural plate of embryos. Expressed at the mid- to late-primitive-streak at stage 3. Expressed at the neuronal plate including streams of neural creast cells until at least stage 14
+Present at low levels early in the fifth larval stadium, followed by a large increase in abundance prior to pupal ecdysis
+Higher expression in developing than in mature central nervous system with a maxima at postnatal day 4
+Isoform B is expressed during embryonic development
+Expressed maternally and throughout early developmental stages
+Expressed in anthers and pollen of unopened bud and opening flowers, but not in fully opened flowers
+Not detected in undifferentiated primary osteoblasts. Expression increases during differentiation and declines to much reduced levels in mature osteoblasts
+Expression is highly dynamic but mostly restricted to the nervous system. Outside the nervous system, expression is detected in the rostral-most somitomere of the presomitic mesoderm, at the times corresponding to the epithelialization that precedes somite formation. First detected in the brain and spinal cord of 12 PC embryos
+Highest expression in unfertilized eggs and early embryos
+Expressed during all stages of development; high in embryos, declined in larvae and pupae and high again in adults
+First detected at the forming joint surface from 15.5 dpc, after cavitation has begun. At later stages of morphogenesis, strong expression is observed in cartilage surface cells (superficial zone chondocytes) and in the newly forming synovium
+Detectable at early embryonic ages. Isoform 10 is highly expressed in developing spinal motor neurons and in developing cranial nerve nuclei. Expression is maintained only in both adult motor neurons and dorsal root ganglion neurons. Type IV isoforms are expressed in fetal brain
+Expressed in oocytes from metaphase I to metaphase II during oocyte maturation
+Expressed in adult chemosensory tissues and during several stages of development
+Scarcely expressed in early stages, restricted to the shoot apical meristem in 14-day-old seedlings and detected in all tissues in 28-day-old seedlings
+Expressed in several differentiated postmitotic neurons during embryogenesis, but not in neuroblasts (PubMed:26153233). Expressed in larvae and adults in sensory neurons ASK and OLQ, the SMB motor neurons, and the SAA neurons (PubMed:26153233)
+Is detected on days 10 through 18 of embryonic development. During gestation it is detected in meckels precartilage mesenchyme, the basis occipitus, rib mesenchymal condensations, primordial vertebral bodies, digital mesenchymal condensations in forefoot and hindfoot plates, the ependymal layer of the spinal cord, and the mesoderm of the gastrointestinal tract. Expression persists throughout gestation in developing bone and cartilage of the extremities, the ribs, and the vertebral bodies as well as the gastrointestinal tract mesoderm
+Expressed both maternally and zygotically. Zygotic expression first begins in 8-cell stage embryos, with expression increasing in blastocysts. In embryos, both cell layers of the blastocyst: the trophectoderm (TE) and the inner cell mass (ICM) show expression
+Not detectable in the earliest stages of glomerulogenesis, and not detected in the metanephric blastema or surrounding cortical interstitial cells. In later stages of glomerulogenesis, localized to epithelial cells transitioning from the early developing nephrons of the comma- and S-shaped stages to the visceral epithelial cells of differentiated glomeruli. In the developing pelvis, expressed at the basement membrane of immature collecting ducts and by presumptive fibroblastic cells in the interstitium
+Not expressed during very early stages of flower development, but detected when buds are still closed
+Expressed throughout the inflorescence meristem (IM) and early stages of floral primordia. In developing flowers, restricted to the innert hree whorls, speci fi cally in the petals, stamens, and carpels. Within the stamens, mostly detected in the anther locules as well as in the vascular strands. In carpels, mainly present in ovules
+Expressed during embryogenesis. Detected in the precursors of the columella root cells
+Most highly expressed in early embryos. Levels decline in later stages of development
+Expressed throughout development from embryo to adult stages (at protein level) (PubMed:28317021). In larvae, expressed at the neuromuscular junction both pre- and postsynaptically (at protein level) (PubMed:28317021)
+Transiently induced from 4 to 7 days after seed imbibition
+Expressed ubiquitously from 10.5 to 18.5 dpc
+Expressed during silique development, but limited to the carpels and the pedicel
+On early hematopoietic progenitor cells
+In flowers, present in stamen, petals and stigma
+Expressed maximally at the loose mound stage
+Expressed in growth cones of ventrotemporal (uncrossed) retinal ganglion cells that give rise to ipsilateral projections (at protein level) (PubMed:12971893, PubMed:18524895). In myogenic progenitor cells, initially expressed early during myogenic development (11.5 dpc), down-regulated during the fetal stage (lower levels at 17.5 dpc) to be re-expressed in postnatal satellite cells (PubMed:27446912)
+In seedlings, observed in the subapical region of primary roots, lateral root primordia, leaf veins and around guard cells (PubMed:27792779). In flowers, present in ovules, pollen, embryos and endosperm (PubMed:27792779)
+Mammalian stage of parasite
+Expressed during specific stages of spermatogenesis, with highest levels in stage 6-8 round spermatids after 3 weeks of age
+Ovarial and mature eggs, larvae and adult
+At 7.5 dpc, the protein is moderately expressed in embryonic ectoderm and weakly in mesodermal cells. At 8.5 dpc and 9.5 dpc, the expression become ubiquitous with an increase in the somites and in the ventral part of the embryo
+Expressed during the parasite blood stage, including in rings, trophozoites and schizonts (at protein level) (PubMed:14698441). Expression increases in trophozoites and schizonts (PubMed:14698441)
+In the embryo, expression is detected between days 6.5 and 14.5, particularly during neurulation. At embryonic days 11.5 to 12.5, expression is high in the interdigital regions destined to undergo apoptosis
+Shows little prenatal expression, with highest expression at postnatal day 21
+Expressed throughout oogenesis. Homogeneously distributed in stages I and II oocytes and only later localized primarily to the vegetal cortex. Expressed in early stage embryos, but expression decreases during gastrulation, reaching barely detectable levels by tailbud stages
+Expression levels are regulated during the cell cycle, reaching maximal levels at M phase and then rapidly declining after late M phase
+First expressed in the embryo and subsequently in larvae and adults
+Expressed in the entire otic vesicle at stage 9.5 dpc gradually restricted to the epithelium of the endolymphatic ducts at stage 16.5 dpc
+Highly expressed in developing salivary glands at 13 dpc, a stage of particularly active salivary gland branching. Concentrated around the bottom and lower sides of forming clefts, while it is weakly or not expressed in other salivary epithelial regions. Also expressed in mesenchyme containing high levels of fibronectin
+In developing testis, expression increases steadily until sexual maturity (approximately 49 days postpartum) where it remains expressed at a relatively constant level
+Expressed at all stages of developing embryo
+Expressed in both the apical and basal cell at the one-cell embryo stage and in all cells of the embryo and suspensor through the globular stage. Decreases in the periphery of the hypocotyl and on the abaxial side of cotyledons from the heart stage to the torpedo stage, and by the bent cotyledon stage, restricted to the vascular tissue and the shoot and root apical meristems
+Expressed within 6 hours after induction, reaches maximum levels after 48 hours and declines after 72 hours after induction
+During the reproductive phase, accumulates in immature buds and at the base of the floral organs, and in the receptacle, ovules, anther filaments, and stigma and style of open flowers. Later observed in sporogenous tissue of anthers. During male gametogenesis, expressed in the microspores before they separate from each other. Later present at high levels within pollen grains up to stage 13 of flower development, when anthers dehisce. During carpel development, first detected in developing ovules. After fertilization, confined to globular structures or nodules of proliferating free nuclear endosperm required for embryo development. Disappears from the endosperm at to the heart stage of embryo development, when very little nuclear endosperm remains. Never detected in developing embryos at any stage. In young seedlings, present everywhere except in a portion of the hypocotyl and in newly emerging leaves
+Expressed from day 9 of pregnant uterus. Highest level at day 12, specifically in the decidua and weakly, in the myometrium. Levels decline thereafter
+Accumulates steadily during G2 and is abruptly destroyed at mitosis. Expressed in spermatogonia and is most abundant in preleptotene spermatocytes, cells which will enter the meiotic pathway
+Up-regulated in embryonic stem cells upon retinoic acid-induced differentiation into embroid bodies (at protein level) (PubMed:28494942). No significant changes in mRNA levels between dividing and non-dividing cells, although levels tends to be slightly higher in non-dividing cells (PubMed:20154270, PubMed:24107381)
+First expressed in late 2-cell stage embryos at the anterior periphery of the P1 blastomere, where P1 contacts the AB blastomere (at protein level) (PubMed:8674418). Maternally expressed in newly fertilised eggs, and present in all blastomeres between 1-cell and 8-cell stages (PubMed:8674418). After the 8-cell stage, rapidly disappears from all somatic blastomeres, and then expressed in P3 blastomere at the 12 cell stage (PubMed:8674418). In 36-cell stage and later embryos, can be detected in one to five unidentified cells (PubMed:8674418). Expressed in the P6.p vulval precursor cell (VPC) during larval L3 stage, coinciding with extension and reflexing of the gonad (PubMed:14960273). Expressed in cells immediately adjacent to ventral mesodermal lineage (M lineage) cells, but not next to dorsal M lineage cells, beginning at the 4-M stage (PubMed:18036582). Expressed in the distal tip cell (DTC) starting in the larval L3 stage (PubMed:19502484). Expressed in the secondary vulval epithelial cells and the non-target vm1 cells at the larval L4 stage (PubMed:23539368)
+Expressed around the blastopore through gastrula stages. Expressed in the neural tube (posterior dorsal neuroectoderm and the posterior ventral ectoderm) at late neurula stage 20. Expressed in the posterior tip of the neural tube and the posterior wall of the neuroenteric canal at tail bud stage 30. Expressed in the developing gut at stage 40
+In the brain, expression is low at 11 dpc with higher levels detected in 15 dpc and postnatal brain. Expressed at low levels in adult brain
+Heat shock cognate proteins are expressed constitutively during normal development
+Expressed as early as 7.6 dpc. Expression remains high through 15.5 dpc
+Regulated in a cell cycle-dependent manner. Not expressed in the G1 phase. In G2, sequestered in the nucleus. Maximal levels seen at late G2/M phase and early prometaphase. Degraded at the metaphase-anaphase transition (at protein level)
+Expressed concomitant with the onset of mineralization in ossification centers of developing bone
+Accumulates specifically during spherulation
+In developing anthers, transiently localized to tapetum cells during early pollen wall formation, sporopollenin biosynthesis and sporopollenin deposition
+At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 6. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 2/somite 3 boundary, with expression decreasing towards the posterior
+In young pupae, expressed within 2 hours of infection and continued to accumulate over 16 hours
+Ubiquitous. Detected throughout embryonic and larval development and in adult hermaphrodites
+In the testis, expressed days 4,8, 14, and 35 of postnatal life with highest levels at day 35. In the brain, expressed in fetal stages and levels begin to rise after day 4 after birth and continue to increase through suckling and weaning reaching a peak at postnatal day 24. In the liver, expressed in fetal life from day 16-21 of gestation with a 3-fold increase in the four final days of gestation
+Expressed in adults
+Expressed in developing root hairs and elongating pollen tubes
+First detected at 0.5 days of embryonic development (at protein level). Detected at higher levels from 1 to 2.5 days of embryonic development (at protein level). First detected at 0.5 days of embryonic development. Levels increase strongly from 1 to 2.5 days of embryonic development
+Gradual increase in expression during development from embryo through to adult with highest levels of expression in the late larval and adult stages
+Expression is strongly enhanced in the gametes
+Expressed in endosperm 14 and 21 days after pollination
+There is a maternal contribution to the expression during the early stages of embryogenesis (PubMed:20805893). Zygotic expression is ubiquitous but reinforced in several embryonic tissues (PubMed:20805893). From stage 11 to 12, accumulates in the developing tracheal system, then in subsets of cells composing the central nervous system (PubMed:20805893). Finally, from stage-15, it is also strongly expressed in the gonads (PubMed:20805893)
+Expressed in embryo at 7 to 17 dpc
+Strongly expressed in vegetative shoot apex, young panicle, developing panicle, and the early developing florets
+Expressed during parasite asexual blood stages, specifically at the schizont stage and in free merozoites (at protein level)
+Expressed in stage VI oocytes; its levels clearly decrease after progesterone addition
+Expressed in differentiated myotomal muscle progenitors in embryos at 3 days of development (at protein level). Expressed in somites in embryos at 3 and 3.5 days of development. Expressed in the mesodermal core of the first and second branchial arches at 3 days of development. Expressed in forelimbs and hindlimbs at 3.5 days of development. Expressed in non-muscle territories including lens and otic vesicle at 3 days of development
+At the completion of differentiation and migration of granular cells and at the initiation of the formation of synapses in cerebellar neurons
+Expressed in migrating distal tip cells throughout larval development (at protein level)
+Weakly expressed in mesenchyme and parts of neural tube at 10.5 dpc. At 13.5 dpc, expressed in anterior part of neural tube, dorsal root ganglia, bilateral sympathetic trunk and heart
+First detected between 2 and 3 weeks after birth, in parallel with the onset and progression of meiosis
+Expressed in the developing heart at 13.5 and 16.5 dpc, during the transition from spongy to compact myocardium
+Present throughout the root, starting from the transition zone and including transition and elongation zones, but absent from the meristem
+Not detected in preadipocytes but strongly induced in mature adipocytes
+Expressed in anther tissues shortly after meiosis is completed and during the late developmental phases of siliques
+Levels relative to total cellular protein, increase as differentiation proceeds towards the final culminant. The levels of tri-methylation of Lys-5 (H3K4me3) diminish considerably during the process of differentiation. In contrast, the level of mono-methylation of Lys-5 (H3K4me1) becomes significantly enhanced during differentiation. There is a slight dip in di-methylation of Lys-5 (H3K4me2) around the time of aggregation and the level of this mark again dips during the final stages of spore formation. The levels of H3K4me1 and H3K4me2 rise during the inactivation of rasG that occurs after the onset of differentiation. The level of dimethylation at this locus peaks coinciding with the loss of H3K4me3. This enrichment of dimethyl H3K4 declines as the rise in the level of H3K4me1 continues. H3K79me2 (di-methylation of Lys-80) is expressed during the whole life cycle
+First detected at the neurula (stages 16-17). First peak of expression around tadpole hatching (stages 33-40). High expression observed in intestine at the climax of morphogenesis (stages 60-62) when intestine epithelial undergoes morphogenesis
+Highly expressed in fetal liver and at lower levels in fetal brain, heart, kidney, spleen and thymus
+Expressed constitutively at a low level in young seedlings and in roots, stems and leaves of mature plants
+Expressed only in the adult
+Maximally expressed during early aggregation
+Fetal ovary and fetal testis (at protein level)
+Detected at very low levels at 18 dpc and increased to its maximum level of expression by 7 days after birth in olfactory sensory neurons of the septal organ
+Not detected at 13.5 dpc. Detected in mitotically arrested gonocytes of 14.5 dpc embryos. From 17.5 dpc to newborn, it is expressed in some centrally located gonocytes and cells present at the periphery of the developing seminiferous tubules. Present in nuclei of spermatogonia from 15 days after birth to adulthood
+Expressed at 14.5 dpc in testis, kidney and bladder. Expression drops at 13.5 dpc in female gonads and is not detected at 15.5 dpc while it is expressed by Sertoli cells in testis
+Expressed throughout both the fourth and the fifth larval instars
+Expressed both maternally and zygotically. In oocytes, expression gradually decreases throughout successive oocyte stages. Expression is maintained up to the larval stage (stage 35). Not expressed in adults, with the exception of expression in the ovary and weak expression in the testis
+Strongly expressed in senescent leaves
+Expressed during the spore stage, in conidia, during germination, and weakly in hyphae (at protein level)
+Expression begins during primary neurogenesis at the neural plate stage (stage 12) and accumulates at the tailbud stage. Expressed after neurog2/X-ngnr-1 and before neurod1. Also expressed in adults
+Detected at 11.5 days post coitum (dpc) in developing brain, and continues to be expressed all the way through to postnatal day 21 (PubMed:23300874). In brain, expressed at 13.5 dpc in thalamus, hypothalamus, midbrain and pontine area (PubMed:16257534)
+Expressed throughout development from embryos to adults. Highly expressed in the nerve cord of embryos. Expressed in vulval epithelial cells of L4 stage hermaphrodites
+Expressed both maternally and zygotically. Expression is very low in late embryos, larvae, pupae and adult males
+Expression is high in the liver before weaning and very low in adult rats; the reverse developmental regulation is observed in the brain
+Expressed during the growth phase and early development. Levels start to decrease strongly after tight aggregates formation
+Expressed at 8.5 dpc and 10.5 dpc in the cerebral cortex; expression declines rapidly from this point
+Expressed in the intestinal epithelium of premetamorphic tadpoles. During intestinal metamorphosis, down-regulated in the apoptotic epithelium and concurrently up-regulated in the connective tissue but with little expression in the developing adult epithelium. Toward the end of metamorphosis, expressed in adult epithelial cells as they differentiate
+At embryonic day 19, both maternal and embryonic kidneys express isoform 1 almost exclusively. In the postpartum female and neonate, expression of isoform 2 increases
+Expression during embryogenesis increases between 7 dpc and 11 dpc. Levels of expression subsequently decrease and reach a steady-state level by 17 dpc
+Expressed during thymocyte maturation. Weakly expressed in CD4(-) CD8(-) thymocytes, strongly expressed in CD4(+) CD8(+) thymocytes, while expression decreases in more mature cells
+Expressed in the embryonic respiratory system, different epithelial structures and strongly in the spinal ganglia, during the development
+Not detected at birth and up to day 20. Intermediate levels were detected at day 40 and adult levels were reached at day 60
+Expressed during the parasite blood stage, specifically in schizonts, and gametocytes (at protein level)
+Expressed in vegetative cells only (at protein level)
+Expressed both maternally and zygotically. During gastrulation, expressed in the neuroectoderm. At the 3-somite stage, expressed in the prospective forebrain, hindbrain and tailbud. From the 5-somite stage, expressed in the somitic mesoderm. At the 16-somite stage, also expressed in the dorsal neural tube, the eye and the Kupffer's vesicle. At 48 hours-post-fertilization (hpf), expression continues in the dorsal diencephalon and cerebellum and is observed in the otic vesicle
+Expressed initially in the central region of the blastoderm embryo
+Expressed during the asexual blood stage, in schizonts (at protein level)
+Accumulates preferentially during asexual sporulation
+Expressed in larvae (at protein level)
+Expressed both maternally and zygotically. At the early gastrula stage, expressed mainly in the entire animal hemisphere. During neurulation, its expression becomes restricted to the anterior neuroectoderm. At the tailbud stage, expressed in various anterior regions including the anterior central nervous system (CNS), otic vesicles and branchial arches
+Not expressed maternally. Expressed throughout the neural plate at stage 13. Expressed in trigeminal ganglia at stage 20. Expressed in the spinal cord, hindbrain and ventral floor of the fore- and midbrain at early tailbud stages. Expressed throughout the CNS, including eyes, epiphyse, nasal pits, cranial ganglia and nerves at stage 38
+First detected in the testis at 5 weeks. Level of expression increases up to 7 weeks and maintains even at 63 weeks
+Levels are high during gestation, but decrease greatly towards the end of gestation
+Expressed throughout seedling growth
+Expression is detected in growing cells and decreases dramatically at the onset of development. The rnrB transcript reappears after the cells have formed multicellular aggregates
+In flowers, present in anthers central vascular strand of the filament and in connecting tissues of the pollen sacs. Also present at the silique attachment site of the pedicel
+First observed after seed germination, mainly in the root cap, and in elongation and maturation zones, and, to a lower extent, in the apical meristem zone. Later present in roots, with higher levels in light conditions than in darkness. Weak levels in young flowers. Progressive accumulation in developing siliques, at both ends. In rosette leaves, mainly localized in vascular tissues and hydathodes
+Maternal transcripts are deposited into the egg and uniformly distributed throughout the cortex of cleavage stage and syncytial blastoderm embryos. Zygotic transcription is first found in the ventral furrow primordium during the beginning of cellularization, about 30 min before the start of constrictions also expressed about 30 min before the start of constrictions in the posterior midgut primordium. The ventral-most cells are last to express fog
+Expression declines during flower maturation but increases during leaf maturation
+Increases during development from very low levels at embryonic day 10 and is most abundant after hatching
+During embryogenesis, specifically expressed in the precursor cells of the quiescent center (QC) at the heart, torpedo, bent-cotyledon, and mature embryo stages. At the seedling stage, expressed in the QC and vascular bundles of root differentiated zones and lateral root primordia. Expressed in the vasculature of hypocotyls, and meristemoids and guard cells of cotyledons
+Expressed at all stages including blood asexual stage, gametocytes, zygote, oocyst, ookinete and sporozoites
+In anthers, expressed from the meiosis stage to mitosis, with maximum levels at stages 7 and 8, when meiosis initiates, and when endothecium and the middle layer become condensed, respectively
+Isoform a and isoform b are expressed at all developmental stages examined, isoform a is more abundant at embryonic and early larval stages and isoform b at first larval instar
+Widely expressed in most postembryonic tissues, including epidermis, muscles, pharynx, intestine and neurons
+Detected throughout the spinal cord except in the ventricular zone surrounding the central canal, which contains proliferating neurons, and dorsal root ganglia at 11.5 dpc. At 12.5 dpc, detected in the telencephalon, and by 14.5 dpc a distinct laminar pattern of expression was seen in regions adjacent to the ventricular zone. In the developing eye, expression was detected in the inner nuclear layer of the retina beginning at 13.5 dpc
+Preferentially synthesized in cells of the early growth phase of Ehrlich ascites tumor
+Predominantly expressed in the eye during embryonic development
+First expressed at day 7.5, exclusively in the allantois. At day 8.5, expressed only in the sinous venosus of the developing heart. At day 9.5, expression observed in the forelimb bud, optic vesicle and sinous venosus. By day 12.5, expression is limited to the retina, the body wall and the mesenchyme of the lung, of the mandible and of that surrounding the trachea
+Found in developing embryos, microfilariae, third and fourth stage larvae and adults
+Detected in floral apices, young ovule primordia, and young anthers with immature pollen, but not in older anthers with mature pollen. After fertilization, expressed in globular embryos
+Expressed from day 21, around when spermiogenesis occurs (PubMed:34714330). Expression dramatically increases at the mid-round spermatid stage (steps 4-6) (PubMed:34714330)
+Highly expressed during sporulation
+Expressed in 1.5-fold stage embryos, in developing pharynx and at lower levels in hypodermal cells and the hindgut (at protein level)
+Embryo, between 4 hours and larval first instar whereupon expression is greatly reduced. Continued expression only in the CNS up until hatching
+Low levels throughout postembryonic development
+Expressed strongly during late embryogenesis and early larval development in three types of interneurons, the paired neurons AIB and RIB and the unpaired neuron RIS in the head, with the strongest expression in RIS. Expression after embryonic development decreases until the adult stage
+Accumulates in leaves and stems during flowering (PubMed:29872026). Highly expressed in capsules walls and contents after flowering (PubMed:29872026)
+Expressed in the apical region (growing zone) of the root hair. Expressed in the basal growing zone of air-grown internode
+Ubiquitously expressed from ES cells to midgestation
+Highly expressed in embryonic liver
+Expressed throughout flower development
+Mainly in fetal kidney and juvenile nephrogenic rests
+Induced during seed germination
+At the begin of fourth week of development detected in cytoplasm of somite cells, and at the end of fourth week is accumulated in the nucleus. Between the sixth and eighth week of development detected in the nucleus of limb bud cells
+In florets, detected in glumes, lemmas, paleas and anthers (PubMed:28585692). Also present in ovaries at various developmental stages (PubMed:28585692). Expressed in the mature embryo sac, which comprises four cell types: egg cell, central cell, synergids, and antipodal cells (PubMed:28585692). Observed throughout early embryogenesis and in the endosperm at both the free-nuclear and cellular endosperm stages (PubMed:28585692). In endosperm, confined progressively to aleurone layer (PubMed:28585692). Expressed in anther tapetum and microspores, as well as in the stigma of mature pistils (PubMed:28585692). In 12 days old seedling roots, detected mainly in the cortex and epidermis of the maturation zone, as well as in root hairs (PubMed:28585692). In stems, concentrated in the pith tissue in the middle of the stem (PubMed:28585692). In leaves, confined to mesophyll tissue (PubMed:28585692)
+Expressed at 12 dpc throughout the developing cortex with notable apical enrichment in radial glial cells (RGCs) along the ventricular surface
+Expressed early during flower development within petals, stamens, and carpels
+Detected at 3.5 dpc (at protein level). Activated during the process of germ cell specification at 7 dpc.25, specifically in the founder population of lineage-restricted primordial germ cells (PGCs). Thereafter, expressed in the germ line until about 15.5 dpc in male and 13.5 dpc in female gonads. Expressed during blastocyst, morula and 4-cell embryo stages
+Expressed first at the dermatogen stage of embryogenesis and then in all cells of the embryo and suspensor through the globular stage. Decreases in the periphery of the hypocotyl and on the abaxial side of cotyledons from the heart stage to the torpedo stage, and by the bent cotyledon stage, restricted to the vascular tissue and the shoot and root apical meristems
+Expressed at 11.5 dpc in presumptive macrophages concentrated in the liver and scattered throughout the embryonic mesenchyme. Expressed at 11.5 and 12.5 dpc in the developing eye and in the ganglia and processes of cranial and spinal nerves constituting the PNS
+Highly expressed in trypomastigotes and to a lesser extent in epimastigotes and amastigotes (at protein level)
+Cyst merozoites
+Highly expressed during seed development and germination
+Expressed in the visceral ganglia at the gonadal early development stage in both sexes. Expressed significantly higher in the female gonad of early development stage (stage 1) than the indifference stage (stage 0). Males have higher expression in stage 1 compared with stage 0. Expression levels decrease during the late development stage (stage 2) and ripe stage (stage 3). There are positive significant correlations between the levels of this protein and progesterone as well as this protein and testosterone throughout the gonadal maturation
+Expressed during the early stages of tuberization
+Expressed specifically in the endosperm cap before radicle emergence
+In the embryo, expressed from 5 dpc and levels increase strongly until 15 dpc
+In young seedlings, expressed in all tissues except in the root tip. Later accumulates in cotyledons, newly emerging leaves and the lower region of roots. In rosettes, predominantly observed in the main veins of leaves. In flowers, present in petals, pistils and in the ends of young siliques
+Expressed in lung at least from to 9.5 dpc to adulthood
+Expressed in the nascent hair cells of the developing ear as early as 1 day post fertilization (dpf), and expression in the inner ear continues throughout development. Expression is restricted to the upper hair cell layer of the neuroepithelium at 5 dpf
+Detected only after round spermatids are produced approximately at day 18
+Mainly expressed in the postpartum and adult testis. Predominantly expressed in the spermatocytes, as well as spermatogonia and round spermatids (at protein level). Expression increases during the first wave of the spermatogenesis
+First expressed at neurula stages
+Expression is cell cycle regulated. Expression increases at the G1/S-boundary. Expression decreases in late M phase, remains low during G(1) phase, and starts to accumulate at the onset of S phase
+Shows a differential expression level in the skeletal muscle, the expression in 65-day embryos being higher than other stages
+Expressed in embryo at 8, 12 and 30 hours post-fertilization (hpf)
+Expressed during the asexual blood stage (at protein level) (PubMed:19171150). Expressed in gametocytes (at protein level) (PubMed:19171150)
+Initially expressed in a myocardium-specific manner at 8.5-9 dpc and remains cardiac-restricted until day 12. Strongly expressed throughout heart in all stages examined. At 12.5 dpc expressed at low levels in non-cardiac striated muscles. By 14.5 dpc expressed at high levels in both cardiac and skeletal muscle, and also strongly expressed in striated muscles of tongue, thoracic and abdominal muscles, leg and diaphragm. The various isoforms are developmentally regulated in both skeletal and cardiac muscle. Isoform 5 and isoform 6, which are barely detectable during embryogenesis are up-regulated postnatally. In heart, isoform 3 is up-regulated developmentally, whereas the predominant isoform 1 is expressed throughout development and into adulthood. In skeletal muscle, the predominant isoform 2 is gradually replaced by isoform 4 postnatally
+Up-regulated during keratinocyte differentiation
+Expressed in the developing brain embryo. Expressed in the mesencephalon in the tectum at 12.5 dpc and in the inferior colliculus at 16.5 dpc until birth. Expressed in the telencephalon in the ventricular zone, cortical plate, ganglionic eminence and hippocampus from 14.5 to 18.5 dpc. Expressed in the rhombencephalon in the pontine nuclei and in the external granule layer of the cerebellum at 16.5 and 18.5 dpc
+Metacestode-specific
+Expressed in a cell cycle-dependent manner. Most abundant at the G1/S transition. Lower but constant level in the following phases
+Expressed during heart development in the proepicardial organ, migrating proepicardial strands, delaminated mesenchymal cells and vascular smooth muscle. Expressed in epithelial precursors of the cornea, lens and retina of the developing eye (at protein level). Expressed in the left ventricular segment of the tubular heart at stage 11. Expressed in the myotome, notochord and ventral half of the neuronal tube
+Expressed at all developmental stages
+Not detected in the spleen of 1-week old mice. Detected from 2-weeks onwards and thereafter levels increase and then from 12-weeks onwards levels decline
+Expressed in glucagon- and ghrelin-producing cells of the pancreas at 14.5 dpc. Expressed in each of the hormone-producing cells population of the pancreas, except somatostatin-producing cells at 16.5 dpc (at protein level). Expressed during embryonic development. Expressed in the earliest islet precursor cells of the pancreas at 9.5 dpc. Expressed in neuronal cells in the inner ear between 9.5 and 12.5 dpc. Expressed within the otic epithelium and among the delaminating cells migrating away from the ear to form sensory neurons at 10.5 dpc. Expressed in the upper blade of the nascent dentate gyrus at 16.5 dpc
+Detected in cranial ganglia at 9 dpc, and in dorsal root ganglia by 10.5 dpc. First detected in gut at 11.5 dpc, with a marked increase by 12.5 dpc. After birth, detected in myenteric and submucosal neurons innervating the distal ileum, colon and rectum
+Expression is limited to the developmental stages in which maturing conidiophores are present
+Expressed at high levels in eggs and adults, and at low levels in larva
+Expressed during sporulation, around the time of spore coat synthesis and assembly, in mother cell compartment
+Expression levels are low in surface mucous cells and manicotto gland cells of the foregut epithelium of pro-metamorphic tadpoles. During metamorphosis, expression levels rise markedly in proliferating adult epithelial primordia. In the adult stomach, expression was strongest in oxynticopeptic cells, but was also detected at a lower level in surface mucose cells
+Expressed from early larval stages through to adulthood
+Expressed at the ventricular zone and subventricular zone areas, in the tectum, frontal cortex, ganglionic eminence, dorsal thalamus, hippocampus and tegmentum of the embryonic brain from 12.5 to 14.5 dpc. Expressed in neural progenitor cells (at protein level). Expressed in the embryonic brain from 10.5 to 17.5 dpc. Expressed in the telencephalon, mesencephalon and rhombencephalon areas from 11.5 to 12.5 dpc. Expressed in the developing central nervous system (CNS), such as the frontal cortex, hypothalamus and ventricular zones along the IV ventricle and aquaeductus mesencephali at 13.5 dpc (PubMed:18614158)
+Clearly expressed during growth and development. Expression culminates at 8-12 hours of development and is still clearly detectable at 18 hours of development
+Expressed in fat body from the fifth larval instar through to the pupal stage (Ref.4, PubMed:26078299). Highest expression levels are found at the wandering stage which marks the transition from larva to pupa (Ref.4). Expression then declines during later pupal stages (Ref.4)
+Expressed in the presumptive midbrain of developing embryos from the six-somite stage. By 24 hours, expressed throughout the midbrain including the region of the presumptive tectum. At later stages, expressed in a graded fashion throughout the tectum
+First detected at 10.5 dpc with highest expression at 11.5 dpc. Expression decreases during later stages of development at 12.5 dpc and 14.5 dpc (at protein level)
+Expressed at low levels in nerve tissue, salivary gland, Malpighian tubule, trachea, midgut, fat body, integument and muscle from day 3, fifth instar naive larvae. Moderate levels expressed in fat body from the 4th instar larvae (day 0), 5th instar larvae (days 3 and 6), wandering larvae (day 6), and adults in the absence of infection. A moderate level of expression in the hemocytes of the naive larvae. Expression increases substantially in fat body and hemocytes after fifth instar larvae are challenged with bacterial cells (PubMed:18265434). Constitutive low expression in naive eggs, but up-regulated in them in response to bacteria. Expressed in 24 h (predorsal closure stage) eggs in extra-embryonic tissues (yolk and serosa) after bacterial challenge, but not in embryos (PubMed:14728663)
+Expression peaks at embryonic day 11 and persists into adulthood
+Expressed during the parasite blood stage, including in rings, trophozoites and schizonts (at protein level) (PubMed:14698441). Expressed in gametocytes (at protein level) (PubMed:14698441)
+First expressed at stage 8 in the paired lateral plate mesoderm that forms the primordia of the heart. At stages 10 and 11, expressed in the lateral regions of the developing heart tube. At stage 13, strongly expressed in the right side of the looping heart. At stage 15, expressed in rostral somites. At stage 20, expressed in heart, skeletal muscle and tongue
+Isoform ARPP-19 is highly expressed in the embryo and its levels decrease progressively as development proceeds. In contrast, isoform ARPP-16 appears in the brain at the end of the first postnatal week and increases to reach a plateau
+Expression is observed in spores, increases about two- to three-fold at 0.5 hour to 1 hour during spore germination, and then rapidly decreases. The mRNA is not detectable in vegetative cells or in early multicellular development on filters, but is present late during development, approximately at the time of sporulation
+Expressed at low levels in fetal heart, at moderate levels in neonate heart, and at high levels in adult heart
+Ubiquitously expressed during all stages of embryogenesis, but expression is low during the first few cell cycles (at protein level)
+Expression is high in larvae seeking food and is down-regulated in late embryos coinciding with the onset of the behavior of older larvae, including food aversion, hypermobility, and cooperative burrowing. In males, expression is increased by mating and reduced by sexual deprivation
+Meiosis-specific
+Expressed at embryonic stage 20 in the notchcord and weakly in the foor plate and persist until stage 29. Expressed in the motor neuron pool at stage 23. At stage 26 and 29 highly expressed in the ventrolateral neural tube and also in the roof plate
+Expressed during the asexual blood stage; expression is high in rings and young trophozoites, and low in mature trophozoites and schizonts
+Expressed early in petals development and decreases in fully opened flowers
+Expression begins during embryogenesis and persists in a small number of cells throughout larval development (at protein level) (PubMed:20335356). Expressed transiently in the postembryonic non-gonadal mesoderm (M lineage), first detected in M.dlp and M.drp as they begin to divide (PubMed:20335356)
+Detected at 6.25 to 7.5 dpc in primitive streak, proximal epiblast, visceral endoderm and at the junction between the embryonic and extraembryonic ectoderm, with higher levels in the posterior region (PubMed:10431240, PubMed:19841259). Detected in the ectoderm at forelimb buds at 9.5 dpc (PubMed:12569130). Detected in all outgrowing limbs and in ectoderm flanking the limbs at least till 11.5 dpc (PubMed:12569130). Highly expressed in embryos at 11.5 and 12.5 dpc, with very low expression levels before and after this period (PubMed:2162045)
+The protein complex disappears from the plasma at onset of hibernation and reappears as hibernation ceases
+At 18 dpc, expressed in the cerebellum
+Expressed in the insect stage (promastigote) but not in the mammalian host stage of the parasite life cycle
+Expressed at high level in early embryo. Expression gradually decreases and remains low in the larval stages. A mild increase is observed at metamorphosis, and this level remains constant in the adult phase
+Expressed at the transition to terminal stomatal differentiation, just before and after the symmetric division of stomatal differentiation, being confined to late-stage guard mother cells (GMC) and to young, still differentiating guard cells (PubMed:16155180, PubMed:24571519). Detected in unopened flower buds, at the bases of sepals, petals, and stamens and in the receptacle of carpels, as well as both in style and stigma. Present at strong levels in the placenta within the ovary. Accumulates during ovule development in a dynamic pattern; first observed at high levels in the funiculus once integument outgrowth has begun and persists into later stages. Also expressed in the nucellus of younger ovules, especially in the megaspore mother cell (MMC) and in epidermal cells. Present in integuments, in the endothelial layer and the outer layer of the outer integument, which will form the mucilage-containing seed coat cells (PubMed:22915737). In developing embryos, first detected in cells in the ground tissue meristem at the early heart stage accumulates in the torpedo stage. In mature embryos, expressed in the embryonic hypocotyl and root tip. In seedlings, present first in the lower part of the hypocotyl and in the root tip, and later in petioles of cotyledons, young leaves, and lateral root primordia, near the pericycle. In young plants, strongly expressed in petioles of young leaves and cotyledons, especially in veins, in the basal part of young first leaves and cotyledons, and in root tips of lateral roots. Detected in the phloem, as well as in the cortex of inflorescence stems (PubMed:26391711). In roots, present in the root tip in columella cells, specifically in the lower tier of columella cells, as well as in developing metaxylem (PubMed:26391711, PubMed:26578169). Widely expressed in freshly emerged lateral roots. In elongating lateral roots, confined at high levels transiently in columella cells until differentiation (PubMed:26578169). Expressed at the base of developing flowers, including ovaries. In flowers, detected in ovaries, receptacles, and transiently, in anthers, and, later, in filaments. Also detected in the valve margins and receptacles of siliques and at the joint between the stigma and the style, as well as in the tapetum around pollen grains in maturing anthers (PubMed:26391711)
+Expressed both maternally and zygotically. Levels decrease on oocyte maturation, increase during the midblastula transition, then decline again and are lost by 24 hours post-fertilization (hpf). Uniform distribution during gastrulation, but later becomes concentrated in mesodermal lineages, particularly those located ventrally
+Expressed in fetal brain and kidney. Lower expression in fetal liver and lung
+Up-regulated at days 4 and 5 after germination and during senescence
+Synthesized during the reproductive cycle
+Major secretory product synthesized by the conceptus during a very short period in early pregnancy
+Not detected in the embryo, observed in the intestine of early stage L1-L3 larvae, peaks at the L4 larval stage and declines in adulthood
+Expressed from 9.5 dpc. Expression is observed in the developing embryo, especially in the notochord, in developing skeletal muscles, and later in the ventricular zone of the nervous system
+Expressed in S phase and G2 phase
+Expressed in presumptive heart cells during dorsal closure
+Expressed in embryos, larvae and pupae at high levels with maximum expression in 6-12 hours embryos and 0-24 hours pupae (PubMed:8166882, PubMed:1394430, PubMed:1280560, PubMed:1340474). Low levels of expression are seen in adults (PubMed:8166882, PubMed:1394430)
+Most abundant at embryonic stage, its expression decreases dramatically during development
+Maternally derived transcript whose level of expression remains constant during early developmental stages or early gastrula. At tail-bud stage, transcripts are localized primarily to the neural and mesodermal tissues
+Expressed in fetal liver and brain
+Expressed in a cell cycle-specific manner in glioblastoma multiple cells. Low levels in G2/M cells increase with progression through G1 phase and entry and progression through S phase
+Expressed at the end of gastrulation (at protein level) (PubMed:24407481). Expressed in the embryo from 7 to 48 hours post-fertilization (hpf) (PubMed:17336905). Expressed in the axial mesoderm and its later derivative, the notochord at 11.5 hpf (PubMed:17336905). Expressed in the forming head and heart and in the posterior notochord at 18 hpf (PubMed:17336905)
+Activity is significantly higher in trophic forms than in cysts
+Expressed in the spermatogenic cells during early spermatogenesis (at protein level). Expressed postnatally from week 1 onwards with a slight increase in expression levels until week 3 (at protein level)
+Expression in the palate increases from 12.5 up to 15.5 dpc. At 14.5, detected in the nasal epithelium and detected in the medial edge epithelium. At 15.5 dpc, very strong expression in the nasal respiratory epithelium and epidermis, but not in the oral epithelium. In the nasal epithelium, limited to the respiratory, but not the olfactory, epithelium
+Not expressed in embryos. Expressed in larvae, pupae and adult males. Expressed during spermatogenesis
+Detected in the developing cortex at 9.5 dpc. Expression peaks between 10.5 and 13.5 dpc, remains robust at 15.5 dpc and declines thereafter. This peak corresponds to periods of active neurogenesis
+Isoform 1 and isoform 2 are expressed throughout development and in the adult. Isoform 1 predominates at each stage by about 5 to 10-fold
+Expressed at higher levels in the brains of scrapie-infected animals
+First expressed at 11 dpc in the rostral cluster of serotonergic neurons. During development, expression is restricted to serotonergic neurons located in the raphe nuclei
+Very low expression in eggs. Expression increases during the first and second instar larval stages, decreases in the third instar larval stage, increases again in pupae and decreases slightly in adults
+Expressed maternally. Expressed in the egg and early embryo at a constant level until the gastrula stage, declining drastically at the neurula stage
+High levels of PL10 during the meiotic and haploid stages of spermatogenesis
+Expressed in oscillating waves in hypodermal cells during the 4 larval stages and in adults
+Expressed both maternally and zygotically. Maternal expression is weak but still detectable at the blastula stage. Zygotic expression starts during gastrulation and progresses to strong expression at stages 30 and 45
+In roots, expressed in endodermal cells from the late elongation zones to the differentiation zone and, to a lower extent, in endodermal cells of the meristematic zone
+Highly expressed in green leaves but rapidly fades out during senescence
+In L1 larvae, expressed in vulval precursor cells (VPCs) and Pn.a-derived neurons. In L2 larvae, uniformly expressed in all VPCs. In L3 larvae, expression decreases in all VPCs except P6.p. In L4 larvae, expression decreases in descendants of P5.p, P6.p and P7.p while expression remains high in descendants of P3.p, P4.p and P8.p. In L4 larvae, expressed in the anchor cell and other cells in the somatic gonad
+Expressed in apical and basolateral ends of follicular epithelium during oogenesis (PubMed:8666669). In embryonic CNS, expression is seen in the neuropil, developing brain and neuronal cell bodies (PubMed:8666669). In embryonic PNS, expression is seen at the cell membrane (PubMed:8666669). In third instar larvae, eye imaginal disk expression is seen at the membranes of developing photoreceptors posterior to the morphogenetic furrow (PubMed:8666669). In pupal eyes, expression is at the membrane of cone cells, secondary and tertiary pigment cells, bristle precursor cells and rhabdomeres (PubMed:8666669). Expressed in the salivary glands of third instar larvae (at protein level) (PubMed:28554770)
+Maternally expressed. Expressed as early as the 1-cell stage and continued through the 8-cell and 32-cell stages and 15-hpf and 24-hpf stages
+Expressed in globular stage embryo 3 days after pollination (DAP) in a small region just below the center of the ventral portion of the embryo. At coleoptile stages, expressed in the corresponding region of the epiblast and the central part of the embryo, but weakly in the shoot apical meristem (SAM). At the shoot apex differentiation stage, expressed in the cells surrounding the provascular tissue and radicle primordia. In nearly mature embryos (6 DAP), expressed around the basal part of the provascular tissue and radicle, and around the shoot region at the base of the first leaf primordium, and the notch between the SAM and the second leaf primordium. Expressed uniformly in the inflorescence meristem, but after the transition from inflorescence to the floral phase, located specifically in the notches between the floral meristem and glume primordia. At later stages of flower development, uniformly expressed throughout the corpus of the meristem, and in the notches between glume primordia, but less well defined than in the previous stage
+Expressed in developing seeds from 3 to 9 days after anthesis
+Only expressed in adults
+Found in fetal liver and kidney
+In leaves, mostly expressed in vascular tissues and trichomes (PubMed:27006488). In flowers, accumulates mainly in sepals, stamen filaments, pollen grains and pistils, but barely detectable in petals (PubMed:27006488). Present in siliques at all stages of development (PubMed:27006488). During embroygenesis, expressed in both embryos and endosperms throughout embryonic development (PubMed:27006488)
+Expressed at all stages of development, with expression level decreasing from 7 to 11 dpc and more abundant levels of expression at 15 and 17 dpc. First detectable at relatively low level at 10.5 dpc in the area of the third and fourth branchial arches. At 13.5 dpc easily discernible expression seems primarily confined to the cartilage primordia of future bones. At 15.5 dpc expressed at the highest levels in skeletal elements in the interior non-ossified regions of cartilaginous structures and excluded from regions of ossification
+In the salivary glands, there is no expression in early larval stages with expression beginning 5-6 hours after hatching (PubMed:23624615). Maximum expression is reached about 24 hours after hatching, remains strong during the second and third instars and declines at the end of the third instar before the wandering stage (PubMed:23624615). No expression is detected at the wandering stage (PubMed:23624615)
+Expressed at high levels in early embryos (particularly at the 0-4 h stage), then low throughout the larval and pupal stages and in adult males (PubMed:10366721). Shows elevated levels in adult females (PubMed:10366721)
+Expressed in developing retinal progenitor cells at 12 dpc (PubMed:21875655). Developmentally regulated (PubMed:1678612, PubMed:1687503)
+Expressed continuously during the whole pregnancy with a peak during the first trimester
+Maximal level of accumulation during anthesis
+During plant development, expressed in the shoot and root meristematic regions, but not inthe meristems in seeds at germination nor in trichomes undergoing endoreduplication. During male gametogenesis, transiently expressed in immature pollen grains at the time of post-meiotic mitosis, but not in the female macrospores at any time of development. Expressed in the embryo sac after fertilization and the in the embryo proper and suspensor cells until the globular stage. At the triangular stage, expressed in the forming shoot apical meristem
+Restricted expression to the primary shoot in young seedlings. Later detected in hypocotyl, leaves and flowers
+Expressed in the brain throughout development, with expression first observable in the nascent diencephalon, olfactory bulbs and hypothalamus shortly after fertilization
+First expressed at early neurula stage (9-12 hours). Expression then increases greatly at the 16-somite stage, reached the maximum level at 36 hr of development, and thereafter decreased. Only expressed in adults in the brain
+During early pregnancy, low expression detected in uterus at 1 dpc
+Highly expressed in parasitic larvae (cercariae) and at a lower level in adults
+Expressed in fetal brain, and, to a lower extent, in fetal kidney
+In the intestinal epithelium, first expressed in undifferentiated and mesenchymal tissues, levels increasing by 12.5 dpc in the epithelial compartment. With epithelial differentiation at 15.5 dpc, Its expression increases substantially in the intervillus epithelium with lower levels in the mesenchyme. At later stages, expression continues in the intervillus epithelium. Also found at lower levels in the developing villi. In the developing brain, highest levels found between 11.5 and 13.5 dpc in the ventricular region. In the developing retina, it is expressed both in retinoblast and ganglion cell layers from 14.5 dpc to 6 days after birth. In other developing tissues, its expression is highest in the thymus. Also present in kidney, lung, liver, heart and chondrocytes. Weakly expressed in skeletal muscle and absent from choroid plexus
+Constitutively expressed throughout development (at protein level). Expressed more abundantly in the posterior prespore region of tipped aggregate, slugs and early culminants
+Expressed early during flower development
+Broadly expressed during the 11th week of gestation, with highest levels in the central nervous system, spinal ganglia, osteoblasts and osteocytes (at protein level)
+At 24 hours post-fertilization (hpf), expressed in the tail in a rostral-to-caudal gradient and more weakly expressed in the cerebellum and retina. At 48 hpf, strongly expressed at the boundary between the developing cerebellum and tectum and in the retina
+In seedlings, observed in the hypocotyls of both etiolated and light-grown plants (PubMed:26685188). Also expressed in the quiescent center and the maturation zone of primary roots (PubMed:26685188). Later present in cotyledons and the first pair of true leaves (PubMed:26685188). Accumulates strongly in mature rosette leaves (PubMed:26685188). Detected in the pollen of opened flowers (PubMed:26685188). Lower levels in dividing tissues (PubMed:26685188). Present in developed vascular tissues, stipules of true leaves, mature trichomes and guard cells (PubMed:26685188)
+At stage 8, faintly expressed in cranial ectoderm and in the somites. At stages 9-10, broadly expressed throughout the cranial ectoderm. By stages 11-12, more robust expression is detected in ectoderm adjacent to the hindbrain, including the otic placodes. Transiently expressed in the lens placode and ectoderm of the head at stages 13-15. Down-regulated in differentiating structures of older embryos
+Produced in the cephalic glands of both the nurse bee and the forager bee. This bee milk protein changes to alpha-glucosidase in accordance with the age-dependent role change of the worker bee
+Expressed in larvae and adult
+In leaves, mainly observed in starch-producing tissues including the mesophyll and the vascular companions cells. In flowers, detected in the stamens and pistil, as well as in the receptacle. Also expressed in the embryo
+Male specific. Maximum at 9 weeks and maintained in 9-month-old rats. Can be detected at low level in females up to 9-weeK-old rats but then decreases to undetectable level
+During ovule development, first expressed in the inner integument primordium and then on the abaxial side of the inner integument
+Expressed during conidiation
+Expressed during embryonic development and expression declines towards birth (at protein level). At 10.5 dpc, mainly expressed in the fore- and hindbrain, the snout, the branchial arches, the developing limb buds, and the tail. At 12.5 dpc, expression increased in the expanding fore- and hindbrain, as well as in the neural tract. Marked expression also observed in the snout, the interdigital mesenchyme of the limb buds, the tail, the branchial arches and somites, and the developing eye, tongue, heart and liver. Expressed in myoblasts and myotubes at 12.5 dpc (at protein level). From 12.5 to 15.5 dpc, expressed at the basal plasma cell membrane in the basal layer of the epidermis of the skin, lung and intestine (at protein level). Expressed in gonads at 12.5 and 14.5 dpc (at protein level). At 14.5 dpc in limb buds, becomes restricted to the future tendons. Expressed in germ cells at 16.5 dpc (at protein level). At 17.5 dpc, expression generally decreases, but remains high in the intestine, in the developing tubules of the kidney, and in the liver. Expressed until P12, although very low levels may remain in some tissues, such as intestines, kidney and brain, throughout adulthood. Following colonic injury, up-regulated in the wound mucosa at days 2 and 4 post-injury and down-regulated at day 6 post-injury, as compared with uninjured mucosa
+Expressed in leaf and panicles, but is down-regulated during natural leaf senescence, panicle development and pollination
+In the embryo, expressed from 6.5 dpc with highest levels found between 11.5 dpc and 13.5 dpc. At late stages of gestation, from 14.5 dpc, only low levels are detected
+In the developing cerebellum expression is decreasing in the first 3 postnatal weeks
+Expressed in both adult and embryo
+Expressed in the fat body of middle third-instar larvae
+Expression levels are low throughout larval stages and then increase in adults. Intestinal expression starts at the L1 larval stage, declines at the L2 larval stage and increases again in L4 larvae and adults. Highly expressed in the intestinal lumen of dauer larvae and, old and no longer self-fertile adults
+Accumulates in developing seeds 5 days after flowering (DAF)
+Expressed both maternally and zygotically. Expressed in embryos at a low level prior to the onset of zygotic transcription. Zygotically first expressed at stage 9, increasing to a plateau from stage 12 to 18, and decreasing to some extent after stage 25, although expression persists until at least stage 40
+Fetal ovary and fetal testis. Present in all germ cells of seminiferous tubules of the 24-week fetus (at protein level)
+Expression is seen at embryonic day 17 and is up-regulated developmentally with a correlation to neuronal differentiation
+Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome
+Expressed already by the time of neurulation. By 10.5 dpc, expression is abundant in the developing central and peripheral nervous systems. Major sites include the neuroepithelium of the fore-, mid-, and hindbrain, the spinal cord, the dorsal root, and cranial ganglia. In adult brain, expression is greatly diminished
+Expressed at all stages of development from embryogenesis to adulthood (PubMed:18234720). Expressed at all embryonic stages (PubMed:18234720)
+Expressed in the inner and outer pericarps of developing fruit at 20 days after flowering (DAF) (PubMed:21175894). Low expression detected at 49 DAF and gradually decreases up to 126 DAF (PubMed:21175894)
+Expressed in developing caryopsis at 1 to 5 days after flowering. Expressed exclusively in the pericarp at 5 days after flowering
+Specifically expressed during embryonic development
+Specifically expressed in adult tissues
+Expressed in the ventral embryonic node at developmental stage 8 dpc
+Expressed in embryonic brain from 10.5 to 17.5 dpc. Expressed in neocortical neural progenitors at the ventrical surface at 12.5 dpc (at protein level). Expressed in brain, heart, lung, liver, kidney, small intestine and limb at 16.5 dpc
+Expressed both maternally and zygotically. Expressed in all developmental stages; egg, embryo, larva, pupa and in both adult males and females
+Detected in non-diapause eggs through all stages of development. Detected only from 0-12 hours after oviposition in diapause eggs. Also expressed in diapause eggs following artificial diapause termination
+At embryonic stage 12.5 dpc, detected in a wide range of tissues including brain, heart, lung, cochlea, dorsal root ganglia, and liver (at protein level)
+Expressed throughout embryo development, with a slight decrease during endosperm development, and fades out during aleurone development
+Expressed in the developing retina
+First detected in very young embryos with as little as 48-64 cells
+Expression is first detected in oocytes of type 3A primary follicles (PubMed:14670992, PubMed:31118423). Transcripts accumulate during oogenesis (PubMed:14670992). Expressed in the cytoplasm of germinal vesicle oocytes before becoming concentrated in the subcortex of metaphase 2 oocytes (PubMed:28992324, PubMed:31118423). During meiotic maturation, the vast majority of the transcripts are degraded and virtually none is detected by 2-cell stage embryogenesis (PubMed:14670992, PubMed:18804437). The protein however persists during preimplantation up to the blastocyst stage (PubMed:14670992, PubMed:18804437). At 2-cell stage, excluded from cell-cell contact regions (PubMed:18804437). Continuous exclusion from these regions during preimplantation development leads to the absence of the protein from the inner cells of the morula and the inner cell mass of the blastocyst (PubMed:18804437). Expressed in ovaries at birth, expression peaks at postnatal day 10 (P10), expression is then decreased at P17 and further decreased at P21 (PubMed:10433232, PubMed:31575650)
+Detected in siliques from 3 days after pollination until maturity of seeds
+Expressed in all four whorls throughout flower development
+Detected in both larvae and adults
+Isoform 3 is expressed in larvae only. Isoform 4, isoform 5, isoform 6 and isoform 10 are expressed throughout development from embryos to adults
+Detectable in migrating neural crest cells during somitogenesis. At early larval stages, expression is visible in the ventricular zone, the upper and lower jaw and the developing pectoral fins. At later larval stages, expression fades out
+Regulated during development, with the highest level at postnatal days 10 to 14, suggesting a role in myelination of the peripheral nervous system
+Levels of this protein reach a maximum at embryonic day 16 and decline into adulthood
+Expressed only during the larval stage, the highest level is reached during the third larval instar
+Isoform 1 is detectable at all developmental stages starting from postnatal day 1. Isoform 2 is low at postnatal day 1, increases steadily until postnatal days 20-25 and then declines to an intermediate level
+Not expressed in etiolated leaves
+Expressed at low levels in quiescent cells. Expression rises upon entry into S-phase
+Expressed in developing thymus at 14 to 18 dpc, with maximal expression at 16 dpc
+Highly present in extravillous trophoblast cells, which are present at the placenta implantation site and invade the decidua and decidual vessels
+Only expressed during growth
+Expressed on the surface of developing seeds and from 8- to 16-cell stages to the heart stage of embryo development
+Expressed at low levels during hair follicle morphogenesis, with highest expression levels detected at late anagen stage of the hair follicle cycle (PubMed:11316781). Expressed in developing brain from embryo to adult (PubMed:16876275). In placenta, detected at 8 dpc, peaks at 10 dpc and declines thereafter (PubMed:10537154)
+Detected in all tissues of the developing embryos
+Expression is associated with the initiation of flower organs and ovules (PubMed:12699618, PubMed:18375658). Accumulates in the tissues of young seedlings but also in adult plants (PubMed:18375658, PubMed:21245040). In flowers, present in sepals, in the vasculature of petals, and in the filaments of the stamens and, at low levels, at the tips of the stigma (PubMed:18375658). In seedlings, observed in the vasculature of the cotyledons, hypocotyls, stems, and the first pair of leaves (PubMed:18375656, PubMed:21245040). Just prior to flowering, a strong reduction in expression levels occurs in the vasculature (PubMed:18375656)
+Expressed in young seedlings (PubMed:21245040). Later in development, confined to cells at attachment sites of organ to stems (PubMed:21245040)
+At 10.0 dpc, expressed in a band of primitive neuroepithelial cells in the neural tube, mesencephalon and telencephalon. At 11.5-13.5 dpc, expression is symmetrical, but tightly limited in areas of the forebrain, midbrain and hindbrain (PubMed:7619729). At 11 dpc, in the developing telencephalon, expressed at high levels in cells throughout the presumptive lateral ganglionic eminence (LGE), with an apparent ventral-to-dorsal gradient in expressing cell numbers. Positive cells are also scattered somewhat uniformly throughout the adjacent medial ganglionic eminence. At 12.5 dpc onward, exhibits a clear graded pattern of expression, with low levels found in cells located ventrally and the highest levels confined to those in the most dorsal portion of the LGE (at protein level) (PubMed:19709628). Expression decreases from 14.5 dpc on and becomes undetectable at 16.5 dpc (PubMed:7619729)
+During early pregnancy, moderate uterine expression is detected from 1 dpc to 5 dpc, with levels decreasing at 6 dpc
+Expressed at high levels in germinal vesicle-stage oocytes, as well as in zygotes and 2-cell embryos (at protein level). Drastically down-regulated after the 2-cell stage
+On embryonic days 15 (15 dpc) and 18 dpc, expressed in the cortical plate of the cerebrum. On postnatal days 0 (P0) and P7, a moderate expression is seen in the cerebral neocortex, hippocampal pyramidal and dentate granule cell layers. In the cerebellum, expressed in the cerebellar Purkinje cells. On P14, a decreased expression is seen throughout the brain. On P21, expression is seen in the cerebellar Purkinje cells, dentate granule cells and the hippocampal pyramidal cells
+Expressed in the notochord from the 10 somite stage. Highly expressed in head mesenchyme and developing cartilages that will form the craniofacial skeleton
+Induced at the marginal cells of the blastoderm at dome stage. During gastrulation stages, it is predominantly expressed in the extraembryonic yolk syncytial layer (YSL) with a dorsal-to-ventral gradient. Expression in the YSL is strongly detected just below the developing myocardial precursors and maintained throughout segmentation period. This expression continues through early somitogenesis. However, as somitogenesis proceeds, expression domains become evident in the somitic mesoderm and in the endoderm adjacent to the yolk extension. By 24 hpf, it is strongly expressed in a distinct compartment of the somites, in the endoderm, and in the heart
+Expressed both maternally and zygotically. Expressed throughout development, with a much stronger expression during larval stages
+Expressed during fruit ripening. Expressed at an extremely high level in fast growing tissues, such as young leaves and fruits
+Highly expressed in the yolk syncytial layer during embryonic (starting at the blastula stage) and early larval development, an extraembryonic structure implicated in embryonic and larval nutrition. Also observed in the deep cell layer during blastula stage, in numerous ectodermal derivatives after gastrulation, and after 3 days of development in a limited number of cells both in brain and in the eyes
+In mouse embryos, RALDH3 expression is first noticed in the ventral optic eminence at 8.75 dpc, then in the optic vesicle/cup, otic vesicle and olfactory placode/pit from 9.5 dpc to 11.5 dpc
+First detected in neural plate stage embryos within two domains. In anterior regions of the embryo, expression is detected within a zone at the midline of the neural plate while, in posterior regions, it is expressed in a bilaterally symmetric stripe that lies at the middle of the mediolateral axis. This pattern of expression is maintained throughout neural fold stages of development. Following neural tube closure, expression is maintained in posterior regions of the embryo at the midpoint of the dorsoventral axis of the neural tube. The expression domain apparent at the anterior midline of the neural plate, the presumptive ventral region of the neural tube, is not detectable following neural tube closure. At stages intermediate to stage 20 and stage 28, an anteroposterior striped pattern appears within anterior regions of the embryo. By stage 28, these stripes have coalesced to yield a uniform zone of expression. In anterior regions, expression is largely specific to the dorsal neural tube. Expression in more posterior regions of the embryo remains specific to the midpoint of the dorsoventral axis. This midpoint expression is restricted to the ventricular zone
+Highly expressed in immature dendritic cells (at protein level)
+Highly expressed in the brain at 15 dpc and 18 dpc. Expression gradually decreased as postnatal development proceeded. No expression detected in the liver, kidney, lung, thymus or spleen during all developmental stages
+Detected in stage 8 and stage 9 egg chambers (at protein level)
+Expressed in flower buds at stage 6 of development in tapetal cells and at stage 10 in the epidermal cells of growing petals and ovaries. In young siliques, expressed transiently in the inner integument of the ovules just prior to testal deposition
+Expressed at 7.5 dpc. At 8.5 dpc, expressed in telencephalon and somites. At 9.5 dpc, expressed in somites, forelimb bud, basal forebrain and first branchial arch. At 11.5 dpc, expressed in heart primordium and branchial arches
+Expression starts around 10.5 dpc. At 11.5 dpc, broadly expressed in the telencephalic and diencephalic vesicles. This pattern of expression continues until 17.5 dpc
+Expressed in the P lineage during embryogenesis (PubMed:18202375). Expressed at the 4- to 8-cell stage, and expression remains throughout the remaining P cell divisions in P2, P3 and P4 cells, and subsequently in primordial germ cells Z2 and Z3 (PubMed:18202375)
+Peak of expression 20 days after germination
+At least expressed from 17 dpc to 21 postnatal days
+Mainly expressed during embryonic development. Expressed in most tissues at embryonic day 11 with elevated expression in the developing central nervous system
+Expressed during vegetative development in young leaf primordia and at the base of the rosette leaves on the adaxial side. Expressed during reproductive development in young floral buds, and at the base of the sepals and petals
+Expressed in fifth instar larva (PubMed:19523068, PubMed:26780217, PubMed:27106120). In the silk gland, highest level on the first day of 5th instar larva, then displaying a decreasing trend daily. In the fat body, expression level is high in the early and late stages, and low in the middle stage of 5th instar larva (PubMed:26780217)
+During seed development, accumulates in the endosperm and in the developing embryo. Strongly expressed following germination throughout seedling growth, especially in aerial part. Present in cotyledons, including the vascular system, hydathodes and trichomes, as well as in young leaves and leaves primordia. In roots, mostly expressed 7 days after sowing. Localized in the central cylinder of roots and the lower hypocotyl area. Observed in the shoot apical meristem (SAM) and in the vascular system, particularly in the xylem parenchyma and phloem. During reproductive development, observed in flowers of stages 13-15, predominantly in the male reproductive tissues, mostly in the developing pollen grains, the anther tissues and the filaments, and, to a lower extent, in the vascular system of sepals and the gynoecium, and in petals. After fertilization, confined to the placenta and the abscission zone of the siliques
+From the second half of the larval final-instar, through the first two days of pupal development
+Expressed first in the fetal liver and then in lung and hematopoietic tissues
+Expressed in precellular embryo along the ventral midline and, in germ-band retraction embryos, in segmental stripes. Expressed in third instar larvae in imaginal disks, salivary gland, optic lobe, fat body, wreath cells and gastric caecae of the gut
+Expressed during growth-to-development stages with increase in cell density
+Expressed in many prospective brain structures of fetuses (at protein level). Highly expressed in the developing brain with higher expression in the ganglionic eminence, the amygdaloid complex, and the hippocampus. The expression declines in all brain structures in the final stages of gestation and in the neonatal period, such that it is already as low in infants as in adults
+Expressed in brain at 13.5 dpc. Expressed in brain, trigeminal ganglia and nasal epithelium at 18.5 dpc
+Expressed in oocytes, embryos and adults
+From fertilization until pre-globular embryo stage
+Expressed in the apical region (growing zone) of the root hair
+Expressed throughout development from 5 hours after egg laying though to adults
+Expression starts after gastrulation, when organogenesis has just begun
+Expressed after cells enter the multicellular phase upon starvation
+Expressed both maternally and zygotically. Expressed from early cleavage stage until blastula sphere stage. Expression is then barely detectable until the end of gastrulation (tailbud stage) when expression is resumed
+Expressed in embryos at 14.5 dpc
+Expressed predominantly in oocytes and one- to four-cell-stage embryos with weak expression in morula/blastocyst-stage embryos (at protein level). Expression increases from oocyte to the one-cell stage and then decreases toward the four-cell stage (at protein level). Highly expressed in oocytes of primary, secondary and antral follicles with low levels in oocytes of primordial follicles (at protein level)
+In the embryo, expression peaks during germ layer formation and early gastrulation
+Expression is seen in 11.5 dpc to 14.5 dpc embryos in four distinct regions of the ventricular zone in the developing spinal cord
+Isoform C is expressed both maternally and zygotically. Isoform A is expressed at the same level in adult females but at a much lower level in ovaries
+During germination, expressed in the embryo, vascular bundles and the root cap. In 6-day-old seedlings, expression in seed coat/endosperm disappears is detected only at the bases of the lateral root buds. Expressed in developing an mature siliques from 10 to 16 days after flowering (DAF)
+Expressed in early stages of floral development and switched off at maturation of the flower
+During stage 10 found in the anterior part of the visual system that later gives rise to the anterior lip of the optic lobe. At stage 12 also found in the posterior lip of the optic lobe. In third larval instar expressed in the optic lobe of the larval brain and in the eye antennal disk, both in antennal and eye portion
+Up-regulated during osteogenesis
+Down-regulated during differentiation to endoderm and mesoderm
+During the cell cycle, expression disappears during mitosis
+Expressed during the biotrophic phase of host-pathogen interaction
+Expressed in subepidermal cells of anlagen regions, then in abaxial part of primordia and finally in differentiating organs. Levels decrease in differentiated organs. In embryo the expression starts during the heart stage in the cotyledon anlagen. Later, expression expands to abaxial domain of the cotyledon primordia and decrease as the embryo matures. In stamen, expression restricted to the abaxial region differentiating into the connective. In gynoecium, expressed in the abaxial cell layers differentiating into the valves
+Expressed at low levels during vegetative growth, and accumulates dramatically by 4 hours of development. Expression levels remain high through 12 hours, and drop off at 16 hours
+Up-regulated during senescence, but not during the G0 to S phase transition
+Eggs and larvae
+First detectable in day 9 embryos, in the endocardium and vascular endothelium in the anterior part of the embryo. Expression in endothelial cells, initially restricted to aorta, omphalomesenteric and umbilical arteries, later extends to subcardinal veins, intersomitic arteries and perineural vessels. On day 10, detectable in the entire embryo
+Expressed in 30 days old embryos. Almost undetectable in 60 days old embryos and in adults
+Expressed at 60 dpc
+In a 7-week embryo, expressed in the urogenital sinus, the precursor of the bladder, and its outflow tract. The most prominent expression is in the primitive urothelium, and there is weaker expression in the surrounding mesenchyme. Expression also detected in the urothelium of the adult male urethra
+Expressed during larval stages and at a lower level in pupae
+Appears 12 days before anthesis and maximum levels are seen in pollen on the day of anthesis
+Expressed after tetrad release, until the end of the second pollen mitosis. Expressed in buds over 3 mm in length, maximum expression is observed in 3-4 mm buds and decreases rapidly in buds containing mature pollen
+Expression increases after germination and again in the mature plant
+Expressed maternally. Expression decreases suddenly at the gastrula stage
+Initially expressed in the testis at day 16 and reaches adult expression levels by day 30 after birth
+Expressed widely throughout development (at protein level) (PubMed:11203704). Earliest expression at the embryonic comma stage; expressed in the developing pharynx, hypodermal cells, hindgut lining, and also in several cells near the rectum and in the tail (at protein level) (PubMed:11203704, PubMed:15581870). Expressed in pharynx until adulthood, when it becomes undetectable (at protein level) (PubMed:11203704). Expression in adult hermaphrodites may be highest in the germ line (PubMed:11203704)
+Developmentally regulated. Expressed prominently in the thymus and specific regions of the brain, and more weakly expressed in the gut. In adults, highly expressed in the thymus and intestine
+In roots, accumulates progressively to reach a peak in 4-5 years old plants and later declining slowly in older plants
+Expressed maximally during postgerminative growth
+Expression varies across the cell cycle, with high levels in G2 phase (at the mRNA level)
+Expressed at a stable level throughout development
+Expressed shortly after the beginning of sporulation
+Confined to the midveins of petioles and leaf blades (PubMed:29258424). In flowers, only expressed in the filaments and stigma papillae (PubMed:29258424)
+Expressed both maternally and zygotically during developmental periods of maximal cell division; most abundant in early embryos and low levels in larvae, pupae and adults
+Expressed in globular stage embryo 3 days after pollination (DAP) in a small region just below the center of the ventral portion of the embryo. At coleoptile stages, expressed in the corresponding region of the epiblast and the central part of the embryo, but weakly in the shoot apical meristem (SAM). At the shoot apex differentiation stage, expressed in the cells surrounding the provascular tissue and radicle primordia. In nearly mature embryos (6 DAP), expressed around the basal part of the provascular tissue and radicle, and around the shoot region at the base of the first leaf primordium and the notch between the SAM and the second leaf primordium. Expressed uniformly in the inflorescence meristem, but after the transition from inflorescence to the floral phase, located specifically in the notches between the floral meristem and glume primordia. At later stages of flower development, uniformly expressed throughout the corpus of the meristem, and in the notches between glume primordia but less well defined than in the previous stage
+Accumulates during the desiccation phase of embryo development
+Peak of expression in seeds during maturation
+Expressed maternally throughout the embryo at the syncytial cleavage divisions and zygotically at the termini and in a broad central band during cellularization. At germ band extension, the protein is found in the mesoderm. Expressed in a subset of neurons from larva and pupa
+Very highly expressed in spores (PubMed:31655558). Expression is higher in fruiting bodies than in primordia, and low in mycelia (PubMed:31655558). In the fruiting body, present in the stipe, cap, gill and pileipellis (PubMed:31655558)
+Expressed during early embryo development and fades during differentiation
+Protein levels increase during G1 and S phases to decline as cells progress through G2 to enter in G1 phase of the next cell cycle
+Expressed both maternally and zygotically throughout early development. Maternal expression declines gradually by the early gastrula stage (stage 10). Zygotic expression increases by late gastrula stage (stage 12) with strong expression from the midneurula stage (stage 15) onward
+Expressed during embryonal and placental development
+Expressed both maternally and zygotically. Up-regulated in the neural ectoderm after the mid-gastrula stage
+Operon expression begins by 6 hours after starvation has initiated development and is under strong negative autoregulation
+Expression begins about half a month before the start of the spawning season (early December), and continues throughout the spawning season
+Expressed in all tissues (cotyledon, hypocotyls and roots) at uniform levels at all stages of development
+The expression pattern is very dynamic and is developmentally regulated
+Expression in the ventricular zone which corresponds to dividing neuronal precursors begins at day 12.5, increases during embryonic development and persists at postnatal day 7 (P7) in the ependymal layer, which is the remnant of the ventricular zone. Weak expression seen in the spinal cord and medulla oblongata, starting at 14.5 dpc and expression also observed in dorsal root ganglia, starting at 14.5 dpc. At P14, expression in the dorsal root ganglia is restricted to the cortical region where the sensory neuron cell bodies are located. In non-neural tissues strong expression seen in the developing liver from 10.5 dpc. Expression detected in the heart and in the cortex of the developing kidney at 12.5 dpc and later. Very high expression observed in the brown adipose tissue. Expression seen in small islands around the neck and back at 14.5 dpc, then in large masses at 16.5 dpc and 18.5 dpc and at P14 is absent in brown adipose tissue. Expression also seen in the thymus and developing gut at 14.5 dpc and until postnatal life. At P14, expression in thymus is restricted to the proliferating cells in the cortical zone and is also prominent in the spleen. Found in the lung at 14.5 dpc
+Expression at 3-6 hours of embryogenesis. Strong re-expression in first-instar larvae
+Expressed and spliced only during meiosis dependent on the splicing factor MER1
+Expression initiates during mid-embryogenesis primarily in post-proliferative hypodermal cells and neurons in the head, ventral cord and tail, then declines until hatching where it is mainly seen in seam cells. Expressed throughout larval development in several blast cell linages. In the P lineage, expression is restricted to proliferating cells, whereas it persists in somatic gonads and seam cells. In somatic gonads, expression is restricted to the spermathecal cells and their precursors. Not expressed in the intestine
+Most abundantly expressed during the early globular to early cotyledonary stages of embryo development
+Isoform 1 is detected 10 days after birth, and increased in a coordinate fashion during the development of brain, and the amount did not decrease when myelination was completed
+Strongly expressed in pollen and anther tapetum at later stages of pollen development, from post-meiotic pollen, in mature pollen and after pollen release (Ref.6). In roots, observed during root hair development (PubMed:20943851)
+Expressed in the vasculature, especially in phloem and procambium regions, from the mature embryo stage through the adult plant (PubMed:21853254). Excluded from early stages of lateral root development (PubMed:27296247)
+Expressed in intermediate to anterior presomitic mesoderm
+Activity increases as seeds develop
+In chemotaxing cells, is on the plasma membrane along the lateral sides and posterior of the cell but is absent or the level is significantly reduced at the leading edge
+During the reproductive phase, accumulates in immature buds and at the base of the floral organs, and in the receptacle, ovules, anther filaments, and stigma and style of open flowers. Accumulates before fertilization in the cytoplasm in the cells of the egg apparatus and moves into the nucleus during early stages of development following fertilization in the suspensor, embryo, and endosperm, mainly double fertilization derived tissues (at protein level). Highly expressed in developing embryos. In young seedlings, present in the shoot and root apices, lateral root primordia and throughout the vascular system
+Expressed maternally in stage 1-3 blastoderm embryos
+At postnatal stage P1 and P10, expressed in the brain, including the hippocampus, thalamus, striatum and substantia nigra. Highest levels in the hippocampus and thalamus
+First appears at the end of gastrulation in the axial mesoderm. By the 5-somite stage, expressed in telencephalon and anterior diencephalon. From early segmentation stages until the end of tail elongation, found in the tail bud. Expression is maintained during somitogenesis. At the 10-somite stage, detected in the antero-medial aspect of the somites. At 20 hours of development expression is observed in the ventro-medial part of the somite as well as in a small population of cells located more dorsally, adjacent to the neural tube. As development proceeds, expression in the dorsal somite is progressively lost, while ventro-medial sclerotomal cells lining the developing axial vasculature continue to show expression until 30 hours of development. In the head, expression is maintained in the telencephalon and anterior diencephalon until late embryogenesis. At the 15-somite stage, expressed in the forebrain, dorsal hindbrain and dorsal caudal spinal cord. Until late stages of embryogenesis strong expression is observed in the dorsal hindbrain walls
+Expressed in the developing brain. Expressed in the developing cortical plate at 11 and 14 dpc. Expressed in multipolar cells at 14 dpc (at protein level). Expressed in the developing cortical plate of the telencephalon (PubMed:23864681)
+Transcript levels remain constant in all phases of the cell cycle. In contrast, protein levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is reached, residual expression is observed in the G2/M and early G1 phases
+Up-regulated in the heart from 10.5 dpc to neonates and further increased in adults. Down-regulated in aged hearts (at protein level)
+Not detectable in testis from 6 day old animals. Detectable in testis 15 days after birth. Highly expressed in testis 20 days after birth. Highly expressed in meiotic and post-meiotic germ cells
+Expressed in erythroid cells in the vessels at 9.5 and 10.5 dpc (at protein level). Expressed in embryo at 7.5 dpc and in the yolk sac at 10.5 dpc. Expressed in the heart and yolk sac mesoderm at 8.5 dpc. Expressed in the head mesenchyme, somitic mesoderm, otic vesicle, vessels and few blood cells at 9.5 to 11.5 dpc
+Developmentally regulated. Expressed only during conidiation and early germination
+Expressed in floral meristems and sex organ primordia at early stages of development. Later expressed in anthers, particularly in the tapetum, pollen mother cells, and microspores
+Expressed at all stages of thymocyte development, with relative peaks at the DN3 and DP stages
+Expressed throughout all developmental stages
+Expressed during all stages of development and peaks in late larval and pupal stages. Expressed in both male and female adults
+Expressed zygotically in embryos from 0 to 12 hours after fertilization, with a peak of expression during the 2 to 4 hour period. Expression reappears in third instar larvae and pupae
+Expressed initially broadly in the definitive endoderm after gastrulation, becomes restricted to the gut and pancreatic bud at mid gestation, and is reactivated by Neurog3 in islet progenitor cells and is ultimately restricted to pancreatic islets in the mature pancreas (at protein level)
+First expressed at mid-late gastrulation within the dorsal ectoderm. By the completion of gastrulation its expression is clearly restricted to 3 groups of cells arranged in a radially symmetrical pattern on either side of the dorsal midline of the posterior neural plate, where the ventral, intermediate and dorsal groups of cells differentiate into motor neurons, interneurons and sensory neurons respectively. The same pattern of expression is maintained in later-stage neurula embryos
+Highest expression observed at the fetal stage. Expressed by smooth-muscle cells in the artery wall in a PDGF-dependent way
+Expression is elevated in spermatocytes, this expression is maintained high in the round spermatids with a decreased in elongated spermatid
+Maximally expressed before mitosis. The levels peak late in the G2 phase of the cell cycle and are at a minimum in G1 phase
+Expressed in inflorescence meristem during flower development at least until stage 6 of development
+Expressed at about stage III of sporulation. Specifically enriched in stage IV forespores but not in stage IV mother cells (PubMed:3933484, PubMed:3080407)
+Expression in the brain gradually increases during the first postnatal week, reaching a peak at P7. In the gray matter, highly expressed in both developing and adult brain. In the white matter, at P6 highly expressed in all major fiber tracts, including the anterior commissure and the corpus callosum, as well as the external and internal capsules, while in the adult, axonal expression in fiber tracts is only faint (at protein level)
+Expressed throughout life. Expressed in embryos, first- and third-instar larvae, late pupae and adults
+Isoform 2 is detected at high level in adult testis and at lower level in 19-day testis. Not detected in 14-day testis (at protein level). In the developing postnatal gonad, it is not expressed in 6-day-old testes in which the germ cells are almost exclusively spermatogonia or 14-day testis in which the most advanced germ cells are early pachytene spermatocytes. However, it is expressed in 21-day testis tubules containing late pachytene spermatocytes or spermatids. In the postnatal male testis, it is strictly confined to late pachytene spermatocytes through spermatids, a time during which meiosis takes place
+Undetectable during the perinatal period. During development, expression appears after the weaning of the young rat and reaches a maximal expression at the adult stage
+Detected in early embryonic stage as early as 15 dpc, gradually increased throughout early development, peaked at approximately between postnatal days P6 and P8, then slightly decreased and remained relatively stable in the adult
+Poorly expressed in vegetative cells. Well detected in migrating slugs and highly induced at the finger stage, reaching a peak level at 16 hours of development, and then decreasing to a very low level at 20 hours
+Expressed at 15 dpc. Expression is maintained until postnatal day 10 and decreases in adults
+Expressed prior to the formation of distinct motor axon pathways and before the segregation of motor neurons into columns. Expression is confined to the motor neurons in the lateral subdivision of the lateral motor column (LMC)
+Already expressed in the smallest stage I oocytes. Then it decreases during oocyte growth until stage VI (at protein level)
+Expressed in the mother cell at intermediate stages of sporulation under the control of the sigma-E factor
+Up-regulated during leaf development
+Not detected in the embryo, but accumulates upon germination of the seed and during seedling development
+Highly expressed at the mound and the culmination stages
+Expressed during spore germination. Seems to be present at the time of sporulation
+Peak of expression 2 days after germination. High levels of expression when aerial parts are growing
+Expressed in the embryo (beginning at the blastoderm stage), and in the larva
+Throughout development with lowest levels in first larval instar and late pupae
+Up-regulated in differentiating osteoclasts
+Induced in the early inflorescence meristem (PubMed:22319055). First present when floral induction occurs in inflorescence and floral meristems. Strongly expressed upon flower induction in inflorescence meristems along two lateral strips on the L3 of the flank meristem, where flower primordia are initiated. In the L3 of the central initiation zone, also present at lower levels. Accumulates at high levels in the L3 of stages 1-4 of flower meristems. In developing flowers, detected from stage 3. By stages 7 and 8, specifically observed in stamen and gynoecium primordia. In stamens, restricted to the anthers, probably to the endothecium, tapetum and the middle layer. In carpels, first uniformly expressed in carpel primordia, but later restricted to the placentae, the funiculus and to the inner and outer integuments (Ref.7, PubMed:22319055)
+At embryonic days 12 and 15, it is strongly expressed in the ventricular and intermediate zones of the brain and of the spinal cord. At postnatal day 10, it is detected in the dentate gyrus, the hippocampus, the cerebellum and the olfactory bulb
+Expressed primarily in the fetal brain, with low expression in the lung, and kidney at 6-7 weeks dpc (PubMed:8666406, PubMed:24886874). Weak expression in the fetal heart and muscle (PubMed:24886874)
+Expressed in the embryonic heart. Expressed in the left lateral plate mesoderm and symmetrically in the head mesoderm at 8.5 dpc. Isoform Ptx2c is expressed in the ventral outflow tract region (OFT), right ventricle (RV) and in the left atrium of the heart
+Detected as early as 8.25 dpc in the ventral neural tube. From 9.5 dpc to 11.5 dpc is expressed in the floor plate and motor columns. This pattern of expression continued until at least 17.5 dpc and remained weak. Rostrally, at 8.25 dpc is expressed in the ventral midline of the neural groove and in the neural fold prior to closure of the neural tube. Between 8.5 dpc and 9.5 dpc, expression is observed in the ventral side of the mesencephalon and metencephalon and in the commissural plate after closure of the neural tube. After 13.5 dpc, the expression of SLIT3 is weak in the developing CNS. At 9.5 dpc, SLIT3 is detected in the otic vesicle and in the clefts between the first and the second branchial arches. Between 10.5 dpc and 11.5 dpc is prominently expressed in the otic vesicle but decreased in the branchial clefts. From 13.5 dpc to 17.5 dpc, expression is observed in the cochlea, in the pigment layer of the retina, and in the olfactory epithelium. At 13.5 dpc expression is observed in the whisker follicle surrounding the bulb and shaft. In the developing limb is first detected at 10.5 dpc in distal limb bud mesenchyme. At this stage, is also observed in lateral ridge tissue flanking the limb bud. This pattern persisted through 11.5 dpc but unlike with SLIT2, expression is not observed in the inter-limb bud lateral ridge tissue. At 11.5 dpc, expression in both the fore- and the hindlimb is most intense in the distal anterior mesenchyme and in the proximal posterior cleft between the limb bud and the lateral ridge. At 13.5 dpc could be detected in the wrist and weakly in palm and proximal part of the digits excluding the tips of the digits
+Highly expressed in the nervous system of developing embryos. Also expressed in fetal heart, liver and kidney
+Decrease in mRNA levels during postnatal development
+Expressed throughout development but appears to be up-regulated in adults
+HOXD genes are coordinately expressed in partially overlapping domains during wing development
+Expressed throughout lifespan; expressed at low levels in single cells but increased during multicellular development, peaking at 10 h
+Expressed 75 minutes after bacterial infection. Increased dramatically after 6 hours, continued to increase through to 24 hours and is maintained at high levels until at least 30 hours after bacterial infection
+Abundantly and specifically expressed in the floor plate region of the spinal cord at embryonic day 13 (13 dpc) and 15 dpc and at lower levels at postnatal day 1 (P1). A high level expression was also observed in the ventral hindbrain and midbrain. No expression was seen in the notochord at these stages. Prominent expression in the nervous system was also seen in the choroid plexus. At 13 dpc, expression was also seen in the dorsomedial forebrain and roof of the hind brain. Robust and specific expression was detected in the choroid plexus epithelium of the lateral, 3rd and 4th ventricles at 15 dpc and P1 and persisted into adulthood. In the CNS, expression was detected in thalamic and hypothalamic regions at 13 dpc, 15 dpc and P1. In embryos, it was highly expressed in the limb buds, face region, large blood vessels, olfactory pits and pleural epithelium. In particular, expression was robust and specific in bone-forming regions of the face and in the mesenchymal cells surrounding the developing cartilages of the extremities
+Expressed both maternally and zygotically throughout embryogenesis, declines during larval stages and reappears during pupation
+Expressed in puncta in dorsal D (DD) motor neurons and in adjacent DA and DB cholinergic motor neurons in the larval stage L1 ventral nerve cord
+Expressed between 7 and 28 days after pollination
+Ubiquitously expressed in 8.5 dpc and 9.5 dpc embryos (PubMed:9771705). During embryogenesis, expressed at high levels in non-neuronal and differentiated peripheral nervous tissues, but is not expressed in differentiating neurons in the CNS (PubMed:7697725, PubMed:7871435). Expressed in the neocortex at embryonic stage 14.5 dpc and 16 dpc and in the utricle at 15.5 dpc (PubMed:29961578). Isoform 2: Expressed in the neocortex at embryonic stage 14.5 dpc and 16 dpc and in the utricle and saccule at 16 dpc (PubMed:29961578)
+Expressed during differentiation of squamous cells
+Specifically expressed at the late developmental stages in the cochlea
+Within siliques, accumulates strongly in developing embryos in the mid-stages of embryo development, during the time of abundant glycerolipid biosynthesis. In stems, confined to phloem and xylem. In flowers, mostly restricted to anthers (and more specifically pollen), and barely in sepals and petals
+First expressed in the m8 pharyngeal muscle cell and in ventral head neurons in embryos 400 minutes after the first cell cleavage
+Accumulates in floral buds, flowers, developing embryos during an early stage of silique development
+Expressed from 9.5 dpc
+Expressed at its highest level between 21 and 25 days, during the inflorescence stem elongation phase
+Expression increases in endothelial cells undergoing capillary morphogenesis
+Expressed throughout development from embryo to adult
+Maternally and zygotically expressed
+Highly expressed in cell walls of developing fibers at the early secondary walled stage of both phloem/cambium and xylem vascular tissues. Not expressed at later stages of secondary wall formation. Expressed in the innermost secondary wall layers of the developing phloem fibers. Expressed in the nacreous walls of developing phloem sieve tubes in the secondary phloem, and more weakly in both fusiform and ray initials of the cambium. Expression in expanding xylem cells is weaker than in the cambium, and developing vessel elements have weaker expression than expanding fibers (at protein level) (PubMed:12468728). Expressed in developing gelatinous (G) cell wall layer of the tension wood fibers (at protein level) (PubMed:17504814). Transiently expressed in developing leaves (PubMed:12468728)
+At 9.5 dpc, it is predominantly detected in cardiomyocyte nuclei This expression is maintained throughout embryonic development in the atria and in the ventricular walls and trabeculae. Also present in the outflow tract, the truncus arteriosus, the developing atrioventricular valve and the cushion mesenchyme. Appears to decrease after 14 dpc and by 17.5 dpc; it is then spatially redistributed, with highest levels in subendocardial myocytes and the septum and no expression in epicardial and apical myocytes. It is also strongly expressed in the atrioventricular valve. During postnatal development, it decreases in both atria and ventricles. In the adult heart, expression is found in the aortic valve in scattered cells and in the atria, ventricles, and septum. Interestingly, it is markedly up-regulated in hypertrophied adult ventricles of transgenic mice overexpressing the angiotensin II receptor (at protein level)
+First detected in fetal liver and embryonic thymus
+Expressed at 11.5 dpc and 12.5 dpc in distal limb and genital bud
+Detected throughout the embryo at 10.5 dpc. High expression in epithelial cells of the lung, kidney, bladder, colon, testis, in the smooth muscle of the colon and small intestines, and in the mesenchymal cells adjacent to the olfactory epithelium at 15.5 dpc
+Expressed throughout development and in adulthood
+Expressed after initiation of oocyst sporulation
+During the early development (9.5-12.0 dpc) it is expressed in the developing nervous system such as the cranial ganglia, neural tube, sympathetic chain and dorsal root ganglia. Also found in the lens, vomeronasal organ and endolymphatic sac
+Expression is first detected at the three-fold stage during embryogenesis
+Maternally expressed, expression declines during gastrulation and continues at a lower level until late stages. Ubiquitously expressed at gastrula stage. Later in development, becomes enriched in the head and brain
+No detectable expression
+Expression in cardiomyocytes is higher in adult as compared with neonatal
+Expression is restricted to preimplantation embryos and peaks at the 8-cell to morula stage
+First detected in the corneal epithelium and lens epithelium at 6.5 dpc and 12 dpc. At 12 dpc is present in the corneal endothelium and the limbal region. After 16 dpc and at hatching (H1), expression persisted in multiple anterior segment tissues, including the lens epithelium, the corneal endothelium, the iris, and the trabecular meshwork (at protein level)
+Expressed in the otic vesicle at 6 days post-fertilization, with highest expression in the developing semicircular canals (at protein level). Detected in the notochord at the tailbud stage. Expressed in somites, notochord and intermediate mesoderm during early somitogenesis. Expressed in the otic vesicle from 24 hours post-fertilization onwards
+Expressed in embryos (at protein level) (PubMed:11441002). Expressed in the H-shaped excretory cell and pharynx in L2 larvae and adults (PubMed:11441002)
+Expressed throughout development (PubMed:24882217). In L4 larvae and young adults, expression is highest in the intestine, rectal epithelial cells, vulval epithelial cells, spermathecae, and pharynx and absent from the gonads (PubMed:24882217)
+During fruiting and upon induced sporulation
+Present throughout oogenesis and early Xenopus embryogenesis; in adult tissue it is primarily detected in blood
+Accumulates next to spores within the exosporeum
+Expressed both maternally and zygotically. Zygotic expression begins after the neurula stage
+Expression in brain increases progressively from four days to adulthood
+Most abundant during embryonic and larval development
+In spermatids, isoform 1 is expressed until spermatids become elutriated, whereafter isoform 2 is expressed
+Expressed throughout embryonic development. At 9- to 16-somites, transcripts are broadly expressed with specific staining observed in the developing nervous system, somites, and precardiac mesoderm. At later stages 1- to 3-days post-fertilization, transcripts become more localized within the dorsal diencephalon, the otic vesicles, and the fin buds
+Expression correlates with egg production
+During lateral root development, expressed in the prospective quiescent center of lateral root primordia. In newly formed lateral roots, strongly expressed in the quiescent center and initial cells and weakly expressed in the endodermis
+Expressed during all stages of the life cycle
+Expressed at low levels in trophozoites (at protein level)
+Expressed in the developing brain, cochlea and limb buds
+Detected from early pachytene spermatocytes and throughout spermatogenesis
+Expression peaks during late aggregation and slug stage
+Expressed throughout the development of the leaves
+Highly expressed in the stigma of unopened flowers, peaks on day 1 postanthesis and drops rapidly on day 2 postanthesis when the stigma becomes receptive (at protein level)
+Expressed at low levels in L1 larvae and increases at the L3 stage to the adult stage
+Expressed in the lateral cortical plate at 18.5 dpc and only very weakly expressed by cortical neurons at 15.5 dpc. Expression progressively increases in layer IV neurons of the prospective somatosensory, visual and auditory cortices. At much lower levels, also expressed by scattered neurons in layer V in these areas. By P4, expression is striking in the whisker barrel cortex of the somatosensory cortex. During retinal development, isoform 1 is broadly expressed in between 13.5 dpc and P5 then declines and is maintained at lower levels into adulthood. At 15.5 dpc, is expressed in the immature cochlea, brainstem, spinal cord and cerebral cortex. Isoform 2 is first detected at low levels at late embryonic stages (18.5 dpc), the expression highly increases during the first postnatal week and is maintained during the adulthood
+Expression under developmental regulation, the mRNA starts to be expressed after 8 hours of development
+During germination and leaf development, expressed in the new developing organs
+Expressed over the entire range of development
+Highly expressed in the node and midline and weakly expressed in 8.5 dpc embryos and in the lateral plate mesoderm
+Expressed both maternally and zygotically. Weakly expressed during early embryonic stages but increases during 12-24 hours of embryogenesis through larval development and continues to be expressed throughout adulthood, albeit at slightly lower levels in males than females
+Detected at embryonic day 17 dpc and postnatal day P1 in retinal astrocytes, spinal cord astrocytes and Schwann cells of the dorsal root ganglion
+Expressed in developing seeds from 5 to 30 days after flowering (DAF) (PubMed:16798940). Expressed in germinating seeds up to 5 days after imbibition (PubMed:11470159)
+Expressed in the otic vesicle, mandibular arch, branchial arches 2 and 3, in proximal anterior mesodermal domain in the limb, immature and proliferating chondroblasts at 14.5 dpc
+During gestation, expression in the uterus is relatively constant between 34 and 47 days, increases by approximately threefold relative to the expression level of 34 days by 54 days and persists at the elevated levels through term
+Expressed in embryos and the L1 larval stage (at protein level) (PubMed:11341844, PubMed:18828672). Expressed in embryos and adults, with lower levels in L1-L4 larvae (PubMed:9858614, PubMed:14629117)
+Expression increases during bone marrow-derived macrophage (BMDM) differentiation: expression is much higher in primary macrophages than monocytes
+Mainly expressed in leaf mesophyll cells, and, at low levels, in root vascular tissues
+Expressed throughout development (PubMed:27451901). Diffusely expressed from the gastrula stage to the 3-fold embryonic stage (PubMed:27451901). In larvae, expressed in hypodermal tissues and processes of the nervous system, including commissures, sensory dendrites in the head, and lateral nerve tracts (PubMed:27451901). In L3 and L4 stage larvae, mainly expressed in body wall muscles, and it is also expressed in head neurons and ventral nerve cord neurons (PubMed:27705746)
+Expressed maternally and then widely throughout embryogenesis. During the neurula stage, highly expressed in the neural plate and neural fold. Strong expression also seen in brain, eyes and spinal cord at the tadpole stage
+Expressed in endosperm of developing seeds from 10 to 30 days after pollination, with a peak at 25 days
+Expressed throughout early development
+Expressed in the developing retina between 16 and 19 weeks post-conception, specifically in the outer neuroblastic zone, inner neuroblastic zone, interphotoreceptor zone and the retinal pigment epithelium (at protein level)
+Peak of expression 4 weeks post flowering, at the time when tartaric acid biosynthesis occurs
+Expressed at stage 7 of embryonic development in the folding anterior part of the neural plate. At stage 8, high levels in all four newly formed epithelial somites and in the rostra1 paraxial mesoderm. Expressed also in the cephlic region of the developing neural fold. Later expression in the entire limb bud, including mesenchyme and ectoderm. In the developing brain, first detected at stage 7 in the anterior portion of the neural folds that are destined to give rise to the telencephalon. Later in development (stage 25), glypican transcripts were found in postmitotic cells in the mantle zone. Expressed by ectodermal and ingressing chick trigeminal placode cells at the time they differentiate into neurons and assemble into ganglia. Also expressed in the migrating hindbrain neural crest cells from rhombomeres 4 and 6 during migration at stage 12
+Expressed only in fruiting dikaryons
+3 EF-1-alpha are expressed under different developmental control in Xenopus laevis
+Expression widely distributed both maternally and zygotically. During gastrulation, strong expression in the posterior end near the blastopore
+Detectable in the brain at embryonic day 17. The levels increase to reach a maximal value at postnatal day 18
+Initially detected in mesendodermal cells at late blastula stages. During gastrulation, expressed in a broad marginal domain and becomes excluded from the ventral animal pole at late gastrula stages. During segmentation, initially exclusively detected in the somitic mesoderm but later also in the otic and optic vesicles. During organogenesis, expression is largely down-regulated in the somites but maintained in the otic vesicles and the retina
+Pituitary levels are highest in non-photostimulated and incubating birds and lower in photostimulated, laying and photorefractory birds
+Expressed in growing oocytes
+Expression starts at 8.5 dpc in the trigeminal ganglion, the VII-VIII neural crest complex, and the subventricular neuroepithelium of both forebrain and hindbrain regions. At 11.5 dpc, expression is detected in the neural crest-derived sensory nervous system and, at 15.5 dpc, in the brain, spinal cord, retinal neuroepithelium and the inferior XI/X complex (PubMed:11336497, PubMed:11245580). In postnatal and adult animals, expression is confined to the cerebellum and dorsal root ganglia (PubMed:11336497). Expressed in the cornea epithelium at both 18.5 dpc and early postnatal (P5) but not at P50, when the corneal epithelium is fully differentiated (PubMed:28916725)
+Expressed maternally. Present at near constant levels throughout early development
+Xenin is released into the circulation after a meal
+Highest levels are found in embryo and adult. Levels decrease during the first and second larval instar and then decrease in third instar larvae and early pupae
+Expressed by newborns dendritic cells
+Expressed at 3-days but not at 11-days of age in both female and male GH transgenic mice. Expression in the normal female mice begins as early as 2 months and is detected at much higher levels at 5, 12 and 24 months while at 30 months, expression is lower
+Expressed 2 days before visible senescence began (PubMed:9617813). Detected from day 24 (PubMed:18978034)
+In the heart, expressed from embryonic day 10.5. Continues to be strongly expressed throughout cardiac development and into adulthood (PubMed:11335131)
+Detected early throughout the shoot apical meristem, but not in the emerging leaf primordia. Restricted later to the junction between sepal and petal primordia
+Accumulates in seeds after imbibition (PubMed:23893219). High levels in the aerial portion of 10 days old seedlings. Accumulates in the epidermis during cuticle biosynthesis (e.g. in inflorescence stems). Also detected in flowers, in upper portion of the styles, pollen, veins of the sepals and petals, silique walls and seeds in the early stages of development (PubMed:23893219). In epidermis, present in trichomes, leaf mesophyll cells, and stem cortex and xylem
+Protein is present throughout the entire cell cycle
+Expressed at high levels throughout all developmental stages
+Alternatively spliced, in part by RNA-binding protein asd-2, to produce isoforms which are expressed at different developmental stages (PubMed:18230701). Isoform a: Predominantly expressed in embryos (PubMed:7691828, PubMed:18230701). Isoform b: Predominantly expressed in larvae and adults (PubMed:7691828, PubMed:18230701)
+Expressed at 7.5 dpc, increasing by 9.5 dpc, concomitant with cranial neural tube closure, and at 11.5 dpc (PubMed:18179478). Expression levels were relatively stable between 12.5 dpc and birth, continuing into adulthood (PubMed:18179478)
+Detected in the apical ectodermal ridge (AER) during limb development as well as in the distal region of the ectoderm
+Expression starts at the embryonic bean stage in several anterior cells and continues until hatching (PubMed:16154558). Between the 1.5-fold and pretzel embryonic stages, expressed in a subset of pharyngeal cells and several anterior body wall muscle cells (PubMed:16154558). Expressed in the M lineage-derived coelomocyte precursor cells M.dlpa and M.drpa and in the 6 differentiated coelomocytes throughout development (PubMed:19427847). Expressed in the M4 motor neuron sister cell (PubMed:20713707)
+Expressed during embryogenesis starting at 9 hours of development
+From 6 days to 7 months, levels of KPI-containing isoforms increase in the brain cortex and hippocampus. Levels of L-APP increase in all brain regions during the same period, but levels are low compared to non-L-APP isoforms
+Appears at 9 hours of development, and at 12 hours of development significant levels are found in the developing brain posterior to ocular vesicles. Distributed mainly in the midbrain, part of the diencephalon beneath the epiphysis and in the epiphysis at 18 hours of development. Found in the ventral part of the midbrain and in the dorsal part of the diencephalon at 24 hours of development
+Expression in testis detected after stage P20, when haploid germ cells appeared in testis
+Expressed throughout the developmental cycle of the schistosome, with the highest expression in 14-day old schistosomula. Expressed in superficial structures of the miracidia and sporocysts, with high expression in ciliated epidermal plates of the miracidium, and in the longitudinal and circular muscles of the sporocyst. High expression also in the optical sections of germ cells in miracidia and 2-day old sporocysts. Expressed along the protonephridial ducts of the cercaria, extending laterally nearly the whole length on both sides of the larva. More specifically expressed at the collecting tubules of this osmoregulatory system. Expressed ubiquitously in the schistosomulum. In adults, expression is higher in males than in females
+First detected in the retina at 51 hours post fertilization (hpf) along the nasal edge of the choroid fissure. By 55 hpf expression has extended into the nasal region and by 72 hpf it covers the whole retina
+Expressed in preimplantation embryos
+Expressed in the root excluding the apex and at leaf primordia (PubMed:22323769). Accumulates in cotyledons, hypocotyls and leaf veins of young seedlings (PubMed:22323769). Negatively regulated during infection by the bacterium Ralstonia solanacerum (PubMed:18596930)
+Slight expression at 8.5 dpc, increasing till 11.5 dpc and remaining continuous thereafter, suggesting regulated expression during development
+At 7.5 dpc, it is expressed in all three germ layers, although it appears to be more expressed in the embryonic ectoderm and the node. Widespread expression persists at 8.5 dpc, although it is clearly expressed at higher level in rhombomeres 2 and 4 and branchial arches 1 and 2 (which are populated by neural crest from these rhombomeres). At 10.5 dpc, the dorsal and ventral aspects of the neural tube, brain and midbrain-hindbrain junction show the most intense expression. A day later in development, elevated expression is found in the floor plate and the sclerotome. At 12.5 dpc, both the floor plate and the roofplate exhibit strong expression as the mesenchyme of the limb and of the developing whisker follicles. At 13.5 dpc, it is predominantly expressed in embryonic mesenchyme, especially at sites of epithelial-mesenchymal interactions such as the developing teeth and whisker follicles. Strong expression is also apparent in the perichondria of the cartilaginous skeleton, an important site for the regulation of skeletal differentiation
+Growth regulated
+Expressed at 8.0-8.5 dpc in the foregut endoderm and at 9.5 dpc in cells migrating into the septum transversum. At 10.5 dpc, highly expressed exclusively in the fetal liver. From 10.5 dpc, expressed in the developing liver throughout gestation and in neonates. At 17.5 dpc, detected in the dorsal root ganglia of the peripheral nervous system
+Embryonic expression increases from day 9 to day 12 and then declines to day 15
+Expression in kidney peaks at postnatal day 4 and declines to undetectable levels by day 15. In adults very low expression detected in the basal region of lateral membranes of few tubule segments (at protein level)
+When cells enter the stationary phase of growth, during the vegetative state, subunit VIIe is replaced by VIIs. The switching depends on the oxygen tension
+Expressed from the 4-cell stage through late gastrulation (at protein level) (PubMed:11566890). May be maternally expressed (PubMed:11566890)
+At postnatal day 11 abundantly expressed in the retina outer plexiform layer, outer nuclear layer, and outer limiting membrane, with weak expression in the inner nuclear layer and inner plexiform layer (PubMed:28151698). At postnatal day 22 abundantly expressed in the retina inner nuclear layer, outer plexiform layer, outer nuclear layer, outer limiting membrane, outer segment, and inner segment (PubMed:28151698)
+Up-regulated during the lignification process in inflorescence stems
+Expression is developmentally regulated as axonal fibers innervate, extend collateral fibers and finally attain a stable state. First detected at postnatal day 6 in cell bodies and apical dendrites of pyramidal neurons in the developing cerebral cortex, with expression gradually increasing during postnatal development. In P1 retina, strongly expressed in the optic nerve fiber layer, and weakly expressed in ganglion cells, presumptive amacrine and horizontal cells. At P10, also strongly expressed in other parts of the retina such as the ganglion cells, inner plexiform layer and horizontal cells. Expression decreases as the retina develops further to maturity
+Detected in notochord and brain at the 14-somite stage. Expressed in the ventral region of the eye and in spinal motor neurons at 32 hours post-fertilization
+Expressed both maternally and zygotically. Expression is high in early and late embryos, and then again early in metamorphosis, followed by reduction to basal levels after eclosion of adult flies in both males and females
+In young buds, confined to sepals and pedicels
+Differential expressed during pseudoglandular and canalicular stages of lung development
+In seedlings, expressed in leaf primordia and young developing leaves. Progressively circumscribed to the adaxial side of developing leaves to become restricted to the veins in fully expanded leaves. In roots, confined to the vasculature. Present in floral buds and young developing flower organs. Accumulates in perianth organs and stamens before being restricted to the vascular system in later postanthesis stages. Strong expression throughout the young pistil. Disappears from the apical stigma during postanthesis fruit maturation. Detected in the style until later stages in fruit development, mainly in style vasculature, but progressively fades away from most of the ovary region
+Strongly expressed in liver, skin, brain as well as in specific regions of the developing cartilage and bone in embryos
+Expressed both maternally and zygotically. Expressed throughout all embryonic stages
+Expressed in the developing forebrain, midbrain and hindbrain at early stages of neuronal development
+Highly expressed during seed maturation. Decreases rapidly after imbibition, becoming undetectable only 5 days after imbibition
+Detected in embryos and larvae (at protein level)
+At 7.5 dpc, strong expression restricted to the ventral node, the left-right organizer (PubMed:27486780). Up-regulated in tracheal epithelial cells during in vitro differentiation into multiciliated cells (PubMed:25860617)
+Accumulates in the columella root cap. Also present in floral organs in young flower buds. Strongly expressed in vascular tissues of filaments and anthers. Weakly and uniformly present in the developing embryo and maternal tissues (PubMed:17287251). Expressed both in proliferating and maturing stages of leaves (PubMed:26069325)
+mRNA and protein levels peak in the sciatic nerve between posnatal days 8 and 20; thereafter they decline precipitously
+Expressed in fetal pancreas
+Expressed from 9.5 dpc to 17.5 dpc in the ventricular layer of the brain and spinal cord, but also in the retinal pigment epithelium, developing eyelids, nasal epithelium, serous gland, vibrissae, epithelium of the mouth cavity and the tooth buds. Highly expressed in the heart, thymus and adrenal glands followed by lung, liver parenchyma, kidney tubules, epithelium of the esophagus and stomach. From 15.5 dpc to 17.5 dpc it is expressed in urinary bladder and urethra. From 17.5 dpc, it is expressed in developing muscle
+Detected at 10 dpc in developing gut, at 14.5 days dpc in the cartilage primordium and in the developing urogenital sinus. Expression increases with gestional age in kidney and duodenum, becoming maximal in adulthood
+At 16 dpc expressed in the liver, amnion and visceral yolk sac. Expression is gradually increased with embryonic age (PubMed:12450124). Expressed in the epithelium and mesenchyme of the palate shelf and jaw as early as 13.5 dpc. This particular mandibular epithelial expression is still present at 18.5 dpc (PubMed:28301481)
+First expressed at the 100-cell stage of embryogenesis. During embryonic elongation, expressed in anterior, posterior and midbody cells of the embryo and in cellular projections. At hatching, expression is restricted to a few cells in the head and a pair of cells in the tail
+Synthesized during maturation of epidermal keratinocytes and localized in the upper intermediate cells of fetal skin. Earliest expression is at 10 weeks in the developing embryo in the presumptive nail bed of developing digits, shifting to the proximal nail fold by 13.5 weeks. At 12.5 weeks, detected in scattered cells of the intermediate layer of trunk skin. At 19.3 weeks, regional expression patterns were observed in upper intermediate keratinocytes of cheek, trunk, dorsal and ventral knee, elbow and dorsal hand. Distal areas around the periumbilical region showed increased number of positive cells and by 15 weeks is expressed in small groups of cells in the fetal hair follicles
+Expressed throughout growth and development with a strong peak of expression at 4 hours when aggregation is initiating
+First detected from days 15 and 17 embryos
+In brain, expression increases from 12.5 dpc to adulthood
+Also present in inflorescence axil branches and in anther and pistil of developing flowers (PubMed:10948254). At anthesis, restricted to anthers (PubMed:10948254)
+Expressed at pupal stage only
+Expressed in adult females and embryos (at the protein level)
+Expressed in mammary glands at various stages of development, with weak expression detected in virgin goats and during pregnancy and lactation and high expression detected at the stage of involution
+Expressed throughout development, with high levels before metamorphosis and low levels in pupae
+Expressed during early seed development and late developmental phases of siliques
+First observed in 16-cells stage embryo and surrounding region. From early heart to early torpedo stage, confined to the developing vasculature of the hypocotyl, cotyledons, and developing root. Faint expression in the emerging shoot apical meristem (SAM) at the torpedo stage. After germination, present in root, shoot and inflorescence meristems, as well as in young flower primordia and ovules (PubMed:18381924). In roots, detected in the stele, endodermis basal and cortex cells, and at the end of the root meristem, comprising the quiescent center, surrounding initials, and vascular precursors (PubMed:18381924, PubMed:27229734). Also present in the vasculature of primary and lateral roots, in the pericycle at sites of lateral root initiation, in lateral root meristems, and in the vasculature of the leaves. Accumulates in stamen and carpel primordia. Expressed in young provascular tissue of floral organs and stem tissue (PubMed:18381924)
+Up-regulated between days 3 and 12 after germination and during senescence
+Expressed maternally (PubMed:30467143). Transcripts are first distributed evenly in blastomeres (PubMed:30467143). During the early cleavage period, transcripts in the vegetal pole region are transported toward the animal pole from one side of the yolk (PubMed:30467143). Transcript levels decrease 2 hours post fertilization (PubMed:30467143). The protein is enriched in a small region of blastomeres, in which the dorsal organizer will form (at protein level) (PubMed:30467143)
+Expressed uniformly in the embryonic hindbrain
+Not detectable in females on the first day after eclosion, but is detectable on the second day. It is maximally expressed by day 4
+Expression increases as fruit matures
+Expressed zygotically. First expressed at the midblastula transition (MBT)
+Expressed during development; especially between 8 and 12 hours of development
+First expressed in 20-30 cell stage embryos and expression continues through to adulthood
+At stage 18, expressed throughout the dorsal central nervous system (CNS), both within the brain and the spinal neural. Strongest expression is observed within the tectum and the cerebellar primordium. Expressed also in the somites, the heart, the branchial arches, and the limb buds
+Widely expressed in roots, shoots, leaves, culms, spikelets and anthers during different developing stages
+Maternally expressed. Expressed from 5.5 dpc, and expression remains high throughout development. Expression decreases during differentiation of embryonic stem cells (ES cells). Expression increases in prostate during prostate tumor development
+Up-regulated during leaf senescence
+Expressed in the central region encompassing the endplate area of the diaphragm muscles at day 14.5 of embryonic development (14.5 dpc), when AChRs cluster in a nerve- and agrin-independent manner
+At late neurula stage (stage 20), strongly expressed in the developing cement gland and in the bilateral heart primordia. Expression in the cement gland decreases from stage 25 onward, while expression continues to be strongly detected in the developing heart. In the heart-forming region at stage 25, expression seen in the heart field formed by fusion of the bilateral heart primordia and also seen in the hindbrain (rhombencephalon) at this stage, corresponding to the second and fourth rhombomeres. At stage 29/30, expression persists in these regions and also weakly detected in a more posterior region of the hindbrain. At stage 33, when heart looping is initiated, broadly expressed in the heart tube, ventricle, atrium and both branches of the sinus venosus. During heart looping (stage 36), expressed at a higher level in the atrium than in the ventricle
+Expressed from late differentiation to the transition stage
+Expressed maternally and zygotically in the larvae
+Expressed during embryogenesis specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary, respiratory systems and in spiral septum of the heart and in epicardial precursor cells fated to form the coronary arteries. Expression pattern is sex- and stage-dependent during gonadogenesis. At 13.5 dpc expressed at higher levels in testis than ovary. In 3-month old adults expression drastically decreased in testis while it increased in ovary showing an opposite sex-dependent pattern in adults compared with fetuses. Expression in other organs was similar between the adults and the fetal stage
+Expressed during embryogenesis, in larvae and in adult animals
+Expressed from day 3 of gastrulation, expression levels are maintained until day 10
+Expressed throughout development, beginning at embryonic stage 12 when levels steadily increase and then drop dramatically at third-instar larvae. Levels increase in 24 hour pupae and remain until adulthood
+Accumulates in young seedlings with a peak three days after seed germination (PubMed:11726703). Mostly abundant in young seedlings grown in darkness, but quickly down-regulated during further seedling development and by light exposure (at protein level) (PubMed:16244150)
+During anther development, expressed from stage 8 to stage 12
+In neonatal animals, highly expressed in skin
+Expressed early in development of the eye (week 9 to week 22 of gestation)
+Up-regulated during early S phase of the cell cycle, and sustained through G/M phase. Low expression levels in quiescent cells
+First expressed in a stripe covering the head anlagen of the syncytial blastoderm embryo, persists through gastrulation and decays during germ band extension. Expressed later in development in a complex spatially restricted pattern
+Expressed from embryogenesis (PubMed:24140420). Expressed during larval development and adulthood (PubMed:21531333)
+Expressed throughout embryogenesis, as well as in larvae and adults
+Expressed in a cell cycle-dependent manner. Most abundant in mid-S phase
+In the cochlea, low expression at P0 and P15, then rises significantly by P30 and remains steady. In the HC11 cell line model, up-regulated during differentiation of mammary cells into milk-secreting cells (at protein level)
+At 20 weeks of gestation, expressed in multiple brain regions, including the developing neo-cortical plate, subplate zone, striatum, globus pallidus, thalamus and subthalamus
+Moderate levels in unfertilized eggs and during early cleavage, then rapidly increases in abundance between late morula and mesenchyme blastula stages to maximal levels maintained through subsequent stages. Expressed both maternally and zygotically
+Embryonic brain. Not detected during blastula or gastrula stages. At the 4-5 somite stage, expressed in the diencephalon just posterior to the optic vesicles, and weakly in the hindbrain. By the 14 somite stage, there is widespread expression in the CNS, particularly in the ventral diencephalon, optic stalks and anterior hindbrain
+Highest expression levels in young seedlings and much lower expression abundance in the later developmental stages
+In the root epidermis, expressed transiently in the root maturation zone
+Expressed first at late gastrulation stage in cells that include descendants of the AB and E lineages (PubMed:9685266). Expression detected in dorsal body wall muscle (BWM) at the 1.5-to 2-fold stage of embryogenesis; also in some of cells in the head, including one ventral muscle (PubMed:9685266, PubMed:27341757). Between 520 min and hatching, expressed in the DA and DB motor neurons, excluding DA8 and DA9 (PubMed:9685266). This pattern of expression persists into adulthood (PubMed:9685266)
+Low levels at the G1-S boundary increase in intensity during S phase and until the end of the G2 phase. Abruptly decreases in late mitosis (at protein level). Barely detectable in anaphase
+In all developmental stages analyzed. Its signal was more intense in sporulating mycelium
+Expressed in all cells of the developing spermatheca and in the spermatheca-uterine junction core cells at larval stage L4
+Expressed in seedlings, from 6 to 21 days after germination
+Detected in blastula and gastrula, in dorsal mesoderm
+Expressed during the asexual blood stage, including rings, trophozoites, schizonts and free merozoites (at protein level)
+First observed in the embryo at four-cell stage. At the globular stage, localized in cotyledons primordia. Later confined to embryonic cotyledons tips. Expressed from embryogenesis onward in the central zone of the shoot apical and floral meristems, in organ anlagen, and (transiently) in the distal domains of organ primordia
+Higher expression level in the premolt stage in hepatopancreas (2.7-fold), muscle (5.2-fold) and epidermis (2.3-fold) compared to the intermolt stage. Expression is down-regulated in the postmolt stage in hepatopancreas and muscle, but remains high in epidermis
+Expressed in the root quiescent center (PubMed:15937229). Accumulates in division zone of primary root tips and emerging lateral roots. Also present in floral organs in young flower buds. Weakly and uniformly present in the developing embryo and maternal tissues (PubMed:17287251). Expressed specifically in proliferating stage of leaves (PubMed:26069325)
+Zygotic expression first appears at the morula stage. In blastocysts, expressed in the inner cell mass and trophectodermal cells. In postimplantation embryos, expression becomes ubiquitous
+Expressed in embryos, larvae and adults (at protein level) (PubMed:11707440, PubMed:15456850, PubMed:16857685, PubMed:24829385). Expression transiently increases during early embryonic stages and prior to the larval L1/L2, L2/L3, L3/L4 and L4/adult molts (PubMed:11707440, PubMed:16857685). Highest expression in adults (PubMed:11707440). In embryos, expressed in gut cells (PubMed:11707440). In larvae, expressed in the hypodermis, intestine and pharyngeal lining (PubMed:11707440). In molting larvae, expressed in the old and new cuticle (PubMed:11707440)
+Ubiquitous expression in embryos
+Expressed only in the forespore compartment of sporulating cells. Disappears after 45 minutes of spore germination
+Expressed in cardiac progenitors during embryogenesis and up-regulated during gastrulation
+Expressed at low levels during embryogenesis. Expressed in the ventral fin fold of the forming and extending tailbud and in the ventral regions of the neural tube
+Expressed in the floor plate throughout the period of commissural axon pathfinding (PubMed:7651410, PubMed:10704386). In myogenic progenitor cells, highly expressed during early development (11.5 dpc) and progressively repressed as developments proceeds (PubMed:27446912)
+Expressed in embryo testis
+Highly expressed in embryo. Expressed at very low levels in adult
+Expressed during fruit ripening, but not during fruit development (PubMed:18359841, Ref.3). Expressed during leaf senescence, but not during leaf development (Ref.3)
+Not found in embryos. Increasing amount as stems mature
+Expressed in whole brain tissues from 11.5 dpc to adulthood
+Accumulates during flower development with highest levels in open flowers, and fades out as flowers are senescing
+Not detected in the embryo. Expressed at the early larval, late larval and adult stages, with highest levels at the late larval stage
+Expressed in nurse cells and oocytes of all stages (PubMed:26851213). Expressed in oocytes and embryos and down-regulated afterwards (PubMed:10856248)
+Detected at 67 dpc in the primary ossification center and is tightly restricted to the pericellular region of the hypertrophic chondrocytes and lacunae at the very center of the future diaphysis. At fetal 20-week highly abundant in the hypertrophic zone at the chondroosseous junction. Weakly detected around cells in the resting and proliferative zone of the cartilaginous plate, but the intense detection occurred deep in the hypertrophic zone near the newly formed bone. Detected throughout the extracellular matrix (ECM) in this zone it is also closely situated around hypertrophic chondrocytes
+During lung development the expression is detected from 15.5 dpc to P1 with a maximum at 17.5 dpc which corresponds to the stage of development of alveolar saccules
+Expressed preferentially in the tachyzoite stage
+Observed in all organs primordia and meristems. In cotyledons, hypocotyls and differentiating leaves, present in stomatal meristemoid cells, guard mother cells and trichomes. Within the anthers, transiently expressed in the proximity of the sporogenous tissue. Accumulates in embryos at globular stages, except in suspensor cell. In root elongation zones, mostly present in epidermal cells, particularly in trichoblasts
+Expression increases during development from embryo to adult
+Expressed during the parasite blood stage, including in trophozoites (at protein level)
+At 15.5 dpc, expressed in kidney, ureter and bladder (PubMed:29100090). At 16.0 dpc, strong expression in the liver, thymus, intestine, kidney, and brain. In the brain, high levels in the ventricular zone and in the neopallial cortex. In the kidney, highest levels in the nephrogenic zone located in the cortical region of the kidney. Also observed in epithelial cells of the differentiating renal tubules. At P0, strong expression in the nephrogenic zone (PubMed:29100091). In the inner ear, prominent expression is observed between 13 and 16 dpc (PubMed:29955957)
+Expressed during sporulation. Detected in mature spores (PubMed:3080407)
+Detected in both the small cell variant (SCV) and in the large cell variant (LCV) stage (at protein level). LCVs are more metabolically active than SCVs
+Expressed during seed development (PubMed:18567831). Exclusively expressed in the endosperm of developing seeds (PubMed:18849529)
+Ubiquitously expressed at constitutive levels during embryogenesis
+Expressed throughout development, with low levels of expression in embryos and 1st instar larvae, and highest levels of expression in adults (at protein level)
+Expressed in all developmental stages from early embryo to adult (PubMed:9037110). Expressed in extended germ band embryos and in somatic mesoderm, yolk cells and midgut during late embryonic stages (PubMed:2903049)
+Expressed in temporal bones at 15 dpc through postnatal 30, levels decrease thereafter, but is still present in the inner ear at P180
+In males, expression begins at late larval stage and continues in adults
+Expressed under both yeast and hyphal conditions of growth
+Expressed in embryo at 15 dpc onwards
+Accumulates in the basal embryo region that gives rise to hypocotyl, root, and root stem cells. Expressed in the root meristem throughout embryo development
+Expressed in embryos at 7 dpc. Not detected at later stages, including 11, 15 and 17 dpc (PubMed:9671792). In the testis, expression restricted to middle and late pachytene spermatocytes (PubMed:9671792)
+Produced between days 10 and 15 of pregnancy and at day 15 found in both the peri-implantation conceptus (trophectoderm and yolk sac) and the endometrial surface and glandular epithelium. Found in allantoic fluid at day 30 of gestation
+Levels peak during the late embryonic stages. Slight increase in expression at the mid-larval stage that decreases over the pupal stage and then slightly increases in the adult
+Expressed at low levels in 37-day sporocysts, increases 25-fold in the infective cercarial and early schistosomular stages. Levels decrease dramatically in adults, adult males have approximately twice the expression level as in adult females
+Expression is first detected in the testis 5 weeks after birth and coincides with the appearance of spermatozoa. In the brain, expression is first detected 3.5 days after birth
+Expressed both maternally and zygotically (PubMed:10842088). Zygotic transcription is initiated in the early gastrula embryo in paraxial mesoderm that is fated to give rise to somites (PubMed:10842088). During the course of gastrulation and neurulation, it is expressed in somitic paraxial mesoderm is centered within the myoD expression domain (PubMed:10842088). Expressed in developing somites at larval stages (PubMed:25217815). As development proceeds it is also expressed in the cardiac primordium and the lens vesicle (PubMed:10842088, PubMed:25217815). Expressed in hypaxial migrating cells and branchiomeric cranial muscles (PubMed:25217815). In the heart expression is confined to the myocardium (PubMed:10842088)
+Expression in total brain lysate is weak but seems to decrease with age as detected from 17 dpc to 12 months
+Detected in whole embryos at 7, 11, 15 and 17 dpc. Also present in limb buds from 13.5 dpc. At 16.5 dpc, it is expressed throughout the developing nervous system, eye, inner ear, kidney, thyroid gland and teeth
+Expressed in the testis in Sertoli and periendothelial cells at 14 dpc
+Specifically expressed in the developing protophloem sieve elements soon after the phloem-specific cell divisions have taken place. Also found in the companion cells and metaphloem sieve elements. May not be necessary for the initial steps of protophloem differentiation
+Weakly expressed in G0/G1 phases, abundant during S and G2/M phases, and strongly decreases thereafter
+During embryonic development is highly expressed in several types of mouse tissue undergoing high rates of programmed cell death such as central nervous system and kidney
+Expressed in developing cortical plate, amygdala and subcortical regions and in the ganglionic eminence
+Found in spores. Expression is high during polar tube formation
+Maternal protein whose levels decrease in late stages of oocyte maturation
+In testis, expression levels increase from postnatal week 4 onwards with peak levels at postnatal week 8. Expression remains high thereafter
+Expressed from 1 to 10 days after flowering
+Associated with larval metamorphosis
+First detected between embryonic day 15 and day 16
+At the globular stage, expressed in cells adjacent to the hypophysis and at later embryonic stages, restricted to the future root stem cells
+Detected at 15 dpc in the cortex and cerebellum and at postnatal day 2 and 4 in the cerebellum (at protein level)
+First expressed in mid-embryonic development, in the head mesodermal cell, (hmc), a single pharyngeal muscle (pm8), a pharyngeal gland cell pair (g2L/R) and four of the six pharyngeal intestinal valve cells (PubMed:33021200). Around hatching, expressed in some head and tail sensory neurons, including the phasmid neurons PHA and PHB (PubMed:33021200). During larval development, expression is the same in both sexes until the larval L4 stage to adult molt, when expression in PHA and PHB in the male disappears, but continues in the hermaphrodite (PubMed:33021200)
+Expressed almost uniformly in early embryos
+Expressed throughout development at a low level
+Probably expressed only during sporulation in the forespore
+Expressed during neural and epidermal differentiation. Expression restricted to proliferating cells prior to differentiation. Specifically expressed in the S phase of the cell cycle in neuronal progenitor cells. In the developing embryo, detected from 9.5 to 12.5 dpc especially in the ventricular zone of the neuroepithelia, in the progression zone of the limb buds and in the aortic arches and liver. In the spinal cord at embryonic days 10.5, 11.5 and 12.5 dpc, expressed in the cells at the perimeter of the ventricular zone. In the developing epidermis, expressed only in the uppermost differentiated cell layers underneath the stratum corneum
+Expressed in pstAO cells
+Expressed in bloodstream form and significantly less in procyclic form
+Detected in embryos (at protein level) (PubMed:16467571). Ubiquitous and strongly expressed in embryos at 8.5 to 9.5 dpc. Expression becomes more restricted during embryonic development. Highly expressed in head, eye lens and developing bones at 12.5 dpc. Expression in the eye is decreased by 14.5 dpc. Detected in capillaries and in the photoreceptor layer in the adult eye (PubMed:15377789)
+Expressed in the nervous system during embryogenic stage 21. Expression decreases from stage 25 onwards
+In testis, first observed in non-dividing prospermatogonia after 12.5 dpc and is highest at about the time of birth; expression declines rapidly after birth and is extinguished by 6 days post partum, when most prospermatogonia have differentiated into dividing spermatogonial stem cells (PubMed:15318244)
+Highly expressed in embryos and at L2 larval stage, and to a lower extent in subsequent larval stages and in adults
+In the developing pancreas, detected as early as 10.5 dpc in the majority of epithelial cells. This broad expression pattern persists through 12.5 dpc. Around 13.5 dpc, with the start of the secondary transition, becomes restricted and by 15.5 dpc, exclusively detected in insulin-expressing beta cells and in some scattered ductal and periductal cells (at protein level)
+First expressed at a low level at stage 12, with expression gradually increasing up to stage 22. From stage 24, expression increases sharply and continues at a similar level as development progresses through the tadpole stages
+Expressed primarily during the first half of embryogenesis
+In the embryo, found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud
+Peak of expression in seeds between 3 and 28 days post-anthesis
+Between 7.25 dpc and 8 dpc, expression detected in the extraembryonic mesoderm and contributes to amnion and chorion. Allantois expression persists until 10.5 dpc and continues into the umbilical cord. Expression is found throughout heart development. At 7.5 dpc, detected in the cardiogenic mesoderm, at 8.0 dpc-8.5, found in the cardiac crescent and looping heart tube and from 9.5 dpc, found in the forming four-chambered heart. At all stages, expression is much stronger in the myocardium than in the endocardium and expression extends from the cardiogenic into the lateral plate mesoderm. From 10.5 dpc on, weakly expressed in the periphery of the liver lobes, and in cells surrounding the aorta in the urogenital system. At 9.0 dpc, weakly expressed in the dorsal half of the optic vesicle. Later, expression spreads ventrally to enclose the entire neural retina at 11.5 dpc. At 9.0 dpc, expression is initiated in the hindbrain: first in the ventral region of rhombomere (r) 2 and 4, then in r7, r8 and in the cervical spinal cord. By 10.5 dpc, two ventral stripes of Tbx20 containing cells are continuous from r2 into the cervical spinal cord and expression is seen in two symmetrical patches of cell bodies in the mantle region of the ventral neural tube. At 11.5 dpc, expression follows the migration of motor neurons
+First detected in the embryonic node at 7.5 dpc. At 8.5-13.5 dpc, strong expression is detected in tissues that are either mono- or multiciliated, such as the eye, notochord, floor plate of the neural tube and all 4 choroid plexi. Expressed during development and early postnatal life in all 6 sensory regions of the inner ear
+Expressed during oocyte maturation with levels remaining constant throughout this period (at protein level)
+First detected in the mesoderm at 7.5 dpc By 8.5 dpc highly expressed in presomitic mesoderm, mesenchyme and endothelial cells, while much lower levels are seen in the neuroepithelium. Between 9.5-10.5 dpc expressed at high levels in the neuroepithelium. At 13.5 dpc expressed in the surface ectoderm, eye and developing whisker follicles. Hair follicle matrix cells expression starts as different cell types become distinguishable in the developing follicle. Expression persists throughout the growth phase of the follicle and maintains the same expression profile in the second hair cycle. The cells in the follicle that undergo a phase of high level expression are in transition from mitotic precursors to several discrete, differentiating cell types. Specifically expressed in cerebellar Bergmann glial cells during postnatal development
+Expressed in the developing brain at 12 dpc. Expression increases postnatally and is maintained at an adult level beyond 4 weeks after birth
+Expressed from early embryogenesis
+Expressed in developing ovaries and larvae (PubMed:11880382). Expression increases from 1- to 4-day-old larvae, decreases in 5- and 6-day-old larvae and newly formed pupae, and becomes undetectable in 12 h pupae (PubMed:11880382)
+When eel matures sexually and migrates back to deep sea breeding grounds the visual pigments in its rod photoreceptors change from being maximally sensitive to green light to being maximally sensitive to blue light. In part, this change in sensitivity is due to a change in the opsin component of the visual pigment molecule; this green sensitive rhodopsin is expressed during life in greener inland and coastal waters
+Constitutively expressed throughout development (at protein level). Expression peaks at the aggregation stage, decreases at the tipped aggregate and remains low at later stages. Expressed more abundantly in the extreme tip of the prestalk region, slugs and early culminants
+Expressed both maternally and zygotically (PubMed:20226781). Present in one-cell embryos (PubMed:20226781). Levels decrease during epiboly and increase during segmentation stages (PubMed:20226781). At 24 hours post-fertilization (hpf), expressed in ventral craniofacial domains and along the yolk-endoderm boundary (PubMed:20226781). At 2 and 3 days post-fertilization (dpf), widely expressed throughout the head, appearing in the pharyngeal arches, eye, fin bud, neurocranium, notochord and brain (PubMed:20226781). At 5 dpf, expression localizes to the developing pharyngeal arch cartilages in both chondrocytes and perichondrium (PubMed:20226781)
+First observed in root vascular tissues and root caps (PubMed:19912567). During arbuscular mycorrhizal (AM) symbiosis with (AM) fungi (e.g. Glomus versiforme), accumulates transiently in the root epidermis and outer cortical cells coincident with hyphal penetration (hyphopodia), and later present in cortex cells during arbuscule formation (PubMed:19912567)
+Expressed in central nervous system and heart tissues in early development stages and in most organs at later stages (at protein level). Detected in embryos from 9 dpc onward with higher expression in differentiating neuronal tissues at 11.5 dpc
+In leaves, restricted to midveins and petioles (PubMed:29258424). In flowers, present in stamen and pistils styles and stigma (PubMed:29258424)
+During in vitro ciliogenesis translocalizes from the cytoplasm to the ciliary transition zone during epithelial cell polarization
+Expressed in flagellate > amoeba > plasmodium
+Expressed in all the normal larval stages observed
+First appears in blastoderm embryos. It is absent in subsequent embryo stages, and then reappears in late embryogenesis to be found in larvae, pupae and adults
+Expressed in the retinal pigment epithelium and in the melanopore precursors at 1 day post-fertilization
+Expressed in the early epidermis
+Expressed in brain throughout development
+Expressed both maternally and zygotically, with expression persisting to at least tadpole stages
+First expressed at 12 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 11. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf
+Expressed in floral organ abscission zones (AZs) prior to cell separation and subsequent shedding. Also present within the style of developing fruits, at the bases of cauline leaves, and in the stems of the first rosette leaves
+Expressed in 4-cell stage embryos and during larval stages L3 and L4
+Expression first appears at Hensen's node and subsequently in the axial and paraxial mesoderm. When the neural tube closes, strong expression is transiently found in the roof plate region from the rostral midbrain to the hindbrain
+Barely detectable at post natal day 0, reaching maximum expression after the third week of life
+CNS development
+Expressed in the L1 cell layer of the embryo 2 days after pollination
+Expressed in interphase and M phase cells. Down-regulated by the miRNA miR338-3p
+First detectable at the mid-gastrula stage. Disappears at the end of the somitogenesis
+Expressed throughout early embryogenesis
+In developing lung, high expression at day 17 after which levels decline to barely detectable levels at birth. Levels then increase postnatally until postnatal day 6 and decline in adulthood. Preferentially expressed in proliferating cells
+Detected at 15.5 dpc in the cortex, expression increases at 18.5 dpc, after birth and to adulthood. Expression increases in late-stage neuronal progenitor during their terminal differentiation
+During pollen development, accumulates progressively from the immature tricellular pollen (TRCP) stage and in mature pollen grains (MPGR)
+Specifically expressed during initiation of the shoot apical meristem, when cotyledonary primordia arise at the flanks of the apical embryo domain phase. Confined to the initiating vascular primordium of the cotyledons during heart and torpedo stages, but only weakly expressed during bent cotyledon stage
+Expressed during plant development. During pollen development, required for crosporogenesis that leads to archesporial formation and for the histogenesis of the microsporangia. During ovules development, involved in the transition to meiosis of the megaspore mother cells
+First detected during pregastrulation stage, levels increase up to the hatching stage, and is still present at the late veliger stage
+The 56 kDa isoform is not detected in etiolated cotyledons The 54 kDa isoform exists even in the dark and increases very rapidly for 96 hours upon illumination
+Constant expression level
+Very low expression in eggs. Expression increases during the first instar larval stage, decreases gradually during the second and third instar larval stages and in pupae and increases in adults
+Expressed early in photoreceptor cell development
+Accumulates progressively during senescence induced by detachment of leaves. In flowers, expressed in anthers and ovules prior to fertilization, and in siliques, present in developing seeds
+Mostly expressed in embryos. Also slightly expressed in adults, but the toxin is not found in adult venom
+Expressed in growing cells, its mRNA continuously decreases during development. Highly expressed during phagocytosis of non-pathogenic bacteria
+Increases as cells progress through G1, peaks during S and G2 phases and decreases as cells enter mitosis during G2/M (at protein level)
+Expressed in the cortex of root colonized regions by arbuscular mycorrhizal fungi (e.g. Glomus versiforme), and, to a lesser extent, in noncolonized lateral roots
+Expressed constitutively during plant development, weak increase during flowering
+Expressed during development in tissues rich in mitochondria, such as heart. In liver, low expression level observed in embryos and newborn animals increases 10-fold in adult
+Active only in the forespore (PubMed:18208527)
+Detectable in the adrenal gland of newborn animals
+Expressed both maternally and zygotically. Localized to the prospective animal pole during oogenesis. Ubiquitous expression during the blastula stages. During early gastrulation, levels are higher ventrally and in the presumptive shield (organizer region). Later in gastrulation, expression is restricted to midline and ventral cells. At the start of somatogenesis, expression is restricted to notochord, lateral plate mesoderm and a stripe of anterior dorsal neuroectoderm. By the 19-somite stage, expression in the lateral plate and midline diminishes but forebrain expression persists. All expression is lost by 24 hours post-fertilization (hpf)
+Not expressed in the first stages of embryogenesis. Levels increase during late embryogenesis and decrease in germinating seedlings
+The expression of collagen IV undergoes a developmental shift in the developing lens capsule. During the early stages of lens capsule development expression of collagens alpha 1(IV), alpha 2(IV), alpha 5(IV) and alpha 6(IV) is observed; this is consistent with the presence of fibrillar alpha 1(IV)-alpha 1(IV)-alpha 2(IV) protomers and of elastic alpha 5(IV)-alpha 5(IV)-alpha 6(IV) protomers. In the later stages of development components of the more cross-linked alpha 3(IV)-alpha 4(IV)-alpha 5(IV) protomer appear
+Expression in limb tissue from 5-6 weeks embryos; persists throughout development
+Expressed in the intestine at the L4 larval stage and persists into adulthood (PubMed:30956009, PubMed:31675356). Expressed in sensory AWC neurons, pharyngeal muscle cells pm6, and intestine, in the adult (PubMed:30956009, PubMed:31675356)
+In 23-week-old embryo found in epithelial podocytes of the periphery of mature and developing glomeruli
+Firstly detected at 8.5 dpc in pharyngeal arch regions, particularly in the first arch, and in developing outflow tract (OFT) regions. Expression continued through 9.5 dpc in the cardiac outflow tract and atria, and in second heart field (SHF)-containing pharyngeal arch with additional expression in lower craniofacial regions. Also expressed in the developing outflow tract and SHF-associated pharyngeal mesoderm, with additional expression observed in pharyngeal endoderm, outflow tract endocardium and ventral neural tube populations
+First expressed around day 15, increased thereafter, and reached the maximum level of expression in the adult brain. In vitro, in neurons, expression started at 12 dpc, increased thereafter in parallel with process of spine formation, and reached its maximum level after 25 days
+Up-regulated when resting T- or B-lymphocytes or hemopoietic progenitors are activated. Down-regulated when a monocytic leukemia cell line, M1, is induced to differentiate. Expressed in brain at 17.5 dpc (at protein level)
+Most abundant mRNA species from cotyledons at early stages of development
+Selectively expressed in stalk cells
+Moderate expression in G0 and G1, increasing in S and G2, and dropping in prophase, metaphase and anaphase (at protein level)
+Highly expressed during early anther development
+At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 6. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 3/somite 4 boundary
+Low levels are found at mesenchyme blastula stage (24 hours), levels increase by late gastrula stage and are maintained at pluteus stage
+In embryos, expressed in the muscle founder cells (FCs) and the fusion-competent myoblasts (FCMs) (PubMed:17537424). Expressed in myoblasts of stage 13 embryos (PubMed:17537424, PubMed:25797154). Expressed in the visceral mesoderm from stage 10 and the somatic mesoderm from stage 11, and expression persists until stage 13 (PubMed:17537424)
+Detected in brain cells adjacent to the mushroom body. Expression is low in wandering larvae, elevated 6 hours after puparium formation and back to low levels 12 hours after puparium formation. Detected in infiltrating processes of a subset of glial cells adjacent to mushroom body dorsal lobes
+First observed in embryos from the heart stage and throughout embryo development, restricted to the basal part, constituting the developing radicle. During the curled cotyledonary stage, strongly expressed in the radicle and detectable in the cotyledons. On germination, mostly present in root tips, but also at low levels in the cotyledons and hypocotyl. In flowering plants, restricted to the root tip and to the silique wall
+Expression is elevated in liver after birth but starts to decline around postnatal day 16
+Only present in A-cells and in A/B diploid cells
+Only present in a-cells and in a/alpha diploid cells
+Expressed in embryos at 5.5, 6.5 and 7 dpc (at protein level). Expressed in the trophoectoderm cells and inner cell mass of blastocysts (at protein level)
+Expressed in the shoot apex and young developing leaves (PubMed:15125775). In seedlings, present in the shoot apical meristem and throughout the lamina of young leaves primordia (PubMed:15125775). In cotyledons, stems and mature leaves, restricted to the vasculature (PubMed:15125775). Weakly expressed floral meristem primordia (PubMed:15125775). During flower development, first observed in the center of the floral meristem, in the L3 and underlying cells (PubMed:15125775). In floral buds, observed at low levels in the center of floral meristems and accumulates progressively in sepals, petals and in the center of developing stamens (PubMed:15125775). In mature flowers, confined to the vasculature of all floral organs (PubMed:15125775)
+Present in the germline just prior to overt spermatogenesis; once sperm differentiation begins, it disappears
+Expressed throughout the larval brain, ventral nerve cord (VNC) and neuromuscular junction (NMJ) (at protein level)
+First expressed during L4 and peaks in the adult male
+Highly expressed in 10.5 dpc embryo limb buds, in an overlapping pattern with PTCH1 and GLI1
+Early larval stages produce only traces of obp, but its synthesis increases dramatically during the fifth larval instar, then it decreases but persists in hemolymph of adults
+Expression begins in the embryo at 8.5 dpc. Oocyst, optic cup and pelvic anlage show strongest expression. At 10.5 dpc, expression concentrated in epithelial cells of the dorso-lateral, posterior and anterior otocyst wall. Expression in the eye is found fairly evenly throughout the retinal neural epithelium, with some enrichment in the inner retina where cells begin their differentiation to form retinal ganglion cells. Some expression is seen in the lens pit and in the cell layer that will become the pigment epithelium. At 11.5 dpc, when the superior semicircular canal has begun to form from the posterior otocyst, much of the expression is concentrated there, although there is also expression in the part of the otocyst that will form the lateral or horizontal canal. Strong expression was also seen in the acoustic ganglia and cochlea. In the eye the expression pattern is similar to that found in 10.5 dpc except that expression is concentrated in the retinal ganglion layer. As the lens vesicle forms and matures at 13 dpc, expression is also seen in the anterior wall of the lens, but persists throughout the neural retina, especially in the peripheral retina where cells are still differentiating
+Expressed from mid-gastrula to the tadpole stage. Appears to be largely absent from terminally differentiated cells of the adult
+Expressed throughout development (PubMed:30336114). First expressed in embryos at the 1-cell stage (PubMed:30336114)
+Expressed throughout the embryo at 9.5 dpc-15.5 dpc. Brain expression increases during the first two weeks of postnatal development
+Expression peaks around 16.5 dpc, when de novo methylation takes place in male germline
+Embryonic expression begins at the neural plate stage and continues throughout development to adulthood
+Expressed under normal growth conditions and is deactivated upon initiation of development
+Isoform A and isoform C are expressed both maternally and zygotically
+In testis, expressed in the nuclei of spermatogonia at all stages of the seminiferous epithelial cycle, and in meiotic prophase cells such as preleptotene, leptotene and zygotene, and weakly in early pachytene spermatocytes, but is absent in late pachytene spermatocytes, spermatids and mature sperm (at protein level)
+Expressed throughout development, with higher expression in larvae than in embryos (at protein level) (PubMed:11181081). Higher expression in males than females, with strongest expression at the third instar larval stage (PubMed:20458515)
+Mid-blastula, decline by tailbud
+During colonic wound repair, highly up-regulated (more than 1600-fold) in the mesenchyme of the wound bed 2 days after injury as compared to uninjured mucosa. Further increase in expression is observed at day 4 following injury (close to 2200-fold). Down-regulated at day 6 (only 93-fold increase as compared to uninjured mucosa)
+Expressed from the twofold embryo stage through to L4 larval stage (PubMed:11333230). Expressed in the embryonic mother cell of Q and V5 neuroblasts, AB.p(lr)apapaa, and abolished in V5 neuroblasts after division but maintained in Q cells until they divide (PubMed:28716930). Expressed in P-neuroblasts before hatching, maintained while P nuclei migrate into the ventral midline in early L1-stage larvae, and declines after P-neuroblasts divide (PubMed:28716930)
+Gradually accumulates during seed maturation to reached maximum levels in dry seeds. Fades progressively upon germination
+Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14, 15, and 16 and in tubular and follicular structures of the fetal gonads
+Expression increases during fertilization of the oocyte
+Expressed during early development of the extraembryonic structures, nervous system, vascular system and inner ear. Also expressed in mesenchyme of various parts of the embryo and in adult hair follicles
+At 7.5 dpc, expressed in the embryo, but not in the extraembryonic region containing the ectoplacental cone
+Expressed in the larva (at protein level) (PubMed:14638854). Highly expressed both maternally and zygotically (PubMed:10924475)
+Expressed from stage 12 embryos and continues throughout development. Isoform 4 is expressed from stage 14 in the somatic component of the embryonic ovary
+At 8.75 dpc, strongly expressed in the cranial neuroepithelium, and also expressed in neural tube, paraxial mesoderm and gut. At 10.5 dpc, expressed in neural tube, forebrain, somites, ventral body wall, heart and gut. At 14.5 dpc, expression is restricted to skeletal muscle, tips of the digits and forebrain
+Expressed in fetal brain and heart
+Localized throughout the animal hemisphere of early cleavage stage embryos and becomes localized above the dorsal blastopore lip during early gastrulation. As gastrulation proceeds, the expression extends along the dorsal midline. In stage 17 embryos, expressed in the notochord and floor plate. At this stage, also detected in the cement gland, where they are maintained in later developmental stages. Additional expression is also detected in the pineal gland, as well as the trigeminal and geniculate ganglia. In stage 27 embryos, expressed in the floor plate and in addition, present in the hypochord and the marginal zone of the ventral neural tube where postmitotic neurons are located
+Detected at 20 dpc, and between P0 and P5 in olfactory mitral cells. Detected between 18 dpc and 20 dpc, between P0 and P10, and in adult in anterior olfactor, hypothalamus ventromedial nuclei. Detected at 15 dpc in cortex marginal zone. Detected between 15 dpc and 20 dpc, between P0 and P10, and in adult in cortex entorhinal and periform region, hippocampal regions, basal telencephalon bed stria terminalis nuclei. Detected at 20 dpc, between P0 and P10, and in adult in cortex induseum griseum and tenia tecta, and basal telencephalon olfactory tubercle. Detected between P0 and P10, and in adult in ventral thalamus zona incerta. Detected between P5 and P10, and in adult in ventral thalamus reticular nuclei. Detected between P0 and P10, and in adult in dorsal thalamus regions
+Expressed in expanding premature leaves. Decreased expression in oldest leaves. Expressed at very low level in roots
+Expressed throughout embryonic development. First detected at 7 dpc
+Expression is strong at early stages and decreases as development proceeds. At stage 9, expressed in the segmental plate mesoderm. At stage 15, expressed in branchial axs. At stage 19-27, expressed in branchial axs, limb buds and tail buds. At stage 27-29, expressed in the tips of digits
+Expressed during development stage, in prespore cells
+Not expressed in dormant seeds. First detected 2 days after imbibition, reaching a maximum at 5-6 days after imbibition, then declining
+Free in soil (not as bacteroid)
+Expressed abundantly in the testis at 23 days after birth and later. Expressed exclusively in the germ cells
+Expressed at the first larval stage (L1) in several cell types including hypodermis, muscle, neurons and seam cells (PubMed:9054503, PubMed:11884032, PubMed:16122423, PubMed:16139228, PubMed:26811380, PubMed:31264582, PubMed:30956008, PubMed:21471153). Also expressed in the tail tip and pharynx at the L1 stage (PubMed:26811380). Down-regulated at L2, and absent from L3 and L4 (PubMed:9054503, PubMed:11884032, PubMed:16122423, PubMed:16139228, PubMed:26811380, PubMed:31264582, PubMed:30956008, PubMed:21471153)
+C-MYC I is active in oocytes, while C-MYC II is active in both oocytes and post-gastrula embryos
+At E14.5, expressed in the forebrain, liver, nasal regions, and somites (PubMed:11391004). By E16.5, expression is ubiquitous, with high expression in the liver, intestine, somites, and choroid plexus (PubMed:11391004). By E18.5 expression is more restricted to the choroid plexus, kidney, intestine, and tooth buds (PubMed:11391004). Expressed principally by Sertoli cells (SCs) and the spermatocytes with the highest expression in the primary pachytene spermatocytes within seminiferous tubule stages II-VI (PubMed:31002737)
+Seroin mRNA is high in the silk glands of feeding larvae, declines at ecdysis, reaches a maximum during cocoon spinning, and thereafter rapidly drops to an undetectable level
+At stages 15, 17 and 20, expression is higher in the genital ridge/mesonephros complexes of embryos incubated at the male-promoting temperature. At female promoting temperature, weakly expressed in the genital ridge
+Expressed in embryo
+Low expression in first to third larval instars, but substantially higher expression levels detected at the beginning of the sixth (penultimate) instars. Strongly expressed in seventh (final) instar larvae. High levels of expression are detected on the final day of pupal development in both males and females. On the seventh day of adult life, the levels in females are greater than those in males by a factor of more than three
+Expression begins in the testis at day 21 and increases dramatically from day 28 and thereafter
+Expressed throughout the life cycle: oocyst sporozoites that invade the mosquito salivary glands, salivary gland sporozoites infectious to the mammalian liver, and schizonts/merozoites that invade erythrocytes
+Expressed during the grain filling process
+Expression starts at metamorphosis and continues into adulthood
+Expressed early during development in the neuroectoderm and neural crest
+At 14.5 dpc, only expressed in mesenchymal cells. At 16.5 dpc expressed also in cells lining the vertebrae and tendons of the proximal tail. In late embryogenesis, expressed in mesenchymal cells adjacent to the distal limb bones (tibia and calcaneum), in tendons and in the connective tissue sheath (epimysium) surrounding the skeletal muscle. Also expressed in the epithelia of the epididymis of the testis
+Both isoforms first expressed in stage-2 larvae and then highly expressed during larval and pupal molts. Only isoform E75A is expressed at the time of pupal ecdysis
+Expressed in the axils of leaf primordia and leaves from P1 to P20/22. In the axil of P1, expressed in 3 to 5 cell layers including the L1 to L3 layers of the shoot apical meristem (SAM). Then, extends from 1 or 2 cell layers in the adaxial-abaxial dimension. From P5 to P22, expression is restricted to a 1 to 2 cell-layer domain located within primordium. In the axils of older leaf primordia, expression decreases until it is no longer detectable in the axils of primordia older than P20/P22
+Expressed exclusively in the neurepithelium
+Expressed in sexually active or inactive fish
+Expressed in developing skin during and after the stratification process from 9.5 to 15.5 dpc (at protein level). Expressed in ectoderm of the developing branchial arches and limb buds from the 9.5 to 10.5 dpc. Expressed in epithelia of the oral mucosa and skin from the 16.5 to 18.5 dpc
+In embryos, present in the endothelial cells of the paired aortae during vasculogenesis (at protein level)
+At 8.5 dpc, detected in most of the neural plate but is excluded from the presumptive forebrain region. At 9.5 dpc, its expression is mostly restricted to two large regions, the caudal diencephalon/mesencephalon and the spinal cord. By 10.5 dpc, is present throughout the neural tube, and it is also detected in the cerebral cortex. It is also strongly expressed in the developing subcommissural organ (SCO) from 14.5 dpc to birth
+Down-regulated during seed maturation
+Highly expressed in the initial stages of development (4-cell up to 1k-2k cell stages). Up-regulated during regeneration of the caudal fin after amputation
+Expressed throughout development. Expressed in the neural crest, eyes, yolk syncytium, tail bud and caudal somites of somitic embryos. Expressed in the neural crest, gill covers and gill arches, and the pectoral fins of post-somitic embryos
+Expressed during sporulation and active during germination. Exists as mature but inactive form in the dormant spore
+Expressed in brain at 17 dpc and in cerebellum at 19 dpc
+Its synthesis occurs around the time of eclosion
+At 17.5 dpc, expressed in a narrow zone in the peripheral outer nuclear layer of the retina. At P12, expressed over the entire photoreceptor layer
+Expressed early in development and up-regulated late in development
+Expressed from the first somite stage. Expressed in lateral plate mesoderm before vessel formation, and thereafter in the aorta but not in the vein. At the 6-somite stage expression is seen in the lateral mesoderm of the head and trunk. While expression in the trunk lateral mesoderm is initially uniform, at the 16-somite stage, expression is restricted to angioblast precursors that have not yet migrated dorsally. At the 16-somite stage expression is also seen in the telencephalon, dorsal midbrain, neural crest and in the dorsal aorta and its vascular progenitors
+Expressed at low expression in fully grown oocytes, highly expressed in maturing oocytes undergoing germinal vesicle breakdown (GVBD) and weakly expressed in ovulated oocytes
+Expressed during adipocyte differentiation. Expression appears 3 days following induction of adipose conversion
+Expressed throughout embryonic development. Isoform 2 first appears faintly in the testis 3 weeks into postnatal development and its expression level increases after 5 weeks
+Expressed at highest levels in fetal kidney, followed by fetal lung and fetal cochlea
+Merozoite
+Expressed in 7-day and 17-day embryos, but not in 11-day and 15-day embryos, implying its role in mammalian development. In oligodendrocytes, expressed throughout development from the immature stages to the mature myelin-froming cell
+Accumulates after seeds imbibition (at protein level)
+Expressed until 15 dpc. Expression then decreases and increases again in the adult. In differentiating somites, is expressed at low levels in cells emerging from the dorsomedial lip and subsequently throughout myotomes. In the limb buds, is found in myoblasts and myocytes but not in the progenitor cells (PubMed:17194759). Highly expressed in the endothelium and in the smooth muscle layer starting at 13.5 dpc in arterial vessels, but not in veins. At 12.5 dpc, there is no detectable expression in arteries or veins. This pattern persists until 18.5 dpc (PubMed:19144989). Strongly expressed in developing muscle of tongue, cheek, and in extraocular muscle at 11.5 dpc. Found at 18 dpc and P21 in head muscle (PubMed:25220152). Detected in a subset of cells in the ventricular zone (VZ), the intermediate zone (IZ) and the cortical plate (CP) of neocortex and in the ganglionic eminences at 13.5 dpc. At later stages, such as at 16.5 dpc, found in the VZ and IZ, but at very low levels in the CP of the neocortex (PubMed:18997111). Highly expressed in embryonic cells located in the ventricular zone (VZ) of the retinal neuroepithelium that form clusters; is first detected in cells located in the central retina. As the retina grows, expression spreads peripherally along the expanding neurogenic region, being always absent from the ciliary margin zone (CMZ) (PubMed:19389377)
+Expressed during development. Expression levels peak at 2 hours, after which they decrease steadily until culmination. Levels increase after 18 hours of development
+Expressed throughout much embryogenesis. Expression peaks at the blastoderm stage (2-4 hours) and at later embryonic stages expression corresponds mostly to the procephalic ectoderm primordium
+Expressed throughout flowering, with higher expression from 1 to 6 days after flowering (PubMed:15759120). During early grain-filling, expressed in the ovular vascular and lateral stylar vascular traces (PubMed:18820698)
+At 9 dpc expressed in extraembryonic mesodermal layers with its prospective blood islands. Expressed in blood islands at day 12 dpc. Expressed by the intraembryonic primary ectoderm including the primitive streak at day 9 dpc. Expressed in the fetal liver and in circulating cells at 17 dpc, the liver expression disappear around birth (at protein level)
+Appears first in early bicellular pollen, peaking in mature pollen
+Expressed exclusively in early Xenopus embryos
+Prominently expressed in two areas, the limb buds and the developing kidney, with diffuse staining in the central nervous system. At 9.5 dpc the limb bud mesenchyme is positive. Expression in the kidney region could be detected as early as 9 dpc in the intermediate mesoderm. By 10 dpc, the mesonephric tubules and nephric ducts are clearly positive. At later stages, high levels are localized to the developing tubules. At 18.5 dpc, it is localized to more mature renal tubules located in the developing cortex with little expression detected in the nephrogenic zone
+First observed in lateral root primordia (LRP), from the first pericycle divisions. Disappears before root emergence
+Expressed in all blastomeres at the 8-cell stage (PubMed:26178919). Detected in the ventricular zone (VZ) of the forebrain at 9.5 dpc. Clearly detected until 12.5 dpc, the expression decreases and disappears by 15.5 dpc (PubMed:19906856)
+Expressed both maternally and zygotically. Zygotic expression is high in pupae and adult females but low in other stages of development
+Expressed in mammary placodes from 11.5 dpc onward and in the developing intestinal epithelium
+Expression is first detected after midblastula transition, reaches its maximum at stages 12-15 and continues to be expressed until at least stage 27
+After the photoperiodic induction of flowering and in early transition stages, expression is only detectable in the peripheral zone of apical meristems. Later on, it can also be found in floral meristems and in axillary meristems that form secondary inflorescences
+Expressed during sporulation (at protein level) (PubMed:24623719, PubMed:23843742). Expressed during meiosis from the first meiotic nuclear division (PubMed:7954893)
+Expressed between 12 and 19 weeks post-conception (WPC) in Bruch's membrane, with expression in the choroid evident from 14 WPC onwards (at protein level) (PubMed:29777959). Expressed in the inner limiting membrane at 17 WPC (at protein level) (PubMed:29777959). Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age (PubMed:17614963, PubMed:3584091)
+Detected 1 week after birth in developing skin, testes, ovary, kidney and lung
+Only expressed in spermatogonia and early spermatocytes, suggesting that expression is inactivated in the XY body during meiosis
+Expressed in mid-gastrula stages throughout the archenteron and in delaminating secondary mesenchyme cells. At later stages (prism and pluteus) expression is seen exclusively in pigment cells
+Expressed in late embryos, during the L1 to L4 stages of larval development and in adult hermaphrodites
+Expressed as early as day 6 postpartum (dpp), with higher expression in the adult testis
+Detected in embryonic brain, ventral nerve cord and sensory neurons, but not in muscle
+Expressed at low, constant levels in temporal bone from embryonic day 14 to day 1 after birth. Increases by 8 to 16-fold at day 5, 10 and 20 and continues to be expressed up to day 90
+Expressed from trochophore to hatchling stages with maximal expression at hatching and also expressed in the adult (at protein level)
+Restricted to the CNS. At 9.25 and 10.5 dpc, specifically expressed in the dorsal neural tube from the midbrain/hindbrain boundary to the spinal cord. At 10.5 dpc, expressed continuously from the upper rhombic lip to the tail. From 10.5 to 12.5 dpc, located in the most dorsal aspect of the spinal cord, excluding the roof plate, mainly in proliferating progenitor cells; quickly down-regulated in postmitotic neurons. At 11.5 dpc, 3 ventral expression clusters, corresponding to p3, p2 and p0 domains, transiently appear on the lateral margin of the subventricular zone, in addition to dorsal expression. At 14.5 dpc, weakly expressed in cells scattered in the mantle zone. Expression declines after 15.5 dpc. In the 11.5 dpc forebrain, expressed in the ventricular zone of the dorsal thalamus. In the 11.5 to 14.5 dpc hindbrain, dorsally expressed in the upper and lower rhombic lip, in the cerebellar neuroepithelium
+Expressed at the embryonic comma stage and during all the larval stages and in adults
+First observed a bud stage of 0.6-mm, shortly after microspore release from the postmeiotic tetrads. Later restricted within the tapetum, microspores and anther locule. Still visible within the haploid nuclei, each of which had migrated to the pollen cell wall prior to pollen mitosis I. Not expressed later
+First detected at the 8-somite stage in the trigeminal nuclei. At the 10-somite stage, also expressed in the forming hindbrain and in the neural tube. By the 20-somite stage, expression has extended to the dorsorostral, ventrorostral and ventrocaudal neuron clusters, the epiphysis and the hindbrain. At 24 hours post-fertilization (hpf), detected in the developing gut. At later stages, expression is lost from the neural tube but continues in the brain and also appears in the retina and pharyngeal cavity
+Expressed during a short window during embryogenesis between at least stages 12 and 19
+Strongly expressed at 13.5 dpc in a ventro-lateral area of striatum and piriform cortex. At 14.5 dpc, some of the positive cells shift toward the cortical plate. At this stage, strongly observed at the superficial layer of dorsal cortex, whereas that of ventral cortex decreases in its intensity. Expression extended further dorsally at 16.5 dpc. In the dorsal cortex, expressed in the ventricular zone at 13.5 dpc. At later stages, expression shifts to the cortical plate. At 15.5 dpc, localizes to both ventricular zone and cortical plate. At 16.5 dpc, almost all expression is in the deeper cortical plate, although some expressing cells are still detectable in the ventricular zone. In the lateral cortex, weak expression in the lateral ganglionic eminence at 13.5 dpc. At 15.5 dpc, strongly detected in the progenitor zones of the lateral ganglionic eminence and medial ganglionic eminence, as well as in tangentially migrating cells in the superficial area of lateral cortex. In the striatum and ventro-lateral cortex, expressed at both 13.5 dpc and 15.5 dpc
+Expressed in the fetal brain, lung, liver, and kidney
+At 8.5-9.0 dpc highly expressed in liver. Significant expression was also seen in the developing central nervous, somites and cardiovascular tissue. At 13.5-16.5 dpc expression was seen in osteoblasts, respiratory epithelial cells, and nephrons and dermal connective tissue
+Increased expression in embryonal tissues
+Expressed in single blastomeres from 8-cell stage embryos
+Expressed during sporulation, and this requires the RNA polymerase sigma factor SigK
+Prepupal and early pupal stages
+During anther development, expressed in tapetal cells of immature anthers, but not in the microspores or mature pollen
+Up-regulated during the dark period
+It is detected at embryonic day 4 (4 dpc) in forebrain and tectum. There is an increase in levels between 16 dpc and the first few days post-hatch. During 19 dpc to hatch a rapid reduction in the levels is seen with a general increase in expression in adulthood
+Expression is low at earlier stages of erythroid development but is very high in reticulocytes
+Expression begins 20-24 days after birth and is maximal in the adult. The pattern of expression suggests that STK22D is expressed postmeiotically
+Expressed during embryogenesis from 7 to 17 dpc
+Expressed both maternally and zygotically. First expressed at stage II of oogenesis. Maternal expression levels are low and become further reduced after fertilization. Zygotic expression begins at the mid-blastula transition and peaks during the gastrula/neurula stages. A lower level of expression is then maintained during tailbud and later stages
+Expressed from 18 dpc in the outer aspect of neuroblastic layer (NBL)
+Expressed in the growing regions of coleoptiles, internodes, and leaves
+TBX6 is first detected in the gastrulation stage in the primitive streak and newly recruited paraxial mesoderm. Later in development it is restricted to presomitic, paraxial mesoderm and to the tail bud, which replaces the streak as the source of mesoderm
+Expressed both maternally and zygotically. Uniform distribution at the cleavage, blastula, gastrula and early somitogenesis stages. Levels decline during the early gastrula stages. At 26 hours, still expressed in the head, forming gut and dorsal neural tube
+Detected in limb buds at embryonic stages 22-23 (at protein level)
+Expressed during early cleavage-stage embryos before zygotic gene activation (ZGA), metaphase II (MII) oocyte, 1-cell, and 2-cell stage embryos
+Detected in the presumptive hindbrain and notochord from the 3-somite stage onwards (PubMed:22252497). Expression in notochord becomes restricted to the posterior as development proceeds (PubMed:22252497, PubMed:22609016). Shows particularly strong expression at the hindbrain-rhombomere 1 boundary during the 12-18 somite stages (PubMed:22252497, PubMed:22609016). Expressed in ventral spinal cord neurons and ventral somite cells at 24 hours post-fertilization (hpf) (PubMed:22252497). Becomes restricted to trunk-tail motor neurons at 32 hpf (PubMed:22252497, PubMed:22609016). Detected in eye primordia from the 10-somite stage onwards (PubMed:22252497). At 24 hpf, expression in eye is found in the ventral retina and optic stalk, and also weakly in dorsal retina (PubMed:22252497). Expressed in the eye choroid fissure and ganglion cells at 32 hpf (PubMed:22252497, PubMed:22609016). Also found in thalamus, posterior tuberculum, head mesenchyme, pectoral fins and pronephric duct at 32 hpf (PubMed:22252497)
+Expressed in grains from mid-maturation onwards
+Began to appear at late embryo stage and continued to increase in abundance throughout the larval stage. They are not present in pupae but reappeared in the adult
+Expressed in both embryo and adult. Expression in the embryo is detected from 8.5 dpc. In the retina, expressed at high levels at postnatal 0 dpc. Expression in brain and retina decreases postnatally but still detectable in adult
+First expressed at 9.5 dpc. Levels then increase until 14.5 dpc after which they remain high until newborn. First detected in the eye at 10.5 dpc and then expressed in tissues associated with skeletal tissue. At 12.5 dpc expressed in the vertebral rudiments in the tail region and, in the developing eye, in lens epithelium. At adulthood, expression found in the ganglion cell layer and the inner nuclear layer of the retina. In the developing heart at 16.5 dpc, expressed in the endocardial cushion. In the trachea at this stage, in outer layers and in the aorta, in adventitia
+Expressed in schizonts (at protein level)
+Expressed in the early seedling stage of post-germinative growth
+Wool follicle development
+Expressed at the 2-cell stage, and at the morula and blastocyst stages
+Expressed throughout embryonic brain development with high levels detected at 11.5 dpc, 13.5 dpc and 18.5 dpc. Also detected at high levels in the adult brain
+Expressed in pollen throughout pollen development, peaking at the time of flowering and in ovules of open flowers
+Expressed in the exponential growth phase
+Expression increases in prostate during prostate tumor development
+Expressed at all developmental stages, with the highest levels at the first larval instar
+Not expressed during gastrulation. First detected at the 8-somite stage in the ventral region of the MHB and in the anterior somites. At the 14-somite stage, expressed in the anteromedial margins of the somites and in the optic stalks. At 24 hours, expression is lost in the somites but observed in the otic vesicle. At 30 hours, expressed in the hyoid and at 36 hours in the dorsal diencephalon
+Detected in stromal cells of fetal liver at 10.5 days. Expression was maximal after 14 days of development and decreased thereafter. Detected at low levels after 18 days
+Expressed both maternally and zygotically. Expressed in both egg and central cell before fertilization. After fertilization, it is expressed in the embryo and endosperm, then decreases during seed maturation
+Expressed at embryonic day 13.5, 14.5 and 16.5. Expression decreases in intensity at day 18.5 and in 1.5 day-old newborn
+Expressed in developing anthers from stage 8 to stage 10 (PubMed:23519457). Expressed in developing anthers from stage 7 to stage 11 with a peak at stages 8 and 9. Highly expressed in the tapetum (PubMed:23385589)
+Detected in the cardiac crescent at 7.75 dpc and in the linear heart tube at 8.0 dpc and the developing atrial and aortic ventricular chambers until birth. Also detected in a subset of vascular and visceral smooth muscle cells: aortic arch arteries at 9.5 dpc; walls of the esophagus, dorsal aorta, pulmonary outflow tract, lung, gut, stomach, small intestine, bladder, and the head mesenchyme at 13.5 dpc until birth. Not detected in skeletal muscle cells
+Expressed at onset of, and throughout sporulation
+Strongly expressed in nascent leaves and, as leaves grow, progressively restricted to the vasculatures, leaves tips and hydathodes along leaves margins (PubMed:29897620). In roots, accumulates in the tips, vasculatures and lateral root initiation sites (PubMed:29897620). In flowers, present in anthers, pollen and pistils (PubMed:29897620)
+Expressed in all larval stages. Expression decreases in adults
+During embryogenesis, first observed at the globular stage and accumulates in cells next to the suspensor, including lens-shaped cells (PubMed:30737509). Expressed in the inner basal edge of endodermal cells in the primary and lateral roots (PubMed:30737509)
+First detected at sphere stage (4 hours) in a small group of cells at the margin of the blastoderm. As epiboly starts, it extends over the whole circumference of the margin of the blastoderm, while it is not detected in the yolk syncytial layer. Expression domain extends over 6 rows of cells, that is over a region that includes the precursors of mesoderm and endoderm. At the shield stage, it is also expressed in the invaginating axial mesendoderm. After the shield stage, the abundance of transcripts declines abruptly and only a weak expression is detected in embryos at 60% epiboly and no expression at 70% epiboly or later. Not detected in 4 day old embryos or in adult fish
+Significant expression seen at 17 dpc and not earlier
+Expressed from 7 dpc. Expressed in presomite-stage embryos, before asymmetrical expression of Nodal and Lefty
+Expressed in the mesenchyme of the anterior palate at 12.5 dpc, prior to the time of palate closure. Expression levels decrease at later time periods after palate closure
+Expression begins at about 2 weeks and continues into adult life, mirroring the production of mature spermatozoa
+Maximum expression in cotyledons that just emerged from the seed coat. Low levels in hypocotyls and increasing levels in roots throughout this period of development
+Induced during preadipocyte differentiation
+During the asexual blood stage, expressed in rings, trophozoites, schizonts and merozoites (at protein level)
+Very low expression level 0.5 days after subculture (DAS)
+Expressed both maternally and zygotically. Expression accumulates from stage 17 (neurula stage) onwards
+Expressed at high levels in germinal vesicle stage oocytes at the mRNA level. Expression progressively decreases until blastocyst stage (PubMed:15803458). Detected in later embryonic stages from 9.5 to 19.5 dpc. At 11.5 dpc, the expression is widespread, with no preference for any particular organ or structure (PubMed:8688464)
+Expressed at the 2-fold embryonic stage and throughout larval stages and adulthood
+Highest expression on 18 dpc
+Expressed at early stage of flower development in the spikelet (rice flower) primordia and later in stamen and pistil primordia. Expressed during ovule development in the inner and outer integuments
+Probably maternally supplied, the zygotic expression is detected early during development at the sphere stage but decreases after 7.5 hpf
+Expressed in the final stages of embryo sac development
+Expressed during the asexual blood stage, including rings, trophozoites and schizonts
+In seedlings, present in cotyledons and in the hypocotyl. Later expressed specifically in the leaf vasculature, the vegetative shoot apical meristem and emerging leaf primordia. At the onset of flowering, observed at the shoot apex, but excluded from the first visible floral buds of the bolting inflorescence. In flowers, confined to the vasculature of the sepals
+Highly expressed in early developing kernels
+Expressed as early as 24 hours post fecondation (hpf), expressed at lower levels than leg1a
+Expression is first detected at 9.5 dpc in the central nervous system and the developing heart. The signal detected in heart persists through to 10.5 dpc. Diffusely expressed in developing brain at 10.5 dpc to 11.5 dpc, but by 13.5 dpc expression is mostly confined to the midbrain and forebrain. Also expressed in the spinal cord at 10.5 dpc, and in retinal epithelium from 13.5 dpc to 16.5 dpc. No signals detected in tissues such as the neural crest, facial mesenchyme, and limbs where other Tfap2 genes are expressed
+Expressed during oogenesis, embryonic and larval stages
+Highly expressed in fetal oocytes, and in hematopoietic cells of the fetal liver and bone marrow (at protein level)
+Expressed from the earliest stages of development, and is ubiquitous throughout embryonic development (PubMed:15700158). At stage 16, it is strongly up-regulated in the developing brain lobes, but not in the ventral nerve cord (PubMed:15700158). Also up-regulated in specific regions of the midgut (PubMed:15700158). Expressed during all subsequent developmental stages from first instar larvae through to adulthood (PubMed:15700158). In larvae, expressed in dendritic arborization (da) neurons, with highest levels of expression in class IV neurons compared to the other da classes (PubMed:19855018)
+During embryogenesis, present in the endosperm and the embryo at all developmental stages, including the seed attachment point and the integuments. Also detected in siliques. During germination, first confined to the radicle to later approaches the meristematic region. Finally present in the whole root. Expressed in cotyledons and primary leaves. In opened flowers, present in sepals, stigma, filaments, and pollen
+Expressed transiently in the male germ line after asymmetric division. Present in maturing pollen with highest levels in bicellular pollen
+Expressed in oocytes and early embryos
+Accumulated during S phase of the cell cycle
+At late gastrula/early neurula stages expression is restricted to two stripes in the dorsal side but excluded from the dorsal midline. As somitogenesis commences, expression is localized to the paraxial region, lateral to the involuting neural tube. As development proceeds, expressied forming somites. Expression is stronger in the presomitic mesoderm and decreases as somites are formed
+Expression observed during all tested stages from 18 dpc to postnatal week 6, but it was especially high during the early postnatal stage (postnatal weeks 0-2)
+Expressed along the tract of the anterior commissure between 24 and 30 hours post-fertilization (hpf). At 30 hpf, expressed in cells along the tract of the postoptic commissure. Expressed in preoptic area from 48 hpf until 96 hpf. Expressed in posterior hypothalamus, ventral midbrain, hindbrain and retinal ganglion cells by 48 hpf. These domains of expression persisted and strengthened in older embryos
+It is present in constant amounts in follicular cells throughout vitellogenesis but disappears transiently at the onset of choriogenesis and reappears during the later stages of choriogenesis
+Expressed in the seed coat at the linear cotyledon and mature green stages, when mucilage synthesis occurs
+Expressed in the ipsilateral retinal ganglion cells (iRGCs) of the peripheral ventrotemporal (VT) neural retina, during the outgrowth of the uncrossed retinal projection between 16.5 and 18.5 dpc (at protein level). Expression is down-regulated as RGCs extend toward chiasmatic midline at the optic chiasm
+Expressed from 2 to 6 days after seed imbibition
+Transcribed under cell cycle control, with a peak in the middle portion of the cell cycle. Later, expression occurs in both poles of the predivisional cell
+Expressed during morphogenesis in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells (PubMed:15066124, PubMed:15102704). First detected in the E cell at the 8 cell stage and its daughter Ea and Ep cells until the 24 cell stage (PubMed:15066124, PubMed:15102704). At the 24 cell stage detected in 5 cells including AB descendant cells and also the Ca and Cp cells (PubMed:15066124). At the 200 cell stage, detected in two pairs of MS descendant cells (PubMed:15066124). Thereafter detected in a subset of cells at each stage up to approximately the 400 cell stage, becoming undetectable just before morphogenesis (PubMed:15066124). During morphogenesis detected in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells up until early L1 larval stage (PubMed:15066124, PubMed:15102704)
+Expressed from embryonic day 16, and expression increases to postnatal week 3
+Expressed from embryonic day 9.5
+First detected in stage 11 embryos, in cells close to the gnathal region. At stage 13, expressed in numerous cells that are dispersed throughout the embryo. During organogenesis predominantly expressed under the cuticle in the proventricular zone close to the hindgut. In L3 larvae, expressed in the lymph glands, the hematopoietic organ that flanks the dorsal vessel and in mature hemolymph crystal cells that appear in clusters attached to diverse organs
+Expressed in the anterior neural ridge and in the cement gland Anlage during late gastrulation/early neurulation
+Expression is up-regulated following differentiation of monocytes to macrophages
+Expressed in ookinetes; expression increases during ookinete maturation (at protein level)
+At 14.5 dpc, expressed in large polynucleated cells within the liver. Induced during adipogenesis
+Expressed in the early stage of development and decreased as the age and developmental state of both the plant and leaves increased
+At 16.5 dpc, expressed in osteoblasts surrounding newly formed trabecular bone. At postnatal day 2, detected in most osteoblasts and lining cells, and also strongly expressed in osteocytes. By postnatal week 4, strongly expressed in osteocytes (at protein level)
+Expressed weakly in middle to late embryos, absent in larvae and is most abundantly expressed in middle to late pupal stages
+In myogenic progenitor cells, expressed during early myogenic development (11.5 dpc) to be gradually down-regulated during the fetal stages (from 14.5 dpc to adulthood)
+In embryos, it is first expressed just before elongation
+Is initially expressed throughout the presumptive mesoderm and becomes restricted to cardiac and visceral muscle
+Expressed in the developing gut endoderm, in myotomally derived skeletal muscle, the adrenal cortex, kidney and condensing cartilage
+Expressed mainly in the pharynx in the loop stage embryo. At L1 larval stage, predominantly expressed in the pharynx with some expression in body wall muscle, anchor cells and tail region
+Faintly expressed between 12 and 14 hours of development
+Weakly expressed during 9.5 dpc and 10.5 dpc, expressed at highest level in 11.5 dpc and gradually decreases thereafter. During the cell cycle, it is weakly expressed in G0 and G1 phases. It increases during G1, S, G2 and M phases
+During embryogenesis, highly expressed at 4 days post anthesis
+Expressed in fetal, newborn and 7-day-old testis but not in 21-day-old or adult testis
+In the developing testis, first detected at postnatal day 14 (P14) and levels increase after P20 (at protein level). At P20, detected in pachytene spermatocytes and round spermatids, but not in preleptotene and leptotene spermatocytes. Not detected in testis at P10. Detected in germinal vesicle (GV) stage oocytes and in embryos up to the 2-cell stage, but not in morula or blastocysts
+Expressed at high levels in the asexual blood stage forms
+Expression differentially regulated in the middle silk glands during the final stage of larval growth with highest expression before the onset of spinning
+Expressed 2 to 4 hours after fertilization in the embryo sac and subsequently in developing maternal tissues. By the globular stage, expression is observed in the developing endosperm, integument layers, the embryo proper, and the suspensor of the developing embryo. From the heart stage onward, expression observed in the embryo but neither in the suspensor nor in the endosperm and integument tissues
+Expressed constitutively throughout the life cycle, with slight increases at an early stage of development
+Expressed in the ring, trophozoite and schizont stages
+Expressed only at a certain stage during differentiation in the insect vector
+In brain, expression is abundant in the cerebellum, with less expression in the neocortical, hippocampus and striatum in adult. Neocortical expression increases from embryonic stages to adulthood
+Embryos from days 8-13 show a uniform pattern of expression with somewhat higher level expression in days 8 and 9 in the head mesenchyme as compared to the rest of the embryo. Higher levels of expression are seen in the developing bones of 14 to 16 day embryos. In the 15 day embryo it is detected in the perichondrium and the marrow of the iliac bone and perichondrium of the ribs and vertebrae. In the 16 day embryo it is detected in the perichondrial layer of the developing digits of the forelimb, outer root sheath of the hair follicles of the upper jaw and in the perichondrium of the vertebrae
+Specifically and transiently expressed in root endodermal cells overlying the early stages of lateral root primordia formation
+Expressed in early stages of seed development, until the late globular stage of embryo. Not detected at the heart stage of embryo development
+Detected before the L2 molt stage (PubMed:15960981). Expressed throughout ventral uterine intermediate precursor cells (PubMed:17942488)
+Predominantly expressed in skeletal muscle during embryogenesis. Expression was detected in the myotome at 10.5 dpc and, thereafter, was observed in developing skeletal musculature from 11.5 to 13.5 dpc and increased from 15 to 17 dpc. However, expression in skeletal muscle was not observed in adults. Its expression may be down-regulated as development proceeds
+Expressed both maternally and zygotically. Restricted to oogenesis, early embryogenesis and the adult ovary. Levels decrease after the onset of zygotic transcription (at protein level)
+First detected in young leaves ten days after initiation of germination. Also detected in young roots but not in mature leaves or roots
+During female gametophyte development, detected in the gametophytic nucleus from one-nucleate to two-nucleate stages, and fades out progressively during ovule maturation to be confined to the central cell of mature embryo sac
+Expressed in leaves from the third leaf to rosette leaves from six-week old plants. Expression follows a development-dependent gradient in successive leaves
+Expressed in the elongation zone of the root and in the root cap in germinating seedlings. Expressed later in the internal cells of the root and in the epidermal cells and the vascular tissue of the hypocotyl. By day 7, expressed in the initiating trichomes on leaf primordia and in the vasculature of hypocotyl and cotyledon. At the transition to reproductive growth (day 14), expressed in the vasculature, epidermis, basal mesophyll cells and pith meristem of leaves
+Produced mainly in germinating cells
+Expressed throughout the development and in adults
+Expressed in a wide range of extraembryonic and embryonic tissues throughout development. Expressed at relatively low levels in mid-gestation stage embryos, with expression gradually increasing during embryonic development
+Expressed both maternally and zygotically. Expressed in oocytes and throughout embryogenesis, whereas expression in adults is undetectable
+Primarily expressed by the amastigote stage. Expressed 4 times more in amastigotes than in promastigotes
+Expression may increase during differentiation
+Not expressed at 12.5 dpc. Expressed at 15.5 dpc-18.5 dpc, with highest levels in chondrocytes of developing bone and cartilage and immature proliferating enterocytes of intestine
+Expression starts during embryonic blastoderm stages and is absent by stages 12/13. Reappears in stage 16
+Earliest expression in 4-8 cells of the pharyngeal primordium at around 280-300 min of embryonic development (PubMed:15282157). Expressed just before the comma stage (approximately 350 min) in two groups of pharyngeal primordium cells, persisting until the 3-fold stage (PubMed:15282157). At the 3-fold stage, expressed in several cells of the tail; expression continues in larvae and adults in several cells of the head, including at least two amphid neurons, intestinal cells, three rectal gland cells and 1-2 other unidentified rectal cells (PubMed:15282157)
+Expressed at low levels during hyphal growth in liquid culture. Slightly elevated expression when asexual sporulation is induced. A significant rise can be detected following the developmental sequence of cleistothecia development, which is accompanied by the differentiation of Huelle cells and eventually ascospore formation. This increase coincides with the intermediary phase of the developmental pathway, starting after 72 hours post induction to result in peak levels at approximately 120 hours after the onset of differentiation
+Expressed during both the early and late stages of fruit ripening and during leaf senescence
+Expression is the highest in mycelia, and decreases during fruiting body development (PubMed:26539050). In the fruiting body, present in the stipe but not in the pileus (PubMed:26539050)
+Not expressed in embryos. Does not exhibit diurnal or circadian variation
+Expressed in syncytial embryos
+Expressed in a dynamic pattern in several body structures and organs of the embryo such as limb buds, acoustic ganglion, teeth, heart, anterior pituitary as well as lung and kidney mesenchyme, liver, derma, and periosteum of the vertebral column
+In the egg, the mRNA occurred as a maternal mRNA at a relatively high level, and its level became very low by the neurula stage, then increased steadily thereafter
+In embryos, present in the radicle and in the cotyledons (PubMed:14742878). In growing seedlings, remains present in cotyledons but become restricted to apices in roots (PubMed:14742878). Fades out later in cotyledons but appears at the initiation site of emerging leaves in the shoot apex (PubMed:14742878). Accumulates transiently in leaf limbs and petioles (PubMed:14742878). During root development, expressed in the root apical meristem (root tips) and at lateral root initiation sites (PubMed:12437298, PubMed:10449413, PubMed:14742878). In flowers, observed in anthers, manly in pollen grains, and slightly in sepals (PubMed:14742878). After pollination, accumulates in immature seeds (PubMed:14742878). In seedpods, mainly present in vascular bundles (PubMed:14742878). In nodules, accumulates mainly in the prefixation zone (zone II), where cell division is arrested and cell differentiation and endoreplication occur, as well as infection by symbiotic rhizobia (e.g. bacteroids formation) (PubMed:10449413, PubMed:12953113). After infection with the root-knot nematode Meloidogyne incognita, expressed in giant cells undergoing endoreduplication (PubMed:12437298)
+Expressed in relatively constant amounts throughout the entire differentiation cycle
+Detected 5 weeks after birth in developing ovary and spleen (PubMed:27663720). Expressed in fully grown, germinal vesicle (GV)-intact oocytes, in oocytes at the metaphase II stage and in the 2- to 8-cell embryos (PubMed:15899864)
+Detected in globular to heart stage embryos
+In the embryo, strongly expressed in the neuroectoderm from the earliest stages of neural induction through the late stages of neural tube closure. Detected in the dorso-ventral axis of the neural tube, but not in the floor plate. Expression is low at day 7 dpc; it peaks at 11 dpc, and it remains strong at 15 dpc and 17 dpc. Also expressed in the cochlear epithelium at days 14.5 dpc and 16.5 dpc. Detected at low levels in the outflow tract myocardium from 9.5 dpc with levels increasing by 11.5 dpc
+In seedlings, predominantly expressed in roots. Expressed predominantly in the root, in the vascular tissue of the hypocotyl-root transition zone and, at low levels, at the region of apical meristem and the apex of cotyledons
+Expression begins during formation of the primordia, increases remarkably as the fruiting bodies develop and declines as they mature
+Weakly expressed in embryo compared to VRK1 and VRK3. Expressed from 10.5 dpc to 14 dpc in developing liver and then decreases. It increases again from 17.5 dpc and remains thereafter. Highly expressed in hematopoietic embryonic tissues from 10.5 dpc to 14.5 dpc. Weakly expressed in the yolk-sac
+In CNS isoform L-MAG is the major form synthesized early in development, and it persists as a significant proportion of the MAG present in the adult. In the PNS isoform L-MAG is expressed at modest levels during development; it is absent in the adult
+Isoform 1: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 2: During T-cell development, expressed at low levels at the CD3-CD4-CD8- and CD3-CD4+CD8- stages but up-regulated at the CD3+CD4+CD8+ and CD3+CD4+CD8- stages. Isoform 3: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 5: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 7: Consistently expressed at high levels at all stages of T-cell development
+Three mRNAs are produced during development. The smallest of these (3.5 kb RNA) is the majority species during precellular blastoderm development after which its levels drop rapidly, but persists as a minority species throughout the rest of the life of the organism. The larger two transcripts (4.4 and 5.2 kb RNAs) first appear around cellular blastoderm and levels increase substantially during next few hours and are the preponderant RNA species throughout the remainder of the life of the organism
+Expressed at very low levels in immature seeds and at high levels from 40-75 days after pollination. Expression decreases after 75 days after pollination
+Present at very high levels during anthesis in ovaries, decreases rapidly during fruit development
+Expressed from embryos to adults (PubMed:26357594). First expressed at the 3-fold stage of embryonic development (PubMed:26357594). Highly expressed in embryos (PubMed:26025681)
+In developing leaves, expressed at very low levels in young leaf primordia, but strongly induced after the fourth and fifth days following leaf primordia initiation
+Specifically expressed during anther development, from the meiosis/tetrad pollen stage to the tricellular pollen stage, with a peak at the bicellular pollen stage
+Isoform 1 is expressed at low levels at embryonic day 33 (33 dpc) and in the adult. Isoform 2 is expressed abundantly throughout embryonic development with a peak at 65 dpc and is expressed at lower levels in the neonate and adult. Isoform 1 and isoform 2 are expressed at similar levels in the adult
+Expressed at all stages of nodule development
+Barely detectable in young rosettes, but is strongly expressed during bolting, flowering, and especially fruit development
+Detected at low levels in normal embryonic kidney from embryonic day 14 through birth. Expression increases dramatically within 24 hours following birth and maximal levels coincide with the completion of morphogenesis at 2 weeks of age
+In roots, mostly localized to microtubule-like filaments beneath the secondary cell walls of metaxylem cells
+Expressed during adipogenesis
+In roots, present in the root portion above the meristem, mainly in the root elongation zone and the proximal region of the differentiation zone; restricted to the epidermis (PubMed:23370719). Induced during lateral root formation in mature lateral roots (PubMed:23370719)
+Expression of the protein is enhanced in a ripening fruit
+Not expressed in embryos. Maternal transferrin is used throughout embryogenesis
+Up-regulated during secondary cell wall deposition
+Expressed during early embryogenesis
+Expressed from embryos to adults (PubMed:20026024). First expressed in somatic gonadal precursor cells during embryogenesis (PubMed:20026024). In the L2 larval stage of development, expressed in Z1.pa and Z4.ap distal tip cells and their descendants (PubMed:20026024)
+Isoform c is expressed during dome stage, while isoform a is not expressed until bud stage, following gastrulation. Isoform a shows strong expression during heart looping stages (30-36 hpf) and at 48 hpf
+Expressed between 6 and 50 days after emergence, with a peak at day 12
+Expressed exclusively in the central nervous system of embryos. In the third instar larva, expression is also restricted to neural tissue with specific expression behind the morphogenetic furrow in the developing eye and in the optic lobes within brain
+Required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles
+Expressed both maternally and zygotically during postblastoderm divisions of embryogenesis
+Expressed during the asexual blood stage, including in trophozoites, schizonts and merozoites (at protein level) (PubMed:28810863). Expression increases at the late trophozoite stage (at protein level) (PubMed:28810863)
+Expressed in the pre-somitic mesoderm, mesonephric tubules, Wolfan ducts and collecting tubules of the developing urogenital system. Also expressed in the cranial sensory ganglia, pineal gland and eye
+Constitutively expressed during the cell cycle
+Expressed in fourth and fifth instar larvae. Initial levels decline until day 2 of fourth instar but increase sharply on day 3. Levels do not significantly change on days 0 and 1 of fifth instar, increase on day 2 before falling again on days 3-4 to the level seen at day 2 of the fourth instar. Expression then remains low until the end of the instar
+Copolarizes with BASL, YDA and MPK6 in stomatal asymmetric cell division (ACD) cells
+Expressed in vegetative cells and throughout development. Levels peak during the aggregation stage before declining and then rising again during culmination (at protein level)
+Expression levels remained constant upon induction of erythroid differentiation of embryonic stem cells. Not detected in reticulocytes, but present during differentiation of erythroleukemia cells to erythroblasts
+In young embryos, transient expression in the procambium and, at later stage, expression over the whole surface of the embryo and in the inner tegument, in the area adjacent to the micropyle
+During early development (7 dpc to 8.5 dpc), it is uniformly distributed, with a higher expression in the presumptive neural tissue (head region) while it is not expressed in the heart. From 9 dpc on, it becomes increasingly restricted to the developing brain and spinal cord. With the exception of the floor plate, it is expressed in many cell clusters in the neural tube at that stage. Expressed in dorsal root ganglia and in the neural retina (sensory layer of the retina) of embryos from 11 dpc on throughout development. During mid-gestation, it is particularly expressed in neural tissue thereby shifting to the intermediate and distal layers of the expanding intraneural domains. From late gestational stages on, pronounced expression is detectable only in selected areas of the brain such as the retrospinal cortex. Expressed in neural cell layers in the hypothalamic region at postnatal day 5. In adult brains, it is expressed in many neural cells of the differentiated cortex. Expression is also observed in non-neural tissue such as the developing limbs where it becomes restricted to the interdigital areas. Strongly expressed in the odontoblast layer of the developing teeth and the maxillary bone. In the cerebellum, it is already expressed before the lobules form. At 14 dpc, it is uniformly distributed in the cerebellar rudiment. When lobulation becomes evident, expression is detectable only in the proliferating granule cells of the outermost layer (external granular layer)
+Isoform 1 is highly expressed in early to midgestation embryos, with expression leveling off at 15 dpc. Expressed in yolk sac erythrocytes at 9.5 dpc. After birth, expression in the testes remains at a basal level until puberty, begins to increase at postnatal day 16 (P16) and peaks at P20 to P24. Expression is maintained at a high level throughout adulthood. Isoform 2 peaks transiently at P24
+Maternally expressed. Highly expressed in ovarian nurse cells and transferred into the nascent oocyte
+First expressed in the L1 cells of the lateral regions of a flower primordium at early stage 1, in which the lateral sepals are expected to develop at a later stage. It then rapidly decreases at the late stage 1 and disappears at stage 2. At stage 3, it reappears in all four-sepal young primordia. Not detected at the central zone of the inflorescence meristem and the floral meristem. In stages 4 through 6, when four sepals develop to enclose the flower bud, it is localized at the lateral edges of the four sepals and forms an arch of the L1 cells at the margin of sepals. Expressed in the young primordia of petals and stamens. As the petals and stamens develop, it is limited at the margins of petals and stamens in a way similar to that of sepals. In the vegetative phase, it is expressed at the lateral regions of young leaf primordia, as well as in flowers and floral organs
+In shoots, restricted to the apical meristem (SAM) (PubMed:27006488). In roots, detected only in adventitious root primordia, lateral root primordia, and the root tip meristem (PubMed:27006488). In flowers, expressed in vascular tissues of sepals and petals as well as in stamen filaments and pollen (PubMed:27006488). In young siliques, confined to the style and silique funiculus (PubMed:27006488). In mature siliques, restricted to the abscission zone (PubMed:27006488). During embroygenesis, first expressed at very low levels in seeds at the early developmental stages; accumulates slightly in the late stages (PubMed:27006488)
+Expressed in the embryo and the surrounding maternal tissues, the pericarp and the integuments. Also found in the germinating grain
+Only found in buds 3-5 mm long
+Accumulates in root tips and lateral root primordia. Present in young leaf and stem vascular tissues. Expressed throughout pollen development from very young floral buds to dehisced anthers, especially in microsporogenous cells, microspores, and mature pollen grains. In female reproductive organs, detected in megaspores and embryo sacs from one-nucleate to seven-celled embryo sacs
+Detected during embryogenesis, larval development, and pupal development (at protein level) (PubMed:19559693, PubMed:10749852). Also expressed in the adult (PubMed:10749852). In the embryo, first observed at 12-16 hours and peaks at the end of embryogenesis (PubMed:10436051). Levels drop in the first larval stage and reach a very low level by the second larval stage which continues throughout the remainder of larval and most of pupal life (PubMed:10436051). Expression increases in late pupae and peaks once again in adults (PubMed:10436051)
+Present in seeds and seedlings, levels decrease with seedling age. Light increases the rate of degradation. Present until 9 days in seedlings kept in the dark, not found after 6 days in seedlings kept in the light
+Up-regulated during CD4(+) T-lymphocyte differentiation, in Th0, Th1 and Th2 cells. Not detected in naive CD4(+) T-lymphocytes (at protein level)
+Expressed in the embryo only after day 15. In the adult, expressed only in developing spermatocytes. Expressed in the developing cochlea. Detected only in developing spermatocytes and spermatids in seminiferous tubules. Moreover, first appears specifically in zygotene/pachytene spermatocytes. Found in puddles in the pachytene spermatocytes of all stage tubules and then in crescent shaped structures characteristic of acrosomes in early step spermatids. Detected in mature sperm (PubMed:15892050). Expressed strongly in trophoblast stem cells and further up-regulated in trophoblast giant cells. Expression is maintained in post-implantation placental tissues in utero. Highly expressed from 7.5 dpc trophectoderm to 12.5 dpc placenta. Expression remains baseline in postimplantation embryonic tissues (PubMed:19596312)
+Isoform exonb and isoform D are seen in embryos and adults. Isoform A, isoform F24 and isoform F30 are predominant in embryos and isoform C and isoform E predominant in adults
+Expressed in the developing eye, nose, brain and pancreas (PubMed:21084637). At 9 dpc, expressed in the telencephalon, diencephalon, neural tube, optic vesicle and pancreas. Throughout development, expression continues in the dorsal and ventral pancreas. Expressed during cortical neurogenesis from 11 to 18 dpc. High levels in the early radial glial progenitors from 11 to 14 dpc and gradually decrease thereafter (at protein level). During corticogenesis, the protein level declines faster than that of the mRNA, due to proteasomal degradation (PubMed:18628401)
+Abundantly expressed in the newborn eye
+Expressed in the developing eye at 9.5 dpc, the expression becomes much stronger and additionally expressed in the neural tube and optic and lens vesicles at 11.5 dpc. Expression is then reduced by 12.5 dpc and becomes significantly decreased from 14.5 dpc to 18.5 dpc of embryonic development
+Significantly expressed in the newborn eye
+A weak signal appears 1 hour after induction, maximum levels are reached by 8 hours and remain at a high level over a period of at least 48 hours
+Expressed during gametogenesis. It first appears on the macrogamete and zygote 1-2 hours after fertilization, reaching a maximum 10 hours later on the young ookinete and persisting during early oocyst development
+Expressed abundantly in the early developmental stages
+Expressed during embryogenesis and in adult reproductive tissue and skeletal muscle
+Expression relatively broad during early stages of embryogenesis and more restricted to apical region of the cotyledons in the mature embryo
+In the testis, expressed at low levels in Sertoli cells of 7-day-old mice, barely detected at day 17, and detected at much higher levels in late pachytene/diplotene spermatocytes in the adult. In the nervous system, expressed at highest levels in the adult
+Expression begins in stage 11 (late-gastrula) embryos and then appears to be maintained at fairly stable levels up to stage 45 (late tadpole), when it declines
+Activated at the onset of neuronal differentiation
+Starts to be expressed during S phase with a maximum just before the G2-to-M boundary and disappears in the metaphase of mitosis. Expressed during embryogenesis in the ovule, integuments, egg cell and synergids, and in the embryo up to late-torpedo stage. Expressed during germination in the root apical meristem, shoot apical meristem, vascular bundles of the cotyledons and vascular cylinder of the roots up to lateral roots emergence. Expressed during flowering in the caulines leaves, peduncle, sepals of flower buds, early expanded petals, ovary, placenta, funiculi, devoloping ovules, pollen connective tissues, tapetum, endothecium, epidermis and developing pollen grains
+Only expressed during vegetative cell growth
+Highly expressed in young seedlings up to 4 days after imbibition
+Expressed during the embryonic development (PubMed:11046149). Expressed both maternally and zygotically in embryos (PubMed:11046149). Until early gastrulation, expression is uniformly distributed in the embryo (PubMed:11046149). At mid-gastrulation (stage 11), expressed everywhere with discernible concentration in the mesoderm (PubMed:11046149). After gastrulation (stage 14), expressed in the mesoderm, ventral nerve cord, and brain (PubMed:11046149). At stage 16, elevated expression is also seen in the muscle (PubMed:11046149). Highly expressed in nervous system throughout later development (at protein level) (PubMed:11046149, PubMed:11733059)
+Widely expressed at 13.5 dpc
+In the mature male gametophyte, expressed in the vegetative cell as well as in the two sperm cells. In the mature female gametes, accumulates in the embryo sac; mostly expressed in the central cell nucleus and, at lower levels, in the egg cell and synergids. After fertilization, localized in the syncytial endosperm and in the embryo
+Expressed in embryos at the ~1.5-fold and ~2.5-fold stages in several cells in the head region, perhaps neurons and/or support cells, and expressed at lower levels in seam cells (at protein level) (PubMed:11532911). Expressed in head region of L1-stage larvae, perhaps in neurons and/or support cells; also expressed in seam cells at this stage (PubMed:11532911). Expressed in the vulval precursor cell (VPC) lineages and in VC neurons, starting at about the mid-L2 larval stage (PubMed:12399309). Expression in the head increases with age between days 2 and 12 (PubMed:18662544)
+Predominantly expressed in tissue with fates controlled by the phytohormone abscisic acid (ABA). In roots, expressed in the radicle emerging from the testa, in the elongation zones of roots, and in root cap border cells undergoing detachment. In hypocotyls, detected only during etiolation in the dark. In cotyledons and leaves, restricted to cells surrounding stomata. In reproductive organs, observed in the style after pollination, in the abscission zones of sepals and petals, in the transmitting tract of developing fruits, and in the abscission zones of mature siliques. Also present in pollen tubes
+Expressed both maternally and zygotically. Expressed in oocytes and cleavage stage embryos. Expression increases during blastula stages, reaches a maximum at stage 11 during gastrulation, then subsequently declines to be no longer detectable by the end of neurulation
+Not clearly detected before 12 and 14 hpf. At 18 and 24 hpf, detected in the otic vesicle, telencephalon, and caudal fin. At 30 and 36 hpf, expressed in the otic vesicle, caudal fin, branchial arch, pectoral fin bud, and pituitary gland
+Higher expression in young seedlings than in mature plants
+Expression in the central nervous system starts at 11 dpc, peaks during postnatal development and declines in the adult brain. At P7 and P20, present in several types of post-mitotic neurons, including cortical and hippocampal pyramidal neurons, cerebellar granule cells and Purkinje cells. Absent from mitotic neuroblasts in the ventricular zones
+Detected in testis from postnatal day 20 onwards (at protein level). In developing spermatozoa, weakly expressed in pachytene spermatocytes and round spermatids, and highly expressed in elongating spermatids (at protein level). Detected in residual bodies but not mature sperm (at protein level)
+Expressed in embryo at 14 dpc and in skeletal muscle at 18 dpc
+Expressed at the end of exponential growth under conditions in which the enzymes of the TCA cycle are repressed
+Expression is maximal at stages 24-31, then begins to decline. Expression is low by stage 37 and disappears by stage 39. Does not appear to be expressed in adults
+Highest levels are present in the petals and sepals of young to opening flowers
+In early L1 larvae, expressed in the pharynx, epidermis, and neurons
+Detected at embryonic day 7. Expression decreases by day 11 and increases again between embryonic days 15 and 17
+Up-regulated during promyelocytic cell differentiation along the monocytic pathway, but not during granulocytic differentiation
+Expressed maternally in oocytes and eggs (at protein level)
+Sexual stage (conjugation) of life cycle
+During embryo development, expressed in the functional megaspore until maturity of the embryo sac. After fertilization, expressed in the embryo and endosperm until the early torpedo stage. Not expressed in mature embryo
+Preferentially expressed in embryos, lower expression in later development
+First expressed in midpachytene spermatocytes in stage VII tubules
+Expressed during embryogenesis and larval development (PubMed:17719547, PubMed:7553861, PubMed:8026318). Mainly expressed in the tail during larval stages (PubMed:20711352)
+During embryogenesis, first observed in the apical side of lower tier inner cells at the early globular stage (PubMed:30737509). At transition to heart stage and later in the post-embryonic root and lateral roots, accumulates at the outer apical corner or outer lateral side of young vascular cells, including the pericycle, and outer corners of the hypophysis (PubMed:30737509). Also present in the columella root cap of the primary root (PubMed:30737509)
+Expressed early during seed germination, especially in the preemergent radicle
+Expressed from embryonic day 16 until the adult stage
+First expressed in late embryos and continues through the adult stage. Observed on the surface of gonad, starting when distal tip cells migrate over the lateral hypodermis toward the dorsal muscles
+Expressed during oocyte maturation: reaches maximum levels at stages I-III and then declined through stages IV to VI (PubMed:23827238). During oocyte maturation, levels remain constant (PubMed:23827238)
+Temporally and spatially regulated during development
+In leaves, mostly expressed in young tissues (PubMed:25249475). In fruits, mostly expressed in green grains but fades out as they are yellowing to disappear in red mature grains (PubMed:25249475, PubMed:25190796)
+Only detected in post-aggregative developmental stages, peaking after 16 hours of starvation
+Detected in wing disks (at protein level)
+Expressed in two cell, 4 cell and 300 cell embryos and in the primordial germ cells, Z2 and Z3 (PubMed:33438773). Expressed in the pachytene stage of the meiotic region of L4 larvae (PubMed:33231880). Expressed in germ cells of L4 larvae (PubMed:33231880)
+Expression peaks between dpc 9.5 to 11.5, then decreases during later stages of organogenesis
+First detected at late blastula (stage 8.5-9). Expression then increases with levels peaking during gastrulation before tapering off by neurulation (stage 13)
+At 14.5 dpc detected in lung and skeletal muscle, and by 18.5 dpc detected in skin, whisker, gut and testis
+Expressed in developing caryopses from 1 to 7 days after flowering (DAF) and then declines to nearly undetectable levels by 20 DAF. Expressed in developing pollen from 7 to 0 day before anthesis
+Induced during germination
+Expressed only in early stages of oocyte development. Expression is more prominent in stage I, strongly decreases in stage II and then, gradually disappears
+Expressed at 9 weeks in developing cartilagenous bone rudiments
+Near the primary root tip, expressed in the vascular bundle, endodermis, cortex, epidermis, and lateral root cap. In leaves, present in guard cells leaf epidermal pavement cells and trichomes. In flowers, high expression in the pollen grains, mostly in vegetative nuclei. Also present in sepals, petals, and young siliques. After flowering, the expression level decreases gradually
+Expressed during merogony and a large part of sporogony
+Highly expressed in fetal liver erythroid precursor cells at 14.5 dpc (at protein level)
+Specifically expressed in the ciliated epithelial layer associated with nasal and lung epithelium in 18.5 dpc embryos
+Its expression is already significant at 9.5 dpc, covering the entire embryo except the heart, and it shows only a slight increase in later developmental stages
+Up-regulated during keratinocyte differentiation (at protein level)
+Levels decrease as seedling grow (9-day-old) but is high in 3-week-old plants
+After cell cleavage of the SMDD/AIY mother (ABpl/rpapaaa) at the end of embryonic gastrulation, expressed in AIY interneurons, but not in the sister cells, SMDD motor neurons (PubMed:19386265). During embryonic elongation, expression increases in AIY (PubMed:19386265)
+In the mushroom body, abundant at early larval stages, becomes much reduced in wandering larvae and is undetectable in young pupae. Expressed at higher levels in postmitotic neurons born at early postembryonic developmental stages than in later-born neurons of the same lineage
+Expressed only after meiosis I. Not detected in full-grown stage VI immature oocytes (arrested at prophase I) and in oocytes undergoing germinal vesicle breakdown (GVBD) or meiosis I, while it is present in oocytes from 1-1.5 hour after GVBD, or from the onset of meiosis II
+Detected at low levels from birth to 3 days post partum, thereafter the expression level increases from 5 days post partum to adult. In spermatocytes, shows punctate localization along chromosome axes specifically in early meiotic prophase I cells. Foci start to appear from the leptotene stage, reach their greatest number in the zygotene stage, persist until the early pachytene stage, and finally disappear in the late pachytene stage (PubMed:30760716)
+Detected on male (minus) gametes (at protein level) (PubMed:20335357, PubMed:25655701, PubMed:28235200). Detected at low levels in vegetative cells. Highly expressed in male (minus) gametes, with low expression in female (plus) gametes (PubMed:16378100)
+In the embryo, its expression is primarily restricted to the developing heart. In situ hybridization showed expression at 7.75 dpc in the paired heart-forming primordia prior to linear heart-tube formation. At 8.5 dpc, strong expression is detected in the heart, with equal expression in both heart chambers. Expression is detected in both myocardium and endocardium, and in vascular endothelium. Later in fetal development low levels of expression is detected outside the heart, including dorsal root ganglia and the spinal cord. In the adult, it is expressed at highest levels in the heart, and at lower levels in the brain, skeletal muscle and aorta
+Down-regulated during seed maturation. Up-regulated during germination
+Expressed throughout development. During embryogenesis specifically expressed in developing tracheal regions
+Expressed in the ALA neuron in L4 stage larvae
+Detected in embryonic skin (12.5 dpc and 14.5 dpc) during the formation of hair follicles and at 15.5 dpc in the enamel knot of the developing tooth. Detected in the basal layer of the epidermis and hair follicles of P2 mice
+There are 2 transcripts. The smaller transcript is high in vegetative cells and during early development and rapidly decreases after 12 hours, the time of tipped aggregate formation. A larger transcript occurs at 8 hours of development, remains high through the 12 hours time point, and then decreases, like the smaller transcript
+In the inner ear of the 16.5 day old embryo, expressed only in the cochlear and vestibular sensory hair cells. In addition, expression also occurs in the epithelial cells of the small intestine, hepatocytes, and choroidal plexus
+In testis, weakly expressed in 3-week old mice and strongly expressed after expression of spermatids, especially after 10 weeks of age, during which time MYCBP/AMY-1 is also expressed
+In pancreatic islets, expression increases during aging
+Expression varies across the cell cycle, with highest levels in S phase (at protein level). No statistically significant changes at the transcript level
+During retinal development, is expressed at 12.5 dpc in the dorsocentral region of the retina, and at 17.5 dpc is only very weakly expressed. In the developing optic chiasm is expressed at 12.5 dpc around the junction of the optic nerve and the brain, with strongest expression dorsal to the site at which the optic stalk joins the diencephalon, and also weakly in a subset of the CD44/SSEA neurons. In the more dorsal region of the developing optic chiasm, is expressed in some distance posterior to the axons. However, more ventrally, is expressed in a region directly adjacent to the path taken by the RGC axons. By 17.5 dpc is not longer be detected at the junction of the brain and optic nerve and is only weakly expressed by the CD44/SSEA neurons. Outside the developing brain detected at between 8.5 dpc and 9.5 dpc in the primordiun of the branchial arches, between 9.5 dpc and 10.5 dpc in the posterior dermamyotome. By 11.5 dpc the expression pattern along somite boundaries was most prominent caudally. Weak expression was also observed in the nasal pit at 11.5 dpc. From 13.5 dpc to 17.5 dpc expression was observed in the trigeminal ganglion, in the olfactory epithelium, and in the neural layer of the retina in the developing eye (with strongest expression in the inner nuclear layer)
+Highly expressed in elongating spermatids during histone hyperacetylation
+Accumulates during seed development, seed storage, and seed germination stages (PubMed:33037128). In roots, highly expressed in the stele, but barely detectable in the cortex and epidermis (PubMed:30267471). Not observed in lateral root primordia, but detected in both young and mature lateral roots (PubMed:30267471)
+Weakly or not expressed during seedling growth
+Acts on ABp development during 4-cell and 12-cell stages, and on ABa development during 12-cell and 28-cell stages (PubMed:8156602). Expressed in various neurons, including AWC, during the dauer larval stage (PubMed:18599512)
+High fetal expression with a strong decline after birth. Expressed at 9.5 dpc and 10.5 dpc in nervous system with highest level in telencephalon, diencephalon, and midbrain, as well as regionalized expression in the neural tube, which is characteristic of genes involved in the specification of neuronal fates
+Detected in early stages of embryos as an oval and 2 stripes at HH stage 5, which becomes two lateral stripes at HH stage 7, running along the anteroposterior body axis from the head ectoderm to the anterior region of the primitive streak. At HH stage 8, strong expression in the anterior neuroectoderm, which forms the central nervous system, is observed, and at HH stage 9, expressed in the most anterior region of the forebrain, midbrain, neural groove and Hensen's node. At HH stage 15-16, the expression is seen in the surface ectoderm of the limb-forming fields, in addition to the neural tube. The expression in the limb field became confined to the distal region of the limb at HH stage 16 and 17, with still scattered signal visible in the surface ectoderm of the limb bud. Strongly expressed in the apical ectodermal ridge (AER) and weakly in the ectoderm in the developing limb bud at HH stage 21. The expression in the AER is detected throughout later stages of limb development
+Differentially expressed during development. Small protein species predominate in early embryos and are up-regulated in committed myoblasts and chondrocytes, but down-regulated upon terminal differentiation. Large species are detected mainly in adult tissues and terminally differentiated cells
+Expression is first detected at 10 dpc and reaches a peak at birth. After birth, levels decrease and remain constant throughout postnatal development
+Expressed in gametocytes (at protein level)
+Up-regulated during myogenesis in vitro and muscle regeneration in vivo
+Expressed throughout growth. There is a slight decline of expression during exponential growth and a slight increase after T0
+Levels increase rapidly in brains from newborns, in parallel with myelination in the central nervous system. Present at very low levels in newborns. Levels are highest at 2 to 3 weeks, and then decrease slightly to reach an constant, intermediate level after 4 months. Constitutively expressed at an intermediate level throughout adult life
+Last day of pupal development and adults
+Appears to be present at a low level during early oogenesis, with levels decreasing before oocyte maturation. Levels dramatically increase during embryonic development (at protein level)
+Expression is seen in embryos between 8 dpc and 16 dpc and a peak expression is seen at 14 dpc
+Increase of activity in the apex linked to the early stages of the transition from vegetative to reproductive growth
+Expressed in a cell cycle-dependent manner. Not detected at the G1/S transition, but increases during the progression into S phase and peaks after the passage into G2
+Expressed during the fruiting body stage
+Expressed in a complex banded pattern early in embryogenesis. During maturation of the embryo, expression becomes restricted to cells around and of the gut
+Expressed during spermatogenesis
+Expressed in tracheal pit cells from stage 11. At stage 12, expression becomes restricted to lateral anterior and posterior tracheal branches. Expressed in the highly proliferative region of the eye-head primordium. Expressed in the distal regions of leg and wing imaginal disks
+Not expressed in meristemoids, but strongly expressed in guard mother cells (GMCs) and in young guard cells (at protein level) (PubMed:17088607). Expressed at the transition to terminal stomatal differentiation, just before and after the symmetric division of stomatal differentiation, being confined to late-stage GMC and to young, still differentiating guard cells (PubMed:24571519)
+Expressed during cranofacial development as well as in heart
+Transcripts are up-regulated by 100 fold during adipogenesis
+Weakly expressed during embryogenesis, with stronger expression in the adult eye
+Expressed from late embryonic stage onwards (PubMed:10550049, PubMed:16300753). Shows oscillating expression levels during larval stages, with peak levels in intermolt periods and minimal levels during ecdysis (PubMed:16300753, PubMed:20843862, PubMed:22137474, PubMed:29880558). Expressed in hypodermis, vulva, intestine, muscle, neurons and somatic gonad throughout larval development, in an oscillating pattern (PubMed:16300753, PubMed:22137474). Expressed in sex myoblasts during larval stages L1, L2 and L3, in an oscillating pattern (PubMed:16300753). Expressed in gonad distal tip cells (DTC) during the L2 and L3 stages, in an oscillating pattern (PubMed:16300753)
+Expressed in the pharyngeal myoepithelium, the major body hypodermal syncytium and lateral seam cells from the mid L1 stage. Expression in the hypodermis rises and falls at the start and end of every molt, respectively
+Accumulates during early fruit ripening and then declines
+Induced by starvation and expressed throughout development, with a peak at 8 hours after starvation
+There is one major 'early' isoform and multiple 'late' isoforms. Around 50 isoforms are found at different developmental stages
+Expressed maternally and zygotically. Expressed during oogenesis and embryogenesis. Expressed in larvae and pupae
+Expressed in developing fin bud at 36 and 72 hpf
+First observed in differentiating trichoblast and later confined to root hair proper. Soluble in the early stages of root hair development and becomes insolubilized in later stages
+Present in egg, pupa and imago but not larva (at protein level)
+Expressed strongly in brain, spinal cord and dorsal root ganglions at 18 dpc
+Expression in early stages of embryogenesis. Expression begins in the posterior region of early primitive streak-stage embryos and after it spreads into the embryonic ectoderm up to a sharp rostral boundary at the base of the developing headfolds. Expressed transiently in the newly formed mesoderm. Expression is down-regulated during somitogenesis. The expression is highly restricted during gastrulation and neurulation, both temporally and spatially
+Expressed in the nervous system and epithelial tissues of the trachea at 14.5 dpc
+Expression begins at the start of neurulation (stage 13), followed by a gradual increase in expression from stages 16.5 to 26.5, after which expression levels are maintained through to stage 35
+Expressed in the first days following fertilization, but not in mature seeds
+Expressed at the posterior ectoderm except for the dorsal midline in gastrulae (PubMed:28716930). During neurulation, expression diminishes so as to become restricted to the lateral neural plate border (NPB) and neural crest (PubMed:28716930)
+Detected in 28- and 75-day-old mouse testes. No expression detected at 21 days
+Expressed both maternally and zygotically. Expressed at low levels in oocytes, with expression increasing rapidly during gastrulation and peaking during late gastrulation before declining through neurulation
+In underground tissues, observed in root tips and differentiated portions of primary roots, as well as in lateral root primordia
+Low-level expression detected in 17.5 dpc embryos but not in embryos earlier than 15.5 dpc
+Expressed in the procambial cells and the developing vascular system of embryos, roots and shoots. Expressed during the early stages of revascularization after cutting experiment
+In the intestine, expression decreases gradually from 20 dpc and finally becomes undetectable after weaning around 24 days after birth
+Preferentially expressed during seed development
+Expressed in the epidermis throughout development (PubMed:21575913). Also expressed in the seam cells, which are specialized epithelial cells that secrete the cuticle, as well as in the excretory cell, and the amphid and phasmid socket cells (PubMed:21575913)
+Expressed in promastigotes
+In the brain, highest expression at 16 dpc to 18 dpc. Expression decreases from 20 dpc onward
+Detected in the brain as early as embryonic day (E) 11.5. The level was low until 12.5 dpc, but promptly elevated to a peak 7 days after birth. Thereafter, it declined somewhat and reached a steady-state level in adulthood. These changes in BACH expression were approximately reflected in the palmitoyl-CoA hydrolyzing activity in the developing mouse brain, and the time course was quite similar to that of microtubule-associated protein 2 (MAP2) expression. Induced during embryogenesis in association with neuronal differentiation, and persists after terminal differentiation into neurons in postnatal stages, resulting in the constitutive high expression of BACH in the adult brain in a neuron-specific manner
+Constitutively expressed during development (at protein level)
+Expressed early in development at low levels and up-regulated late in development. The high levels during culmination is dependent on srfA. The late induction after 24 hours of development was not observed in srfA-null strains
+Expressed zygotically. Shows higher zygotic expression than hes4-A/hairy2a
+Expression occurs in the embryonic hypodermis, pharynx and intestine, as well as in postembryonic epithelia, including the vulva, uterus, spermathecae, pharynx, intestine, hindgut, hypodermis and male tail
+Expressed in sporozites
+Slightly induced in leaves during senescence
+Expressed in male meiocytes and tetrads
+Found in elongating hypocotyls
+Weakly or not expressed in neonates and young adolescents. Then, it is strongly expressed postmeiotically. Accumulates in gametocytes as they approach the lumen of seminiferous tubules and thereafter
+Most abundant at 2 hours after induction of meiosis, at the time of premeiotic DNA synthesis. Found at much lower levels before and after this time
+Expressed at constant levels throughout embryo and larval development (at protein level)
+Expressed between 3-12 hours of embryonic development
+First detectable at 16 hours post-fertilization (hpf) in trigeminal and Rohon-Beard neurons. At 18-24 hpf, it is also weakly expressed in discrete cell clusters in the hindbrain, in the anterior lateral line/acoustic ganglion and in spinal motor neurons
+Expressed in fetal kidney, fetal lung, fetal liver and at low levels in fetal brain
+Expressed at the comma stage in pharyngeal muscles and the developing intestine (PubMed:19855022). Detected in all larval forms and adults, but is most abundant in the embryonic stage (PubMed:8510930). At the two-fold stage of embryogenesis, mainly it is expressed in the intestine (PubMed:20711352). During late embryogenesis, before hatching, it is expressed in the posterior pharyngeal bulb and the pharyngeal-intestine (PubMed:20711352). After the L1 stage of larval development it is expressed in the anterior part of the animal in tissues including the pharynx, body wall muscle and ventral cord neurons (PubMed:20711352)
+Expression increases steadily during postnatal rat brain development
+Transcription is reduced upon fruit development; as fruit ripens and chloroplasts differentitate into chromoplasts transcripts increase again. Protein levels also increase in chromoplasts (at protein level)
+Specifically present in asexual blood stage parasites. First detected in the trophozoite stage, 30-40 hours post-invasion (HPI) and the proteins reaches peak expression in schizont stage, 40-48 HPI
+Expressed at high levels in the embryonic brain at 13.5 dpc (PubMed:18675896, PubMed:22586092). Expression decreases thereafter, reaching the lowest levels at postnatal day 14 and remaining unchanged in adulthood (PubMed:18675896). Expressed in the developing heart at 13.5 and 16.5 dpc, during the transition from spongy to compact myocardium (PubMed:17198697)
+At Carnegie stage (CS) 14, widely expressed throughout the telencephalon and mesencephalon, with a sharp cutoff at the midbrain-hindbrain boundary. At CS16, found in the lamina terminalis and the floor of the telencephalon. At CS16-CS19, in the developing eye, strongly expressed in the retinal pigment epithelium layer and more weakly in the neural retina, not expressed in the optic nerve itself (at protein level). Retinal expression peaks between CS19 and CS21 and decline in older fetuses. At CS22, detected in the choroid plexus, the dorsal thalamus, and the roof of the mesencephalon. In the developing nasal structures, expressed in the olfactory epithelium of the nasal pits at CS18
+Detected from 13.5 dpc to the first day after birth in cortical neuron progenitor cells in the ventricular zone and in postmitotic neurons in the cortical plate
+Expressed during all phases of oocyte maturation; localized at the meiotic spindle and spindle poles during meiosis
+Specifically expressed form 9.5 dpc to 12.5 dpc in limb buds
+Most abundant mRNA species from cotyledons at early stages of development, but the encoded protein does not accumulate in cotyledons
+In the myoblast C2C12 cell line, expression is increased upon differentiation into myotubes
+Expressed in embryos and in adult animals
+Expression starts at postnatal day 20 and increases thereafter
+Peak dihydropterin deaminase activity is observed in late pupae and newly eclosed adults, which correlates with the time of eye pigment formation
+Rapidly induced following seed germination, especially in tender cotyledons
+Higher transcript levels are detected in freshly germinated mycelium, with less expression seen in ungerminated conidia and cultures near stationary phase
+Expressed in endothelial cells of the lung at 12 dpc
+Expressed in fetal brain and lung
+First expressed at stage 10/11 of gastrulation. Higher levels found at stages 23/24 and 60-62. In the intestine, expression increased during metamorphosis (stage 62/64) and then, decreased. In the tail region, highest levels were found at the time of tail resorption. Activated, but at low levels, at stages 56-58 of hindlimb development
+Increases during G2/M phase compared to interphase. Protein level decreases when cells exit mitosis, probably due to degradation
+Expression in pubertal testes is first detected at day 12 coinciding with the onset of prophase I of meiosis (at protein level). Expression in spermatocytes first detected during zygotene when synapsis is initiated and persists on synapsed regions of homologous chromosomes until diplotene. In pachytene oocytes expression is also localized to synapsed chromosomes
+Only expressed in sentinel 'S-cells'
+After fertilization, expressed at the animal pole. Expression becomes restricted to the non-neuronal ectoderm of the embryo with progression through gastrulation and neurulation. Expression is observed only in the most superficial cellular layer of the embryo, being absent from the neural plate At later stages, expression is restricted to tissues with an epidermal fate
+Expressed both maternally and zygotically. Expression observed at the 4 cell embryo in posterior blastomeres. Detected in all descendants of EMS and P2 blastomeres. During gastrulation and morphogenesis expression is seen sporadically in all major cell lineages except the germ line
+Highly expressed in pachytene spermatocytes during spermatogenesis
+Expressed both maternally and zygotically throughout the cleavage, gastrulation and somitogenesis stages
+Maternal protein which is distributed within an animal-to-vegetal gradient in the embryo. Present from the egg stage onward and throughout the entire development
+Preferentially expressed in the S and G2 phases. Expressed in actively dividing cells: root and shoot apical meristems, leaf primordia and emerging lateral root meristem. Expressed in light-grown seedlings from 1 up to 7 days after germination with a peak at 2 and 3 days. Observed in late guard mother cells (GMC), newly formed guard cells, and immature stomata, thus being expressed just before and after the symmetric division of stomatal differentiation (PubMed:20675570)
+Specific to late spermatogenesis
+Expression starts 11 hours post-fertilization (hpf) in the presumptive forebrain and becomes restricted to specific clusters of cells in the telencephalon and diencephalon at 24 hpf. Expressed in the neurons of the postoptic commissure at 30 hpf
+Barely detectable in asexual spores (conidia), disappears after germination, and starts to accumulate 10 hours after spore inoculation, throughout growth and conidiation
+Expressed from early embryonic stages through to late pupation
+Expressed in the early planula stage of Nematostella in single cells of the ectoderm. These cells are thin and elongated as would be expected of developing nematocytes. In the later stages, the expression expands to an additional domain of large thick cells in the pharynx. The size and richness of vesicles suggest that these cells are not nematocytes but gland cells, and in the polyp stage, they become the major expression domain of this protein
+Detected at 20 dpc, between P0 and P10, and in adult in anterior olfactory nuclei, in cortex entorhinal region, hippocampal C3 and dentate gyrus, basal telencephalon septum, hypothalamus ventromedial and preoptic nuclei and dorsal thalamus medial habenula. Detected at 20 dpc in cortex cortical plate. Detected between P0 and P10, and in adult basal telencephalon amygdaloid complex, and diencephalon pretectum optic tract nuclei
+Expressed in some cells at the embryonic stage (260-280 min after the first cleavage) (PubMed:26218657). In hermaphrodites, expression is first detected in gonads in L2 larvae and is limited to the distal tip cells (DTCs), then continues in DTCs throughout L4 larval stage and becomes faint or absent in adults (PubMed:10376599). Also expressed in muscle cells throughout development (PubMed:10376599). At the larval stages, expressed in some head neurons, intestine and excretory cells (PubMed:26218657)
+Expressed during apoptosis
+Expressed in vegetative and early developing cells, its level decreases at about 10 hours of development
+Expressed during the asexual blood stage; expression begins in trophozoites and peaks in schizonts and merozoites (at protein level)
+Mainly expressed in vascular tissues during the mature stage
+Present in hair follicles at all stages of development
+Up-regulated during oligodendrocyte differentiation
+Expression increases gradually from 18 dpc through adulthood
+Expressed from 2 to 6 days after imbibition
+Expressed in the ventral spinal cord as early as 9.5 dpc. Expression declines to undetectable levels by 10.5 dpc and reappears in a narrow zone within the ventral neuroepithelium of the spinal cord. In the 14.5 dpc spinal cord, expressed in the oligodendrocyte progenitors of the ventral ventricular zone, but not dorsal root ganglia Schwann cells. Also expressed scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. By 15.5 dpc, dispersed throughout the gray matter, with little or no residual expression in the ventricular zone. In the postnatal brain, present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Expressed in the olfactory epithelium from 11.5dpc onward
+Expressed from the egg stage to the swimming tadpole, with maximum levels observed in the stages from egg to gastrula. At gastrulation distributed uniformly in embryonic ectoderm and involuting mesoderm, and expression gradually localizes to the nervous system. At early tadpole stages expressed in the CNS, eye, branchial arches, kidney and somites
+Detected in testis from 18 days onwards. In developing spermatazoa, expressed from the round spermatid stage through to the terminal stages of spermiogenesis, when expression declines
+Embryos and adults
+Expressed in the brain in the newborn
+Widespread and uniform expression in whole embryo at all development stages (PubMed:10665934). Expressed in cell stages of the first meiotic division and thereafter (PubMed:10665934). Initially expressed at day 14 with consistent expression thereafter to day 365 (PubMed:18684731)
+Expressed in the thymus with increasing level, approximately 4-fold, from 15.5 dpc to 16.5 dpc, constant level from 16.5 dpc to birth, then decrease to a low level by P30. Expressed at 13.5 dpc in the dorsal root ganglia of the peripheral nervous system and the trigeminal ganglion of the metencephalon and at relatively low levels in the cerebral cortex; no significant expression was observed prior to 13.5 dpc. Expressed in the spinal cord at 19 dpc, but weakly detected in the lung and the liver
+Expressed at early stage of flower development in floral meristem and at later stage in lemma, palea and carpel primordia
+Expressed in the seam cells, and in the hyp7 syncytial hypodermis in the mid-L4 larval stage (PubMed:24569038). Not expressed in the cells of the developing vulva (PubMed:24569038)
+Expressed in the otic placode at 8.5 dpc (at protein level) (PubMed:33795231). Between 10.5-12.0 dpc, expressed in various regions of the developing ear, including the cochlear duct, endolymphatic duct and the vestibule, but not in the region which gives rise to the posterior and anterior semicircular canals (at protein level) (PubMed:33795231). Expressed at 8.5 dpc in the cardiac crescent, the atrium and the inflow tract (IFT) (PubMed:15459098). Expressed at 9.5 dpc in the otic and optic vesicles, facial region, septum transversum, bilateral nephrogenic mesodermal cords, ventral body wall mesoderm caudal to the forelimbs, pharyngeal arch mesenchyme that contains neural crest cells, including those migrating into the outflow tract (OFT), septum OFT, inner curvature, atrioventricular canal (AVC) and IFT of the heart (PubMed:7920656, PubMed:8853987, PubMed:15459098, PubMed:33795231). Expressed in a continuous stripe of mesenchyme in the ventro-lateral body wall between the fore and hind limb buds at day 10.5-11.5 dpc (PubMed:16222716). At 12.5 dpc, expressed in the trigeminal ganglia, facial regions, retina and limb bud mesenchyme (PubMed:8853987). In later stages, found in ear pinnae, the milk line, lung mesenchyme, body wall, genital ridge and developing nervous system (PubMed:8853987, PubMed:33731112). Expressed in proliferating retinal pigment epithelium (RPE) cells at 14.5 dpc, and continues after birth, but diminishes by postnatal day 90 (PubMed:28910203). Expressed in melanocytes of postnatal day 3 hair follicles (PubMed:26486273)
+Is enriched in the vegetal half of the oocyte. In stage II oocytes is present uniformly in the cytoplasm; at stage III, it is concentrated towards the vegetal pole and finally clearly accumulates in the vegetal cortex by stage IV and V. It is expressed throughout the oocyte cytoplasm, forming a vegetal-to-animal gradient. After fertilization, persists in the yolky endodermal cells until mid-blastula-transition (MBT). At MBT, is abundant in the large endodermal cells. By the gastrula stage, this endodermal core is found in the center of the embryo. At stage 12, is also independently expressed in the late dorsal blastopore lip. This expression continues in the midline of the neural tube and finally regresses to the tip of the tail. At stage 30 expressed in the floorplate. At tailbud stage, expression is also detected in the pronephros and pronephric duct
+First expressed at the late blastula stage (stage 9). Most abundant during gastrulation, with levels peaking in mid-gastrula embryos (stage 12) before declining rapidly at the end of neurulation and becoming barely detectable in the late tailbud-early tadpole stage
+Expressed both maternally and zygotically. Expressed at all stages of oogenesis except in previtellogenic oocytes. During embryogenesis, weakly expressed as early as the one-cell stage shortly after fertilization, and remains at a relatively uniform level throughout embryogenesis, persisting at least until stage 35 (early tadpole)
+Undergoes developmental regulation during mammary gland development
+Induced in the connective tissue of stamens shortly before dehiscence
+Highly expressed at the G1/S transition
+Expressed throughout pituitary development. Not found in 8 dpc embryos but seen in embryos at 8.5 dpc in the region of the first branchial arch and ventral portion of the caudal-most region of the embryo. At 9.5 dpc observed in the hindlimb buds, maxillary and mandibular components of the first branchial arch and Rathke pouch and the pattern of expression continues through 10.5 dpc at 11.5 dpc also found in ventral mesenchyme covering the abdominal cavity and in the nasal epithelium. At 17.5 dpc expressed in derivatives of the first branchial arch, including tongue and mandible as well as duodenum, salivary glands, nasal epithelium and condensing cartilage in the hindlimbs
+Expressed during the asexual blood stage; expression begins in mid to late trophozoites and continues in schizonts (at protein level)
+Expressed in embryonic testis at 16.5 dpc (at protein level). Expressed at low levels in type A and B spermatogonia, increases 5-fold in spermatocytes undergoing meiosis (pachytene spermatocytes), and then decreases again in round spermatids. Expressed at low levels in testes in young mice, peaks from postnatal day 14 to day 29 with the onset of puberty andpersists in adulthood (at protein level)
+Levels remain unchanged during postnatal development (at protein level)
+Expressed in the pharynx from three-fold stage embryos to adulthood
+In neural plate stage embryos, expressed in precursors of primary sensory and motor neurons. At tailbud stages, expression persists in neural tube and is up-regulated in anterior structures such as eye and brain, and in branchial arches
+Expressed from the embryonic stage to adulthood
+During embryonic liver development, expressed in the islands of cells, consistent with an expression in hematopoietic precursors
+Detected in the theca and granulosa layers of the ovarian follicle in the white follicle (WF), F1, F3, F5, and postovulatory follicle stages
+Expressed in the seed coat of developing seeds from 2 to 6 days after fertilization
+Spermiogenesis
+Expressed zygotically from the early gastrula stage. Expression increases throughout gastrulation and remains high during the early neurula and tail bud stages
+Expressed both maternally and zygotically. Present in all embryonic stages including early cleavage stages, with levels decreasing slightly during gastrulation and neurulation (stages 10-20). Levels then increase at stage 30 and expression persists until stage 45
+Expressed in embryonic, early postnatal and adult brain, with expression up-regulated at postnatal day 4-8 and down-regulated in adults. Isoform 2 expression is up-regulated in adults
+Expressed in the developing brain and developing limb buds
+Expressed both maternally and zygotically. Also expressed at lower levels later in embryonic development, and in larvae and adults
+In adult testis, is strongly expressed only in Leydig cells. In testicular tumors, expressed specifically in Leydig cell tumors (at protein level). Expressed from 14 weeks until birth in fetal testis
+Expressed both maternally and zygotically. Expressed in all embryonic stages, with expression increasing during development
+Expressed in the lungs from 19 dpc, expression is increased at birth and at four weeks of age
+Expressed in fetal kidney, lung and liver
+Present at the G1/S boundary. Accumulates as cells progress from S to G2 into mitosis. Rapidly degraded during mitosis exit by CDH1-activated anaphase promoting complex/cyclosome (APC/C)
+Expressed during fruit ripening. Fruits harvested 140 days after full bloom show much higher expression levels than fruits harvested 20, 60 or 100 days after full bloom. Expression in fruits increases rapidly during storage and is highest on day 12, simultaneously with a dramatic fruit softening
+Expressed both maternally and zygotically. Expressed in oocytes (at protein level). Up-regulated during metamorphosis, peaking at stage 62 before dramatically reducing by the end of metamorphosis (stage 66)
+Expressed in the periderm of fetal skin from 16th week gestational age and in the granular and horny layers of the epidermis at 24th week gestational age and thereafter (at protein level)
+Is cell cycle-regulated; expression peaks in early S or G1 phase
+Expressed throughout development from the late embryonic stage (PubMed:18158917). Expressed in all larval stages, in H0-2, V1-6, and T seam progeny, and in the uterine seam cells (utse) during late larval stage L4 in hermaphrodites (PubMed:17933794). Expressed in some body wall muscle cells and some pharyngeal neurons (PubMed:17933794)
+Maximal expression during the erythroblast terminal differentiation
+Only detected in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs. The protein is present in SCVs from Nine Mile phase I strains, but its distribution in phase II strains was not examined (PubMed:8899704)
+First expressed at step 11 of spermatogenesis in the elongating spermatids, and subsequently incorporates into the flagellar principal piece of the sperm
+Expressed throughout development, highest expression in first and second instar larvae and adults
+Expressed in the frontal neocortex, glanglionic eminence, mesencephalon and cerebellum at 13.5 dpc. More prominently expressed in the developing cerebral neocortex and mesencephalon at 15.5 dpc and in the cortical plate and in the remnant of the ventricular zone at 18.5 dpc
+Expressed during vegetative growth and sporulation
+Expressed essentially during the stationary growth phase when OPG synthesis has stopped
+Firstly detected during early seed maturation, at 9 days after anthesis (DAA), peaking at 18 DAA, before falling sharply during late maturation
+Synthesized and released from follicular epithelium 18-24 hours after a blood meal
+Found in the neuroepithelium of the meninges at 8.5 dpc, and in the roof plate of the rhombencephalon at 9.5 dpc. In 12.5 dpc embryos, it is ubiquitously expressed, with a pronounced expression in the neuroepithelium of brain vesicles, the neural tube, the ganglia and the neural layer of the retina
+Expressed in vegetative cells. Expression rises within 6 hours after the initiation of development and gradually decreases following the mound stage
+Specifically presents on the surface of stage V male gametocytes (at protein level) (PubMed:12106866, PubMed:30297725). Not expressed in gametes or asexual parasites (PubMed:12106866). Expression peaks in stage III/IV gametocytes, then sharply declines in gametes (PubMed:12106866)
+At the 10-somite stage, barely expressed in the paraxial mesoderm. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit at somite 1
+Induced at early aggregation (6 hours) and maximally expressed at the mound stage (9-12 hours), level of expression peaks again during the slug stage (18 hours) and declines at culmination
+Expressed in growing oocytes and early embryos
+Highest expression occurs in four-day-old plants and declines as plants develop further
+Expressed both maternally and zygotically (PubMed:16251381). Expressed through embryonic and larval stages (PubMed:16251381). During embryonic stages 9-11, expressed in the developing anterior midgut and amnioserosa (PubMed:16251381). Expressed in the salivary glands from embryonic stage 12 onwards (PubMed:16251381). During embryonic stages 12-13, still expressed in the amnioserosa region (PubMed:16251381). In third instar larvae, expressed ubiquitously in wing, with increased expression in the notum and ventral wing pouch, leg and haltere imaginal disks (PubMed:16251381). In eye-antennal imaginal disk, expressed in the presumptive eye region only (PubMed:16251381). Isoform A: Expressed in trachea, midgut, salivary gland, hindgut, central nervous system and Malpighian tubules (PubMed:30158631). Isoform B: Specifically expressed in the salivary gland (PubMed:30158631)
+Expression in the cerebellum increases dramatically after the first postnatal week (PubMed:18490449, PubMed:30837646). Selectively expressed in brain at P21, and not expressed in any other tissues tested including thymus, lung, heart, liver, spleen, kidney and testis
+Expressed from the proximal end of interzone II to III to the proximal end of root nodules produced after inoculation with Sinorhizobium meliloti (at protein level)
+Induced by seed imbibition with a peak at day 5 to 7. Decreases after illumination but still detectable 5 days after illumination (PubMed:10212254)
+First detected at days 7.5-8 dpc, when it is weakly expressed around the developing mesodermal cells. At day 10.5 dpc it is detected in the heart and the condensing somites, and at day 14.5 dpc it is present in the choroid plexus, the cochlea, the terminal bronchii of the lung, the heart, the skin, and in the cartilage primordium of the developing skeleton as well as in the interdigital spaces. Strong staining is seen in the condensed mesenchyme forming the edge of the developing teeth budding into the branchial arch and coinciding with the basement membrane that underlies the stratified squamous epithelia in the oral cavity
+In the embryo, stronger expression at 15.5 dpc than at 10.5 dpc or 19.5 dpc. Expression decreases after birth although significant expression remains associated with some neuronal structures at P10
+First detected at the blastula stage (stage 8). Expression peaks through the mid-blastula (stage 8.5) to early gastrula (stage 10) and then decreases during gastrulation
+Up-regulated in activated B lymphocytes
+Expressed in both embryos and adult fish, and the expression is specifically in fast skeletal muscle
+Up-regulated during ripening, with a highest expression in fully mature red fruit
+Expressed in testis and ovary at 15.5 dpc (PubMed:20339383). May be differentially expressed during spermatogenesis. Detected first at P12, the early stage of spermatogenesis. Levels considerably increase at P16, corresponding to the development of pachytene spermatocytes (PubMed:23212345)
+Detected in the first branchial arch of embryonic day 11 (11 dpc) embryo, and subsequently in the myotomes and the dorsal root ganglia in developing somites from 11.5 dpc through 13.5 dpc, but not in the brain. However, at 15 dpc, 18, dpc, 21 dpc and P0, highly expressed in the brain
+Peak of expression in 3- and 4-day-old seedlings
+Expression specific to the G2 and M phases
+Expressed throughout the embryo including the shield. Strongly expressed in notochord and head regions from the bud to somite stages. Expressed in early born neurons in the telencephalic nucleus, the nuclei of the tract of the post-optic commissure and of the medial longitudinal fasciculus, and in segmental clusters of neurons in the hindbrain
+Not expressed at early stages of plant development. First detected in leaves 4 weeks after germination, and expression levels are increased when the plant reaches the reproductive stage
+Expression detected from stage 2 in the primitive streak. During subsequent stages of primitive streak formation (stages 2-4), expression seen in the extraembryonic mesoderm and lateral mesoderm, and weakly in the elongating primitive streak. Concomitant with the onset of node and streak regression (stage 5), the expression in the lateral mesoderm extends to the anterior limit of the mesodermal cell layer. After gastrulation, continuously expressed in the heart-forming region and also detected in other regions such as the allantois, optic vesicle, hindbrain and ventral neural tube
+Expressed in CD34-positive erythrocyte progenitor cells. Down-regulated upon differentiation
+Expressed throughout development; expression peaks at embryonic stages 8-16
+Expressed weakly in the eye from as early as 13.5 dpc, with ocular expression up-regulated postnatally. By 10 weeks, expressed strongly in the lens epithelial cells and weakly in lens fibers. In adult, expressed in eye, brain and testis
+Expressed both maternally and zygotically, present throughout development. Highest levels are found during oogenesis and in early embryos
+Detected in unfertilized oocytes; expression continues in preimplantation embryos though to the blastula stage (at protein level) (PubMed:24991885). In testis, detected in very early spermatogonial germ cells with expression continuing through to the elongated spermatid stage (at protein level) (PubMed:24435972, PubMed:24991885). Weakly expressed in spermatozoa (at protein level) (PubMed:24435972). Not detected in spermatozoa (at protein level) (PubMed:24991885)
+In the developing skin, expression is not be detected prior to hair follicle induction (13 dpc). Expression is initially detected in the inner root sheath (IRS) of developing vibrissae follicles at 16 dpc and later in the developing IRS of 18.5 dpc pelage follicles
+In crown roots, mainly expressed after crown roots emergence but barely in crown root initials
+Expressed prior to the late culmination stage, in the prespore region
+Expressed in fetal brain and kidney
+In developing teeth, expressed in ameloblasts during transition and maturation stages (PubMed:10863090, PubMed:10690663, PubMed:19578120). Expressed weakly in odontoblasts (PubMed:10863090). Not detected in odontoblasts (PubMed:19578120). Detected in the epithelium surrounding the erupted first molar (PubMed:10690663)
+Expressed during parasite asexual blood stages, in trophozoite and schizont stages
+Highly expressed at 7 dpc and decreases rapidly thereafter
+Present in a small patch of cells on the innermost side of the hypocotyl hook of the germinating seedling, in the subapical pith cells of plants growing vegetatively, in a similar zone of expanding cells both in developing inflorescence stems, and below mature flowers and elongating siliques (PubMed:11743113). Accumulates in the pollen tube nucleus during pollen tube growth through the pistil (PubMed:23791732)
+During early nervous system development, robust expression was observed in the open neural plate and later in the dorsal neural tube and much of the brain. Also present in the developing heart primordia and the sensory placodes
+Highly expressed in unfertilized eggs, late planulae, primary polyps, and adult females (at protein level). Not expressed in adult males (at protein level). Consistant with protein expression, transcripts are highly expressed in unfertilized eggs, blastulae, gastrulae, early and late planulae, metamorphosing planulae, and adult females. Its expression is moderate in primary polyps. Its expression is very low in juvenile polyps, and adult males
+Expression is first detected in the marginal zone of the blastoderm. Expression becomes more apparent at the germ-ring stage. In the early gastrula, expressed only in hypoblast cells of the germ ring. At mid-gastrula stage, expressed in ventrolateral mesoderm and is subsequently restricted to the segmental plate at late gastrula stage. At the segmentation period, expressed in the presomitic mesoderm including the tailbud. Expression is also detected in the adaxial cells in the vicinity of the presomitic mesoderm
+Expressed in neuronal tissues of 14.5 dpc mice
+Expressed in posterior regions at the comma stage of embryogenesis, during larval development and in adults
+Expressed only during spermatogenesis
+Expression most important during germination, it decreases during development
+Transcripts are highly expressed in young, immature-green fruit, but turned off early in the ripening process. By contrast, protein levels seem stable throughout fruit ripening
+First observed in the distal and middle regions of cotyledons of heart-shaped embryos. Later localized in bending cotyledon, and mature embryos, but no signals were detected in the presumptive shoot apical meristem (SAM) and the boundary region during embryogenesis. Expressed during ovule development (PubMed:25378179)
+Down-regulation after 14.5 dpc is critical for cardiomyocytes to undergo normal developmental hypertrophic growth in early postnatal life
+Expressed in chordonotal neurons during their differentiation, after neuronal specification but before cilium formation. Also expressed in the non-ciliated mesoderm of stage 12 embryos
+It is first expressed in early neurula embryos (about stage 15) in a bi-lobed pattern at the front of the embryo (this corresponds to the presumptive heart mesoderm). By the end of neural fold closure it is highly expressed in the presumptive heart region. By stage 26-27 (at which heart differentiation begins) its expression can be clearly seen in the heart and the level in embryonic heart decreases at later stages of development. As expression within heart declines low level expression is seen in the foregut and the pharyngeal region
+Expressed ubiquitously at very low levels throughout embryonic development. Higher levels of expression seen in inner cell mass and heart
+Primarily detected in striated muscle structures of the 14.5 day embryo, including all major muscles in the skeletal structures, cardiac muscle, diaphragm, and the smooth muscle of the lung and gut
+Detected in optic cup in 5.5 weeks-old embryos. Expressed in retinal pigment epithelium, cochlear and vestibular neuroepithelia, and olfactory epithelium at 8 weeks. At 19 weeks, present in both pigment epithelium and photoreceptor cells. At 24-28 weeks, expression in pigment epithelium and photoreceptor cells increases. Present in pigment epithelium and photoreceptor cells in adult
+Maternally and zygotically expressed. Expression declines at the mid-blastula transition
+In ovules, mostly observed in the female gametophyte (FG) including the synergids, which showed a ring shaped localization around their nuclei, and throughout the pollen tube (PT)
+Expressed throughout development of the stigma and style, and then decreases at 6 days after anthesis
+Found during somatic and zygotic embryogenesis
+Found to be expressed in fetal brain. Down-regulated in fetal Down syndrome (DS) brain
+Expression increases gradually as nodules develop and then remains constant from 4 weeks to 2 months. Expressed at lower levels in senescing and non-fixing nodules
+Maternally and zygotically expressed. Expressed in the embryo at the 256- and 512-cell, sphere and epiboly stages. Expressed in ciliated tissues, including Kupffer's vesicle, otic vesicle, pronephric duct and floor plate of the neural tube. Expressed in the floor plate and chordoneural hinge at 24 hpf. Expressed in the anteriormost tubules adjacent to the glomerular region at 36 hpf. Expressed in the pronephric tubules from mid-somitogenesis through 48 hpf
+Expressed during embryogenesis before differentiation of excitable tissues
+At 9.5 dpc, expression is only observed in the tailbud and the hindgut. At 11.5 dpc the expression is found at sites of bone formation, i.e. surrounding mesenchymal condensates in the fore- and hindlimbs, the nose, the maxilla, and the other parts of the jaw. At 13.5 dpc, detected in perichondrium and around developing skeletons, but barely detectable in mature osteoblasts. At 14.5 dpc it is strongly expressed in the enteric nerves of the digestive tract and the bladder. Expression is also observed surrounding the main branches of the alveoli and surrounding sites of bone formation in skull and trunk
+Is detected in unfertilized eggs (at protein level). At mRNA level, its highest expression level is observed in the unfertilized eggs. Starting from blastula stage, its expression gradually drops (in gastrulae, early planulae, planulae, metamorphosing planulae, primary polyps, and juvenile polyps (2 and 4 months old)) till the metamorphosis stage and peaks again in the adult females (a small increase is observed in adult males)
+Highly expressed during the first week after birth
+Highly active in root primordia, leaf primordia and flower primordia
+Expressed at the early stages of embryo development, up to the late heart stage
+Expressed both maternally and zygotically. Ubiquitously expressed during embryogenesis
+Weakly expressed in the dorsal root ganglion neurons at 10.5 dpc, the expression increases at least until 15.5 dpc (PubMed:22326227). Expressed in the developing ganglion cell layer of the retina at 12.5, 13.5 and 16.5 dpc (PubMed:8632990). Expressed in the outer margin of the retina at 15.5 dpc (PubMed:10414983). Expressed in embryonic heart from 13.5 dpc until birth (at protein level) (PubMed:18368538). Expressed in the developing spinal cord from 13 dpc until postnatal day 1 (PubMed:8290353, PubMed:8537352). Expressed in retinal ganglion cells (RGC) at 13.5 dpc, peaks at 15.5 dpc, declining later in development (PubMed:8637595)
+Expressed in cardiomyocytes of the atrium and ventricle of the heart in embryos at 10.75 and 13.75 dpc
+Detected in posterior lateral mesoderm, head mesenchyme and the intermediate cell mass in embryos 24 hours after fertilization
+Expressed at high levels in embryos and larvae, low levels in adults and pupae show maximal expression
+Expressed widely from the 28-cell stage of embryogenesis and throughout development and adult life
+First expressed at stage 9, after the mid-blastula transition (MBT). Expression is highest at stage 10.5 and remains constant until the tadpole stage (PubMed:17475571). First detected at stage 10.5, expression increases gradually until the tadpole stage (at protein level) (PubMed:21177533). Highly expressed in the epidermal ectoderm at the neurula stage (PubMed:21177533)
+Ubiquitously expressed at very high levels in embryo. Expressed at low levels during larval stages, and at higher levels in female adults (at protein level)
+Expressed both maternally and zygotically. Abundant in ovaries, early embryos and adult females, but reduced in adult males
+The expression of this protein depends on the parasite life cycle. It accumulates to a higher level in the extracellular promastigotes than in the intracellular amastigotes
+Expressed in epimastigotes, amastigotes and cell derived trypomastigotes and in metacyclic trypomastigotes (at protein level)
+Detected in the presumptive ectoderm at the late blastula stage. During the gastrula stage, expression refines to the ventrolateral ectoderm and the dorsal-midline ectoderm. Expressed in primary neurons during the segmentation stage, with strongest expression in primary motoneurons and interneurons and lower expression in Rohon-Beard neurons. The expression domain is restricted to regions posterior of rhombomere 4. During the late segmentation and pharyngula stages, expression decreases in an anterior-to-posterior direction and is largely absent by 48 hours post-fertilization
+Expressed at late embryonic stages between 18.5 and 19.5 dpc in intestine and liver
+Expressed in embryonic nasal epithelium, dorsal root, trigeminal ganglia, brain and liver. Within the brain, expression is highest in the ventricular zone and decreased in structures containing migrating and postmitotic neurons (at protein level)
+Expressed preferentially during the sexual cycle and essential for normal sexual development
+Expressed specifically in prestalk A (pstA) cells
+Expressed in embryonic brain at 14 dpc, and thereafter (at protein level) (PubMed:8508921). Expressed in embryonic brain at 14 dpc, and thereafter (PubMed:8508921)
+Early expressed at stage two (plastochrons 7 and 8), when the floral meristem comprised a loaf-shaped bulge of cells. Expression was in the dorsal region of the floral meristem. At stage four, when sepal primordia had emerged around the meristem dome, expression could be seen in the dorsal sepal primordium. At stage five, expressed in emerging dorsal primordia of whorls two and three. In older flower buds (stages seven and eight), expression was found mainly in the dorsal petals and staminode
+Detected in 22-week old testis
+Expressed in the embryonic testis
+Detected in the brain as early as embryonic day 18, but expression increases dramatically after the third postnatal week
+Ubiquitously expressed in early embryo with a more restricted expression in later embryonic stages and in young larvae. Expressed in dividing cells including ventral nerve cord neuroblasts, vulval precursors, hypodermal seam cells and in the Q lineage. No expression in adults
+Blastoderm
+Expressed during egg-laying cycle in the hypothalamus and pituitary. Expression increases from the pre-laying period to the peak laying period reaching its highest level in the peak laying period and then decreases in the ceased period (PubMed:25146222). Expression is up-regulated in the pituitary gland during egg-laying period and down-regulated during ceased period (PubMed:25049869)
+Expressed in 4-cell embryo, morula and blastocyst. At 7.5 dpc, detected in the epiblast. At 10.0 dpc, expressed in the primordial germ cells. Expression decreases at 12.0 dpc in the embryonic gonads. At 14.5 dpc, expression is restricted to testis. 6 days after birth, still detected in primitive type A spermatogonia. Expressed in undifferentiated embryonic stem cells, but expression rapidly decreases upon differentiation
+In the developing tooth from 8-day-old mice it is expressed in secretory-stage ameloblasts, follicular cells, odontoblasts, and osteoblasts (at protein level)
+Expressed in the larva, in the pupal wings and the adult fly (at protein level). High levels of expression are found in larval hemocytes and garland nephrocytes (at protein level)
+Expressed in the mother cell compartment from T5 of sporulation
+Accumulates throughout young developing leaves, before being confined to the vasculature of older leaves (PubMed:19837869). Expressed during seed coat development, reaching peak expression late in differentiation at 10 days post anthesis (DPA) (PubMed:21518777)
+Expressed primarily in roots of young seedlings and later expressed in aging cotyledons, mesophyll cells of hydathodes on leaf margins, vascular tissue and trichomes of senescing rosette leaves. Also detected in young lateral roots and in mature pollen grains
+Expression in dentate granule cells of the hippocampus at postnatal day 7, with disappearing expression in dentate granule cells as early as P14
+Expressed maternally. Expression declines during oocyte maturation
+Strongly expressed throughout embryogenesis with a maximum from 8.5 to 13.5 dpc
+Transiently expressed during germination, within 1 day after imbibition, especially in the epidermis and the aleurone layer. Later present in the epidermis of the radicle and the adaxial side of the cotyledons. In roots, confined to the pericycle cells and in the lateral root primordia (LRP), and declined at the time of lateral root emergence. Expression is greatly increased in leaves during leaf senescence
+Expressed at 13.5 dpc in developing muscle, limbs, trunk, and heart
+Expressed during interphase and metaphase
+Expressed during parasite asexual blood stages, at the ring, trophozoite and schizont stages and in free merozoites (at protein level)
+Expressed during meiotic prophase and becomes undetectable in metaphase I in spermatocytes and oocytes (at protein level)
+First observed in imbibed seeds. Mostly localized in hypocotyls during germination and in seedlings. In mature plants, confined to vascular tissues of leaves and roots. In flowers, expressed in the vascular bundle of the stamen filament and in the stigma, where the filament joins the pistil
+Expressed in both germline and somatic cells during oogenesis and spermatogenesis (at protein level)
+Expression appears in trigeminal ganglion and dorsal root ganglia from 15.5 dpc and increased through 18 dpc to reach a peak in newborn mouse postnatal day 1
+Highly expressed during early development and then ubiquitously expressed at very low levels at later larval stages
+Expressed in developing panicle, and in developing seed up to 15 days after flowering. Expression is reduced in the late stages of seed development
+Expressed during both bloodstream (BF) and procyclic insect (PF) life cycle stages
+Highly expressed in the gut, myotomes and brain, especially the midbrain and hindbrain, at 3 days post-fertilization (dpf)
+At 3 days-post-fertilization (dpf), expressed strongly in neurons in the ventral hindbrain and tegmentum and diffusely in the dorsal hindbrain and optic tectum. Also expressed in the diencephalon and the prospective olfactory bulb. Expression in non-spiny type-XIV tectal neurons is mostly diffuse. Over the next 7 days, as the dendritic arbor develops, expression becomes progressively more punctate, becoming localized to sites of synapse formation. At 4 dpf, expressed in the inner and outer plexiform layers of the retina and in the optic chiasm
+Expressed at all stages in the development of mast cells
+Expression increases between day 2 to 45 and is then stable from day 45 to 120
+Expressed almost exclusively in peripheral sensory neurons (craniofacial and dorsal root ganglia (DRG) sensory neurons), but also in trigeminal ganglia (TG) Me5 proprioceptive neurons and Mo5 motoneurons
+High expression in blastocysts
+Highly expressed in developing brain, spinal cord and attached dorsal root ganglia (DRG) (at protein level). At embryonic day 18.5 expressed in gray matter of spinal cord, diencephalons, hippocampus and parts of midbrain and hindbrain. At postnatal day 20 expression persists in spinal cord and brain. Expressed in embryonic heart
+Barely detectable at stage 52 in the ZW gonads
+Ubiquitously expressed in early embryos and becomes restricted to the vasculature in the mature embryo and at later stages of development (PubMed:19465596). Expressed in roots developing protophloem, up to the end of the transition zone, as well as in the root tip meristem (PubMed:23569225)
+Restricted expression to the primary root in young seedlings. Later detected in hypocotyl, leaves and flowers
+Expressed constitutively in either dark- or light-grown seedlings
+Mainly present during the light phase, and degraded in a proteasome-dependent manner in dark (at protein level)
+At 8 dpc, expression is limited to the developing central nervous system (CNS). From 9 dpc on detected in the ventral forebrain, pretectum, dorsal diencephalon, metencephalon, the ventral spinal neural tube, in the ectoderm of the developing mandibular arches and the developing hindgut
+High expression in proliferating myoblasts is strongly reduced in differentiated muscle cells
+Expressed maternally and throughout embryonic development through to the tadpole stage
+Expression begins around the pachytene stage of spermatogenesis
+Expressed in glomerular podocytes and tubules in the fetal kidney (gestational age 25 weeks)(at protein level)
+Not expressed during brain development
+First expressed at 80-100% epiboly with an anterior limit at the presumptive rhombomere 4 (r4) of the developing hindbrain. Continuous expression in, and posterior to r4 until the 1-somite stage. By the 3-somite stage, expression is up-regulated in r4 and down-regulated in r5 and r6. At the 10-somite stage, weak expression in and posterior to r7. By the 15-somite stage, expressed only in r4
+Expressed in the T cell, head neurons, posterior gut cells, hypodermal cells (hyp7, hyp9, and hyp10), and P blast cells (PubMed:16824957). During T cell division, expressed asymmetrically, becoming up-regulated in posterior daughter cells (PubMed:16824957)
+Expression level remains constant during early development. First localized during gastrulation to the dorsal presumptive neuroectoderm. At the end of gastrulation, detected in the dorso-anterior neuroectoderm. During neurulation, expressed as a band on both sides of the forebrain, and in the trunk lateral plate mesoderm. As development proceeds, expression in the trunk lateral plate mesoderm decreases but persists in the forebrain. Also expressed in the posterior unsegmented somitic mesoderm from late tail-bud stage onward
+Induced when aerial mycelia start forming, expression is maximal when sporulation starts
+Expressed during all stages of larval development and adulthood (at protein level) (PubMed:21055481). Expressed during embryogenesis (PubMed:33238150). Expressed in EA and EP endodermal precursor cells at the 16-24 cell stage of embryogenesis (PubMed:33238150)
+Expressed maternally. Expression peaks at stage I of oogenesis and remains fairly constant through to the end of oogenesis and, after fertilization, up to blastula. From blastula, through gastrula and neurula, expression declines significantly. May also be expressed zygotically since a low level of expression is detected up to the free-feeding tadpole stage (embryonic stage 42) (at protein level)
+Expressed at all stages where apoptosis occurs
+In flowers, expressed in anthers, pollen and developing ovules (e.g. in egg cells) (PubMed:17293437). In developing ovules, accumulates mainly in the micropylar region of the embryo sac (PubMed:27524487)
+Expressed in the inner pericarp of developing fruit at 20 to 126 days after flowering (DAF)
+In early embryos, expressed in all cells. Expression is higher during early stages and is reduced in late-stage embryos. Present in the one-cell stage zygote, indicating it is provided as a maternal product by the hermaphrodite parent. During larval stages, expressed in proliferative cell lineages, including the seam cells, intestine, P-lineage cells, somatic gonad, and germline. Also observed in a subset of non-proliferative tissues, including hypodermal cells (at protein level)
+Expressed in intestinal cells from larval through to adult stages (PubMed:23911329). Expressed in neurons during L1 larval stage (PubMed:29949773)
+Expressed in embryo at 8.5 dpc. Expressed in arterial endothelial cells of the pharyngeal arch artery and endocardium at 9.5 dpc, onward. Expressed in dorsal aorta, pharyngeal arch and primitive internal carotid arteries at 11.5 dpc. Expressed also in intersomitic, mesenchephalic, metencephalic and anterior choroidal arteries at 12.5 dpc. Expressed in the ventral neural tube of the embryo
+Expressed as early as 12.5 dpc in the neuroepithelium (ventricular zone). At 17.5 dpc, expression becomes more pronounced in postmitotic cells of the cortical plate (CP). Early postnatally (postnatal day 2 [P2]) and in the adult brain (P30) expressed both in the cortex and in the hippocampus
+During cerebellar development expression was low before postnatal day P6 and dramatically increased after P12
+In uterus, strongly expressed at proestrus, declines at estrus and disappears at diestrus. In oviduct, strongly expressed at both proestrus and estrus but declines significantly at diestrus. In uterus, highly expressed on day 1 of pregnancy but declines dramatically on day 2 and is not detected between days 3 and 7. In oviduct, highly expressed on days 1 and 2 of pregnancy but declines significantly on days 3 and 4
+In brain, detected first perinatally, with expression reaching maximal levels at postnatal day 9 (P9). In the developing nervous system, barely detectable until birth, and postnatally expressed in white matter tracks including the corpus callosum, external capsule, fimbria hippocampi and corticospinal tracts. In spinal cord, not detected until birth, and postnatally expressed in spinal white matter. In cerebellum, expressed only in cerebellar white matter cells, with expression detected first shortly after birth in the cerebellar peduncle and increasing progressively in the white matter tracts of the cerebellar lobes until P10
+Detected throughout the myocardial layer of the heart tube. Not expressed in the myocardium at 9.5 dpc but is present in epicardial cells and the pro-epicardial organ. At 10.5 dpc, expressed in the atrial and ventricular myocardia as well as the inter-ventricular septum. Continues to localize to the atrial and ventricular myocardia at 12.5 dpc as well as the ventricular trabeculae
+Expressed in developing veins of late torpedo, walking stick and bent cotyledon stage embryos
+Expressed during the entry into stationary phase resulting from glucose limitation
+Expressed in the germ plasm and the primordial germ cells (PGCs). At the onset of embryogenesis, maternal product is located in granules distributed throughout the cortex of the one-cell stage embryo. At 0.5 hour post fertilization (hpf) is expressed at the vegetal part of the blastomere. At 1 hpf expressed at the distal parts of the first two cleavage furrows. At 4 hpf expressed exclusively in PGCs. Expressed in PGCs during their migration and at their arrival in the presumptive gonade. At 5 days post-fertilization (dpf) still expressed in PGCs, albeit at a lower level
+Expression increases during neuronal development (at protein level)
+Expressed in fetal testis and ovary. In the developing ovary, detected at least from Carnegie stages (CS) 22/23. Expression seems to peak at 15/16 weeks post conception (wpc) (PubMed:34402903). In the developing testis, expressed at CS22/23 and until at least 19/20 wpc (PubMed:34402903)
+Transcribed specifically during sexual development
+In fetal brain exclusively in pontine nuclei. Expressed at 5 weeks of development, the stage at which optic fissure closure starts. Expression is maintained in the developing retina up to 8 weeks; after completion of fissure closure, it is restricted to the inner neuroblastic layer. Expressed in the cornea, lens, and retina at different developmental stages
+Synthesized in early stage 10 egg chambers. Cleavage generates S80, a 80 kDa species, during late stage 10 which is incorporated into the eggshell. During the latter stages of chorion formation, S80 is processed to a 60 kDa component, S60
+Expressed both maternally and zygotically. Abundant in early embryos and present in very low amounts at every stage of the life-cycle
+Levels remain constant during development
+Expressed during the asexual blood stage; expression begins in trophozoites and continues in schizonts (at protein level)
+Expressed both maternally and zygotically. Present in the unfertilized egg and in all embryonic stages up to the pluteus stage, followed by depletion of expression in the late embryo. Expression starts again just prior to metamorphosis in larva at 35 days post-fertilization (dpf). Also expressed in adults (at protein level)
+Minimal expression in oocytes and embryos prior to mid-blastula transition. Readily detected in the presomitic tissue from late gastrulae. By neurula stages, somitic expression is broader and also appears in developing neural structures and other anterior structures (eye anlage). By late neurula, the posterior expression is condensed into two stripes on each side, expression in the anterior tissues remains high in the developing eye. During tailbud stages, expression is still high in the eye vesicle, otic vesicle and other anterior regions, as well as the presomitic mesoderm. In the tadpole, highly expressed in the head, eye and otic vesicle, branchial arches and midportion of the somites
+Expressed maternally and throughout early embryogenesis. Highly expressed in tissues participating in prominent morphogenetic movements. Enriched in the animal hemisphere in early gastrula and the anterior region in late neurula. Expressed in the head region in the tailbud stage, particularly the optic vesicle, ear vesicle, olfactory placode and branchial arches. Expression is also weakly elevated in the somites, notochord and pronephros
+Expression is first detected at embryonic day 11, and higher amounts were detected at days 15 and 17
+At 14.5 dpc, widely expressed, including in neocortex, cerebellum, lung, liver, hindlimb, intestine, as well as forelimb, kidney and spinal cord vertebrae
+Expressed in the germinating embryo. Low levels in the developing aleurone and embryo. Also found in the roots and shoots of the growing seedling
+Expressed in fruiting bodies
+Expressed at an early stage of floral initiation
+Expressed in newly fertilized embryos, but is rapidly degraded after initiation of the first mitotic division (PubMed:12296824, PubMed:12781695, PubMed:16611242). Weak, if any, expression during larval stages (PubMed:11702779)
+In leaves, mostly expressed in young tissues (PubMed:25249475). In fruits, highly expressed in green grains but fades out as they are yellowing to disappear in red mature grains (PubMed:25249475, PubMed:25190796)
+Highly expressed during embryogenesis and early postnatal life, but is expressed at lower levels in adults
+The SHN2 gene shows a pattern of expression associated with anther and silique dehiscence. Expressed in the stomium region when tapetum degeneration is initiated in the anther. Up to anthesis and until stamens fell off the senescing flower, restricted to the anther dehiscence zone. Subsequently, when petals and sepals withered, found at the bottom of each valve. During silique development, strongly expressed along the valve margin-replum boundary
+In the embryo at day 14.5 post-coitum, expressed in the basal, medial and lateral ganglionic eminences of the cerebral cortex, but not in the caudal ganglionic eminence (PubMed:23912123). Expressed in the corpus callosum from postnatal day 7 (PD7) to PD56 with a peak at PD14 (PubMed:24481677)
+Expressed in head neurons and body wall muscles during embryogenesis (PubMed:15035988). Expressed in head and body wall muscles and in punctate structures near the ventral nerve cord during larval stages L1 and L2 (PubMed:15035988). Expressed in primary vulval epithelial cells from larval stage L3, with expression increasing upon entry into L4 and diminished within six hours of adulthood (PubMed:15035988, PubMed:18675916)
+At 15.5 dpc, expressed in developing ribs and nucleus pulposus in intervertebral disks. At 18.5 dpc, expression is detected in proliferating and prehypertrophic chondrocytes
+First expressed at embryonic stage 13 dpc. Levels then increase gradually to reach maximum levels at adulthood
+Expressed in developing seeds from 10 to 30 days after flowering (DAF)
+Expression peaks at the slug stage, and is enriched in the prespore region
+In the KS483 cell model for osteoblast differentiation, expression levels peaks during the mineralization phase (days 18-21 of differentiation)
+In 3 days embryos
+Expressed at all stages of testicular development with highest levels found in fetal gonad
+Expression is constant from 12.5 dpc to 18.5 dpc in the cortex
+Widely expressed during embryogenesis (PubMed:11435699). Expressed in newborn mice with increasing expression from 4 to 24 weeks of age (PubMed:26260791)
+Ubiquitously expressed throughout development (PubMed:31584932). Highly expressed in early embryos (PubMed:31584932)
+Expressed both maternally and zygotically. First expressed at a high level in 0-2 hours embryos. Expression then gradually increases through the end of embryogenesis and laval development. Detected at lower levels in third-instar larvae and pupal stages. Expressed at a high level in adult females and at a lower level in adult males
+Accumulates essentially in meristematic active tissues. In seedlings, expressed in primary roots, shoot apical meristems (SAMs), cotyledons, and vascular tissues. Later observed in lateral root primordia, root tips, SAMs and young leaves
+First expressed in the early primitive streak. By stage 4, in Hensen node, early prechordal plate and notochord. Also expressed in early development in the neural plate ectoderm immediately anterior to Hensen node. Expression not detected after stage 10-12
+Detected in the eyeball at 18.5 dpc. Expression increases in the retina after birth from P4 to P90
+Expressed in three pairs of neurons, the pharyngeal pace-maker neurons MC, the amphid neurons ADF and the phasmid neurons PHA, from 3-fold embryos until the adult stage (PubMed:23315936). Expression in ADFL/R was very low through the normal life cycle but increased greatly in the dauer larval stage (PubMed:23315936)
+Expressed in dorsal root ganglia at 17 dpc onwards
+Present in fully grown and progesterone-matured oocytes. The level change very little even after zygotic gene transcription begins following the midblastula transition. Do not increase in abundance in the gastrula, neurula, tailbud, or tadpole embryo
+Present in hypodermal cells of the anterior cuticle 4 hours before each molt and is shed in the cuticle after ecdysis
+Expressed in developing siliques 13 to 15 days after pollination (DAP)
+Differentially expressed in the vascular lineage during embryonic stem (ES) cell differentiation, with expression increasing when the cells differentiate. At 7.5 dpc, no remarkable expression is detected. At 9.5 dpc, expressed in intersomitic vessels, dorsal aorta, forelimb buds, allantois/umbilical vessels, vitelline vessels, septum transversum, proepicardium, capillary plexi of the head and branchial arches, endocardium, yolk sac vasculature and placenta. At 10.5 dpc, expressed in forelimb and hind limb buds, intersomitic vessels, peripheral liver cells and umbilical vessels, with expression in the capillary plexi of the head and branchial arches no longer detected. At 11.5 dpc, high expression levels are limited to forelimbs and hind limbs and the most caudal intersomitic vessels
+Expressed in embryos and third instar larvae (at protein level) (PubMed:3919018, PubMed:2517292, PubMed:7641726). Levels are highest during embryogenesis, decrease through larval stages, and finally increase during pupation and adult stages (PubMed:7641726)
+Detected in germ cells in quiescent oocytes isolated from newborn P0 ovaries that have not yet commenced the growth phase. Protein levels increase after oocytes initiate growth, and follicular development reach the primary follicle stage at P6. Thereafter, protein levels remain at the similar levels (at protein level)
+In the basal portion of the P3 leaf primordium, expressed continuously within the stomatal row. At later stages, expressed in guard mother cell (GMC)-forming cells and in subsidiary mother cell (SMC) just before asymmetric division
+Expressed in the oral mucosa, including the palate, dorsal tongue, ventral tongue, and the floor of the mouth at 17.5 dpc (PubMed:32758484). Expressed in basal cells and differentiated keratinocytes at the ventral surface and the oral interpapillary cell column on the dorsal surface of the tongue at birth (PubMed:32758484). Ubiquitously expressed in basal cells and differentiated keratinocytes on the ventral tongue epithelium, however expression was limited to the cells in the interpapillary region and keratinized layer on the dorsal tongue at postnatal day 20 (P20) (PubMed:32758484). Also expressed in the buccal mucosa and esophagus at P20 (PubMed:32758484)
+During female gametogenesis, expressed in the female gametophyte at stage FG4 (four-nucleate stage) in all four nuclei. Expressed in the central cell in unfused polar nuclei at stage FG5 and secondary nucleus at stage FG6. Expressed in the egg cell nucleus during stages FG5 and FG6. Expressed very weakly in mature female gametophytes (stage FG7)
+At 9.5 dpc expressed in the myocardium and forming anterior foregut epithelium. By 12.5 dpc, expression is observed in the airways of the developing lung as well as in the myocardium. At 14.5 dpc, when proximal-distal differentiation in the lung is proceeding rapidly, expression is observed at high levels in the distal but not proximal airways of the developing lung. By 16.5 dpc, expression decreases in airway epithelium in the lung and expression is also observed in the vascular smooth muscle of pulmonary arteries (at protein level)
+The level of the 12-kDa form increases toward the late stationary phase of growth
+Levels increase in the fetal gut epithelium between day 15 and day 20 of gestation and during the first week after birth
+In Y strain, expression is seen in metacyclic trypomastigote form and in stationary, but not logarithmic-phase epimastigote forms. In Colombiana strain, expression is seen in metacyclic trypomastigote form only
+Expression in brown adipose tissue decreased greatly after birth
+Induced by seed imbibition with a peak at day 2 and then declines steadily until day 7. Not detected in developing seeds. Constitutive expression in root axis
+Expressed in seedlings, young leaves, root tips and lateral primordia (PubMed:22509260). In reproductive organs, present in the inflorescence, especially in pollen grains, nucellar cells and embryo sacs (PubMed:22509260)
+In globular embryos, expressed in the peripheral cells in a basal region above the hypophysis. In heart-stage embryos, expressed in the periphery of the presumptive hypocotyl and on the abaxial side of cotyledon primordia. During vegetative growth, expressed the abaxial side of very young leaf primordia. Expressed on the abaxial side of carpel primordia and then in a localized region on the abaxial margin that gives rise to the septum. Later, expressed in the tissue that gives rise to ovules
+Expressed in the mother cell compartment from T4 of sporulation
+Protein level is high around the time of septum formation, but a basal protein level is present throughout the whole cell cycle
+Expressed first in the inflorescence apex, then in young floral primordia, and in the petal and stamen primordia (PubMed:15728668). Localized to the tapetum and middle layers (PubMed:20805327)
+First detectable during gastrulation
+At 16 dpc, widely expressed with very low levels in heart, liver and neural tissues
+Maternally expressed transcript, detected in the animal pole at 4 hpf. At 5.5 hpf, widely expressed at 50% epiboly. At 24 hpf, widely expressed, with high levels in the otic vesicle. At 36 hpf, weak expression in the tail
+Highest expression during the active growth period 10-12 hours after germination
+Expressed in embryo, larvae and adults (at protein level)
+In 10.5 dpc embryos, widely expressed in mesenchymal tissues and is relatively abundant in the marginal zone of the neural tube and large blood vessels such as the aorta
+Is highly expressed during the young trophozoite stage but gradually decreases in amount with further growth. No protein can be detected during the ring stage, only small amount is expressed during the schizont stage
+Expressed from the tight mound stage. Also expressed in prespore and prestalk cells
+Expressed both maternally and zygotically. Maternal transcripts are widely expressed until the early gastrula stage, then become localized to the yolk syncytial layer. During somatogenesis and later stages of development, expression occurs mainly in neuronal and vascular tissues
+Expressed throughout development with highest levels in early embryo and pupae and lowest levels in late pupae and adults
+In developing anthers, expressed in tapetum during meiosis
+Expressed in the ventral part of the optic vesicles at 7 week dpc
+Expressed at high levels in growing cells, but at decreased levels in developing cells. Expressed in both prestalk and prespore cells
+Expressed during the parasite blood stage, specifically in schizonts and merozoites (at protein level)
+Expressed at day 11 until day 15, before dropping around day 17 before birth. Expressed in the cerebrum in embryos, but it declines after birth, while expression in the cerebellum starts to increase postnatally and continues thereafter
+Levels of isoform 1 decrease slightly during gastrulation but show a marked increase during neurulation and throughout embryogenesis. Expression of isoform 2 is low during early embryogenesis but increases after tailbud stages
+Highly expressed in embryonic cerebral cortex, hippocampus and cerebellum between day 18 and up to birth. Levels are distictly lower 10 days after birth, and not detectable in adults (at protein level)
+Highly expressed in early development (6 hours to 24 hours post fertilization), with lower expression thereafter
+Expressed in the floral meristem at very early stage of the spikelet (rice flower) development. Expressed in lemmas, paleas and lodicules from early to late stage of flower development
+Expressed both maternally and zygotically. Expressed throughout development, with highest expression observed in embryos (at protein level)
+During anther development, expressed from stage 4 to stage 6 in microsporocytes and tapetal cells. At the tetrad stage, expressed predominantly in tapetal cells. During microgametogenesis, expression decreases radically in the tapetum and microspores
+In the developing brain, expressed at low levels from 10 dpc stages to young adulthood (P25) with peak levels from 14 dpc to P8. In the cortex, expression first observed at 14 dpc uniformly in all cells. Also expressed in the innermost layers of the developing retina. Levels of expression remain unchanged from P8 until adulthood. In the peripheral nervous system, high levels found in virtually all neurons of the dorsal root ganglion
+First transcribed in the neurula at stage 15 and is maintained throughout later stages, reaching a peak around stage 42
+Expressed from stage 2, indicating it is expressed maternally. Expression is persistent through stage 40
+In the mature embryo, prominently expressed in the shoot apical meristem (SAM) (PubMed:27541283). In young seedlings, present in hypocotyls and mature part of roots, but not in root tips (PubMed:27541283). Later, also observed in the vasculature of cotyledons, in trichomes of emerging true leaves, and in joint part of the root to shoot (PubMed:27541283). In leaves, accumulates in guard cells and trichomes (PubMed:27541283). In flowers, mainly confined to the stigma of pistils and to the vasculature in the filament of stamens (PubMed:27541283)
+In young seedlings, expressed in the vascular tissues of cotyledons, leaf primordia, and shoot apical meristem (SAM). In roots, confined to a limited number of epidermal cells in proximity to the root apical meristem. In flowers, present in carpels and ovules. In developing ovules, observed in the funiculus and integuments
+Highly expressed in adult testis and low expression in the ovary. Highly up-regulated in testes of day 19 embryos, but not in later neonatal stages, nor any ovarian tissue from this period
+Two transcripts are detected of sizes 1.9 and 2.2 kb. Both are detected soon after fertilization and show relatively constant expression during the first 2/3 of embryogenesis. In 0-3 hours embryos, the smaller transcript is predominant and the levels of the two transcripts are somewhat reduced at the later stages of development, but they are found in approximately constant amounts during larval, pupal and adult stages. The smaller transcript is suspected to be a maternal transcript
+Expressed very early in development. Expression levels drop until shield stage and increase again during gastrulation and later development. Expressed abundantly in the developing brain, and at lower levels throughout the embryo
+Accumulates at the boundaries between the apical meristems and lateral organs in embryos, seedlings, and mature plants, and at the root apical meristem and in distinct cell files surrounding this area. First observed in the shoot apex of early-heart embryos. Within the apex of the late-heart stage embryo, the signal is detected in the peripheral region but not in the central region. At the bent-cotyledon stage, accumulates in boundary cells located between the shoot apical meristem (SAM) and the cotyledon primordia. In seedlings, weakly expressed in the basal cells of the leaf primordia. During the reproductive phase, present in boundary cells between the SAM and the flower primordia, and in boundary cells between the floral meristem and sepal primordia. In developing flowers, confined to regions that surround the floral organs at the base
+In tissues from a six months embryo, highly expressed in heart, testis and skeletal muscle, lower expression levels in kidney, intestines and prostate
+Expressed both maternally and zygotically. Expressed in the dorsal midline during gastrulation and neurulation
+Expressed both maternally and zygotically. Maternal expression decreases until the late blastula/early gastrula stage when zygotic expression begins. Expressed at an almost constant level through the subsequent developmental stages
+Strongly expressed in testis from 3 weeks onwards
+Preferentially expressed in normal human mammary epithelial cells as opposed to tumor-derived ones. The level of S100L was shown to correlate inversely with tumor progression
+At 8.5 dpc, expressed in the foregut. At 9.5 dpc, expressed in the ventral mesencephalon and rhombencephalon. At 12.5 dpc, expressed in ventral midbrain, myotome and kidney
+Expressed in the dorsal mesoderm of gastrulating embryos. Expressed in the midline and in a punctate pattern in the ciliates epidermis of stage 18 embryos. Expressed in otic vesicle, nephrostome and ventral neural tube of stage 34 embryos
+In flowers, expressed in the vasculature of sepals, petals, stamen filaments, and the gynoecium stylar region. In siliques, observed in the stigmatic region and epidermal layers
+Not expressed during embryonic development and first instar larvae. Expression detected from second instar larval stage into adulthood (at protein level)
+Expressed in both symmetric and asymmetric neuronal lineages (PubMed:21698137). In the posterior embryo, expressed in PVQ/HSN/PHB neuroblasts and their descendants (PubMed:14627726, PubMed:21698137). Expressed in the sensory ASE neuron lineage (PubMed:21698137)
+Not required for development
+Expression is detected at days 17-19, coinciding with the beginning of implantation, and continues throughout gestation
+Expressed in late stage embryos and throughout life. At L1, expressed in neurons, intestinal cells and hypodermal cells. In adults, expressed in the somatic gonad
+Expressed in the epithelial layer of the embryo in germinating seed (PubMed:14688295). Expressed in anthers of developing flowers during meiosis, tapetal cell death stage, young microspore stage and vacuolated pollen stage (PubMed:19454733)
+Not detected at early embryonic stages but is abundantly expressed in later stages with a peak at 17.5 dpc-18.5 dpc
+Expressed widely during early embryogenesis (PubMed:21698137). Expression is significantly reduced throughout the embryo after formation of the ASE neurons (PubMed:21698137). Expressed in the maternal germline (PubMed:21698137)
+In corollas, accumulates progressively during flower development, from buds to anthesis
+Expressed at 9.5 dpc in the growing edge of the limb buds and in the developing heart. At 10.5 dpc, strongly expressed at the edge of the limb buds, while expression in the heart maintained. At 11.5 dpc, detected in the apical ectodermal ridge of all 4 limbs, with higher expression in hindlimbs than in forelimbs. By 12.5 and 13.5 dpc, expression pattern more diffused in the limbs. At 13.5 dpc, clearly observed in the developing digits
+Expressed in the optic primordia and in cone photoreceptors of the differentiated neural retina
+During embryogenesis, expressed in the myotomal compartment of the somites and the anlagen of skeletal muscle. During fetal and adult stages, strongly expressed in all skeletal muscles. Not detectable in cardiac or smooth muscles
+Expressed at low levels at the onset of sporulation, it rises during sporulation (at protein level)
+Expressed first at gastrulation (stage 11) and is found to rapidly increase during neurulation and further development. In the adult, it is a major polypeptide in the esophageal mucosa
+Present at low levels in the amoeboid and early developing cells and reaches up to 20-fold higher levels during later stages of development of the fruiting bodies
+Strongly expressed in tapetal cells at the flower developmental stage 10 to middle 12, where the components of pollen coat are synthesized actively
+Expressed in fetal liver (at protein level) (PubMed:10605026). Expressed in placenta villous mesenchyme, cytotrophoblast, syncytiotrophoblast and invasive extravillous trophoblast (at protein level) (PubMed:28185362)
+In the 1.5-fold embryo, expressed in gut cells but not in epidermal cells (at protein level) (PubMed:15866168). In the 3-fold embryo, expressed in dorsal and ventral epidermal cells, but not in seam cells, and in the excretory cell (at protein level) (PubMed:15866168)
+Early expression seen in the anterior midline endoderm and prechordal plate precursor, subsequently activated in the overlying ectoderm of the cephalic neural plate. Later disappears in the mesendoderm while remaining in the prospective prosencephalic region of the neural plate ectoderm, ultimately expression is restricted to Rathke pouch, the primordium of the pituitary. Expressed in embryonic stem cells
+Strongly expressed in late-senescing leaves
+Detected within the Kolliker's organ, the outer sulcus, Reissner's membrane and the spiral ligament in the fetal inner ear at gestational weeks 12-14. Transient expression is observed in the stria vascularis at gestational week 14. At gestational week 15, it is also expressed in the vestibular system, particularly the saccular macula and ampulla, the periotic mesenchyme, the neuronal cell bodies of the Scarpa's ganglion and the epithelial cells of the semicircular canals
+Expressed from embryonic to the adult stages in testis. Expressed in embryonic stem (ES) cells
+Widely expressed during development, with strong expression in tissues with high levels of cilia-dependent developmental signaling such as the limbs, eyes, somite derivatives and brain. Significant amounts are found in the testis of 16 day old mice, at a late stage of pachytene spermatocytes when meiosis occurs. The level increases thereafter
+Expression begins soon after the mid-blastula transition
+In the brain, highest levels of expression are found at 11.5 dpc with decreased expression thereafter
+Expressed in the retinal lens fiber cells from postnatal day 28 (P28) to P45 (PubMed:27559293). Expressed in retinal lens beaded filament structures from P37 onwards (PubMed:27559293)
+Highly expressed in immature flowers, but progressively decrease as flowers mature and senesce
+Expressed both maternally and zygotically. Abundantly expressed in 1-7 than in 7-20 hours old embryos. Expressed uniformly at the preblastoderm stage, prior to the onset of zygotic transcription. In ovaries, it is not expressed in ovarian stem cells, oogonia or early cysts and is first detectable at stage 8 in nurse cells. At stage 10, it is expressed in the anterior end of the oocyte, and is uniformly distributed later on. Expressed almost uniformly in embryos from precellular blastoderm stage to the germband extended stage. At the germband extended stage, it is enriched in the mesoderm. During germband retraction, it is strongly expressed in the anterior and posterior midgut. At the germband retracted stage, it becomes less abundant and is mainly localized to the ventral nerve cord and the brain. In third instar larvae, it is strongly and almost ubiquitously expressed in all imaginal disks. Also weakly expressed expression in salivary glands. Not expressed in larval brain and gut tissues
+Expressed in embryo at 10.5 dpc
+Expressed in gametes
+Expressed in the brain of 11.5 dpc embryos where it is found in the telencephalon, but not in the hindbrain. Not found in the heart. In the adult, found in brain and thymus
+At 24 hours post-fertilization, expression is restricted to the tip of the developing tail
+Active only transiently in etiolated seedlings at the beginning of illumination
+At 9.5-10.5 dpc, highly expressed in the developing eye, restricted to the outer layer of the retina. At midgestation development, expression gets restricted to the forming retinal pigment layer. At 18.5 dpc, expression remains high in the retinal pigment epithelium and is also observed at the forming iris
+Expression peaks in S-phase (at the RNA level)
+Weakly and ubiquitously expressed throughout early development, and highly expressed in the anterior mesencephalon adjacent to the forebrain-midbrain boundary
+Expressed both maternally and zygotically. During gastrulation, expressed in the embryonic midline and in the involuting mesendoderm of the germ ring. During somatogenesis, expressed in the somitic mesoderm. At the 16-somite stage, expression is highest in the tailbud region, the eye and the dorsal somites. At 24 hours-post-fertilization (hpf), expressed in the neural tube, tailbud, posterior somites and forming fin bud. At 48 hpf, expressed in the fin buds and brain
+Expressed maternally during oogenesis. Observed during mitotic cell cycle from interphase through to early anaphase
+During desiccation stage of seed development increasing activity seems to be associated with appearance of isoform I (PSTI I) which has a stronger affinity for trypsin
+In the early larval stage of development, expressed in Z1.pa and Z4.ap distal tip cells and their descendants (PubMed:20026024). Not expressed in early embryos (PubMed:20026024)
+In pupae and in adults
+Expressed ubiquitously throughout embryonic development (at protein level)
+Expression is strongly linked to extension growth
+Expressed both maternally and zygotically. At the tailbud stage, expressed weakly in the adaxial cells and the future brain. From the 3-somite stage, strong expression in the adaxial cells and weak expression in the somites and tailbud. During somitogenesis, expression in the brain is gradually restricted to and up-regulated in the tectum and rhombomere boundary cells
+Accumulates during ovule development. Detected at low levels in ovules and in the embryo sac of stage 13 flowers (PubMed:22915737). Not detected during embryo development. In seedlings and young plants, present in some spots (presumably stomata) in cotyledons and later in veins of hypocotyls as well as of petioles, hydathodes, stipules, in roots and lateral root primordia, and in the lower halves of first leaves. Detected in the phloem, as well as in the cortex of inflorescence stems. In roots, confined in developing xylem cells in the part of the differentiation zone with well-developed root hairs (PubMed:26391711). Present in lateral root tips and subsequently in a larger area. Accumulates in columella cells of lateral roots (PubMed:26578169). Expressed at the base of developing flowers, including ovaries. In flowers, detected in parts of the major stem axis, and in the anther at some stages of development, present in veins of sepals and accumulates progressively in ovaries, filaments, receptacles, and ovules. Also detected in the valve margins and receptacles of siliques and at the joint between the stigma and the style, as well as in the tapetum around pollen grains in maturing anthers (PubMed:26391711)
+Specifically expressed at growth arrest
+It is detectable at low levels throughout the shoot apex and at enhanced levels in the inflorescence meristem, young floral buds and throughout the early stages of flower development and organogenesis. During floral organ differentiation it becomes spatially restricted to specific organ, tissue and cell types within the flower
+Down-regulated in embryonic stem cells upon differentiation into embroid bodies (at protein level) (PubMed:20154270, PubMed:21898682, PubMed:28494942). An analogous down-regulation is observed during differentiation of induced pluripotent stem cells (PubMed:21898682)
+Expressed both maternally and zygotically. Expressed in the unfertilized egg, with expression increasing from embryonic stage 12 up to the tadpole stage
+Encystment-specific
+Very high levels in the liver during the period of embryonic hepatic hemopoiesis
+Isoform 1 is widely expressed at 14.5 dpc embryos with highest levels in some areas of the developing brain, the lower gastrointestinal tract, as well as certain blood vessels. Primary cultures of endothelial cells lose high level expression of smooth muscle isoform with increasing number of passages. Telokin is expressed in the embryonic gut from 11.5 dpc with highest level at 15.5 dpc. Also expressed in developing bronchi from 13.5 dpc. High levels in 15.5 dpc bladder, ureter, urethra and rectum. Telokin expression is induced in reproductive tract during postnatal development
+Most abundant just before terminal desiccation of the embryo
+Expressed in fetal life in CD34+ progenitors present in the liver at 18 weeks of gestation but is absent in CD34+ precursors from fetal bone marrow at any developmental stage up to 22 weeks
+During fetal development, expressed at low levels in the colonic epithelium from 13 weeks of gestation
+Expressed exclusively in the posterior mesoderm and ectoderm of early Xenopus embryos
+Levels increase in embryos from globular stage onward during seed maturation. In seedlings, levels in cotyledons and hypocotyls decrease progressively to disappear 3 days after germination, except after glucose treatment that makes levels constant
+Expressed at all stages after 7 dpc. Expressed in brain structures including cortex, diencephalon, medulla oblongata, spine and cerebellum at 12 dpc. Expression in embryonic nervous system increases during development, as measured at 15 dpc and 18 dpc timepoints
+Expressed in all 3 larval instars but not adults or eggs
+Expressed in pupae and in adults, with a higher expression in males than females
+Expressed during the development of the floral organ primordia. No longer detected after the carpel has formed
+Detected in embryos just before the bud stage, in an oval patch in the polster (anterior prechordal plate) (PubMed:9108332). At the 3-somite stage, found in a horseshoe-shaped cluster of cells surrounding the head primordium (PubMed:9108332). From 24 hours post-fertilization (hpf) onwards, expressed in a belt-like shape on the anterior surface of the yolk sac (PubMed:9108332, PubMed:19021768). Little or no expression detected after hatching (PubMed:9108332, PubMed:19021768)
+Expressed primarily at the aggregation stage
+Expression is ubiquitous from the one-cell stage to 12 hours post-fertilization (hpf), restricted to the retina at 18, 24, and 30 hpf (PubMed:35457018). Expression encompasses the heart and midbrain region at 30 and 48 hpf. From 72 hpf to 5 dpf, the expression is restricted to the liver and gut (PubMed:35457018)
+In flowers, confined to ovules and vascular tissue of anther filament. In developing and mature seeds, expressed in embryo and the outer layers of the endosperm
+Expressed both maternally and zygotically. Maternal expression decreases during early cleavage stages becoming absent during gastrulation (PubMed:15567714). Zygotic expression begins during neurulation and expression levels decrease rapidly through the early tadpole stages before becoming enhanced again up till stage 39 (PubMed:15567714)
+Expression is detected in nurse cells during oogenesis throughout stage 10A and persists through stage 14 with some expression in the anterior part of the oocyte. Expression is ubiquitously detected at all stages of embryogenesis. Observed in salivary gland cells from heat shocked transgenic third instar larvae
+Expressed in embryos at about the 50 cell stage (PubMed:16905130). Expressed in most, but not all cells of larvae and adults, especially in neuronal and hypodermal cells (PubMed:16905130)
+Already detected in embryonic stages, peaks at postnatal day 7, and decreases thereafter to adult levels
+Very low levels in whole embryos, high levels in adult tissues
+First observed in pollen right before the opening of floral buds. Levels increase during pollen maturation
+Detected at 7.5 and 8.0 dpc in the allantois and blood islands of the yolk sac, and in cells fated to become the endocardium. At 8.5 dpc, detected in the allantois and the nascent vasculature of the yolk sac, the paired dorsal aortae and heart (PubMed:10742113). At 9.5 to 11.0 dpc, detected in endothelial cells of the paired dorsal aortae, in intersomitic vessels and in a network of smaller vessels in head and trunc mesenchyme, and in endothelial cells lining the dorsolateral sector of the cardinal vein (PubMed:10742113, PubMed:18931657). At 10.5 dpc, detected inprecursors of the lymphatic vasculature (PubMed:18931657). At 12.5 dpc, detected in branching vessels and in nascent vibrissae follicles. Detected in vibrissae follicles and pelage follicles at 14.0 dpc (PubMed:10742113). Detected in primary lymph sacs at 13.5 dpc, but is not detected in embryonic or adult lymph vessels (PubMed:18931657)
+In the medial basal hypothalamus, levels are low at birth and increase during neonatal and infantile development to reach a maximum during the mid-to-late juvenile period at postnatal days 24-30
+At 17.5 dpc, expressed in brain including hippocampus and corpus callosum (PubMed:28521134). Isoform 1: Expression begins after birth at P1-P5 stages and is maintained in adults (PubMed:9660871, PubMed:28521134). Expressed in mature neurons (PubMed:28521134). Isoform 2: Expressed at 13 dpc, 16 dpc and 18 dpc stages (PubMed:9660871, PubMed:28521134). Expression is increased at P1-P5 stages and persists at low levels in the adult brain (PubMed:9660871, PubMed:28521134). Expressed in unpolarized hippocampal neurons and throughout neuronal development (PubMed:28521134)
+Expressed during vegetative growth phase
+Expressed from the 1-4 cell stage and in DFCs at 75%-epiboly stage. By the 6-somite stage, its expression in the Kupffer's vesicle is detectable in addition to some basal expression levels in other cells. Later at the 18-somite stage, detected ubiquitously throughout the embryo. After 2 dpf (days post fertilization), expressed in endodermal organs, including the pancreas and liver
+Expressed from embryogenesis onwards with high expression during the larval stages of development, peaking at the L3 stage and decreasing at the L4 stage of larval development. Ubiquitously expressed, but expression in seam cells begins in embryonic precursors soon after fertilization and is most prominent in larval stages of development. Expression is also prominent in the germ line during the L1 stage of larval development. Also expressed in pharyngeal gland cells, VC4 and VC5 neurons, and in the hermaphrodite uterine vulval uv1 cells
+Expressed through the elongation stage of the spermatids but absent from mature spermatozoa
+Expression is elevated during lactation
+Expressed in larvae, nymphs and at lower level in adults
+Expressed maternally. Expressed in eggs but not oocytes (at protein level). The RNA is subject to translational control and is only adenylated in eggs. Expression stops soon after fertilization, when the mRNA is deadenylated. Not expressed in adults
+Expressed at early stages of melanosome differentiation
+Down-regulated in the retina at smoltification, the metamorphic transformation from a parr to a molt
+Maternally expressed. Expressed at the animal half during the blastula stage. Expressed in the central, posterior and anterior neural plate regions, including the eye field at stage 12.5. Expressed in the posterior neural plate at stage 15. Later on, expressed in the developing nervous system. Expressed through the eye vesicle at stage 20. Strongly expressed in differentiating primary neurons in the brain, spinal cord and retina from stages 24 to 31. Not detected in the lens at any developmental stages
+Expressed maternally and zygotically. Expressed throughout development with a peak of expression during early embryogenesis (0-9 hours old embryos). Weak expression in larvae, pupae and adult flies
+Expressed at a low level during embryogenesis. Expression increases sharply approximately four hours before hatching with levels peaking during the first larval stage. Levels then decrease as development progresses to adulthood
+Detected by embryonic day 25, by which time the optic cup has formed and the ganglion cell layer can be distinguished. A rapid increase to levels 3- to 4-fold greater than those seen in adult retina occurs in the period from birth (P0) to postnatal day 6 (P6). During this interval, the horizontal, bipolar, amacrine, and cone cells arise from the neuroretinal layer, the inner nuclear layer, and outer nuclear layer separate, and the outer plexiform layer begins to form. Levels begin to decrease by P8, when the rod outer segments are Still differentiating, and reaches its lowest levels in adult retina
+Expressed during adult stages
+Developmental regulation only occurs in liver, heart, kidney and spleen
+Present in all developmental stages but most abundant in L1-L3 larvae
+Expressed in areas of the first and second branchial arches, before any apparent cellular or morphologic differentiation. Later in development, all expressing tissue in this region, including the mesenchyme underlying the olfactory epithelium, the primary and secondary palate, the molar tooth papillae, and the stroma of the submandibular gland, appear to be derived from ectomesenchyme of neural crest origin. By day 16.5, all areas except the developing molars are BARX1-negative. In addition, BARX1 marks the area of the future stomach in the primitive gut at embryonic day 9.5, and is present in the mesenchymal wall of the stomach until embryonic day 16.5
+Hypoderm isoform has high expression levels in hypoderm during late embryogenesis, late larval development, pupariation and adult eclosion. CNS isoform has constant expression level in CNS throughout the life cycle
+Moslty expressed in leaves where ent-kaurane diterpenoids accumulates but weakly expressed in germinating seeds in which gibberellins are produced
+First expressed in embryo at 9 dpc. Expressed in the dorsal midline of the forebrain at 10.5 dpc at the boundary between the diencephalon and telencephalon, the septum, and the lamina terminalis. Expressed in the choroid plexus of the third ventricle, the dorsal part of the spinal neural tube, the dorsal sclerotome and the dorsomedial lip of the dermomyotome between 10.5 and 12.5 dpc. Expressed in the midline of the forebrain and in the dorsal spinal neural tube at 12.5 dpc
+Levels increase as metamorphosis progresses, reach maxima in juveniles and decrease as adulthood approaches
+Down-regulated in the shoot apical meristem (SAM) upon floral induction
+Widely expressed during embryonic development
+Expressed following fertilization and during embryogenesis in four neuronal cells (PubMed:23671427). Expressed in BAG, URX, AQR and PQR sensory neurons and cells in the head and tail in L1 larval stage and in the body wall muscle and vulval cells later in larval development (PubMed:23671427, PubMed:23946438). Expressed in cells of the pi uterine cell lineage from late L3 to mid L4 (PubMed:9834196)
+Occurs in similar relative abundances in infected hepatopancreas, schistosomula and adults
+First expressed at 7 dpc. At 8.5-9 dpc expressed in all developing organs. Later on during embryogenesis shows a more restricted expression pattern. At 9.5-12.5 dpc it is strongly expressed in the developing brain, optic vesicle and the otic placode
+Expressed in specific regions in the limb buds of stage 13 embryos
+First observed in a dorsal domain of floral meristems, prior to any morphological dorsoventral asymmetry. Later expressed in dorsal organ primordia
+At 18.5 dpc highly expressed in the epidermis, and weakly in the stomach
+Highly expressed in the early placenta. Expression of epil peptides in the villous cytotrophoblast is different from that displayed by the syncytiotrophoblast. In fetal tissues it was identified in the perichondrium of all four limbs, vertebrae, and ribs. It was abundant in interbone ligaments
+Ubiquitously expressed in embryos. In early larvae, expressed in hypodermal cells, seam cells and body wall muscle cells
+Preecdysial adult cuticle deposition
+Detected in late pupal stages and in adult (at protein level)
+Detected from 8h up to the adult stage at relatively constant levels (at protein level) (PubMed:9703021). From 16 hours embryo, detected in cells of the brain, the ventral nerve cord, and the midgut (PubMed:9703021)
+Expressed in the embryonic central nervous system (at protein level) (PubMed:32955431). First detected in stage 14 embryos in cells of the future proventriculus (PubMed:8901578). From stage 15 onwards, strongly expressed in the proventriculus as well as in endodermal cells of the anterior and posterior midgut, whereas the remainder of the midgut shows only very weak expression (PubMed:8901578). No expression is observed in the cells of the developing gastric caeca (PubMed:8901578). Expression in the ventral cord and the brain is nonsegmental (PubMed:8901578)
+In EML and MPRO cell lines, low levels in undifferentiated cells. Induced during maturation to promyelocyte stage of neutrophil differentiation. Decreased during neutrophil terminal differentiation
+First detected at stage 13. Increases gradually and peaks at stage 57-61 then decreases to the level seen in adult
+Activity detectable in embryos by day 14. Increases until 7 days post-hatching, then decreases again
+Throughout development the long isoform is more abundant. In embryos, ubiquitously expressed with high levels detected in cranial neural folds, subregions of pharyngeal arches 1 and 2, circumpharyngeal neural crest and limb buds
+During gastrula and neurula stages in involuting mesoderm and in the notochord
+First observed at tailbud stage in the developing Kupffer's vesicle, the zebrafish laterality organ. At the 10 somites stage, it is expressed in the otic vesicle and the floorplate. At 18 somites it is expressed in the pronephros. From 23 somites, it is no longer detected
+Ubiquitously expressed throughout the embryo from fertilization onward. Accumulates at higher levels in cells of the telencephalon, the ventral hindbrain and the gut
+Expressed in mid-late embryo, throughout larval development and in the adult (PubMed:11959845). Expressed in larvae in various motor neurons, including cholinergic DA, DB, VA, and VB, and also GABAergic DD and VD, but not AS or VC, nor in SAB or DA9 motor neurons (PubMed:28056346)
+Expressed in the germinating embryo. Also found in the roots and shoots of the growing seedling
+Predominantly expressed in the embryo and down-regulated during development
+Expression initiates prior to the ninth embryonic nuclear division cycle within 1.5 hours after fertilization. By the cellular blastoderm stage (the 14th nuclear division cycle) is localized into 14 stripes, 1-2 cells wide, spaced along the anterior-posterior axis of the embryo
+Not expressed in red stage fruit tissue
+In interphase cells, it is scattered throughout the nucleoplasm. In mitotic cells, it strongly associates with condensed chromosomes from the prophase to telophase
+Increased expression in S and early G2 phases and lower levels in late G2 and M phases
+Expressed in the developing urogenital system (developmental stages 20 to 23) and later in the gonads (stages 24 to 27) at both male- and female-producing temperatures, but up-regulated at the male-determining temperature. May be highly expressed in testicular differentiation and weakly expressed in ovarian differentiation
+Expressed at 7 dpc, down-regulated at 11 dpc, re-expressed at 15 dpc and peaks at 17 dpc. Present in embryonic diaphragm (at protein level)
+Present at all embryonic stages (at protein level)
+First detected at embryonic day 9 and in the brain, expression increases steadily from embryonic day 17 to postnatal day 19
+Highest expression at premolt stage and lower expression at postmolt and intermolt stages
+Expressed throughout development, high during embryonic and adult stages. Isoform T1 is predominantly expressed during embryo and adult stages
+First detected at low levels in the blastula stage and begins to accumulate in the margin of the blastoderm. At the shield stage, when gastrulation starts, expression is higher on the dorsal site. As gastrulation proceeds, expressed at high levels in the anterior ectoderm. In the 1 day old embryo, at the early pharyngula stage, expression in the developing brain is very strong and expression extends in to the spinal cord
+Abundant at 3 hours after induction of meiosis but undetectable before induction or at 4 hours and later
+At 15 dpc-17 dpc, mainly in the developing retina, telencephalon and myoblasts. At 12.5 dpc, detected in the developing trigeminal and dorsal root ganglia, and in the developing spinal cord (at protein level). Highly induced during primary fetal liver erythropoiesis. Expressed in the inner retina during late embryogenesis, in nucleus. Highest levels at 14.5 dpc for isoform 2 and P12.5 for isoform 1
+Specifically expressed in the mother cell during sporulation under the control of the sigma-E factor
+Expressed in adult, pupae and third instar larvae. Levels peak at the late embryonic and late larvae stages. Relatively low expression in the pupal stage, with a slight increase in the adult
+Expression levels increase dramatically during smooth muscle maturation
+Expressed in embryos and adult (at protein level)
+Expression increases during the late culmination stage
+Expressed from early third instar to late pupal stages
+Expressed in cerebral cortex, predominantly in the cortical plate and intermediate zone and weakly in the ventricular zone, in neurites and the growth cone of neurites of the hippocampus at 15 dpc (at protein level). Expressed in embryo at 7, 11, 15 and 17 dpc. Expressed in the preplate which consists of the Cajal-Retzius cells and the precursors of subplate neurons, in neurons of the telecephalon, in primordia of cerebral cortex and hippocampus at 12 dpc. Expressed in the cortical plate, striatum and fourth ventricle of the brain, in the cartilaginous tissues including Meckel, costal, vertebral and tracheal cartilage at 14.5 dpc. Expressed in cerebral cortex, hippocampus, olfactory bulbs, rostral migratory pathway and the striatum at 17 dpc
+Expressed in fifth instar larvae; highly expressed in fat body, followed by hemolymph and to a lesser extent in integument, head, and midgut
+During development, expression in the brain decreases gradually (PubMed:15556296). Shows increasing expression in testis from 16.5 dpc onwards, with maximum expression at postnatal day 21 (PubMed:31932482)
+Expressed in 24 hours imbibed seeds and during leaf senescence
+During embryonic development, most strongly expressed in neural tissue. Expressed in a dynamic pattern during neurulation: from 8.5 dpc to 9.5 dpc, the period of cranial neural closure and spatially regulated proliferation, it is expressed strongly in the ventral region of the cranial neural tube. By 10.5 dpc, expressed more uniformly along the dorsal and ventral aspects of the cranial neural tube. Also expressed in the neural retina and lens
+Expressed in embryos (at protein level) (PubMed:17498661, PubMed:26842564). Also expressed in L4 larvae and adults (PubMed:17498661). Expressed to a lesser extent between L1 and L3 larval stages (PubMed:17498661)
+Expressed first in 20 dpc fetal brain and decreases thereafter during development
+Expressed throughout the plant life cycle
+Expressed during seed development. Detected during seed maturation and decreased during germination
+In seedlings, first expressed in petioles and leaf blades of the cotyledons as well as tops and bottoms of the hypocotyls (PubMed:25490919). Later present in whole hypocotyls and weakly in the cotyledons and root tips (PubMed:25490919)
+First detected at 7 dpc. Strongly expressed in cranial mesenchyme and caudal mesoderm. Expression in cranial mesenchyme decreases starting from 10.5 dpc
+Is increased at middle to late mesenchyme blastula stage, level remains high through the 3-day pluteus stage
+Stably expressed throughout development
+Up-regulated more than 4 fold in the large cell variant (LCV) stage compared to the small cell variant (SCV) stage; at protein level. LCVs are thought to be more metabolically active than SCVs
+Up-regulated in the heart from 1 week after birth through adulthood
+Expressed in type II neuroblasts in larval brain (at protein level) (PubMed:27151950, PubMed:28245922). Expressed in a complex dynamic pattern in early embryos, including the midline and midline glial cells (PubMed:8223245, PubMed:1577186, PubMed:2834248). Expressed throughout development with lower levels during larval development (PubMed:1577186). Expressed in the eye imaginal disk in and posterior to the morphogenetic furrow (PubMed:8033205). Isoform P2: Detected in the precellular blastoderm stage localized at the anterior tip of the embryo (PubMed:8223245). Detected during gastrulation in the mesoderm (PubMed:8223245, PubMed:23757412). As the germband retracts (stage 12) detected in a few cells located at the dorsal roof at the midline of the CNS (PubMed:8223245). These cells correspond to the midline glial cells, in which expression continues until the end of embryogenesis (PubMed:8223245). Major isoform expressed in the eye imaginal disk in and posterior to the morphogenetic furrow (PubMed:8033205). Isoform P1: Expressed within the differentiated region of the disk including and posterior to the morphogenetic furrow in the proneural photoreceptor clusters (at protein level) (PubMed:23757412). Detected during the cellular blastoderm stage in two broad stripes in the lateral neurogenic region (PubMed:8223245). At the beginning of gastrulation detected in the dorsal edge of the neurogenic region (PubMed:8223245). During segmentation (stage 11), detected in the ventral ectoderm and in a group of cells surrounding the future tracheal pits, in the head region and the lateral body wall (PubMed:8223245). In the CNS, detected during germband retraction, in the glial cells and in the midline (PubMed:8223245). In larval brains, major neuroblast-specific isoform (PubMed:22143802)
+Expressed in embryo as early as the 11th week of gestation
+Expressed throughout much of the embryo at 7.5 dpc, in mesoderm and ectoderm-derived structures at 8.5 dpc, and throughout much of the embryo at 9.5 dpc but is absent in the extra-embryonic visceral endoderm (VE) at all stages
+First expressed in the cerebral cortex after the preplate stage (>E12). At embryonic stage 15.5 dpc and up to 17.5 dpc, it is expressed in cortical plate and in the marginal zone, whereas in adult brain, it is present in all cortical and subcortical regions of the brain. In the developing cerebellum, expressed in the intermediate zone at stage 17.5 dpc, in the molecular layer in newborn, and in the granular as well as molecular layer in adult. In the adult brain, expression in interneurons is also observed
+Detected at embryonic stage 18 dpc in kidney, heart, brain, lung, skeletal muscle and thymus. Expression is particularly strong in kidney
+Present in the margins and tips of the oldest leaves, senescent leaves, differentiating xylem and at the abscission zone of flowers. In flowers, expressed in developing anthers and seeds. Accumulates in stigma, mature anthers, sepals, and petals of older/fully opened flowers. Also present in floral organs after fertilization. In mature siliques, observed in abscission zones and in the distal portion of the valve margins
+Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule
+Expressed during development; especially from 12 hours of development
+Expression is increased during epithelial differentiation in intestinal mucosa as well as in kidney, liver and lung
+Highly expressed in the blastula stage with reduced expression through the rest of development
+Expressed both maternally and zygotically. Maternal expression is gradually replaced with zygotic expression between the morula (stage 5) and tadpole (stage 34) stages
+In the testis, expressed at low levels at 3 weeks with levels markedly elevated by 4 weeks and into adulthood (at protein level)
+A peak of expression has been observed between postnatal days 15 and 25, coinciding with the period of active myelination
+Expressed both maternally and zygotically. Expressed in oocytes, eggs, throughout early embryonic development, and in adults
+In kidney epithelial tissues, the shorter form predominates in young (1 day old) rats while the longer form becomes more prevalant during aging
+Expressed in mid-late pachytene spermatocytes at the stages VII, VIII and IX of the semiferous epithelial cycle
+First observed in all young embryo cells. At the globular stage, restricted to apical region. Later confined to the protoderm area leading to cotyledon primordia and the root apex. In mature embryos, mostly localized in the L1 layer of the SAM, apical regions of cotyledons and the root apex, and, to a lower extent, in protoderm of other regions. In seedlings, expressed in developing tissues of the shoot, including the SAM and epidermis of organs primordia, especially in L1 layer cells. In roots, localized in quiescent center (QC) central cells, columella initials and cells below the QC, the lateral root cap (LRC) and the initial cells destined to give rise to the root epidermal cell file and the LRC. Expressed in epidermal emerged from under the LRC, with levels vanishing in elongation zone. Specifically detected in the small daughter cells after the first asymmetric pericycle cell division during lateral roots emergence. Subsequently, the expression expands to the adjacent small daughter cells from the second asymmetric cell division, resulting in a central core-specific expression pattern
+Expressed in the nervous system at all larval stages. Expressed in somatic gonad and in the ventral nerve cord at L2 larval stage. Expressed in somatic gonad, in ventral uterine (VU/AC) cells and in the committed anchor cell at L3 larval stage. Expressed in vulF cells of the vulva, uterine cells and in uterine seam cells (utse) at L4 larval stage
+At 7.5 and 8.5 dpc, detected in extraembryonic membranes and cells that form the chorionic plate
+High levels in first trimester deciduas. Higher levels in the endometria during secretory phase than the proliferative phase, especially after the mid-secretory phase
+Terminally differentiated macrophages
+At zygotic stage; specifically expressed in the notochord. Maternal transcripts are detected at cleavage stages and reduced during gastrulation
+Elevated expression during the early S phase of the cell cycle, followed by a gradual decrease during late S phase
+In mid instar larvae salivary glands, levels are low during puff stage 1, increase during puff stages 2-4 and diminish from stage 5 onwards. In prepupae, isoform A is the predominant form during puff stage 19 and the transition to stage 20. By stage 3 it is present in the gut, Malpighian tubules and the fat body, levels persist beyond stage 11
+Isoform 6, isoform 7 and isoform 8 are detected in embryonic hippocampus but not in later developmental stages. Isoform 14, isoform 15 and isoform 16 are adult-specific
+Accumulates during mitosis at centromeres during prometaphase, but dissociates from the centromere at the meta- to anaphase transition
+Expressed at embryonic day (E) 12.5 in embryo
+Broadly expressed in late embryonic and early postnatal cerebellar neurons, including premigratory granule neurons of the external granule cell layer, but expression is largely down-regulated. Weak expression in Purkinje cells throughout development. Alpha- and beta-DG proteins are also present on the Bergmann glial scaffolds used by granule cells during early postnatal radial migration. In the peripheral nerve system, expression briefly precedes and parallels myelination. First expressed at 18.5 dpc in spinal roots, dorsal root ganglions and nerve trunks. At P1, at the onset of myelination, expressed in motor roots. At P5 and P15, expression progressively increases in sensory roots and peripheral nerves. Between postnatal 2 weeks and 18 months, localizes at the nodes of Ranvier as well as at the Schwann cell outer membrane
+Expressed during the asexual blood stage; expression is low at the ring stage and then increases through the trophozoite and schizont stages (at protein level)
+First expressed weakly at mid-gastrula (stage 11) but expression becomes prominent at stage 15
+Detected in adults and larvae
+Expression is first detected on postnatal day 21
+M.xanthus is a rod-shaped bacterium with a complex life cycle that includes formation of fruiting bodies. This protein is induced during the aggregation phase of fruiting body formation
+Accumulates during leaf expansion. First observed at the tip of the leaves 12 days after sowing (DAS). At 14 DAS, expressed throughout the leaf blade to fade out thereafter in a basipetal manner. In mature leaves, detected in vascular tissue, especially in companion cells (PubMed:24806884). Accumulates to higher levels in old rosette leaves than in young rosette and cauline leaves (PubMed:25920996)
+Expression begins around stage 10, primarily in the developing CNS. In stage 16 embryos, it is expressed at highest levels throughout the CNS, and weak expression is seen in portions of the peripheral nervous system, most clearly in the lateral sensory clusters
+Germination specific
+High expression in thymocytes. Neither expressed nor inducible in mature T-cells. Inducible in CD2 negative peripheral blood lymphocytes
+Found in fetal lung and small intestine, and at lower level in fetal skin and muscle
+Expressed during the late G1 phase and the major part of the S phase
+Accumulates in developing flowers and its level drops as flowers mature
+At embryonic day 8.5, it is highly expressed in the head mesenchyme, but neither in the somites nor in the presomitic mesoderm. By day 11.5 it is expressed fairly ubiquitously throughout the embryo
+In the embryo, highest expression occurs at day 7
+Highest expression in adults
+Expressed weakly in larval stage L1 and strongly throughout the remainder of larval development (PubMed:9764821). Expressed in larval posterior intestinal cells and neurons (PubMed:9764821, PubMed:27402359)
+First detected at 7.5 dpc (PubMed:16643851). Tends to be expressed weakly during the early stages of embryogenesis. Expression increases over time in different growing and differentiating tissues, including brain (11.5 dpc), vertebrae (14.5 dpc), primordia of vibrissae follicle (15.5 dpc), intestinal sub-endothelium (16.5 dpc), pancreas (16.5 dpc), eyeball (16.5 dpc), liver (16.5 dpc), telencephalon (18.5 dpc) (PubMed:16643851). In the developing neural tube at 8.5-9.0 dpc, preferentially expressed in cells with one or more neuronal extensions (PubMed:16643851). During spermatogenesis, weakly detected in primary spermatocytes, but expression increases, reaching strong levels in elongated spermatids (stage V) and mature sperm (at protein level) (PubMed:16643851)
+Expressed in the interneurons BDUL/R, AVG, AIML/R, RIS, AVD and PVT, the chemosensory neuron pairs PHA and PHB, the motor neurons RID and RIML/R, the sensory neurons AQR and PQR, and in the PVPL/R interneurons (PubMed:19686386). Also expressed in rectal gland cells rectD and rectVL/R, the intestino-rectal valve cells virL/R and three posterior arcade cells in the head (PubMed:19686386)
+Overexpressed in Wilms' tumor samples
+Expressed in the early developing retinal pigmented epithelium and in the peripheral retina
+Low levels detected in cochlea in neonatal pups at P1. Levels increased 2-fold by P5 and rose further to 16-fold at P13. Expression declined somewhat in adult mice. At 9.5 dpc, as during all stages of development, it is strongly expressed in the neural fold, the limbbuds and the heart
+Expressed in germinal vesicle oocytes, not in metaphase II oocytes. Expressed in embryo from 8.5 through 16.5 dpc (at protein level). Expressed in the zygote through to the blastocyst stage. Expressed in area lateral to the rhombencephalic floor plate at 12 dpc. Expressed in the anterior region of the brain, including the telencephalic olfactive nuclei and the hippocampus anlage at 17 dpc
+Expression is increased during late postembryonic development (PubMed:10550049). In embryos, there is diffuse nuclear expression at interphase, but this reduces by the metaphase-anaphase transition (PubMed:12827206). There is diffuse expression in pre-meiotic germline nuclei as the nuclei enter meiotic prophase and later in the diplotene and diakinesis phases of prophase (PubMed:12827206)
+Expressed in the germline throughout early pachynema in meiotic prophase I (at protein level) (PubMed:27011106, PubMed:34252074). Expression progressively increases during pachytene in meiotic prophase I, peaking during mid-pachytene and reducing at late pachytene (at protein level) (PubMed:27011106)
+Not detected in resting conidiospores. Transcription is activated during the isotropic growth phase of conidiospores
+Expressed maximally in the early stages and late stages of the parasite erythrocytic development
+In male germ cells just prior to or during the first, but not the second meiotic division
+Expressed during the late globular stage and late torpedo stage of the embryo, and in distinct cells of unfertilized and fertilized ovules
+First detected at day 25 postpartum, the expression increases until day 35 and remains identical till adulthood
+Expressed at all stages including the dauer stage. Expression in the ventral cord and near the vulva starts at the L4 larval stage
+More abundant in the procyclic forms than in the bloodstream forms
+Expressed in fetal tissue
+Up-regulated at 12.3 dpc in dorsal root ganglia (DRG) and in some sensory cranial ganglia. A slightly decreased expression could still be detected in sensory ganglia at 16.5 dpc. It is not known if expression in sensory neurons persists in adult life
+Primarily detected in 34 day-old embryos. Widely expressed at different levels during embryonic development where it is predominantly expressed in cerebellum, kidney, and cerebrum and to a lesser extent in lung, heart, skeletal muscle, tongue, and adrenal gland
+Expressed at low levels during the early stages of development, with levels increasing strongly around hatching period at 72 hours post-fertilization. Expression levels remain high in the adult stage
+Expressed throughout development and in adults (at protein level). Isoform A: Highly expressed in adults and low levels of expression in larvae and pupae (at protein level). Isoform B: High levels of expression in larvae (at protein level), and low levels of expression in embryos (4-24 hr after oviposition), pupae and adults (at protein level)
+At stage 14, detected in cells of the anterior and anterior-lateral rim of the neural plate. After neural tube closure, detected externally in cells in the dorsal-midline of the closed neural tube. At TS3 expressed in the region corresponding to olfactory placode, at TS5 detected in all branchial arches and at stage TS6 expressed in the putative apical ectodermal ridge of the limb buds
+Expressed only in sexually active fish
+Undetectable in nulliparous mammary glands but strongly expressed in 11.5 dpc pregnant mammary glands. Strong expression continued until the end of the lactacting stage and then rapidly diminished during the weaning stage
+Expressed in testis at least from P5 to P40. Expression increases with sample age. Detected in the flagella of elongated spermatids, but the expression levels reduce as the sperm matures (heads move towards the center lumen) (PubMed:23303679)
+Present in all embryonic blastomeres at early stages of development
+Expressed during late flower bud development
+This protein seems to be found in newborn B.jararaca venom but not in adult snake venom
+mRNA first detected in the tailbud embryo (stage 26) in the paired heart primordia and in the condensing epithelium that will form the pronephros; at the late tailbud stage (stage 34) in the developing retina and epiphysis. As development proceeds, detected through the entire length of the heart tube, in the muscular tissue of the outflow tract, and in the duct epithelium of the pronephros. During later development, mRNA found in all subregions of the heart, in the glomus, tubules and duct of the pronephros, in the retinal ganglion cell layer (gcl) and in the epiphysis
+Not detected in the embryo at 12.5 dpc. At 14.5 dpc, expressed in the developing inner ear. At 16.5 dpc, expressed in the utricle and saccule. At 18.5 dpc, expressed specifically in the region of the sensory cells of the cochlea, utricle, saccule and crista ampullaris
+Not expressed maternally. First detected at 9 hours post-fertilization (hpf), with high levels until 24 hpf. Also expressed in adult
+Expression is limited to late stages of embryogenesis. First detected at 48 hours of development and restricted to regions of ongoing chondrogenesis. Expression is observed in the ethmoid plate and the trabeculae cranii of the neurocranium as well as in some presumptive cartilage cells of the pharyngeal arches. Expression is furthermore observed in the forming cartilage of the pectoral fins. At 72 hours of development, accumulates in the ceratobranchial and basibranchial parts of the gill arches
+Expressed in developing embryo
+In yolk sac, first detected at low levels at 8.5 dpc, with significant expression detected at 10.5 dpc in myeloid precursor cells. In liver, expressed from 16.5 dpc to P7.5 with highest levels detected from 18.5 dpc to P0.5. In spleen, first detected at 16.5 dpc, with peak levels detected at 18.5 dpc and P0.5 and expression persisting through the spleen maturation to the adult stage. In bone marrow, high expression levels detected from 16.5 dpc until adulthood. In lung, first detected around the time of birth, with levels increasing significantly from P14.5 towards adulthood
+Expressed in developing seeds from 1 to 15 days after flowering (DAF)
+Expressed at high levels in Th1 cells on day 3, 5 and 7 after primary activation. Very low expression in Th2 cells on day 3 and not detectable on day 5 nor day 7 after activation
+Expressed in the mesoderm during gastrulation. Expressed in the notochord of neurula stage embryos
+Localized in the shoot apical meristem (SAM) dome, the emerging leaf and root primordia, the provascular strands of developing seedlings, and the epidermis and cortex of the meristematic and elongation zones of the primary root tip, and in the protoderm of heart- and torpedo- stage embryos
+Expressed in the presumptive lens ectoderm at stage 24. Expressed in the pronephros from stage 28 onwards. Expressed in the forming tubules but also in the glomus of the pronephros from stage 33. Expressed in cells of the optic vesicle in a dorso-temporal location and in cells showing the expected dorsal location of Rohon-Beard neurons in the neural tube at stage 35
+Increases at the onset of leaf senescence
+Expressed from late pachytene stage and expression persists during embryonic development
+At 10.5 dpc, expressed largely in the brain and neural tube
+Expressed both maternally and zygotically. Restricted to oogenesis and early embryogenesis. During oogenesis, levels increase between stage I and II and then remain constant through oocyte growth to stage VI. During early embryogenesis, levels remain approximately constant up to 5 days after fertilization. In older embryos levels decrease, being totally absent at 15 days post-fertilization (at protein level)
+At germband retraction (stage 12), expression is high in the embryo amnioserosa and relatively low at the apical edge of the leading edge/ dorsalmost epidermal (DME) cells (PubMed:18816840, PubMed:23579691). Whereas at dorsal closure (stage 13), expression is relatively low in the amnioserosa and high in the DME cells (PubMed:18816840, PubMed:23579691). Isoforms containing exon 7 are detected in all stages of development and are expressed in embryos, early and late larvae, and adults (PubMed:8568878)
+Expressed during reproductive growth and strongly expressed during seed germination. Expression is not detected until 3 days after germination, and subsequently becomes stronger. Not present in root of seedlings growing at different stages
+Expressed in molar and incisor tooth germs at 14.5 dpc
+Ubiquitously expressed in early embryonic stages with enrichment in the neuroectoderm at later stages
+Expressed during all phases of oocyte maturation; localized at the meiotic spindle and spindle poles during meiosis (PubMed:27753540). At 7.5-9.5 dpc expressed evenly all over the embryo. At later stages, expression is mainly restricted to proliferating zones. The highest levels of expression at mid-embryonic development (13.5 dpc) were observed in the liver, lung, kidney and back (trapezius) muscle and all regions in active proliferation
+Expressed in the inner cell mass of 4.5 dpc blastocysts, as well as in the polar trophoblast. At 6 dpc, abundant in the extraembryonic ectoderm and the ectoplacental cone. At this stage, not detected in the embryonic ectoderm. At 7 dpc, restricted to the extraembryonic ectoderm and the ectoplacental cone. Also expressed in the placenta. Expressed in male germ cells undergoing meiosis
+Preferentially expressed in both sexes during gametogenesis
+Strongly up-regulated in K562 cells treated by PMA to promote megakaryocytic differentiation, but not when treated by DMSO to promote granulocytic differentiation or by hemin to promote erythroid differentiation (at protein level)
+Expression first detected in somites at embryonic stage 24 (26 hours). At stage 29 (35 hours), expression is detected in the spinal cord. In stage 30 embryos (36 hours), expression is down-regulated in somites and up-regulated in spinal cord. By stage 35-36 (50 hours), expression is limited to dorsal spinal neurons of the spinal cord
+During seedling growth expressed on the inner side of apical hook
+During early pregnancy, uterine expression is markedly increased at 1 dpc and 2 dpc, with levels decreasing from 3 dpc onwards
+Detected in cochlea after 14.5 dpc. Detected in the spiral limbus in neoneates at 2, 8 and 12 days after birth, before the onset of hearing
+Expressed strongly during the L1 and L2 stages of larval development, but expression is weaker during the subsequent L3 and L4 stages of larval development and during the adult stages of development
+Detected in embryonic vasculature at 8 dpc. Detected in endocardium and the primitive ventricle at 9 dpc. First detected in myocardium at 11.5 dpc. Highly expressed in heart and lung at 15.5 dpc and in neonates, wherease expression in vasculature is no longer detectable
+Expressed in green leaves but fades out during senescence
+Accumulates in late G1 phase, levels rise during S phase and drop in early mitosis
+Localizes in the basal compartment associating with spermatocytes in all stages of the spermatogenic cycle. Detected at the site of elongate spermatids in stages XII-XIV in addition to being found in the basal compartment in these stages
+Preferentially expressed in postembryonic development
+Expression starts around 11.5-12.5 dpc. At 11.5 dpc, detected in the outer layer of the telencephalic vesicles. This pattern of expression continues until 17.5 dpc with expression in the cortical plate, but not in the inner layer of the cerebral cortex, including subplate, ventricular zone, and subventricular zone. As also detected in the hippocampus, amygdala and widely in diencephalic nuclei
+Expressed in bloodstream form
+Expressed during bone development and in adult parathyroid glands. Expressed at 11 dpc in the caudal part of the tongue and the umbilical cord and the expression in the tongue was maintained throughout adulthood. Expression increases in bone and cartilaginous forming zones of embryo up to stage 14.5 dpc and at 16.5 dpc expression is seen in the lung
+Expressed at the L1 larval stage in five neurons of the ring ganglia; a dorsal neuron, ALA, and four ventral SIA neurons (SIADR, SIADL, SIAVR and SIAVL) (at protein level) (PubMed:10887091). Earliest expression is at the end of gastrulation (PubMed:10887091). Expressed at the comma stage, in two dorsal neurons in the head, and in six cells on the ventral side of the head, just anterior to the excretory pore (PubMed:10887091)
+Expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head and limbs
+Detected as early as 4.5 months gestation
+Induced by seed imbibition with a peak after 1 hour and then steadily decreases to be barely detectable at day 3
+Embryos (at protein level) (PubMed:33602059). Detected in embryos and adults (PubMed:9376324)
+Early stages of flower development
+Detected in embryo at stage 13 in the posterior spiracles and foregut primordium. By stage 15, expressed specifically in epithelia secreting cuticle, including the trachea, foregut, hindgut and epidermis
+At 9.5 dpc it is expressed in the nephric duct, the dorsal neural tube, the epithelia of the branchial arches, and the optic vesicle. In 14.5 dpc embryos, like in earlier ones, it is expressed in the dorsal spinal cord and the brain, where it is restricted to the proliferating ependymal and cortical cell layers. Expression is also detected in smooth muscles of the digestive tract as well as in the epithelia of the salivary gland, the inner ear, and the developing nephrons of kidney. In early embryos, it is expressed in the epithelium of the branchial arches. At 14.5 dpc, Emu1 is restricted to the epithelium in the advanced developing kidney (at 15.5 dpc and later), transcripts are detected in the epithelium of the developing nephrons and in the collecting duct epithelium
+Expressed during all stages of postnatal retinal development
+In germinating seeds, present in the root tip and in a linear array of up to 20 to 30 cells above the root tip. Strongly expressed in the inflorescence apex, and, to some extent, in the inflorescence stem, the vascular tissue, and the vascular tissue in leaf primordia (PubMed:11743113). In flowers, expressed in sepals, style, receptacle, anther filaments, and connective but not in anthers themselves (PubMed:15722475)
+Expressed only in the bloodstream form of the parasite
+Highly expressed during gastrulation
+Expressed in neuronal cells, initially in embryos after gastrulation, including ventral cord motor neurons during the L1 larval stage, FLP, AVM and HSB neurons during L2, and PVM neurons during L3 (PubMed:11274062, PubMed:12954713). Expressed in the BAG neurons at the L2 and L3 stages of larval development (PubMed:25395666). Expressed in the HOB neuron beginning at the larval L4 stage and continuing throughout adulthood (PubMed:12954713). Expressed in the Q neuroblast lineage during larval development (PubMed:23946438, PubMed:11274062)
+Expressed in lens cells at 12 dpc. Expressed in the cartilage of ribs and limbs, in the eyes and spinal cord at 15 dpc. Expressed in the outer equatorial epithelium and lens fibers at 16 dpc (at protein level). Expressed throughout the lens fiber cells at 13 and 16 dpc; not detected in the epithelium of the lens. In the eyes, confined to the lens; not detected in the retina at 15 dpc. In spinal cord, expressed in the dorsal and ventral part of the dorsal horn at 15 dpc. Predominantly expressed in post-mitotic cells
+It appears in roots within 30 minutes of induction, maximum levels are reached by 6 hours, and remains constant for 2 days. In leaves it is seen 9 hours after induction, and reaches maximum levels after 24 hours
+Maternal expression is localized to the animal hemisphere where it persists through early cleavage stages. Initial zygotic expression is detected in the developing neural tube and becomes localized to the hindbrain and midbrain. Expressed in the primordium of the pronephric kidney and expression persists in the pronephric tubules and duct throughout development
+Expressed in the devoloping ovary. First detectable at stages 3 and 4 of oogenesis but remains very faint until stage 5, when the protein level increases substantially. In stages 4 to 6 is visible throughout the oocyte cytoplasm but is enriched at the osterior pole of the oocyte. During stages 7 to 9 is abundant in the oocyte cytoplasm, with some enrichment at the anterior of the oocyte and around the oocyte cortex. In stage 10 and in later stages is expressed at high levels in the nurse cells (at protein level)
+Detected in syncytial embryos and larvae (at protein level)
+Expressed in the brain at 16 dpc, 18 dpc, P2, P8 and P90
+Detectable at low levels from birth, up-regulated at day 14 coincident with the appearance of pachytene spermatocytes, then maximal from day 18 coincident with the appearance of haploid germ cells (PubMed:25781171)
+Expressed in skin and hair germ cells at 19, 20 and 21 dpc
+Predominantly expressed in late stage germ cells, pachytene spermatocytes and round spermatides
+Expressed throughout anthers from stages 8 to 12. Later confined to distal region of anthers from stage 13
+Expressed in all developmental stages, with a gradual increase in expression from the 2-day tadpole stage onward
+Expressed in developing embryos and dry seeds, and decreases rapidly during seed germination
+Expressed at all developmental stages in males and hermaphrodites (PubMed:23843623). Expressed at low levels in embryos and L1 stage larvae (PubMed:23843623)
+Found in embryos from 3 dpc to adult stages
+During embryo development, expressed in the brain
+Expressed both maternally and zygotically during embryonic development. Zygotic expression starts during early embryonic cleavage
+Expressed at the late gastrula stage, in 2 cells of the oral ectoderm
+Expressed from 1 to 5 days after seed imbibition (at protein level)
+Up-regulated during plasma cell differentiation
+Specifically expressed in unsegmented paraxial mesoderm and its immediate progenitors and sharply down-regulated in presumptive somites. Not detectable at 6.5 dpc. At 7.5 dpc, expressed mainly in the posterior region of the embryo, lateral to the primitive streak where presumptive progenitors of paraxial mesoderm reside. Expression is largely excluded from the midline of the primitive streak. No expression is detected in the anterior part of the embryo. At 9.0 dpc, highly expressed in the caudal presomitic mesoderm. At 11.5 dpc, the primitive streak completely regresses, expression is observed exclusively in the tailbud. Expression remains in the tailbud until 13.5 dpc and begins to disappear between 13.5 and 14.5 dpc when the tailbud loses its potential to provide paraxial mesoderm cells
+Expressed both maternally and zygotically from oogenesis through to late embryogenesis at a constant level
+Expressed in the ADL precursor cells in the precomma stage embryo (PubMed:29672507). Expressed during embryogenesis, larval stages and in adult animals (PubMed:27487365, PubMed:29672507)
+Expressed during the asexual blood stage, with highest levels in the late schizont stage
+During embryogenesis, expressed in embryos and suspensors from the one-cell stage to the four-cell stage. Expressed in the embryo until the torpedo stage
+Appears on embryonic day 18 and gradually increases until birth
+In seedlings, expressed at low levels in the petioles (at protein level) (PubMed:25794936). In young plants, mainly expressed in the roots, particularly in the tips and primordia of lateral roots. In flowering plants, first observed at high levels in young buds of the inflorescence (at protein level), later detected in reproductive tissues, such as pollen grains and ovules. In developing seeds, accumulates specifically at different stages. At globular stage, mostly present in outer integument, but also in endosperm and embryo. At the heart stage, only observed in endosperm and embryo. From the linear mature cotyledon stage until mature seed, accumulates in outer integument and in micropylar endosperm. Detected at low levels in senescent leaves (at protein level) despite a high transcription induction during senescence (PubMed:25794936)
+Up-regulated upon sporulation
+Isoform 2 is exclusively expressed at 7-11 days of development. Isoform 1 is found only at low levels in 15-17 days embryos
+Concentrated in the streaming cytoplasm in just-fertilized eggs. Evenly partitioned during cleavage among all blastomeres. Absent in the yolk cell during cleavage, blastula and gastrula stages. Distributed homogeneously among all cells of the gastrula
+Expression is first detected in the prechordal mesoderm of stage 4 gastrulas
+Expression is low before postnatal stage on day 20, and increases significantly between days 20 to 28
+Mainly expressed in neurons and later in midline glia during ventral nerve cord (VNC) development (at protein level)
+Up-regulated 12 hours after imbibition
+Low expression throughout the imaginal disks of third instar larvae with higher levels of expression at the anterior-posterior boundary (at protein level) (PubMed:15708564). Detected in the germarium and stage 2 and stage 3 egg chambers (at protein level) (PubMed:16507588). From stages 2 to 8, expressed in the follicle cells at the anterior and posterior poles of the egg chambers (at protein level) (PubMed:16260500, PubMed:16507588). From stage 4 to the end of oogenesis, only detected in follicle cells that are in contact with the oocyte (at protein level) (PubMed:16260500, PubMed:16507588). From stage 11 expressed at the apical surface of several embryonic tubular organs including the salivary glands, trachea, foregut and hindgut (PubMed:24718992)
+At 14.5 dpc expressed in lung, esophagus, skin and kidney. At 9.5 dpc expressed in foregut and surface ectoderm but not in the neural tube. At 9.5 dpc and 15.5 dpc, detected in the lung epithelium and in branchiolar and alveolar epithelial cells at 18.5 dpc and adult. Expressed in otocyst at 11.5 dpc, prominent in epithelial derivatives of the otic placode in the vestibule and cochlear duct at 18.5 dpc. At postnatal day 5, epithelial cells of the cochlear duct, which surround the endolymph-containing scala media, continued to express low levels, while little or no expression was seen in the mesenchyme-derived cells lining the scala tympani and scala vestibuli. Detected in cholangiocytes in postnatal day 1 and postnatal day 8 livers
+Broadly expressed from 9.5 dpc to at least 15 dpc, with slightly elevated levels in the developing nervous system
+At 8 dpc, expression is restricted to cardiogenic cells. At 10 dpc, expressed in heart and rostral somites. At 13.5 dpc, expressed in heart and skeletal muscle (at protein level)
+Expressed both maternally and zygotically. Expressed at the 1 cell stage (0 hpf) but disappears by the 2 cell stage. Expressed again from the 16 cell stage onwards. Embryonic expression increases dramatically around the hatching period. High expression then continues until 6 dpf, before declining
+Undetectable in early stage 1-8 egg chambers and present at very low levels in stages 9-10B egg chambers. Strongly increases in stage 12-13 egg chambers and remains high in mature stage 14 oocytes (PubMed:18020708). Protein levels drop dramatically by the time meiosis is completed in unfertilized eggs (at protein level) (PubMed:18020708)
+Expressed during embryogenesis through to adult stages with highest expression at later half of embryogenesis and during larval stages
+Expressed in lung at 12.5 and 16.5 dpc and declines thereafter. Expressed in epithelial cells of the bronchus and smooth muscle of the pulmonary artery at 13.5 and 16.5 dpc
+At 14.5, expressed within the retina outer neuroblastic layer
+Expressed in the basal cells of the tongue epithelium at birth until P20 (PubMed:32758484). Expressed in the suprabasal cells of the buccal mucosa and esophagus at P20 (PubMed:32758484)
+Expressed zygotically shortly after the midblastula transition (MBT). Expression remains constant till gastrulation then rapidly and transiently increases to peak during neurulation. Expression disappears by tailbud stages
+First detected at the two somite stage. Detected in intermediate mesoderm
+Expressed at stages 1 and 2
+At 14.5 dpc, expressed in lung epithelium and mesenchyme. At 16.5 dpc, expressed in esophageal epithelium and mesenchyme. In the caudal digestive tract, detected in small intestine epithelium at 14.5 dpc. Also detected at 14.5 dpc in epithelium and mesenchyme of trachea, ovary, kidney and stomach. In the developing skeleton, expressed in developing rib perichondria at 14.5 dpc. Also expressed in the neural tube and dorsal root ganglia at 14.5 dpc. In developing skin, expression is restricted to basal layers of the epidermis at 16.5 dpc
+High levels from 5 to 20 days after germination (at protein level)
+Expressed during in vitro differentiation of bronchial epithelial cells. In fetal lung, expression is barely detectable at 10 weeks post-conception but is strong in airway epithelium at 12.3 weeks post-conception
+Expression is detected at 4.5 hours post-fertilization (hpf) (PubMed:25463516). During development, weakly expressed in the brain, with some expression detectable in the telencephalon and diencephalon (PubMed:25463516). In the spinal cord, expression is restricted to an array of large dorsal neurons and small clusters of ventral neurons, likely Rohon-Beard cells and primary motoneurons, respectively (PubMed:25463516)
+Present in the 4-cell stage (PubMed:33277378). Expression is enhanced in early morula and late morula stage embryos (PubMed:33277378). Down-regulated during the first differentiation to form inner cell mass and trophectoderm within a blastocyst (32-cell stage) (PubMed:33277378)
+First expressed at stage I of oocyte development, and is maximally expressed at stage II. Levels decline during oocyte maturation and after fertilization, and also in the early neurula. Levels increase dramatically during the late neurula stage reaching a maximum at the tail bud stage
+In the embryo of stage 11, expressed predominantly in the head mesenchyme surrounding the brain and in the paraxial mesoderm. Highly expressed in presomitic mesoderm and then over the entire epithelial somite. During somitic differentiation, expression becomes restricted to the sclerotome. In the developing lens, expression is most active at the beginning of lens fiber cell differentiation
+In spleen levels are higher in adult than in fetal tissue
+Overall, expression is high in extraembryonic tissues, and low in somatic tissues. Expression starts between 8-cell and blastocyst stages. At 7.5 dpc, highly expressed in the ectoplacental cone and, at much lower levels, in the embryonic and extraembryonic ectoderm. At 14.5 dpc, highly expressed in placenta and, at much lower levels, in the yolk sac. Expression in other tissues, including brain, heart, liver, kidney, gut and genital ridges, is very low. Expressed preferentially from the paternal allele in blastocysts, in various tissues at 7.5 dpc, as well as in yolk sac and placenta at 11.5 and 14.5 dpc. Biallelically expressed in brain and other somatic tissues at 11.5 and 14.5 dpc
+In 3T3-L1 cells, sharp decline at mRNA and protein levels upon induction of adipocyte differentiation. Isoform 2 is detected in the immediate vicinity of vessels among small clusters of CD45(+) cells as early as 12.5 dpc. At 16.5 dpc, isoform 2 is expressed exclusively in tight clusters of cells found in lymph node anlagen, in the submucosal region of the intestine and around central vessels in the spleen
+Expressed during sporulation, under the control of SigK and GerE. Transcription begins 4 h (T4) after the onset of sporulation
+Activity was highest in chloroplasts isolated from young, actively dividing leaves
+Expressed at a constant level throughout oogenesis and in the egg. Levels decrease during gastrulation and are not detectable by the end of gastrulation
+Expression peaks 2-8 hours after egg laying. Expressed in the dorsal domains of gastrulation stage embryos. During mid-embryonic development, expressed in the central nervous system, the three thoracic segments and the cardiac precursor cells
+Preferentially synthesized during differentiation from meronts to sporonts in early sporogony
+No protein detected at any developmental stage, probably due to low expression levels (PubMed:31134275). At transcriptional level, is found in the larval stage (PubMed:31134275)
+Expressed in scattered solitary ovoid or bipolar cells among the oral epithelium from day 1-7, but with higher frequency in the soft palate as compared with the nasoincisor, circumvallate, and foliate papillae at day 1. During the second week, the solitary cells could no longer be recognized while cells expressing GNAT3 within the taste buds gradually increased. The onset of taste transduction accomplished by the palatal taste buds developed earlier than that achieved by taste buds in the circumvallate and foliate papillae
+Not developmentally regulated
+Embryonic expression was first detected in the node at 7.5 dpc. By early somite stages, expression extends anteriorly along the entire length of the notochord and is expressed in the dorsal neural tube from the caudal hindbrain to the posterior-most region of the embryo. By the time cranial tube closure is completed expression is continuous along most of the dorsal midline of the neural tube, to its rostral termination at the base of the forebrain. Expression in the neural tube and caudal notochord remains unchanged during early organogenesis from 9.5 dpc to 10.5 dpc
+High activity in cortex at embryonic stage 16 and postnatal day 2. Low activity in cortex from postnatal day 5
+Expression peaks at 10 dpc
+Increases in the third week postnatal and gradually increased until the adult stage (PubMed:27488028)
+Only expressed in sentinel 'S cells'
+Regulated in a cell-cycle dependent manner, with lowest levels in quiescent cells or at G1 phase. Progressive up-regulation starting at S phase and peaking at G2 and G2/M phases, followed by a drastic drop as cells exit mitosis (at protein level)
+Activity levels increase 5-9 days after imbibition in the hypocotyls and within 3-9 days in the roots. Detected in dry seeds but increased levels observed 5 days after seed imbibition
+Expressed both maternally and zygotically. Highest levels in early embryogenesis (0-6 hours), low levels during later embryogenesis, moderate levels in pupae and adults
+Expressed in the nervous system at 14.5 dpc
+Expressed during development. First detected at 3 hours of development. Levels increase during aggregation and peak at 6 hours. Levels decrease after tight aggregate formation
+Expressed in late embryos and disappeared by early larval states to reappear in the early pupae
+Expression begins at late gastrula/early neurula stage and increases towards the end of embryogenesis
+First seen in the tips of young rosette leaves. In older leaves and during their concomitant sink/source transition, expression proceeded from the tips to the bases of the leaves
+Expression begins at early stages of silique development, peaks in the second half of this process and decreases after the start of desiccation
+Only at larval stages
+During seed development, gradually down-regulated towards the onset of ripening (veraison). During berry skin development, dramatic decrease to full repression at veraison, followed by a slight increase towards ripening. In flowers, barely detectable in stamens, at the interface of filaments and anthers
+Detected in the lateral wall of the otic vesicle at 10.5 dpc. Enriched in lateral pouch epithelium at 12.5 dpc
+Expression begins at early neurula stage in the anterior neural plate whereas, at late neurula stage detected in the area which gives rise to ventral telencephalic and diencephalic regions and the eye. After neural tube closure and evagination of the optic vesicles at the early tail-bud stage, expression is specifically restricted to anterior and ventral neural structures, namely the ventral part of the optic vesicles and the ventral regions of the forebrain vesicle. This expression pattern is maintained during subsequent developmental stages. In tadpole embryos, specifically expressed in the ventral regions of both telencephalon and diencephalon
+Detected in embryos of all developmental stages, with high level at the 7 day stage
+Starts to be expressed during the S phase, reaches a peak at mitosis and then decreases
+First observed in the inflorescence meristem (IM) and young flower buds (PubMed:23335616). Detected throughout the floral bud. In young flowers, restricted to the inner whorls, specifically the petals, stamens, and carpels (PubMed:18417639, PubMed:23335616). In older flowers, present in the petals, stamen filaments and carpels, with weaker expression in the anthers of the stamens (PubMed:18417639). Observed in anther locules, vascular strands, and ovules (PubMed:23335616). During imbibition, expressed in the endosperm, especially at the time of testa rupture. Later restricted to the embryonic root (PubMed:20844019). In mature embryos, observed in the cotyledons and hypocotyl. In young seedlings, mostly expressed in shoot tissues, including the tip, circumference, and vasculature of the cotyledons, the emerging leaves, the meristematic region, and the basal part of the hypocotyl, and, at low levels, in the primary roots. In older seedlings, accumulates in the green shoot tissues (PubMed:22811435)
+Expression starts at 8.5 dpc and increases from 13.5 dpc on. Still detected after birth
+Expression in testis starts at P21, and increases to reach a plateau at P27 (PubMed:10591629). Expressed in the flagella of sperm at all stages of development in the testis and epididymis (PubMed:23303679)
+Expressed in between seam cells at the lima-bean, 1.5-fold and 3-fold stages of embryonic development
+Expressed both maternally and zygotically. Expressed in all cells of early embryos. In late embryos and L1 larva, it is weakly expressed
+Expressed in the outflow tract and the atrioventricular canal at embryonic stage 12 and gradually reduced by stage 16 (at protein level)
+Expressed at stage 4 in the ectoderm, stage 5-7 in the nascent notochord and at stage 7 its expression decreases in the anterior part of the embryo. From stage 7-10 its expression is restricted to the dorsal folds of the neural tube and to rhombomere 2. At stage 10, it is expressed in the lateral plate endoderm and in the tail bud and by stage 11/12 it disappears in the neural tube, followed by a confined expression at stage 12 to dorsal neural tube and at stage 15 an increasing expression in the ectoderm
+Detectable in the germline from germarium stages onwards and becomes enriched within the oocyte during early and middle stages of oogenesis. In early stages, it is present in the nurse cell oocyte cluster. It is highly expressed in stage 1-6 egg chambers, expression ceases during stage 7 and cannot be detected in stages 8 and 9. During stage 10, it is reexpressed in the nurse cells
+At 14.5 dpc the expression is detected in developing murine lip, eyelid, palate, digit, tongue and hair follicles. Its expression is also observed in the long bones of the developing forelimb but not the hindlimb
+At 6.0 dpc, expressed in both the extraembryonic endoderm and extraembryonic ectoderm. After the beginning of gastrulation, expression remains extraembryonic, and is mostly confined to the visceral endoderm. At 8.5 dpc, expression appears within the mesodermally derived allantois, and is highly expressed in the epithelial layer of the yolk sac. At 9.5 dpc, expressed in the hindgut and adjoining yolk sac. At stage 10 dpc, appears to be widely expressed throughout the embryo with higher expression within the branchial arches and within intersomitic endothelial cells
+Expression of the SP38-40.a and B genes are different: the A gene is expressed throughout the larval fourth instar but considerably less in the prepupal stage, while the B gene shows the opposite expression pattern
+Expressed in embryo at 8.5 dpc onward. In the neural plate, expressed in the presumptive forebrain and midbrain and in rhombomere at 4 and 8.5 dpc. Expressed in the limb buds and in the ectoderm of the first branchial arches at 9.5 dpc. In the brain, expressed in the dorsal mesencephalon (tectum) and prosencephalon (presumptive isocortex) at 9.5, 10.5 and 11.5 dpc. In the cortex, expressed in dorsolateral patch of the neuroepithelium at 10.5 dpc. Expressed in the ectoderm of the branchial arch and the oral ectoderm at 10.5 dpc. In the limbs, expressed in the apical ectodermal ridge at 11.5 dpc. Expressed in the telecephalon, ventricles, diencephalon and medulla oblongata at 12.5 dpc. Expressed in the neural tube, cochlear ganglion and olfactory bulb at 14.5 dpc. In the kidney, lung and intestine, expressed in epithelial cells at 14.5 dpc
+Highly expressed at day 9 of embryogenesis. Expression decreases to moderate levels through day 13. In the developing embryo, expressed in the brain, somites and mesenophric tubules
+During development, it is expressed at highest level at 11 dpc
+Expression begins at stage 8.5, after the mid-blastula transition. Expression is highest at early gastrula stages and is maintained throughout neurula, tailbud and early tadpole stages
+Relatively high levels of expression in eggs and 1st instar larvae compared to pupal and adult stages, with weak expression in 2nd instar larvae (at protein level) (PubMed:16439308). Expressed throughout development in all somatic cells (PubMed:9199347). Highest levels of expression in embryos and weak expression in larvae and adults (PubMed:2186029, PubMed:9199347). Expressed throughout development (at protein level) (PubMed:2517292)
+Present in the 3.5 dpc blastocyst. Levels increase to a maximum between 18.5 dpc and birth and decrease gradually between birth and adulthood with the greatest decreases occurring between neonate and P1 and between P9 and P16 (at protein level). Expressed in the primitive endoderm at 4.5 dpc. At 9.5 dpc, expressed in midbrain, notochord, liver primordium, midgut and hindgut
+Detected at low levels in neonate blood serum. Levels increase throughout the first three weeks after birth
+First detected at 10.5 dpc with high levels near the midline region of the tectum and to a lower extent in discrete regions of hindbrain, the dorsal horn, of the spinal cord and in the naso-lacrimal groove. The expression decreases at 12.5 dpc and is barely detectable at 17.5 dpc. Not detected at postnatal stages
+Highly expressed in male PHC sensory neurons from the late L4 larval stage/young adult stage
+Expressed during flower development until 8 days after flowering
+Expressed from day 7-8.5 during feather morphogenesis in dermal and epidermal cells. Also expressed in heart from day 8.5-14.5. At later stages, when the feather follicle forms, expression still abundant in the epidermis, especially in the feather barb ridges
+Transcripts first detected at 15.5 dpc and peak 1 week after birth. Transcripts accumulate during oogenesis (PubMed:18804437). During meiotic maturation, the vast majority of the transcripts are degraded and virtually none is detected by 2-cell stage embryogenesis (PubMed:18804437). The protein however persists during preimplantation up to the blastocyst stage (PubMed:18804437). At 2-cell stage, excluded from cell-cell contact regions. Continuous exclusion from these regions during preimplantation development leads to the absence of the protein from the inner cells of the morula and the inner cell mass of the blastocyst (PubMed:18804437). Expressed in the forebrain, midbrain, ventricular zone and superficial cortical plate at 14.5 dpc (PubMed:16314515). Expressed in cortical progenitors in the forebrain dorsal telencephalon and the midbrain at 15.5 dpc (PubMed:16314515). Expressed in ovaries at postnatal day 2 (P2), expression peaks at P10, expression is then decreased at P17 and further decreased at P21 (PubMed:31575650)
+Expressed both maternally and zygotically. Shows a small amount of maternal expression. Zygotic expression begins at stage 8 and steadily increases after this point
+Localized to the primary synapse region in the vulva from early larval stage L4 to young adult stage
+Expressed at 16.5 dpc in brain, heart, lung, kidney and gut
+Expressed predominantly throughout the epiblast before gastrulation and declines as development progresses
+Expressed in the embryonic headfolds and to a lesser extent in the trunk of neurula at 10 dpc
+Expressed during Rhizobium-induced nodule formation. In 4-day old nodules it is found in a small cluster of cells in the primordium, and in this cluster infection threads are present. At day 5, expression is seen in the complete central tissue. At day 20 expressed in the complete prefixation zone II where it is only active in the infected cells, and maximal accumulation occurs in the proximal part of this zone. Levels decrease to a lower level from one cell layer to another at the transition of prefixation zone into interzone II-III and remains at this reduced level in the fixation zone III
+Restricted to the embryo and early larval stages
+Present during at least the first 5 days of germination
+First detected in the swimming blastula, maximally expressed in the gastrula. Levels decrease in the prism larval stage and are barely detectable by the pluteus larval stage
+Widely expressed in embryos, notably in skeletal and craniofacial precursors (PubMed:33012048). Expressed in mesenchymal cells or stromal cell from 10.5 dpc to 17.5 dpc (PubMed:15162516)
+Maternal transcripts localize exclusively to animal blastomeres. Active expression (mRNA level) in whole oocytes during early stages (Dumont I-II). Transcripts accumulate in the animal half during the latest stages of oogenesis (Dumont IV-VI). Localized in the perinuclear cytoplasm in the full-grown oocyte. Close association with chromosome movement in dividing blastomeres. After gastrulation zygotic expression is observed in the whole ectodermal region, but enhanced in the dorsoanterior region. In the tadpole, expression is observed in the central nervous system, eyes and branchial arches
+Is synthesized during the whole life span of honeybee
+Expression is first detected in the vegetal plate of the late blastula 17 hours after fertilization. In early gastrula, it is expressed in the archenteron. In late gastrula, expression is detected only in the distal portion of the archenteron and becomes undetectable by the end of gastrulation
+Maximal expression at days 17-19 of pregnancy
+Detected in all larval forms and adults, but is most abundant in the embryonic stage (PubMed:8510930). First expressed in the embryonic tail at the comma stage of embryogenesis (PubMed:16516839). In newly hatched larvae, it is expressed in four stripes of cells lining the dorsal and ventral posterior quadrants of the body (PubMed:16516839). Expression spreads anteriorly becoming restricted to the ventral side of the body as development progresses (PubMed:16516839)
+Expressed zygotically from gastrula stage (stage 11). Expression remains constant at later stages
+Expressed both maternally and zygotically. At least one isoform is present at each developmental stage
+Expressed both maternally and zygotically. Maternal expression decreases until the late blastula/early gastrula stage when zygotic expression begins. Expression is highest in the gastrula stage, after which it shows a gradual decrease, being clearly present until the tadpole stage
+Expressed both maternally and zygotically. Ubiquitous embryonic expression until the 100-200 cell stage then disappears by the 300-400 cell stage. Expressed again in L3 larvae through to adulthood
+Abundantly present in reproductive females but is present to a lesser degree in other female caste members (alate, virgin queens; and workers). Not expressed in males
+Barely detected in non senescent green leaves, accumulated slightly at the early stage of leaf senescence and strongly expressed at the late stage of leaf senescence
+Highest expression in late pachytene spermatocytes and postmeiotic round spermatids
+Strongly expressed in embryos from 9.5 dpc to 10.5 dpc. Expression is much lower at 11.5 dpc and virtually extinct at 15.5 dpc. Detected in neural tube and lateral mesoderm at 9.5 dpc. At 10.5 dpc detected in fore and hind limb buds and lateral plate mesoderm, throughout the neural tube, in mesencephalon and dorsal diencephalon
+Expressed in fetal liver. Expression decreases during differentiation of ES cells or upon induction of neuronal differentiation by retinoic acid
+The calB transcript is very low in vegetative cells, it accumulates to higher levels during aggregation and during slug formation. It is present in its highest level in spores
+Expressed throughout development, highest levels are in embryos and pupae
+Expression starts at 9.5 dpc
+Start to be expressed 1 day after germination (DAG) in the vascular tissue at the root-hypocotyl junction
+Protein expression is initiated from 6 and 12 hours of embryonic development
+To initiate infection, trophozoites emerge from a cyst in the host. Excystation is blocked by specific cysteine protease inhibitors. Vacuoles release it just prior to excystation
+In leaves, mostly observed in guard cells
+Expressed early in embryogenesis, with a high transcription rate at midmaturation and then decreases prior to seed dormancy
+Detected in the generative cell of bicellular pollen
+In the developing embryo, it is first detected at 7.5 dpc in the extraembryonic yolk sac, coincident with the appearance of blood islands. Later, restricted expression is seen in 14.5 dpc fetal liver, the primary source of erythrocyte production in mid-gestation. Expression decreases in the spleen around 4-5 weeks of age, suggesting that it is decreased during splenic lymphocyte maturation
+In embryos, expressed ubiquitously with higher expression levels in the central nervous system and muscles (at protein level). Expression levels decrease from the embryonic to larval stage (at protein level). In third-stage larva, high levels of expression in the epidermal cells with lower levels of expression in the muscles, central neurons and peripheral axons (at protein level)
+Expression starts around 72 hours after pupariation, peaks 12 hours after eclosion and decreases thereafter to undetectable levels by 3 days after eclosion
+Temporally expressed during flower development
+Aggregates of epg-2 peak in abundance at the 100 cell stage then decrease until they are very few at the comma stage (PubMed:20550938, PubMed:28806108). Absent from the 200 stage onwards (PubMed:24140420, PubMed:28806108)
+Strong levels in the ventral node from the early bud to the four-somite stage. Expression is enriched in the perinodal crown cells and become asymmetric at the three-somite stage
+Low levels detected in the unfertilized eggs, newly fertilized eggs, 16-cell stage and morula stage embryos. Higher levels detected in the blastula, gastrula and neurula stages. Higher levels also detected during the lens formation stage, somite and hatching stage. The expression levels continue to increase during development and peaks at 30 day old larvae, and then gradually decreases to lower levels again in day 60 larval stage
+Widely expressed at 10.5 dpc to 16.5 dpc
+Detected in fetal epidermis from 49 to 135 days estimated gestational age (at protein level)
+Maternally expressed. Widely expressed in the early embryo and concentrated in the head by 48 hpf
+Expression is detected at the start of the premolt period and accumulates during this period from D1'b to D3. After ecdysis, expressed in the postmolt period but at much lower levels. Not detected in the intermolt period
+On embryonic days 15 (15 dpc) and 18 dpc, expression is seen in the mantle and ventricular germinal zones throughout the neuraxis. On postnatal days 0 (P0) and P7, expression is seen in the cerebral neocortex, olfactory mitral and granule cell layers, hippocampal pyramidal and dentate granule cells and the striatum. A lower expression is seen in gray matter in di-, mes- and met-encephali. In the cerebellum, the expression is evident in the external and internal granule cell layers and Purkinje cell layer. On P14, a decreased expression is seen in the di-, mes- and met-encephali. On P21 and thereafter, expression is seen in the olfactory mitral and granule cells, dentate granule cells and the cerebellar granule cells and Purkinje cells
+Expressed in 17.5-day-old embryos
+Expressed in the early gut and pancreatic epithelium, at 15 dpc day localized to cells that will eventually become exocrine. Expressed in choroid plexus, developing myocardium, pancreatic epithelium and dorsal root ganglia
+Expressed at all developmental stages (PubMed:9152019). Expressed in embryos (at protein level) (PubMed:16543150)
+Present in oocytes
+Expressed during the G1-S phases of the cell cycle
+Expression in different brain regions during development is correlated with the progression of myelin formation. Isoform 5 seems to be the most abundant spliced form expressed during development. Expressed at P7 in optic nerve, at this time point, the first compact myelin is formed. At P9 abundantly expressed in the optic nerve
+Expression rises between 7 and 12 d.p.p. and remains steady through adulthood
+First observed in siliques 15 days post anthesis and accumulates progressively as native isoforms or proteolytic fragments during the last week of seed maturation/desiccation. Present in dry seeds, but disappears during their germination (at protein level)
+Expressed in neural tissues at the neurula stage, and in the restricted region of the tadpole brain
+Expressed in the developing forebrain, diencephalon, midbrain, hind brain and spinal cord at Carnagie stage 16 (CS16, 6 weeks of gestation) and CS21 (8 weeks)
+First detected in the central domain protodermal cells when cotyledon primordia become recognizable, at the early globular stage. Later observed throughout the central domain and basal domain of the embryo proper. After bolting, localized in axillary buds and premature anthers. Abundant in the tapetum of wild-type anthers during microspore maturation
+Expressed in the early stages of embryogenesis
+Meiosis-specific. Expressed during meiosis II, from 3 to 9 hours after induction of sporulation. Not expressed during mitosis
+Expressed in fetal erythroid tissue
+Expressed in the ventral spinal cord as early as 9.5 dpc. Expression becomes progressively restricted to a narrow zone within the ventral neuroepithelium of the spinal cord. In the 14.5 dpc spinal cord, expressed in the oligodendrocyte progenitors of the ventral ventricular zone, but not dorsal root ganglia Schwann cells. Also expressed scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. In the brain, from 10.5 through 14.5 dpc, expressed in numerous cells in the ventricular and subventricular zones of the lateral and medial ganglionic eminences, suggesting that expression might not be limited to the oligodendrocytic lineage. By 15.5 dpc, dispersed throughout the gray matter, with little or no residual expression in the ventricular zone. In the postnatal brain, present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Expressed in the 13.5 and 14.5 dpc retina and in the olfactory epithelium from 11.5 dpc onward
+Barely detectable at 11 days postpartum (dpp), very strong signal from 20 dpp until adulthood (PubMed:19204925). Expressed from the mid-pachytene spermatocyte stage to the early elongating spermatid stage (PubMed:17664285, PubMed:19204925)
+Expressed from L1 larval stage through adults
+Expressed at a relatively low level during growth, increased 80-fold during early development, with a maximum during the growth phase at 12 hours, and quickly declined fourfold during 12 and 15 hours
+Zygotically expressed. First detected 1 h after the midblastula transition. During gastrulation, expression is restricted to ventral regions. Later, expressed in the somites, eyes and a subset of dorsal cells in the hindbrain. Levels increase until the end of gastrulation and then remain high
+Expressed very early in the exponential growth phase
+The non-sex-specific transcript is present at all stages
+Strong expression in neural crest cells and in later stages in different gastrointestinal organs
+Expressed in neural progenitor and neuron cells throughout the developing nervous system. Expressed in somites and throughout the neural tube from 8.5 dpc, onward
+Expressed in embryos, larvae and adults (PubMed:22426883). In embryos, expression begins at the end of gastrulation after the first cell cleavage (PubMed:22426883)
+Expressed during embryogenesis (at protein level). Isoform A is expressed in ovaries and 0-1 hour embryos. After 2-3 hours unphosphorylated zygotic protein is expressed. Between 4-8 hours phosphorylated zygotic protein is expressed. After 12 hours the amount of unphosphorylated zygotic protein increases until, by the end of embryogenesis, it is the most abundant form of cactus
+Expressed both maternally and zygotically. Expressed at a low level maternally, with expression strongly increasing with the onset of gastrulation, then decreasing again in later stages of embryonic development with expression undetectable during neurulation. Expressed in adults
+Expressed in developing and differentiating ciliated sensory neurons of both the chordotonal (Ch) mechanosensory neurons and external sensory (ES) cells
+First detected in the trunk, in discrete regions of paraxial mesodermal segmental plate at 12 h of devel-opment (6-somite stage). In older embryos a weak diffused staining is found, even in unsegmented presomitic mesoderm. Expression, probably located in myoblasts, proceeds in a rostro-caudal sequence according to the state of differentiation of the somites. Initial narrow staining progressively enlarged in the differentiating somite. At all stages, the ventral part of anterior somites showed more intense staining than the dorsal part. In the posterior brain expression and activity appear after 14 h. At 24h, detected in all primary neurons in the brain. Expression in cranial ganglia can be detected in whole embryo until about 36h. Expressed also in a sensory system in anterior and posteriorlateral line ganglia as seen in the embryo at 24h. In addition the heart shows strong expression from its early morphogenesis
+Expression is sharply reduced in leaves during leaf senescence
+Expressed in the central portion of the morula, the inner cell mass (ICM) of the blastocyst, in embryonic stem (ES) and embryonic germ (EG) cells, in the epiblast between 6.5 and 7.5 dpc, in primordial germ cells (PGCs) between 7.75 and 12.5 dpc (at protein level). The expression in PGCs decreases in female germ cells that entered meiosis at 13.5 dpc and in male germ cells that entered mitotic arrest at 14.5 dpc (at protein level). Not expressed in unfertilized eggs or 2- or 8-cell-stage embryos (at protein level). Expressed in the central portion of the morula, the inner cell mass (ICM) of the blastocyst, in ES and EG cells, in the epiblast at 6 dpc and in PGCs of genital ridges between 11.5 and 12.5 dpc. Expression decreases with ES differentiation
+In flowers, observed at the anther/filament junction region and in female gametophytes (PubMed:25593351). Probably present in the embryo sac and the stigma (PubMed:25593351)
+The embryo-specific isoform is expressed during the syncytial blastoderm stage. Expressed only in chromosomal female embryos
+Expressed at the time when separation of neural and epidermal precursors cells occurs. Expressed within neuronal cells in the embryo. Later in development, accumulates within the developing central nervous system. After germ band retraction, found in brain, ventral nerve cord and in presumptive peripheral nervous system
+Found in the germinal vesicle (GV) oocyte and diminishes constantly throughout embryonic development. The levels compared to the initial amount found in the GV oocyte decreases to 41%, 28% and 7% in the 2, 4, and 8-cell embryos. In the 16-cell embryo and blastocyst, respectively, levels are 200 and 2000 times lower than in the GV oocyte
+Expressed in sporozoites and in the late mature liver stage (at protein level) (PubMed:32866196). Expressed in the merosome, a membrane-surrounded vesicle which contains mature merozoites and produced at the end of the liver stage (at protein level) (PubMed:32866196)
+In trophozoites, schizonts, and merozoites
+Expressed in 4-cell embryo, morula and blastocyst. At 7.5 dpc, detected in the epiblast. At 10.0 dpc, expressed in the primordial germ cells and at 12.0 dpc in the embryonic gonads. At 14.5 dpc, expression is restricted to testis. 6 days after birth, still detected in primitive type A spermatogonia. Expressed in undifferentiated embryonic stem cells, but expression decreases upon differentiation (at protein level)
+On 9.5 dpc expressed in the trigeminal (V) ganglion. On 10.5-11 dpc, expressed in the eye, second branchial arch and the dorsal root ganglion. On 11.5-12 dpc, expressed in the lens and neural epithelium of the eye. On 14-16 dpc, expressed in the sympathetic ganglon and dorso-lateral mesenchyme near the developing ear
+Probably maternally supplied, the zygotic expression is detected early during development at the 512-cell stage and is stable until 24h hpf at least
+In flowers, expressed in stigmatic papillae, anthers, pollen grains and floral abscission zones. As flowers mature, progressively restricted to the abscission zones and the septum of the siliques. During seed development Mainly detected in seeds endosperm layer until the fourth day after germination. In young seedlings, confined to the cotyledons. Later observed in roots, especially in vascular organs and at branching points of lateral roots. In adult leaves, particularly localized in vascular tissues and hydathodes; mostly present in both young and senescent leaves, tissues undergoing developmental transitions
+Constitutively expressed at low level during leaf development, but up-regulated during seed maturation and senescence, when the leaf color changes from green to yellow
+Widely expressed during maturation of oocytes. Also expressed in embryos from gastrulation onwards in the yolk syncytial layer and somites. Expression declines in the somites, but is up-regulated in the yolk syncytial layer throughout embryonic development
+Detected from 5 dpc onward in the neuroretina (at protein level)
+Detected at all stages of development and more abundant in the latter period
+Highly expressed in vegetative cells; expression decreases approximately 3-fold during the aggregation stage, and then increases again during the later stages of development (mound, finger and slug)
+In the brain cortex and in the hippocampus, continuously expressed from P0 to adult age (at protein level)
+Not detected at postnatal day 1. Expressed on subsequent postnatal days up to day 20 and throughout adulthood
+Expressed at larval stages L2, L3, lung L3 and in adults (at protein level)
+Up-regulated in adipogenesis and also markedly up-regulated during in vitro myogenesis of C2C12 myoblasts to myocytes
+During embryogenesis, expression in found in all stages examined, with the highest levels of expression at early stages (8.5 dpc) and moderate levels of expression being found at mid- to late stages of embryogenesis. Expressed during early stages of skeletal muscle development. At embryonic stages 9.5 dpc and 10.5 dpc, expressed strongly in the dorsal somite (the structure of origin for skeletal muscle precursors). It is also expressed at later stages of muscle development;
+Expressed in both adult and embryo with highest levels in early embryogenesis. Expressed in the fertilized oocyte. Expression decreases during differentiation of ES cells and during senescence of MEFs. Expression increases in prostate during prostate tumor development
+Expressed in the developing embryo at the upturned-U stage
+Expressed in embryos of both sexes. Also expressed in the progenitor cells of the germline
+Highest levels at the embryonic stage, decreasing progressively during development, except for an increase at the L3 stage (PubMed:8514766). Expressed in hypodermal cells during elongation throughout the second phase of embryogenesis (PubMed:8824291)
+Initially observed in the analgen of the anterior and posterior midgut and the cephalic mesoderm. It is found in both the endodermal and mesodermal germ layers and for a brief period during gastrulation it is expressed in the amnioserosa. During germ band retraction it becomes restricted to the fat body
+Expressed in the brain during 14 dpc and 17 dpc
+First detected in 18-day-old mice (at protein level)
+In the cochlea, mainly expressed in the organ of Corti, along the entire cochlear length, at postnatal day 4 (P4) through P20. At P20, the expression becomes more restricted to the apical membrane of the inner border cells and the cell junctions of the inner sulcus cells. Throughout the early developmental period, up to P20, expression is mainly found at inner glia-like supporting cells of Kolliker's organ, while hair cell expression is comparably sparse. Expression in glia-like supporting cells is maintained in adulthood at 1, 2 and 4 months (at protein level)
+Widely expressed during embryonic development; at stages 9.5 dpc-10.5 dpc, expression is strongest in neural tissues. At 11.5 dpc-12.5 dpc, expression is abundant throughout embryonic tissues, being strongest in the developing liver, primitive gut, nasopharynx, and developing limb buds. Moderately expressed at this stage in the brain and optic stalk, branchial arch and urogential ridge. Expressed at a low level in the heart. By stage 13.5 dpc-14.5 dpc, expression is abundant in the forebrain, vagus nerve, dorsal root ganglia, nasopharynx, kidney, liver, pancreas, intestine, gut, thymus, lung, genital tubercle, tongue and lower jaw. Moderately expressed in the midbrain and expressed at a low level in the heart and large blood vessels. In the developing placenta, expression is moderate in the giant and spongiotrophoblast cell layers and strongest in the labyrinthine portion throughout 9.5 dpc-13.5 dpc
+In developing molars, it was first detected in alveolar bone in 19-day-old embryos. In more mature teeth (newborn and 2-day-old rats), the expression starts in the polarized odontoblasts and increases in the secretory and mature odontoblasts
+Highly expressed in the developing retina, at least since 13.5 dpc. Expression decreases afterwards and peaks again at postnatal day 14, and remains constantly expressed in the retina until adulthood
+Expressed both maternally and zygotically at all stages of fly development
+Detected from 24 to 72 hours post-fertilization (hpf)
+At 8.5 dpc and 9.5 dpc expression is restricted to forebrain mesenchymal cells
+First observed in the embryo at globular stage in cotyledons primordia and later confined to cotyledons tips and shoot apical meristem. Also detected in emerging leaf primordia
+In myogenic progenitor cells, highly expressed, at least as early as 11.5 dpc, expression decreases gradually until adulthood
+Required during the later half of pupal development for the normal pigmentation of the adult cuticle
+Expression transiently increases in siliques 4 hours after flowering
+Expressed in developing grain from 1 to 21 days after pollination
+Isoform 1 and isoform 2 are detectable in mammary tissue from non-pregnant animals, with isoform 2 being predominant. Levels of isoform 1 increase during gestation and lactation while levels of isoform 2 decrease
+Expressed both maternally and zygotically. Strongly expressed in the oocyte and in early embryos, then decreases at the end of embryogenesis. Weakly expressed in third instar larvae. Transiently required between 2 and 6 hours of embryogenesis to establish PcG silencing and promote viable adults
+Exclusively secreted by larvae, nymphs and adult male ticks
+Earliest inducible cell surface glycoprotein acquired during lymphoid activation
+Maternally expressed, it decreases at mid blastula transition and reappears at late neurulation. Expressed at higher levels in the anterior and dorsal regions of embryonic stages 16, 24 and 37. In adult it appears to be ubiquitously expressed with higher expression in brain and ovary. Expression in the brain, brachial arches, trigeminal facial ganglion, and the retina of swimming tadpole stage of development
+Expressed both maternally and zygotically. At 17 hours post-fertilization (hpf), expressed in dorsal Rohan-Beard neurons and strongly in the ventral myotomes. At 24 hpf, head expression is restricted to eyes, the tectal region of the midbrain, trigeminal ganglia and the ganglia anterior to the otic vesicles
+Increases as cells enter in S phase through G2/M phase. The protein has a short half-life (at protein level)
+Detected at the germinal vesicle (GV) stage. During maturation, decreases to barely detectable levels in meiosis I- and meiosis II-stage oocytes
+Within the bicellular pollen, only detected in the generative cell and not in the vegetative cell. Expressed during the S-phase
+First detected in significant amounts at postnatal day 2 (P2) and increases about twofold to a peak value at P17-P20 and declines significantly thereafter
+Expressed throughout germination. Increases during the initial 30 hours of germination, slightly decreases between 30 and 48 hours, and increases again at 60 hours, correlating with the proliferative activity of embryo cells
+Expression begins at embryonic day 9.5 in the developing spinal cord and brain structures and continues in neonatal and adult brain structures including the olfactory bulb, cortex, thalamus, hypothalamus, hippocampus and cerebellum
+Detectable in testis 4 weeks after birth, becoming more prominent thereafter
+Expressed during seed maturation (PubMed:10589521, PubMed:9816677, PubMed:21041098). Expression begins at 18 days after flowering (at protein level) (PubMed:9816677). Expressed in maturing seeds 2 weeks after flowering (PubMed:10589521). Decreases gradually after germination (PubMed:21041098)
+In the bone marrow, expression is limited to immature neutrophils. Expression was not detected in circulating mature neutrophils
+No significant expression was discerned throughout the prenatal brains except for the olfactory mantle zone, which exhibited the expression signals weakly. On P0 and P7, the expression was weakly positive in the gray matter throughout the brain, with higher expression in the olfactory mitral cell layer. In the cerebellum, the expression was evenly positive in external and internal granule cell layers. On P21 and P56, the expression in non-cortical brain parenchyma was negligible. However, the expression was evident in the olfactory mitral cell layer, the piriform cortex, the hippocampal pyramidal CA1-3, and the cerebellar Purkinje cell layer, although much less distinct in the dentate granule cell layer and the cerebellar granule cell layer. In the cerebral cortex, the expression was weaker in layer V than the other layers. No significant expression was seen in the white matter
+Expressed in callus 96 hours after initiation on callus-inducing medium
+Early postnatal
+Widely expressed in the developing brain from 9.5 day post coitum (dpc) to postnatal day 1 (P1) (PubMed:20844286). Specifically expressed in the thalamic reticular nucleus (TRN) at birth. Expressed in the striatum, cortex and cerebellum by P15 onwards (PubMed:27007844)
+Blastoderm specific
+High in late larvae and in adult
+Present in stage 1-4 embryos (at protein level)
+Expressed ubiquitously during early embryonic development. Expression is detected at 3 hours post fertilization (hpf) and reaches a peak at 20 hpf
+Two calmodulins are synthesized during differentiation of Naegleria gruberi from amoebae to flagellates; one remains in the cell body and the other becomes localized in the flagella. Flagellar calmodulin first appears during early stages of differentiation, is maximally expressed at the time that flagella first appear and then levels rapidly decline
+Expression in fetal tissues is significantly lower than in adult tissues
+Expressed throughout the mesenchyme of early limb buds. At later stages, present in the condensing chondrogenic mesenchyme, then the perichondrium. Down-regulated in areas that will not give rise to cartilage and is then lost from cartilage forming areas after they begin to differentiate
+In lens, first detected at 16 weeks when expression is weakly and uniformly distributed. Subsequently, expression becomes much stronger in the epithelium of the anterior part at 25 weeks and later. In retina, weakly expressed at 15 weeks in the nerve fiber and ganglion cell layers (NFL and GCL). From 25 weeks onwards, much stronger expression is observed in the endfeet of Mueller cells, the NFL, and GCL, and much lower expression is observed in a minor subpopulation of cells in the inner cell layer (INL). At 30 and 36 weeks, expression remains in the neural retina, and subsequently becomes stronger in the NFL, GCL, and INL and is decreased in Mueller cells. At 36 weeks, also expressed at the external border of the outer nuclear layer (ONL) (at protein level)
+Not detected in embryo. Isoform 1 is detected in testis at day 8 after birth while isoform 2 at day 17
+At 10.5 dpc, low level expression detected throughout the embryo with relative accumulation in spinal cord and brain folds. At 13.5 dpc, highly expressed in the CNS both in the ventricular (mitotic) and marginal (post mitotic) zones, in the PNS in dorsal root and trigeminal ganglia, and the developing gut. During development, expression in the central nervous system and peripheral nervous system persists, and expression in the intestine is further induced. Expression in the intestine is observed throughout the mucosal villi, which contains epithelial cells and other cell types. High expression is also detected in the lens. No expression is seen in other tissues such as liver, lung, bone, cardiac and skeletal muscles
+In flowers, expressed in the sepals and the style. In siliques, present at the base and tip
+In infected epithelial cells, is expressed late in the infectious cycle
+In the developing brain, expression begins by at least embryonic day 20, increases gradually through postnatal day 2 and day 50 and decreases by postnatal day 300
+Levels of expression in fibroblasts decrease heterogeneously during cellular aging
+Expressed in a variety of tissues from embryo to adult
+Expression is first detected is intestinal primordium at the embryonic stage 16 dpc followed by expression in future head neurons and head muscle cells at the comma and 1.5-fold stages (PubMed:20805556). Expressed in larvae and adults (PubMed:19297413, PubMed:20805556)
+Predominantly expressed in mesenchymal condensations throughout the embryo before and during the deposition of cartilage (PubMed:7704017). Expressed in multipotent skeletogenic cells (PubMed:9119111). Continues to be expressed during chondrocyte lineage progression, except in terminally differentiating growth plate chondrocytes (PubMed:9119111). Also expressed in some non-chondrogenic tissues such as notochord, otic vesicle and neural tube (PubMed:9119111). In the developing lung, expressed at the distal tips of the branching epithelium as branching occurs and is down-regulated starting at embryonic day (E)16.5, at the onset of terminal differentiation of type 1 and type 2 alveolar cells (PubMed:24191021)
+Ubiquitously expressed at 12 dpc and 14 dpc
+During the mid-pupal stage, strongly expressed in the lamina, medulla and inner optic lobe of the developing eye. Specifically detected in R7 and R8 axonal terminals in the medulla
+Expressed from the onset of gastrulation, beginning with the dorsal hyp7 cells. Subsequently detected in other cell types including hypodermal cells, neuronal cells near the pharyngeal bulbs, neurons along the ventral nerve cord, the AVM, HOA, HOB, PLM and VA3 neurons, some body wall muscles, and the ray cells. During the L4 stage, expressed within neuron A of all ray cells, neuron B of rays 3 and 6, and the structural cell of ray 6
+Expressed in embryonic ovaries at 14.5, 16.5 and 18.5 dpc (at protein level)
+Starts to accumulate in maturing seeds 15 days after pollination and decreases rapidly during seed germination
+Expressed at 8.5 dpc in the blood islands of the yolk sac and in the circulating primitive blood cells. Expressed in the circulating blood cells at 9.5 dpc and 10.5 dpc. Detected in the developing hepatic primordia at 10.5 dpc. From 11.5 dpc to 14.5 dpc, exclusively expressed in the fetal liver
+Specifically expressed late during asexual development
+Detected at low levels in growing cells. Levels are higher during development and decrease again at culmination
+Expressed in larva and adult male. Expression in the sperm nucleus begins between the early and late canoe stages before the protamines appear. Highly expressed from early spermatocyte to late spermatid and persists in mature sperm
+Expressed both maternally and zygotically. Expressed at a low level maternally, and abundantly expressed at stage 11 (mid-gastrula) and thereafter
+Expressed throughout development. Highest expression is in the embryos
+Adult-specific. Not detected in eggs or 1-week-old worms but abundant in 6-month-old worms
+Expressed from 24 hours post-fertilization (hpf) (PubMed:26542022). Expression increases between 24 and 72 hpf and then decreases towards 120 hpf (PubMed:26542022). In embryonic hearts expression peaks at 48 hpf and again at 96 hpf, decreasing at 120 hpf to levels then detected in adult hearts (PubMed:26542022)
+Expressed both maternally and throughout the embryo during blastula stage. During gastrulation and epiboly stages, strongly expressed in the mesendoderm of the germ ring. Expressed at the tail bud and in early somite stages in a horseshoeshaped population of ventral/lateral mesoderm cells that will give rise to blood. Detected in ventral-lateral mesoderm between the one- to three-somite stages and increases through early development. Expressed in lateral stripes of mesoderm at five somites. Expressed broadly in the brain, spinal cord, trunk, and tail mesenchyme, but is at much higher levels in hematopoietic cells of the blood island at 24-72 hours post-fertilization (hpf)
+Detected in embryonic forebrain at stages 12.5 dpc and 14.5 dpc where it is ubiquitously expressed
+Reaches a maximum in mid-embryogenesis
+In late neurulae (stage 19), expression seen within the eye anlagen, with higher levels dorsally. At early tail bud stage (stage 25), expressed in each developing eye and in the heart primordia, located ventrally. In stage 26 embryos, the Tbx5-expressing cells of the heart primordia are seen to converge at the ventral midline, while expression also seen in two bilateral groups of cells continuous with and extending dorsally from the heart primordia. Expression in the dorsal region of the eye found to be maintained until early tadpole stages (stage 40), although expression becomes greatly restricted between stages 33 and 40. At stage 31/32, strong expression detected in the posterior region of the heart tube. After looping of the heart, a higher level of expression detected in the ventricle than in the atrium
+Expressed during G1, S and G2 phase of the cell cycle
+At 9.5 dpc, expressed predominantly in the heart, yolk sac mesodermal layer and endothelium, fetal vascular endothelium in the placenta, dorsal aorta, and ependymal layer of the neural tube. Expression that persists at 12.5 dpc, where expression is increased in some hemangioblasts in yolk sac blood islands, as well as more prominent expression in the ependymal layer of the neuroepithelium and in perineural blood vessels
+BPP-10a, BPP-10c+QQWA, BPP-13a, BPP-13+QWA and BPP-13A+QQWA seem to be found in both adult and newborn B.jararaca venoms
+Expressed during embryonic development from the mid-gastrula stage onwards
+In masseter expression decreases during development and becomes undetectable 3 weeks after birth
+Absent during G1 phase, accumulates during S, G2, and M phases, and disappears at the time of the metaphase-anaphase transition
+Expressed in third instar eye disks
+Expressed in embryos and at all larval stages
+First detected at 12 hours post-fertilization (hpf), increasing over the next 24 hours, then decreasing between 48 and 72 hours. Not detected in adult
+Detected in embryonic cell types, including germ cells (at protein level) (PubMed:21752937). In early third instar larvae, detected in the fat body (at protein level) (PubMed:29065309). Detected in the larval salivary glands and fat body (at protein level) (PubMed:21752937). Expressed in stage 17 embryos in male but not female gonads (PubMed:21752937)
+At 10.5 days of development it is expressed throughout the embryo. Later in development (12.5 to 14.5 days of gestation), expression is progressively up-regulated in neurons of the brain and the spinal cord, in all cranial sensory ganglia and in the sympathetic dorsal root ganglia
+Expressed from early embryogenesis to adulthood in various cell types
+Expressed both maternally and zygotically. Expressed during neurogenesis in neural plate primary neurons and in the anteroventral noradrenergic neurons. Expressed in the dorsal endoderm, throughout the gastrointestinal tract and in the ventral and dorsal pancreas from tail bud through tadpole stages
+At stage 14, expression occurs in each segment of the central nervous system. At stage 17, expression becomes restricted to the synaptic regions of the brain and ventral nerve cord, where synapses undergo maturation (PubMed:8999801). At 45 hours after puparium formation (apf) expression is enriched in the shaft of bristle cells in the sub-apical region. Present in all photoreceptors (PubMed:30290152)
+Expression is high in the midluteal phase corpus luteum and decreases during luteolysis
+Expressed in the developing limb buds
+Expression is low at 2 hpf and starts to increase steadily after 12 hpf to reach adult levels at 72 hpf
+From 14.0 dpc, expressed in developing myotomes. Once the muscle is innervated, localized to the neuromuscular junction (NMJ), where its expression is restricted to synaptic nuclei. Expression drops after birth
+During embryonic development, expressed in somites. First detected in stage 24 and remains excluded from the 2-3 caudal-most somites at all studied stages. First detectable in the developing hindbrain at stage 24. Expressed persists until stage 33. At stage 43, expressed in the olfactory bulb and thalamus
+Expressed maternally. Abundant in oocytes, with expression levels remaining constant during the blastula stage. Expression starts to decline during the gastrula stage and is barely detectable by the neurula stage
+Expressed from embryonic day 11.5 into adulthood
+Expression first detected at the pre-streak stage, uniformly distributed throughout the blastula. During primitive streak formation, expression localized to the anterior blastoderm including the anterior tip of primitive streak. At the beginning of Hensen node regression, strongly expressed, anterior to the node, in the ectoderm, in the presumptive neuroectoderm as well as in prechordal and lateral mesoderm. Later expression in the blastoderm anterior to Hensen node. During neurulation, high levels detected in the anterior neural plate. Expression also found in the neural folds including the pre-migratory cephalic neural crest cells, in the anterior ectoderm, in the lateral mesoderm, in the precordal plate and weaker expression in the notochord. From stage 10-14, strong expression in the anterior neural tube, including the optic vessels, where expression is limited to the presumptive neural retina and the overlying ectoderm. Later expression in the lens placode and the outer layer of the optic cup. Expression also in the prechordal plate, the Rathke pouch and later in the infundibular region. Expression in head mesenchyme, including migrating cephalic neural crest cells. Restricted expression within the metencephalic vesicle and ventral neural tube. Also expressed in the notochord, the otic vesicles, dorsal mesocardium and the area vasulosa. From stages 18-26, expression found in the telencephalic vesicles, in the epiphysis, in the optic cup, the trigeminal ganglia, and in a band which occupies the basal plate of prosomere one. During neural tube differentiation, expression follows a rosto-caudal gradient. Expression appears in the floor plate and in cells that occupy the medial neural tube. Expression also localized to the mesenchyme of the developing branchial arches, the most distal and ventral portion of the developing limb buds, including the ectodermal apical ridge and to the mesoderm of the developing kidney
+During embryonic development, prominently expressed in muscle tissues, including myocardium, skeletal and smooth muscles, and weakly in the developing central nervous system (only in the neuropil). At 9 dpc, expressed in the wall and trabeculae of the developing heart tube, in the caudal end of the midline dorsal aorta, and a focal area of the mesenchyme around the developing brain. Weakly expressed in marginal and ependymal layers of the early neural tube. At 11-12.5 dpc, expression persists in the myocardium. Scattered signal in the mesoderm on either side of the developing neural tube. Also found in the region of dermatomyotomes. Appears to be associated with the early pre-muscle mesoderm and later with myoblasts and myocytes of the paravertebral, back, body wall and limb muscles. At 13-15 dpc, besides the myocardium, expression is seen in the skeletal muscles of the limbs, intercostal muscles, and the diaphragm, as well as in the developing muscle layer in the wall of the few intestinal coils present in the abdominal cavity. Also found in various components of the mesenchymal precartilage forming the framework of the cranium and the face, notably, the base of the skull, frontonasal process and parts of the primitive maxillary and mandibular processes. Around 13 dpc, detected in the brain lateral ventricles and the roof of the fourth ventricle. At 15 dpc, scattered groups of positive cells are observed in the liver, around the venous sinuses. Weakly expressed in the brain and spinal cord white matter. Prominent membrane expression in the choroid plexus and meninges. At 15-18 dpc, transiently expressed in the layers of ectodermal cells covering the embryo and in immature cells of the lung buds. From 16 dpc to postnatal day 2, no change in the basic pattern of expression (at protein level)
+At 1 day post fertilization (dpf), expressed ubiquitously in developing eyes, brain, heart and skeletal muscles. Maternally expressed up to 8 hour post fertilization and zygotic expression starts at 1 dpf and continues until 5 dpf
+Expression in kidney is highly induced 3 days after birth
+This protein is specifically expressed in the embryo, being more abundant in the early cleavage stages
+Expressed both maternally and zygotically. Abundant in the animal hemisphere of the blastula embryo and during early embryogenesis. Expressed in ectodermal and mesodermal cell lineages where expression becomes spatially restricted to the developing nervous system as development progresses (at protein level). Expressed in the neural plate at late neurula stage (stage 17). At early tailbud stage (stage 25), expression continues in the neural tube and begins in the eyes. At late tailbud stages (stage 30), expressed broadly in the CNS (PubMed:7542467, PubMed:18241856)
+Present in both the somatic and germline
+Detected at all developmental stages. The extremely high level of transcription detected in the early embryo and in adults is caused by maternal message
+Expressed (at protein levels). Up-regulated upon starvation, reaching a maximum around 10 hours. Expression subsequently declined but is present throughout development
+Absent from liver after birth, but increases around postnatal day 16
+Produced in encysting cells
+Expressed in fetal liver and aorta
+Expression drops sharply between 4 and 8 hours of development and reaches a very low level at 24 hours
+Expressed in the cytoplasm of anterior lens epithelial cells, expression becomes predominantly membranous as lens fiber cell differentiation progresses at 3 weeks of age
+Germ cell-specific, but may also be expressed in cells that require the presence of germ cells. Cranial to caudal punctate expression is seen in the developing ovary starting at 13.5 dpc. At 13.5 dpc. expressed in the cranial part of the XX gonad. At 14.5 dpc, expression extends to almost two-thirds of the XX gonad, and by 15.5 dpc expression is seen throughout the entire organ. By 16.5 dpc, expression is only detected in the most caudal tip of the XX gonad. Expression switches from the embryonic ovary to the postnatal testis
+Accumulates to a high level at the beginning of the ecdysone response, during the metamorphosis of imaginal disks in puff stage 1, and abruptly disappears after several hours
+Low levels in 0-8 hours embryos and adults. Higher in late embryogenesis and during larval and pupal stages. Short isoform is enriched in pupae and adults, long isoform in larvae
+Maternally expressed. Expressed at low levels throughout the embryo up to 24 hours post-fertilization (hpf)
+Age-dependent accumulation. First observed in young seedlings in cotyledons and regularly in the tip regions of very young leaves. Accumulates strongly in older leaf parts at the senescence onset. In flowers, present in mature organs such as old sepals, petals, old stamens, mature anthers, and pollen grains. Confined to floral organ abscission zone of mature flowers. Also observed in roots
+At stages 16 and 32, expressed in the neural groove, rhombomeres, forebrain and branchial arches
+Expressed in a meiosis-specific manner
+Found at all stages of development. Down-regulated at the onset of aggregation, but small amounts are still detectable at late stages of development (at protein level)
+Expressed during the asexual blood stage including in trophozoites (at protein level)
+First seen during the formation of neural keel. At 9-10 hours of development expression seen in two laterally located transverse stripes of cells in the rostral 1/3 of the embryo, and the two areas subsequently move towards the midline and form the posterior portion of the midbrain. Detected in the otic placode, Wolffian duct including the nephritic primordium and optic stalk at 10-12 hours. At 14-15 hours expression seen in the single cells along the spinal cord, presumably interneurons
+Levels decline with increasing age
+In neonatal animals, highly expressed in skin where it localizes to a region of the inner root sheath of hair follicles (at protein level) (PubMed:12370446, PubMed:16920948). Also expressed in thymic medullary epithelial cells (at protein level) (PubMed:12370446, PubMed:16920948). Detected in skeletal muscle, eyes, and submandibular glands (PubMed:12370446)
+Low expression from cleavage stages to the end of gastrulation; increases from neurulation onward. During neurulation, first localized to the anterior neural folds. As neurulation proceeds, the expression extends to the trunk neural fold, with low levels in the posterior neural fold. At the end of neurulation, strongly expressed as a large band in the midbrain. After neural tube closure, also detected in the optic lobes and otic vesicles. During the late development, expression remains restricted to the nervous system. Detected until at least the larval stages
+Expressed throughout development (PubMed:10993680). Highly expressed in hyp10 tail tip cells in early L4 larval stage males (PubMed:21408209). Expressed in hyp10 tail tip cells prior to and during male tail tip retraction (PubMed:21408209)
+Expression is highest during early embryogenesis and slightly decreases over time
+Expressed at 9.5 dpc embryos in the notochord, spinal cord and the epithelium of the fore- and midgut, including in the developing dorsal pancreatic bud (at protein level) (PubMed:10471502). Expressed at 10.5 dpc in both the dorsal and ventral pancreatic buds, declining by 12.5 dpc, but increasing again by 13.5 dpc, and by 17.5 dpc expression becomes restricted to the developing islets of Langerhans (at protein level) (PubMed:10471502). Expressed at 11.5 dpc and 12.5 dpc in developing spinal cord, especially in motor neurons (at protein level) (PubMed:18539116)
+Highly expressed in the insect stage (Promastigote)
+Expressed at equal levels in 19-23 weeks old fetal tissues
+In the M1 pharyngeal neuron, expressed in all larval stages and in adults. In the M2 pharyngeal neuron, expression is not detected in most L1-L3 larva but increases at the L4 larval stage
+First expressed at 8.0 dpc. During neural tube closure (8.5 dpc), expression appears for the first time in the rhombencephalon in the presumptive region of future rhombomere 4. During neurogenesis (9.5 dpc to 10.5 dpc), predominantly expressed along the anteroposterior axis of the CNS in the mesencephalon, metencephalon and rhombencephalon. Expression is strong in the tectum of the mesencephalon and in the hindbrain, expression is restricted to rhombomeres. Expression in the spinal cord is weak and confined to the alar plate. Beginning at 9.5 dpc, expressed in the epithelial component of the branchial arches and foregut. At 10.5 dpc, expression extends rostrally into the dorsal diencephalon. Starting at the otic vesicle stage, shows regionalized expression in the developing inner ear with expression in the entire otic vesicle from 10.5 dpc onwards. From 10.5 dpc onwards, weak expression begins in the limb bud. Also expressed in other tissues during organogenesis; at 9.5 dpc, expressed in the superficial ectoderm surrounding the body and in the region of the foregut, which will form the pharynx and the lung bud. at 10.5 dpc, found in the cephalic mesenchyme around the optic vesicle. By 12.5 dpc, still expressed in the mesenchyme, and expression begins in specific subsets of post-mitotic cells in the neuroretina. As development ensues, expression increases in the neuroretina and mesenchymal expression gradually decreases. At 16.5 dpc, expressed exclusively in the inner neuroblast layers of the neuroretina. Expressed in the developing heart in the ventricular septum from the onset of its formation (10.5 dpc) onward. In fetal stages, expression becomes confined to the myocardium of the atrioventricular bundle and bundle branches of the forming ventricular conduction system
+Expressed both maternally and zygotically. Highly expressed in preblastoderm-stage embryos. During the later stages of embryogenesis, expression is ubiquitous with the level progressively decreasing
+Weakly expressed in the heart tube at 30 hours post-fertilization (PubMed:23836893). Expressed at as early as epiboly stage, and is broadly distributed till early segmentation stage and in developing retina and skeletal muscle. In the eye, expression is detected in the optic primordium at the 6-somite stage and is steadily expressed during the invagination of the optic vesicle from its initiation to its expansion to the lens rudiment. In skeletal muscle, a faint signal is detected in muscle precursor cells at the early segmentation period, and in ventral somites from the 21-somite to 24 hour post fertilization stage. Expression decreases sharply during 36 to 48 hour post fertilization stage while it reaches its highest level at about 72 hour post fertilization stage. During this period, the distribution extends to the dorsal somites. In addition also appeared in the brain and neural crest cell (PubMed:20532172)
+Ubiquitously expressed in early development. Expressed in the time window of embryonic stem (ES) cell differentiation
+Observed at early stages of flowers and fruits development (PubMed:23398891). Expressed in flowers and drupes at 10 weeks after pollination, and, at low levels, in fruits at 15 weeks of ripening (PubMed:23398891)
+Expressed at higher levels in actively dividing cells
+At the embryonic day 8.0 dpc, expressed at the node, especially in pit cells, which are located at the central region of the node and possess motile cilia. At later stages, expression is detected in the notochord at 9.0 dpc, in the hindbrain, the branchial arches and neural tube at 11.0 dpc, in the hindbrain at 12.0 dpc and in the forebrain at 13.0 dpc
+Detected in isolated elementary bodies 40 hours post-infection (at protein level)
+Expressed prominently during both female and male gametes development (PubMed:11058164). Accumulates throughout young developing leaves, before being confined to the vasculature of older leaves (PubMed:19837869)
+Detected in the floral meristem and primordia of floral organs. During early stages of flower development, expressed in the whole floral meristem, especially in emerging primordia. Later present in developing carpels, particularly in emerging ovule primordia. After fertilization, observed in the embryo and the chalazal endosperm. High levels at the early embryogenesis stages that fade out later. Also present in the developing seed coat, the septum, and the silique wall. In the stamens, detected at high levels in the anthers. Observed in sporogenous cells and then in tetrads of microspores
+High levels during embryogenesis, moderate levels during L1, L4 and adult stages and very low levels during L2 and L3 stages
+Detected in seedlings 6 hours post-germination, but not 2 days post-germination
+Expression was first clearly detected as early as 8.5 dpc specifically in heart and is regulated temporally and spatially in the myocardium. Transcripts are present in uniformly high levels in the myocardium. Throughout cardiac development, expression is specific for the myocardium; endocardial cushions and valves exhibit only background levels of signal. Transcript levels persist but gradually decrease in neonatal, 2-week-old, and adult hearts
+Maternal protein which is distributed within an animal-to-vegetal gradient in the embryo. Present throughout the entire development
+Expressed in siliques from 0 to 10 days after fertilization (DAF). Levels decrease at 13 DAF and disappear at 16 DAF. Expressed early in seed germination from 6 hours to 48 hours after seed imbibition
+Maximally expressed just before cell cycle start
+Detected as early as 1 hour post-fertilization (hpf). Primarily localized in the head at 48 hpf
+Expressed in developing seeds from 5 to 30 days after flowering (DAF)
+Expressed in the presumptive midbrain of developing embryos from the six-somite stage. By 24 hours, strongly expressed in the midbrain caudal to the presumptive tectum. At later stages, maintained at the posterior margin of the tectum
+Detectable at 24 hpf and gradually increases through development. Detected in the nervous system in olfactory placode, olfactory bulb, telencephalon and tectum
+Expressed from the beginning of embryogenesis and during gastrula stages with widespread expression during early gastrulation (PubMed:11493557, PubMed:11566855). As epiboly continues, a shallow dorsoventral gradient begins to appear around the embryonic shield stage at 5-6 hours post-fertilization (hpf) with higher levels seen in the future organizer region (PubMed:11493557). At the tail bud stage, expression is down-regulated in the non-neural ectoderm and is found only in the neural plate and axial mesoderm with higher levels seen in the future head and tail domains (PubMed:11493557). As somitogenesis proceeds, the expression domain on the dorsal side expands laterally to adaxial mesoderm and somites (PubMed:11493557). At 26 hpf, high levels of expression are found in the ventral diencephalon, epiphysis, tectum and pectoral fin buds (PubMed:11493557). Expressed at higher levels in the head than the rest of the body at the 18-somite stage and at 24 hpf (PubMed:11566855). By 2 days post-fertilization (dpf), expression in the head is confined to dorsal brain nuclei and jaw cartilages and expression is also seen in the pectoral fin (PubMed:11566855). Also expressed in cells of the caudal fin primordium during development (PubMed:17597528)
+Low level during G1 and S phases. Peaks at M phase. During anaphase, it is degraded
+At stage 9.5 dpc ubiquitously expressed, at 12.5 dpc expressed in structures of the CNS, especially in zones of the proliferative active ventricular zones of the brain and in the spinal cord. Expression increased in organs that were in the state of organ expansion like lung and liver. At 17.5 dpc, expression was strongly reduced in endoderm-derived tissues. In early postnatal development, strongly expressed in regions of ossification
+During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells. In embryonic muscle, ENO1 is highly expressed until 17 dpc. Decreased levels from P5
+Isoform D and isoform sro are expressed both maternally and zygotically. Zygotic expression is present throughout embryogenesis, fading by second larval instar. Isoform D has higher expression level than isoform sro
+Embryonic. The protein is first detected in early blastula stages, its level peaks in late cleavage, declines abruptly before ingression of primary mesenchyme cells and remains constant in late development
+First expressed in embryos at the 100-cell stage (PubMed:16701625). First expressed in pharyngeal precursors at the 100-200 cell stage and expression continues in the pharynx until near hatching, when expression becomes restricted to several neurons in the head (PubMed:23933492, PubMed:25873636). In larval stages, expressed in head neurons and occasionally tail neurons (PubMed:23933492). In L4 larvae, expressed in the gut and seam cells (PubMed:23933492). In larval stages, not expressed in the pharynx (PubMed:23933492)
+Expressed in neurons and intestinal cells in L2 stage larvae
+Appears first in the multicellular stage soon after tip formation and is selectively expressed on prespore cells
+Between 10 and 30 days after pollination
+Expressed during the parasite blood stage, including in rings, trophozoites, schizonts and merozoites (at protein level)
+Levels increase in the iris from embryonic day 9 (9 dpc) to 16 dpc and in the choroid, levels are high from 9 dpc to 14 dpc but drop at 16 dpc
+Barely detectable in at 6 weeks and is highly expressed in adipocytes of visceral white adipose tissues at 30 weeks
+During the pre-organogenesis stage of the floral primordium, expressed in scattered islands of cells in the central parenchymatous pith region and in the peripheral ground parenchyma. Upon sepal buttresses emergence, expressed in all parenchyma mesophyll cells accumulating in a continous pattern in the central pith cells of the floral primordia, but not expressed in the future epidermal cells. As the mesophyll and vascular tissues elongate and differentiate, highly expressed in the abaxial mesophyll cells of sepals, but down-regulated in the adaxial cell layers. At anthesis, down-regulated expression in all mesophyll cells of the sepal. In petals, expressed in all mesophyll cells throughout development
+Late stages of sporulation, during ascospore wall formation. Probably functions before partitioning of nuclei or is distributed to developing ascospores prior to the completion of pro-spore walls
+Expressed in developing caryopses from 1 to 7 days after flowering (DAF) and then declines to nearly undetectable levels by 10 DAF
+Expression in nodules increased with increasing plant age up to 21 days, then decreased
+Expressed throughout development; expression levels drop immediately after birth. Strongly expressed throughout the primitive nervous system, the hepatic primoridium and the earliest limb buds
+Expressed maternally. Expression levels decrease from gastrulation until the onset of neurulation (stage 15), when expression is absent
+At the onset of gastrulation, expressed within the marginal zone and in the dorsal animal hemisphere. In advanced gastrulae (stage 13), detected in the prospective neuroectoderm and the underlying involuted mesoderm, in an area that corresponds to the prechordal plate. At stage 14, expressed in the cement gland anlage, the mid-/hindbrain boundary and the auditory placodes. At tadpole stages of development, most prominent in the first, second and third branchial arch, in the lens epithelium and in the posterior dorsal fin, as well as in the posterior wall of the tail tip
+Expressed both maternally and zygotically. Expressed in the dorsal midline during gastrulation and neurulation. Expression is strong in the prospective ventral forebrain region of the anterior neural plate
+Expression is detected at day 15 after birth and gradually increases from day 15 to 5 months. Expression is found in round spermatids with little expression in spermatogonia
+Detected throughout the Wolffian duct epithelium from 9.5 dpc to 14.5 dpc. Detected in the stalk region of the ureteric bud at 10.5 to 11.0 dpc. Continues to be expressed in the developing collecting duct system throughout nephrogenesis, but is not detected at branching tips. Within the urogenital tract, expression is restricted to the kidney at 15.5 dpc (PubMed:16054034). Detected in embryonic head from early headfold stages to at least 12 dpc
+Expressed from 43-day and 54-day embryonic eye development
+Expressed from 1 to 3 days after seed imbibition (PubMed:10805817). Expressed from 1 to 5 days after seed imbibition (at protein level)
+Detected during gynoecium development
+Expressed both maternally and zygotically. Expressed at the cleavage stage, with expression disappearing at the gastrula stage
+Expressed in embryo, larva and adult
+Weakly or not expressed from 12 dpc to 20 dpc. Expressed at much higher level from postnatal day 2, reaching a maximum level in adult brain
+First expressed at embryonic stage 9, with expression increasing at neurula stage and again at the tailbud stage. Expression persists through development to adulthood
+In testis: weakly expressed in newborns, increases remarkably at 3 weeks postpartum, and peaks at 2 months postpartum (at protein level)
+First observed in nuclei of epidermal cells 16 hours post germination (PubMed:19523675). Later confined to cells undergoing asymmetric divisions (e.g. stomatal lineage cells) (PubMed:19523675). Expressed in protodermal cells in young seedlings (PubMed:30429609). Copolarizes with YDA and MPK3/MPK6 in stomatal asymmetric cell division (ACD) cells (PubMed:27746029)
+Expressed from the embryonic stage of development to adulthood
+Expressed both maternally and zygotically. Zygotic expression peaks at embryonic stages 8-16
+Expressed in developing caryopses from 1 to 5 days after flowering (DAF) and then declines to nearly undetectable levels by 10 DAF
+Detected in the theca layer of the ovarian follicle in the white follicle (WF), F1, F3, F5, and postovulatory follicle stages. In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens
+Not detected in seedlings 6 hours or 2 days post-germination
+In testis expressed from day 21 during postnatal development (PubMed:24013621). In the epidydimis, first detected at day 28 and high expression is maintained until day 35. Thereafter, level declines gradually (PubMed:24013621)
+Expressed throughout the development. Expressed in embryos, L1, L2, L3 and L4 larval stages and in adults
+Expression begins about halfway through embryogenesis. Expressed at higher level in late embryos and in L1 larvae, and fades thereafter. In adults, a weak expression is maintained in several neurons, including ASH but not AWC
+In roots, observed in all tissues with highest levels in the vascular cylinder, the meristematic zone of the primary root tissue, and lateral root (LR) primordia
+Expression peaks between 11 dpc and 17 dpc, and decreases from P0 to P28. Expressed in lung throughout embryonic development. At 12 dpc, expressed in spinal cord, dorsal root ganglia and sciatic nerve. At 15 dpc, highly expressed in all neural tissues. At P0, expressed in brain and spinal cord. Present in Schwann cells at 16 dpc and P0 (at protein level). Maternal product is present in preimplantation embryos. Expressed in pluripotent embryonic stem cells. Down-regulated when embryonic stem cells differentiate
+Strongly expressed upon gastrulation and subsequently becomes restricted to skeletal muscle and subregions of the CNS. At 9.5 dpc, expressed in the branchial arches, somites and gut but little in the heart and neural tissues. At 12.5 dpc strongly expressed in the cranial skeleton, tongue, vertebral cartilage, pituitary and the luminal epithelium
+Expression levels increase during the first 4 weeks after birth and remain constant during the following 3 weeks
+Major encystment-specific protein
+During parasite asexual blood stages, expressed in trophozoites and at the schizont stage (at protein level)
+During early embryogenesis, not expressed in unfertilized oocytes or fertilized one-cell embryos but detected in blastocysts
+Expressed during embryonic development. At Carnegie stage 22 (about 7.5 weeks gestation), expressed in numerous tissues, including brain, heart, lung, gastrointestinal tract, kidney, hind limb and forelimb digits. Similar expression is observed at 9 weeks of gestation. In the brain of a 9-week old fetus, prominently expressed in the neocortex subventricular zone and in the cortical plate and also detected in the ganglionic eminences. At 12 weeks of gestation, expression in the fetal brain is prominent in the basal ganglia and the ventricular and subventricular zones and cortical plate of the neocortex, mesencephalon, and rhombencephalon. At 15 and 16 weeks, highly expressed in the ventricular and subventricular zones, respectively. Highly expressed in the ganglionic eminence of 15 week-old brain and subplate of 16 week-old brain. At 20 weeks of gestation, expressed in the ventricular and subventricular zones, intermediate zone, and cortical plate of the neocortex. At 21 weeks of gestation, expressed in the neocortex with highest levels in the cortical plate
+Expressed during sporulation; strong expression 60-150 minutes after sporulation onset, falls to background expression by 240 minutes. Found only in mother cells
+Rare transcripts expressed in cotyledon and roots during the development
+Detected at very low levels 48 hours before adult emergence. Levels dramatically increase around 24 hours prior to emergence and are subsequently maintained at a similar level in both newly emerged animals as well as in animals 24 hours postemergence
+Mostly expressed in old stems (PubMed:8819324). In flowers, higher levels in unpigmented corolla tubes than in pigmented limbs (PubMed:8819324)
+Expressed from the comma stage of embryogenesis, during all larval stages, and in low levels in adults (PubMed:9685599, PubMed:15236235). Expressed in the ALA neuron in L4 stage larvae (PubMed:27546573)
+Actively produced during the active phase of tuberculosis
+Expression overlaps with the one of SHH and IHH being restricted to tissues that require Hh signaling. PubMed:12372301, reported a more ubiquitous expression which is detected throughout the embryo at 7.5 dpc and is maintained during embryonic development
+Expressed in blastoderm embryos in two ventrolateral stripes that are brought to the midline as gastrulation proceeds. In the germ-band retraction stage, expression is seen in the CNS and epidermis. At late blastoderm, expression is localized in the anlagen of the amnioserosa. Expression in the head, cypeolabrum, maxillary and labial lobes, and around the stomodeum throughout embryo development. In late embryos, expression decays in all ectodermal cells and appears in the segmental muscles and the gut wall. In the larva, expression occurs in the dorsal metathoracic disc, the eye-antennal disc and the ventral thoracic disc. Found in the intervein in the pupa
+Oogenesis and embryogenesis
+Detected at low levels in newborns. Levels increase strongly and are highest in hippocampus from 8 to 14 day old animals. Detected at intermediate levels at day 42 (at protein level)
+In brain, expression reaches maximum levels at day 12 of the embryonic stage. Keeps almost similar levels during mouse development
+Found in the mitochondria from unembryonated eggs, and in second-, third-, and fourth-stage larvae. Highest expression found in second-stage larvae. Reaches undetectable levels in the adult
+Active complex is found in G1, S and G2 phases
+Accumulates transiently in germinating seeds (at protein level) with a constant transcript level (PubMed:17283014). Abundant in cotyledons (mostly in senescing cotyledons) during post-germinative growth and in sink tissues, such as young leaves, developing flowers, siliques and seeds (at protein level) (PubMed:17283014, PubMed:19807880). In flowers, present in the nectaries, stigma, endocarp of the fruit wall and in tissues involved in the transfer of assimilates to the developing ovules and seeds, such as the vasculature and seed coat (at protein level) (PubMed:17283014)
+Concentrated in meiotic and postmeiotic spermatogenic cells
+Mostly expressed in both apical and basal regions in peduncles and stems (including upper roots) before the bolting stage. Later restricted in the apical region. During embryogenesis, accumulates in all cells during globular stage. From the heart stage, more expressed in inner cells than in epidermal cells (at protein level)
+Increases with flower development, especially during nectary development, but decreases abruptly with the opening of the flower
+Expressed during exponential growth and shut down at the entry into stationary phase
+Is expressed at low levels during gestation. Just before birth the level increases dramatically and remains stable afterwards
+Preferentially expressed in Plasmodium
+Expression increases during floral development. Expressed during ovary development with the highest expression on the third day after the flower fully opened
+Expression enhanced late after interaction of IL-2 with its receptor, approximately when cells enter S phase
+Expressed in tadpoles from premetamorphic stage 53 until the end of prometamorphic stage 60. Expression levels reach a maximum at prometamorphic stages 58 to 59, then decline gradually during metamorphic climax stages (61-66). Undetectable in adults
+Detected throughout development, starting with the pre-implantation embryo
+Expression increases in the maturing panicle, but is low in developing seed
+Highest expression during the exponential growth phase
+Expressed in all stages of zygotic development, with highest levels of expression during embryonic and early pupal stages, and lower levels in larval and adult stages
+Maternally expressed in the early blastomere. Expressed in the involuting mesodermal cells and ectodermal cells of early gastrula stage embryos. Expression increases from stage 10.5, when the gastrulation movement occurs. Expression is concentrated at blastopore lips and the dorsal site of stage 11 embryos. Present in head structures and the trunk at the neurula and tailbud stages
+Widely expressed during embryonic development. Prominent in the matrix of the leptomeningeal anlage, in basement membranes of the neuroepithelium and the perineurium of peripheral nerves. In embryos of gestational week (gw) 4, staining was observed in the early mesenchymal bone anlagen. In gw 6.5 and 8, all perichondrial structures showed expression but the chondrocytes themselves showed no staining. In gw 10, expression is prominent in the interterritorial matrix surrounding the hypertrophic chondrocytes
+Strongly expressed in pollen grains and pollen tubes
+Expression in the brain decreases with age as detected from 17 dpc to 12 months
+Expressed in gonads from 11.5 dpc onward. Expressed in the genital ridge at 11.5 dpc and in the seminiferous tubules at 12.5 dpc
+Expressed in the third larval instar and maintained through to early pupal development
+In oocytes, expression is lowest in ovarian follicles at stages I and II but gradually increases after the onset of vitellogenic growth, peaking at vitellogenic stages (stage IIIB)
+Expressed at highest levels during the G0-G1 transition in the cell cycle of mesophyll protoplasts
+Expressed in the differentiating tissues during early embryogenesis
+Expressed maternally. The protein accumulates during the first 3 hours after fertilization, and then decreases rapidly
+In the embryo, expression is detected just before hatching
+During root development, expressed in the meristems, in part of the elongation zone, in which cells divide and expand, and initiation sites of lateral roots (PubMed:9843485). In mature embryos from dry seeds, observed in the zone corresponding to the root apical meristem and in cotyledons (PubMed:9843485)
+Highest levels in embryos and adults, lowest levels in larvae. Maternal expression results in high zygotic levels
+Decreases slightly during the first hour of the cell cycle then increases to maximal levels by 2 hours, at the protein level
+Specifically expressed during the reproductive developmental stage. Expressed in embryonic shoot apical meristems, in inflorescence and floral meristems, and in developing stamens, carpels and ovules
+Expressed consistently in both vegetative and developing cells
+Expressed at high levels in the developing brain, reaching a peak at 17.5 dpc, followed by a decrease at 19.5 dpc. Highly expressed during the postnatal period. Expressed in cortical neural precursor cells at 17.5 dpc
+Expressed during embryonic development starting from 7 dpc. Expression increases moderately during embryonic development and remains stable in the postnatal brain
+Expressed in hypocotyls and roots upon germination. As seedlings mature, detected in the vascular tissue of both the stem and leaf
+Expressed in 5 to 8 days after pollination endosperm and does not change significantly during later developmental stages
+In embryos of gestational week (gw) 24, detected mostly in the epithelial cells of saccular surfaces. In gw 39, detected in the cells lining the alveolar surfaces as well as in the mesenchyme (at protein level)
+Isoform 1 and isoform 2 are expressed in spinal cord, medulla, pons, tegmentum, thalamus and hypothalamus at 15 dpc onwards (PubMed:7472412, PubMed:7472413, PubMed:9891978). In the brain cortex and in the hippocampus, strongly expressed during periods of synapse/spine reorganization at postnatal day 8 (P8) to P15. Expression declines after P25 (at protein level) (PubMed:24297929)
+First expressed during the late gastrulation stage of embryogenesis with high expression in the tail region (PubMed:25448694). In the comma stage of embryogenesis, expression is prominent in the body wall muscle cells (PubMed:25448694). In early larval development, expressed in hypodermal cells, muscle, the pharynx, intestine and in anal depressor and stomatointestinal muscle (PubMed:25448694). In the nervous system, transiently expressed in late embryogenesis and early larval development in AVG unpaired interneurons and during larval development, expressed in neurons in the head and tail ganglia and ventral cord motor neurons (PubMed:24401370, PubMed:25448694). In the late stages of larval development, expressed in the distal tip cell, the vulva, uterine muscle cells and the VC4 and VC5 neurons that flank the vulva (PubMed:25448694)
+Expressed in tissues with active division, with the highest levels in 3-week-old leaves and lowest levels in senescent leaves
+Rises dramatically in the late third instar, then decreases gradually during the pupal stages. Low expression is found in adults
+Very strong staining is detected in the Purkinje cell layer and in part of the molecular layer of the infant brain compared to adult brain
+Highest at day 7 of embryonic development after which it declines to its lowest levels at day 11 before increasing again
+Detected in vegetatively growing cells (at protein level)
+Expressed during the maturation phase of stomatal guard cells but not in fully mature stomata. In the root vasculature, detected soon after germination, with a maxima around the lateral root primordia
+Throughout oogenesis expressed in the germline and associated somatic cells (at protein level) (PubMed:25236597). In germline cells of the germarium, expression levels peak during follicle formation and again from mid-oogenesis until late oogenesis (at protein level). Expressed both maternally and zygotically (PubMed:15579689). Expression peaks in 12-18 hour embryos, and continues at a constant low level of expression through to adults (PubMed:15579689)
+Expression peaks at mid- to late-stages of development
+First detected in the testis 18 days after birth. Levels increase successively between days 21-28. On day 42, levels decrease
+Expressed in the outer layers of globular embryos
+Detected in 12-, 14-, and 17-day-old mouse embryos in the posterior half of the myelencephalon, spinal cord, dorsal root ganglia, first cervical vertebra, thyroid gland, kidney tubules, esophagus, stomach, and intestines
+Expressed throughout embryogenesis mainly in dividing cells
+In the 7-week-old, expressed in spermatogenic cells at every stage, (spermatogonium, primary spermatocyte, spermatid, and mature sperm). Expression levels increased during spermatogenesis. No expression in Leydig cells
+Strongly up-regulated from 7 dpc to 11 dpc. Widely expressed at 8.5 dpc. At 11.75 dpc, expression is strongest in developing neuroepithelium and eye
+Expressed in the organ of Corti in the inner hair cells (IHCs), but not in the outer hair cells (OHCs) at 16 dpc. Expressed strongly in the IHCs and faintly in the OHCs at 18 dpc (at protein level)
+Expressed in germinating seeds prior to protrusion of the radicle, especially in the vascular bundle of the seminal root 3 days after sowing
+Expression gradually increases with time under both long-day (LD) and short-day (SD) photoperiods. Under LD conditions, expression is first detected on day 4 and plateaued around day 6, preceeding floral commitment around days 9 and 10
+Detected both in virgin mouse and after mammary gland involution. The level of STAT5A increases constantly during pregnancy, but decreases during lactation
+In the developing embryo, a high level of expression is confined to the nervous system particularly in the dorsal root ganglia, cranial nerves, and neural retina. From 10.5 dpc, expressed at low levels in the basal plate along the entire neural tube, while at 12.5 dpc the expression in the nervous system is definitively stronger, especially in the cranial and dorsal root ganglia and in the spinal nerves. In the hypothalamus, the expression is confined to the retro-chiasmatic area (RCH) and is also detectable in the remnant of the Rathke's pouch. In the developing eye, exclusively expressed in the prospective neural retina, equally distributed in both the deep and superficial layers. At 16.5 dpc, expression is still detectable in the outer neuroblast layer of the neural retina
+Down-regulated during leaf senescence
+Expressed after birth, reaching a maximum at postnatal day 14 in the cerebrum and postnatal day 3 in the cerebellum. Then, it decreases abruptly thereafter (at protein level)
+Isoform C, isoform E and isoform F have very similar expression patterns during embryonic and larval stages, suggesting coexpression in the same tissues
+Actin-1 is formed in all parasitic stages; asexual blood stages and in the sexual stages. Actin-2 is stage-specific, formed only in the sexual stages of the parasite's life cycle
+Expression is up-regulated during gastrulation
+Expression is low in unfertilized eggs and early embryos, increases in older embryos and young larvae, is low in mature larvae and increases strongly in pupae and adult flies. Expression during embryogenesis is restricted to the central nervous system (CNS) and the Garland cells, a small group of nephrocytes that takes up waste materials from the hemolymph by endocytosis. In post embryonic stages, expression is seen in the larval salivary glands and the CNS, and in the adult CNS and reproductive systems
+Highest expression at 18.5 dpc, followed by a gradual decrease
+At 15.5 dpc, highly expressed in brain, lung, adrenal, thymus and kidney. Expression was also seen in spinal cord, retina and snout
+Up-regulated during the differentiation of bone marrow precursors into macrophages
+Detected at 7.5 dpc in neuroectodermal cells, and later in neural crest, in ventral region of the spinal cord and in ventricular epithelium of the neural tube
+Up-regulated during cellular differentiation
+Not detected in vegetative cells. Up-regulated during cyst cell formation
+Expression is very low in the prepubertal testis (2-5-, 8- and 17-day-old) but becomes abruptly induced in the postpubertal testis (29-day-old), after which expression increased (35- and 60-day-old)
+The highest expression is found in 6-d embryos, is reduced to 30% before hatching and remains stable thereafter
+Isoform 1 is expressed throughout the cell cycle. Isoform 2 is expressed following mitosis and peaks in the G1/S phase of the cell cycle
+In young seedlings, expressed in the shoot apical meristem (SAM) and in root tips (PubMed:22897245). In inflorescence, highly observed in the pistil and in seeds, but weakly present during male gametogenesis (PubMed:22897245). Observed at very weak levels from the late bicellular pollen stage to the mature pollen stage (PubMed:22897245). Detected in the germinating pollen tubes (PubMed:22897245)
+Expressed in the floor of the diencephalon at 10 dpc (at protein level). Expressed in the midline of the forebrain and in the eye region at 9 dpc. Expressed in the head ectoderm destined to become the lens vesicle at 9 and 10 dpc. Expressed in the lens placode at 10.5 dpc. Expressed in the lens vesicle in both epithelial and fiber cells at 11 dpc. Expressed in secondary fiber cells at the equatorial region that divides the lens into anterior and posterior hemispheres between 11 and 14 dpc. Expressed in the neural tube and in primary fiber cells of the lens at 11.5 dpc. Expressed in proximal tubules of the cortex in the kidney at 16 and 17 dpc. Expressed in hypertrophic chondrocytes at 14.5 to 18.5 dpc. Expressed in the pancreas at 12.5 dpc until the adult stage
+Transiently expressed in the root tip during seed germination up to about 21 hours after stratification
+In flowers, at 22 degrees Celsius, preferentially expressed in the stigma in the pistil, but expands to the transmitting tract, along which pollen tubes elongated, upon temperature shift to 30 degrees Celsius (PubMed:23910659). Expressed in roots developing protophloem, up to the end of the transition zone (PubMed:23569225)
+Expressed at L4 larval stage and to a lesser extent in adults
+Expressed in 1 to 3 week-old fruit but not in mature fruit. Expression is tightly associated with cell division
+Expressed both maternally and zygotically after the midblastula transition. Present both dorsally and ventrally at the beginning of neurulation. Expression is restricted to the developing heart at the tailbud stage
+Expressed maternally in the oocyte (at protein level)
+Expressed in the yeast phase during infection, and not in mycelia
+Detected first in bicellular pollen and then most abundant in tricellular and mature pollen and growing pollen tubes
+Expressed in epidermis and wing disks, and at a lower level in midgut, on day 2 of the wandering stage (W2) larvae (PubMed:15898116). In wing disks, expression increases from W2, peaking on day 3 of the wandering stage (W3) and decreasing thereafter. In fat body, expression peaks sharply at W3 and then decreases. In midgut, shows a sharp peak on the day of pupation (P0). In silk glands, low expression peaking at W3. In hemocytes, expression peaks at W3. Overall low expression level in all the organs examined (PubMed:28943345)
+Higher expression in fetus than in adult
+Expressed in joints of immature siliques, decreases with maturation and not detected in the joints of mature siliques
+Expressed in embryo at 13 dpc onwards. Expressed in embryonic heart at all stages of development
+Expressed in the retina from 16.5 dpc to P1, in the thymus from 18.5 dpc to P1, and in kidney from 16.5 dpc to 18.5 dpc
+Expressed both maternally and zygotically. Expressed at lower levels in larvae and adult
+Restricted to spermiogenesis, starting at the pachytene spermatocyte level and peaking at the round and elongating spermatid stage
+During embryogenesis, expressed in the embryo from octant to heart stage
+Specifically expressed in cells differentiation from the PS point, a specific point from which cells enter the differentiation phase in response to starvation. Not present in the exponentially growing cells, starts to accumulate within 2 hours following removal of growth medium, reaching a peak at 4 hours then disappearing
+At the initiation time of the stomium degeneration program, expressed in all floral organs. Later, transcripts levels increase in pistil, petal, stamen filament, and in vascular region close to the stamen filament. When the anther dehiscence is initiated, levels of transcripts decrease, except within the vascular tissues
+During pollen development, mainly expressed in uninucleate microspores (UNMS) and bicellular pollen (BICP), and fades out after the immature tricellular pollen (TRCP) stage (PubMed:21705385). Mostly observed in rapidly growing tissues through all developmental stages, such as shoot apices, distal root regions, and developing sepals (PubMed:25315606)
+Expressed in neurons of the head and tail from embryo to adult. Expressed in the hypodermis from the three-fold stage of embryogenesis; expression in the hypodermis subsequently decreases at L3 and is undetectable in adults
+Expressed from 14 hours embryos through to adulthood. There is a weak maternal contribution to early embryos
+Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2
+Detected along the length of the mesonephros at 9.5 to 10.5 dpc. At 11.0 dpc, detected in the mesenchyme of the gonads in both sexes and in mesonephros. At 11.5 dpc, sex-specific differentiation of the gonads begins, and Wnt4 is down-regulated in male gonads, but not in female gonads. Detected in mesenchyme cells underlying the newly formed Mullerian duct in females, but not in the Wolffian duct in males (PubMed:9989404). During kidney development, detected at 11.5 dpc in condensed mesenchymal cells on both sides of the stalk of the ureter. Detected on pretubular aggregates upon initiation of ureteric bud branching at 12.5 dpc. Detected on primitive tubular aggregates at 13.5 dpc. Detected on comma-shaped and S-shaped bodies by 14.5 dpc, and is restricted to kidney cortex by 16.5 dpc (PubMed:7990960)
+Expressed during the 5th larval instar (feeding) stage with a strong peak of expression in newly-molted larvae, and progressively lower peaks of expression at day 3 and day 7 of the 5th instar. No expression detected during the pupal stage
+Prominent expression detected in the developing hypothalamus and cerebellar primordium at Carnegie stage 23
+Ubiquitously expressed in the embryo, with a higher expression in the intestines
+Expression begins in the embryo and persists into larval and adult stages (PubMed:16310763). Expressed in the excretory duct cell, as well as other cells, at larval L3 stage (PubMed:16310763)
+Expressed maternally in the oocyte and shows uniform expression during the first half of embryogenesis, but becomes restricted to the brain and the nervous system during late embryogenesis
+Highly expressed in early trophozoite stages. Expression is then reduced in late trophozoites and elevated again in schizonts
+In sporulating mycelium and much less in germling and yeast
+During anther development, expressed in anther vacuolar tissue from stage 9 to stage 13
+Highly expressed at birth and up to day 3; expressed at lower levels in embryo and adult
+Present in testes beginning at postnatal day 5 (at protein level)
+After flowering, expressed in the stigma and anthers
+Expressed exclusively in embryos before or up to the 8-cell stage
+The protein is expressed in embryos at 18.5 dpc
+Expressed from day 12 of gestation in pancreatic structures
+Expression is cell cycle regulated with a peak in G1 phase
+Expressed in anthers of developing flowers during meiosis, tapetal cell death stage and microspore stage
+Expressed in spermatocytes from P10 to adulthood. Expressed in oocytes from 12.5 dpc to P9. Primarily detected in spermatocytes and less in spermatids or spermatogonia. Abundant in the nuclei of pachytene and zygotene cells. Also detected in nuclei of diplotene cells (at protein level)
+At stage 12.5 dpc, expressed at high level in the developing liver and kidneys (PubMed:11948190). At 18.5 dpc, preferentially expressed in the thymus and in regions of the nervous system (PubMed:11948190). Within the developing trunk, preferential expression persisted in the liver and became restricted to the cortical region of the kidney, spleen, adrenal gland, and to stomach and intestinal epithelia (PubMed:11948190). From 14.5 dpc to 18.5 dpc, as well as in the adult, expressed at the highest level in thymus (PubMed:11948190). Expression is particularly high in the subcapsular zone of the thymus where immature lymphocytes proliferate (PubMed:11948190)
+Expressed in basal and suprabasal layers of the epidermis as well as within the developing hair follicles and the lumen of the esophagus at 18 dpc
+Transiently expressed in flowers
+Expressed in body wall muscles from 3.5-fold stage of embryogenesis with highest levels in late embryos and L1 stage larvae. Lower levels persist to adulthood
+Expressed in testis at 7 dpc
+Appears in prophase cells and remains present until metaphase. Strongly decreases at the onset of anaphase and completely disappears at telophase. Not present in interphase cells (at protein level)
+Expressed at low levels at 7-9 gestational weeks and then increases at later stages, including in the non-cortical plate region at gestational week 21, containing the outer-subventricular zone
+Abundant in 18-24 week old fetal brain. Postnatally its expression decline and only minimal levels were present in adulthood
+Accumulates exclusively in the root endodermis at a late developmental stage. Strongly expressed in endodermal cells overlaying lateral root primordia and later in a collar of endodermal cells at the base of the emerged lateral root. Also expressed in the floral organ abscission zone in cells that detach along with the shed organs
+It is first seen in the dorsal portion of the embryo just after cellularization and is expressed at high levels during early embryogenesis and as development progresses high levels are seen in the dorsal epidermis
+At 9.5 dpc, it is expressed in the periphery of cardiac myocytes in the looped cardiac tube of the developing heart (PubMed:10949023). In skeletal muscle, expression increases during muscle maturation (PubMed:10949023)
+In the fetal liver, expressed from day 14 to day 17 after conception
+Present in the unfertilized egg through to the blastula stage where it is distributed uniformly. Levels drop rapidly at four hours development, remain very low until 10 hours, then gradually increase from 12 hours with a rapid increase at 48 hours. At 48 hours it is concentrated in the region of the gill arches. Also present in the adult
+Expression is induced during seed desiccation and imbibition
+Expressed in Sertoli cells from 15.5 dpc onwards (at protein level)
+Detected in embryonic brain cortex at 15 dpc, and at clearly lower levels in adult brain cortex, hippocampus and in cerebellum Purkinje cells (at protein level) (PubMed:25519132). Very low and barely detectable in embryonic brain at 11 dpc. Detected in the developing brain cortex, thalamus and cerebellum at 12 and 14 dpc. Uniformly expressed all along the preplate at 13 dpc. At 16 dpc, highly expressed in neurons in deep and superficial layers of the frontal cortical region of the preplate, with much lower expression in the caudal region or the preplate. Highly expressed in thalamus at 14 dpc, and at much lower levels in adults. Highly expressed in hippocampus after 13 dpc; expression levels increase subsequently and are high in dentate gyrus and the CA region of the hippocampus at 19 dpc. Expression in dentate gyrus, granule cell layer and the CA region of the hippocampus continues in neonates and into adulthood
+Differentially expressed during hematopoietic differentiation. Isoform AML1-B is readily detectable in undifferentiated embryonic stem (es) cells and peak expression is seen on day 6 of differentiation, followed by a gradual decline thereafter. Isoform AML1-C is undetectable in undifferentiated es cells, but is gradually up-regulated along with differentiation and reaches its highest levels on day 8 and this expression is maintained through day 12. Isoform 5 is expressed at high levels at 6-8 dpc and then levels decrease on 12 dpc. Isoform 4 expression is high throughout T-cell development, declines with natural killer cell maturation, and appears to be transiently reduced and then restored during B-cell development
+Detected in proliferating fetal granule cell precursors at embryonic day 16.5, in proliferating and post-mitotic granule cells at postnatal days 3 and 10. Expression in cerebellar Purkinje cells is strong at postnatal days 10 and 21
+Expressed in both miracidia (larval) and adult worms
+In spleen, expression is down-regulated in aged mice
+High levels of maternal transcript in unfertilized eggs. High levels up to blastocyst stage
+AT 11.5 dpc, expressed in the developing snout region, eye and limb buds. At 13.5 dpc, highly enriched in the lips, palatal shelves (secondary palate), and developing limb buds
+Locates to the apical domain only during the final stages of kidney proximal tubule development
+Coordinately expressed in partially overlapping domains during wing development
+At 24 hour postfertilization (hpf), significant expression is observed in the developing brain, including the tectum and telencephalon. Expression is also observed around the trigeminal ganglion, at the mid-hindbrain boundary, and throughout the hindbrain. At 36 hpf, additional expression is observed in the cerebellum and within the retina. At 48 hpf, stronger and more widespread expression is detected throughout the developing eyes brain
+At stage 16, in the posterior trunk region, expressed in the neural crest and in neural crest cells migrating into the sclerotome. From stages 24 to 27, expressed in the liver and in elements of the developing peripheral nervous system derived from the neural crest, including dorsal root ganglia, cranial ganglia, enteric ganglia and peripheral nerve tracts
+Expressed in dorsal regions of embryos at late gastrula stage, transiently expressed in the developmental process of 3-fold embryo to L1-L2 larval stage
+Increased expression throughout embryo development. Ubiquitous expression at 9.5 dpc and 11.5 dpc with lower expression at 9.5 dpc
+Detected in differentiated oligodendrocytes, from embryos at 14.5 dpc through to the postnatal stage
+First detected in the otic placode at 16.5 hours post-fertilization (hpf). Detected in the developing inner ear sensory epithelium at 24 hpf. Detected in hair cells of the sensory epithelium at 4 days post-fertilization (dpf). At 5 dpf, levels are much reduced in the otolith organs, and not detectable at 7 dpf. Detected in neuromasts and in the lateral line system at 5 dpf and 7 dpf
+Expressed in developing myotubes at 11.5 dpc. Expressed in the dermomyotome component of the somites at 12.5 dpc. Expressed in fibroblasts at 13 dpc. Expressed in the perichondrial mesenchymal cells from the cartilage primordium of the ribs and in the scattered developing intercostal muscle fibs at 16.5 dpc (at protein level). Expressed in the primitive mesenchymal condensation adjacent to the eye and in primitive mesenchymal cells surrounding the cartilaginous primordia of the bones at 13.5 dpc
+Expressed in the embryo from stage 16. In the larva, abundant at the end of both the second and third instar but is almost undetectable in freshly hatched third instar larvae and declines in white prepupae. Also expressed in the adult
+Expressed during early fetal stages
+Hardly expressed in young leaves at 14 days after sowing (DAS). Expression detected in adult leaves at 28 DAS and increases with growing stage
+Expressed in the embryo at the heart and torpedo stages. Highly expressed throughout the vegetative shoot apex
+Expressed in fetal skeletal muscle
+In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood
+Expression is seen first at day 45 of post-natal development (post-meiotic transcription)
+During the sow estrus cycle, highest levels are found in the hypothalamus at proestrus and estrus with a significant drop at metestrus and an increase at diestrus. In the pituitary gland, expression increases from proestrus to estrus, drops at metestrus and increases at diestrus. In the ovary, expression increases from proestrus to estrus, drops at metestrus and remains at a similar level at diestrus. During boar postnatal development, expression peaks in the hypothalamus at day 30 and decreases thereafter. In the pituitary gland, expression peaks at day 60, drops slightly at day 90 and increases again at day 120. In the testis, expression drops from day 3 to day 30 with peak levels at day 90 and a decrease at day 120
+Isoform C is expressed in embryos, larvae and adults
+Expressed in V5 postdeirid lineage cells in L2 larvae (PubMed:31386623). Expressed in the nine ray lineage Rn.a neuroblasts and their progeny, Rn.aa and Rn.ap (PubMed:11076762)
+In fetal kidney (25 weeks of gestation), expressed in immature podocytes from the S-shaped-body stage to the capillary loop stage. Expression decreases along glomerular maturation (at protein level). In mature glomeruli, expressed at the periphery of the glomerular tuft, most probably in the cell body of mature podocytes. Also detected in mature tubules (at protein level)
+First observed in the distal and middle regions of cotyledons of torpedo-shaped embryos. Later localized in bending cotyledon, and mature embryos, but no signals were detected in the presumptive shoot apical meristem (SAM) and the boundary region during embryogenesis. During flower development, first observed throughout the floral meristem. Later expressed in rapidly growing floral primordia. Detected to a lower extent in vegetative primordia. During flower development, first observed throughout the floral meristem. Expressed during ovule development (PubMed:25378179)
+Levels decrease during early postnatal development after which it remains stable into adulthood and this decrease occurs to a greater degree in the frontal cortex compared to the hippocampus (at protein level)
+Expressed throughout development from embryos to adults (PubMed:15238518, PubMed:27650246). Not expressed in somatic cells of embryos (PubMed:28806108). First expressed in 1-cell embryos, and expression continues until the 24-cell stage (PubMed:15238518). Highly expressed in early stage embryos (PubMed:19167332). Expression decreases after the 24-cell stage and is negligible throughout the rest of embryogenesis and early stages of larval development (PubMed:15238518, PubMed:19167332). During larval development, first expressed in the germline of L3 stage larvae (PubMed:15238518)
+Expressed in embryos, L1 larvae and adult hermaphrodites and decreases drastically between the L2 and L4 larval stages (at protein level) (PubMed:12175490, PubMed:17215300). In late embryos and young larvae, expressed at higher levels in the two primordial germ cells (PGCs), Z2 and Z3, than in somatic blastomeres (PubMed:17215300, PubMed:30929290). Expressed at a relatively constant level throughout the distal end of the gonad at the L1 stage, with no decrease as cells enter into meiotic prophase (PubMed:25564623)
+Detected at 11.5 dpc and expression is seen throughout the proliferating cortex neuroepithelium, developing medulla, and spinal cord. At 12.5 dpc found in the nasal epithelium and at 13.5 dpc detected in the trigeminal ganglia, dorsal root ganglia and the ganglion cell layer of the retina. At 14 dpc to 15 dpc, expressed at high levels in the brain and spinal cord and then levels subsequently decrease
+Expression in embryos increases as development proceeds (at protein level)
+First detected in the anterior neural keel at 7 somites. By 12 somites, expression is more robust in the medial forebrain and forming eyes. By 16 somites, expression remains within the optic stalk and is predominantly restricted to tissue ventral to the optic stalk and ventral preoptic area. In addition to optic stalk and ventral preoptic area, weakly expressed in the ventral retina near the choroid fissure region by 24 hpf (hours post-fertilization). At 48 hpf, expression remains prominent in the ventral preoptic area but is much reduced in the choroid fissure and optic stalk
+Expressed during the asexual blood stage, including in rings, trophozoites and schizonts (at protein level) (PubMed:31413195, PubMed:31734953). Expressed in male and female gametocytes from stage II to stage V (at protein level) (PubMed:31413195, PubMed:31734953)
+Expressed throughout glomerulogenesis
+Expression begins at the 50-cell embryonic stage and continues throughout development (PubMed:19528325). Expressed in the HSNL motor neuron from early larval stage L4 to the young adult stage (PubMed:17626846)
+Expressed both maternally and zygotically. Maternal expression levels are low and become further reduced after fertilization. Zygotic expression begins at the mid-blastula transition and peaks during the gastrula/neurula stages before declining again by stage 34
+Expressed at 18 dpc in sympathetic ganglia
+First detected at the aggregation stage and peaks during culmination
+First expressed at 48 hours post-fertilization (hpf). Expressed in dorsal midbrain and in retinal ganglion cells
+Accumulates in developing embryos and in the primordia of cotyledons and leaves (PubMed:22058024). Accumulates mostly in the inflorescence meristem and in floral primordia. Low levels in the inflorescence meristem dome, but high levels in the floral primordia already in early stages. Accumulates progressively in floral organ primordia to become concentrated in the primordia of stamens and carpels. At the later stages of floral development, expressed primarily in developing microspores in the stamens and ovules in the carpels (PubMed:22357616)
+In roots, observed at high levels at the rosette stage and remains expressed during all development stages (PubMed:29872026). Particularly observed in stems of budding plants (PubMed:29872026). Accumulates in the wall of capsules at all stages (PubMed:29872026)
+Expressed in all tissues throughout development, with maximum levels reached during metamorphosis and maintained in the adult
+Expressed in the ovarian oocytes from the primary follicle stage to the antral follicle stage (at protein level). Expressed in preimplantation embryos until the early 2-cell stage, decreasing thereafter
+Expressed during the asexual blood stage; expression is low in rings, increases during the trophozoite stage, peaks during the late trophozoites and decreases in schizonts
+Expressed in spinal cord and brain at 19 dpc through adulthood
+Expressed in embryos and in adults
+Expressed in the neural plate at stage 14 and expression continues throughout embryonic development. Expressed in the developing retina
+Expressed in seam cells throughout postembryonic development. Expressed in the developing gonad, distal tip cells and spermatheca from larval stage L3
+Expressed during development; especially from early development (PubMed:16086850)
+Accumulates in the stele, especially at the phloem pole, of the mature region of the primary roots
+First observed after gastrulation and persists into the first larval stages and in the adult
+Expressed in both sexually mature and immature cells at the growth phase
+Heat shock cognate proteins are expressed constitutively during normal development. Up-regulated in aspidocytes, a resistant cell type induced from amoebae by a range of toxins including heavy metals and antibiotics
+Expressed only during early lactation phase
+Expressed broadly throughout most of development
+Expressed in embryonic stem cells and embryonic fibroblasts (PubMed:11418248). Detected 1 week after birth in developing ovary (PubMed:27663720)
+Expressed in fetal brain, lung and kidney
+The level of PCP rises sharply at larval-pupal transformation
+Expression increases during transition to multi-cellular stages, and levels remain constantly high throughout the rest of development
+Expressed predominantly in fetal tissues and at lower levels in adult
+Highly expressed in ductus arteriosus prenatally, expression declines rapildy after birth
+In roots, restricted to the root apical meristem (RAM) in a pattern positioned just above the quiescent center (QC), mainly in endodermis, cortex and vascular tissues, with strongest levels within cells in the QC vicinity (PubMed:23370719, PubMed:22421050). Slightly observed in the epidermis (PubMed:23370719). Induced early during lateral root formation (PubMed:23370719)
+Expressed in the testes at 13.5 dpc (PubMed:10359848, PubMed:29848638). Also expressed in the mesonephros, metanephros, brain, lung, heart and stomach at 13.5 dpc (PubMed:10359848). Expressed in the testes at 14.5 dpc (PubMed:29848638). Expressed in the ovary at 13.5 and 14.5 dpc (PubMed:29848638). Expressed weakly in the testes at postnatal day 14 (P14), strongly expressed from P21 onwards (PubMed:29866902). Expressed in the nucleus of pachytene spermatocytes in stages 5 to 6 of spermatogenesis (PubMed:29866902). Expressed in round spermatids and increased expression in pachytene spermatocytes in stages 7 to 8 of spermatogenesis (PubMed:29866902). Expressed in the nucleus of diplotene spermatocytes in stages 11 to 12 of spermatogenesis, however expression in the nuclei of spermatids is lost (PubMed:29866902)
+Present in larvae and in adult parasites
+During male gametophyte development, strongly expressed in microspores and bicellular pollen, but decrease gradually during pollen maturation in tricellular pollen to finally disappear in mature pollen
+Expressed during the slug stage in prestalk cells leading later to the fruiting body
+Highly expressed during microspore development
+Expressed abundantly under sexual development conditions
+Expressed in the P cell lineage in hermaphrodites during the larval L1 stage (at protein level) (PubMed:12091304, PubMed:19386265). Expressed weakly in all 12 P cells just before P-cell migration, as migration occurs and in both P cell daughters after division in the ventral cord (at protein level) (PubMed:12091304). After division, expression decreases drastically in the Pn.a cell lineage; it continues in the Pn.p cells, and subsequently decreases at different rates in different Pn.p cells (at protein level) (PubMed:12091304). Also expressed in the B and Y cells in the tail region during L1 (PubMed:12091304, PubMed:19386265). Expressed in the early embryo in all MS descendants and in several related anterior sublineages of ABa that arise at the 50-cell stage (PubMed:35660370). In later embryos, expression occurs in two anterior sublineages of MS, in several anterior ABp-derived sublineages, and in the Pn ventral epidermal blast cells (PubMed:35660370). Expressed in many dividing cells in the embryo; at the end of gastrulation, expressed in some neuroblasts on the ventral side (PubMed:19386265). Expressed in the embryo at epidermal closure, at similar levels, in the daughters of the ABpl/rpapaa neuroblast, the anterior SMDD/AIY neuroblast, and the posterior SIAD/SIBV neuroblast (PubMed:19386265, PubMed:26073017). Expression in the AIY/SMDD lineage is transient and is lost during larval and adult stages (PubMed:19386265)
+From the prepubertal period to day 5.5 of pregnancy is weakly expressed. From day 5.5 of pregnancy, an increase of expression is observed. At day 12.5 expression is higher
+Detectable at 4 hours post-fertilization (hpf), expression levels peaked at 24 hpf and gradually decreased afterwards. Expression become detectable when skeletal muscle differentiation commences at 14-16 somites with an anteropsterior gradient. Myocardial expression starts at 22 hpf in the forming heart tube and, at 24 hpf, is confined to differentiated cardiac muscles cells. At 24 hpf, is also expressed in the entire myotome. At 48 and 72 hpf, expression in the trunk muscle cells disappeares, but is present in muscles cells of the pectoral fin bud and facial muscles
+Highly expressed in the developing embryo
+First detected at the NMJ at approximately 16.5 dpc, when NMJs have just formed. As the NMJ grows and matures, expression levels increase in concert with that of acetylcholine receptors. Levels stay relatively high until 14 days after birth, but decrease significantly by 21 days. Up-regulated during myogenic differentiation in C2C12 cells and during injury-induced muscle regeneration
+Detected in boundary cap cells at 11.5 dpc, expression is strongest between 15.5 and 17.5 dpc and is barely detectable at birth
+In the developing brain, it is homogenously distributed in the cortical plate, ventricular zone and ganglionic eminences at 15 dpc. A peak of expression in the cortex is observed at 16.5 dpc
+Detected in the apical inflorescence meristem, in bract primordia arising in its periphery and in floral meristems produced in the axils of bracts (stages 0-3). From stage 3 to stage 8, detected in all floral organs irrespective of their dorsoventral positions. From stage 9, barely detectable in bracts, sepals, and stamens. In the corolla, however, expression was maintained and enhanced in some regions. Within ventral and lateral petals at stage 9, asymmetric pattern of expression with high levels of transcripts in the inner epidermis of the furrow and very reduced levels in the remaining cell layers. In the dorsal petals, from stage 9 onward, detected but with a more even distribution across cell layers than in the ventral petal
+Highly expressed during the early stages of leaf, petal, integument, and embryo formation and fade away later in petal and leaf development
+Expressed throughout embryonic, larval and adult stages (at protein level)
+At stage 21, expressed in leg buds in a superficial proximomedial domain, expression is enhanced by stage 23. By stage 29, expression is elaborated to include both leg and wing. By stage 35, expressed in all muscle-to-bone attachment sites. Expressed also in a wing aponeurosis, a tendinous element arranged in flattened bands, and in some of the flattened sheets of connective tissue associated with muscle
+Detected in embryos (at protein level) (PubMed:29178643). First detected during the segmentation period of embryogenesis (PubMed:8330668). Detected in the developing brain and spinal cord (PubMed:8330668). Detected at constant levels in embryonic head throughout embryonic development, from 18 hpf to 5 dpf (PubMed:29178643). Widely expressed in embryos at 56 hpf (PubMed:29178643)
+In the developing ovary, high expression, especially of the longer isoform, at 12 days of age after birth. Expression restricted to the interstitial cells surrounding the follicles. Levels are further increased during ovarian maturation
+Expressed in L3 larvae (at protein level)
+Transient expression burst in Purkinje cells as the cerebellar cortex becomes functional (postnatal day 14), and in mesenchymal cells of the developing intervertebral disks of the spinal column
+During flower development, first observed in the late tricellular pollen grains
+Expressed during nectar secretion, while the flowers remain open
+Not detectable in testis in the first 3 weeks of life. The expression markedly increases at approximately the 3rd week after birth and continues to increase gradually into adulthood
+During development, expressed in oligodendrocyte progenitor cells and in the proliferative neuronal progenitors in the developing cerebellum. In the embryonic brain, not expressed in immature newborn neurons, except for the cells residing in the marginal zone of the embryonic telencephalon. As brain development proceeds during the postnatal stage, expressed in some populations of immature neurons, including the neocortical pyramidal neurons, hippocampal pyramidal neurons and granule cells migrating in the cerebellar cortex. In the adult brain, expression is confined in terminally differentiated neurons in the restricted forebrain regions
+Expressed 30 hours post-fertilization (hpf) in the anterior and posterior lateral line ganglia where it persisted until at least 48 hpf. Also expressed between 30 and 72 hpf in the telencephalon. Expressed in the ventral thalamus, ventral midbrain, ventral cerebellum, and ventral hindbrain from 30 hpf. By 48 hpf, expressed also in the dorsal thalamus and hypothalamus. At 72 hpf, weak expression was apparent in the habenulae
+Expressed both maternally and zygotically. Expressed in the germarium, at low levels during oogenesis stages 1-6, at a lower level during stages 7-9, strongly at stage 10, eventually accumulates in early embryos and later in development the expression decreases (at protein level)
+Detected in small intestine during embryogenesis, but expression is much higher in adult
+Expression of isoform 2 increases sharply during the first ten days of postnatal life, and also increases with increasing numbers of rhodopsin cells in the retina
+Upon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments
+Expression begins during cell cycle progression, between 12 and 24 hours after germination. Reach a maximum around mid-log phase and disappear during the stationary phase. Expressed in the central funnel of cells of migrating slugs and at the top of rising culminants. Not expressed until the slug stage
+Expressed at high level during early embryogenesis
+Expression decreases in embryo after day 16
+Expressed during parasite asexual blood stages, specifically at the ring and schizont stages, in free merozoites and to a lesser extent in trophozoites (at protein level)
+Expressed in both somatic cells and germ cells from the one-cell stage onwards
+First detected at the mid-blastula transition. In gastrula, detected at the marginal zone. In neurula, detected at the boundary between midbrain and hindbrain, and at the anterior neural ridge. In tadpoles, detected in telencephalon, diencephalon, at the boundary between midbrain and hindbrain, in ears and branchial arches
+Ubiquitously expressed throughout the embryo and the imaginal discs
+First detected at 14 dpc, levels increase by birth and remain strong in the adult brain (at protein level). Expressed widely in the nervous tissues during development
+Detected in 6 and 7-week-old testis
+Isoform 1 and isoform 2 are expressed during embryonic development. At 16 hpf, expressed in a few cells in the ventral dieencephalon. At 48 hpf, present in the preoptic area and ventral hypothalamus (at protein level)
+Expressed in fourth instar larvae
+Detected already at 9.5 dpc. At 10.5 dpc, expressed in the genital ridges of both sexes. At 14.5 dpc, during gonadal sexual differentiation, expression declines in the ovary, but is maintained in the testis, where it becomes restricted to Sertoli and germ cells in the developing seminiferous tubules of the testis. Accumulates primarily in Sertoli cells. From P1, appears in germ cells and reach high levels by P7, just before meiosis begins. From P7 through adult stage, present in Sertoli cells and undifferentiated germ cells, but not in differentiating germ cells
+Expressed at later stages of microgametogenesis, after the pollen has reached the tricellular stage and until pollen dehiscence (PubMed:22540348). Expressed during vein formation (PubMed:23437008)
+In flowers, first detected at the early anther development stages with stronger expression at stages 6 and 7 (PubMed:22694475). Also observed during ovule development with high levels during meiosis (PubMed:22694475)
+Expressed in prestalk pstO cells but not in pstA cells. Strongly expressed throughout development
+Expressed only during floral abscission
+Expressed in quiescent cells
+Found to be expressed throughout the ovarian cycle. Overexpressed during luteolysis, this could reflect the regression of capillaries that had developed pericyte contact in the midstage corpus luteum
+In the female gametophyte, accumulates in ovules and its neighboring sporophytic cells
+Expressed in embryos from 9-22 hours, but not detected in first and second instar larvae. Expressed in 3rd instar larvae and at high levels in pupae
+During brain development, expression decreases from 12 dpc to P0. Expressed predominantly but not restricted in the ventricular zone (VZ)/subventricular zone (SVZ), and peak expression is observed at 12.5 dpc, in which the cerebral cortex consists primarily of neural progenitor cells (NPCs). At 15.5 dpc, the expression decreases in the cerebral cortical plate. At 18.5 dpc, when the embryonic neurogenesis period nears its end, the expression throughout the cerebral cortex is lower than that at 12.5 dpc (at protein level)
+Associates with meiotic and mitotic chromosomes prior to the onset of dosage compensation and with hermaphrodite X chromosomes after the onset of dosage compensation (at protein level)
+Strongly enriched during the first 2 hours after fertilization but then declines and remains at low levels during development and adulthood
+Maternally and zygotically expressed. In early stages of egg chamber development, predominantly accumulated in the nuclei of nurse cells and oocyte. Enriched at the posterior of stage 10 oocytes which persists after fertilization, at the posterior of pre-blastoderm stage embryos
+At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord
+Present throughout the asexual cycle
+During flower development, Progressive accumlation in petals during the first 40 hours, peaking at full bloom, and fades out from 40 to 64 hours
+Expressed in embryonic ovaries at embryonic day 16.5
+Maximum expression 2 hours after sunrise. Low expression found 2 hours before and 8 hours after sunrise
+Expressed during all stages of development (at protein level)
+Expressed during deetiolation and during chloroplast to chromoplast transformation
+Found in the eggs and in embryos 4, 8 and 12 hours after fertilization, as well as on all days post-hatching. Level of expression decreases during embryonal development but increases 4-fold from day 1 to day 21 after hatching
+Earliest expression is in elongating embryos (PubMed:36688410). Expressed in embryos, larvae and adults (PubMed:12888489). Expressed in larvae in various cell types, including seam cells, vulva precursor cells, non-seam hypodermal cells, pharyngeal cells, and head neurons (PubMed:36688410). Expressed rhythmically, reaching peak levels just prior to each molt (PubMed:36688410). Expression diminishes, or is absent, in some tissues in adults (PubMed:36688410)
+Expression begins in 8.5-day-old embryos, peaks at 14-15 days and declines before birth
+Expression was first detected broadly at stage 9, and then localized in the posterior surface ectoderm overlying the presomitic mesoderm by stage 10-11 embryo
+Barely detectable in the brain of embryonic day 17 (17 dpc). Expressed in hippocampus and septum from postnatal day 1 (P1) and then in cerebellum and olfactory bulb from postnatal day 7 (P7)
+Expressed in progenitor cells in the dorsal third of the ventricular zone at 12.5 dpc. Expressed in newly emerging pontine gray nucleus (PGN) precursor cells of the extramural migratory stream (ems) between 12.5 and 14.5 dpc. Expressed in precerebellar mossy fiber (MF) neurons of the PGN (located either rostromedially or caudolaterally) persisted through at least P8 after birth (at protein level). In the early embryonic stage, it is expressed in the dorsal half of the neural tube and adjacent mesenchyme, and in the developing cerebellum it is expressed persistently in the granule cell lineage throughout the prenatal and postnatal periods
+Maternally expressed. At 24 hours post-fertilization (hpf), expressed mainly in head region
+Expressed at all developmental stages, but expression relative to adult is decreased in the L3 and dauer stages
+Detected only in the generative cell of late bicellular pollen and not in early bicellular pollen. Also expressed in uninucleate microspores
+Active between T2 and T6 of sporulation
+Expression in brain declines from 18 dpc to P8 and is undetectable from P14 onwards
+Expressed at all developmental stages, with a peak at early pollen development
+Very low expression in etiolated seedlings, but gradual increase upon illumination with a maximum after 6 hours. Expressed mainly in young plants grown under light conditions
+High levels of expression in early embryos, with levels decreasing slightly over the first 5 hours of embryogenesis (at protein level) (PubMed:28875934). Throughout development (PubMed:7742371, PubMed:9065696)
+Skeletal myogenesis is a major site of expression during normal embryogenesis. In addition, the ganglia of the developing peripheral nervous system and various embryonic epithelia, including those of kidney, lung and gut are also sites of expression
+Expressed at the first stage of pollen development in uninucleate microspores and bicellular pollen but not in tricellular and mature pollen
+Expressed in the entire embryo at the globular stage. Progressively restricted to the basal regions of the embryo that form the root meristem and the vasculature. After germination, detected in the differentiation zone of the stele that forms the inner layers of the root and in differentiating columella cells (CCs)
+Expression increases during the last half of pregnancy and is maximal during lactation
+Expressed at early stages of anther development in sporogenous cells and tapetum of anthers. Expression decreases in tapetum and increases in sporogenous cells at meiosis. At mature pollen stage, expressed in stigma, and then in proembryo after fertilization
+Expressed in the inflorescence meristem (IM) and young buds, particularly in stamen. Also detected in pollen grains
+Massively expressed in 10 days post-pollination seeds and then shows a steep decline as seed maturation proceeds
+Expression is especially strong in the hippocampus and throughout the CNS from embryonic periods through adulthood
+Constant expression throughout development
+Expression peaks 2-8 hours after egg laying. Expressed in the dorsal domains of gastrulation stage embryos. During mid-embryonic developmental stages, expressed in the central nervous system, the three thoracic segments and the cardiac precursor cells
+Expressed maximally between 2 and 3 weeks of age. Levels decrease sharply after 4 weeks around puberty. Expression is 50-fold higher in juveniles than adults with similar levels in male and female juveniles. Not expressed in castrated or ovariectomized adults
+Increasing expression in the ovary between fetal day 21 and postnatal day 2. Expression decreases thereafter to lower levels in adult ovaries
+First detected at 51 hours post-fertilization (hpf) in the ventral retina. At 60 hpf, expressed in a strip across the ventrotemporal retina. By 96 hpf, also expressed in the dorsal retina
+In the embryo, expressed in the liver at 9 dpc, in the skin and transiently in the telencephalon at 12 dpc, and in the kidney, small intestine and cerebellum at 15 dpc
+First detected at 7.5 dpc in the node at the distal tip of the egg cylinder and is largely confined to the ventral node. Between 8 dpc and 9 dpc, highly expressed in the node and newly formed notochord. At 12.5 dpc, expression is confined to the notochordal plate and caudal portion of the notochord
+Expressed both maternally and zygotically. Weakly expressed ubiquitously in early stage embryos. Present transiently in the blastula with levels dropping almost completely during gastrulation. Expression peaks during late somitogenesis, decreases at the end of somitogenesis, and then rises again at and after hatching. Strongly expressed in swimming larvae, juveniles and adults
+Within the bicellular pollen, only detected in the vegetative cell and not in the generative cell (PubMed:15927943). Expressed in the generative cell and in uninucleate microspores (PubMed:16915513)
+Expressed in AWA olfactory neurons at the L3 larval stage in males and hermaphrodites, but expressed decreases in males from the L4 stage to adulthood
+Expressed in 1-cell embryos and then decreased dramatically in 2- and 4-cell embryos. It increases transiently in 8-cell embryos and then vanishes completely at the morula stage (PubMed:15121843). Predominantly expressed at all stages both in cerebrum and in cerebellum containing mesencephalon. Expression increases during the embryonic stage with the highest expression at P0 and decreases. Expression increases from the embryo to P7 stage, with the highest expression at P7, and decreases in adult brain. At P7 expressed in the neurons in layers II-IV and those in layers V and VI of the cerebral cortex. At P7 expressed in cerebellum, granule neurons in the internal granule cell layer (PubMed:12626397)
+Mutations in spoVJ block sporulation at a late stage. Probably only functions late in development
+Isoform B is expressed both maternally and zygotically throughout development with highest level during mid-embryogenesis and adulthood. At these zygotic stages isoform D is also expressed
+Expressed in larvae and adults in neurons in the anterior ganglia (PubMed:10421632). Expressed in the precursor of serotonergic ADF neurons (PubMed:16168406). Expressed in the SMB sensory/inter/motor neurons at larval stage L1 (PubMed:26305787)
+Present at high levels in both cytoplasmic and membrane-associated forms in neonates. Levels of membrane-associated form are greatly reduced in the adult
+Expression is highest at the gastrula stage. Expressed preferentially in tissues of mesoderm origin, such as the notochord and some regions of the primitive ear
+Expressed at very low levels during early stages of leaf development, but up-regulated during leaf senescence
+Low levels in unfertilized eggs and during early cleavage, then rapidly increases in abundance between late morula and mesenchyme blastula stages to maximal levels maintained through subsequent stages
+First observed at HH4 in mesodermal progenitor cells surrounding the area of Hensen node and in the primitive streak. Expressed in the presomitic mesoderm and dynamically expressed in forming somites. Detected in the developing intermediate mesoderm at HH9 and in the mesonephric tubules and ducts by stage HH18. Expressed in the developing nervous system. Also observed in the limb bud and the developing heart
+At 4-10 weeks pc, strong expression in the developing central nervous system, kidneys, testis and lung. Differentially expressed within renal tubules
+Expressed in all blastomeres of the embryo from at least the 2-cell stage until approximately the 200-cell stage (at protein level) (PubMed:9521900). Expression becomes restricted mainly to epidermal cells and their precursors after 200 cell stage and during subsequent embryogenesis (at protein level) (PubMed:9521900). Expressed at high levels in newly hatched larvae, then decreases to a minimum at 4-6 hr after L1 stage larvae start feeding; expression increases for about 2 hr and decreases before each successive molt (PubMed:11416209). In L4 larvae, expressed in hypodermal cells of the head, vulval precursor cells of hermaphrodites, and hypodermal and tail cells of males (PubMed:33060131). Also expressed in the sperm-producing germlines of males and L4 hermaphrodites, but not in hermaphrodites producing only oocytes (PubMed:33060131)
+Up-regulated during myoblasts differentiation (at protein level)
+Its levels oscillate in plants grown in light/dark cycles with maxima between Zeitgeber time zt8 and zt12 (8-12 hours after onset of illumination) and minima around zt20
+Expressed from 1 post-fertilization (dpf) and expression increases until 4 dpf. Ubiquitously expressed at 5 dpf
+Rareley expressed between embryonic stages 17 and 24. Expression starts from stage 32
+May be incorporated into the tegument during the development of schistosomula, thus becoming a target for protective immunity during the migratory phase of the parasite
+First expressed during embryogenesis at the 1.5-fold stage, and in very few cells throughout development (PubMed:10716947). Expressed in L1 larvae in the posterior hindgut cells B and F and in later L1 stage in the B daughter cells B.a and B.p (PubMed:10716947). Also expressed in two posterior hypodermal nuclei of the large syncytial cell hyp7 and in the nervous system in two neurons of the lumbar ganglion (PubMed:10716947)
+In the developing embryo, expressed in the limb bud mesenchyme, in cranofacial mesenchyme, and in hindbrain neuroectoderm. At stages 20, 24 and 28 of embryonic development, expressed ununiformly in facial primordia. Present in lateral nasal processes, at edges and corners of frontonasal mass and in the anterior part of the maxillary primordia. Expressed in mesenchyme at all stages of facial development. In the developing limb, isoform Beta-1 is expressed limb bud mesenchyme and ectoderm, then become restricted within perichondrial regions and loose connective tissue of the limb, while isoform Beta-2, expressed in subsets of similar tissues, in the proximal limb mesenchyme and in the initial mesenchymal condensate. later abundantly expressed in cells lateral to the digit cartilage
+Expressed in fetal tissues, with highest levels in heart, lung, and kidney
+Expressed in the embryo 1 day after inbibition, and at low levels in developing seeds between 3 and 20 days after flowering
+Expressed in a dynamic and restricted pattern during the period of axon outgrowth
+In testis, expressed at low level until day 20, when round spermatids appear for the first time. After day 20, a sharp and constant increase of expression is observed
+Expression observed in trophoblast giant cells (TGCs), the placenta-derived cell lineage aligned at the boundary between the uterus and placenta, at 12.5 dpc. Expressions gradually decreased during placental maturation, and the signal is no more detectable in the cells at 18.5 dpc
+Gastrulation specific
+Initially detected during embryonic segmentation which persists for at least 4 weeks post hatching
+Sporulation-specific
+Present in aerial hyphae of sporulating cultures (at protein level) (PubMed:12832396, PubMed:17462011). Strongest expression in spores, with weaker expression in aerial hyphae
+In inflorescences, accumulates mainly in mature pistils (PubMed:27524487). In developing ovules, observed at the micropylar region in a polarized localization of the synergid cells and in inner integument surrounding the female gametophytes (at protein level) (PubMed:27524487). In mature ovules, present in the filiform apparatus and in the integuments at the micropylar region (PubMed:27524487). Levels fade out in ovules after pollination and subsequent fertilization (PubMed:27524487)
+Found only in adults and late pupae
+At 2 dpf, strongly expressed in the developing eyes, as well as midbrain and hindbrain regions. In 3 dpf larvae, expressed in the upper rhombic lip. At 3 dpf, expression in the retina is weak and becomes spatially restricted in the inner nuclear layer. Weakly expressed in the forebrain region
+At 16.5 dpc, present in rib cartilage (at protein level)
+High levels are present in the logarithmic growth phase of the promastigote stage
+There is a transient increase in cortistatin-expressing cells in the second postnatal week in all cortical areas and in the dentate gyrus. A transient expression is observed in the hilar region at P16
+Major expression in dorsal root ganglia and peripheral nerves, with small amounts in connective tissues like calvaria and skin
+Expressed primarily in developing cotyledons (from emerging green cotyledons to approximately 10 days old); very low levels in hypocotyls and no measurable expression in roots
+Expressed during the redifferentiation of pigmented epithelial cells (PEC)
+High levels are seen in early flower development, gradually decreases in later stages and is absent after fertilization
+Expressed in both prestalk and prespore cells. Expression becomes strong after 12 hours of development and peaks at 16 hours
+Detected in the brain at 12 dpc with increasing level reaching a peak within 2 weeks after birth
+Expressed during late spermiogenesis and accumulates in mature spermatozoa
+Expressed as the predominant form of mapk14 both maternally and zygotically throughout development
+Expressed during development; especially between 8-18 hours of development. Expressed (at protein level)
+Expression is induced in mycelia after 24 hours of growth. Maximal expression is reached at about 42 hours and expression is slightly decayed after 48 hours
+Primarily present around the midvein in seedlings. Accumulates gradually in expanding leaves, reaching a maximum in fully expanded leaves in both primary and secondary veins
+Expressed as early as day 7 and in equal amounts during gestation
+Expressed at all stages of testicular development with the highest expression levels found in testes of 21-day-old mice (PubMed:8879495). Expressed at the outer limiting membrane of the retina at 3 months of age (PubMed:23001562). Expression is restricted to the lens stalk region between 10 and 11 dpc. At later stages (17.5 dpc), it is expressed in the developing lens and corneal endothelium (PubMed:31650526)
+First detected in cerebellum at postnatal day 0 (P0), increased with age and peaked at P7, and then rapidly decreased to adult levels by P21
+Detected in the mature female gametophyte, in the synergids and central cell. Mostly expressed in embryos (but not the suspensor) and endosperm of preglobular stage seeds. Present in pollen as well as in pollen tubes
+First expressed just prior to gastrulation
+First strongly expressed in restricted domains at 8.5 dpc where it is highest in the tail bud. At 10.5 dpc, expressed in the branchial arches, limb bud, tail bud and posterior dorsal neural tube. Later, expressed in terminally-differentiated odontoblasts, the nasal epithelium, retina and specific regions of the brain
+Expressed exclusively during sporulation (at protein level)
+Detected in larvae. May be expressed in the oncospere
+Present in aerial hyphae of sporulating cultures (at protein level) (PubMed:12832396, PubMed:17462011). Strongest expression in spores, with weaker expression in aerial hyphae (PubMed:12832397)
+Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain
+Detected in embryonic notochord
+First observed in seedlings at rosette initiation sites (PubMed:22189440). In stems, expressed in the epidermal layer and the underlying few cell layers, but not in the inner cortex and vascular bundles (PubMed:22166367, PubMed:22189440). In flowers, observed in the epidermis, endothecium and tapetum of anthers, but not in the microspores (PubMed:22166367). In siliques, accumulates in the replum and receptacle (PubMed:22166367). In roots, present in emerging root primordia and in the root cap throughout lateral and primary root development (PubMed:22166367). Observed in pollen grains of anther tissues at petal differentiation stage (PubMed:22189440)
+On the day of birth, expressed in the regions of the brain including hippocampus, thalamic nuclei and cortex (PubMed:9872744). Abundant in brain cortex and cerebellum throughout postnatal development whereas its expression in spinal cord gradually decreases (PubMed:9872317)
+Expressed at all stages of brain development and increases significantly between postnatal days 7 and 14
+Expressed predominantly during mid-maturation of seed and down-regulated during late maturation. Up-regulated 12 hours after seed imbibition
+Expressed in most cells during embryogenesis (PubMed:25124690). Expressed most strongly in the egg with expression present in L1 but reducing through to L3 where it is very weak. No expression was found in L4. Strong expression is also seen in egg-laying adults and post-reproductive adults
+Expression increases significantly during spermatogenesis with a 70-fold increase from day 7 testis to day 30 testis. First detected in the late pachytene stage, increases in diplotene and secondary spermatocytes and reaches its highest levels in round spermatids
+Expression starts in the neural plate at mid-gastrulation. Later on its expression becomes restricted to discrete regions of the central nervous system and to derivatives of the neural crest cells. Expressed as well in the primordial cells of the skeleton in mice embryos at 13.5 dpc
+First expressed at low levels at P15 in the epididymis. Expression increases from P30 onward. Reaches its highest level at P120 and remains at a stable level in mature animals
+Expressed at 5.5 dpc in the distal visceral endoderm. Expression increases at 6.5 dpc in the most anterior part of the visceral endoderm. At 7.0 dpc expression spreads over the anterior visceral endoderm and occurs in the anterior ectoderm. At 7.75 dpc expressed in the definitive anterior endoderm, anterior mesoderm and anterior neuroectoderm. At 8.25 dpc, when the headfold is formed, expressed in the forebrain, foregut and in segmented somites. At 12.5 dpc, expressed in cerebrum cortex, lateral ganglionic eminences, preoptic area neuroepithelium, hypothalamus, ventral part of otic placode including adjacent mesenchyme, a part of the tongue, endocardial cushion around aortic valve, myotome and muscle primordia
+By 7 somites, detected in the anterior brain and expression is strong within the optic stalks, preoptic area and telencephalon by 12 somites. By 16 somites, expression in the telencephalon is reduced but that in the preoptic area, optic stalk and ventral retina remains and this pattern of expression is similar at 24 hpf (hours post-fertilization). By 48 hpf, expression is restricted to the ventral preoptic area, anterior dorsal hypothalamus and ventral retina
+Up-regulated during mitosis and down-regulated in the G1 phase
+First detected in embryonic brain at 12 dpc. Expression increases thereafter, is highest in brain from pups 4 days after birth, and then decreases again. Expression is decreased 14 days after birth, and not detectable in adult brain
+Detected in cultured cells, immediately after seeding and before formation of focal adhesions (at protein level)
+Weakly detectable in the first 3 postnatal days, but increases during the initial 2 weeks after birth
+Induced in the midgut of female after blood meal
+In developing nodes of Ranvier, it is localized in the sciatic nerve at postnatal days 3 and 10, during the process of myelination and maturation of the nodes
+Expressed in developing microspores during pollen development. First observed at the tetrad stage, and later accumulates in an early unicellular stage. Levels decrease as the pollen grain matures
+Induced in 13.5 dpc in the embryonic ovary, expression persists at least until 18.5 dpc (PubMed:32032549). In testes, expressed in spermatocytes during the preleptotene stage in the stage VII-VIII seminiferous tubules (at protein level) (PubMed:32032549)
+Expressed in unfertilized eggs (at protein level). Most highly enriched in the cortex of the newly fertilized egg. Becomes concentrated in the blastodisc by 30 minutes post-insemination and remains distributed among all regions of the embryo, excluding yolk. In the pharyngula stage (24 hours post-fertilization), observed all over the embryo, with highest levels in the eyes and central nervous system and somites (at protein level)
+In developing flowers, only observed in stamens of young flowers, but disappears in old flowers
+Higher levels of expression found in adult liver than in fetal liver
+Expressed throughout fetal nephrogenesis, abdominal and thoracic organogenesis, and nervous system development between day 10.5 and day 16.5. In the developing lung, differential expression within the endodermally derived cuboidal epithelial lining of the terminal and respiratory bronchioles. In the developing eye, high expression in both the inner and outer neuroblastic layers of the retina and lens
+At the threefold embryonic stage, expressed asymmetrically in one of the two AWC neurons (PubMed:19204119). A subset of embryos show bilateral expression in AWC neurons, but this declines after larval stage L1 (PubMed:19204119)
+Broadly expressed during development. Expression begins to increase at 7.5 dpc, peaks at 10.5-11.5 dpc, and decreases from 14.5 dpc. Weakly expressed at late embryonic stages
+Expressed in inner ear hair cells at 16.5 dpc. Expressed postnatally in inner and outer hair cells of the cochlear, as well as in vestibular hair cells. At the cochlear apex, levels are low at P1 and increased thereafter. After P7, hardly detectable at the protein level, while mRNA levels remains high in adult hair cells
+In flowers, present in the anther tapetum early in anther development and later in the pollen coat (PubMed:11929861, PubMed:26305561). Upon tapetum degeneration, associated with tapetosomal debris 'in transit' to the pollen cell wall in the anther locule (PubMed:26305561)
+Expression is cell cycle dependent with the highest levels at the end of G1 phase, peaking at the G1-S transition
+At the 10-somite stage, expressed strongly in the paraxial mesoderm with an anterior expression limit at somite 6. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 2/somite 3 boundary
+Expressed broadly at high levels in the whole embryo and becomes progressively restricted to the central nervous system by 14.5 dpc. Extensively expressed across the central nervous system through late embryogenesis and during postnatal development, with a peak of expression around the first week after birth
+Early expressed in the whole plant, but was restricted to lower stems, flower buds and roots in the mature plant (6 weeks old)
+Expressed from 16 dpc in ovary and testis and during P6-P16 during differentiation of ovarian follicles
+Expressed in fetal tissues including skin, small intestine, liver, kidney, lung, muscle, heart and brain
+Expressed in 50 day old embryo
+Expressed in the midgut at the prepupal stage of the last larval instar
+Expressed both maternally and zygotically. Expression starts at late blastula stages in the dorsal marginal zone and persists throughout gastrulation in the prechordal plat and the presumptive notochord, both derivatives of the Spemann organizer. At later stages expression is initiated at several new sites, including the roof plate of the neural tube and skeletogenic cells in the branchial arches
+Preferentially expressed at the G1/S boundary during the cell cycle in synchronized cultures of Catharanthus roseus cells. CYC02 is also expressed in cells arrested at the G1 phase
+Expressed in embryos, larvae and adult. Highest level of expression is in early embryos (PubMed:11110798). Expressed in the nerve ring and ventral nerve cord in L1 larvae (PubMed:11441002)
+Present in the developing cerebral cortex from embryonic day 12.5 dpc, with a peak at 14.5 dpc followed by a decrease from 18.5 dpc (at protein level) (PubMed:31462248). Selectively expressed in radial glial cells of cerebral cortex from 12.5 to 16.5 dpc, but not in intermediate progenitor cells (IPCs) or neocortical neurons (at protein level) (PubMed:31462248). Highly expressed in callosal oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs) from postnatal day 7 to postnatal day 28 (PubMed:31174389)
+Isoform 1 is expressed in fetal heart
+Undetectable at the gastrula stage at 7.5 hours post-fertilization (hpf) but readily observable during neurulation at 16 and 22 hpf where expression is restricted to the neural rod at 16 hpf and the neural tube at 22 and 28 hpf
+Expressed in fetal lung, intestine and skin. Secreted to the extracellular matrix (ECM) in certain fetal epithelia
+In the embryo, highly expressed at 17 dpc. Detected in all postnatal stages, but highest expression is found at day 160 after birth
+In embryos (at protein level)
+In young seedlings, expressed in hypocotyls and cotyledons. In older seedlings, limited to the outer epidermal cell layer of leaves and petioles (including guard cells). Present in trichomes and hydathodes. In flowers, detected in sepals and siliques
+In spermatocytes, not observed on asynapsed chromosomes in leptotene and appears on synapsed regions in zygotene and on the fully synapsed chromosomes in early pachytene. Disappears in late pachytene and is not observed in diplotene spermatocytes. A similar localization is detected on female meiotic chromosomes (at protein level)
+Expressed both maternally and zygotically. Expressed at the cleavage stage, with expression levels remaining constant throughout early embryogenesis, with a slight increase at the late gastrula stage
+Expressed in the central cell before fertilization and in the endosperm of seeds from the time of fertilization
+In laboratory strains, is a transition-phase protein that is expressed early in spore formation, as cells enter stationary phase (PubMed:10049401, PubMed:10368135, PubMed:10464223). Expression can occur as cells enter stationary phase even under sporulation-repressing conditions (PubMed:10464223)
+Expressed during ovarian development. The highest expression level is detected at stages I (immature with gonado-somatic index (GSI) <2%) and II (late immature with GSI 2% to 3%) of ovarian maturation. Expression decreases from stage III (early mature with GSI 3% to 6%) to V (ripe with GSI >9%), but increases in between at stage IV (late mature with GSI 6% to 9%) of ovarian maturation
+Expressed in fetal tissues and higher levels were detected in placenta and fetal lung
+During flower development, abundantly present in the apical meristem. During pollen development, there are high levels in pollen mother cells and it accumulates gradually to reach a peak during the tetrad stage. Fades out in mature pollen. Also present in tapetal cells and at stigmatic surface of the stigma
+At 15 dpc highly expressed in developing skeletal muscles, tongue, sternocephalic and tail. Weaker expression is seen in the heart atrium and ventricle. Expressed in a circular pattern in the intestine
+Expressed in the globular stage embryo 2 days after pollination (DAP) in a restricted small region just below the center of the ventral region of the embryo, where the shoot apex arises later. From 3 to 4 DAP expressed in an enlarged ventral region of embryo, corresponding to the expected epiblast and radicle, respectively. At the shoot apex differentiation stage (4-5 DAP), expressed in the shoot apex, epiblast, radicle primordia, and in their intervening tissues. Expression in the radicle is observed in the cells surrounding the root apical meristem in a donut shape but not in the meristem. During the first and second leaf primordium formation, expression pattern is maintained, but decreases. During inflorescence development, expressed only in the corpus of the rachis primordium but not in the tunica layer (L1). After floral induction, expressed in both tunica and corpus but not in floral organ primordia. Later in flower development, expressed in the corpus of the floral meristem
+At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 6. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 3/somite 4 boundary; also expressed in bilateral domains adjacent to the anterior spinal cord and ventrally along the trunk in the pronephric ducts
+Both sporozoites and intracellular stages of life cycle
+In placenta, at 7.5 dpc highly expressed in ectoplacental cone, endoderm and in giant cells, and at 9.5 dpc restricted mainly to the labyrinth layer (at protein level). In placenta, most highly expressed during early gestation (between 9.5 and 10.5 dpc)
+Increased expression until 5 days after germination and then declines during growth under constant darkness
+First detected during late gastrulation, found in the prospective neuroepithelium domain around 100% epiboly and begins to constrict along the neuroaxis by the end of gastrulation - around 10 hours post-fertilization (hpf). By 12 hpf expression is restricted in two regions of the neuroepithelium of the prospective hindbrain; rhombomeres 3 and 5. Around 14 hpf neural crest migration begins from the dorsal surface of R5 moving caudally into R6 and then ventrally towards the pharyngeal arches. Crest migration is not apparent at or after 16 hpf and no migration is seen from R3. Expression is down-regulated first in R3 around 26 hpf and later in R5 around 30 hpf
+Transcription of this protein is induced at the time of appearance of aerial mycelium before the beginning of spore formation
+Expression starts at 8-12 hours embryonic development, continues to increase until third larval instar, disappears in pupae and is present at a low level in adults. Expression in embryogenesis is correlated with the formation of a brush border within the alimentary canal. In third instar larvae, detected in segment A8 of the male genital disk (PubMed:22491943). First detected at stage 12 in the embryonic anterior and posterior midgut, and in the stomatogastric nervous system. Detected in trachea at stage 14. Widely expressed in stage 16 in embryos (PubMed:25659376)
+Isoform Alpha is ubiquitously expressed in fetal tissues. Isoform Beta and isoform Delta have more limited expression patterns, with highest levels detected in fetal spleen and fetal liver, respectively. Isoform Gamma and isoform Theta are weakly detected in fetal kidney
+After birth, expression in the organ of Corti increases about 10-fold by postnatal day 5 (P5) and remains at constant levels thereafter
+Isoform 1 is expressed both in juvenile and adult with highest levels in day 42 sac fry. Isoform 2 is only expressed in adult (at protein level)
+Temporally and spatially restricted during embryogenesis. At 10.5 dpc, expressed in the branchial arches, nasal processes, limbs, somites and dorsal root ganglia. At 11.5 dpc, expression persists at these sites in addition to the eye and fore-, mid- and hindbrain. By 12.5 dpc, expressed in the interdigital mesenchyme of the limbs. At 13.5 dpc, expression in the limbs flanks the digits and also appears in a subset of tendons in the hind- and forelimbs
+Present already at 9.0 dpc. At 10.5 dpc, expressed throughout the embryo. At 12.5 dpc, higher levels in the developing lung, liver and brain compared to other tissues. In the postnatal day 7 brain, high levels in the Purkinje cell layer of the cerebellum and in the hippocampal areas of the dentate gyrus and CA1, CA2 and CA3 pyramidal cells
+In seedlings, predominantly expressed in cotyledons. Restricted to the cotyledons and primary leaves
+First detected at the end of gastrulation in the anterior neuroectoderm. Expression increases in the developing brain during somitogenesis but has gone by 36 hours. Expression in the floor plate begins at the 10 somite stage and persists at 72 hours
+Expressed throughout development; pupae have very low levels of expression, in contrast to larvae
+During oogenesis and spermatogenesis
+Not detected at 7 dpc, weakly at 11 dpc and strongly at 15 dpc and 17 dpc. Expression covers the entire neural tube at 9.5 dpc, decreases at 10.5 dpc and becomes detectable only in the lumbar to tail regions at 11.5 dpc. In the somites, expression begins at 10.5 dpc to become up-regulated all along the rostrocaudal trunk axis at 11.5 dpc. In craniofacial territories, expression is first detected at 11.5 dpc in restricted areas of the nose, the maxillar mandibular and second branchial arch anlagen. At 11.5 dpc, predominantly expressed in restricted areas of the nose, dorsally to the eye and in the caudal pharyngeal region. Highly expressed at early stages of neuromuscular junction assembly (14.5 dpc) and gradually decreases as development proceeds, being more than about 4-fold less expressed in 19.5 dpc
+At 9.5 and 10.5 dpc, weak but general expression in the intersomitic mesenchyme. Higher levels of expression in the intersomitic vessels and other developing small and large blood vessels. Expressed in the notochord and the roof and floor plates of the neural tube. Expressed along rhombomeres 2 and 4, as well as pharyngeal arches 1 and 2, possibly in neural crest cells. No expression in the somites. At 14.5 dpc, predominantly expressed in all vessels, capillaries (at protein level), arteries and veins. Strong vascular expression observed in neural tissue, skeletal muscle, skin, kidney, liver, and along the gastrointestinal tract. Nonvascular expression detected in heart myocardium, lung and kidney mesenchyme (at protein level). During postnatal vascular development, expression shifts from capillary and venous vessels to arteries, from endothelial cells to vascular smooth muscle cells
+Expressed in the developing eye and brain. Expression in the retina peaks at fetal days 51-60. At 6-week old, in the retina, is predominantly detected in the neural layer (at protein level). At 8- and 10-week old, in the retina, the expression is strongest in the inner and middle layer of the neural part (at protein level)
+Found in the dry embryo (at protein level). Maximum level of expression 22 hours after start of seed imbibition
+Weakly expressed in the brain at 14 dpc (at protein level) (PubMed:21912965). Expressed in the brain at 14 dpc (PubMed:21912965)
+In the developing embryo, first expressed in the mesoderm at day 7.5. Expressed in the pharyngeal endoderm and the mesodermal cores of the pharyngeal arches at 8.5 dpc. At day 9.5, primarily expressed in the head region, specifically the mesenchyme and epithelium of the pharyngeal region and the otic vesicle epithelium. By day 12.5, expression is still observed in the latter as well as in the tongue mesenchyme, tooth buds and branching lung epithelium
+Found in larva, but not in the adult parasite
+Detected in embryos from 12.5 days post coitum (dpc) onwards. Expressed in all four ventricles of the developing brain, with highest expression in the outer ventricular layer. Also found in the limb buds at 12.5 dpc. Detected in the brain (hippocampus) and retina at postnatal day 1. Expression in the retina is localized to the ganglion cell layer. At postnatal day 10, expression remains strong in the hippocampus where it localizes to the four CA fields and the dentate gyrus
+Expressed at stage 19 before sexual differentiation, at stage 25 when the genital ridges are forming and also at stage 31 when sexual differentiation is beginning. Also expressed from stage 25 in the Wolffian ducts. More abundant in ZZ (male) than ZW (female) gonads
+The protein is expressed in oocytes as they develop. After fertilization, the level of expression remains high over the rapid cleavage stages, then decreases during the mid-blastula transition to a low level which is maintained throughout the later developmental stages
+Low expression during growth. Mainly expressed after 8-10 hours of starvation when cells are aggregating and in the multicellular stage
+In neonatal mouse cochlea, weak levels of expression in both hair cells and supporting cells (at protein level). In the cochlea of six day old mice, expression is restricted to hair cell sterocilia (at protein level)
+Early in development, at 9 dpc to 11 dpc, it is found most prominently in the heart myocardium surrounding the endocardium. Later, it becomes more widely distributed, most often in the mesenchyme surrounding developing vessels, in close association with endothelial cells
+In developing pollen grains, expressed in the vegetative nuclei at the early binucleate stage and during the second pollen mitosis. Expression significantly decreases at the late trinucleate developmental stage. Not expressed in released mature pollen grains, germinating pollen grains and pollen tubes
+Simultaneously present in aleurone and endosperm between 20 and 30 days postanthesis. Accumulates in the developing grain and is stored in its active form in the mature grain. Also found in the roots and shoots of the growing seedling
+Expressed in fetal liver and kidney
+Highest levels between 5 days and 1 month of age. Thereafter, the expression of declined to a level of approx. 35% of maximum, and remained constant throughout the rest of the observation period
+Highly expressed in developing bones during embryogenesis and expression increases as osteoblast precursor cells differentiate into mature osteoblasts
+First detected at 12.5 hours post-fertilization (hpf) in dorsal presomitic mesoderm and in the neural keel, extending to the ventral somitic mesoderm during tail budding. At 16-19 hpf, restricted to the posterior end of the somitic mesoderm. Also expressed in the developing pectoral fins from 34 hpf, with progressive localization to the periphery
+At stage 11, expressed in the surface ectoderm surrounding the optic vesicle. At stage 15, expressed in anterior/nasal side of the early retina. At stage 26, during the peak period of ganglion cell genesis, highly expressed in the nasal retina and the lens ectoderm
+Expressed throughout growth and development and shows increased levels during the post aggregation stages. Abundantly expressed when fruiting body formation is close to completion
+Detected in testis 25 days after birth and thereafter
+Expressed at high levels in embryonic nerve tissues, such as the brain, eyes, and spinal cord
+Expressed in the olfactory bulb, telencephalon, hypothalamus, midbrain tegmentum, retina, hindbrain and the spinal cord. Expressed in GnRH3 neurons within the olfactory epithelium and terminal nerve
+Expressed throughout development and in adults, with highest levels of expression during embryogenesis
+Highly expressed early in seed development and in 6-week-old senescent leaves
+Detected as early as 11 dpc. At 13 dpc detected mainly in the nervous system. At 16 dpc, detected in the brain, spinal cord, trigeminal, vestibular-cochlear, and spinal ganglia. In adults, expressed in spinal cord, and numerous brain regions
+In mid-small intestine, very low levels at birth. Expression levels rise dramatically during the weaning period (P17-P22) and remain high into adulthood in conventionally raised but not germfree animals
+Expressed in all 3 larval instars and to a very low extent in adults, but not pupae or eggs
+Expressed at low levels at 20-25 weeks of gestation in fetal brain, lung, liver and kidney
+Ubiquitously expressed at 7.5 dpc. At 8.5 dpc, preferential expression in yolk sac blood islands. Progressive down-regulation in maturing primitive red cells between 10.5 and 12.5 dpc. High expression in fetal liver at 12.5 dpc
+Expression in brain started at late 13.5 dpc and continued to adult (8W) with a peak around P10
+During the asexual blood stage, expressed in schizonts (PubMed:22817984). Expressed in gametocytes (PubMed:22817984). Expressed in ookinetes and oocyst early stages (PubMed:22817984). Expressed in sporozoites (PubMed:22817984, PubMed:32866196). Not expressed during the liver stage (PubMed:32866196)
+First detected in fourth-instar larvae and disappears abruptly in early pupae
+Expressed predominantly during the first 40 days of lactation, after which levels decrease sharply
+Expressed at a very low level in vegetative cells, induced by 4 hours, maximally expressed at the tight aggregate stage and through the remainder of development
+Expressed early in flower development (PubMed:20543029). In corollas, accumulates progressively during flower development, from buds to anthesis, with a peak at flower opening, but fades out in senescing flowers (PubMed:20543029, PubMed:21464473)
+Present in all interphase cells with a punctate pattern in the nucleus. Aligned along the metaphase plate in metaphase cells and becomes concentrated at the poles in anaphase cells (at protein level)
+Isoform 2 is expressed in testis from 30 days of age, with significantly increased levels by 60 days; this corresponds to the stage when haploid spermatids appear
+Expressed in the developing embryo (PubMed:15632077)
+It is synthesized during oogenesis and persists during early cleavage, levels drop before gastrulation and remain low until the tailbud stage, and then increase in the later stages
+Expressed ubiquitously during early stages of development. From bud stage onwards, the expression pattern becomes restricted to the axial structures and the developing Kupffer's vesicle
+This protein is detected in the nuclei of all cells in embryos and larvae but is not detected in the cells of metamorphosed juveniles
+Expressed both maternally and zygotically. Early embryos have high levels of expression, this drops off and zygotic expression begins at 3-6 hours embryos. Expression levels are low in larvae and medium in pupae and adults
+Highly expressed during senescence
+Observed throughout the embryo sac and in sporophytic tissues including the funiculus and the placenta
+In the embryo sac, confined to synergid cells (SCs) (PubMed:22872756). Observed in sporophytic tissues including the micropylar end of integuments and placenta (PubMed:22872756)
+Expressed at 10.5 dpc at diverse locations including the embryonic forebrain, otic vesicle, branchial arches, primitive gut, and genitourinary system. Transient expression in the ventral neural tube at 12.5 dpc. By 14.5 dpc, strong expression throughout the gastrointestinal tract was observed in the luminal tissues of the esophagus, stomach, duodenum, and intestines, as well as transient expression in the skin. Not expressed in kidney
+Up-regulated from late-maturation to mature dry seed. Up-regulated immediately after seed imbibition, reaching a maximum at 6 hours and decreasing therafter
+Expressed during bone development
+Levels increase in fruit peel during fruit maturation
+Expressed in developing siliques 3-13 days after pollination
+Expressed at high levels in the brain, spinal cord, eyes, muscle, lungs, vertebrae, and intestine and at lower levels in the heart and livers at 12.5 dpc. At later stages of embryogenesis (14.5 dpc, 16.5 dpc, and 18.5 dpc) high levels were found in the brain, retina, bone marrow, skin, intestine, lung epithelium and the epithelial layers lining the olfactory cavity and developing teeth and whiskers
+Expression is low at birth. Increases to adult levels after 5 weeks
+At 16 dpc and 18 dpc, widely expressed with higher expression levels in non-neural cells and hippocampus (at protein level)
+mRNA is detected from the 19th gestational week onwards at levels comparable with those of adult liver
+Expressed at least in P2 germline cell at 4-cell stage and up to 26-cell stage embryos (PubMed:11003841, PubMed:12110172). Expressed only at L4 stage during larval development and then accumulates in adults (PubMed:11003841)
+Produced during the late phase of lactation
+Expression dramatically drops soon after the onset of development and remains at a low level for the remainder of development
+Expressed in adult but not in embryo. Expressed in the placenta from early post-implantation (5.5 dpc) onwards. After 9.5 dpc expression declines
+Expressed throughout larval development and in adults
+Initially expressed during tip elongation and continues to accumulate into culmination
+Expressed in embryo at 15 dpc and strongly expressed in postmitotic neurons of the subplate, cortical plate, subventrical and marginal zones at 18 dpc (at protein level). Expressed in embryo at 7 dpc onwards
+High expression during late G2-S phases. During development, expression level peaks at 12-15 hr post-starvation, and falls thereafter
+Only expressed by three day-fed female ticks
+Expressed both maternally and zygotically. Expression levels remain constant during embryonic development, increasing at the swimming tadpole stage
+Predominantly expressed in immature xylem vessels, only in some cells just beside xylem vessels. Also present in various vascular cells of older part of the roots, near the location of emergence of the lateral roots
+Expression first detected in the cortical plate as early as 14 dpc, peaks in the middle neocortex at postnatal day 1 and then gradually decreases. At postnatal day 1, also expressed in the striatum, but not in the olfactory bulb
+Strongly induced during senescence
+Barely detectable during embryogenesis at control temperatures. Distributed throughout the cytoplasm of early developing myocytes at 24 hours post fertilization (hpf)
+Fully edited transcripts more abundant in the bloodstream form of T.brucei than in the procyclic forms
+Accumulates in early floral primordia and fades out in cells that will give rise to stamens and carpels
+Expressed at L4 larval stage and in adults. Expressed at low levels in embryos and between the L1 and L3 larval stages
+Present in cats older than about 3 months, and its level increases with age
+Expression starts in the late blastula (stage 8), increases during gastrulation and remains constant between neurula and larva stages
+Expression in the developing cerebral cortex increases during the course of fetal development and peaks around the late-mid fetal stage, concurrent with the onset of synaptogenesis in the cortical plate (PubMed:27830782)
+Detected in the organ of Corti as early as 6 days after birth; levels increase up to day 20, concomitant with the development of high sensitivity hearing
+Expressed at later stages of seed maturation
+First observed in a subset of undifferentiated epidermal cells, often by pair of neighboring cells. Later confined to small epidermal cells, including cells that have recently divided next to stomatal lineage cells. Also expressed in stomatal lineage cells, fading out progressively during meristemoid determination
+Expressed in vascular tissue of seedlings, leaves, root tips, inflorescence stems and flowers (PubMed:24963069). In pistils, detected in the ovary walls, styles, mature embryo sacs and developing embryos (PubMed:24963069). In pollen grains, mostly present in mature grains at anthesis and in germinated pollen tubes (PubMed:24963069)
+At 14 dpc expressed in mesenchymal tissue surrounding the cartilaginous anlage of immature bones, and in the future joint spaces. As endochondral ossification progresses, and the hypertrophic cartilage zone is replaced by mineralized bone, expression appears in the mineralizing portion of the bone. Expressed in mesoderm derived bones of the skull base and neural crest-derived endochondral bones such as the proximal mandible
+Hihly expressed in both chalazal and peripheral endosperm during embryo development (from pre-globular to heart stage)
+Expressed at pupal and adult stages (at protein level)
+Detected throughout the embryo at 10.5 dpc; higher expression is found at 13.5 dpc in neural mesenchymal cells, skeletal muscle of the tongue, and epithelial cells of the colon and small intestine; at 15.5 dpc, expression in epithelial cells of lung, kidney, bladder, and colon is also detected
+First expressed widely in 200- to 260-minute-old embryo, except in hyp-7 cells (PubMed:10993673). Expression becomes more restricted to the anterior, ventral, and posterior part in the comma stage embryo (PubMed:10993673). Expressed in all neurons and some other tissues of the larva (PubMed:10993673). Expressed in primary vulval cells during the L4 larval stage (PubMed:12736204)
+Present in all developmental stages
+Abundant in hyphae
+Expressed at all stages of embryonic development with highest levels in later developmental stages
+Preferentially expressed in vascular tissues such as the central cylinder, cotyledons of mature embryos and steles in seedlings roots (PubMed:21558309). Accumulates also in emerging root primordia (PubMed:21558309). In aerial parts, a weak expression is observed where new xylem tissues are formed, including the vasculature of young leaves, stem nodes and flower tori (PubMed:21558309)
+In regenerating livers, it showed maximal expression 48 hours after hepatectomy, expression remaining elevated up to 2 weeks after liver removal
+In early embryos expression is very low, expression increases during embryogenesis. Also expressed in larvae and pupae
+Expression starts at the time of epididymal maturation
+Expressed in prestalk pstA and pstO cells in the slug stage. Preferentially restricted to pstO cells during culmination. Expression in the prestalk cells is reduced in dmtA-null cells. Expression is gbfA-dependent
+Isoform 1 is expressed in the cortex at 15.5 dpc. Isoform 2 is not detected in the cortex at 15.5 dpc (at protein level)
+Expressed during excystation, the differentiation from cyst to trophozoite (at protein level) (PubMed:19861170). Expressed in trophozoites (at protein level) (PubMed:24658679, PubMed:19733174, PubMed:24147113, PubMed:24728194, PubMed:28932813, PubMed:22452640, PubMed:23058231, PubMed:21135098). Highly expressed during encystation stage, the differentiation from trophozoite to cyst (at protein level) (PubMed:24658679, PubMed:19733174, PubMed:24147113, PubMed:22452640). Expressed in feces extracted cysts (at protein level) (PubMed:19861170, PubMed:23058231). Expression in them is significantly lower than in trophozoites (at protein level) (PubMed:23058231). Constitutively expressed throughout the life cycle (PubMed:16368691)
+Barely detectable in 6 days after-germination (DAG) seedlings, but highly expressed in 14 DAG seedlings
+In seedlings, present in the root, hypocotyl and cotyledon veins. In roots, excluded from the root tip, otherwise observed in the endodermis, pericycles and vascular bundles, except vessels. Expressed in the root differentiation zone, especially during root hair formation. In mature plants, mostly detected in vascular bundles, but not in vessel cells
+Expression detected in mesenchymal cells of postimplantation embryos, particularly in the regions where the lymphatic vessels undergo sprouting from embryonic veins, such as the perimetanephric, axillary and jugular regions, and in the developing mesenterium. Also detected between vertebral corpuscles, in lung mesenchyme, in neck region and in developing forehead. Not detected in the blood islands of the yolk sac
+Accumulates during developmental leaf senescence
+Expressed in vulva cell precursors (VPC) P5.p, P6.p and P7.p, and their descendants during L3 and L4 larval stages
+Preferentially expressed in germinating seedlings
+Levels are detected just prior to the developmental commitment to budding growth
+Highly expressed in fast-growing organs and dividing cells
+During cell division, levels are elevated between hours 0 at the onset of division and 4 at mid-divison. After 5 hours, when division is close to completion, levels decrease and stay low until hour 7
+Highly expressed in source leaves and at low levels in sink leaves
+Expressed both maternally and zygotically. Present throughout embryonic development, and in adults
+In young seedlings, expressed in the shoot apical meristem (SAM) and in root tips (PubMed:22897245). In inflorescence, detected in young floral buds, carpels and seeds (PubMed:22897245)
+Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed in both the airway epithelium of the forming lung as well as in the surrounding mesenchyme. By 16.5 dpc, expressed throughout the conducting airway epithelium, with highest expression in the distal alveolar regions. Also expressed in the endotheial cells of the pulmonary vasculature. During intestinal development, expressed in the mucosal layer but absent from the epithelium at 12.5 dpc. By 16.5 dpc, expressed in both the inner circular and outer longitudinal muscular layers of the intestine as well as in the epithelium of the intestine and developing stomach (PubMed:14516685). Expressed in 12.5 dpc midbrain dopaminergic neurons (PubMed:20175877)
+Expressed during hippocampal formation with high expression in the pyramidal cell layers
+Detected at hatching blastula, it remains at a certain level from the mesenchyme blastula to the pluteus stages
+Abundant in hindlimb and cardiac muscles throughout embryogenesis (at protein level)
+In developing spikelets, expressed in all floral organs from the premeiosis stage to the heading stage. Also present in the outer and inner epidermis and trichomes of the palea/lemma, lodicules, stigmas, and anthers. In anthers at the vacuolated pollen stage, expressed strongly in the epidermis but only weakly in the tapetum, endothecium, and connective tissue. In vegetative tissue, confinde to collar regions (between the leaf sheath and the leaf blade) and the base of shoots
+Barely detectable on the body surface of 8 and 15 day old fish. In 30 day old fish, when scale development has started, expression is high in patches of epithelial cell clusters and at the posterior margins of growing scales
+Detected in prenatal liver nuclear extracts (12.4-27 weeks estimated gestational age). Not detected in postnatal liver samples
+First detected in the neurula stage and then increased during late tadpole stage
+Expressed in embryos at 10.5-13 days post coitus (dpc), including developing ventral hypothalamus, Rathke's pouch and subventricular layers of the developing diencephalon (PubMed:1633105, PubMed:9090387). Expressed in the vomeronasal organ, olfactory epithelium, and vomeronasal nerve fibers at 14.5 to 16.5 dpc (PubMed:15470499). Expressed in various areas of the developing hypothalamus at 18.5 dpc, including the septal areas, the diagonal band of Broca (DBB), within the organum vasculosum lateralis terminalis (OVLT) region, in the paraventricular nucleus (PVN), in lateral areas of the hypothalamus (LH), in the arcuate nucleus (ARC), and in the dorsomedial hypothalamic nucleus (DMH) (PubMed:15470499). Also expressed in the developing pons from 14.5 dpc onwards, including the pontine and reticulotegmental nuclei (PubMed:17573818)
+Expressed in both sexes from the onset of the cellular blastoderm formation throughout development
+Expressed in embryos (PubMed:9247263, PubMed:23283987). Highly expressed in mid to late L3 stage larvae (PubMed:28135265). Expressed in adult animals (PubMed:20385102)
+Levels increase early during seed development, reach maximum 10 days after flowering and then decrease
+Expressed in all cell stages of spermatogenesis
+At 28 hr post-fertilization (hpf), expressed exclusively in the hair cells of the anterior and posterior maculae in the developing ear. At 4 days post-fertilization (dpf), expressed specifically in hair cells of the inner ear and lateral line organ
+Interaction with SpoIIAB inhibits sigma F activity throughout the cell before the formation of the asymmetric septum; after septation the interaction is confined to the mother cell, and sigma F activity is released in the prespore
+Expressed at embryonic stages 10 to 11 in the nondifferentiated mesodermal cells at the venous and arterial poles, as well as cells of the dorsal coelomic wall and ruptured mesocardium (at protein level) (PubMed:21403123). Expressed by all myocardial cells at embryonic stages 10 to 11 (at protein level) (PubMed:21403123)
+In cultured hippocampal neurons, expression levels of both isoform 1 and isoform 2 increases with in vitro development, with prominent expression coinciding with the completion of synaptogenesis and persisting through mature stages
+Differentially expressed in fetal lung with highest levels at gestational days 14 to 16
+At embryonic day 8.5 dpc, expressed in the developing heart with the strongest expression occurring in the inflow tract, especially in the left horn. At 9.5 dpc, expression is still detectable in the atria and ventricles, albeit at lower levels whereas strong expression remains in the inflow tract. From 10 dpc onwards, it is also expressed at low levels in somites, particularly in the myotome region, that gives rise to skeletal muscle. At 10.5 dpc, cardiac expression is no longer restricted to the inflow tract. At 14.5 dpc, it is expressed in the entire myocardium
+Present at low levels in vegetative cells, peaks at roughly 5 hours and decrease by 10 hours. There is another peak of production at 12.5 hours, and a slight increase beginning at 20 hours (at protein level)
+Embryonic, larval, and pupal stages. Only expressed in female adults
+Expressed in the mesoderm of the cardiac crescent at 9.5 dpc. Expressed in cardiac myocytes of the sinoatrial compartment and some restricted areas of the dorsal part of the ventricle chambers at 10.5 dpc and 12.5 dpc. Expressed in branchial arches, myotome and in a posterior domain in the limb at 10.5 dpc. Expressed in the heart, mainly in the compact layer myocardium, peridigital mesenchyme, the somites of the tail bud, the smooth muscle cells of the trachea and the developing bronchial tree, the smooth muscle cells lining the digestive tract, the dorsal root ganglia and the pancreas anlage at 13.5 dpc (at protein level). Expressed in the sinoatrial compartment and some restricted areas in the dorsal part of the ventricle at 9.5 dpc, 10.5 dpc and 11.5 dpc. At 12.5 dpc, expression was observed in the ventral half of the ventricle where it was limited to the subepicardial compact layer
+Detected in the embryo and early planula larva stage. It disappears when larvae transform to the polyp stage after 2-3 days. Strong expression is seen in the gonozoid and in all stages of medusa bud development
+Expressed in G2/M phase. Not detected in quiescent cells
+Expressed in embryonic heart at 11.5 and 13.5 dpc (PubMed:25313962). Expressed in MyoD-expressing myoblasts at 11.5 dpc (at protein level) (PubMed:25217815). Expressed in the early cardiac mesoderm at 7 dpc (PubMed:19658189). Expressed in the cardiac crescent at 8 dpc (PubMed:19658189). Expressed in the developing heart and somites from 9.5 to 12.5 dpc (PubMed:19658189, PubMed:25313962, PubMed:25217815). Expressed in the lens, otic vesicle, heart and weakly in the mesodermal core of the first and second branchial arches at 10.5 dpc (PubMed:25217815). Expressed in all appendicular muscle masses at the forelimb and hindlimb levels and in developing head muscles at 11.5 dpc (PubMed:25217815). Expressed in appendicular muscle masses, diaphragm muscle and developing head muscles at 12.5 dpc (PubMed:25217815)
+Primarily detected in the central nervous system at 10.5 dpc, in the ventral part of the neural tube including the ventral spinal cord, the ventral part of the mesencephalon, the mammillary and the hypothalamic regions, the optic area and the zona limitans intrathalamica (PubMed:11744384). Expressed by the V3 interneurons placed between the floor plate and the motorneurons all along the spinal cord axis (PubMed:11744384). In late embryogenesis, expressed mainly in ventral neural structures of the developing brain, including the mammillary, tuberalis regions of the hypothalamus and the preoptic area (PubMed:11744384). Starting from 12.5 dpc, also strongly expressed in the neural area that gives rise to the dorsal thalamus (PubMed:11744384). In the retina, expression starts at 11.5 dpc and is enhanced at 12.5, 14.5 and 16.5 dpc (PubMed:11744384). Expressed in the subapical region of the neuroepithelial layer of the retina at 17.5 dpc (PubMed:23001562). In postnatal stages, abundant expression in photoreceptors and also found in the inner nuclear layer and iris (PubMed:11744384)
+Expression first detected at 14 dpc, expression is enhanced at 15 and 16 dpc during active proliferation of epidermal cells, decreases after birth, but is maintained in adult skin (PubMed:14684155). Detected in the skin basal cells at 16 dpc, it was observed in upper layers after birth (at protein level) (PubMed:14684155)
+Present from late embryogenesis onwards
+Expression peaks at the climax of metamorphosis
+Not detected until cycle 14 of embryogenesis when the cleavage cycles are completed (at protein level) (PubMed:12919679). Expression levels peak 15-30 min after cellularization and decrease during late cellularization and gastrulation (at protein level) (PubMed:12919679). Expressed until stage 9 in an area of dorsal cells that are probably the amnioserosa anlage (at protein level) (PubMed:12919679). At cycle 13, uniform expression throughout the cortex with expression levels increasing during stage 14 (PubMed:2478402). During cellularization expression localizes dorsally and posteriorly (PubMed:2478402). During gastrulation expression persists in dorsal regions of the embryo and by germ band extension expression is concentrated anterior to the amnioproctodeal invagination and posterior to the forming cephalic furrow (PubMed:2478402)
+Low levels in the globular stage, but accumulates during early heart stage of embryogenesis and remains expressed during all later embryogenesis stages
+Cell-cycle regulated. Down-regulated when cells enter M phase. Expression increases again when cells enter S phase of the next cell cycle
+Expressed both maternally and zygotically. Detected in every cell of early cleavage embryos through to gastrulae. From around 6 hours post-fertilization (hpf) through to early somitogenesis, expressed along the entire anterior to posterior length of the gastrula. At 19 hpf, expression is up-regulated in the developing tail bud and it becomes restricted to the tail bud by 24 hpf. By 40 hpf, expression is further restricted within the tail bud, possibly to the developing vertebrae. No expression at 72 hpf
+Expressed in early embryos and germ cells
+Expressed during the late stage of conidial (dormant spores) differentiation. It is greatly reduced or absent in the aconidial mutants fd, acon-2 and acon-3
+Expressed in brain during neonatal period. Not detected in adult brain (at protein level)
+Highly expressed after birth, reaching a maximum at the postnatal day 7, and declines thereafter in the cerebrum, whereas it increases in the cerebellum to adulthood
+Expression increases shortly before the onset of abscission
+At 9.5 dpc, expressed in the chorionic plate. From 10.5 to at least 11.5 dpc, is also expressed in the trophoblasts of the labyrinthine layer
+Detected at the oocyte stage. Expressed throughout the embryo in early embryogenesis, with particularly robust expression in the brain and posterior tail regions at 26 hpf. At 48 hpf, strongly expressed in discrete areas of the brain, the mandibular cartilage and branchial arches, the otic vesicle and developing pectoral fins
+Expressed during a specific period of late oogenesis, from late meiotic pachytene to late diakinesis. Repressed prior to terminal oocyte differentiation
+Highly expressed in actively dividing cells of root pericycle and suspension cell culture. Expressed in the G1/S phases and reaches a peak at the G2 phase
+Expressed at high levels at 20.5 dpc. Expressed at lower levels at P2 and P6 and in adults (at protein level)
+Predominantly found in the prestalk of the slug
+Uniquely and highly expressed in pre-implantation embryos and pluripotent stem cells, but sharply down-regulated following differentiation
+Expression increases from prepupal to adult stages
+Expressed at the 1.5-fold stage of embryogenesis and by the 3-fold stage, in all cells of the gut (PubMed:14573471). Expressed in nine cells in the posterior bulb of the pharynx from the 3-fold stage (PubMed:14573471). Expressed in the intestine at all stages of development (PubMed:14573471)
+In brain, shows increasing expression levels from postnatal day 7 onwards reaching peak levels by postnatal day 21 (at protein level) (PubMed:12691844). Expression is seen very early in embryogenesis, 9.5 dpc in all parts of the embryo (PubMed:7633444). Mid-gestation embryos (14.5 dpc) show high expression in all neural tissues such as telencephalon, retina and spinal cord (PubMed:7633444). In the 16.5 day old embryo high expression is seen in the neural tissues, like telencephalon and mesencephalon and in the non-neural tissues, such as muscle tissues in the tongue and around the ribs (PubMed:7633444)
+Detected 4 hours after fertilization with maximum levels seen in 6 hours embryos. Expression then declines during gastrulation (6-10 hours), but is still detectable in 24 and 30 hours embryos. The spatial distribution also varies during embryogenesis: at the beginning, expression is localized in deep cells and is absent from the enveloping layer. The pattern then becomes asymmetric, restricting to the forming embryonic shield. By the shield stage, it is highly localized in the axial hypoblast. As gastrulation proceeds, expression continues in the involuting cells, extending from the margin towards the anterior
+Expressed in Leydig cells during fetal testicular development, especially during the second semester. Germ cells expression is detected as early as 10 weeks of gestation
+In flowers, restricted to anthers
+In the larval primary lymph gland, expressed throughout the medullary and cortical zones (at protein level). Also detected in larval and embryo plasmatocytes (at protein level)
+The 80 kDa and 200 kDa forms were detected only during embryonic development. The 80 kDa form reaches a maximum of expression at 14 dpc/15 dpc and then decreases gradually. The 140 kDa form is already detected at 7 dpc. The 130 and 140 kDa forms reach their maximal expression at 20 dpc (at protein level)
+Transiently induced 3 days after seed imbibition (PubMed:8972604). Increases rapidly between 1 and 3 days after seed germination (PubMed:16813579)
+Levels are highest in the fimbria and ampulla at estrus and on day 1 of pregnancy, when gamete transport and fertilization occurs in the E2-dominated fallopian tube. Levels decline significantly on day 2 and undergo a further significant reduction on day 3 of pregnancy coincident with transport of the embryo from the oviduct to the uterus, a reproductive stage associated with rising progesterone levels
+Limited spatially to the medical ganglionic eminence and the mesenchyme surrounding the oral cavity and temporally from middle embryonic to early postnatal development
+Expressed during the middle and late stages of the chlamydial developmental cycle including the stage of the formation of infectious elementary bodies
+Isoforms containing exon 3 (isoform 9 and isoform 10) are expressed in adults. Isoforms containing exon 6a1 (isoforms 1 and 2) are expressed at all developmental stages. Isoforms containing exon 6a2 (isoforms 3 and 4) are weakly expressed in embryos and larvae and very weakly in adults. Isoforms containing exon 6b1 (isoforms 5, 6, 9 and 10) are weakly expressed in larva and increase during metamorphosis. Isoforms containing exon 6b2 (isoforms 7 and 8) are weakly expressed in embryos and larvae and at a higher level in adults
+Regulated in a cell-type-specific manner with high levels in WO-1 opaque cells and undetectable levels in WO-1 white cells
+Expressed during flower development until 15 days after flowering (PubMed:16552590). In pollen development, expression increases gradually from meiosis/tetrad stage to mature pollen stage, with the highest expression in the latter (PubMed:31671177)
+Produced mainly in encysting cells
+Expressed in vegetative and developing cells
+Not expressed during vegetative growth. Expressed from around 4 hours following the induction of starvation. Expression peaks around 14 hours (first finger/slug stage), and drops around 18 hours (Mexican hat stage). Expressed at high levels in prestalk cells. Also expressed in spores that have risen to the top of the fruiting body and undergone encapsulation
+up-regulated during granulocytic differentiation
+Expressed in emerging young seedlings from 3 to 4 days after seed imbibition
+Expressed in UV1 uterine cells in late L4 larval stage
+Hardly expressed in pro-B and pre-B cells. Moderately expressed in immature B-cells, mature B-cells and plasma cells. Highly expressed in transitional B-cells
+Expressed in the shoot apical meristem (SAM) during the vegetative phase and the floral transition. After floral transition, expressed in apical meristem (AM), inflorescence meristem (IM) and floral primordia
+Appears transiently during greening of etiolated seedlings and disappears before chloroplast development is completed
+Expressed in fetal heart
+Expression increases rapidly at 5 hours and peaks at 7 hours after onset of sporulation
+Expressed at a fairly constant level throughout embryonic development
+Expressed from precellular blastoderm stages. Expressed in the CNS midline, neuroectoderm, supraoesophogal ganglion and trachea from embryonic stage 9. Expressed in the tracheal placodes from stage 10. Expressed in a subset of posterior glia in the brain and a subset of anterior neurons at stage 11. Expressed in CNS midline cells and segmental ectodermal stripes during stages 12 and 13 and in dorsally positioned midline glia and ventrally positioned midline neurons from stage 14. Expressed in posterior and anterior glia and neurons at stage 15
+Expression is high during the larval stage, predominantly in the feeding and wandering larvae
+Detectable at postnatal day 24 (P24) and its expression is increased at day P30 and P35
+Expressed throughout all stages of embryonic and larval development
+Appears at embryonic day 16 and persists in early postnatal life and in the brains of adults (at protein level)
+Expressed during the G2-M phases of the cell cycle
+Expressed weakly in the inner retina at postnatal day 5 (P5), with expression becoming abundant in retinal ganglion cells at P8 (PubMed:30936473). Expressed throughout the retinal sublaminae layers, with abundant expression in the ganglion cell layer and nerve fiber layer at P12 (PubMed:30936473). Expressed in ganglion cells in the optic tracts, superior colliculus and lateral geniculate nucleus of the brain at P28 (PubMed:30936473). Expressed around the base of hair follicles in the dorsal ear skin, in the vibrissal nose pad, and weakly expressed below the epidermis in the vibrissal nose pad at P8 (PubMed:31607531)
+First expressed in retinal lens fiber cells during elongation and differentiation, becoming localized to the cytoplasm as fiber cells mature and the beaded filament network forms at 3 weeks of age
+Expressed both maternally and zygotically. Expressed during oogenesis and embryogenesis. Isoform 3 and isoform 4 are expressed in the germarium at stage 2. Isoform 4 is expressed in the nurse cells at stage 6 until the nurse cells degenerate. Isoform 3 is expressed in the follicle cells at stage 8, in the anterior-dorsal follicles cells from stage 10 until the follicles degenerate. Isoform 2 and isoform 3 are expressed in late stage 12 embryos, onwards. Isoform 2 is expressed in tracheal cells and in lateral glial cells within the CNS in late stage 16 embryos
+During embryogenesis detected at 10 dpc and expression gradually increases thereafter. Expressed mainly in the nervous system, including brain, spinal cord, trigeminal ganglion, and retina. Within the CNS detected in the mantle zone, but not in the ventricular zone. Detected at postnatal day 23 with highest levels in mesencephalon. Also expressed in developing bone and gut
+Expressed at detectable levels throughout later stages of mouse development such as 12 dpc, 14 dpc, 16 dpc and 18 dpc
+Transiently but abundantly expressed by ameloblasts during tooth development. Amelogenin is the predominant protein in developing dental enamel
+Expressed around 6 hours after fertilization. Expression increases in retort-form ookinetes and continues in mature ookinetes (PubMed:35947628). Not expressed in male or female gametocytes (PubMed:35947628)
+During embryogenesis, present only in the embryo from the torpedo stage onward. During germination, first restricted to the radicle to later become more pronounced in the root tip. Expressed in hypocotyl and cotyledons 5 days after imbibition
+In the embryo, abundant at 7.5 dpc and 8.5 dpc with higher levels at 9.5 dpc, 10.5 dpc and 11.5 dpc. Expression is low during the first two weeks after birth, increases during the third week and remains elevated in 4-week-old and adult mice. During spermatogenesis, expressed in spermatocytes mainly from zygotene to meiotic metaphase divisions and increases post-meiotically in round spermatids. Expression decreases in stage IV spermatids
+Expressed in developing embryos and adults
+Expression begins at postnatal day 20 (P20) and reaches a mximum at P25 in the testis (at protein level)
+Not detectable during early stages of embryogenesis. Detected at low levels at 14.5 dpc and 15.5 dpc. Highly expressed at 17.5 dpc
+Expressed maximally early in embryogenesis, and in late larval development
+Expression increases with age in neutrophils of an individual foal aged between 2 to 56 days (PubMed:22197007). Expression in neutrophils of a foal at age 1 day, another different foal at age 56 days, and of an adult horse is constitutive at a very low level (PubMed:19819162)
+Widely expressed throughout embryonic development, with some cells showing increased levels (at protein level). Such an increased level is observed in stage 11 in the epidermal cells immediately flanking the amnioserosa. This increase is particularly pronounced in stage 14 embryos around the time of dorsal closure initiation. Dorsal epidermal cells in the first row of cells adjacent to the amnioserosa show increased expression levels relative to the rest of the epidermis, with at least two cells flanking each segment border having particularly high levels. During dorsal closure, accumulates in the cells of the leading edge (at protein level). Expression is also higher in the abdominal segments than in the thorax, but in later embryos increased RNA levels are seen in the thorax and in more ventrally located epidermal cells flanking the segment borders. Following the completion of dorsal closure, high expression levels were detected in the dorsal vessel, in the central nervous system and in the epidermal cells at 3 thoracic muscle attachment sites in the epidermis. At the end of embryogenesis, elevated transcript levels are seen in muscle attachment sites throughout the epidermis
+Expressed at the earliest stage of spermiogenesis
+Protein levels peak in S phase and are lowest during M phase (at protein level)
+Observed exclusively in the late syncytial and cellular blastoderm stages of development. Transcripts are first detected during nuclear division cycle 11. They reach a strong peak at cycle 14 and from then on gradually decline until they are no longer detectable at the end of cellularization
+Detectable from 9.5 dpc
+Expressed at low levels during early embryonic stages, its expression increases later and reaches the highest level during late stages of embryogenesis. Subsequently, its levels are reduced during larval stages and increase during pupal stages
+Expressed at higher levels in fetal liver than in adult liver
+Expressed at higher levels in fetal brain than in adult brain
+Expressed at similar levels in adult and fetal brain
+Expressed at high levels during odontogenesis
+During kidney development, expressed at 10.5 dpc in the mesonephric tubules, and at 12.5 dpc strongly expressed in the comma shaped bodies and surrounding ureter stalk. In 14.5 dpc kidney, expressed in the S-shaped bodies. In the developing nervous system, expressed in the presumptive hindbrain and the ventral part of the neural tube from 8.0 dpc onwards. At 9.5 dpc, expression is additionally detected in the mesonephros and the optic vesicle. 10 dpc expression is found in the second and third branchial cleft, in the eye, the ventral neural tube and specific rhombomeres and prosomers. 10.5 dpc brain shows specific expression in the basal and alar plate. In developing eye, expressed at 9.0 dpc in the optic placode, and at 9.5 dpc in the optic vesicle. By 10.5 dpc, expression found in the lens vesicle and the inner layer of the invaginating optic vesicle. Strong expression at 14.5 dpc in the anterior lens epithelium, decreasing thereafter. Expression also found in the prospective neural retina. In developing limbs, expression found at 11.5 dpc in the shoulder and at the distal end of the cartilaginous condensation. At 12.5 dpc, expressed in the foot and hand paddle extending along the digital rays. Expressed, at 13.5 dpc and 14.5 dpc, in the forelimb and hindlimb where the interphalangeal joints will develop. Also expressed at 14.5 dpc between the sternal bands and where the ribs contact the sternum. In other developing structures, expression found at 11.5 dpc, in the maxillary and mandibular component of the first branchial arch, and later, in the loose mesenchyme surrounding cartilage and epithelia of the skull as well as in the whisker follicles. Also expressed in developing teeth, with the highest levels at 15.5 dpc and 16.5 dpc in the mesenchyme and the dental epithelium of the developing molars. Expressed in development smooth muscle surrounding the esophagus at 11.5 dpc, the dorsal aorta and the ductus arteriosus at 14.5 dpc, and the ureter stalk at 15.5 dpc
+Expressed in auditory hair cells at P10 (at protein level)
+Expressed prior to the formation of distinct motor axon pathways and before the segregation of motor neurons into columns. Expression restricted to the medial subdivision of the median motor column (MMCm)
+Expression is cell-cycle regulated, and peaks at late G2 to early G1 phase (at protein level)
+Maternally expressed. First detected in Kupffer's vesicle of seven somite embryos and the lateral mesoderm of 11 somite embryos. By 24 to 30 hours post-fertilization (hpf), expression becomes widespread within the central nervous system and the pronephros and parallels the development of multiciliated cells. During later stages of larval development (54 hpf), expression continues throughout the pronephros and intensifies in the olfactory placode and lateral line organs
+Induced in imbibing seeds prior to germination and down-regulated in elongating seedlings and senescing leaf petioles
+Highest expression in third-instar larvae and prepupae
+First expressed at the neurula stage
+Expressed 12 hours post-fertilization (hpf), concomitantly with the appearance of the optic vesicles. At 18-20 hpf expressed in presumptive neural retina. At 24 hpf when the lens are formed, expression in the eye is restricted to the neural retina. At 48 hpf, after completion of the retinal differentiation, expression is restricted to the germinal cells at the margin of the retina and to paired parasagittal locations in the dorsal mesencephalon and rhombencephalon
+Expressed both maternally and zygotically. Expressed at a low level maternally with expression levels increasing rapidly after stage 9. Expression is maintained throughout development and in a range of adult tissues including the ovary and testis
+Expressed in embryos and larvae (PubMed:14559923). Expressed in an oscillating expression pattern during larval development, with low expression at the L2 stage, high expression at the L2/L3 transition and low expression at the L3 stage (PubMed:28933985)
+Detected in the pituitary gland from postnatal day 1 onwards (at protein level) (PubMed:24514953). Weakly expressed in embryonic lung at stages 11.5 dpc and 12.5 dpc (PubMed:11682631, PubMed:18535256). Seems to localize most strongly to the growing tips of bronchi at stage 13.5 dpc (PubMed:18535256). Highly expressed in developing lung at stages 16.5 dpc and 18.5 dpc, where it localizes to airway epithelia (PubMed:11682631, PubMed:12406855, PubMed:12175512, PubMed:24514953). During gestation, detected in the mammary gland at 6.5 days post coitum (dpc), but expression declines at 8.5 dpc and is absent at later stages (PubMed:12175512)
+Detected only in the generative cell of late bicellular pollen and not in early bicellular pollen
+Detected from postnatal day 15 onwards, with high levels of expression by postnatal day 28
+Expressed in the basal layer and a small number of cells in the spinous layer of the tongue at P20
+Expressed in the epidermis from 7.5 dpc, prior to onset of epithelial stratification
+Expressed in the epidermis from 9.5 dpc, after the onset of epithelial stratification but prior to terminal differentiation
+Senescing flowers
+First expressed at the beginning of gastrulation at about 100 minutes; reduces in the anterior of the embryo at about 260 minutes, but persists and increases in the posterior embryo (PubMed:11880358). Expressed in comma-stage embryo in P neuroblasts and the mother cells of V5 and Q neuroblasts (PubMed:28716930). During larval development, expressed in the tail tip cells in hermaphrodites and males, and asymmetrically in descendants of the T cell lineage (PubMed:11880358)
+Expressed in the midbrain, forebrain, optic vesicles and eyes of embryos at 10.5 dpc and a more pronounced expression is seen at 12.5 dpc
+Detected in embryo at 10.5 dpc
+Highest expression at vegetative and pre-aggregation stages
+In flowers, expressed only in developing ovules (e.g. in egg cells)
+Detected at postnatal day 8 in sciatic nerve at the paranodes and the juxtaparanodal region. Is progressively translocated to the adjacent juxtaparanodal region until it becomes completely absent from the paranodes in the adult
+Highly expressed from 6.5 dpc in embryo plus deciduum. Faintly detectable at 11.5 dpc and 13.5 dpc in placenta. Not detected at 8.5 dpc, 11.5 dpc and 13.5 dpc in embryo proper. Expressed at 4.0 dpc in uterus
+Expressed during the transition between the late exponential and stationary growth phases, coincident with maximal glycogen accumulation
+Expressed in neonatal brain and in day 10 and 13 embryo
+Expressed at a low level at early stages. Expression increases during gastrulation, reaches maximum levels by the middle of neurulation, and slightly decreases during later development
+Expression starts between 10 and 12 hours post fecondation and is highest between 2 and 3 days after fertilization
+In testis, highly expressed from 14.5 days post coitum (dpc) until the day of birth, with levels falling after 10 days post partum (dpp) but peaking again at 28 dpp
+Expressed throughout development but most strongly in embryos and the L4 larvae stage
+Expressed in the developing brain at 12.5 dpc. At 14.5 dpc, becomes enriched in the ventricular zone and later, restricted to the progenitor population as cortical neurogenesis peaks. At this stage, not detected in the subventricular zone/intermediate zone (SVZ/IZ). At later stages, detected in the neurons of the cortical plate and in stem cells near the ventricular surface
+First expressed at 14 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 17. Also expressed in the developing hindgut, except in the most distal portion. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf
+First detected at the late gastrulation stage (9 hpf). Strongly expressed in distinct domains in the neural plate at the 3-somite stage. First expressed in the epiphysis at around 14 hpf
+Widely expressed in epidermal cells, gland cells and in amphid sheath cells throughout development, but not in muscle cells and neurons
+In the developing eye, already detected at 10.5 dpc. Expression increases from 12.5 though 18.5 dpc in all retinal cells (at protein level). At P1, expressed in a small number of cells at the level of the ganglion cell layer and in the inner edge of the ventricular zone of the retina. The number of expressing cells increases and, by P8 to P11, entirely occupies the ganglion cell layer and inner nuclear layer. At that stage, not detected in the photoreceptor cell bodies of the outer nuclear layer. At P21, expressed in all nuclear layers of the retina, including cones (at protein level)
+Accumulates to high levels in pollen grains, tapetal cells, and middle-layer cells of the anther wall. Also detected at high levels in connective tissue cells and the connective vascular element at the unicellular- to-bicellular pollen grain stages. At the tricellular pollen grain stage, confined to the cells of connective vascular elements
+First detected at 16.5 dpc only in olfactory epithelium (OE) and the epithelium of the vomeronasal organ (VNO). At this stage, expression in OE is punctate and is restricted to only some of the sensory neurons. At birth and postnatally, expression in these organs extends to more neurons. At 3 weeks, expression shows a smooth gradation from high apical to low basal within the layer of mature olfactory sensory neurons of the olfactory epithelium
+Expressed in pstO cells
+Expressed at varying, but relatively high levels throughout development
+In the developing neocortex, expression is detected at embryonic day 12 (12 dpc) and peaks at 14 dpc. Then expression levels decrease until postnatal day 5 (P5) and increase again at least until P30
+In corollas, accumulates progressively during flower development, from buds to anthesis, but fades out in senescing flowers
+Expressed in the neuroepithelium of telencephalon, diencephalon and rhombencephalon at 11 dpc (PubMed:28453519)
+Expressed throughout postembryonic development and adulthood (at protein level) (PubMed:10049576). In young larvae (10 h posthatching), expressed in five rectal epithelial cells, three left-right pairs of neurons, and four to six bilateral pairs of body-wall muscle cells, in the posterior body region (at protein level) (PubMed:10049576). At the same developmental stage, also expressed in the pair of hermaphrodite-specific neurons (HSN), in the mid-body adjacent to the gonad (at protein level) (PubMed:10049576). In early larvae, expressed in the male tail, and in hermaphrodite Ll stage larvae (0-2.5 hr post-hatching) in the most posterior body region and the tail (PubMed:17574230, PubMed:8101474). Expressed in most if not all somatic cells in the male gonad, with the exception of the linker cell (LC) and distal tip cells (DTCs) and their progenitors (PubMed:20553900)
+In early stages of embryo development, expression low when MYCN expression is high. Later, when MYCN levels diminish, levels increase
+Preferentially expressed in cells competent for DNA transformation; that is 5-15% of the population (PubMed:11918817, PubMed:16009133, PubMed:17630974)
+Expressed throughout postembryonic life (PubMed:19686386). Expressed in hermaphrodites in the interneurons ADAL/R and PVT, the chemosensory neuron pairs ASI, ASK, PHA and PHB, the RMED, RMEV and RID motor neurons, the sensory neuron pair ADE, the PQR mechanosensory neuron and in the PVPL/R interneurons (PubMed:19686386, PubMed:23764289). Also expressed in rectal gland cells rectD and rectVL/R, and the intestino-rectal valve cells virL/R (PubMed:19686386). Expressed in both sexes in the head interneurons SAAV, SAAD, SIAV, AVB, AIM, RMG, and in the tail in the interneurons PVN, LUA, PVT, and the pair PVS and PVU (referred to as PVP left and right in the hermaphrodite) (PubMed:23143519, PubMed:23764289, PubMed:23972393). Expressed in male-specific ventral cord neurons CP7 and CP8, and PDC (PubMed:23143519). Expression from the AIM interneurons in males is involved in mate searching behavior (PubMed:23143519)
+Detected in embryonic large blood vessels at 11.5 dpc
+Expressed in subepidermal cells of anlagen regions, then in abaxial part of primordia and finally in differentiating organs. Levels decrease in differentiated organs. In embryo the expression starts during the transition between globular and heart stages in the cotyledon anlagen. From the heart stage, expression expands to abaxial domain of the cotyledon primordia and decrease as the embryo matures. In stamen, expression restricted to the abaxial region differentiating into the connective. In gynoecium, expressed in the abaxial cell layers differentiating into the valves
+First detected after 15 days of embryonic development, and highly expressed after 17 days, coinciding with stratification of epidermis
+Levels decline 3-fold between days 7.5 and 12.5 of gestation. At 7.5 dpc, expressed more strongly in extraembryonic tissues than in the embryo proper. Expressed in amnion, chorion, and ectoplacental cone. In the yolk sac, expressed more strongly in the mesoderm layer than the ectoderm. Expression fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc, expression is down-regulated and observed in the eye and the spinal cord
+Expressed throughout embryonic and larval development (PubMed:16899238). Expressed in most embryonic cells during hypodermal morphogenesis, and in Z1 and Z4 distal tip precursor cells, in distal tips cells during gonadal migration and in the gonandal primordium, which become vulval precursor cells, during larval development (PubMed:16899238). Also expressed in hypodermal precursor cells P11 and P12 and their daughter cells P11.a, P11.p, P12.a and P12.p, and in the SDQL and PVM neurons which are derived from the QL neuroblast (PubMed:16899238). During larval development, expressed in blast B cells and its descendants, the QL cell and in cells in the nerve ring (PubMed:16631156)
+Expressed in young proliferating tissues, such as root tips, meristems, young leaves and floral buds (PubMed:17616738). Also observed in the mature embryo sac of the female gametophyte (PubMed:17616738). In embryos, first observed at low levels very early in the proembryo, accumulates strongly in embryos with more than eight cells and remains at high levels until cell division ceased prior to dormancy (PubMed:17616738). In seedlings, concentrated at the developing apex in all root tips and later in the developing flowers of the inflorescence (PubMed:17616738)
+Detected at 10.5 dpc with highest expression in the developing central nervous system. After 16.5 dpc expression decreases and at two weeks after birth is restricted to the proliferating neuronal precursor cells in the external germinal layer of the cerebellum and subventricular migratory stream
+First detected in step 11 spermatids. Levels increase in subsequent steps to reach a maximum in late step 15 and early step 16. Levels decrease in late step 16
+Expressed throughout development. Embryonic expression is most prominent 8 to 12 hours after egg laying
+Expressed in developing seeds from 10 to 20 days after flowering (DAF)
+During seeds germination, detected in embryos. In vegetative tissues under iron-sufficient, restricted almost exclusively to vascular bundles of roots and leaves, and to the root exodermis. In response to iron deficiency, accumulates in all tissues of roots and leaves
+Expressed throughout early globular-staged embryos and during embryogenesis
+Transcribed from stage t4 of sporulation. Expressed in the mother cell compartment at the late stage of sporulation and localizes around forespores in a CotE, SafA and SpoIVD-dependent manner
+Present in the root maturation zone, and in lateral root primordia. Expressed in two parallel files that are probably xylem pole pericycle cells. In leaves, detected in files of cells parallel to the vasculature
+After 7 dpc it is expressed in mesoderm lying posterior of the future primordial head and heart. Between 7.5 and 9.5 dpc it is expressed in presomitic mesoderm, epithelial and differentiating somites and in lateral plate mesoderm. In the body of mid-gestation embryos it is restricted to loose undifferentiated mesenchyme
+Constitutively expressed in dendritic cells from day 3-8 in culture
+Expressed after the mid-blastula transition (PubMed:19164561). Expressed in Kupffer's vesicle (PubMed:19164561)
+Expressed early in preimplantation development, being already detected in eight-cell-stage embryos
+Present in aerial hyphae of sporulating cultures; it is probably directly underneath the rodlet layer formed by RdlA and RdlB (at protein level)
+In oocytes, highly expressed in primary growth (stage I) and cortical alveolus (stage II) oocytes. Also detected in Stage I and II oocytes but not in stage III oocytes (at protein level)
+In late 10 dpc weakly expressed in postmitotic neurons in the mantle layer of the developing nervous system (at protein level). Expression increased at 11-12 dpc (at protein level). At 15-16 dpc, as more specialized neurons and nonneural cells are formed, expression is more tissue specific (at protein level). Expression was highest in the neurites, moderate levels were observed in the migrating postmitotic neurons in the intermediate and neopallial layers (at protein level). In the diencephalon and other CNS regions, while the weakest level of expression was observed in the cell bodies (at protein level). In nonneural tissues, high levels of expression were found in the muscle walls of the intestine, the blood vessels and the dermis (at protein level)
+Expression is first detected at 15.5 dpc. Strongly expressed perinatally
+Essentially expressed during embryogenesis
+Expressed in 12-day-old mouse; no or barely detectable expression is found in adult tissues
+Expressed from stage 16 embryos
+Present in developing flowers, particularly in pistils
+First observed at 10.5 dpc in the primitive gut and in the developing lung bud. Expression in the gut persists through 16.5 dpc and remains restricted primarily to the epithelial lining of the esophagus, stomach and intestine. Expression in the lung is detected in the bronchial epithelium at 14.5 dpc and at 15.5 dpc. Expressed specifically in acinar cells during pancreatic development. Detected in skeletal muscle tissues beginning at 12.5 dpc, persisting throughout all embryonic stages examined although, in older embryos expression becomes severely reduced
+Strongly expressed in mature male and female strobili and in developing female strobili (PubMed:16203714). Present at lower levels in developing male strobili (PubMed:16203714)
+Expression in the brain shows variation throughout the seasonal sexual cycle; in the optic tectum-thalamus of females, expression levels are lower in early gonadal recrudescence (October) compared to other sexual stages. In males, expression is high in the olfactory bulbs in early gonadal recrudescence and low in the posterior brain in late gonadal recrudescence (January). Expression is higher in females than males in the telencephalon-preoptic region and posterior brain during late gonadal recrudescence, and in the olfactory bulbs and optic tectum-thalamus during the sexually mature (April), and post-spawning and sexually regressed (July) stages
+Expressed in leaves primordia and later confined to trichomes
+Expression decreases after the onset of development
+Expressed in larval stages L2 and L3 and increased expression during dauer stage (PubMed:21304598). Expressed in adult animals with increased expression in 10-day-old animals (PubMed:16324156)
+In female, expressed as follicles enter the secondary stage until ovulation occurs. In the male reproductive system, the expression is limited to spermatocytes and spermatids
+Induced within 3 hours after growth stimulation, remains elevated with no apparent cell cycle dependency
+Expressed both maternally and zygotically. Embryonic expression is highest at 0-8 hours
+Present in lateral root primordia
+First detected as stage 6 in the forming neural tube and somites, but not in trunk surface ectoderm. By stage 8, expression persists in the cranial ectoderm and is up-regulated in the presomptive olfactory placodes. By stages 11-12, expression declines in the neural tube, but not in the cranial ectoderm; in somites, expressed all along the rostral-caudal axis as well as in presegmental mesenchyme caudal to the developing somites. Lens and otic placode expression first visible at stage 12, strongest at stages 13-16. Detected uniformly in ectoderm and mesenchyme of the limb primordia at stage 17. By stage 18, decrease of ectodermal, otic, lens and olfactory placode expression; expression appears in the epibranchial placodes. By stages 22-30, highest levels in the most distal mesoderm of the autopod, in the ventricular zone of the neural tube from the forebrain to the spinal cord, in the dermomyotomes and the tail buds
+Detected in globular-stage embryos in the epidermis with the highest concentration at the apical region. At early heart stage, expression is restricted to the two cotyledon primordia and the meristem. In the late heart to torpedo stages, expression is restricted to the meristem and the cotyledon tips. In mature embryos, stricly expressed at the apical meristem. During seedling development, highly expressed in young leaf primordia and the apical meristems. Detected in the protodermal cell layer of the embryo and the meristem L1 layer at the site of organ initiation. After transition to the reproductive phase, detected in the inflorescence meristem and at various stages of floral development
+Expressed in sepals at stages 11, 12 and 13 of flower development. Highly expressed in petals at stages 9-10, decreases at stage 11 and disappears after flower stage 12. In anthers, expressed at stage 11 in the tapetum, disappears early in stage 12 when the tapetum degrades and reappears throughout the anther late in stage 12 to persist at least until stage 13. In stamen filaments, expressed at stages 12 to 13, especially near the apical end of the filament. Expressed throughout the gynoecium at early stages up to stage 12, especially strongly in ovules. Expression in gynoecium decreases late in stage 12, but persists through stage 13, especially near the apical end including the style. Expressed in the mesocarp of the fruit and the carpel septum during fruit growth
+Expressed at 7, 11, 15 and 17 dpc
+Highly expressed at 14 dpc with lower levels at 18 dpc and P3
+Expressed in all development stages
+More abundant in fetal brain compared with the adult brain
+Transcribed during early mouse development. Detected at all developmental stages from the egg through the blastocyst, most abundant at the 2-cell stage
+In the embryo, expression increases at 12.5 dpc-14.5 dpc. Levels are highest in pre- and postnatal stages which coincide with peaks of cerebral and cerebellar neurogenesis (at protein level)
+In stage 13 embryos at the beginning of dorsal closure, enriched in the leading edge of the epidermis (at protein level)
+Strongly expressed in the shoot apical meristem (SAM) and the young leaf primordia. Also detected in the lamina of the cotyledons, especially in the mesophyll and vascular bundles
+Isoform 3 is specifically expressed in primary spermatocytes at the pachytene stage, but not those at leptonema stage. Not expressed in other testicular cells, including spermatogonia located in the basal compartment of the seminiferous tubule or spermatids
+During embryogenesis, expressed just before hatching at low levels
+Expressed throughout pollen development with a at mature pollen stage
+Highest levels in pachytene and diplotene stage spermatocytes and primordial germ cells of the male and the female
+First detected at 11 dpc. Expressed in fetal liver at 12.5 dpc and 13.5 dpc
+First detected at around 8 hours post-fertilization (hpf) within the prospective midbrain-hindbrain boundary (MHB). By 10 hpf, expressed in two stripes that converge at the dorsal midline. During somitogenesis, this expression domain extends to the prospective epiphysis and the dorsal midline of the hindbrain; unlike wnt10b, wnt1 is not detected in the prospective cerebellum. The hindbrain domain bifurcates along the midline to form two dorsolateral columns with transverse bands of up-regulation at rhombomere boundaries; these are refined into stripes which are maintained at least until at least 48 hpf. At 30 hpf, expressed in the epiphysis, the dorsal midline of the optic tectum, the anterior half of the MHB constriction and in the hindbrain walls. Not detected in adults
+Specifically expressed in subsets of neuronal tissues, epithelial cells, and developing somites through which vascular endothelial cells migrate from large ventral axial vessels to form stereotypic intersegmental blood vessels (ISV)
+Abundantly expressed between embryonic day 9.5 and 12.5
+Expressed at low levels in larvae and adults. Expression increases during L2-L3 molting stage an prior L3-L4 molting stage
+Developmentally regulated with primordia/ immature fruiting bodies having much higher levels of priA
+Present in spermatocytes. Expression is lost as cells exit prophase I. Not detected in spermatids (at protein level)
+Expressed both maternally and zygotically in all stages
+Expressed during the parasite blood stage, specifically in schizonts (at protein level)
+Expressed during very late stages of embryogenesis. Later, its expression follows a development dependent gradient in successive leaves
+Expressed at the time of rudimentary glumes differentiation in a half-ring domain at the base of the rudimentary glume primordium
+Present in embryo. Decreases before birth
+Elevated levels of expression during entry into the stationary phase of the growth cycle
+During elongating primitive streak stages, it is expressed in the rostral and lateral epiblast and in the Hensen's node. From 2.5 days of development (2.5 dpc) on, it is expressed in various ectoderm- and mesoderm-derived structures. In the skeletal muscle lineage, it is highly expressed in the early myotome and, at later stages, in all skeletal muscles of the embryo. From 9 dpc to hatching, expression in the muscles decreases dramatically but is maintained in satellite cells of adult muscles
+Expressed continuously during kernel development
+CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase
+Expressed predominantly in embryonic and larval stages
+Expression is restricted to prosome, mesosome and anterior metasome
+Expressed during the late sporulation phase
+Expression peaks at stage 2 of petal development
+Not detected in brain one week after birth, prior to the onset of myelination, and levels are low two weeks after birth. Expressed at high and constant levels in brain after three weeks and later (at protein level) (PubMed:24903835). Expression is developmentally regulated during brain ontogeny, rising 2-3 week postnatally, and is maximal in adult brain (PubMed:8034741, PubMed:24903835)
+Accumulates in germinating seeds as well as in leaves
+Expressed specifically in the embryo surrounding region at the micropylar end of the seed endosperm at early stages (4 to 7 days after pollination, DAP) and ever-decreasing parts of the suspensor at subsequent stages
+Detected in embryonic brain at 13 dpc. Levels in brain decrease gradually after 15 dpc, but expression continues after birth (PubMed:21673655). Detected in embryonic myocardium, body wall and pro-epicardial organ at 9.5 dpc. Detected throughout the myocardium at 10.5 dpc, but levels in the epicardial cell layer are strongly decreased. Almost exclusively detected in the neural tube at 14.5 dpc (at protein level) (PubMed:21350012). Detected in the chorion and visceral endoderm between 6 and 8 dpc (PubMed:19056886). Detected in the visceral endoderm at 7 dpc, with a gradient from high expression in the anterior part to low expression at the posterior part (PubMed:19056886). At 8 dpc, detected in definitve endoderm, parts of the neuroectoderm, the headfold and posterior mesoderm (PubMed:19056886). Detected in the developing brain, the proepicardial organ and in somites at 8.5 dpc (PubMed:16872596, PubMed:18448090). At 9.5 and 10.5 dpc, detected in telencephalic vesicles, at the midbrain boundaries with forebrain and hindbrain, the hypothalamic region, in the apical ectodermal ridge, pharyngeal arches, the developing eye, the epithelial structures surrounding the lower region of the developing heart, limb buds and somites (PubMed:16872596, PubMed:18448090). At 10.5 dpc, detected at interlimb somites with loss of expression at limb somites and anterior trunk somites. At 11 dpc, detected in mesoderm in head and branchial arches, migrating germ cells and limbs (PubMed:16872596)
+Expressed during cell expansive growth and decreases during lignification (at protein level)
+Expressed both maternally and zygotically. Levels are highest at the preblastoderm stage but low levels are present throughout development
+Expressed throughout development, particularly in developing epithelial tissues
+During flower development, expressed at early stage in inner and outer integuments, and nucellar cells. Later, expressed in the integument cells but not in the embryo sac. In the mature ovule, highly expressed in the micropylar region. After fertilization, expressed in the seed integuments but not in the embryo
+Expressed in floral primordia, in STM-negative region, then in sepal primordia. As sepal develops, progressively confined to a basal core before disappearing. Present in stamen primordia, then confined to a central region as they become stalked and develop locules. Later reduced to procambial cells as stamen mature. From petal primordia, expressed on the lateral edges of developing petals and finally confined to petal epidermis before disappearing. Present in carpel primordia, then in inner side of carpels especially in the placenta. Strong levels in ovules primordia and young ovules, then localized in integuments initiation zone before being confined to inner integument cells that will differentiate into the endothelium. Expressed in the distal half of the funiculus throughout ovule development and later extends into the chalaza. After fertilization, expression shift to the embryo. First on the apical part at the globular stage, then in cotyledons primordia, and later in cotyledons during the torpedo stage. As cotyledons grow out, expression becomes limited to a plane separating adaxial and abaxial parts. Excluded from the embryonic central region (ECR). In seedlings, found in leaf primordia then in central and lateral actively developing regions of extending leaves
+Not expressed during development, is induced during establishment of satellite cells and acquisition of quiescence
+Expressed at low levels in undifferentiated mesenchymal stem cells and then shows increasing expression levels as differentiation proceeds
+Expression is limited to the pluripotent cells of the early embryo and the germline. Expressed in blastocysts, epiblasts and purified primordial germ cells
+Expressed in whole mesoderm at onset of gastrulation. From day 2, confined to endothelial tissues and expression continues to be widespread throughout vascularization until 9 dpc where it becomes restricted to specific regions such as the spinal cord and heart valves
+Detected in the blastoderm margin by 4 hours post-fertilization (hpf). Expressed in the yolk syncytial layer (YSL) from 9 hpf to 24 hpf. By 48 hpf expression decreases in the extraembryonic YSL and is detected in the embryonic liver primordium and intestinal tube in which strongly expressed by 4 days post-fertilization (dpf). At 6 and 15 dpf expression is restricted to the two main liver lobes and the anterior part of the intestine including the intestinal bulb, but not detected in the pharynx or posterior intestine. Expressed in the enterocytes of the anterior part of intestine as well as in the hepatic cells in 15 dpf larvae. The total level of expression is very small before 2 hpf, increasing significantly between 2 and 5 hpf, and remaining high at 6 and 9 hpf. A significant decrease in the expression level is detected at 12 hpf and low level remains until the end of embryogenesis, which occurs by 72 hpf
+First detected in oogonia cells and highly expressed in late vitellogenic oocytes during oogenesis
+Expressed in the embryonic heart (at protein level)
+Expressed at all developmental stages (PubMed:15704008, PubMed:17574230). In larvae, highly expressed in the head ganglia neurons and the developing hermaphrodite vulva and male tail, while expression in most somatic cells is weak (PubMed:17574230). Not expressed in the gonads in larval stages (PubMed:15704008)
+Detected at stage 25 and steadily increases, with high levels at the late tailbud stage
+Different-sized isoforms are expressed in the adult and cercarial stages
+Thirteenfold increase in expression between 4-cell and 12-cell embryos
+In brain, expression peaks at 13-15 dpc, during cortical neurogenesis. At 8.5 dpc, expressed in forebrain and midbrain. At 14.5 dpc, expressed in ventricular zone, subventricular zone and cortical plate
+At 10.5 dpc, a very low level is mostly confined to the central nervous system and the developing heart and kidney, while at later stages it is present in other organ systems
+During seed development, first expressed in developing endosperm, embryo and suspensor and later restricted to the embryo. In seedlings, confined to apical meristems and vascular tissues. In flowers, mostly present in floral meristem, in filaments of the stamen and in the style
+During the asexual blood stage, expressed in trophozoites, schizonts and free merozoites (at protein level)
+Expressed mainly in the actively growing and dividing cells
+Ubiquitous expression during the bud stage in 10-hpf embryos. Later, at 24 hpf, mct8 is most abundant in the forebrain, midbrain, hindbrain, spinal cord, notochord, and eyes. At 48 hpf, mct8 expression is mainly observed in the brain and along the spinal cord
+At about 6 to 9 weeks estimated gestational age (EGA), expressed in the periderm during the early period when the two-layered epidermis form. At 10 to 13 weeks EGA, expressed in the entire epidermis with high expression in periderm until to 14 to 22 weeks EGA
+Not regulated during the cell cycle (at protein level)
+Expressed in embryo, wing disk and eye disk. Broadly expressed in 3rd instar larval brain, including neuroblasts, ganglion mother cells, and neurons
+Expressed in intestine from late embryogenesis onwards, and in the body wall muscle and pharynx from L2 onwards
+Expressed late in chlamydial development, during the transition from reticulate bodies to elementary bodies
+Functions in the late cell cycle G1 phase for progression into the S phase, possibly associated in two separate complexes with the phosphorylated forms of p155 and p190, two high MW proteins
+Appears during cell differentiation; absent in amoebae and early stages of development, reaches a maximum level of expression at the slug stage and then decreases
+Accumulates during oocyte maturation
+Expressed in immature (78 days post-seedling) and mature seeds
+Expressed in the cerebral cortex at 14 dpc (at protein level). Expressed in the walls of the third and fourth ventricles, and in the hippocampus during development
+Expressed by 12.5 dpc in essentially all differentiating neurons in the mantle layer of the myelencephalon, metencephalon, diencephalon, spinal cord and several sympathetic ganglia. During later stages of prenatal development, widespread expression continues in post-mitotic neurons of both the CNS and PNS and begins in endocrine cells of the anterior and intermediate pituitary
+In the developing pancreas, expressed exclusively in the insulin-positive cells from 13.5 dpc onward and never in the glucagon-expressing cells (at protein level) (PubMed:14973194). At 12.5dpc, at the mRNA level, detected in each formed somite, in myotomal cells. Also detected in the head neural tube, liver cells and, at low levels, in some mesenchyme-like cells (PubMed:14680841)
+Apically located within the epithelium of the developing basilar papilla at days 5.5 dpc to 8 dpc. As development proceeds, expression becomes restricted to the basal layer. In the utricle, alpha-tectorin is first expressed at 4.5 dpc
+Expression begins as early as 6.5 dpc and very early in fetal liver (at least from 11.5 dpc). Expression level changes in different developmental stages. Levels decrease to a minimal level at 17.5 dpc and then increase gradually to the maximal level at about 7 days after birth
+During development at embryonic day 18.5 dpc, expressed in the outer neuroblastic layer of the retina where developing postmitotic photoreceptors and retinal progenitors reside (at protein level)
+Widely expressed at early stages of embryonic development but is confined to bones, skin and the hematopoietic system at later developmental stages
+In somatic embryos, expressed at low levels during the first phase of maturation and is most abundant 14 days after maturation begins. Not detected in zygotic embryos
+Strongly expressed in developing and mature embryos
+Expression detected in embryo, larva and adult
+At 8.25 dpc expression is strongly elevated in the anterior midline. At 8.5 dpc expression is elevated throughout the anteroposterior extent of the notochord and is down-regulated in the heart. At 8.75 dpc expression is increased in the ventral brain. At 9.5 dpc strong expression appears besides the notochord including the apical ectodermal ridge (AER), the isthmus and the ventral diencephalon. At 10.5 dpc expression increases in the notochord, the AER and spinal and brain neurons
+Increases during floral transition and stay high thereafter
+Expression peaks early in embryogenesis (day 13.5) and is undetectable 14 days after birth
+Isoform 2 and isoform 3 are not expressed at 1 day before birth, relative concentration of both isoforms increases with the age of the animal, reaching maximal levels in the adulthood
+Expressed throughout the embryogenesis in the provascular tissues
+Detected only in the oocytes at all developmental stages of the follicle including primary, secondary, preantral, and antral follicles with an increase in signal during development. Readily detectable at the mature oocyte, but disappears at 2.5 dpc. Detected in germinal vesicle (GV) and metaphase II-stage oocyte (at protein level)
+Specifically expressed in the L1-layer of the meristem and protoderm (epidermis) of leaf primordia. During leaf development, expressed in protoderm from plastochron 1 (P1) to P4 and down-regulated at P5 to then disappear. Expressed in the epidermis of primary rachis branch, and in the protoderm of secondary rachis branch primordia. Expressed similarly in L1-layer or protoderm in young and developed floral shoots. During embryogenesis, expressed in the outermost (epidermal) cells 2 days after pollination (DAP) and later at 4 DAP in protodermal cells without any organ differentiation. In nearly mature embryo, strongly expressed in protoderm in the shoot apical meristem (SAM) and lateral organ primordia
+Expressed in lens at P1 and P7 (PubMed:21778275). The expression levels are higher than in adult lens (PubMed:21778275). Detected in the basolateral membrane of the lens epithelium, with strong staining at equatorial epithelium, and in differentiating secondary fiber cells at P1 (at protein level) (PubMed:21778275)
+Expressed throughout embryo development from the heart to mature embryo stages
+At 16 dpc, widely expressed in all tissues tested
+Preferential expression during the early to mid stages of corticogenesis. High levels in the early radial glial progenitors from 10 to 17 dpc and gradually decrease thereafter (at protein level) (PubMed:27142930)
+Specifically expressed in the germline from the L1 larval stage
+At embryonic stage 8 is expressed in the left lateral plate mesoderm, bilaterally in the head and in a small horizontal domain coincident with the second caudal somite. By stage 9, expression in the right side of the head has disappeared and all remaining expression in both the head and trunk is on the left. The most medial domain of expression expands caudally as new somites form
+At 9.5 dpc, expressed throughout the ventral mesoderm of the trunk and head. At 10.5 dpc, maintained in the ventral aspect of the axial tissues; detected in the branchial clefts, branchial arches, in the heart and in the cranial mesenchyme underlying the mid-brain. No expression in the dorsal part of the embryo, in the somatopleure nor in the splanchnopleure. At 11.0 dpc, expressed in the branchial arches in the mesenchyme underlying the ectoderm, but not the endoderm
+Expressed during lateral root development
+Expressed in oocytes throughout development
+At 8.5 dpc, expression is confined to the non-neural ectoderm immediately adjacent to the neural plate, which was undergoing folding to form the neural tube. At later time points, more widespread expression is observed in the surface ectoderm, with a progressive increase until 15.5 dpc. Also expressed in other tissues lined by squamous epithelium, including the oral cavity, urogenital sinus and anal canal
+Expressed in the procephalic region and in the clypeolabrum from stage 8 on and later in the brain and the central nervous system
+At 13.5-14.5 dpc, strong expression in ureteric buds (at protein level). Expression decreases in the kidney after birth (at protein level). Expressed in the eyes and limbs during development (at protein level)
+Ubiquitously expressed from day 7 to 17 dpc
+Up-regulated during postnatal lung development
+Expressed as early as the germinal vesicle (GV) stage oocyte, and persists into the metaphase II stage oocyte, the oocytic polar bodies, and the 2-cell embryo, and disappears at the 4- to 8-cell embryonic stage
+Expressed at high levels in the hippocampus at the earliest time at which it is defined as a structure and also in ventricular neural cells as well as differentiating neurons outside of the ventricular region. Expressed during development in lower levels in mesenchymal cells derived from the neural crest that are destined to form bones of the skull
+Specifically expressed in the mammalian blood stage form (at protein level)
+Enriched in tissues with differentiating ciliated cells including 18.5 dpc trachea and bronchus
+Expressed in the surface glial cells of the nerve cords at the larval stage (at protein level). Expressed primarily in embryos and pupae
+Expressed maternally and zygotically (PubMed:2576013). Expressed during oogenesis and throughout development (PubMed:2576013, PubMed:11546740)
+Expressed at high levels in early embryos from 1-cell stage until at least blastula (PubMed:24357321). Expressed during embryonic development in both somatic and primordial germ cells from 9.5 dpc, with a peak in primordial germ cells at 16.5 dpc (PubMed:23151479)
+Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in the gonad/mesonephros complex at stage 25. Isoform 1 is expressed in somatic cells of the gonad mesonephros and somites of a tadpole at stage 25
+Expressed during parasite asexual blood stages, specifically at the schizont stage, in free merozoites, and at the very early ring stage but not in late ring and early trophozoite stages (at protein level)
+Undetectable in unfertilized eggs and in embryos at 2 and 4 hours post-fertilization (hpf) (PubMed:35460869). Also not detected in embryos at 6 hpf (PubMed:19757381). Expression is detected in the embryo at 12 hpf (PubMed:19757381). Expression is also detected in the larva and adult (PubMed:19757381, PubMed:26598617)
+Can transform NIH 3T3 cells
+In cerebellum, abundantly expressed during the first two postnatal weeks, with levels decreasing thereafter. In primary granule neurons, highly expressed at postnatal day 6 (P6), with levels decreasing with neuron maturation (at protein level)
+Expressed in early stages of follicle development up to large white follicles with highest level in small white follicles
+Detected at 10 dpc in the hindbrain and at 11 dpc in the forebrain. During the next 3 embryonic days the levels of RTN1-S increases and remains stable at 13 dpc in the hindbrain and at 14 dpc in the forebrain. The levels of RTN1-B does not change as significantly during development of the hindbrain
+Highly expressed in developing anthers before pollen mitotic divisions from stage 8 to stage 12, with a peak of expression at stage 9 (at protein level) (PubMed:29915329). Expressed in developing seeds from 3 to 10 days after flowering (at protein level) (PubMed:29915329)
+Expression begins at the 3-fold embryonic stage
+Expressed in the embryonic heart at 10.5 and increases from 14.5 to 16.5 dpc, and then gradually decreases until postnal day 7 (PubMed:26489465). Expressed during the testicular development from embryonic day 18.5 to postnatal day 35 (PubMed:25611385)
+Low levels at prenatal stage 15 dpc, increased levels during the first postnatal days, with a plateau at postnatal day 15
+The alpha-2* subunit isoform is present in neonatal rats, but not in older animals (PubMed:2176511, PubMed:1707830). Isoform Alpha-2* and isoform Alpha-2B are detected in embryonic and neonatal brain. At later postnatal stages, isoform Alpha-2* levels greatly decrease while isoform Alpha-2B is barely detectable (PubMed:1645300)
+In testis, isoform 1 and isoform 2 are expressed only in the adult from postnatal week 7. Expression is detected in pachytene spermatocytes, increases greatly in round spermatids and is very strong in round/elongating and elongating spermatids. Expression is reduced in condensed spermatids and persists in spermatozoa. Isoform 3 is specifically expressed in round spermatids and is greatly reduced in spermatids under maturation (at protein level). Isoform 7 is detected in the embryo from day 10 while isoform 7 is not detected until day 12. In brain, predominantly expressed by granule cells during cerebellar development. Isoform 1 and isoform 3 are differentially expressed during cerebellar development
+Expressed in the developing retina, and in a tiny population of ventricular cells located in the ventral domain of the spinal cord and hindbrain. Retinal expression peaks at stage 29 (6 dpc)
+During anther development, expressed at the late premeiosis and meiosis stages in both the anther wall and the microspores. After meiosis, expressed in the tapetum, connective tissue, and vascular bundles
+Expressed both maternally and zygotically. Expression decreases after gastrulation
+Expressed during flower formation
+Expressed in DRG neurons of 12 dpc embryos
+During early stages of embryogenesis, broadly expressed throughout globular and torpedo stages. At late torpedo stage, strongly expressed in developing vascular cells and weakly expressed in surrounding cells. By the walking-stick stage, restricted to incipient vascular cells of the apical loop, the midvein of the cotyledon and the root vasculature. In emerging leaves, strongly expressed in procambium and weakly expressed in areole cells. Limited to developing vascular cells in later stage of leaf development. In roots, expressed in procambium of the elongating zone and in immature vascular cells of the root differentiation zone. During inflorescence development, broadly expressed in young floral buds, and gradually restricted to procambium of cauline leaves, sepals, petals, gynoecia and anthers
+Expressed in salivary glands (at protein level) (PubMed:11535823). Is present at low but detectable levels in the earliest embryos, increasing at 6-8 hours with a maximum at 10-12 hours (PubMed:7729408). Levels decrease thereafter and are not detected in 18-20 hours embryos and first instar larvae but is detected again at second instar to pupation (PubMed:7729408)
+Up-regulated in the S-G2 phase
+Ubiquitous expression during early development at 1 dpf, but by 2 dpf, transcripts are virtually undetectable in the major axial skeletal muscles
+Expressed highly during embryogenesis. Expressed in the endoderm in cells of the gut lineage beginning at the 2E cell stage (endodermal cell stage) of embryogenesis through to adulthood
+In inflorescences, observed at the tip of coleoptiles, paleas, lemmas, lodicules, anthers, carpels, receptacles and rudimentary glumes
+Abundantly expressed at early developmental stages but decreases slightly when embryos proceed in development (PubMed:27377701). Expression is strongly detected from 0.25 to 3 hours post-fertilization (hpf) in embryos, but it is only weakly observed at 12 hpf (PubMed:27377701). At 24 and 36 hpf, signals are observed only around the eye with stronger intensities at 24 hpf than 36 hpf (PubMed:27377701)
+Expressed in cells competent for DNA transformation; that is 5-20% of the population (PubMed:16009133)
+Detected early in hemopoiesis: in the yolk sac at 11.5 and 12.5 dpc and, to a lesser extent, in the liver at 14.5 dpc
+Expressed in 1- to 100-cell stage embryos
+Expressed in the developing embryo from the earliest stages of cellularization and is subsequently found in many cell types
+Associates with centrosomes, during nearly all of the developmental stages. In the hermaphrodite gonad, it localizes as discrete perinuclear foci in the mitotic portion of the germline. These foci are also evident during the early stages of oogenesis but are absent in mature oocytes. In contrast, in mature sperm these foci are present with each male gamete containing a single dot adjacent to the nucleus. Similarly, in meiotic stage embryos, a single expression dot is observed next to the male pronucleus. In slightly older embryos, one or two perinuclear foci are observed. The intensity of the foci increase with the age of the embryos and at mitosis it localizes to both spindle poles. As embryos progress through anaphase and telophase, the intensity of staining gradually diminishes. Careful examination of the staining pattern at this stage reveals a diffuse expression centered on one or two very bright dots corresponding to both centrioles as well the pericentriolar region
+Expressed throughout development, levels are high during embryogenesis but low in following stages
+Accumulates at the boundaries between the apical meristems and lateral organs in embryos, seedlings, and mature plants, and at the root apical meristem and in distinct cell files surrounding this area. First observed in heart-stage embryos, in the cotyledon boundary region of the shoot apex, and in the quiescent center and columella initial cells at the root tip. In bending-cotyledon stage embryos, weakly expressed in the boundary cells between the shoot apical meristem (SAM) and the cotyledons. In seedlings, accumulates in cells between the SAM and the cotyledons. During the reproductive phase, restricted to the basal regions of the pedicels and floral organs. In the inflorescence shoot apex, expressed in the early flower primordia, but not in the SAM. Later present in the cryptic bract region, but not in the floral meristem
+Developmentally regulated. Preferential expression in both fetal and adult hematopoietic progenitors and mature blood cells during embryonic and adult hematopoiesis
+In embryos, first detected at the 1 cell stage but disappears by the 2 cell stage (PubMed:30903017). Expressed again from 24 hours post fertilization (hpf) (PubMed:30903017). At 24 hours post fertilization (hpf), detected in a few cells in the embryo hindbrain (PubMed:30903017). In larvae, expressed in the neurons and nerve fibers of the midbrain tegmentum and hindbrain (PubMed:30903017). In the hindbrain, expressed in reticulospinal neurons with spinal projections (PubMed:30903017). Axons of hindbrain neurons project into the dorsal spinal cord where expression often overlaps with galr2b (PubMed:30903017). In larvae, not detected in the hypothalamus and not detected outside of the brain (PubMed:30903017)
+It is a maternal protein that disappears by the late gastrula stage
+Levels are constant throughout development
+Expressed throughout the life cycle with lower expression in stationary phase promastigotes and higher levels in amastigotes
+Expressed throughout flower development (PubMed:20215586). In corollas, accumulates progressively during flower development, from buds to anthesis (PubMed:20543029, PubMed:20215586)
+Gradually expressed after germination
+Expressed during parasite asexual blood stages in schizonts and free merozoites (at protein level) (PubMed:29311293). Expressed in female and male mature gametocytes and gametes (at protein level) (PubMed:29311293)
+First detected 17 hours after insemination at the vegetal pole in late blastula. In 20 hour gastrula, expressed around the base of the archenteron and the lateral embryonic wall but not in the invaginated cells of the archenteron. In 34 hour gastrula expression persists around the base of the archenteron or at the blastopore but is not detected in either mesenchyme cells or the archenteron. In mouth forming embryos and in early bipinnaria larvae expressed in cells around the blastopore and anus. Not detected in cells of the mesenchyme and coelomic vesicles derived from the archenteron
+Post-meiotic phase of spermatogenesis
+Up-regulated expression throughout development
+Isoform 2 is expressed only in larvae
+Highly expressed during early embryonic development (at protein level). Low levels detected in the adult
+Expressed in a subset of cells of the olfactory epithelium, in the dental epithelium, in developing whiskers and in cells lining the endolymphatic duct of the inner ear at stage 16.5 dpc. Also expressed in kidney, hair follicles, thymus and in collecting ducts from the mandibular gland as well as in a subset of epithelial cells lining the sublingual and submaxillary ducts from the salivary glands to the oral cavity at stage 18.5 dpc. Expressed in the developing brain along a neuromeric boundary between prosomeres p5 and p6 as well as in the neural layer of the retina
+Developmentally expressed in primary sensory neurons and motoneurons. In trigeminal ganglia, expression increases between embryonic day 10 and day 12. High levels are maintained here throughout later stages of development and in adulthood
+Expressed in several discrete regions at 14.5 dpc and 19.5 dpc but not 10.5 dpc. At 14.5 dpc, expressed in isthmus, pituitary, spinal cord, tongue, intervertebral disk, dorsal root ganglion and pelvis. At 19.5 dpc, expressed in lung and anterior pituitary
+Expressed at 10.5 dpc, expression declines until birth after which it suddenly increases. Expression gradually decreases until postnatal day 10, (the day when DLBs start to occur), then again increases and reaches the levels present in adult brain
+Expression begins at the gastrulation stage. Expressed predominantly in the intestine from the comma stage onwards. In early larval stages, expressed in hypodermis and intestine. At L3 larval stage expressed transiently in spermatheca and dorsal uterus
+Expressed by immature cells in the process of extending cilia
+Highly expressed in most tissues up to 15.5 dpc. Thereafter, expressed at highest levels in the nervous system
+Expressed throughout development, low levels in embryos and first and second instar larvae, levels increase from third instar through to adult
+Strongly expressed in human embryonic brain (gestational age 12 weeks)
+Specifically expressed in late haploid male germ cells
+Is strongly detected in planulae, a little more detected in primary polyps (9d), and still a little more in both adult females and males (at protein level) (PubMed:33060291). Transcripts are expressed early in the life cycle and their expression is maintained through the adult stage (PubMed:29739837)
+Detected along the outer surface of the brain or along the fissure of cerebellar lobules at 13 dpc to P21
+Not expressed in fetal brain
+Expressed ubiquitously with elevated signal at the anterior-posterior (A/P) and dorsoventral (D/V) compartment boundaries and in peripheral wing disk cells (at protein level)
+By mid-exponential phase, CSF accumulates to concentrations that stimulate ComA-dependent gene expression (PubMed:10464187). Upon entry into stationary phase, CSF reaches high concentrations that stimulate sporulation and inhibit ComA-dependent gene expression (PubMed:10464187)
+In embryos, it is highly expressed in the neonatal brain and kidney and then declines substantially in the mature organs. Also expressed in lung and spleen. Expressed in the condensing metanephric mesenchyme and in early epithelial structures that are precursors to glomeruli
+First observed in the early-developing flower, in four zones between the initiating sepals and in their developing margins. Later detected in the margins of expanding sepals, petals and stamens, and in the leaf margins
+Embryonic, larval and adult stages. Expression is weak from 10 to 48 hours post-fertilization (hpf) and increases from 72 hpf
+VT2 is detected in mature oocytes and in embryos with a small number of cells (at protein level)
+Expressed throughout all developmental stages. First expressed at embryonic stage 15. Pupal expression first occurs 80 hours after puparium formation
+Expressed in rice seeds from flowering to mature seeds
+Elevated in mitosis; levels increase in mitotic cells and rapidly decrease once cells have completed chromosome attachment and exit from mitosis
+Expressed in the fetus (at protein level)
+Expressed throughout development. Weakly expressed during early developmental stages from shield to tailbud
+First detected at 8 dpc in the ossification center and the spinal cord. From this stage up to birth, expression extends throughout the bone tissue and strong expression is detected in the vertebrae. At 16 dpc, detected in the developing brain, including the prosencephalon, mesencephalon, diencephalon, telencephalon and rhombencephalon, and in the intestine. Faint expression at 16 dpc in the lung
+From embryonic day 14 through postnatal day 1, high expression in spinal cord, brain and some areas of the PNS. At 17 dpc and 19 dpc, high expression in spinal cord, mesencephalon and telencephalic structures as in olfactory neurons and in nasal epithelium. Strong expression also in the pituitary
+Expression correlates with root hair deformation
+Highly expressed in fertilized eggs as well as in all embryonic cells up to the end of gastrulation. Spatially restricted expression started after the onset of segmentation and was mainly localized in the developing pharyngeal arches. Transient expression was also detected in Kupffer's vesicle, a teleost-specific structure, and in lateral trunk and tail regions surrounding the neural keel, as well as areas of the developing pronephros
+At 18 dpc, expressed in most tissues, particularly in the skin. By neonatal day 1, the expression in brain and skin is markedly increased, whereas expression in the heart and skeletal muscles shows steady state levels similar to those observed in the fetus. At adulthood, very high expression in brain, little or no expression in other tissues
+Expressed in embryos and adults of males and females
+Present in the developing vascular bundle systems (PubMed:20151298). In the reproductive phase, first observed in the outer several cell layers of the rachis meristem and primary branch meristems (PubMed:20151298). Confined to panicles primodia and young panicles, particularly in the developing rachis branches (PubMed:20151298)
+Maternally expressed. Ubiquitously expressed through the 10 somite stage. Expression subsequently decreases in the trunk and tail while remaining high in anterior parts of the embryo. By 24 hours post-fertilization (hpf) expression is no longer detectable in the trunk and tail, but is maintained in anterior parts of the embryo. At 48 hpf expression extends along almost the entire length of the gut and is particularly high in the dorsal forebrain, ventral midbrain, and the dorsal posterior part of the midbrain. At 60 hpf, expression in the gut is restricted to intestinal epithelial cells. At 72 hpf, expression in the CNS is limited to cells in the diencephalon, the ventral midbrain and the dorsal part of the midbrain, while expression outside the CNS is restricted to the pharyngeal endoderm. Expression in the pharyngeal endoderm persists through 96 hpf
+Appears in S phase cells and remains present during mitosis until metaphase. Degraded at the onset of anaphase. During meiosis it is present until anaphase II and is then degraded. Not present in G1 cells
+At 6.5 dpc expressed in primitive endoderm, embryonic ectoderm, extraembryonic ectoderm and the ectoplacental cone. By 7.5 dpc, a widespread expression was observed in all intra- and extraembryonic tissues and also in the giant cells lining the inner boundary of the deciduum. At 9.5 dpc, expression was elevated in the neuroepithelium of the brain ventricles and the neural tube. By 12.5 dpc, expression remains widespread and in the brain higher levels were observed in the ventricular zone of the two telencephalic lobes, and in the mesencephalon and diencephalon, with the exception of the median sulcus. In adult brain, highest levels of expression were detected in cerebellum, specifically the Purkinje cell layer extending into the molecular layer
+At 24 hpf, expressed in the somites and several regions of the brain, including the midbrain roof (tectum)
+Expressed from 48 hpf in the nervous system, floor plate, and pronephros/interrenal gland. By 72 hpf and persisting through 96 hpf expression is present in the central nervous system (CNS), floorplate, interrenal glands/pronephros, and gut. At 72 hpf expressed in the brain and spinal cord
+Expressed in vegetative and early developing cells. Increases at 2.5 hours of development, and then decreases slightly. At 10 hours, there is a strong decrease followed by a almost complete decline at 25 hours
+Expressed both maternally and zygotically. Expressed throughout development with highest zygotic expression in third instar larva and pupae
+Very abundant in the oocyte and early embryo and reduced to very low levels by gastrulation
+Expressed in embryonal stem cells and in the developing brain (PubMed:1979677). Down-regulated in embryonic stem cells upon differentiation (PubMed:1979677). Expressed in the sciatic nerves at postnatal days P6 to P12 (PubMed:10068633)
+Expressed in most differentiated epidermal cells throughout development from embryogenesis to adulthood (PubMed:20876652). In late gastrulation, expressed in epidermal precursors (PubMed:20876652)
+At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 4. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 1/somite 2 boundary, and also expressed in the presumptive pronephric ducts
+In migrating PGCs, expression is first detected during germ cell differentiation
+Expressed during vein formation (PubMed:23437008). Decreased expression during seedling development (PubMed:23922907)
+Earliest expression is detected in late gastrulation (at protein level). Expression is strongest in elongated embryos and early larvae
+Present at all stages of development with expression detected in embryo, larva, pupa and adult
+Expressed in anthers early during endothecial development, with maximal expression during pollen mitosis I and bicellular stages
+Expressed by the early epiboly stage and reaches a steady state level of expression by mid-somitogenesis (PubMed:16672343). Shows widespread expression throughout the embryo during the first 24 hours of development, with enhanced expression within several structures at the 20-somite stage (PubMed:16672343)
+Expressed from 1 to 15 days after flowering
+Low though detectable expression at 10 dpc. From 15 dpc at least until 17 dpc, expression strongly increases. Down-regulated in the adult
+Expressed in germ cells at all stages of development
+Liver apoa-I expressed in fetal, newborn and suckling animals. Intestinal apoA-I only expressed in postpartum animals
+Expressed during L2 and L3 larval stages (PubMed:10359617). Highly expressed in vulval precursor cells P6.p in late L2 and early L3 stage larvae (PubMed:32053105)
+Expressed in vegetatively growing cells at very low levels
+Transcript levels remain constant in all phases of the cell cycle. In contrast, protein levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is reached
+Expressed in the developing nervous system. Expression is restricted to a subset of individual neurons in the mid- and hindbrain regions. At 10.5 dpc, expression level increases and extends further into the forebrain. The segmented pattern of expression becomes more refined and is indicative of peripheral nervous system labelling. Not detected in the area of motoneuron differentiation. Expression could be restricted to postmitotic neurons. Also expressed in fetal dorsal root ganglion, dorsal horn, in the dorsomedial mantle layer of the spinal cord, alar plate of the myelencephalon, marginal layer of the mesencephalon, basal plate of the pons, and cerebellar primordia, as well as the cortex of the olfactory lobe, retina, and olfactory epithelium. In the developing eye, expressed in differentiating ganglion cells and later in the development, also in amacrine cells. In adult, expressed in scattered cells throughout the brain
+At 6 weeks of age, detected in mesenteric and retroperitoneal fat pads. Expression prominently increases in mesenteric and subdermal adipose tissues at 30 weeks and is barely detectable at 50 weeks
+BetA is preferentially expressed in flagellate and BetB in amoeba
+Expressed in the intermediate and lateral mesoderm, posterior neural tube, notochord and somites of stage 9 embryos. Expressed in the neural tube, roof plate, notochord, somites, dermomymotomes and eye of stage 20 embryos. This expression pattern persists in stage 27 embryos, where expression is also seen in the heart, intestine and dorsal aorta. Weakly and uniformly expressed in the stage 35 embryo
+Detected in developing heart throughout embryonic development but only detected in developing liver close to time of birth. In the adult ovary, expression is highest during decidualization and early pregnancy
+Expressed at very low levels throughout development
+Is not expressed until 10 dpa (days post anthesis), accumulates to the highest levels between 20 and 35 dpa and levels decrease after 35 dpa
+Expressed in somatic tissues including neurons, body wall muscle cells, the vulva, vulval muscle cells, the hypodermis, seam cells, and intestinal cells at the L4 stage of larval development
+Ubiquitously found at 14.5 dpc with strong expression in heart, central nervous system structures such as cerebral cortex, hippocampus, olfactory lobe, trigeminal ganglion and spinal cord. Also expressed in diaphragm and duodenum
+Localizes to the centrosome throughout the nuclear division cycle in early syncytial embryos. Localization to the interphase nucleus is seen from nuclear cycle 9 onwards
+In the cortices of the adrenal glands, expressed at 12.5 dpc, decreases considerably at 15.5 dpc and is almost undetectable in the newborn stage. In brain, expressed at low levels in early embryos, expression peaks between 12 dpc and 14 dpc, and rapidly falls until birth when expression is barely detectable
+Specifically expressed in fetal kidney
+On embryonic days 15 (15 dpc) and 18 dpc, a weak expression is seen in the mantle and ventricular germinal zones throughout the neuraxis. On postnatal days 0 (P0) and P7, weakly expressed in the gray matter, but not in the white matter, throughout the brain. In the cerebellum, the expression is seen in the external granule cell layer
+Expressed at low level during vegetative growth and during early development. Higher levels of expression are detected later during development (12-24 hours)
+Induced at the onset of the maturation phase in the endosperm at low levels in a heterogeneous repartition, particularly in the chalazal endosperm. Also detected in pollen grains
+Expression begins at a low level shortly after the mid-blastula transition. Expression then increases during early and mid-gastrulation
+Expressed during pollen development and maturation
+Expressed in the early stages of embryogenesis under normal in vitro culture conditions
+Present during all stages of development
+Expressed in the developing eye as early as 14 dpc, with equal high expression levels after birth (postnatal day 1 (P1) and postnatal day 30 (P30))
+At the 10-somite stage, barely detectable in the paraxial mesoderm. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit at somite 1
+During inner ear development, detected early in the otic vesicle, and later in cochlear and vestibular sensory epithelia. Present in the presumptive organ of Corti by 14.5 dpc, and then confined to the supporting cell types at later stages of embryonic development and at the newborn. In the vestibular sensory epithelia, present at the lumenal surface. However, it is detected in the non-hair cell region, presumably in the lumenal processes of the supporting cells. Transiently expressed in the spiral and vestibular ganglion neurons (at protein level) (PubMed:19936227). First expressed at 8.5 dpc. In the newborn, broadly detected in neural retina. Later, in P10 retina, expression is enhanced in the inner nuclear and outer plexiform layers. Expression in retina decreases as development proceeded, and is detected in the inner nuclear layer and in a subset of cells in the ganglion cell layer of adults (PubMed:23543054)
+Induced in the early stages of infection of cotton plant
+Expressed specifically in prestalk cells
+Maternally derived transcript is detected at high levels at 1 and 3 hours post-fertilization (hpf). Not detectable at 6 and 9 hpf. Detected at intermediate levels at 12 and 15 hpf. Highly expressed at 18 and 24 hpf, after which expression decreases again. Detected in the anterior embryo at the 6 somites stage. Detected in hindbrain, rhombomeres and telencephalon at the 18 somites stage. Restricted to the anterior embryo, including brain, otic vesicles, and optic stalks in 24 hpf embryo. Detected in pectoral fin buds in 48 hpf embryo
+Expressed in bacteroids from pea nodules
+Expressed in liver at 72 hours post-fertilization (hpf) and gut at 96 hpf. Not detected at earlier stages of development
+Levels increase during embryonic development, drop at postnatal day 0 and increase again during postnatal development, reaching a mmaxium at postnatal day 21 before dropping slightly at postnatal day 60 (PubMed:18775783). In 13 dpc embryos, expressed at high levels in the trachea, liver, esophagus, lung and velo-pharyngeal region (PubMed:8268909). Also detected in the central nervous system (PubMed:8268909)
+From 5.5 dpc to 7.5 dpc expressed within the epiblast. At 8.5 dpc expressed throughout the entire embryo. Expressed in the gonadal germ cells at 11.5 dpc/12.5
+Mostly abundant in mature male strobili, with strong expression in mature female strobili but absent from developing strobili
+Expressed throughout the cell cycle. Transiently expressed in the root tip during seed germination up to about 21 hours after stratification. Expressed during lateral root primordia formation, vascular tissue development, in fertilized ovules, and torpedo- and heart-stage embryos
+In neuroretina, expression starts around embryonic day 7 (ED7) and increases until ED15. Still present after hatching. At ED7, also expressed in brain, but not detected on other tissues
+Synthesized and released from follicular epithelium 18-24 hours after a blood meal. Synthesis peaks at 36 hours and stops at 56 hours
+Expressed throughout amphibian metamorphosis
+Developmentally regulated. Expressed prominently in the developing thymus and the gut, and also weakly expressed in specific regions of the developing brain
+Expressed in embryos, juveniles and adults. Onset of embryonic expression coincides with early myocardial differentiation (PubMed:27217161). Expression is detected in cardiac tissue from stage 29 with the greatest concentration found in regions of actively growing chamber myocardium (PubMed:27217161). At stage 40, highly expressed in the left and right lateral sides marking the growing atrial chambers with lower levels in the dorsal atrial roof (PubMed:27217161)
+Expressed in all seam cells and in many other cells in the head and tail regions at embryonic ~1.5-fold and ~threefold stages (at protein level) (PubMed:11532911). Expressed in the vulval precursor cell (VPC) lineages and in VC neurons, starting at about the mid-L2 larval stage (PubMed:12399309). Expressed asymmetrically in seam cell daughters during larval life; expression is highest in the posterior daughter and lower in the anterior daughter cell after the L1 cell division (PubMed:23633508). However, in early stage L2, expression is symmetric in the seam-fated daughters of the first division (PubMed:23633508). Expression in the head and trunk increases with age between days 2 and 12 (PubMed:18662544)
+Peak of expression at stage 4 of flower development
+Display a characteristic dynamic and changing pattern of expression throughout the life cycle of the mouse (PubMed:12925589). Expression during early stages of development is specific of structures where multiple inductive interactions occur such as the limb buds, mammary gland primordia, heart cushions and valves among others (PubMed:19123136). Detected in a few cells of the extra-embryonic ectoderm of 6.5 dpc embryos. By 7.5 dpc, starts to be strongly expressed in the anterior visceral endoderm, as well as in the extra-embryonic membranes. By 8.0 dpc, expression extends to a highly localized region around the node and appears at the tip of the allantois. At 8.5 dpc, predominantly expressed in the allantois, the developing gut, the pericardio-peritoneal canal and somites. In 9.5 dpc embryos, persists in the umbilical cord, and is also found in the chorionic region. In later mid-gestation embryos, present at high levels in the apical ectodermal ridge and mesenchyme of the limb buds, in the peripheral nervous system, cranial nerves, and mammary gland primordia (PubMed:12925589)
+In stage 30 tadpoles, expressed in the dorsal and ventral forebrain and, at lower levels, the dorsal midbrain and hindbrain. At this stage, expression is not detected in the spinal cord, but is present in the overlying dorsal fin. Also expressed in the eye, trigeminal ganglion, branchial arches and cement gland
+Begins at embryonic day 10.5 in the developing ear, hypothalamus, the neural tube and dorsal root ganglia. It continues to be active throughout prenatal life in discrete regions of the brain with an anterior border in the ventral diencephalon at the optic chiasma and expression domains in mesencephalon, metencephalon, and myelencephalon. At midgestation, it is also expressed in mesenchyme of the head and branchial arches, and in some cranial ganglia, as well as in derivatives of neural crest, such as the truncus sympathicus and myenteric ganglia. In inner ear, it is expressed between 13.5 dpc and birth in non-sensory epithelium of the semicircular canals, utricle and saccule. Also expressed in the cochlea, where the expression is restricted to the stria vascularis
+Preferentially expressed in young cells
+Expressed in the developing cochlea. Expressed first in the prosensory domain and the expression is restricted to supporting cells as development proceeds (at protein level). In the embryo, expression is first detected on day 9 and increases up to day 18. Lower levels are found in adult. At 9.5 dpc, expression is localized to the apical ectodermal ridge (AER) of the developing fore- and hindlimb buds, the telencephalon and the first brachial arch. At 10.5 dpc, expression is also observed in the myotome and in sensory tissues such as the nasal pit and optic vesicle. Expressed in the developing brain and developing limb buds
+Expressed in the prestalk cells and prespore cells. Expressed only late in development. First detected in finger stage and expression levels peak in late culmination (18-22 hours). Its expression ceases upon cell disaggregation but is fully restored by exogenous cAMP
+Strongly expressed in the cotyledons and emerging radical of the germinating seeds one day after imbibition. Accumulates in the root tip of young seedlings and in the cotyledons and the basal region of the hypocotyl as the seedlings emerges from the seed coat three days after imbibition. Later confined to the basal region of the hypocotyls and to the root tip before progressively disappearing
+At 7.5 dpc, highly expressed in the ectoplacental cone and, at lower levels, in the embryonic and extraembryonic ectoderm. At 14.5 dpc, highly expressed in placenta and yolk sac, and, at lower levels, in brain and heart
+Expressed ubiquitously in embryos and early larval animals (PubMed:23851392). Expressed in MSpaa in embryos and in the pharyngeal M4 motorneuron at the first larval stage; expression in the M4 neuron and g1A cells decreases during larval development (PubMed:23851392). Strongly expressed in the seam cells and the hyp7 cells (PubMed:23851392)
+Only expressed during spermatogenesis in adult males and in hermaphrodites in the larval stage 4
+In B lineage cells, expressed in a stage-dependent manner at high levels in bone marrow pre-B and immature B-cells, and in spleen transitional 1 and follicular B-cells, but at lower levels in pro-B, transitional 2, and marginal zone B-cells
+Detected in the region of the apical meristem and cortical cells in the tip region and elongation zone of the roots
+Levels decrease at each developmental time point and further decrease during maturation into adulthood
+Highest levels of expression detected during silique development (PubMed:7647567). Hihghly expressed in the seed coat during seed development (PubMed:18266922)
+Expressed in a spatially restricted manner in embryos 8.5 dpc, expression is limited to the CNS with an anterior boundary in the hindbrain and extending posteriorly through caudal regions of the spinal cord. The same spatial expression is seen in embryos 9.5 to 12.5 dpc
+Expression detected in the intestinal cells from comma-stage embryo to adult stages, and also in the pharyngeal and body wall muscles from larva to adult stages
+Expressed in the epithelial cells of the tongue and palate at 17 dpc (PubMed:2433272). Expressed in ameloblasts at the periphery and at the incisal region of mandibular molars at P3 (PubMed:12657653). Expressed at the Tomes' processes of ameloblasts at the incisal region at P5 (PubMed:12657653). Expression at the incisal region decreased at P7 and P9 (PubMed:12657653)
+Albumen secretory cells produce perivitellin-2 during the reproductive period
+Expressed in fetal brain, kidney, liver and lung
+Expressed throughout development (PubMed:29346382). First expressed in the embryonic pretzel stage (PubMed:29346382). In L1 stage larvae, expressed next to the pharyngeal bulb, between the mouth and first pharyngeal bulb, in the pharynx and in cells posterior to the second pharyngeal bulb (PubMed:29346382)
+Expressed during primary neurogenesis. At the 3 somite stage (3s), expressed in rostrocaudal stripes in the posterior neural plate characteristic of the lateral zone, intermediate zone, and medial zone of primary neurogenesis. At 14s and 20 hpf, widely expressed in the spinal cord. By 24 hpf, becomes restricted to the posterior spinal cord. Expression also occurs in a dynamic segmental pattern in the hindbrain, at the mid-hindbrain boundary, cranial ganglia, midbrain, and forebrain. Isoform 1: Expressed throughout early development. Isoform 2: up-regulated from 9 hpf, when neurogenesis is initiated
+Not expressed in embryonic and immature rats. Expressed in parallel with synthesis of spermatids
+In embryos, expression is restricted to primordial germ cells (PGCs)
+CDC2C transcripts accumulate during S phase as well as during the G2 and M transition
+Expressed in fetal liver, lung and kidney
+Expressed during the asexual blood stage, including in the trophozoite and schizont stages, and in free merozoites (at protein level)
+Found exclusively in prestalk cells
+At the globular stage, expressed in cells adjacent to the hypophysis and at later embryonic stages, specific for vascular tissues
+Detected in developing and mature leaves of adult plants. Levels of PD-L1 are highest during the winter, levels of PD-L2 remain constant throughout the year. Not detected in young (8-34 month old) plants
+During embryogenesis detected from 7 dpc onward in tissues derived from mesoderm and ectoderm
+In the developing spinal cord expressed at 11 dpc and 13 dpc dorsally in the region of the commissural and association neuron cell bodies and ventrally in subpopulations in the motor column. In the brain detected between 15 dpc and 18 dpc, between P0 and P10, and in adult in regions of the hippocampal system and the basal ganglia. Detected at 18 dpc, between P0 and P10, and in adult in anterior olfactory nuclei, regions of the cortex and basal telencephalon
+Expression begins in the late blastula, peaks at state 11 (early gastrula) and decreases thereafter
+Highly expressed at 30 dpc to 60 dpc in the testis. Reduced expression at 90 dpc
+Shows increasing expression levels in testis during postnatal stages, reaching highest levels by postnatal day 50. In testis, first detected in pachytene spermatocytes (stage VII), reaching peak expression in meitotically dividing spermatocytes (stage XII)
+Ubiquitously expressed in the embryo at 14.5 dpc
+Expression levels decrease throughout development
+At 16 and 24 hpf, restricted to muscle precursor cells in somites. Also detected at 48 hpf
+Immature eggs have higher levels of NADase transcripts than the mature ones
+Expressed only after cells have aggregated and, then, preferentially in prestalk cells
+Expressed throughout the life cycle with no major peaks of expression. In the embryo, uniquitously and highly expressed at precellular and cellular blastoderm stages
+Very lov expression in young embryos, increasing during maturation
+Expression significantly increased from 10.5 dpc to 16.5 dpc, and subsequently remained constant until 21 days after birth. In 9.5 dpc to 10.5 dpc embryonic heart, expression is primarily associated with developing premyofibril structures containing alpha-actinin
+Expressed throughout growth and development. Exclusively localized in the prestalk cells
+Not expressed at 10.5 dpc. First detected at 12.5 dpc in the primordial liver (PubMed:19729679). Increased hepatic levels are found at 15.5 dpc followed by decline throughout newborn stage P1 and postnatal stages P5 and P10 with no hepatic expression in the adult (PubMed:19729679). In bone marrow, expressed during late gestation stages and remains elevated until adulthood (PubMed:19729679). In newborn and adult mice, also expressed in spleen (PubMed:19729679)
+Detected in the non-neural ectoderm from cleavage to early neurula stages and in the caudal hindbrain and the mandibular arch at tail bud stages
+Expressed in spermatocytes and spermatids in different stages of spermatogenesis (at protein level)
+Expressed at the ring stage during the asexual blood stage
+It is first observed after neurulation, in 10.5 dpc rat embryos, and is restricted to subsets of neuroepithelial cells in the spinal cord and the brain, between 10.5 dpc and 13.5 dpc. In the periphery, its expression is restricted to some lineages of neural crest-derived cells, namely in sympathetic and enteric neural precursors. In the PNS its expression is extinguished at or before differentiation
+Expressed during gastrulation (from 6.5 dpc to 11 dpc) in two spatial domains that correspond to the axial and lateral mesoderm. In the first domain expression is progressively localized to the anterior primitive streak, the head process, and the node and notochordal. In the second domain, expression is initially concentrated in the lateral region of the egg cylinder, and is later found circumferentially in the intermediate and lateral plate mesoderm. Furthermore, the expression can also be detected at the early head-fold stage in the midline neuroectoderm, and consequently is an early marker for the prospective floor plate of the neural tube. Expression ceases at the end of gastrulation, and has not been observed in later embryonic stages
+Expressed up until the first flowering buds, after which, levels dramatically decrease
+Expressed in embryos and during larval development (PubMed:16014321). Expressed strongly in cephalic sheath (CEPsh) glia at all developmental stages and in some motoneurons of the ventral cord in larvae (PubMed:18508862)
+Up-regulated during differentiation into adipocytes in various cell lines, including TA1 and 3T3-L1 (PubMed:1339452, PubMed:18334488, PubMed:18654663, PubMed:22245780). Decreases in the mammary gland during pregnancy from day 14.5 until 18.5, when it becomes hardly detectable, and during lactation (PubMed:1339452, PubMed:18334488, PubMed:18654663, PubMed:22245780)
+Expressed in the developing brain (PubMed:23864681). Expressed in the apical aspect of the ventricular zone, in the marginal zone, in a narrow stripe between the intermediate zone and the cortical plate at 14.5 dpc (PubMed:23864681). Expressed in multipolar cells at 14 dpc (at protein level) (PubMed:23864681). Expressed in neuronal stem/progenitor cells at 14.5 dpc (PubMed:24173802)
+Expressed both maternally and zygotically in all stages of development (PubMed:9065698). Highest expression is in third larval instar (PubMed:9065698, PubMed:10549280). Expressed in the larval Garland nephrocytes and in the adult (at protein level) (PubMed:10549280, PubMed:27253064)
+At 13.5 dpc, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, caudate putamen, cerebellum, cerebral cortex, hippocampus, olfactory bulb and thalamus
+At 14.5 dpc predominantly expressed in the nervous system
+Expressed in sex myoblasts at the 16-M cell and 18-M cell stages of mesoderm development in hermaphrodite larvae
+During vegetative phase, expressed in the entire shoot apical meristem and in emerging leaf primordia. During floral transition, gradually detectable in the transitional shoot apex and young cauline leaves. Detected in the inflorescence meristem. Present throughout the tunica (superficial layers) of the floral meristem during early stages of flower development. Later disappears prior to emergence of sepal primordia. At later stages of floral development, weakly expressed in the distal parts of stamens and carpels. Then restricted to pollen and the adaxial surface of the gynoecium
+First expressed at 50% epiboly in the shield region. During somitogenesis, present in the spinal cord and endoderm with an anterior expression limit at around rhombomere 4
+Unlike Xenopus laevis act3, expression is restricted to embryonic and tadpole stages. Not expressed in adults
+Expressed in the germ ring at the blastoderm margin during the shield stage and when embryo reaches 80% epiboly stage of gastrulation, expression is higher dorsally than ventrally (PubMed:19216761, PubMed:22406073). Expressed in the paraxial mesoderm, posterior lateral mesoderm and adaxial cells at the end of the bud stage (PubMed:19216761, PubMed:22216300). Expressed in the segmental plate and ventral mesoderm during early gastrulation and early somitogenesis (PubMed:25371059). Expressed at the posterior dorsal midline at the three-somite stage and extends to the anterior region along the notochord, and to the trunk somites and cells lateral to them in the 24 hours post-fertilization (hpf) (PubMed:22406073). Expressed in both dorsal and ventral fast muscle cells in the late stages of segmentation (PubMed:19216761). Expressed in the hindbrain, a subpopulation of spinal cord interneurons, hypaxial muscles and in migrating muscle cells giving rise to the hyoid muscles and pectoral fin muscles at 24 hpf (PubMed:25371059). Expressed in the neural tube and hindbrain at 36 and 48 hpf with additional expression in the pectoral fin bud and fin muscles at 48 hpf (PubMed:19216761, PubMed:22406073). Expression is lost from the trunk at 48 hpf (PubMed:19216761)
+Expressed early during conidial (dormant spores) differentiation
+Strongly expressed in Rathke pouch in seven-week-old embryo
+Expressed in 8.5 dpc, 9.5 dpc, 10.5 dpc and 11.5 dpc embryos
+Expression in fruit is ripening-related, with highest expression levels detected in turning stage and red fruit
+Highly expressed 0.5 days after subculture (DAS). No expression was detected at 5 DAS and then expression was highly induced between 11-20 DAS
+Expressed during the whole cell cycle
+According to PubMed:1378265 and PubMed:15183309, down-regulated during embryonic development, but according to PubMed:10597293, expression does not change during embryonic development. Between 10 dpc and 12 dpc, expressed in heart and spinal ganglia. Between 13.5 dpc and 16.5 dpc, strongly expressed in spinal and sympathetic ganglia, neural epithelium of the retina, oral and olfactory epithelia and thymus
+Expressed in the brain and parts of the peripheral nervous system (at protein level) (PubMed:10037607). Expressed from embryonic stage 13 in the differentiating nervous system in a subset of glial cells, including longitudinal glia and segmental boundary cells (PubMed:10037607)
+Expressed in fetal spleen, liver and thymus
+In embryo, expressed in developing neural structures as well as in heart, branchial arches and limb buds. First expressed at stage 7 in the neural plate with lower expression in the midline. By stage 9, expressed through out the developing neural tube with lower levels in the future posterior mesencephalon and rhombomere 3. In anterior regions, highest expression in the dorsal neural tube and, more posteriorly throughout the closing neural tube. Also expressed in the ectoderm flanking the neural tube. In the developing brain, expression found in the presumptive forbrain. By stage 12, expression restricted to the dorsal prosencephalon, hindbrain and posterior neural tube. In the placodes, first expressed at stage 11, in the otic placode. By stage 15, expressed in the olfactory and epibranchial placodes. In facial primordia, expression found at stage 2,0 throughout the ectoderm. By stage 24, high mesenchymal expression in a small region of the posterior maxillary primordia, and in the lateral region of the mandibular primordia. By stage 28, expressed in a subset of muscles, including the intermandibularis muscle and the muscle medial to the eye. In the developing trunk, expression found throughout the dermamyotome in the more developed somites. By stage 20, expression restricted to the small region in the dorsal medial lip in all somites. In addition, also expressed in the ventral lateral lip of the dermamyotome that gives rise to the muscles of the limbs and body wall. During limb development, expressed between stages 20 and 30, in the proximal mesenchyme in association with developing muscles. Between stages 27 and 30, expression found in mesenchyme containing undifferentiated myogenic cells. In the developing heart, expression restricted to the myocardial and endocardial cell layers of the trabeculae in the ventricular compartment between stages 20 and 28
+Expressed at all developmental stages (PubMed:17574230). Highly expressed in the intestine at all developmental stages (PubMed:17574230)
+In roots, localized in elongation and root hair zones. In flowers, observed in carpels
+Becomes detectable at the second postnatal week in the cerebral cortex and hippocampus and at the third postnatal week in the cerebellum and olfactory bulb. The expression level is maximal during the third and fourth postnatal weeks and remains high during adulthood. Its expression is closely correlated with neuronal differentiation (at protein level)
+In skeletal muscle, expressed in differentiated myotubes but not in undifferentiated myoblasts
+During gestation, both hepatic and serum expression begins at day 9. Levels increased 8-fold in liver and 30-fold in serum by late gestation. Levels of isoform 1 and isoform 2 similarly begin at day 9 with isoform 1 expression reaching maximum levels by day 13, isoform 2 levels continue to increase until the end of pregnancy
+Constitutive expression of diptericin occurs in early pupae and in adults
+Expressed in larvae and adults. Expressed in dopaminergic neurons in L4 larvae
+Accumulates before mitosis with levels increasing in S phase and decreasing in M phase (PubMed:11389834). Weakly detected in cycling egg at the stage just before entry into M phase, but not detected in immature (stage VI), metaphase-I and metaphase-II oocytes, and cycling egg that has entered in M phase. Destroyed at every M phase during both meiotic cycles and during cleavage cycles (PubMed:15314241). Decreases at metaphase and completely disappears as cells exited mitosis. First observed at 4 h (S phase) reaching a peak at 7 h (G2 phase), and then a subsequent decrease from 9 to 10 h corresponding to early and late M phases, respectively (PubMed:17159919)
+In the embryo, expression initiates at 15.5 dpc in both the neocortex and hippocampus
+Expressed from embryogenesis to adulthood (PubMed:10412978). First expressed in the anterior region of comma stage embryos (PubMed:10412978). During embryogenesis, expressed in pharyngeal, hypodermal and neuronal precursors in the anterior body region (PubMed:10412978). During larval development, expressed in the pharyngeal-intestinal valve cells and neurons in the retrovesicular ganglion and the ventral cord (PubMed:10412978). Expressed in migrating QR neuroblasts with higher expression in migrating QR.a/ap cells than QR.p/pa cells (PubMed:23784779)
+In roots, mainly localized in apical zones, including root tips, in both endodermis and cortex tissues (PubMed:12369619). In the differentiated region where root hairs are present, localized in cortex, endodermis and xylem (PubMed:12369619)
+No differential expression during adipocyte differentiation
+Expressed in the forelimb buds, the branchial arches, the caudal presomitic mesoderm (PSM) and at the anterior and posterior of each somite boundary at 9.5 days postcoitum (dpc). Also expressed in the tailbud
+Expressed during early flower development. Not detected during germination
+Expressed in the actively growing young stages of Arabidopsis seedlings. When plants grew, however, expression was evident only in cotyledons, primary leaves, and hypocotyls. The activity decreased in the secondary leaves, being detectable only in vascular tissues. In the roots as well, expression was localized mostly in vascular tissues. Expression becomes highly active when floral shoots bolted, especially in the young or actively growing tissues of inflorescence stems. Continuously expressed during pollen development
+In the cerebral cortex, at birth, confined in the Purkinje cell layer (PCL) and in cerebellar nuclei. Not detected in the external germinal layer (EGL). At P5 and P10, predominantly found in the PCL and internal germinal layer (IGL). Not detected in the EGL. At P10 and P20, up-regulated. At P20, expression similar to that of the adult cerebellum
+At 12.5 dpc, it is present in the mandibular as well as maxillary components of the first branchial arch. Also detected in the thoracic body wall adjacent to the heart. At 13.5 dpc, it is detected in the mesenchyme lateral to Meckel's cartilage. Pronounced expression is observed in the perichondrium of the humerus, ribs, and scapula. At 14.5 dpc, it is detected in the mesenchymal condensations lateral to Meckel's cartilage, in the perichondrium surrounding the central cartilaginous elements of the vertebra and also in the dermal mesenchyme. At 15.5 dpc, it is expressed in the perichondrium/periosteum of the long bones (i.e. femur, tibia, and fibula), some of the flat bones at the base of the skull (i.e. sphenoid bone), ribs, clavicle, and vertebrae. Also detected in the intramembranous bones of the maxilla and mandible (alveolar bone) and a strong expression is observed in sagittal sections of the subcutaneous muscles or panniculus carnosus of the thorax, trunk, and head/ neck (platysma muscle) region. Very little expression is detected in the major parenchymal organs (with the exception of the large bronchi of the lung). Its expression is prominent in the developing mouse skeleton, particularly in the perichondrium/periosteum of cartilage/bone, and is also found in other specialized connective tissues such as tendon, sclera, the connective tissue sheath surrounding muscle and dermis. In the sclera of the eye it is first detected at 15.5 dpc and stronger expression was detected at 17.5 dpc
+Primarily detected between 11 dpc and 12 dpc. Expressed at 12 dpc in the dorsal region of the developing nasal cavity and in the mesenchyme located between the olfactory epithelium and the presumptive olfactory bulb. In the medulla oblongata, first detected at 17 dpc. In the area postrema and the nucleus tractus solitarius expression peaks at P20 and then decreases slightly
+Etiolated seedlings
+Accumulates progressively at very low levels during fruit development
+Specifically expressed in liver-infective sporozoites. Not expressed in blood stages
+First detected at 9.25 dpc, specifically in the mesonephric vesicles. By 10.0 dpc expression is also observed in the rostro-lateral mandibular mesenchyme immediately adjacent to the maxillary processes. In the developing limb buds it is expressed in a unique mesenchymal domain and the onset of the expression follows a distinct dorsal to ventral developmental time sequence beginning in the forelimb and then in the hindlimb. It exhibits a dynamic expression pattern during craniofacial development, in the mandibular and maxillary processes as well as the developing palate. It is also expressed at sites of epithelial-mesenchymal interactions during tooth and kidney development
+Induced in G1 phase, accumulates at G1/S transition, and degraded in late mitosis following ubiquitination and degradation by the APC(CDH1) complex
+Expressed from the one-cell stage throughout embryogenesis (at protein level). Expressed fairly ubiquitously up to the gastrula stage, then restricted mainly to the nervous system later in development
+Detectable in lateral root development when they reach 10 mm long
+Detected during early choriogenesis and is not detected after follicle 6. Maximum abundance in follicles 4 and 5
+Expressed in one-, two- and four-cell embryos and through early morphogenesis (at protein level) (PubMed:11566890, PubMed:18854162). Also expressed in oocytes, and until at least 12-cell stage in embryos (PubMed:18854162)
+Expressed only in testicular germ cells after meiotic division. Expression was first detected at the age of 4 weeks
+Detected in whole embryos after 11 days of development. Detected in embryonic head. Highly expressed in newborns and up to 7 days after birth. Expression is decreased after 14 days
+Expressed in fore- and hindbrain structures from 13 dpc onwards
+Expressed in five or six cells (per hemisphere) in the frontal area of the brain in day 4 fifth instar larvae
+Expressed in the floor plate throughout the period of commissural axon pathfinding (PubMed:9484836, PubMed:10704386). In myogenic progenitor cells, highly expressed during early development (11.5 dpc) and progressively repressed as developments proceeds (PubMed:27446912)
+Detected at the two-fold embryo stage. Expressed in the intestine during L1 to L3, followed by expression in uterine seam, gonadal sheath cells and spermathecal-uterus valve at L4
+Not detectable in undifferentiated preadipocytes and myogenic cells. Accumulates at high levels during the terminal stages of the differentiation process
+Developmentally regulated
+In testis, expression detected at 12.5 days post coitum (dpc) and peaking at 14.5 dpc, with expression dropping to low levels at the day of birth. After birth, levels increase 4-fold to a peak at 10 days post partum (dpp) and fall again thereafter
+All developmental stages
+Expressed on chromosomes from early prophase until late anaphase
+First detected in neurula (stage 16/17). Highest levels in whole tadpole found around stage 47/48. In the intestine, increased levels are found during metamorphosis (stages 58-64). Low levels expressed in hindlimb until stage 66 after which, levels dramatically increase. In the tail, a constant high level of expression is found throughout metamorphosis
+Expressed throughout embryonic development, with much higher expression after day 15, when many organs including the kidney are undergoing extensive branching morphogenesis
+Isoform b: Enriched cortically both in the anterior portion of the one-cell zygote and at the blastomere boundary in two-cell embryos. Isoform c: Localizes to nonpolarized cellular cortex in oocytes and early one-cell zygotes and anterior cellular cortex in one-cell embryos subsequent to pseudocleavage. Present at the interface of the AB and P1 cells. Undetectable by the four-cell stage
+Expressed from the late gastrulation/early segmentation stage in the midbrain/hindbrain boundary (MHB) and in the posterior trunk region. Subsequently, its expression is restricted in the tail bud region and notochord. At 22 hrs after fertilization (hpf), high level expression is observed in the notochord and MHB. The tail bud expression declined by 30 hpf. Notochord expression declines at 48 hpf and disappears by 72 hpf although low level MHB expression remains until 72 hpf (PubMed:19874420)
+Expressed in the regenerating spinal cord but not in the adult one
+Expressed both maternally and zygotically. Expressed ubiquitously throughout development. Expression is high during embryogenesis but decreases 30-fold in adult flies (at protein level)
+Accumulates in seeds after imbibition (PubMed:23893219). Mainly present in elongating or expanding tissues (PubMed:21558309). Strongly expressed in the aerial portions and root tips of seedlings. Present in stem and leaf epidermis, including the trichomes, leaf mesophyll cells, and stem cortex and xylem. In flowers, observed in the upper portion of the styles, anther filament, and veins of the sepals and petals, silique walls and developing seeds (PubMed:23893219)
+Expressed at constant level, without strong circadian variations. Its amount nevertheless oscillates along day and night cycles in the termini of dorsally projected axons of LNvs
+First detected in early flower primordia and during stamen development. Later expressed in anthers and in pollen
+Expression restricted to vegetative phase
+Increasing expression in retina from 15 dpc to adulthood: expressed at P8 when photoreceptor outer segments are in active stages of elongation; elevated expression at P10 in the developing IPM and at P15 in the region adjacent to the retina pigment epithelium (RPE). From P18 to P35, more homogeneously present in the IPM surrounding both cones and rods
+Expressed in prestalk, prespore and spore cells. Expression of mRNA starts at 8 hours of development when loose aggregates form and remains constant until the onset of culmination at 20 hours when a significant increase is observed
+Detected in fully expanded leaves of 8 to 34 month old plants, levels peak in autumn. Also present in developing leaves (10-60 days old) of adult plants
+Expression is low during embryogenesis and increases around postnatal day 21
+Expression primarily in adults
+At 11.5 dpc and 13.5 dpc strongly expressed in the soft connective tissue of the face and trunk, and in the invertebral tissues. Low levels are found in brain and neural tube. Low levels are found in 13.5 dpc lung, kidney, eye lens and in vertebral cartilage located cranially. In 11.5 dpc hindlimbs weakly expressed by the mesenchymal cells surrounding the perspective cartilage-forming regions. In 12.5 dpc hindlimbs strongly expressed by cells enveloping the chondrogenic primordia of the digits, metatarsals, tibia, and femur, and the soft connective tissue in the interdigital tissues. In 13.5 dpc hindlimbs expression is maintained in the intergigital tissues located proximally and is found in some chondrocytes in the stylopod and in mesenchymal cells surrounding the cartilage in the autopod and zygopod. In 13.5 dpc forelimb strongly expressed in the pre-hypertrophic and hypertrophic regions of the humerus, radius, and ulna. Expression in hypertrophic chondrocytes is maintained at 14.5 dpc and is not detectable at 15.5 dpc. At day 14.5 dpc also expressed by chondrocytes in the cartilage forming the carpals and tarsals and by mesenchymal cells in the process of condensing to form tendons. In 13.5 dpc hindlimbs expressed in some myoblasts in the proximal myogenic region. In older limbs expression is maintained in the myotubules
+During seed coat development, expressed from linear cotyledon to mature green stages, with a peak at the bent cotyledon stage
+Expressed from day 16 dpc, but accumulation was primarily postnatal with maximal steady state levels reached at postnatal day 10
+Expressed in gametocytes; expression is higher in male gametocytes compared to female gametocytes (at protein level) (PubMed:29866905). Expressed in zygotes and, to a lesser extent, in ookinetes (at protein level) (PubMed:29866905). Not expressed in schizonts (PubMed:29866905)
+Expressed in the slug stages (at protein level). Expressed at a relatively low level in growing cells. Accumulates during the first few hours of development, to reach a plateau during aggregation
+Circadian-controlled expression
+From 9.5 dpc to 12.5 dpc, expressed in the developing central nervous system, dorsal root ganglia, eye vesicles and limbs. At 9.5 dpc, expressed in the developing forebrain, midbrain, hindbrain neural folds and spinal cord. When the embryo developed to 10.5 dpc, expressed in the telencephalic vesicles, midbrain, hindbrain, and spinal cord and is detectable in the dorsal root ganglia region and somites. Similar expression patterns at 11.5 dpc and 12.5 dpc, with significant expression in the telencephalic vesicles, midbrain, hindbrain and spinal cord
+Expressed both maternally and zygotically. Zygotic expression is highest in late larval development
+Expression changes dramatically during cochlear development. Expression is detected at 11.5 dpc in otocyst and increases in the SG neurons after 18.5 dpc. Also detected in the lumen side of all cells forming the vestibular cavity and at the top of the macula of saccule and utricle. Before birth expressed by epithelial cells facing the endolymphatic space. Post-natally expressed by cells in the apical turn of the cochlea, while expression on the lumen side of the membranous labyrinth decreases. Expression shifts gradually toward the top of supporting cells and the spiral limbus. Also expressed by vestibular ganglion neurons. Restricted to the SG neurons in the mature cochlea (at protein level)
+Maternally and zigotically expressed. Uniformely distributed in embryos
+In brain, expression is highest in neonates and declines to approximately 50% in adults. Isoform 2 is the predominant isoform in neonates with isoform 1 being barely detectable at this stage. Levels of isoform 1 increase with age, with the most pronounced increase between postnatal days 10 and 20
+Expressed throughout all stages of postembryonic development. Observed in the intestine and in cells in the tail during L1, L3 and L4
+Four-repeat (type II) TAU/MAPT is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) TAU/MAPT is found in both adult and fetal brain
+Expressed in the early embryo, in the mesodermal lineage derived from the MS blastomere
+Increased expression from 18 dpc to adulthood seen in cortex and hippocampus (at protein level)
+Detected at low levels on day 6, increases gradually to day 11 and then dramatically rises well into the adult stage
+Expression begins after the mid-blastula transition, peaks during gastrulation and is completely extinguished at the end of neurulation, before reappearing in swimming tadpoles
+At day 11.5 dpc, expressed in maxillary process. at, 14.5 dpc, also detected in the stomach and at 15.5 dpc expressed in developing bones. During embryogenesis, also expressed in lung, cartilages, liver, brain and peripheral nerves (PubMed:14709716). In kidney, isoform 2 is expressed at birth and isoform 5 at 2 weeks of age. In intestine, isoform 5 is expressed at 13 dpc and isoform 2 at birth. In cerebellum, high levels of isoform 2 at 17 dpc are down-regulated to moderate levels in newborn mice and undetectable levels in adult mice. Similarly, moderate levels of isoform 2 expressed in cerebrum of 17 dpc are gradually down-regulated to undetectable levels in adult mice
+Expressed at 12 dpc in ciliated structures, including maturing (stages X and XI) spermatids, the connecting cilium of the retina and bronchial epithelial cells. At 14 and 16 dpc, detected in the telencephalon, with prominent expression at the developing ependymal cell layer and the olfactory epithelium
+Expressed in 5-12 hours embryos
+Detected from late pupal stage onwards
+Expressed both maternally and zygotically. First detected at the syncytial blastoderm stage
+Strongly expressed in vegetative cells, and a steady decrease during the differentiation cycle
+Adult expression levels are reached by day 20 after birth
+Expressed in larva, pupae and adult
+Expression is enhanced between postnatal days 10 and 15
+Restricted expression to the primary root in young seedlings. Later detected in hypocotyl, leaves but with the strongest expression in the root system
+First detected at tailbud stages. At stage 27, appears in the pronephric duct, trunk and tail bud. In stage 30-40 embryos, expression extends rostrally and caudally to include neural crest cells at all axial levels
+The expression increases with successive stages of embryonic development
+Expression is first detected at 8.5 dpc, increases to highest levels at 14.5 dpc and remains elevated through the newborn stage. Expressed in developing limb buds and tail buds starting from 9.5 dpc. At 9.5 dpc, expression is prominent in the entire embryo, with the exception of the primordial cardiac sac. At 10.5 dpc, expression reduces to the neuroepithelium, branchial arches, spinal cord, somites, limb, and tail buds. At the onset of central nervous system development, the neuroepithelium shows a prominent staining between 9.5 dpc and 10.5 dpc. Thereafter, expression is unevenly distributed in a progressively thinner layer along the inner surface of the ventricle. Expression is intense at the bumps corresponding to the nascent limb buds around 10.5 dpc. Shortly thereafter, as the limb buds emerge from the body and expand, expression declines and is limited to the most distal surface at 12.5 dpc. At 13.5 dpc it is no longer possible to identify expression in either the developing nervous system, the limb or the tail buds. From postnatal day 10 (P10) to the adulthood, expressed in cells lining the wall of the four ventricles of the postnatal brain (PubMed:25883935)
+First expressed in blastomeres at the two cell stage of embryogenesis (PubMed:19084000). Also expressed in germline-specific P granules of early embryos (PubMed:19084000)
+Expressed during the differentiation of microsporocytes and tapetal cells. Also expressed in the meiocytes and young pollen grains until pollen mitosis II
+Expressed during vegetative growth and throughout development. Levels decrease after aggregation and are lowest during culmination
+Expressed during the whole life cycle
+Vitellogenin is detected in stage 1 of the ovarian cycle and protein levels increase to reach a maximum in stage 3. Thereafter vitellogen levels in the ovary decrease gradually. Vitellin is detected at low levels in stage 1 of the ovarian cycle and protein levels increase steadily in stages 2 through to 4
+Expression is low during embryogenesis and becomes up-regulated in some adult tissues including heart and skeletal muscle
+Developmentally regulated, appearing in inner-hair cell stereocilia during final stages of elongation
+In T-cells, expressed 20 minutes following activation
+Expression decreases with the age of the seedlings
+Expressed throughout plant development, with a slight reduction during senescence
+Expressed in the embryo throughout development
+Maternal protein synthesized during postoogenic maturation and persisting throughout embryogenesis
+Specifically expressed in starchy endosperm of developing seeds from 5 to 30 days after flowering (DAF)
+Detected at high levels in lung during the late fetal and postnatal period and at lower levels in adult
+Low expression in young leaves, but high expression in older leaves
+Detected in intestinal enterocytes at embryonic day 17
+Expressed throughout panicle development. In mature spikelets, present at low levels in anthers and palea/lemma, and barely detectable in the ovaries and lodicules
+Detected in embryonic eye lens; levels increase steadily from 10.5 dpc onto birth and continue to increase during the first three weeks after birth
+This protein is apparently expressed only in developing seeds
+Expressed at all stages of seed germination. Expression decreases markedly from day 1 to day 15 after imbibition
+During seed development, expressed from 5 to 20 days after flowering (DAF), with a peak at 10 DAF. Not expressed in mature seeds
+Expressed in a restricted region of the posterior hypothalamus from 10 dpc. Detected in the head region from 12.5 dpc to 14.5 dpc. Expression is down-regulated by 15.5 dpc
+Nearly restricted in the vascular tissues during the caryopsis development. Observed in maturating caryopsis 2 days after flowering (DAF)
+In the testis, expression is detected from the first day of birth, increases steadily in the first 3 weeks of life, decreases around day 28, increases at day 35 and is stable between 35 and 56 days. Highly expressed in spermatogonia and is also observed in primary and secondary spermatocytes but less so in spermatids (at protein level)
+Expressed at low levels in anthers from closed buds, with expression in the tapetum at the stage before microspore release from tetrads
+At embryonic stage 16.5 dpc detected in intestinal enterocytes, pancreatic acinar cells, and cochlear hair cells (at protein level). In newborn mice, detected in brain, kidney, liver and intestine (at protein level)
+During anther development, expressed in the tapetum at the early-stage and middle-stage of pollen differentiation
+During embryogenesis, detected in all cells from the early octant to the torpedo stage
+At globular stage, expressed throughout the embryo, endosperm and surrounding maternal seed tissue. From the heart-stage, expression restricted to the embryo and the funiculus
+Expressed in metaxylem and phloem of parenchyma cells and in sclerenchyma cells of developing leaf blades
+Fluctuant expression pattern with four peaks during development, and then it increased rapidly during ripening
+Expressed both maternally and zygotically, during and after gastrulation. Expressed in neurulating embryos at the neural tube, the optic tissue, the developing midbrain and the pharyngeal pouches. Expressed at the tailbud stage in the primitive eye field, the optic recess, the optic cup, the retina, the tectum, the dorsal neural tube and the branchial arches
+Down-regulated in germinating seeds between 3 and 5 days after germination. Down-regulated in flowers from 5 days after pollination
+At 15.5 dpc, predominantly expressed in skeletal muscle tissue, including diaphragm, and to a lesser extent in the central nervous system
+Up-regulated in the early phase of bone regeneration
+Expressed in the developing cerebellum, pons, medulla oblongata and spinal cord. In embryonic brain, expressed in a subset of postmitotic neurons generated posterior to the midbrain-hindbrain border. In the developing spinal cord, selectively expressed in dorsal horn interneurons
+Expression in lung is low at 17.5 dpc fetal mice and increases progressively into adulthood
+Up-regulated during epidermal differentiation
+Expressed in the developing mesocarp from 13 weeks after flowering until veraison, when the color of drupes turned from green to black
+Expression is first detected in the embryo after 9 dpc. In the embryo, expression is found in restricted regions of somite derivatives, limb anlagen and cranio-facial mesenchyme. In the fetus, it is additionally expressed in mesenchymes apposed to precartilaginous condensations, at many interfaces to budding epithelia of inner organs, and weakly in muscles
+Most abundant in midgestation embryos (day 9.5)
+Expressed during the asexual blood stage, probably in gametocytes
+Expressed in female gametophyte throughout embryo sac development. During pollen development, expressed from meiosis up to the second pollen mitosis, but not at mature (three nucleate) stages
+First expressed in the inner cell mass (ICM) of embryos at 18 hpf (hours post fertilization) and continues to be expressed in the developing embryo until at least 48 hpf (PubMed:18941117). Expressed in the developing hematopoietic system, at 24 hpf and circulating primitive erythrocytes at 48 hpf (PubMed:11535513, PubMed:18941117). Expressed in the pronephros, and in circulating definitive erythrocytes in the heart lumen and vessels of the tail at 8 dpf (days post fertilization) (PubMed:11535513)
+Highly expressed in mitotic cells (at protein level)
+Only present in a-cells (classes I and IV)
+At 10.5 dpc expressed in the mandibular arches, heart and limb buds
+Widely expressed during embryonic development. Primarily detected within the neuropithelium, spinal ganglia and peripheral nerves
+Expressed during vegetative unicellular growth
+Expressed in a ring surrounding the center of meristems extended in the cortex of developing stems and older pedicels. Present in all developing floral organs, especially in anthers and gynoecium (mainly in ovules). Observed in anthers at stage 2 in the archesporial cells. At stage 3, localized in the primary sporogenous and primary parietal cells. Subsequently preferentially expressed in the sporogenous cells at anther stage 4. Later restricted to the tapetum and pollen mother cells (PMCs) before disappearing progressively
+At 8.5 dpc, it is detected throughout the neuroepithelium (PubMed:17589504). At 11.5 dpc, it is highly expressed in the ventral-most part of the spinal cord, the encephalic vesicles, the neural retina, the limbs and the dorsal root ganglia (PubMed:17589504). Later, it is expressed in the entire developing nervous system as well as in other tissues (PubMed:17589504). In brain, strong expression is observed in the cortex, hippocampus and striatum of postnatal brain (PubMed:17589504)
+Expressed, beginning at 9.5 days of gestation and at 10.5 days in regions destined to become skin. In adult animals, expression is predominantly in skin (PubMed:7937772). Expression is significantly increased during brown adipocyte differentiation (PubMed:28784777)
+In the estrous cycle, expression and activity are highest in the luteal phase
+Peak of expression at mitosis
+Expressed in embryonic stem (ES) cells and in inner cell mass (ICM) of the blastocyst
+Remains active in dormant M.tuberculosis
+Expressed in anthers from the bi-cellular to the tri-cellular pollen stage
+First detected 3 days after birth
+Expressed in apical meristems in transition to flowering
+Highly expressed at early stages of root development
+In seedlings, present in roots, except in tips, leaves and petioles. In inflorescence and flowers, accumulates in sepals, carpels (e.g. styles and floral nectars) and stamens (e.g. filaments and vascular tissue of anthers), but not in petals or stigma
+Highest expression in endosperm at 7 days after pollination and in flag leaf at 14 days after heading
+Detected in fully expanded leaves of 8 to 34 month old plants, levels peak in autumn. Also present in developing leaves of adult plants, detected in 10 and 17 day old leaves but not in 25, 40 or 60 day old leaves
+Expressed in the growing regions of coleoptiles, internodes and leaves
+Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5-16.5 dpc
+Detected in the placenta from day 11 of gestation onwards (PubMed:19503832, PubMed:23759217). Expressed in the conceptus at the pre- and peri-implantation stages (gestational days 11-21) (PubMed:19503832). Expressed in the extra-embryonic membrane at the post-implantation stage (gestational days 27-33), although expression appears to decline temporarily at gestational day 27 (PubMed:19503832). Expressed in cotyledon from early to late gestation (gestational days 60 to 250), with highest expression levels at gestational day 60 and declining expression thereafter (PubMed:19503832, PubMed:23759217). Also expressed in intercotyledon from gestational day 60 onwards, reaching maximum expression levels during late gestation (PubMed:19503832, PubMed:23759217). Expressed in caruncle from early to late gestation, reaching maximum expression at the late gestation stage (PubMed:23759217). Has low expression in intercarunclar tissue during early gestation, but expression levels increase by mid gestation and remain high during late gestation (PubMed:23759217)
+Absent from the primary root (PubMed:23370719). Induced during lateral root formation after the emergence of the primordium and in mature lateral roots (PubMed:23370719). Expressed homogeneously across the cotyledon (PubMed:23370719). In leaves, expressed in the whole lamina, with a stronger signal in the outer part of the leaf (PubMed:23370719). Higher levels in younger leaves and fades out as leaves expand (PubMed:23370719). Observed in the stem and sepals, and in the gynoecium of the developing flowers, and later in siliques (PubMed:23370719). During seedling gravitropic response, restricted to the epidermis and cortex and enhanced at the lower side of the reoriented hypocotyl (PubMed:22421050)
+Widely expressed in embryonic and neonatal skin
+Expressed at the newly excysted juvenile stage
+Expressed during the asexual blood stage including in trophozoites, schizonts and free merozoites (PubMed:21752110). Expressed in gametocytes (PubMed:21752110). Expressed during the liver stage (PubMed:21752110)
+Expressed during early embryogenesis. Detected apically in the basal cell lineage resulting from the first zygotic division. At the 32-cell stage, localization shifts to the basal side of the cells in the developing embryo
+Both isoforms 1 and 2 increase up to 7 days after sowing, but then decline
+Widely expressed in fetal tissues with high expression in fetal heart
+Readily detectable during gestation, reaches adult levels by 17-20 days gestation, rises markedly at 7 days of age but falls to adult levels by 14 days and remains at that level throughout the suckling-weanling period
+Appears for the first time during follicular development in the fusiform granulosa cells of recruited primordial follicles and continues to be present in granulosa cells up to the antral stage
+First expressed at 8.0 dpc in the developing heart and throughout development. By 8.5 dpc, it is expressed in the lateral neural folds of the hindbrain and extends anteriorly and posteriorly to eventually cover the dorsal neural tube from the isthmus to its caudal end. From 9.5 dpc, it is expressed in the dorsomedial telencephalon. In the hindbrain, it is confined to trigeminal motor neurons and to migrating facial branchiomotor neurons. In the peripheral nervous system, it is expressed in cranial and in dorsal root ganglia. Also expressed in the developing eye and in the nasal placode
+Expressed throughout cortical development: present throughout the cortical wall at all of these ages, with strong expression in the early ventricular zone and the embryonic preplate/cortical plate (PubMed:27871306). Expressed in the developing limb: expressed in the forelimb bud and somites at 10.5 dpc, as well as in the apical ectodermal ridge (AER) (PubMed:30116001). Ubiquitously expressed throughout the embryonic forelimb at 10.5 dpc: expressed in the dermomyotome and sclerotome divisions of the somite (at protein level) (PubMed:30801883)
+Can be detected in regions including primordial retina and neuroepithelium by embryonic day 2 (2dpc). At 3 dpc, expressed in the nasal retina and pigment epithelium as well as in the telencephalon, and at 7 dpc is expressed in retinal ganglion cells. Levels begin to decline from 4 dpc and almost disappear by 10 dpc
+Expressed in early onset of sporulation
+Expressed at low levels early stages of floral development (e.g. small bud, medium bud and tube expansion), but accumulates at higher levels at later stages of flower development (e.g. anthesis and 2 days post-anthesis) (PubMed:17241449, PubMed:20543029). Following fertilization by pollen (pollination), a rapid ethylene biosynthesis in the stigma, style and ovary, and later in the corolla, lead to a reduced expression and a subsequent decrease of volatile emission (PubMed:17241449)
+Abundant in early stages of oogenesis. The expression is rapidly reduced between meiotic maturation and fertilization stages
+Isoform 1-CRR is expressed in embryos, larvae, pupae and adults
+Postnatal expression in the testis is elevated at the onset of pachytene (day 14)
+Increases around the time of ovulation and remained elevated in the developing corpus luteum
+Expressed in embryonic and postembryonic neurons, including AVKR and AVKL interneurons (at protein level) (PubMed:10648229, PubMed:16183052). Expressed in the AVA, AVB, and AVE bilateral interneuron pairs, the RIC bilaterally-paired interneurons, SIBD and either SIBV or SMBV neuron pairs, M4 motorneuron, and the unpaired DVA interneuron (at protein level) (PubMed:16183052). Expressed dynamically in two non-neuronal cell types during larval development, paired distal tip cells (DTCs) of the hermaphrodite somatic gonad of L2 through L4 stage larvae and two pairs of vulval cells in L4 hermaphrodite larvae (at protein level) (PubMed:16183052). Expressed in the pairs of CEPD and URX sensory neurons, three pharyngeal neurons (M1, MI and probably M5), two pairs of ring interneurons (including the RIC pair), five neurons in the retrovesicular ganglion (including SABD and the pair of SABV neurons), a single neuron in the preanal ganglion and a single neuron in the dorsorectal ganglion of the tail (PubMed:10648229). Not expressed in either of the HSN or PVQ neurons, or in the PVPR neuron at any stage of development (PubMed:10648229)
+Expressed throughout the life cycle with a two-fold decrease in amastigotes (LPG is 1000-fold less abundant in amastigotes than in promastigotes)
+Expression begins during late embryogenesis and continues in larvae and adults
+Low levels in 0-4 hour embryos with strong expression in late embryos at 12-24 hours and during larval development. Expression decreases during pupal development and increases again in adult flies with heads showing higher levels than bodies
+Developmentally regulated. Expression during kidney development increases around 8 fold from 11.5 dpc and adult. Highest expression is found in the ureteric bud
+In 4-days-old seedlings, confined to the root meristematic zone and in young leaves. In roots of 10-days-old seedlings, also detected in lateral root primordia, and in the stele in proximity to the hypocotyl
+Undetectable in testis until postnatal day 18. Sharply up-regulated from postnatal days 18 to 21. This timeframe corresponds to the appearance of the first spermatids of the first wave of spermatogenesis just before initiation of elongation. Remains elevated in adult animals
+Expression starts in body wall muscles at the 1.5-fold embryonic stage
+First expressed in provascular cells, and upon vascular cell type specification becomes restricted to the phloem cell lineage
+During embryonic development, initially localizes within early hair germs, but rapidly shifts to a subset of cells at the interface of basal and suprabasal cells above and around the hair germ (PubMed:12445204). Expressed in hair follicles and in most cells in the spinous layer at birth (PubMed:11408584)
+At 7.0 dpc (early head-fold stage) expressed in perinodal region. At 7.5 dpc (late head-fold stage) expression begins to decrease in intensity on the left side and starts to be asymmetrically up-regulated on the right side of the node. By early 8.0 dpc (somitogenesis), highly expressed in the right side of the node. No expression seen in later stages of development
+Higher expression in lenses from pre-natal (1-5 months gestation) than those from postnatal (4-6 months) calves
+During the immediate postnatal period, the dorsal root ganglia express all isoforms whereas only the larger forms persist in the adults
+In the third-instar larval stage, expressed in a stripe of cells at the anterior-posterior (A/P) compartment boundary of wing cells (at protein level) (PubMed:35609633, PubMed:35037619). In the pupal wing, expression does not change during the first 8 hrs after pupation (AP) but then disappears from the A/P boundary and commences expression in the differentiating longitudinal veins (at protein level) (PubMed:35037619). Expressed both maternally and zygotically (PubMed:10903186). First detected during stages 8 to 10 of oogenesis (PubMed:10903186)
+Expression onset occurs between stage 10 and stage 13
+Progressive increase in roots from the leaf opened stage to the green fruit, red fruit and root growth stages, respectively
+First expressed in DRG neurons around embryonic day 11.5, and expression is maintained throughout adulthood
+Expression levels remain fairly constant during early fetal development. This is followed by a marked increase of expression levels during the final stages of organogenesis, with initiation of the rapid fetal growth phase before birth. At mid-gestation, strongly expressed in the central and peripheral nervous systems. Also strongly expressed in developing heart, with localization to cell-cell contacts and accentuated in intercalated disks perinatally. During late fetal development, expressed in many tissues including cartilage, bone, skeletal muscle, lung, intestine and skin. Not detected in endothelia of most blood vessels or the endocardium of the heart
+Mostly expressed in early stages of development
+Low levels of expression seen in 7-, 11-, 15- and 17-day embryos
+Expressed in the forming heart in the stage 9 embryo, in the myocardial trough, and then at stages 10 to 11, in the nondifferentiated mesodermal cells at the venous and arterial poles, as well as cells of the dorsal coelomic wall and ruptured mesocardium (at protein level)
+Expressed both maternally and zygotically. Expressed from stage I to stage III oocytes, with levels decreasing throughout oocyte growth. Expression levels then increase from unfertilized eggs through oocyte maturation
+Expression first detected at 8 hours post fertilization (hpf) in a circumferential pattern in the lateral mesoderm. At 12 hpf, still expressed in the anterior and posterior lateral plate mesoderm which is partly detached from the yolk at this stage. By 18-20 hpf, expressed in the cardiac ring and in a layer of lateral mesoderm surrounding the cardiac region, as well as in the posterior lateral mesoderm. At 24 hpf, expressed throughout the nascent cardiac tube and in bilaterally symmetric clusters of ventrolateral cells that condense to form branchial arch mesoderm which gives rise to jaw and pharyngeal bones. Expression continues bilaterally in the posterior lateral mesoderm. At 36-48 hpf, expressed in defined branchial arch mesoderm populations. At 48 hpf, strong expression throughout the heart tube
+Found to be developmentally regulated in the skin where it is expressed in the epidermal layer, excluding the dermis, at embryonic day 17.5 dpc but not in 10.5 dpc and 15.5 dpc. In the small intestine found toward the base of the intestinal villi from 17.5 dpc. In the pancreas, expression was detected from 17.5 dpc and no expression was found in the liver. Also expressed in osteoblasts of developing bone from 15.5 dpc
+Expressed throughout all stages of plant growth. Increased expression in leaves before the booting stage
+Detected at all stages tested, including the fertilized egg stage (at protein level). Present in the fertilized egg before mid-blastula transition, and is expressed ubiquitously at relatively high levels from gastrulation to mid-somitogenesis stages. At the 20-somite stage, expression starts to decrease in the notochord, but remains high in the head and central nervous system. This expression pattern persists until approximately 24 hours post-fertilization (hpf). At 48 hpf, expression is dramatically reduced in the posterior part of the body, and becomes restricted to the head area
+Highest levels observed in fruits 2 months post anthesis
+Expressed in male gametogenesis, during microspore development. Higher expression is found during microspore mitosis with a dramatic decline during pollen maturation
+During arbuscular mycorrhizal (AM) symbiosis with (AM) fungi (e.g. Glomus versiforme), accumulates strongly in cortical cells containing arbuscules
+Highly expressed at stage 9, then gradually decrease
+Initially detected at 9 dpc with expression present in the overlying ectoderm of the limb bud in the presumptive apical ectodermal ridge. Expression is also seen in the dorsal otic vesicle in the presumptive endolymphatic appendage. Neural expression is present in the forebrain and midbrain with a sharp boundary across the central midbrain. Expression is also seen in the hindbrain. A stripe of expression can be detected in the neural tube. At 10 and 11 dpc expression is restricted to the apical ectodermal ridge. Expression persists in the endolymphatic diverticular appendage of the otic vesicle the forebrain/midbrain and the ventricular layer of the central neural tube through these stages
+Present in infective larvae and adult stages
+Expressed from early development; required for aggregation prior to fruiting body formation and sporulation
+A maternally synthesized protein. Found in granules in the peripheral cytoplasm in the fertilized egg, it localizes first to the basolateral membrane, then to tight junctions after cingulin and ZO-1. Nascent tight junctions are in place by the two-cell stage. The maternal form is more highly phosphorylated than the form detected in later developmental stages
+Expressed in optic cup at stages 10-19 and in nephric tubules from stage 10 to 20 and more. Expression in interdigital space begins at stage 20
+Expressed in the marginal zone of mid-gastrulae, and in ventral and lateral sectors. At neurula stages, strongly expressed around the blastopore and in the pharyngeal endoderm, and more weakly expressed throughout the ventral half of the embryo. Transcripts are detected in the nervous system, particularly the hindbrain and spinal cord, and tailbud of tailbud stage embryos, with weaker expression in the anterior nervous system, otic vesicle, heart, and pronephric duct. Transcription is increased by BMP4 and decreased by Noggin and tBR, indicating that it is regulated by BMP signaling
+Strongly expressed in the cotyledons of embryos and of young seedlings (PubMed:21558309). In adult plants, present in anthers of flowers, in funicles of developing siliques and at the base of roots (PubMed:21558309)
+In synchonized cells transcribed (PubMed:8289276) and protein expressed (PubMed:8577742) only in predivisional cells (from 80 minutes) with a peak at 120 minutes, protein levels drop precipitously prior to cell division (at protein level)
+Broadly expressed at low levels at all stages
+In the lens, expressed from 15.5 dpc to maturity (PubMed:18396277). Expression increases during osteoclast differentiation (PubMed:27505886)
+Lima bean stage of embryogenesis into adulthood
+Observed in seedlings shoot apical meristem (SAM). Later present in the entire inflorescence meristem, and accumulates strongly in organ primordia. In flowers, expressed in the anthers and in the nectaries. Present in the paraclade junctions between the primary stem and axillary stems, especially at the base of the cauline leaf and the emerging axillary shoot
+Synthesized during maturation of epidermal keratinocytes
+The short form increases from the onset of gastrulation to swimming tadpoles and the longer form appears at the end of gastrulation, is present throughout the tailbud stages and then decline in tadpoles
+Expressed throughout development with low levels detected from 3-8 hpf and highest levels in developing brain and lens at 24 hpf. In the embryo, expressed in anterior neural plate and later in lens and pituitary cells. Detected in the forebrain, lens and pectoral fin buds at 24 hpf. Becomes restricted to the lens equatorial region by 48 hpf. Strongest expression detected in the diencephalon and pituitary at 48 hpf. Evident in the cartilage surrounding the mouth at 72 hpf, appearing in the iris of the eye, developing lower jaw and the branchial arches at 96 hpf and extending to developing musculature along the trunk. During lens development, exhibits widespread expression during the primary differentiation phase of lens formation and then restricted to the region of secondary fiber cell differentiation during the phase of lens growth. Expressed in both proliferating and early differentiating progenitor cells of the posterior tuberculum
+Expressed in late gastrulation and early neurulation
+Expressed at the comma, 1.5-fold and 3-fold embryonic stages in multiple cells including muscle and somatic gonad cells. In L1 larvae, predominantly expressed in specific muscles and somatic gonad cells, in L2 larvae predominantly expressed in muscles cells and in L4 larvae expressed predominantly in the developing spermatheca and more weakly in vulva muscle cells. Expression increases in the hypodermis in dauer stage larvae prior molting to L4 larval stage
+In stage 10 embryo, expression is seen in neural tube, and at lower levels in the notochord, epithelial somites, endoderm and splanchnic mesoderm. At stage 18, PTC is broadly expressed in the neural tube but excluded from the cells of the floor plate. At stage 32, expression occurs in the mesodermal cells of the gastrointestinal tract
+Expressed during the asexual blood stage including in trophozoites and schizonts
+Found at all stages of development in comparable quantities (at protein level)
+Expressed in the developmental stages from spermatocyte to spermatozoon
+Expressed in the neural tube closure, with strongest expression in the floorplate. Expressed in ciliated epidermal cells
+Accumulates in developing leaves
+Expressed during early postnatal brain development, especially in the caudate putamen and thalamic nuclei. Expression in the cerebral cortex, the hippocampus and the cerebellum is moderate to high at P5 and shows a stable expression throughout development. Isoforms 1, 2, 4 and 6 are predominantly expressed in cerebellum up to the age of approximately 3 weeks. Isoform 1 expression decreases during development of cortex but slightly increases in cerebellum
+Germinating seeds or mature leaves
+Present in self-renewing embryonic stem cells (ESCs). Does not increase significantly at the onset of differentiation
+Within 2 hours following conidial germination its level decreases rapidly and by 16 hours it is undetectable. Accumulates during the late stages of conidiation and is present in free conidia
+Expressed in male pig embryo between 21 dpc and 26 dpc. Not detected in 31 dpc embryos
+Expressed at low level in the ventral mesencephalon at 14 dpc. Highly expressed in the developing dorsal root ganglia (PubMed:9182803). Isoform 1, isoform 2 and isoform 3 are all highly expressed in the late embryonic development (15 dpc and 17 dpc) (PubMed:12829325)
+Expressed both maternally and zygotically (PubMed:29769531). Ubiquitous in embryos at the four cell stage (PubMed:30139971). Detected at the eight cell stage. Detected at low levels throughout the embryo at the six somite stage, with higher levels in the developing notochord (PubMed:29769531)
+Detected in embryos and larvae (at protein level) (PubMed:12876273). Expressed in larval imaginal disks (at protein level) (PubMed:11514618)
+Appears at the mesenchyme blastula stage
+First detected at 13.5 dpc, a time coinciding with the requirement of sympathetic neurons for NGF
+Expressed in brain and eye 24, 72 and 120 hours post-fertilization (hpf). At 72 hpf expressed in swim bladder and in pronephric tube. At 120 hpf expressed in brain, trabecular bar, eyes, otic capsule, stomach, gall bladder, gut and pancreas
+In cochlea hair cells, only isoforms 1, 2 and 4 are expressed at P5. At P24, isoforms 1, 2, 3 and 5 are expressed
+Expressed in the embryo at 16 dpc
+Expression in the liver during fetal development increases between day 125 and term, and rises further in the newborn, being highest in the adult liver
+Expressed in embryo between 7 and 17 dpc
+Expressed in dormant seed
+Expressed in embryo. During embryonic development, the form phosphorylated at 'Ser-2' of the C-terminal heptapeptide repeats is present only in transcriptionally active somatic cells
+Continuously expressed in all stages of development
+Expressed maternally and zygotically throughout development
+Detected at low levels in embryonic brain. Highly expressed 6 and 10 days after birth, when granule cell migration occurs in the cerebellum; expression in cerebellum is considerably higher than in brain cortex. Expressed at lower levels in adult cerebellum
+Expressed maternally. Zygotic expression is observed at neurula and tailbud stages. Widely expressed in the presumptive ectoderm during blastula, and in the dorsal structures during neurula and tailbud stages. At tailbud stages, strongly expressed in the ventral region of neural tube. Isoform 1 is expressed weakly at neurula and strongly at tailbud stage. Isoform 2 and isoform 3 are strongly expressed at the tailbud stage
+Expressed in all embryonic tissues at 10 dpc. Detected at 7 dpc (PubMed:18848646, PubMed:18929642). At 11.5 dpc, faintly expressed in the lens epithelium cells and in the anterior part of primary fiber cells. At 13.5 dpc, strongly expressed in the developing lens especially the lens epithelium cells and in the inner limiting membrane. Additionally, it is also expressed in ocular mesenchymal cells in the vitreous. At 17.5 dpc, expressed not only in the whole lens, but also in the inner neuroblast layer. In the lens, appears to be strongly expressed in the lens epithelial and at the posterior pole of the lens (PubMed:18929642)
+Accumulates during the pollen mother cell meiotic stage
+First expressed at the onset of gastrulation, approximately 100 minutes after cleavage of the zygote (at protein level) (PubMed:8951066). Expressed in both Q.a and Q.p neuroblasts as well as in their neighboring cells (PubMed:23946438)
+Highly expressed in the developing embryo. Expressed in developing brain from 10.5 dpc, with highest expression in the forebrain between 12.5 dpc and 14.5 dpc. Central nervous system expression persists throughout the postnatal period in the cortex, hippocampus, olfactory buld, and, to a lesser extent, in the cerebellum
+Expressed in the developing nervous system (PubMed:12403719). Expressed in head and tail neurons, nerve ring, ventral nerve cord, lateral neurons, CAN neuron, seam cells and vulva cells (PubMed:26903502)
+Expressed at low levels at all stages of development, with a peak of expression in the embryo and in the 2-day-old pupa. Detected in all wing cells of the 2-day-old pupa
+Expressed throughout development. Levels increase during aggregation (1-6 hours) and are then maintained until late culmination when they start to decrease
+Expressed in embryos from 9 days of gestation onward. In 12.5 dpc embryos, low and diffuse level of expression was observed in the peritoneal membranes and intestinal and craniofacial mesenchymes. By 16.5 dpc, expression is higher and exhibits a more restricted accumulation in primary ossified regions, perichondrium, joints, tendon, atrioventricular valve of heart, and in selected portions of the head
+Wide distribution of expression throughout embryonic development, most predominantly in the central and peripheral nervous systems. High expression in the ventricular zone of proliferating neurons at 13.5 dpc. Broadly expressed in late embryonic and early postnatal cerebellar neurons, including premigratory granule neurons of the external granule cell layer. Expression is maintained in neurons of the internal granule cell layer after migration is complete. Intense expression in Purkinje cells throughout development. A unique pattern of intense expression in irregularly spaced cell bodies that do not appear to correlate with known parasagittal stripes. Expressed in Bergmann glial scaffolds used by granule cells during early posnatal radial migration
+Up-regulated during xylem vessel element formation. Expressed preferentially in procambial cells adjacent to root meristem, especially newly proliferating cells derived presumably from pericycle
+Expressed in embryo at 7 day dpc onwards
+Found during embryonic development and in early differentiated states
+Expressed in the early developmental stages of embryos
+At 16.5 dpc, present in rib cartilage, choroid plexus epithelium and associated blood vessels, and developing oral and tooth germ epithelia (at protein level)
+Expressed in cells of the pi uterine cell lineage during the 8-cell stage of development
+Expressed in oocytes from stages I to III. Expressed in 8-cell embryo. Expressed in brain, eye, branchial arches and neural tube at 24 hours post-fertilization (hpf). Detected predominantly in the CNS, putative neural crest, the sensorial layer of the epidermal ectoderm and their derivatives until the tailbud stage
+Transcriptionally regulated increases in mRNA and protein levels at the time of weaning
+In roots, expressed in all cell types, including root hairs (PubMed:30309966). Also observed in the vascular bundles and tips of cotyledons, the base of true leaves, the ovarian stigma and pollen grains within the anthers, and the tip and base of the siliques (PubMed:30309966)
+Expressed in fetal liver and spleen
+Detected during gametophytic pollen development and constitutively expressed in embryogenic pollen
+Levels increase upon the initiation of development and are maximal during aggregation, decrease 2-3-fold and remain constant throughout the slug stage. A switch from ubiquitous expression in all cells during growth and aggregation in early development to expression restricted to cells found at the top of the mound during tip formation is observed (at protein levels). Encodes a 2.0 kb and a 2.2 kb transcript. The smaller one is expressed, at low levels, in vegetative cells, and the larger one during development. Ubiquitously found in early development and then restricted to the apical cells in developing aggregates
+Haustoria and rust-infected leaves. Also observed, in lower levels, in spores or hyphae formed in vitro
+Expressed both maternally and zygotically. During embryogenesis expressed only at transcript level. Expressed in larvae (at protein level), pupae and adults. Initial embryonic expression is maternally derived, then gradually decreases until third-instar larvae when there is a burst of zygotic expression. Most of the female expression is ovarian (at protein level)
+Expressed in all tissues except heart and skeletal muscle, from 10.5 dpc to 18.5 dpc
+Expressed in most cells of the cleavage stage embryo, apart from a few cells at the posterior pole, from the 20 cell stage to the 200 cell stage
+Expressed in the shoot apical meristem in a circular pattern preceding leaf initiation, but is not detectable in leaf primordia or mature leaves in normal plants. Rings of RS1 expression subtend leaf insertion sites in the shoot, and lateral organ primordia in inflorescence and floral meristems
+Expressed in developing siliques 13 to 15 days after pollination (DAP). In germinating seeds, expressed from 12 to 48 hours after imbibition with a peak of expression at 24 hours
+Expressed late in development coincident with the elaboration of mature synapses
+Barely expressed throughout flower development
+Expression decreases during seed development and embryo maturation
+Expressed from day 16 when pachytene spermatocytes are present
+Expressed in 10-somite stage embryos but not spatially restricted
+Probably maternally supplied, the zygotic expression becomes significative at 2.75 hpf and then decreases after 18 hpf but is still detected at 24 hpf (PubMed:26056731, PubMed:27235108). Highly expressed in the developing central nervous system from the presumptive telencephalon to the caudal tip of the spinal cord (PubMed:26232532)
+Highest level during early embryogenesis and then decreases in larvae, pupae and adults
+Expressed in the developing dorsal midbrain, the posterior portion of the mesencephalon and the retinal primordium of the optic cup. At 10 dpc, expressed in the temporal and nasal aspect of the retina and throughout the length of the dorsal midbrain. At 10.5 dpc this retinal pattern of expression persists, and extraneural sites of expression include the branchial region, limb buds and intestine. Also highly expressed in the alar mesencephalon and the rhombencephalic basal plate from 10.5 dpc to 14.5 dpc, and in the posterior third of the tectum and the presumptive gut wall. Also strongly expressed in the hindbrain, optic vesicle, maxillary and mandible process, paraxial mesoderm, developing digits and the umbilical cord
+Expressed in embryos from the one-cell developmental stage to the 3 days post-fertilization (dpf) larval stage
+Expressed during embryonic development, expression decreases at morula stage
+Expressed both maternally and zygotically. Expressed throughout all embryonic stages. Maternal expression persists during early cleavage stages. Expression levels decrease at the onset of gastrulation, increase at the start of neurulation and are then maintained throughout future embryonic stages
+Strongly expressed in the ventricular zone of the developing cerebral cortex
+At P02, in the organ of Corti, expressed in the stereocilia of outer hair cells and in the kinocilia of both outer and inner hair cells. Also concentrated at the cuticular plate level of auditory hair cells. However, before P07, expression in the inner hair cell stereocilia is very weak. By P07, in auditory hair cells, patchy expression detected along the length of stereocilia, but absent from the very tip. Later in development, detected in the stereocilia bundles and microvilli of sensory cells and also in the supporting cell bodies (at protein level)
+Expressed at late stage of anther development. Starts at the tetrad stage and reaches a maximum level at the late vacuolated-pollen stage
+Detected at 6.25 dpc in the proximal epiblast at the junction between the embryonic and extraembryonic tissue. Later expression is more restricted to the primitive streak and mesoderm extending to the distal tip of the embryo. Strong expression is found in both posterior visceral endoderm and epiblast at the prestreak, but switched to the mesoderm at late-streak
+Associated with differentiation in stratified epithelia of the skin, esophagus, intestine, and cervix, as well as in the prostate gland. Undetectable in undifferentiated basal cells, but expressed in differentiated luminal secretory cells (PubMed:11113115). Expressed in differentiated macrophages and granulocytes, but not their precursors (at protein level) (PubMed:11113115, PubMed:15285719). In testis, also associated with cell differentiation, with conflicting results. Expressed in spermatogonia and primary spermatocytes, but not in cells from later differentiation stages, including secondary spermatocytes, spermatids, and spermatozoa (at protein level) (PubMed:17164409). Not detected in spermatocytes, nor spermatids, and strongly expressed in spermatozoa (at protein level) (PubMed:11113115)
+Expressed in mother cell during sporulation
+Highest expression in roots 4 days after germination, then in apexes 7 days after germination
+Expression of isoform beta begins at the 1-2 somite stage, peaks at the 11-18 somite stage, and is maintained at a lower level in the adult kidney. Isoform alpha isn't expressed until the 4-somite stage, after which expression levels rapidly increase
+In nonelongating internodes, highly expressed in interfascicular fibers and xylem cells but not in parenchymatous pith cells. In elongating internodes, predominantly expressed in protoxylem vessels
+Expressed at all larval stages and is expressed at higher level in the adult
+Larval muscle isoform is found in the larvae and adults, the adult muscle isoform in adults only
+As early as 12.5 dpc to 16.5 dpc, intense expression is restricted to mesenchymal condensations, which form the different cartilage elements of the developing skeleton. At 12.5 dpc, strongly expressed in all vertebrae, heart ventricle, dental follicle, interdigital tissue, tongue and cartilages of the basioccipital bone, maxilla, mandible and the region of the future nasal septum. At 14.5 and 16.5 dpc, expressed in ribs, long bones, interdigital tissue, metatarsals, dental follicle, cartilages of the mandible and nasal septum as well as vertebrae with stronger expression in posterior vertebrae. At 16.5 dpc, also expressed in paw bones and, in vertebrae, the expression is limited to mainly columnar, proliferating chondrocytes. At 4 days postnatal, intense expression in nasal cartilages, hair, dental and vibrissa follicles
+Expressed in several epithelia from 9.5 dpc onwards, with expression levels increasing during development. From 14.5 dpc onwards, found in some neuronal cells as well
+Expressed from blastula stage, peak expression at late gastrula stage. Expression localizes in neural fold at neurula stage; in the dorsal region of midbrain, hindbrain and spinal cord at tadpole stage
+Expressed in spinal cord at 11 dpc. Expressed in precrossing commissural axons and growth cones of neurons that crossed the midline at 12 dpc. Expressed in axons coursing in the ventral and dorsal funiculus ar 13 dpc. Expressed in postcrossing axons at 15 dpc (at protein level)
+Expression increases from late blastula (stage 9) through gastrulation, ending by the time of blastopore closure (stage 13)
+In testes, expressed in spermatocytes at the pachytene stage (weakly in early pachynema and strongly in late pachynema), and its expression persisted thereafter throughout spermatogenesis
+In both developing female and male gonads, first detected at 12.5 dpc, expression increases until 16.5 dpc and then drops (PubMed:22069478). Divergence between male and female expression starts around 5 days after birth (PubMed:22069478). In ovaries, expression decreases and becomes hardly detectable in adult ovaries, while in testis, expression increases 5 days after birth and becomes strong in the adult (PubMed:22069478). In both males and females, expression is restricted to germ cells (PubMed:22069478). In developing male germ cells, highly expressed at the spermatocyte stage; has little or no expression in round spermatids, elongated spermatids or spermatozoa (PubMed:26358182)
+Accumulates when cells are arrested in G2; degraded as cells traverse mitosis
+Isoform A: Detected in all stages of development, with higher levels in the pupae (at protein level) (PubMed:10480936). Isoform B: Detected in all stages of development (at protein level) (PubMed:10480936)
+Trophozoite
+Constant expression throughout floral development
+Expression decreases with increasing age
+All stages of development. A larger transcript is restricted to the embryonic and early larval stages
+In flowers, mainly observed in the stamina and pollen sacs (PubMed:31053658). In mature leaves, restricted to hydathodes (PubMed:31053658)
+Highly expressed during early stages of embryo development. Decreasing expression during the embryo maturation
+In myogenic progenitor cells, not expressed during early myogenic development, appears during early formation of the satellite cell pool (from 12.5 dpc to 17.5 dpc), before being completely down-regulated during adquisition of satellite cell quiescence
+Associated with microsporogenesis and declines as mature pollen is produced
+Expressed in oocytes of the fetal ovary (PubMed:25542835). Expressed primarily with other SCMC components in the subcortex of oocytes and early embryos (PubMed:25542835). Expression is excluded from cell-cell contact regions after the 2-cell stage (PubMed:25542835)
+Almost ubiquitous, low-level staining at 12.5 dpc. At later stages (14.5 dpc, 16.5 dpc and 18.5 dpc), staining of the eye, inner ear, kidney, regions of the central and peripheral neural system, the gut and the ciliated epithelium of the nasopharynx, trachea and lungs is more pronounced. Expression in the mouse eye shifted during development from the ganglion cell layer to the photoreceptors. In adult eyes (P90), expression is limited to the photoreceptor cell layer
+Up-regulated during adipocyte differentiation in a 3T3-L1 cell culture model (at protein level)
+Mostly expressed at bolting, flowering and during seed formation
+Expressed at substantial levels in the dorsal pons at 18.5 dpc (PubMed:10234000). Expressed in Purkinje cells at P4, with expression becoming striped at P20 (PubMed:10234000). Expressed in the cerebral cortex from 18.5 dpc with a rostrocaudal gradient of expression becoming evident at P20 (PubMed:10234000)
+In the optic nerve, expressed more abundantly in the embryo than in the adult
+Expressed zygotically. During gastrulation, expression levels rise rapidly to peak at about stage 10.5. Following gastrulation, levels decrease slightly and then increase again during early tailbud stages, with expression continuing throughout embryonic development
+Detected in the forebrain, prospective midbrain/hindbrain boundary, tail bud, and neural keel and neural tube in the somitogenesis stages. Expressed in the pectoral fin bud, and the signal is restricted to the apical fold
+Expressed specifically in late stage spermatocytes. In the cerebellum, emergence of beta-2 isoform coincides with granule cells maturation and exhibits postnatal developmental increases. Expression is specifically reduced in weaver mutant
+In germinating seedlings, expressed in root, hypocotyl and cotyledon epidermal cells. By day 4, expression expands in the root endodermis and throughout initiating lateral roots. As the seedling matures, expression in the hypocotyl and cotyledons decreases and by day 14, expression is restricted to creases between the shoot meristem and its lateral primordia
+Expressed at relatively high levels in vegetative cells. The expression goes down at the 2th hour of development and increase slightly at the 8th hour time point
+Detected at the one-cell stage followed by a decrease in signal intensity at the two-cell stage. Detectable at higher level in the four-cell stage and expressed through the eight-cell, 16-cell and morula stages. Maximal expression at the blastocyst stage
+Expressed throughout oogenesis with particularly high levels in germ line stem cells and cystoblasts and decreasing levels in subsequent divisions. Around stage 8, remains detectable in nurse cells and oocytes and expression increases in follicle cells where it persists until late oogenesis, both in stretched cells and in columnar follicle cells (at protein level)
+High expression is detected in the oocyte that declines to a stable level from the 8-cell stage until 8.5 dpc
+Expressed during development of the posterior part of the body
+Expressed from 2 weeks postpartum (at protein level)
+Rapid decrease in leaves from the leaf opened to the green fruit stage (PubMed:30577538). Rapid and transient increase in roots from the leaf opened to the green fruit stage (PubMed:30577538)
+Expressed throughout oogenesis. In early embryos, expression drops during cellularization, remains low throughout gastrulation and increases once germband extension has begun
+Expressed in all cells of early and late embryos (at protein level) (PubMed:14623111). Expression diminishes at the time of hatching, and there is very little expression in larvae and adults (at protein level) (PubMed:14623111)
+Embryonic expression begins prior to the blastocyst stage, when maternally expressed protein is depleted. By 10.5 dpc, expression is abundant in the developing central and peripheral nervous systems. Major sites of expression include the neuroepithelium of the fore-, mid-, and hindbrain, the spinal cord, the dorsal root and the cranial ganglia. By 13.5 dpc, highly expressed in neuroblasts as well as postmitotic neurons of the cortical plate. After completion of neuronal migration expression remains high in the cortex. Also expressed in the testis from P8
+Isoform alpha is expressed from the gastrula stage, whereas isoform beta is not expressed until the tailbud stage
+Expressed in adult, pupae, third instar larvae, and 0-4 hour and 0-18 hour old embryos (PubMed:15816867, PubMed:22303848). Levels increase significantly at the late embryonic stage, gradually decrease during postembryonic development and increase slightly in the adult (PubMed:22303848)
+High rates of growth
+Earliest expression in 1.5-fold embryos, and then at later embryonic stages in neuronal and non-neuronal cells (at protein level) (PubMed:15790968). Expressed in larvae and adults in multiple neuronal and nonneuronal cells, including epidermal cells, in the head, neuronal cells in the tail and in the GABAergic DD and VD motoneurons (MNs) in the ventral nerve cord (at protein level) (PubMed:15790968). Expressed in 24 of 26 GABAergic neurons, including the 13 VD and 6 DD, and the RME L/R, AVL, RIS and DVB neurons throughout postembryonic development (PubMed:15790968)
+Expression in leaves increases with age
+In developing flowers, present at low levels in ovules
+Expressed in the precursor anchor cell and ventral uterine precursor cell (Z1.ppp, Z1.ppa, Z4.aaa, and Z4.aap) before cell specification, at early larval stage L2 (PubMed:23615264). Expressed in the ventral uterine cell (VU), but not in the anchor cell (AC), after specification, at late larval stage L2 (PubMed:23615264). Expressed in a dynamic pattern in the vulval precursor cells (VPCs) during vulval induction in larval stage L3 (PubMed:32839181). Expressed in somatic gonad cells, the distal tip cell (DTC), and all sheath and spermathecal cells, as well as in polyploid intestinal cells, in both the larval L4 and adult stages
+Expressed in mesenchymal cells of developing organs such as gut, lung, gonads and nephrogenic cord
+Expressed in the sepals and carpels of young flower buds. At stage 10 of flower development, expression in the carpels becomes restricted to the style. Also expressed in anthers and filaments. At stage 13, expressed in the region at the top of the pedicel, including the abscission zone
+Expressed in unfertilized eggs and pre-implantation embryos. Undetectable in later-stage fetuses or in adult tissues
+Diffusely expressed in the forespore throughout spore development
+During the cell cycle, levels increase during S-phase
+Expressed throughout embryonic and larval development. Expressed in hemocytes as they migrate in the early embryo and later in embryogenesis, become localized to basement membranes
+Expressed during embryonic development, expression decreases at blastocyst stage
+During embryogenesis, expressed in the embryo at the late torpedo/cotyledon stage, at the onset of maturation. Not expressed during early stages of seed development or in mature seeds
+First detected in the neurula stage and then increased and almost reached a plateau during early tailbud stage
+Detected in the anterior parencephalon and secondary prosencephalon at stages 20 and 24. Expressed in the ventricular epithelium of the spinal cord at the latest stages
+Expressed in the epiblast (the future neurectoderm) and in neuroblasts. Expressed in overlapping regions with deltaA (dla) and deltaD (dld), but differs in the neural plate: it is apparently confined to the scattered cells within those patches that differentiate as neurons, while dla and dld are expressed in patches of contiguous cells
+Maximum levels are found in 35 day old plantlets when the rosette is mature, consisting of 8-10 fully expanded leaves, and as the floral stem starts to form. This level remains constant during the further life span of the plant
+Expressed in early stages of lateral root primordium formation, becoming restricted to the endodermal cell lineage at later stages
+Expressed in developing caryopsis at 1 to 20 days after flowering. Expressed in the pericarp and endosperm at 5 and 5 to 10 days after flowering respectively
+Reaches a maximum 2 weeks after flowering and then decreases gradually
+Expressed in the pharynx and seam and vulval cells in larvae (PubMed:15489294). Expressed in the male tail tip during the L4 larval stage (PubMed:21408209)
+In seedlings, mostly expressed in small roots, and to a lower extent in hypocotyls. In young plants, equaly expressed in leaves, roots, and shoot tip. In old plants, present in roots, flower buds and young siliques, but not in leaves
+Expression starts at 11.5 dpc in the early two-layered epidermis. From 12.5 dpc, mainly expressed in the periderm cells and weakly in the epidermal basal cells. After epidermis keratinization, at 15.5 to 17.5 dpc, detected in the granular, cornified layers and in the hair follicle. Also expressed in heart, lung, bone, muscle, testis and blood vessels at 12.5, 13.5, 14.5 and 16.5 dpc, respectively
+Induced at the time of aerial mycelium formation and is most abundant during sporulation (PubMed:12111561). Induced during late aerial growth and early sporulation (PubMed:16262781). Present at early division stages, predivision stage and sporulation stage (PubMed:21205868). Mainly expressed during late development (72 h) corresponding to sporulation stage, but in the presence of whiA mutant its transcription is more than 3-fold reduced and in the presence of whiH mutant it is nearly absent (PubMed:26002075)
+Expressed at high levels in the otocyst (between 9.5 dpc and 11.5 dpc embryos fading away after 12 dpc) and in the developing eye. Lower expression is found in different sites of the embryos such as developing brain, the lungs and the cardiac outflow tract
+Late stage of sporulation
+First detected at 11 dpc and expression continues into adulthood with higher levels in embryonic than adult brain. In developing brain, not expressed in neural progenitors during the proliferative phase but expression is detected in postmitotic neural precursors shortly after exiting the cell cycle
+Present in testis of 8 day-old. Expressed in pachytene spermatocytes
+Expressed throughout development, but barely detectable in adults
+Weakly expressed in embryos as early as 21 hpf, and strongly expressed at least up to 7 dpf
+Expressed at highest level during the first stage of flower development
+In siliques, expression is first detected at stage 7 when the siliques are green-brown. Expression then rises steadily to reach a maximum at maturity
+Expressed in stigmas from flowers across developmental stages
+Expressed maternally in stage 1 embryos. Isoform 1 and isoform 4 are expressed zygotically in stage 4 in pole cells. By stage 8, expressed in 14 segmentally repeating stripes. During stage 9 and 10, expression appears in neuroblasts. After stage 14, expression is restricted to clypeolabrum, anal plate and salivary glands
+Expression peaks between 11 dpc and 15 dpc. At 7.5 dpc, expressed in germ cell layers. At 14.5 dpc, expressed at highest levels in thymus, liver, gastrointestinal tract, lung and the rapidly proliferating ventricular zone of the brain
+Expressed during cell or organ differentiation
+Transcripts are not detected at 0 and 1st day post eclosion (dpe), weakly expressed at 2nd and 3rd dpe, reach a peak on the 4th dpe, and then decline gradually until 7th dpe
+Specifically expressed in prophage stage of meiosis (PubMed:3405224)
+Expression is very low during all stages of development
+There is a marked sex difference (female >> male) in the cytosolic level of this protein. Its activity increases after birth in parallel in both sexes until the weanling stage. Thereafter the activity decreases in males, whereas it declines temporarily in females and increases again to a maximum level in adult females
+During seed development. Not expressed at 5-6 months after pollination (MAP), weakly expressed at 6-7 MAP and highly at 7-9 MAP. Weak expression level at 6-7 MAP after which expression gradually increases, with the highest expression at 11-12 MAP (at protein level)
+Expressed in the prespore cells at culminating stage
+Expression does not persist beyond the early postnatal period in the sensory region of the inner ear
+In 10.5 dpc embryo somites is expressed in a superficial patch of cells (adaxial region)
+First expressed in the developing embryo at 11.5 dpc when target innervation is complete. Expression continues into adulthood
+Expressed both maternally and zygotically. Maternally supplied mRNA is degraded during progression from nuclear stage 12 to nuclear stage 13. Zygotic expression is seen at reduced levels later in embryogenesis and during larval development. Higher expression is seen in pupae, coincident with ovarian differentiation. May be activated during the syncytial blastoderm divisions which precede cellularization, the Drosophila equivalent of the mid-blastula transition (MBT). Developmentally regulated activation of the DNA replication checkpoint may occur as the nucleo-cytoplasmic ratio increases and maternal replication factors are depleted. Elongation of the embryonic cell cycle may allow time for the transcription of genes that initiate the switch from maternal to zygotic control of embryogenesis
+Expressed at 11.5 dpc within the neuroblast layer (NBL) of the central retina. As retinogenesis progressed from central to peripheral retina from 12 dpc to 15.5 dpc, expression expanded to the entire retina with the majority of Bhlhb5+ cells being detected in the proliferating NBL. From 17.5 dpc to birth (P0), expression became restricted to the ganglion cell layer (GCL) and to the inner boundary of the NBL (INL; inner nuclear layer), presumably the newly formed ACL (amacrine cells). Predominantly expressed in post-mitotic cells in the developing retina. Expressed from 9.5 dpc in the neural tube, restricted to longitudinal ventral columns of neurons, extending from the hindbrain to the caudal spinal cord. In the developing cortex, at 12.5 dpc, expressed in the nascent cortical plate of the dorsal telencephalon (at protein level). During peak production of deep layer neurons between 12.5 and 13.5 dpc, restricted to postmigrational neurons, with no expression in the proliferative ventricular zone (VZ) or in migrating neurons. Between 15.5 and 17.5 dpc, when superficial layer neurons are generated, strongly expressed in the cortical plate and weakly in presumptive migrating neurons and in the subventricular zone (SVZ). Does not colocalize with proliferating progenitors in S or M phase in either the VZ or the SVZ; restricted to postmitotic glutamatergic projection neurons during neurogenesis. Not detected in cortical GABAergic interneurons or their extracortical sites of genesis, the medial and caudal ganglionic eminences (at protein level). Postnatally, down-regulation begins at the junction of the cingulate cortex and neocortex; by postnatal day 4 (P4), down-regulation well into the neocortex is observed anteriorly, with the exception of the most superficial layer. At P4, expressed in neocortical layers II, III, IV, and V. Within layer VI, expressed in only very rare scattered TBR1 negative neurons. Down-regulation continues from medial to lateral, exhibiting a markedly reduced expression by P14. Expression varies strikingly along the A-P axis with a precipitous decrease in the rostral cortical plate. At 12.5 dpc, highly expressed medially in the cingulate cortex with weak expression in the rest of the cortex. At 15.5 dpc, expressed in a high caudomedial to a low rostrolateral gradient. Between 15.5dpc and P0, expression increases laterally and the gradient gradually transforms into a sharp border between the presumptive rostral motor and sensory domains. During the first postnatal week, there is a further transformation from homogeneous expression across sensory cortex into discrete areas of high expression coincident with the primary sensory areas. At P4 and P7, expressed in primary visual cortex, primary auditory cortex and distinct primary somatosensory representations, including the vibrissal barrel field. In the spinal chord, transiently expressed in V1, V2, and dI6 interneurons at 10.5 dpc. Also observed in a subpopulation of late-born neurons that migrate to the superficial layers of the dorsal horn. Expression starts shortly after the neurons exit mitosis at 13.5 dpc and persisting for up to 2 weeks postnatally. At birth, about one-third of dorsal horn neurons expressing the protein are excitatory and two-thirds inhibitory. Also expressed in the developing eye and hair follicles, in the epithelial layer of the cochlea in the developing inner, and in the nasal epithelium. At 16.5 dpc, expressed outside the CNS, in particular in all sensory organs; in the nasal pits, transcripts can be detected in the olfactory epithelium. In the developing eye it can be found in the inner and outer retinal layer, and it is also detectable in the sensory layer of the cochlea in the developing inner ear. In addition, expression is found in the developing hair follicles, both in the epithelial component and in the dermal papilla, and in the skin
+Expressed most highly in 0-2 hour embryos then at lower levels in larvae and pupae
+Expressed in relatively high level in adults as compared to larval worms
+Expression weakly detectable at 6 dpc embryo, reaches a maximum at 16 dpc and declines in the adult
+Detected in all seven mating types
+Expressed in unfertilized eggs and embryos at two stages (at protein level). Expressed throughout embryogenesis
+Expression increases from day 1 to day 12 but activity decreased 10-fold during this period indicating that post translational modification is operational
+In liver, strongly expressed at 18 dpc and at birth, and then rapidly declines. In pancreas, strongly expressed at birth with decreasing expression after 4 days of age. Also shows strong expression in neonatal gut, lung and heart
+Found in fetal small intestine and thymus
+Expressed from late embryogenesis, and thereafter
+Expression increases during oligodendrocyte differentiation
+Expressed at 100-cell embryonic stage, in the pharynx, intestine, hypodermis and M lineage (M-1 to M-16 stages) at the L1 larval stage and in somatic gonad, vulva and rectal epithelium at the L4 larval stage
+Not detected before day 10.5. At day 12.5, prominently expressed in large arteries and the umbilical arteries, expressed at lower levels in the myocardium, craniofacial mesenchyme, nasal epithelium and liver capsule. At days 14.5 and 17.5, expressed in the musculoskeletal system, and ossification areas, with continued expression in the arterial tunica media
+In testis, first detected in stage VI seminiferous tubules where it is strongly expressed at the apical ectoplasmic speclialization (ES). Initially detected around the entire spermatid head, then during stage VII becomes tightly restricted to the concave side of the spermatid head. From late stage VIII through to stage XII, expressed once again around the entire spermatid head. In stage VIII-IX tubules, detected at lower levels at the basal ES associated with the blood-testis barrier. Detected at the apical spermatid-Sertoli cell junction in stage VIII-XII tubules
+Expressed in the endocardium of developing heart
+Growth phase regulated (late expression)
+Its expression was observed during transition from G0 to the S phase of tobacco mesophyll protoplasts in vitro
+Maximally expressed at 7 dpc followed by 11 dpc, 15 dpc and 17 dpc. In the limb development, its expression predominates in the limb buds at 12.5 dpc
+Ubiquitously expressed in embryos between 8.5 dpc and 10.5 dpc
+Detected in early zygote. Detected in neural keel and in Kupffer's vesicle at the eight somite stage. Detected in developing pronephric tubules, the otic vesicle and nasal placodes at 24 hpf. At 24 to 72 hpf, detected in ciliated epithelium cells of the neural tube, nasal pits and pronephric tubules. Detected in embryonic neuronal tissues, including forebrain, hindbrain, spinal cord and retina
+Expressed at low, constant levels in temporal bone from embryonic day 14 to day 1 after birth. Increases by 8 to 16-fold at day 5, 10 and 20
+During embryogenesis, expressed in early cellular blastoderm, involuting mesoderm, invaginating foregut, hindgut, in the CNS (central nervous system) and PNS (peripheral nervous system) during organogenesis, and imaginal disks (PubMed:17666430). In cyst cells, expression is restricted to post-meiotic stages during spermatid differentiation (PubMed:17666430)
+Highly expressed at day 4 post-infection of the mosquito midgut followed by a reduction at day 8 post-infection and in midgut sporozoites (PubMed:28192122). Expression is low in salivary gland sporozoites (PubMed:28192122). Not expressed during the host liver stage (PubMed:28192122)
+Ubiquitously expressed during embrygogenesis
+Expressed in 9.5 dpc embryo
+Primarily expressed in the infected cells of the fixation zones in root nodules
+Expressed in fetal liver, but absent in 4 days old and 6 weeks old unweaned pigs
+First detected at stage 14 in the early lens placode. At later stages of development, it was observed throughout the lens, but it appeared more abundant around the bow region of the equator than in the anterior epithelium or the fibers. In the retina, expression was detected mainly in the inner nuclear layer during later stages of histogenesis
+Expression reaches a maximum between 16 dpc and P0 and then declines in adulthood
+Isoforms are developmentally regulated during the formation of skeletal muscle. Isoform Alpha-7X1A and isoform Alpha-7X1C are induced upon terminal myogenic differentiation; isoform Alpha-7X1B is present earlier in replicating cells and diminishes upon differentiation
+Expressed in cardiomyocytes from 14 dpc
+First expressed in stage 8 embryos in the precardiac region and the expression continues during the development of the cardiac tube. Later expression in the atrium and ventricle. From stage 13, expressed in somites. Expression here is limited to the myotome and is not found in newly formed somites until the muscle-specific transcription factors MyoD and myogenin are present
+Expressed in embryos from day 7. Expression is low in 12 day embryos and higher in 18 and 19 day embryos
+Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually after embryoid body (EB) formation
+Widely expressed. Present in most cells from the embryo through the adulthood
+Expressed at high levels during log phase with 10-20 fold reduction at onset of stationary phase
+Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in the posterior hindbrain and has increased dramatically in rhombomere 4
+The differential expression of the fibulin family contributes to the formation of molecularly distinct extracellular matrices already during early developmental stages of a large number of tissues. Increased expression at neonate stage in the brain. Expressed in interdigital regions of the handplate of a 12 dpc embryo and in the lateral perichondrial region. Similar expression persists in the 13 dpc handplate particularly in the perichondrial regions and apical aspects of the developing digits
+Detected in distal ectodermal cells at Hamburger Hamilton stage 18 (18HH). Becomes restricted to the apical ectodermal ridge (AER) (at protein level). At stage 11HH, detected in neural ectoderm, developing optic placodes, the neural crest around the otic placodes, and along the anterior-posterior axis in somites. Detected in the ectoderm of the limb bud at 16HH to 18HH. Becomes restricted to the dermomyotome closer to the neural tube at stage 18HH. At 19HH and 23HH, detected in the apical ectodermal ridge, the developing eye and branchial arches
+Expressed in liver at embryonic stage 13 dpc, and in liver, brain and lung at 16 dpc (PubMed:11162141). In testis, expression levels steadily increase from 1 week after birth and plateau by 8 weeks after birth (PubMed:26043108)
+At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 8. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit adjacent to the somite 4/5 boundary
+In seedlings, expressed in hypocotyl and cotyledons up to the fifth day after germination. Levels decrease gradually in hypocotyl to become undetectable in 8 days old seedlings. In cotyledons, repartition becomes later patchy. In adult plants, observed in green tissues, with a gradual decrease during aging leading to patchy distribution. Also detected in seeds still partly green but disappear in dry seeds
+Expressed in larval brains (at protein level)
+Expressed in seed development and germination from day 16 after pollination to day 4 after imbibition (at protein level)
+High level during prophase and prometaphase and weaker after the chromosomes attach to the spindle and align at the metaphase plate. During anaphase, it is degraded, allowing the separation of sister centromeres (at protein level)
+Expressed in motor neurons between stages 34 and 35 (at protein level). Expressed prior to the formation of distinct motor axon pathways and before the segregation of motor neurons into columns. Expressed throughout the median motor column and the medial subdivision of the lateral motor column (LMCm)
+First detected at 11 dpc, reaches a maximum at 15 dpc, and remains constant through 17 dpc
+Expressed in embryo throughout embryogenesis. Also present in free nuclear endosperm, but disappears once endosperm cellularization begins
+Expressed at uniform levels throughout growth and development
+Exclusively expressed in postmeiotic stages of male germ cell development. First detected at day 25 p.p. when spermatids are most frequent within seminiferous tubules
+First expressed at 8.5 dpc of embryo development in a restricted mesodermal subpopulation at the anterior hindbrain level. Expression of SIX2 in the developing limb begins at 11 dpc and is more pronounced ventrally. It progresses into the developing phalanges at 12.5 dpc. At 10.5 dpc expressed in the metanephric blastema, which signals the ureteric bud to evaginate from the Wolffian duct. At 11.5 dpc expressed at high levels in the dorsal anephric mesenchyme and is down-regulated where pretubular aggregates will form on the ventral side of the ureteric bud. At 14.5 dpc, expression persists in the peripheral mesenchyme of the renal cortex. At 9.5 dpc, expressed in the splanchnic mesoderm of the stomach anlage. By 10.5 dpc, expressed in the mesoderm of the posterior stomach. Expression is seen in the presumptive glandular stomach primordium at 11.5 dpc. At 12.5 dpc, becomes restricted to the mesenchyme of the antral region of the posterior stomach. At 14.5 dpc, expression remains in the antrum, just anterior to the pyloric sphincter
+NP24 I is low in green tomatoes and it increased substantially during ripening, with the largest increase occurring between the pink and red stages. NP24 II is relatively high in green tomatoes and it increased somewhat as the fruit turned pink, but not during further ripening
+In the suprachiasmatic nucleus, it increases during subjective night with a peak at midnight under constant dark conditions. Expressed at a constant level in neurons throughout the brain (at protein level) (PubMed:10570941). Isoform 2 expression increases over development and maturation in the hippocampus. Isoform 1 expression is low in embryonic stages, increases during postnatal development and is falling back to low embryonic levels in adulthood (PubMed:20819118)
+At the vegetative stage, it is expressed in rapidly elongating and dividing organs and tissues. At the influorescence or floral stage, it is expressed in the shoot meristems and stamen primordia
+Observed in root epidermal cells and root hairs, especially in the root hair formation zone. During root hair development, both observed in root hair bulges and in young outgrowing root hairs
+Expressed in digestive system, skin, hair follicles, the dental germ, respiratory tract, various glandular tissues, kidney, liver and certain areas of the central nervous system between 8 and 16 dpc (at protein level). Expressed. in embryo between 9 to 18 dpc. Expressed at 14 dpc in the epithelial cells and 18 dpc in basal epithelial cells of intestinal crypts. Expressed in mesenchymal and epidermal structures of the body wall at 9 dpc. Expressed in basal cells of the subepidermal layer of the skin at 12 dpc. Expressed in hair follicles at 14 dpc
+Detected at 13 hours post-fertilization (hpf) in the precursor cells of adaxial cells (slow twitch muscle fibers) of the paraxial mesoderm (PubMed:29888752). At 22 hpf, detected in the developing heart (PubMed:29888752)
+During anther development highly expressed in tapetal cells at stages 6 and 7, and at lower levels in the pollen mother cells and meiocytes
+Expression commences in corneal peridermal epithelium in the embryo at 15.5 dpc (PubMed:16431949). Between 15.5 dpc and postnatal day 4 (P4), expression is restricted to the suprabasal and/or superficial cells when the corneal epithelium begins to stratify (PubMed:7508359, PubMed:16431949). At P30 expression is sporadically detected in the basal corneal epithelium and the number of positive basal cells increases as the mice grow older (PubMed:16431949)
+Expressed predominantly in gut precursor cells from the 4E embryonic stage until the bean stage. Expression resumes at the L1 larval stage and continues into adulthood
+First appears in neural crest cells of the mandibular stream at stage 15. By TS4 (Townsend and Stewart) is active in the migrating neural crest cells of all streams: the mandibular, hyoid, and first and second branchial. Continuously expressed in the branchial arches through TS5 and TS6 and begins to be expressed at the edges of the limb buds at TS6. Detected in cells of the forebrain at stage TS5
+Specifically expressed in proliferating tissues during embryonic and larval development
+Expression starts 2 hours post-sporulation
+Expressed at all stages examined including 17 dpc, 19 dpc, P2, P10 and P14. Expressed in neocortex, hippocampus and neuroepithelium at 17 dpc and more prominently expressed in striatum, hippocampus and cortex at postnatal days (at protein level)
+Detected at all stages. Found to be more abundant in larval stages than in embryos or adults
+Expressed during late S phase and G2 phases
+Expressed during early embryogenesis and in adult females (at protein level)
+Localized predominantly in the cytotrophoblast layer of trophoblast cells during the first trimester of pregnancy, and to the syncytiotrophoblast and stroma cells during the third trimester
+Fetal
+In 10-day embryos B94 is expressed prominently in the myocardium and in the aortic arch. By the 15th day of gestation, expression is restricted largely to the liver, the bone forming regions of the jaw, the aortic endothelium, and the nasopharynx: a pattern that is maintained until just prior to birth. Postnatally, expression shifts to the red pulp of the spleen and the thymic medulla
+Down-regulated during development of THP-1 monocytes into macrophages
+Expressed throughout silique development (PubMed:16622707). During anther development, expressed from stage 9 to stage 11 in late tapetum, and mature pollen grains (PubMed:21673079)
+Expressed in embryos at the cotyledon stage
+Mostly expressed in young tissues. Expressed in all parts of floral buds, but later confined to stigma and anthers
+In the neonatal stage, and during embryogenesis on days 16, 17 and 19, an expression pattern similar to the adult was observed. In addition at stage 16, expression was detected in small intestine
+First expressed in the anterior neuroectoderm at 7.5 dpc. At 8.5 dpc, the expression is present in future forebrain and midbrain regions. At 9.5 dpc, the expression is intense in the forebrain and midbrain with a sharp caudal boundary at the isthmic region; a low level of the expression is found throughout the neuroectoderm. Not expressed in the ventral body wall
+Cell-specific pattern of expression. Broadly expressed during embryonic development
+Highly expressed in growing cells. Expression levels decrease during the first few hours of development
+First detected at 10.5 dpc in the gonadal component of the urogenital ridge. Expression dramatically increases by 11.5 dpc in the urogenital ridges and in the cranial surface ectoderm. At this time, it is also expressed in the trigeminal ganglion and nodose ganglion. At later stages, it is expressed in the brain and organs derived from the urogenital ridge, including the gonadal tubercle, kidneys, and adrenal glands. From 14.5 dpc to birth, expression is evident in the developing retinal neuroepithelium and the vibrissa
+Only present in a-cells and in a/A diploid cells
+Expressed both maternally and zygotically at relatively consistent levels throughout development
+Expressed in fetal heart, lung, liver and to a lower extent in brain. Not expressed in adult brain
+At 16.5 dpc, detected in fibrillar structures in various elastic tissues, including developing dermis, perichondria surrounding cartilages and the vessel walls of aortae (at protein level). At postnatal day 7 (P7), weakly expressed in the early stage dental follicle, but becomes readily detectable in assembled microfibril-like structures during the periodontal ligament-forming stage of the dental follicle and in organized microfibrils in the adult periodontal ligament (P35) (at protein level). Up-regulated in the periodontal ligament during wound healing (at protein level)
+Expressed as early as 6 weeks of gestation (Carnegie stage 16). Ubiquitously expressed during fetal development and postnatally in all adult tissues tested
+Expressed both maternally and zygotically. Expressed from stage 1 of oogenesis. Expressed at a low level in the embryo from the tenth nuclear division to the end of cellularization in all cell nuclei except those of pole cells. Also weakly expressed in the embryo after germ-band retraction, and in larvae (at protein level)
+Accumulates throughout the neural plate at the anterior head folds of the 9 day embryo but only at its lateral tips in more posterior regions. Following neural tube closure, expression is restricted to specific regions of the dorsal wall of the brain ventricles and spinal cord, the ventral wall of the midbrain and the diencephalon, and the lateral walls of the neuroepithelium at the midbrain-hindbrain junction
+Widely expressed in fetal tissues including fetal brain
+Expression detected in fetal ovaries between wpf (weeks post-fertilization) 11 and 27; expression peaks at wpf 14.5 and is decreasing afterwards
+Expressed from late embryogenesis to adulthood
+Expressed from the L1 stage of larval development to adults
+Present in fetal hypothalamus at 19 weeks of gestation (at protein level)
+Highly expressed during late spermiogenesis, in condensing spermatids (at protein level). Expression persists in mature spermatozoa (at protein level). Expression is first detected from the round spermatid stage and increases thereafter
+In flowers, expressed in anthers, pollen and developing ovules (PubMed:17293437). In inflorescences, accumulates mainly in mature pistils (PubMed:27524487). In developing ovules, observed at the micropylar region in a polarized localization of the synergid cells and in inner integument surrounding the female gametophytes (at protein level) (PubMed:27524487). In mature ovules, present in the filiform apparatus and in the integuments at the micropylar region (PubMed:27524487). At later developmental stages, localization shifts from the micropyle toward the chalazal end (PubMed:27524487). Also present in the funiculus and at the junctions between the transmitting tissue and the funiculus (PubMed:27524487). Levels fade out in ovules after pollination and subsequent fertilization (PubMed:27524487)
+Expressed predominately at the early stages during embryogenesis
+First appears at low levels in 3 week old mice. Levels increase rapidly after 4 weeks, highest levels are reached in 8 week old mice
+In root tips, preferentially expressed in quiescent center (QC) cells, cortex/endodermis stem cells and their daughter cells, and endodermal and stele cells of root meristems
+Meiosis-specific. mRNA is spliced only during meiosis
+Present during infection; expression is higher in hausturia than epiphytic mycelia
+At 9.5 dpc, expressed in the forebrain, through the optic stalk and ending in the proximal portion of the optic vesicle. At 10.5 dpc, expressed in the optic stalk, outer layer of the optic cup, and the primordium of the pigment epithelium. In the pigment epithelium, down-regulated after 11.5 dpc, and expression restricted to the optic stalk and the ventral forebrain
+Expressed during vegetative growth. Expression decreases rapidly during early development and is not detected after 12 hours of development
+Expressed in the intestine from embryogenesis to adulthood. Highly expressed in the most anterior and posterior parts of the intestine in hatched larva. Also expressed in cells outside of the intestine near the anus in hatched larva
+In the presomitic mesoderm (PSM), expression is first detected at stage 7 where the first somite pair originates from both sides of the neural tube (PubMed:26299926). At stage 15, expression is detected in the anterior PSM (PubMed:26299926). During stage 18, also expressed in the newly forming somites and the PSM that reaches beyond the leg bud (PubMed:26299926). At stage 23, expressed in the somites and PSM near the tip of the tail and also in the wing and leg buds (PubMed:26299926)
+Expressed throughout the emerging primitive streak at stage 2 (PubMed:16943268). At stage 3, expressed in both the anterior and posterior parts of the primitive streak (PubMed:16943268). At stage 4, expressed in Hensen's node and the anterior part of the primitive streak (PubMed:16943268). At all stages, expressed at lower levels than isoform 2 (PubMed:16943268)
+Expressed throughout the emerging primitive streak at stage 2 (PubMed:16943268). At stage 3, expressed in both the anterior and posterior parts of the primitive streak (PubMed:16943268). At stage 4, expressed in Hensen's node and throughout the anterior, middle and posterior part of the primitive streak with a peak of expression in the middle part (PubMed:16943268). At all stages, expressed at higher levels than isoform 1 (PubMed:16943268)
+In germinating seed, present in the embryo epidermis, in cotyledons and in leaf primordia of the first true leaves. In cotyledons, mostly expressed in guard cells and vasculature. Observed in developing leaf buds, including the nodes and buds of cauline leaves (PubMed:26990896). In flowers, expressed in all organs, levels decreasing during flower aging. In the pistil, accumulates mostly in the abaxial epidermal cells, and, to a lower extent, in the septum and the inner ovary wall (PubMed:16415209, PubMed:26990896). Also expressed in the stigmatic papillae and vasculature of the sepals, petals and stamens. Accumulates in embryo during seed dehydration. Present in the central cylinder of the roots. In addition, detected in suberized tissues, such as siliques abscission zone and seed chalaza/micropyle region (PubMed:26990896)
+Highly expressed in endothelial cells during embryonic development from 9.0 dpc
+Expressed from G(0)/G(1) through mid-G(1) in normal cells, and at a constant level in rapidly growing cells
+First detected at embryonic day 15. At postnatal day 14 detected in skin, spleen, liver, kidney, heart, testicle, lung and brain. At adulthood is most abundant in brain
+Ubiquitously expressed during development
+Low level expression is detected in embryonic development with no distinct tissue specific enrichment. Expression levels increase at third larval instar stage and continue through to adulthood
+Expressed zygotically. First detected at mid-gastrula stage
+Not expressed maternally. Expression begins shortly after the midblastula transition, peaks at the early gastrula stage and is still detectable until the tailbud stage. Accumulation during the blastula stage precedes that of the organizer genes gsc, lhx1/lim-1, and t/bra
+Expressed throughout development, highest expression seen in second instar larvae, pupae and adults
+Increased expression when preadipocytes are induced to differentiate to adipocytes. Not detected in proliferating or confluent preadipocytes
+Expressed at 15 dpc in hippocampal, cortical and cerebellar brain, and brain stem and spinal cord. At 18 dpc, expression strongly overlaps with TUBB3 expression in post-mitotic neurons throughout the entire brain. Expression levels increase to 18 dpc/P1 after which the levels decline in the hippocampus, cerebellum and brain stem and spinal cord into adulthood while remaining high in the cortex
+Expression starts at the embryonic bean stage and continues throughout larval and adult stages in few anterior body wall muscle cells and in unidentified cells in the head (PubMed:19427847). Expressed predominantly in pharyngeal cells during embryogenesis and throughout larval and adult stages (PubMed:20713707). In L1 larvae, expressed in all pharyngeal neurons (M4, I1, MI, I3, M3, NSM, MC, I2, I4, I5, I6, M1, M2, and M5), some pharyngeal muscle cells (pm1 and pm2) and pharyngeal epithelial cells (e1 and e3), and some body wall muscles around the anterior pharynx (PubMed:20713707). Expressed transiently in the M lineage-derived coelomocyte precursor cells M.dlpa and M.drpa before their differentiation into coelomocytes (PubMed:19427847, PubMed:20335356). Expressed in the M4 motor neuron sister cell (PubMed:20713707)
+Expressed both maternally and zygotically. Most abundant during early oogenesis during stages I and II, and expression levels drop by oocyte maturation. Expressed at the 1-cell stage and then again after the MBT from the blastula to early gastrula (shield) stages, during which expression levels decrease. Not detected after gastrulation until adults
+Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863)
+Expressed both maternally and zygotically. Zygotic expression is high in middle-stage embryos, lower in middle-stage larvae, dropping through pupal development to be much lower in adults
+Abundantly expressed during pupation and decreases rapidly with age. Expression is under pupal (eclosion) circadian clock control
+Detected in blastomere, near the blastoderm margin in gastrula, and in forebrain, posterior hindbrain and throughout the length of the trunk at early segmentation stages
+Expressed throughout the blastoderm early in development. Highly expressed in the developing brain at 24 hours post-fertilization (hpf), and at lower levels in the rest of the embryo
+Expressed at very low levels at birth and undergoes a marked up-regulation between postnatal days 10 and 20 (PubMed:10402197). Up-regulated in the visual cortex between postnatal day 28 (P28) and P60, when experience-dependent brain plasticity declines (PubMed:21071629)
+Expressed predominantly during embryogenesis
+Expressed during development. Expression levels increase steadily during aggregation and peak at 10 hours until after which they decrease steadily until late culmination
+Expressed in dorsal pallium and in and around the developing choroid plexus at 10.5 and 12.5 dpc
+Levels decrease significantly with age
+Expressed at low levels in hyp8-11 tail tip cells during the early L4 larval stage (PubMed:21408209). Occassionally, expression is high in hyp10 tail top cells during this time (PubMed:21408209)
+First expressed at the 1-somite stage in the presumptive rhombomeres 3 (r3) and 5 of the developing hindbrain. By the 3- to 4-somite stages, r5 expression has increased and there is weak expression in r4 and posterior to r6. From the 10- to 20-somite stages, confined to r3, r4 and r5 with highest levels in r3 and lowest levels in r5
+While it is expressed ubiquitously throughout the mouse embryo, at 9.5 dpc its expression begins to be localized to the brain, neural ganglia, neural tube, and in liver at 12.5 dpc. At 15.5 dpc, the expression is further restricted to specific tissues of the embryo
+High levels seen in the epidermis on day 0, but rapidly disappears and is undetected on days 1-4 of fifth instar. It reappears on day 5 and peaks on day 7 after which a rapid decline is seen. In the gut is detected on day 6 with lower levels seen on days 0, 7 and 8
+Highly expressed at 5 and 15 hpf. Expression is higher in brain and eye. The expression drops after 72 hpf
+Detected in embryonic testis at 14.5 dpc and decreases by postnatal day 5
+Expressed in embryos, larvae and adults (at protein level). Expression transiently increases prior to the larval L2/L3, L3/L4 and L4/adult molts
+Very weakly detected in planulae, but moderately and equally detected in primary polyps (9d), and in both adult females and males (at protein level) (PubMed:33060291). Transcripts are expressed early in the life cycle and their expression is maintained through the adult stage (PubMed:29739837)
+First expressed at a low level at stage 18 (late neurula), with high levels of expression seen from stage 32 through to stage 48 (tadpole)
+Expressed during the asexual blood stage, including in rings, trophozoites and schizonts (at protein level) (PubMed:32591529). Expressed in gametocytes (at protein level) (PubMed:32591529)
+Expressed in the germline and soma throughout development (at the protein level) (PubMed:22548001, PubMed:22829772). Highly expressed in embryos (PubMed:22548001, PubMed:22829772). Expression is lowest during the early larval stages and increases as the germline proliferates, peaking at the adult stage (PubMed:22548001)
+Observed at low levels in stamen filaments and at the very edges of mature leaves
+Expressed throughout seed development in the pericarp and endosperm tissues with a peak at 8 days after pollination in the outermost cell layers located centripetally to the endosperm
+Up-regulated during G0/G1 phases
+Expressed in AB cell descendants in embryos
+Detected at low levels in very young and young stages, before increasing to high levels during the nearly mature and mature stages
+Expressed during all parasite blood stages (at protein level)
+Expressed 30 minutes after infection and remained present through to 21 days. Expressed in white or callow pupae during metamorphosis, but no expression was seen in larvae
+In mid instar larvae salivary glands, levels increase during puff stage 1, then remain relatively constant until the premetamorphic pulse of ecdysone at puff stage 5. Levels increase again in late larvae at puff stages 9-10. At puff stage 1 expression is also seen in the gut. Levels are low in the gut, Malpighian tubules, fat body and wing disks between stages 1 and 11
+Expression seen in many tissues of ectodermal and mesodermal origin during embryogenesis. First detected at bud stage in the ventral prosencephalon and along the length of the notochord. As segmentation proceeds, expressed in the optic primordia, otic placodes and diffusely in cells over the yolk lying ventrally to the tail bud. Midway through the segmentation period, expression also seen in the acostic and lateral line sensory ganglia. At 22 hpf, found in the most posterior portion of the pronephric ducts (PubMed:10664151). At the end of gastrulation, expression seen in the prospective ventral forebrain, single eye field and the presumptive notochord. At 12 hpf, expression in the midline found only at the posterior end of the notochord where it can be detected until the end of segmentation. At 20 hpf, expression in the eye is restricted to the dorsal retina and also found in the epiphysis, otic vesicles and sensory neurons of cranial ganglia. At 22 hpf, expressed in bud of pectoral fins and at 30 hpf, in a subset of interneurons in the anterior spinal cord (PubMed:10331981)
+Present from early embryonic stages through adulthood
+Expressed in plastochron 0 (P0) leaf founder cells, and leaf plastochrons P1, P2 and P3 primordia, but not beyond. Expressed in developing bract leaves and their incipient primordia of young inflorescence apices. Down-regulated in developing spikelets
+At 17 dpc expressed in cells of the ventricular wall in the lateral and third ventricle and to cells in the neuronal parenchyma. At PN1, mainly expressed in the walls of the lateral and third ventricles with an apical polarization
+During fruit development, expression is detected at mature green and breaker stages, and then drop dramatically beneath detection limit at ripe and red-ripe stages
+Highly expressed in embryonic brain at day 12. Expressed at intermediate levels during the rest of embryonic development and in newborns up to day 3. After this expression decreases and stabilizes at low levels of expression around day 13
+Expressed in the embryos of all stages examined and in some adult tissues including eye, kidney, ovary, urinary bladder and testes; however, the overall expression levels in adult tissues are relatively low compared with those in embryonic tissues
+Isoforms are developmentally regulated during the formation of skeletal muscle. Undifferentiated (replicating) myoblasts express isoforms containing segment B only, whereas differentiated myoblasts express isoforms containing segments A or B
+Very lowly expressed in mycelia, expression is higher in the primordium and fruiting body (PubMed:23801251). In the fruiting body, expression is highest in the stipe, followed by the pileus and gills (PubMed:23801251)
+Mainly present in dividing tissues and fades out during cells differentiation, to reappear later in the vasculature (PubMed:29139551). Expressed in developing embryos and procambial, cambial, and vascular cells of cotyledons, leaves, roots, hypocotyls, and anthers (PubMed:25149602). During leaves development, first observed in leaf primordia, and becomes localized to the margins and the base of the lamina during the transition from cell proliferation to expansion and differentiation (PubMed:29139551). Later confined to petiole primordia (PubMed:29139551). Also detected in flower primordia (PubMed:29139551)
+Expressed in the embryo and larva (at protein level)
+Present in nucleus throughout development
+Detected in the yolk sac endoderm at embryonic stage 9.5 dpc
+Increases steadly with the age of embryo, reaching highest levels in embryonic tissues of 19 days of gestation
+Expressed in the dorsal root ganglia and the sciatic nerve at 13.5 dpc (at protein level)
+Expressed throughout embryonic, larval, pupal and adult stages, with increasing levels during larval development. Transcripts first detected during embryonic stages 12-13
+In airway epithelial cells, highly expressed during cell proliferation with levels decreasing as cell differentiation progresses (at protein level)
+First expressed at the end of embryo gastrulation in a pair of ventral neuroblasts, the left/right symmetric pair of SMDD/AIY mother cells, ABpl/rpapaaa, also known as NB(SMDD/AIY) (PubMed:19386265). Transiently expressed in SMDD motor neurons immediately after cleavage of the SMDD/AIY mother cells and then expression disappears during embryonic elongation (PubMed:19386265). Expressed during embryogenesis and persists through to adulthood in AIY interneurons (PubMed:11493519, PubMed:19386265). Expressed at L1 stage and through adulthood in AIA and NSM neurons (PubMed:24353061, PubMed:11493519). Expression is detected in head muscles of all 1.5 and 2-fold embryos, 47% of embryos just before hatching and 6% of early larvae with no expression in head muscles of late stage larvae or adults (PubMed:9292724)
+Expressed in the mesoderm, including the intermediate mesoderm, the origin of the pronephros, at 90% epiboly (8.5 hpf) and early somitogenesis stages (11.5 hpf)
+At 13.5 dpc and 16.5 dpc, expression in the brain correlates with the proliferate ventricular zone and post-mitotic neurons of the intermediate zone, particularly in the forebrain. More marked expression at 16.5 dpc in the telencephalic septum and in the pallium. In myocytes, expressed throughout differentiation of myotubes
+Fluctuates in a circadian fashion, with highest level in night and lowest in the morning (at protein level)
+In testis, expression almost doubled from day 5 to days 17-22 postpartum (dpp) and then decreased by 28 dpp to reach a stable level in adult testis
+Strongly expressed in the stigma and pollen grains. Present at lower levels in sepals, filaments, and anther wall. Absent from the ovary
+Appears first at nuclear cell cycle 11 and disappears rapidly as cellularization begins. During cycle 14, nullo protein levels are coupled to the nucleocytoplasmic ratio
+Early development of fruit and ripening
+First expressed around the 50-cell stage of embryogenesis in proliferating cells that are primarily located at the anterior of the embryo in the early M lineage (at protein level) (PubMed:16107479, PubMed:18316179, PubMed:22537498). During morphogenesis, expression becomes restricted to a small subset of head neuronal precursors, including AIM and ASK (at protein level) (PubMed:16107479, PubMed:18316179). Expressed in precursor cells of the left and right ventral CEPsh glia, ABplpaaapap and ABprpaaapap, respectively and also in precursors of dorsal CEPsh glia (PubMed:18508862). Expressed in the duct and pore lineages, persisting through the stages of ventral enclosure and 1.5-folds of embryonic development, but not detectable by the L1 larval stage, when duct and pore cells achieve mature morphology (PubMed:22537498, PubMed:25738873). Expressed in ABpxp descendants that give rise to the excretory system (PubMed:25738873). Transiently expressed in AWC neurons in L1 larvae until abolished shortly after hatching (PubMed:20150279). During the L2 and L3 larval stages, expressed in a group of proliferating cells surrounding the gonad (PubMed:18316179)
+Localizes to centrosomes both in sperm and in the syncytial part of the gonad. Staining in the gonad disappears as the meiotic nuclei cellularizes to form oocytes, presumably marking the point at which the centrioles are lost during oogenesis. In newly fertilized embryos, it is localized to a discrete spot near the sperm-derived pronucleus. Then, it remains attached to the centrosome throughout the rest of development
+Expressed in all adult and larval stages. Expression is cyclical and coincides with each of the larval molts, peaking at 12, 18, 24, and 30 hours post-hatching
+Localizes to the merozoite surface. Mostly concentrated in secretory organelles at the apical end of the parasite, exclusively at an early stage of schizont development. Probably localizes in the rhoptry organelles
+Higher expression in neonatal kidney than in adult. In the neonatal kidney, expressed more strongly in primitive nephrons undergoing early morphogenesis than in more developed structures. In 1-day old rat kidney, restricted to the first recognizable primitive nephron structures. Up-regulated after partial hepatectomy, with a peak after 24 hours
+Highly expressed in the embryo
+Expressed in the ovary, where it localizes to nuage and to the Balbiani body (PubMed:30086300). Maternally provided and localized to the germ plasm in 4-cell stage embryos (PubMed:30086300). 24 hours post-fertilization, restricted to primordial germ cells, where it localizes to nuage (a peri-nuclear protein-RNA aggregate that associates closely with mitochondria) (PubMed:30086300)
+Detected early in spermatogenesis. Detected in condensing spermatids (at protein level) and is up-regulated during late spermatogenesis
+Expressed in inner enamel epithelium (IEE) cells of molars at 14 dpc and 17 dpc, during ameloblast development (at protein level) (PubMed:30426815, PubMed:34812512). Expressed in molars and incisors at postnatal day 1 (P1) (at protein level) (PubMed:30426815). Expressed in Hertwig epithelial root sheath (HERS) cells during molar development (at protein level) (PubMed:30426815). Earliest expression in the incisor region at 11 dpc (PubMed:30426815)
+Ras2 level drops significantly just after the head is cut. The expression goes up again after 4 to 8 hours
+Expressed in heart, muscle, brain, liver, thigh, stomach and lung at 14 dpc (at protein level). Expressed in embryo at 7, 11 and 17 dpc. Expressed in the developing central nervous system from 12 to 16 dpc
+Expressed in early embryonic cells, more specifically in embryonic regions undergoing dramatic rearrangement, such as the developing neuroepithelium which proceeds with neural tube closure, the anterior splitting lateral plate mesoderm that wraps the pericardial cavity and the differentiating somite epithelium (PubMed:22072575). Widely expressed throughout the epiblast and the lateral plate mesoderm at 7 dpc. At 7.5 dpc-7.75 dpc, continues to be expressed in these regions, and expression is also found on the apical side of the embryonic endoderm, and extraembryonic amnion and allantois (PubMed:22072575). At 8-8.5 dpc, expression is also detected in the heart tube, foregut and the apical side of the somite epithelium (PubMed:22072575). Stronger expression is detected on the apical sides of the splitting lateral plate mesoderm, and the apical side of the neural ectoderm at trunk region (PubMed:22072575). Not expressed in the notochord plate or the extra-embryonic endoderm (PubMed:22072575). Expressed in the developing spinal cord, eye, and forebrain at 10.5 dpc (PubMed:17920587). Expressed in the ventricular layers of the developing neural tube along the entire cranial-caudal length, including the anterior forebrain and the posterior spinal cord at 11.5 dpc (PubMed:17920587). Expressed in apical epithelial kidney cells at 15.5 dpc (PubMed:17920587)
+Expressed in sporulated oocysts
+Expressed both maternally and zygotically. Present throughout the preblastoderm and remains at a high level during syncytial divisions. From cellularization, expression decreases and at cellular blastoderm maternal expression has nearly completely disappeared
+During lateral root formation, already visible in stage I lateral root primordia, and accumulates at strong levels during later stages of root development
+Expression starts in the embryo and continues through young adulthood with lower levels in older adults
+First detected in the embryo at the blastocyst stage. Little or no expression detected in adult tissues
+Highly expressed in differentiating neurons. From 16.5 dpc, expression is widespread in brain, spinal cord, and peripheral nervous tissue. Within the developing CNS, expression is restricted to regions of brain and spinal cord containing differentiating neurons
+Expressed in embryo at 14 and 17 dpc
+Accumulates during pod development
+Expressed in peri-urothelial cells of the proximal ureter and renal pelvis at 9 weeks of gestation
+Expressed in embryos, and adult males and females
+During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells. ENO2 levels in brain increase 10-30 days after birth. Levels continue to accumulate over the following few months (protein only)
+Expressed from stage 12
+Expressed at high levels in young leave and fades out during aging
+Expressed in both mitotic and postmitotic Sertoli cells
+In the developing axillary shoot apical meristem (SAM), expressed at the boundary between nascent axillary meristems and the adaxial side of leaves. In all mature SAMs, located at the boundaries between the central SAM and the initiating organ primordia, as well as between the neighboring initiating organ primordia. In the floral meristem, strongly expressed at the boundaries between the meristematic dome and the initiating floral organ primordia, and also at the boundaries between the primordia of different whorls. Expression at the boundaries attenuates as the organ primordia grow apart. In flowers, localized at the boundary between the central meristematic cells and differentiating stamen primordia to later accumulates at the medial ridge region of the carpel. Highly expressed in the developing anthers, in both the tapetum cell layer and microsporocytes. In developing ovules, confined to inner and outer integuments. In aerial tissues, strongly present in phloem tissues (PubMed:15367721). First observed in the whole embryo, but later confined to the center cells of the embryo and provascular tissues (PubMed:15367721, PubMed:20643354)
+Expressed and active during embryonic development
+Found in 13-day-old embryo heart
+Detected in lung at embryonic stage 18.5 dpc. During gestation, expressed in the mammary gland from 6.5 dpc with highest expression at 10.5 dpc. Expression then declines, but later increases again during mammary gland involution at 4-21 days post partum
+Expressed during the asexual blood stage in late rings, trophozoites and schizonts (at protein level) (PubMed:9879894, PubMed:12166515, PubMed:17895246, PubMed:20591164, PubMed:33536500, PubMed:19196988). No expression at the early ring stage (at protein level) (PubMed:12166515, PubMed:20591164)
+Expressed at low levels during the asexual blood stage in trophozoites and early schizonts (at protein level) (PubMed:9879894, PubMed:20591164). No expression at the early ring stage and in mature segmented schizonts (at protein level) (PubMed:20591164)
+Expressed during the asexual blood stage in mature rings, trophozoites and schizonts (at protein level) (PubMed:9879894, PubMed:12166515, PubMed:20591164, PubMed:21659511). No expression at the early ring stage (at protein level) (PubMed:12166515, PubMed:20591164)
+During lateral root formation, expressed in the lateral root primordia, and the developing, emerged, and mature lateral roots
+Expression is first detected at embryonic day 15.5
+Expressed in embryonic stem cells. During embryo development it is expressed in neuroepithelium of primary brain, limb bud, vessels, thymus, and around the palate
+At 8.5 dpc, highly expressed in the first branchial arch, somites, splanchnic mesoderm and ventral foregut epithelium. At 9.5 dpc, highly expressed in motor neurons and superficial neurons from the neural tube, and in the dorsal part of diencephalon and mesencephalon. At 11.5 dpc and 12.5 dpc, expressed in limbs. At 15.5 dpc, highly expressed in brain and spinal cord
+Shows increased synthesis after entry into stationary phase
+Expressed throughout embryogenesis from syncytial blastoderm stage
+Barely detectable in 3-days-old seedling, and then increases
+Expressed during microsporogenesis when microspores are released from tetrads
+Peaks in early mitosis before septation
+Enriched at G2/M
+Predominant in amastigotes
+Detected from 3.5 dpc in the inner cell mass of the blastocyst (PubMed:22144916). Expressed throughout the extra-embryonic ectoderm, which gives rise to the nervous system and epidermis, after implantation and gastrulation (PubMed:22144916). Starting from 9.5 dpc, expression becomes more restricted and at 13.5 and 14.5 dpc it is enriched in developing whiskers and eyes (PubMed:22144916). From 15.5 dpc, when the interfollicular epidermis begins to stratify and follicular morphogenesis starts by forming hair placodes, highest expression is observed in the suprabasal layer of interfollicular epidermis (PubMed:22144916)
+In embryos at 16.5 dpf, detected in lumbar and thoracic vertebra, the basisphenoid bone, the mandible, the coronal suture between the frontal and parietal bones, the maxilla, the nasal bone and the palate, as well as in the bone collars of long bones and digital bones in hind limbs, and in the primary ossification center
+In the spinal cord it is found in neurons that are migrating or have reached their final position. Expressed in cells located at the outer portion of the developing retinal neuroepithelium, the location where prospective photoreceptors reside
+Present in both bundle sheat and mesophyll cells of etiolated seedlings, protein levels increase in bundle sheath cells but not in mesophyll cells upon illumination
+Maternally expressed transcript was ubiquitously distributed in fertilized eggs and in early embryos. Zygotic expression became evident by the neurula stage and transcripts were detected in epidermal cells of the posterior half of embryos
+Present in the fertilized egg and in cleavage and blastula stage embryos. During gastrulation, expression increases significantly and is detected in mesoderm, marginal zone ectoderm, and cells of the blastocoel roof. Later in development, prominently expressed at intersomitic junctions, in the brain and in several cranial nerves
+At the first step of spermiogenesis concentrated around the acrosome. Afterwards expressed between the edge of the acrosome and the perinuclear mantle of the manchette. Next, encircles the upper site of the acrosome and forms the rim of the sperm nucleus. With the formation of mitochondria and mature spermatozoa, localized at the neck and annulus regions
+Highly expressed in the vegetative cells and decreases during subsequent developmental stages (6-24 hours)
+Expressed in retina at stage 42. In swimming tadpole, expression begins from stage 40, is clearly visible at stage 43 and increased markedly by stage 45/46. Expression appears to be restricted to the head
+During anther development, expressed in tapetal cells, parietal anther wall layers and microsporocytes from late stages 8 to stage 10
+Transiently expressed in the central nervous system (CNS) during development. Predominantly expressed in the tailbud of embryos. Also detected in the primitive streak, dorsal neural tube, forebrain and migrating neural crests of embryos. Detected from day 9.5, in various neural and mesodermal derivatives, mainly along dorsal neural tube and diencephalon. Strongly expressed in limb buds, particularly in the morphogenetically active region such as the apical ectodermal ridge (AER). The developing skin showed expression in patches of the developing dermis at 12.5 dpc and at lower levels at 14.5 dpc. By 18.5 dpc expression is restricted to the dermal papilla of the developing hair, which persisted into adulthood. In the developing kidney, strong expression at 11.5 dpc in the uninduced metanephric mesenchyme is observed. By 14.5 dpc this expression is restricted to the condensing mesenchyme surrounding the ureter and the developing nephrons. Specific expression in the urogenital ridge as early as 10.5 dpc in the coelomic epithelium. Sex-specific differences of expression began to appear starting at 12.5 dpc, with an increase in the somatic cells of the XX gonad
+Expressed in vegetative cells but is rapidly turned over during early development before reaccumulating during late development in prespore cells but not in prestalk cells. Expression decreases in early development and reappears in late development. Highly expressed in prespore cells at the slug stage (at protein level)
+Expressed in developing seeds, with a maximum at 16 days after pollination. Not expressed in nodules
+Predominantly expressed in developing vascular tissue of the leaves and roots, and in developing flowers
+At 16 dpc and 18 dpc, widely expressed with higher expression levels in neural tissues. In the spinal cord, expressed as early as 12 dpc until P21, the expression levels decrease in the adulthood (at protein level)
+Expressed throughout development. Transiently activated by ATR-mediated phosphorylation from the midblastula transition (MBT) to the initial gastrula stage. Developmentally regulated activation of the DNA replication checkpoint may occur as the nucleo-cytoplasmic ratio increases and maternal replication factors are depleted. Elongation of the embryonic cell cycle may allow time for the transcription of genes that initiate the switch from maternal to zygotic control of embryogenesis
+Expressed at very low levels during embryonic development and at moderate levels in the larva, prepupal, pupal and adult stages
+Expressed, at low levels, throughout flower development (PubMed:20215586). In corollas, accumulates progressively during flower development, from buds to anthesis (PubMed:20215586)
+Developmentally regulated with a peak during culmination. Slightly enriched in pstO and rearguard cells
+Detected 5 days after birth, increased to a maximal level at 15 days, and then decreased gradually to 10% of its maximum level in adult
+Expressed during vegetative growth, but not in developing cells
+Highest expression is found in fifth instar larvae, decreasing through prepupae, early-phase pupae (1 day after pupation) and late-phase pupae (at protein level). Much lower levels present in adult
+In leaves, first observed at low levels in a diffuse pattern 3.5 days after germination (DAG), spreads throughout much of the lamina by 4 DAG and becomes increasingly restricted to presumptive veins from 5 to 8 DAG. Confined in epidermal cells of the proximal margins in mature leaves
+Produced in the predivisional sporangium, but does not become active in directing gene expression until after septum formation when its activity is restricted to the forespore (at protein level)
+Expressed at very low levels at 7 dpc, is most strongly expressed between 11 and 15 dpc, and persists at moderate levels at 17 dpc (PubMed:8595881). Also expressed in the adult (PubMed:8595881)
+Expressed throughout embryogenesis with maximum expression at 10.5 and 12.5 dpc
+Expressed zygotically. Weak expression at 75% epiboly. At the 2-somite stage, expressed in the presumptive rhombomere 4 (r4) region partially overlapping with the r3 region. At the 10-somite stage, expressed in the r4, r3 and r2 regions. At the 14-somite stage, expression extends to the r5 and r6 regions and is observed in the diencephalon. At 24-48 hours post-fertilization (hpf), additionally expressed in the eye, midbrain-hindbrain boundary, cerebellum, pectoral fin and the pharyngeal arch primordia
+Expressed zygotically from stages 12 to 14 (late gastrula to early neurula), increasing in concentration up to stages 40 to 45 (late tadpole). Expression continues through to adults
+Expressed at high levels in the fetal liver, lung and kidney
+In 5-day-old seedling, expressed in the maturation zone of roots, and later in the whole root tip. In 9- to 13-day-old plants, expressed mainly in the elongation zone of roots. In 14-day-old plants, expressed in the whole root tip, the apex and base of lateral roots, the lateral root primordia and crown roots
+Expressed during mid/late-gastrulation at the rostro-medial regions of the anterior neural plate. Expression becomes more pronounced as neurulation progresses and remains localized within the prospective telencephalic region. By stage 46, expressed in the olfactory bulbs, nervus terminalis, ventral hypothalamic nucleus, and ventricular zone
+Expressed both maternally and zygotically. First seen at the embryonic syncytial blastoderm stage
+Expression is restricted to mosquito host midgut stages (at protein level) (PubMed:28559405). Specifically, expression begins after gametocyte activation and peaks in mature ookinetes (at protein level) (PubMed:28559405). Not expressed in the oocyst (PubMed:28559405)
+Expression occurs in the axial mesoderm, the diencephalon, the anterior hindbrain and the anterior spinal cord. In the hindbrain, a differential expression was detected at several levels of intensity, with the highest expression in the posterior rhombomere 1 that is morphologically distinct from the anterior part, which develops into the cerebellum
+Expressed in meiocytes during meiotic prophase I
+Not detected in early embryos through stage 8. Strongly expressed in neural-specific cells at the onset of early stages of neuronal differentiation beginning at stage 9-10. Accumulates from stage 12 through the rest of embryogenesis in all neuronal cells within the brain and ventral nerve cord (VNC). Remains restricted to the central nervous system and not detected in other tissues at any stage of development
+Slightly expressed in vascular tissues, in leaves of both seedlings and mature plants, stamen filaments and developing siliques
+First expressed at hatching day, levels rapidly increase during the early postnatal period reaching a maximum by the 9th week. High levels are maintained in adults
+Expressed during the early stage of the vegetative growth phase (PubMed:16233686). Not detected in stationary phase (PubMed:11987133)
+Transcripts first detected at 15.5 dpc and peak 1 week after birth (PubMed:18804437). Transcripts accumulate during oogenesis (PubMed:18804437). During meiotic maturation, the vast majority of the transcripts are degraded and virtually none is detected by 2-cell stage embryogenesis (PubMed:18804437). The protein however persists during preimplantation up to the blastocyst stage (PubMed:18804437). At 2-cell stage, excluded from cell-cell contact regions (PubMed:18804437). Continuous exclusion from these regions during preimplantation development leads to the absence of the protein from the inner cells of the morula and the inner cell mass of the blastocyst (PubMed:18804437). Expressed in ovaries at postnatal day 2 (P2), expression peaks at P10, expression is then slightly decreased at P17 and further decreased at P21 (PubMed:31575650)
+Present during meiotic prophase I, when monopolar attachment of kinetochores to spindle microtubules is established. First appears during prophase I and localizes to several punctate dots in the nucleus until metaphase I. At the onset of anaphase I, it decreases markedly and remains absent until telophase I. Does not reappear during meiosis II
+Expressed both maternally and zygotically. Present as maternal transcripts in the eggs and display a gradual decline until 8 hours post-fertilization (hpf), being replaced by zygotic mRNAs from 12 hpf onwards (PubMed:23348054). After 24 hpf, the transcripts are mainly localized in the brain and otic vesicles (PubMed:23348054)
+In the developing brain, it is first expressed in the hindbrain and spinal cord at 10.5 dpc followed by expression in the midbrain at 11.5 dpc. By 18 dpc it is also expressed in the diencephalon and telencephalon, with a strongest expression in the hindbrain. Highly expressed in the developing olfactory bulb and in the lateral choroid plexus
+Maximally expressed during vegetative growth and gradually decreased through subsequent developmental stages
+Expressed at highest levels at 17.5 dpc in the neural layer of the retina and olfactory epithelia
+Abundant in early embryos as maternally provided but levels decline in later stages (PubMed:28626879). Ubiquitously present in developing embryos (PubMed:28626879). Higher levels of expression in female ovaries (PubMed:28626879)
+Not expressed during the earliest stages of vesicle formation (10.5 dpc). Expression begins coincidentally with the initiation of regional shape changes in the otic vesicle at 11.5 dpc and is restricted to the dorsolateral region. At 13.5 dpc, expression is limited to the inner edge of the semicircular canal epithelium, flanking the site of fusion, and this restricted expression continues at P1 (PubMed:11784868). At 14.5 dpc expression is observed in the primitive plexiform layer of the hippocampus. At P0, expression is observed in both the pyramidal and granule cell layers. Expression persistes in these cells in the adult hippocampus after their postnatal maturation. In addition, expression is also observed in the hilar mossy cells of the dentate gyrus (PubMed:15456880). At 7.5 dpc expression is ubiquitous, whereas at 9 dpc and 9.5 dpc, expression is restricted to the brain (PubMed:13129926)
+Expressed in the myotome of the somites at 8.5 dpc, onward (at protein level). Expressed in proximal region of both the hindlimb and the forelimb at 11.5 dpc, onward. Expressed during muscle maturation between 15 and 17 dpc and decreases thereafter. Not detected within the heart
+Expression starts during embryogenesis and continues into adulthood
+Expressed in the mother cell compartment at the second hour of sporulation
+Highly expressed in the youngest leaves, and levels gradually decrease in the older leaves
+In the embryo, expressed from day 9-12 and continues through later gestational development and into adulthood
+Weak increase of expression during floral induction
+Expressed in gonads from 11.5 dpc
+Expressed at low levels at 7 dpc and increases until 17 dpc. At 17 dpc, strongly expressed in thymus, lung and submandibular gland and weakly in skeletal muscle and heart (PubMed:9388475). Expressed in the developing heart at 13.5 and 16.5 dpc, during the transition from spongy to compact myocardium (PubMed:17198697)
+Accumulates in seeds upon imbibition
+Detected in siliques at nucleotide level from 6 days post anthesis (dpa) to 17 dpa. First observed in siliques at protein level 15 dpa and accumulates progressively as native isoforms or proteolytic fragments during the last week of seed maturation/desiccation. Present in dry seeds, essentially in cotyledons and hypocotyls, but disappears during their germination (at protein level)
+Expressed during a short window of embryogenesis. Expression of mRNA begins just after mid-blastula, peaks at late gastrula, and declines by the end of neurulation. Protein expression follows that of the mRNA with a time lag of approximately 2 hours: accumulates through gastrula and early neurula stages and peaks at about stage 18 (mid-neurula), then decays in a non-uniform manner, persisting about 12 to 18 hr longer than the RNA (at protein level)
+During embryogenesis, first observed at the globular stage and accumulates in cells next to the suspensor, including lens-shaped cells (PubMed:30737509). Observed at low levels in few vascular cells of the primary root (PubMed:30737509). Also expressed in lateral root (PubMed:30737509)
+Present in all stages of spermiogenesis, from round to elongating spermatids (at protein level)
+During desiccation stage of seed development increasing activity seems to be associated with appearance of isoform (PSTI II) which has a stronger affinity for trypsin
+Expression is tightly regulated. Barely present in vegetative cells and peaks at the transition to the multicellular pseudoplasmodial stage of development
+Transcriptionally regulated by MYC in the transdifferentiation of embryo pigmented epithelial cells. Expression precedes melanization
+Accumulates during floral induction and inflorescence development. Low levels during summer, slow raise after September, and peak in November and remain high until March before a progressive decrease. High expression in the whole zone of the shoot apical meristem, leaf primordia, and in the marginal area of young leaves of juvenile material and adult buds in the vegetative stage. At the floral determination stage, present at a very low level throughout the shoot apical meristem tissues. At the inflorescence forming stage, accumulates in anthers
+The phosphorylated form is present in early to mid pachytene, is absent in late pachytene and diplotene/diakinesis stages and is again present in oocytes when they reach the spermatheca (PubMed:19826475, PubMed:21901106, PubMed:22820175). The phosphorylated form is also present in sperm (PubMed:22820175)
+Up-regulated in aspidocytes, a resistant cell type induced from amoebae by a range of toxins including heavy metals and antibiotics
+First detected in testis of 18 day old mice
+Expressed in zygotes and blastocysts (at protein level). Expressed in gonads at 12.5, 14.5 and 16.5 dpc (at protein level). Expressed during fetal development at 12.5, 14.5 and 17.5 dpc and declining towards birth
+Isoform 2 (long form) is expressed only in early stages of embryonic development (cysts), while isoform 1 (short form) is also found in later embryonic stages and adults
+Expressed 48 hours after puparium formation in lateral glomeruli in the anterior and central regions of the antennal lobe, including the DA1, VA1d, VA1v, DC3. DC1, DA4l and DA4m glomeruli (at protein level) (PubMed:25741726). Expressed zygotically (PubMed:12617819). High levels of expression in embryos and pupae, and relatively low levels of expression in larvae and adults (PubMed:10973475). At cellular blastoderm stage, expressed as several segmentally separated stripes, with the anterior stripes appearing first (PubMed:12617819). At germ band extension, strongly expressed in the delaminating neuroblasts (PubMed:12617819). Expression decreases at germ band extension, remaining in a specific subset of neurons in the central nervous system (PubMed:12617819). Expressed in 6 segmentally repeated stripes in the germband (PubMed:25363762). In larvae, detected in the fat body (PubMed:12617819). In larvae, expressed in the optic lobes and the ventral nerve cord of the CNS (PubMed:23892553). Expressed 48 hours after puparium formation in ORN axons and PN dendrites that target to largely overlaping glomeruli (PubMed:25741726)
+Expressed in ciliated tissues throughout development. At gastrula stages, it is highly expressed in dorsal forerunner cells, which aggregate to form the ciliated Kupffer's vesicle. At the 12-somite stage (14 hpf), expression is restricted to the otic placode, pronephric duct primordia and floorplate. At 20 hpf, it is expressed in the pronephric duct, neural tube, nose and diffusely in the brain. Expression becomes restricted to the nose and lateral line organs at 72 hpf
+The levels follow the transcriptional activity of oocyte type 5S RNA genes during embryogenesis, present in very high levels in maturing oocytes when oocyte type 5S genes are being expressed, and in much lower levels in somatic cells where the oocyte type genes are not expressed
+Expressed during embryonic, larval and pupal stages. Highest expression is seen in late larval stages
+Up-regulated during muscle cell differentiation
+Expression declines during leaf development but remains constant throughout the flower development
+In developing excretory system, during thyroid differentiation and in adult thyroid
+At 10.5 dpc, expressed in dorsal root ganglia, spinal cord, and branchial arches. At 14.5 dpc, expressed in olfactory epithelium and cranial sensory ganglia. Also expressed in salivary glands, lungs, gut, kidney, teeth and vibrissae
+Expressed in embryogenesis from sphere to 84 h post-fertilization
+During the asexual blood stage, expressed at the trophozoite and schizont stages (at protein level)
+Abundant across the brain, expression increases progressively over the first 2 weeks after birth
+First detected at the tip of developing leaf, followed by a tip-to-base progression of the expression
+Expressed in eggs and early embryos. Detected in unfertilized eggs associated with the spindle apparatus and cytoskeletal sheets. As quickly as 5 min after egg activation, relocates to a diffuse peri-spindle position, followed 20-30 min later by localization to the presumptive cytokinetic ring. Before the blastocyst stage of development, associates with the nuclear matrix in a cell cycle-dependent manner, and also associates with the cytoplasmic actin cytoskeleton. After blastocyst formation, is found associating with cell-cell junctions, the cytoskeleton and nucleus
+Expressed during embryogenesis in seam cells as well as in the dorsal and ventral hypodermal cells where it co-localizes with actin bundles
+Highly expressed during the early (L1-L3) larval stages, lower expression levels are seen in L4 larvae, adults, and embryos
+Expressed in ring and schizont stages and to a lesser extent in early and late trophozoite stages
+Embryo; highest level before spiculogenesis
+Highly expressed and active during embryogenesis and pupation and at lower levels in larva and adult
+Expressed during ovules and embryo development and very early during the formation of lateral roots
+RAN2 transcripts mRNA interacts with PHIP1 to be distributed toward the cell plate during cytokinesis
+Negligible levels at embryonic stages 9 dpc and 15 dpc. RAB3IL1 levels increase progressively at postnatal ages P3, P7 and P13 with maximal levels in adult brain
+Detected at low levels in fetal brain, and at high levels in adult brain
+Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation
+Cyst
+Highly expressed during fruit body ripening. Levels increase during fruit body stages 1, 2 and 3, the stages of ascospore formation and maturation. Levels decrease during mycelium aging
+Starts to be expressed as aerial mycelium forms on rich solid medium after 3 days growth and in spores; only forms during growth on solid medium (PubMed:2450872, PubMed:2032288). Strongly expressed in spores (PubMed:2450872, PubMed:9822824). Most strongly expressed in spores from rich R5 media, less well in rich MS and even less well on minimal mannitol media (at protein level) (PubMed:22309453)
+Expressed starts at morphogenetic embryonic stages and continues throughout development
+Detectable in the epiblast of oocytes and throughout early mouse embryo development. In adult, expression is localized in gonadal germ cells
+Expression increased during embryonic development: there is a gradual increase in the tissues on going from 8.5 to 19 day embryos. In the breast, expression is very low in virgin mouse and quite high in pregnant mouse, but decreases in lactating and involuting breasts
+Abundant expression in developing embryos. In young seedlings, expressed in root apical meristem, and expanding cotyledons and hypocotyls. In older seedlings, still expressed in root apical meristems, but also in lateral root primordia, stipules, shoot apical meristem and vascular tissues
+Undetectable in the brain of 17 dpc embryos. Expressed in olfactory bulb from postnatal day 1 (P1) and then in cerebellum from postnatal day 14 (P14)
+Higher levels in seedlings than in mature plants
+Expressed in the developing eye and forebrain of embryos
+First expressed in the embryonic brain from 18 dpc. Levels increase during brain development until P7 and remain constant until P35. Further increase in adult brain (at protein level)
+Expressed by both ovaries and testes on the day of birth, just prior to the onset of testicular differentiation, until at least 8 days after birth by which time the ovary also has begun to sexually differentiate
+The amount of DSPG per cervix increases 4-fold during pregnancy, then falls precipitously within 1 day post partum
+No expression in embryo at 9.5 dpc and 10.5 dpc. Expressed in tooth epithelium at 13.5 dpc. At the early bell stage, Expression in preameloblasts and preodontoblasts
+Relatively abundant in etiolated, light-shifted, and young (plastochron 1 to 5) leaves
+At 9.5 dpc, detected in placodes, ectodermal thickenings where organs or structures will develop. Expression levels increase substantially between 9 and 14 dpc
+Expressed during meiosis and ascospore formation. First expressed at the beginning of meiosis I, and is highly expressed prior meiosis II
+Expressed in developing seeds from 15 days after flowering (DAF) to 45 DAF
+In embryo sac, detected as early as the one-nucleus stage. In older embryo sacs, highest expression in antipodal cells
+Expressed both maternally and zygotically. Highly expressed in embryos and pupae, and at lower level in larvae. In adults, it is expressed at higher level in females
+Higly expressed in late planulae, primary polyps, and both adult males and females (at protein level) (PubMed:31134275). Consistant with protein expression, transcripts are moderately expressed in gastrulae and highly expressed in early and late planulae, metamorphosing planulae, primary and juvenile polyps, and both adult males and females (PubMed:29424690, PubMed:31134275). Low expression in unfertilized eggs and blastulae (PubMed:31134275)
+Late embryonic, larval and adult stages (PubMed:10774727). Expressed in the interneuron PVT during embryogenesis (PubMed:12490565). Expressed in the BDU neuron in the three-fold embryonic stage at about 430 minutes of development (PubMed:26096732)
+Expressed postnatally in the retina. The expression in the retina coincides with one of the photoreceptor specific genes. Expressed in forebrain of 9.5 dpc embryos and in whole brain of 11.5 dpc embryos
+Detected in fusing myoblasts during muscle cell differentiation. Highly expressed in young myotubes that are in the process of assembling and remodeling myofibrils. Subsequently, levels decrease during myotube maturation
+Expressed at low levels. First detected after cellularization, in the early epidermal tissues of embryos undergoing gastrulation. At later stages of embryogenesis, strongest expression is in the gut, and there is also expression in the central nervous system and perhaps the peripheral nervous system
+Expressed in early gastrula period, subsequently increases to a high level in late stage of gastrula period (bud stage) and lowers until the hatch period. Expressed in developing central nervous system of embryos, especially in mid-brain and mid-hind brain boundary. Seems to be restricted in central nervous system, especially in mid-brain and mid-hind brain boundary
+Detected muscle syncytia in embryonic stage 14 and early stage 15. At mid stage 15, localizes at the leading edge of growing myotubes. In the ventral ends of VO5 and VO6 muscles enriched at the base of membrane protrusions at the leading edge of growing myotubes, while it is less expressed in filopodia. In the late stage embryo, concentrated at all muscle attachment sites, although subtle variation in expression and/or localization may be observed in different muscles subsets. Remains enriched in myotubes until the end of embryogenesis (at protein level)
+Expressed in the Q neuroblast lineage
+Detected only in rapidly dividing and invasive tachyzoites
+Detected at 10 dpc and 12 dpc in developing brain, but does not appear more prominent in the neuroepithelium compared to the surrounding tissue
+At 10.5 dpc expressed in otic vesicle
+Is not expressed in mature serosal or mucosal mast cells and is expressed only transiently at an early stage of in vitro mast cell differentiation
+Expressed at the leading edge (LE) cells and in two pairs of discontinuous stripes on the epidermis of each segment at stage 13. Expressed in the anterior and posterior spiracles, the pharynx and the mouth tip at stage 16
+Strongly expressed in fetal thymus at weeks 17-24 of gestation. Undetectable in bone marrow and fetal liver
+In the inner ear, expression detected in the otocyst at embryonic day 3 and in the whole cochlea at E 6. Expressed throughout embryonic development and adulthood
+Isoform B and isoform C are expressed zygotically from the early neurula stage, with expression maintained until the tadpole stage
+Expressed both maternally and zygotically with continuous expression from the zygote to the early larva. Expression dramatically decreases at 30 and 50% epiboly stages, then increases from midgastrulaion onwards, being maintained at a high level until the protruding-mouth stage
+Expressed during flower development, just before anthesis. Undetectable 24 hours after anthesis
+During the L3 larval stage, transiently expressed in the anchor cell, in rectal epithelial cells D, VL, and VR, in B and in Y, and in several neuronal cells (PubMed:11784109). During the L4 larval stage, expressed near the vulva and the uterus, with expression lining the lumen of the uterus and portions of the vulval lumen including the vulval toroid cells vulB and vulE (PubMed:11784109). During the L4 larval stage, not expressed in the vulval toroid vulF (PubMed:11784109)
+Specifically localized within meiotic cells in the anther locules, transiently, only during late meiosis
+Isoform SERCA1A accounts for more than 99% of SERCA1 isoforms expressed in adult skeletal muscle, while isoform SERCA1B predominates in neo-natal skeletal muscle
+Only weakly expressed in developing embryo except for developing teeth, eye and salivary gland. In the developing eye, from 12.5 dpc, expressed in the future neural retina, in both the inner and outer cell layers. In the developing teeth, strong expression detected in the developing incisor teeth at 14.5 dpc. Expression localized to the mesenchyme of the dental follicle surrounding the enamel organ only at the early cap stage. Highly expressed in the branching epithelium of the salivary gland
+Expression is concentrated in the notochord with strongest expression in the embryo at stages 17 to 27, and slightly less in the endoderm. It is present in the oocyte and expression increases from late gastrula. Accumulation peaks by late neurula and is greatly reduced by the tadpole stage
+Detected throughout the developing heart
+During embryogenesis expression is restricted to developing Ch neurons and absent from other ciliated sensory neurons. In the pupal antenna, expressed exclusively in the Ch neurons of Johnston's organ
+In the embryo, highest expression at 2 hours post-fertilization (hpf) with levels decreasing in later stages
+Maximal expression during the first day after pupal ecdysis
+Fades out gradually during aging
+Expressed throughout develpoment
+Expressed in specific patterns in the inflorescence meristem and developing flowers. Present throughout the inflorescence meristem and in young floral meristems through stage 4. Around stage 5, present within the developing organs of the inner three whorls but absent from sepals. At later stage of floral development, present at a low level in the gynoecium but accumulate strongly in developing ovules
+In retina, expressed on ganglion cell fibers as soon as they begin to extend their axons
+Both isoform 1 and isoform 2 are expressed both maternally and zygotically. Present in all embryonic stages including early cleavage stages, with levels decreasing during gastrulation. Expression is then up-regulated at stage 25 and persists until stage 45
+Expressed at all stages of mammary gland development with slightly higher levels observed during pregnancy and lactation. At 4 weeks, expression levels of isoform 1 and isoform 2 do not differ in pancreatic lymph nodes of nonobese diabetic (NOD) mice compared to NOD.B10 mice which do not develop diabetes. However, at 12 weeks, expression of isoform 1 is down-regulated while expression of isoform 2 is up-regulated in NOD mice but not in NOD.B10. There is no difference in expression levels at 12 weeks in spleen
+First detected at embryonic day 5 (5 dpc) in both apical and basolateral membranes. By 14 dpc the distribution is restricted to the basolateral surface of retinal pigment epithelium. Restricted to the basolateral membrane in adult
+Expressed in growing cells and throughout development. Levels increase during mound formation (12 hours) and peak at approximately twice the level seen in growing cells before decreasing again at the start of culmination (16 hours)
+Detected in the ventricular zone of the lateral ventricle in brain from 13.5 dpc and 17.5 dpc embryos
+Shows a graded distribution in the primitive streak and in cells lateral to it. It is not detected in cells along the A-P axis of the embryo anterior to the primitive streak, except at 7.5 dpc when there is transient expression in the head process. The highest levels of expression are found within the proximal (posterior) portion of the primitive streak and cells near it, with expression levels decreasing more distally (anteriorly)
+Expression begins at the 2-fold embryonic stage and continues throughout larval development and adulthood. In larvae, expressed in the hypodermis but not in seam cells
+Expressed uniformly throughout the embryo from 7.5 to 9.0 dpc, except in the distal allantois and developing heart. Gcn5l2 expression is down-regulated after 16.5 dpc, but is later up-regulated in specific adult tissues
+Expressed in the head after the twofold stage of embryonic development (PubMed:11122376). Expressed in neurons in the head and ventral nerve cord in all larval stages (PubMed:11122376). Expressed in RMED, RMEV, RMER and RMEL head neurons of L1 stage larva (PubMed:11122376). Expressed in the tail of L4 stage larva (PubMed:11122376)
+At 10.5 dpc, expressed in brain and developing lens. At 12.5 dpc, the expression is extended to liver. By 17.5 dpc, expressed abundantly in brain, spinal cord, heart end liver and moderately in salivary gland, lung, kidney, gut and bladder (at protein level)
+At 9.5 dpc, expressed weakly in heart. Higher levels of expression detected at 12.5 dpc and 15.5 dpc in both cardiac and skeletal muscle
+First detected at 7.5 dpc, reaches its peak around 9.5 dpc and declines considerably after 10.5 dpc
+Expressed throughout development and adulthood but abundance declines with age
+Expressed throughout the cell cycle independently of DNA synthesis
+The level of expression increases during meristem growth, reaches a maximum at 5 days post germination and subsequently remaines constant in time
+Present during flower development prior to fertilization. At early stages of ovule development, the expression is uniform throughout the ovule. At a later stage, is localized adjacent to the embryo sac. When the flower opens and pollen is released, it is found in the whole ovule and in the outer layer of the placenta
+First expressed at the 1- to 2-somite stages posterior to rhombomere 5 (r5) of the developing hindbrain. By the 3- to 4-somite stages, the anterior expression limit is at the r4/r5 boundary. At 5- to 10-somite stages, expressed at high levels in r5 and r6. From the 20- to 30-somite stages, expressed weakly in r4
+Splicing is temporally regulated. Isoform 5 is expressed both maternally and zygotically, whereas isoform 1, isoform 2, isoform 3 and isoform 4 are exclusively zygotic. Expression is highest in embryos from stage 12 on, with expression levels remaining constant throughout embryogenesis
+Expressed during embryogenesis, postnatal stages and in adult
+In spermatocytes, synaptonemal complex-associated Ccnb1ip1 foci are detected by early pachynema and their number peaks during midpachynema. In late-pachytene nuclei, Ccnb1ip1 foci number descrease. At the onset of diplonema, foci are no longer detected (at protein level)
+Expressed in trophectoderm-derived cells of the placenta
+Expressed in the lungs from 23 weeks onwards, expression increases during the third trimester resulting in significantly higher expression at birth
+Expressed in mature root vasculature and throughout root meristem
+Expressed during ovule development. First detected in the ovule primordia and later in the inner and outer integuments, nucellus tissue and the inner layer of the carpel wall
+Expressed during vegetative growth and up-regulated at early development, with a peak at 6-9 hours of the aggregation stage and then declined abruptly from 16 hours of development
+Expression is high in the embryonic and early postnatal stages
+Expressed in embryonic ovaries at embryonic day 16.5 (at protein level)
+Expression is gradually but significantly up-regulated during adipocyte differentiation
+Exclusively in the anterior neural fold of neurula stage embryos. By the tailbud stage, the protein is localized in specialized cephalic ectoderm, in a region probably corresponding to the hatching gland
+Expressed at highest levels in epicotyls and hypocotyls of 14-day seedlings. Detected at low levels in stem apices and root tips of 14-day seedlings, and in 2-day etiolated seedlings. Not detected in 75-day plants
+First expressed by early gastrulation (stage 8). Expression peaks during neural induction and early organogenesis
+At the primitive streak stage (7.0 dpc), expressed in the emerging mesoderm. By 8.0 dpc, expressed exclusively on the left side of developing embryos with expression predominantly in the lateral-plate mesoderm (LPM). Weak expression in the prospective floor plate (PFP)
+In seedlings, observed in the root tips, root vascular tissues and at the junction region of hypocotyl and root. In flowers, mainly detected at the connection of petiole and stem, and in young flower buds. Also present at low levels in sepals and pistils
+Expressed at low levels in the mid-aggregation stage, followed by a rapid increase that coincides with the completion of aggregate formation. Expression is greatest in cells at the periphery and the rear end of the migrating slug
+Expression in 8.5 dpc-9.5 dpc embryos is observed in embryonic blood vessels including the dorsal aorta, intersomitic arteries and the forming vascular plexus in the head as well as the cardiac outflow tract. By 10.5 dpc-11.5 dpc embryos expression is found in association with the all recognizable blood vessels and in association with cells lining the heart chambers. At 10.5-days embryos expression is associated with syncytiotrophoblasts and cytotrophoblasts as well as endothelial cells associated with blood vessels in the decidua. Expression decreased after mid-gestation from 15.5-day embryos
+Seedlings and mature plants
+Expressed in the mammalian blood stage form and insect procyclic form (at protein level)
+Expressed during the stationary phase of cell growth
+In developing flowers, observed in gynoecia of young flowers, but later confined to the distal end of filaments in old flowers
+At the 10-somite stage, barely expressed in the paraxial mesoderm. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit at the rhombomere 6/7 boundary
+Expressed in fetal kidney, cochlea, eye, heart and lung
+Expressed in embryo at 9 dpc, increases progressively to a peak at 14 dpc and gradually decreases until 19 dpc
+High expression in source leaves, but almost undetected in sink leaves
+Increases in abundance as gestation advanced. Predominandtly expressed in the junctional zone during the latter third of gestation
+Expressed in the hypodermal cells of the tail and head, the seam cells, and in the hyp7 syncytial hypodermis in the larval L4 stage, and in the young adult (PubMed:24569038, PubMed:29604168). Not expressed in the cells of the developing vulva (PubMed:24569038)
+At larval stage, present in cell bodies of the ventral ganglion and in neuropil (at protein level)
+At the early gastrula stage, expressed mainly in the entire animal hemisphere. During neurulation, its expression becomes restricted to the anterior neuroectoderm. At the tailbud stage, expressed in various anterior regions including the anterior central nervous system (CNS), otic vesicles, and branchial arches
+Accumulates in floral primordia and is maintained at a maximal level at the floral bud stage of arrest
+Disappears after the cartilage development
+Expressed very early during embryo and endosperm formation and during the proliferative stage of endosperm development at 4 days after pollination
+In the developing cerebellum expression is high at birth and declines over the first 3 weeks. At P7 highly expressed in granule cell precursor cells in the external granular layer and mature granule cells of the internal granule layer
+Expressed in the apical side of the neuroblastic layer (NBL) of the retina at 14.5 dpc and 17.5 dpc. At 16.5 dpc, present in rib cartilage and hair follicle (at protein level)
+Expressed at all developmental stages. Highly expressed in embryos with levels decreasing during larval development and increasing as animals reach adulthood
+In the developing kidney, only present in the uncommitted mesenchyme and absent from more differentiated structures including renal vesicles and comma-shaped bodies. First detected in the metanephric mesenchyme at 10.5 dpc. After 11.5 dpc, observed in mesenchymal cells surrounding the tips of ureteric buds in the metanephroi. At 11.5 dpc, also detected in limb buds and central nervous system. At 14.5 dpc, strongly expressed in the nephrogenic zone
+Expressed maximally during the exponential growth phase
+Expressed in the otic vesicle at 1 days post fertilization (dpf) (PubMed:26365339). Expressed in mesenchyme pectoral fins surrounding the cartilage of the endoskeletal disc, and in the epithelial cells of the oral cavity at 3 dpf (PubMed:26365339). Expressed weakly in the pronephric duct and the liver at 3 dpf (PubMed:26365339)
+Expressed throughout the oocyte development from stages I to VI (at protein level). Levels begin to increase in the developing nervous system at stage 12 (at protein level). At the neural tube stage, expression is detected throughout the developing neural epithelium and in the cells migrating out of the mesencephalon and rhombencephalon, eye, neural tube, otic vesicle, pronephros, branchial arches and blood islands (at protein level). Detected in low levels throughout early embryogenesis
+Expressed at high levels at 0-1 hour and from 5-17 hours. Also expressed at high levels in early pupae
+Continuously expressed during embryogenesis
+In the embryo, it is expressed in the developing eye, limbs and brain (PubMed:31402090). Expression is observed in the lens, retina, lips of the optic fissure closure and regions of the conjunctiva at Carnegie stages (CS) between CS15 and CS21. As eye development progresses, the stronger signal observed in the retina progressively shifts from the inner toward the outer retinal layers (PubMed:31402090). In the developing hand, expression is strong at CS15. At CS19 and CS21, after the digits have begun to form, strong expression is seen in the mesenchyme surrounding the developing cartilage (PubMed:31402090). In the brain, it is expressed in the primitive ventricles at CS17 and CS19, hypothalamus and medulla at CS17, and metencephalon at CS19 (PubMed:31402090). Strong expression is also observed in the pharyngeal arches, including the mandibular process and tongue at CS17 (PubMed:31402090)
+Expressed throughout tassel growth up until mature pollen is produced in the anthers
+Found in flexible cuticles of all three metamorphic stages of H.cecropia
+Expression rises within the dentate gyrus and temporal cortex from the neonatal period to infancy, declines markedly in adolescence, and declines further with aging
+Expressed throughout embryonic development (PubMed:15659483). In embryos, highly expressed after the first cleavage until the early 3-fold stage in one bilateral row of epidermal hyp5, H0-H2, V1-V6 and T-cells (the seam cells) (PubMed:15659483). In later embryonic stages, expressed in anterior neurons and in the DA1 and DD1 motorneurons after hatching (PubMed:15659483). Expressed in seam cells at all larval and adult stages (PubMed:19607822). In dividing seam cells at the L2 larval stage, expressed equally in both daughters and expression in the anterior daughter ceases when it fuses with hyp7 (PubMed:19607822)
+Shows seasonal variation in expression levels with maximal levels from November-March (at protein level). Shows diurnal fluctuations in expression level, with peak levels at dusk, under conditions of natural light but not under conditions of continuous light: may not have true circadian rhythmicity
+Before reinitiation of the DNA replicational activity
+Expressed in the inner and outer pericarps of developing fruit at 20 days after flowering (DAF) (PubMed:21175894). Expressed only in the inner pericarp from 86 to 126 DAF (PubMed:21175894)
+Found in the large cell variant (LCV) stage, undetectable in the small cell variant (SCV) stage; at protein level. LCVs are more metabolically active than SCVs
+Low level expression from embryos at comma stage to adult; maximal level in dauer larvae
+Low expression in fruit until the onset of peel color change, and then increases toward ripening
+Very low expression in protonema. Expressed in gametophores, with a maximal level in mature gametophores
+Detected from the 6-somite stage onwards. Expressed in cells near the anterior part of the yolk sac at 48 hours post-fertilization (hpf). Expression refines to the intestine by 72 hpf
+Accumulates in tissues undergoing senescence (PubMed:20712629, PubMed:22530652). In roots tips, strongly expressed in the cortex undergoing vacuole biogenesis (PubMed:22530652)
+Induced during germination and expressed during hyphal growth (at protein level) (PubMed:33462434). Not expressed in spores (at protein level) (PubMed:33462434)
+Found in the male and female gonads of early embryo and, after birth, it is found only in the testis. Expressed in primordial germ cells (PGCs) until 14.5 dpc in male gonad and until 13.5 dpc in female gonad; after this age its expression disappears and then it is found after birth only in male germ cells
+Expressed in postmeiotic cells
+Constitutively expressed at low levels throughout development
+Expressed specifically in the vasculature since the early stages of embryogenesis. At the globular stage of embryogenesis, detected in the four innermost cells, which are the precursors of the vascular tissue. During the heart, torpedo, and nearly mature stages, expressed in the procambium of the cotyledon shoulders, prospective hypocotyl, and embryonic root. In seedlings, mainly localized in meristematic tissues (e.g. shoot apical meristem SAM, root tips, and growing leaf and lateral root primordia), especially in vasculature. Present in all the vasculature and the shoot apical meristem (SAM) of the adult plant. In flowers, localized in carpels and developing ovules. In the root tips, expressed in the central cylinder
+Expressed in the developing intestine both prior to and during remodeling (stages NF54 to NF66)
+Not detectable in newborns. First detected 23 days after birth. Levels increase up to 28 days after birth, and remain constant in adults
+Undetected at postnatal day 1 (P1) through P7. Expressed weakly at P10, rapidly increases during the period P14 to P21 and reaches adult levels by P28
+Expressed postnatally in the hippocampus, neocortex, olfactory bulb and cerebellum. Expressed in the hippocampus from P0 to P15. Expressed in the posterior region of the neocortex at P4, the anterior region at P9, and is then lost by P15. Expressed in the cerebellum from P0, specifically within the external granule layer (EGL) which contains granule cell precursors. By P7 expression is distributed throughout the EGL and is reduced in the inner granule cell layer (IGL) where granule cells finally differentiate. Expression in the IGL continues to diminish up to P15, when granule cell neurogenesis is complete
+In the embryo expressed in the neural folds and the presumptive eye at stage 18. At stage 24 expressed in multiciliated cells of the epidermis. Also detected in the brain, spinal code, eye, olfactory placode, and cloaca. At stage 32 expressed in the pronephric duct, nephrostrome, cloaca, somites, posterior spinal cord, eye, branchial arch, otic vesicle, and fore-, mid-, and hindbrain
+In brain, detectable as early as 12 dpc and the level increases persistently through later embryonic stages to the adult age (PubMed:17287360). In the hippocampus, undetectable at postnatal day 1 (P1), detected at P7, the levels peak between P15 and P21 to remain at a high level during adulthood (PubMed:28096412)
+Expressed in post-mitotic raphe serotonergic neurons. First detected at the 20 somites stage
+Expressed in developing gut endoderm, cardiac progenitors and heart. Expression restricted to the very narrow development period between stages 8.0 and 11.5 dpc. First detected at 8.0 dpc in the endoderm of the lateral walls and lip of the forming foregut pocket, directly juxtaposed to cardiogenic mesoderm. At 8.5 dpc, expressed in the forming pharynx, predominantly in its lateral aspects where pouches will form. From 8.5 to 11.5 dpc, expressed in the ventrolateral endoderm of all forming pouches, as well as in juxtaposed arch ectoderm and mesenchyme. Expression levels decrease as pouches matured. Also expressed in the ventral hindgut endoderm from 9.5 dpc and in a short segment at the foregut-midgut junction spanning the proximal parts of the common bile and pancreatic ducts
+Between 8.5 dpc and 10.5 dpc it is found in the neuroepithelium of the midbrain and ventral forebrain, as well as in the spinal cord. Between 10.5 dpc and 12.5 dpc its expression pattern changes from a restricted to a widespread zone, it is then found at variable levels in the ventricular zone in all regions of the brain, where is expressed in a subset of p2 progenitors that can give rise to either V2a or V2b interneuron subtypes. From 12.5 dpc to postnatal stages it is also expressed in cells outside of the ventricular zone through the brain, and in addition it is also expressed during development of the olfactory epithelium and neural retina. At 12.5 dpc, it is highly expressed by differentiating enteric neurons in the mesenchyme of the stomach. At 14.5 and 16.5 dpc, it is also expressed in the epithelium of the glandular stomach (PubMed:18173746)
+Detected in male gametocytes and gametes, but not in female gametes, nor in the asexual stages present in host erythrocytes (at protein level)
+Specifically expressed in mitotically dividing cells of seedlings
+Detected at 17 dpc in the brain. Expression increases during postnatal life and reaches a plateau at approximately P10 (at protein level)
+During embryonic development, it is detected almost exclusively in the skeletal muscle, and at lower level in brain. In skeletal muscle, it is induced after myoblast differentiation, when myotube formation is promoted
+Expressed in embryo at 15 dpc (at protein level). Expressed in embryo at 8, 10, 11, 13, 14 and 15 dpc
+Expressed in cotyledons during embryogenesis. Expressed during ovule development (PubMed:25378179)
+Initially detected in the tapetum and microsporocytes during meiosis. Highest expression during the tetrad stage. After microspores were released from tetrad, slightly detected in the tapetum and microspores
+Expressed at detectable level on 7 dpc, at increased level on 11 dpc, at maximal level on 15 dpc. Then, expression decreases from 17 dpc. Expressed in the developing neural tube
+Low expression at 7.5 dpc and 12.5 dpc in the yolk sac
+During early stages of development (9-18 hours post fertilization, hpf) has weak and ubiquitous expression. Expression is restricted to brain at 24 hpf. At the hatching stage (48 hpf), detected in heart but not in brain
+Expressed in developing embryos from the pre-comma stage through to hatching (PubMed:20081192). Most highly expressed in larval stage L1 and gradually decreases into adulthood (PubMed:20081192). In larval stages, expressed throughout development in the ventral nerve cord, intestine, gonadal distal tip cells (DTCs) and subsets of head and tail neurons, most strongly in head neurons ASI and ADL (PubMed:20081192)
+Expressed in fetal lung and kidney
+Detected in all cell layers of the dorso-medial part of the embryonic olfactory placode and olfactory epithelium. First detected in olfactory placode on embryonic day 11.5. Detected in olfactory placode on embryonic day 12, 14, 16 and 18
+Detected in embryonic myocardial cells and in the developing heart tube. Detected in embryonic dorsal vessels and tracheal system
+A late competence gene, expression is enhanced in the presence of ComK
+Expressed during the asexual blood stage; expression begins at the late ring, early trophozoite stage, increases in the mid-trophozoite stage, and persists throughout the schizont stage (at protein level)
+Expressed in late embryos and pupae
+Expressed both maternally and zygotically. Most abundant in stage I oocytes. Expression fades away at stage 7 and then is elevated at the late blastula stage (stage 9), which continues during neurulation. From stage 25 onwards, expression levels decrease
+Expressed in the hypodermis from embryogenesis to adulthood
+Expressed during the parasite blood stage, in trophozoites (at protein level)
+Expression detected from the 50-cell stage of embryogenesis through to adulthood. In the adult, expression increases two-fold between day 4 and day 14
+Expressed from late embryogenesis onwards (PubMed:1652526, PubMed:15733671). Temporally expressed in anterior and posterior cells of the intestine in newly hatched larvae (PubMed:15733671)
+At stage 15, detectable in the anterior and ventral mesoderm near the heart primordia. At stage 22, the central band of expression in the lateral plate mesoderm is confined to the mid-embryo. By stages 28-30 (late tailbud stages), the region of expression in the lateral plate mesoderm has expanded into a symmetrical arc of ventral and lateral expression, which fuses in the midline where the straight heart tube has formed. At stage 33 (beginning of heart looping), expressed in the heart, lateral mesoderm and branchial arches. At stage 37, uniform expression in the myocardium and cardiac outflow. Most abundant in the heart and outflow tract at stage 47 (tadpole stage)
+More highly expressed in L1 larvae than in eggs and adults
+Both maternal and embryonic transcription (PubMed:9622625). Transcribed from both the maternal and paternal genome, at least in eight-cell stage, late morula and blastocyst (PubMed:9622625). Expressed during all stages of oogenesis, from immature oocyte to mature oocytes in the antral follicles (PubMed:9622625). Expressed at low level in late two-cell stage (49 h) zygote, increasing slightly between the late two-cell stage and the eight-cell stage (77 h), then increasing dramatically by about 10-fold at the morula stage (88 hours) (PubMed:9622625). Early egg cylinder stage embryos, at 5.5 days post coitum (dpc) show strong expression throughout the diploid ectoplacental cone (EPC) and the extraembryonic ectoderm, but no expression in the giant cells or the embryonic ectoderm or primitive endoderm (PubMed:9622625). Expressed transiently at 7.5-8.5 dpc at low levels in the embryo (PubMed:8090202). Expressed at 7.5-8.5 dpc at high levels in extra-embryonic tissues, the chorion and the EPC, but not detectable in secondary giant cells or the allantois (PubMed:8090202, PubMed:9622625, PubMed:10611232). At 9.5-10.5 dpc, expression persists in both the labyrinthine layer and the outer spongiotrophoblast layer of the placenta, with stronger expression in the spongiotrophoblast (PubMed:9622625). By 12.5 dpc, expression in the spongiotrophoblast layer is restricted to only a subset of cells (PubMed:10611232). Overall expression in the placental layers declines after 10 dpc, declining further by 15.5 dpc (PubMed:9622625)
+Expressed throughout embryogenesis and in adulthood. During embryogenesis, expression is high at transition phases of mesenchymal cell differentiation such as from mesenchymal cells to chondrocytes and from mesenchymal to mesothelial cells. Expressed throughout all stages of humerus bone formation. During lung development, expressed in all mesenchymal cells at the early pseudoglandular stage. Expression is rapidly lost from the mesenchyme of the lung interstitium during the mid-to-late pseudoglandular stage but continues throughout life in the mesothelial pleural cells
+Detected at embryonic days 11, 15 and 17
+Expressed throughout plant development
+Present during gametogenesis and throughout embryogenesis (at protein level)
+Expressed in both adult and embryonic CNS
+At 13.5 dpc, strongly expressed in the developing vasculature of the endocardium. At P17, expressed throughout the retina (at protein level). At 9.5 dpc and thereafter, prominently expressed in the vasculature, including in ventral and dorsal aorta and the caudal artery. In developing heart, detected in endocardium and blood vessels of the ventricle, bulbus arteriosus, and atrium. Also highly expressed in hypertrophic cells of the developing bone. In adult, expressed prominently in brain, including in hippocampus, cerebellum, pons, thalamus, cortex, and olfactory bulb
+Expressed during development; especially at 12 hours of development
+Highly expressed at the embryonic stage, with decreasing expression from L1 onwards
+Expression of isoform 1 and isoform 2 is up-regulated in testis at postnatal day 17; isoform 1 maintains similar expression levels until the adult; expression of isoform 2 peaks at postnatal day 22 and is barely detected in the adult
+Isoform 1, isoform 2 and isoform 3 are detected in maturing and mature brain, whereas isoform 4, isoform 5 and isoform 6 are expressed in embryonic and early postnatal brain. All isoforms are expressed in heart
+Expressed throughout development with highest levels in adult females and preblastoderm embryos
+Highest expression at 16 dpc when callosal axons are beginning to cross the midline. At 17 dpc-18 dpc, when the majority of axons are projecting away from the midline, expression is observed but at a lower level. Present on the cell bodies of neurons in cortical layers at 18 dpc
+Shows a bi-phasic developmental regulation. Present in growth phase cells as well as in early aggregating cells, but the levels drop significantly during the slug stage. Protein levels rise again at later multicellular stages of the development to higher amounts than in growth phase cells, and the protein is still detectable in significant amounts in fully developed fruiting bodies (at protein level)
+Expression increases between 20 and 48 hours after fertilization and is detected in sprouting intersegmental vessels (PubMed:21835952). At 24 hours after fertilization, expressed throughout the embryo with high levels in eye, mesencephalon and hindbrain boundaries (PubMed:25959397)
+Detected in 7-day and 17-day embryos
+Expressed in larvae and pupae, with highest levels in later larval and early pupal stages. Very low expression in 1-day-old adults
+Expressed in the intermediate zone and cortical plate of the cortex at 15.5 dpc
+Widely expressed in embryos at 7 dpc
+Predominantly expressed in the brain at 14 dpc and on postnatal day 1
+Up-regulated during postnatal brain development
+Elevated during early neuronal development. Expressed in dorsal root ganglia and peripheral and central processes of sensory neurons at 13 dpc. Also expressed in neurons and axons of the embryonic tectum at 13 dpc, and in the cerebral cortex at 16 dpc. Highly expressed in layers containing hippocampal neurons at P1, with expression becoming undetectable by P8
+Expression initiates during mid-embryogenesis primarily in post-proliferative hypodermal cells and neurons in the head, ventral cord and tail, then declines until hatching where it is mainly seen in seam cells. Expressed throughout larval development in several blast cell linages. In the P lineage, expression is restricted to proliferating cells, whereas it persists in somatic gonads and seam cells. Expressed in uterus and intestine and to a lesser extent in spermatheca
+Expressed only in female gametocytes
+Highest expression in endosperm at 21 days after pollination
+Associated with the centrosome throughout the cell cycle (PubMed:8834802). During mitosis, it is associated with the centrosome and the mitotic spindle (PubMed:8834802). At anaphase, it is only localized to centrosomes (PubMed:8834802). Isoform 4 is highly expressed in postmitotic cortical neurons during neurogenesis (PubMed:27565344)
+First expressed after neurulation (stage 18), and expressed throughout development
+Throughout development, from embryo to adult
+Expressed throughout development. Weakly or not expressed in some adult organs
+During the stages 11.5-13.5 dpc it is expressed in most tissues of the embryo. Within the telencephalon, it is exclusively expressed inside of the ventricular zone (VZ). The expression reaches its peak by 15.5 dpc and starts to decrease by 18.5 dpc, and is not detectable in the adult brains. Most of the cells expressing it were found in the lower part of the ventricular zone
+Ubiquitously expressed in mouse embryo
+Expressed during parasite asexual blood stages, specifically in late trophozoite and schizont stages (at protein level)
+Produced during parasite asexual blood stages, specifically at the merozoite stage just prior to egress (at protein level)
+In the embryo, expression is detected from day 7 with highest levels between days 11 and 15
+Low levels in early gestation. Highest levels expressed during mid gestation. Levels decrease in late gestation and remain at this level in the adult
+Present throughout development. During the cell cycle progression, levels in egg extracts do not change. Appears during the first 12 hours of development, and they further increases significantly between 12 and 24 hours. Not present in oocytes I-VI but it is detected at maturation. The level of protein remains constant from mature oocytes to stage 8.5 embryos but increases after mid-blastula (at protein level)
+Maternally expressed in the at four-cell stage. Highly expressed in the developing anterior neural plate since tailbud stage. During the segmentation period, 24 hour post fertilization (hpf), expression is still enriched in cell clusters at prosencephalon and mesencephalon
+Expressed both maternally and zygotically. Expressed throughout embryonic, larval, pupal and adult stages
+Expression was detected throughout embryonic development as early as 8.5 dpc
+Expression is first seen at 5 hours of development during aggregation, reaching peak expression at slug stage (15 hours)
+Expression is restricted to embryogenesis
+In an vitro adipocyte differentiation system, induced at the protein and RNA levels shortly after exposure to the induction mixture. Levels peak before PPARG induction and rapidly decrease during later stages of differentiation
+Expressed in branchio and viscero motoneurons at 10.5 dpc. Expressed in the nucleus ambiguus (nA) motoneurons at 15.5 dpc. Expressed in the brainstem respiratory rhythm generator (RRG), including two interacting neuronal networks constituting two oscillators: the pre-Boetzinger complex (preBoetC) at 15.5 dpc and the embryonic parafacial respiratory group (e-pF or pFRG) at 14.4 dpc, that contributes both to motor coordination of the respiratory apparatus and confers central chemosensitivity, as well as in cranial motoneurons targeting chest muscles that control the upper airway opening. Expressed in the developing urinary tract. Expressed in ureteric bud (UB) stalk at 11.5 dpc. Expressed in mesenchymal cells along and around the UB stalk, and absent from the UB epithelium and in scattered cells within the metanephric medullary stroma at 12.5 dpc. Expressed in mesenchymal cells in proximal ureters at 14 dpc, preceding the smooth muscle precursor cells differentiation and the expression of contractile proteins from 15 dpc. Expressed in mesenchymal cells of the ureter and renal pelvis, and in renal medullary stroma, in the mesenchymal cells adjacent to the epithelium and in the peripheral mesenchyme where smooth muscle (SM) starts to differentiate; the outer rim of nephrogenic mesenchyme was negative at 15.5. In the bladder, expressed in the submucosal loose connective tissue adjacent to the epithelium and in the detrusor SM layer at 18.5 dpc
+At 26 hours post fertilization (hpf), expression is ubiquitous (PubMed:28972538). Later in development, expression is more pronounced in the anterior part (PubMed:28972538)
+Constitutively expressed at low level during leaf development, but up-regulated during senescence, when the leaf color changes from green to yellow
+First expressed at embryonic day (E) 11.5 in the olfactory epithelium and at 13.5 dpc in the vomeronasal organ. Expression increases thereafter, reached maximal level at P14, and strong expression level is maintained into adulthood
+Expression detected from 8.5 dpc through to 13.5 dpc, with a considerable increase in expression apparent at 13.5 dpc (PubMed:9337129, PubMed:18505825, PubMed:20596238). Expressed throughout the central and peripheral nervous system, as well as the mesenchyme of many developing organs between 12.5 dpc and 14.5 dpc (PubMed:18403418). Abundantly expressed in the developing cerebral cortex, thalamus, hippocampus, cerebellar cortex, and ganglia in the brain at 14.5 dpc and 16.5 dpc with low expression at 18.5 dpc (PubMed:18505825). Abundantly expressed in the gut epithelium at 14.5 dpc (PubMed:18505825). Abundantly expressed in the olfactory epithelium with low expression in skin, spinal cord, kidney, heart, muscle, cartilage from 14.5 dpc to 18.5 dpc (PubMed:18505825). Very low expression in intestine and lung, with no expression detectable at 18.5 dpc (PubMed:18505825). Abundantly expressed in the subventricular zone of the brain at 18.5 dpc (PubMed:18505825). Expressed in the brain at postnatal day 2 (PubMed:18403418)
+Expressed in expanding premature leaves. Decreased expression in oldest leaves. Also detected in roots
+Expressed in both arterial and venous vascular endothelium in embryos, although more strongly in arterial vessels. Highly expressed in the developing outflow tract of the heart and later is expressed in developing heart valves
+In the thymus, not expressed at 13.5 dpc but present at 16.5 dpc and postnatal day 1
+Highly expressed from 6.5 dpc plus deciduum. Also expressed, but to a lower extent, in placenta from 11.5 dpc and 13.5 dpc. Not expressed at 8.5 dpc and 11.5 dpc in embryo proper. Expressed at 4.0 dpc in uterus
+In the developing hippocampus, expression is high at P8, then decreased along with hippocampal development
+Expressed in the node during gastrulation. Expression is first detected in primitive streak-stage embryos at about the time of mesoderm formation. It then becomes highly localized in the node at the anterior of the primitive streak
+Highly expressed in eggs, then decreases
+Expression of alpha-dystrobrevin is up-regulated during differentiation, with isoforms 2, 5 and 6 expressed earliest and isoform 3 and 4 expressed later
+At stage 8 (4-6 somites) expressed in two prominent regions, the notochord and the one posterior to Hensen node. At stage 14 (20 somites) expressed in the lateral border of the segmental plate. As the somite stage proceeds, detected in the lateral and medial portion of a young and old somite respectively and is also localized in the notochord and the roof plate of the neural tube
+Expressed at similar levels throughout all flowering stages but accumulates in senescing flowers
+At early leaf developmental stages, expressed in a spot at the distal end of the organ. As leaf development progresses, present in procambium and differentiating vascular tissues
+Expressed in embryos from 8 days of gestation onward
+Expressed both maternally and zygotically. Maternal expression is uniform at the blastoderm stage. Zygotic expression becomes predominant at the extended band stage. After germ band retraction, expression is restricted to the ventral nerve chord and the brain
+In embryos, expressed from the late comma stage
+Uniform expression throughout development and in adults (at protein level) (PubMed:16439308). Isoform A: Expressed in larvae (PubMed:15035436). Isoform B: Lower levels of expression in larvae compared to isoform A (PubMed:15035436)
+Expressed at low levels at day 3 after birth but increased gradually with age from this time
+Expression increases at the orange (Or) and red (R) fruit stages. Expression is increased with ethylene at mature green (MG) stage, but only after six days post-treatment. Expression is increased three days post-treatment with plant hormone abscisic acid (ABA) at the Or stage, but not at the MG or breaker (Br) stages. No change in expression level up to six days post-treatment with ABA at the MG fruit stage (PubMed:26959229). Expressed during floral development (PubMed:21735233, PubMed:28167023, PubMed:27645097). During bud-anthesis stages flowers exhibit dynamic expression pattern in sepal, stamen, ovary and petal (PubMed:28167023). Expressed during ovary development with the highest expression on the third day after the flower fully opened (PubMed:21735233). During seed germination, expressed in the cotyledon. Expressed strongly in the pollen grain. Expressed in the developing fruits, in which mainly expressed in the vascular tissues and seeds. During growth, strongly expressed in leaf, where mainly expressed in the trichome and in the root tip and lateral root formation sites. Expressed in the vascular tissue and the epicycle of the root. Also expressed in branch (PubMed:27645097)
+Expressed at relatively constant levels up to the end of the embryonic stage (72 hours), with a moderate decrease between the 12 and 24 hours stages marked by the formation of somites and organ rudiments
+Expressed in the S and G2 phases
+First detectable at stage 17 during the initiation of limb bud formation. From that point onwards, the expression pattern exactly matches the location of the zone of polarizing activity (ZPA)
+It is present during all stages of starvation-induced multicellular development. It is 5.7-, 6.5- and 10.9-fold higher at 8, 16 and 24 h, respectively after starvation
+Expression decreases until onset of zygotic transcription before increasing again at later stages. Is expressed in neural crest cells, in particular in a subpopulation that give raise to the adrenal medulla
+Not expressed until 19 dpc
+Detected in the eye at gestational days 53-54 and at gestational week 10
+Expression starts 30 hours post-fertilization (hpf) and is restricted to the anterior and posterior lateral line ganglia and the otic sensory neurons. At 48 hpf expression becomes also evident in the trigeminal ganglia. At 96 hpf expressed throughout most of the central nervous system. Excluded from the dorsal forebrain except for the habenula nuclei
+The short isoform was detected in 7 weeks old mice but not in developing mice (19.5 dpc embryos or in 2, 8, and 21 days old animals)
+In roots, detected in the more basal region of the elongation zone and the differentiation zone, mainly restricted to columella, transition zone and root stem cell niche
+Expressed in the retina 4 days post-fertilization (hpf)
+In brain first detected at 6 dpc and persisted until 14 dpc. On 10 dpc brain, expressed in the dorsal region of the telencephalic hemispheres and cells located in the ventral diencephalon. On 14 dpc head, expressed in the meninges of the spinal cord. Expressed in the developing optic nerve and at the optic nerve/pecten junction
+In roots, restricted to the endodermis/pericycle above the middle of the differentiation zone and the regions where new lateral roots are emerging
+Detected in the hypocotyl, with the highest expression in the rapidly expanding segment of the hypocotyl and lower expression in older, less rapidly expanding parts of the hypocotyl
+Throughout the larval period
+Expressed in the developing eye at 14 dpc
+All (z+), (z-), (y+) and (y-) isoforms present throughout muscle fiber basal laminae in neonatal animals
+Expressed in fetal brain, lung, liver and kidney
+Expressed during the course of nervous system (CNS) development, with expression in differentiating primary neurons at stage 15, in the neural tube and olfactory placodes at stage 19, and in the developing eye and other anterior neural structures by stage 27. Expressed in the optic vesicle at stage 25, and increases in the eye at later stages (PubMed:29518376)
+Expressed during embryonic development (at protein level) (PubMed:12537569). Expressed both maternally and zygotically (PubMed:10921908)
+Expressed in ciliated structures in the embryos namely, Kupffer's vesicle, pronephric ducts, otic placodes and ventral spinal cord (at protein level) (PubMed:27687975). Also expressed in the ventral midline of the midbrain primordium (at protein level) (PubMed:27687975)
+Expressed in the photoreceptor cells of the retina at 16 dpc and in pineal gland at 21 dpc. Expressed at P5 in photoreceptor cells and P6 in the pineal gland at protein level
+Expression begins near the time of neuronal cell type specification. First apparent at 10.5 dpc in the nervous system, with high levels in the telencephalon and less in the diencephalon, mesencephalon and spinal cord. This pattern of expression persists and becomes more defined at 12.5 dpc and later stages. Detected in dorsal root ganglia, but not in neural crest derivatives that give rise to non-neuronal tissues, including great vessels. Expressed in postmitotic cells in the CNS, but not in actively proliferating precursor cells. At protein level, first detected at 12.5 dpc in nervous tissues. In the developing forebrain, cerebellar primordium and spinal cord, strictly expressed in postmitotic neurons
+Expressed during early-embryogenesis in the embryo proper and the suspensor up to late heart stage. Expression is not detected in the embryo during maturation
+Expressed in vegetative and early developing cells and then begin to disappear as the cells aggregate
+Detected at high levels at the tube tip during early pollen germination. In germinated pollen tubes it is localized in a punctate pattern throughout the cytoplasm but most prominently at the tip region
+Initially transcribed in the cardiac crescent prior to formation of the primordial heart tube. Following formation of the primitive heart, present in both endocardium and myocardium as well as in other lateral plate derivatives. Also transcribed in the primitive embryonic gut and in late stage embryos is sequentially up-regulated in distinct segments of gastrointestinal epithelia as they undergo terminal differentiation
+Expressed only in the adult stage
+Developmentally regulated in testis. Expression is first detected at 17 days after birth and is later up-regulated up to adulthood amd maintained thereafter
+Highly expressed in roots in the early stage of seedlings growth
+At the vegetative stage, strongly expressed in the shoot meristem, leaf primordia and juvenile leaves. At the reproductive stage, localized in the young developing flowers. Expressed in inflorescence meristem and is up-regulated during flower initiation and formation of flower organs. Also found in cells that differentiate into pedicels
+In adult testis, expressed in differentiating spermatagonia and preleptotene spermatocytes, but not during other stages of spermatogenesis (at protein level). Detected in testis from 13.5 days post coitum (dpc) onwards. Detected in ovary from 13.5 dpc, but levels gradually decline and are undetectable by 3 days post partum (dpp)
+Shorter forms or low molecular weight tau (lMW-tau) are generally expressed at early development stages and longer forms or high molecular weight tau (hMW-tau) in the adult brain
+In developing seeds, accumulates specifically at different stages. At globular stage, present in micropylar end of seed coat, in the endosperm and in the embryo suspensor. At the heart stage, confined to the micropylar end of seed coat. From the linear mature cotyledon stage until mature seed, present in the micropylar end of seed coat as well as in the endosperm
+Abundant during the third larval stage
+Expression starts at the mid-gastrula stage in the dorsal midline. Expressed in the axial mesoderm at this stage. At neurula stages, expression is detected both in the axial mesoderm (notochord and prechordal mesoderm) and in the ventral central nervous system (floor plate and ventral forebrain). At tailbud stages, expression is diminished in the notochord and remains in the ventral central nervous system (CNS). During and after tailbud stages, other regions shows detectable levels of expression. The epiphyseal placode has a strong expression. Additional expression is found in dorsal parts of the CNS, especially in the anterior spinal cord and hindbrain as well as in the tailbud mesoderm. At the larval stage, expression is also found in the forming heart. Induced in mesoderm and in ectoderm by nodal-related genes
+Expressed in the sepals and carpels of young flower buds. At stage 10 of flower development, expression in the carpels becomes restricted to the style. Also expressed in anthers and filaments. At stage 13, expressed in the region at the top of the pedicel, including the abscission zone. Expressed in developing siliques
+Expression is detected from embryonic day 7 and continues throughout development and into adulthood
+Expressed in daughter cells
+First detected in a subpopulation of cells lateral to the primitive streak corresponding with the area of prospective segmental plate mesoderm and somites (PubMed:9187085, PubMed:9281340). Later in development, it is expressed throughout the segmental plate and newly formed somites and is restricted to the paraxial mesoderm (PubMed:9187085, PubMed:9281340). After somite formation, its expression decline in the lateral region of the somite (PubMed:9187085, PubMed:9281340). Later it is expressed at highest levels at the cranial and caudal edges of the more mature somites (PubMed:9187085, PubMed:9281340). As the dermomyotome and sclerotome formed, expression disappeared from the ventral regions of the somite, but persisted in the dermomyotome (PubMed:9187085, PubMed:9281340). When the dermomyotome developed further into the dermatome and myotome, expression is detected in both compartments, although more prominently in the dermatome (PubMed:9187085, PubMed:9281340). Expression was also detected in migrating precursors of tongue muscle and in the limb buds (PubMed:9187085, PubMed:9281340)
+During maturation of dendritic cells, expression is down-regulated and stabilizes MHC class II proteins accumulate at the plasma membrane
+Expression is highest during the early stages of postnatal development, at later stages levels greatly decrease
+During embryogenesis, first observed at low levels in the embryo protoderm starting at the late globular stage (PubMed:25564655). In primary and lateral roots, observed in the epidermis, the outer layer of columella cells and lateral root cap (PubMed:25564655). Restricted to the epidermal cell layer during floral organ formation (PubMed:23590515). Also present in flower meristems, shoot apical mersitems (SAM) and leaf primordia (PubMed:25564655)
+Already detected at embryonic day 8.5. Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5 dpc-16.5 dpc
+Present in aerial but not submerged hyphae, persists as hyphae differentitate and form spores; present at the outer surface of aerial hyphae and spores (at protein level)
+Up-regulated during neutrophil differentiation (PubMed:16376304)
+Expression starts at the L1 larval stage in glial cells associated with amphid, phasmid, labial and posterior deirid sensory neurons and continues throughout adulthood. Expressed in vulva at the L4 larval stage and in adults
+Produced abundantly in spheroplasts, not detected in intact cells
+First expressed in early to mid-globular-stage embryos. In late globular stage, detected as a stripe running medially across the top of the embryo. In heart stage embryo, expression is restricted to a stripe between the cotyledon primordia, but confined to hypodermal cells. In the bending-cotyledon stage, localized in a region surrounding the SAM, that correspond to the boundary region of cotyledon margins (BCM) and the boundaries between SAM and cotyledons, including protoderm cells. Observed in the margins of leaf primordia, and later restricted to the leaf sinus region, with a diminution in outgrowing teeth. Restricted to the proximal part of mature leaves. Expressed at the boundaries between the inflorescence meristem (IM) and flower primordia. Once the flower starts to grow out and the internode begin to elongates, restricted to the axils of the floral pedicels through several nodes. Detected within floral primordia, between sepal primordia and the floral meristem. Also present at the boundaries of individual sepal primordia, as well as in the region surrounding each petal and stamen primordium. Later detected transiently at the boundaries between locules of each theca in anthers. Expression at the inner part of presumtive septal regions that raises to include presumptive placenta, at the tips of septal primordia, as septum grow. Localized in the fused region of the septum. Found at the boundaries of ovule primordia, and later at the boundary between the nucellus and the chalaza
+In seedlings and in late stages of fruit ripening
+Highly expressed in neonatal tissues. In the adult, reaches a maximal level around parturition
+Detected in cytoplasm of somite cells at the beginning of fourth week of development. Detected in cytoplasm of limb bud cell between the sixth and eighth week of development
+Expression is strongly increased in hypothalamus between postnatal days 12 and 20, to reach high constant values in adult
+Present at synaptic connections both in the CNS and in neuromuscular junctions in the mature embryo (20-22h) and throughout larval development. In the third instar larva, it is expressed in all synaptic bouton types, including I, II and III boutons
+Expressed at high levels in all stages of embryonic development analyzed (7 days to 17 days). First detected around 10.5 dpc in the developing ventrolateral telencephalon. Is found at moderate levels throughout the ventricle zone (VZ) of the entire telencephalon with the exception of the ventro- and dorso-medial regions. The highest expression is detected in the subventricular zone (SVZ) of the lateral ganglionic eminence (LGE) and developing striatum. By 16.5 dpc, also found in the cortical plate. Also expressed at high levels in the caudal ganglionic eminence (CGE) and amygdala. Expression in the telencephalon remains unchanged at birth and into adulthood
+Expressed in developing anthers during meiosis and young microspore stages
+The DM-20 protein is the major proteolipid component in fetal brain. With the appearance of white matter (27-30 weeks of gestation), levels of DM-20 begin to increase significantly and then, dramatically, from weeks 31-40 reaching maximum levels in adulthood. In contrast, PLP is not detected until weeks 31-35 after which levels greatly increase and it becomes the major proteolipid in adults
+First detected at low levels at approximately postnatal day 7. Subsequently, expression increases rapidly during the first month after birth
+Expressed in distal tip cells of the growing gonad arms from L3 to the young adult stage (at protein level)
+Expressed at high levels in developing forebrain. This expression decreases slightly in embryonic and early postnatal days
+Expressed from 8.25 dpc and confined to mesenchymal cells throughout the embryo development. Expression is seen at several sites including craniofacial region, first branchial arch and anterior aspect of the limb bud
+Expressed in zygotes and blastocysts (at protein level). Expressed in gonads at 12.5 and 14.5 dpc (at protein level). Expressed in germ cells at 16.5 dpc (at protein level). Expressed in brain at 10.5 dpc and declining towards birth (at protein level). Expressed during fetal development at 7, 9.5, 10.5, 12.5, 14.5 and 17.5 dpc and declining towards birth
+Found at 48 dpc in the anterior cranial base with detection concentrated in the sphenoid precursor. Expression is also detected in the pituitary gland
+Both short and long isoforms are found in a 17 days old embryo, whereas the short isoform is the only isoform present in the newborn muscle
+Expressed in the retinal layer of the optic vesicle, and weakly expressed in the retinal pigment epithelium at 12.5 dpc
+At 7.5 dpc specifically expressed in the ventral node
+Expressed from the late embryo stage onwards, with high expression at the late L4 stage of larval development
+First observed in the floral apical meristem (FAP). In flowers, observed in petals and anthers, particularly in anther filaments
+The earliest expression could be detected in a 12.5 dpc embryo in the cartilage anlage of the developing bones. At 14.5 dpc the primordial skeleton shows a strong expression. At birth present in the developing occipital bones, bones of the nasal cavity, manubrium and corpus of sternum as well as in the cartilage plates of trachea. At no stage of development detected in extraskeletal tissues
+In the developing cerebellum, maximal levels occur at postnatal day 7 and correlate with the onset of neuronal differentiation
+Expressed in cells in the growth phase and throughout the developmental phases
+Widely expressed in all stages from the embryo to the adult in a complex and dynamic pattern (PubMed:10625546). In L1 and L2 stage larvae, expressed in intestinal cells, lateral hypodermal cells, the anal sphincter muscle, phasmid sheath cells, neurons in the lateral ganglia, and the excretory duct cell (PubMed:10625546)
+Levels increase in the embryos 1.5-2 hours after fertilization and reach a maximum at 6 hours post-fertilization, then decrease to a very low level in early gastrulating embryos (12 hours post-fertilization)
+Low expression levels observed at 12 dpc in neural tube and brain. On days 15.5 and 16.5, expression levels increased and became localized specifically to the forebrain, with highest levels found in the laminar region of the forebrain cortex. Also expressed in the mitral region of the olfactory bulb
+Accumulates during tracheary element differentiation
+Expressed in the utricular hair bundles at 14.5 dpc (at protein level) (PubMed:16464467). At P1 expressed in cochlear hair bundles of the sensory cells extending to the apical surface of the greater epithelial ridge and in the vestibule where it is restricted to hair bundles (at protein level) (PubMed:16464467)
+Overexpressed at day 11 in the embryo
+Expressed in the brain at 15 and 22 weeks of gestation, with a pattern of strong cortical, basal ganglia, thalamic and cerebellar expression. Highly expressed in the head and tail of nucleus caudatus and putamen. Restricted expression within the globus pallidus, with high levels in the pars interna, which provides the principal source of output from the basal ganglia to the nucleus centrum medianum thalami (CM) and the major motor relay nuclei of the thalamus. In the thalamus, present in the CM and nucleus medialis dorsalis thalami. Lower levels are observed in the nuclei anterior thalami, dorsal and ventral, and the nucleus parafascicularis thalami. Expressed in the ventrobasal complex comprising the nucleus ventralis posterior lateralis/medialis. The ventral tier of the thalamus exhibits strong expression, including nuclei ventralis anterior, lateralis and posterior lateralis pars oralis. Also expressed in the nucleus subthalamicus bilaterally and in the nucleus ruber
+Expressed at higher levels in cells growing as hyphae than in those growing as budding yeasts
+Expressed in eggs and larvae, but not in adults
+Expressed in the embryonic heart. Expressed from embryo day 9.5 to birth. At day 12.5, expressed in the midbrain, hindbrain, spinal cord, sensory ganglia, epidermis, nephric system and limbs. At mid-embryogenesis, isoform 3 is the most abundant form in the nervous system and total embryo, but the least abundant form in the epidermis. In adults, AP-2A is expressed in the eye, skin, kidney, prostate, thymus, skeletal muscle and very weakly, in the brain. Highest expression found in skin and eye
+Expressed throughout embryonic development with highest levels from 7-11 dpc. Also expressed in the adult
+Weakly expressed at 7 dpc and remains constant from 11 dpc to 17 dpc
+Localizes to germline and somatic blastomeres (at protein level)
+Expression is first detected at the animal pole at stage 9. During neurula stages it is found both in the extreme anterior and posterior part of the dorsal body axis. In tailbud stages the expression is further shifted to both the tail and head areas and gradually restricted to distinct tissues: forebrain, inner layer of epidermis of the head area, stomodeal-hypophyseal anlage, frontal gland, ear vesicle, branchial arches, the front tip of neural tube and proctodeum
+Mostly expressed in actively proliferating tissues (PubMed:16460730). Specifically expressed in degenerating megaspores of normal ovules and in enlarged megaspore mother cells and embryo sacs of apomeiotic ovules. Also detected in microspore tetrads at the beginning of pollen development as well as in tapetum cells of anthers undergoing programmed cell death (PCD) to allow pollen dispersal at maturity (PubMed:16240174)
+Detected throughout the inflorescence at a higher level in the inflorescence meristem (IM) than in the young flower. Very strongly expressed in the valve, septum, and developing seed. Also present in pollen grains
+Expressed in developing embryos in intestinal cells (at protein level)
+At 13.5 dpc, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, cerebral cortex, cerebellum, hippocampus and olfactory bulb
+Expressed in proliferating chondrocytes in the chondroepiphysis during musculoskeletal development
+Expressed during embryogenesis. At 14 dpc, not detected in the brain or spinal cord. A striking expression seen in the nerve roots but not in the developing neurons of the dorsal root ganglia. A significant expression also seen around the superior mesentric artery
+Expression is dramatically down-regulated after embryonic day 7 in the optic tectum, and correlates with the onset of apoptosis in this area
+First detected at 11.5 dpc and expressed continually throughout development, its expression level fluctuated during gestation
+Expressed at low levels until 13 dpc and the expression rises transiently between 13 dpc and 16 dpc
+At 12.5 dpc, weak expression in the developing lung and hindbrain, high expression in the tongue mesenchyme (PubMed:27697108). At 14.5 dpc, expressed in the trigeminal ganglion, oral epithelium and hindbrain (PubMed:27697108). Also detected in lung, kidney and somites (PubMed:27697108)
+In the embryo is expressed in the developing hindbrain and is accumulated in rhombomere boundary regions and in the rhombomere 2, 4 and 6
+Expressed in sporozoites (mosquito salivary gland stage) (at protein level)
+Found in the forebrain, midbrain, hindbrain, pharyngeal arch, somites, and forelimb buds at day 9.5 dpc. At day 10.5 dpc, strongly expressed in dorsal neural tube, developing pharyngeal arches and frontonasal region with low expression in the ectoderm overlying the developing optic vesicle, expression can be observed in the optic stalk. At 11.5 dpc it is localized to the closure site of the optic cup. In developing limbs between days 10.5 dpc and 11.5 dpc, it is found in both dorsal and ventral regions, but expression is predominant dorsal in hindlimb bud and not detected in the most anterior, posterior, and distal parts of limb buds. Expression coinciding with chondrogenic condensation can be observed at 12.5 dpc. Expression is restricted to future synovial joint regions at day 13.5 dpc
+First expressed in splanchnic mesoderm of stage 4 embryos. At stage 6, strongly expressed along the neural fold in a region corresponding to the future neural crest. Expression in the neural fold continues during closure of the neural tube but diminishes after neural crest cells have left the neural tube
+Detected in somites and limb buds at 9.5 and 13 dpc, in embryonic limb muscle and tongue (PubMed:23626854, PubMed:23818578). Detected in tongue and diaphragm at 14.5 dpc (PubMed:23818578)
+Within the developing nervous system, the expression is very dynamic. At 16.5 dpc expressed predominantly in the primordial cortex of the telencephalon. Besides the midbrain it is also expressed in the hypothalamus, and the neurohypophysis. Non neuronal expression domains include the ectoderm of the branchial arches, the ectoderm and mesenchyme surrounding the dorsal root ganglia, the intervertebral disks, maxillary and mandibulary mesenchymal elements as well as the nasal mesenchyme and ectoderm. In myogenic progenitor cells, expressed at least as early as 11.5 dpc until adulthood (PubMed:27446912)
+At early neurula stages, exclusively activated in the presumptive ventral telencephalon. Since midneurula stages also found in the medial aspect of the eye field. At tailbud and tadpole stages, expression seen in the optic stalk, optic nerve, optic disk, ventral retina, ventral telencephalon and diencephalon. Finally during metamorphosis expression is maintained in the optic chiasm, ventral hypothalamus and hypophysis
+Expressed at similar levels in fetal and adult tissues
+Expressed in the somatic lineage from the 4-cell to 60-cell stage
+Only present in alpha-cells and in a/alpha diploid cells
+Predominantly expressed in starved cells just before the putative shift point
+Expression increases in the panicle from 7 days before flowering to flowering stage, to become undetectable 7 days after flowering
+In the vegetative phase, expressed in shoot meristems and leaf primordia. In the reproductive phase, present in the meristems of primary and secondary branches at primordial and elongating stages, but later transiently down-regulated from the meristems, when the meristem identity change from inflorescence to spikelet. Subsequent expression recovery when spikelets are differentiated, with an accumulation in floral meristems and in primordia of all floral organs, including lodicules, stamens, carpels and ovules
+Expressed at the time when separation of neural and epidermal precursors cells occurs. Mesectodermal expression appears shortly before the onset of gastrulation
+Expressed zygotically from stage 10 (early gastrula) to all subsequent embryonic stages
+Expression is first seen in the 12-13-cell embryo and is last observed in the 16-cell embryo before division
+Detected in embryonic testis at embryonic days 14.5 dpc and peaks at 16.5 dpc
+Expressed during seed development, with a pic at mid-maturation
+Expressed constitutively during plant development
+Expressed during rhizobium-induced nodule formation. In 4-day old nodules it is found in all the cells of the center of the nodule primordium and also occurs in the root cortical cells containing the infection thread. At day 5, expression is seen in the complete central tissue and at day 20, expressed in the complete prefixation zone II and is present at a similar level throughout the zone. In the distal part of the prefixation zone II it is probably expressed in all cells, whereas in the proximal part, found only in the infected cells. Expression decreases at the transition of prefixation zone II into interzone II-III
+Isoform 1 expression was relatively low early in development and increased postnatally, reaching a peak at P14. Isoform 3 is detected at low levels prior to P9, whereupon its expression increases, with the highest levels in the adult
+Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc
+Low at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak values between day 21 and 56
+Highly expressed during fetal thymus development and decreases after day 16
+Expressed throughout development. Expression is weak during embryonic stages and peaks during larval and pupal stages
+Expressed in the left-right organiser at embryonic day 8.0 dpc and at 17.5 dpc, expressed in the airway epithelia and brain ependymal tissues
+First detected in the developing heart tube at 8.0 dpc and then in cardiac, skeletal and smooth muscle during early stages of development. Highly expressed in differentiating gut epithelial cells
+At 12.5 dpc, expressed ubiquitously in the developing central nervous system. This pattern persists at 14.5 dpc and 16.5 dpc, with expression levels varying
+Appears on embryonic day 16.5 and is expressed thereafter
+Expressed at all developmental stages, with high expression during embryogenesis
+Expressed early in embryonic development (11 dpc) in distinct regions of the neuroectoderm and mesoderm. Expression became more extensive at later stages
+Expression is positively regulated upon differentiation and is not related to the cell cycle
+Strongly expressed during the maturation phase in seeds and pollen grains, both desiccation-tolerant tissues
+Expressed only in early stages of flower development
+Highest expression in embryos
+Expressed in shoot apices and leaves from very early stages, and later in inflorescence and floral primordia as well
+Expressed at low levels during early embryogenesis and at highest levels between NF19 and NF28. Expressed in the involuting mesoderm of the gastrula. Expressed in non-neural ectoderm of the early neurula, and excluded from neural plate
+Expressed maternally and is widely distributed in the early embryo (PubMed:8562427). Expressed in the posterior ventral and lateral mesodermal, and ectodermal cells during gastrulation (PubMed:25371059)
+First detected after 3 weeks postnatal development
+Expressed from 6.5 dpc. From 12.5 to 15.5 dpc, expressed in the nervous system and developing muscles
+Expressed in embryo at 7 dpc
+Expressed throughout development in larvae and pupae. Expressed at embryonic stage 14-17 in a small constriction of the gut, in the full complement of cardial cells and in a paired anterior structure, possibly belonging to the antenno-maxillary complex
+Detected in seed coats in the inner layer of the outer integument at the beginning of the desiccation stage. Also expressed at the chalazal region as desiccation proceeds
+Ubiquitously expressed during embryogenesis, starting at 8 dpc
+Expressed both maternally and zygotically. Expressed ubiquitously during early embryogenesis, but becomes localized to the tail region during segmentation. During early larval development, expressed in discrete areas including the pronephric region, retina and cerebellum
+Transiently expressed in spermiogenesis, being mostly concentrated in the periaxonemal compartment of the tail of the elongating spermatid, where it transiently associates with the longitudinal column of the FS. In the very last steps (steps 17-19), when periaxonemal expression disappears, it is still weakly present in the shrinking cytoplasmic lobe (at protein level)
+Expressed in the anterior presomitic mesoderm (PSM) and somites at 9.5 dpc. Expressed in endothelial and smooth muscle cells of blood vessels at 9.5 dpc (PubMed:11562355). Expressed in growth plate chondrocytes and perichondrial cells at 13.5 dpc (at protein level) (PubMed:25808752). Expressed in non-notochordal mesoderm surrounding the node and notochord at 7.5 dpc (PubMed:9106663). Expressed in anterior presomitic mesoderm adjacent to somites, in the somites, and in the cephalic mesoderm at 8.5 and 9.5 dpc (PubMed:9106663). Detected weakly in yolk sac at 9.5 dpc (PubMed:11562355). Expressed in presumptive intermediate mesoderm, as well as in the presomitic mesoderm and somites at 8.5 and 9.5 dpc (PubMed:10704385). Expressed in the metanephric mesenchyme of the kidney at 10.5 and 12.5 dpc (PubMed:10704385). Expressed during the developing cardiovascular system (PubMed:10479458). Expressed in the branchial arches and mesenchymal cells surrounding the eye at 10.5 dpc (PubMed:9106663). Expressed in nasal processes, corneal mesenchyme cells, branchial arches, blood vessels and endocardium at 11.5 dpc (PubMed:9106663, PubMed:10395790). Expressed in cells located in the presumptive anterior segment that are fated to contribute to the corneal endothelium or stroma, as well as within cells located at the periphery of the optic cup at 11.5 dpc (PubMed:16449236). Expressed in periocular mesenchyme cells at 11.5, 12.5 and 16.5 dpc (PubMed:10395790, PubMed:16449236). Expressed in developing limb buds at 12.5 dpc (PubMed:25808752). Expressed in chondrocytes at 15 dpc (PubMed:25808752). Expressed in the trabecular meshwork cells, the sclera, the conjunctival epithelium and the corneal epithelium at 16.5 dpc (PubMed:10395790). Strongly expressed in adipo-osteogenic progenitor cells (CXCL12-abundant reticular (CAR) cells) at 16.5 dpc and at birth (PubMed:24590069)
+Expressed faintly from 18 dpc in the kidney. Expression increases in the kidney after 4 days of age
+Expressed in embryos and larvae
+Expressed maximally in 7-day-old brain and expression decreases progressively until adulthood (35-day-old brain)
+Expressed during second and third larval instars, but not in the adult
+Low levels of expression in olfactory bulb, caudate putamen, cerebral cortex, hippocampus, thalamus, midbrain and cerebellum during early postnatal development. In later stages, exclusively expressed in cerebellum culminating at P14 of postnatal development
+Expressed weakly in L1 animals and strongly throughout the remainder of larval development (PubMed:9764821). Expressed in posterior intestinal cells, neurons, hypodermal cells and body wall muscles (PubMed:9764821)
+Expressed in presomitic mesoderm and developing somites at 8.5 dpc, accumulating in the epaxial domain at 9.5 dpc in the immature caudal somites. At 10.5 dpc expressed in the dermomyotome of somites. By 11.5 dpc, only detectable in caudal somites. In mature somites, expression is confined to the dermomyotome of the somite where Pax3 is also expressed and in the epaxial domain of the most immature caudal somites. At this stage, the most mature anterior somites are beginning to lose the expression at the epaxial and hypaxial extremities of the dermomyotome. At 14.5 dpc expressed in testis, heart and brain. Expression is also detected in proximal forelimb buds and branchial arches of the developing embryo
+Expressed both maternally and zygotically. Maternal expression levels are low and become further reduced after fertilization. Zygotic expression begins at the mid-blastula transition and peaks during the gastrula/neurula stages. A lower level of expression is then maintained during tailbud and later stages
+Expression increases rapidly during seed germination to reach a peak at 2-3 days after imbibition (DAI) and then declines to basal levels at 5 DAI
+Up-regulated during dendritic cell maturation
+Expression is first apparent in bean-stage embryos, peaks in late embryogenesis, reduces in L1 larvae and is negligible in later larval stages and adults (PubMed:19344940). In the embryo, expressed in the excretory cell and, during dendrite formation, in the non-neuronal cells surrounding the sensory neurons, including hypodermal cells (PubMed:19344940). Expressed in pharyngeal cells throughout the larval stages (PubMed:30409788). Expression in the seam cells and glia socket cells of the anterior and posterior deirid neurons begins at the L2 pre-dauer stage and persists throughout the dauer phase (PubMed:30409788). During the dauer phase expressed along the length of the animal above seam cells, alternating between alae under the outer ridges and below the lateral ridge (PubMed:30409788)
+Isoform IQCJ-SCHIP1-1 and isoform IQCJ-SCHIP1-2 are expressed in fetal brain, kidney, spleen and skeletal muscle. Isoform IQCJ-SCHIP1-2 is also detected in fetal heart and lung
+Expressed in fetal tissues with higher expression in fetal heart and kidney
+Isoform 3 is first detected in testis 22 days after birth, coinciding with the first wave of round spermatid development. It is also detected on 30 and 60 days after birth
+Expressed at high levels in germinal vesicle (GV) stage oocytes and at lower levels in MII-stage oocytes and zygotes. Expression then decreases from 4-cell stage to blastula
+The concentration in intestinal tissues undergoes an abrupt increase during the animal's transition from suckling to weaning
+First detected in the embryo after 4.3 hours
+Is probably activated at the time immediately preceding spore cortex formation (stage IV)
+Present in large cell variant (LCV) stage and small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs
+In erythrocytes, expression levels decrease throughout differentiation (PubMed:27641616). Not expressed in mature erythrocytes (PubMed:27641616)
+Detected at 18 dpc, and then decreases thereafter to a very low level at the day of birth. Detected again at 48 hours postpartum, and then increases at 96 hours until 6 days after birth
+Expressed in proliferative zones during development and in the adult in areas of neuronal plasticity. At 12 dpc, expression is localized in the cortex, cerebellum, pons, medulla and spinal cord. From 18 dpc to adulthood, high levels of expression are found in the pyramidal cells of hippocampal layers CA1-CA4, and in the granular cells of the dentate gyrus. At postnatal day 7, expression is high in the visual cortex and in the subependymal region extending from the anterior lateral ventricle into the olfactory bulb
+Expressed post-meiotically
+At 10 dpc, confined to the developing heart and the somites at the tips of the myotomal cells near the intermyotomal septum. At 14 to 15 dpc, accumulates near the myotendinous junctions, the site of sarcomere assembly in growing myotubes. Present in negligible amounts in proliferating myoblasts, induced during differentiation
+First detected at 12.5 dpc in newly generated neurons adjacent to the ventricular zone of the dorsal spinal cord. Later expressed in lateral region of the dorsal spinal cord and dorsal root ganglia at 13.5 dpc with increased levels at 15.5 dpc
+At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 9. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 7/somite 8 boundary
+Expressed during seed maturation (PubMed:21718052). Expressed during embryonic development including the water, gel, dough and mature nut stages in the nut cavity tissues including the contents of the central vacuole, endosperm, embryo, placenta, seed coat, ovary packing tissue, developing fruit and cotyledon lobes. Expression increases during the transition from water to gel stage, levels off or decreases slightly from the gel to dough stage and increases again from the dough to mature stage (PubMed:28121438)
+Expressed at the promastigote stage
+NoT detected in the uteri from days 1-3 of pregnancy. On day 4 of pregnancy, localizes in the luminal and glandular epithelium as well as in the uterine stromal cells. On day 5, a high level is observed in the subluminal stroma surrounding the implanting blastocyst, while there is no expression at the inter-implantation sites. From day 6-8 of pregnancy, strongly expressed in the decidua. Expression is gradually increased as the progression of pregnancy and reached a maximum on day 8. Elevated expression is observed at implantation sites from days 5-8 of pregnancy
+Expressed in both pre- and post-implantation embryos
+Detected in globular-, heart-, and torpedo-stage embryos, in the outer integuments of ovules and in the funiculi. Also expressed in the peripheral zone of the shoot apical meristem (SAM) corresponding to the central zone. In elongating tissues, restricted at the periphery of the vascular bundle. In shoot and inflorescence apices, mostly present in the L2 layer, and, at lower levels, in the L1 layer, but absent of the L3 layer. In young leaf primordia, localized in the basal part of the dorsal side. In older leaf primordia, detected in vascular bundles and in the mesophyll between the vascular bundles. In expanding leaves, confined to stomatal guard cells, and individual palisade and spongy mesophyll parenchyma cells. In general, present around the vascular bundles. Expressed in young flower organs but not in mature sepals and petals. Gradient accumulation in the stamens and carpels, with the highest activity at the tip of the organs. Present in the meristematic and elongation zones of the primary root and in the vascular bundle of the differentiation zone
+Broadly expressed in tissues at the L1 larval stage (PubMed:29702639). In the male germline, first expressed in primary spermatocytes at the L4 larval stage and expression increases as spermatocyte differentiation progresses (PubMed:29702639)
+Induced at programmed cell death
+Isoform A is expressed only in mid-pupal stages, while isoform B is maximally expressed in newly formed prepupae and immediately following isoform A in mid-pupae
+Maximal expression at days 14 and 16 of pregnancy
+Expressed at low level in the proximal mitotic region and transition zone of germline cells and at the pachytene stage of meiotic prophase I
+Present in thymocytes from 16.5 dpc (at protein level)
+Expressed in the 32-cell stage ABar blastomere and onwards into late embryogenesis (PubMed:15620652, PubMed:24401370). In late embryogenesis, enriched at the leading edges of postmitotic epidermal cells during ventral enclosure (PubMed:15620652). Asymmetrically expressed during the larval stages of development in cells of the gonad, vulva, tail, nervous system and hypodermis (PubMed:15620652). Expressed predominantly in QR neuroblast descendants and to a lesser extent in QL neuroblast descendants during the larval stages of development (PubMed:25373777). Expressed highly in anterior P-cells during larval development (PubMed:23295860). Post-embryonically, it is up-regulated at the transition phase after dorsal-ventral migration of distal tip cells and at the beginning of their anterior-posterior migration (PubMed:26292279)
+Detected in vascular tissue at 36-72 hours post-fertilization, where it localizes to endothelial cells
+During early neurogenesis, expression is ubiquitous. During later stages, expression concentrates at the central nervous system
+Expressed both in proliferating and maturing stages of leaves
+In maturing chondrocytes, expression appears at day 3 and increases thereafter
+Expressed in the pre-gastrula embryo (at protein level)
+Primarily expressed during lateral root formation and embryogenesis
+Expressed throughout early development, with embryonic expression primarily in anterior neural tissues
+Down-regulated during adventitious root formation
+Expressed within the most anterior region of the embryonic body axis during gastrulation and neurulation
+Expression first detected at 10.5 dpc in the maxillary component of the first pharyngeal arch and the lateral aspect of the frontonasal process in the regions that will subsequently fuse to form the primary palate. At 11 - 11.5 dpc, the expression pattern demarcates the region of the medial aspect of the maxillary process within the primitive oral cavity, which will form the palate shelf. By 12.5 dpc, symmetrical expression is seen in the medial edges of the developing palate shelves and this continues until 13.5 dpc when the strongest expression is in the mesenchyme underlying the medial edge epithelia. By the time of palatal shelf fusion at 14.5 dpc the expression is dramatically down-regulated. No expression detected elsewhere in the embryo at any stage examined
+Expressed during nut development. Expressed in gel stage of the seed kernel
+In spermatocytes, shows punctate localization along chromosome axes specifically in early meiotic prophase I cells. Foci start to appear from the leptotene stage, reach their greatest number in the zygotene stage, in the early pachytene stage, the DMC1 foci mostly disappeared from autosomes and became restricted to the sex chromosomes
+Expressed throughout embryogenesis from the blastula sphere stage (4 hours post fertilization)
+First expression in embryonic liver is detected at 17.5 dpc
+Expressed in embryos from 7 days onwards, with highest expression at 15 days
+Expressed throughout development, showing up-regulation between stages L2 and L4
+In mid instar larvae salivary glands levels increase during 86-94 hours of development and represent the predominant isoform during puff stage 1. Levels remain relatively constant in late larvae until the premetamorphic pulse of ecdysone. Transcripts are detected again from puff stages 12-14 and 17-21
+During seedling RGP1 expression was first observed 14 days after germination, reaching a maximum level between 28 and 42 days, and gradually decreased thereafter until 63 days when it attained the same level of expression as in 14-day old seedlings
+Expression is highest in developing brain. Transiently expressed in all 3 germ layers (PubMed:11165493). Detected in midbrain, spinal cord, heart and lung at 15.5 dpc (PubMed:24908487). Coexpressed with NGFR in neurons in the ventral part of the hippocampus CA1 region at 23 and 30 days after birth. The number of neurons that coexpress SORCS2 and NGFR is increased 30 days after birth. SORCS2 and NGFR are no longer coexpressed in hippocampus neurons in 60 day old adults (PubMed:29909994)
+Maternally expressed throughout the early blastoderm. Expressed in the neural plate of the tailbud stage embryo, at 10 hours post-fertilization (hpf). Highly expressed in the developing brain at 28 hpf, and at lower levels in the rest of the embryo
+Induced during normal senescence
+Accumulates in root cells that are adjacent to intra-radical fungal hyphae or in cells that harbor them during arbuscular mycorrhizal (AM) symbiosis, especially in epidermal and cortical cells (PubMed:19220794). Also induced transiently in roots epidermal cells (including root hair cells in nodule vicinity) during symbiosis with Rhizobia bacteria (e.g. Mesorhizobium loti), but not observed in nodules (PubMed:19220794)
+Expressed in all life cycle stages
+Highly expressed during fruit ripening and flower development
+Expressed at both the vegetative and floral stages
+Expressed at 6 of 8 hours of sporulation with maximal transcript accumulation occurring at 8 to 12 hours, a time at which the meiotic events if sporulation have been completed and the deposition of spore wall components is beginning
+Expressed at the same level in vegetative cells and throughout development, with a slight peak at the time when the cells are aggregating
+Expressed in a temporally and spatially highly restricted pattern during mouse palate and tongue development
+Expressed during development; with a peak of expression at 12 hours
+High expression in developing cartilage and during chondrocyte differentiation
+Highly expressed at 14 dpc-16 dpc in the forebrain, in the proliferative ventricular zone of the neocortex and hippocampus, and in the cortical and hippocampal plates. Also observed in the septal area, the ganglionic eminence, and in the dorsal thalamus and hypothalamus. In the hindbrain, expressed in many nuclei in the brain stem and in the cerebellar anlage, external granule cell layer, in Purkinje cells and the deep cerebellar nuclei
+Expression is maximal at stages 24-31, then begins to decline. Expression is low by stage 37 and is absent by stage 39. Does not appear to be expressed in adults
+Expressed in the early embryo, in the germ line and in all somatic nuclei beginning at the pronuclear stage
+Expressed at very low levels during embryonic development. Expression increases during the larva stages and peaks at a moderate level during the late larval, prepupal and pupal stages, before decreasing in the adult
+Expressed in shoot and root vascular tissues (PubMed:28751315). In root cap regions, accumulates in columella cells and lateral root caps (PubMed:28751315). Also observed specialized cell types such as trichomes, guard cells and root hairs (PubMed:28751315)
+Expressed both maternally and zygotically throughout embryo to adult stages
+Expressed at high levels in germinal vesicle stage oocytes at the mRNA level. Expression peaks in 2-cell embryos and decreases thereafter. Hardly detectable in morula stage embryos. This pattern of expression suggests a maternally derived transcript
+Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube
+Transcriptionally activated at the 2-cell stage, peaks at the 4-cell stage and then gradually decreased until the blastocyst stage. The protein is detected from the 4-cell stage until the blastocyst stage. In blastocysts, expressed both by inner cell mass and trophectodermal cells (at protein level). Not detected in post-implentation, neither in fetal, nor adult tissues
+Only expressed after meiosis in testis
+During embryogenesis, first observed at the globular stage and accumulates in forming cotyledons at the heart stage (PubMed:30737509). Expressed in the inner basal edge of endodermal cells in the primary and lateral roots (PubMed:30737509)
+Expressed in sexual stages, but not in asexual stages
+MAV1-induced nephroblastomas express a high level of NOV gene whose transcription is normally arrested in adult kidney
+Expressed in somites, neural tube and brain at 8-8.5 dpc. Expression remains constant from 9.5-12.5 dpc with highest expression levels in the limb buds, branchial arches, crainofacial area, brain and spinal cord
+Isoform 1 expression increases throughout the cell cycle and peaks in G2/M phase. Isoform 2 expression is highest in G1 phase and decreases thereafter
+Specifically expressed in pollen grains when the callose of microspores tetrads undergoes degradation, between early tetrad and late trinucleate stages (at protein level)
+Expressed at the earliest stages and throughout LSM initiation and development. In embryo development, expressed at the heart stage until the 'walking stick' stage in the adaxial portion of the cotyledon primordia, the shoot apical meristem (SAM) and the vascular precursor cells of the hypocotyl and root. In developing flowers, expressed first at stage 1 in the center of L3 layer and then expands to the center of L2 and L1 layers. Expressed in the center of flower meristem through stages 4 and 5. At stage 6, expressed in the adaxial side of the carpel primordia and then on the adaxial carpel face
+Expressed late on the penultimate day of feeding in the fifth larval instar. Highest levels throughout the final day of feeding. Barely detectable by the day of wandering. Expression stops when the metamorphosis begins
+First detected at the 75% epiboly stage where it covers the anterior neural plate. Widely expressed in the presumptive mesencephalon and rhombomeres 1-4 until the 2-3-somite stage, with expression persisting in ngn1-positive clusters. First detected in the olfactory placodes at the 5-somite stage. In the spinal cord, detected in ngn1-positive clusters of primary neuroblasts during the early somite stages. Expression decreases in the spinal cord from the 30-somite stage but persists in the olfactory bulb and regions of the rhombencephalon and brain
+Expressed maternally throughout the embryo and then becomes restricted to a pan-neural expression pattern
+In stage 9.5 dpc-15.5 dpc, widely expressed in the surface ectoderm and later in the germinal layer of the skin, the olfactory and otic placode and their derivatives and the lining of the oral cavity. In stages 14.5 dpc-17.5 expressed in ducts connected to epidermis, and in developing epidermal openings. Highly expressed in the early stages of the developing kidney, in the metanephric mesenchymal aggregates, prefusion skeletal muscle, cardiac myoblasts, and in visceral and vascular smooth muscle
+From 12.5 dpc, expressed in the mesenchyme of the developing middle ear, within areas surrounding the condensing malleus and tympanic ring and on both sides of the external acoustic meatus. At 12.5 dpc, borders and surrounds the future cartilages, but excluded from cartilaginous condensations. Not detected in mesenchymal cells in proximal ureters at 14 dpc
+Expressed in the anterior neuroectoderm at stage 14. Expressed during the formation of the neural tube in rhombomeres (r) 5 and 6, in the derivative neural crest cells and then in the dorsal half of neural tube of r5 and r6 at stage 24. Expressed in the presumptive blood islands at stages 22 and 24. By stage 28 its expression in r5 disappears, but becomes detectable in r4 at stages 29 and 30. Its expression in r6 persists until stages 33 and 34. Expressed through r4 in two bilaterally symmetrical columns of cells in the dorsolateral spinal cord at stage 32. Expressed in developing somites at stages 33 and 34. Expressed in myotomal cells at stage 32. Expressed in the pronephros at stage 28. Expressed in the presumptive lens-forming ectoderm (PLE) at stage 22 and during lens formation. Expressed in the inner (sensorial) layer of PLE, developing lens placode and lens epithelium. Expressed in the anterior part of lens vesicle at stages 32 to 34
+In the salivary glands of mid instar larvae levels increase during puff stage 1 at 86-94 hours of development then remain relatively constant until the premetamorphic pulse of ecdysone in late larvae. Levels diminish dramatically from puff stage 7 onwards. Levels increase in the prepupal period during puff stage 13-14, the level remains stable until stage 21. A decrease in levels at puff stage 7 is also seen in the Malpighian tubules and less dramatically in the fat body and gut. In the wing disk the relatively low level remains unchanged
+Maternally and ubiquitously expressed in fertilized eggs, with highest levels on the presumptive dorsal side of blastula. At gastrula stages, expressed throughout the marginal zone and endoderm
+Start to accumulate during the 16- to 32-cell stage of embryogenesis
+Expressed in the vegetal cortex of the oocyte. Expressed uniformly in the embryo. Expressed in the vegetal pole at 0.08 hour post-fertilization (hpf). Expressed in the lens fiber cells at 24 hpf and in the blastodisc of the zygote at 30 hpf
+During endosperm development, expressed in kernels from 10 to 30 days after pollination (at protein level)
+Accumulates in tissues undergoing dehiscence and abscission
+Expressed at low level from stage 1 to stage 9, when expression levels increase
+Maternally expressed: detected from the 1-cell stage, prior to the onset of zygotic expression. From blastula until gastrula stages, strongly expressed throughout the blastoderm. At 28 hours post-fertilization (hpf), highly expressed in the central nervous system (CNS), whereas a weaker expression is found in the somites. At later stages of development (48 hpf), expression persists in well-defined structures of the CNS, such as the diencephalon, the mesencephalon, the cerebellum and the rhombencephalon, and remains detectable in the somites
+Expressed in Malpighian tubules from the 3rd instar larval stage and expression continues in pupae and adults with highest levels in adults (at protein level)
+Produced throughout adult diapause, and to a minor extent in pupae, but not in eggs, larvae, or post-diapausing adults. Inhibition of DSP expression does not affect the onset or maintenance of diapause, indicating that the expression of DSP accompanies but does not play a direct role in the induction or maintenance of diapause
+Expression is maintained at a relatively constant level during growth and development
+In young seedlings, accumulates in shoot and root apical meristems (SAM and RAM, respectively), leaf primordia, and root stele tissues. In roots, high levels throughout young root primordia that later decrease at the arrest of cell division, and finally increase again when the apical meristem become activated. In young developing leaves, present in guard cells, vascular tissues, trichomes, and trichome support cells to be later expressed uniformly in the lamina. Gradually restricted to the leaf margin and fades out in fully expanded leaves. In roots, detected in apices, stele tissues, and lateral root primordia. In flowers, first observed over the floral bud, and later restricted to vascular tissues in developing floral organs, except for the pistil, where the expression is ubiquitous. In mature flowers, disappears progressively from the pistil, but accumulates in mature pollen and the filaments. Also present in pedicels. In pollinated pistils, highly expressed in ovaries that contain developing embryos. Present throughout embryogenesis, particularly in the lower half of the embryo at the heart-shaped stage and in the radicle RAM region at the cotyledonary stage
+More abundant in amastigotes than promastigotes
+Isoform 2 accumulates in the brush border during enterocyte differentiation and migration along the crypt-villus axis in adults
+Weak expression of isoform 1 is seen throughout testicular development. Isoform 2 and isoform 3 could not be detected until postnatal day 15. Expressed from postnatal day 20, and thereafter increased. Expressed in blastocysts and in embryos from 8.5 dpc-12.5 dpc. After 13.5 dpc, the level of expression decreases. Expressed at 9.5-10.5 dpc in the neural tube, in somites and limb buds
+First expressed at 11 hours post-fertilization (hpf) in the dorsal presomitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 9. At 24-26 hpf, posterior expression begins to weaken and is undetectable by 40-56 hpf
+First detected at 7 dpc. At 13.5 dpc, expressed throughout the embryo, including forelimb, gut, head, heart and lung. At 17 dpc, expression becomes more restricted, with high levels mainly in the thymus, skeletal muscle, brain and spinal cord
+Fetal kidney
+Expressed in embryo and endosperm
+Widely expressed in embryos during development with particularly high expression in the spinal cord at 13.5 dpc
+In flowers, mostly restricted to sepals and pedicels
+Progressively increases throughout meiosis (at protein level)
+Level of expression increases with embryonal development
+Expressed in fetal heart, lung, brain and to a lower extent liver
+Expressed both maternally and zygotically. Expressed at the mid two-cell stage and in the embryo at 7, 11, 15 and 17 dpc
+Not detected in fetal tissues
+In flowers, restricted to the stigma and anthers
+Detected immediately after birth in the livers of animals of both sexes, but increases with age in females, whereas it is gradually reduced in males, resulting in predominantly female-specific expression in livers
+Appears in elongating/condensing spermatids when histones are still detectable (PubMed:15163613). Coexpressed with H2ab1 during late spermiogenesis (PubMed:28366643)
+Expression starts at 11 dpc in parallel with the onset of development of the central nervous system
+Expressed in embryos, larvae and adults (at protein level) (PubMed:15664654, PubMed:16857685). Expressed in the ecdysed cuticle during molting (at protein level) (PubMed:16857685). In embryos and larvae, expressed in intestinal, hypodermal and pharyngeal cells (PubMed:16857685). Expression transiently increases during early embryonic stages and prior to the larval L1/L2, L2/L3, L3/L4 and L4/adult molts (PubMed:16857685)
+Expressed mainly in the endosperm and surrounding maternal tissues during seed development
+In seedlings, present at low levels in the vascular system of cotyledons, leaves, hypocotyls, roots and hydathodes (PubMed:18267944). In roots, accumulates mostly in the zone of cell division proximal to the root tip, in the vascular system and primordial cells of lateral roots and, at low levels, in some superficial cells of the elongation zone (PubMed:18267944). In mature plants, observed in the vasculature of leaves, stems, and roots, with a progressive expression increase in mesophyll cells during aging (PubMed:18267944). Weakly detected in the young parts of the bolting stem (PubMed:18267944)
+Expressed after flower initiation
+Expressed in embryonic heart (at protein level) (PubMed:19483677). At 11.5 dpc expressed in limb buds, ventromedial parts of otic vesicles, endocardium, and weakly in the spinal cord and the brain (PubMed:11688560). At 14.5 dpc expressed in limb buds, anorectal region, developing olfactory bulb, nose and eye. At 10.5 dpc, expressed in the nephrogenic primordium (PubMed:11688560). At 11.5 dpc, expressed in mesonephric tubules and Wolffian ducts, and in the metanephric mesenchyme surrounding the ureteric bud (PubMed:11688560). At 14.5 dpc, expressed in the mesenchyme around the ureteric buds and weakly in comma-shaped bodies of metanephric tubules, but not in glomeruli, in the cortical regions of the developing kidney (PubMed:11688560)
+Expressed in early human development as well as in a limited number of adult tissues
+Expressed throughout embryogenesis and during postembryonic meiotic divisions that produce sperm in males
+Expressed in larvae, pupae and adults (PubMed:12110301). Expressed at low levels in larvae, then expression increases at the beginning of pupal development to reach high expression levels in adults (PubMed:12110301)
+Expression is maintained at a moderate level throughout development from embryo to adult
+Expressed in fetal liver blood cells (at protein level). Highly expressed in fetal liver
+Strong expression in the early embryonic stages 8 dpc, 9 dpc and 10 dpc in the neuroepithelium and by the maxillary arches
+Expressed during the transient accumulation of starch in the developing seeds. Decline rapidly 8 days after flowering. Not detected in mature seeds
+Expressed during late stages of embryogenesis and larval L1 stage
+Expression peaks in September/October in concomitance with germ cell maturation
+Expressed moderately during embryonic stages (0-18 hours) but then declines in late stage embryos (15-21 hours)
+After the eighth true leaves emerge, the expression gradually fades away from the center of the leaves toward the edges, as leaf development proceedes. In fully expanded leaves, expressed only at the edge of the leaf blade
+Expression first detected in the male gonad at 13.5 dpc, at the onset of testicular differentiation, and at 17 dpc in cell aggregates of the early ovary; then only in some cord cells of the older ovary. Expressed in fetal lung epithelium at 20 dpc. Detected at 13 dpc, sparsely distributed throughout the cytoplasm in the single layer of periderm cells covering the dorsal epithelium of the fetal tongue. Expression increases in the lingual periderm cells at 17 dpc and then disappears at 19 dpc coinciding with the disappearance of the periderm cells at the onset of squamous stratification of the lingual epithelium. Expressed at day 2-3 postnatally in older, elongated taste bud cells and at day 5, uniformly distributed throughout the epithelium of villi, intervillus epithelium and developing crypt buds of the small intestine
+Expressed as early as 5 days and thereafter shows little variation throughout 17 days
+Detected in inflorescence and youg floral mersitems, and in stem procambial cells. In floral mersitems, mostly expressed in the central dome. Disappears progressively from sepal primordia, but accumulates in second, third and fourth whorl organ primordia. Later, confined to occasional patches in stamens and in petal before disparearing progressively from flowers
+Pepsin A-2 is predominant at the 4-month stage. Pepsin A-3 is predominant at fetal stages
+Expressed during seed maturation. Expressed at three fruit developmental stages, at early stage (approximately 45 days before harvest), at middle stage (approximately 30 days before harvest) and at the final harvest stage. Higher level of expression before the harvest, then decreasing as seeds get close to their ripeness point (Ref.9). Expressed in raw seeds (PubMed:22616776)
+At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 7. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 3/somite 4 boundary
+Expressed in the upper granular cell layer of dorsal lip and tongue, palate and dorsal epidermis of newborns (PubMed:15226441). Expressed in the corneal epithelium and conjunctiva, with expression prevalent in the cytoplasm of anterior lens epithelial cells, becoming predominantly membrane expressed in epithelial cells as they elongate into fiber cells at 3 weeks of age (PubMed:19029034)
+It is moderately expressed in the cerebellum on postnatal day 7 in the external granule and Perkinje cells, increases in the second postnatal week and thereafter decreases to an adult level
+Expressed both maternally and zygotically. Zygotic expression is highest in pupae
+In young seedlings, expressed in the shoot apical meristem (SAM) and in root tips (PubMed:22897245). In inflorescence, observed only in young floral buds and seeds (PubMed:22897245). Accumulates at the late bicellular pollen stage and levels gradually strengthened from the tricellular pollen stage to the mature pollen stage (PubMed:22897245)
+Expression is high in early embryos, reduced in late embryonic and larval stages, up-regulated at the early prepupal stage and then reduced until the adult stage where it is again up-regulated
+Expressed in the ectoderm and then in primordial germ cells (PGCs). Expressed in testis from embryos (13.5 dpc) to adulthood in gonocytes and spermatocytes
+Expressed in shoots of 4 day old dark-grown seedlings
+Expressed in the placenta, yolk sac, limb buds, brain, spinal cord, retina, nose, bone and brown fat at the prenatal stages
+First seen at 9.5 dpc. From 9.5 dpc to 11.5 dpc, it remains uniformly present in the ventral part of the entire neuroepithelium and in the dorsal root ganglia. A more restricted central nervous system (CNS) expression is observed at 13.5 dpc and 15.5 dpc when it is present in specific regions of the forebrain, midbrain, hindbrain and spinal cord
+Expressed both maternally and zygotically, no expression is seen in larvae and weak expression in pupae
+Expression increases during transition to multi-cellular stages. During sexual development, displays a significant increase in fusion competent cells
+Highly expressed in earlier growth stages in hypocotyls, roots and the vascular bundles of the leaves. Detected later in the vascular bundles of the basal leaves aera
+Early in the developing heart, uniformly expressed throughout the entire cardiac crescent. Upon formation of the linear heart tube, expressed in a graded fashion, stronger near the posterior end and weaker at the anterior end. As the heart tube loops, asymmetric expression continues; it is expressed in the presumptive left ventricle, but not the right ventricle or outflow tract. This pattern of expression is maintained in more mature hearts (PubMed:10373308). First detected in the presumptive wing and leg mesoderm respectively at around stages 14-15. As limb outgrowth proceeds, expressed throughout the mesoderm and in the wing (PubMed:9550719)
+Detectable in embryo limbs at day 15, reached a maximum in newborn, and declined in adult limb muscles. During heart development level remains steady from embryonic day 15 to adult stage
+Yeast and hyphal stages, the latter having a higher specific activity
+Expressed early and persistently in chronically rejecting cardiac allografts but is absent in cardiac syngrafts and host hearts. In the embryonic cerebellum, expression peaks at day 7
+Up-regulated during osteoclastogenesis induced by treatment of peripheral blood mononuclear cells with CSF1 and TNFSF11, as well as during osteoblastogenesis
+Maternally expressed. Ubiquitously expressed in embryos and throughout development
+Developing leaves. Present at highest levels in very young ligules and auricles. Present pre- and post-ligule and auricle development
+Detected at low levels in brainstem from neonates; increases tenfold during the first 29 days after birth
+Expressed in follicular cells of the developing thyroid at 18 dpc (at protein level)
+Expression is kept at constant levels after the onset of development. During sexual development, displays a significant increase in fusion competent cells
+Expressed in the developing neocortex, both in the late precursor cells and in the migrating neurons
+Isoform 3 is expressed in fetal liver
+Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks and its relative proportion declines thereafter
+Expressed during late embryogenesis, larval instars, late stages of pupariation and adult
+Broadly expressed from 9 dpc to 11 dpc, with some enrichment in neural tube-derived tissues. By 15 dpc, the expression is largely restricted to neuroendocrine tissues
+Expressed in vegetative cells and heterocysts
+First appears at the 2-cell stage, intensifies during the 8-cell and compact morula stages, but subsides in the blastocyst
+Detected in the egg cell and the central cell of the embryo sac, but not in the synergids, the antipodals or the male gametophyte. After fertilization, it is expressed in the zygote. After the first division of the zygote, it is detected exclusively in the apical daughter cell, while WOX8 is expressed in the basal daughter cell. Subsequently, it is expressed in all cells of the 4-cell embryo proper and predominantly in the apical domain of the 8-cell embryo. However, in some 8-cell embryos it is also weakly expressed in the central domain suggesting that expression shifts to the most apical cells during this stage. Expression remains restricted to the apical domain in the 16-cell embryo and the early-globular stage. Not expressed in the apical domain thereafter. However, in heart stage embryos it is weakly expressed in a ring of epidermal cells approximately at the junction of hypocotyl and root. Not expressed in mature embryos, endosperm or postembryonically in inflorescences
+Expressed throughout development. Highest expression occurs during 12-15 hours of embryonic development (at protein level)
+Expression in the developing nervous system is transient and restricted to cells lining the ventricular zone that have ceased proliferation but have not yet begun to migrate into the outer layers. In retina, neurom is also transiently expressed in cells as they withdraw from the mitotic cycle, but persists in horizontal and bipolar neurons until full differentiation. In the peripheral nervous system, its expression closely follows cell proliferation
+Present in both spores and vegetative cells
+Detected in developing and mature leaves of adult plants. Levels of PD-L3 and PD-L4 are highest during the spring and summer, fall in autumn and are low during winter. Not detected in young (8-34 month old) plants
+Expression is first detected in immature oocytes just after germinal vesicle breakdown (GVBD). Expression remains throughout both meiotic cycles, unless fertilization occurs, and disappears after fertilization (at protein level)
+Expressed in developing laminar joint and meristematic regions
+Expressed both maternally and zygotically. Expression accumulates through oogenesis, remaining more or less constant at the beginning of embryogenesis, to slightly increase later on (at protein level)
+In juvenile testes, expression is absent prior to postnatal day 12, is detected at a low level at day 12, and increased significantly at day 14 and beyond. In adul testes, expressed in meiotic spermatocytes, abundant in post-meiotic haploid round spermatids, and absent from elongated spermatids
+Weakly expressed in embryos
+Expressed in heart, muscle, brain, liver, thigh, stomach and lung at 14 dpc (at protein level). Expressed from the two-cell to blastocyst stages. Expressed in tail region, somites, cephalic structures and limb buds at 10.5 dpc
+Observed in maturing tracheary elements (TE) in the root maturation zone
+Both isoforms are expressed during pupal and adult stages
+First detected at 8.5 dpc, when neural crest cells are visible at the lateral ridges of the neural plate. During embryogenesis, it is expressed in mesoderm, in the neural crest (and its target tissues) and in neuroepithelium
+Constitutively expressed in flowers with a higher level at the stage of buds
+First expressed during the L3-L4 stages of larval development, coinciding with germline proliferation
+Repressed in the bacteroid form during symbiosis
+Expressed throughout the developing central nervous system, but excluded from the most medial ventricular zone (PubMed:26056227)
+Highly expressed in seed endosperm 7 days after pollination
+All developmental stages, but not dauer larva
+Expressed at highest levels during the G1 to S transition of the cell cycle
+Expressed in 12-22 hours embryos. Expression peaks in larvae and declines in pupae and adults
+Ubiquitously expressed in early stages of embryonic stem cell differentiation but decreases at later stages when high expression is restricted to cardiomyocytes
+At postnatal day 4, expression is apically located in the inner and outer hair cell region of the entire organ of Corti. By postnatal day 8, expression is highest in the supporting cells of the organ of Corti
+First expressed between embryo days 8 and 11. In the liver, expression increases during development from embryo day 13 to adulthood while, in the spleen, levels remain constant throughout development
+Expressed during the asexual blood stage, including at the schizont stage and in free merozoites (at protein level)
+Expressed both maternally and zygotically, during early to mid embryogenesis and early pupation
+Detected only in the oocytes throughout oocyte maturation period
+Expressed in endothelial cells of allantois/umbilical vessels at 8.5 dpc (at protein level). During hemangioblast differentiation, expressed in hemogenic endothelium cells and down-regulated in nascent blood precursors
+Expression is not detected before the 3-somite stage at 10-11 hours post-fertilization. Earliest expression is detected during mid-neurulation
+RTD-1 expression begins early during granulocyte myelopoiesis
+In early embryos expression is ubiquitous (PubMed:25344753). From mid-embryogenesis (stage 16) and throughout larval development, expressed in the prothoracic gland cells of the ring gland (PubMed:25344753, PubMed:25300303). Weak expression in the follicle cells of the ovarioles in developing egg chambers (at protein level) (PubMed:25300303)
+PodJS, from the previous progeny, accumulates in the swarmer cell, and is partially degraded during the swarmer-to-stalked transition by sequential proteolytic cleavages (MmpA). PodJL, from the new progeny, is synthesized in the early predivisional cell, and then is likely to be converted to PodJS by proteolytic cleavage of periplasmic domain. After cell division, PodJL disappears, while the level of PodJS increases in the swarmer cell progeny
+Expressed in the scutellum and leaf primordium of fully mature seeds (PubMed:17333504). In germinating seeds, expressed in the vascular bundle of the scutellum, the coleoptile, the bud scale, the coleorhiza, and the base of the seminal root (PubMed:17333504)
+Maternally transcript whose a low level of expression persists during the cleavage and gastrula stages and a significant increase was observed at the end of the gastrula stage. Mainly localized to the ectoderm at the early gastrula stage and then shifted to the embryonic neural tissues, whereas adult brain had decreased levels of expression. Strong expression in the germinal epithelium of the embryonic brain (especially the diencephalon and rhombencephalon) and neural tube, in the lens and the cranial ganglia. The epithelium of the developing gut, like the pharynx and esophagus, also prominently expressed it. Other sites of expression were found in the liver and in the mesenchymal condensation sites of branchial arches
+Expressed during development; especially between 8 and 14 hours of development. Expression reaches a maximum at around 16 hours, when the cell aggregation was near completion and phagocytosis started
+Expressed in elongating hyphae but not in budding yeast cells (PubMed:8359888)
+Overexpressed in tumor cells lines with a t(11;14)(q13;q32) translocation
+Expressed in adult but not larval guts, whole pupae or whole bodies minus gut
+In the embryo, expressed at day 7 dpc, 11 dpc and 15 dpc
+In the embryonic male gonad, expressed in somatic cells as early as 11.5 dpc and persist throughout development. Expression is detected in peritubular myoepithelial cells in the postnatal testis, while expression is absent in developing and adult ovaries
+Expressed at the late stage of pollen development in tricellular and mature pollen
+Expressed during oogenesis, embryogenesis, and organogenesis
+Accumulates transiently in developing seeds (e.g. including embryos and seed coat), reaching a peak ten days after pollination (10 DAP) (PubMed:32354877). Observed in young seedling and progressively restricted to vascular tissues. Present in whole blade of young leaves but confined to the vascular tissues of mature leaves. In stems, mostly present in xylem, mature phloem and differentiating fibers. In siliques, only present in the lignified extremities. Expressed during early and late stages of flower development
+Isoform 1 is barely detectable at 17 dpc and increases in intensity until postnatal day 15, when it reaches adult levels. Isoform 2 is detectable from postnatal day 5 and reaches adult levels also at postnatal day 15
+Predominantly expressed in embryos and in the adult germline (at protein level). Only present in mitotic cells; at the anaphase and telophase, its begins to degrade
+Expressed in developing brain, mammary bud, thymus, teeth, whisker follicle, intervertebral disks, olfactory epithelium, eye, stomach and limbs
+Expressed in germ cells of L4 larvae (PubMed:33231880). Expressed at low levels in the pachytene stage of the meiotic region of L4 larvae (PubMed:33231880)
+Isoform 2 is expressed in developing thymocytes from the CD44+CD25- stage up to mature T-cells. Isoform 1 is not expressed in thymocytes at the CD44+CD25- or CD44+CD25+ stages
+Expressed in the retinal inner nuclear layer and outer nuclear layer at postnatal day 8 (P8) (PubMed:30936473). Expressed in retinal dopaminergic amacrine cells in the retina at P8 and P15 (PubMed:30936473)
+Expressed in developing spinal cord from 13 dpc to postanal day 1, not expressed in adults (PubMed:8290353). Expressed by few neurons of dorsal root ganglion from, at least, 10.5 dpc to 15.5 dpc (PubMed:22326227)
+Expressed between 6 and 19 weeks post-conception (WPC) in the outer neuroblastic zone, inner neuroblastic zone, and inner plexiform layer of the retina (at protein level) (PubMed:29777959). Expressed at the surface ectoderm at 6 WPC and the neural retinal at 6 to 8 WPC (at protein level) (PubMed:29777959). Expressed in the interphotoreceptor matrix and abundantly in developing photoreceptors between 12 and 19 WPC (at protein level) (PubMed:29777959). Isoform 1: Highly expressed from birth through 8 years of age and is down-regulated by 20 years of age to low levels that are maintained in the normal adult cortex (PubMed:11054543). Isoform 2: Expressed at uniformly low levels throughout development (PubMed:11054543)
+Highly expressed in L2 larvae and adult insect stages, which are the main feeding phases. Low levels are detected in eggs and first instar (L1) stage, whereas a 200-fold increase is observed at the second instar (L2) stage. Expression is significantly reduced during the pupal stage, a period in which the insects do not feed. After ecdysis, the expression increases again 200-fold during the adult stage along with the resumed feeding
+Highly expressed during meiosis and sporulation (at protein level)
+First detected in the stigma papillae of the flowers at stage 11, and then in the pollen grains before and after fertilization
+Isoform a and isoform b are expressed in embryo and in all larval stages
+Broadly expressed in the developing imaginal disks including the wing, leg and eye, and the neuroepithelium of the optic lobes of the brain. In the eye imaginal disk, expression is highest in the morphogenetic furrow and in the wing imaginal disk it is highest near the dorsal-ventral (DV) compartment boundary
+Accumulates progressively in panicles before and after heading with highest levels at maturity (pollination stage)
+Accumulates in tissues undergoing abscission
+Expressed in cells competent for DNA transformation; that is 5-10% of the population (PubMed:11918817)
+First appears in embryos, levels decrease in larvae and peak again in 1 day old pupae. No expression is found in adults
+Appears after the first haploid mitosis and are expressed during microgametogenesis, germination and tube growth
+In the fetal kidney, detected in the developing mesangium, ureteric bud epithelium and the undifferentiated mesenchyme (at protein level)
+First detected in the developing spinal cord and becomes widespread as development proceeds
+Expressed in the embryonic cortex and germinal ventricular zone (PubMed:27404227). Expressed in cells of the cortical plate and in retinal pigment epithelium and lens between 12 and 14 dpc (at protein level) (PubMed:27404227)
+Not expressed in L2 and L3 larvae (at protein level) (PubMed:10743611, PubMed:12742584). Expressed at very low level in L3 larvae (at protein level) (PubMed:17933581). Expressed in host lung L3 larvae (at protein level) (PubMed:17933581)
+Expressed at highest levels in vegetatively growing cells and declines during development (at protein level)
+At 9 dpc, the expression is strong in the neuroepithelium of neural tube and in placenta. At 13 dpc, the expression is still observed in neuroepithelium. Furthermore, strong expression is seen in lung, kidney, intestines, thymus and liver, and a moderate signal is detected in the cartilage primordium of developing ribs, tooth and eye. By 17 dpc, the tissue distribution changes so that no signal is detected in the liver and the signal has diminished in other organs. It is observed for the first time in the salivary gland, thyroid gland and brown fat and was strong in the thymus, eye, olfactory epithelium and central nervous system. At 1.5 days after birth, the expression is still strong in thymus, but weaker and more limited in brain
+Present in the acrosome of spermatids up to the late cap-stage, but not in mature spermatozoa
+Levels fade progressively in a basipetal fashion as the leaf develops
+Expressed during embryogenesis (PubMed:14614497). Detected in the embryonic and seedling root meristems (PubMed:14614497)
+Expressed in several fetal tissues including kidney, thymus, spleen and lung
+At 11 dpc expressed throughout the entire neuroepithelium. In the developing brain, expressed in the forebrain, tectum, cerebellum, striatum and olfactory bulb. At 15.5 dpc expressed in the cortex; the dorsal part of the telencephalon becomes laminated, and expression is observed in the upper and ventricular layers. At 18.5 dpc expression in the ventricular zone is weak
+Expressed in hypodermal cells in L1 larvae (PubMed:11441002). No expressed in embryos (PubMed:11441002)
+Expressed both maternally and zygotically. During oogenesis it accumulates in the nurse cells of developing egg chambers
+Secreted from the early stationary phase until the time the cells cease to grow
+Expressed at the time of spicule formation in the embryo
+Accumulates in differentiating cells starved just before the PS point, while there is no detectable expression in vegetatively growing cells
+Maternally expressed. Accumulates in the developing oocyte
+Levels increase steadily throughout imbibition reaching maximum levels at day 7. During germination, levels increase from day 2, reach maximum levels at day 3 and decline after day 5
+Expressed in oocytes and preimplantation embryos with expression peaking at the blastocyst stage
+During the embryonic stages, high expressed in the brain, spinal cord, sensory ganglia (dorsal root and trigeminal ganglia), and thymus. In brain found throughout the ventricular and marginal zones. Expressed mainly in neural tissues
+Abundant in embryos younger than 50% of embryonic development
+Expressed at high levels in fetal lung, kidney and heart
+Early expressed in the development of root hairs within the root differentiation zone. Expressed late in the development of leaf trichomes when the stalks and branches are expanded
+Expressed at relatively high level at 7 days old embryo compared to those at stadges day 11, 15 and 17
+Expression is restricted to and present throughout the embryonic CNS and developing peripheral neural structures. In the embryonic CNS, expression is restricted to postmitotic neuronal regions. During the neurogenetic period (11 dpc-17 dpc) expression is associated temporally and spatially with the known generation of the first cortical neurons with known gradients of neuron production. Expression continues in developing postmitotic cortical neurons throughout embryonic development and is expressed within 2 days of neuronal induction in P19 cells
+Expressed early in testis differentiation specifically in Sertoli cells of the developing testis cords
+Expressed from the egg to the tailbud stage embryo. Expressed at late gastrula/early neurula stages of development within the posterior neuroectoderm. Expressed in primary neurons as they differentiate in the neural plate at stage 14.5 in the area of the trigeminal placodes. Expressed in the cement gland at stage 17. Expressed during later phases in the notochord in tissues derived from dorsolateral cranial placodes
+Detected from 30 hours post-fertilization to 4 days post-fertilization in Schwann cells of the posterior lateral line nerve
+In fetal brain exclusively in neurons of the subependymal region of hypothalamus lateral to the third ventricle
+In the developing respiratory system, expression is restricted to the lung epithelium at 14.5 dpc. At 14.5 dpc and 16.5 dpc, expressed in the epithelium of the esophagus, small intestine, stomach and pancreas. At 16.5 dpc, detected in bronchial epithelium. In the developing skeleton, expressed in the perichondria of developing ribs at 14.5 dpc. In developing skin, expression is detected in the most suprabasal layers at 16.5 dpc
+Expression is first detected at postnatal day 16 (P16) and increases significantly at days P30 and P42
+Expressed transiently during flower develoment in the anthers and developing siliques (specifically in the maternal tissues), mostly in the pollen and the tapetal cell layer during pollen maturation
+Enriched in adults
+Expressed in embryos 48 to 96 hours post-fertilization (at protein level) (PubMed:32075961). Expressed in both ventricular and atrial cardiomyocytes (at protein level) (PubMed:32075961)
+Expressed in early embryo throughout the ectoderm at 6.5 dpc and in visceral endoderm overlying the extraembryonic ectoderm at 7.5 dpc. Not present in the mesoderm nor in endoderm emerging from the primitive streak (PubMed:15142971). Expressed in differentiating osteoblasts that contribute to the lateral membranous part of clavicle at embryonic day 13.5. Expressed in osteoblasts lining the bony trabeculae of the humerus at embryonic day 16.5. Expressed in osteoblasts on both surfaces of the temporal bone at embryonic day 17.5 (PubMed:11719191)
+Highly expressed in embryonic brain but its expression decrease during development
+First detected at 9.5 dpc in heart at the edge of both sides of the common ventricular chamber and is then progressively increased and restricted to the myocardial wall of left common ventricular chamber of heart
+Expression increases during the larval stages to adulthood
+Abundant in embryos, fourth larval stages and adults
+Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation
+Mainly observed in the apical region of the adult gametophore, new branches forming on the side of the mature gametophore and in the tissue immediately basal to the immature sporophyte. Also detected in the antheridia. Expressed at the tips of the protonema side branches and in lateral buds of the chloronema
+Expressed maternally. Present during oogenesis and early stages of embryogenesis
+Expressed meiotically and post-meiotically
+Expressed during the parasite blood stage, including in schizonts (at protein level) (PubMed:8631352). Expression is weak in ring, early trophozoite and increases in the late trophozoite and early schizont stage (PubMed:8774709)
+Accumulates strongly from the leaf opened to the green fruit stage (PubMed:30577538). High levels are maintained until the red fruit stage, but decrease drastically during the root growth stage (PubMed:30577538)
+At 5 dpf, expressed in the hair cells of the inner ears and the lateral line neuromasts
+Expressed in most cells during embryonic development (PubMed:15328017, PubMed:15649460). First expressed at around the 100-200 cell stage of embryogenesis (PubMed:15328017, PubMed:15649460). Expression was absent or reduced in intestinal cell lineages during this time. Highly expressed in neuronal cells of the head, ventral nerve cord and tail during the late stages of embryogenesis (PubMed:15328017). Highly expressed in all dividing cells after hatching (PubMed:15649460). Highly expressed in the P lineage during the L1 stage of larval development (PubMed:15649460). During larval development, mainly expressed in the neurons, but there is also high expression in the junctional cells of the spermatheca and uterus, and weak expression in cells of the somatic gonad including the distal tip cells (PubMed:15328017)
+Light-dependent expression. Developmentally regulated. First observed in cotyledon vascular tissues of young seedlings. Appears at the shoot apex, in the upper part of hypocotyls and in roots in one week old seedlings. Later highly expressed in the basal portion of trichomes, veins, shoot apex, and hypocotyls. Becomes restricted to the margins of leaves and in roots. In drakness and blue light (B) grown plants, localized in cotyledons vascular tissues. In far-red (FR) and red (R) light conditions, mostly confined to regions of vascular tissues near the hydathode of cotyledons. In adult plants, expressed in vascular tissues of flower organs
+Expressed in the salivary gland, anterior and posterior midgut primordia, the fully formed midgut, amnioserosa, malpighian tubules, several regions of the head, and in isolated cells along the germ band, which are likely to be hemocytes
+Expression is first detected during embryogenesis at the beginning of morphogenesis and continues in a subset of larval tissues and in adult neurons
+Expressed in the posterior cells of the intestine in L4 larva
+Detected throughout development
+Predominantly expressed in developing and mature photoreceptors (at protein level)
+During anther development, accumulates in anther primordia during archesporial cell specification and later present in a horseshoe pattern associated with the lateral and adaxial portion of primordia, prior to the emergence of distinct locules. Expressed throughout sporogenic tissue and surrounding cells layers in adaxial and adaxial locules. Localized to the tapetum and middle layers, gradually fading postmeiosis with degeneration of these cell layers
+Expressed at prebloom in flower buds but barely detectable after anthesis and in early stages of fruit onset. Detected again two months after flowering, then increases and reaches a maximum when the fruit is at peak maturity. Also expressed in very young seeds
+Significant levels were first detected at the 14-somite stage (16 hours post-fertization; hpf) and increased by the prim-11 stage (28 hpf). At 16 hpf expression is observed in a small subset of neurons in the spinal cord and at 18 hpf in the developing hindbrain. At 28-32 hpf, significant levels of expression is seen in presumptive neurons along the rostral-caudal axis of the hindbrain and the spinal cord. During later stages of development expression is restricted to the developing retina and no longer detected in the hindbrain or spinal cord
+Expressed in the developing fetal lung epithelium and embryonic ventral node (at protein level)
+Strongly expressed in vegetative cells with expression levels steadily decreasing during differentiation. After 12 hours of differentiation mRNA expression levels are very. slightly expressed
+First expressed at the 1-somite stage. At the 10-somite stage, weakly expressed in the paraxial mesoderm with an anterior expression limit at somite 1. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit adjacent to the rhombomere 7/8 boundary
+Synthesized in the fully form of sporont
+Expressed in the prestalk cell type pstAB, or at the stalk entrance during culmination and slug stage, this expression being weak in the dstA null mutant
+Expressed by secretory stage ameloblasts and by odontoblasts at postnatal day 5. It is not detected in maturation stage ameloblasts and only residual expression is observed in odontoblasts by postnatal day 12
+Highly expressed throughout whole developmental stages. Transient increase in embryos at the globular stage
+Expressed in developing embryos
+Decreased expression in the yellow and red fruits, after the breaker stage
+Expressed throughout development, with high levels of expression in adults and low levels of expression in larvae and pupae (PubMed:16672980, PubMed:16672981). Adult males display higher levels of expression than females (PubMed:16672980)
+Expressed in newborn larvae, precyst muscle larvae, postcyst muscle larvae and adult worms
+Expressed 24 hours after initiation of photoreceptor cell differentiation, persists through development to adulthood
+Developmental protein. Present as a maternal component before zygotic transcription begins. Detected in animal, marginal and vegetal regions in late blastula and gastrula embryos. Later expressed in the neural tube, in the medial intermediate, and later neurons. Detected in the eyes at stage 25 until stage 28. At stage 35 not detected in the eyes but in the otic vesicles
+Expression relative to adult is increased in the L3 stage and more so in dauers
+Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway
+Accumulates steadily during G2 and is abruptly destroyed at mitosis. Very low levels are seen in stationary-phase cells (0 hour) which then increase to a maximum between 5 and 6 hours (at which time cells begin to divide). Protein levels then decrease until the end of cell division
+Expressed in the germinal vesicle of oocytes at stages I-III. Expressed in ectodermal and mesodermal cells and their derivatives after stage 10. At stages later than 28, highly expressed in the myotome, spinal cord and notochord (at protein level)
+Expressed in developing brain in a specific temporal and spatial pattern
+During grain filling, expression increases from 4 to 20 days after pollination and then decreases to basal levels
+Expressed in the developing podocytes during glomerulogenesis
+Expressed in muscles and neurons from embryogenesis to adulthood (PubMed:15282156, PubMed:27855782). First expressed post-fertilization, then accumulates in anterior cells of the embryo that give rise to neuronal and mesodermal tissues and body wall muscle cells, where expression persists and increases (PubMed:15282156). Also expressed in posterior nuclei post-fertilization (PubMed:15282156). At the 2-fold stage of embryogenesis, expression is restricted to fewer cells (PubMed:15282156)
+At 16.5 dpc and 18.5 dpc expression is cartilage specific. In tracheal and nasal cartilage, expression is seen throughout all chondrocytes at a similar intensity while in other cartilage tissues undergoing endochondral ossification, intensity is strongest in proliferating and prehypertrophic stages. In knee epiphyseal cartilage, expression is detected from 12.5 dpc onwards, with significant up-regulation at 16.5 dpc and again at postnatal day 5. Expressed at least until 10 months of age
+No significant variation in expression during cell cycle
+Expressed primarily during embryonic, larval and early pupal development and at low levels in late pupae and adults
+Expressed in developing oocytes (at protein level)
+Abundantly expressed in developing central nervous system, with highest levels in cerebellum and lowest in telencephalon
+Expressed both maternally and zygotically. Levels accumulate during oogenesis (at protein level)
+Highly expressed in all organs except heart and liver (12.5 dpc and 14.5 dpc). The level of expression gradually diminishes as embryos develop, with expression restricted mostly to the CNS and thymus at 18.5 dpc. Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5 dpc-16.5 dpc
+Expressed at 12.5 dpc in dorsal root and cranial glanglia in the developing brain. Detected at 14.5 dpc in skin epidermis (at protein level). First detected at 10.5 dpc in the dorsal root glanglia and cranial glanglia. At 12.5 dpc expression appears in retina, forebrain and outside of the nervous system. At 13.5 dpc a strong expression is detected in the cortex. Expressed in embryonic, newborn and adult skin
+Preferentially expressed in the dorsal-temporal quadrant of the developing retina. There was a sharp increase in retinal SSAT levels during the transition stage from proliferation (7 dpc) to early differentiation (10 dpc). SSAT was found in Muller glial cells and its distribution pattern in these cells closely followed the three differentiation axis of the developing retina, with a central-dorsal-temporal preference
+Accumulates in macrocysts
+Not expressed in embryos and L1 stage but expressed from L2 stage to adulthood in the body wall muscles (at protein level)
+Expressed specifically in symbiotic conditions with S.meliloti, especially in cortical cells in close contact with rhizobial infections. Accumulates in nodule primordia. In young nodules, confined to the apical regions. In mature nodules, present in a broad apical region encompassing the pre-infection, infection, and early nitrogen fixation zones (PubMed:20971894). Expressed at all stages of arbuscular mycorrhizal (AM) fungal infection in epidermal and cortical infected cells, and in cells in their close vicinity. Two weeks after inoculation with R.irregularis, confined to localized areas associated with the presence of the fungus. Later expressed in epidermal cells directly associated with visible hyphopodia forming on the root surface, and in a few restricted outer cortical cells in the immediate vicinity. In fully colonized roots, observed in infected outer cortical cells and in surrounding cells. Also detected both inside and in the vicinity of inner cortical cells containing arbuscules (PubMed:26839127)
+First detected during early neural plate formation (stage 13) and increased at the early tailbud stage (stage 28) (PubMed:23716681). Expression is higher around the anterior neuropore in the neural plate than in the rest of the embryo, and as embryogenesis proceeds, is present in the forebrain, midbrain, and presumptive eye of the embryo (PubMed:23716681)
+Detected in oocyte, embryo, larval stage 1 to 4, and in adult
+Expressed in fetal tissues. Strongly expressed in fetal liver
+Detected maternally in mature unfertilized oocytes and ubiquitously expressed until embryonic stage 16. In stage 17/18, expression becomes restricted to the closing neural tube
+AAL is detected in fruiting bodies but not in mycelia (PubMed:2193930)
+Expressed in the forespore
+Accumulates in an adaxial ball-shaped set of cells in three to five cell layers around the L3 layer of the shoot apical meristem (SAM) in youg plantlets. Later, expressed transiently at the center of the boundary between the SAM and developing leaf primordia. In the inflorescence meristem, confined to the axils of flower primordia
+High level expression in cerebellum of newborn rats is down-regulated to 50% by postnatal day 14
+Expression takes place in the secondary-growth phase initiated by nutrient depletion
+Expressed at higher levels in adult brain than in developing brain
+Expressed maternally and zygotically. Expressed during embryonic development
+Expression begins around stage 10 in weak epidermal stripes (PubMed:8269517). Nervous system expression is first detected around stage 15 and at stage 16 appears to remain restricted to a small subset of neurons (PubMed:8269517). Beginning around stage 14 to 15, also expressed in the ventral intersegmental 5 (VIS5) muscle of thoracic segment T3 (PubMed:8269517, PubMed:27618755). It is also expressed in the embryonic gonads and in anterior sensory organs, including the maxillary complex (PubMed:8269517)
+Isoform SGG46 is expressed at low levels in 12-24 hours embryos. Isoform Zygotic and isoform SGG39 are expressed in 12-24 hours embryos and present throughout the larval, pupal and adult stages (at protein level). Isoform Zygotic is expressed maternally and zygotically but reduced throughout later embryonic development. Expression persists throughout larval stages
+Expressed from 11 dpc to 18 dpc
+Detected in embryo from 7 to 17 dpc
+In the embryo, expression starts at day 6.5
+Weakly expressed in outer cells of the two cell-layer ectoderm at embryonic day 14.5. Detected only in the intermediate cells, undetectable in the basal or outermost epidermal cells or the occasional follicular buds. In 17.5 dpc and 18.5 dpc epidermis expression is restricted to a single layer of suprabasal cells and is absent in the granular cell layer. Also present in the differentiated follicular cells at the apex of the 'horseshoeshaped' matrix. Detected throughout the limbal and corneal epithelium at day 1 of postnatal life, at day 5 of post-natal life it was no longer detected in the limbal epithelium
+Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle
+Expression is maximal during lag and early exponential phases of growth, decreasing upon further entry into exponential growth
+Accumulates in maturing endosperm
+Expressed in adult but not at postnatal day 1. In the seminiferous tubule, expressed in first layer capped spermatids at stage VII and in spermatids closer to the lumen of the tubule at stage XII. Not detected in spermatogonia, first layer of spermatocytes or mature spermatozoa
+Expressed during hypodermal development
+Expressed in skeletal muscle, lower levels in thymus and brain
+First expressed at 14 days postpartum (dpp). Levels increase dramatically between 14 dpp and 17 dpp
+Detected at 11.5 dpc in the developing brain, in the ventricular zones of the cortex and ganglionic eminences as well as in adult, in mature structures such as the granule cell layer of the dentate gyrus and cerebellum
+Highly expressed in invasive placental villi during first trimester
+Expressed in the developing eye and CNS prior to neuronal differentiation. First detected at around 18 hours post-fertilization (hpf) in the eye primordia and brain. At 24-42 hpf, expressed in most cells of the developing eyes, CNS and ears. At 48 hpf, also detected in the optic nerve and tracts. By 56 hpf, levels are barely detectable
+Detectable in lateral root development when they reach 1 mm long
+Expressed in developing buds, until the pollen is near to maturity
+Expressed from the G1 to the S phase
+Down-regulated during germination
+Expressed in the early pupae
+In embryos expressed in the brain and overlying head tissue. Expressed in the ventral nerve cord at the onset of commissural axon guidance toward the midline. Expression levels in the ventral nerve cord peak in 50 hour old embryos. By 52 hours expression becomes restricted and appears to be expressed specifically in neurons which cross the midline such as EG, RP1, RP3 and RP4. At 54 hours, when most commissural axons have crossed the midline, expression levels in the nerve cord was no longer detected
+Abundantly expressed during development of the central nervous system, in particular in proliferating neuroblasts and in cells at the initial stages of differentiation. Also expressed at high levels in morphogenetically active regions such as limb buds, somites and mesonephric tubules. Expression decreases once cellular differentiation is over
+Down-regulated during myeloid differentiation
+Expressed in the oocyte, expression is maintained at least until blastocyst stage
+Expressed in all stages examined from first instar larva to adult. Expression remains relatively constant throughout the larval stages and elevates slightly in adults
+Expressed in sensory neurons during embryonic development of the olfactory epithelium and vomeronasal organ. From, at least, 11.5 dpc through adulthood, expressed in the olfactory system. At 14.5 dpc, highly expressed in the olfactory epithelia, vomeronasal organ, the Grueneberg ganglion, the septal organ and the olfactory bulb (PubMed:23090999). At 14.5 dpc, expressed within germinal regions in the ventricular zone of the brain, the rhombic lip and the nascent external granule layer (EGL). At 16.5 dpc expression at the EGL is more intense and extensive. From P1 to P15, expressed in cerebellar granule neuron progenitor cells (CGNPs) of the EGL (PubMed:22095825)
+ABA treatment induced the synthesis of RAB-17 in calli, however, the RAB-17 proteins were found to be highly phosphorylated only in embryos
+In seedlings, accumulates in cotyledons and the hypocotyl, especially in the vein. In adult plants, mainly detected in mature leaves, particularly in vascular tissues. Also present in the vein of sepals and petals of flowers
+Induced steadily during photomorphogenesis
+In seedlings, first observed at the hypocotyl/root junction but later confined to the root, including root hairs. In flowers, expressed in the apex of stamen filaments at a very early developmental stage and disappeared before the flower opened. Not present in siliques
+In embryo, detected in the neuroectoderm at stage 8, and later in neuroblasts at stage 9 (at protein level) (PubMed:22357926). By stage 16, detected only in the neuroblasts (at protein level) (PubMed:22357926). In larvae, detected in a subset of neuroblasts, some of which will give rise to the optic lobe (at protein level) (PubMed:22357926). In embryo, detected during the initial stages of germ band exclusively within the neuroectoderm, both in the territory of the trunk and in cephalic regions (PubMed:1427040). During stage 9, detected within the procephalic lobe and the ventral ectoderm (PubMed:1427040)
+Expression is detected at 3 weeks of postnatal development and persists up to adulthood (PubMed:27032685). Expressed in elongated spermatids but not detected in spermatogonia, spermatocytes, and round spermatids (PubMed:27032685)
+Sudden accumulation in cotyledons of 4-day-old plants, but rapidly disappears about 12-14 days after the onset of germination
+Expressed during seed development, from 70 days after fertilization (daf) until full maturation and drying at 105 daf. Decreases rapidly after imbibition
+Neurula stage and in adult brain
+At 8.5 dpc, expressed in the primitive streak, rostral forebrain, cells lateral to the posterior hindbrain, anterior hindbrain and developing midbrain. At 9.5 dpc, continues to be expressed in the rostral forebrain and primitive streak, and is also detected in the branchial arches and the forelimb bud. At 10.5 dpc, expressed in the somites, frontonasal processes, tailbud, and hindlimb bud (PubMed:10498682). Highly expressed in lung epithelial cells, primarily in the distal airways at 12 dpc (PubMed:10074434)
+Expressed in the apical parts of the developing gynoecium. Detected throughout the youngest flower primordium. Later relocalizes towards the regions of the presumptive sepal anlagen and remains in sepal primordia until just after their emergence. Also observed on the abaxial side of the young floral meristem. Present in the newly arisen gynoecial primordium. Restricted to the apical parts of the carpels as the open-ended gynoecial cylinder elongates vertically. In the apical regions of the gynoecium, confined to a zone in the interphase between the style and the stigma and fades out later. Within the gynoecium, accumulates in ovule primordia, and, as the ovules developed, restricted to the epidermis of the developing funiculi, to the outer, but not the inner, integuments and to the tip of the nucellus. Also present in the cell layer of the septum that faces the ovary. In the embryo, detected in the cotyledon primordia during late globular to mid heart stage. In addition, transiently expressed in petal and stamen primordia and in the tapetum of the anthers
+Expressed initially during formation of apical tips in aggregates, accumulates rapidly during terminal cell differentiation, and peaks at about 21 hours. Expressed only in prespore cells
+Constitutive expression during ripening
+Low expression was detected in brain and spinal cord at birth, increasing with age to highest levels in postnatal days 60 (P60)
+Very low expression in young nodules, increasing in the later stages of development
+Overexpression leads to oncogenic transformation of NIH 3T3 cells
+Expressed at constant, but relatively low levels throughout development
+Decreases during leaf senescence, but still present after 8 days of dark-induced senescence
+Expressed only during the stationary growth phase
+Expressed by Lewis X-positive neural precursor cells in the ventricular and subventricular zones of 15.5 dpc embryonic brain
+P110/11E abundance is markedly elevated in promastigotes relative to amastigotes
+Expressed in the embryonic node at 7.5 dpc and in the nasal, lung, tracheal and brain ventricle epithelium at 18.5-19.5 dpc
+Expressed until four or five weeks after birth
+Expressed both maternally and zygotically. Expressed during embryonic, larval, pupal and adult stages. Weakly expressed during early embryonic stages but displays a dramatic increase at 12-24 hours of embryonic development. Continues to be in adult but displays much lower levels in the female adult as compared with the male
+Early expressed in the whole plant, but was restricted to lower stems, flower buds and roots in the mature plant (6 weeks old) (PubMed:11475326). Detected in cells throughout the embryo, including the suspensor, from the 32-cell stage, with expression increasing up to the torpedo stage, followed by a decrease at the bent-cotyledon stage, with little or no expression detectable in the nearly mature cotyledon stage of development (PubMed:12034904)
+Detected from 0.5 to 48 hours post-fertilization (hpf) (PubMed:16156897). At 24-36 hpf, expressed in adaxial mesoderm, somites, notochord, floorplate, hypochord, tail bud, eye, telencephalon, diencephalon, midbrain, hindbrain and otic vesicle (PubMed:17195182)
+Detected in the cochlear duct from 14.5 dpc (PubMed:22446089). Detected in the organ of Corti and the vestibular system from 16.5 dpc onwards, where it is most strongly expressed in hair cells (PubMed:22446089, PubMed:23528307)
+First expressed at the late blastula stage, predominantly localized to the presumptive ectoderm. Most abundantly expressed in neural tissue with more transcripts in lateral plate mesoderm than in the somites
+Expressed during the asexual blood stage, including in the schizont stage (at protein level)
+Expressed maternally and ubiquitously throughout the embryo across different developmental stages from early 8-cell stage to 24 hpf
+First detected at 7.5 dpc in the mesendoderm that forms the anterior gut and the heart. At midgestation, expressed in the limb bud ectoderm and other specialized epithelia, as well as in the branchial arches and some neural crest derivatives. In the heart, expression initiates in the myocardial plate at the presomitic stage, with highest levels in the anterior myocardium. During heart chamber formation, expressed transiently in the right ventricle, atrioventricular canal and inflow tract. In the limb bud, expression is restricted to the ventral ectodermal compartment and the apical ectodermal ridge
+Accumulates during seed development (PubMed:21457583, PubMed:9247543). In seeds, localized to the embryo tissues and to a layer of cells adjacent to the seed coat (PubMed:9247543)
+Expressed during differentiation of monocyte-derived dendritic cells (at protein level)
+In presomite and early somite stage embryos, most strongly expressed in the node and more weakly in the neuroepithelium. In 6- to 12-somite embryos, strongest expression in the node, symmetrically in the floor plate of the neural tube and in the developing heart; weaker expression in paraxial mesoderm, somites, neuroepithelium, as well as in hind- and foregut pockets. By 9.5 dpc, virtually ubiquitous
+Expressed in pstO cells, becoming more strongly expressed during culmination, and also in cells at the top of the stalk tube
+Is not detectable until stage 21, when spinal neurons begin to establish synaptic contacts with muscle cells, levels increase dramatically around stage 40
+Shows esterase activity in active, dormant, and reactivating Mtb cultures
+Expressed in cochlea on the upper surface of the spiral limbus at 16.5 dpc onwards
+Expressed at high levels in fully sporulated oocysts and merozoites. Low levels found in unsporulated oocysts. Absent in partially sporulated oocysts
+Strongly expressed in inner ear during embryogenesis
+Expression starts at the two-fold embryonic stage throughout adulthood (PubMed:7774813, PubMed:19716386). Expression increases during L2-L3, L3-L4 and L4-adult molting stages (PubMed:19716386)
+Expressed as early as 14 dpc and continues into postnatal development. Within the developing tooth, expression is localized at the apical region of the ameloblast cells and to the apical regions of the newly formed enamel matrix
+Expressed at high levels in petals from flowers at an early stage of development, and expression levels decline as the flower matures
+Specifically expressed in the tapetum cell layer and the microspores of anthers at the tetrad stage. Expression starts to decrease during pollen maturation and tapetum cell degeneration to finally disappear
+Prominent expression is observed in the central and peripheral nervous system in the embryo at Carnagie stage 17 (CS17; gestational day 42); at this stage it is also observed in the mandibular arch, cartilage primordium of the humerus, scapula, and vertebrae; in the limb expression is detected in the perichondrium. Expressed in the cerebral cortex, hippocampus, and faintly in the thalamus in fetal brain at 22 weeks of gestation,
+Expressed in etiolated seedlings
+Expressed during embryogenesis. Embryonic expression commences during cellular blastoderm formation, increases rapidly after cellularization and is maintained during the early stages of gastrulation. Expressed in larvae and pupae
+Detected from 29 days postpartum onwards, with increasing expression through to the adult stage
+Expressed in mature pollen, but not in immature pollen grains
+In the submandibular salivary gland, expression is very low in immature animals of both sexes with trace levels at 12 days of age. At 22 and 30 days of age, low levels occur in the submandibular salivary gland of both sexes with females having higher levels than males. At the onset of sexual maturity, abundantly expressed in males and undetectable in non-lactating females but is expressed in lactating females (at protein level) (PubMed:10561587). In the lacrimal gland, detectable in both sexes at 10 days of age but, by 20 days of age, expression is female-specific with no detectable expression in males (PubMed:18703064)
+Expression begins in the late blastula, peaks at stage 11 (early gastrula) and decreases thereafter
+Expressed by 16 weeks in fetal pancreas
+First detected at 3 weeks of age IN the pachytene spermatocytes. During germ cell differentiation in the adult testis, pachytene spermatocytes in stage VI of the epithelial cycle are the first germ cells to show MRP9 expression
+Expressed in the mesoderm during embryogenesis
+Expressed in G1 and peaks during the early S phase of the cell cycle
+The short isoform is present maternally while the long isoform is expressed at gastrula stages. Detected in a few cells of the Spemann organizer at the onset of gastrulation. During gastrulation expression continues in the prechordal plate and the anterior portion of the notochord anlage. Beginning at early neurula stages, expression is initiated at new sites in the head mesoderm; hypochord; pronephros; eyes; fore-, mid-, and hindbrain; and the midbrain-hindbrain junction
+In embryos, expressed in epidermal cells during the dorsal intercalation and ventral enclosure
+At 10.5 dpc expression was detected in branchial arches 1 and 2 and the fronto-nasal process, limb buds, spinal cord, and dorsal root ganglia. At 12.0 dpc expression was detected primarily in the limbs and transiently in the developing eye. By 13.5 dpc, expression in the limb was restricted to thetelencephalic region of forebrain
+Increased expression in early post-germinative growth
+Only produced in males
+First detected in the root hair zone of seedlings, mostly in the vascular bundles, cortex, and endodermis. Later observed in hypocotyls and veins of cotyledons
+Expressed during development; especially between 8 and 14 hours of development
+Detected in the newborn testis and peaks at 3 weeks during the first cycle of spermatogenesis. Expressed in the fetus and embryo
+Expressed in testis at 14 dpc and in oocytes at 18 dpc
+In premeiotic germ cells, expressed at low amounts in the antagonist form. Subsequently, during spermatogenesis, isoform 1 (activator) is generated exclusively and in extremely high amounts
+Levels increase around 8 hours of development to reach maximal levels at 16 hours and a high expression is maintained during later development
+Confined to the central region of inflorescence ane floral meristems, progressively restricted to the innermost cells of the dome. Also detected in developing stamen locules and later in sporogonous cells within locules. In carpel primordia, found in placenta and in young ovule primordia
+Very low expression in fetal brain, liver, heart, spleen and thymus
+Expressed in the skin at birth (at protein level) (PubMed:11408584). In neonatal mice, additional expression seen in the basal layer of the cornea, forestomach and esophagus (at protein level)
+At embryonic stage 15.5 dpc, expressed in the growth plate of long bones where it is mostly found in chondrocytes in the resting and proliferative zones (at protein level) (PubMed:29702220). Expression gradually increases in differentiating osteoclasts, but then decreases during the late stages of differentiation (PubMed:22492581)
+Expression is first detected in the early mid-gastrulae at the dorsal margin of the blastospore and at the anterior region of the ectoderm until the late gastrula stage. It then becomes restricted to the left anterodorsal wall of the primitive gut and to the developing left somitocoelomic system in the early neurulae stage. Expression continues on the left side in the developing preoral pit, the duct of the club-shaped gland and mouth as well as in the mesoderm at the caudal end. No expression is seen in the gland body on the right side or around the gill pores. By the mid-neurulae stage expression is detected in some cells of the central nervous system (CNS), this continues along with posterior expression in to the early larval stage. Around the rim of the mouth, expression is detected in the endoderm and ectoderm at the 36 and 48 hour larval stages. Left-sided asymmetric expression continues into the 48 hour larval stage in the preoral pit, but becomes weak or disappears in other regions
+Detected at day 11, 15 and 17 of the embryonic development. Expression increases by a factor of 2.5 at 1 week after birth. Then the expression level remains stable until the adult stage. The mRNAs for shorter forms (isoforms 9, 10 and 11) are specifically expressed in an embryo on the 11th day after gestation
+At 9.5 dpc embryos, expressed in a limited region of the neuroepithelium and also in the temporal half of the primary optic cup and the optic stalk. At 10.5 dpc, seen in the hypothalamus, temporal half of the optic stalk, and temporal hemiretina. At 12.5 dpc and 13.5 dpc a high expression is seen in regions of condensed mesenchyme of the head, and as neuroepithelial cells begin to differentiate and migrate outward from the ventricular zone, expression declines markedly. By 16.5 dpc levels are diminished and restricted to unfused pockets along the exhausted ventricular zone
+Expressed in the bloodstream form (at protein level)
+Expressed throughout embryogenesis (PubMed:19850877). At 5.5 dpc, expression is restricted to extraembryonic tissues; by 6.5 dpc, expressed in both embryonic and extraembryonic tissues (PubMed:19850877). Strong expression is observed in certain tissues including neural ectoderm, headfold and limb buds, while it is weakly expressed in the surrounding endoderm and heart (PubMed:19850877)
+Detected at very low levels in the embryonic central nervous system (PubMed:9559671, PubMed:18222039). Detected as early as 7 days post conception (PubMed:9559671). Detected in dorsal root ganglia, hippocampus, olfactory epithelia and intestine at 19 dpc (PubMed:18222039). Expression in the brain increases strongly 3-8 days after birth, a period of intense postnatal brain development (PubMed:9559671, PubMed:18222039). Detected in dentate granule cells; expression levels show no significant variability during postnatal development (PubMed:18222039). Expression is higher in adults than in neonates (PubMed:9559671, PubMed:18222039)
+Observed, in embryos from the early stage to the mature stage, with higher levels in embryo proper, and weaker signals in suspensor cells and other tissues surrounding the embryo
+Expressed in the cephalic mesenchyme, heart and paraxial mesoderm prior to 8.5 dpc. Expression is then observed in the migratory neural crest cells and their derivatives. As development progresses, expression is also observed in the limb buds and perichondrial tissue
+Rapidly degraded upon D-glucose but not L-glucose treatment (at protein level). Accumulates in leaves of plants grown under normal long daylight (16 hours)/dark (8 hours) conditions. Levels are greatly reduced in leaves from plants placed in complete darkness for 24 hours. Transcript levels return to normal within 6 hours after plants are returned to normal light levels
+In the developing nervous system, high levels expressed in both ventral and dorsal regions of the spinal cord from 13.5 dpc. Also expressed in dorsal root and cranial ganglia in 11.5-18.5 dpc embryos. Only low levels of expression in developing brain. In the developing retina (15.5 dpc), expression of E2F3 is localized to the ganglion cell layer. In other developing tissues, expressed in liver, lung and heart. Weak expression in developing kidney and skeletal muscle. Absent from the developing choroid plexus, thymus and developing skin. Low levels of expression in the developing intestinal epithelium and mesenchyme in 12.5-18.5 dpc embryos
+First expressed in 16-cell stage embryos (PubMed:19167332). Temporal expression during embryogenesis with high expression as embryos develop into 100-stage embryos, but with low expression in most cells at the comma stage and almost diminished expression at the 2-fold stage of embryogenesis (PubMed:19377305, PubMed:19167332, PubMed:21802374, PubMed:24140420). Expressed in the head, tail and intestine, especially in the anterior and posterior intestinal cells, of larvae (PubMed:19167332)
+Expressed both maternally and zygotically in all stages of development
+During ovule development, expressed in the nucellus from early stage until embryo sac maturity. In mature ovules, expressed in the nucellus and the outer integument
+Expressed in seam cells in three-fold stage embryos and during dauer larvae formation (PubMed:15936343). Not expressed in adults (PubMed:15936343)
+At 10.5 dpc is expressed in long stripes in the dorso-ventral part of the neural tube. Later at 11.5, 12.5 and 13.5 dpc expression gradually moves dorsally and medially towards the roof plate. At 11.5 dpc highly expressed in spinal cord commissural exons before crossing the floor plate. After midline crossing initially continues to be expressed but then gets down-regulated
+Mostly present in vascular tissues. In flowers, expressed in carpels, stamens and pollen
+In embryos, pupae and adults
+In larvae, predominantly expressed in subsets of neurons, including a subset of sensory neurons comprising the class IV dendritic arborization (da) neurons (nociceptors), class III da neurons and chordotonal neurons (both mechanosensors)
+Expressed in ciliated cells of the chordotonal organs, neurons of Johnston's organ and femoral chordotonal organs, olfactory sensilla on the antenna in late stage embryos and larvae
+Present throughout development
+Most abundant in anthers when the tapetum cells start to accumulate steryl-ester globules. High expression in mature leaves, medium in young leaves, and low in senescing leaves
+Localizes to the anterior cortex of the oocyte in the same region as bicoid mRNA from stage 10B/11 of oogenesis
+Present from pre-meiotic DNA replication and disappears following meiotic prophase I
+Expressed both maternally and zygotically in the embryo and throughout development
+Expressed zygotically in embryos from 0 to 12 hours after fertilization, with a peak of expression during the 2 to 4 hour period
+Expressed in post-meiotic testicular germ cells
+First expressed in the body and head at embryonic stage 3 dpc (PubMed:2153895). Expressed in the mid-thoracic region of embryos and also in the spinal cord, dorsal root and sympathetic ganglia at embryonic stage 10 dpc (PubMed:2153895). Highly expressed in the brain at embryonic stage 13 dpc (PubMed:2153895). Expressed at low levels in the gut at embryonic stage 16 dpc (PubMed:2153895). Not expressed in heart, skeletal muscle or liver at embryonic stage 16 dpc (PubMed:2153895)
+Expressed maternally. Expressed at high levels in germinal vesicle (GV) stage and MII-stage oocytes. Expressed at lower levels in one-cell embryos until 4-cell stage. Hardly detectable in morula. Expressed mainly in somatic cells from 9.5 dpc until at least 16.5 dpc. Expression in primordial germ cells is undetectable until 13.5 dpc and peaks at 16.5 dpc (PubMed:23151479)
+Expressed in hippocampal neurons at 18 dpc (PubMed:23408951). Expressed at high level both in hippocampal neurons and in brain, during the period of axon formation and elongation. Accumulates in axonal growth cones during the stage 2/3 transition. Accumulates asymmetrically in a single neurite before polarization, while it is depleted in its sibling neurites, through competitive transport to multiple neurites. Transported anterogradely to the growth cones and diffused back to the soma (at protein level) (PubMed:17030985)
+Expressed in the follicle epithelial cells throughout their development (PubMed:18331716). Not detected until the adult stage (PubMed:9813038)
+First detected in the 10 hours gastrula around the blastopore. In later stages of gastrulation and early neuralization, expressed in posterior mesoderm and the notochord where expression continues at least until swimming larval stage
+Found in shoots of non-flowering plants grown under long-day conditions at days 4 to 15, and in shoots of plants grown under short-day conditions at days 4 to 11 after germination (PubMed:19121105). Expressed in embryos from the early globular stage (PubMed:19121105). FLC is not imprinted and both parental alleles contribute equally to expression in embryos (PubMed:19121105). Expression is repressed during gametogenesis, and is then reactivated after fertilization in embryos (PubMed:19121105). In seedlings, observed in the vasculature of the cotyledons, hypocotyls, and the first pair of leaves (PubMed:18375656). Just prior to flowering, a strong reduction in expression levels occurs in the vasculature (PubMed:18375656)
+Expressed throughout development, highest expression is seen during larval development
+Expressed in larva and adult (at protein level)
+In seedlings, expressed in the root apex, mostly in the elongation zone and emerging lateral root primordia, in very young leaves and stipules. In flowers, detected from the earliest stages of flower development, before meiosis and gametogenesis and maintained later. As flower bud size reaches 1.6 to 1.7 mm, confined to male gametophytic tissues and female sporophytic tissues, including ovules. At maturity, accumulates in pollen grains within the anthers. At later postpollination stages, expressed in developing seeds. Accumulates in intracellular compartments in both sporophytic and gametophytic tissues (at protein level)
+In young seedlings, expressed in hydathodes of new emerging leaves and cotyledons as well as in columella cells (PubMed:31862580). Also observed in hypocotyl/root junction, hypocotyls and in root apex (PubMed:31862580)
+First detected 9.5 dpc in one-third of developing somites. At 10.5 dpc, expressed in the myotome compartment of somites. At later stages of development, detected in a wide range of developing muscles. Expression continues in adulthood
+Expressed both maternally and zygotically. Zygotic expression is initiated before gastrulation and persists through to day 5 of development. Levels increase in late somitogenesis, and late embryonic and early larval stages. Embryonic expression is observed in many developing tissues and organs, including the notochord and brain, and heart and vasculature. Detected throughout the lens at 24 hours post-fertilization (hpf), but by 3-4 days development, restricted to the lateral epithelium and differentiating cells in the equatorial region
+BPP-10a, BPP-10c+QQWA, BPP-AP, BPP-13A, BPP-13a+QWA and BPP-13a+QQWA seem to be found in both adult and newborn B.jararaca venoms, whereas BPP-APL seem to be only present in newborn venom
+Expressed in the hypodermal cells of the tail and head, the seam cells, and in the hyp7 syncytial hypodermis in the mid- to late-larval L4 stage, and young adult (PubMed:24569038, PubMed:29604168). Not expressed in the cells of the developing vulva (PubMed:24569038)
+Earliest isoform to be expressed during embryogenesis in cells of embryonic origin at 7 and 9.5 dpc, and is the major isoform expressed in uterine tissue at the time of implantation (4.5 dpc) and continues to be expressed in uterine tissue at 6.5, 7.5 and 9.5 dpc. It is expressed in giant trophoblasts at 9.5 dpc and is expressed in the placenta through 15.5 dpc
+Placental lactogen II is expressed from days 12 to term of pregnancy
+Found in etioplastic PSII (i.e. before PSII is fully assembled and functional)
+Expressed in spermatogonia and in primary spermatocytes up to late pachytene stage (at protein level)
+Expressed during spermatogenesis in stage-synchronized testes
+Expressed both maternally and zygotically. Zygotic expression persists into the pharyngula stage
+Widely but not homogeneously expressed in developing nervous system. Expression levels in mammary glands are barely detectable in virgin mice, levels increase during pregnancy, reaching a maximum during late pregnancy, then decrease during lactation becoming very low post-lactation
+In root trichoblasts, accumulates into patches at the basal end of the cell before a hair bulge is visible and remain concentrated at the tip of the bulge and in the growing hair
+Transcribed in low amounts by sigma-F. Transcribed during stage III of sporogenesis by sigma-G
+Expressed in the ectoderm at 7.5 dpc and within the germ cell layers at 8.5 dpc. Expressed within the neural epithelium and the neural tube at 9.5 dpc and subsequently expressed in the nervous system throughout development. Expression in the proliferative zones of the central nervous system declines between 14.5 dpc and 16.5 dpc, while expression remains high in the cerebral cortex and the neural retina. Expressed in the pituitary and the sensory epithelia throughout development
+Expressed in embryo from stage-5 onwards. Expressed in larvae
+Expressed both maternally and zygotically, with zygotic expression continuing to the tadpole stage (stage 42)
+Expressed in the endosperm of embryo from the two nuclei stage to the late globular embryo stage, including the endosperm cellularization time
+Expressed throughout development. Localized to discrete structures during neurulation. The pattern of expression is increasingly refined to include the head, central nervous system and tissues along the dorsal midline to the tailbud
+Expressed throughout the cell cycle. Expression peaks at the G1/S phase boundary and declines during S phase
+Expressed in pancreatic alpha-cells at 10.5 dpc (PubMed:17901057). Expressed in insulin and glucagon islet progenitor cells at 12 dpc onwards (at protein level) (PubMed:16443760). Detectable at 8.0 dpc (one somite) as a band in the caudal hindbrain and by 8.5 dpc (six to eight somites) as a sharp rostral edge coincident with the rhombomeres (r) 4 and 5 boundary and a diffuse caudal edge located midway through r6 (PubMed:8001130). Expressed in the lens epithelial cells at 10.5 to 14.5 dpc (PubMed:10383433). Expressed in the cochlear nucleus at 15.5 dpc (PubMed:17977745)
+Barely detected in the heart at 15.5 dpc, but clearly expressed in newborn heart with increased amount up to 8 weeks of age
+Highly expressed in the S and G2 phases and reduceed levels in the M phase
+Expressed both maternally and zygotically. Levels are constant from stage VI oocytes to the end of blastulation, decreasing at the onset of gastrulation and becoming undetectable at later stages
+Expressed throughout embryonic development, but rarely expressed in lineages that do not produce neurons (PubMed:31386623). First expressed in neural precursors at the mid-gastrula stage of embryogenesis (PubMed:31386623). Highly expressed during the late gastrula to lima-bean embryonic stages, but weakly expressed in subsequent embryonic stages (PubMed:31386623). Post hatching, expressed in few neuronal nuclei and transiently expressed in postembryonic neuroectoblasts (PubMed:31386623). Not expressed in postmitotic neurons (PubMed:31386623). In L1 larvae, expressed in neurons and glia, but not in non-neuronal precursors (PubMed:31386623). In L2 stage larvae, expressed in the rectal epithelial Y cell (PubMed:31386623)
+Expressed during the asexual blood stage, specifically during the trophozoite and schizont stages (at protein level) (PubMed:18397290, PubMed:22379140). Not detected at the ring stage (PubMed:18397290)
+Expressed both maternally and zygotically. Although many papers suggest that Xenopus survivins are not expressed in adults, PubMed:16759290 reports an increase in expression during metamorphosis, and expression in multiple adult tissues
+Expressed to a high level in young floral buds, but decreases in the later floral developmental stages. Expression restricted to microspores and pollen grains at the later developmental stages of anther
+Accumulates in fruits when berries are small and hard green until complete ripening
+Expressed during embryogenesis. Already detected in the 8-cell stage at the inner cell boundaries. Later, polarity is gradually established at the basal side of provascular cells then in epidermis cells
+Senescent tissues specific expression
+Expressed at day 18 dpc in embryonic brain
+Expression is elevated in proliferating cells and down-regulated in cells undergoing growth arrest. During the cell cycle, expression is low in G1-arrested cells, increases during S phase and remains high at G2-M phase
+Isoform A is expressed in all developmental stages with highest levels in young embryos and adults. Isoform B is detected only in adult head
+Expressed strongly in embryos and L1 larvae, but severely reduced or absent in later larval and adult stages (at the protein level) (PubMed:11018015). Expressed widely in embryogenesis, including ABp(l/r)aapapp cells, which are precursors to the AIB interneurons and the ASI chemosensory neurons, hypodermal cells hyp4, hyp5, hyp6, hyp7, H0, H1, and ABp(l/r)aapapa cells, which give rise to the AWA and ASG sensory neurons (at the protein level) (PubMed:11018015). Expression in the postembryonic M lineage is asymmetric; beginning at the 8-M stage and continuing through the 18-M stage, expressed in all the ventral, but not dorsal, M lineage cells (PubMed:29155044). Expressed dynamically during embryogenesis in head hypodermal cells, as well as in ventral body wall muscle (BWM) and intestinal precursor cells (PubMed:11018016, PubMed:27341757). Expression not detected in any dorsal BWM or its precursor during embryogenesis (PubMed:27341757)
+Broadly expressed in neuronal, intestinal and in hypodermal cells, including hyp7 cells, throughout the larval stages and persisting into adulthood
+Expressed maternally. Expressed in the earliest stages of oocytes, and accumulates during oogenesis. Also present in early embryos with expression declining rapidly after the onset of zygotic transcription at the mid-blastula transition (MBT). Although PubMed:12454937 conclude that, with the exception of the ovary, expression is absent in adults, PubMed:16759290 suggest that expression is adult-specific and is absent in embryonic and tadpole stages between gastrulation and metamorphosis
+First detectable at low levels at the late gastrula/early neurula embryo (stage 14). Levels remain approximately constant throughout subsequent embryonic development, before declining in the tadpole
+Expression begins early in embryogenesis and continues in larval development and into adulthood of males and hermaphrodites
+Highly expressed in the retinal pigment epithelium (RPE)/ choroid of the 21 dpc embryos (at protein level)
+Accumulates in tissues undergoing senescence and abscission
+At 10.5 dpc, expressed in forelimb and hindlimb buds, in the distal mesenchyme below the apical ectodermal ridge. At 11.5 dpc, expression is restricted to the subridge mesenchymal layer, as well as in the dorsal and ventral regions of the developing limbs
+Not detected in ovaries from neonates. First detected in ovaries three days after birth, and expression in ovaries increases dramatically to reach a much higher level eight days after birth
+Expression limited to early pregnancy with abundant expression on day 7, slightly declining expression on day 9, and no detectable expression by day 11
+Has two phases of temporal expression during embryogenesis; first expressed at late blastula (stage 9) with expression peaking at early gastrula. Expression then disappears before restarting in a second phase in late neurulae (stage 17)
+Expressed in P2 cell of 4-cell stage embryo (at protein level) (PubMed:11441002). At the comma stage, expressed in cells in the lateral sides (at protein level) (PubMed:11441002). Specifically expressed in intestine from the 2-fold embryonic stage onwards including in the larval and adult stages (at protein level) (PubMed:11441002, PubMed:19741196)
+Expressed throughout all stages of the cell cycle (at protein level) (PubMed:21311225). Expressed throughout development with notably less expression in third instar larva than in embryo or adult (PubMed:18286205)
+Expressed in the retina at a higher level than that in the brain at all developmental stages and this high level of expression in the retina is detectable much earlier than that in the brain (at protein level)
+Expression begins in early gastrula stage embryos, peaks at the mid-gastrula stage and remains detectable until late tailbud
+At the blastula stage, expressed within the vegetal pole domain and throughout the cells fated to become the endomesoderm. By mid-gastrula, expressed throughout the archenteron, with some clearing evident at the tip of the mesodermal bulb. Expressed at the larvae spines
+Detected in male and female third instar larvae with very low levels detected in adults (at protein level)
+Is detected in unfertilized eggs, late planulae, primary polyps and adult females (but not males) (at protein level)
+Expression is highest in fetal brain at 16 dpc with decreased levels as development progresses. By postnatal day 3 detected in hippocampal pyrimidal neurons and cortical neurons
+Abundant after 6-12 hours of growth. It is not significantly expressed after 24 hours, which is several hours after entering the stationary phase of growth
+Expression begins during the period of stratification at 15.5 dpc, increases up to 17.5 dpc and decreases at 18.5 dpc
+Highly expressed in newly emerged larvae at second, third, fourth and fifth instar stages (PubMed:24473143, PubMed:30987273). Has lower expression during the molting phases of larval development (PubMed:24473143, PubMed:30987273). No expression detected during pupal stages (PubMed:24473143, PubMed:30987273)
+ApoII mRNA induction by estrogen in kidney at day 11 is at 10% of the level in the liver but estrogen-responsiveness decreases later in development and is low in the adult
+Alpha-7 transcripts transiently accumulate in the developing optic tectum between 5 dpc and 16 dpc
+In presumptive cardiac ventral mesoderm at the time that bilateral progenitors fuse and form the cardiac tube. By stage 30, expressed in the developing atria and ventricles; at stage 38, in endocardial layer. By stage 40, detected in the great vessels
+Induced during differentiation of primary preadipocytes to adipocytes. Expression increased from fetal to adult in retinal pigment epithelium
+Expressed in prestalk pstO cells but not in pstA cells. Strongly expressed throughout development. Expressed normally in dmtA-null cells
+Developmentally regulated (PubMed:9195912). PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development (PubMed:9195912). It persists strongly only in adult skeletal muscle (PubMed:9195912)
+During parasite asexual blood stages, expressed at the late schizont stage and in free merozoites (at protein level)
+First detected at 11.5 hours post-fertilization (hpf) in dorsal presomitic mesoderm and in the neural keel, extending to the ventral somitic mesoderm during tail budding. At 16-19 hpf, the rostral expression boundary is at somite 10. By the end of somitogenesis, expression decreases in the lateral and ventral mesoderm and becomes restricted to the neural rod. Also expressed in the developing pectoral fins from 34 hpf, with progressive localization to the periphery
+Isoforms 1 and 2 are expressed in embryo, larva and adult while isoform 3 is expressed only in embryo
+Highly expressed in male embryonic germ cells at embryonic day 16.5 and expression decreases by postnatal day 2.5
+Ubiquitously expressed at low level in 12.5 dpc and 15.5 dpc embryos. More significantly expressed in the nervous system at 12.5 dpc and the cortical plate at 15.5 dpc. Expressed in the brain postnatally in particular in the hippocampal formation and the medial habenular nuclei at P7. Low-level expression in other brain areas was present at P7 and was reduced to very low levels at P14 and P21. The hippocampal granule cell layer and the cerebellar granular layer maintained moderate expression levels at P7, P14, and P21
+First expressed at the cellular blastoderm stage and continues to be expressed through subsequent development
+Expressed in the jejunum in 13-14 days old animals (at protein level) (PubMed:12620923). Expressed in the kidney in 13-14 days old animals (PubMed:12620923)
+FERT-1 transcripts are produced in the precursors of the gametes, but degraded at the time of meiosis and not passed on to the zygote
+In the developing limb bud, the protein is expressed in the apical ectodermal ridge and the mesenchymal compartment, predominantly in the posterior region. During kidney morphogenesis, expression is initially restricted to the epithelial compartment of the pronephros and mesonephros
+expressed ubiquitously at early stages of development. Expressed in the endocardial cells lining the ventricles and atria at 9.5 dpc
+Highly expressed in the trichomes of emerging leaves (PubMed:29258424). Observed in flower stigma (PubMed:29258424)
+Has low expression in pericytes and adventitial vascular cells (ASC) derived from adipose tissue. Highly expressed in differentiating mesenchymal stem cells derived from pericytes and ASC
+Expressed in ameloblasts as they undergo post-secretory transition. Expression decreases as ameloblasts progress through maturation
+Expressed in dry seeds and germinating seeds until 4 days after soaking (at protein level)
+Expression increases during embryonic development
+In the embryonic gonads it is expressed as early as 13.5 dpc and later. In 3-day-old postnatal ovaries, it is expressed within oocytes in germ cell clusters and primordial follicles. In the adult, it is expressed only in small follicles, primary primordial and primary follicles. In testis, it is exclusively present in spermatogonia. Present at postnatal day 5, when spermatogonia stem cells differentiate into type A spermatogonia. Absent in Sertoli cells or spermatocytes (at protein level). Expressed in the germline as early as 12.5 dpc and precedes SOHLH1 protein expression, which occurred circa 15.5 dpc. SOHLH1 appearance at 15.5 dpc correlates with SOHLH2 translocation from the cytoplasm into the nucleus (PubMed:28504655)
+Expressed in extraembryonic tissues and placenta at 11.5 and 18.5 dpc (at protein level). Expression continues throughout gestation and is strong in adult lung (at protein level)
+To initiate infection, trophozoites emerge from a cyst in the host. Excystation is blocked by specific cysteine protease inhibitors. Vacuoles release it just prior to excystation. Expressed in replicating and encysting trophozoites without supplemental iron
+Expressed in late throphozoide to schizonts and in merozoites (at protein level)
+Expressed in intestine, pharynx, and hypodermis at larval stage L4
+In the developing brain, selectively expressed as early as postnatal day 7-10 in cerebellar granule cells
+Expressed in the developing cochlea
+Expressed at maximal level at 12 dpc. Declines progressively until birth
+In flowers, highest levels of mRNA are found in closed capitula and amount decreases during floral development, detected at protein level in both closed and open flowers. At the mRNA level, virtually undetectable in seeds at all stages. At protein level, detected in the embryo during the first stages after seed hydration, levels gradually decrease and it becomes almost undetectable after 72-84 hours
+Expression in fetus is maximal at term and declines postnatally
+Expressed in different stages of embryogenesis, from 7.5 dpc through 14.5 dpc. The highest levels of expression is found in the visceral endoderm at 7.5 dpc and 8.5 dpc and in the fetal liver at 12.5 dpc and 14.5 dpc
+Highly expressed during the first days following germination and then decreases in the later growth stages
+In both quiescent and germinating seeds
+Appears in the embryonic ectoderm during gastrulation when epidermal differentiation commences and it disappears from the neural plate aera upon neural induction
+Expression is first detected during late embryogenesis, at stage 15 in the dorsal trunk. At stage 16, expression is observed in the TC and extends into the primary branches. By stage 17, expression is more extensive in the primary branches and in some secondary branches
+Expressed in developing tectum (at protein level)
+In flowers, accumulates in stamen filaments as well as in the apices and bases of juvenile and elongating siliques. Present in leaf primordia
+Present in the whole roots
+Expressed in meiotically incompetent oocytes. Expression increases in fully grown meiotically competent oocytes. Expression then decreases during metaphase-II arrested eggs, one-cell embryo, two-cell embryo and eight-cell embryo stages, and increases again during blastocyst stage
+Highly expressed in 0-5 hours embryos and in adult females, suggesting that it is expressed maternally
+Mostly expressed in actively proliferating tissues
+Expression increases during skeletal muscle cell differentiation followed by a decrease at later stages of differentiation
+In the embryo, expression increases dramatically between 14.5 dpc and 18.5 dpc (at protein level)
+In 8 week-old embryo, expressed in brain, tongue, heart, liver, lung and vertebrae
+The levels of dTMP kinase mRNA and its enzymatic activity fluctuate during the cell cycle, peaking at the S phase
+Expressed at higher levels during the embryonic and pupal stages of development. Expressed in proliferating tissues of the presumptive mesoderm in stage 7 gastrulating embryos. Expressed in the mesectoderm and anterior and posterior midgut primordia of stage 9 embryos. Also expressed in proliferating cells of the central nervous system during germ-band retraction
+Rapid decrease in roots and leaves from the leaf opened to the green fruit stage (PubMed:30577538). At the leaf opened stage, accumulates mostly in leaves (PubMed:30577538)
+Levels increase steadily between 1 week and 6 months after birth and decrease slightly between 6 months and 15 months after birth
+Expressed constitutively in all life-cycle stages examined
+Initiates at the cellular blastoderm stage in distinct bilateral domains within the procephalic neuroectoderm. Present in narrow stripes that cover dorsolateral positions at about 75% egg length. During gastrulation, a second bilateral pair appears posteriorly to the initial domains, from which they are separated by a 3 to 4 cell wide gap. During germ band elongation, both the primary and secondary domains of expression become wedge-shaped. During stage 9, a third pair of bilateral domains appears anteriorly to the primary domains. The 3 domains of expression may reflect the proposed subdivision of the protocerebral primordium into an anterior, central, and posterior/optic lobe domain, respectively. The existence of gaps between the domains of expression suggests that it marks only a subset of cells within each of the 3 protocerebral primordia. Following stage 9, neuroblasts segregate from the domains and the central and posterior domains split into smaller subdomains. During later events of brain morphogenesis, the presence of 3 domains of expression can still be discerned, and prominent expression in late stage embryos include the optic lobe region. At late stage 11, it is also expressed in the ventral neuroectoderm, where it appears in a small cluster of neuronal precursors within each hemisegment
+Expression elevated at 11 dpc when the branchial arches and facial swellings are present
+Present in uninucleate microspore and bicellular pollen
+Widely and highly expressed during the first 3 days of embryogenesis. Prominent sites of expression are the eyes and optic tectum on day 1, the fin buds, liver primordium, and gut on day 2, and the branchial arches on day 3
+In the larva, becomes detectable at the late second larval instar stage and continues to be expressed throughout the larval period
+Expression in the asymmetric and ventral D motor neurons in the ventral nerve cord is restricted to the postembryonic stages L2 and L3
+Between 10 dpc and 12 dpc, abundantly expressed in neuroepithelium, branchial arches, cranial nerves, liver, heart and spinal ganglia
+In non-inoculated roots, present in root hair cells of lateral roots and fades out in older regions of roots (PubMed:16844829). In young roots, localized at high levels in both epidermis and cortical layers (PubMed:22874912). Associates with primordium formation and with infection throughout the nodulation process. First day after inoculation by S.meliloti, restricted to discrete areas of root epidermis. During the second day, observed in the inner cortex, in regions where cell divisions lead to the formation of nodule primordia and in the middle cortex of regions where root hairs undergo root hair curling (PubMed:16844829). After three to four days, detected in outer cortical cells directly underlying infected root hairs and through which infection threads occur. Weak levels remain in the epidermis (PubMed:16844829, PubMed:22874912). After five days, highly expressed in the central nodule tissue of young, emerging nodules characterized by a highly ramified infection thread network (PubMed:16844829). In mature nodules, restricted to the infection zone, and, at low levels, in interzone II/III, but excluded from the nitrogen-fixing zone (PubMed:16844829, PubMed:22874912). Localized on infection threads before rhizobia are released (PubMed:25351493, PubMed:16844829)
+In the testis, expressed in spermatocytes and elongating spermatids
+Expressed during the asexual blood stage; expression begins in rings and peaks in schizonts and merozoites (at protein level) (PubMed:16321976, PubMed:16513191, PubMed:16750579, PubMed:19576251, PubMed:20070315, PubMed:21239623, PubMed:23332154). Expressed in gametocytes (at protein level) (PubMed:23332154). Expressed in the zygote at the early stages (at protein level) (PubMed:23332154)
+Detected at 6.5 dpc in the boundary between the extraembryonic and embryonic regions. At 8.5 dpc, weakly expressed in the future gut, allantois, yolk sac endoderm and the ectoplacental cone. At 9.5 dpc, strong expression in the primordial gut and presumptive fetal liver, in the floorplate of the myelencephalon, neural crest cells, spongiotrophoblasts, and giant cells of the placenta. At 12.5 dpc, detected in hepotocytes, in the outflow tract of the heart in a specific subset of dorsal root ganglia, in the cranial nerve ganglia, in the lung primordium, and in the epithelium of the expiratory tract. In newborn, strongly expressed in keratinocytes, in the cartilage, in bronchial epithelia, and bone membrane
+Widely and transiently expressed by immature neurons, appearing around the time of final mitosis and disappearing after cell migration and axon outgrowth have been completed
+First detected at very low levels at embryonic day 6. Detected at embryonic day 9 and 14, and 3 days after hatching
+Expressed in all developmental stages, with highest expression in the egg, probably of maternal origin. Very low expression in the early larva, rising through larval development up to the third larval stage. Constant expression in the pupa and adult
+Expressed in rhombomeres 3 and 5 during early hindbrain development and in the floor of the foregut pocket. Also expressed in the early Rathke pouch, derived adenohypophysis, and developing inner ear. During later embryogenesis, strongly expressed in the major part of the central and peripheral nervous system
+Expressed in seeds from 2 to 6 days after imbibition
+Expressed during ovules and embryo development
+Specifically expressed in differentiated neurons, but absent from proliferating neural stem cells
+Expressed in tachyzoites and bradyzoites; expression increases following the tachyzoite to bradyzoite conversion (at protein level)
+Expressed 7.5 hours after induction of meiosis
+Expressed during early development stages (12.5 dpc, 13.5 dpc, and 14.5 dpc)
+Expressed from postnatal day (PND) 7 and peaks in adult
+Expressed throughout development with high levels in larva and pupa
+Expression coincides with the increasing numbers of round spermatids and decreases during the termination of the first spermatogenic cycle
+Up-regulated at the time of mucilage production during seed coat differentiation
+Levels in the medial basal hypothalamus and preoptic area are elevated during neonatal life (1 week-6 months), decrease during juvenile development (8-18 months) and markedly increase during the expected time of puberty (30-36 months)
+Highly expressed throughout embryogenesis, from fertilization to hatching. Detected in embryonic neuronal tissues, including forebrain, hindbrain, spinal cord and retina
+Expression increases in prefrontal cortex from 6 months to, at least, 39 months
+Required for nitrogen fixation in root nodules on soybeans, but not for aerobic growth. It seems to be expressed under many growth conditions (aerobic, microaerobic and in nodule bacteroids)
+Expressed late in ontogeny
+In larvae, expressed in the NSM serotonergic neuron and in muscles
+Up-regulated during fruit ripening
+Expressed throughout development in all embryonic stages analyzed, 10.5 days post coitum (dpc) to 18.5 dpc. In 16.5 dpc embryos highly expressed in skin, lung, thymus, duodenum and the ependymal cell layer surrounding the ventricles in brain. Highly expressed also in the salivary glands, tongue, vibrissae, choroid plexus, blood vessel walls, esophagus and midgut. Low expression levels in spinal cord, heart and liver
+Expressed at late stages of coral development (late planula, polyps, and adults), in ectodermal cells
+Increase of expression in pollen during flower development. Expressed in developing leaves, sepals, petals, stamens and carpels
+Restricted to the prespore compartment of sporulating cells
+Is highly detected in planulae and primary polyps (9d), and more weakly in both adult females and males (at protein level) (PubMed:33060291). Transcripts are abundant in larvae and significantly decrease later in the life cycle (PubMed:29739837)
+Expressed throughout development, with the highest levels occurring during late larval stages, then falling drastically during pupariation
+Strong expression confined to the embryonic stages
+First expressed at the mid-neurula stage (stage 16) and remains at a constant level until the tadpole stage
+Expressed at HH stage-10, with a restricted expression to the caudal notochord expanding between Hensen node and the last individualized somite. No expression in the ventral midline of the neural plate. The regionalized expression in the notochord persists at least until HH-stage 15. At HH stage-13, expression can be observed in the roof of the caudal diencephalon and expands, at HH stage-15, caudally to the mesencephalon
+Expressed in notochord from 18-24 hours post-fertilization (hpf) and prominently in brain and swim bladder from 3 days post-fertilization (dpf)
+Strongly expressed in anterior neural plate at 8.5 dpc, followed in optic sulci and ventral forebrain at 9.0 dpc, and in eye at 10.5 dpc uniformly expressed in neuroretina at 15.5 dpc, and at later stages, expression decreases
+Specifically expressed in the endothelium of the developing blood vessels in embryos
+Highly expressed during spermiogenesis
+Present at all stages, but reaches the highest levels during early to mid-embryogenesis. Isoform cytoplasmic is the predominant one from the cellular blastoderm stage until germ-band retraction. Isoform neural is first seen after germ band retraction
+Strong expression in embryos. Maximally expressed in brain during embryonic development but declined thereafter
+During oogenesis and early development
+Levels increase throughout adipogenesis
+Expressed preferentially in the bradyzoite stage
+Expressed in ovary, embryo, spleen, thymus, brain, kidney, epididymis, heart and liver at 14 dpc and in oocytes at 18 dpc
+Ubiquitous in young leaves primordia. Becomes more prominent in developing trichome cells but disappears progressively when trichomes begin to initiate branches
+In embryo, expressed as early as the four-cell stage and continue to accumulate in morulae and blastocysts (at protein level) (PubMed:30111536). Expressed in growing oocytes with the nonsurrounded nucleolus configuration, reaches a peak in oocytes within pre-antral and early antral follicles and nearly disappears in the fully grown oocyte with the surrounded nucleolus configuration (PubMed:30283081)
+At 4 days-post-fertilization (dpf), expressed in the inner and outer plexiform layers of the retina, the marginal zone of the tegmentum, the developing craniofacial cartilage and in the ventral spinal cord
+Starts to accumulate in 7-10 days old plant leaves
+Expression detected at postnatal day 7 and expression increases until 4 weeks after birth
+Expressed in the embryo at the globular stage and in endosperm nuclei and chalazal endosperm of developing seeds
+Expressed in late pupal and adult stages
+Expressed a low levels in pancreas at birth, expression increases through the suckling-weanling period to reach adult levels by the time of weaning
+In summer, present at higher levels in older needles and twigs than in tissues from the current year. In winter, detected at high levels in both older and current-year needles and twigs
+At 9.5 dpc, expressed at significant levels in cardiac muscle with lower levels detected in skeletal muscle of tongue. At 15.5 dpc, cardiac expression is down-regulated and only weakly detected in atria, whereas skeletal muscle expression is more robust
+Higher expression in early embryo than in adult
+Expressed in immature intermediate neural progenitors (INP) and type II neuroblasts in larval brains (at protein level) (PubMed:24550111, PubMed:27151950, PubMed:27510969, PubMed:28245922). Expressed in lamina L3 neurons from early pupal to adult stages, but is absent in late third instar larvae when lamina neurons begin to differentiate (at protein level) (PubMed:29513217). Expressed in the developing embryonic brain from stage 4 (PubMed:18621688)
+The wetA gene is activated only during conidiophore development, and its mRNA accumulates preferentially in mature conidia
+During the asexual blood stage, expression is low in rings, increases in trophozoites to reach a peak in schizonts (at protein level)
+Low expression in vegetative and flower stages. No expression in young siliques but highly expressed in older siliques
+Expressed both maternally and zygotically. Expressed at a low level in unfertilized eggs with increased expression during late gastrula through neurula and tailbud stages
+Very low levels in stage I oocytes, gradually increasing throughout oogenesis. Further increase is achieved during early embryogenesis
+Expression is low in embryonic brains (12 dpc to 16 dpc) but increases dramatically after birth (postnatal days P0-P3) and reaches a plateau during the period when most synapses are formed (P5-P8)
+Down-regulated during the development of brain
+Accumulates in root cells that are adjacent to intra-radical fungal hyphae or in cells that harbor them during arbuscular mycorrhizal (AM) symbiosis, especially in epidermal and cortical cells
+Maternally expressed from the 4-cell stage and ubiquitously expressed through early embryogenesis, with enriched expression in the brain region at 36 hpf (hours post fertilization)
+First observed in very early stages of seedling development. Particularly expressed in the vascular tissues and the petioles
+Expressed at an early stage of pancreas development, shortly after the onset of endodermal budding that forms the pancreatic anlage. In 9.5 dpc embryo, expression is in the myelencephalon and the neural tube at the cervical level. In the 10.5 dpc embryo expression expands as a thin stripe to the posterior end of the neural tube. The central nervous system anterior to the myelencephalon is devoid of expression at this stage. In 12-12.5 dpc embryo, expression expands anteriorly to the cerebellum region. During retinogenesis, restricted to postmitotic neuronal precursor population in the ventricular zone of the developing retina. Not expressed before 12.5 dpc when is detected in the central region of the retina. By 14.5, expands from the center to the entire retina. Between 16.5 dpc and P1, continues to be expressed strongly in a subset of cells within the outer neuroblastic layer. Expression begins to be down-regulated by P2 and is undetectable in retinas from P6
+At early stages of embryogenesis, the polycistronic RNA is expressed in seven segmentally separated blastoderm stripes and in a cluster of cells in the anterior part of the embryo (PubMed:17439302). By stage 13 to the end of embryo development, it is expressed in the dorsal trunks, posterior spiracles, pharynx, hindgut and the area which forms the denticle belts (PubMed:17439302). In the leg disk, it is expressed in a ring pattern presumed to be developing tarsal region around 80 to 96 h after egg laying (AEL) and then in the tarsal furrow at the mid-third instar larval stage (PubMed:17439302, PubMed:18801356). Not detected in the tarsal primordium after 100h AEL but is still expressed in a dorsal chordotonal organ of the leg disk (PubMed:17439302). In pupae, expressed broadly throughout the leg disk 0-3 h after puparium formation (APF) but is not detected in this region 6h APF (PubMed:25344753). High expression 4-8 h APF in the presumptive joints between tarsal segments (PubMed:21682860). In the noctum expressed from 40 to 44 h APF (PubMed:25344753). In wing disks of third stage larvae, expressed in two anterior stripes and later in the precursors for chemosensory organs (PubMed:21682860). From late third stage instar larvae to early pupal stages, it is also expressed in the wing provein cells that develop into longitudinal veins L2-L5 (PubMed:21682860). In eye disks, expressed in preclusters for presumptive R8 photoreceptors and in a stripe of cells in the posterior region of the disk (PubMed:21682860)
+During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells. In hindleg muscle, first expressed at 15 dpc after which, levels increase sharply between 15 dpc and 17 dpc. A steep prenatal rise in expression accompanies the formation of secondary myofibers and the development of innervation. High levels continue throughout newborn and adult stages. Beginning at postnatal day 5, a second sharp increase in expression correlates with the definitive specialization of the myofibers. Later in development, mainly expressed in fast-twitch fibers. In cardiac muscle, first expressed in the embryo in the cardiac tube
+Expressed during embryogenesis at the globular stage on the apical flanks of the embryo, where the cotyledons are subsequently formed. Expression in the cotyledons persists at the heart stage until the mid-torpedo stage. At the bent-cotyledon stage, expressed weakly in the apical meristem. At the early phase of flowering, expressed in discrete groups of cells on the flanks of the apex initially marking the floral anlagen. During primordia differentiation, expressed in the adaxial portion of the primordia. In developing flowers, transiently expressed in nascent floral organs and then decreases as floral organs mature
+Expressed at significantly higher levels during hibernation and post-breeding. Not expressed in pituitary
+Expressed at constant levels in the oocyte and early embryo
+Present most strongly at early stages of oogenesis, in germ cells in the germarium. Present in germ stem cells and dividing germline cyst cells. Weakly or not expressed in somatic cells at the tip of the germarium, including the terminal filament, inner sheath cells, or cap cells, but it is present at low levels in somatic cells in regions 2 and 3 of the germarium, including the prefollicular cells and the follicle cells of stage 1 egg chambers. Soon after egg chambers budd off the germarium, levels increase in the follicle cells. By mid-oogenesis it decreases in the nurse cells, while levels continued to increase in the follicle cells (at protein level)
+First detectable in the inner cell layer of the embryonic shield during gastrulation. By 9.5 hours of development, expressed in a continuous band that extends from the tail to the head, the anterior boundary of expression being positioned in the center of the animal pole anterior to the presumptive midbrain
+Concentration of E6 is highest during the late primary cell wall and early cell wall synthesis stages
+Accumulates late in pollen development and/or during germination and tube growth
+In the developing tooth, initial expression observed in odontoblasts at all stages of development. At later stages, restricted expression pattern in ameloblasts. Also observed in osteoblasts in the alveolar bone
+Significantly expressed throughout all stages of growth or development
+Expressed in pre-comma stage embryos, and in particular in hyp7 hypodermal precursor cells
+Expressed in the brain at low levels during fetal development, from 13.5 dpc to 18.5 dpc, however significantly increased after birth from P1 to P60 (PubMed:33115731). Highly expressed in neural stem progenitor cells in the hippocampus after birth (PubMed:33115731)
+Expressed in growing oocytes but diminishes in fully grown oocytes (PubMed:18057100). Detected at very low levels in morula and early blastocyst (PubMed:18057100)
+Expressed in growing oocytes, ovulated eggs and preimplantation embryos up to the morula stage and decreases markedly at the blastocyst stage (at protein level)
+Up-regulated during postnatal development, and expressed in adult stage
+Expressed predominantly in the lung and brain during embryogenesis. Expressed in the lung epithelium and the mesenchyme immediately adjacent to the epithelium from 10.5 dpc. At 9.5 dpc, expressed in the foregut endoderm but not in the heart. At 16.5 and 18.5 dpc, expressed in both the proximal and distal airway epithelium. Also expressed in the developing gut. In the hindgut, primarily expressed in epithelial cells of the intestine and stomach. Expressed in the brain in a dynamic pattern. At 14.5 dpc, expressed at high levels in the intermediate zone of the neopallial cortex with lower levels in the surrounding cells. By 16.5 dpc, no longer expressed in the intermediate zone, but still present in the surrounding cells of the neopallial cortex
+Highly expressed in the brain of embryonic mice. Expression levels gradually increase from 10 dpc to postnatal day 10 (P10) (at protein level)
+Strongly up-regulated in differentiating fetal muscle cells (in vitro)
+Expressed in brain. Very low expression in lung and liver
+Appears first at 3 hours post-infection, increases to give the strongest signal at about 9 hours and gradually wanes to almost nothing at 24 hours
+Not expressed in vegetative cells. Expression is apparent by 8 hours and peaked by 16 hours. Becomes present during aggregation and throughout development
+In early embryo and during organ development
+Highly expressed during logarithmic phase of growth. Down-regulated during the stationary phase
+Expression peaks in late G2/S phase of the cell cycle
+No expression in eggs nor day 1 pupae, yet it is readily detectable in larvae and adults
+Specifically expressed in the forespore under the control of the sigma-K factor
+Expressed throughout embryonic development with highest levels at 8.5 dpc. Expression decreases by 11.5 dpc and increases again by 17.5 dpc
+Expressed in germinal vesicle oocyte, metaphase II oocyte and blastocyst (at protein level). Expressed in oocyte
+Tightly regulated during anther development
+Expressed in heart at embryonic day 12 and 14 (at protein level). Expressed in heart at embryonic day 8
+Detected at all developmental stages
+Expressed in ependymal cells of the embryonic brain, but almost absent in the adult brain
+Develpomentally regulated, with the highest expression in flowers and immature siliques
+Isoform A: Enriched in germ plasm but is degraded in pole cells immediately after pole cell formation. Isoform D: Enriched in germ plasm, partitions into pole cells and remains detectable in pole cells until they migrate through the midgut epithelium toward the overlying mesoderm
+Expressed in vitellogenic oocytes, ovulated eggs, and in ovarian follicle cells (PubMed:32973303). Highly expressed in early-mid vitellogenic oocytes and significantly lower in full grown oocytes and ovulated eggs (PubMed:32973303)
+Not detected in testis until 18 days postpartum. At 22 days postpartum, levels increase and remain constant during adulthood. During spermatogenesis, expressed from pachytene spermatocytes to mature sperm
+First detected in the female fat body on day-2 of spinning stage, reaching maximal levels at larval-pupal ecdysis and declining thereafter. Not found in the male tissues
+Expressed in a cell cycle-dependent manner. Low expression at the G1/S transition and increases during the S phase. S/G2 transitions
+Expressed at higher level in embryos than in L1 larvae
+Expression increases upon differentiation and is not related to the cell cycle
+Increased expression during development
+Expressed during development in yolk sacs and by embryonic endothelial cells. Expressed in the developing intestinal epithelium at the bottom of the intervillus pockets where undifferentiated cells are allocated (at protein level). In myogenic progenitor cells, highly expressed during early development (11.5 dpc) and progressively repressed as developments proceeds (PubMed:27446912)
+Expressed in the retina lens at 6 weeks post-conception (WPC) (at protein level) (PubMed:29777959). Expressed in the neural retinal between 6 and 19 WPC (at protein level) (PubMed:29777959). Expressed in developing photoreceptors and emerging interphotoreceptor matrix between 12 and 19 WPC (at protein level) (PubMed:29777959)
+During the cell cycle, levels increase and then remain constant until late mitosis after which they drop
+Widely expressed. Expressed at higher level in heart, liver and thymus from 18 dpc. By neonatal day 1.5, it decreases in brain, liver, gut and skin, while it is expressed in spleen
+Expressed in the cardiac cone, especially in the central region harbouring ventricular myocytes by 22 h post-fertilization (hpf). At 72 hpf, when the heart is an S-shaped loop, klhl24a transcripts are detected in the ventricle and at a lower level in the atrium
+Expressed at low levels throughout early development from unfertilized egg to late blastula when its expression level significantly increases
+Detected in the heart and vertebrae in embryos at 8 weeks of gestation (Carnegie stage 16), and in the long-bone cartilage at 9 weeks (Carnegie stages 19)
+Expressed in the embryonic retina, central nervous system and trunk (at the protein level)
+Loss of expression in the yellow and red fruits, after the breaker stage
+First detected on gestational day 15.5 in the epidermis
+Appears only at the late pupal stage; expressed at high level. Also expressed in the early adult (0-2 days old) at lower level. Expressed exclusively in the adult head
+Expressed both maternally and zygotically. Expressed throughout embryonic and larval stages
+Transiently repressed during the meiotic phase of spermatogenesis
+Predominantly expressed by stumpy forms, which are preadapted for differentiation into procyclic trypanosomes in the tse-tse midgut
+Expressed in prestalk cells in the slug stage. Expressed in both pstA and pstO cells up through early culmination and is subsequently repressed
+First expressed at 13.5 dpc, in the meninges, nasal mesenchyme, primordial cartilage and skeletal structures
+Expressed in early embryonic development (4-8 h) and in all later developmental stages
+First detected in the intermediate plate mesoderm, and subsequently in the nephrogenic cords of the urogenital ridges. Expressed in the developing limb. Also expressed in the myotome of the somites from 9.5 dpc, the oro-nasopharyngeal ectoderm and underlying mesenchyme, otic vesicles, the gut and its derivatives, and transiently in the liver at 11.5 dpc
+Expression begins after the mid-blastula transition (stage 8-8.5) becoming most abundant during neurulation, then gradually decreasing as development progresses. Expression remains in hatching larvae
+Expressed in all developmental stages (PubMed:17933869). Higher level of expression detected at the end of the third larval stage, in adult females and in early embryos containing maternally deposited transcripts (PubMed:17933869). At later stages of development, specific expression can be detected in tissues containing mitotic cells such as in the brain hemispheres and imaginal disks (PubMed:17933869)
+Expressed both maternally and zygotically throughout all development
+In intestine, the expression levels are highest during neonatal stages and decrease towards adulthood. In spleen, the expression is lowest in neonatals and increases during further developmental stages
+Highly Expressed during fruiting body formation
+Starts to express at the bicellular pollen stage, with a peak at the tricellular pollen stage
+Expressed in proliferating chondrocytes in the tibia at embryonic stage 15.5 dpc (at protein level). Expressed in limb buds at stage 11.5 dpc, where it colocalizes with Col2a1 and Sox9
+Up-regulated during T cell development, including upon the maturation of CD4/CD8 double-positive to CD4 single-positive thymocytes
+Expressed in embryos, with levels peaking around 6 to 9 hours after egg deposition, and then sharply decreases becoming undetectable at the first larval stage (at protein level) (PubMed:18250149). Reappears at the pupal stage when it is weakly expressed (at protein level) (PubMed:18250149). Strongly expressed in adult females but expression is low to absent in adult males (at protein level) (PubMed:18250149)
+Expressed in juvenile and adult mice from postnatal day 2
+Splicing is temporally regulated. Isoform 3 is expressed both maternally and zygotically, whereas isoform 2 is exclusively zygotic. Expression is highest in embryos from stage 12 on, with expression levels remaining constant throughout embryogenesis
+Expression begins in cerebellar Purkinje cells between postnatal day 8 (P8) and P10 and continues through adulthood
+Expressed in placenta during the first trimester of gestation (at protein level). In placenta, down-regulated at early hypoxic phase, and highly activated at 11-12 week of gestation
+Highly expressed in fetal erythroid tissue. Lower expression in yolk sac
+Expressed during parasite asexual blood stages, specifically at the late trophozoite and schizont stages (at protein level)
+Enriched in a subset of endothelial cells near presumptive tips of vessels and vascular buds (at protein level)
+Expressed maternally during early embryonic stages. Initially expressed throughout the embryo then expression is restricted to the brain region
+Expression gradually increases in the first weeks after birth (at protein level)
+Highest expression in endosperm at 7 days after pollination
+Expressed in the hypodermal regions hyp4 and hyp7 from the comma stage of embryogenesis and subsequently throughout development
+Stable expression throughout embryogenesis with more abundance after 5 days post-fertilization (dpf)
+Zygotically expressed first at a low level at stage 15. Expression is markedly increased up to stage 20 after which time the level of expression remains stable. Expressed in the presumptive pronephric anlagen at stage 26. Localized to pronephros, eye, branchial arches and tail-bud in the early tadpole stage (stage 32)
+Expressed in all life cycle stages, promastigote, metacyclic and amastigote forms but is found in the active form only in the promastigote stage
+Rapidly up-regulated in apical meristems during the transition to flowering. Transiently expressed in inflorescence meristem. Re-appears in stage 3 flowers, in the central dome that later will develop into stamens and carpels
+Expressed in embryos, maximal level between 5-12 hours (PubMed:1356269). Expressed in the hindgut mesoderm from embryonic stage 9 to the end of embryogenesis (PubMed:27618755). Also detected in the thoracic and abdominal segments from stages 12 to 14, persisting at high levels in thoracic segments T2 and T3 to embryonic stage 16 (PubMed:27618755)
+Transcripts remains very low during fruit development and dramatically increases during ripening
+In seeds, accumulates in endosperm and embryo. In torpedo-shaped embryos, restricted to the hypocotyl and in the outer parts of the young cotyledons. In later embryo stages, present in all tissues except root tips
+Expressed both maternally and zygotically, zygotic expression is at a low and constant level thereafter
+At 12.5 dpc, expressed in the neural tube and in the dorsal root and cranial ganglia. At 14.5 dpc, expressed in metanephric glomeruli, but not in the medullary region of the kidney, in the epithelium lining the gut, the stomach and the seminiferous tubules, as well as in lung. Expression is maintained in the dorsal root and cranial ganglia. In the cranial region, up-regulated in the epithelial and mesenchymal components of the tooth bud, in the epithelium lining the primitive nasal cavity, the vestibulocochlear and cochlear ducts and in the cranial ganglia. At 16.5 dpc, expression is maintained in kidney and lung. Detected in the papilla of the whisker follicle. In the eye, highly expressed in the cuboid epithelium of the lens and the inner nuclear (neuroblastic) layer of the retina. Expression begins in the brain, in particular the ventricular zone, and in the heart. At 18.5 dpc, expression is maintained in the brain, including the subventricular zone of striatum and olfactory lobe, the cortical plate, the cerebellar primordium and the inferior colliculus of the tectum. At this stage, the expression in the heart is 45 times lower than in the brain. At birth, still detectable in the metanephric glomeruli, but not in the adrenal gland
+Expressed at 5.5 dpc throughout the embryo except in the proximal visceral endoderm
+Detectable at postnatal day 20 when round spermatids begin to appear
+Is expressed in a uniform pattern in all embryonic cells prior to skeletal muscle cell formation in the myotomes of somites. Expression is first up-regulated in skeletal muscle at 12 dpc, this up-regulation is evident first in body wall muscle and one day later in limb muscles. At 13.5 dpc a most prominent expression is seen in all skeletal muscles. At this stage expression is seen in all other cells and tissues but at lower levels than in skeletal muscle
+Expressed in the ectoderm but not in the mesoderm or endoderm of the fetus at the second trimester (PubMed:12099555). At the second trimester, expressed in photoreceptor, bipolar, and ganglion cells of the retina, and in developing skin cells (PubMed:12099555). Expressed in developing neuronal cells of the brain and the spinal cord, but not in the peripheral nerves (PubMed:12099555)
+Expressed both maternally and zygotically. Expression is lost before gastrulation and begins again during somitogenesis
+In all 3 IRS layers, expression begins simultaneously in adjacent cells of the lowermost bulb above the germinative cell pool and terminated higher up in the follicle with the asynchronous terminal differentiation of each cell layer (at protein level)
+At embryonic stage 14.5 dpc, primarily expressed in the choroid plexus, and low expression in the heart and cartilage (at protein level) (PubMed:21349154). At 18.5 dpc, expressed in adrenal cortex, choroid plexus and bone (PubMed:17284679). Low expression in the brain of young, 2-month-old animals, except for the mitral cell layer of the olfactory bulb (PubMed:20404145). Strongly expressed in the brains of aged, 15- to 21-month-old mice with expression in the subgranular zone of the dentate gyrus and in the corpus callosum (at protein level) (PubMed:20404145). Also expressed in the CA1-3 regions of the hippocampus, as well as in the cerebellum, brainstem and cortex (PubMed:20404145). In vitro, up-regulated in senescent cells, including embryonic fibroblasts and oligodendrocyte precursor cells (PubMed:20404145)
+Most abundantly expressed at the blastoderm stage of embryogenesis
+Ubiquitously expressed in early embryogenesis (12.5 days). In later stages (14.5 days), the expression is restricted to cartilage forming cells, to specific neuronal cells and some epithelial derived tissues. In adults, SSXT is expressed in heart, kidney, testis and also in muscle, brain and liver. In mature testis, expression is specifically observed in primary spermatocytes
+WUN1 expression may be correlated with cell death as old and dying tissues contain high levels of WUN1 mRNA in the absence of any wounding
+First observed in vascular tissues, lateral root primordia, and root meristems
+Not regulated during leaf senescence
+In far-red light (FR)-treated seeds, present in the whole embryo (PubMed:22483719). Accumulates upon red light (R) (PubMed:22483719)
+First detected in presumptive postmitotic neurons in the developing neural tube at embryonic day 9. Expressed in 14 dpc retinas, and expression continued after birth with a slight decrease between P12 and P15. In the 14 dpc retina is mainly and strongly expressed in the NFL. In P1 and P5 retinas strong expression is confined to the IPL and also in NFL. At P10 and in the adult retina strong expression is detected in the IPL, and weak expression in NFL, OPL, and inner nuclear layer. Is expressed on postmitotic mature neurons
+Maximally expressed late in pollen development
+Strongly up-regulated in the intestine in late gestation
+First expressed in early to mid-globular-stage embryos. In late globular stage, detected as a stripe running medially across the top of the embryo. In heart stage embryo, expression is restricted to a notch between the cotyledons, in both hypodermal and protoderm cells. In the bending-cotyledon stage, localized in the SAM, but disappears from the boundary region of cotyledon margins (BCM). In seedlings and adult plants found in all shoot apical meristems. In the inflorescence meristem, expression disappears as floral buds are initiated and reappears in the later floral meristem where it is found in the central portion of the developing gyneocium. Also detected in the L1 layer of embryo
+In testis, weakly present from 8 dpp, and readily detectable from 10 dpp, with expression sustained through adulthood. Present in all populations of spermatocytes (at protein level)
+Not expressed in vegetative cells, but is transiently induced during the aggregation stage of development
+Expressed both maternally and zygotically. Widely expressed at the early gastrula stage. Expressed throughout early embryogenesis until at least the tadpole stage
+Expressed in proliferating larval blast cells including seam cells in the lateral hypodermis, P cells in the ventral hypodermis, and intestinal cells. Within the P cell lineage expression levels correlate with the proliferative state, being low in newly hatched larvae and then increasing in L1 as P cells begin to proliferate. Not expressed in the adult cells of the P lineage which are postmitotic. Also expressed in some non-proliferating cells such as the lateral hyp7 hypodermal cells, rectal gland and epithelial cells, and a subset of neuronal cells in the head and tail regions
+Sporozoite antigen
+The production of subtilosin A begins at the end of vegetative growth and finishes before spore formation
+Expressed during the asexual blood stage; expression is low at the ring stage and peaks in trophozoites and schizonts (at protein level)
+Senescent tissues specific expression (Ref.6, PubMed:10579486). Detected only after significant visible yellowing (PubMed:9617813). In unfertilised pistils, accumulates transiently shortly after anthesis, and increased again at the end of pistil development (PubMed:21575215). In ovules, first observed at the basal zone of the ovary, and progressively extend acropetally along the ovary (PubMed:21575215)
+Expressed in the connective tissues of differentiating tendons and synovial joints (PubMed:19235716). Expressed in the uterus during window of implantation and early pregnancy (at protein level) (PubMed:29901777)
+Expressed both maternally and zygotically with low levels of expression throughout the life cycle
+Expressed both maternally and zygotically throughout embryonic development and in adult hermaphrodites
+Expressed in the vegetative cells and decreases during subsequent developmental stages (6-24 hours)
+Expression starts around 9.0 dpc in the neural folds, which give rise to neural crest cells. Neural crest cells develop into various tissues, including the sensory ganglia that contain nociceptor cell bodies. Prominently expressed in sensory spinal ganglia (dorsal root ganglia) but not in sympathetic ganglia during the time when sensory neurons emerge (10.5 dpc-13.5 dpc), mature and differentiate (14.5 dpc-postnatal day 14)
+Accumulates in an adaxial ball-shaped set of cells in three to five cell layers around the L3 layer of the shoot apical meristem (SAM) in youg plantlets. In the inflorescence meristem, confined to the axils of flower primordia
+Expression in testis starts at P20
+Expressed in the heart and in the tail bud at 8.0 dpc, and then in the cranial and dorsal root ganglia. Also expressed weakly and transiently in the intestine, lung and in bone marrow
+Expressed in late larvae of both sexes. In the fourth larval stage, expression is approximately six-fold higher in males than in hermaphrodites. Expressed in ADF chemosensory neurons in males from the L4 larval stage (PubMed:31264582). Expressed in cells of the male tail tip from the L4 larval stage (PubMed:18550714). Not expressed in cells of the hermaphrodite tail tip at any developmental stage (PubMed:18550714)
+Expressed by 15.5 dpc in both skeletal muscle and heart. Expression is maintained throughout adulthood
+Expressed at low levels in prespore cells at the tipped aggregate stage, expressed in the anterior funnel cells in slugs, and then become enriched in upper cup cells during culmination
+Expressed at only a very low level in exponential-phase cells and germinating spores, but is expressed at a higher levels upon entry into the stationary phase of growth
+Activity is maximal during the early stationary phase
+At postnatal P0, expressed in heart, lung, liver, kidney, spleen and inner ear (PubMed:27162350). In the inner ear, at 14.5 dpc, detected in spiral ganglia, the cochlear epithelium and the vesitbule. At 17.5 dpc, expression increases in spiral ganglion neurons axon terminals adjacent to auditory hair cells. In the differentiating cochlear epithelium, the expression is intense in the stria vascularis. By P0, expression in the stria vascularis is weakened (PubMed:27162350)
+Predominant isoform in 17 dpc brain
+Predominant isoform during postnatal development. Detected in the ventral horns of the spinal cord at 12.5 dpc, and throughout the spinal cord at birth
+Expressed in mature oocytes followed by a severe reduction in protein levels as meiotic division progresses (PubMed:23578927)
+Expressed in embryos in the central nervous system but not in the peripheral nervous system (at protein level)
+Expression of the gene dramatically increases in the pre-eclosion period
+Expressed maternally. Restricted to the dorsal blastoderm margin in early gastrula and the future dorsal side of the embryo at the sphere stage. At the shield stage, expressed throughout the shield and in lateral areas. Expressed in the anterior brain and axial mesoderm at the tailbud stage, and subsequently maintained in the lateral mesoderm. During somitogenesis, up-regulated in the anterior of the older somites, and expressed in the posterior presomitic mesoderm and tailbud
+Expressed both maternally and zygotically. Expressed in embryos and adults (females only)
+Detected in ventral mesencephalon from 10.5 to 15.5 dpc; expression levels decrease moderately, but steadily during this period (PubMed:20018874). Detected in the lateral plate mesoderm surrounding the ventral aspect of the anterior foregut from 9.0 to 10.5 dpc (PubMed:19686689). Detected in the developing mesenchyme with higher levels surrounding the distal regions of the branching airways from 12.5 to 18.5 dpc (PubMed:19686689)
+During development, expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons and the roof of the dorsal aorta. Prominently associated with heart formation and continuously expressed in the myocardial lineage from the initiation of myocardial differentiation through to formation of the differentiated, two chambered heart. First detected in anterior lateral plate mesoderm (ALPM) and by the 5- to 10-somite stages, strongly expressed in ALPM and in two bilateral groups of mesenchymal cells close to the anterior notochord and in a crescent of lateral plate adjacent to the tail. At the 6- to 8- and 12- to 14-somite stages, expressed throughout the ALPM. Between the 10 and 15-somite stages, expressed throughout the myocardium. At the 18-somite stage, expressed in the loosely packed mesenchymal cells in the midline immediately anterior to the heart fields. Later expression seen in the cardiac cone, cardiac tube and ventricle
+Expression in embryos is first seen 12 hours after oviposition, peaks at 24 hours and decreases to a low level by 48 hours. Low levels are seen during larval and early pupal development. Levels increase during late pupae to maximal at the adult stage
+First detected shortly after the midbastula transition. Levels increase during gastrulation, persist through early somatogenesis, but then decrease and are gone by 24 hours
+Expressed at the base of the inflorescence meristem and at late stages of development in petals and stamens. Up-regulated during leaf senescence
+In the testis, expressed mainly in A dark spermatogonia, mid and late spermatocytes and spermatids but not in mitotically active A pale and B spermatogonia
+Not detected in testis from neonates. Expression in testis is first detected 14 days after birth and increases thereafter. Highly expressed 30 and 84 days after birth
+Expressed throughout development (PubMed:30336114). First expressed in embryos at the 1-cell stage, but, in contrast to hmg-4, expression begins to decrease in somatic cells from the 8E stage until the 2-fold stage (PubMed:30336114). However, expression in the germline persists throughout the larval and adult stages (PubMed:30336114)
+Expressed at moderate levels throughout the life cycle
+Expressed in all stages of development
+During the cell cycle, highly expressed in S, G2 and M phases
+Accumulates and reach a peak shortly before full senescence, at the interface between the green and yellow regions of senescent leaves, and then declines (PubMed:9617813, PubMed:21736589). In flowers, restricted to the pollen and very weak expression in petal veins. In dark-treated seedlings, strongly expressed throughout the root tissues, including root hairs, except in primary and lateral root tips (PubMed:21736589)
+As early as embryonic day 18, there is a higher level of expression in the whole brain compared to adults. Expression continues to rise at birth (P0) and remains elevated over adult levels until P10-P14, when it begins to decline (PubMed:28662698). Highly expressed throughout the P1 brain, including the cortex, hippocampus, cerebellum, midbrain, and hindbrain, there is very little expression in the adult brain except in the hippocampus (PubMed:28662698)
+Detected in brain cortex at 15.5 dpc and in neonates, but levels decrease 16.5 days after birth and are very low in adult brain cortex (at protein level)
+Predominantly expressed in hepatocytes during liver development
+Expressed during zoosporogenesis
+Expressed in larval stage L4
+Isoform 3 is weakly expressed at 17 dpc but its expression increases after birth
+Expressed in the ocular tissues of the retina at 10.5 dpc and becomes restricted predominantly to the photoreceptor layer in the mature retina (at protein level). Expressed in the embryo at 7 dpc
+Rapid decrease in leaves from the leaf opened to the green fruit stage (PubMed:30577538). At the leaf opened stage, accumulates mostly in leaves (PubMed:30577538)
+In roots, mostly expressed in the cells of the lateral root cap and epidermal cells at the root tip (PubMed:16877699, PubMed:20498067). In shoots, confined to the stipules (PubMed:16877699)
+Asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube
+Present at all developmental stages (at protein level)
+The level of mRNA increases 4 hours after starting starvation and remains relatively constant thereafter
+In brain of prenatal day 18 embryos, the expression is detected throughout the mantle zone of fore-, mid-, and hind brain. In the cerebrum, the expression is intense in the cortical plate and weak in the ventricular zone. At P49, expressed in the gray matter of the entire brain by hippocampal pyramidal cells, dentate granule cells, and cerebellar granule cells and to a lower extent by olfactory mitral and granule cells and the cerebral cortex. Weakly expressed in the diencephalon and brain stem and not detected in the cerebellar medulla. Expression is much higher in the fetal brain than the adult brain, especially in the brain stem
+Expressed both maternally and zygotically. Highest levels in embryos and lower levels in larvae and adults
+Highly expressed in embryonic stomach, midgut and colon during the period of visceral smooth muscle cell differentiation; levels decrease rapidly thereafter (PubMed:22683258). mRNA already detected at stage 7-8 in the cardiogenic mesoderm, and become almost undetectable in the outer curvature of the ventricular region whereas remaining high in the developing atrial regions (PubMed:10096065)
+First expressed mid-gastrulation, at the 200-cell stage of embryogenesis with expression increasing during epidermal morphogenesis. Also expressed in epidermal cells and also in the underlying neuroblasts during embryonic development
+During development of the prepuberal testis high levels of HOXA4 transcripts were found at days 17, 24 and 30. The first day of HOXA4 expression was day 14. The activation of the HOXA4 gene in male germ cells seems to occur at the pachytene stage of meiotic prophase and its level of expression is stage-specific during embryogenesis
+Expressed in developing seeds from 1 to 20 days after flowering (DAF)
+Ubiquitously expressed in the embryo (at protein level). Ubiquitously expressed in the developing eye (at protein level)
+Expressed in the cerebral cortex on 17 dpc and in olfactory bulb and hippocampus on postnatal day 1 (P1) (PubMed:26623514). Expression in hippocampus increases during postnatal development and reaches a plateau after 3 weeks (PubMed:29199957). Expression is high during prenatal development and decreases in the thalamus and brainstem during postnatal development (PubMed:26623514)
+Increases dramatically after starvation is initiated with a peak between 4-12 hours
+Expressed in embryonic life, with a dramatic peak at day 11 of gestation. At 10 dpc, it is prominently expressed in cells scattered throughout all neuroepithelia, it is also detectable in cranial and dorsal root sensory ganglia, and spinal cord. At 14 dpc, outside the nervous system, it is detectable in vibrissae, dermis, and to a lesser extent in skeletal muscle, lung, and kidney
+Expressed at a low and constant level during growth, sporulation, and spore germination
+Not expressed maternally. First detected at 8 hours post-fertilization (hpf) during gastrulation, with expression being restricted to the posterior epiblast. Expression then increases, reaching a peak at 24 hpf and decreasing from 30-48 hpf. At 9 hpf, expressed throughout the dorsal epiblast except at the dorsal midline, and ventrally in prospective tail and head regions. At 10-11 hpf, expressed in presumptive hindbrain, posterior neural plate, lateral mesoderm and tail bud. At 12 hpf, strongly expressed in the neural epithelium and tail bud and expressed at low levels elsewhere including the eye. At 24 hpf, restricted to the hindbrain with an anterior border at rhombomere 6-7, to anterior spinal cord and to head mesenchyme just posterior to the otic vesicle. At 48 hpf, hindbrain expression remains and there is diffuse expression in non-neural tissue in the pharyngeal region
+Present in all embryonic blastomeres at early stages of development (at protein level)
+Expressed in limb buds at 9.5-11.5 dpc
+Protein amounts in liver decrease significantly with age
+Expressed throughout the embryo during all steps of embryogenesis, and decrease toward the bent-cotyledon stage
+First expressed in blastomeres in early gastrulating embryos (PubMed:21307099, PubMed:26153233). Expression continues throughout embryonic development with expression in neuronal and non-neuronal progenitors (PubMed:21307099, PubMed:26153233). During larval development, it is expressed in cells including vulval, hypodermal and intestinal cells, and is only expressed in RMH motor neurons (PubMed:21307099, PubMed:26153233). First expressed in the progenitor sex myoblasts at the 16-M cell stage of mesoderm development in hermaphrodite larvae and thereafter in descendants (PubMed:21307099)
+Induced during conidial germination
+Induced in the cells forming the adventitious root primordium in connection to the primary xylem. Accumulates in the protruding adventitious roots
+Expressed at low levels in all stages of embryonic development examined
+Expressed in embryo at 3 days after pollination (DAP)
+Expressed in 24 hours embryo
+Expressed in a caudal domain whose anterior boundary expands from the r3/r4 boundary during late gastrulation to r2 during somitogenesis stages. Also expressed at the midbrain to hindbrain boundary by the 3-somite stage, where expression intensifies by the 6 somite stage. Also expressed in the spinal cord and tailbud
+Expressed only during embryonic stages
+Expressed in mature flowers with a peak 6 to 7 days postanthesis
+Expression starts at the gastrula stage, increases at the prism stage and peaks at the puteus larva stage. Expression is restricted to the oral epithelium
+Probably expressed both maternally and zygotically
+Expressed during the asexual blood stage, including in trophozoites (at protein level)
+Detected between 15 dpc and 20 dpc, between P0 and P10, and in adult in different regions of the telencephalon and diencephalon
+In flowers, mostly expressed in stigma and pollen, and moderately present in sepals and stamen filaments. In siliques, observed at both ends, gradually disappearing toward the center
+High levels are detected during the first half of embryogenesis reaching a maximum between 4 and 8 hours of development. Protein expression increases again from the third larval instar onwards. It is expressed in a maternal/early embryonic phase, and again during morphogenesis in late larval and pupal stages
+Expressed in embryonic stem cells (ES)
+Detected in larvae (at protein level) (PubMed:28814510). First detected in the dorsal region of the embryo at 15 hpf. Detected along the ventral edge of the neural tube from 22 to 32 hpf. Highly expressed in retina, cranial ganglia, pectoral fin, brain and spinal cord at 48 hpf (PubMed:21520329). Detected in primary motor neurons along the ventral edge of the neuron tube at 24 hpf (PubMed:27484901)
+Expressed, as early as 12 hours post fertilization, in cells migrating from the epiblast and forming the hypoblast layer. Later on at 72 h, preferentially expressed in cells of the developing vascular and nervous systems
+First expressed in embryos at 8.5-9 days in facial and branchial arch mesenchyme, otic vesicles and frontonasal ectoderm around olfactory placodes, a day later expression is seen in the developing forebrain in primordia of the ganglionic eminence and ventral diencephalic regions. In day 12.5 embryos, expressed in the brain and bones, and also in all skeletal structures of midgestation embryos after the first cartilage formation, and expression progressively declines in both brain and skeleton in day 15 embryos
+Appears in sperm during epididymal transit
+Expression is down-regulated during bradyzoite development
+Expression increases during brain development from P2 to adult (at protein level)
+In the developing nervous system, first detected in the neural tube at 9.5 dpc. By 10.5 dpc, levels increase throughout the brain, with highest levels in the hindbrain and in the spinal cord, expressed only in the rostral half. By 11.5 dpc, expression found throughout the brain and spinal cord. From 12.5 dpc, expression restricted to the ventricular regions of the brain, peaks at 13.5 dpc and declines thereafter. Only weak expression in the developing spinal cord from 11.5-16.5 dpc. In the developing retina, expression is confined to the undifferentiated retinoblastic cell layer. In other developing tissues, E2F1 is expressed in kidney, lung, liver hepatocytes, heart and thymus. Highest levels in liver. Absent in choroid plexus
+Expressed in L3 larvae (at protein level) (PubMed:8435436, PubMed:12742584, PubMed:17933581). Expressed at low levels in host lung L3 larvae (at protein level) (PubMed:17933581). Not expressed in adults (at protein level) (PubMed:12742584, PubMed:17933581)
+During embryogenesis, maternal transcripts levels are very low through cleavage and blastula stages. Zygotic transcripts are first detected in the early gastrula at stage 10. Transcripts levels increase through tailbud and tadpole stages. At stages 31/32, expression is seen at the surface of the embryo in a line ventral to the posterior edge of the optic cup. At stages 33/34, two short lines of cells exist running ventrally from the anterior edge of the otic vesicle. At stages 35/36, expression is seen in cells near the cement gland and in a patch of cells located posterior to the gill arches, and just beneath or within the inner layer of the epidermis. At stages 37/38, expression forms a ribbon on either side of the embryo. At stages 40, a second line runs caudally along the flank of the embryo. By stage 42, extension occurs and a line is observed ventro-caudally around the anus
+Present in low amounts in growing cells and increases steadily during development. Specifically localized in maturing spore
+Expressed at low level in germinating seeds 3 to 5 days after imbibition
+Expressed in the retina from early somitogenesis (stage 19) onwards
+Alpha-6 levels decrease with age
+Schistosomula, lung stage worms, and adult worms
+Expression detected in the embryo at 7.0 dpc, 11.0 dpc and 15.0 dpc and also in the adult
+In postpubertal testis, isoform 6 is expressed from stages IV-V of spermatogenesis in the outer layer of round spermatids. Expression continues through stages VI-VII but no expression is detected in stages IX-XI. In prepubertal testis, isoform 6 is expressed in post-meiotic germ cells at the round spermatid stage
+Expressed predominantly during early aggregation and at low levels during later stage
+Expressed in the developing ceratobranchials and abdomen from 3 to 6 dpf
+Expressed on day 14 dpc in prepubertal testis, expression reached its plateau on day 21 dpc and remained at a high level in adult
+Expressed during late heart stage embryo in the SAM region between the two developing cotyledons. Expression is initially down-regulated in incipient floral primordia but a strong expression is subsequently detected in the central region of young floral primordia and the inner whorl of developing flowers. In fruit, is expressed in the replum of developing ovaries
+Expressed on differentiating neuronal cells from the onset of neurogenesis in both the central and peripheral nervous systems
+Expressed both maternally and zygotically. Expressed at a low level in fertilized eggs and cleaving embryos. Zygotic expression begins after the midblastula transition (MBT) with expression levels rising during gastrulation, and remaining constant throughout neurulation and premetamorphic development. Also expressed in adults
+Expressed in fetal brain but not adult brain
+Does not appear to be maternally expressed. Zygotic expression begins at late blastula, increases at mid and late gastrula, and peaks in the early neurula. Expression is restricted to the anterior nervous system
+Expressed in growing cells at low levels. Expression increases following initiation of development. Peaks around 12 hours (tipped aggregate stage), and remains at a high level throughout the remainder of development
+Faintly expressed in embryos at 9-12 hours. Expression increases rapidly as the nervous system matures, peaking just prior to hatching. A second peak is observed in late pupal stages around 73-108 hours postpuparium
+Highly expressed in seeds and glumes at 15 days after anthesis (daa). Highest expression in pericarp tissue of seeds at 20 daa. Moderately expressed in flag leaf at the soft dough seed stage. Weakly expressed in young seedling leaves 1, 3 and 5. Hardly detectable in inflorescence at 0 daa. Not expressed at the soft dough stage in old leaves near the bottom of the plant. Expression shows a progressive increase from the bottom to the top of the plant coinciding with the accumulation of leaf pigments
+Appears on egg day 7.5, becomes more active on day 8-8.5 and disappears on day 9.5
+Same abundance in amastigote, epimastigote, and trypomastigote
+Adults
+Up-regulated in actively dividing cells, including in peripheral blood mononuclear cells stimulated with Concanavalin-A. Down-regulated in differentiating cells, including in neural precursor cells induced to differentiate into astrocytes
+In roots, observed in the central cylinder (vascular tissues), but absent from division zones (PubMed:24112720, PubMed:24513716, PubMed:24778257). Present in the vascular system of the cotyledons and rosette leaves (PubMed:24112720, PubMed:24513716). Also observed in phloem cells of the flower stem (PubMed:24112720). Accumulates also in the mature anthers of open flowers and in siliques (PubMed:24513716)
+Transient induction at 8 days post-anthesis. ODC activity seems to be related to active cell division
+The RNA is supplied maternally, and later on, expression is ubiquitous during all stages of embryonic development
+Expressed in fetal ovary
+In the embryo, levels are low at 10 hours post-fertilization, then increase over the 14-24 hpf period, and stabilize after 36 hpf (PubMed:29757409). Mainly expressed in the central nervous system at 24 and 36 hpf, and is concentrated in the brain by 45 hpf (PubMed:29757409). Widely distributed around central arteries in the developing hindbrain at 42-45 hpf (PubMed:29757409)
+Expressed in mammary tissue throughout development (at protein level). Strongly up-regulated during pregnancy, falls during lactation and is again up-regulated during involution of the gland at weaning
+Expressed both maternally and zygotically. Expressed throughout the embryo but is activated specifically at the poles (PubMed:2927509, PubMed:8423783, PubMed:19965758). Expressed in the prothoracic gland in wandering L3 larvae (PubMed:19965758)
+Expression in the brain begins at 12.5 dpc, peaks at 16.5 dpc, and decreases postnatally
+At embryonic day 16 (16 dpc) can be detected in the hippocampal anlage, thalamus, cortex and olfactory bulb. At perinatal stages (20 dpc to P1) shows a strong expression in the cortex and hippocampus and subsequently declines at later postnatal stages
+Highly expressed during seed maturation
+Present in both immature and mature oocytes (at protein level). Expressed at a constant level during oocyte growth as well as during oocyte maturation. Levels decline somewhat during cleavage (stages 3-6). Levels rise dramatically during the mid-blastula transition. This higher level of expression is then maintained through gastrulation and all subsequent developmental stages
+Expressed throughout the B-cell lineage prior to the plasma cell stage but occurs at highest levels in mature B-cells. Highly expressed in cells representing mature stages of B-cells but weakly expressed in pre-B cells, immature B-cells, and memory B-cell stages. Not detected in plasma cells
+Expressed from midgestation to adult life
+Expressed in the conidium only during the process of appressorium formation induced by avocado surface wax
+Expressed in developing seeds from 10 to 12 days after flowering (DAF)
+Expressed during parasite asexual blood stages, including in schizonts (at protein level)
+Expressed at 14.5 dpc in cerebral cortex; expression increases over time in cultured neural stem/progenitor cells
+Embryonic axonogenesis
+Before gastrulation, expression is barely detectable. At 7 hours post-fertilization (hpf), sharply up-regulated. High-level expression continues throughout the segmentation (12 hpf) and pharyngula (24 to 30 hpf) stages. At hatching at 51 hpf, expression declines dramatically
+Expressed predominantly in the developing gonad, nervous system somites, surface ectoderm and limb buds
+Expressed in the gastrula stage of embryos but becomes absent by late neurula stage
+Present in substantial amounts in oocytes, declines in abundance in early embryos, and begins to increase during mid-embryogenesis. Levels peak in the third instar larva then decline during pupal stages, rising again near the time of eclosion
+Expression starts at the early embryonic pretzel-stage in the intestine and in a few cells in the head and the tail, and continues throughout larval stages and adulthood
+Expressed throughout development from embryos to adults
+Expressed in body wall muscles, pharyngeal muscles and most neurons at all stages from late embryogenesis until adulthood. Expressed in hypodermal seam cells until the L4 stage
+Expressed at all developmental stages, with highest expression at the posterior pole of the early cellular blastoderm, the neuro-ectoderm prior to neuroblast delamination, rows of epidermal cells in the most posterior part of thoracic and first abdominal segments and a ring of epidermal cells at the posterior end of the embryo
+Expression detected initially in the gastrula-stage embryos and continuing throughout all developmental stages to adulthood
+Clock-regulated. The peak of GAPDH activity lags several hours behind the peak in mRNA accumulation in the late night
+Expressed from embryo day 9.5 to birth. In day 13.5 embryo, expressed abundantly in cells coating the neural tube. Expression continues posteriorly in the spinal cord, the dorsal root ganglia, in the prevertebal sympathic ganglia and the ganglion nodosum. High expression found in the dorsal and anteriolateral primordium of the midbrain. Expression also found in skin, kidneys and in many areas of the facial mesenchyme. In adults, expressed in the eye, skin, kidney, prostate, thymus, skeletal muscle and, very weakly in the brain. Highest levels found in kidney
+In embryos, expressed in the ventral neurons, motor neurons and in the longitudinal interneuron axons (at protein level) (PubMed:23892553). May also be expressed in the motor neuron dendrites or possibly the glia (at protein level) (PubMed:23892553). Expressed 48 hours after puparium formation in the lateral glomeruli of the anterior and central regions of the antennal lobe, including the DA1, VA1d and VA1v glomeruli (at protein level) (PubMed:25741726). Expressed zygotically (PubMed:12617819). High levels of expression in embryos and pupae, and relatively low levels of expression in larvae and adults (PubMed:10973475). At germ band extension, expressed as 14 stripes in the embryo (PubMed:12617819). At germ band retraction, expressed in a subset of neurons in the CNS, the precursors of the leg imaginal disks and in the ventral epithelium of the large intestine (PubMed:12617819). Expressed in the posterior and anterior spiracles (PubMed:12617819). In stage 16 embryos, expression decreases and is mainly localized to the CNS (PubMed:12617819). Expressed in the proximal region of the wing imaginal disks, around the wing pouch and hinge regions (PubMed:21158756). Also expressed in the distal segments of the leg imaginal disks, with high levels of expression around the A-P border of the tarsal to tibia segments (PubMed:21158756). In larvae, detected in the fat body (PubMed:12617819)
+Expression starts at postnatal day 20 and continues throughout adulthood
+In the embryo, first expressed at the doming stage (4.2 hours). Highest expression is found between 5.2 and 9.5 hours (epiboly) after which levels gradually decrease, with expression becoming absent by 48 hours
+First appears in follicular cells at late vitellogenic stages that is approximately 12 hours prior to the onset of choriogenesis, its accumulation declines at the onset of choriogenesis and is present at lower levels throughout choriogenesis
+In seedlings, confined at the base of rosette leaves and in root vascular tissues (PubMed:25009544). Accumulates in pericycle cells precursors of lateral root meristems and remains at the base of growing lateral roots, but not in tips (PubMed:25009544). In the inflorescence, strongly expressed in young anthers and present in carpels (PubMed:25009544). Fades out in mature flowers (PubMed:25009544)
+In seedlings, mainly localized in meristematic tissues (e.g. shoot apical meristem SAM, root tips, and growing leaf and lateral root primordia). Present in all the vasculature and the shoot apical meristem (SAM) of the adult plant. In flowers, localized in carpels and developing ovules. In the root tips, expressed in and near the vascular initial cells
+First expressed in 19-day old nodules
+In the developing epidermis, first detected in 13.5-14.5 dpc embryos. With the appearance of stratified epithelium, levels of E2F5 expression increase and by 16.5 dpc, high expression found in the suprabasal cell layers. High expression also found in other regions with stratified squamous epithelia including the developing palate, lip and tongue. In the developing nervous system, first detected in the forebrain at 9.5 dpc. At 10.5 dpc, strongly expressed in the rostral region of the spinal cord. By 11.5 dpc, E2F5 is expressed throughout the developing central nervous system. In 12.5-15.5 dpc embryos, expression found in the undifferentiated ventricular regions of the brain. In the retina, expressed, in 14.5-18.5 dpc embryos, in the retinoblastic cell layer. In other developing tissues, highly expressed in the choroid plexus. Also found in the kidney, liver, lung, heart and weakly, in developing skeletal muscle and chondrocytes
+Expressed at all stages of mammary gland development, but at lower rate at early and mid pregnancy. Expressed in 1-cell and 2-cell stage embryos
+Colocalized with actin in the oral apparatus in interphase cells. In dividing cells colocalized with actin in the division furrow
+Expressed at low levels at 7-9 gestational weeks and then increases at later stages, including in the non-cortical plate region at gestational week 21, containing the outer-subventricular zone (PubMed:29856955). Expressed at lower level than NOTCH2NLB (PubMed:29856955)
+First expressed at 14.5 dpc in the suprabasal layers of developing epidermis, at 15.5 dpc expression begins in the inner cells of developing hair germs and restricted to inner root sheath and/or precortical cells of developing hair follicles
+Expressed in VPCs and hypodermal cells during larval development (PubMed:18700817). Expressed in VPCs of L3 stage larvae prior to and during cell fate specification and in the seam cells of L1 stage larvae and adult animals (at protein level) (PubMed:18700817). Expressed in developing uterus of L4 stage larvae and in the spermatheca (at protein level) (PubMed:18700817)
+Expressed maternally and throughout embryogenesis
+In the brain, expression starts at 12 dpc and increases until adulthood
+Expressed during embryogenesis in the root meristem at the transition from heart to torpedo stage. At the cotyledon stage, expressed in root and shoot meristems, with weak expression in provascular tissues. Expressed later in the seedling root meristem, shoot apex, and vasculature. During flowering, expressed in inflorescence and floral meristems, and in petal, stamen, and carpel primordia
+Expressed during growth and development, with the highest level of expression during aggregation
+Highly expressed in epidermis, dermis and the outermost periderm layer in the 17 day post-coitum (dpc)
+In the testis, expressed at all stages of development
+Detected as early as embryonic day 13, shortly after the onset of sexual dimorphism of the gonads. Dramatically increases at the end of the embryonic development and peaks at 2 dpp, a time in ovarian development at which oocytes have become enclosed in primordial follicles. Decreases markedly by 7 and 14 days after birth. Persists, but at low level, in adult females. Not detected in male embryos, but detected in adult testes
+Expressed at all developmental stages from the one-cell embryo
+Expression is stronger in winter than in summer
+In knee epiphyseal cartilage, expression is detected from 12.5 dpc onwards, with significant up-regulation at 16.5 dpc and again at postnatal day 5. Expressed at least until 10 months of age
+Expression already detected at 9.5 dpc and maintained throughout embryonic development. At 17.5 dpc, high levels found in tendons and ligaments of the skeletomuscular system, including the knee joint, the upper limb and the intercostal ligaments. At this developmental stage, high expression is also detected in the tendinous part of the diaphragm. By contrast, low levels are observed in resting and proliferative chondrocytes of long bones and vertebral bodies, and in the cartilaginous part of the intervertebral disks. No expression in hypertrophic chondrocytes. Outside the skeletomuscular system, expressed in neuronal cells of all brain regions and the spinal cord, liver, lung, bowels, thymus and eye
+Expression is reduced during terminal differentiation. Expression is induced in the G2/M phase of the cell cycle (at protein level)
+Expressed at high levels in zygotes and at lower levels in germinal vesicle (GV) stage oocytes and MII-stage oocytes. Expression strongly decreases from 2-cell stage to blastula
+Expressed in fetal lung
+Expressed during conidiation. No expression in vegetative or sporulating aerial hyphae
+Expression is strongest in anterior and ventral regions of the ovary at 12.5 and 13.5 dpc before becoming more uniform
+Expression is intermittent being high during larval molting and both the larval-pupal and the pupal-adult transformations
+Expression in oligodendrocytes is highest between the second and third postnatal week and low in the adult. In contrast the expression in neurons increases from birth to third postnatal week and is continuous from late development to adulthood. Isoform 1 is the dominant form early in development. Isoform 2 is more prominent later in development and in adulthood
+Highly but transiently expressed in enterocytes and hemopoietic cells populating the liver during development, but is absent when animals are fully developed. Highly expressed in the eyes of the developing embryos as early as 12.5 dpc and developing CNS
+Peaks of expression at the time of rosette development and flowers production
+Expressed from two-cell to blastocyst stage of embryo development
+Expressed both maternally and zygotically. Found in ovaries and abundant in early embryos. Also found in variable amounts at every stage of the life cycle
+Expression preceeds the onset of myogenic differentiation, and continues in cardiomyocytes of embryonic, fetal and adult hearts. It is also expressed laterally in future pharyngeal endoderm which is believed to produce the heart inducer. After foregut closure expression in endoderm is limited to the pharyngeal floor, dorsal to the developing heart tube. The thyroid primordium a derivative of the pharyngeal floor continues to express the protein after its levels diminish in the rest of the pharynx
+Ubiquitously expressed in embryos. Detected from stage 7 dpc onwards, reaching peak levels at stage 11 dpc and declining by stages 15 dpc and 17 dpc
+Undetectable until 20 days post partum (dpp), and becomes detectable only after 22-30 dpp (PubMed:22110678). Expressed after postnatal day 15 and expression gradually increases with age (PubMed:29700843)
+Metamorphosis; thyroid hormone-induced tail resorption
+Maximal expression is found during the third larval instar, it drops to become undetectable in the late pupal stage. The expression in adults is similar to that of first and second larval instars
+Specifically expressed by monociliated cells of the ventral node from the late streak to early somite stage
+Expressed in eggs (PubMed:11589574, PubMed:15777697). Not expressed in hatched second-stage juveniles or in young females (PubMed:15777697)
+First expressed during embryonic development at 1 somite at 10 hours post-fertilization (hpf) (PubMed:29791979). During embryonic development, expressed in the epidermis, mouth and pharyngeal arches at 48 and 72 hpf (PubMed:12464617)
+Highly expressed in conidia
+Starts to be expressed in seeds from 18 days after pollination (DAP) to reach the highest expression in dry seeds. Expression is strongly reduced after only 2 hours of seed imbibition, declines drastically after 6 hours, but can be detected at a very low level even after 10 hours
+Expressed throughout the central nervous system from segregation of neuronal precursors through the end of development. Also detected in cephalic sensory structures
+Abundantly expressed during embryogenesis and to a lesser extent in larvae and adults (PubMed:1286611). Expression starts at the 100-cell stage and persists through embryogenesis (at protein level) (PubMed:9027313). Not expressed in larvae and adults (at protein level) (PubMed:9027313)
+Expressed in embryo at 7 dpc onwards
+Expression increases moderately during embryonic development and remains stable in the postnatal brain (PubMed:21228389). Highly expressed in uterus luminal epithelium after embryo implantation (PubMed:26107991)
+Specifically expressed in radial glia cells of cortical neural stem and progenitor cells (NPCs) during neocortex development. Preferentially expressed in apical and basal radial glia (PubMed:25721503). Not detected in cortical neurons and cortical plate (PubMed:25721503)
+The isoforms are differentially expressed during development. Isoform 1 is expressed maternally with expression gradually decreasing as development progresses, whereas expression of isoform 2 is barely detectable during the first 12 hours post-fertilization (hpf) but increases by the second day of development
+Accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis
+Expressed at the end of vegetative growth
+Expressed before the L1 to L2 stage molt
+Widely expressed in the developing cortex at 14.5 dpc
+Detectable in stage I oocytes, increases through stages III and IV, then slightly declines as the oocytes mature to stage VI. Present in early embryogenesis until midblastula transition, at which point it becomes undetectable
+Expressed throughout development, but higher expression in both embryo and adult stages (at protein level) (PubMed:16567400). Expression increases at the dauer larval stage, compared to the level in the embryo (PubMed:16567400)
+Expressed in the motor neuron progenitor domain of the spinal tube from 11.5 dpc to postnatal day 6
+Expressed in embryos at about the 20-50 cell stage (PubMed:11850401, PubMed:16905130). Expression persists throughout development and into adulthood (PubMed:11850401). Also expressed at lower level in germ cells, developing oocytes and embryos starting at the two-cell stage, before the onset of zygotic transcription, suggesting that the protein is maternally inherited (PubMed:11850401). Expressed in hyp7 hypodermal cells and vulval precursor cells of larval L2 stage hermaphrodites (PubMed:19064713)
+Expression starts at 8 dpc in the developing heart. Higher expression in the brain is detected between 12 dpc and 16 dpc. High levels of expression in dorsal root ganglia and spinal nerves were observed throughout all developmental stages. In later developmental stages expression is more prominent in skeletal systems (at protein level)
+Expressed at the animal pole of unfertilized eggs and throughout cleavage stages in the prospective ectoderm germ layer. Expressed at the animal pole and extending up to the marginal zone at blastula stage. At the onset of gastrulation remains asymmetrically enriched in the dorsal side of the early gastrula. Its expression progressively diminishes as gastrulation proceeds (at protein level)
+Detected throughout the embryo, covering all stages of development from pre-globular to torpedo stages. Also detected in the suspensor and endosperm
+Expression peaks at G2/M phase and is low in G1 phase. Expressed at higher levels in immature erythroblasts relative to mature erythroblasts
+Expressed predominantly during embryogenesis. In myogenic progenitor cells, expressed during early myogenic development (11.5 dpc) to be gradually down-regulated during the fetal stages (17.5 dpc) (PubMed:27446912)
+Constant levels during the development of leaves
+Expressed weakly in 4-8 hours embryos, more abundant expression in 8-12 hours and remains throughout later embryonic and larval stages
+At 12.5 dpc, expressed in the metanephric mesenchyme. At 16.5 dpc, expressed in the condensing metanephric mesenchyme surrounding the ureter tips. At 18.5 dpc, expressed in whole kidney
+Expressed specifically during the development of the nervous and muscular system
+Isoform E12 and isoform E47 are present at all the stages of development and in all regions of the embryo
+Expressed in touch receptor neurons and several neurons in the head, tail and ventral cord during larval development
+Barely detectable at 15 dpc, increased after birth to reach a maximum at P15
+Expressed both maternally and zygotically. Expressed in unfertilized eggs and at blastula stages. Expression remains relatively high until late gastrula stage (stage 11) but becomes weaker at early neurula stages (stages 12 to 15). Expressed strongly at stages 18, 20 and 30
+Detected in fully grown, germinal vesicle (GV)-intact oocytes and in oocytes at the metaphase II stage, with levels decreasing thereafter (at protein level) (PubMed:15899864). Detected 1 week after birth in developing ovary (PubMed:27663720). Detected at 17.5 dpc, with levels increasing thereafter (PubMed:17567914)
+Constitutively expressed at low level throughout development (at protein level)
+Expressed in early embryos, late embryos, late third instar larvae and adults
+Expressed continuously throughout development. Low expression (at protein level)
+In an in vitro model of myogenesis, not detected in proliferating myoblasts. Hardly detectable during the first days of differentiation. Expression greatly increases in mature myotubes
+In germinating seeds, present in the root tip and in a linear array of up to 20 to 30 cells above the root tip. Weak expression in the vegetative shoot apex. High levels in primordial leaves. Strongly expressed in the inflorescence apex, and, to some extent, in the inflorescence stem, the vascular tissue, and the vascular tissue in leaf primordia. In the gynoecium, confined to ovules. In developing anthers detected in developing locules of immature anthers and later, at low levels, in pollen grains (PubMed:11743113). In flowers, expressed in sepals, style, receptacle, anther filaments, especially in young anthers, and connective but not in anthers themselves (PubMed:15722475)
+In larvae, detected in neuroblasts (at protein level) (PubMed:22357926). In imaginal disks, expressed as follows: in the eye disk, within and posterior to the morphogenetic furrow; in the wing pouch, in the presumptive intervein regions and wing margin; in the leg disk, general expression (PubMed:1427040)
+Expression is increased during the first eight days (anagen) of the hair cycle in male mice, and is low during the quiescent phase (telogen) of the hair cycle. Expression is very low throughout the hair cycle in female mice
+Expression increases in the stationary phase of growth
+Expressed in the dorsal nerve cord of L1 larva and on the dorsal side only of L4 larva and adults
+During flower initiation, expressed in the peripheral zone of the shoot apical meristem. Confined to the anlagen of successive flower buds yet to arise. Later expressed in abaxial and adaxial sepal primordia, but not in sepals. When sepals initiate, localized in the region interior to them. Within the gynoecium, detected in the initiating and developing medial regions, and then in the developing septum and stigma. SPT expression also occurs in sub-regions of developing ovules, and in the wall and dehiscence zone of the maturing fruit. As the petals develop, becomes restricted to the adaxial epidermis. In stamen expression increase in the vicinity of the archesporial cells and in cells undergoing divisions to produce sporogenous and secondary parietal cells of the anther locules. Expressed in the tapetum and microspore mother cells until the initiation of meiosis. Also detected in stomium and filaments
+Embryos, larvae and adults
+Expressed from 7 dpc when yolk sac hematopoiesis is initiated. Between 12.5 dpc and 15.5 dpc restricted to the developing fetal liver and the site of definitive hematopoiesis. Detected in thymus at 15.5 dpc as well as the midbrain, forebrain and the olfactory epithelium
+Accumulates at a high level in endosperm during the period of zein synthesis and protein body development and declines to a low level at kernel maturity
+Regulated in a cell-cycle dependent manner. Weakly expressed in G1 and S phases. Expression increases in G2/M phases and persisting until the end of mitosis (at protein level)
+In embryos, expressed in 20- to 30-cell stage and expression decreases after the 200-cell stage (PubMed:23666922). Expressed in seam cells, intestine cells, pharyngeal muscles and nerve ring neurons in L3 stage larvae and expression persists into adults (PubMed:21471153)
+Expressed in embryos and during larval development up to larval stage L2 (PubMed:20133583). Highly expressed in embryos (PubMed:22548001)
+Not detected in pregastrula embryos. Upon gastrulation, detected in the epidermis and visceral mesoderm. The expression pattern undergoes a pronounced change, such that epidermal expression decreases to background levels while mesodermal expression remains high. Visceral mesoderm expression decreases once formation of the gut tube is complete. Concurrently, central nervous system expression intensifies. Also detected in the peripheral nervous system
+Expressed very weakly in early larvae, levels of expression increase in L4 and adult stages when germ cells are continually proliferating
+Strongly and ubiquitously expressed at early stage of somatogenesis. Later, expression is prominent in the developing retina, optic tectum and somites
+Present in actively dividing cells such as root and shoot meristematic regions, young leaves and stems, inflorescences and siliques
+Detected at several stages during embryogenesis, but only within organs bearing motile cilia
+Expressed both maternally and zygotically. Highest embryonic expression is found during syncytial blastoderm (nuclear cycles 11-12). Expression declines rapidly at cellular blastoderm stage 5 and is not detected during the rest of embryonic development
+Expressed throughout development, highest expression being in adult heads
+Highly expressed in the early embryo. High expression at embryonic day 7 and later in the fetal liver, lung, placenta and kidney
+At 15 dpc embryos, weakly expressed in osteoblasts within the distal area of the ossification center of the mid-shaft region of the ulna and the radius. At 16 dpc embryos highly expressed in mandible, maxilla, frontal bone and ossification regions of the nasal septum. At 17 dpc embryos expression is localized to developing mandibular and maxillar bones, the frontal bones and in the nasal capsule surrounding the nasopharynx. Expression throughout the developing mandibular bone is found in 15 dpc-17 dpc embryos. Present in periosteum of the humerus at 16.5 dpc (at protein level)
+During anther development, expressed from stage 10 to the latest stage 14 in tapetal cells, developing microspores and mature pollen grains and released pollen grains
+Expression increases from oocyte stage I/II to reach its maximum in oocyte stage v/vi in unfertilized eggs, and then progressively decreases to become undetectable at the gastrula stage
+Expressed in the developing neural tube as early as 8.5 dpc. Remains most highly expressed in the developing brain and spinal cord during later development at least until 14.5 dpc. Also detected in the lung, adrenal gland, gut and kidney, particularly the kidney cortex. Undetectable in the liver
+Early blastula until gastrulation, barely expressed during gastrulation and present again from neurulation until late embryogenesis
+First observed in the embryo proper at the four-cell stage. Later expressed throughout the embryo from the eight-cell to the bent-cotyledon stages. Until the torpedo stage of development, mostly concentrated at the root pole. At the torpedo stage, strongest levels in the columella and lateral root cap. Hardly detected in the suspensor. Present in seedling roots. In mature and fully differentiated young roots, accumulates from the root cap to the emerging root hair zone
+At 17 dpc, expressed in the auditory circuit, most prominently in the inferior colliculus, and later in the medial geniculate and the auditory cortex at P0. At P0, also expressed in targets of retinal projections, such as the superior colliculus, the suprachiasmatic nucleus, and the ventrolateral geniculate nucleus. At the same stage, detected in selected structures of the limbic circuit, including the anterior limbic thalamic nuclei, the hippocampus, amygdala and habenula
+First detected at mid-gastrulation. After the onset of segmentation, detected in cranial placode. At later stages of development, detected in the olfactory, otic, and lateral line placodes, in the developing inner ear and in neuromasts. After 48 hpf, no longer detected in the inner ear, but continues to be expressed in lateral line neuromasts. In addition, detected in the pituitary, branchial arches, somites, pectoral fin, ventral abdomen muscle, and the cranial muscles of the eye and lower jaw. Detected in developing fast muscle
+Increases at the transition from G1- to S-phase, and the continues to the end of M-phase. Almost disappears when cells reenter the next G1-phase
+At 7.75 dpc, expression restricted to the ventral node monociliated pit cells. Not expressed in other tissues at detectable levels until 9.5 dpc. At 10.5 dpc, expressed in motor neurons in the ventral neural tube and in the apical ectodermal ridge of lim buds
+At 8 dpc, 9.5 dpc and 16.5 dpc, transcripts from parental allele are detected in embryonic and extraembryonic tissues (PubMed:28522536, PubMed:1997210). At 16.5 dpc, transcripts from parental and maternal alleles are detected only in the choroid plexus and the leptomeninges (PubMed:1997210). Expressed in fetal muscle and brain tissue at 12.5 dpc (PubMed:29440408). Low levels of expression during myoblast proliferation. Levels rise rapidly during myoblast differentiation and then decrease
+Predominant isoform expressed in fetal muscle tissues at 12.5 dpc
+Expressed in the third larval instar and maintained through pupal development. Levels gradually increase during adulthood
+Detected at low levels in sciatic nerve from newborns. Levels increase strongly during the first 3 weeks, and decrease thereafter to reach a low, constitutive level in 4 week olds. Expressed at a low, constitutive level in adults
+Expression begins at embryonic day 20 and increases thereafter. Expression continues into adulthood
+Detected 10 days after birth in pituitary and adrenal endocrine tissues and at a lower level in hypothalamus and atrium (at protein level)
+In carpels, expression starts when the gynoecial primordia becomes distinct. First expressed in the lateral region of each carpel. Later resolves into two distinct domains, epidermal and internal. In epidermal tissues, mostly localized on the outer surface, successively from the base to the tip of the gynoecium and finally confined to the valve region before disappearing during last flowering stages. In internal tissues, first confined to four discrete zones adjacent to the future placental tissue occupying the full length of the elongating cylinder, declining from the apical regions and disappearing after the ovule primordia arise. Before nectaries initiation, expression occupies a ring of receptacle cells between the stamen and sepal primordia, from where nectaries will develop. Strongly expressed in nectaries until latest flowering stages
+Abundantly expressed in cochleae from embryonic day 17 to postnatal day 42
+Expressed in both motoneurons and muscle throughout the period of synaptic growth and development at the neuromuscular junction. Expressed throughout the CNS, including motoneurons. Weak expression is observed in embryonic muscle as well as other tissues. Expressed throughout the larval CNS with pronounced expression in motoneurons. Also strongly expressed in all body wall muscle as well as other tissues, including a subset of epithelial cells and the salivary glands
+Strongly expressed in all types of meristems, including the shoot apical meristem (SAM) and lateral organ primordia. Also detected in the lamina of the cotyledons, especially in the mesophyll and vascular bundles. In leaf primorida preferentially present in vascular strands and at the distal tip of the leaflet. In the floral meristem, first detected in flanking sepal primordia, and later expressed in stamens and carpels in flowers
+Induced during competence (PubMed:11948146)
+Expressed at high levels in vessels from developing heart from 12 dpc to P12. Expression decreases markedly from P12 to P17, and is no longer detectable at P30
+In imbibed seeds, accumulates in cotyledons and hypocotyls. In flowers, expressed in the filament of stamens, in the style, and in ovary with eggs of pistil
+Up-regulated during seed development
+Expressed ventrally in early gastrulae (stage 10.5) and is expressed most strongly in the outer layer of ectodermal cells. At the late gastrula stage (stage 12), expression appears to be up-regulated consistently in a small group of cells clustered around the ventral edge of the closing blastopore. At the early neurula stage (stage 13), four regions of ectodermal expression are clearly detected. At stage 19 (late neurula), expression persists in the cement gland, the ventral epidermis, the proctodeal region, the lens placodes, and in a broad placodal area caudal to the eye anlagen. In addition, expression also detected in the dorsal root ganglia of the future spinal cord. At stage 21/22, expression seen in a wishbone-shaped group of cells situated dorsal and caudal to each developing optic vesicle corresponding to the cranial (profundal and trigeminal) ganglia. Expression persists in these cells through tail bud and into early tadpole stages. From stage 21/22 onward, the bilateral expression in the ectodermal placodes becomes restricted primarily to the otic placode and the developing otic vesicles. At stage 24, also observed in the precursors of the hypaxial muscles and the pronephric duct in the trunk, in the developing branchial arches and in the primordium of the heart. In stage 29 embryos, expression detected in the frontonasal process and continues to be expressed in the same regions of the embryo at stage 33, although its expression becomes clearly regionalized in the looping heart. A higher level of expression seen in the ventricle as compared with the atrium
+Expressed during anther development
+Expressed maternally. Expressed zygotically throughout development from the mid-blastula transition. Expression is concentrated in the head and trunk region of the embryo at the pharyngula stage of development
+Highest levels in early embryo (0-2h) and adult stages
+Present in fetal thymus at 14.5 dpc. Expressed during thymocyte maturation, the expression being highest in CD4(+)CD8(+) thymocytes and decreasing with maturation
+Levels decrease during embryonic brain development (PubMed:9454838). Expressed during postnatal days P3 to P60, with an increase in expression at postnatal day P14-P15 (PubMed:22960932). Increased abundance in the nucleus at P14-P15 relative to P9 (PubMed:22960932)
+First observed during the transition from the late globular to the early heart embryo stages. Later observed during heart, tropedo, and cotyledonary embryo stages. In seedlings, observed in the shoot apex and stomatal guard cells. In adult plants, expressed in inflorescences. In flowers, strongly present in styles and pollen grains
+Expressed throughout apical and vegetative meristem during development. Down-regulated as leaves and floral organs are initiated
+Transcripts are first detectable at stage 13 or 14 (PubMed:8229205). The expression is restricted to the nervous system, becoming quite robust in both the central and peripheral nervous system (CNS and PNS, respectively) by late embryogenesis (PubMed:8229205)
+Expressed in the embryo from late gastrulation onwards (PubMed:31988188). Broadly expressed during embryogenesis with high expression at the presumptive nose during the 1.5-fold stage of embryogenesis (PubMed:27623382). Expressed in AWB sensory neurons in larvae and in PHA/PHB tail neurons at the L1 stage of larval development (PubMed:27623382)
+Expressed exclusively in meiotic prophase cells
+Normally not expressed. Its expression is induced when that of thrS is reduced
+This soluble protein is present in abundance in the adult worm as well as in the schistosomula and the eggs
+In the developing hippocampus, the expression of isoform 1 is high at P8, then decreased with progression of hippocampal development. Isoform 3 expression was constitutively low, and not regulated during hippocampal development
+Highly expressed in the unfertilized egg. Expression is reduced at the two cell and blastocyst stages. Expressed in the liver, CNS and dorsal root ganglia throughout organogenesis. Also expressed in the intestine, kidney, lung, nasal cavities and thymus from 13 dpc
+Expressed during embryogenesis and in mature plant
+Ubiquitously expressed in the second and third segments of the pupal antenna (at protein level) (PubMed:27331610). In the eye imaginal disks of 3rd instar larvae, expression is highest in the morphogenetic furrow (PubMed:27195754)
+Expressed in fetal brain (PubMed:15645143)
+Larval brain (at protein level)
+Expressed in different patterns throughout embryogenesis (at protein levels) (PubMed:30260959, PubMed:30567930). At stage 11/12, embeds dorsal median cells and somatic myoblasts forming a thin layer between the ectoderm and the mesoderm and around the prospective anal plate (PubMed:30567930). At stage 12, after germ band retraction, accumulates in the forming basal membranes around the developing brain and ventral nerve cord, in the differentiating tracheal system, in the future digestive tract as well as in the forming somatic muscles (PubMed:30567930). At stage 13, accumulates around caudal visceral mesodermal cells (PubMed:30260959). At stage 16, expressed in the basal membrane surrounding most tissues, including muscles, gut and larval ventral nerve cord, brain, and in chordotonal organs (at protein level) (PubMed:30260959, PubMed:30567930). Expressed in embryonic macrophages (at protein level) (PubMed:30260959). In the larva, expressed mainly by fat body adipocytes and blood cells in the basal membranes that surround the fat body, imaginal disks, tracheae, salivary glands, midgut, mature muscles and heart (at protein level) (PubMed:30260959). Expressed during embryogenesis: at stage 11/12 detected in single cells of the head, especially in the gnathal segments as well as in segmentally located patches of cells in the dorsal mesoderm, detected in the midline-associated, mesodermal dorsal median cells and somatic myoblasts (PubMed:30567930). Only low expression in the amnioserosa (PubMed:30567930). After germ band retraction (stage 12), expressed in the forming dorsal and ventral muscles, the amnioserosa and the segmentally located chordotonal organs (PubMed:30567930). Expressed in the esophageal visceral muscle primordium and in the joint region between hind- and midgut (PubMed:30567930). At stage 16, expressed in somatic and visceral muscles, and in the cap cells of the chordotonal organs (PubMed:30567930)
+Gradually accumulates during seed maturation and reaches maximum levels in dry seeds. Fades progressively upon germination
+Detected in cardiac progenitor cells with expression levels increasing as progenitor cells differentiate into cardiomyocytes
+Expressed at very low levels during embryogenesis
+Expressed during parasite asexual blood stages (at protein level)
+Expressed both maternally and zygotically. Expressed during embryonic, larval, pupal and adult stages. Weakly expressed in the male and female body and correspondingly low levels during early embryonic stages. Significantly expressed from embryonic stage 8-12 hours and reaches maximal levels in the pupae and male head
+Present at low levels even in etiolated seedlings, expression increases in both bundle sheat and mesophyll cells upon greening
+During development expression peaks in embryos, decreases sharply in L1 larvae and then remains low throughout larval development
+Expressed in the ventral spinal cord, with strong expression in a subset of motor neurons, and in a subset of sensory neurons at embryonic day (E) 15.5 (PubMed:25826454). In the developing brain, expressed at low levels on 11 dpc, rapidly increasing to peak at postnatal day (P) 1, a period corresponding to the early stage of postmitotic neuronal differentiation when neuronal morphogenesis or synapse formation occurs, and then gradually decreasing (PubMed:27683913)
+Expressed in 7-day-old embryos with levels then falling to very low or undetectable amounts. Not detected in adult
+In larvae, expressed in primary neural precursors (at protein level) (PubMed:1427077). In leg imaginal disks, expressed in stripes at the distal edge of each leg segment primordium (at protein level) (PubMed:1427077). In stage 9 embryo, detected in the first neuroblasts delaminating from the ectoderm (at protein level) (PubMed:22357926). In newly hatched larvae, detected in dividing neuroblasts (at protein level) (PubMed:22357926). First detected in preblastoderm cycle 12 in all nuclei (PubMed:1427077). During middle to late cycle 13, expressed in eight stripes that overlap those of the hairy protein (PubMed:1427077)
+Expression increases during skeletal muscle cell differentiation
+Expressed both maternally and zygotically throughout development and in adult hermaphrodites and males (at protein level)
+Expressed during the syncytial endosperm development
+During floral development, accumulates to highest levels during open flower stages
+Primarily detected in migrating neural crest cells and their derivatives during embryogenesis
+Expressed in the procyclic and bloodstream stages (at protein level)
+Expressed in condensed prechondrocytic mesenchymal cells and in early chondrocytes of cartilage primordia. Expression is lower in mature chondrocytes
+Expressed at equal levels in the yeast or hyphal form
+During early and mid-gestation, dbx expression is restricted to the telencephalon, diencephalon, dorsal mesencephalon and spinal cord. At later gestational stages, dbx expression continues in the dorsal mesencephalon and diencephalon, in which expression is more restricted than at the earlier stages
+Expressed both maternally and zygotically, low expression is present in males, larvae and pupae
+Abundant throughout oogenesis and embryogenesis, decreases during larval stages and increases again in pupae
+Strongly expressed at the early stages of germination upon testa rupture and throughout seedling development. Accumulates in the cotyledons and foliar primordia. In seedlings, highly present in almost every organ except the root meristem and secondary root primordia. In young leaves, detected in the trichomes. In mature leaves, present in the vasculature as well as in the pedicel and base. In flowers organs, mostly expressed in stigma, petals, anthers and pollen. In developing siliques, restricted to pedicels and septum
+Expressed at 17.5 dpc
+Expressed both maternally and zygotically in embryos, pupae and adults. Expression is highest in embryos
+Expression is first detected in the marginal zone of the vertebral primordia at 12.5 dpc. Expression is subsequently observed during skeletal development in the cartilaginous elements including the vertebral bodies, carpal bones, femora, ribs and caudal vertebrae. At 18.5 dpc, expression is increased in the layers of proliferating and prehypertrophic chondrocytes. Furthermore, expression is also observed in intervertebral disk, including nucleus pulposus and annulus fibrosus, during skeletal development
+Highly expressed in the CNS of embryos from day 7 to 17
+During the stages 11.5-13.5 dpc it is expressed in most embryonic tissues. Within the telencephalon, it is predominantly expressed inside the ventricular zone where expression reaches its peak at 15.5 dpc and starts to decrease by 18.5 dpc. Expression is also observed in mitotically active cells outside the telencephalon, but not in adult brain
+At 13.5 dpc, expressed in most embryonic tissues and in placenta. At 14.5 dpc, expressed at high levels in a variety of muscle tissues, including that of the face and trunk, the intercostal muscles, the diaphragm and cardiac muscle, the tongue and limbs (at protein level). In the brain, most abundant expression in the subependymal layers, in the meninges and in the choroid plexus (both epithelium and mesenchyme) (at protein level). High levels in the liver, bronchioles and the cartilage of the atlas, ribs and long bones (at protein level). In the kidney, expression limited to the developing tubules and mesenchyme (at protein level). Also detected in the adrenal gland and pancreatic bud (at protein level). At 12.5 dpc, paternal allele expression detected in the cartilage of the limbs, ribs and face and in the meninges. At 14.5 dpc, paternal allele expressed in the cartilage of the axis, ribs, head, and long bones, in the heart, lungs, gut, umbilicus and tongue, as well as in the meninges of the fourth ventricle. Not detected in the skeletal muscle. In most tissues, paternal expression is lower than maternal
+Expressed from mid-blastula
+Expressed in high amounts at the onset of limb cartilage differentiation
+Overexpressed in CD34-positive erythrocyte progenitor cells in acute myeloid leukemia. Down-regulation correlates with hematologic remission following chemotherapy
+Highly expressed in parasitic larvae (cercariae) and at a lower level in eggs, miracidiae, schistosomulae and adults
+Observed in emerging secondary roots and young leaves. During flower development, restricted to carpels, stamen filament, and the abscission zone of the floral whorls
+Highest expression was found at 11.5 dpc, and expression rapidly declines at later stages of the development. Between 8.0 and 13.5 dpc is found in neural crest cells during their pre-migratory, migratory, and, in some cases post-migratory phase throughout the body axis. Also found in lateral mesenchyme of trunk and head. At 10 and 12 dpc found in mesonephric tubules. At 16 dpc found in epithalial cells of metanephric 'comma' and 'S'-shaped bodies, in mesenchymal cells of the medulla and the cortex. Colocalized to the nucleus of glomerular podocytes and epithelial cells lining many of the convoluted tubes. At 10.5 dpc found in both the anterior and posterior of the limb bud. At 11.5 dpc expression becomes increasingly peripheral, extending around the entire handplate in the mesenchymal cells underlying the apical ectodermal ridge. At 12.5 dpc expression is entirely peripheral an by 13.5 dpc is localized to the mesenchyme at the distal tips of the digits. At 10 dpc found in cells of the optic cup and in some cells surrounding the eye. At 12 dpc found in developing lens fibers, the ectoderm overlaying the developing eye and less intensely in the retina. At 12 dpc found in cells of the dorsomedial and dorsolateral epithelium of the otic vesicle. At later stages expressed in only a few specialized cell types of the cochlear duct, including the inner and outer hair cells, stria vascularis, and the mesenchymal cells directly underlying the organ of Corti. From 10.5 to 12.5 dpc expressed in the telencephalon including the olfactory bulbs, throughout the length of the neural tube and within the dorsal root ganglia, in cranial ganglia in the trigeminal ganglion and the glossopharyngeal-vagal ganglion complex. At 10.5 and 11.5 dpc expressed in punctate pattern on the ventral side of the embryo between the fore and hind limbs, the rib primordia; this expression disappears by 12.5 dpc. At 11.5 and 12.5 dpc found in genital eminence
+Detected at high levels in 7 dpc mouse embryos; its level decreases at later developmental stages and in adult tissues
+During embryogenesis, it is highly expressed at the dorsal neuroepithelium flanking the roof plate
+Expressed in all cells of the young ovule primordium at pre-meiotic stages, including the L1 layer. At early stages of female gametogenesis, expression is restricted to the distal (micropylar) portion of the developing ovule, but is absent from the 1-nuclear female gametophyte. In fully differentiated ovules, expressed at the proximal and distal poles but not in the female gametophyte
+First expressed upon invasion of the mammalian host
+Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis
+At 8.5 dpc, expressed predominantly in neural tube and somites. At 9.5 dpc, expression is higher in the peripheral region of the brain, in the dorsal region of the neural tube, in the segmental plate and in the somites. In developing brain, expression is restricted to regions with actively proliferating cells. At later stages, expressed in many tissues of neuroectodermal and mesodermal origin. At 17 dpc, expression is high in the skeletal muscle fibers, which are mitotically arrested and terminally differentiated
+Plasmodium specific alpha 2-tubulin
+Expressed during fertilization, while it is repressed during seed development
+Expressed in 4th-instar larval midgut, in the brush border membranes of the gastric cesum and the posterior stomach cells (at protein level)
+Exclusively expressed in spermatids. Not present in mature sperm. Localized with both the manchette and the axoneme in step 10-11 spermatids. Detected on manchette microtubules of step 12 spermatids. Associates with the tail in steps 18-19 spermatids and epididymal sperm
+Localizes to the posterior pole of the oocyte during stages 1-9 of oogenesis, where it colocalizes with mago
+During embryoid body (EB) formation, expression peaks at day 1 of EB differentiation (at protein level) (PubMed:29804889). Expressed during embryonic stem cell differentiation in vitro, with high expression during the earliest time point of differentiation during a 'poised' pluripotency phase that occurs in between embryonic day 4.5 and embryonic day 5.5 (PubMed:26255770, PubMed:29804889)
+Expressed in promastigotes (at protein level)
+Expressed in all cells of embryos from the 26-cell stage (PubMed:10375507, PubMed:11907270). Then, it is ubiquitously expressed throughout the development (PubMed:10375507, PubMed:11907270). Not expressed between fertilization and the 26-cell stage (PubMed:11907270)
+Associated with differentiation of the endodermal tissues
+Weakly expressed at day 18 p.p. and increased expression at day 21-25 p.p. with increasing spermatid numbers
+Expressed from the one-cell embryo to the adult (at protein level)
+Present at 10.5 dpc (at protein level)
+Expressed throughout the growth cycle
+Detected only in male adults
+Expression levels peak at 4 hours of development after which they decrease steadily. Undetectable after 20 hours of development
+According to PubMed:10864955 is expressed during retinal development by 14.5 dpc throughout the RGC layer, and is clearly restricted to the inner nuclear layer at 17.5 dpc. In the developing optic chiasm is strongly expressed at 12.5 dpc at the ventral midline of the diencephalon in the region in which the RGC axons enter the brain and turn to grow ventrally, the region expression includes the position of the glial knot. At 14.5 dpc expression is maintained at the ventral midline of the diencephalon, in a region directly dorsal to the site of axon divergence. Outside the developing brain. According to PubMed:10433822 prominently expressed in neural and mesodermally derived tissues. From 8.5 dpc to 9.5 dpc expressed strongly in the roof plate, floor plate, and notochord. Beginning at 10.5 dpc intense expression is also observed in the motor columns. By 13.5 dpc the expression decreased in the roof plate but is still retained in the floor plate and motor columns. In the rostral CNS between 8.5 dpc and 9.5 dpc expressed intensely in the dorsal neuroepithelium overlying the hindbrain, in the dorsal midline of the midbrain and forebrain, and in the ventral midbrain region. By 10.5 dpc to 11.5 dpc, additional intense expression is observed in the rhombic lip and the rostral midline. From 13.5 dpc to 17.5 dpc, the expression decreased dorsally and continued to be detected in the ventral mesencephalon and diencephalon. Outside neuronal development expressed between 8.5 dpc and 9.5 dpc in the clefts between the first, the second, and the third branchial arches. From 10.5 dpc to 11.5 dpc, expression is detected in the nasal pit, the developing eye, the otic vesicle, and the visceral grooves. From 13.5 dpc to 17.5 dpc expressed in the developing cochlea (in a pattern consistent with expression in the organ of Corti), in the olfactory epithelium and in the inner neuronal layer of the retina and in the optic nerve. At this stage also expressed in the tongue, in the tooth primordium, and in the outer root sheath of the whisker follicle in the layer surrounding the bulb. At 11.5 dpc is intensely expressed in the rostral lateral ridge flanking the forelimb buds and in lateral ridge tissue between the fore- and the hindlimb buds. Weak expression is observed in a segmented pattern in the posterior part of the sclerotome. Expression is notably absent in the base of the limb buds and weak expression is observed in the interdigital regions of the distal limb bud beginning at 11.5 dpc. By 13.5 dpc intensely expressed in interdigital mesenchyme
+Expressed at relatively high levels in vegetative cells. The expression goes down at the 2th hour of development and increase slightly up to the 8th hour, it then goes down until the 12th hour where it increase gain to reach a maximal value at the 16th hour
+Expressed both maternally and zygotically. Detected at two-cell stage. Ubiquitously expressed from the shield stage to 24 hours post-fertilization (hpf), and then becomes preferentially expressed in the central nervous system. From 5 days post-fertilization (dpf), expression becomes detectable in the gut and pronephric duct epithelium
+Expressed in tapetum during the tetrad stage
+Expressed in the developing forebrain and also in the floor plate (PubMed:9256348). Expressed in the interstitium of the male gonad at 14.5 dpc, but only weakly in a region of the female gonad proximal to the mesonephros (PubMed:12379852)
+Expressed in proheterocysts (at protein level)
+Expressed in embryos from stage 11 and in larvae
+First detected at germinal vesicle breakdown in maturing oocytes (at protein level)
+Strongly expressed in the prespore region of aggregates but not in the anterior prestalk zone
+Detected in the axial mesoderm at 9 hours post-fertilization (hpf). Expressed in the central nervous system, somites, notochord and developing pronephric duct at 18 hpf. At later stages (48-72 hpf) expression decreases in the trunk but persists in the central nervous system, and is also found in liver and kidney primordia
+Expressed in the coelomic epithelium and within some mesonephric tubules of the genital ridge at 10 dpc. Expressed during kidney development
+Initially detected at 14.5 dpc in the mesenchymal cells of the brain. Later in development, observed in the choroid plexus and within single cells in the brain
+Accumulates transiently in germinating seeds (at protein level) with a constant transcript level (PubMed:14671017, PubMed:17283014). Abundant in cotyledons during post-germinative growth and in sink tissues, such as young leaves, developing flowers, siliques and seeds (at protein level) (PubMed:17283014). In flowers, present in the nectaries, stigma, endocarp of the fruit wall and in tissues involved in the transfer of assimilates to the developing ovules and seeds, such as the vasculature and seed coat (at protein level) (PubMed:17283014)
+Detected in all embryonic germ layers, in the extraembryonic yolk sac blood islands and in the fetal components of the developing placenta. As development progressed, expression is dramatically restricted
+Expressed both maternally and zygotically. Zygotic expression is restricted to adult females
+Present throughout development. Most abundant in embryos, pupae and adult females
+It is present in young cotyledons at 14 days after fertilization (daf) when cells are still rapidly dividing. Levels steadily accumulate until 30 daf and with the beginning of the seeds desiccation phase at 50 daf the levels decrease to very low levels
+Expressed in Kupffer's vesicle
+Highly expressed in the dental sheet, oral epithelium, and mesenchyme at 12.5 dpc; in the tooth germ bud, ectomesenchyme and oral epithelium at 13.5 dpc; and in the dental papilla and dental epithelium at 14.5 dpc
+Developmentally regulated with significant expression beginning at 18 dpc and rising just before birth
+Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types
+High expression in the earliest stage of silique development, with a decrease during the middle stages of silique development and subsequently an increase during the later stages
+Secreted in fetal fluids. Present on day 25, decreases from days 30-39, and disappears by day 50. Expressed by blastocysts on days 10-25 during prenatal development, but disappears by day 50
+Low levels are present in newborn rats and up to day 6. Subsequently, levels increase strongly. Adult levels are detected starting from day 9 in the basal turn of the cochlea, from day 10-11 in the middle turn, and from day 12 in the apical turn
+Expressed strongly throughout the yolk. Later, zygotic expression is confined to the presumptive neurogenic regions. In the CNS, expressed in the ventral nerve cord. Expressed in the PNS including in the lateral chordotonal organs at stages 16-17, expressed in epidermal cells at stages 13-15, and expressed in heart cells at stages 13-17
+Expressed in 4 to 24 week old mice
+SP4 gene is transcribed in or before primary spermatocyte stage but is translated at the round spermatid stage
+Abundant in unfertilized eggs. Not detected in late gastrula or early neurula stages. Expressed in mid-neurula stages and maintained through tadpole stages
+Expressed at low levels during embryonic development
+During embryo development, expressed in the basal part and the vasculature of heart stage and torpedo stage embryos
+Weakly expressed at ZT8.5 and highly expressed at ZT14.5 at P6. At P6 highly expressed at ZT14.5 in hippocampus, prefrontal cortex and cerebellum. First detected and widely distributed at P1 and that continued throughout postnatal development. Expression is evident in the cortical plate (CP) at 17 dpc. Lower levels of expression is also evident in intermediate (IZ) and subventricular (SVZ) zones at this age. A more diffuse expression pattern is evident in early postnatal cortex with only slight differences in intensity throughout cortical layers. By P14, a more laminated distribution pattern becomes evident with a punctate distribution apparent in deep cortical layers
+Expressed only in male hamsters
+Follows the pattern of expression of interferon tau by the conceptus. First appears on day 15 of pregnancy in endometrium of cows, reaches a maximum on day 18 and remains high through day 26
+Expressed in embryos. Expressed from blastoderm embryos. Not expressed in first and second instar larvae. Weakly expressed in third instar larvae. May be weakly expressed in adults
+Expressed in diencephalon, mesencephalon, anterior hindbrain and otic vesicles at 24 hpf
+Preferentially expressed during vegetative growth and in the earliest stages of development. Expressed at significantly lower levels during later stages of development
+Restricted expression during development with expression in the pronephros and ventral mesenchyme at 24 hours post fertilization (hpf). By 36 hpf, expression is detected in discrete zones along each somitic boundary, between the PCV and the horizontal myoseptum, as well as along the horizontal myoseptum itself. At 48 hpf, expression is restricted along the horizontal myoseptum
+Detected at 1 to 7 days post-fertilization (dpf). Expressed in the forebrain and midbrain at 1 dpf, where it localizes to the ependymal cell layer of the dicephalic ventricle and midbrain ventricle. Expressed in the developing otic vesicle at 2-7 dpf, where it shows particularly strong expression in the epithelium of the semicircular canal projections
+In fetal tissues, it is more abundant in kidney and lung
+Isoforms are expressed differently during development, while isoform 2 is preferentially expressed in eggs, isoform 1 is preferentially expressed in the adults
+Isoforms Z1 accumulate slowly in mid instar larvae salivary glands at beginning of ecdysone response (94-114 hours of development at puff stage 1) and become the predominant isoform after 6 hours. Levels diminish at puff stage 2 and are moderately abundant in late larvae from stages 3-10. In prepupae, transcripts appear at puff stage 15 onwards, reaching maximum at stages 18-20. In gut, levels remain constant between stages 1-11. In Malpighian tubules, Z1 isoforms are seen at stages 3 and 7, but not at stage 11. In fat body and wing disks, low levels increase between stages 3 and 11. Isoform Z2 accumulates to a high level at the beginning of the ecdysone response during puff stage 1 and abruptly disappears after several hours. In prepupae, transcripts are reinduced at low levels. Low levels are seen in the Malpighian Tubules, gut and fat body between stages 1-11 and high levels in the wing disk. Isoform Z3; in mid instar larval salivary gland transcript accumulates to a high level at the beginning of the ecdysone response, 94-98 hours of development in puff stage 1, and abruptly disappears after several hours. Levels increase by puff stage 3 remaining abundant in late larvae until stage 10, then diminish by stage 11. In prepupae, transcripts are abundant and increase during puff stages 11-14 and 18-20. High levels are seen in Malpighian tubules, gut and fat body between stages 1-11 and low levels in wing disk
+Expressed in all larval and adult stages but not in pre-hatching embryos
+Expressed throughout the epiblast at the onset of gastrulation and in somites, the neural tube and gut at later stages of development. In the developing kidney is expressed in the ureteric bud/collecting duct epithelium
+Expressed in the embryo throughout post-implantation stages with the most prominent expression in the developing CNS. In the adult, it is highly expressed in brain whereas weaker expression can be detected in other organs
+Expressed in dorsal and ventral parts of the lateral, basolateral and basomedial amygdala at 17 and 18 dpc (at protein level). Initially expressed in embryo at 11 dpc, with persistent expression in the nervous system until birth
+In contrast to mice, transcripts are undetectable in the oocyte and during the earliest stages of embryonic development, increasing only after zygotic genome activation
+Expression is higher in 2 and 3 week old rats and lower in adults
+Ubiquitously expressed at low levels during the mitotic cell cycle
+At 17 weeks of gestation, strongly expressed in hepatic erythroblasts. At that stage, also expressed in fetal splenic plasma cells and in lymphatic vessel of fetal peritoneum. In vitro, up-regulated during the erythroid differentiation of CD34+ cells from healthy donors (at protein level)
+At birth, is detected at the interface between the developing neuroretina and the retinal pigment epithelium (RPE) layer. In the postnatal retina (P20) detected in photoreceptors, with particular concentration in the region of plasma membrane evaginations at the basal part of the outer segment (OS). Expressed by rod and cone photoreceptor cells, most abundantly between the OS and inner segment (IS), in close proximity to the connecting cilium
+Highly expressed in newborn spinal cord but hardly detected in the cerebellum compared to adult. Expressed at postnatal day 1 in ependymal cells lining the central canal of spinal cord and in motor neurons. In adult, expression decreases in ependymal cells and increases in motor neurons. The number of positive interneurons decreases but the individual interneuron expression increases in adult spinal cord compared to newborn
+Mostly expressed in mature male strobili and present at high levels in mature and developing female strobili
+Expression is initiated around the second hour of sporulation and continues throughout development. May be expressed predominantly in the mother cell
+Constitutively expressed throughout development
+Expressed in both male and female gametophytes, at the zygote stage, in the endosperm, and during early embryo development. Observed in cotyledonary embryos and in the basal part of the embryo, but not in the suspensor or in mature embryos. Also expressed during somatic embryogenesis
+Expressed constantly during oogenesis from the previtellogenic (stage I) oocyte to the mature (stage VI) oocyte, and after fertilization until the early tadpole stage
+Maternally and zygotically expressed. Zygotic expression increases after gastrula stage. Expressed predominantly in the endoderm
+Highly expressed in the earlier stages of fetal development, expression decreases dramatically by the time the pre-pubertal prostate buds are developed (36 weeks)
+Expressed during apoptosis in thymocytes
+Abundantly expressed from the blastula period through early gastrulation. During early somitogenesis, transcripts are dorsally localized at the level of the segmental plate and the presumptive notochord. At the 18-somite stage, expression becomes largely detectable throughout the somitic tissue At late embryonic stages, expression is particularly evident in the tectum, cerebellum, hindbrain region, and eyes. After hatching, transcripts can also be detected in the myotomes and pectoral fins
+Highly expressed in embryos and to a lesser extent in adults (PubMed:8242740). Expression is low throughout the larval stage (PubMed:8242740). Expressed in all cells, except intestinal cells and their precursors, starting at around 100-150 minutes post-fertilization and continuing throughout the comma stage of embryogenesis (PubMed:17329362). Not expressed after the 3-fold embryonic stage, and only expressed in 2-3 cells in larvae and adults (PubMed:17329362). In males, expressed in the tail at the L4 larval stage (PubMed:17329362). Expression in the tail-spike cell is restricted to the 3-fold embryonic stage prior to the tail-spike cell death (PubMed:17329362)
+First expressed at stage 10.5. Expression increases during neurula stages and remains at least to tadpole stages
+Expressed throughout all development stages
+Expressed from 5 days post-fertilization onwards
+Expressed in trophozoites
+Expressed in both hermaphrodites and males at the L4 stage in the head, body wall muscle cells and tail
+Sequentially activated during the process of meiosis and spore formation
+Not detectable in unfertilized oocytes. First detected in zygotes and the 2-cell stage embryos. Expressed until at least the early blastocyst stage
+In the developing brain, expressed as early as 10-13 dpc. Expression level peaks at 18 dpc and gradually decreases afterwards. Expressed in developing somatostatin-positive basket cells
+Expressed on the surface of motile cells and pioneering axons (PubMed:8861903). Expressed at the onset of gastrulation (at about 100 minutes (min) after first cell cleavage) on the surface of all cells, and then gradually diminishes (PubMed:8861903). Highly expressed in the neurula (at about 400 min), on ventral cord motorneurons, including cell bodies and axons, undergoing axonogenesis (PubMed:8861903). Expressed in stage L1 larvae in ventral epidermoblasts as they undergo planar movements within the epithelium and in neuroblasts QL and QR and their descendants as they migrate longitudinally along the epidermis (PubMed:8861903). Expressed in L2 and later stage larvae in distal tip cells (DTCs) of hermaphrodites as they migrate along the body wall (PubMed:8861903). Expressed in the DTCs beginning at the time of the ventral-to-dorsal second migration (PubMed:11454756). Expression on the immature hermaphrodite specific neuron (HSN) is localized to the ventral surface beginning at the early L2 stage (PubMed:16520734)
+Expressed in the retinal pigment epithelial layer at 18 dpc and in blood vessels of the developing retina (at protein level). Expressed in cells lining the fourth ventricle and central canal of the spinal cord at 17 dpc (at protein level)
+Embryos at gestational age 12.5 dpc show the weakest SLC10A7 expression, mainly in the heart trabeculae of the developing heart and the cartilage of the vertebrae. From 14.5 dpc onwards, expression becomes more ubiquitous, with the strongest level observed at 16.5 dpc and postnatal day P0. At 14.5 dpc, it is strongly expressed in cartilaginous structures in the mandible, in the epithelial compartment of cap stage teeth, in the digits, in the spine and in the lung. At 16.5 dpc, transcripts are mostly localized in the inner dental epithelium and in the epithelial loop of bell stage teeth. At 18.5 dpc expression is observed in the inner dental epithelium of incisors, and in ameloblasts and odontoblasts of molars. At postnatal day P0 there is strong expression in the papillary layer of the oral mucous membrane underneath the palate, as well as in the ameloblast layer of emerging teeth. At postnatal day P10, it is localized to the growth plate of several long bones, such as the forefoot digits, the hindfoot tarsals and the humerus, and expression is more intense in the chondrocytes of the hypertrophic zone
+Expression levels increase through the cell cycle to peak in the mid/late-S phase and decrease during G2/M phase
+Detected at 12 dpc and found at markedly increased levels at 15 dpc and 18 dpc in both the head and the body. At birth the level decreases significantly
+Expressed in pstAB cells and in pstA cells, pstO cells, upper and lower cups, and stalk during culmination
+Expressed in eggs and larval cuticles (at protein level) (PubMed:10066809, PubMed:4197814, PubMed:4197815, PubMed:7981662). Expressed in larval hemocytes and salivary glands (PubMed:10066809)
+Expressed in the hemolymph of larvae and adults
+Expressed in the developing germ line and throughout embryogenesis and the L1-L4 larval stages
+Expressed in sporulating cells. Disappears after 90 minutes of spore germination
+Expression is first detected at 17 dpc in spinal cord and starts in forebrain at birth. Higher expression in brain is detected at postnatal day 15 and persists throughout adulthood
+Expressed both maternally and zygotically throughout development, lowest levels are in third larval instar and pupae
+Expressed in extravillous trophoblast (at protein level)
+Gradual reduction of expression as the first leaf develops. 90% reduction of expression at day 20 after imbibition
+Similar expression at all development stages (14.5 dpc, 17.5 dpc, newborns and adults)
+Expression in the head and thoracic muscle starts during embryonic development and levels continue to accumulate after the nymphs are born (at protein level)
+Specifically or prominently expressed in mouse blastocysts compared to 4-cell stage embryos
+Not expressed until 11 days in embryonic development
+Expression begins in 1 week old mice
+Maternally expressed and distributed during the syncytial blastoderm stage. In zygote first detected in mid-embryogenesis in the developing tracheal system and later in the developing gonad. Tracheal expression is highly dynamic. At stage 11, weakly expressed in all tracheal cells. During stages 12 and 13, preferential expression in the leading cells of the ganglionic branch and other growing primary branches. During stages 14 and 15, expression becomes further restricted to just the GB1 terminal cell and other terminal cells
+Not expressed in the inflorescence meristem or in the flowers at stages 1 and 2. First expressed in the precursor cells of petal primordia in stage 3 flowers and in the developing petal primordia up to stage 6. Not expressed at later stages
+Detected at 17 dpc of embryonic development in a subpopulation of early hypertrophic chondrocytes in bone, but not when fully differentiated
+Sporangium formation
+In developing seeds, accumulates in embryo cotyledons during late maturation, from the torpedo to the green cotyledon stages. Also present in endosperm
+During spermatogenesis, expressed in the testis in all male germ cell stages except elongated spermatids (at protein level) (PubMed:23717213). Highly expressed in fully-grown germinal vesicle oocytes and modest expression throughout the preimplantation stage with a slight down-regulation at the 2-cell stage (PubMed:31827135). In the embryo, expressed at embryonic days 7, 11, 15 and 17 with the highest expression at embryonic day 11 (PubMed:11747609)
+Maximum expression found during days 4 to 6 and days 4 to 14 after inoculation with an avirulent and a virulent pathogen respectively
+First detected at the shield stage of gastrulation in the involuting mesendoderm with levels being highest in the paraxial mesoderm and decline laterally to become undetectable in the ventral mesoderm. Expression spreads in the hypoblast towards the animal pole and converges dorsally. At the tail bud stage (9.5 hpf), transcripts are seen in adaxial cells flanking the future notochord and in the presomitic mesoderm (PSM). During early somitogenesis, expression also extends into the future head, in two stripes continuous with the adaxial cells. Expression continues around the developing eye, presomitic mesoderm (PSM), trunk adaxial cells and somites. In late somatogenesis, expression in the presumptive pronephric primodia lateral to the second and third somite. In the early pharyngula stage, expressed in the perioptic mesoderm. Expression continues in the PSM and adaxial cells in the tail
+Expressed in the somites at 8.5 dpc onwards
+Highly expressed in conidia, decreases during germination, and increases again in the mycelium
+No expression is seen in early embryogenesis, whereas high expression occurs in late embryos. During larval development, expression decreases to undetectable levels in late larvae, resumes at the early pupal stage and gradually increases in late pupae and early adult flies. High levels of expression coincide with major stages of neurogenesis
+Expressed both maternally and zygotically, with expression peaking at the neurula stage
+Present throughout embryonic, larval and pupal development and in female adults. Present at low levels in adult males (at protein level)
+Expressed in somatic cells, but not in germ cells, after the 30 cell stage
+Highly expressed during early stages of petal, stamen, carpel and ovule development, and expression decreases at the later stages of organ development
+Expressed from the L1 stage of larval development to adulthood
+Expressed in seedlings, from 6 to 21 days after seed imbibition
+Expressed throughout development with peaks of transcription during early embryogenesis, in pupae, and in adult males
+Expressed in female gametocytes and all downstream mosquito stages including the sporozoites inside the oocyst and the salivary gland, but not in asexual blood stages
+In the developing brain, expressed at relatively high levels from 10 dpc stages to young adulthood (P25) with peak levels from 14 dpc to P8. Levels of SOCS2 increase dramatically between 10 dpc and 12 dpc. At 12 dpc, high expression found in the olfactory epithelium with moderate expression in the neuroepithelium of the neocortex, presumptive striatum, hippocampus and septum. Low expression in the retina. At 14 dpc, in the cortical wall, levels increase in the cortical plate and decrease in the intermediate zone. High expression also in the hippocampus, fimbria, thalamic neuroepithelium and innermost layer of the retina. At P8, high expression in the neurons of the hippocampus. Lower levels found in the dentate gyrus. Levels of expression decrease between P8 and P15 and remain constant until P25. In adulthood, levels decrease. In the peripheral nervous system, expression found at low levels at 14 dpc in a subpopulation of neurons in the dorsal root ganglion
+Levels of p24 mRNA increase rapidly during early development and then drop sharply after aggregation
+Expressed in both the central and peripheral nervous system in developing mice
+More abundant early in development. At 13 dpc, highly expressed in the developing nervous system. Isoform y(+4)z(0), containing the 'y' insert but no 'z' insert, is the most prevelant at this stage with pronounced expression in developing spinal and sympathetic ganglia. Isoforms with no 'y' insert (y0) localized to peripheral tissue. At 15 dpc, y(+4) isoform continues to be highly expressed in neural tissue predominantly in the spinal column and developing brain. The y(0) isoform is weakly expressed in capillaries and meninges and the y(0)(z0) in non-neural tissues, predominantly in epithelial cells lining the developing lung bronchioles and kidney tubules. Isoforms Z(+8) and z(+19) are highly expressed in ventral motor columns and facial nerve with weaker expression throughout spinal cord tissue. At later stages of development, isoform y(4)z(0) is the most prominent form in developing cortex, corpus striatum, hippocampus and cerebellum. Isoform y(0)z(0) expression is still detected in brain capillaries at stage P1. The z(+19) isoform is most highly expressed from 15 dpc to 18 dpc and declines slightly to P1. Isoforms y(1)4z(0) and y(+4)z(+8) are still expressed in adulthood, the former scattered throughout the spinal cord gray matter and, the latter, in motor neurons of the ventral spinal cord
+Up-regulated between days 3 and 5 after germination and during senescence
+In adults expression is restricted to the gonads
+Abundantly expressed in the developing brain, in subventricular and ventricular zones of the cerebrum, where neural stem cells and neural precursor cells primarily exist. Expression levels gradually increase during brain development, between 14.5 dpc and P49
+Abundant in oocytes and present throughout cleavage and gastrula stage. Not readily detected at a stage when somitogenesis is nearly complete in 24 hours embryos. Steady state level decreases in a continuous fashion with developmental age
+Expressed in late pachytene
+Expressed and/or deposited to centromeres during G2 phase
+Expressed both maternally and zygotically. Zygotic expression begins at the onset of gastrulation (stage 10), and steadily increases until tadpole stage (stage 30)
+Expression increases from 10 dpc to 12 dpc and gradually decreases after 15 dpc (at protein level)
+In the developing brain, expressed as early as 10-13 dpc. Expression level peaks at 18 dpc and gradually decreases afterwards
+Ubiquitously expressed with strong signals in the primitive streak and in extraembryonic tissues at 7.5 dpc (PubMed:27061115). During further development, expression is strongest in the neuronal fold at 8.5 dpc (PubMed:27061115)
+Expressed in pachytene spermatocytes and early spermatids in the developing and adult testes and in oocytes in all stages of oogenesis in the ovary. Also expressed in preimplantive embryos
+Expressed in the embryo at the heart and torpedo stages. Weakly expressed throughout the vegetative shoot apex. Highly expressed in organogenic regions of floral apices
+Could be expressed in the forespore during sporulation
+Expressed at significantly higher levels during post-breeding. Not expressed in pituitary
+All stages
+Expression at early and late larval stages is 1:20 of unc-54 (mhc b), however later at L1 and L4 expression is more equal at 1:1.7 and 1:3.1 respectively
+Developmental regulation only occurs in the brain of mid-metamorphosic to post-metamorphosic tadpoles and adults, where an increase of several fold has been observed
+In the inner ear, it is first detectable at embryonic day 11.5 (11.5 dpc), broadly in the dorsolateral region of the otocyst, which gives rise to the vestibular organ. At 12.5 dpc, it becomes restricted to the presumptive sensory region, mainly to the BMP4-positive presumptive cristae, and expression becomes reduced at later stages
+Expressed in fetal neural stem progenitor cells in the brain (at protein levels)
+During male germ cell differentiation, expression of the beta isoform begins in the later stages of meiotic prophase and ends in the round spermatid stage
+First detected at stage 10.5 and peaks at mid-gastrula (stage 11.5)
+Expression is first apparent in bean-stage embryos, peaks in late embryogenesis, reduces in L1 larvae and is negligible in later larval stages and adults
+Levels accumulate after the removal of the food source and increase with the onset of development (accumulation at 1-3 hours) peaking at 5-7 hours of development and declining abruptly. Not expressed by mitotically dividing cells. Not measurable during vegetative growth on bacteria
+Expressed from the blastocyst stage
+In embryonic development of vascular endothelium, it shows a dynamic expression pattern within vessels, with expression starting in the larger axial vessels and intersomitic vessels at earlier ages, and changing to intersomitic vessel and capillary expression at later stages. At 9.0 dpc, is expressed in the central vessels, the dorsal aorta, and intersomitic vessels. At 9.5 dpc, is highly expressed in intersomitic vessels with little expression remaining in dorsal aortae. By 10.0 dpc, is detected in capillary vessels, the capillary plexus of the limb buds, and throughout the endothelium as microvessels sprout from the dorsal aortae. No expression was detected in the neural tube at 9.0 dpc and 9.5 dpc. However, it is detected within the capillaries sprouting into the neural tube, as well as in the adjacent perineural capillary plexus at 10.0 dpc. At 11.5 dpc, it is expressed in the endocardial layer of the cushions and delamination zones. By 17 dpc, it is detected in both the endothelial and interstitial cells of the developing aortic valve and endothelial cells of the proximal aorta. At 5 weeks after birth, it is localized to the endothelial layer of the ascending aorta and persists throughout postnatal development (PubMed:30455415)
+Its expression peaks in the oocyte and unfertilized egg, begins to decrease gradually after fertilization, and disappears during the gastrulation stage
+Cortical distribution begins at the late 1-cell stage, is more pronounced at the 2- and 4-cell stages and is reduced at late stages of embryonic development
+Expressed in neural cells at 10.5-11.5 dpc. At 10.5 to 16.5 dpc, in the developing spinal cord, specifically expressed in proliferating neural progenitors of the ventricular zone. In the developing forebrain and cerebellar primordium, expression is restricted to proliferating neuroepithelial progenitors and cerebellar granule precursors
+In bacterially grown celles expressed at 2 hours and 12 hours of development. In axenically grown cells expressed at 2 hours and 8/9 hours of development
+Up-regulated in bone marrow-derived mesenchymal stem cells during differentiation into adipocytes compared to osteoblasts
+Expressed in the presumptive fore- and hindlimb. Continues to be expressed in the limb mesenchyme throughout forelimb and hindlimb bud outgrowth. Expressed in the developing heart and eye
+Both isoforms 1 and 2 transcripts are expressed in seedlings and both TFIIIA and TFIIIA-C are present at similar ratios in 10-day-old seedlings (at protein level). In correlation with the reorganization of 5S rDNA chromatin to a mature state, full-length isoform 1 protein TFIIIA with transcriptional activity accumulates and permits de novo transcription of 5S rRNA. Isoforms 1 and 2 transcripts accumulate in various tissues of the reproductive phase, including flowers and siliques, but only isoform 2 is present in mature seeds. In flowers, both TFIIIA and TFIIIA-C are present at similar ratios (at protein level). Very low amounts of TFIIIA are found in extracts from fresh siliques compared to TFIIIA-C. The amount of full-length TFIIIA protein progressively increases from fresh siliques to seeds concomitant with lower proportions of the shorter TFIIIA-C protein (at protein level) thus leading to 5S rRNA accumulation in the seed
+Expressed in neural structures at 10 dpc. At 13 dpc and 15 dpc, highly expressed in neural tube, somites, heart and dispersed cells in tongue and face. At P5, widely expressed through the central nervous system in post-mitotic post-migratory zones. Brain expression decreases rapidly from P5 to P21 (at protein level)
+Expressed only during sporulation
+Induced at the transition to stationary phase
+Expressed exclusively in the endosperm of developing seeds, 25 to 30 days after flowering. Not expressed in the embryo or seed coat
+Present only during S and G2 phases of the cell cycle. Peaks at the G2/M phase of the cell cycle and drops rapidly at mitotic exit in an APC/C-dependent manner (at protein level)
+From the latter half of the larval final-instar, through the first two days of pupal development
+Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus. In dividing cells expression increases during S and G2 phases, peaks at mitosis and subsequently drops as cells enter G1 phase
+Expressed at low levels at the L1 to L3 larval stages, but begins to accumulate at the L4 stage and reaches its highest expression level at the gravid adult stage
+Elevated levels are observed during embryogenesis, liver regeneration, and adipocyte differentiation
+During floral transition, expressed very early at the flanks of the inflorescence meristem in the anlagens upon the transition to flowering Subsequently, expression levels increase in the first and second stages of the floral meristem and at stage 3, expression is restricted to the L1 and L2 layers. Later on, expressed in the gynoecium and stamen primordia at stage 6
+Highest levels in midgestational stages, 9.5 dpc to 15.5 dpc
+Abundant during nodule development
+Expressed maternally: detected as early as 0 hour post-fertilization (hpf), before zygotic expression transcripts starts
+At 12.5 dpc it is detected in dorsal root ganglia, AER, and surface ectoderm. At 14.5 dpc, found as well in cranial ganglia, thymus and olfactory epithelia. At 16.5 dpc, found as well in salivary gland, tooth buds and hair follicles
+In young seedlings, first observed in hydathodes and borders of new emerging cotyledons and in leaf primordia (PubMed:31862580). Accumulates in expanding leaves (PubMed:31862580)
+Expressed throughout growth and development with a strong increase in early and late development
+Expression is high in both fetal and newborn testis but minimal in testis of 7-day-old animals. Not detected in testis of 21-day-old or adult
+Expressed in gut after birth
+Expressed in the mother cell compartment from T2 of sporulation
+Expressed in tachyzoites (at protein level) (PubMed:17547703, PubMed:21616070, PubMed:32051238). Expressed in bradyzoites at higher levels (at protein level) (PubMed:32051238)
+Expressed both maternally and zygotically. In the embryo, expressed in the posterior hindbrain and anterior spinal cord at the 5-somite stage, with expression increasing through to the 15-somite stage. At the 15-somite stage, also expressed in the tail bud region. At the 18-somite stage, also found in the third neural crest stream
+Expressed from day 8 dpc along the epithelium of the differentiating neural tube. Expression persists along the dorsal axis until 12.5 dpc, but becomes progressively restricted to the more caudal part of the neural tube with much stronger intensity in the caudal neuropore. Also observed in the endoderm of the primitive gut between 8.5 and 11.5 dpc, at 10.5 dpc, in the endocardium and pericardium of the developing heart, and in both the endothelium and blood cells clustered at the ventral part of the dorsal aorta. Later in development (12.5 dpc), expressed in the endocardium and the interventricular septum of the heart
+Expressed in embryo at 6 dpc, onward
+Expressed during the middle and late stages of seed development
+Ubiquitously expressed throughout early development of the embryo
+Maternally and zygotically expressed. Zygotic expression increases after gastrula stage. Expressed in all three germ layers
+Detected in primitive ectoderm, mesoderm and ventral endoderm; down-regulated when organogenesis is completed
+Expressed primarily during the mid- and late stages of chlamydial growth, and can be detected in both reticulate bodies (RBs) and elementary bodies (EBs)
+First detected at 9.5 dpc in restricted domains of the developing diencephalon and along all the hindbrain and the spinal cord. At 10 dpc, found in the medioventral region of the developing spinal cord. At 12.5 dpc, expressed in restricted zones in the preoptic, postoptic and dorsoposterior regions. At later stages, in the intermedial region of the lateral horn, in the optic tract, the presumptive stria terminalis, the amygdaloid complex of the lateral horn in the spinal cord
+Expressed in the larva but not in the embryo
+Expression initiates prior to the onset of dentin mineralization and continues throughout the secretory stage of amelogenesis
+Displays strong neural pattern at 8.5 dpc to 12.5 dpc. Not expressed in the heart
+Expressed in hyp8-11 tail tip cells during the L4 larval stage
+Expression was detected in brain at 14 dpc and 18 dpc. At P5 expression in cerebellum is detected in both the dividing neuroblasts and post-mitotic neurons of the external granular layer as well as in the developing granule neurons of the internal granular layer while the expression in Purkinje cells was lower. At P10 the expression in external and internal granular layers remained strong while at the same time the Purkinje cells also acquired significant level of expression
+Expressed throughout development, high during embryonic and adult stages. Isoform T2 is predominantly expressed during larval and adult stages
+In young seedlings, expressed in the shoot apical meristem (SAM) and in root tips (PubMed:22897245). In inflorescence, specifically observed in mature pollen (PubMed:22897245). Present from the early bicellular pollen stage to the mature pollen stage; levels in vegetative cells increase during the development of pollen (PubMed:22897245). Detected in the germinating pollen tubes (PubMed:22897245)
+Expressed in the developing epidermis and intestinal epithelium. First detected in the epidermis at stage 13.5-14.5 dpc with higher levels in the head and thorax regions. At 15.5 dpc, expression is found in both the epithelium and, to a lesser extent in the underlying mesenchyme. At day 16.5 dpc, high expression in the basal cells. Later expression is found in the developing hair follicles, around the dermal papillae. In the developing intestinal epithelium, expression first observed around 14.5 dpc. Levels continue to increase at least until 19.5 dpc, with highest levels in the intervillus epithelium and in the bottom half of the villi. In the nervous system, first expressed at 9.5 dpc, in the forebrain. At 10.5 dpc, expressed broadly in the brain, and at lower levels in the upper regions of the spinal cord. By 11.5 dpc, E2F2 expression is found throughout the central nervous system and levels peak at 12.5-15.5 dpc. In the developing spinal cord, E2F2 expression found only in the dorsal region. In the developing retina, highest expression found in the 14.5-18.5 dpc embryonic retinoblastic cell layer. In other developing tissues, E2F2 is found highest in thymus and liver, with lower expression in lung, heart, kidney and skeletal muscle. Also found in choroid plexus and chondrocytes
+Decreases with development
+Expressed in embryonic brain, liver and spleen (at protein level). First detected at 7.5 dpc in the node. Expressed in the cephalic mesenchyme and tail bud at 8.5 dpc, and in the branchial arch and forelimb bud at 9.5 dpc. In the central nervous system, expression begins and persists in the regions where the neurons differentiate. Expression is also strong in the peripheral nervous system, including sensory cranial ganglia, dorsal root ganglia, and autonomic ganglia, and in the sensory organs, such as the inner nuclear layer of the neural retina, saccule and cochlea of the inner ear, and nasal epithelium. Outside the nervous system, expression is detected in the cartilage, tongue, lung bud, stomach, and gonad from 12.5 dpc to 14.5 dpc, and in the tooth bud, bronchial epithelium, and kidney at 17.5 dpc
+In the developing cerebellum, increasing levels after birth. The majority of this increase occurs around postnataL day 9 reaching a peak at postnatal day 15-18 which is maintained in adults
+In embryos, not detected until 3 days before hatching when it is significantly expressed in the right but not in the left parietal giant interneurons. In juveniles under a month old, expression is higher in the right parietal giant interneurons compared to the left
+Found at all stages
+Levels increase between embryonic day 21 (21 dpc) and postnatal day 1 (P1) and then gradually increase up to P15. There is a slight increase between P15 and adulthood
+Not detected at 9.5 dpc and 10.5 dpc. Specifically expressed in male and not female gonads during their differentiation, from 12.5 dpc to 14.5 dpc
+Expressed during dehydration, dormancy, air dispersion, hydrated preactivated and germination stages. In hydrated pollen grains, expressed in discarded exine, the exudates, and the orbicules. Expressed in developing lamellate structures of the microspore cell cytoplasm
+Induced during post-germinative growth. Detected in imbibed seeds
+Expressed in gut cells of the pretzel stage embryo and throughout the larval stages (PubMed:20687916). Expressed in adult males and hermaphrodites, in the pharynx, body hypodermis, and intestine (PubMed:20687916). Expressed in support cells of neuronal sensilla, such as amphid and phasmid socket cells in hermaphrodites, and cell bodies and processes of all sensory rays in males (PubMed:20687916)
+First expressed in the gonadal leader cells, the distal tip cells (DTCs) in hermaphrodites and linker cells in males, during the early larval L2 stage (PubMed:17588558). Expression in the linker cells in males continues until larval stage L4 (PubMed:17588558). Expression in DTCs in hermaphrodites continues until adulthood (PubMed:17588558)
+First detected in the vegetal hemisphere at the 32-cell stage. Expression continues in endothelial lineage until 110-cell stage when it declines here and becomes evident in muscle lineage cells. Expression increases throughout gastrulation and neurulation in differentiating muscle cells until late tailbud stage. Expression also detected in the tailbud tip from mid-gastrulation to tail elongation
+Expressed in all larval stages
+In the developing embryo, it is confined to the gut and caudal hindbrain. In caudal hindbrain, it is specifically expressed in a subpopulation of differentiating V2 neurons. Not detected prior to 12.5 dpc and is not found in motor nuclei. At 12.5 dpc, it is expressed in the ventral medial aspect of the medullary reticular formation (MDR). At 16.5 dpc, expression is confined to the gigantocellular nucleus, a nucleus that is part of the MDR. In addition to the CNS, it is also expressed in the developing gut, in duodenal and glandular stomach endoderm and, at the end of gestation becomes restricted to the base of the gastric units in the glandular stomach. Expressed at very low level in the pancreatic epithelium. Expressed in the pancreas at 15.5 dpc
+Expressed at all larval stages
+Expressed in seam cells in embryos from around 260 minutes post fertilization and in all subsequent developmental stages (PubMed:16236764, PubMed:16226243). Also expressed at the comma stage, at about 400 min, in the body wall muscle cells (PubMed:16226243). Expressed in males, in the descendant cells of the V5, V6, and T lineages, which include all the A-type neuron, the B-type neuron, and the structural cells of the male-specific sense organs, known as rays, from the mid-L3 larval stage to L4 stage (PubMed:15385167). Expressed in dopaminergic neurons at larval stage L4 (PubMed:31083672)
+Increases during germination
+Expressed highly in embryos (at protein level) (PubMed:16701565, PubMed:17369820). Expression decreases in larvae and increases again in adults (at protein level) (PubMed:16701565, PubMed:17369820). At the L4 larval stage, expressed in the proximal gonad, predominantly at the pachytene stage and in spermatocytes (PubMed:19773360). Not expressed in sperm (PubMed:19773360)
+Expressed in the developing central nervous system and in sensory neurons (PubMed:25009257). Expression is detected at 4.5 hours post-fertilization (hpf) (PubMed:25463516). During development, strongly expressed in the forebrain, midbrain and hindbrain during brain development (PubMed:25463516). Compared to clstn3, expression appears broader in the telencephalon and extends more dorsally in the midbrain (PubMed:25463516). Broadly expressed in the spinal cord (PubMed:25463516)
+Expressed in ookinetes (at protein level)
+Expressed at higher levels in sink as compared with source leaves
+Not expressed in germinating seeds. Expressed during cell or organ differentiation
+No change during brain development
+Present during the earliest stages of limb maturation and is later found in regions where the joints develop
+Expressed during development; with a peak at 12 hours
+Maximum mRNA abundance around mid-phase of grain development
+Expressed at the blastocyst stage and the embryonic days 8-17, as well as in undifferentiated and differentiated embryonic stem cells. Expressed in the arcuate nucleus of both male and female animals. Levels of expression are highest on postnatal days 10 and 12, begin to decline on day 15, and reaches a nadir by days 18 to 22, at which time expression is 10 to 20% of the levels detected at 10 days. The timing of the decline in protein expression correlated with the ages at which arcuate KISS1 and TAC2 have been shown to increase, heralding the onset of puberty
+Strongly up-regulated during osteoclastogenesis. Expressed in calvariae and developing teeth as early as 16.5 dpc (at protein level)
+Highly expressed in the embryonic and larval nervous system
+In the developing embryo, first detected at the rostral tip of the primitive streak, Hensen's node, at the late streak stage. At the late headfold stage, expression demarcates the layer of the node from which definitive endoderm and midline mesoderm arises. At 6-8 somite stage observed in the definitive endoderm. Strong expression is detected in the caudal intestinal portal. At 12-15 somite stage is still present in the hindgut, but transient expression is also seen in tissues of neural and mesodermal origins. At 13 dpc present around all sites of cartilage formation, such as cervical vertebral bodies, ribs and Merckel's cartilage. Additionally, expressed in the derivatives of the pleuroperitoneal membrane, the diaphragm and the pericardium, as well as the mesenchyme of the developing lung. Expressed in both the mesonephros and metanephros
+Mostly abundant in mature female strobili, with lower expression in developing female strobili and in mature male strobili
+Expressed from 8 hours post-fertilization (hpf). Expressed in the midbrain and the optic primordia from 14 hpf and around the eyes, the branchial pouches and the neural tube at 24 hpf. By 48 hpf, expression in the midbrain, branchial pouches and the neural tube was reduced to a very low level
+It appears in the roots within 30 min of induction, maximum levels are reached by 6 hours, and remains constant for 2 days. In leaves it is seen 9 hours after induction, and reaches maximum levels after 24 hours
+Expression begins in the first week of postnatal life
+Detected from at stage 7, where it is expressed in the early germ band. By stage 11, when the germ band is fully extended, it is expressed strongly in the ventral neuroectoderm, which represents the progenitor of the CNS. At this time, a small region of particularly strong expression is visible at the tip of the extended germ band marking the proctodeum (the primordial hindgut) and expression is also visible in the anterior midgut and the foregut primordial region known as the stomodeum. Expression then persists in both the emerging gut and nervous system during the next three developmental stages (12-14). Strong expression in the primordial midgut is rapidly down-regulated prior to stage 15, by when the presumptive midgut has closed both ventrally and dorsally and is largely established. However, expression persists in the hindgut as it continues to develop by projecting towards the antero-dorsal region of the embryo and is also evident in differentiating components of the foregut, which might include the stomatogastric nervous system. Interestingly, it is expressed strongly throughout the developing CNS and the intensity of this staining is maintained through stage 16 during major periods of developmental reorganization, while expression in regions of the gut is rapidly down-regulated. Expression continues in the CNS late into stage 17, but is also clearly reduced by the end of stage 17 immediately prior to hatching. Expressed during all subsequent developmental stages from first instar larvae through to adulthood
+Expressed during seed maturation. Expressed in maturing seeds about 2 weeks after flowering. Expression continues steadily thereafter until it decreases in the seed-drying stage, reaching undetectable levels in mature seeds
+During gestation (7dpc to 15 dpc) its expression is up-regulated. In 15 dpc embryo is expressed in muscle cells of heterogeneous origin, including those from tongue, trunk, and tail. In newborn mice localized to limb striated muscle cells. Expressed in myoblasts undergoing myogenic differentiation during proliferation and differentiation phases (PubMed:12711387). Expressed in spinal chord motor neurons at 10.5 dpc. Detected in the plexus region of the developing limb bud at 10.5 dpc and 11.5 dpc (PubMed:20437528)
+Expressed in the embryonic, pupal and adult stages, with little expression during the larval stages
+Expressed throughout development with highest expression seen in adults
+Expressed in the developing sciatic nerve, with increasing expression from newborn to postnatal day 20, and decreasing expression at postnatal day 60 (P60) (at protein level) (PubMed:20237282). Expressed in the developing neural tube, optic vesicle, branchial arches and kidney at 10.5 dpc (PubMed:17920587). Expressed in the ventricular layers of the developing neural tube along the entire cranial-caudal length, including the anterior forebrain and the posterior spinal cord at 11.5 dpc (PubMed:17920587). Highly expressed in cortical progenitor cells at 12 dpc, expression decreases during neurogenesis but weak expression is still present at birth (PubMed:20399730). Expressed in the developing brain at 15.5 dpc in the upper rhombic lip, ventricular zone, and external granule layer (EGL) (at protein level) (PubMed:26657772). At birth expressed in the ventricular apical lining cells, proliferating external granule layer and Purkinje cell layer (PCL), with expression remaining abundant in the EGL and weakly evident in the PCL at P6 (at protein level) (PubMed:26657772). Expressed at P8 in the EGL, cerebellar granule neuron precursors, Bergmann glia, Pcna-positive progenitor cells in the white matter, and weakly in Pax6-positive postmitotic granule neurons (at protein level) (PubMed:26657772). Expressed weakly throughout the retina between 12.5 dpc and 14.5 dpc, becoming enriched in progenitors at the outer neuroblastic layer at 14.5 dpc (PubMed:22398208). Expressed in the retinal layer of the optic vesicle, and weakly expressed in the retinal pigment epithelium at 12.5 dpc (PubMed:17920587). Localized to the apical edge of the retina between 12.5 and 16.5 dpc (PubMed:22398208). Expressed in the internal endodermal layer and in the developing saccules of the lung at 11.5 dpc (PubMed:17920587). Expressed at the outer limiting membrane of the retina at 18.5 dpc and 3 months of age (PubMed:23001562)
+Expressed throughout the embryonic developmental stages from 5 dpc to 19 dpc (at protein level)
+Expression increases sharply after germination and reamins high in the mature plant
+Expressed in embryos and larvae. Not expressed in adults
+Produced during sporulation. The expression decreases considerably with cell lysis
+The maternal protein is detected up to the blastula stage but declines by the early glastrula. Zygotic expression starts at around early gastrula; the level of expression reached at stage 15 persists during neurula and tailbud stages, and is further increased during the tadpole stages
+At 24 h post-fertilization (hpf), it is mainly expressed in the central nervous system and Rohon-Beard sensory neurons. It is detected in the brain and motor neurons of the spinal cord at 48 hpf
+Fades out in old roots and leaves
+Expressed within the early somite and then becomes restricted to the external cell layer (ECL) and consequently to appendicular muscle populations
+Expression in head mesodermal cells detected from L3 stage to adult stages, and in vulval muscles from L4 stage to adult stages
+Present at very low level in one-cell embryos, suggesting the presence of maternally deposited transcripts. Increases upon the onset of zygotic transcription (around the 1000-cell stage), eventually peaking at 72 hpf
+Highly expressed during early stages leaf development, and expression decreases at the later stages of leaf development
+Expressed soon after the start of myoblast differentiation and in skeletal muscle throughout life from at least 14 weeks gestation (at protein level)
+Expression levels oscillate moderately through the cell cycle
+Detected in primitive endoderm at 4.5 dpc, and on the apical surface of the visceral endoderm from 5.5 dpc to 8.5 dpc. Expressed in mesonephric tubules at 11.5-12.5 dpc and in the metanephric kidney beginning at 14.5 dpc. Expressed in the intestine from 16.5 dpc
+Expression increases in fruit pulp at early stages of fruit ripening and then decreases in late stages (PubMed:9342866). Expression increases in fruit peel and pulp during ripening (at protein level) (PubMed:20467747)
+Expressed during all larval stages and in adult animals (at protein level)
+Expressed in early and late larvae, in pupae and, to a lesser extent, in adults
+In embryo expressed to the surface chondrocytes of developing joint cartilage and to the connective tissue of reproductive organs
+Expressed during the S phase of the cell cycle
+Appears during seed development and remains in mature seeds
+Expressed during the embryonic brain development from 11.5 dpc, onwards (PubMed:24720729). Expressed in the upper layers of the cortex at 11.5 dpc (PubMed:24720729). Expressed in the intermediate zone to the cortical plate of the cortex at 18.5 dpc (PubMed:24720729). Expressed in neurons (at protein level) (PubMed:24720729)
+Expressed in brain, lung, skeletal muscle, heart and intestine in 80-day old embryo
+Expressed in developing guard cells but not in mature ones (PubMed:20943851). During male gametogenesis, observed in microspores and pollen (PubMed:20943851)
+Initially expressed at 8.5 dpc in the developing rhombencephalon. At 11.5 dpc expression in the CNS rapidly decreases and in newborn and adult expression is not detectable in the brain with the exceptions of Purkinje neurons and the choroid plexi
+In brains, expressed at low levels after birth, expression highly increases at 2 weeks after birth to decrease and be maintained at 4 weeks after birth until, at least, 18 months (PubMed:21994399). Expression increases in differentiated adipocytes (PubMed:28698261)
+Expressed predominantly in neonatal tissues, at lower levels in adult
+Expressed during embryogenesis with very low levels found in the larva and adult
+Expressed throughout embryogenesis, from the 1 cell stage to 48 hours post fertilization (hpf), with the highest levels of expression at the 1 cell stage (PubMed:30903017). In larvae 7 days post fertilization (dpf), strongly expressed specifically in nerve cells in the preoptic area of the anterior hypothalamus (PubMed:30903017). Not detected in the dorsal habenula (dHb) (PubMed:30903017)
+Expressed in embryo (at protein level) (PubMed:9732281). Expressed in ovaries; more specifically in the germarium and throughout egg chamber development both in germ line and nurse cells (at protein level) (PubMed:9732281, PubMed:17410542, PubMed:17277377). Expressed in spermatocytes (at protein level) (PubMed:9732281). In embryos, detected during germ-band elongation and in the developing mesoderm (PubMed:10511559). At stage 11, mostly prominent in the central nervous system and gut (PubMed:10511559). By stage 14, detected in the brain and dorsal vessel (PubMed:10511559). At the end of embryogenesis restricted to lymph glands (hematopoietic organ), gonadal germline and specific neurons in the brain (PubMed:10511559). In larvae, detected in the imaginal disks, certain regions of the brain and all tissues containing dividing cells (PubMed:10511559). In larval, detected in testes and in all germline cells up through the meiotic stages (PubMed:10511559). In adult, detected in testes, ovaries in germanium region 2 and throughout later stage of oogenesis (PubMed:10511559)
+Expressed throughout the epidermis in larvae with the exception of the bristle cells. Only found in the flexible intersegmental cuticle during endocuticular deposition in the pharate pupae. Restricted to epidermal cells at the muscle attachment sites in the adult
+Transiently expressed in DD GABAergic motor neurons in embryos and during larval stage L1, with expression decreasing as development proceeds (PubMed:26387713, PubMed:26083757). Expressed strongly in VD GABAergic motor neurons from the end of larval stage L1 onwards and in particular along the ventral nerve cord (PubMed:26387713, PubMed:26083757). Specifically expressed in DD GABAergic motor neurons in the dorsal and ventral nerve cords at larval stages L1 and L4 (PubMed:26387713)
+In 3-week postnatal brain, prominent in the cortex and in the hippocampus. In the hippocampal formation, detectable in the CA1-CA3 pyramidal cells and in the granule cell layer of the dentate gyrus. In the cerebral cortex, expressed in all layers (I-VI) (at protein level). In 10 week old animals, tends to segregate in CA3 regions
+Expression detectable at 9.5 dpc and progressively increases from 11.5 dpc onwards (at protein level)
+Levels increase after birth and remain high at postnatal days 14 and 21
+Sporulation
+Selectively expressed in stalk cells. If an aggregate enters culmination immediately it is expressed in the bottom half of the stalk and in the basal disk but if a migratory slug is formed it is also expressed in the top of the stalk and in a disk of cells that surmounts the spore head
+In brain, expressed from embryo to adult with a constant increase during postnatal development in the cerebral cortex (at protein level) (PubMed:31600191). Expressed at all stages of embryonic development, including 7 dpc, 11 dpc, 15 dpc and 17 dpc (PubMed:12137943). Higher level of expression is seen at later stages of embryonic development (PubMed:12137943). In 9.5 dpc embryos, expression is diffusely distributed in the regions of the brain, optic vesicles, otic vesicles, cervical and upper thoracic segments of the spinal cord (PubMed:12137943). The expression is more intense in the dorsal portions of the central nervous system (CNS) (PubMed:12137943). In the brain, expression is localized in prosencephalon, mesencephalon and rhombencephalon (PubMed:12137943). In 10.5 embryos, expression area is more restricted, but still within the CNS and the sense organs. The spinal cord expression disappears (PubMed:12137943)
+Highly express in primitive erythroblast that fill yorlk sac blood islands at early somite pair stages, and in fetal liver at 12.5 dpc
+In roots, observed in all cells of the root tip, inculding both meristem and elongation zones, but restricted to vascular tissues of the maturation zone (PubMed:29284002, PubMed:29283991). Also observed in shoot apical meristems, lateral root primordia and the vascular system. Under dark conditions, present in the concave side of the apical hook (PubMed:29283991)
+Probably maternally supplied, the zygotic expression is detected early during development at the 512-cell stage but decreases after 7.5 hpf
+Expressed throughout development with highest levels being observed in nonfeeding stages, i.e. during embryonic and pupal development
+Isoform 3 is expressed as early as embryonic day 10
+Developmentally regulated and preferentially expressed starting at the mound stage in response to cAMP. Expression seems to require the transcription factor gbfA
+During flower development, expressed in the transmitting tract of the septum from stage 12 to stage 15
+First observed at the tip of rosette leaves (PubMed:24173806). Present in developing flowers (PubMed:29259105). Accumulates in inflorescence apices and broadly in floral meristems and flowers (PubMed:25256344). Expressed throughout young ovules (PubMed:25256344)
+Expressed during vegetative stage. Expression decreases during development and disappears from 8 hours
+In the postnatal testis, reaches a peak of expression at postnatal days 26-28 (at protein level) (PubMed:35700329). Expression is undetectable until postnatal day 21 corresponding to the 142 stage of round spermatids (PubMed:35700329)
+In the eye imaginal disk, first expressed at the onset of the third instar and continues throughout this stage. Expression in the optic lobe primordium begins at stage 5 and disappears when invagination is completed (stage 12). Further expression is noted in optic lobe ganglia in late third instar
+Sporulation specific. Expression starts 1 to 2 hours after the initiation of sporulation. Found only in mother cells
+In nonelongating internodes, highly expressed in interfascicular fibers and xylem cells but not in parenchymatous pith cells. In elongating internodes, predominantly expressed in interfascicular fibers. Accumulates in the developing secondary xylem of roots
+Initially expressed at 6.5 dpc, which coincides with gastrulation of the embryo. High level of expression in developing limb buds at 10.5 to 12.5 dpc
+Ubiquitous through the epiblast. Expression is detected in mesoderm and most strongly in ectoderm, but not in endoderm. Highly expressed in the region of the node, a depression at the surface of the embryo proposed to have a role in left-right axis patterning. At 8.5 dpc, it is widely expressed except in the heart. Stronger expression is observed in the anterior midline, the forebrain and the somites. Strong expression remains in the forebrain at 9.5 dpc and 10.5 dpc and extends to all regions of the neural tube. At those stages, high expression is also found in the branchial arches and in the limb buds. Embryo section at 9.5 dpc also shows expression throughout the neural tube and the mesoderm, but not in the surface ectoderm. The strongest expression is observed on the luminal edge of the neural tube and in the ventral foregut
+First observed in carpels and seeds at early stages of development, mostly in embryo and, at lower extent, in the endosperm. Accumulates and peaks at maturation. Fade out during late seed development steps, restricted to the inner layer of the seed coat, and, at very low levels, in the mature embryo and the remaining endosperm. Also present in the lignified inner subepidermal layer of the valves. In the anthers, restricted to the connective tissue at pre- and post-dehiscence stages and detected in the vascular tissue of the stamen filament
+Expressed in liver during embryogenesis. Levels higher in liver than in brain up to 15 weeks after hatching. In the brain, first detected at 11 weeks after hatching and increasing levels from 15 weeks to maturity (25 weeks). Expression in the liver is much lower throughout these later stages of hatching
+First expression detected at 3.5 to 4 weeks
+Detected at 16 days post coitum (dpc) in both epithelial and mesenchymal components of the tooth organ (PubMed:26927967). Also detected at 16 dpc and 18 dpc in mandibular bone osteocytes (PubMed:26428891). Detected at 15 dpc in the bone collar (PubMed:26428891). Detected at 13 dpc in the cartilage matrix (PubMed:26428891). Detected at postnatal day 3 in odontoblasts and ameloblasts (PubMed:22042093). At postnatal day 5, expression is decreased in dental papilla cells, but increased in the predentin (PubMed:22042093). By postnatal day 9, is only detected in the predentin (PubMed:22042093). Detected at postnatal day 2 in osteoblasts, the calcified cartilage cores in primary metaphyseal bone and in osterocytes embedded in cortical bone matrix (PubMed:15221418). At postnatal day 84 expression is detected in the osteocytes of cortical and trabecular bone (PubMed:15221418)
+Highly expressed in the brain in the ventricular and subventricular zones, caudal and lateral ganglionic eminences and cerebellar primordium at 16-21 postconceptional week
+Expressed in skeletal muscle tissue during embryonic development and for 2 weeks after hatching; becomes undetectable 3 weeks after hatching (at protein level)
+Low constitutive expression in etiolated seedlings and immature yellow leaves. Higher expression in mature green leaves
+Expressed during osteoblast differentiation and bone development. Detected in embryonic bone formation in calvariae and tibiae. Very low expression in neonate bone tissues. Expressed in kidney and brain
+In the embryo, expression is high during early development but drops during later development
+Accumulates following maturation of flower buds
+Detected in cotyledons and roots at 1 day postimbibition, reaching a maximum at 4 days postimbibition. Hypocotyl levels are constant from 3 to 10 days postimbibition
+Mainly expressed in the neural tube and limb buds during early embryonic development. Also present in testis: at the onset of spermatogenesis, it is expressed in spermatogonia, pachytene, and diplotene spermatocytes. In Sertoli cells it is expressed in a stage-dependent manner, with high expression levels at stages II-VI and VII-VIII
+Expression is higher in fruiting bodies and spores than in primordia, and very low in mycelia (PubMed:31655558). In the fruiting body, present in the cap, gill, pileipellis but not in the stipe (PubMed:31655558)
+Found to be expressed in developing spermatocytes, but not in terminally differentiated spermatozoa
+High expression in embryos and adult tissues, lower expression in larval and pupal stages (PubMed:11677042). Expression levels decrease in an age-dependent manner, levels are 75% less on day 30 than on day 5 post eclosion (PubMed:23124252)
+Present in ooplasm of stage I, II, and III oocytes. Present in the vitelline envelope
+Expressed within 2 hours after induction and continued to accumulate over 24 hours
+First detected at 10.5 dpc. At 11.5 dpc, in the developing heart, expressed in the atrioventricular endocardial cushion and the outflow tract (at protein level). At 14.5 dpc, strong expression in the outflow tracts, including valves. In the developing skeleton, expressed at 12.5 dpc in the vertebral column and limbs. At 14.5 dpc, expressed in rudiments of tendons and ligaments along the vertebrae, as well as in mesenchymal cells surrounding precartilage condensations. Not detected in precartilage condensations, nor in chondrocytes, but strongly expressed in ossification centers. At 17.5 dpc, in the hind limb, significant expression persists in tendons and ligaments, but expression in the forming joints is reduced. At this stage, weakly detected in the thin layer of articular surfaces. Postnatally, in long bones, expressed by terminally differentiated hypertrophic chondrocytes that are committed to degeneration and eventually replaced by bone, as well as by osteoblasts at late differentiation stages and by mature osteocytes. In the developing brain, expressed in specific regions of the neuroepithelium in the forebrain and hindbrain adjacent to the forming choroid plexus. From 17.5 dpc till birth, expressed in neurogenic areas including ventricular zones (at protein level). At 12.5 and 14.5 dpc, expressed in Muellerian duct cells and in the surrounding mesenchyme in both male and female gonads. In the lung, detected in the mesenchymal cells. Expressed at 12.5 dpc in abdominal skin, both in epidermis and dermis. Also expressed in the epithelium of developing whiskers at 14.5 dpc. At later stages, localized in the basal layer of epidermis and in the invading epidermal cells that formed the whisker rudiments (at protein level). 9 days after birth, detected in the whisker outer root sheet (at protein level)
+Detected in whole embryo from 5 dpc with highest expression at 8, 11, 12, and 18 dpc. Expressed at 18 dpc in brain, a clear reduction occurs after birth followed by a transient increase around 2 weeks to 1 month. Hardly detected in adult brain
+Expressed in germinating seeds from 24 hours after imbibation, and reaches a maximum level at 72 hours. After 96 hours, it then decreases
+Expressed at the late stage of silique development
+Expressed both maternally and zygotically (PubMed:21553381). Ubiquitous expression until the early somitogenesis stage (PubMed:21553381). In later embryonic stages, detected in the otic vesicles, hatching gland cells, pectoral fin, posterior tectum and swim bladder (PubMed:21553381)
+Widely expressed throughout embryogenesis. At gastrula stage (st. 10.5), equal expression in ventral and dorsal marginal zones. At neurula stage (st. 18), highest expression levels in ectodermal cells
+Expressed at high levels in several developing projection systems: in neurons of the thalamus, subplate, and lower cortical laminae in the forebrain and in the pontine nucleus, cerebellar granule cells, and Purkinje cells in the hindbrain
+Expressed at higher level in S-phase than in quiescent cells
+Expressed weakly in ganglion cell layer (GCL) and inner neuroblastic layer (NBL) of the embryonic retina at 15.5 dpc. Expression increases progressively in the retina from new borns at postnatal day 2 (P2), P5, P15 to 8 week-old adult (at protein level)
+Expressed during embryogenesis. High level expression seen in fetal kidney and lung while a low level expression seen in the fetal brain
+Abundantly expressed from an early stage of the embryo throughout development. Ubiquitously expressed, especially in the musculoskeletal system, heart and neural tissues
+Detected following the activation of the zygotic genome in a few deep cells of the marginal region of the blastoderm. From the 5-12 somite stage, expression is observed in the dorsal telencephalon and in posterior and ventral parts of the eye field. By the 12-somite stage detected all along the dorsal neural tube from the level of the diencephalon to the caudal spinal cord and this expression persists until 24 hours of development. At the 15-somite stage expression is seen in the midline around the tail bud. Between 15 and 20 hours development dorsal as well as ventral expression is observed in recently formed somites while in more mature somites, detected only ventrally. By 24 hours development expression is limited to the ventral sclerotomal aspect of the caudal somites. Later in development detected in very restricted parts of the CNS
+Last instar larvae
+Expressed in differentiating myoblasts at a time of myotube formation
+Expressed in ameloblasts at the periphery of mandibular molars at P1 (PubMed:12657653). At P3 also expressed at the molar incisal region (PubMed:12657653). Expressed at the terminal of Tomes' processes of ameloblasts at the incisal region at P5 (PubMed:12657653)
+Expressed in embryos, larvae and adults (at protein level) (PubMed:12853134, PubMed:16684534). Expressed in the excretory cell, intestine and hypodermis throughout all developmental stages and in adults (at protein level) (PubMed:12853134, PubMed:16684534)
+Expressed at detectable levels 30 days after birth and increased greatly during the next 10 days
+Abundantly expressed in developing embryos, especially in mesenchymal condensations of limbs, vertebral perichondrium and mesenchymal cells of the intervertebral disks
+Embryo and adult
+Expressed in the primordial germ cells Z2 and Z3 in embryos and in proliferating germ cells in L2/L3 stage larvae (at protein level)
+Detectable in morula and blastocyst. First expressed in ectoplacental cone in embryos of 6.5 days and in extraembryonic visceral endoderm at 7.5 days. Expressed also in the allantois. Expression in the ectoplacental cone-derived secondary trophoblast giant cells and spongiotrophoblast is strong up to 11.5 days and then declines. In the embryo, high levels are initially expressed in blood vessels, perineural mesenchyme and somites at 8.5 days. Later on, intense expression is identified in the mesenchymal component of organs anlage (ie lung and liver) and different mesenchymal condensations (ie limb bud and branchial arches). At late gestation expression is widely distributed in interstitial connective tissue and smooth muscle cell-rich tissues
+Expressed in the dorsal somite derivatives of the chicken as well as in the dorsal subpopulation of trunk crest cells
+Expression starts at 12.5 dpc and is restricted to developing cartilage
+Present in both unfused and recently fused myotubes, but not thereafter
+Expressed during the asexual blood stage including at the ring stage and in trophozoites and schizonts (at protein level)
+Expressed in all life-cycle stages but at higher levels in the amastigote stage in the mammal and in stationary phase promastigote cultures which contain the infective metacyclic form of the parasite
+First detected 48 hours post-fertilization (hpf) in the ventral thalamus, ventral midbrain, ventral cerebellum, ventral hindbrain, dorsal thalamus, hypothalamus, telencephalon, along the tract of the anterior commissure. Weakly expressed in the dorsal midbrain and olfactory bulb. Expression increases by 96 hpf and is detected in the tectum and trunk
+Fetal kidney expresses isoforms 3, 4, 5, 6 and 7, and fetal liver expresses isoforms 3 and 4
+Increased expression throughout development from 9.5 dpc to 18.5 dpc in placenta and, from 12.5 dpc to 15.5 dpc in embryo. Barely detectable in adult brain and midbrains of 14.5 dpc, but abundant at 8.5 dpc
+Expressed at constant levels during growth and throughout development. Uniformly expressed throughout the prespore and the prestalk regions at the finger stage as well as during culmination
+Expression begins at 16 hpf and gradually increases up to 72 hpf
+Is moderately detected in planulae and a little more detected in primary polyps (9d), as well as in both adult females and males (at protein level) (PubMed:33060291). Transcripts are expressed early in the life cycle and their expression is maintained through the adult stage (PubMed:29739837)
+Isoform C: Barely detectable in adult body but is expressed in adult head and third instar larva. Isoform B: Detected in adult head, adult body, pupa, third instar larva, 0-4 hour embryo, 0-18 hour embryo and 17-19 hour embryo with lowest expression observed in adult body and 17-19 hour embryo
+Primarily expressed by the amastigote stage. Expressed 15 times more in amastigotes than in promastigotes
+Expressed in embryo at 7 dpc onwards. Expressed in rib, sternal cartilage, heart, kidney, leg muscles, intestine and limb at 7 dpc. Expressed in chondrocytes at 14.5 dpc. Expressed in cartilage at 14 dpc. Present in rib cartilage and choroid plexus epithelium at 16.5 dpc (at protein level)
+Expressed in the embryo at 4 days after pollination (DAP) in the ventral and basal part of the embryo, including the initial of the shoot apical meristem (SAM). At 5 DAP, expressed at the ventral side of the embryo, but the expression within SAM is down-regulated. At 7 DAP, expression is restricted to the boundaries between the embryonic organs, between the scutellum and the coleoptile, the coleoptile and the second leaf primordium, the shoot apical meristem and the first leaf primordium, the first leaf primordium and the coleoptile, the coleoptile and the epiblast and at the tip of the epiblast, but not in the leaf primordia
+In flowers, mostly present in sepals, stigmatic papillae, gynoecium (apical part) and filaments. Excluded from anthers (at protein level). In developing siliques, localized in the apical part and the abscission zone. In seedlings, expressed in cotyledons, hypocotyls, and root tip. Accumulates slowly in leaves as they mature, in the mesophyll and the cells that surround the vascular bundles
+At 9.5-10.5 dpc, expressed in the developing maxillary prominence and the lateral nasal process, as well as in the limbs and eye
+Not expressed during gastrulation, and shortly after gastrulation found in the cells of the ventral fore-brain rudiment, and hind-brain neural crest cells. Not expressed in the auditory vesicles, found in low levels in localized regions of the median fin fold, and is also expressed by the cells of the visceral arches and their primordia
+Expressed during the parasite blood stage, including in trophozoites, schizonts and free merozoites (at protein level)
+Abundant in embryos and adults
+Expressed in oocytes during meiosis I and II followed by proteasomal degradation at the 1-cell and 2-cell embryonic stages (at protein level)
+Detected in 7 dpc, 11 dpc, 15 dpc and 17 dpc embryo
+In seedlings, especially present in the vascular system. In flowers, observed in sepals, anthers of stamen, and pollen
+There is a marked increase after postnatal stages 18-20 (simultaneously to the appearance of haploid cell stages). Maximal expression is observed around 2 weeks postnatally, with the exception of brain and testis, where the expression is highest in earlier developmental stages
+Expressed in fetal liver and fetal brain
+Expressed in embryo, where it is also completely restricted to neuronal tissues, including brain, dorsal root ganglia and enteric nervous system. MRNA and protein expressions are not correlated during development
+Expressed in protodermal cells in young seedlings
+Expressed throughout development from the pre-bean embryonic stages to the adult stage
+Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases
+Expressed by cells undergoing programmed death as a result of the hormonal stimuli or a traumatic insult
+Expressed in all forming organs and supporting tissues in 10.5 to 14.5 dpc. Expressed in embryonic ectoderm and the forming brain and neural tube in 7.5 and 8.5/9.5 dpc embryos, respectively
+Expressed in the early embryo in ABpra/p and MSpa/p cells, with weaker expression in ABar descendants (PubMed:32273286). Expressed left-right asymmetrically in the embryo, in the mother cell to the MI pharyngeal motorneuron but not the mother cell of the e3D epithelial cell (PubMed:21041366)
+Expression starts at 5 dpc and gradually increases from P5 to adulthood (at protein level)
+Mostly expressed in anthers at the later stage of flower development until tapetum degeneration (PubMed:8220457, PubMed:23602096). In flowers, present in the anther tapetum early in anther development and later in the pollen coat (PubMed:11929861, PubMed:26305561). Upon tapetum degeneration, associated with tapetosomal debris 'in transit' to the pollen cell wall in the anther locule (PubMed:26305561, PubMed:23602096). Translocates from the pollen coat at exine cavities to the site of contact between the pollen grain and a papillar cell, called 'foot', 10 minutes after pollen landing; the pollen tube elongation initiates later (about 20 minutes after pollination) at the foot (PubMed:26305561)
+During the blastula period expressed in all blastomeres. At the onset of gastrulation, expressed more in the embryonic shield than in other regions. As embryos elongate, expression in the shield migrates toward the animal pole and forms a longitudinal band in the dorsal midline. At late gastrulation, expressed in the dorsal midline extending from the tailbud to the animal pole. Expression is under the control of Nodal signals
+During embryogenesis, is highly expressed at day 9.5 of gestation, and its expression decreases progressively during embryogenesis
+Expressed ubiquitously during embryonic development with prominent expression during the first 12 hours of embryogenesis
+Expressed primarily during lactation although very low levels are detected in a small percentage of non-lactating females (at protein level). Not expressed in late-pregnant or 1-day postpartum dams but high levels are found in 9-day and 20-day postpartum lactating dams with no expression 20 days after weaning (at protein level)
+In the developing brain, expressed at embryonic day 9.5 dpc in neuroepithelium, displaying a rostral-high/ caudal-low and lateral-high/medial-low expression pattern. Abundant at 15.5 dpc in progenitors of the ventricular zone and differentiated neurons in the cortical plate. The lateral-medial gradient spread further in all cells of the ventricular zone of the lateral cortex by 18.5 dpc (at protein level)
+By 8.0 dpc, expressed exclusively on the left side of developing embryos with expression predominantly in the prospective floor plate (PFP). Weak expression in the lateral-plate mesoderm (LPM)
+Can be detected by day 10-13 in ovo, the content is gradually increased throughout the ovo development and reached its peak after hatching
+Expressed in adult females and to a lesser extent in the second and third larval, and pupal stages
+Adult levels are reached by day 28 after birth
+First expressed at the 1-somite stage with an anterior expression limit in rhombomere 7 (r7) of the developing hindbrain. By the 15-somite stage, the anterior expression limit is at the r6/r7 boundary and this is maintained until at least 30 hours of development. At the 10-somite stage, weakly expressed in the paraxial mesoderm with an anterior expression limit at somite 1
+Expressed at 9.5 dpc onwards. At 10.5 dpc, in brain (telencephalic vesicles and isthmus), spinal cord and limb buds (in the zone of polarizing activity). At 14.5 dpc, in olfactory bulb and cerebellum
+Detected in intestine from 3 days post-fertilization onwards
+Strongly expressed throughout the whole embryo at 6.5 dpc, including the embryonic and extraembryonic ectoderm and endoderm (at protein level). Subsequently expressed in the ectoderm, endoderm and mesoderm at 7.5 dpc (at protein level). At 9.5 dpc, expressed in epithelia covering the first branchial arch and the coelomic cavity, the myocardium of the developing heart, the neuroepithelium and some extraembryonic tissues such as the visceral yolk sac (at protein level). Expression persists in a variety of epithelial tissues at 10.5 dpc. At 15.5 dpc, expression is lost in bronchial epithelium and becomes weaker in neuroepithelium, while increasing in the myotome of somites, the foregut epithelium, stratified epithelium and some kidney tubules (at protein level). At 17.5 dpc, expression persists in the myocardium and in the epithelium covering the body surface and skeletal muscles (at protein level). Expression is reduced during differentiation of ES cells. In adult primary myoblasts, barely detectable during proliferation, but dramatically up-regulated during terminal differentiation. Induced as early as 24 hours after differentiation signal and remains high as late as 7 days of differentiation. Little expression in resting muscle, but strongly up-regulated during regeneration of skeletal muscle fibers. Expression decreases when regeneration is histologically and functionally complete
+Expressed by late gastrula stage (stage 11)
+Detected at the dorsal midline at the level of the diencephalon and mesencephalon at 9.5 dpc. Detected at the level of the optic and otic vesicles at 9.5 dpc (PubMed:9545553). Detected in the lateral plate mesoderm surrounding the ventral aspect of the anterior foregut at 9.5 dpc (PubMed:19686689). Detected in the mesothelium encasing the lung, and at lower levels in the distal mesenchyme from 12.5 dpc to 14.5 dpc (PubMed:19686689)
+Expression begins after the mid-blastula transition (stage 8-8.5) becoming most abundant during gastrulation, then decreasing as development progresses. Expression remains at a very low level during the tailbud and tadpole stages
+During spermatogenesis, it is mainly expressed postmeiotically
+Expressed at stage 12 to 15
+During early larval development, peaking at the second larval stage, and dropping off in later development
+Expressed during prophase I of meiosis: detected from pachytene to diakinesis stages
+Expressed in 12.5 dpc embryos
+Expressed in 2-week old seedlings
+In the developing cerebellum expression is increasing in the first 3 postnatal weeks
+Expressed both maternally and zygotically. Highest level of zygotic expression seen in second-instar larva, level is reduced at other stages of development
+Expressed at a similar level during both the chronic and acute stages of infection (PubMed:31955846). However, transcripts are only translated during the chronic stage of infection, in response to stress conditions (PubMed:31955846)
+Low expression in fetal tissues
+Expressed in preimago stages, including early stage larvae, late-stage larvae, and pupae, but not in embryos
+Expressed in embryonic kidney
+Isoforms 1-X and 2 are expressed in embryos, larvae, pupae and adults. Highest expression is in late embryos
+The highest expression levels are seen during the previtellogenic period in virgin alate females, then decrease in reproductive females
+Expressed in the retina at 14.5 dpc
+Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma
+Third instar larvae and adult
+Expressed throughout the invaginating optic vesicles at stage 12, and uniformly throughout the neural retina from stage 14 to stage 18. Expressed in the spinal cord from stage 15 to stage 20
+Not expressed in seed development before 3 days after pollination (DAP), reaches a peak at 6 DAP and then decreases slightly (at protein level). In the caryopse, expressed specifically from the early to middle storage stage
+Expressed in anthers and microspores at floral stages 9 to 12, tapetum at floral stages 7 to 11, mature embryos at 5 days after flowering and dry seed embryos
+Expressed at much higher levels in the adult worm stage as compared to the cercariae and the egg stages
+Expressed in prestalk cells only during culmination and not at the slug stage. Expressed at high levels in pstO cells. Expressed precociously in mekA and erkA-null cells during early development. Precocious expression completely depends on the presence of smkA
+The earliest expression is detected at the junction of the epiblast and extraembryonic ectoderm, which is the initiation site for gastrulation. Around 6.5-6.75 dpc, expression becomes evident as gastrulation progresses. Expression does not spread over all mesodermal cells; it is seen only in a fraction of cells, particularly those in the early emergence group destined to become the extraembryonic mesoderm and the most posterior part of the tailbud. Expression remains for a while at the base of the allantois, and then spreads out to the lateral margins of the tail bud mesoderm. Expressed in the anterior presomitic mesoderm in a broad or thin stripe pattern. Expressed in the paraxial mesoderm during somitogenesis. Expression disappears before 8.5 dpc
+Isoform COL1 is expressed from 3 hours of embryogenesis, with a peak of accumulation between 8 and 16 hours post-fertilization. Expression persists at very low level in first instar larvae and accumulates again in third instar larvae and pupae. Isoform COL2 is expressed after 8 hours of embryogenesis, peaks in first instar larvae and is present at low levels in third instar larvae and pupae
+Expression is significantly lower in mature (egg-laying) females than in immature female, but unaffected by age in males
+First detected at 9.0 dpc in the first and second archial arches. At 10.0 dpc and 10.5 dpc, expressed in somites, especially the forming sclerotomes. At 12.5 dpc, found in dorsal root ganglia. At 16.5 dpc, expressed in bone-forming areas and adipose tissues, as well as in specific neural tissues. In bone-forming areas, expressed along the mesenchymal condensation at 14.5 dpc, in the perichondrium and in cells invading the cartilagenous structures at 16.5 dpc. In 18.5 dpc tibias, scattered throughout the trabecular/cancellous bone area. In vitro, expression is induced during differentiation of immature osteoblasts, and then declines
+First detected in 6 to 9 hour old embryos. Expression is highest in 9 to 15 hour old embryos. First detected in stage 11 embryos within the neurogenic region. Detected in the procephalic region, the ventral nerve cord, subesophagal, thoracic and abdominal ganglia in stage 13 to 14 embryos. Detected in embryonic midgut primordia. Barely detectable at the first stage of larval development. Not detectable in older larvae, pupae or adults
+Very low expression in vegetative cells, but increases dramatically at 4 hours after starvation and then rapidly falls to very low levels throughout the remainder of development
+Expressed at higher level in adult thymus, brain and lung, than in corresponding fetal tissues. Expressed at lower level in spleen, heart, kidney and liver during development
+Expressed at the early stage of germination
+First detected in the posterior region of the blastoderm embryo. In later stages of embryonic development, detected in the posterior portion of the midgut, in the developing malpighian tubules, in a subset of ventral somatic muscles, in the developing CNS and in Bolwig's organ
+Expression in the brain is detectable from 7 dpc, rises at 15 dpc and 17 dpc and peaks at P5. Enriched in the developing cortex, particularly in neuroblasts of the ventricular zone and postmitotic migrating cortical plate neurons. Interaction with DISC1 in the brain is developmentally regulated, peaking at 17 dpc and decreasing at P16 so as to be undetectable in the adult brain. Expressed in the testis from P12, when zygotene spermatocytes first appear, and expression subsequently rises at P27
+Expressed in neural progenitors and neuron cells throughout the developing nervous system. Expressed in somites and throughout the neural tube from 8.5 dpc, onward
+Accumulates in germinating seeds and in young seedlings. During the reproductive phase, strongly expressed in leaves and flowers. Barely detectable in stems, pedicels and siliques
+Periclinal cell divisions in the subepidermal layer of the awn primordium gives rise to a meristematic cushion in hooded phenotypes. Expressed before the formation of the cushion and continues as it is formed and in later stages its expression is down-regulated
+Predominately expressed in early developing neurons before the stage of neurite outgrowth and elongation. Then, expression strongly declines during neuronal development
+First observed in sepal primordia and floral meristems (PubMed:23314942). High levels in petal primordia and elongating petals margins but weak expression in the other floral organs (PubMed:23314942). In mature flowers, accumulates in the marginal region of petals and in ovules (PubMed:23314942)
+Expressed throughout development from blastocyst stage to embryonic day 16.5
+Expressed in embryonic, larval and adult stages
+Primarily detected in the vascular tissue of leaf and cotyledon petioles, and the hypocotyl of one week-old seedlings
+Expression is highest in oocytes, begins to decrease after fertilization by the 4-cell stage and then slightly increases up to the blastocyst stage
+Maternally expressed from the 4-cell stage and ubiquitously expressed through early embryogenesis, with enriched expression in the brain region at 36 hpf (hours post fertilization) (PubMed:24407421)
+Synthesis appears to be switched off shortly after hatching from the egg and invasion of the host. P18 is not found in unembryonated eggs, begins to be synthesized at about day 3 of development, reaches a maximal concentration with the formation of the first-stage larva and remains abundant in the perivitelline fluid of the second-stage larva
+Expressed in vegetative cells
+Found in the embryos, larvae and pupae. Expression in the adult heads is higher than in the bodies
+At stage 10, expressed in the neural tube throughout the mesoderm. By early stage 13, expression becomes restricted to the lateral mesoderm in the trunk region and in the cranial region, to the dermomyotome, to the somatic mseoderm-derived pericardium and to a group of cells located ventral to the dermomyotome. Expression continues at high levels in the dermatome. In later stages, high expression found in the limb bud mesenchyme pharyngeal arches, the maxillary arches and the frontonasal mass and to a lesser extent, in the aorta, cardiac valve mesenchyme, the pericardial wall and the ventral foregut wall
+Detected in the extraembryonic region of the visceral endoderm of pre-streak and early-streak embryos. Detected in the extraembryonic region of the visceral endoderm and in the definitive endoderm at 7.5 dpc. By the seven to eight somite stage, detected in the posterior endoderm, mainly in the endoderm of the midgut and hindgut invagination. Expressed in spermatogonia. The expression clearly declines from the early pachytene spermatocyte stage onward. In contrast, expression of isoform 2 (T-SOX17) begins at the pachytene spermatocyte stage and is highly accumulated in round spermatids (PubMed:11973269). Detected in arterial endothelium in embryos and yolk sac at 10.5 dpc (PubMed:24153254)
+CAPK activity is low in vegetatively growing amoebae, increases during development of aggregation and reaches a maximum at culmination
+Produced during mid embryogenesis, and imaginal disk morphogenesis
+Expressed in pubertal and adult animals but not in immature animals
+Present at similar levels in the mammalian bloodstream form and the insect procyclic form
+Expressed after stage 19 (late neurula)
+First detected at 9 dpc in highly restricted regions of the neural tube, in caudal myotomes, and at the materno-embryonic junction of the uterus. At 10 dpc, restricted expression is detected in the optic and otic vesicles, the roof of midbrain, and trunk myotomes. By mid-gestation (13 dpc to 16 dpc), expression in the developing nervous system has expanded to multiple regions including hippocampus, thalamus, hypothalamus, brain stem, and spinal cord. Expression is also detected in several peripheral organ systems, including gut, lung, adrenal and kydney primordia
+Expressed at high levels in GV- and MII-stage oocytes, as well as in 2-cell embryos. Levels drop sharply by the blastocyst stage (at protein level). Not detectable in fetal ovaries 90 and 95 days of gestation, but highly abundant in fetal ovaries of late gestation
+First expressed at stage 25. Expression peaks at stage 28 and continues at this level throughout all later stages, until at least stage 38
+Up-regulated during xylem vessel element differentiation
+Found at very low levels at day 10 and levels increase at day 15 and persist throughout adulthood
+Expressed at all developmental stages. Detected in globular to heart stage embryos
+First expressed in two extraembryonic mesodermal derivatives, the yolk sac and the allantois in 8.5 dpc embryos. Localized to the embryonic red blood cells within the yolk sac blood islands
+During larval development, expression is first detected in the mid-gastrula stage and increases thereafter (at protein level)
+Expressed both maternally and zygotically. Accumulates in previtellogenic oocytes and is maintained at constant level throughout oogenesis and into early embryogenesis. Declines through gastrula to neurula. Not detectable between neurula and tailbud, nor in adult tissues other than ovary
+Expressed at high levels at 6 hpf. Expression levels remain high through 18 hpf and 28 hpf in many developing tissues suCh as vascular structures or epidermis. By 48 hpf, expression is restricted to the head. At 5 dpf, expression is restricted to epidermis
+Expressed in the developing intestine both prior to and during remodeling (stages NF54 to NF66). Also expressed at high levels in the tail during tail regression (stages NF62 and NF64) and in the hindlimbs during hindlimb morphogenesis (stage NF56)
+Expression increases gradually from post-natal day 1 to week 2, increases significantly from week 2 to week 4 and remains high thereafter
+Synthesized throughout vegetative growth. Synthesis is enhanced during stage II of sporulation and in stage IV mother cells. Undetectable in stage IV forespores. Present in the inner forespore membrane of the dormant spore
+Found in embryos at 0-2 hours of development, levels decrease drastically at 6 hours of development but increase again at 12 hours of development
+Expressed throughout the whole embryo at all stages of development examined. At day 10, highest expression is found in the yolk sac while at day 16 and 18, higher levels are found in inner compartments of bone. In the embryo, highest expression of isoform 1 is found at day 11 while highest expression of isoform 2 is found at day 7
+Expressed in the prestalk cells and prespore cells. Expressed only late in development. First detected in the finger stage and expression levels peak in late culmination (18-22 hours). Its expression ceases upon cell disaggregation but is fully restored by exogenous cAMP after a 5 hour delay
+First expressed in the first differentiating cardiomyocytes of the cardiac crescent at 7.5 dpc and in the first somites at 8.0 dpc. In the heart, expression is restricted to the myocardial compartment. In the developing forebrain and cerebellar primordium, strictly expressed in post-mitotic neurons
+Expressed in the early developing nervous system, with the exception of prominent gaps in the mid-hindbrain and the fore-midbrain boundaries. By 10.5 dpc, expression in the nervous system decreases slightly and a segmented pattern of expression appears, marking the ventral sites of somitic buds. At that stage, the expression shows a strong dorsal to ventral gradient. In the neural tubes, strong expression is detected at the level of the floor plate and in the medial portion of the neural tubes. Lower expression is detected in the dorsal neural tube and the ventral aspect corresponding to the area of motoneuron differentiation. In the developing eye, expressed in the perioptic mesenchyme
+Expressed at high levels at the early stages of pistil development (stages 1 to 6) and disappears towards anthesis (stages 7 to 12). At stage 4, observed in the stigmatic secretory zone, including the papillar cells, and in the stylar transmitting tissue. Expressed in stigma and style specialized tissues at initial stages of flower development
+Expressed in larvae during the L3/L4 molting stage, specifically in both the old and new cuticles (PubMed:8939969, PubMed:16186127, PubMed:15555728). In L3 larvae, expressed in the hypodermis, the basal lamina of the pseudocoelom, the glandular part of the esophagus and in cells of the epidermal cord (PubMed:8939969, PubMed:15555728)
+On 15 dpc embryo the level of isoform Gamma exceeded that of isoform Alpha and isoform Beta and decreased after birth. On P10 post neonatal, the level of isoform Gamma is undetectable and isoform Alpha and isoform Beta are expressed again
+In the embryo, expression is detected at 10.5 dpc, increases continuously through to 17.5 dpc and is also high in neonates. Down-regulated in adults
+At 9.5 dpc, detected in the developing heart, skeletal myotomes and dorsal portion of the neural tube. At 13.5 and 15.5 dpc, expressed in the heart and neural tissue including the central and peripheral nervous system. In the embryonic brain, expression is restricted to more mature neurons and absent from the progenitor neuronal cells of the ventricular zone. Also present in mature peripheral neurons, such as the neurons of the dorsal root ganglia and the Auerbach's and Meissner's plexi of the intestinal tract
+Mainly expressed in developing brain
+Highly expressed in young vegetative and reproductive tissues, including calli, roots, seedlings, internodes, leaf blades and coleoptiles as well as young panicles and kernels. But low levels in 3-week-old sheaths and reproductive organs. During early spikelet development, accumulates in inflorescences, especially in the outermost cell layers. Present strongly in the palea and lemma epidermal cell layers, mostly at the position of the interlock. Also observed in reproductive organs, such as stigmas, stamens, lodicules, young kernels and seed coats
+Abundantly expressed in 14.5-day fetal liver. Expression decreases during late liver development and stays at low levels until birth. Expression increases 24 hours after birth and reaches highest levels in adult liver
+Appears after germination and maintained at high levels in rapidly growing tissues
+Expressed during the S phase
+Ubiquitous expression in elongating root hair and non-hair cells prior to hair formation
+Expressed both maternally and zygotically with expression levels remaining constant throughout development
+Ubiquitously expressed throughout development (at protein level) (PubMed:24933177). Expressed in early embryos in utero, in the pharynx and body-wall muscles during larval stages, becoming prominent in coelomocytes and the male tail in young adults (PubMed:24933177)
+Detectable in early embryos. Present coincident with bicoid/bcd expression, with peak levels detected in 0-2 hours embryos. Expression is lower during cellularization stages (2-4 hours) and drops dramatically during late embryonic development (4-24 hours). Very little, if any expression is detected in unfertilized eggs
+During pollen development, expressed in mature pollen grains and early in pollen-tube growth. Not expressed in immature pollen grains and fully grown pollen tubes (PubMed:24198233). During embryo development, expressed from the heart stage to mature embryo. Not expressed at the beginning of embryo development up to the globular stage (PubMed:24198233, PubMed:24453164)
+Expression increases during muscle differentiation (at protein level) (PubMed:20473270). In the lens, expressed at high levels throughout embryonic and early postnatal stages and then gradually diminishes to adulthood (at protein level) (PubMed:35472217). In the developing embryonic heart, expression is significantly increased at 11.5 dpc and 12.5 dpc (PubMed:33913477)
+Expressed at embryonic day 7, but not later in embryogenesis. Expressed in adult
+Expressed as early as 8 hours after infection
+Expressed during embryonic development and also detected a week after birth. Expression decreases by 14 days after birth and is not detected in the adult (at protein level)
+In embryo, expressed during the initial stages of germ band exclusively within the neuroectoderm, both in the territory of the trunk and in cephalic regions. During stage 9, expressed within the procephalic lobe and the ventral ectoderm
+Expressed throughout embryonic and larval stages and in both adult males and females (PubMed:16262702). Expression is very low during the pupal stage (PubMed:16262702)
+First expressed prior to the start of aggregation, becoming concentrated in the slug anterior. Later is expressed in the maturing spore head of the fruiting body
+Expressed in zygote at the one-cell embryo, markedly less abundant at the two-cell embryo
+In oocytes, expression levels increase from germinal vesicle immature oocytes to metaphase II (MII) and decline after fertilization in 1-cell and 2-cell embryos (at protein level) (PubMed:25050112). At 7.5 dpc, highly expressed in all embryonic cells and extraembryonic tissues, including ectoplacental cone, chorion, extraembryonic endoderm and parietal endoderm (at protein level) (PubMed:27179789). At 8.5-9.5 dpc, widely expressed (PubMed:8948440). At 8.5 dpc, levels decrease in extraembryonic tissues (PubMed:27179789). As development proceeds, expression becomes more restricted. At 11.5 dpc, most abundant in the neural tube, but still expressed at moderate levels in a number of other sites, including the mesenchyme of limbs and the face and in liver. At 14.5 dpc, highly expressed in the developing brain and caudal neural tube, but absent from the marginal layer of the neural tube. Also expressed in the developing metanephros and lung. At 15.5 dpc, expressed in the brain and spinal cord, as well as in teeth primordia, the lung and in the developing limb (PubMed:8948440). At 16.5 dpc, moderate, but non-uniform expression levels in the placenta (PubMed:27179789)
+Expressed in germinating seeds 48 hours after exposure to the light, just after the emergence of the radicle
+Expressed in adult, not neonate-specific as in other organisms
+During larval development, expression is low during early stages and gradually becomes higher in late stages
+Expressed in early blastula stage embryos with a decrease during gastrulation. Expressed at early neurula stage in two broad wedge-shaped domains within the neuroectoderm flanking the midline. Throughout neurula stages, the anterior limit of its expression is maintained at a position posterior to hindbrain rhombomere 5. Confined to the trunk region of the prospective CNS. At stage 26, expressed in a gradient spanning the presumptive hindbrain/spinal cord boundary, the diencephalon, the pronephros and the presumptive olfactory placodes. From late neurula stage on, its expression becomes detectable in a distinct population of emigrating cranial neural crest (CNC) cells of the third branchial arch. At stage 26, expressed in the entire hyoid and branchial arch region and strongly reduced in this domain at tailbud stage
+Detected at all stages of development, during early embryogenesis and in oocytes, in larvae and adults
+Expressed above the root elongation zone, but not in the root primordium
+At postnatal day 1 (P1), in cartilage growth plate, primarily expressed in resting and proliferating chondrocytes. This expression pattern is maintained at least until P21 (at protein level)
+Strongly expressed in brain and eye from 12 dpc to 17 dpc. After birth, brain expression decreases, whereas eye expression remains stable
+It is synthesized during oogenesis and persists during early cleavage. It accumulates at gastrulation (stage 10), peaks in quantity during neurulation (stage 17), then drops to a low level after stage 26. Isoform 1 is strongly expressed in branchial arches and to a lesser extent in the neural floor plate, but is not expressed neither in the pre-somitic mesoderm nor notochord. At gastrula stages 10-11, isoform 2 is mainly found in ectoderm and mesoderm with greater expression in the prospective dorsal side. At neurula stage, expressed anteriorly in the head mesoderm and in the archenteron roof. In early tadpole stage, expressed in head mesenchyme and in the tailbud
+Expressed only in the early stage of lactation. Decrease in expression correlates with a change in the sucking pattern of the young
+Expressed in eggs, L2 stage and in adult. Expressed at lower level in L1, L3 and L4 stages
+Highly expressed in pollen grains at all floral stages and in pollen tubes at anthesis (PubMed:29288621). Observed in transmitting tracts along pistils, nectaries and ovules, and in the entire pistils at anthesis (PubMed:29288621). In anthers, present in pollen and tapetal cells (PubMed:29288621). Accumulates in imbibed pollen grains and in germinating pollen tubes (PubMed:29288621). Detected in embryo sacs at stages 13-14 (PubMed:29288621). During embryogenesis, expressed from the globular stage to the mature stage in the embryo but not in the endosperm, especially in the embryonic root meristem (PubMed:31341004). Accumulates also in trichomes on rosettes and stems, and the vasculature in roots (PubMed:29288621). In developing seeds, expressed in the basal suspensor cells and chalazal seed coat at the heart stage of embryogenesis, and in the radicle and cotyledons of mature green embryos (PubMed:29288621). In leaves, strongly expressed in vascular tissues (PubMed:31341004). In roots, detected in root tips, mostly in the root stem cell niche and columella cells (PubMed:31341004). In flowers, accumulates in styles, petals and anther filaments (PubMed:31341004). In siliques, present in funiculi (PubMed:31341004)
+During embryonic stage 16-17, expressed in accessory cells of all ciliated mechanosensory and chemosensory organs (at protein level). Specifically, detected in the cap cell of chordotonal organs and the shaft cell of external sensory organs (at protein level). Also detected in chemosensory organs including the pharyngeal organs, dorsal organ, terminal organ and ventral organ (at protein level). Expression appears to be temporally restricted to late embryogenesis and is not detected during larval stages (at protein level)
+Expressed during oogenesis and eggs. Up-regulated by polyadenylation during meiotic maturation (at protein level)
+Low levels in germinating seedlings and in young cotyledons (PubMed:17158605). In young roots, restricted to the steles (PubMed:17158605). In mature leaves, confined to the edge areas (PubMed:17158605). Also detected in undeveloped floral side buds, in petals, and in filaments (PubMed:17158605)
+Highly expressed in the central nervous system (CNS) in both the brain lobes and the ventral cord throughout embryogenesis, from early stages of neurogenesis. Expressed in both neuroblasts and neurons. Expressed at lower level in the visceral mesoderm during stage 12. Expression of DIP2 overlaps with that of Disco in the visceral mesoderm and CNS
+Expressed bpth maternally and zygotically
+Expressed in embryo and in larvae
+Expressed both maternally and zygotically. Detected from stage I oocyte up to the tadpole stage. Present at a relatively high level until the gastrula stage, after which expression levels decrease. During gastrulation, levels of protein activation are highest in the embryonic mesodermal region
+Expressed in developing lymphocytes and neural cells. Maximal expression is found in pre-B-lymphocytes
+Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation
+First detected at day 15.5 of gestation in the embryo, where it is expressed in the newly forming granular layer of the skin. Is found in stomach at day 17.5
+Detected in the day 2 fifth-instar larva, wandering larva, pupa and adult
+Expressed in the germ ring including the shield at shield stage and in the tailbud at 10-somite stage
+Expressed in the anthers and the upper parts of the stamen filaments after stage 7 to 9 of flower budding. In stage 10 flower buds, expressed in the anthers and pollen grains. Weakly expressed in mature flowers at stage 12
+Expressed late in development and immediately prior to spore formation and in spores during culmination
+Found in somatic cells of ovarian cords throughout the fetal ovary development
+Detected throughout embryogenesis. Expressed ubiquitously in 8.5 dpc embryos. At 10.5 dpc, strongly expressed in nervous system including hindbrain and spinal cord, and in the pharyngeal arches and visceral organs. By 14.5 dpc, strong expression is detected throughout the central nervous system, and in tongue, heart, midgut and urogenital regions
+During pollen development, accumulates progressively in uninucleate microspores (UNMS) and bicellular pollen (BICP) to reach a maximal peak in immature tricellular pollen (TRCP), and fades out in mature pollen grains (MPGR) (PubMed:21705385). Strongly expressed in germinating pollen (PubMed:21705385)
+Pre-spore specific
+Localized to the coleorhiza, outer cell layers of the radicles, and the root caps of the developing embryo. Later found in the root tip and root cap
+Expressed at moderate levels in the central nervous system of stage 13-14 embryos. Highest levels at this stage in fiber tracts from dorsal root ganglia and trigeminal ganglion to the spinal cord as well as in fibers on both sides of the Purkinje cell layer of the cerebellum. Expression is down-regulated during postnatal stages P6 to P10 followed by up-regulation at the onset of myelination. High level expression in most myelinated axon tracts of the adult including cerebellum, pons, medulla, and spinal cord as well as in nonmyelinated fiber tracts in the striatum lucidum CA3 region of the hippocampus
+Induced by seed imbibition with a peak at day 2 and then declines steadily until day 8
+Newborn
+Expressed in sympathetic ganglia and trunks at 13.5 dpc, 15.5 dpc and P1. Up-regulated during myocyte and adipocyte differentiation (at protein level)
+First detected at the shield stage of gastrulation in the involuting mesendoderm with levels being highest in the paraxial mesoderm and decline laterally to become undetectable in the ventral mesoderm. Expression spreads in the hypoblast towards the animal pole and converges dorsally. At the tail bud stage (9.5 hpf), transcripts are seen in adaxial cells flanking the future notochord and in the presomitic mesoderm (PSM). During early somitogenesis, expression also extends into the future head, in two stripes continuous with the adaxial cells. Expression continues under the hindbrain as far as the midbrain/hindbrain boundary, in the presomitic mesoderm (PSM), trunk adaxial cells and somites. Expression still found, in the early pharyngula stage. in the PSM and adaxial cells in the tail and, at 33 to 70 hpf, strong expression in the pharyngeal arches and saggital sections
+Expression is very low in embryonic epidermis at 13.5 dpc and increases from 14.5 dpc to 16.5 dpc. In young mice expression increases in the testis of 2 to 6 weeks old animals, and then remains stable
+Expression of PCM5 and 8 reduced during tuber development
+Expressed from day 7.5 in the primitive streak. At day 9.5, it is expressed in various neural and mesodermal derivatives, mainly along dorsal neural tube, diencephalon, somites and tailbud mesoderm. Strongly expressed in limb buds, particularly in the morphogenetically active region such as the apical ectodermal ridge (AER)
+Expression is seen from 3-fold embryonic stage onward
+Abundant in neonatal brain, but not in adult brain
+The amounts of these transcripts increased significantly during submerged sporulation. The smaller protein is made in lower amounts during sporulation
+Expressed in the exponentially growing phase. Level decreases down to an undetectable level during stationary phase
+Detected at stage 15 in the presumptive dorsal-limb ectoderm. At stages 16-18 expression is restricted to the dorsal side with higher concentration at the dorsoventral boundary and later in the AER. Expression remains restricted to the dorsal ectoderm and the AER until stages 22-24 when it starts to fade in the dorsal ectoderm, but remains in the AER until the last stage examined (27)
+In skin, expression starts shortly after birth and reaches a first maximum at 9 days. A second peak of expression is observed at 3.5 weeks, then levels decline and remain low in the adult. In the developing mammary gland, expression is detected exclusively at the onset of puberty
+At 14.5 dpc, highly expressed in the mid- and hindbrain and only weakly in the forebrain, but during development the main expression shifts towards the telencephalon as seen at 17.5 dpc (PubMed:16099729). In cerebellum expression is highly up-regulated between postnatal days P7 and P12. At P7, low expression levels throughout the brain, but high in hippocampus, thalamus and the cerebellar white matter (PubMed:17984326)
+Accumulates during aging (PubMed:23915037, PubMed:21471330). In young seedlings, expressed in hydathodes of new emerging leaves and cotyledons as well as in vascular tissues of new emerging leaves and in cortical root cells at the division/elongation transition zone (PubMed:31862580). Observed in shoot apex, in hypocotyls and hypocotyl/root junction (PubMed:31862580)
+Expression is first seen at the base of the emerging first two true leaves but not of the cotyledons. As leaf development progresses expression begins in the base of the petiole and gradually extends toward the whole midrib and later it is restricted to the vasculature of the petiole and leaf blade and disappears as the leaf matures
+Expression begins at embryonic day 8.5
+Detected only during early meiosis prophase I (early 4N-fraction containing leptotene, zygotene and few pachytenes spermatocytes) and not during later stages of meiosis (at protein level)
+Predominantly expressed during the initial cleavage and blastula stage. Little expression in the further development
+Expressed in the embryonic myocardium: not expressed in the myocardium at 9.5 dpc but is present in epicardial cells. At 10.5 dpc, expressed in the mesenchyme surrounding the ventral foregut and in regions enriched in cardiac progenitors, as well as the epicardium and lining of the pericardial cavity. By 12.5 dpc, expressed throughout the myocardium and ventricular trabeculae
+Expression first detected at 5.0-6.0 dpc in the extraembryonic region, at 7.5 dpc detected within the chorion; later the expression is expanding to the entire embryo
+Expressed during late embryogenesis in embryos but not in endosperm
+Expressed during early embryo development, from the eight-cell stage until the end of the heart stage
+Present at high levels in the pineal gland early in development and decreased steadily thereafter
+Expressed throughout embryogenesis and early larval development, predominantly in hypodermal cells, especially ventral P cells and their descendants
+Expressed from 10.5 dpc onward mainly at epithelial-mesenchymal interfaces in kidney and other tissues undergoing morphogenesis (at protein level)
+At stage 11.5 dpc ubiquitously expressed (PubMed:28413018)
+Expressed in the seed coat inner integument layer facing the endosperm in the stages from globular to torpedo embryo
+Expressed in embryo, larva, pupa and adult (at protein level)
+Predominant at the juvenile and adult stages
+Accumulates in upper part of roots, hypocotyls and cotyledons of developing embryo. Levels increase in early stages (torpedo, 4 days after flowering) and decrease during late stages of embryo development
+At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 8. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 7/8 boundary
+Maximally expressed 4-6 hours after starvation (around the aggregation-stream stage), followed by a drastic decrease from the mound to tipped aggregate stage
+It first appears on the chromosome loops and in the nucleoplasm of the germinal vesicle (GV). It is transmitted to the egg at GV breakdown and appears in embryonic nuclei at the mid-blastula stage and is found in many but not all nuclei at still later stages of embryogenesis
+Detected at low concentration in practically all the fetal tissues and its expression markedly and rapidly decreased after birth
+Detected at 15 dpc, P1, P7, P14, P36 and in adult cerebellum in all neuronal populations. Peakes at P7 in hippocampus, increases linearly from P1 to P36 in cerebellum, and shows minimal developmental regulation in cerebral cortex. At 15 dpc, also detected in dorsal root and peripheral ganglia. In cerebellum, the transcript is present in the molecular, Purkinje and granular layers with higher expression in the molecular layer at P14
+At 12.5 dpc and 13.5 dpc is expressed in the endothelial cells of forming lymph sacs
+Expressed during the asexual blood stage (PubMed:25784701). In the mosquito vector, expressed in oocyst sporozoites, and salivary gland sporozoites (PubMed:25784701)
+Expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation. At 12.5 dpc, highly enriched in the postmigratory pyramidal neurons forming the cortical plate situated beneath the pial surface. At 13.5 dpc, expressed in the ventricular zone and subventricular zone at low levels, expression is much higher in the developing cortical plate, where postmitotic neurons are positioned. During late embryonic and early postnatal development, expression disappears from cortical progenitors and becomes restricted to the subplate and the prospective layer V and VI pyramidal neurons
+First observed at low levels in the vasculature and around hydathodes of developing leaves. In flowers, restricted to anthers tapetum at a post-meiosis stage, to filaments, and to microspores during their development. Disappears as pollen matures. In developing roots, expressed throughout the lower part, in the cap, in the epidermis and in non-epidermal tissue in the division and elongation zone. Also detected in cells lining lateral root formation
+Present in the chloroplasts of light-grown mesophyll cells and in the plastids of dark-grown upper hypocotyl endodermal cells possessing large starch granules (PubMed:34367195). In dark-grown hypocotyl epidermal cells that lack starch granules, localized to plastids stroma (PubMed:34367195)
+More abundant in promastigotes than amastigotes
+Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair
+Not expressed until 10 hpf. Expression gradually increases from 10 to 36 hpf and is maintained at high levels thereafter
+Expressed in embryo, larva, pupa and adult (PubMed:7706258, PubMed:7759483). Expressed at very high levels in early cleavage stage embryos at 0-2 hours followed by lower expression at 2-6 and 6-10 hours of embryogenesis (PubMed:7706258). During later stages of embryogenesis at 10-14 and 14-18 hours, expressed again at high levels, particularly in muscle fibers (PubMed:7706258). Very low levels in larval and pupal stages (PubMed:7706258)
+Highest expression in sexually differentiated cultures and conidia when there has been exposure to light. Also expressed during vegetative growth
+Expressed zygotically from the blastula stage (stage 8) and peaks in the gastrula with lower expression persisting into tailbud stages
+Up-regulated during seed germination and leaf expansion
+First detected at low levels at 10.5 dpc in cranofacial mesenchyme and in parts of the nervous system. At 12.5 dpc, high expression found in heart, diaphragm, bronchi and in the mesenchyme surrounding precartilage condensations. At later stages, expressed in dental papilla, dermis, hair follicles and in the perichondrium and in regions containing chondro and osteo progenitor cells
+Expression is dynamic during early embryonic development, with ubiquitous somatic expression occurring between the 50- and 200-cell stage (PubMed:16457801). By the late proliferative phase of embryogenesis, expression is reduced, but maintained at high levels in muscle precursors (PubMed:16457801). Later in embryogenesis, moderate expression occurs in the lateral ectoderm (PubMed:16457801). Pharyngeal expression is very low at both the comma and 1.5-fold embryonic stages (PubMed:16457801). Expression is highest in muscle and neuronal cells in larvae and adults, including many of the amphid neurons that are proximal to the posterior bulb of the pharynx (PubMed:16457801). Consistent expression in cells of the somatic gonad including distal tip, sheath, and spermathecal cells, as well as in vulval cells undergoing morphogenesis (PubMed:16457801). Neuronal expression in the midbody includes the CAN, HSN, and ALM cells; neurons of the ventral and dorsal cords; and a number of posterior deirid neurons (PubMed:16457801). Expressed in all pairs of coelomocytes (PubMed:16457801)
+Expression in the epidermis of floral primordia changes through development from being weakly expressed in the youngest the floral organs, with possibly a stronger expression on the abaxial side (P1, P2 stage) to being relatively strongly expressed in both the adaxial and abaxial epidermis at later stages
+Expressed immediately after gastrulation in the polster, cranial ganglia, rohan-beard neurons and in ventromedial cells of the spinal cord at 12 hours post-fertilization (hpf). Expressed in cells slightly anterior to the segment border at 16 hpf
+Expression is highest in petals at stage 2 of flower development (when the top of the bud is open, flowers are 6-9 mm in length and almost pigmented)
+Higher expression is detected in unfertilized eggs and one-cell embryos compared to two-cells embryos and adult tissues (PubMed:21654807). In the embryo, expression is detected at 10 dpc becoming stronger by 11 dpc and continuing through to 16.5 dpc
+Expressed in preleptotene spermatocytes, pachytene spermatocytes, round spermatids and elongated spermatids (at protein level)
+Expressed in embryos at 8 dpc, onward (PubMed:15226444). Expressed in the allantois and throughout the neuroectoderm and paraxial mesoderm at 8 dpc (PubMed:15226444). Expressed in the chorion and blood vessels at 8.5 dpc (PubMed:17013884). Expressed in the neural tube, paraxial mesoderm, heart, brain, otic vesicle and yolk sac at 9.5 dpc (PubMed:17013884). Expressed in embryonic stem cells (ESC) (PubMed:15226444)
+Expressed in all brain areas analyzed from embryonic (18 dpc) and adult mice
+3 EF-1-alpha are expressed under different developmental control in Xenopus laevis. This protein is expressed exclusively in immature oocytes
+Isoform C is detected in the later blastula period, 4 hours after fertilization. Isoform D is not detected at this stage, it first appears during the gastrula period in 8 hours old embryos. Expression of both isoforms is then maintained throughout development. During later developmental stages, prominent expression is seen in regions where tissue compartments are continuously moving in relation to each other
+First detected in fetal skin around day 16 and expression continues throughout newborn and adult stages
+Expressed during development. Expressed during aggregation and shows a marked decrease in fruiting bodies
+Absent from maturing black cherry fruits until 6 weeks after flowering. Then, concomitant with cotyledon development, the level of enzyme increases with specificity for embryonal tissues
+In the cotyledon, expression is not detected until 10 days after fertilization. Between 10-19 days after fertilization, expression increases rapidly but declines 20-30 days after fertilization. 30 days after fertilization, no expression occurs. This expression pattern closely parallels the rate of sucrose uptake in the cotyledon
+Maternal protein detectable up to 6 hours of embryonic development
+Expressed during late development in prespore cell
+In roots, mostly expressed in the stele and young epidermis cells and, to a weaker extent, in endodermis, cortex and differentiated columella cells
+Expressed from the oblong to the hatching stage
+First expressed in the brain around embryonic days 13-14, and peaks by postnatal day 20
+Expressed in the developing cells of the embryo including hypodermal cells, neuroblasts, and mesodermal cells (PubMed:15572126). Expressed in seam cells in hermaphrodites at the L2 stage of larval development (PubMed:25569233)
+Recruited to centrioles at the onset of the centrosome duplication cycle, then associates with the emerging daughter centriole
+During mid-embryonic gestation, expressed abundantly in liver, less in heart and brain. Highest expression at day 14.5
+Expressed at 9.5-10.0 dpc in limb buds, pharyngeal arches, tail bud, placenta and neural tube (PubMed:9927193). Up-regulated during adipocyte differentiation (PubMed:14701838)
+In roots, present in both the quiescent center (QC) and the root apical meristem (RAM); within the meristem, mainly present in the cortex but also in the epidermal and procambial cells closest to the QC, with very strong levels in the initials surrounding the QC (PubMed:23370719). Also present in the QC, and the first and second columella cells (CC) layers (PubMed:23370719). Induced early during lateral root formation (PubMed:23370719). Detected in the vasculature of cotyledons and leaves (PubMed:23370719). In the shoot apical meristem (SAM), present at the border between the meristem and the leaf primordia (PubMed:23370719). In flowers, accumulates in the vasculature of sepals, stamens, and petals as well as at the tip of the gynoecium and later in the siliques (PubMed:23370719)
+Expressed throughout development from embryos to adults (PubMed:9741628, PubMed:15238518, PubMed:27650246). Not expressed in somatic cells of embryos (PubMed:28806108). First expressed in 1-cell embryos, and expression persists until the 4-cell stage (PubMed:15238518). Expression diminishes in somatic blastomeres, but remains in E and P3 blastomeres at the 8-cell stage, in P3 blastomeres at the 15-cell stage, and in P4 blastomeres at the 24-cell stage (PubMed:15238518). Expressed in the primordial germ cells Z2 and Z3 during the two-fold stage of embryogenesis (PubMed:15238518, PubMed:27650246). Levels are low in young larvae but increase at the end of larval development (PubMed:9741628). Expressed in germ blastomeres (PubMed:19377305)
+Expression peaks during embryogenesis and lowest during larval stages
+First expressed at 12 dpc and then expression declines postnatally. Highly expressed in the developing CNS (at protein level)
+Expressed only in non-mature oocytes
+Expressed both maternally and zygotically. Maternal expression declines during cleavage and blastula stages with zygotic expression increasing from gastrulation. From neurula stage onwards, expression levels are relatively constant
+Expressed in the developing septum and ovule primordia during the early stages of flower development
+Expressed in the spinous and granular layers of the tongue at P20
+Expressed in 1, 2 and 4-cell embryos (at protein level) (PubMed:10983990, PubMed:30279189). Expression increases between P0 (the zygote) and P2 blastomeres due to its asymmetric segregation in P1 and P2 blastomeres, its degradation in somatic cells and its translation in the P lineage (at protein level) (PubMed:30279189)
+Widely expressed in fetal brain
+Expressed in the 4 descendants of the D blastomere in embryos at about the 185 cells stage and in many other unidentified cells located more anteriorly
+Expression gradually increases from late embryonic (18 dpc) stage until adulthood
+First expressed in the pachytene spermatocyte stage (PubMed:1893875)
+Expressed in fetal brain and fetal liver
+Expressed both maternally and zygotically. Embryos exhibit ubiquitous low level of expression until stage 11 and then expression becomes spatially and temporally restricted to areas of PCD
+Expressed in somatic tissues throughout the larval stages and in adults
+Expressed in embryo, placenta and amniotic membrane at 10.5 dpc (PubMed:17942406, PubMed:25888968). Expressed in placenta at 9.5 dpc and appeared to increase as gestation progresses peaking around 12.5 and 15.5 dpc (at protein level) (PubMed:16341224, PubMed:25888968). Expressed in embryo at 9.5, 12.5 and 16.5 dpc (PubMed:11574691). Expressed in developing musculo-skeletal system, during skeletal myogenesis and also in precartilage primordia and derivative chondrogenic cells of the developing skeleton (PubMed:11574691). Expressed in mesenchymal tissues of developing lung, kidney, gonad, gut and placenta (PubMed:11574691). Not expressed at stages of chondrocyte hypertrophy and ossification of bones (PubMed:11574691). Expressed in all extraembryonic tissues at 9.5 and 12.5 dpc and low-level expression in the embryonic brain and vertebral cartilage at 12.5 dpc (PubMed:11574691)
+Expressed in most cells of the embryo beginning from the 100-cell stage (at protein level) (PubMed:20230814). Expressed throughout larval development in the excretory system, anterior neurons and the hypodermis (at protein level) (PubMed:20230814). Expressed in vulval precursor cells and their descendants during the mid-larval stages and is highly expressed in the somatic gonad from the L3 larval stage to adulthood (at protein level) (PubMed:20230814)
+Expression starts at 10.5 dpc and reaches a plateau of expression at 12.5 dpc
+After pupae formation, expressed during centriole-to-cilium basal body conversion and in the early phase of ciliogenesis in neurons, then disappears (at protein level)
+Expressed in the developing cerebellum at constant levels from 18 dpc to P7
+Expressed in embryo in subcutaneous white adipose tissue from 16.5 days post coitum (dpc) to 4 days postnatal (P4). Expressed early in pups in visceral epididymal white adipose tissue at 4 days postnatal (P4) and strongly decreases from P7 to P56 (at protein level)
+Highest levels are found after 10 hours of development. Levels decrease during multicellular development (at protein level)
+Detected only after the second postnatal week
+Present in dark-grown plants it increases upon exposure to light
+Expressed on the surface of extra- and intraembryonic hematopoietic cells, neural tube, aorta, glomerulus, liver, heart and coelomic cavity in 4 day old embryo; in each of these tissues, detection is restricted to cells comprising the lumenal surfaces of tissues or boundary elements between tissues such as in the liver capsule, aorta, mesonephros, coelomic cavity and the central canal of the neural tube. Expressed in multipotent progenitors of day three yolk sac (at protein level)
+Expressed broadly in the third instar larvae and adult flies (at protein levels)
+Present in larva (at protein level)
+Strong up-regulation during the S-phase
+Repetitive stimulation of naive T-cells, including with IL2 and antibodies against CD3 and CD28 or repetitive antigenic exposure, leads to progressive and irreversible loss of expression
+Widely expressed in the embryo. Expressed in embryonic aorta and pulmonary arteries from 12 dpc to 19 dpc
+During embryonic development unc-51 is expressed extensively, particularly in the head region of late embryos. In the larval stages, expression appears to be restricted to neurons
+Expressed at the notochord and the somite around tailbud stage. At 14 hours post-fertilization (hpf), expressed in the somites, notochord, and the brain. Found in the rhombomere 3 (r3) and r5. Expressed in the optic vesicles and a region covering the caudal diencephalon and the mesencephalon with the strongest expression at its most anterior part. Mesodermal expression is observed in both forming and formed somites. In forming and newly formed somites, transcripts are distributed evenly. In contrast, distribution in somites located on more anterior trunk seems to be uneven, strongest in the ventral, intermediate in the dorsal, and weakest in the medial parts. At 23 hpf, there is no expression in the medial parts of somites. Expression in somites fades away by 36 hpf. At 20 hpf, additional expression is detected in the pharyngeal arches
+Up-regulated in differentiating neuroblastoma cells
+Expressed in fetal lung (PubMed:9070861, PubMed:9077527). Expressed in fetal calvaria and to a lesser extent in fetal kidney and skeletal muscles (PubMed:9593714, PubMed:9077527)
+In young seedlings, observed in shoot apices and roots and accumulates gradually in the leaf vasculature (PubMed:22492352). Later expressed in inflorescence apices, especially in the center, and in secondary inflorescence meristems (PubMed:22492352). In floral buds and flowers, strongly present in anthers (specifically in the tapetum), ovules and pollen (PubMed:22492352)
+Expressed in neural cells during enbryogenesis. From 11.5 dpc until 14.5 dpc, it is mainly expressed in the forebrain. From 15.5 dpc until birth, expression in the forebrain becomes weaker but is still observed in the olfactory bulb and the skin around the eyes, nose, limbs and tail, showing that its pattern of expression changes from the central nervous system to the peripheral tissues during development
+Expression is dramatically up-regulated at the wandering stage. Low expression at fifth instar larva (day 1), prepupal, pupal (days 1 and 2) and adult stages (PubMed:18959754). Expression is up-regulated before each molting stage during development of the late fourth instar larva (4L), late fifth instar larva (5L), prepupa (PP), and late pupa (P3). The expression level reaches its peak at the fifth instar day 5 (5L5) and prepupa stages, and the level is about 10 times higher than that of fifth instar day 3 (5L3) larva. At the 5L3 stage, expression levels in the integument and alimentary tract are similar. However, at the 5L5 stage, the expression level in the integument is up-regulated more than 3-fold, but remains unchanged in the alimentary tract (PubMed:21106526)
+Expressed in the G2/M phases. Remains high in early G1 phase
+Increased levels in liver during prenatal development
+Expressed in cortex and cerebellum throughout the postnatal period (at protein level)
+At the vegetative stage, strongly expressed in the shoot meristem, leaf primordia and juvenile leaves. At the reproductive stage, localized in the young developing flowers
+Similar levels from 7 dpc to 17 dpc in whole embryo and brain. In the cerebellum, expressed most strongly in dividing cells of the external granule layer
+Expressed only in female gametocytes following emergence from red blood cells
+Expression is detected between the 10 s and 48 hour post-fertilization stages
+Higher expression during spermatogenesis from the mitotic stages to the meiotic stages
+Expressed at all stages of development (PubMed:8441382, PubMed:8670823). Expressed in most embryonic tissues and larval tissues at the early stages (PubMed:8670823). Highly expressed in neurons, pharynx, the hyperdermis and body muscles in L1, L2, L3 and dauer larvae (PubMed:8670823). From the L4 stage of larval development and in adults, expression is mainly restricted to the nervous system, but is also expressed in the pharynx and hyperdermis (PubMed:8670823). Expressed in the linker cell, a male-specific cell which guides the elongation of the gonad, about 1-2 hours before induction of linker cell death (PubMed:26952214)
+Expressed in urogenital ridges of mice at 9.5 dpc. Expressed in the nervous system at 10.5 dpc. Expressed in the forelimb and hindlimb buds, the caelomic cavity at the level of the urogenital ridge, including the gonads, the pancreas and liver epithelium at 11.5 dpc. Expressed widespread throughout the CNS alar neuroepithelium from 11.5 to 14.5 dpc. Expressed in pioneer neurons of the cerebral cortex. In the telencephalic vesicles, expressed in cerebral cortex, the hippocampus, the claustrum primordium, olfactory bulb primordium and the caudal ganglionic eminence (amygdaloid complex) at 13.5 dpc. In the diencephalon, expressed in the pretectum (p1 prosomere), the dorsal thalamus (except for a thin ventral band close to the alar-basal boundary), the epithalamus, the epiphysis in prosomere p2, the supraoptic-paraventricular area, the eminentia thalami (p4 prosomere), the retrochiasmatic area and the tuberal hypothalamus at 13.5 dpc. In the mesencephalon, expressed in the tectum, the walls of the hindbrain, in nuclei of the ventral midbrain and hindbrain at 13.5 dpc. In the spinal cord, expressed as a gradient in the dorsal part of the neuroepithelium at 13.5 dpc. In the neocortical neuroepithelium, expressed in the archicortex (in the dentate gyrus, CA3 and CA4), the diencephalon, the midbrain and hindbrain at 14.5 and 16.5 dpc
+During seedling development, expression is high at 1 day after imbibition and then declines continuously to reach steady levels after 5 days
+Highly expressed in dorsal root ganglia of the developing brain at 12.5 dpc (at protein level)
+Expressed in spores (PubMed:24355926). Expressed in germlings (PubMed:24355926)
+Seems to contribute mostly when the bacteria reach stationary phase
+Expressed during matrix production and maturation. Also expressed during myocyte differentiation
+Expressed in the gut during embryogenesis (PubMed:14648222, Ref.3). Expressed in presumptive intestinal cells and in unidentified cells in the head prior to embryonic elongation (PubMed:14648222). Highly expressed in the most anterior intestinal cell from 1.25-fold stage to 2.5-fold stage (elongating) embryos, but weakly expressed in the remaining intestine in embryos at the 1.25-fold stage (PubMed:14648222). Expressed in additional unidentified cells in the head in 2-fold stage embryos (PubMed:14648222)
+Found at all developmental stages
+Expressed in roots developing protophloem, up to the end of the transition zone
+Present at constant levels throughout development
+Undetectable in the blastula. Appears with gastrulation, is present throughout neurulation and organogenesis, and decrease to barely detectable levels in hatched larvae
+Detected as early as embryonic day 10
+Broadly expressed at 16.5 dpc
+In the testis, expression is highest in fetal gonad, then decreases 5-fold in newborn. Detectable in 7-day-old but not in 21-day-old or adult
+Peak of expression after light treatment at 9 days of seedling development
+Found at leading edges of lamellipodia and at sites of cell-cell contact in stationary stage cells. Also present in filopodia. Largely disappears from lamellipodia and cell-cell contact regions in aggregation stage cells, suggesting the occurrence of a developmentally regulated relocalization to the cytoplasm
+Expressed in the atria and ventricles throughout postnatal development and in adults
+In the knee joint, detected in articular cartilage from 2 weeks of age but not at earlier stages (at protein level). Initially localizes to the surface zone of articular cartilage but by maturity (8 weeks) is found in the intermediate to deep zones (at protein level)
+Expressed from 8 dpc throughout embryonic development, with levels increasing at 12.5 dpc and remaining constant thereafter. Up-regulated during chondrocyte maturation and skeletogenesis
+Most highly regulated expression during conidiation
+Expressed in the germline during gametogenesis: expressed at all stages of spermatogenesis, with elevated expression observed in pachytene spermatocytes (PubMed:28867294). During oogenesis, expressed at all stages of folliculogenesis: expressed both in the oocyte and in somatic granulosa cells (PubMed:28867294). Also expressed during oocyte maturation, with abundant expression in germinal vesicle as well as in meiosis II oocytes (PubMed:28867294)
+Expression increases continuously throughout embryonic development
+First detected at 18 dpc, expression increases with growth and development in spite of a temporal decrease at P14. Still expressed in adult animals, in both the cerebrum and the cerebellum, although at lower levels in adults than in younger animals (at protein level)
+Expressed in the embryo and throughout all stages of development to adulthood
+In skin, levels decrease gradually from the telogen (resting) phase of the hair follicle with lowest levels observed in late anagen IV phase of active growth (at protein level)
+Expressed both maternally and zygotically. Levels are high during embryogenesis and in the larvae but decrease in the pupae before increasing again in the adult
+Expression detectable in day 8.5 embryos
+Expressed specifically in the prespore cells
+Expression is first detected in the testis at 3 weeks and continues to adulthood
+Haploid stage of the germ cells
+Primarily expressed in differentiating cells. Also expressed in the proliferating cells of the developing CNS and the epidermis. In the spinal cord at embryonic day 10.5, expressed in the ventricular zone of the neural tube. Expressed at highest levels in cells accumulating in the intermediate zone. At 11.5 and 12.5 dpc, highly expressed in the intermediate zone and at reduced levels in the ventricular zone that mostly persists in the dorsal part of the neural tube. At 14.5 dpc, expressed throughout the spinal cord. In the developing epidermis at 14.5 dpc, found in the dorsal lateral epidermis. At 17 dpc, expression is restricted not only to the differentiating cells of the epidermis but also to the proliferating cell compartment and expression extends into the first differentiating cell layers, but decreases in the uppermost layers of the epidermis
+Expressed ubiquitously at low levels during embryonic development
+Expression starts at the pediveliger, foot formation, stage
+Expressed at 17 dpc in the brain with levels remaining relatively stable up to adulthood (at protein level)
+Expressed during the parasite blood stage
+Strongly expressed in the shield, the floor plate in early somitogenesis, the posterior neural plate, the otic vesicles and later in the otoliths, the pronephric ducts, diencephalon, olfactory pits, briefly in the trigeminal ganglion, and in an anterior brain region that overlaps the pineal gland and later corresponds to the anterior tectal ventricle
+Isoform D is expressed during embryonic development
+Expressed at low levels in somite derived structures. In the developing eye, marked the ocular musculature. Expressed in all differentiating muscles of the limb and the body wall, but not in migrating muscle precursor cells. Not detected in the nervous system, either at 9.5 dpc or at any stage later during development
+Widely expressed in 8.5 dpc and 9.5 dpc embryos with a more restricted expression pattern at 13.5 dpc-15.5 dpc. In general, expression in embryos coincides with areas of actively proliferating cells
+Only present in the striated muscle cells of the medusa stage
+Expressed in developing seeds from 5 to 20 days after flowering (DAF)
+Expressed in round spermatids belonging to stages V to VII/VIII with no visible expression in earlier or later stages
+Expressed 3 days after germination, with a gradual decrease before the floral transition and remains at low levels afterward
+Expressed throughout all the development stages. Isoform 2 is not expressed until 48 hours post fertilization
+Expressed throughout the embryo up until 8.5 dpc with strong expression in the neural tube. Expression continues throughout the embryo with some intense expression also in the epithelium of the intestine, skeletal muscle, lens, retina, cranial nerve, and dorsal root ganglion cells. After birth, strong expression in the epidermis, hair follicles, epithelium of the digestive and respiratory tracts, and kidney tubules
+Expressed in neonatal and adult neutrophils
+Isoform 1 is expressed throughout development. Isoform 2 is expressed at low level during vegetative growth. Expression of isoform 2 increases rapidly during aggregation (1-4 hours) and remains high throughout development
+Detected as early as 12.5 dpc, expression peaks between postnatal day 1 and day 7 and decreases at week 8 after birth (at protein level)
+Widely distributed throughout the adult forebrain. Prominent expression was observed in the neocortex, the piriform cortex, the pyramidal cell layers of hippocampus, the dentate gyrus, in several nuclei of the thalamus and hypothalamus and in the amygdala
+Expressed in the nascent mesoderm of gastrulating embryos. At 7.0 dpc expression detected in both the intraembryonic mesoderm and the extraembryonic mesoderm cells of the amniotic fold. At 8.5 dpc expressed predominantly in the head mesenchyme, allantois, and the mesodermal layer of the amnion, chorion and yolk. In 9.5 dpc embryos highly expressed in the mesenchymal tissues, presomitic paraxial mesoderm, heart and branchial arches
+Expressed in dorsal D (DD) motor neurons in L2 and L4 stage larvae
+In floral tissues, expressed in pollen grains and fertilized ovules until they develop into seeds, and, at low levels, in the styles. Observed in germinating seedlings, and later confined to shoot and root apical meristems
+Maximum expression between 18 and 28 days after pollination
+Transiently expressed during four-cell to morula stages in embryo
+Expressed from the larval stage onwards throughout the adult stage
+Presents exclusively in early embryonic and germline cells (PubMed:15771630, PubMed:21314676). Expressed in both spermatogenic and oogenic cells except for round spermatids and the later stage (PubMed:12112575). Expressed in early stage embryos and decrease after the gastrula stage (PubMed:12112575)
+Induced by 25 days after anthesis (dAA), peaking at 45 dAA but decreasing considerably thereafter
+Isoform gamma is the only family member developmentally expressed. Expressed throughout the brain in 15.5 day embryos and in cranial nerve cells, skeletal tissues such as neural crest-derived face bones, and the periphery of cartilaginous skeletal elements including the rib and vertebrae anlage. On day 17.5, expression was observed throughout the brain, trigeminal ganglion, cranofacial bones, oral-facial structures, cervical vertebrae, axis and the ileum. Expression continued in the vertebral column throughout ossification
+Expressed during early spermatogenesis
+Expressed in 14.5 dpc in several cartilaginous structures including anlagen of several bones and the developing lungs as well as in the eye, ear and colon. First detectable at 12.5 dpc. At 14.5 dpc localizes to cartilage, developing dermis, cornea, the inner limiting membrane of the retina, and major arteries of the heart. At 18.5 dpc appears restricted mainly to cartilage where expression continued into adulthood
+Detected at 6.5 days post coitum (dpc) in the developing central nervous system (PubMed:17207666). At 7.75 dpc, expression is limited to the headfolds (PubMed:17207666). At 8 dpc, transcripts are detected in the midline neural groove (PubMed:17207666). Between 8 dpc and 9.5 dpc, it is found in the developing forebrain, brainstem, spinal cord, branchial arches, otic vesicles, midbrain and hindbrain folds (PubMed:17207666, PubMed:17353115). At 10.5 dpc, expression is detected in the telencephalic vesicles, branchial arches, otic vesicles, dorsal root ganglia, somites, spinal cord and forelimb buds, specifically in migratory muscle progenitor cells (PubMed:17207666). At 11.5 dpc, it is detected in telencephalic vesicles, midbrain-hindbrain boundary, the spinal cord, branchial arches, dorsal root ganglia, fore- and hindlimb buds and somites (PubMed:17207666, PubMed:17353115). Also detected at 11.5 dpc throughout the wall of the telencephalic vesicle and the medial and lateral ganglionic eminence (PubMed:17353115). At 14.5 dpc, expression is detected in the entire cerebral cortex, with higher levels in the developing hippocampus and septal area (PubMed:17207666). Expression becomes more graded by 16.5 and 18.5 dpc, where it is detected in the caudal and medial cerebral cortex, hippocampus and retrosplenial cortex (PubMed:17207666). Detected at 16.5 dpc in female genital tract (PubMed:17353115). It is also detected in the olfactory bud at 18.5 dpc (PubMed:17207666). Detected at 9.5 dpc in embryos (PubMed:20219459). Detected from 7.5 dpc in the brain, with highest levels of expression being detected at postnatal day 1 (PubMed:27621227). Expression remains at high levels at postnatal day 7 and begins to decrease by postnatal day 14 (PubMed:27621227). Expression is decreased further by postnatal day 30 (PubMed:27621227)
+Expressed throughout floral primordia at stages 1 through 4. At stage 6 and later, expression is confined to reproductive organ primordia. At stages later than stage 10, localizes in developing ovules and anther locules
+Expressed in embryo Carnegie stage 18 in Rathke's pouch progenitors
+First expressed at the 2-somite stage as a stripe in the region of the hindbrain that will give rise to rhombomeres 2 and 3. By the 10-somite stage, expression has expanded posteriorly to rhombomeres 4 and 5
+In the embryo, expressed from the heart stage to dry seeds. In germinating seeds, expression decreases during imbibition and increasees again 72 hours after imbibition, during the establishment of the seedling
+At 12.5 dpc, it is expressed in differentiating fiber cells in the posterior lens, but not in the anterior epithelium of the lens (AEL)
+Expression coincides with the onset of programmed cell death (PCD) at all stages of embryonic development, particularly in the head
+Increased expression during seed maturation (after 29 days after fertilization)
+Expressed from early gastrula stage and remains constant throughout neurulation and organogenesis. Expressed throughout the ectoderm of early gastrula. During gastrulation, it is detected in the marginal zone in both deep and superficial layers but is excluded from the Speemann organizer. At late gastrula, it persists in lateral plate mesoderm and becomes detectable in the anterior neural plate. At stage 15, it is expressed in 2 longitudinal stripes along the neural plate, in the anterior neural plate, and in lateral and posterior mesoderm. At tailbud stage, it is restricted in several regions of the brain, including diencephalon and midbrain-hindbrain boundary, pronephros and dorsal neural tube. Also detected in the dorsal- and ventral-most portions of somites, the drosal fin and the proctodeum. Expression in the brain of late tadpoles is mainly restricted to diencephalon, including the zona limitans intrahalamica
+Muscle-specific expression increases in adults between day 3 and day 11
+Present from 12.5 dpc, although at this stage, protein levels are low. In the male, from 12.5 until 14.5 cpc, it localizes to the cytoplasm of germ cells, but from 15.5-16.5 dpc, it localizes to the nucleus as well. In the female, it is cytoplasmic in germ cells throughout embryonic gonad development (at protein level). In testis, low levels are observed in the early stages of meiotic prophase I (leptonema to midpachynema). Starts to accumulate throughout the cytoplasm and in prominent perinuclear nuage in late pachytene and diplotene spermatocytes. Meiotic metaphases and secondary spermatocytes show a high level in the cytoplasm as well as in nuage. Present in the chromatoid body and in a second smaller nuage in round spermatids (at protein level)
+Expressed during hair follicle morphogenesis, with highest expression levels detected at late anagen stage of the hair follicle cycle (PubMed:11316781). Expressed in developing brain from embryo to adult (PubMed:16876275). In placenta, detected at 8 dpc, peaks at 10 dpc and declines thereafter (PubMed:10537154)
+Isoform 1: at 5-7 weeks of gestation, detected primarily in the cytotrophoblast layer. By 10-13 weeks, expression becomes restricted primarily to the apical border of the syncytiotrophoblast (PubMed:19942931). Isoform 2: expression significantly increased around 6-8 weeks (PubMed:15775999)
+Levels decrease slightly from young developing leaves to mature ones (at protein level)
+Detected in the brain at 18.5 days post coitum (dpc), with expression increasing till it reaches its peak expression at 28 dpc
+Is present in the fetal thymus as early as day 14 of gestation. The levels are 5- to 10-fold higher in thymocytes than in peripheral T-cells, and increase in the thymus during development from neonate to adult
+Detected in all organs of the plant and at all stages of the life cycle. Detected 1 day after germination in the radicle just before its emergence from the seed. At 2.5 and 3 days after germination, expression in the young seedling is highest in the cotyledons and the root tip. At 3, 4 and 5 days, expression is also detectable in the hypocotyl. At 10 days of age, expression in the first pair of true leaves is reduced relative to the rest of the seedling. 2 days later, this difference disappears and the expression level is again fairly similar throughout the aboveground portion of the plant, with a higher intensity in the vegetative apex. This developmental regulation is not detected in leaves developing at later nodes. Older plants also display uniform expression throughout the vegetative organs, but this expression is less intense. In older seedlings, expression is observed throughout the root, particularly at the tip of the primary root and in lateral roots. Expression is also observed in trichomes and senescing leaves, and in inflorescence internodes, flowers. Expression is observed in the seeds and carpels of fully elongated siliques. Lower expression is also observed in expanding siliques and in the developing seeds in these siliques. Expression is also detected in the embryo of maturing seeds (after the disappearance of the endosperm) (at protein level)
+First detected at 15 dpc. Expression increases gradually throughout embryonic development and peaks at postnatal day 10. Expressed at 17 dpc in the eye and the deep layers of the cortex. At postnatal day 6, expression is restricted to retinal glanglion cell layer in the eye
+Expressed throughout development, with slightly higher levels of expression in 0-12 hour embryos and adult females
+NUDT16 mRNA concentrations are elevated 10-fold in the endometrium of sheep from day 5 to 9 of the estrous cycle and return to basal levels by day 11
+Expressed throughout development (PubMed:14646593, PubMed:12642658, PubMed:16002472, PubMed:15073152). Highest levels of expression in adults and early embryos (PubMed:15073152, PubMed:14646593). First detected in 0-2 hour embryos, likely due to a maternal contribution as it is not detected during the rest of embryogenesis (PubMed:15073152). Expressed in third instar larvae, throughout pupal development and in adults (PubMed:15073152)
+Expressed in the subplate of the embryonic cortex and the axonal tracts in the intermediate zone, and in axonal tracts of projection neurons, specifically in the corticothalamic tract and the corpus callosum (at protein level). Isoform 2 is transiently expressed in the neocortex and hippocampus from 17 dpc to P7 (at protein level). In embryonic brain, present in all divisions of the central and peripheral nervous system and it is at least 5 times more abundant than other FHFs. Detected in the subplate, ganglionic eminences, and proliferative zones of the cortical wall at 14 dpc. Detected in the cortical plate of the cerebral cortex, hippocampus, and striatum from 17 dpc to P14. Expression is markedly reduced in adult brain where it is most abundant in hippocampus. Also detected in developing kidney. Expressed in developing chandelier neurons
+Expressed during ovule development in the inner and outer integuments. Not detected in young panicles
+Found in the majority of L1 larvae and in all L2, L3 and L4 larvae and adults showing medium to high expression. Highest levels found in older adults
+Expression is greatly increased in leaves during leaf senescence
+Expressed both maternally and zygotically during embryonic stages
+Expressed throughout development and in adults (at protein level). Expression peaks in early embryos (2 h after oviposition), then steadily decreases over the embryonic and larval stages (at protein level). Expression increases again 5 days after oviposition and remains stable until day 10 (at protein level)
+Not expressed at the embryo stage
+Expressed predominantly during early stages of germination with maximum level at 12 hours after imbibition and at the latter stages of silique maturation. Accumulates in dry seeds
+Detected in embryonic brain at 13 dpc. Levels in brain decrease gradually after 15 dpc, but expression continues after birth (PubMed:21673655). Detected in embryonic myocardium, body wall and pro-epicardial organ at 9.5 dpc. Detected in the epicardial cell layer and throughout the myocardium at 10.5 dpc. Highly expressed in embryonic and neonate heart, but after that levels decrease strongly, and the protein is barely detectable 3 weeks after birth, with even lower levels after 7 and 15 weeks (at protein level) (PubMed:21350012). Detected in the anterior endoderm at 7.5 dpc. Detected on anterior somites, the allantois and mesenchymal tissue behind the developing heart at 8.5 dpc (PubMed:18448090). Detected in the cephalic mesenchyme and in tissue posterior to the developing heart at 9.5 and 10.5 dpc. Detected in the developing stomach and in a subset of the trunk sclerotome at 10.5 dpc. At 11 dpc, detected also in branchial arches, eyes and limbs (PubMed:16872596, PubMed:18448090)
+Detected at each embryonic stage, the highest expression level observed at 11 dpc
+Strongly expressed at 9.5 dpc in the telencephalon, thalamic areas of the diencephalon, heart and liver
+Peak expression is seen in early stationary phase
+Expression (mRNA and protein) is highest in uteri on days 3 and 4 during early pregnancy
+Expressed during embryogenesis mainly in embryonic epidermis
+Expressed in dorsal undifferentiated neural cells in the spinal cord at stages 8 and 23 (at protein level). Expressed in the dorsal neural tube along almost the entire rostrocaudal extent and dorsomedial somites at stage 8. Expressed in the dorsal hindbrain, spinal cord, midbrain and forebrain at stage 17. Expressed in somites and the dorsal CNS at stage 23
+Expressed in the root maturation zone and, transiently, in emerged lateral roots
+Widely expressed in embryonic tissues, including strong expression in the central nervous system
+Expressed from hatching to adulthood. Expressed in dauer larvae
+In placenta, detected at 8 dpc, peaks at 12 dpc and declines thereafter
+At 14.5 dpc, strong punctate expression in the otic mesenchyme. Detected in the cells lining the lumen of the primitive cochlear duct and in the nerve fibers of the spiral ganglion, as well as in the nerve fibers invading the cochlear epithelium. At 17.5 dpc, detected only in the mesenchyme around the cochlear duct. 2 days after birth (P2), the mesenchymal expression becomes weaker, except in the region of the spiral limbus, while expression is observed for the first time in the apical region of the developing pillar cells (PCs). Also observed in the cytoplasm of outer hair cells, in their innervating nerve fibers and in the marginal cells of stria vascularis. At P9 and P12, detected in the stria vascularis and strongly through the entire length of the inner and outer PCs. At these stages, in tissues of mesenchymal origin, restricted to the spiral limbus and the spiral ligament. At P14 and P16, strong expression is maintained in the PCs and in the marginal cells of the stria vascularis, weak expression in the spiral limbus and ligament. Also detected in Deiter's cells. At P19 and P22, intense expression in the PCs and stria vascularis, as well as in the cell bodies and processes of Deiter's cells. Weak expression in the spiral limbus and ligament. At P31, when the inner ear is functionally mature, expressed only in the PCs and stria vascularis. At P69, strong expression in the PCs and less intense in stria vascularis. In the vestibular maculae and the cristae ampullaris, expression similar to that observed in the cochlea: strong signal in the mesenchyme at the initial embryonic stages that progressively becomes weaker and is less prominent in the adult (P33). At 17.5 dpc and P2, observed in nerve fibers innervating the sensory epithelia. Expression in the vestibular epithelium starts at 17.5 dpc and is readily detected at P2. Later expression increases and persists in adult stages in which it is restricted to the apical cytoplasm of the epithelial cells (at protein level)
+Isoform 2 is expressed in brain, heart and liver throughout embryonic development. Isoform 1 is mainly expressed in neonatal developing ventricular cardiomyocytes
+Expressed in mature flowers and decreases upon pollination
+Expressed in the apical region (growing zone) of the root hair. Expressed in the growing region of leaves. Expressed in developing seeds
+Peak of expression around the time of early inflorescence
+Expression was relatively weak during all of the embryonic stages. At 14.5 dpc, a slight increase in the expression could be observed in heart, CNS, and PNS. At 18.5 dpc, it is strongly expressed in the inner ear, hair cells and in the head muscles. No expression is detected in the nasal epithelium or in the skin keratinocytes
+Expressed at different stages of development between 7 dpc and 17 dpc, and highest expression seen at 11 dpc. Detected in the liver at 13.5 dpc and strongly expressed in the cephalic mesenchyme and roof of the hindbrain, lining of the pericardial cavity and atrial chamber of the heart and lumen of the stomach in 11.5-day embryos
+Highest expression at mid-pregnancy
+The earliest expressed of the Irx family, with expression seen in trophectoderm-derived extraembryonic tissues from 6.5 dpc, including expression in the chorionic ectoderm at 8.0 dpc. Embryonic expression starts at the end of gastrulation (7.5 dpc) in the ectodermal layer which gives rise to the nervous system. At 8.0 dpc, expression is confined to the thickening neural ectoderm corresponding to the future mesencephalon (midbrain) and rhombencephalon (hindbrain) and from 8.5 dpc onwards, expression also includes the rostral part of the closing neural tube. After neural tube closure at 9.5 dpc, expression predominates in the CNS in the midbrain, hindbrain and spinal cord. Also expressed in a number of tissues outside of the CNS including ectodermal layer of the branchial arches. Expressed in the prospective limb buds of the lateral plate mesoderm, and from 10.5 dpc onwards a gradient exists along the dorsoventral and proximodistal axes of developing limbs. Expressed in the notochord at stage 9.0 dpc. At 9.5 dpc found in the cephalic mesoderm surrounding the optic vesicle. Around 10.5 dpc, expression in the head mesoderm extends into the nasal pits. By 12.5 dpc, still expressed in the mesenchyme, and expressions begins in specific subsets of post-mitotic cells in the neuroretina. As development ensues, expression increases in the neuroretina and mesenchymal expression gradually decreases. At 16.5 dpc, expressed exclusively in the inner neuroblast layers of the neuroretina. In the developing heart, first expressed in the trabecules of embryonic ventricles at 9.5 dpc, and from then onwards localizes specifically to the trabeculated myocardium of the ventricles
+Expression begins during meiotic prophase
+Expression first detected at 5.0 hours post fertilization (hpf) in the dorsal blastoderm margin. Through the stage of embryonic shield formation, expression is restricted to the hypoblast, in the region of cells fated to become head and lateral plate mesoderm and pharyngeal endoderm. At 18 hpf, when the heart tube is beginning to assemble, three domains of expression can be seen: cardiac precursors, pharyngeal arch precursors and otic vesicle. These three domains remain the sites of expression to varying degrees through at least 72 hpf. By 51 hpf, expression can be seen in the cardiac outflow tract, the ventricle and the atrium, although by 72 hpf cardiac expression is strongest in the cardiac outflow tract
+Expression at least from 7.5 dpc onwards throughout embryonic development with lower levels at 7.5 dpc and 9.5 dpc. Ubiquitously expressed at 11.5 dpc
+Not detected during G1 phase. First detected during S through G2 phases, and peaks during mitosis (at protein level)
+Early embryos (up to four blastomere stage)
+Expressed in all embryos during the early cleavage stages until the 100- and 200-cell stage, after which, expression diminishes. During larval development, first expressed in L1 larvae, but it is not highly expressed in the germline. Expression in the germline increases at later larval stages
+Overexpressed in a subset of human mammary tumors
+Expressed both maternally and zygotically. Expression increases during oocyte growth and continues at a constant level until the tailbud stage (at protein level)
+In seedlings, observed at high levels in the vasculature of cotyledons, first true leaves, and hypocoty. In flowers, expressed in the vasculature of sepals, petals, and style. In the paraclade junctions between the primary stem and axillary stems, mainly detected in the vasculature of cauline leaves
+Specifically expressed in gut, fat body and Malpighian tubules of sugar-fed larvae
+Expressed predominantly at the S-phase of the cell cycle
+Expression was detected at very low level in liver from 1 day-old and then gradually increased to the maximum level at 4 weeks old
+Regulated during the cell cycle: protein levels increase 10 to 20 fold in the late G1 and decrease at the S/G2 border
+Expressed ubiquitously during development in central nervous system, imaginal disk, fat body, gut, and to a lesser extent in Malpighian tubules
+Expressed in a replication-independent manner. Strong expression in the generative cell of early bicellular pollen, but not detected in late bicellular and tricellular pollen
+No obvious expression before embryo hatching but is probably expressed at later stages (at protein level)
+Expressed in postmitotic neurons during the stage of development in which extensive axon pathfinding is occurring. At 14 dpc, expressed in both spinal cord and dorsal root ganglia. Present on the sarcolemma in postnstal day 1 (P1) gastrocnemius muscle. By P8, becomes more concentrated at the junctional sites and by P21, colocalizes with acetylcholine receptor clusters
+Expressed in embryos from the early gastrula stage (stage 10.5). Peak expression occurs at neurula stages (stages 11 to 17), with progressive reduction from the mid tailbud stage (stage 24) onwards. Still expressed in swimming tadpoles (stage 40) and in adults
+In the embryo, expression increases slightly from day 9.5 to day 11.5, remains almost constant until day 14.5 and then decreases
+Expressed between approximately 30-70 hours after egg lay at 15 degrees Celsius and between 15-35 hours after egg laying at 25 degrees Celsius relating to mid-L1 to mid-L3 stage of larval development
+Expressed throughout development and in the adult
+Expression was detected in 7 dpc embryos. Expression levels decreased at day 11 and remained low at days 15 and 17
+Expressed throughout the erythrocytic development of the infected host, low expression in rings and schizonts, high levels in trophozoites
+Highest levels in young developing leaves with a sharp expression decrease in fast-growing and mature leaves (at protein level)
+Ubiquitous throughout embryogenesis. Highly expressed in stage 3 embryo indicating that it is maternally provided. After stage 15, it is more prominent in the central nervous system
+Expression increases during embryonal development at 11 dpc, 15 dpc and 17 dpc
+Highly expressed during embryonic development and during the first three weeks after birth. Expression is low in adults
+During flowering, preferentially expressed in mature anthers
+The KAP6 proteins are first expressed in differentiating hair shaft keratinocytes, a considerable distance above the proliferative zone of the follicle bulb
+Expressed from embryogenesis to the first instar larval stage, then at the pupal stage. Not expressed at significant levels in the adult
+First transiently detected in the nascent mesoderm at the onset of gastrulation. A second site of expression is detected at 8 dpc in the rostral region of the presomitic mesoderm inmediately before segmentation. Down-regulated immediately after the formation of the segmented somites before 13.5 dpc. Initially expressed throughout the length of one somite, and then quickly repressed in the presumptive caudal region. Mesp2 is involved in the rapid down-regulation of its own expression in the presumptive caudal half of the somite
+Expressed by preodontoblasts and odontoblasts in developing teeth. Localizes to the apical pericellular regions of preodontoblasts. When the dentin matrix is fully formed and dentin mineralization occurs, it is present in the predentin matrix and along the dentinal tubules. It is also expressed in the developing growth plate cartilage, hair follicles and extraembryonic areas of the placenta
+Expressed in spermatocytes in the pachytene stage of the first meiotic prophase
+The strongest expression is seen in very small leaves (less than 1 cm in length) and decreases steadily as leaves become older. There is approximately 4- to 6-fold stronger expression in sink leaves relative to source leaves. Only minor variations in expression are seen during early stages of tuber development, however expression declines with increase in tuber size
+Expressed during gastrulation and during a second phase in some adult tissues
+Expressed in the endoderm and ectoderm cells of the caudal pharyngeal region at 8.5 dpc
+Continually expressed in both embryogenesis and postembryonic organ development. Strongly expressed in actively dividing or elongating cells but only weakly or not at all in differentiated tissues other than the vasculature
+Expressed in dorsal root ganglia at 15 dpc onwards
+In far-red light (FR)-treated seeds, mainly observed in the radicle of the embryo (PubMed:22483719). Accumulates upon red light (R) in cotyledons (PubMed:22483719)
+Detected in all examined tissues of L3 instar larvae. Expression in the ring gland and anterior spiracles increases during development. In the ovaries it is predominantly expressed in one pole, and in the anterior spiracles it is mostly expressed in the spiracular gland. Ubiquitously expressed throughout the testis and alimentary tract
+At 5 dpf, expressed in larvae brain and spinal cord
+Expressed from the 1-M to 4-M stage of mesodermal M lineage development during the larval development
+Expressed both maternally and zygotically. Maternal expression is weak and zygotic expression is strong by the 30% epiboly stage. At the gastrula stage, expressed in all prospective neural tissue with the exception of a band of cells in the prospective midbrain and hindbrain. At the tail bud to 3-somite stage, expressed in distinct regions of the future brain, the anterior margin of the neural plate and the primordia of the epibranchial placodes. At the 12-somite stage, broad expression in the central nervous system (CNS), with weakest expression at the forebrain-midbrain and midbrain-hindbrain boundaries and in the posterior CNS. At the 21- to 25-somite stage, broad expression in the CNS and the lens
+During embryonic stem cell differentiation, expression peaks at d2 and d3 (epiblast stage) (PubMed:16546155). In postimplantation embryos widely expressed throughout 6.5-7.0 dpc, followed by higher levels of expression in the headfold neurectoderm at 7.5 dpc (PubMed:16546155). At 8.5 dpc, observed in the neural tube and optic vesicles (PubMed:16546155). At 9.0-9.5 dpc, expressed at sites of imminent neural tube closure in the midbrain, hindbrain, and tailbud and in the dorsal aspects of the somites (PubMed:16546155). At 9.5 dpc, expressed within the neuroepithelium surrounding the telencephalic, mesencephalic and optic vesicles and in neural crest cells on either side of the mesencephalic vesicles, along the neural tube continuous with the tailbud, in the neural crest-derived dorsal root ganglia, in the surface ectoderm of the branchial arches as well as the primitive gut tube (PubMed:20563991). At 11.5 dpc, predominantly expressed within the forebrain, eye and neural tube, and weaker expression within the optic and oropharyngeal regions, in the epithelium of the olfactory pit, optic stalk and otic vesicle, parts of the gut tube, particularly within the lumen of the midgut loop and the stomach, in branchial arches and in the condensing mesenchyme of the developing limb buds (PubMed:20563991). At 11.5 dpc, also expressed within the neuroepithelium surrounding both the fourth and telencephalic ventricles (PubMed:20563991). At 13.5 dpc, expressed throughout the developing nervous system with most prominent expression in forebrain, midbrain and spinal cord, including the dorsal root ganglia and the olfactory bulb and within the endoderm derived midgut loop in the physiological umbilical hernia, as well as in the eye and in the main bronchi of the lung and within the developing metanephric tubules (PubMed:20563991). At 13.5 dpc, also expressed at the superficial layers of the neuroepithelium and the ependymal layers surrounding the fourth and lateral ventricles and in neurons of the dorsal root ganglia and in dorsal roots between the cartilage primordia as well as in cranial sensory ganglia (PubMed:20563991). Also expressed along the apical epidermal ridge and in the forelimb and hind limb (PubMed:20563991)
+Present in both promastigotes and amastigotes
+Expressed in spermatogenic cells during early spermatogenesis. Expression increases in intermediate spermatogonia through to zygotene spermatocytes but becomes diminished in the steps from early pachytene spermatocytes through to round spermatids. After meiosis, expression reappears in spermatids and is present in elongating spermatids until spermiation. Not detected in Sertoli cells
+Strongly induced at heart stage of embryogenesis
+Strongly expressed in embryos. Also found in late larval and pupal stages
+Expressed in the fetal heart
+Found at all stages of developing glomeruli and the presumptive proximal tubules in the embryonic kidney. The expression was restricted to the presumptive podocyte
+Expressed in the otic vesicle, urogenital bud and dorsal root ganglia at 10.5 dpc, in the neural tube and neural crest cell derivatives of the peripheral nervous system at 11.5 dpc
+Expression is first detected at embryonic day 13
+Highly expressed during the first two days post-germinative growth. Strongly up-regulated in senescence
+Present in high amounts in hemolymph only at the end of larval life
+Expressed in adult
+No expression found in embryos
+Expressed in a ring surrounding the center of meristems extended in the cortex of developing stems and older pedicels. Present in all developing floral organs, especially in anthers and gynoecium. Observed in anthers at stage 2 in the archesporial cells. At stage 3, localized in the primary sporogenous and primary parietal cells. Subsequently preferentially expressed in the sporogenous cells at anther stage 4. Later restricted to the tapetum and pollen mother cells (PMCs) before disappearing progressively
+Abundantly expressed during spermatogenesis. Not detected in newborn animals, in which spermatogenesis has not yet progressed beyond the earliest stages
+Levels in leaves diminishes after transition from the vegetative to the reproductive phase. Accumulates strongly in developmental tissues (PubMed:21395597). Highly expressed in the male (e.g. pollen grains and pollen tubes) and female (e.g. synergids, egg cell and central cell) gametophytes before and during, but not after fertilization. In fertilized ovules, levels decrease rapidely to become undetectable at the stage before the first division of the endosperm (PubMed:21123745)
+Beta isoform is expressed during embryogenesis, most abundant in midembryogenesis, and in adults. Alpha isoform is expressed from embryogenesis to 8 hours after pupariation, major period of expression is during second instar
+Expressed in embryonic shoot apical meristems, in inflorescence and floral meristems, and in developing stamens, carpels and ovules. Also expressed in vegetative meristems and leaf primordia
+Higher expression in neonates than in adult
+During preimplantation development expressed through all stages from oocyte to blastocyst. High expression is detected in oocyte that declines to a stable level from the 8-cell stage until 8.5 dpc. Expressed in the blastocyst in both the inner cell mass and the trophectoderm
+Isoform HK1-SA: First expressed during meiosis and continues to be present in postmeiotic germ cells (PubMed:8396993, PubMed:9450953). Isoform HK1-SB: Present only in postmeiotic germ cells (PubMed:8396993)
+Expressed ubiquitously in the embryos. Strongly expressed at the midbrain and hindbrain boundary at 2 days post-fertilization (dpf)
+Expressed at low levels in MII oocytes and 1-cell embryos and increases through subsequent cleavage stage divisions. The peak of mRNA expression occurs at the morula stage, with a slight decrease in blastocyst embryos
+Expressed in early embryonic stages
+Expressed in fetal and pediatric kidney cells
+At 10 dpc expressed in a wide variety of tissues with relatively more abundant expression in limb buds (PubMed:18848646). At 10.5-12.5 dpc, detected in vessels of the developing CNS and perineural vascular plexus (PNVP) (PubMed:21282641). Expressed in both endothelial cells and pericytes, most prominently in brain and neural tube, and to a lesser degrees in non-CNS embryonic organs, including the liver, heart, and kidney (PubMed:18848646, PubMed:21282641). Expressed also in embryonic epithelium of lung and esophagus and in mesenchyme (PubMed:18848646, PubMed:21282641). Detected in mesenchyme of the palatal shelf at 12.5 dpc (PubMed:21282641)
+Specifically expressed in ameloblasts during maturation stages. Not expressed in pre-ameloblasts, weakly expressed in secretory ameloblasts, and strongly expressed in maturation-stage ameloblasts as well as in the junctional epithelium attached to the enamel of erupted molars
+Levels are highest on day 0 of penultimate instar larvae and then decrease throughout larval growth with a temporary increase on day 0 of the last larval instar. In parasitized larvae, expression increases within one day of parasitization with elevated levels persisting for one day, declining gradually, rising and then declining again
+Expression levels are high in surface mucous cells and manicotto gland cells of the foregut epithelium of pro-metamorphic tadpoles. During metamorphosis, expression levels decrease markedly in larval epithelial cells but are high in proliferating adult epithelial primordia. In the adult stomach, expression was strongest in oxynticopeptic cells, but was also detected at a lower level in surface mucose cells
+Expression in the brain is strongest at day 12 dpc, particularly in the cortical ventricular zone. In the cortex of newborn mice (P0), RAD51 is mainly present in the subplate and, in lesser amounts, in layer V. It is detected in a subpopulation of corticospinal axons at the pyramidal decussation in 2-day-old (P2) mice
+During male tail development, expressed in each of the nine Rn cells and in the anterior daughter cell, the ray neuroblast (at protein level) (PubMed:11076762). First expressed at the comma stage of embryogenesis (PubMed:19632181). Expressed asymmetrically, in the mother cell of the MI pharyngeal motorneuron but not in the mother cell of the e3D epithelial cell (PubMed:21041366). Expressed during hermaphrodite gonadogenesis, in the two somatic gonadal progenitor (SGP) cells, Z1.ppp and Z4.aaa, precursors to the anchor cell (AC) and the ventral uterine precursor cell (VU), but not detected in their sister cells, Z1.ppa and Z4.aap (PubMed:14701877, PubMed:19376107, PubMed:21784067). Expressed in both pre-AC and pre-VU cells, and after the AC/VU decision, expression is reduced in the VU and its descendants; however, expression persists in the AC through the time of basement membrane invasion (PubMed:21784067, PubMed:31402303). Expressed in the gonadal distal tip cells (DTCs) throughout development and in adults (PubMed:19376107)
+Present in oocytes and at every embryonic stage (at protein level)
+Expressed in embryos, larvae and adults (at protein level) (PubMed:18562695, PubMed:31626769). Expressed in embryonal and larval neuroblasts (at protein level) (PubMed:18562695). Expressed during oogenesis (at protein level) (PubMed:31626769)
+Expression is continuous throughout the developmental period, but is highest during the feeding period in the early half of the fifth instar stage (days 0-4). Expression decreases remarkably on day 5 before larvae start wandering on day 6, but stabilizes before the end of the fifth instar stage
+Detected in brain from 14 dpc until adulthood with higher expression between 18 dpc and P7 (at protein level)
+At 7 and 8 weeks of development, it is highly abundant in the rapidly dividing cells of the central and peripheral nervous systems, the mesenchyme of the frontonasal and mandibular processes and the dermamyotome, and it is expressed in the endodermal derivatives of the foregut, midgut, and hindgut, as well as in the liver, lung, esophagus, and trachea. During midterm fetal stages, 18 and 23 weeks of development, increased expression is observed in the intestinal crypts. Midterm liver and kidney tissues strongly express CLMP in the parenchyma of the lobules and cortex, respectively
+Isoform 4, isoform 7, isoform 18, isoform 19, isoform 24, isoform 25 and isoform 31 are adult-specific. Isoform 8, isoform 14, isoform 15, isoform 16, isoform 17, isoform 20, isoform 21, isoform 22, isoform 23, isoform 26, isoform 27, isoform 28, isoform 29 and isoform 30 are fetal-specific. Isoform 1, isoform 2, isoform 6, isoform 9, isoform 11, isoform 12 and isoform 13 are expressed in both fetus and adult
+Larvae and adult
+Expression started in the intermediate zone of spinal motor neurons as they differentiate into postmitotic motor neurons
+It is present in young cotyledons at 14 days after fertilization (daf) when cells are still rapidly dividing. Levels steadily accumulate until the end of the cell expansion phase (35-40 daf) and with the beginning of the seeds desiccation phase at 50 daf, the levels decrease to very low levels
+Weakly expressed at 30 hours post fertilization (hpf) in the ventral head mesenchyme, but not spatially restricted after this time-point
+Expressed in neurons and muscle throughout development
+First detected in the posterior tail bud at around 16.5 hours post-fertilization (hpf), expression continuing through to 36 hpf. Expressed in the developing fin fold and neural tube from 48-72 hpf
+Expressed early in development (15 dpc), and gradually increases, reaching a peak at around 2 weeks after birth
+At 10.5 dpc, strongly expressed in the neural progenitor cells throughout the neural tube and in the myotome. Expression is significantly lower in connective tissues compared to neural tube, but can be detected at the mitotic spindles of dividing mesenchymal cells loosely distributed in the developing limb bud. In an 12.5 dpc forelimb bud, detected in the dividing cells at the boundary region between protruding cartilage and surrounding mesenchyme (at protein level)
+Expressed in an organ specific manner through mid- to late embryonic development with persistent high-level expression in brown adipose tissue and intestinal mucosa
+The statin expression is specific for nonproliferating cells. Its message is most abundant in G0 phase of 3T3 mouse fibroblasts, but becomes significantly reduced in G1 and S1 phases cells
+Detected in brain cortex at 15.5 dpc. Highly expressed in brain cortex from young and adult animals (at protein level)
+Mostly expressed in seedlings, and, to a lower extent, in leaves and flowers
+Expressed in almost all blastocysts at 3.0 dpc. Preferentially expressed in the trophectoderm (TE) in 3.5 dpc and polar TE in 4.0 dpc blastocysts. In 4.5 dpc embryos, expressed in the polar TE and some inner cell mass (ICM) embryonic lineage cells. In post-implantation embryo at 5.5 dpc, expressed in the epiblast (embryonic lineage) derived from the ICM. Highly expressed, at 7.5 dpc, in the embryonic ectoderm, neural ectoderm, and chorionic ectoderm; a weak expression is also detected in mesodermal and endodermal cells. At later stages, the expression is detected predominantly in the forebrain and eyes but weakly throughout the embryo
+Detected from late meiosis and accumulates during early spermiogenesis
+Expressed at high levels in actively dividing cells, during all stages of development
+Expressed primarily at the mound stage
+Highly expressed in presecretory ameloblasts with very high expression in secretory ameloblasts. Expression decreases in the maturation stage and is very low in the late maturation stage
+Expressed at 7 dpc, higher expression observed in stages 15 dpc and 18 dpc
+Expressed in fetal lung, kidney, liver, and brain
+First detected in the cranial ganglions and the dorsal part of the central nervous system on 9.5 dpc (PubMed:7721778). From 10.5 dpc onward, prominently expressed in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by 18 dpc and is undetectable in the adult nervous system (PubMed:7721778). Expressed in the cochlear nucleus at 15.5 dpc (PubMed:17977745)
+At 9.5 dpc ubiquitously expressed at low levels with slightly elevated levels in the pharyngeal arches and in the forelimb buds. At 10.5 dpc expression was more pronounced in the first and second pharyngeal arches, the nasal processes and the limb buds. At 11.5 dpc expression is high in frontonasal region, maxillary and mandibular processes of the first and second pharyngeal arch and developing fore and hindlimbs. From 11.5 dpc-12.5 dpc expression is seen in the distal parts of the developing limbs and in the facial region. At 12.5 dpc transcripts were found in the developing hair follicles of the vibrissae
+Expressed during early rosette development and during flowering
+Potentially subject to developmental regulation
+Expressed at peak level in day 12 embryos (PubMed:2574853). Isoform 1: Maternally contributed and highly expressed at the zygotic stage, with rapidly decreasing expression at the two cell stage remaining consistently low through to morula stage (PubMed:20624068)
+First expressed in late larvae (stages 62-64). Also expressed in adults
+Expressed maternally. At end of gastrulation, expressed in the prospective neural plate region. In neurula stages, shows highest expression in the sensorial layer of the neurectoderm, decreasing from anterior to posterior. Shows localized expression within the anterior neural plate, including the floor of the neural groove. Expressed in the cement gland anlage at stage 14. At stage 16, expressed in the neural groove, rhombomeres, forebrain and branchial arches. At stage 22, abundant in the eye vesicles, ear placodes, prospective branchial arches, pronephric anlage, prospective pronephric duct, presomitic mesoderm and the somites. In the developing brain, expression is dynamic, being most abundant in the mesencephalon and posterior rhombencephalon. At stage 30, expressed in cephalic ganglia V and VII and in stage 35, also IX and X. Also expressed in the future endocardium and pericardium. At stage 32, expressed in the neural groove, rhombomeres, forebrain and branchial arches. At stage 35, expressed in the future choroid plexus of the telencephalon and in the ependymal layer. Throughout the neural tube, expressed in a dorsal to ventral gradient. In the developing eye, expressed in the prospective ganglion cell layer, the ciliary marginal zone and the lens
+Expressed from before hatching of first instar larvae (at protein level)
+In seeds, observed mainly in the endosperm and the embryo (PubMed:18687588). In seedlings, detected in vascular tissues and hydathodes of cotyledons (PubMed:18687588). Later expressed in trichomes of rosette leaves (PubMed:18687588). In flowers, accumulates in the receptacles, in vascular tissues of sepals and petals, in the style and stigma of the carpels, and in anthers, filaments, and pollen (PubMed:18687588). Also present in siliques funiculi (PubMed:18687588)
+Expressed in the most anterior part of the prospective neural plate along the rostral-caudal axis. At the tail bud stage, expressed in the prospective forebrain region. From 15-somite to 24 hours post-fertilization (hpf), expression is mostly confined to the telencephalon and the anterior-ventral region of diencephalon Expression is restricted to ectoderm at 80% epiboly stage. From 15-somite to 24 hpf, expression is mostly confined to the telencephalon and the anterior-ventral region of diencephalon
+Expression is first detected at postnatal day 21
+Expressed in root and shoot meristems and also in young still meristematic leaf and flower primordia (PubMed:18359753). In seedlings, accumulates ubiquitously at low levels. Expressed in shoot apical meristem (SAM), primary leaves, apex of cotyledons, and at the hypocotyl-root transition. In roots, present at the origin of lateral roots and the root tip, as well as in the vascular tissue of lateral roots (PubMed:17419845)
+Expressed in embryos and larvae (PubMed:11557844, PubMed:15707894). Expressed in the distal zone of mitotic germline and in late pachytene, diplotene and diakinesis stages of meiotic germline (PubMed:11557844, PubMed:15707894, PubMed:21901106)
+Expressed in early stage of myeloid and erythroid differentiation
+Abundant in the liver but not in non-hematopoietic tissues of 13 dpc embryos
+Continuous increase of expression in developing cotyledons until day 20
+Expression in the met-mesencephalic region
+At stage 15, faint expression in the antero-ventral mesoderm. By stage 20, after neural tube closure, expressed in the ventro-lateral mesoderm of the mid-embryo with punctate expression in the anterior clusters of subepidermal cells, which may represent migrating neural crest cells. By stage 24 (early tailbud stage), the expression pattern expands to include lateral plate mesoderm in the mid-embryo, symmetrically along the left-right axis, and the heart anlage in the ventral midline. By stages 28-30 (late tailbud stages), the region of expression in the lateral plate mesoderm has expanded into a symmetrical arc of ventral and lateral expression, which fuses in the midline where the straight heart tube has formed. At the same stages, branchial arches present high levels of expression. By stage 33 (beginning of heart looping), expressed in the heart, lateral mesoderm and branchial arches. The expression persists in the looped heart and the branchial arches throughout stage 37. Most abundant in the heart and outflow tract at stage 47 (tadpole stage)
+Detected in the otic placode and the pineal gland in embryos 24 hours after fertilization. Detected in the sensory hair epithelium along the entire length of the lateral line organ in larvae 72 hours post fertilization. Restricted mainly to neuroepithelial patches in the ear of larvae 72 hours post fertilization
+Expressed in the somites and dorsa from 9.5 dpc and in the yolk sac and embryonic vasculature from 10.5 dpc. Expression within the large and small blood vessels increases at 11.5 dpc and 13.5 dpc, with high expression in the vascular smooth muscle at 16.5 dpc. Also expressed later in development in mesenchymal cells in the dermal layer, the developing skeleton, connective tissue and the umbilical ring and vessels. Up-regulated during vascular smooth muscle cell differentiation and down-regulated during adipocyte differentiation and osteoblast differentiation
+Detected in 13-day old embryos. Expression increases gradually in later embryos and markedly in neonates to adults
+Present in vegetative cells; the levels decrease slightly upon starvation and remain constant until 10 hours of development and then decline. At 25 hours there is very little detectable protein
+Expressed at the youngest stages of ovule development, predominantly to the adaxial side of the ovule primordium. Later, expression becomes restricted to a region in the distal chalaza. When the integuments initiate, expressed in the inner integument, with highest expression in the inner layer of the inner integument. Expressed in the vegetative shoot apical meristem (SAM) and initially throughout the presumptive cotyledons. At the globular stage, just before cotyledon outgrowth, expressed at high levels in cotyledon adaxial domains. Expression is lost from the SAM of torpedo stage embryos but is regained late in embryogenesis, extending to young primordia after germination, and becoming progressively restricted to the adaxial domain and the vasculature. Preferentially expressed in the adaxial domain of the developing leaf. Expressed throughout the plastochron 0 (P0) leaf primordium and expression increases in P1 to become preferentially localized to the adaxial leaf domain by the P2 stage (polar expression)
+Transcript levels diminished during rosette leaves development
+Expressed in the retina 3 days post-fertilization (hpf)
+Already expressed by 11 dpc, maximally around birth, expression decreasing gradually during the second postnatal week, with no expression in adult stages
+Expressed throughout embryonic development and in adults (PubMed:22768349). During embryogenesis, expressed from the 2-cell stage and persists throughout development in transcriptionally active cells (PubMed:22768349). Expression is higher in dauer larvae than in adults (PubMed:11743719)
+At 6 weeks post-conception (WPC) expressed in the hyaloid artery and lens capsule (at protein level) (PubMed:29777959). Expressed between 6 and 19 WPC in the choroid and Bruch's membrane with faint expression in the retinal pigment epithelium, outer neuroblastic zone, inner plexiform layer, and the inner neuroblastic zone (at protein level) (PubMed:29777959)
+Detected from 7 to 17 dpc. Overall expression clearly diminishes after 13 dpc. Mostly expressed in mesoderm-derived tissues, but also present in some neurectoderm-derived sites. High expression limited to mesenchymal tissues. In 11.5 and 13.5 dpc lungs, mostly restricted to the peribronchial mesenchymal cells. In the aorta and other major blood vessels, found in the subendothelial smooth muscle cell layers. Also expressed in the outflow tract of the heart ventricle, but not in other parts of the heart. At 13.5 dpc, in the developing kidney, detected in the metanephric cap mesenchyme of the cortical region, in the condensing mesenchyme surrounding the ureteric branches. Not detected in the adrenal glands. At 11.5 and 13.5 dpc, expressed weakly in the liver septae, but not in the parenchyme. Very strong expression in both the stomach and intestine, in the submucosal layers, in the condensing splanchnic mesenchyme. At 13.5 dpc, expressed in the mesenchymal cells of pancreas, gonad, mesonephric tissue and genital eminence. At 13.5 dpc, expressed in the thymus. At 11.5 dpc, strong expression in the mesenchyme of the mandibular process, with highest expression in the mesenchymal cell layer just below the oral epithelium. Not detected in the overlying epithelium. At 13.5 dpc, highly expressed in the dental mesenchyme surrounding the epithelial bud and near the top of the lip furrow, as well as in the tongue. At 13.5 dpc, expressed in the cartilage primordia of the ear and snout. Highly expressed in intervertebral disks, but not detected in the notochord and vertebrae, both at 11.5 and 13.5 dpc. Highly expressed in mesenchymal condensations of both the forelimb and hindlimb. Overall low expression in the nervous system. At 11.5 dpc, low expression in the neuroepithelium of the hindbrain, the telencephalic vesicle and neuro-epithelial cells lining the mesencephalic vesicle. At 13.5 dpc, detected in the roof of the neopallial cortex, which gives rise to the future cerebral cortex. Weak expression also observed in the medulla oblongata, the choroid plexus, and the ventral mantle layer of the spinal cord. Stronger expression in the ganglia of the glossopharyngeal nerve. At 11.5 and 13.5 dpc, expressed in the mesenchyme surrounding the olfactory epithelium, but not in the epithelium itself. Similarly expressed in the mesenchymal tissues lining the dorsal root ganglia (perineurium), but not in the ganglia. Expression also observed in a few epithelial cells (ectodermal origin), including, at 11.5 dpc, the ventromedial wall of the otic vesicle and, at 13.5 dpc, the cochlea of the inner ear. In the eye, expressed not only in the neural retina but also the cells that compose the wall of the lens vesicle
+Expressed in flowers during the whole flower development
+Strongly expressed in the eye, branchial arches and telencephalon of stage 26-33 embryos
+Expressed during adipocyte differentiation. Expression appears 2 days following induction of adipose conversion, reaching a peak after 6 days
+It is detected throughout embryogenesis until expression declines in mature embryo. During embryogenesis it is detected in patches of single cells or small cell groups
+Detected early after fertilization in the zygotic embryo and free endosperm nuclei. Expression continues in the embryo at the heart and torpedo stages, but is restricted to the chalazal nuclei in endosperm before cellularization. At maturity, expressed mainly in the embryo epidermis and in the vascular tissue
+Expressed in gonadal somatic pre-Sertoli cells from 10.5 to 11.5 dpc. Expressed in pre-Sertoli cells located centrally in the genital ridge and then later in cells located at the cranial and caudal poles (at protein level)
+Expressed in all stages of development including spores
+First detected in the embryonic ectoderm at early stage 11, but this expression is transient. Zygotic expression is first detected in stage 12 embryos and cytoplasmic expression is detected in many cells around stage 14. Embryonic cells maintain expression throughout their lifetime and expression continues into hatchling larvae less than 24 hours old
+Both maternally and zygotically expressed. Expressed at all stages of early development. Expressed from 8-cell stage to 48 hours post-fertilization (hpf). Expressed in the eyes at 48 hpf
+During embryogenesis, expressed in a complex spatial and temporal pattern in various embryonic epithelia. In 7.5 and 13.5 day old embryo, expressed in most endodermal epithelia, ectodermal and nascent mesodermal tissues. When the neural plate forms, expression begins in the cells of skin ectoderm, head process/notochord, periderm, whisker buds, choroid plexus and the epithelia of auditory duct and inner ear. High expression in the lining endodermal cells when the foregut and hindgut invaginations form. Expression in all three layers of the urothelium starts at day 15 in the embryo and is not visible after day 18. By day 11 and 12, the entire embryonic palatal epithelium shows expression as well as the nasal passages and the roof of the mouth; which disappears progresively from day 13 to 15
+Expressed starting 2 hours after sporulation onset for at least 7 hours
+Expressed during female gametophyte development
+Expressed in early embryonic stages of epiphysis development from 9.5 dpc onwards
+Expression is restricted to the developing heart at the stage of 9.5 dpc, and increases after 11.5 dpc as development of tissues and organs proceeds. Present in many developing tissues including heart, brain, lung, liver, gut, kidney, skeletal muscle, cartilage and epidermis (at protein level)
+In all brain areas, expression levels are high during embryonic development and decrease postanatally
+Expressed in globular stage embryo 3 days after pollination (DAP) in a small region just below the center of the ventral portion of the embryo. At coleoptile stages, mainly expressed in the basal and central parts of the ventral side of the embryo, in cells just below the coleoptile, and corresponding to the epiblast and part of the shoot region. At the shoot apex differentiation stage, expressed in the shoot apical meristem (SAM) and the epiblast, but not in the region between the SAM and epiblast. Expressed also in the cells surrounding the ventral side of the root apical meristem. Expression pattern is maintained in subsequent stages after the second leaf primordium is formed. During inflorescence development, expressed only in the corpus of the rachis primordium, but not in the tunica layer (L1). After floral induction, expressed in both tunica and corpus, but not in floral organ primordia. Later in flower development, expression in the corpus of the floral meristem disappears
+Expressed in the early stages of infection
+Expressed in the shoot meristem and root epidermal cells in germinating seeds. At the reproductive stage, expressed in the whole shoot apex
+Is not expressed in neural cells at stages before neural tube closure. Is expressed at high levels in the dorsal third of the neural tube, beginning at the time of neural tube closure, but not by ventral neural cells or by nonneural cells. Dorsal restriction persists in the spinal cord at stages after the onset of neuronal differentiation. At later stages of spinal development, is restricted to the dorsomedial region of the spinal cord, including but not confined to the roof plate
+Expressed almost at the same level throughout the life cycle. Expressed in PstA, PstB and PstO prestalk cells in the developmental phase and not in the prespore cells
+Present in all the different life cycle stages
+Expressed during S phase. Expression increases as cell moves from S phase to M phase and then decreases rapidly as cell enters the G1 phase. Expression increases again during the G2 phase
+During development of the retina, expression is highest in the inner, neuroblastic layer, while at later stages it is also present in the photoreceptor cell layer. Detected in the eye from 14.5 dpc onwards. Highly expressed in the liver and primitive gut, and at lower levels in the umbilical vein, the ventricular layer of the CNS and upper/lower jaw region. At 14.5 dpc and 16.5 dpc, expression in the liver and stomach is maintained. In addition, expression is present in bone structures (e.g. zygomatic bone, lower jawbone), cranial nerve ganglia [e.g. trigeminal (V) ganglion] and cochlea. The expression in the eye is seen in the neuroblastic layer. At 16.5 dpc and 18.5 dpc, a slightly higher expression is seen in the neuroblastic layer. At 16.5 dpc, strong expression in the upper part of the gut is maintained and with the onset of ossification, expression is seen in all bone structures of the body. At P7 and P90, expression in the eye is seen in the ganglion cell layer, the inner nuclear layer (INL) and photoreceptor cell layer
+Expressed in vegetative cells and throughout development with a peak during the mound stage of morphogenesis
+Low levels detected in testes at day 7 postnatally, with 10-fold increased levels detected by day 28, remaining into adulthood
+Expressed during the late capillary loop stage of glomerulogenesis. First detected in junctional complexes in podocytes after their migration to the base of cells. Up-regulated upon foot process differentiation
+Expression in the yolk sac tissues followed by expression in the primordial liver cell nests as early as day 9 post-coitum (9.5 dpc). Intestinal expression is detected around 12.5 dpc and attains full adult expression patterns by 14.5 dpc
+Expressed in the soma during early embryogenesis, and widely expressed after hatching. Isoform C: Expressed in the soma during early embryogenesis, but after hatching, expression in larvae is restricted to V and P lineages, the postembryonic lineages that contribute to the seam cells and vulval precursor cells, respectively
+Expression is first detected in embryonic retina at 15 dpc and increases with developmental age
+Isoform 3 expression in adult testis is 14.2-fold stronger than in embryonic testis
+Expressed during pollen development and megasporogenesis in the nucellus of developing ovules, in all cells of the embryo sac up to fertilization and in all cells of the developing embryo until the heart-shaped stage. Found in epidermal and vascular cells of the late torpedo and cotyledon stages embryos
+Expressed from 17.5 hours of development of the fruiting bodies
+In brain, expression is lower in the adult than in the neonate
+Expression decreased with development in ventricular tissue while remaining highly expressed in adult atrial tissue. In primary cultures of human skeletal myocytes, expression decreased during myogenic differentiation (at protein level)
+Expressed in a restricted set of neurons, and epithelial cells of the uterus and the excretory system, late in embryogenesis at about 300 minutes of development (PubMed:10068647). Expression in neurons continues throughout adulthood (PubMed:10068647). Expressed asymmetrically, only in the left neuron (ASEL), of the ASER and ASEL chemosensory pair (PubMed:10068647). Expressed in the interneuron PVT during embryogenesis (PubMed:12490565)
+Isoform 3/MAP2c is expressed during embryonic brain development and until postanatal day 10. Isoform 2 is expressed throughout brain development
+In embryos, expressed at low levels in a restricted area of the brain that includes the subpallium
+Maximum levels are found during anthesis
+Detected in embryos from 7 dpc to 17 dpc. Weakly expressed in heart at 9.5 dpc. Expression is detected in endothelial cells of the dorsal aorta at 10.5 dpc and disappear at 12.5 dpc. Expression in smooth muscle cells is first detected at 11.5 dpc. Strongly expressed in vitelline vessels at 12.5 dpc. Expressed in all smooth muscle cells at 16.5 dpc
+Expressed at the breaker stage during fruit ripening
+Transiently expressed before and during menstrual bleeding
+First detected at 12.5 dpc in a small number of pancreas epithelial cells. Highly expressed in embryonic pancreas epithelium at later stages of embryonic development
+Expressed from the 8-cell stage and subsequently throughout embryogenesis. After hatching, highly expressed in neurons including nerve ring cells, neurons in the tail and DD/VD motor neurons in the ventral nerve cord. Also expressed in body wall muscle and pharyngeal muscle
+First expressed in hypodermal, seam, and P cells at the 3-fold stage during embryogenesis (at protein level) (PubMed:33872306). During late embryogenesis, expressed in hypodermal and P neural progenitor cells (at protein level) (PubMed:33872306). At the late L1 larval stage, expressed in the descendants of P cells, rectal epithelial F, K, and U cells and seam cells (at protein level) (PubMed:33872306)
+Expressed in the hemisphere. Highly expressed in ciliated tissues. At stage 12 (late gastrula), detected in the dorsal involuting marginal zone. Expressed in the gastrocoel roof plate (GRP) at stage 16 (neurula stage;). At stage 25 (early tailbud stage) and stage 33/34 (late tailbud stage), expressed in the floor plate, cloaca and ear vesicle. At stage 33/34 (late tailbud stage), detected in nephrostomes. Expressed in the epidermis at stage 13 and thereafter. Specifically expressed in multiciliated cells (MCCs) on the epidermis
+First detected in developing pancreatic duct at 3 dpf (PubMed:25592226). Detected on Kupffer's vesicle during embryonic development (PubMed:23487313, PubMed:26432887). Detected on neural floorplate, brain and pronephric duct primordia in embryos at the 10 somite stage (PubMed:26432887)
+In endosperm, accumulates during early developmental stages and declines near maturity. In embryos, levels peak at middevelopment with highest expression in the embryonic axis. Also present in young pericarp and immature ear tip and base
+Expression increases during flower development
+Expressed throughout development. Highest expression is observed in pupae (at protein level). During oogenesis, expressed from stage 10B onwards
+Expressed zygotically in both embryos and adults. Embryonic expression initiates during gastrulation, is down-regulated between stages 15 and 23, and is then elevated up to stage 41
+Predominantly expressed in the embryonic and early postnatal stages. Little or no detection in adult brain
+Expression first detected around the onset of spicule formation and rapidly increased with the growth of spicules
+Ubiquitously expressed during embryogenesis. Expression starts in some seminiferous tubules at 2 weeks of age. After mid-puberty a stage-specific expression is established. During the cycling of the seminiferous epithelium, expression initiates in the pachytene spermatocytes of stage V seminiferous tubules, peaks at stage X, then decreases as pachytene spermatocytes differentiate into secondary spermatocytes and then round spermatids
+First detectable at early gastrula stages. Expressed in the anterior-most region of the open neural plate and midanterior and midlateral anterior ridge. By late neurula stages, expressed in the derivatives of these regions namely, in the anterior and rostral ventrolateral part of the forebrain neuroepithelium, primordium striatum, optic stalk, chiasmatic ridge and the anterior hypothalamus. At tailbud stages the expression extends laterally and caudally with the enlargement of the forebrain ventricle. Expression in the tadpole stage embryos is specific to the optic disk, optic stalk and anterior hypothalamus
+Expressed throughout embryonic, larval and adult development. Not maternally expressed
+Predominantly expressed in the vascular bundle of the primary root and in the cortex of the root upper part. In lateral roots, detected in epidermis and root tips
+Expressed in embryo and larva with a sharp decline by the late third instar larval stage. Expression peaks 6 hours after puparium formation, drops and remains low until the second day of pupal development and then grows steadily during adult morphogenesis
+Expressed during embryogenesis (at protein level) (PubMed:20026024). First expressed shortly after the assembly of the gonad primordium (PubMed:15294864). Expressed in somatic gonadal precursor (SGP) cells in embryos and L1 stage larvae (PubMed:20026024, PubMed:24402584). Expressed in daughter cells of SGP cells throughout the L1 larval stage (PubMed:20026024)
+Expressed in various fetal tissues
+In the brain, expression starts at P6 and increases to reach a plateau at P20
+At stage 12, expressed throughout the invaginating optic vesicles and a subset of cells in the ventral spinal cord, presumably interneuron precursors. At stage 14, when the optic cup forms, expression is restricted to a subset of retinoblasts. At stage 15, expression along the ventral spinal and hindbrain intensifies and persists beyond stage 20
+Larval stages
+Not expressed in the oocyte
+Expressed in the oocyte from 9.5 dpc to 14.5 dpc
+Expression increases steadily throughout oocyte maturation
+Expression decreases in the egg as compared to the oocyte
+Expressed in oocytes throughout oogenesis. Undetectable in eggs and during early embryonic stages up to the tailbud stage (at protein level). Expressed during early embryonic stages beyond stage 8 (mid-blastula transition; MBT)
+Largest accumulation of transcripts is seen in the posterior 16 midbody segments of the leech embryo between days 7 and 14
+Expressed in the cortical plate, subplate, and intermediate zone of the mid-gestation fetal cortex
+At Carnagie stage 13 (CS13, after 4 weeks of development) and CS14 CC2D2A is ubiquitously expressed, with a distinct signal in the spinal cord and limb buds. At CS17 CC2D2A continue to be widely expressedin particular throughout the central nervous system (CNS), lung, and digestive tract epithelia. At CS22 expression continues to be intense within the CNS, where strong and specific expression is observed in the eye and in external granular layer of cerebellum. CC2D2A expression is also observed in the costal perichondrium
+Expressed both maternally and zygotically. Present throughout embryogenesis and larval stages
+Absent from the primary root (PubMed:23370719). Expressed irregularly throughout the cotyledon and accumulates at the base of the organ (PubMed:23370719). In leaves, present at a high level in the basal part, close to the main veins, irregularly in the lamina joining these veins, and in separate segments of the leaf margin (PubMed:23370719). Observed in the stem, the rachis of the inflorescence, and the lower portion of the flower pedicel, especially at its upper side (PubMed:23370719). In flowers, detected throughout its development at the base of the sepals, in the petals, the filament of the stamens and the gynoecium, and later in siliques (PubMed:23370719). During seedling gravitropic response, restricted to the epidermis and cortex and enhanced at the lower side of the reoriented hypocotyl (PubMed:22421050)
+Present in all somatic cells from the 50- to 80-cell stage on throughout development and in adult animals
+Expressed in male gametocytes (at protein level) (PubMed:21790945). Expressed in ookinetes and oocysts (at protein level) (PubMed:24471657)
+Regulated expression during B-cell differentiation. Low expression in pro-B cells, pre-B I cells and large pre-B II cells. Levels peak in small pre-B II and then slightly decrease in immature B-cells. Low levels in CD34+ umbilical cord blood cells
+Expressed (in low abundance) during the first half of the developmental cycle
+At 12.5 dpc and 13.5 dpc, expressed in the central and peripheral nervous system and in endothelia. In the nervous system, expression localized to the ventral portion of the neural tube and the dorsal root and cranial sensory ganglia. Expression confined to neurons
+Only starts to be expressed in late oogenesis (stage IV) and is relatively abundant in eggs and embryos, peaking at embryonic stages 12-20, corresponding to gastrula and neural fold stages. At stage 42, which corresponds to the tadpole-like stage, present in neuron-rich tissues such as eye and brain (at protein level)
+Expressed in the developing wing bud. At stage 31, widely expressed with a higher level in limb and head
+Detected in embryo at high levels on day 7, whereas expression decreases at day 11 and increases from day 15 to 17. On day 15 found in developing bone primordia, brachiocephalic artery and ductus arteriosus, left main bronchus, abdominal aorta and midgut
+Very low expression in eggs. Expression increases during the first and second instar larval stages, decreases in the third instar larval stage and increases again in pupae and adults
+Expressed throughout embryogenesis (at protein level) (PubMed:18635357). First expressed at the two-cell stage of embryogenesis (at protein level) (PubMed:18635357)
+Present in flowers, particularly in petals, stamens and anthers (including pollen). Slightly expressed in developing ovaries, strongly expressed in developing embryos and in siliques outer integuments (mostly in base and tips). During first days after germination, mainly localized in roots, including root tips. Later, ubiquitous except in root tips
+First detected at 12.5 dpc in cartilage primordium, it is present in the osseous matrix of developing limbs, vertebrae, ribs and skull. At 16.5 dpc it is detected in bone matrix and smooth muscle, and at lower levels in connective tissue, bronchial epithelial cells, metanephron microtubules, and skin
+Expressed in egg, larva, pupa and adult. In fifth-instar larvae stage, highly expressed in the nerve cord, and by a lesser extent in the epidermis, hemocytes, Malpighian tubules, midgut and fat body
+Expressed during embryonic brain development and the highest levels are observed postnatally
+During ovule development, expressed in the nucellus from early stage until embryo sac maturity
+First expressed in body wall muscles and hypodermal cells during embryonic development to adulthood. Expressed in the pharynx and hypodermis from larval stages L1 to L3. Expressed in hermaphrodite-specific neurons from the L4 stage of larval development
+Expressed in the limb mesenchyme throughout stages 16 to 32. Expressed in the prospective wing bud at stage 16. Expressed in the leg bud at stage 17. Expressed in the forebrain throughout stages 14 to 21
+Expression in 24-36 hours post-fertilization (hpf) embryos shows a clear segmental pattern. By 48 hpf, when segmental angiogenesis is completed, is no longer expressed in somites
+Expressed from neurula stage onwards
+Transcripts accumulate in mature pollen before and during germination, but translation starts only when pollen germination initiates, and continues in pollen tubes. Expressed in cells surrounding the vascular bundle of the anther connective tissue, mostly at the dehiscence time. Also present in a ring of parenchymatic cells between the xylem vessels of the style (upper end of the transmitting tract toward which pollen tubes grow). Expressed in the epidermal cell layers of funiculi (at protein level)
+Expressed throughout embryonic and larval development with peaks of expression during mid-embryogenesis and at third larval instar (at protein level). The relative ratio of isoform 1/PS2C and isoform 2/PS2M8 varies widely during development
+In flowers, mostly present in developing and mature male gametophytes and in the endosperm
+Expression starts at 19 dpc in brain
+First expressed in the embryo proliferation stage, increases during early somatic embryo development and decreases thereafter
+Most abundant during the mid stage of flower bud development but not detected in leaf tissues
+Expressed in ripening seeds during testa formation and desiccation
+Expressed during gastrulation, and shortly after gastrulation is expressed by presumptive precursor cells of the olfactory placodes, overlapping subsets of cells in the auditory vesicle, cells of the median fin fold, and cells of the visceral arches and their primordia
+The levels peak in the G1 phase of the cell cycle, then mostly disappear during S phase and reappear in the G2 phase
+Expression was first detected at 11 dpc throughout the surface of the embryo, and it was most intense in the head region on the surfaces of the mandibular, maxillary, and frontonasal processes. At 11.5 dpc expression is detected in the first and second branchial arches, pharynx and metanephros. At 12 dpc-14 dpc, expression was intense and strikingly confined to developing ectodermal organs. The vibrissae, tylotrich hair follicles, tongue papillae, and tooth germs as well as the ear auricle. Also expressed intensely in kidney epithelium in the stalk and tips of ureter as well as in the spermatic ducts in the testis. At 17.5 dpc strong expression was restricted to kidney tubules and ameloblasts in teeth, and moderate expression was observed in hair follicles, choroids plexus of the fourth cerebral ventricle of the brain. First detected on 12.5 dpc in interstitial cell of the testis and increased towards 14.5 dpc. On 8 dpp (day post partum) highly expression was detected in kidney and weakly in skin
+Expressed in embryos, larvae and adults (at protein level) (PubMed:14630920, PubMed:16857685). In larvae, only expressed in hypodermis and cuticle (at protein level) (PubMed:14630920, PubMed:16857685). Expressed in the ecdysed cuticle during molting (at protein level) (PubMed:16857685). Expression transiently increases during early embryonic stages and prior to the larval L2/L3, L3/L4 and L4/adult molts (PubMed:14630920, PubMed:16857685)
+Tightly developmentally regulated
+Detected in embryos, pupae, and adults but not larvae
+Maximum expression in adipose tissue during early development. In heart, low levels 6 days before birth increasing 278-fold as animals reach adulthood
+Expressed in early embryo and is later limited to the germ line. Expressed in the ectoderm and then in primordial germ cells (PGCs). Expressed in testis from 13.5 dpc to adulthood in gonocytes and spermatocytes. Also present in the developing and adult ovary as well as in the placenta and its precursor tissue, the ectoplacental cone
+Highly expressed in early and late stage osteoblasts of developing embryos (at protein level)
+Accumulates prior to flowering in the vegetative shoot apical meristem and after flowering in floral meristems
+Detected between 2 and 3 weeks after birth, in parallel with the onset of meiosis
+Highly expressed in hippocampus of 13 dpc embryos declining to low levels by 18 dpc and to undetectable levels in juvenile and adult hippocampus
+Maximally expressed during pregnancy until day 30 after which levels decrease significantly
+First observed in a dorsal domain of floral meristems, prior to any morphological dorsoventral asymmetry. Later, expression becomes restricted to the most dorsal half of each dorsal petals
+Expressed in brain and somites, and slight expression in cardiac primordium, at 18 hours post-fertilization (hpf) (PubMed:35039994). Expression is initiated at 22 hpf in the gut endoderm in an area known to be the origin of hepatic precursor cells and at 40 hpf, expands to the newly formed liver bud (PubMed:21471154). Expression is reduced after termination of primary liver formation (PubMed:21471154). Expressed in the brain, heart, and somites at 24 hpf (PubMed:35039994). Expression in somites becomes weaker, and is rarely detected from 48 hpf onwards (PubMed:35039994). Expressed in the cardiac region from 24 to 48 hpf (PubMed:35039994). At 48 hpf, expression is regionalized to the brain and heart (PubMed:21471154). At 96 hpf, almost no expression in heart, and expression is found to be accumulated in other tissues, such as the gill arch, swim bladder, and intestine (PubMed:35039994)
+At 16.5 dpc, specifically expressed in the interfollicular basal cells of the epidermis (at protein level). Detected in the marginal cells and cortical plate of the brain cortex from 16 dpc to P90 with high levels between 16 dpc and P0 and lower levels from P7 to adulthood (at protein level)
+Expressed in embryos, expression continues to the final stages of neurogenesis
+Expressed throughout pollen development with a peak at bicellular pollen stage
+Present in trace amounts on 5.5 dpc, increased remarkably from 6.5 dpc to a maximum on 9.5 dpc and rapidly declined thereafter to an almost undetectable level until delivery. First appeared at a considerable level in 3-week-old mice. Thereafter, the amount of transcript began increasing rapidly at 4-week-old mice and reached a maximum in 7-week-old mice
+Expressed in the cerebral cortex from 15.5 dpc reaching maximum expression at 17.5 dpc, expression remains robust until P30 (PubMed:20181826). Expressed in early elongating spermatids during spermiogenesis (PubMed:33228246)
+Expressed in the nervous system by the first larval stage
+Expressed both maternally and zygotically. Zygotic expression increases at stage 10 (early gastrula), continues during gastrula and early neurula stages before rapidly declining during neurulation
+First visible in 10.5 dpc embryos where expression is confined to the lens vesicles. Between 11.5 dpc and 12.5 dpc, expressed in both the lens epithelium and differentiating primary fiber cells. In the late fetal stage after the lens is formed, primarily found in the lens epithelium and the lens equator region where lens epithelial cells exit from the cell cycle and differentiate into fiber cells (at protein level). First expressed in the eye at 10 dpc embryos. Throughout eye development, expressed in the lens placode and forming lens pit. From 12 dpc, also detected in the midbrain region, tongue, incisor primordia, condensing mesenchyme around the sternum and vertebrae and in the head muscles
+The transcript levels of the gene accumulate in dry seeds and decay gradually during after-ripening and also upon seed imbibition
+Expressed from 7 dpc to 18 dpc throughout development
+Expressed in 4 to 5 weeks embryos
+Differentially expressed in development and capillary tube-like formation in vitro
+Accumulates during leaf and flower aging (PubMed:20113437). Induced by EIN2 during leaf aging, but negatively regulated by miR164, which expression decreases gradually with aging through negative regulation by EIN2 (PubMed:19229035). In leaves, accumulates at the tips and margins and in leaves undergoing senescence. Present in floral organs of partly or fully opened flowers, but not in young flower buds. Expressed in pollen grains of mature anthers, but not in immature anthers. In petals of open flowers mostly observed in the tip region. In mature siliques, accumulates at the abscission zone, in the distal portion of the valve margins and the tip. In roots, detected in primary and lateral roots, but not in root tips. In seeds present in embryos and the micropylar endosperm (PubMed:20113437, PubMed:23340744)
+In young seedlings, strongly expressed in cotyledons, and, at lower levels, in the hypocotyl adjacent region. Later confined to cotyledons vascular tissues and observed in leaf primordia and young growing leaves. Accumulates in the basal part of trichomes. In mature flowers, present in sepals, stamen filaments and stigma. Accumulates progressively in maturating siliques
+Expressed at fertilization and up to 2 hours post-fertilization (hpf), expression then declines to low levels at 4 hpf before increasing at 6 hpf onwards until 96 hpf
+Expressed in several tissues at different embryonic and postnatal stages such as the condensing mesenchyme of developing bones and developing nervous system. Expressed in the developing pituitary gland from 16 dpc and in developing thyroid C-cells from 14 dpc. In the ventral spinal cord, levels decline before birth. In the parathyroid, levels first detected in 3- to 6-week-old mice with high expression. In the adrenal medulla, expressed only in newborn, postnatal (P08) and adult mice. Isoform a1 and isoform b1 are prefentially expressed in 3-week-old thyroid, isoform a2 and isoform b2 in newborn and 6-week-old thyroid glands as well as in postnatal adrenal and pituitary glands
+Highly expressed during fruit ripening and flower development. In flowers, present at low levels during early developmental stages and later accumulates rapidly to reach a peak at the pre-blooming stage. Highly expressed in the sporogenous cells in the anther, pistil stigma and ovule and in basal vascular bundles. In fruits, accumulates progressively in the pulp with a maximum level at the pink stage. Highly expressed in the seeds, fruit peel and vascular tissues
+Expressed from egg to stage 35. Expression is restricted to the neural region as gastrulation proceeds, and is subsequently localized to neural tissues, branchial arches and pronephroi at the tail-bud stages
+Expressed notably in the spermatogenic cells from late pachytene spermatocyte stage till elongate spermatid stage
+First observed in the inflorescence meristem (IM) and young flower buds (PubMed:23335616). Detected throughout the floral bud. In young flowers, restricted to the inner whorls, specifically the petals, stamens, and carpels (PubMed:18417639, PubMed:23335616). In older flowers, accumulates more in the stamens than in the petals and carpels (PubMed:18417639). Observed in anther locules, vascular strands, and ovules (PubMed:23335616). During imbibition, expressed in the endosperm, especially at the time of testa rupture. Later restricted to the cotyledons (PubMed:20844019). In mature embryos, restricted to the cotyledons. In young seedlings, mostly expressed in shoot tissues, including the tip, circumference, and vasculature of the cotyledons, the emerging leaves, the meristematic region, and the basal part of the hypocotyl, and, at low levels, in the primary roots. In older seedlings, accumulates in the green shoot tissues (PubMed:22811435)
+Peak of expression in 8-day-old seedlings. Highest expression in the youngest leaf pair
+First detected in the boundary region of the shoot apical meristem (SAM) and the surrounding sheath. Expressed at low levels in vegetative organs, mostly in the sheaths. In inflorescence tissues, observed in the branch meristem and spikelet meristem regions, as well as in their vasculature and surrounding sheath (PubMed:17144896). Accumulates in incipient rudimentary- and empty-glume primordia (PubMed:22003982). Highly abundant in young developing panicles, but becomes later present at low levels in developing panicles and seeds. Found primarily in the boundary region of glume primordia (PubMed:17144896)
+Expressed from the early one-cell or late two-cell stage and continues throughout embryonic and larval development and in adulthood
+Abundantly expressed in the neural crest-derived structures with low expression in the neural tube at 10 dpc (PubMed:12088751). Expressed in the dorsal root ganglia from 10 to 17 dpc (PubMed:12088751). Expression in the neural tube increases from 11 dpc to 13dpc, at 13 dpc expression is particularly abundant in the diencephalon, brainstem and spinal cord (PubMed:12088751). Expression increases from 13 dpc to postnatal day 1.5 (P1.5) in the telencephalon, whereas expression in the diencephalic and brainstem decreases over this period (PubMed:12088751). Expressed weakly in the developing heart at 13dpc but not at later developmental stages (PubMed:12088751). Expressed weaky in the kidney from 13dpc through to adulthood (PubMed:12088751). Initially expressed in the retinae at 15 dpc, expression is maintained through to adulthood (PubMed:12088751). Abundantly expressed in brown fat beginning at 17 dpc, expression levels are reduced to a low level at P1.5 (PubMed:12088751)
+Expressed ubiquitously in the embryonic and extraembryonic tissues (PubMed:21149574). High levels are present in the chorionic plate (8.5 dpc and 9.5 dpc) as well as in and around the foregut and hindgut regions (9.5 dpc) (PubMed:21149574)
+Present in newly hatched larvae. Strongly expressed in the cuticle of fourth and fifth instar larvae. In epidermis, levels decreased with the increase in age of instars. In cuticle, levels increased with increase in age of instars
+Expressed from 12.5 dpc to 15.5 dpc in ovary and from 12.5 dpc to 14.5 dpc in testis, but to a lower extent. Expression is detectable in early embryos at 8.5 dpc and in brain of embryos at 13.5 dpc
+Embryonic, expression starting between days 1 and 10
+Expressed in epimastigotes (at protein level). Expressed in epimastigote, trypomastigote and amastigote stages
+First detected at 18 hours post fertilization (hpf), a stage when the otic placode begins to form the otic vesicle in zebrafish, and then increases throughout development
+Expressed zygotically. First expressed from the late blastula
+In floral organs, only observed in buds, pollen grains, pollen tubes and fertilized ovules (PubMed:29390074). Highly expressed in the anther tapetum at uninucleate and bicellular stages (PubMed:29390074)
+In the developing placenta, expressed during the morula (days 6-7) through the attachment stage (day 21). Expressed in the endoderm of day 14 blastocysts but then is down-regulated in these cells prior to implantation. Expressed on lateral surfaces of trophectodermal cells as attachment proceeded and is particularly intense in migrating binucleate cells at day 24 of development
+Expressed in testis from postnatal day 12 onwards, reaching maximal levels at postnatal day 30 (at protein level)
+Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan
+First expressed in the heart primordium at 8.5 dpc
+First detected in 15-20 mm buds. Expression increases as flowers develop
+Appears in endosperm 15 days post-pollination
+Expressed in the developing embryo and soon after birth but not detected in adults
+Expression during the neurula through tadpole stages of development
+Expression is maintained at a moderate level during larval feeding and wandering stages
+Expressed during embryogenesis (at protein level). Detected from 7.5 dpc to 17 dpc
+Not expressed in 8 and 10 weeks old fetuses
+Expressed transiently immediately prior to meiosis I during spermatogenesis in the male germ cell
+Expression is detected as early as embryonic day 12. Higher expression in spleen of post-hatch chickens than embryos. Gradual increase in expression in the spleen which peaks by day 7 post-hatch
+Expressed from stage 4 in the embryonic termini and at stage 5/6 in the ectodermal stripes. Expressed in the invaginating tracheal pits at stage 11, and ubiquitously throughout the embryo from stage 13. Expressed in the highly proliferative region of the eye-head primordium. Expressed in the distal regions of leg and wing imaginal discs. Expressed predominantly in embryo and pupae
+Seed ripening and germination
+Expressed in the developing fetal lung epithelium, embryonic ventral node and developing brain (at protein level) (PubMed:28666954, PubMed:27914912)
+Detected at multiple sites in embryonic day 10.5 embryos, including the genital ridges, the aortic endothelium and endothelium-associated cell clusters within the aortic lumen
+Highly expressed in 7 dpc embryos
+Asymmetrically expressed in Q neuroblasts during larval development. Highly expressed at the leading edge of migrating Q neuroblasts
+The protein first appears in meiotic spermatocytes and becomes abundant in spermatids around stage III-IV (at protein level)
+Highly expressed in ovules before fertilization, but turned off upon fertilization and not expressed in developing embryos or endosperm. Expression climbs again as the embryos mature
+Expressed in larvae, pupae and adults
+Observed during fruits development 25 weeks after pollination
+Present in all stages throughout the sporulation of the oocysts and in the sporozoites following excystation
+Expressed in both sporophyte and gametophyte phases of the life cycle
+Expressed at each stage of the cell cycle, including G0, although the expression is somewhat higher in late G1 and S phases
+Expressed from before gastrulation through to adult (PubMed:11274062). Expressed in HOB, PVX, and PVY neurons (PubMed:12954713). Expressed in most descendants of the ray precursor cells (Rn), including the ray neurons (RnA and RnB) and the ray structure cells at the L4 larval stage; rays are male-specific genital sensilla (simple sense organs) (PubMed:12954713)
+Present in oocytes and in embryos at the 4- and 256-cell stages before the mid-blastula transition (PubMed:11691838). Levels decline and are barely detectable by the fifth day of development (PubMed:11691838). At 21 and 35 days post-fertilization, expression is restricted to perinuclear stage oocytes (PubMed:17418113). Expressed throughout most stages of oocyte development with the highest levels restricted to stage Ib oocytes (PubMed:17418113)
+Expressed only in developing normal tissues
+Ubiquitously expressed in early development (PubMed:9618163). Highly expressed in neuroepithelium at 10.5 dpc, and in the forebrain, midbrain, frontal facial region, jaw, heart but not in the endocardial cushion, and cartilage primordial at 14.5 dpc (PubMed:19483677)
+Specifically expressed in seed endosperm at torpedo stage embryo development
+Transcripts are not detectable in the branchial arch epithelium before morphological tooth formation (10 dpc), but are highly expressed during the initiation of tooth development (11 dpc). Starting 12 dpc, expression is high and limited to the budding cells, and remains high in the fully developed enamel knot at 14 dpc, whereas all other dental cells were completely negative. During 15 dpc the enamel knot disappears largely through apoptosis, and no transcripts were detected in the tooth germs of newborns. In skin, uniformly distributed in the basal cells of the epidermis before follicle initiation. Expression becomes focally elevated before placodes become distinguishable. By 17 dpc transcripts are almost exclusively confined to maturing follicles and the recently initiated placodes
+Expressed in embryo and adult testis
+Expressed in germinating seeds up to 5 days after imbibition
+At 9.5 and 10.5 dpc, highly expressed in developing heart
+In oogenesis, expression is higher in previtellogenic oocytes
+Expressed specifically in the peri-implantation period in embryo and trophoblast and at low or undetectable level thereafter (PubMed:10464288). In embryonic skeletal muscle, levels significantly increase between 13.5 dpc and 15.5 dpc with maximal expression observed at 15.5 dpc (PubMed:23233679). Decreased levels in postnatal skeletal muscle (PubMed:23233679). In myoblasts, up-regulated soon after induction of myoblast differentiation (PubMed:23233679)
+Expressed at 12.5 dpc, 13.5 dpc and 14.5 dpc. Expressed in orofacial tissues, heart, liver, brain and limb bud. At 13.5 dpc, expressed throughout the ventricular myocardium, including endocardium and epicardium
+From 10 dpc to 12 dpc, it is weakly expressed throughout the embryo. At 14.5 dpc, it is predominantly expressed in a number of organ systems, including the central and peripheral nervous systems
+Expression begins in the uninucleate microspore, reaching a maximum in mature pollen
+Strongly expressed in adult germ cells and weakly expressed embryonic gonads (PubMed:25609838). In meiotic germ cells, begins to accumulate during the leptotene stage, before its concentration increases further during the pachytene and diplotene stages, where it localizes to the sex body (PubMed:25609838)
+Expressed from first larval stage to adult
+Expressed both maternally and zygotically. Expression increases from stage 11 (late gastrula), when the neural crest is induced, through to the neurula and tailbud stages
+Expressed from early embryos through to adulthood
+Expressed during erythrocytic stage of life cycle
+First expressed in embryos at the three-fold stage (PubMed:7958868). After hatching expressed in the syncytial hypodermal cells located throughout the body, pharyngeal muscle, seam cells P hypodermal blast cells, body muscle and anterior touch cells (PubMed:7958868). Expressed in the distal tip cell of the somatic ginad from the L2 stage of larval development through to the adult stage (PubMed:7958868)
+Highly expressed in anthers at stage 9 of development, before pollen mitotic divisions
+At 13 dpc, found in paravertebral vessels and dorsal root ganglia. At 14 dpc, in oropharyngeal epithelium, developing thymus and in the muscles of the tongue. By 15 dpc, in many tissues
+Expression appears in 17 dpc embryos, peaks 2 months after birth and decreases during aging
+Detected in elongate spermatids, and in caput and cauda epididymal spermatozoa (at protein level)
+Expressed during mid- and late-oogenesis (at protein level). Expressed throughout embryonic and larval development with peaks of expression during mid-embryogenesis and at third larval instar
+Weakly expressed throughout the embryo, except in the developing nervous system, the ribs and the liver, but markedly up-regulated at discrete sites during development. At 6.5 dpc, prominent expression observed in differentiated decidua. At 7.5 dpc, intense expression in extraembryonic endoderm, amnion and nascent mesoderm. At 8.5 dpc, abundant expression in somites and yolk sac followed by a confinement to dermamyotome compartment. Between 9.5 dpc and 11.5 dpc, abundant expression in AER (thickened ectodermal cells of limb buds). At 12.5 dpc, expression in the limbs is confined to the condensing mesenchyme surrounding the cartilage. At this stage, strong expression also detected in vertebral and facial cartilage primordia and in the muscle of the tongue. At 16.5 dpc, abundant expression in epithelial cells of the intestinal villi. Isoform A is most abundant at all stages but significant levels of isoform B occur at 12.5 dpc
+In early-stage flowers, expressed in all floral organs. Becomes later restricted to the gynoecia, preferentially to the outer cell layers that give rise to the valves. No expression in flowers at anthesis
+Oocytes and early embryonic stages up to its elimination
+Highly expressed in 7 dpc and to a lower extent in 11 dpc, 15 dpc and 17 dpc embryos. Expressed at 16.5 dpc in the lateral regions of the cortex
+Low and continuous expression throughout whole developmental stages
+At 9.0 dpc, expressed in the ventral tail bud and also in the closing anterior neuropore and in the roof of the neural tube, at 10.5 dpc, also expressed in mesonephric ridge
+Expressed in fifth instar larva (PubMed:26780217, PubMed:27106120). In the silk gland, highest level on the first day of 5th instar larva, then displaying a decreasing trend daily. In the fat body, expression level is high in the early and late stages, and low in the middle stage of 5th instar larva (PubMed:26780217)
+In seedlings, expressed in the subapical region of the primary roots, in lateral root primordia, in developing trichomes and in stipules. In flowers, observed in pollens, embryo sacs and embryos. In roots, present at low levels in the stele. When grown on callus-inducing medium (CIM), accumulates strongly in the root stele where callus formation starts
+Not detected in the meristem prior to exposure to long days (LDs), but after exposure to three LDs, stable accumulation on the flanks of the meristem adjacent to floral primordia, during floral induction
+It is first expressed at the midblastula transition and is maximally expressed at the late gastrula-early neurula stage. It is expressed in two distinct periods, the early period is characterized by an anteroposterior graded expression in the mesoderm with the highest concentration at the posterior end. The late period begins at the tailbud stage and is characterized by new expression in the CNS, predominantly in the brain, and in addition it is also expressed in the tail bud at this stage
+At 12.5 dpc, expressed in the developing nervous system, particularly in the spinal cord, dorsal rootganglia, hindbrain and midbrain
+Detected throughout embryonic development (PubMed:11180838). Detected within the animal pole region at the four-cell stage, then in the anterior neural plate at the neurula stage, and within the head region including the otic vesicles, branchial arches, and the tail region at the tailbud stage (PubMed:11180838, PubMed:25946333)
+Protein kinase activity is low in vegetative cells, rising sharply during sporulation; during germination its activity decreases to its original level
+Expressed in anthers at the uninucleate microspore stage and the bicellular pollen stage
+Expressed in embryo at 14 dpc
+Expression increases in myelinating Schwann cells during the initial period of active myelination
+Expressed during fetal development
+Expressed in every developmental stage. Up-regulated by senescence
+Expression levels increase during erythrocyte differentiation
+Expressed maternally in immature oocytes at high levels but is scarcely detectable in mature oocytes or in embryos at the morula and blastula stages
+In flowers, expressed in anthers, stigmas and styles
+Expressed mainly in the aleurone and, to a lesser extent in the embryo, throughout the 5-days germination period exclusively, with a maximal level at 3 days. Also found in the roots and shoots of the growing seedling
+Expression in testis already detected at postnatal day 1 (P1), progressively increases with adult levels reached at P20
+Expressed both maternally and zygotically. Expressed in all developmental stages; highest in embryos, decreasing during early larval development (L1-L3) until the fourth larval stage (L4) where it increases. Expression in hermaphrodite adults is mostly contained to the germline
+First detected in the mesoderm at stage 7.5 dpc. During neurogenesis (9.5 dpc to 10.5 dpc), predominantly expressed along the anteroposterior axis of the CNS in the mesencephalon, metencephalon, rhombencephalon and spinal cord, with expression excluded from the midbrain-hindbrain junction. Beginning at 9.5 dpc, expression is found in the epithelial component of the branchial arches and foregut. At later stages, expressed in somites. At 10.5 dpc, expressed in the cephalic mesenchyme surrounding the optic vesicle. By 12.5 dpc, expression remains in the mesenchyme and also begins in the neuroretina, and at 16.5 dpc expression is exclusively located in the inner neuroblast layers of the neuroretina. Starting at the otic vesicle stage, shows regionalized expression in the developing inner ear with expression in the entire otic vesicle from 10.5 dpc onwards. Expressed in distinct patterns in the developing limb buds from 10.5 dpc onwards. Expressed in the developing heart in the ventricular septum from the onset of its formation (10.5 dpc) onward. In fetal stages, expression becomes confined to the myocardium of the atrioventricular bundle and bundle branches of the forming ventricular conduction system
+Expression was first detected at HH stage 10 and was initially expressed throughout the heart. With heart looping at HH stage 11, expression was restricted to the atrial compartment and absent from the presumptive ventricular segments. The atrial-specific expression was still observed at stage 17. During HH stages 17-24, increased expression in the subepicardial compact layer was seen. At HH stage 30, expression was seen intensely in the whole myocardium with the exception of the outflow tract
+Expressed predominantly in anterior and dorsal structures and most strongly in the brain of the tailbud (stage 26) embryo
+At 13.5 dpc, it is present in endoderm derivatives, such as tongue, palate, epiglottis, pharynx, and esophagus. Later in embryogenesis, it is detected in the choanae and whiskers
+Expression increases during oligodendrocyte differentiation. Detected in spinal cord in late fetal (18.5 dpc) and early postnatal (P3 and P7) stages. Expression decreases in later postnatal development (P14 and P30)
+In seedlings, strong levels in the hydathode region of cotyledons as well as in the upper part of hypocotyls and weak content in the vascular tissue of cotyledons (PubMed:20011053). In developing leaves, strongly expressed in the midrib of leaf veins, but weak levels in the hydathode regions (PubMed:20011053). In developing flower buds, accumulates in pistil tips and the vascular tissue of stamens and sepals (PubMed:20011053). In mature flowers, detected in the vascular bundles between the two anther locules, the central vascular cylinders of the filaments, vascular tissues of tips and bases of the pistils, and sepal vascular tissue (PubMed:20011053). Also present in tips and bases of developing siliques, and progressively restricted to the vascular tissues at the silique tips (PubMed:20011053)
+Expressed at all developmental stages, with lowest levels at the adult stage (at protein level) (PubMed:12408809). Uniformly expressed along the dorsoventral axis of embryos (at protein level) (PubMed:14667416). At the periphery of syncytial blastoderm embryos, expression is often weakest at the anterior and posterior termini (at protein level) (PubMed:14667416)
+At 2-3 days post-fertilization, detected in eye, forebrain, midbrain, hindbrain and anterior spinal cord
+At stage 25, expressed throughout the eye field. At stage 40, expression becomes restricted to the retinal pigment epithelium
+Weakly expressed in the neural tube around 8.5 dpc. By 9.5 dpc, expression is prominent in the ventral brain and spinal cord, and weak expression begins in the retina. At 10.5 dpc, highly expressed in the trigeminal and dorsal root ganglions, and the ventral midbrain and hindbrain. At 12.5 dpc, expressed in the mantle layer of the brain and spinal cord, trigeminal ganglion, Rathke's pouch, dorsal root ganglion and the ventricular zone of the neural retina. At 16.5 dpc, expression becomes restricted to the anterior region, persisting in the diencephalon and neural retina but decreasing in other regions
+Detected at embryonic days 15.5 and 17.5. Expressed in the developing lower urinary-tract structures, with emphasis on the genital tubercle above the phallic urethra and below the pelvic urethra at as early as embryonic day 13.5 dpc, the critical time point for urethral development. In embryos, expression is also visible in the brain, in the mandibular region, and in dorsal parts above the spinal cord
+Primarily expressed in the central cell gamete of nonfrtilized ovules, which upon fertilization gives rise to the endosperm, and later in the micropylar endosperm, which surrounds the embryo
+First appears in immature seeds and is maximally expressed in dry seeds
+Expressed during early embryogenesis and neurogenesis in a biphasic manner
+Detected in embryos, adult males and females
+Present in all growth stages and in both inner and outer forespore membranes
+Expressed both maternally and zygotically throughout early development, with expression peaking at the neurula stage
+Developmentally regulated gene in heterocyst development
+Expressed in whole larval extracts, fat body and larval brain (PubMed:29127204). At prepupal stages, expressed towards the wing margin; during the junctional remodeling phase relocalizes to intracellular compartments; before prehair formation, enriched at P-D membranes (at protein level) (PubMed:23292348)
+Only present in alpha-cells (classes II and III)
+Expression begins around postnatal day 20, which roughly corresponds to the haploid, round spermatid stage of spermatogenesis
+At 16.5 dpc, present in skull base cartilage (at protein level) (PubMed:18757743). Expressed in the floor plate as early as 9.5 dpc and shifted to the central canal area from 13.5 dpc. At 15.5 dpc, the expression is restricted to the ventral midline region (PubMed:25331329)
+Expressed at 11.5 dpc in spinal chord
+Maternally provided it is detected at all tested stages of development
+Expressed in heart, neural tube, forebrain, mandible, tongue and body walls at 10.5 to 14.5 dpc (at protein level) (PubMed:24895408). Expressed in lung, stomach, brain, heart, kidney and gonads at 14.5 dpc (PubMed:11527402)
+Detected in the anterior primitive streak preceding the morphological appearance of the node at 7.0 dpc. Expressed in the node and in the midline notochordal plate cells extending anteriorly from the node at 7.5 dpc. At 8.5 dpc, expressed in the node now located in the tail region. At 9.5 dpc, detected in the floor plate and in the dorsal portion of the neural tube, with highest expression in the anterior portion of the spinal cord. Also expressed in the developing gut. At 10.5 dpc, also observed in the telencephalon region of the brain and in the anterior portion of the limb bud at 12.5 dpc (PubMed:26248850). Localizes to cells at the posterior margin of the ciliated organ of asymmetry (PubMed:22233545)
+Expressed transiently during the development of several organs such as lateral roots, rosette leaves and most floral organs
+In larvae, detected in neuroblasts (at protein level) (PubMed:22357926). Mesectodermal expression appears shortly before the onset of gastrulation (PubMed:2540957). In imaginal disks, expression is seen primarily within presumptive proneural clusters of eye-antennal, wing and leg disks (PubMed:2540957)
+Isoform 2 and isoform 3 are expressed in heart at 12.5 dpc (at protein level). Expressed in the heart at 9.5, 12.5 and 15.5 dpc. Isoform 2 and isoform 3 are expressed in heart at 9.5 and 12.5 dpc
+Not expressed prior to gastrulation in embryo, while it is expressed before in extraembryonic lineage cells destined to form the chorion (PubMed:7789278). Expressed in both embryonic and extraembryonic lineages during mouse embryogenesis (PubMed:7789278)
+Expressed in neuronal precursor cells during embryogenesis (PubMed:9187144, PubMed:27487365). Expressed in nerve ring ganglia neurons in very early larval stage L1, which is undetectable by early larval stage L1 (PubMed:18586090). During L1, expressed in the P cell lineage, specifically in the ectodermal-like P cells, and expression persists in the primary and secondary neural precursors of the P cell lineages (PubMed:18586090). Later, appears to be expressed in all 53 of the resulting postmitotic motor neurons during larval stage L1 (PubMed:18586090). Expression in most of these neurons is undetectable by larval stage L2 (PubMed:18586090). Also expressed in the hermaphrodite-specific motor neurons (HSN) and in the ventral type C (VC) motor neurons throughout larval development (PubMed:18586090). Expression in the HSNs persists until late L4 larval stage (PubMed:18586090)
+Expressed at 45 dpc
+Adult levels are reached by day 16 after birth
+Expressed only in the liver of young adult animals (100 days old) and is absent in the prepubertal male (27 days old), senescent male (800 days old) and female liver
+Expression increases through development and peaks at postnatal day 14
+Expressed strongly in embryo at 7 dpc. Expressed slightly in embryo at 11, 15 and 17 dpc
+Increases between day 8 and 16 of embryonic development, during aortic embryogenesis, in direct proportion to total protein synthesis
+Expressed in pstO cells (and not in pstA cells) throughout development
+Levels of n-octanoylated and n-decanoylated ghrelin drop by one third and 3-fold, respectively, between postnatal weeks 3 and 4 due to change of diet during weaning
+Expressed throughout the developing brain from 11.5 dpc through 17 dpc, continues to be expressed at P0, but then is down-regulated
+Expressed early in embryo from embryonic day 2 onwards
+Expressed ubiquitously in sodium-stressed and non-stressed protonemata (PubMed:17556514). Expressed in the stem, basal part of the leaves, and in a small number of rhizoids originating from the base of sodium-stressed and non-stressed gametophytes (PubMed:17556514)
+First expressed during early gastrulation. Expression peaks during neural induction and early organogenesis
+In the developing respiratory system, expressed in epithelium of trachea and lung at 12.5 dpc and 14.5 dpc but not detected in distal epithelial tips. Expressed in the mesenchyme adjacent to the proximal conducting airway epithelium at 14.5 dpc but not at 16.5 dpc. Epithelial expression persists at 16.5 dpc. At 18.5 dpc, high levels detected only in epithelial cells of terminal sacules. In the developing gastrointestinal tract, expressed in the esophageal mesenchyme and epithelium of posterior stomach and intestine. In the developing skeleton, expressed in the perichondria of the neural arch of developing vertebrae at 14.5 dpc and 16.5 dpc. In developing skin, expression is restricted to basal layers of the epidermis at 16.5 dpc
+Expressed in testicular germ cells during and after meiosis in the course of spermatogenesis, while it is not expressed in premeiotic or early meiotic testicular germ cells
+Expressed during the asexual blood stage, predominantly at the ring and schizont stages (at protein level)
+Highly expressed during embryonic development with higher levels in first instar than in third instar
+Expression correlates with proliferation in some types of cells
+Starts to be expressed at the end of S phase, reaches a peak at mitosis and then decreases
+Expressed at all developmental stages, highest expression is in the adult
+Appears to be expressed by primary and secondary spermatocytes and spermatids. Detected in oocytes within the primary follicles. It is also present in secondary oocytes
+Expressed at all embryonic days examined in the neural tube and the forebrain, midbrain, and hindbrain. Also detected in the branchial arches and limb buds, particularly along the progress zone. Expression is low at 8.5 dpc but increases at 10.5 dpc
+Expressed in testis and ovary at 15.5 dpc
+Maternally expressed but its transcription is not limited to the female germline
+Expressed mainly in exocrine glands and bone precursors in the embryonic mouse (PubMed:7693055)
+Expressed both maternally and zygotically, from ova through to 48 hours post-fertilization. At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 5. At the 20-somite stage, expressed in the developing CNS with an anterior expression adjacent to the somite 3/4 boundary
+Expressed in headfold stage embryos in the notochord, the anterior neuroectoderm, and a few cells of the definite endoderm. This expression becomes restricted to the anteriormost portions of the invaginating foregut and the developing midbrain. From day 11.5 of gestation onward, FOXD4 transcripts are restricted to the midbrain and become progressively localized to the red nuclei as the sole site of expression
+In primary foreskin keratinocytes, down-regulated during calcium-induced differentiation (at protein level). The physiological relevance of this observation is unclear as YIPF4 protein is expressed throughout the epithelial layers in organotypic raft cultures, a cell-culture model of stratified epithelium
+(Microbial infection) Down-regulation upon calcium-induced keratinocyte differentiation is prevented in the presence of human papillomavirus (HPV), independently of HPV E5 protein (at protein level). The physiological relevance of this observation is unclear
+Highest level in adult female brain, lower levels in adult male brain. Expressed in the brain of sixth larval stage with decreasing levels in prepupae, young pupae and 10 day old pupae
+First expressed at the dorsal intermediate region of the neural tube at the 5-somite stage, expression is extended along the rostral caudal axis by the late stages of segmentation (PubMed:19216761). Expressed at the presumptive fin bud at 24 hours post-fertilization (hpf) and then at the fin bud at 48 hpf (PubMed:19216761)
+Expressed in the developing brain from 10.5 dpc until 14.5 dpc. The expression decreases after 16.5 dpc, but an up-regulation is observed at P5 and the expression remains constant thereafter
+Expressed in all interphase nuclei throughout development
+Expressed after gastrulation (post stage 13)
+Absent early during embryogenesis (7 dpc), present at the middle stage (11 dpc) and highly expressed at the later stages (15 dpc and 17 dpc) (PubMed:24361185). Specifically expressed in the somites at 11.5 dpc and in the skeletal muscle at 15.5 dpc (PubMed:24361185)
+Expression starts at stage 32
+Expression is low at 7 dpc, reaches a maximum at 15 dpc and decreases at 17 dpc
+Not expressed in embryo. Expression starts at 5 weeks
+At 9.0 dpc, selectively expressed in cells of the developing nervous system and from day E.5 onwards, expressed ubiquitously
+Expressed from 1 to 3 days after flowering mainly in the maternal tissues of the developing caryopsis, corresponding to the early grain filling stage
+Expressed in all fetal tissues examined, included brain, lung, liver, and kidney. Protein levels peak at G1 and decrease through S-phase
+Expressed during the asexual blood stage
+Initiated in the neuroectoderm before that of dld. In the developing trunk neural plate and neural tube, it is initiated in the epiblast prior to completion of gastrulation. At the 2- to 3-somite stage (10.5 hours) low levels are distributed throughout the trunk CNS, with cells expressing higher levels found in the medial and lateral regions of the neural plate. These regions correspond to the positions at which primary motoneurons and Rohon Beard neurons (RBs) originate. Cells expressing high levels do not form contiguous domains. Rather, single cells or small clusters of several cells showing high expression are interspersed with cells having lower expression. Expression is specific to the developing nervous system, and continues to be expressed broadly in the CNS throughout neurogenesis. Expressed in cells specified for neuronal fates. At 24 hours, and throughout later embryogenesis, it is broadly expressed in the spinal cord, suggesting that it is expressed by many types of cells. Expressed as neuronal specification occurs and is subsequently down-regulated in cells that have acquired specific neuronal fates
+Expressed at the first stages of flower development, and converted into its mature form as the flower matures, accumulating until the later stages of flower senescence. During flower development at the mRNA level, the highest expression is detected in closed capitula and no mRNA was detected at later stages of floral development. At the protein level, highest expression of mature cardosin-A is detected in fully opened capitula. Detected at mRNA level in the embryo fraction of dry seeds. Not detected in developing seeds until 72-84 hours of hydration, where it is detected in the embryo and remains in subsequent developmental stages. At protein level, the precursor form is detected in the hydrated seed until 120 hours, an intermediate form is detected at almost all stages, and the mature protein is detected until 60 hours and reappears before the seedling stage
+During development it is expressed in subregions of the nervous system and is particularly prominent in muscle (PubMed:9361278, PubMed:32169168). Expressed at embryonic day 18.5 dpc (PubMed:32169168)
+Expressed in zygote and ookinete (at protein level) (PubMed:26911483). Expressed in gametocytes, zygote and ookinete (PubMed:26911483)
+60-fold stronger expression found in adult than fetal testis. Detected in spermatocytes and round spermatids of the seminiferous tubule
+Expressed throughout the development in embryo at 10.5 dpc. Expressed in the central nervous system at 12.5 dpc. Expressed in the ventral part of caudal diencephalon at 12.5 dpc. Expressed in the dorsal root ganglia at 12.5 dpc. Expressed in the kidney and lung at 12.5 dpc. Expressed in the dorsal and ventral midbrain at 18.5 dpc. Expressed uniformely in the cortex at 18.5 dpc
+Expressed in the anterior region of the blastoderm embryo
+Developmentally regulated to start immediately before spore formation
+Expressed during the asexual blood stage, including the trophozoite and schizont stages (at protein level)
+Detected in testis from 1 day postpartum (dpp) onwards (at protein level). Expression increases through to 28 dpp and remains high thereafter (at protein level). Highly expressed in spermatocytes at leptotene and pachytene stages of meiosis
+Expressed during oocytes meiosis
+During murine development it is initially expressed in the hindbrain and first branchial arch, while in late stages of embryogenesis, it can only be found in tooth buds and in inner ear structures (PubMed:12915310, PubMed:15872003). At E8.0, it is specifically expressed in prospective rhombomeres 2 (r2) and 4 (r4), and in the rostral portion of the first branchial arch (PubMed:12915310, PubMed:15872003). At E8.5 it is expressed in the mid-portion of the neuroepithelium of the prospective hindbrain and the branchial arch ectoderm (PubMed:12915310). By E9.5, its expression is observed in the maxillary and the mandibular components of the first branchial arch, in r2 and in the lateral epibranchial placodes (PubMed:12915310). By E10.5, it displays a specific pattern of expression in the cervical mesenchyme and is restricted to a few cells ventral to the pontine flexure (PubMed:12915310). By E11.5, its expression is confined only to a narrow band in the lateral cervical mesenchyme (PubMed:12915310). At E12.5, it is expressed along the mouth epithelium and at the level of the dental lamina, as well as in the cervical mesenchyme caudal to the otic vesicle (PubMed:12915310). By E14.5 there is strong expression in the dental epithelium (presumptive enamel organ), whereas it almost disappears from the mouth and tongue epithelium (PubMed:12915310). By E15, strongly expressed in a stripe across the retina (PubMed:15531370). At E16.5 expressed only in the enamel organ (specifically the inner dental epithelium) of the various tooth anlagen (PubMed:12915310). At E18.5 it is highly expressed in the second molar, but almost absent in the first molar epithelium (PubMed:12915310). Expression continues for several days postnatally, and persists longer in the temporal than nasal retina, disappearing around P14 (PubMed:15531370)
+At 6.5 dpc expressed throughout the embryo with relative abundance in the visceral endoderm
+Expression begins at 80% epiboly and is extinguished by 48 hours post-fertilization
+In embryos, expression is first seen in pharyngeal primordium and later in all differentiating cells. Post embryonic expression corresponds to developmental patterns of cell cycle progression in many tissues including sex myoblasts, distal tip cells, vulval cells, seam cells, neurons, intestine cells and hypodermal cells (PubMed:10587644, PubMed:9716524). During the development of distal tip cells (DTC), expressed asymmetrically between the daughters of the Z1.a and Z4.p cells; asymmetric expression is regulated by wrm-1, a component of the Wnt/MAPK pathway (PubMed:17476329)
+Constant expression during germination
+Levels fade progressively in a basipetal fashion as the leaf develops. In the epidermis of cotyledons and leaves, observed in dividing and recently divided stomatal precursor cells, especially in dividing guard mother cells and young guard cells. Also present in asymmetrically dividing meristemoid mother cells and meristemoids. In roots, expressed preferentially in the division zones of root tips
+Widely expressed throughout the anterior head region, including the central nervous system, the eye and branchial arches at 24 hours post fertilization (hpf). Expressed strongly in the brain region. By 40-48 hpf, expression remains strongly expressed in the head region but is reduced throughout the rest of the embryo (PubMed:30424580). Expressed in the heart and tail regions throughout developmental stages (PubMed:29174768)
+Expressed in the epiblast at 5.5 dpc, expression extends into the extraembryonic ectoderm at 6.5 dpc, and at 7.5 dpc expressed in embryonic ectoderm, allantois, amnion and chorion. From 8.5 to 9.5 dpc, ubiquitously expressed in the developing embryo
+Ubiquitously expressed throughout the development
+At 8.5 dpc, expressed in the neural tube, most notably in the rhombomere of the future hindbrain. By 10.5 dpc, expressed throughout the brain, the length of the neural tube, the growing edge of the limb buds, heart, and eyes. Strong expression is observed in the kidney at 14.5 dpc
+Expressed during the parasite blood stage, specifically in schizonts and free merozoites (at protein level)
+Expressed exclusively in the spermatids at steps 9-14 of spermiogenesis (PubMed:23553430)
+Expression remains constant during vegetative growth, decreases during early sporulation, and is induced in the forespore during late sporulation
+Induced in seeds during silique ripening
+Embryo and neonate express predominantly acidic isoforms while all adult isoforms are basic. Only one isoform, B2e17, is found in both embryo/neonate and adult. A transition from high to low molecular weight isoforms is also seen during postnatal development
+At 7.5 dpc, expression is detected in the ectoplacental cone but not in embryonic tissues. By 9.5 dpc and 12.5 dpc, strongly expressed in the giant trophoblast, spongiotrophoblast and decidual cells of the placenta (at protein level). At 9.5 dpc and 11.5 dpc, weakly expressed in the developing embryo
+Transiently expressed at the protein level in the zygote upon fertilization. No longer detected by the time of the first division
+Expression decreases as fruits matures
+Expressed in embryos at 2, 4 and 6 dpc
+In the embryo, expression begins at day 14 and coincides with the onset of primary myogenesis
+Expressed ubiquitously. Not detected during germination
+Induced by 2-fold during pregnancy, including in abdominus rectus muscle
+Expressed at embryonic day 20, postnatal days 1, 7, 14, 36, six months and one and a half years. Highest level at 20 dpc. In muscle, expression is over 10 times higher at 20 dpc and during the early postnatal period than in adults. In adults, expression levels are several-fold higher in brain, particularly in the cerebellar cortex, than in muscle
+Expressed transiently during early panicle development
+Expressed both maternally and zygotically. Isoform a and isoform f are more abundant than isoform b and isoform e, but their temporal patterns of accumulation are similar. All are present in adult germline, pregastrulation embryos, later embryos and adult soma
+Expressed in the dopaminergic neurons of the olfactory bulb at postnatal day 0 (at protein level)
+Expressed in the developing nervous system, the somites, heart and craniofacial region. Expressed in the myocardium of the atrium at 9.5 dpc and in the atrioventricular cushions from 9.5 dpc to 12.5 dpc. Also expressed in developing and adult retina. Expressed in the ventricular zone of the ventral spinal cord at 12 dpc and in the ventricular zone of the telencephalon at 12 dpc and 15 dpc. Weakly expressed in the cortical plate at 15 dpc
+Not expressed in early postnatal somatosensory cortex at postnatal day 1 (P1): weakly expressed at P2, coincident with innervation by thalamocortical axons into layer IV cortex, followed by a barrel-like expression pattern established over the next few days
+Expression starts at 16 dpc in the cerebral cortex and increases to reach a maximum 20 days after birth. Then it decreases till adulthood to be expressed half of the peak level. In the retina, expression reaches a maximum at postnatal day 14 (P14). It starts weakly at 16 dpc in the retinal pigment epithelium (RPE). At P0 it is detected in nerve fiber layer (NFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and RPE. At P7, it becomes intense in the NFL and IPL. At P14, expression becomes intense in the area of outer segments (OS) of the photoreceptor cells as well as in RPE, whereas in the inner layers it becomes gradually fainter. From P21 to P42, it decreases in inner retinal layers. OS and RPE still express, whereas expression in the NFL and IPL decreases (at protein level)
+Expressed in the dorsal neural tube
+Expressed at low levels in vegetative cells and at high levels in prespore and prestalk cells during development. Developmentally regulated. Not observable before the end of aggregation, peaks at the mound stage and remains at a lower level thereafter
+In young developing fibers
+During seed germination, predominantly expressed in the radicle and, to a lower extent, in hypocotyls
+Detected at comparable levels in embryonic brain and in brain from ten day old animals (at protein level) (PubMed:16872596). Detected in neuroectoderm at 7.5 dpc. Detected in midbrain between 8.5 and 9 dpc (PubMed:18448090). Detected at 9.5 dpc in embryonic midbrain adjacent to the boundary between midbrain and forebrain (PubMed:16872596). At 10.5 dpc, expression is also detected in the eye, throughout the brain, the dorsal root ganglia and trigeminal ganglia, and in cells adjacent to the urogenital ridge in the torso (PubMed:16872596, PubMed:18448090). At 11 dpc, expression in midbrain is tightly restricted to the boundary between midbrain and hindbrain (PubMed:16872596)
+Expression in neutrophils occurs in the late terminal differentiation phase
+First detected in the lens placode at stage 11, when the head ectoderm makes contact with the optic vesicle. The expression remains restricted to the invaginating lens placode, and subsequently to the developing lens vesicle. In 8-day old embryo, almost exclusively expressed in lens with very weak expression in brain
+Expressed periodically during the cell cycle with peak mRNA levels occurring at the late M/early G1 phase, prior to budding, and levels decrease rapidly as cells enter into the S phase. In early G1 peak occurs (at protein level)
+Expressed in all embryonic epithelial cells
+In embryos at stage 20, expressed in the eye vesicle, and later in the neural tube, olfactory placode, midbrain and hindbrain. In addition to expression in the CNS at stage 29, expression is also visible in the pronephros, otic placodes and tailtip. Expression in the eye is localized to the retina. Broadly present throughout the midbrain and hindbrain and expression is not limited to the proliferating cells of the ventricular layer, but detected throughout all layers of the hindbrain
+Up-regulated during HL60 cell differentiation into macrophages (at protein level)
+Detected from embryonic stage 15.5 onwards. At stage 17.5 dpc, detected in epidermis and developing hair follicles. Expression levels in skin increase 4 days after birth and are mainly restricted to differentiated layers of the epidermis
+At an early stage, highly expressed in the branchial and pharyngeal arches, but not in the brain. Expression in the brain starts at 15 dpc (at protein level)
+Specifically expressed in the hypophysis of the majority of early globular embryos, approximately one round of cell division after the 16-cell stage, but never at the 16-cell stage itself. After the division of the hypophysis, it is detected in the upper lens-shaped cell that gives rise to the QC, but not in the lower daughter cell that gives rise to the central root cap. Subsequently, in heart stage and bent cotyledon stage embryos, it is detected in the four cells of the QC, which are the direct descendants of the lens-shaped cell. Also expressed in patches of cells that appeared associated with the vascular primordium of the cotyledons. This expression is strongest in late heart stage embryos and then gradually decreases
+Detected at constant levels throughout embryonic development (at protein level). Detected at high levels at the four cell stage of embryogenesis, followed by a steady decline until gastrulation. Detected at low levels throughout further stages of embryo development. Primarily expressed in the head region during gastrulation, and in the neuroectoderm during neurulation
+Strongly expressed in both limb and genital buds as is the case for Evx2 and Hoxd genes, in particular Hoxd13. In developing limb buds, it is first seen in 10.5 days old fetuses, in the posterior distal bud, to subsequently extend throughout the distal aspect, in presumptive digits
+Expressed in late embryogenesis, larval stages L2, L3 and L4 and in adults
+Expressed in embryo at 10 dpc onwards (at protein level)
+Detected in the generative cell of bicellular pollen. Also expressed in uninucleate microspores
+Abundant in whole fetus but decreases rapidly after birth. In adults is highly expressed in the adrenal, present in the brain and uterus but undetectable in the heart
+Expression in seminiferous tubules overlaps with the onset of meiosis, starting from spermatocytes of the late pachytene stages and proceeding throughout meiosis to the round spermatids. Detected in nearly all stages of spermiogenesis (at protein level)
+Expressed in L4 larval stage primarily in neurons, including ventral cord neurons DA, DB, VA and VB; the lateral excretory canal associated CAN cells; and anterior neurons AVK, DVA, I5, M1, M2, M4 and M5
+Expressed throughout ovarian development (5-32 weeks post-fertilization (wpf)). Expression tends to be higher at 14 and 17 wpf
+During the early stages of embryo development, first observed at the transition stage. In the heart and torpedo stages, predominantly present in the upper part of embryos. In seedlings, strongly expressed in shoot meristems, hypocotyls, in the vascular bundles of cotyledons, and in the veins of mature leaves. In reproductive organs, detected in inflorescences, especially in sepals, filaments, and stigmas, as well as in mature siliques and seeds
+In embryos, widely expressed in nerve cells innervating the central nervous system (CNS) in regions including the olfactory bulb, midbrain tegmentum, preoptic region, dorsal thalamus, posterior tuberculum, postoptic commissure, hindbrain, and lateral margin of the spinal cord (PubMed:27315774). In the spinal cord, expressed in various neuronal cell types throughout the dorsoventral axis, including motor neurons and interneurons (PubMed:27315774). In the postoptic commissure, anterior commissure, hypothalamus and pituitary gland, expression overlaps with gal (PubMed:27315774). In larvae, expressed in nerve cells in the dorsal spinal cord where expression often overlaps with spx1 (PubMed:30903017)
+Specifically expressed in germ cells tightly related to meiosis. In the developing mouse testis, it is not detected in the testes of 14-day-old mice, when pachytene spermatocytes are still in their early stage, while it is detected in tubules with late pachytene spermatocytes and spermatids in the testes of 21-day-old mice
+Highly expressed at the early seedling stage
+Found diffusely on the lateral membranes of Sertoli cells in the early prepubertal period. With development, became gradually concentrated at the most basal regions of Sertoli cells
+Detected in neonate myocardium; levels are low directly after birth but high five to fifteen days after birth, and not detectable in adults
+Expressed from embryonic 8 days post-coitum (dpc) throughout the subsequent stages of formation of the cardiovascular system (PubMed:10473142)
+Expressed throughout development, highest expression is during pupal stage. Isoforms A, C and D have lowest expression levels
+Restricted to the aggregation stage of development in D.discoideum. No detectable activity in cell adhesion
+Not expressed in embryos, but expressed at all larval stages of development and in adults
+Expressed specifically in the quiescent center (QC) of the root apical meristem (RAM)
+In young seedlings, detected in the hypocotyl, cotyledons and rosette leaves,mostly in expanding leaves. At flowering time, expressed in stems, cauline leaves, sepals, and, in closed flowers only, in anthers. Later present in pedicels of developing siliques, nectaries, and along the length of maturing siliques
+Expression found as early as 18 dpc in developing retina. From P3 to P6, expression increases in developing rods. Expression, thereafter, in the future inner nuclear layer migrating to the final destination of the outer nuclear layer. In the mature retina, exclusively expressed in rods
+Expressed in oocytes at the prometaphase and metaphase of meiosis I (at protein level). Expressed in early embryo at the prometaphase and metaphase of mitosis (at protein level)
+Strong expression in the liver of 14 dpc embryo and in brain, spleen, liver, kidney and intestine of an 18 dpc embryo
+During the cell cycle, expression peaks at the G1/S transition
+Expressed in developing caryopses from 1 to 7 days after flowering (DAF) and then declines to nearly undetectable levels by 15 DAF
+Expressed predominantly from early- to mid-stage mouse embryogenesis. Detected throughout embryos from 7.5 to 9.5 dpc but localizes predominantly in the brain, faces, branchial arches, limb buds, and tail buds of embryos at 10.5 dpc
+Expressed from day 10 in the embryo. Maximum expression between days 10-12 with moderate levels from day 13 until birth
+In the testis, expression is detected at 4 days postpartum (dpp) with a peak between days 10 and 14. Levels decrease by 18 dpp with a further decrease in the adult
+Expressed during embryogenesis and larvae
+Accumulates in meristematic tissues such as shoot apex and root tips, young leaf veins, stamens and stigmas of flowers, and abscission layers of young siliques. In young seedlings, present in root tips and junctions of roots and hypocotyls. Highest levels are reached in ten days old seedlings. In adult plants, confined to vasculature and hydathodes in leaves, and meristems. Also observed in floral developing organs
+Expressed in immature oocytes. Expressed at constant levels during meiosis and early embryonic cycles (at protein level)
+Developmentally regulated in a pattern coincident with active synaptogenesis and synaptic maturation
+Detected at low levels in developing testis at 5 and 10 days after birth. Highly expressed in testis 15 and 20 days after birth. Highly expressed in pachytene, diplotene and meiotically dividing spermatocytes and in early round spermatids
+In germinating seeds, first detected at about 48 h after imbibition. In young seedlings grown in continuous light, present in the root/shoot transition zone, in the apex, and in the apical region of the cotyledons. Later observed in lateral root primordia and in emerging lateral roots, particularly in the root tips, as well as in the shoot apex and in the new leaves, especially in the apical and lateral hydathodes. In adult plants, accumulates in lateral root tips, lateral root primordia, and axillary shoot primordia. In flowers, expressed in the style and stigmatic surface of the pistil and in the receptacle (base) of the flower throughout the development of the pistil until anthesis and later in the silique. Fades out after fertilization
+During early embryo development, its expression is restricted to the 4-cell to 8-cell stage of the preimplantation embryo
+Expressed in the somatic gonad from the L3 stage of larval development to adulthood
+Expression stimulated at early developmental stages, before aggregation
+Present in etiolated cotyledons; level increased during greening
+Expressed specifically in presomitic paraxial mesoderm and its immediate presumptive progenitor cells and sharply down-regulated in presumptive somites. Expression is first detected at gastrulation. Expressed throughout development until the tadpole stage. Expression is predominantly localized in ventrolateral mesoderm but is absent from dorsal mesoderm in gastrulae. In tailbud stage embryos, expression is still detected and is localized to the most caudal (unsegmented) paraxial mesoderm. At the tadpole stage, expression remains in the tailbud
+Expressed in shoots 10 days after seeding
+Highly expressed in the embryos at 12 hpf and 1 dpf and expressed at high level at 3 dpf and 4 dpf, but at a lower level at 5 dpf. At 2 dpf, ubiquitously expressed, but enriched in the mid and hindbrain boundary. Through 3-5 dpf, expressed mainly in the gut, liver, pancreas and pharynx
+First expressed in the apical cell after the first asymmetric division of the zygote. Expressed in all proembryo cells until the eight-cell stage, and then restricted to the protoderm in the 16-cell proembryo. Not detected in the torpedo stage, but reappeared later in the L1 layer of the shoot apical meristem in the mature embryo. After germination, the L1 layer-specific expression pattern is maintained in the vegetative shoot apical meristem, inflorescence, floral meristems, and the young floral organ primordia. Finally, expressed in the protoderm of the ovule primordia and integuments and gradually restricted to the endothelium surrounding the embryo sac
+First detected in presumptive postmitotic neurons in the developing neural tube at embryonic day 9
+Increased expression during grain maturation
+Localized in the flagella of elongating spermatids from developmental step 15 to maturity
+In embryos, predominantly expressed in neural tissues (PubMed:15640247). Expressed throughout inner ear development: expressed in the neuroepithelium, head mesenchyme and the cochlear floor (PubMed:21246654)
+Not detected at 8.5 dpc. Expressed from 9.5 dpc throughout development and into adulthood (at protein level)
+Mainly observed at earlier stages of panicle development (PubMed:16240176). Up-regulated in young spikelet of primary branch-differentiating stage and down-regulated in young spikelet of pistil and stamen-differentiating stage (PubMed:16753815). Accumulates in differentiating calli (PubMed:16753815)
+In anthers, predominantly detected in meiocytes and tapetal cells from stage 5 to early stage 7, with highest levels at stage 6, the time of male meiosis. In ovules, present in female meiocytes and embryo sacs
+Expressed in embryonic stem (ES) cells and in inner cell mass (ICM) of the blastocyst. At 8.25 dpc it is expressed in both the neuroectoderm and mesenchyme of the neural folds but not in extra-embryonic membranes (PubMed:31006510)
+Expressed in young seedlings, especially at the tip of the growing shoot meristems. Later observed in roots and in aerial parts. Weakly expressed in leaves with local higher levels in the trichomes, hydathodes and in cotyledon veins. Present at low levels in flowers with higher accumulation in cells at organ-stem junctions, as well as in the septum and the funiculi of the developing siliques. Also observed in a diffuse pattern, appearing as patches along the stem but also concentrated at the peduncle
+Expressed in the ectoderm of embryos (at protein level)
+Expressed in the developing embryo
+Expressed in both vegetative and differentiating cells, with a higher level in vegetative cells
+In retinal pigment epithelium (RPE1) cell line, after 24 hours of serum starvation to stimulate primary cilium production, present at the mother and daughter basal bodies. At early time points of ciliogenesis, not detected in the axoneme. At later time points, expressed along the axoneme, with increasing levels as maturation of the cilium proceeds
+Expressed primarily during seed development
+Detected at 11.5-day fetal livers (at protein level). Isoform 2 detected earlier at 8.5-day embryo
+In roots, expressed only in the quiescent center (QC) and the columella stem cells (CC) initials (PubMed:23370719). Slightly observed in additional underlying CCs and in the vascular initials above the QC (PubMed:23370719). Induced early during lateral root formation (PubMed:23370719)
+Expressed at larval, nymphal, and adult stages of fed and unfed ticks, but not expressed at the egg stage. Has the highest expression in the rapid blood meal sucking period (3-4 days after feeding) of all the stages
+Hardly detectable at embryonic day (E) 14, then increases until postnatal day 17 and remains detectable in the adult (PubMed:12812753). Expressed as early as 11.5 dpc in the maxillary process until 16.5 dpc when is expressed in the newly formed mandible. At 14.5 dpc is detected in smooth muscle cells of the stomach and intestine and at 15.5, in the periosteum of the ribs. At 16.5 dpc the expression is restricted to mandible, palate and teeth (PubMed:14709716). During endochondral bone formation, first expressed at 13.5 dpc in the perichondrium. At E 16.5, detected in perichondrium and periosteum (PubMed:17395156)
+First expressed around the day 7 embryo
+When eel matures sexually and migrates back to deep sea breeding grounds the visual pigments in its rod photoreceptors change from being maximally sensitive to green light to being maximally sensitive to blue light. In part, this change in sensitivity is due to a change in the opsin component of the visual pigment molecule; this blue sensitive rhodopsin is expressed during life in bluer oceanic waters
+This protein is expressed at all stages during development but is expressed maximally during the aggregation and culmination periods
+Early expression is detected in the inflorescence apex of developing flowers and also in the ovule primordium and the integuments
+Accumulates transiently in the early stages of seed maturation (PubMed:9870704). Observed in maturating caryopsis 1 week after flowering (DAF) (PubMed:16087344)
+Expressed during the asexual blood stage including in trophozoites and schizonts (at protein level)
+In liver; activity 6 fold higher in females than in males
+The levels are low in green fruits but accumulate with color change occurring during ripening, reaching maximum levels in fully colored fruit. The levels increase during flower development and show highest levels in flowers at anthesis
+Expressed throughout embryogenesis (at protein level)
+Throughout embryonic development
+Initially expressed ubiquitously in the early embryo and later throughout the developing ectoderm but becomes highly restricted to the developing CNS and PNS. Peak expression seen at the blastoderm stage (2-4 hours) (at protein level)
+In neonatal stomach, highly expressed for the first two weeks after birth, with rapidly decreasing expression after 17.5 days. In placenta, detected from 11.5 dpc until term
+Expressed at very early embryogenic stage and in the pupal stage
+Isoform 1 is detected in the earliest born neurons. At 9.5 dpc it is detected in the ventrolateral part of the spinal cord, which later become motor neurons and is also detected in the dispersed cells of the alar plate interneurons. During spinal cord development, the expression is highest in the latest born neurons (the subventricular zone). Detected in the early differentiated neurons within the neuroepithelium and the neural crest cells at 9.5 dpc. At 12.5 dpc, detected in the differentiated neurons within the forebrain, midbrain, and hindbrain. In these neurons, the expression level is highest in the latest born neurons and is also detected in the differentiated neurons of the sensory organs and the peripheral ganglia
+Expressed maternally from early cleavage stages until the shield stage. Expressed zygotically in the polster at the bud stage. Expressed in the midbrain-hindbrain boundary (MHB) at 12 hours post-fertilization (hpf). Expressed in the tail bud and the mesenchymal cells of the caudal fin primordia at 26 hpf
+In 10.5 dpc embryo somites is expressed in a ventral cell layer (myotome)
+Down-regulated in skeletal muscles atrophies, including atrophies linked to aging and denervation
+Expressed with a peak at the early globular stage and until the late heart-torpedo stage of embryo development
+Expressed at fertilization and up to 2 hours post-fertilization (hpf), expression then declines to low levels at 4 hpf before increasing at 6 hpf onwards until 96 hpf (PubMed:22235774). Expressed in the atrium, ventricle, and both the inflow and outflow tracts at 48 hours post-fertilization (PubMed:17186466)
+Start of expression coincides with the onset of axonogenesis
+Low expression in developing seedlings
+From week 1 to 7, the number of cells expressing GNAT3 in single taste buds increases within fungiform papilla; by week 7, the number reached the value found in adults. Expressed in cell bodies and axons of facial motor neurons at 10.5 dpc
+Relatively constant levels in mature roots (PubMed:24569845). Rapid decrease in roots and leaves from the leaf opened to the green fruit stage (PubMed:30577538). At the leaf opened stage, accumulates mostly in roots (PubMed:30577538)
+Expressed during leaves senescence, seeds development, and siliques maturation
+Detected in embryonic intermediate cell mass (site of hematopoiesis), liver and heart
+First expressed in intestinal precursor cells during embryogenesis. Expressed in intestinal and neuronal cells in newly hatched larvae at the L1 stage of development
+Expressed at maximal levels after first day of cell growth
+Expressed from 10.5 hours post-fertilization (hpf). During embryogenesis, expression is restricted to developing somites and heart
+Expressed in embryos (at protein level) (PubMed:11054539). Expressed at various developmental stages (PubMed:11054539)
+Detected in prospermatogonia in embryos after 14 days of development and until 8 days after birth. Not detectable in spermatogonia from over 10 day old animals. Highly expressed in spermatocytes and spermatids from 12-28 day old animals, but not in spermatogonia. Detected in embryonic ovary after 14 days of development and in newly born animals. Expression is much reduced in ovary from 4 day old animals, and not detectable thereafter. Not detectable in oocytes that are surrounded by follicular cells
+In the tailbud stage, it is expressed in the olfactory bulbs, pineal complex and along the neural tube according to an antero-posterior gradient showing a gap at the midbrain-hindbrain boundary. At tadpole stage, it is expressed in the differentiating retina, in the neuronal fibers of the outer and inner plexiform layers, while its expression in the pineal complex becomes restricted to the photosensitive frontal organ
+Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum
+At 16.5 dpc, present in periosteum of ribs. At P0, present in tendons connecting the scapula and humerus to muscles (at protein level)
+Expressed both maternally and zygotically. Expression increases markedly at the mid-blastula transition (MBT) and peaks at the onset of gastrulation before declining rapidly during the gastrula stages. Another decrease in expression levels occurs towards the end of the neurula stages, although expression is retained into the late tailbud stages
+At the end of embryogenesis, accumulates in the gut and muscles
+Expressed in lungs of 15 days old fetuses followed by a modest peak at day 17, thereafter decreasing in adult lungs
+Maternal transcripts detected in eggs. Uniform expression across the entire animal hemisphere and marginal zone of the early gastrula. At tailbud stage, expressed in the developing tail, anterior brain, eye and heart
+Expressed at low levels in brains of 1-day old animals but increase to adult levels from 7-day old animals and remain at that level in adults
+During tissue displacement in the early bud, transiently present ubiquitously. A few hours later, coincident with the acquisition of organiser properties by the bud tip, a few cells in the apical tip express the gene strongly. About 20 hours after the onset of evagination, expression is switched on in a ring of cells surrounding the bud base, and shortly thereafter vanishes from the apical expression zone. The basal ring persists in the parent during tissue contraction and foot formation in the young polyp, until several hours after bud detachment. Inhibition of bud detachment by head regeneration results in severe distortion, disruption or even complete loss of the well-defined ring-like expression zone
+Expression is observed in the cephalic ganglion and mesenchymal space in intact planarians. In regenerating planarians, accumulation was observed in the blastema and in fragments regenerating either a pharynx or a brain
+Not expressed during gastrulation, and shortly after gastrulation found in the cells of the ventral fore-brain rudiment, presumptive precursor cells of the olfactory placodes, overlapping subsets of cells in the auditory vesicle, cells of the median fin fold, and cells of the visceral arches and their primordia
+Expressed 3 day after germination (DAG) in first rosette leaf primordia around the veins in the apical part of the leaf and close to the midvein in the basal part of the leaf. At later stage, expressed in new forming veins, and veins and fascicular cambium of mature leaves
+Present in fully grown and progesterone-matured oocytes. The level change vera little even after zygotic gene transcription begins following the mid-blastula transition. Do not increase in abundance in the gastrula, neurula, tailbud, or tadpole embryo
+First detected at the eight-cell stage. Expressed in eight-cell embryo, blastocyst, 6.5-day whole embryo, 7.5-day primitive streak, 11.5-day limb bud and in 13.5-day whole embryo
+Expressed when organs wither and separate from the fruit or the green silique. Expressed in unpollinated, degrading ovules (PubMed:21632425). Expressed specifically in the tapetum from stages 5 to 11 of anther development (PubMed:25035401)
+In the developing embryo, expressed mainly in differentiating and developing somites and is associated with myotomal somite lineages
+Increases rapidly between 1 and 3 days after seed germination
+Expressed during spore germination and growth
+Expressed at high levels only in the later stages of development
+Expressed in scolex and bladder wall of metacestode larval stage. Expressed in adults
+Expressed both maternally and zygotically. Shows biphasic expression during early development. Expressed ubiquitously in fertilized eggs and throughout the midblastula transition. Expression then decreases at mid-gastrulation. Shortly after gastrulation, expression is seen throughout the dorsal side of the embryo with expression strongest in the anterior and absent ventrally. Expression increases along the dorsal midline at early neurulation and is seen in the head region as neurulation progresses, particularly in the area of the cement gland primordium. Also present in the anterior mesoderm but is absent from the neural tube and the most ventral part of the embryo. Remains expressed throughout early embryogenesis. By the tailbud stages, expression is anterior, in the head and the most rostral part of the neural tube
+Expressed throughout the developmental stages with a 2-fold increase in late larval (L4) stage
+Before pollination, expressed in stamens and carpels. After pollination, observed in the veins of petals, sepals, and filaments. Present in seeds at the embryo globular stage, both in the embryo and the endosperm. Later, at the embryo heart stage, not detected in the embryo, but strongly expressed in the maternal chalazal tissue and present in the endosperm
+In day 16 embryo highest levels in forebrain, thymus, salivary gland and cartilage
+Expressed in embryo during embryogenesis, first throughoutthe embryo, but later basally localized at the heart stage (PubMed:12172019, PubMed:25564655). Also present in free nuclear endosperm, but disappears once endosperm cellularization begins (PubMed:12172019). Observed in the stem cell niche and the provascular tissue of mature roots (PubMed:25564655)
+Widely expressed in the developing embryo from 9.5 dpc to 12.5 dpc (PubMed:8441686, PubMed:18505825, PubMed:18403418, PubMed:20596238). Expressed throughout the central and peripheral nervous system, as well as the mesenchyme of many developing organs between 12.5 dpc and 14.5 dpc (PubMed:18403418). Strongly expressed in the lens of the eye, developing cerebral cortex, the dorsal cortical plate, thalamus, hippocampus and cerebellar cortex in the brain at 14.5 dpc (PubMed:18505825). Expressed in skin, spinal cord, lung, liver, intestine, kidney, heart, muscle, cartilage from 14.5 dpc to 18.5 dpc (PubMed:18505825). Abundantly expressed in the brain, heart and lung, with low expression in the liver, pancreas, and small intestine at postnatal day 2 (PubMed:18403418)
+Expressed during embryogenesis between 8.5 and 18.5 dpc
+Expressed from the 28 cell stage of embryogenesis in hypodermal and muscle precursor cells (at protein level) (PubMed:9224715). Expressed from the 20-30 cell stage of embryogenesis onwards (PubMed:16303852). At the beginning of the comma stage, expression decreases in the dorsal and ventral hypodermis, but remains high in the seam cells until the pretzel stage of embryogenesis (PubMed:16303852). Expressed in neuronal cells of the retrovesicular ganglion during the threefold stage of embryogenesis (PubMed:16303852). Expressed highly in seam cells and retrovesicular ganglion and ventral cord neuronal cells from the L1 stage of larval development to adult (PubMed:16303852). Expressed in the sperm-producing germ line in spermatogenesis during the L4 stage of larval development (PubMed:19591818)
+In the developing brain, expression is detected at embryonic day (E) 10 in the neuroepithelium, and subsequently in the ventricular zones of the cerebral cortex in the 12 dpc embryo. Strong expression is observed in the preplate in the cerebral cortex from this stage onward. High levels of expression continue to be detected in the cortical plate and subventricular zone of the neocortex, hippocampus, and parts of the amygdala, but not in the thalamus or striatum. In the developing cerebral cortex, it is expressed both in postmitotic glutamatergic projection neurons and in their progenitor cells, but not in GABAergic interneurons. Also expressed in the adult neocortex, hippocampus, parts of the amygdala and granule cells in the cerebellum
+At postnatal day 3 (P3), the expression is restricted to cells in the hindbrain and cerebellum, subsequently spreading rostrally throughout the white matter tracks over the first 2 weeks postnatal, mirroring the expression of Plp1
+In flowers, expressed in the vasculature of petals, stamen filaments, anther microsporangia, and papillar cells of the stigma and style. In siliques, accumulates in the stigmatic region, replum, funiculus, and valve
+Expression increases during senescence with the highest levels in fully senescent leaves
+Expression increases during meiosis
+Accumulates progressively in panicles. Present at low levels in developing seeds, with a progressive decrease during development (PubMed:20713616). In spikelets, fades out progressively after anthesis (PubMed:25817414)
+During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve
+Expressed both maternally and zygotically, highest expression level is during embryogenesis
+Expressed both maternally and zygotically. Significantly expressed after the onset of gastrulation and throughout embryonic development
+Up-regulated during late spermiogenesis, when the flagellum is being assembled
+Strongly expressed in early embryos and endosperm, but very weakly in globular embryos and further embryo developmental stages
+Expressed in all cells in pregastrulation stages. During gastrulation is differentially expressed, accumulating predominantly in the prechordal mesoderm and notochord. At the end of gastrulation, expressed along the anterior-posterior axis including the developing neural plate and differentiating mesoderm. Also present in the developing brain and head regions
+Strongly expressed in the developing nervous system at 18.5 dpc. Present in brain, heart, lung, kidney and thymus at 18.5 dpc (at protein level)
+First expressed at blastoderm stage and later in restricted aeras of the embryonic nervous system as well as in the developing trachea
+Expressed both maternally and zygotically. Highest zygotic expression found in adult females and pupae
+Highest levels are found during early embryonic development until approximately 18 hours and during pupariation
+Detected in cortical plate, trigeminal ganglion, dorsal root ganglia and the spinal cord at embryonic stage 14.5 dpc. Widely expressed in brain at postnatal day 7 including cortex, olfactory bulb, hippocampus and cerebellum. Expressed throughout layers II-VI of the cortex. In the olfactory bulb, has strongest expression in glomerular and mitral cell layers. In hippocampus, localizes to CA1, CA2, CA3 and dentate gyrus regions. In cerebellum, mainly expressed in the internal granule cell layer and the Purkinje cell layer
+Expressed during procyclic stages
+Developmentally regulated with highest levels during growth and early development
+The different late H2A and H2B mRNAs are present in as few as 200 copies in the egg and each accumulate to 3-5 x 100000 molecules in the gastrula embryo
+Expressed in the vegetative cell during the later stages of pollen development, mostly in tricellular pollen grains, and, to a lower extent, in bicellular pollen grains
+Widely detected at one day post-fertilization (dpf) and continuously expressed in the brain through development
+Expressed during meiosis (at protein level)
+Ubiquitously expressed in embryos until eight hours after fertilization. Detected throughout the embryo, but particularly in the cephalic region, at 10 to 24 hours after fertilization. Detected in retina, tegmentum and myencephalon at 38 and 48 hours after fertilization
+Expressed in the embryo at least from 10 dpc until birth
+Highly expressed during stationary phase, down-regulated during logarithmic phase of growth
+Expressed in fetal kidney and fetal lung
+Expressed in fetal skin
+Postimplantation. Expression is observed in undifferentiated mesoderm and in tissues undergoing EMTs, namely the precursors of the neural crest cells and the primitive streak
+Detected only in the generative cell and the sperm-cell of late bicellular and tricellular pollen. Not detected in pollen vegetative cells. Replication-independent expression
+Cell cycle-regulated. Highest level during S phase
+Expressed in somatic gonad precursors Z1 and Z4 in the gonad primordium and later in distal tip cells during the larval stages
+Expressed in both the promastigote and the amastigote forms
+Expressed in the myotome of somites from 9.5 dpc. In muscular tissues, expression is transient and is confined to a few sites of the developing embryo, such as limbs, tongue, and smooth muscle layers of stomach and esophagus. Also detected in skin at 16.5 dpc and in cerebral cortex and hippocampus of the newborn brain. In adult, expression is only observed in cerebrum, cerebellum, eyes, and testis. In CNS, expression gradually increases following birth. Also expressed in embryonic fibroblasts and to a lesser extent in adult fibroblasts
+In seedlings, confined to hypocotyls in darkness, but expressed in all tissues except in hypocotyls in light. In flowers, present in all organs except petals
+Expressed in testis from 3 weeks of age onwards, reaching maximum levels by 4 to 5 weeks of age
+POI activity increases throughout pupariation, and is highest in final instar pupae. No activity in newly emerged adults
+First detected at around 8 hours post-fertilization (hpf) within the prospective midbrain-hindbrain boundary (MHB). By 10 hpf, expressed in two stripes that converge at the dorsal midline. During somitogenesis, this expression domain extends to the prospective epiphysis and the dorsal midline of the hindbrain; unlike wnt1, wnt10b is detected in the prospective cerebellum. The hindbrain domain bifurcates along the midline to form two dorsolateral columns with transverse bands of up-regulation at rhombomere boundaries; these are refined into stripes which are maintained at least until at least 48 hpf. At 30 hpf, expressed in the epiphysis, the dorsal midline of the optic tectum, the anterior half of the MHB constriction and in the hindbrain walls
+In the seminal vesicle, not expressed during prepubertal stages; expression coincides with maturation
+On days 1-4 of pregnancy, ERBB2 is detected primarily in epithelial cells, the day 1 uterus showing the highest accumulation. On day 5, the epithelium and the decidualizing stromal cells around the implanting blastocyst exhibit accumulation of this receptor. On days 6-8, the expression persists in the epithelium at both the implantation and interimplantation sites in addition to modest levels in the secondary decidual zone. On days 7 and 8, accumulation is also prominent in the trophoblastic giant cells
+Expressed in the embryos, endosperm, and outer teguments of the seed throughout seed development
+Accumulates in young fruitlets but disappears progressively one month after fecondation
+Expressed in primitive compartments of umbilical vein cord
+Is initially detected at the late tail bud stage when the liver appears
+Increases during pregnancy (2.2-fold at 4 days) and lactation (1.5-fold at 21 days). Decreases in the early phases of involution (33%, 21%, and 45% on days 1, 2, and 3 respectively)
+Not detected in the thymus before birth
+Expressed in the hermaphrodite-specific motor neuron (HSN) / phasmid sensory neuron B (PHB) precursor, and the phasmid sensory neuron A (PHA) in the tail at ~400 minutes embryogenesis (at protein level) (PubMed:10049362). Continues to be expressed in PHA and PHB neurons of L1 larvae (PubMed:10049362). Expressed in the HSN before and during HSN migration from the tail to the gonad primordium of the embryo and down-regulated after migration (at protein level) (PubMed:10049362). Expressed in the pre-anchor cell (AC)/pre-ventral uterine (VU) cells at early L2 and maintained in their 37 descendants at early L4 (PubMed:17215301, PubMed:32203506)
+Expressed in the ventral uterine (VU) cells of mid L2 larvae (Pn.p stage) and then in the anchor cell (AC) beginning in mid L3 larvae (PubMed:17573066, PubMed:32203506). Expression increases during AC invasion (PubMed:17573066)
+Expressed, earlier than isoform a, in the anchor cell (AC) at the Pn.p stage in mid L2 larvae (PubMed:17573066). Expression decreases during AC invasion (PubMed:17573066)
+Expressed zygotically. Expression begins in the blastula stage. Levels increase throughout gastrulation before decreasing at the tadpole stage
+Expression increases rapidly in whole body during embryonic and early larval development. However, the rate of expression decreases to plateau during yolk sac absorption. Expression not detected in fertilized oocytes and in prehatching larvae with eye spots. First detected in post-hatching larvae and peaks soon thereafter with the appearance of muscle activity coinciding with early myogenesis
+Expression is constant during growth, decreases during sporulation and is induced approximately 15 min into spore germination. Present in the inner forespore membrane of the dormant spore (PubMed:3080407)
+In 3rd instar larvae, expressed in various tissues including the brain, salivary glands, fat body, proventriculus, hind gut, muscle, Malpighian tubules and tracheal tubes. Relatively low levels of expression in the brain compared to expression levels in the salivary gland, fat body and gut
+Not detected in adult tissues. Expressed at low levels in early embryogenesis
+Constitutive expression with an increase during flowering
+Expressed both maternally and zygotically. Maternal expression decreases during early cleavage stages becoming absent during gastrulation. Zygotic expression begins during neurulation with expression levels increasing as development progresses
+The differential expression of MBP isoforms is developmentally regulated. Isoform 2 and isoform 3 are first expressed during embryonic stages (as early as at embryonic day 11.5), expression of isoform 1 is turned on shortly after birth. Expression of the isoforms missing the 134 first amino acids occurs later, presumably as the oligodendrocytes approach their terminally differentiated state
+High expression 7 days after pollination (DAP), gradually declines after 15 DAP and becomes undetectable by 29 DAP
+Abundant expression in growing oocytes, levels decline in primary and secondary oocytes, and degradation appears to be complete by the mid-late two-cell stage
+Expressed from embryogenesis to adulthood (PubMed:21979920). First expressed in comma stage embryos (PubMed:21979920). Highly expressed in L4 larvae and adults (PubMed:21979920)
+Detected after completion of the gastrula period. Maximal expression after 1 to 2 days of development
+Expression, first detected at 5 weeks of age, increases up to 15 weeks and remains high for at least 63 weeks
+Widely distributed (PubMed:11807098). Expressed at 12.5 dpc in the ventricular and subventricular zones. Highly expressed at 16 dpc in blood vessels, renal cortices, respiratory and alimentary tracts, olfactory epithelium, presumed isles of hematopoiesis within the liver; lower expression in the cerebral cortex and choroid plexus (PubMed:11807098). In 12 dpc embryos, expressed in DRG neurons, motoneurons and the neuroepithelial cell layer around the central canal in spinal cord (PubMed:25358863)
+Expressed as early as 10 dpc in developing brain and reaches maximal levels at 18 dpc
+Expressed from larval stage L1 to adult stages but not during embryonic development
+Expressed at larval L1 and L3 stages and in adulthood
+Present in fruit throughout the development, but fades out during ripening
+Expression peaks at 10.5 dpc, then declines. Expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, and in the developing central nervous system
+Detected in developing leaves during proliferation stage (9-day-old plants) and expression rapidly declines in leaves of 13 till 21-day-old plants. Also expressed during stomatal cell differentiation
+Probably maternally supplied, the zygotic expression becomes significative at shield stage (6 hpf) and then decreases after 7.5 hpf but is still detected at 24 hpf
+Expressed throughout embryonic development. Expressed in the presomitic mesoderm (PSM) and the neural folds along the entire rostrocaudal axis at 8.5 days post-coitum (dpc). Expressed in the forelimb buds, the branchial arches, and at the anterior and posterior of each somite boundary at 9.5 dpc. Expressed in the neural tube, the PSM, somites and the dorsal limb bud mesenchyme at 10.5 dpc. At 11.5 dpc three distinct phases of expression can be seen; expression is initially low in the tailbud, rises in the PSM and then shifts anteriorly. These oscillations require the activity of HES7
+Expressed in endothelial cells of allantois/umbilical vessels at 8.5 dpc (at protein level). Increases moderately during pregnancy (maximum 2.7-fold at 19 days), and increases further during lactation (maximum 3.7-fold increase on day 7)
+Expressed throughout embryonic development and in adults. During embryogenesis, expressed from the 2-cell stage and persists throughout development in nucleoli containing cells
+Expressed in the developing kidney at stages 26-29 and 33-36, and in the branchial arches at stage 33-36
+Expressed in epidermal cells as early as the 50-100 cell stage of embryogenesis and in intestinal cells at the 4E stage (PubMed:17826759). Expressed in non-migratory, syncytial epidermis at larval stage L1 (PubMed:17826759)
+In very young seedlings, confined to the tips of the cotyledons. Later expressed in the cotyledon vasculature and petiole. Present in the tip of emerging leaves. In mature leaves, observed in the vasculature
+Expressed from early in development through adulthood
+Expressed in the developing heart at 13.5 and 16.5 dpc, during the transition from spongy to compact myocardium (PubMed:17198697). Not detected in the skeletal system at 11 and 13.5 dpc (PubMed:10620601)
+First detected at low levels in embryonic liver after 12.5 days of embryonic development. Highly expressed in liver and kidney after 18.5 days of embryonic development. Expressed at high levels in liver and kidney after birth and in adults. Age-dependent expression in mouse skeletal muscles; protein expression in skeletal muscles increased 5 days after birth, and remained stable until 10 weeks, then slightly decreased at 26 weeks and was significantly lower at 51 weeks (PubMed:33826201)
+Detected in developing branch and spikelet meristems at very early stages of inflorescence formation, and is maintained uniformly in the spikelet meristems until floral organs initiation. Present in some floral organ primordia
+Expressed in the prothoracic gland in 4th and 5th instar stage larvae, and P0 stage pupae. Also detected at lower level in testes and ovaries of 5th instar larvae
+Expressed in the larva, but not in the embryo
+Isoform PINA is expressed during daytime in embryonic pineal (postnatal day 2 and 7) and embryonic retinal pigment epithelium (embryonic day 14.5 and postnatal day 16). Daytime expression disappears in pineal at postnatal day 16 and in adult retina
+Detected at low levels in newly hatched larvae with higher levels in the fifth instar larvae which continue into the early and middle pupal stages. Expression then decreases by 6-day-old pupal stage and reduces further in the adult stage (at protein level). Expressed in the embryonic, larval and pupal-adult development stages. Detected in male embryos 6 days after oviposition with expression in female embryos starting later around day 8
+Expressed during early embryonic development from the two cell to blastocyst stages (PubMed:28663440). Expressed in populations of the definitive endoderm from 7 to 8.5 dpc (PubMed:20153842)
+Highly expressed in seedling cotyledons and shoot apices in young and mature plants
+Accumulates early in cone development and stays at high levels throughout cone formation
+Detected at embryonic stages 13-14 (PubMed:22084112). During embryonic and larval development, expressed in the ventral nerve cord (VNC) in a subset of peripheral nervous system neurons including C4da (at protein level) (PubMed:22084112, PubMed:21338947, PubMed:24746793)
+In the embryo, expressed at highest levels at day 10 with levels decreasing during further development
+Transcribed during the late vegetative and early stationary phases
+At stages 8 to 9, expressed in the whole lateral plate mesoderm and precardiogenic mesoderm. At stage 10, expressed throughout the cardiac tube and the sinus venosus. By stage 15, expressed homogeneously in the various region of the heart, including the atria, future left ventricle, bulbus cordis and truncus arteriosus, and in the forming branchial arches. Expression persists through stage 20, but decreases thereafter. In the developing limbs, from the initiation of the buds (stages 16 to 17), expression is down-regulated at the anterior of the limb buds so that a gradient expression along the anterior-posterior axis of the bud is established with higher expression at the posterior border. At later stages, expression is restricted to the posterior border of the zeugopod and to the posterior autopod. In the autopod, dynamic expression of HAND2 affects the interdigital regions, the lateral borders of the digits and eventually the developing ventral tendons
+Up-regulated during the early anagen phase of the hair cycle. Thereafter, levels decrease and are very low at telogen phase
+Detected throughout embryogenesis
+Isoform 3 expression is maintained throughout cerebellar development, while isoform 2 expression gradually decrease following the first postnatal week
+Is first detected at the end of the late streak stage in presumptive lateral and extraembryonic mesoderm. During early neurogenesis, it is detected solely in lateral mesoderm. By late neurogenesis and through mid-gestation, it is found in a restricted region of presumed trunk neural crest and the dermatome
+Mainly present in proliferating tissues (PubMed:21558309). In flowers, expressed in stamens, carpels, petals, sepals and pedicels (PubMed:23893219). Accumulates progressively in leaves during aging (PubMed:23893219)
+Expressed at very low levels in quiescent cells. When cells are stimulated to reenter growth, they undergo 2 waves of expression, the first one peaks 7.5 minutes following FBS induction. At this stage, the protein is localized endoplasmic reticulum. The second wave of expression occurs at about 20 minutes after induction and peaks at 1 hour. At this stage, the protein becomes nuclear
+During embryonic development, it is expressed in regions that participate in Hedgehog signaling. First expressed during gastrulation stages in the ventral node. At 9.5 dpc, expressed in the gut endoderm, limb buds, notochord, somites, neural tube and floorplate
+Expressed both maternally and zygotically. At early blastoderm stage, forms a symmetrical concentration gradient at the poles on the surface of the devitellinized embryo
+Gastrulating embryo
+Expressed during early development
+At E(15), found in the perichondrium of the developing bone. At E(14) detected in the lung parenchyma
+Expression first seen at the 8E cell stage in the embryonic intestine. Expression continues to and includes adulthood. Beginning at the comma stage, additional expression is seen in the head and possibly in the hypodermis. By the twofold stage and continuing into adulthood, expression becomes increasingly widespread, with strong staining in the intestine, pharynx, hypodermis, body wall muscle, tail, and unidentified head neurons
+Expression is lower in total embryos and in adult tissues
+Slightly expressed in flower petals
+In 9 dpc embryos, strongly expressed in the craniofacial region, the branchial arches and in limb buds. Also expressed in brain and along the neural tube. At 9 dpc and 10 dpc, no expression is detected in the heart but at later stages expressed weakly in the ventricle. At 11 dpc and 12 dpc, highly expressed in the neural tube, limb bud, dorsal trunk and tail mesenchyme. In the brain of 13 dpc embryos, highly expressed in the cortex and the dorsal spinal cord and weakly in midbrain
+During ontogeny TDT appears in significant amounts in the thymus of tadpoles at metamorphic climax but little in the earlier midlarval stages
+Activity found in solid culture only. Increases at the initial growth stage and decreases in the late growth stage
+Expressed in the nasal placodes and optic vesicles at day 9.5 dpc and in the nasal epithelium at 12.5 dpc (PubMed:28067911). Expressed in the nasal cavity in 14.5 dpc animals (PubMed:28067911)
+Somites and placodal expression appears at stage 9. At this stage, more obvious expression is detected in the neural tube (midbrain and rostral hindbrain), and persists through about stage 15. Strongly expressed in the ectoderm and around the otic placodes at stage 12. At stage 16, otic expression declines, expression in epibranchial placodes begins and peaks at stage 20. Expression in the lens of the eye is first seen at about stage 15, more evident at stage 16. At stage 17, seen in the ectoderm and mesenchyme of the limb primordia. Detected at stage 20 in the lip of the optic cup, in the mesenchyme surrounding the eye, in the ectoderm overlying the lens and in the ectoderm caudal and ventral of the olfactory placodes. From stages 20-30, expressed in cartilage and in the dermomyotomes and migrating sclerotomal cells forming vertebrae
+In young seedlings, expressed in hypocotyls, hypocotyl/root junctions and roots, especially in vascular tissue (e.g. xylem and metaxylem) (PubMed:31862580). Observed in shoot apex, associated with stipules (PubMed:31862580)
+Expressed in anterior neural plate
+During early phases of embryogenesis, expressed in all the cells of the embryo proper and the suspensor until the 32-cell embryo stage. At the heart stage, expression completely disappears in the suspensor, but remains in the embryo proper. After germination, expressed in shoot apical meristem (SAM), leaf primordia, root apical meristem (RAM), and lateral root primordia
+At stage 22, expressed in blood islands, somites, eyes, trunk neural crest, mandibular crest segment, hyoid crest segment and branchial crest segment. At stage 32, expressed in otic vesicle, pronephros, forebraiin, midbrain, hindbrain, branchial arch, eyes, lens, spinal cord and notochord
+Expressed exclusively in the developing heart and eye. Expression begins within a subset of cardioblasts at neurula stages and continues within the heart during morphogenesis at later tadpole stages. Within the heart tube, expressed in all but the most anterior domain, the bulbus cordis
+Expressed from embryonic day 16. Expressed throughout embryonic development, in neonate and in adult
+Expressed in neurons after maturation
+Expressed in seam cells with temporal changes in expression level; undetectable in L1 and L2 larval stages, then expressed at the L3 stage, declining at the late L4 stage and expressed only weakly in young adults (PubMed:19500563). Expressed in the vulval precursor cells (VPCs) (PubMed:15020414)
+Accumulates in a circadian fashion, peaking at circadian time (CT) 15-18
+First accumulates at 8 hours of development and is maintained in both prespore and prestalk cells until culmination when it is found only is stalk cells. During the mound stage, equally abundant in all cells, whereas during the finger/migrating slug stage, expression is somewhat higher in the anterior prestalk region. During culmination predominantly seen in the descending stalk tube
+In spleen mRNA levels are higher in adult than in fetal tissue
+Expression in liver is reduced by 70% in 2 years old rats compare to 3 weeks old
+Expressed in a series of equally spaced stripes covering the trunk anlagen in the blastoderm embryo. By late blastoderm, expressed in the head lobes
+Expressed along a developmental gradient in the inflorescence stem, with higher levels in olders organs and low levels in young tissues
+Increases in amount during brain development coincident with synaptogenesis
+Expressed in the shoot apical meristem (SAM) and young flower buds. In mature flowers, restricted to the reproductive organs stamens and carpels. In the stamen, accumulates in male meiocytes and in tapetal cells, as well as in mature pollen grains. In the carpel, present in developing ovules and in developing embryos
+First detected in the suspensor cells of octant-stage embryos, in the basal plasma membrane of the basal-most cell of the suspensor, which is in direct contact with maternal tissue. Expressed in the central domain protodermal cells when cotyledon primordia become recognizable. Later observed throughout the central domain and basal domain of the embryo proper, as well as the suspensor
+Expressed in the Y cell before transdifferentiation in the embryo and during redifferentiation into the PDA neuron in larval stages L2 and L3 but not in larval stage L1 (PubMed:25124442). Expression declines in the adult soma (PubMed:26212459)
+Ubiquitous during segmentation. Detected in otic vesicle and statoacoustic ganglion at later stages of development. At 24 hpf, detected in developing fast muscle throughout the trunk
+Expressed throughout development, levels increasing from embryo to pupa, then decreasing in adults with higher levels in adult males than females
+Expressed from one cell stage embryos
+Enzymatic activity is higher during the stationary vegetative phase and on the spores
+Strongly expressed in spermatogonia and primary spermatocytes. At later stages of maturation, expression gradually decreases and becomes undetectable in mature spermatids
+Not expressed in the embryo. Expressed in the kidney of newborns
+Expressed in male rats, but not in females
+Before anthesis, expressed in the vascular bundles of spikelets, stamens, pistils, and husk. After fertilization, expressed in the husk, spikelets, and pistil. From 3 to 10 days after anthesis, expressed in the dorsal vascular bundles of developing ovaries. At 15 days after anthesis, expressed in the embryo and dorsal vascular bundles. At 30 days after anthesis, expressed in the scutellum and endosperm
+Up-regulated in differentiating cultures of primary osteoblasts and down-regulated in late stage mineralizing cultures. In testis, expression is highest between stages I and VII when maturing spermatids remain buried within the Sertoli epithelium
+Isoforms 3 and 4 are first detected in testis from postnatal day 18 to adult
+Expressed at highest levels early in development
+Expressed in numerous fetal tissues
+Specifically expressed just prior to each larval molt (PubMed:11589574). Expression is restricted to the pharynx and specifically to the glandular cells g1 and g2 in the terminal bulb, the 3 m4 myo-epithelial cells in the metacorpus and the 3 m3 myo-epithelial cells in the procorpus (PubMed:16098962, PubMed:11589574). Not expressed in adults (PubMed:11589574)
+Low expression in the young panicle continues to decline as the organ mature
+Expressed throughout embryogenesis (at protein level). First detected at stage 12 in the haemocytes and in the fat body at stage 13 (at protein level). High levels also detected in the anal pads of stage 16 embryos (at protein level)
+Highly expressed in primitive adrenal cortex and placenta. Expressed at lower level in developing nervous tissues, tongue, heart, gut, kidney, columna vertebralis and liver
+Expressed at high levels in germinal vesicle (GV) stage oocytes and zygotes and at lower levels in MII-stage oocytes and 2-cell stage embryos (PubMed:24357321). Expression decreases from 2-cell stage to blastula (PubMed:24357321)
+Ubiquitously expressed in early embryos and becomes enriched in the developing heart at 48 hours post-fertilization
+Expressed both maternally and zygotically. Expressed at the 2 cell stage. Ubiquitously expressed at the 22-somite stage. Expressed in the brain and head mesenchyme, otic vesicles, fin buds, caudal vein and the heart (both myocardial and endocardial cells) at 24 hours post fertilization (hpf)
+Expressed from late embryonic stage onwards
+Expression persisted in the stigmatic tissue after fertilization and in siliques during seed maturation
+Expressed during larval stages
+IGFBP3 levels are higher during extrauterine life and peak during puberty
+In mature leaves
+Early blastoderm stages and later during nervous development
+Expressed widely and dynamically in the embryo (PubMed:16376329). Expressed in cells of the E blastomere lineage; these go on to form the intestinal primordium (PubMed:15935776). Expressed asymmetrically in the left, but not the right, E4 and E8 cells; however, expression in E8 cells disappears late in the E8 stage, then is observed on the right side of the E16 primordium (PubMed:15935776). These expression patterns are dependent on Notch signaling (PubMed:15935776). Also expressed in a subset of the AB anterior blastomere lineage, including the descendants of the ABa cells, such as ABarpap, which are precursors of the right side of the head (PubMed:15935776). Expressed in ABplp(a/p), ABalp(a/p), ABprp(a/p), ABara(a/p), and weakly in the ABarp(a/p) blastomeres at approximately 100 minutes after fertilization (PubMed:16376329). Expressed in a Notch-independent manner in the EMS lineage, in all EMS granddaughters beginning at the 24-cell stage (PubMed:15935776)
+Expressed from embryogenesis to adulthood (PubMed:32490809). Expressed in one-cell embryos, 4-cell embryos and multi-cell embryos (PubMed:32490809)
+Detected in neonate ovaries and expressed at constant levels in 3 to 6 day old animals. Levels are increased in at day 12 and thereafter
+Down-regulated as the nodules mature
+Produced in the cephalic glands of the nurse honeybee
+Expressed from the mid-pachytene spermatocyte stage to the early elongating spermatid stage
+Expressed in newly fertilized embryos, but is rapidly degraded after initiation of the first mitotic division (PubMed:12781695, PubMed:16611242, PubMed:18417623). Highly expressed in one-cell embryos (PubMed:18854162). Expressed in P-granules in blastula-stage embryos (PubMed:16611242). Weak, if any, expression during larval stages (PubMed:11702779)
+Expressed in ring, trophozoite, schizont and segmenter stages
+Expressed from 4.5 to 18.5 dpc. Initial levels are low until 6.5 dpc and residual from 7.5 to 9.5 dpc. Expression increases from 10.5 to 15.5 dpc before falling again to a level slightly higher than the one seen on 4.5 to 6.5 dpc. At 11.5 dpc, broadly expressed in the telencephalic and diencephalic vesicles. At 17.5 dpc, expressed in cerebral cortex, hippocampus, dorsal thalamus and amygdala
+Expressed in the neocortical neurons in the developing brain
+Up-regulated transiently following sterile or LPS-induced sciatic nerve injury with a peak after 4 hours
+Expression is predominantly seen in striated muscles, and strong expression in heart and skeletal muscles is observed throughout development to at least 5 dpf
+Expressed at low levels in the embryo. Expression increases after hatching and during larval stages and, despite a decrease, remains high in adults (at protein level)
+Accumulates only in cells that are going to differentiate into heterocysts
+Constant throughout the cell cycle
+Expressed during all sporogonic stages
+Detected in cotyledons prior to seed germination. Restricted to the cotyledon tip until 2 days after seed germination and then detected in the cotyledon or cotyledon veins on days 3 to 7
+Expressed during the asexual blood stage in late rings, trophozoites and schizonts (at protein level) (PubMed:27653778, PubMed:32184257). Expressed in gametocytes from stages I to IV (at protein level) (PubMed:27653778, PubMed:20332084)
+Highest levels are found in the adult with barely detectable levels in pre- and early postnatal tissue
+Expressed just before gastrulation in a narrow region on the dorsal side of the embryo. Expression can be detected in the involuted cells comprising the mesendoderm of the developing axis. At the end of gastrulation expression is turned on in the ventral neural plate in cells adjacent to the axial-expressing mesodermal cells
+Expression begins in the late gastrula
+During development, expressed when the subventricular zone (SVZ) is generated (low at 11 dpc, high at 14 dpc and low at 18 dpc)
+Expression at low levels during embryonic expression and peaks during mid larval stages
+Expressed in the seam cells of 1.2-fold embryos
+Expression found as early as 8.5 dpc. High expression is found in the developing limb buds of embryos
+Isoform 1 is more prevalent before and for 3 hours after tobacco mosaic virus (TMV) infection, while isoform 2 is more prevalent 4 to 8 hours after TMV infection
+Expressed at low levels in the inflorescence meristem (IM) and young flowers. Later confined to sepals, petals and stamen filaments. Detectable in the valve and seed coat
+Expressed in sporozoites and in liver stages (at protein level) (PubMed:27425827). Highly expressed in male gametocytes and exflagellated gametes, and to a lesser extent, in female gametocytes (at protein level) (PubMed:15137943, PubMed:28481199). Expressed in ookinetes (PubMed:15137943). Weakly or not expressed in asexual parasite stages (PubMed:15137943)
+Slightly induced 12 days after germination
+Expression in central cell of the mature female gametophyte is pollination independent
+Expressed from late G1 phase
+Low levels in larvae and pupae, but increases in young adults, becoming relatively stable in two-day-old flies
+In anthers, barely detected in microsporocytes at stage 6, but accumulates strongly in tetrads at stage 7, microspores, mature pollen grains, and tapetum cells. Also detectable in the growing pollen tubes on the stigma
+Expression doesn't begin until the late gastrula stage. Levels then accumulate continuously, peaking during tailbud stages (stage 31) before decreasing during the tadpole stages
+Expressed during larval development (PubMed:20144761). Expressed in brain in third instar larvae (at protein level) (PubMed:28366641)
+Non-dividing gametes did not express the VH-PTP13 gene whereas synchronously dividing vegetative cells only expressed VH-PTP13 in the early G1-phase of the cycle
+Restricted to developing blood cells
+Pluripotent cell-specific. Expressed in zygotes, cleavage-stage embryos and blastocysts, embryonic stem (ES) and embryonic germ (EG) cells. Detected in both the trophectoderm (TE) and inner cell mass (ICM) of blastocysts. More abundant in the ICM than TE at 3.5 dpc blastocyst stage. Expressed in primordial germ (PGC) cells from 10.5 to 13.5 dpc. Expressed in developing gonads from 11.5 to 15.5 dpc. Progressively undetectable in ovary from 13.5 to 15.5 dpc. Undetectable in testis after 15.5 dpc. Not expressed in somatic cells at 13.5 dpc (at protein level). Expressed in embryonic stem (ES) and embryonic carcinoma (EC) cells. Not detected during the differentiation of stem cells or midgestation embryos nor in neonatal tissues. Weakly expressed or not detected in oocytes and fertilized eggs
+Expressed throughout development, expression peaking at the aggregation stage. Expression is localized in the prespore region and tip region of the tipped aggregate. At slug stage, expression is predominantly in the posterior prespore region. In the fruiting body expression is detected in basal disk and spore region containing upper cup and lower cup
+Expressed 2.5 hours after induction of meiosis
+Expressed in all larval stages with levels peaking at the L3 larval stage and decreasing in the adult
+The beta form is expressed in embryonic developmental stage (7 and 11 days). The beta form is an embryonic and a bone marrow form of NPY1-R, which decreases in the expression during development and differentiation
+High expression in stomatal meristemoids, but ceased during the differentiation of guard cells
+Expressed in all developmental stages with higher expression in adults (PubMed:33770502). Also detected in the egg stage to a much lower level (PubMed:33770502)
+Expressed during development; especially until 8 hours of development (PubMed:16086850). Expression is higher in the tip regions of slugs and early culminants (PubMed:11422293)
+Expressed from the 100-cell stage in posterior progeny of ABp(l/r)pp and ABp(l/r)ap (PubMed:20824072). Expressed in the tail tip cells hyp8-11 throughout larval development in both sexes (PubMed:21408209). Expressed in the linker cell from the L3 larval stage onward (PubMed:27472063)
+Expression in gonads starts around 3 weeks of age, which corresponds to the start of sex determination. Expression remains present in the adult gonads, both in males and females, although expression is weaker in testis
+Expressed in third stage larvae
+Expressed at the basal part of the abaxial side of leaves in the vegetative phase (PubMed:25535376). In the reproductive phase, expressed in the bracts of initiating branches (PubMed:25535376)
+Detected in embryos from 7 dpc to 17 dpc. Expression decreases in developing skeletal muscles
+Highly expressed during embryogenesis from 7 dpc onwards
+Expressed both maternally and zygotically through all developmental stages
+Expressed in maturing embryos, with a maximum at 35 days after pollination. Decreases rapidly after imbibition
+Predominantly synthesized during the later stage of gestation
+Expressed in the developing cerebral neocortex and glanglionic eminence in 57 days post-fertilization fetal brain
+Expressed in the larval trachea (at protein level)
+In primary roots and mature lateral roots (LRs), expressed in cortex and epidermis from the border of the maturation zone up to the colet (PubMed:23370719). Restricted to the nonhair cell files in the epidermis, but present in all cortical cells regardless of their position (PubMed:23370719). Induced during lateral root formation in mature lateral roots (PubMed:23370719). Patchy expression in cotyledons and leaves, but accumulates at the base of the cotyledon petioles and in stipules (PubMed:23370719). In flowers, irregular repartition in the sepals and pollen grains (PubMed:23370719)
+In larvae, expressed in the central nervous system
+First expressed at stage 12/13 (gastrula) of embryogenesis, with expression increasing through the tadpole stages
+At 18 dpc and P1 expressed predominantly in thymus and liver, and at lower levels in brain, muscle and kidney
+During testicular development (from 2 to 45 days of age), expressed from 14 days and then increases steadily with an advancement of age
+Expressed at relatively constant levels throughout embryogenesis
+Expressed throughout embryogenesis; first appears at 8-10 hours. Detected in larval and pupal stages (at protein level). Transcripts are first detected at 6-8 hours of development, expression peaks at 12-14 hours and then declines by the end of embryogenesis
+Mostly present in young pupal wings and larval tubercles. Faintly present in younger than 24 hours old pupal forewing and hindwing. Weakly detected in hindwing and tubercles
+At 9 dpc, expression is prominent in the neural tube and somites
+Transcribed in developmentally important regions that give rise to skeletal muscle, tendons, cartilage, male gonads, and the ureteric buds of the kidney. Expressed in discrete premyogenic cell populations of the somite, in the condensing prechondrogenic mesenchymal cells of the axial skeleton, in the pretendenous cells of the tail and limbs, the testis cords of the developing male gonad, and in the metanephric kidney
+Cell-cycle regulated: levels are highest early in S phase; not detectable in G2
+Highly expressed in 17 dpc ovaries. Expression is significantly reduced in newborn ovaries, and is undetectable in ovaries from 5 day and 8 week old mice
+Expressed abundantly in hair follicles during the anagen phase. Low expression is observed before birth, then follows hair cycle progression: up-regulated markedly during P5-P15 (anagen phase), declining to nearly the basal level during P20-P25 (catagen and telogen) and then increasing again at P30 (next anagen)
+Expressed during the asexual blood stage including during the ring stage and then in trophozoites (at protein level) (PubMed:31851913). Expressed in all 5 gametocyte stages (PubMed:31851913)
+Expressed in liver at 14 dpc. Expression level increases at P5 and decreases after P21
+Highly expressed during vegetative growth. Down-regulated in starving cells and during development
+Detected in embryo, third instar larva and adult
+Expressed at 8.5 dpc in structures required for skeletal patterning. Highly expressed at 11 dpc, and decreases markedly from 15 dpc
+Expressed in the cytoplasm of germinal vesicle oocytes before becoming concentrated in the subcortex of metaphase 2 oocytes (PubMed:28992324). Expressed in ovaries at birth, expression peaks at postnatal day 10 (P10), expression is then decreased at P17 and further decreased at P21 (PubMed:31575650)
+First expressed at 15 hours post-fertilization (hpf), segmentally in the ventral region of the spinal cord (primary motoneurons) and then later in the dorsal regions (Rohan-Beard neurons). At 18 hpf, also expressed in tail bud and pronephric duct. At 24 hpf, expressed strongly in trigeminal ganglia. At 30 hpf, expressed transiently in pectoral fin bud
+Expressed very broadly throughout the embryo, from the one-cell stage until the comma stage, when expression diminishes, and is not observed after hatching in larvae or in adults (PubMed:21555395). Expressed in both ASE neurons in the comma-stage embryo (PubMed:21555395)
+Absent in stage VI oocytes and is expressed from meiosis II until gastrulation
+Expressed throughout embryonic development and adulthood
+Expressed during L4 stage, during spermatogenesis, when hermaphrodites produces sperm
+Found at low level from 7 dpc and increased during embryonic development
+Detected from embryonic stage 16.5 dpc onwards, with marked increase in expression level after birth
+First detected in round spermatids at stage 4 and expression strongly increases through stages 5-8. Localization in the nucleus is highly polar and it is concentrated in a cap-like structure at the inner periphery of the nuclear membrane. Polarized expression persists in steps 9-14 elongating spermatids before rapidly disappearing by stage 15
+It is present but some of the disulfide bonds are reduced in the intracellular reticulate bodies (RBs)
+Required for epidermal patterning during postembryonic root development, but not involved in hypocotyl development
+At 3.5 dpc, weak and transient expression in the inner cell mass cells of blastocysts. This expression disappears by 5.5 dpc. Expression starts again in committed PGCs around 6.5 dpc in the extraembryonic mesoderm contiguous from the most proximal epiblast (at protein level). Expression persists specifically in PGCs until about 13.5-14.5 dpc both in females and males
+Expressed in the syncytial embryo
+During the 1.5 fold embryo stage, detected in the AVG pioneer neuron and in the developing ventral nerve cord. At larval stage L1, detected in the AVG, CEPDL/R, RMDVL/R, RIVL/R, AVAL/R, RMDL/R, and RMDDL/R neurons. At larval stage L4, expression continues in the AVG neuron and a subset of nerve ring neurons that extend axons into the right ventral nerve cord
+Accumulates in the pistil around 120 hours before anthesis and increases towards the end of flower development, with a maximum at anthesis
+Exclusively expressed in restricted domains of the developing central nervous system, in particular the diencephalon and rhombencephalon, where it is expressed in migrating cells giving rise to the cerebellar external granular layer and to specific populations of dorsal sensory interneurons of the spinal cord
+At P0 expression is primarily in the basal hook to lower middle turn of the cochlea and progressively expands toward the apex over time. By P8, the expression is evident in both IHCs and OHCs along the entire length of the cochlea. Then the adult pattern begins to emerge, as expression in basal OHCs and in apical IHCs decreases
+Expressed throughout development. Highest expression during larval development
+The NDH complex is 2.5-3 times more abundant in bundle sheath than mesophyll cells
+Expressed in seeds during late stage of development
+Maximally expressed at the beginning of gastrulation
+Expressed in host lung L3 larvae (at protein level)
+Weakly expressed in retina on embryonic day 18, with levels increasing until day 6 after hatching and then remaining high until day 21 (at protein level)
+Low expression in young plants (up to 4 weeks), then slight increase in older plants
+Low expression at day 24 gestation in fetal liver. Expression increases dramatically thereafter to day 30. Levels then remain constant up to day 40
+Accumulates progressively during ovary development
+Expression starts when the berries began to change the color. It increases throughout berry development to reach a maximum level in very mature berries
+Expressed in the floor plate and ventral portions of the developing neural tube of 12.5 dpc to 13 dpc mouse embryos. Found in developing neuronal projections (at protein level)
+Isoform a but not isoform b is expressed maternally. Both isoform a and isoform b are expressed zygotically
+Weakly expressed in testes from 18 day postcoitus to 1 day postpartum (dpp), with a plateau starting around 8 dpp; and testicular expression shows two-peak expression at around 14 dpp and 24 dpp, then exhibits stable expression from 6-week after birth onward
+T-cell specific expression rises during the differentiation of CD8 T-cell progenitors into memory CD8 T-cells
+Expression is low in vegetative hyphae and increases during conidiophore development
+Isoform 2 and isoform 3 are first seen on postnatal day 16 corresponding to the age when midpachytene spermatocytes are present in the synchronous first wave of spermatogenesis. Isoform 2 and isoform 3 levels increase substantially between days 14 and 18 and continue to increase to age 30 days of neonatal testis development
+Down-regulated during T lymphocyte activation
+During flowers development, mostly observed in ovaries during the biosynthetically most active stages (e.g. stages 2, 3 and 4, when petals are progressively opening)
+In the adult brain it is found in the cerebellar granule cell layer while the expression during the gestation period is region specific, at the junction of the midbrain and hindbrain
+Expressed both maternally and zygotically. Expressed in preblastoderm embryos, followed by complete decay upon formation of the cellular blastoderm when ftz striped expression is at its peak
+Activity is predominant during late exponential growth and at the start of the conidiation process
+In L4 stage, expressed in vulva, ventral nerve cord, tail and at higher levels in hypodermis
+In brain expression is negligible at birth, then increases linearly, reaching a maximum at about 3 weeks postpartum
+Detected at low levels in eggs and in embryos at stage 12. Expression increases from stage 18 to 34 during embryonic development (at protein level). First detected at stage 17, when somites begin to form. Detected in somites, neural tube and neural crest cells at stage 20-30
+Primarily expressed at postnatal day 10 in the dorsal root ganglia where expression gradually increases as the development proceed
+Expressed at high levels in the pituitary, diencephalon, mesencephalon, and hypothalamus in embryos at Carnegie stage 22
+Expressed at 10 hours and 12 hours in presumptive diencephalon. Expressed transiently at 12 hours in caudal telencephalon. Later expression in floor plate and somites, followed by rostral telencephalon and ventral thalamus. Expressed at 40 hours in hypothalamus
+Expressed early in fetal white adipose tissues from 17 to 21 weeks of gestation (at protein level)
+Expression reaching a maximum in 2-week-old plants and a minimum in flowering plants
+At 12.5 dpc, the highest level of expression is in the spinal cord and lower expression levels are seen in the developing brain. At 15.5 dpc, highly expressed in brain, spinal cord and eyes (PubMed:11044403). In developing kidney, at 17.5 dpc, low expression is observed in the glomerulus, while high expression levels are detected in the proximal tubule (PubMed:26859289). At 14.5 dpc, is expressed within the epithelial compartment of the embryonic mammary bud and at lower level in the surrounding stroma and skin. Also expressed at terminal end bunds (TEB) at comparable levels in body and cap cells as well as in fibroblasts and stroma surrounding the TEB (PubMed:21945077)
+Levels increase in the iris from embryonic day 9 (9 dpc) to 16 dpc in contrast to the choroid where it remains low relative to iris. During early hindbrain development strongly expressed in rhombomeres R2, R4, R5 and R6 but not in R3. Expression in R3 is seen at later stages and is dependent on neighboring interactions
+Shows a relatively higher expression level in the fetal brain and a lower level in adult. The expression level in liver is highest at 16 weeks of development and declines from 16 to 24 weeks and is lower in adult. Expressed strongly in fetal heart on 18 and 24 weeks, but relatively weakly on the other development stage of embryo, and then reaches a higher level in adult (isoform 3)
+Expressed in retina at 48 hours post-fertilization (at protein level). Detected in all retinal cell layers but has particularly strong expression in the outer nuclear layer and ganglion cell layer (at protein level)
+During seed development, expressed from 30 to 65 days after flowering (DAF), with a peak at 50 DAF
+Expressed in stage 6 egg chambers
+Appears at the beginning of gastrulation. Plateau between the neurula and middle-tailbud stages, and decrease steadily thereafter
+First detected in early tailbud (stage 23/24). Highest levels in whole tadpole found around stage 47/48. In the intestine, increased levels are found during metamorphosis (stages 58-64) and in the hindlimb, expressed at low levels during metamorphosis until stage 66 when levels dramatically increase. In the tail, a constant high level of expression is found throughout metamorphosis
+Increases after starvation is initiated with a peak between 8-12 hours of starvation
+In germ cells, has highest expression levels during late spermiogenesis (in round spermatids and condensing spermatids)
+During embryonic development, highly expressed at 8 hours post-fertilization (hpf) (PubMed:28402832). Expressed at the pharyngula stage at 24 hpf and expression is maintained 48 hpf, 72 hpf and to larval day 4 of development at 96 hpf (PubMed:29791492, PubMed:28402832). During this time, expressed in the pharyngeal arches, and in the intestinal bulb at 72 and 96 hpf (PubMed:29791492, PubMed:12464617). Also expressed in the epidermis and mouth at 48 and 72 hpf (PubMed:12464617)
+Barely detectable in stage I/II oocytes, accumulate in stage III/IV oocytes, then exhibit a roughly constant steady state level in mature oocytes, eggs, and early embryos
+In the forming silique, expressed in the funiculus and ovule from 1 to 3 day after flowering (DAF). At 3 DAF, expressed in the globular embryo, but expression decreases at 5 DAF and almost disappears at 7 DAF in the embryo. By 1 d after imbibition, expressed in the tip of seed radicle and then in the root tip up to 4 d after imbibition
+First expressed at 15 hours post-fertilization (hpf) in the presumptive proctodeum. At 22 hpf, expressed in the most distal part of the hindgut, the future rectum and the cloacal region; cloacal expression is still detectable until 64 hpf. First detected in the dorsal pre-somitic mesoderm and neural keel at 17 hpf. At 22-26 hpf, expression is restricted to the posterior tip of the trunk, begins to weaken and is undetectable by 40-56 hpf
+Present early in development. During oogenesis and maturation, low levels are detected in growing oocyte stages V-VI. Expression increases significantly during oocyte maturation. After fertilization, the level decreases slowly until the mid-blastula transition (MBT, stage 8.5). A sharper decrease occurs after MBT. Not detected in embryos past stage 10 of development (at protein level)
+Expression in the embryo overlaps that of LIM domain-containing proteins (PubMed:9192866). Expressed widely in the embryo with highest expression in several regions of the brain, and the central nervous system ganglia (PubMed:8918878, PubMed:9391090, PubMed:9192866). Also expressed in fetal liver, lung, kidney, thymus and olfactory epithelium (PubMed:9192866, PubMed:16815859, PubMed:9391090). Expressed in, but not restricted to, the basal compartment of interfollicular epidermis, the developing hair follicles during embryogenesis and, in adult hair, expressed in matrix cells and the outer root sheath (PubMed:9860983). Expressed in both embryonic and adult hemopoietic cells, including the erythroid lineage (PubMed:9391090)
+Expression first detected in heart at 9.5 dpc and persisted in the adult
+Widely expressed prior to and throughout gastrulation, and in mid-somitic embryos. From 24 hours post-fertilization (hpf) onward, and up to the latest time point assessed (72 hpf), expression is detected in anterior structures including the brain, eye and mandible
+Expressed early in the G2 phase, reaches a peak at mitosis and then decreases. Expressed in the developing embryo up to the late-heart and early-torpedo stages
+During embryo development, expressed in the top of the scutellum at 7 days after pollination (DAP). In the germinating embryos, expressed in the scutellum and the cap of the radicle at 2 days after germination (DAG). At 4 DAG, still expressed in scutellum, and appears in the vascular bundle of shoot. In florets of young panicle, expressed in the pedicel and the basement of glumes. In florets of older panicle, expressed in the pedicel, basement of glumes, anthers and pistils. Expressed in the basal parts of ovaries before pollination and in the basal parts of stigmas and ovaries after pollination
+In male testis, it is expressed as early as 12.5 dpc. After birth, it localizes to type A spermatogonia in 7-day-old testis and adult testis, but not in spermatocytes. In spermatogonia, it is initially detected in stage IV Aal spermatogonia and strongly expressed in Aal, A1, A2, A3, A4, intermediate and type B spermatogonia (at protein level). In ovary, it is detected at 15.5 dpc, when oocytes have entered meiosis I, although a low level expression is detectable at 13.5 dpc. Expressed in oocytes of germ cell cysts as well as primordial follicles in the newborn ovary. In adult ovaries, it is preferentially expressed in primordial oocytes but disappear rapidly as the oocytes are recruited to form primary and secondary (multilayer and preantral) follicles. During oocyte differentiation, protein appearance at 15.5 dpc correlates with SOHLH2 translocation from the cytoplasm into the nucleus and is dependent on SOHLH2 expression (PubMed:28504655)
+Expressed in both the insect and mammalian life-cycle stages
+Expressed in the embryonic ventricular zone, the postnatal ependymal cells, and the choroid plexus throughout embryonic and postnatal development
+Expressed in placenta at 14.5 dpc
+First expressed at early heart stage onward in all root basal daughter cells resulting from horizontal divisions in the COL progenitors and is later maintained in these cells. Present in root stem cell daughters and accumulates in maturing root cap layers. Detectable from very early stages of lateral root development
+Only detected in vegetative growing cells
+Expressed both maternally and zygotically, from ova through to 48 hours post-fertilization. At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 5. At the 20-somite stage, expressed in the developing CNS with an anterior expression adjacent to the somite 2/3 boundary
+Up-regulated during the early stage of fruit ripening
+During early embryogenesis, predominantly expressed at 6.5 dpc and 9.5 dpc in the forebrain, mid-hindbrain boundary, branchial arches, somites, limb bud and tailbud. At 12.5 dpc additionally expressed in the diencephalon, optic stalk, pituitary, olfactory and oral epithelium, tooth primordia, somites, developing metanephric kidney and stomach. Expressed in the neopallial cortex, rhombic lip and dorsal regions of the myelencephalon and in the frontal nasal process. Expressed in the commissural plate and septal area of the forebrain and in the hippocampus, lens and optic cup. In the oral region, expressed in the tongue and in the mesenchyme of the first branchial arch. Also expressed in the developing inner ear. Expression patterns remain essentially unchanged at 15.5 dpc, with the addition of a strong expression in the submandibular gland
+Is detected in all developmental stages, though it appears most abundant in pupae, adult stages and early embryos. Its abundance decreases throughout embryonic and larval development and then returns to high levels in pupae and adult females
+Expressed in blastoderm embryos (at protein level). Abundantly expressed in late-stage embryos including in the developing salivary glands (at protein level)
+Expressed at the end of flowering and during seed maturation
+Levels increase strongly upon imbibition and decrease 3 days later. Strongly induced in leaves during senescence
+Is expressed in the forespore under the control of sigma-G, and in the mother cell under the control of sigma-E
+Increases during pregnancy (5.0-fold increase on day 12 with a subsequent decrease on day 18) and during lactation (18.5-fold increase on day 7). Levels appear to be minimally altered during involution
+Expression coincides with myogenesis: expression is initiated between 12 and 14 hours post-fertilization (hpf), peaks at 19.5 hpf, gradually decreases thereafter and disappears at 36 hpf (PubMed:29078404). Specifically expressed in the developing somites, concomitant with muscle differentiation (PubMed:29078404). Present in all developing myotomes in 14-hpf (10 somites), 18-hpf (18-19 somites), and 19.5-hpf (21 somites) embryos (PubMed:29078404). As somitogenesis proceeds along the anteroposterior axis, expression gradually disappears from the differentiated anterior somites and shifts to the more caudal somites (PubMed:29078404). Not expressed in craniofacial muscles and the paraxial mesoderm (PubMed:29078404)
+Expressed in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas
+Expressed in the growing region of internodes
+Expressed in the developing embryos and endosperm, then decreases when embryos mature and soon after cellularization in the endosperm. After germination, it is expressed in the shoot apical meristems (SAMs), leaf primordia, and young leaves. In the reproductive shoots, it is expressed in both the influorescence and floral meristems. Later, it is expressed in floral organ primordia. In coflorescences, it is expressed in SAMs and lateral organs. In roots, it is expressed in root tips
+Appears just before birth, reaches maximum levels after birth, then declines slightly until adulthood
+Throughout development
+Probably maternally supplied. No zygotic expression is detected before 7.5 hpf
+Expressed during fruit ripening but absent in senescent leaves
+Detected at 16.5 dpc in the outer cortex of the developing brain
+First detected at 14.5 dpc in the nasopharyngeal epithelium and persists there into adulthood. In the thymus, weak expression is detected at 16.5 dpc and appears to be restricted to epithelial cells lining the medullary venules. This pattern of thymic expression persists until birth and into early postnatal life but is greatly decreased in the adult thymus. No expression is detected in the lung until 2 days after birth, after which expression is detected in cells lining the trachea
+In the retina, expression increases throughout postnatal development and remains high in the adult (at protein level)
+Expressed during plant development
+Detected from 7 dpc
+Expressed prior to the formation of distinct motor axon pathways and before the segregation of motor neurons into columns. Expressed throughout the median and lateral motor column
+Isoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and kidney
+Expressed in the endothelium of the developing heart and aorta and in the neural tube at 10.5 dpc, and in the arterial endothelium, smooth muscle, endocardium of the heart and brain vasculature at 14.5 dpc
+Expressed in early stages of pancreatic development. First expressed in 8.5 dpc embryos in the dorsal part of the midgut endoderm and by 9.5 dpc, in the pancreatic rudiment specifically in early endocrine progenitor cells. At later stages expressed in insulin- or glucagon-producing cells. During neural development, the type 2 PTP-NP is expressed in early stages of neurogenesis, and the type 1 weakly in the later stages
+Expression levels are regulated during the cell cycle with increased levels during early and mid S-phase
+Do not show cell-type-specific expression
+Strongly expressed in hemocytes and midgut, and at a lower level in epidermis, wing disks, ovaries, silk gland and fat body, on day 2 of the wandering stage (W2) larvae (PubMed:15898116). In wing disks, expression increases from W2, showing a small peak on day 3 of the wandering stage (W3). In wing tissues, expression increases after pupation, showing a high peak on day 3 of the pupal stage (P3). In fat body, expression peaks at W2 and on day 1 of the pupal stage (P1) through P3. In midgut, highly expressed around pupation from W3 to P1. In silk glands, expression shows a high broad peak at W3 and the highest expression on the day of pupation (P0), maintaining a low level after P1. In hemocytes, expression peaks broadly at W2 and W3. The expression level is the highest in silk glands of all the organs examined (PubMed:28943345)
+Detected in diploid pre-meiotic spermatocytes, haploid spermatids and elongated spermatids (PubMed:28617811, PubMed:15372036). Restricted to junctional plaques in the heads of elongated spermatids (at protein level) (PubMed:15372036)
+At 17 dpc, isoform 2 is expressed in the CNS and PNS. Isoform 2 is expressed at high levels in the dorsal root ganglia, trigeminal ganglia, and throughout the spinal cord with the highest level in the ventral horn
+Expressed at higher levels in younger, faster growing leaves than in older, slower growing leaves
+Expressed in embryo at 7, 11, 15 and 17 dpc
+Peaks perinatally in brain and cerebellum, and at puberty in testis, in concomitance with differentiation events occurring in neurons and germ cells
+Expressed in the male-specific ciliated sensory neurons, including the two hook neurons, and the 36 ray neurons at the L4 larval stage
+In stage 16 embryo, restricted to all differentiating mechanosensory chordotonal (Ch) neurons (lch5, v'ch1, and vchAB) (at protein level) (PubMed:34553759). In pupae, expression is restricted to the neuronal cell bodies and dendrite inner segments of Ch neurons within the Johnston's organ (at protein level) (PubMed:34553759)
+First expressed in embryos that are starting to elongate, before hemidesmosomes-associated filaments are recruited to regions of the hypodermis adjacent to muscle. Expressed throughout larval stages and in adults
+At 8.5 dpc expressed at the surface ectoderm outside the neural folds, somites, presomitic mesoderm. At 9.5 dpc expressed at the nasal and otic placodes, cranial ganglia, branchial arches, somites (dermamyotomes and sclerotomes). At 10.5-11.5 dpc expressed at the nasal pits, otic vesicles, cranial ganglia, dorsal root ganglia, branchial arches, somites, myotomes, limb mesenchyme, notochord, mesonephros. At 12.5-13.5 dpc expressed in skeletal muscles, mesenchyme in limbs and digits, nasal epithelium, inner ear (PubMed:11313460). Weakly expressed in the nephrogenic cord on 9.5 dpc and in the metanephric mesenchyme on 10.5 dpc (PubMed:17300925). At 11.5 dpc expressed in the epithelium of the lateral lingual swellings, and in the tongue epithelium, mesenchyme, and muscles at 12.5 dpc. In the fungiform papillae, expressed in the epithelium at 14-16.5 dpc. In the circumvallate and foliate papillae, expression is observed in the trench wall of these papillae at 15.5 dpc-P0 (PubMed:21978088). At 11.5 dpc mainly found in limbs, and somites, where is expressed in the dorsal root ganglion, myotomes, and ventral and dorsal dermomyotomal lips (PubMed:15788460). Expressed in a wide domain of the ectoderm in the presumptive olfactory region and in the thickened olfactory placode. Expressed in the peripheral precursors of the pit. At 12.5 dpc-14.5 dpc, expression become progressively restricted to the apical and basal progenitors.Also expressed strongly in the preplacodal region at 8.0 dpc and in the presumptive olfactory ectoderm at 9.0 dpc (PubMed:19027001). At 10.5 dpc expressed in the progenitors of the dermomyotome and in the myocytes (PubMed:19962975)
+Unfertilized eggs and early Xenopus embryos
+Expressed in fat body of fifth instar larvae after bacterial challenge (PubMed:12706633, PubMed:16731347). Expressed in naive 2 h (precellular blastoderm stage) and 24 h (predorsal closure stage) eggs (PubMed:14728663)
+Expression significantly up-regulated in the middle of the L3 (22 hours) and L4 (26 hours) larval stages
+Expression correlated with organs growth and cell division activities
+At 4 days-post-fertilization (dpf), expressed in the inner and outer plexiform layers and the ganglion cell layer of the retina, the marginal zone of the tegmentum, and in the developing craniofacial cartilage
+In floral buds, early expressed before the activation of the abscission zone and the expression of most of the genes known to be involved in floral organ shedding
+Present throughout the cotyledons as well as in the mature regions of roots in young seedlings. Expressed in expanding leaves, but not in leaf primordia and juvenile leaves. In flowers, accumulates in sepals and stamen filaments, as well as at the apices and bases of siliques
+Low expression in young flowers (roughly before anther stage 6). Maximum levels around stages 6?7 that fade out gradually to a very low level in young siliques. Never detected in microspores or pollen
+Highly expressed in germinating seedlings
+In flowers, levels are reaching a maximum in buds and open flowers before declining during pod development and maturation. Strongly expressed in pollen grains within the anthers of young and mature flowers. Occasionally present in the testa of developing seeds
+Strong expression in the liver of 14 dpc embryo. In embryo of 18 dpc expressed strongly in brain, moderate expression in spleen and brain and weak expression in liver
+Expressed at the posterior region of the lens vesicle at embryonic stage 11.5 dpc. Detected at the tip of elongating lens fiber cells at stage 12.5 dpc. Expressed in lens epithelial cells, and weakly in retina, at stage 15.5 dpc
+In spleen levels are lower in adult than in fetal tissue
+Not detected in the embryo. Expressed from early larvae at a high level, levels decrease in later larvae and then increase again at adult stages
+In testis, it is expressed during a narrow window of meiosis, beginning at the onset of the first meiotic prophase and ending by the pachytene stage. Expressed during leptoten and zygotene stages of spermatogenesis
+First detected at stage 17 as 2 symmetric patches in the region of the presumptive olfactory placode. Expressed in the pineal at stage 23, and in the eye starting from stage 24. By stage 27, strongly expressed in retina, olfactory placodes and pineal. At stage 32, expression strongly decreases in olfactory placodes and pineal but is maintained in the neuroretina. At stage 41, expression is restricted to the ciliary marginal zone of the retina
+Expressed in cerebellum during embryogenesis. Highly expressed at 17.5 dpc in the cerebellar granule neurons precursors
+Highly expressed in crypt regions and barely detectable in villi in epithelium from fetal small intestine at week 16. At week 22 expression in villi had increased strongly
+Expressed in male cones before, during, and after meiosis
+At the 4- to 5-somite stage (4/5S) found in the embryo in scattered cells across the neural plate in the presumptive mid/ hindbrain region (PubMed:10662503). At 7/8S found in the isthmus and throughout the presumptive r1 territory. Between 10-14S stage found throughout the R1 region and at the isthmic constriction (PubMed:10662503). By 26S the anterior limit of expression extends into the posterior midbrain region and this pattern of expression is maintained at later stages (PubMed:10662503)
+Mainly expressed in young and rapidly developing tissues
+Expressed at low levels in 10.5- and 11.5-dpc embryos. Expression was not detected at 12.5- and 13.5-dpc. Highly expressed in the epithelial monolayer lining in a subset of tubules of embryonic kidney cortex. Low levels of expression were detected in 16.5-dpc embryonic intestine, limb, lung, and skin. No expression was detected in the brain. Expression is regulated in at least two distinct sites, the pluripotent cells of the developing embryo and the epithelial cells lining the embryonic kidney distal convoluted tubules. Expressed in the ducts of submandibular and sublingual glands, isolated submandibular gland, parotid and lachrymal glands and nasal gland in 16 dpc embryos. At birth, the expression is detected in minor nasal glands in the olfactory epithelium, ducts of the mammary gland, male reproductive system, endolymphatic sac and lung. Expressed during renal development; first detected in the ureteric epithelium, at the distal end of the S-shaped body in nephron and subsequently in all nephric tubule, with expression localizing to more distal regions in the nephron during the maturation of the kidney
+During limb development, at 14.5 dpc, ubiquitously expressed in the limb bud. In developing lungs, at 14.5 dpc, ubiquitously expressed
+Expressed both maternally and zygotically. Already present in fertilized eggs. Expression levels increase until the sphere stage and reduce gradually toward 24 hpf (at protein level)
+At 8.5 dpc, expressed in the primitive streak, rostral forebrain, cells lateral to the posterior hindbrain, anterior hindbrain and developing midbrain (PubMed:10498682). At 9.5 dpc, continues to be expressed in the rostral forebrain and primitive streak, and is also detected in the branchial arches and the forelimb bud (PubMed:10498682). At 10.5 dpc, expressed in the somites, frontonasal processes, tailbud, and hindlimb bud (PubMed:10498682)
+Expression is increased between P1 and P15 in the spinal cord and a differential spatial pattern. In the P1 spinal cord there is a preferential expression in regions of dorsal laminae II and III and laminae IX ventrally; while in P8, the distribution is more widespread and overall expression is increased
+In the newborn kidney, weak expression is first observed in podocytes in the late S-shaped body or early capillary loop stage, increases with glomerular maturation and persists at a high level in mature glomeruli (at protein level) (PubMed:32390516). Expressed in skeletal muscle at 17.5 dpc until post natal day P0 and then decreases at P21 (PubMed:23401856)
+Expressed most strongly in early exponential growth, with levels falling off as cells reached late log phase and stationary phase
+Expressed transiently in developing spinal cord and selectively in the postnatal cerebellum
+First detected when type B spermatogonia give rise to early meiotic cells (preleptotene, leptotene and zygotene) at 10-12 days post partum (dpp), producing a clearly detectable protein at 12 dpp (at protein level)
+Expressed early in development with little transcript remaining following aggregation
+Expressed in the blastoderm margin. Expression shifts to the spinal cord and endodermal tissue at the somitogenesis stage
+Expressed in the central nervous system and in muscle at 16 dpc and onward (PubMed:18611855). Expressed in the inner ear and retina at 15.5 and 17.5 dpc (PubMed:23023331). Detected in stereocilia of cochlear hair cells at P12 and as early as P5 (at protein level) (PubMed:28663585). At P12, expressed in stereocilia and at the tips of surrounding microvilli of the auditory hair cells (at protein level) (PubMed:28663585). At P12 in the inner hair cells, distributed along the length of stereocilia and accumulated at the tips of the shortest, but still mechanotransducing, stereocili (at protein level) (PubMed:28663585). At P12 in the outer hair cells (OHCs), punctate labeling along the length of stereocilia, including labeling at the very tips of OHC stereocilia (at protein level) (PubMed:28663585)
+Present in myotubes and also in undifferentiated myoblasts
+In flowers, first observed in both stigmatic papillae and the flower abscission zone, later confined to the abscission zone (PubMed:17310369). In leaves, level increases gradually up to the point of leaf senescence (PubMed:17310369, PubMed:22268143)
+Expression in the uterus changes during the menstrual cycle (PubMed:15657371, PubMed:16339169). In endometrium, expression is higher in the menstrual, proliferative, and early secretory phases than in the mid-late secretory phase (PubMed:15657371, PubMed:16339169). In the ovaries, expression is ovulation-dependent, levels are negligible in preovulatory follicles, and increase in postovulatory follicles and in the corpus luteum (PubMed:27169804)
+Ubiquitously expressed in embryos and newly hatched larvae. Expressed in all P(3-8).p vulval precursor cells at the time of vulval induction and until after all cell divisions and vulval morphogenesis are complete
+Expressed progressively during flower development reaching the highest level in the mature fertilized flower stage
+Strongly induced postnatally
+Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all 12.5 dpc epithelia, gradually becoming confined to the basal cell layers during
+Expressed in naive 2 h (precellular blastoderm stage) and 24 h (predorsal closure stage) eggs
+It is present in constant amounts throughout vitellogenesis, decreases between the end of vitellogenesis and the onset of choriogenesis and increases again during the later stages of choriogenesis (but levels remain lower than that observed during vitellogenesis)
+Detected in mitotic eggs (at protein level)
+In developing seeds, it is expressed in the embryo, suspensor and endosperm nuclei, but absent in the integuments. In seedlings, it is expressed in the shoot apical meristem and leaf primordia, but not in expanded cotyledons or mature leaves. In reproductive structures, transcripts could be detected in floral apical meristems, floral primordia, stamens and pistils. Also expressed in the tapetum in anthers and in the gynoecium. Weakly expressed in petals, sepals and the walls of carpels
+In the anthers, specifically expressed in pollen, with levels varying during the different developmental stages
+Weakly or not expressed in fetal testis. Highly expressed in adult testis and moderately in elderly testis
+Probably maternally supplied, the zygotic expression becomes significative at 6 hpf and increases from 7.5 hpf to 24 hpf
+Expressed during embryogenesis and during the early stages of germination
+Detected at low levels of expression at 3.5 and 6.5 days post coitum (dpc). At 7.5 dpc, it is detected in the ectoderm, mesoderm, and ectoplacental cone. By 8.5 dpc, expression is increased, specifically in the central nervous system, neural plate, and neural tube, which remains constant until 10.5 dpc where it decreases. By 11.5 to 15.5 dpc, expression is reduced further in the central nervous system
+Expressed during the early-to-late cotyledon stage of seed maturation
+Highest level of isoform 1 in the brain of newborn rats. Increasing levels of isoforms 2, 3, 4, and 5 in the brain of newborn rats from birth to 6 weeks of postnatal development. Increasing but low level of isoform 6 is expressed in the brain from 2 to 6 weeks of postnatal development
+Detected at high levels in brain throughout embryonic development (at protein level). Levels are lower in neonates and decrease during the first days after birth (at protein level)
+Expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation and reduced cell proliferation
+Expressed in late gastrulae stage G6 to larval stage L2
+Expressed in the apical parts of the developing gynoecium. In carpels, first observed at late development stage in the most apical parts of the open-ended gynoecium. Accumulates in differentiating style and stigmatic tissues. Not expressed in the stigma after fertilization but remains in the style until full silique maturation. Also detected in anthers. In seedlings, present in the shoot apex and in cotyledons, leaf primordia, stipules, hydathodes and in primordia of lateral roots. Detected in developing trichomes and in leaf and pedicel attachment sites
+Abundantly expressed during formation of fruiting bodies (expressed in monokaryons and dikaryons). Accumulates in the walls of the individually growing aerial mycelium
+Expressed at the bean stage in the lateral hypodermal seam cells and then throughout embryogenesis and into larval stages
+Expression is detected 20 days after birth and increases gradually up to day 60
+Transcript peaks at G1-S transition, but total protein remains constant throughout the cell cycle. Expressed in multiple tissues during embryogenesis, including neural crest-derived structures
+Expressed throughout development, but expression declines with age (PubMed:30147641). Expressed in regions corresponding to intestinal cells and the body wall muscle quadrant in gastrulating embryos, and this continues throughout all larval stages and into adulthood in most tissues except gonadal cells (PubMed:30147641). In L4 stage larva, expressed in pharyngeal and vulval muscles (PubMed:30147641)
+In early gastrulation, expressed in all three germ layers. In later embryogenesis, expressed in a range of tissues including the central and peripheral nervous systems and the nephogenic mesenchyme
+Expressed during the early stages of erythroid development while expression is very low in reticulocytes and young erythrocytes
+Predominantly expressed at S/G2/M phase
+Not expressed in embryos. Expression starts around day 20
+Confined to styles of stage 13-16 flowers
+High levels detected at 7 dpc
+During myogenesis, there is a marked increase in levels in fully differentiated myotubes compared to undifferentiated myoblasts
+L-ELH greatly increases before egg-laying, while it strongly decreases after egg-laying
+Detected in embryos at 7.5 dpc, but not at 6 dpc
+Strongly expressed in fetal brain but expression decreases from P12 onward. Expressed in postmitotic neurons
+Expression is first detected on 8 dpc and increases until 13.5 dpc, then sharply decreases from day 13 dpc until 18 dpc. Expression is barely detected in newborn brains but increases again after birth. Highly expressed in the retinal neuroblastic layer during the early stages of retinogenesis. Down-regulated during neuronal development. At 14.5 dpc, expressed in the periventricular neural stem cells of the brain
+Expressed in sporozoites (at protein level) (PubMed:34799567). Expressed during the asexual blood stage, including in rings, trophozoites and schizonts (PubMed:33974939). Expressed in gametocytes (PubMed:33974939)
+Preferably expressed in spores
+Expressed throughout development from embryonic to adult stage, highest level seen in early larvae. Isoform A is the most abundant and isoform C is the least
+Strongest expression found in embryonic day 15 dpc compared to postnatal day P1 and adult brain
+Detected in early development between postnatal days 3 (P3) and P8 and decreased from P14 in forebrain and cerebellum
+Expressed throughout development and in adult animals (PubMed:21954162). First expressed in the embryonic BAG neurons (PubMed:30890567)
+Isoforms A and C are maternally and zygotically expressed in embryos. Isoform A reduced between 2-12 hours embryos and then increases. Isoform B is expressed in later embryonic stages. Isoform C has the lowest expression level of the isoforms
+Isoform 1 is detectable by embryonic day 13, whereas isoform 2 is detected postnatally
+In very late pupae and in adults
+Expressed zygotically from the tailbud stage
+Expressed both maternally and zygotically. Continuously expressed from the egg to the tailbud stage (stage 30) with an increase in expression at the early gastrula stage (stage 10)
+Expressed in the somatic gonadal precursor cells, Z1 and Z4, of XO and XX L1 stage larvae (PubMed:14993191). Expression is sexually dimorphic later in larval L1 stage and appears to be gonad-specific (PubMed:14993191)
+At 24 hpf, expression almost entirely restricted to the endothelial cells of the developing vasculature, with high levels in the major head and trunk vessels and also in the intersomitic vessels
+Expression begins during bean stage in hypodermal cells. At the 2-fold stage, also expressed in a few head and tail neurons
+Weakly expressed during vegetative growth and significantly induced at the onset of sporulation
+Becomes detectable 60 hours after imbibition of the seeds and remains constant up to 101 hours after imbibition
+Detectable from a late gastrula stage (10 hpf). Very weakly expressed in the midbrain region at the 14-somite stage. Expression in the midbrain intensifies and extends along the anterior- posterior axis as embryogenesis proceeded. At 2 dpf, strongly expressed in the developing eyes and midbrain region. At 3 dpf, expressed in the retina
+Strong expression in developing brain and spinal cord of the embryo. Also expressed in the myotomal muscle
+Is probably activated at the time of septum formation separating the mother cell from the nascent endospore, (stage II)
+At 9.5 days, expression is detected in branchial arch mesenchyme, forebrain, hindbrain, midbrain, and neural tube. At 12.5 days, is detected in the hindbrain, forebrain, lung, genital eminence, spinal ligaments around vertebrae and ribs, and around the cartilage of ribs and nasal sinuses. Also detected in frontonasal mass, mandibular arch, optic sulcus, spinal ganglia and hind limb bud. At 15.5 days, expression is detected in the ventricular layer of neurons subjacent to the neocortex, around the nasal sinuses, bronchioles of the lung, kidney, and around the vertebrae of the tail. Also seen in the olfactory bulb
+Expressed zygotically. First detected at the beginning of somatogenesis. At the 16-somite stage, restricted to posterior adaxial cells and, in the anterior, to cells adjacent to the neural tube and to ventromedial reigons of the somites. At 24 hours-post-fertilization (hpf), expressed in the ventral rhombomeres, telencephalon and olfactory bulbs. At 48 hpf, expressed in the brain, retina and fin buds
+Expressed both maternally and zygotically. Predominantly in early to middle embryogenesis, in larvae and adult females
+Expressed at the time when separation of neural and epidermal precursors cells occurs. Detected in the neuro-ectoderm of stage 9 embryos. At stage 10/11, accumulates at high levels in the presumptive mesoderm, however, it disappears quickly with the onset of germ band retraction. In eye disk, expression occurs close to, as well as posterior to the morphogenetic furrow. In the wing disk, found in the proneural clusters areas, the dorso-ventral boundary and vein/intervein regions
+Highly expressed in very young leaves and then decreases with leaf age
+Expressed in the hippocampus at late embryonic stages and during the first week after birth. Down-regulated after postnatal day 7
+Expression was widespread throughout the embryonic stages analyzed; 10.5 dpc, 12.5 dpc, 14.5 dpc and 18.5 dpc. At 14.5 dpc, strongest expression was observed in the developing central and peripheral nervous system (CNS and PNS, respectively) and in the olfactory sensory epithelium. In the CNS, the proliferating neuronal precursors in the ventricular zone expressed it more than the postmitotic neurons. At 18.5 dpc, highest expression levels were detected in the mechanosensory hair cells of the inner ear and in the differentiated keratinocytes of the skin
+Expressed at embryonic day 15 in brain and spinal cord. At embryonic day 19 expression accumulates in the hippocampal formation. Prominent expression in the subicular cortex at postnatal days P1, P8 and P15 but then markedly reduced in the adult
+Expressed throughout the central nervous system at larval and adult stages
+Expressed in embryos, larvae and adults (PubMed:21596899). Expression begins in multiple cells in embryos, reaching a maximum in the L1-L2 larval stages (PubMed:21596899). Expressed in the ventral nerve cord VA and VB neurons, but not in the VC neurons (PubMed:21596899)
+Expressed in late primitive-streak stage embryos (7.5 dpc), when hematopoiesis is thought to begin, and the expression is restricted to the hematopoietic lineage in embryo. In adults expression continues to be in the majority of cells from hematopoietic origin, including granulocytes, monocytes and lymphocytes, and is also found in the spermatids of the testis
+Meiosis-specific. Expressed from 3 to 9 hours after induction of sporulation
+Expressed during pollen development and tube growth
+Predominantly expressed in embryos (at protein level) (PubMed:16701565). Expression transiently increases at the L2 larval stage (PubMed:17369820)
+Isoform a and isoform b are expressed both maternally and zygotically. Maternal expression disappears before gastrulation and zygotic expression begins after stage 20 and continues throughout embryogenesis. In contrast, isoform c is only detected from stage 30
+Expressed in proliferating cells. Observed between G1 and mid S phase, decrease toward the end of S phase, and disappear at the S/G2 transition
+Expressed in ovaries and immature oocytes and two cell stage embryos, then, it disappears. It is unstable during the first meiotic division and accumulates only during the second meiotic division
+Expressed more highly in male embryonic day 3 (3 dpc) and 5 dpc whole embryos, paired urogenital system at 7 dpc and gonads at 9 dpc than in females
+Expressed throughout embryonic development at 12.5, 14.5, 16.5 and 18.5 days post coitum (dpc), in cells localized at the apical region of the developing olfactory epithelium (OE) (PubMed:27910949). Expressed transiently in the progenitors of the secretory microvillar cells and Bowman's glands in the OE, expression being abolished by 2 months of age (PubMed:27910949). Also expressed at the canalicular stage, at 15.5 days post coitum (dpc), in the large excretory duct of the developing salivary glands (PubMed:18572159). By the terminal bud stage, just prior to birth, at 17.5 dpc, expressed in a small number of cells in ductal structures of all three major salivary glands (PubMed:18572159). At three weeks of age, expressed in duct cells in the submandibular, sublingual and parotid glands (PubMed:18572159)
+Expressed in the unfertilized egg and throughout the early embryonic stages. Expressed in the neural plate at stage 13. Expressed throughout the eye primordia and cranial ganglia at stage 25. Highly expressed in the differentiated retinal ganglion cell layer at stage 40
+Expressed at high levels in 8.5 day embryos in the mandibular arch while a lower expression is seen in the extraembryonic mesoderm. Expression is abundant at days 8.5 and 9.5 in the developing visceral arches and the splanchnic mesoderm surrounding the gut. Present in the myocardium from days 8.5-12.5. At day 14.5 present in valves and extensively in the ventricular septum
+Expression starts at 3 days and peaks at 5 days. After, expression levels remain constant from 7 to 10 days. During embryogenesis, expressed first at the site of root meristem formation, then in the epidernal and ground tissue, root meristem and suspensor. In the mature embryo, expressed in the vascular primordia throughout the hypocotyl/root axis
+Expressed during embryogenesis (PubMed:19167332, PubMed:24374177, PubMed:28806108, PubMed:20550938, PubMed:24185444, PubMed:26687600). First expressed at the 20 cell stage with expression peaking at the 80-100 cell stage, and decreasing as development continues (PubMed:20550938, PubMed:24185444, PubMed:28806108, PubMed:22767594). Undetectable at the comma stage (PubMed:28806108)
+The first vegfr expressed during development
+Maternally inherited. Detected in oocytes and eggs. Expression declines during early development and is not detected in neurula, tailbud and tadpole embryos
+Up-regulated in embryonic germ cells of the female gonads in an anterior-to-posterior wave from 12.5 dpc to 16.5 dpc. In male gonads, expression is first detected after birth
+Expressed in growing new meristem. Down-regulated in elongating new meristem
+Expressed in the visceral mesoderm of the yolk sac from 9.5 dpc to 15.5 dpc (at protein level) (PubMed:16835393, PubMed:30413363). Expressed in the sclerotome of developing somites and the derivative vertebrae and ribs between 9.5 dpc and 12.5 dpc (PubMed:16835393). Expressed in the rostral perichondrial area and mesenchyme of the limb bud in the prospective arm region and hand plate at 10.5 dpc, proximal mesenchyme expression in the forelimb then decreases between 11.5 dpc and 12.5 dpc until expression is consolidated to the arm regions of the developing limb at 12.5 dpc and forelimb digits at 13.5 dpc (PubMed:16835393). Expressed at variable levels in the prospective forebrain to the hindbrain and all neural tube cell layers from 9.5 dpc to postnatal day 6 (P6) (PubMed:16835393, PubMed:26525805). Expressed in immature oligodendrocyte precursor cells and astrocytes at 15.5 dpc, additionally expressed in precursor and differentiating oligodendrocytes in the neural tube from 18.5 dpc to P6 (PubMed:26525805). Highly expressed in embryonic arterial walls at 13.5 dpc (PubMed:9421502). Low levels are found in the inner ear at 13.5 dpc and in some cells in the thymus at 16.5 dpc (PubMed:9421502). Initially expressed in the hair follicles of the whisker pad vibrissae at 14.5 dpc, expression continues in the hair placode and in hair germ and peg during hair follicle morphogenesis to 18 dpc (PubMed:9421502, PubMed:30638933). Expressed in the newborn hair follicle epithelial sheath, this expression weakens at P15, reexpressed in the hair follicle bulge and secondary germ regions at P22, with expression continuing in the root sheath of the hair follicle at P28 (PubMed:30638933). Expressed in trophoblast giant cells of the spongiotrophoblast and labyrinth layers of the placenta at 15.5 dpc (PubMed:16835393). Expressed in DN1d cells, a subset of DN1 precursor thymocytes, from 16 dpc onwards (PubMed:30413363). Expressed in the tracheal epithelium below the vocal cord at 18 dpc (PubMed:9421502). Expression is transiently increased during brown adipocyte differentiation (PubMed:27923061)
+At 15.5 dpc, expressed in skeletal muscle. Down-regulated in adult skeletal muscle
+Uniformly expressed at all developmental stages
+Is expressed temporarily during the early stages of retinoic acid-induced differentiation of embryonal carcinoma cells and during the mid-gestation period of mouse embryogenesis. In late embryos and in adults expression is restricted to the kidney
+Found only in procyclic parasites
+Levels decrease during S phase
+Expression begins at the early-mid blastula stage. Levels are highest during the blastula and gastrula stages, after which levels decreases until somite segregation. At later developmental stages, expressed at a slightly lower level than foxi1-B
+Expression initiated at step 9 of spermatid development and peaked between steps 10-13. Expression decreased abruptly at step 14 and was undetectable after step 15
+In the male gonad, barely detected at 13.5 dpc or at birth, detected weakly on postnatal day 14 and maximally expressed in the 4- or 7-week-old mouse testis but not detected in the epididymis of the 7-week-old mouse (at protein level). In the female gonad, low levels detected at birth (at protein level). In the adult testis, present predominantly in pachytene spermatocytes and round spermatids but not in spermatogonia, preleptotene spermatocytes or elongating spermatids (at protein level)
+Early expressed in the whole plant. Detected in the leaves of 2 and 4 weeks old rosettes, but not in 6-weeks-old rosettes. Detected specifically in roots from the mature plant (6-weeks old)
+At stage 11, expressed in the medial sites of the embryonic right and left coelom, as well as in the medial region of the forming somites. Between stages 14 and 16, expression in the presumptive wing field, with strongest expression at stage 15. At stage 17, a faint expression is detected in the posterior region of the nascent limb bud. Expressed in the ocular surface ectoderm, including the corneal epithelium, starting from the onset of the lens vesicle closing at stage 16
+In 9.5 dpc embryos, expressed in the rhombencephalon, metencephalon, and in the cephalic mesoderm surround the optic vesicle. By 12.5 dpc, expression continues in the mesenchyme and also begins in subsets of cells in the neuroretina, becoming expressed in the retinal inner neuroblast layers by 16.5 dpc. Expressed in developing bipolar cells during retinal development starting at postnatal day 5, and expressed in a subset of cone bipolar cells in the mature retina. Also expressed along the spinal cord, in the ventricular layer, in motor neurons and in the proximal limb buds during embryonic development. Expressed in the developing heart in the endocardium that lines the heart chambers
+Detected throughout embryonic development. In late gastrula and neurula stages, mainly expressed in head and dorsolateral mesoderm, and in eye, cranial neural crest and somites at later stages
+Detected at the 4- to 32-cell stage, suggesting it is expressed maternally
+Expressed in the yolk sacs at vascular endothelial cells at 7.5 dpc. Expressed in the glial sling (GS) at the cortico-septal boundary at 17.5 dpc (at protein level)
+Expressed in egg and embryo (at protein level)
+In testis, expression strongly increases at P22
+Expressed gradually during oogenesis. First expressed in stage I-II oocytes at a low level. Strongly expressed during stage III-IV, and thereafter for the remainder of oogenesis
+Low levels are found at postnatal day 4. Levels increase from postnatal day 7 to postnatal day 17. Levels decrease and remain low in the adult
+Expressed from early embryogenesis and throughout all developmental stages (at protein level) (PubMed:22616817). Expressed in body wall muscle in embryos, young larvae and adults (at protein level) (PubMed:22616817)
+Expressed in brain at 10.5 dpc and thereafter
+Expressed in the somitic myotome from 8.75 dpc mouse embryos onwards and later on in skeletal muscle but not in the heart. Additional expression domains during development are detected in the pharyngeal pouches and clefts starting at 8.0 dpc as well as in the cranial pharynx and in Rathkes pouch
+At 10.5 dpc, strongly expressed in the developing neural tube and optic vesicle, as well as in the branchial arches and kidney (PubMed:17920587). In the developing kidney, detected in the mesonephrotic tubules (PubMed:17920587). At 11.5 dpc, expressed along the entire cranial-caudal length of the developing neural tube, including the anterior forebrain and the posterior spinal cord (PubMed:17920587). Always restricted to the ventricular layer, where proliferative cells are located (PubMed:17920587). Conversely, not detected in postmitotic neural compartments (PubMed:17920587). In the developing lung, at 11.5 dpc, expressed in the internal endodermal layer and in particular in the nascent bronchial tips (PubMed:17920587). At 12.5 dpc, expressed in the optic vesicle, detected mainly in the retinal layer (PubMed:17920587). The retinal pigment epithelium shows only background levels (PubMed:17920587). At 15.5 dpc expressed at the basolateral side of the plasma membrane in brain, spinal cord, kidney, testis, intestine, skin, and muscles (PubMed:17920587)
+Detected in mature brain, but not in fetal brain
+First detectable at the neural plate stage in the stomodeal-hypophyseal (pituitary) anlage and in the neural plate. At later stages it persists in the pituitary and pineal, retina, hindbrain and spinal cord
+Expression appears in neurons of the hippocampus during the first 2 weeks after birth (at protein level)
+In the germarium, it begins to accumulate preferentially within the future oocyte shortly after formation of the 16-cell cyst. In midoogenesis, it can be seen transiently at the posterior edge of the oocyte, but by stage 9 assumes an anterior localization, and appears to be more concentrated at the dorsal side of the oocyte, above the oocyte nucleus. This pattern of localization is similar to that seen for grk mRNA and protein, though not tightly restricted to the dorsal side
+Throughout oogenesis and in mature eggs. Constant levels during early embryogenesis, but decrease at 8h. After midblastula transition, the steady state level increases substantially
+Expressed from early prenatal stages, as early as 7 dpc and increased thereafter
+Expressed during the estrus cycle. Expression is maximum at proestrus and moderate at estrus. Not expressed in diestrus and metaestrus phases
+Isoform A and isoform B are expressed both maternally and zygotically. Zygotically expressed throughout embryogenesis, until second larval instar. Isoform A is more highly expressed than isoform B
+Expressed in the chicken embryo
+Peak expression observed in mid to late log phase
+Expressed in haploid male gametophytes during pollen maturation and in diploid zygotic embryos and endosperm after pollination
+Not expressed in embryos
+Not detected in somites which give rise to skeletal muscle at 10.5 dpc (at protein level). Expressed in skeletal muscle of the tongue, diaphragm and axial muscles from 14.5 through 17.5 dpc (at protein level). Not detected in limb buds (at protein level). Overall increase by up to 10-12-fold in vascular and uterine smooth muscle during pregnancy (at protein level). At day 13 of pregnancy, expression increases in striated muscle by 2.5-fold compared with non-pregnant mice, and by about 2-fold over levels expressed in males (at protein level). At the same time, dramatically increased in myometrial cells of the uterus, in the endometrial layer and in aortal smooth muscle. Steadily declines through parturition and the onset of lactation (at protein level)
+Expressed throughout development and in adult animals, with high expression in embryos and in dividing cells (at protein level)
+Expressed in skeletal myocytes with increasing expression during differentiation and in the gastrocnemius skeletal muscle in newborn and at higher levels in 10 days old mice (at protein level)
+Up-regulated in senescing leaves
+Appeared in the brain of 16 days-old embryos and was maintained during the subsequent developmental stages
+Present at all developmental stages
+Isoform 2 is not detected in proliferating myoblasts, but it appears immediately after myoblast fusion and its amount continues to rise during myotube growth and maturation reaching its highest level at day 9 through day 10, when mature differentiated myotubes appear in cell culture. Isoform 1 expression is down-regulated during myodifferentiation in culture and it is completely displaced by isoform 2 in mature differentiated myotubes
+Detected in the dorsal primitive streak region at 8.5 dpc. Detected in the tailbud region and in the developing central nervous system (CNS) at 9.5 dpc
+During the hair cycle, expression is down-regulated at the first telogen stage and is up-regulated at the secondary anagen stage
+Expressed from the early gastrula stage onwards
+First detected in early gastrula stage embryos. Abundant at the neurula stage, becoming less abundant at later stages
+Expressed in the tachyzoite stage
+Expressed during development in embryonic stages 8.5 dpc, 9.5 dpc, 12.5 dpc and 19 dpc
+Expressed soon after the formation of the asymmetric septum during sporulation. Expression commences about 2 hours after the onset of sporulation. Assembly around the developing forespore commences at the time of polar division and seems to continue after engulfment of the forespore is complete. Remains present throughout the late stages of morphogenesis and during this accumulation process preferentially collects on the mother cell side of the engulfed forespore, but eventually is deposited equally all around the forespore
+Expressed in the somites at stage 19 onwards. Expressed in the developing hindbrain between neural plate at stage 32. Expressed in the ventral blood islands from stage 22 until stage 28. Expressed in the condensing pronephros at stage 24. Expressed in the pronephric tubules at stage 33. Expressed in the presumptive lens-forming ectoderm (PLE) at stage 22 and during lens formation. Expressed in the invaginating placode at stage 28. Expressed in lens epithelia at stage 33. Expressed in the rhombencephalon at least until stage 40. Expressed in the olfactory bulb and the thalamus at stage 43. Expressed in the neural crest cells
+Highly expressed in Malpighian tubule primordia from stage late 11 to 13. Expressed in hindgut at stage 13. After stage 14, ubiquitously expressed at low levels
+Expressed in embryos from the initiation of germination
+Expressed broadly in the spinal cord, including the ventral portion of the ventricular zone, and motor neurons. Expressed also in the dorsal root ganglion and boundary cap cells at dorsal and ventral roots. In the early embryonic brain, is first expressed in the prosencephalon and the ventral mesencephalon, and later in the telencephalon, the rostral part of the mesencephalon and some parts of the hindbrain. Expressed also in the ventral part of the neural retina and trigeminal and facial nerves
+Expressed in response to blood meal throughout all developmental stages including larva, nymph and adult. Slightly expressed in unfed ticks. The expression starts to increase on the first day of feeding and reaches the maximum on the third day. The level remains stable until full engorgement
+Larvae, pupae and adults
+Detected in the earliest phase of neurogenesis in brain, and expression is greatly increased concomitant with axon extension and synaptogenesis
+Expressed 3 days after flowering, decreases at 8 days after flowering and then remains constant
+Detected throughout embryogenesis, from 7 dpc to 17 dpc
+Expressed in developing fruit during the enlargement stage
+Expressed at the early stages of embryo development, up to the early heart stage
+At the 10-somite stage, barely expressed in the paraxial mesoderm. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit within rhombomere 7
+Expressed in the 7.5 dpc embryos
+Expressed in chondrogenic tissues in advance of chondrocyte differentiation. Expressed early in embryogenesis at 9.5 days both in the cranial mesenchyme destined for the chondrocranium, and the sclerotome of the somites, and at 12.5 days in the primordia of the hyoid and the laryngeal cartilage. Detected in all the chondrogenic tissues of the axial and appendicular skeleton until the onset of endochondral ossification. Expression also observed in non-chondrogenic tissues such as the notochord. Also expressed much later in the tail tendon, at 16.5-18.5 days. Transiently expressed in the heart at 9.5-12.5 days, the epidermis at 10.5-14.5 days, the calvarial mesenchyme at 12.5-16.5 days, the inner ear at 14.5 days and the fetal brain from 9.5-14.5 days. Within the neural tube, expression is localized to the proliferative ventricular cells of the forebrain and midbrain of 9.5-10.5 day embryos, and subsequently, restricted to the rhombencephalic basal plate, the ventricular layer of the hindbrain and the cervical spinal cord
+Expressed in liver of pre-laying and egg-laying hens throughout sexual maturation. Expression increases gradually from 13 weeks of age reaching its maximum at 15 weeks of age (pre-laying hens). A significant decrease in expression is observed in 41-week-old hens (egg-laying), a level that is significantly lower than that measured initially in 13-week-old pullets
+Accumulates progressively during seedling growth (PubMed:33324437). Expressed during callus formation (PubMed:29923261)
+Expressed at relatively high levels in vegetative cells. Up-regulated at the 2 hour time point. The expression goes down until the 8th hour of development and then goes up at 14 to 16 hours
+First expression detected on embryonic day 11.5
+Increasing levels of expression observed in developing ovaries, floral shoots and roots. Levels decrease with maturation
+Abundantly expressed in zygotic embryos 1 and 2 days after fertilization
+Expressed at 8 dpc. In brain, expression increases between 14 dpc and 16 dpc, reaches a plateau at 18 dpc, and subsequently decreases
+Up-regulated in the leaves during tuberization
+Expressed in heart of 25 and 17 weeks embryos
+Expression detected between 9.5 and 11.5 dpc in the developing neural tube. Was also expressed throughout the neuroepithelium of the developing central nervous system between 10. 5 and 12.5 dpc at 14.5 dpc, the expression became restricted to the neopallial layer of the cortex. At 12.5 dpc, expression was evident in nonneural tissues such as the developing dermis and mesenchyme surrounding the otic and nasal placodes. Expression was also detected in the developing cardiac valves, limb and developing kidney
+Expressed in the vegetative cells, decreases in the aggregating stage, increases in the mid-developmental stage and decreases again in subsequent stages
+Expressed both maternally and zygotically. Abundant in embryos and adults, low levels in larva and pupae. Isoform 1a, isoform 2a and isoform 2b are constitutively expressed at high levels and isoform 2c at low levels in embryos and adults
+Expressed in eggs and early stage embryos. Strong expression is maintained until stage 8
+High expression early in flower development and then declines as the corolla becomes fully pigmented and opened
+Expressed in the presumptive ciliary body during development
+First expressed post-fertilization and expression continues throughout embryogenesis to adulthood (PubMed:10772806). More highly expressed in embryos and L1 to L3 stage larvae than L4 larva and adults (PubMed:10772806). Highly expressed in hyp8-11 cells in the male tail tip during male tail tip morphogenesis but ceases by the late L4 larval stage of development (PubMed:21408209)
+Increases during lens maturation (at protein level)
+Highly expressed during early development, showing high levels in the first postnatal days, followed by a decrease toward adulthood
+Expressed in epidermal cells during the secretion of preecdysial larval and pupal cuticles. Restricted to a short part of the intersegmental regions after pupal ecdysis
+First expressed at the 1-2 somite stage. By the 3-4 somite stage, the anterior expression limit in the developing hindbrain is at the rhombomere 5/6 boundary, and this is maintained until the 20 somite stage. By 30 hours post-fertilization, there is also limited expression within rhombomere 5
+Expression increases in a subset of vulva precursor cells during middle and late L4 larval stage
+Expression increases during grain development
+Expressed at low levels from early embryos to adults; maximal expression in third instar larvae
+Expressed in fetal thymus, liver and kidney
+Is expressed throughout the embryonic central nervous system from presomite stages and in neuron-rich areas of the brain throughout postnatal development, as well as in many other tissues
+In 8 day old mice, before the onset of hearing, detected in membranes of the stria vascularis and in most cells of the organ of Corti. At P14, when the organ of Corti has matured, expression is no longer detected in hair cells and the stria, but is restricted to Deiters' cells that are supporting outer hair cells and to phalangeal cells enveloping the inner hair cells
+In the developing brain, maintained expression from 16 dpc to postnatal day 14. Levels decrease between postnatal day 28 and postnatal day 52 and increase again with further aging up to 156 days old
+Induced during meiosis
+Expressed at relatively high levels in fetal lung, liver, spleen and kidney with lower expression levels detected in heart, thymus and brain
+Expressed in the terminal bulb of the pharynx and the posterior of the intestine throughout development (at protein level) (PubMed:34994689). Expressed in the arcade cells of the pharynx in embryos and in L1 stage larvae (at protein level) (PubMed:34994689)
+Expression is low at 20, 22 and 24 days after birth but has increased by day 60
+In flowers, mostly present in anthers, stigmatic papillae, gynoecium (apical part) and filaments, and, barely in sepals (at protein level). In developing siliques, localized in the apical part and the abscission zone. In seedlings, expressed in cotyledons, hypocotyls, and root tip. Accumulates slowly in leaves as they mature, in the mesophyll and the cells that surround the vascular bundles
+Expressed in early embryo and, during later stages of embryogenesis, in epithelial cells, body wall muscle, germline and mature sperm
+During flower development, expressed in sepals, stamens and siliques. In seeds, confined to the connecting site of the funiculus. In seedlings, expressed in cotyledons and hypocotyls. Restricted progressively to vascular tissues as plants become older
+Expressed in germinating embryos
+Preferential expressed in epithelial cells. In the kidney, expression was seen in both the epithelium derived from the ureteric tree and the mesenchyme-derived epithelium. In other tissues of 13-day-old embryos, expression was also confined to the epithelium. In nervous tissues, mainly expressed in the olfactory epithelium and walls of the lateral ventricle. Weak expression was seen in the heart
+No expression in females or embryos (PubMed:3135120, PubMed:20458515). Expression levels are highest in male adults with little to no expression until the late pupal stages (PubMed:3135120, PubMed:20458515)
+Levels increase in early stationary phase
+Expressed widely during larval and adult stages
+Expressed in the islet-like cells of the developing pancreas and epithelial cells of the duodenum from gestational weeks 8 to 20 (at protein level)
+Expressed during ventral nerve cord development in the embryo and in larval imaginal disks. Expressed in a dorsal-ventral pattern in the eye-antennal disk
+At 8.5 dpc expressed in the developing cardiac region. At 10.5 dpc expression is restricted to the cardiac region and myotome of the somites. Pre-natal expression is muscle-specific
+Expressed in embryos from 10.5. to 14.5 dpc (PubMed:20887964, PubMed:29263200). In 10.5-12.5 dpc embryos, detected in the vesicles of the heart, branchial arches, mesonephric duct, head mesenchyme, developing eye and forebrain (PubMed:29263200). At 12.5 and 14.5 dpc, high levels of expression are particularly noteworthy in the developing cortex and the olfactory bulb (PubMed:20887964, PubMed:29263200)
+From embryonic day (E) 17.5 onward in the developing mouse thyroid and lung
+Isoform 2 is expressed in fetal testis
+Expressed primarily in the developing neural tube at 10.5 dpc
+Expression in the inner hair cells of the ear is lost at the onset of hearing, around P12. This correlates with a loss of sensitivity of these cells to cholinergic stimuli
+Expressed in embryonic day-15 eye, brain, skeletal muscle, heart and intestine, but virtually absent from embryonic day-15 liver
+Embryo, blastula stage. Highest activity at 12.5 hours embryo stage
+Mainly expressed at the brain surface with a slight expression in the brain parenchyma at postnatal day 1, 7, and 14. At the stage of postnatal day 28, mainly expressed in the parenchyma
+At 15.0 dpc, expressed in brain, liver, thymus, lung, intestinal epithelium and follicles of the whiskers
+Highly expressed in tachyzoites. Detected at low levels in bradyzoites and sporozoites
+In young seedlings, expressed predominantly in cotyledons, at the top of the hypocotyl, and in the root tip, regardless of light conditions. In older seedlings, confined to unexpanded cotyledons of dark-grown seedlings
+Expressed both maternally and zygotically throughout development in oocytes, eggs, embryos and adults. Expression increases between oogenesis stages III and VI
+Expressed maternally and zygotically. Expressed in both egg and central cell before fertilization, and in the embryo and endosperm after fertilization
+Expression is cell cycle-dependent, with highest levels in G2/M phase and lowest in S
+Expressed in pyramidal neurons of the hippocampus at 18 dpc
+Expressed in embryos and adults. May be expressed in oocytes
+First expressed at stage 10.5 in the involuting marginal zone (IMZ) along a dorsal-high ventral-low gradient and, by stage 14 in cells of the circumblastoporal collar
+Up-regulated during chloroplast to chromoplast transition stage
+Maximum levels during G(1) phase. Levels decrease through S and G(2) phases
+First detected at the onset of gastrulation in a band at the blastoderm margin (PubMed:16216239, PubMed:17360770). Ubiquitous during gastrulation, somatogenesis and at 48 hpf (PubMed:16943304). During gastrulation, detected at the hypoblast of the dorsal midline and in dorsal forerunner cells that form a ciliated Kupffer's vesicle later on (PubMed:16216239, PubMed:17360770, PubMed:26432887). Ubiquitous during early somite stages, with high levels of expression in Kupffer's vesicle (PubMed:16216239, PubMed:17360770). At subsequent stages, detected in pronephric duct primordia and neural floorplate (PubMed:16216239, PubMed:16943304, PubMed:17360770, PubMed:26432887). Highly expressed in brain at 24 hpf (PubMed:16216239). At 3 dpf, detected at pharyngeal arches and the pectoral fin bud (PubMed:16216239)
+In seedlings, first observed at the hypocotyl/root junction but later confined to the hypocotyl. In flowers, restricted to the stigma of mature flowers. In siliques, confined to the abscission zone
+Very low levels detected in 0-6 hour embryos with expression up-regulated after 12 hours of embryogenesis and persisting into adult stages (at protein level)
+Degraded by the APC/C complex during G1 phase and reaccumulates at the G1/S phase transition
+Detected in pachytene spermatocytes and has increased expression in early and late spermatids
+Expressed both maternally and zygotically. Expression increases between 1 dpf and 2 dpf when the exocrine pancreas starts to develop and is highest between 2 dpf and 5 dpf. Starts to express in the pancreatic area at 33 hpf. Later in development, the strongest domain of expression appears in the pancreas. Cells expressing are located about 1 somite anterior to the cluster of preproinsulin-positive cells, just before exocrine specification begins. By 36 hpf, expressing cells start to contact the preproinsulinpositive cells as a result of gut rotation. These expressing cells continue to grow posteriorly to form a typical pancreas-like shape at 3 dpf. From 33 hpf to 3 dpf, there is no overlap between expressing cells and preproinsulinpositive cells, indicating that expression is excluded from endocrine cells. Conversely, expression completely overlaps with trypsin expression at 3 dpf
+Detected in embryos at 7, 11, 15, and 17 dpc. At 16 dpc, predominantly expressed in the central nervous system (at protein level). Strongly up-regulated during brain development from 17 dpc up to at least postnatal days 14 (at protein level). In N2a neuroblastoma cell line model and in primary cultures of hippocampal neurons, up-regulated during neuronal differentiation induced by serum reduction (at protein level)
+The parasporal crystal protein is produced during sporulation and accumulates as a spore inclusion; crystals are separated from the forespores by a branch of the exosporium across the cell. The matrix of the paraspore is dissolved within 15 minutes following C.quinquefasciatus larvae feeding
+Expressed in the embryo in sensory neurons with 6-fold symmetry, probably the inner labial neurons (PubMed:16584723). Expressed between comma and 3-fold stage, diminishing afterwards and absent in larval stages and adults (PubMed:16584723). Expressed in all dopaminergic neurons throughout postembryonic stages (PubMed:19287374). Expressed in a few cells in the pharynx at the 2-fold stage (PubMed:16584723)
+Expressed in the inner and outer pericarps of developing fruit from 20 to 49 days after flowering (DAF), and expression decreases as the fruit ripens
+Its expression is closely related to cellular differentiation in both normal and malignant squamous cells
+Expressed early in development in the form of precocious cell aggregation. Expressed at a significant level during vegetative growth and peaks at 8-16 hours of development. Even at its peak, the level of expression is low
+Expression first detected in wpf (week post-fertilization) 11 and is highest in wpf 22
+Expressed during early neurogenesis
+At 17.5 dpc, predominantly expressed in the central nervous system, throughout the forebrain, midbrain, hindbrain, and the spinal cord. Expressed in the developing neocortex and at low levels in the ventricular zone, especially in the outer neuroblastic layer. In the developing retina, strongly expressed in the postmitotic inner neuroblastic layer. Also found in the developing ovary and, to a lower extent, throughout the kidney
+Earliest expression is at 8 hours post fertilization (hpf) in the midline and limited to the notochord precursor by 10 hpf (PubMed:11429297). By 11 hpf, expressed in the prospective midbrain and hindbrain (PubMed:11429297). By 14 hpf, expression is highest in rhombomere 2 (r2) of the hindbrain, lower in r1 and r3 and even lower in r4 and r5 (PubMed:20408909). By 17 hpf, expression in the notochord is restricted to a region anterior to the chordoneural hinge (CNH) (PubMed:11429297). Expressed in the pectoral fins at 36 hpf and at a much lower level at 48 hpf (PubMed:20408909). Expressed in the diencephalon above the ventral flexure, midbrain and hindbrain at 48 hpf (PubMed:11429297). Expressed at the onset of chondrogenesis, in the developing hyoid joint, at 53 hpf, overlapping with irx7 (PubMed:26555055). Also expressed in a zone connecting the nascent hyomandibular and symplectic cartilages (PubMed:26555055). By 72 hpf, expression is further restricted to cells within and surrounding the hyoid joint, with additional expression along the posterior margin of the hyoid arch (PubMed:26555055)
+Expressed in the earliest embryonic hair placodes. In adult hair follicles, present in a region directly above the follicle bulge. Specifically present in prenatal cells establishing the hair follicle, sebaceous gland and interfollicular epidermis. Postnatally, present in cells generating sebaceous gland and interfollicular epidermis (PubMed:20223988). During limb development, at 14.5 dpc, expressed in the ectoderm overlying the limb buds and at the apical ectodermal ridge. In the developing lungs, at 14.5 dpc, expressed in smooth muscle cells (PubMed:29769720)
+Expressed at high levels in the developing heart, with high levels at 9.5 dpc that progressively decrease until 11.5 dpc
+During vegetative phase expressed in young leaves and apical meristem until early stage of bolting. Early in development of the inflorescence present in the coflorescence and flower primordia but not in the main apical meristem. Present throughout the floral meristem during early stages of flower development. Later disappears prior to emergence of sepal primordia
+Expressed at the embryonic stage
+Expressed in axons of early differentiating neurons as well as in the adult nervous system
+Maternally supplied mRNAs are initially observed (PubMed:26095893). Ubiquitous zygotic expression is visible at 3 hours post-fertilization/hpf and strongly increases from 8 hpf to 48 hpf (PubMed:26095893). From 10 hpf, the expression progressively concentrates in the anterior neural plate (PubMed:26095893). From 18 hpf through 48 hpf, expression is abundant in the forebrain, especially in the diencephalon (PubMed:26095893)
+Expressed at the promastigote and amastigote stages
+In embryonic brain, first detected at day 14 and in postnatal brain, levels increase in day 1 and day 18. Levels decrease significantly in adults
+Detected in germinal vesicle (GV) stage oocytes and in embryos up to the 8-cell stage, but not in morula or blastocysts
+Expressed in the limb, tail and intestine by T3 during metamorphosis
+In the heart stage embryo, expressed in the developing vasculature and the apical epidermal layer. At the torpedo stage expressed in the developing vasculature of the root, hypocotyl and cotyledons, as well as in the L1 layer of the presumptive shoot apical meristem and the adaxial epidermis of the developing cotyledons. In flowers, the expression is first restricted to the central outer layers of flower primordia, but later expands toward the base of gynoecia, becoming limited to two cell files along the meristematic medial ridge
+Prominently detected in the cytoplasmic lobe of step 15-18 spermatids and diminishes in step 19 just before spermiation. In the spermatid tail, it increases from step 15 to 19 and is confined to the principal piece. First detected scattered throughout the cytoplasm of the axoneme in step 14-15 spermatids, but begins to be incorporated by step 16 into the FS. During steps 17-18, it increases over the ribs and columns of the assembled FS. It peaks in step 19 and remains in the FS of epididymal spermatozoa
+Highly expressed in endometrial epithelial cells in proliferative phase of the menstrual cycle. Levels decrease approximately 10-fold in the secretory phase. Virtually undetectable in samples from postmenopausal women
+Expression in dentate granule cells of the hippocampus at postnatal day P5, with disappearing expression in dentate granule cells as early as P14
+Expressed at low levels in the bloodstream form (at protein level) (PubMed:31743541, PubMed:32532821). Expressed in the procyclic form (PubMed:31743541)
+Expressed in all fetal tissues tested
+Expression increases markedly during activation of blood and skin DC (Langerhans cells), but is diminished in terminally differentiated tonsil DC
+Expressed in tooth from 13 dpc, the bud stage. Continues to be expressed even when thick enamel is formed
+Not detected in fetal, newborn or 7-day-old testis. Present in 21-day-old and adult testes. Levels are 10-fold higher in adult testis than in testis of 21-day-old animals
+Expressed in the developing fetal lung epithelium (at protein level)
+Detected from 5.5 dpc in parietal trophoblast giant cells (PubMed:18776147, PubMed:10885754). Detected at 8.5 dpc in placenta, and shows increased expression level from 13.5 to 19.5 dpc (PubMed:11829493)
+Weakly detected in the dorsal forerunner cells at 80% epiboly to bud stages. At the 10-somite stage, strong expression is detected in the otic placodes, Kupffer's vesicles, and floor plate. Later, at 24 h post-fertilization, is mainly expressed in organs rich in motile cilia, including otic vesicles, pronephric ducts, and floor plates. At later stages, displays a ubiquitous expression pattern
+No expression at 1 day old. Expressed at 7 days old, increased expression at 14 and 56 days old
+Expressed in prespore and in mature spores, and at low levels in vegetative cells. Accumulates between 2 and 10 hours of development and decreases thereafter (at protein level)
+Detected in early lateral dermatome and in all dermatome derivatives. Expressed at the basement membrane of embryonic skin and developing hair follicles. At 16.5 dpc, present in lung epithelium, and developing oral and tooth germ epithelia (at protein level)
+Highly expressed in developing and regenerating muscles, at the time of myofiber diversification
+Is up-regulated in primary spermatocytes (expression overlapping with the genome-wide erasure of methylation) to become silenced on activation of CTCF in post-meiotic germline cells (expression corresponding to DNA remethylation)
+Expressed in the 2-cell-stage embryo, followed by a strong expression at 8-cell-stage
+At 15.5 dpc, detected in axons extending from habenula nucleus explants (at protein level). Expressed in the habenula nucleus at 13.5 dpc and 15.5 dpc, and in the prosomere 2 adjacent to the fasciculus retroflexus at 15.5 dpc
+First observed in floral meristem and early anther primordia. Later detected in archesporial cells. From stage 4 to early stage 5, weakly expressed in precursors of the middle layer, tapetum and meiocytes. Strongly expressed in the tapetum from late anther stage 5 to early stage 6, and at a lower level in meiocytes
+Expressed in embryos (at protein level) (PubMed:9153213, PubMed:3095323). Expressed at low level in eggs (PubMed:10930405). Levels increase in early embryonic stages followed by a decrease in late embryos and a moderate increase in first-instar larvae (PubMed:10930405)
+From the third-instar larval stage to the adult stage
+Expressed in embryos (at protein level) (PubMed:15175013). Expressed throughout development, with highest levels of expression in 0-8 hour embryos and adult females (PubMed:16507570)
+Expressed in chondrocytes during all stages (PubMed:9061001). Highest levels during the prehypertrophic stage (PubMed:9061001)
+Highly expressed in L1 stage larvae
+Expressed throughout embryogenesis, with expression rising after neurulation
+Detected in fetal chondrocytes and osteoclasts at 19 dpc and 21 dpc, respectively (at protein level)
+Expressed in all developmental stages, increasing gradually from embryo to larval L4 stage, decreasing and stabilizing in adult stage (PubMed:18680432). Expressed in intestine in all larval and adult stages, and in a few neuronal and hypodermal cells (PubMed:18680432)
+Expressed in the first stage of developing seeds
+Accumulates during ripening
+Fetal- and puberty-specific
+Expressed both maternally and zygotically. Expressed in all cells of early embryos. In late embryos and L1 larva, it is weakly expressed in somatic cells, while it is expressed at intermediate levels in the primordial germ cells Z2 and Z3
+Expression initiates at 11 dpc in the central optic cup and is detected in retinal progenitor cells until birth (PubMed:9806930). In addition to the eye, only expressed in the developing tenth cranial ganglion between 13.5 dpc and 15.5 dpc (PubMed:9806930). Expressed in the retina and faintly expressed in the caudal rhombic lip and rostral rhombic lip at 12.5 dpc (PubMed:17977745). Expressed in the presumptive ventral cochlear nucleus and in initial axons emerging from the cochlear nucleus and extending via the trapezoid body towards the ipsilateral lateral superior olive at 14.5 dpc (PubMed:17977745). Expressed in the cochlear duct epithelium between 14.5 dpc and 17.5 dpc (PubMed:17977745). Expressed in the retina at 16.5 dpc (PubMed:17977745). Expressed in the cochlear nucleus at 16.5 dpc and P8 (PubMed:17977745). Abundantly expressed in the ventral cochlear nucleus and axons originating from these cells that form branches in the lateral superior olive at 18.5dpc (PubMed:17977745)
+Transcription is restricted to the sporulation phase
+Transcribed in the stolon tip during the early stages of tuberization. Maximum expression was in non-swelling stolon tips from stage b, and level declined as the tuber increased in size
+Probable target of the anaphase promoting complex/cyclosome (APC/C) which regulates its level in the cell during the mitotic cell cycle. Highly expressed during interphase and early mitosis. Expression decreases during anaphase to become undetectable during telophase and cytokinesis. Expressed in cells destined for multiciliated cell differentiation, its expression is very weak in fully differentiated ciliated respiratory cells (PubMed:25048963)
+At 6.5 dpc specifically expressed in the cells of the visceral endoderm
+In the CNS it accumulates progressively between embryonic day 14 and postnatal day 10, remains high until postnatal day 30, then decreases into adulthood
+Expressed at all stages of development, from seedlings to adult reproductive phase
+Expression levels are low during larval feeding stages and increase dramatically at the start of the wandering stage
+First detected in gastrula. Detected throughout the embryo. Detected in adult
+Appears at later stages of developing flowers, in the vasculature of the style, and in the apical parts of the stamen filaments and petals
+Expression increases in developing seeds and decreases during seed germination
+Widely expressed in embryos, but particularly in intestinal precursor cells (at protein level)
+Expressed ubiquitously in early embryo. At the comma stage and at later embryonic stages expression is mainly restricted to the anterior region of the embryo and to the ventral cord. At the 1.5-fold embryonic stage, expression starts in pharynx and in several head and tail neurons and is maintained in adults. During L1 larval stage, expressed in ALM and PLM neurons and later in PVD and AVM neurons
+Highly expressed in the brain at 14.5 dpc especially in the cortex ventricular zone and hindbrain
+In larvae, expressed in a punctate pattern along the CNS axons (at protein level) (PubMed:23892553). Expressed in larval body wall muscles and in the synaptic boutons (PubMed:24124519). In embryos, expressed in the CNS midline and muscles (PubMed:19018662)
+Expression is maximal at stages 24-31, then begins to decline. Expression is absent by stage 37. Does not appear to be expressed in adults
+Expression is increased to a peak level just before pupal ecdysis
+Expressed maternally and throughout embryogenesis. Expressed in the rostral neuroectoderm and at low levels in the notochord following gastrulation. Expressed throughout the developing brain during somitogenesis
+Detected in the whole seedling except the hypocotyl (PubMed:29390074). Observed in all floral organs, including sepals, petals, filaments, anther walls, mature pollen grains, pollen tubes and young siliques (PubMed:29390074). Highly expressed in the anther tapetum at uninucleate and bicellular stages (PubMed:29390074)
+Expressed in young adults but not in larvae (PubMed:17369820). Expressed in pharyngeal muscles and in body wall muscles in L2 and L4 larvae, respectively (PubMed:15294159)
+During embryo development, expressed throughout embryos at the globular, heart, torpedo and bent-cotyledon stages
+Expressed during early seedling development in the micropylar endosperm as well as in the developing root. Also expressed in the mature root system, particularly at the junction between primary and lateral roots. Expressed in the shoot vasculature in both external and internal phloem including sieve elements and companion cells, and also in the vascular (xylem and phloem) parenchyma in 3-week old plants
+Main catalase activity in conidia, during germination of conidia, and initial growth
+Expressed maternally in oocytes
+Isoform L and isoform S are expressed in brain from 14 dpc to adulthood, with highest levels in the perinatal period. At embryonic stages, isoform L seems to be excluded from cerebellum
+Expressed at late stages of spermatogenesis, from late to maturing spermatids (at protein level)
+RAD51 is cell cycle regulated, peaking around the G1-to-S transition
+Expressed in the developing somites and the ventricles of the heart. Expressed in the otic vesicles between 8.5 dpc and 10.5 dpc. Expressed in the myocardium of the ventricles at 9.5 dpc and in the atrioventricular cushions from 9.5 to 12.5 dpc. At 10.5 dpc, strongly expressed in the spinal nerves, the cranial ganglia and the telencephalon. At 11.5 dpc, expressed in the craniofacial region of the distal part of the maxillary arch, along the rostral mandibular arch and surrounding the lateral nasal processes. Expressed in the midbrain-hindbrain boundary and the posterior edge of the hand- and foot-paddle. Expressed in the mediodorsal region of the telencephalon and the ventricular zone of the ventral spinal cord at 12 dpc, then in the ventral region of the telencephalon and the cortical plate at 15 dpc. Expression in the heart is limited to the compact myocardial layer at 17.5 dpc. Also expressed in the developing retina up to P5, at which point expression decreases
+Expressed in embryos from the 2-cell stage until morphogenesis. May also be maternally expressed. Not expressed during mitosis
+Expressed in the inner integument throughout ovule development
+In the male, it appears 3 days after emergence in the imago stage and reaches maximum levels by the 10th day
+Low maternal levels detected at the 4-cell stage (PubMed:18956345). At gastrulation, uniformly expressed in the animal cap and marginal zone (PubMed:18956345). During neurulation, expressed in the notochord, underlying gastrocoel roof plate and ventral epidermis (PubMed:18956345). In tailbud embryos, expression is maintained in the notochord and is also found in the anterior brain, eye and head mesenchyme and in the heart, dermomyotome, pronephros, lateral blood islands and proctodeum (PubMed:18956345). Expression persists in head tissues, heart and notochord in late tailbud stages (PubMed:18956345)
+Expressed both maternally and zygotically throughout early development (at protein level). Isoform 1 accumulates throughout oogenesis but isoform 2 is translationally masked until oocyte maturation
+Expressed throughout embryonic development, with highest levels detected in cycling cells including in mitotically active cells during germ-band extended stages, as well as proliferating cells of the CNS and endoreduplicating cells of tissues such as the midgut at later embryonic stages. Maternal mRNA detected in syncytial stage embryos and disappears by the cellular blastoderm stage. A single transcript of 1.4 kb is detected at the highest level in 4 to 8 hour embryos, and at a relatively high level in 0 to 2 hour embryos. Lower levels of the transcript are detected in unfertilized eggs, larvae, pupae and adult
+Expression increased from midgestation to the end of the pregnancy
+Expressed at every stage (PubMed:19581445). Expressed in the embryonic salivary glands, the distal part of the proventriculus and the ring gland as well as weak expression in the midgut (PubMed:19581445). At third instar larval stage, expressed at the proventricular and ring gland (PubMed:19581445). No transcript detected in the larval central brain, in the imaginal disks, the salivary glands, or in the fat body (PubMed:19581445)
+Expressed in first, second and fourth juveniles. Not expressed in eggs and adults
+Localized in the cytoplasm of early spermatogonia and spermatids of different spermatogenic stages and in the flagella of mature epididymal spermatozoa
+At 9.5 dpc, expressed solely in the ventral halves of the optic stalks and vesicles without proximo-distal restriction. Expression in the optic stalk diminishes after 11.5 dpc and becomes restricted to the inner layer of optic cup in its ventral half. Expression persists in the ventral halves of all neural retina layers (inner and outer nuclear layer) at 14.5 dpc and 16.5 dpc, and the ganglion cell layer, inner nuclear layer and photoreceptor layer in the adult
+SpoVB transcription takes place during the second hour of sporulation. It may be transcribed mainly, if not only, in the mother cell. Indeed, it is required only in the mother cell
+Expressed throughout anther development
+Expressed predominantly in the bract primordia during panicle development
+At 8 dpc highly expressed in the ventricular portion of the heart tube, with no detectable expression in the atrial or sinus venosus regions; also expressed in the proximal outflow tract of the heart tube at minimally detectable levels. At 9-10 dpc expression is well established in the proximal outflow tract region adjacent to the ventricular segment. At 11 dpc, expression becomes restricted to the ventricular region
+Expression increases during mitosis (at protein level)
+Not detected in the spinal cord at 21 dpc. Expressed weakly at postnatal day 1 (P1) and a strong expression seen at P21 and this continues into adulthood
+Expressed in cells that spans the width of the neuronal plate in the presumptive hindbrain at the end of gastrulation. Expressed in r5- and r6-derived neuronal crest cells at the 14 somite stage. Expressed in r5 and r6 until the 20 somite stage (19 hours). Expressed in Mauthner cells of the r4, in cells of the blood-forming region at the base of the yolk extension, in Rohon-Beard cells in the trunk and tail, in a bilateral patch of cells ventral to the third somite which corresponds to the position of the primordial germ cells at 20 somite stage (19 hours). Expressed in r6 at 24 hours. Expressed in r4 and r5 at 42 hours
+Expressed in the procyclic form
+First expressed the mesoderm of the emerging dorsal pancreatic bud at stage 17-18. Also expressed in the thyroid anlagen. Expression persists throughout the dorsal pancreatic mesoderm through 6 dpc as the pancreas continues to enlarge. After 6 dpc, the amount of mesoderm in the pancreas declines to a minimal level and little or no expression is seen. The expression in the mesoderm of the thyroid persists at least through 8 dpc in the development of this organ. Weakly expressed within the emerging lung buds and developing gut. Also expressed in developing carniofacial structures. At stage 17, expression is restricted to the cranial paraxial mesoderm. At stage 24, expressed in the corners of the frontonasal mass (globular processes) where the lip will fuse. At stage 26 through 29, becomes focused in the center of the frontonasal mass. At stage 30, further restricted to the future egg tooth. By stage 34, found in the egg tooth and structures derived from the frontonasal mass, such as the premaxillary mesenchyme (PubMed:26385749)
+Moderately expressed during growth. Increases during development, peaking at around 8 hours of development (mound stage) and then decreases gradually during the later stages. Mainly expressed in the prestalk cell population during the later multicellular stages. Required for prestalk specific gene expression and for prespore cell differentiation. Expressed (at protein level)
+Expressed in the G2/M phases and disappears at the metaphase of mitosis
+Induced from days 15 to 30
+Expressed during fruit development, showing a maximum at 4 to 10 days postanthesis
+Expressed in the vegetative cells. Increases during aggregation to mound stages (6-12 hours) and decreases at late developmental stages (18-24 hours)
+Not expressed in embryos. Expressed in larvae and pupae
+Highest kidney expression is found in weaning rat followed by adult. Lowest expression is found in suckling rat
+Expressed during early embryonic development. Expressed only in undifferentiated embryonal carcinoma cells
+Expressed in adult liver but not in neonatal or embryonic liver. Not detected in preadipocytes but strongly induced in mature adipocytes
+In the embryonic brain expressed in specific subtypes of neurons. Found in the tectal region, hindbrain, neurons in the nucleus of the anterior commissure, posterior commissure, postoptic commissure, medial lateral fascile and epiphysis. Localized to both central and peripheral axons of the primary sensory neurons
+In roots, expressed only in the quiescent center (QC) and the columella stem cells (CC) initials (PubMed:20798316, PubMed:23370719). Induced during lateral root formation (PubMed:23370719)
+Levels of mRNA accumulate during early fruit development
+Levels accumulate after the removal of the food source and increase with the onset of development (expression peaks at 3-4 hours of development and decreases to a low baseline level by 7 hours). Expression remain elevated during chemotaxis and formation of multicellular assemblies, and then return to baseline levels for the rest of the development
+Expressed throughout all embryonic and post-embryonic stages
+First detected at the 12-somite stage. From the 20-somite stage, expressed in the otic vesicle
+Expression peaks at embryonic stage 10A, is slightly reduced by stage 10B, and undetected in stage 11
+Accumulates gradually in the embryo during the seed development to reach high levels in mature seeds, but repressed rapidly in germinating seeds
+Accumulates at the zone of impending infection in the presence of Sinorhizobium meliloti during the preinfection period, in the epidermal cells of the differentiating root zone (PubMed:7696879, PubMed:8972593, PubMed:12059100). During nodulation, first observed in root tips prior to nodule formation (PubMed:8972593). Later, after rhizobial infection, specifically associated with the zone of nodule development, including nascent nodule primordia, at the site of sustained bacterial infection (PubMed:8972593, PubMed:12059100)
+Expressed both maternally and zygotically during embryonic, larval and pupal development
+Expression is low at postnatal day 0, increases at postnatal day 7, peaks at postnatal days 14 and 21 and decreases at 2 months of age
+Highly expressed in the pith and vascular bundle in the stem. Found in the pedicel of young buds. Also expressed in the inner epidermis of carpels and pedicels in mature flowers. In siliques, mostly expressed in inner epidermis of the valve
+Expressed in all nuclei in the early embryo until the comma stage, and then is expressed in body wall muscle cells and pharynx in the embryo (PubMed:17716643). Expressed in muscle until the late larval stages (PubMed:17716643). In larvae, highly expressed in intestinal cells, lateral hypodermal (seam) cells, Pn.p ventral hypodermal cells, and spermatheca (PubMed:17716643). In L3 stage larvae, expressed at low levels in distal tip cells during the ventral-to-dorsal second and longitudinal third migration phases, but not expressed during the first migration phase (PubMed:17716643). In L4 stage larvae, expressed at low levels in the ventral nerve cord (PubMed:17716643)
+Isoform A is expressed maternally and both isoforms are expressed zygotically from 6-9 hours embryos through to adulthood
+It is synthesized a few days immediately following germination, and again a few weeks later when the cotyledons senesce
+In the brain, expression is high at embryonic day 18 and continually decreases through to postnatal day 60
+Expression begins in the embryo, increases in neonates and decreases in the adult
+Appears on the eighteenth day of gestation in the airway epithelium
+Expressed during microsporogenesis and megasoprogenesis (PubMed:10465788). Expressed during ovule development (PubMed:25378179)
+Uniformly expressed throughout interphase of the cell cycle
+KAP6 proteins are first expressed in differentiating hair shaft keratinocytes a considerable distance above the proliferative zone of the follicle bulb
+Expressed during all phases of oocyte maturation; localized at the meiotic spindle and microtubule organizing center during meiosis
+Detected in some seeds from 3 days after pollination (dap) to 11 dap
+At 17.5 dpc, it is primarily expressed in lung, spleen, thymus, testis, placenta, small intestine and stomach
+The mRNA encoding this LD-NCAM is the major transcript present in both maternal RNA and in the embryo during early neural development
+Expressed in chemotactically competent cells but in not vegetative cells
+Expression first detected in developing brain at embryonic day 15; the level of expression increases throughout embryonic development and postnatally into adulthood
+Expressed in immature seeds at 20 days after flowering (PubMed:18980324). Expressed in radicles (PubMed:16717422)
+Expressed in germinating pollen
+Accumulates mostly in developing organs. During early stages of organ development, promotes cell proliferation, influences cell-size threshold for division and shortens the period of meristematic activity. In postmitotic cells, enhances cell expansion
+Detected at 16 and 18 days post coitum (dpc) in vertebrae osteoblasts. Detected in calvarial tissue and in the stratum spinosum and granulosum of the overlaying epidermis at 18 dpc. Detected at postnatal day 14 in osteoblasts and osteocytes of the calvarium. Detected in tibias at postnatal day 14 in osteoblasts and a lesser degree in osteocytes, however by postnatal day 84 it is detected in osteocytes in compact bone. Detected in teeth at postnatal day 14 in odontoblasts and ameloblasts. By postnatal day 84, expression can still be detected in odontoblasts however little to no expression can be detected in ameloblasts. Detected at 18 dpc at moderate levels in macrophages within the liver, with minimal expression in brown adipose tissue. Detected at 18 dpc in suprabasal layers of the skin
+Expressed specifically at aggregation-stage
+Expression varies across the cell cycle, with highest levels in G2 phase (at protein level). No statistically significant changes at the transcript level
+Maximal expression is detected at postnatal day 13 (P13) (at protein level)
+Expressed in spermatogenic cells from the spermatocyte stage to the round spermatid stage
+Expressed at all stages of development in hermaphrodites (PubMed:10656761). More abundant in embryos than in larvae and adults (PubMed:10656761). First expressed in embryos prior to morphogenesis, and after morphogenesis begins, primarily expressed in the head and tail regions (PubMed:10656761)
+Expressed in the hypodermis at the beginning of embryonic morphogenesis and throughout larval and adult stages
+First detected at 8.75 dpc, in the ventral midline of the neural tube and in the ventral medial somites. At 10.5 dpc, expression in the notochord is maintained in the caudal region. Expression is lost in the floor plate, but is retained in the ventral half of the neural tube and in the sclerotome of the adjacent somites. In the midbrain, expression confined to two lateral stripes adjacent to the floor plate. Also expressed in the gut mesenchyme along the length of the gastro-intestinal tract and in the mesenchyme of the posterior half of the limb. Expressed in the underlying mesenchyme of the epithelium of a number of tissues including lung, gut and whisker. Also expressed in the perichondrium and in the androgen-producing interstitial somatic cells of the developing testis
+Expressed during growth and early development but then decline, reaching undetectable levels after the mound stage
+First detected in whole embryos at 11 dpc, strong and increasing protein levels are observed in the brain from 14 dpc to early postnatal development. Expression continues into adulthood, though at a substantially decreased level
+Isoform a: only expressed in embryos (PubMed:9540836). Isoform b: present at all developmental stages (PubMed:9540836). Not expressed during spermatocyte meiosis (PubMed:16943775)
+Expressed throughout embryogenesis, maximally during the 5-12 hours period
+Expressed during the parasite erythrocyte stages, namely in trophozoites and schizonts
+Detected in embryos (at protein level). Detected in the yolk syncytium and in mesendodermal cells in the head and trunk region during early somitogenesis. Detected in the developing eyes, the anterior midbrain, the pineal gland and in anterior somites at 24 hpf. Detected only in the eyes and the pineal gland at 3 and 4 dpf. Detected in retinal pigment epithelium at 4 dpf
+Expressed early in embryogenis in a sickle-shaped area in the posterior zone of the blastoderm. With the beginning of gastrulation, it is found in the primitive streak primordium, then in the young and medium-sized streak, however not in the mesoderm after its emergence. In the fully-extended streak, it is restricted to its middle, i.e. the prospective ventral mesoderm. It is then undetectable by in later stages
+Expressed in the center of the leaf primordia at plastochron 1 (P1) stage. In the P2 leaf primordia, expressed in the mid-vein and the future large veins. In P3 and P4, expressed in the vascular regions and the future bundle sheath extension cells. Expression in leaf primordia quickly disappears after P4 stage. In the inflorescence meristem, expressed at the predicted site of the next bract, and then in the vascular tissue of the developing rachis-branch. In developing floral organs, expressed in the adaxial side of the palea, lemma and stamen
+Strongly expressed in the brain in early developmental stages. Expression gradually decreases during development, from very high levels at 13 dpc down to hardly detectable in the adult at day 20 postnatal and later on (at protein level)
+Expressed at high levels in the very early conceptus limited to polar trophectoderm. Strongly expressed in the ectoplacental cone shortly after implantation at 5.5 dpc, and the high expression remains restricted to the extraembryonic tissues at later stages. By 10.5 dpc expression is restricted to the labyrinthine trophoblast and the endodermal component of the visceral yolk sac. Between 12.5 and 14.4 dpc expression in placenta decreases, due to a number of expressing cells. On day 12 of gestation, the abundant expressing cells are trophoblast at the chorionic plate, and clustered type II trophoblast deeper in the labyrinth. Less expressed by terminally differentiated trophoblast. As early as 14.5 dpc, becomes confined to a monolayer of cells at the chorionic plate and to rare cells in septa that protrude into the labyrinth (at protein level)
+Blastula, early gastrula and hatched tadpoles; little or no expression in morula and late gastrula
+Detected on postnatal day 7 in cerebellum. Follows a caudorostral progression according to the myelination process. Appears to redistribute from the internode to the paranodal region during myelin compaction and maturation (PubMed:9396755). Expression reaches maximal levels between days 14 and 18 and remains at the same levels until adulthood
+Present at 14.5 dpc throughout the developing brain, with high expression in the cortical plate. During postnatal development, detected in all neurons, with an intense expression in the limbic system, with highest levels throughout layer V neurons in the cortex, the hippocampus, the pyriform cortex, the dorsomedial nucleus of the thalamus, the amygdala, and the hypothalamus. Cortical expression is strong throughout development, with no clear dorsoventral or rostrocaudal gradient, highest levels at P10 in layers II/III and V and in the subplate. Relatively strong expression in the mitral cells layer and anterior olfactory bulb, as well as in the Purkinje cell layer in the cerebellum. Expression in the limbic system postnatally corresponds to the time window of active synaptogenesis
+Expressed in eggs, larvae, and in male and female adult worms
+Expressed in the procambium during embryogenesis
+Weakly expressed in vegetative phase from day 2 or day 3. Increased expression after commitment to flowering from day 7 on
+Down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization. Abundant in fetal liver
+First observed in seed coat and the endosperm (PubMed:20035035). Displays a polar localization in the embryo protoderm (PubMed:20035035). During embryo development, expressed in the radical tip. In seedlings, localized in the cotyledons, root tip, and young leaves. As secondary root tips emerge, expressed in the pericycle during the initial cell divisions. In leaves, mostly detected in the expanding basal portion, trichomes and stomatal cells. Present in rosette leaves vascular system and epidermis (PubMed:24112720). In roots of mature plants, mainly expressed in lateral root primordia and developing lateral roots (PubMed:24112720). Accumulates in buds and open flowers, mainly in the petal epidermis and the vasculature (PubMed:20035035). In the inflorescence, found in all floral organs, predominantly in the anthers, styles, and young siliques, particularly in young seeds (PubMed:20035035). Upon anthesis and later, progressively restricted to the carpel. Also observed in phloem cells of the flower stem, and in the cortical cells and interfascicular fibers (PubMed:24112720). Accumulates during tracheary element differentiation (PubMed:28921082)
+Levels increase 3-fold during embryo development with the highest level in 17 day old embryos. Relatively low levels in larvae and adults
+Expressed in two-cell stage, early blastula, early gastrula, early neurula and early and late tail bud stages
+Expressed only in the adult. Levels are low 1 week postpartum, steadily increase 2 to 5 weeks postpartum, are highest at 7 weeks and then drop to back the levels found at 5 weeks
+Expressed during vegetative growth and early stages of development
+The level of expression is highest on immature, proliferating cells and decreases as these cells differentiate
+At 7.25 dpc strong expression is found at the base of the incipient allantois and weak expression in the mesodermal portion of the posterior amnion, and, importantly, the expression did not extend to the allantois. Expression persisted until the late bud stage (7.5 dpc), but gradually faded around the early head fold stage (7.75 dpc). At an earlier stage, only weak expression is seen throughout the epiblast in 6.0 dpc. But around 6.25-6.5 dpc (before gastrulation), marked expression is evident within the most proximal layer of the epiblast that is in intimate contact with the extraembryonic ectoderm. Expression is indeed induced by extraembryonic ectoderm through signaling molecules. During germ cell formation, is expressed in putative PGC ancestors in embryos at 6.5-7.5 dpc. In migrating PGCs, expression is continuous. After the beginning of gastrulation, the expression migrates to the posterior end of the developing primitive streak at the early/mid streak stage and became very intense in the position where PGCs (Primordial germ cells) differentiate from late streak stage onward
+During development, expression in the olfactory epithelium parallels neurogenesis, peaking shortly after birth and declining in the adult
+Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development
+All stages of heart development
+Expressed at all stages during oocyte maturation, additionally expressed in granulosa cells and cumulus oophorus cells (PubMed:19192343). Expressed primarily with other SCMC components in the subcortex of oocytes and early embryos (PubMed:25542835). Expression is excluded from cell-cell contact regions after the 2-cell stage (PubMed:25542835)
+Specifically expressed in the bloodstream form (at protein level)
+Expression in lung increases after birth
+No obvious expression before embryo hatching but is expressed at later stages (at protein level)
+Isoform A and isoform C are present mainly in embryos and pupae. By contrast, isoform D appears to be expressed most markedly in third instar larvae and pupae
+Widely expressed during embryonic development (at protein level). In pre-primitive streak stage embryos, expressed in the epiblast and in a salt-and-pepper fashion in the forming hypoblast (stages XI and XIII) (at protein level). As the primitive streak starts to form, strongly expressed in the epiblast of the streak itself (stage XIV) and in the mesoderm emerging from it, whereas expression in the lower layer tends to decrease (stages 2 through 4+). Expression in the area opaca is lost by stage 3+. At later stages, continues to be expressed in the mesoderm, but not detected in the endoderm (stages 5 through 8). At stage 5, expressed in all cells of the germinal crescent. At stage 8 and subsequently, strongly expressed in the neural plate and neural tube with particularly strong expression in the anterior hindbrain/posterior midbrain. At stage 9 and subsequently, still expressed in neural tissue and in primordial germ cells (at protein level). At stage 33, still expressed in germ cells. At stages 42-43, expressed in male and female gonads, as well as in spleen and brain, but at much lower levels than in proliferating embryonic stem cells
+In the mammary gland, expression increases dramatically during pregnancy. Levels fall during lactation and increase again during post-lactational regression of the mammary gland
+Expressed in pollen and pollen tubes, as well as in seed coats. Specific increase of expression in innermost layer cells of the mesocarp (cells located between the outer epidermis (exocarp) and the inner epidermis (endocarp) of the carpel) during carpel maturation (at protein level). Present in suspensor of embryos and in embryos root tips. Absent in very young organs, but levels increase as they mature
+Expressed at high levels at the middle of the calcification stage of shell formation. Expression levels are similar at 3-4 hours post-oviposition prior to entry of the egg into the uterus and at 16-17 hours post-oviposition during eggshell calcification. Expressed in tibia from 5 dpc and in mandible from 7 dpc until the end of embryonic development at 19 dpc. Expression detected first in osteoblasts, in later stages both in osteoblasts and osteocytes, and by the end of embryonic development mainly in osteocytes
+Expressed in young flower buds and decreases just before the petals appearance
+Produced at stage IV of sporulation in forespore and spore integuments
+Accumulates progressively in fiber during their elongation and reach highest levels at 15 days post-anthesis (DPA)
+Detected in stage 9 buds and appears to be confined to microspores
+Expressed in the branchial arches, optic vesicle and mesonephric tubules of the kidney at 10.5 dpc (PubMed:17920587). Expressed in the internal endodermal layer and in the nascent bronchial tips of the lung at 11.5 dpc (PubMed:17920587)
+Ubiquitous in embryos at the early somite stage
+Expressed in adults but not in embryos
+After fruiting bodies have been formed and during germination
+Expressed throughout development, at highest level in the L1 stage and lowest in L3. Peripheral staining pattern in early embryos. The staining in 1-cell embryos is weak and uniform just after the completion of meiosis, but increases in intensity and becomes concentrated at the anterior periphery during pronuclear migration. The peripheral staining becomes restricted to about 50% embryo length during the pronuclear meeting and pronuclear fusion stage. By early anaphase, the staining extends posteriorly beyond the midline of the zygote and covers about 60% of the total length of embryos. In 2- and 4-cell stages, staining is uniform at the periphery of the AB cell, its daughters and the EMS cell, but peripheral staining in P1 and P2 is restricted to the boundaries with other blastomeres
+Expressed only late in the growth cycle
+Expression is activated at, or just after the midblastula stage, about 2 hours before the appearance of the embryonic shield. In early gastrulation, expression marks the anterior shield and by late gastrulation, expression is restricted to the rostral crescent and medial strip. Levels of GSC then decline and disappear at 12 hours post-fertilization
+Expressed by cells, when grown on bacterial lawns, or by cells cultured under conditions that give rise to fusion-competent gametes, i.e. in a suspension of bacteria in the dark for 15 hour at 21 degrees Celsius. Does not appear to be expressed by axenically grown vegetative cells or by cells during the asexual, developmental life-cycle induced by removing axenic cells from HL-5 media. In contrast, ponticulin is expressed by vegetative cells and during the early stages of the asexual developmental cycle
+Induced during germination in embryonic tissues, and strongly expressed in certain parts of young seedlings, in the tips of cotyledons and to a certain degree in developing leaves and roots
+Expressed in sciatic nerve and placenta at 15.5 dpc
+Expressed in pharyngeal cells throughout development, vulval precursor cells during the larval L3 stage, and the seam cells and hypodermal syncytia derived from the seam cell lineages throughout the larval L4 stage and adulthood
+During utricle development, it is first expressed at 15 dpc and 16 dpc and peaks at 17 dpc. It drops at 18 dpc but increases again at 19 dpc, possibly corresponding to a second wave of hair cells that are generated at 15 dpc
+Detected at low levels in newborns. Levels increase strongly and are highest in hippocampus from 7 day olds. Detected at low levels in hippocampus and olfactory bulb of 3 month olds (at protein level)
+Expressed during embryogenesis (at protein level). Expressed in larvae and pupae
+First expressed in primordial germ cells between the comma to 2-fold stage of embryogenesis
+Expressed in the pericardium of the developing embryo and in the epidermal layer surrounding the digits
+Increased expression at later stages of flower development
+Adult and larval stages
+Expressed both maternally and zygotically in adult females. Levels of the long isoform remain fairly constant from ovaries to embryos, the levels of short isoform decrease dramatically
+Expressed at low levels on peripheral T-cells and is strongly up-regulated after activation, peaking 6 to 9 days after the activating stimulus
+Not detected in microspores before and at stage of pollen mitosis I. Expressed in bicellular, tricellular and mature pollen grains
+Ubiquitously expressed in neurogenic regions of the embryonic brain
+In the developing brain, expressed as early as embryonic day 10-13, and transiently up-regulated during the late embryonic and neonatal periods. Cerebellin and [des-Ser1]-cerebellin are expressed as easly as postnatal day 3-4. The levels of both peptides rise rapidly to a maximum at approximately day 25-30 after birth, whereafter they fall to stable adult values
+Present transiently in visceral arch 3. Also expressed in the forebrain, rhombomeres R3 and R5 of the hindbrain and in the pronephros
+At 9.5 dpc, expressed in the otic vesicle, also known as the otocyst (at protein level) (PubMed:33795231). Between 10.5-12.0 dpc, expressed in various regions of the developing ear, including the developing vestibular system and the epithelium of the cochlear duct (at protein level) (PubMed:33795231). Expressed in the blastocyst at 3.5 dpc (PubMed:8853987). At 7.5 dpc, expressed in the extraembryonic endoderm and in the mesoderm of the chorion and amnion (PubMed:8853987). At 9.5 dpc, in the facial region, forelimb, pharyngeal epithelium, mesenchyme of the pharyngeal arches and the lateral body wall and, at 12.5 dpc, in the trigeminal ganglia, developing central nervous system and in the mammary buds (PubMed:8853987). Expressed in a continuous stripe of mesenchyme in the ventro-lateral body wall between the fore and hind limb buds at day 10.5-11.5 dpc (PubMed:16222716). Also expressed in the epithelium of the first and third mammary placodes at 10.5 dpc, and in all five pairs of mammary placodes between 11.5 and 13.5 dpc (PubMed:16222716)
+Weakly expressed in G1 phase, and highly expressed during S phase
+Earliest and highest expression at 11 dpc. Expression is detected in developing somits, brain, neural tube, and pericardiac mesenchyme. By in situ hybridization is detected in marginal zones bordering the mitotically active periventricular region, weakly extending to the ventral aspect impinging on motor neuron columns. Also detected in the ventral third of the developing neural tube, and in spinal cord throughout the full length of the neural tube. Also detected at 17.5 dpc in lung mesenchyme. Expressed at 11.5 dpc in spinal cord, predominantly localized to postcrossing commissural axons
+Expression is highest in whole embryos at 11 dpc and gradually decreases as embryonic development progresses. At 7.5 dpc, expressed in germ cell layers. At 14.5 dpc, expressed at highest levels in thymus, liver, gastrointestinal tract, lung and the rapidly proliferating ventricular zone of the brain
+Expressed both maternally and zygotically. Zygotic expression peaks at 12-18 hours of embryonic development
+Strongly expressed in apical regions of the assembling ommatidia of the eye-imaginal disk. Apical expression requires the receptor tyrosine kinases Egfr and sev/sevenless
+Expressed in the embryo and larva throughout development, with highest levels in the developing brain, eyes and at the boundaries between somites
+First detected 14 day old testes, with the first appearance of stage IX pachytene spermatocytes. Highly expressed in stage X and XI pachytene and diplotene spermatocytes from day 18 to 22
+Expressed from the 34 somite stage
+Adult expression levels are reached by day 25 after birth
+Expressed throughout the embryo at stage 11 with a higher level in the anterior region. At stage 12, a few cells show expression
+Expression is present at low levels as early as 9 dpc and 10 dpc, but strongly increases at 13 dpc and remains at high levels up to 15 dpc. Also expressed in adult
+In embryonic cerebral cortex is first weakly detected at 12.5 dpc, and thereafter gradually increased. At 13.5 dpc expression is observed mostly in the preplate
+First expressed at day 7.5, exclusively in the allantois where expression continues through day 8.5. At day 9.5, expression is found in the genital papilla, body wall and limb buds (higher levels in hindlimb). At day 12.5, expressed in the mesenchyme of the mandibular arch, of the lung and of that surrounding the trachea. Also found in the sinus venosus/common atrium of the developing heart
+Expression decreases during senescence of embryonic fibroblasts (HEFs). Expression peaks at the G1/S phase boundary
+Expressed as early as 7.6 dpc. Expression remains high through 15.5 dpc (PubMed:10854042). In 3T3-L1 cells, expression is transiently induced during late adipocyte differentiation (PubMed:24061474)
+Expressed in the apical meristem, root vasculature and all veins in the cotyledons of young developing seedlings (PubMed:16461385). Loss of expression in the older maturing tissues (PubMed:16461385). Accumulates transiently in developing seeds (e.g. including embryos and seed coat), reaching a peak ten days after pollination (10 DAP) (PubMed:32354877)
+Expressed during S phase, in a cell-cycle-dependent fashion. Expression levels are highest in embryos (0-4 hours old) and in the ovaries of adult females. Little to no expression in larvae and pupae (at protein level)
+Expressed in developing parvalbumin-positive basket cells
+Expressed throughout development, but at a very low level during the fruiting stage
+Detected in larvae and adults
+Ubiquitously expressed in early mouse embryos (PubMed:10727859). Detectable in brain from postnatal week 1, in testis from postnatal week 3
+Exists in integuments throughout the larval stages and disappears at larval-pupal ecdysis. Present in lower amount adult cuticle after eclosion
+Expressed at steady levels during development and aging
+Expressed maternally and zygotically. Maternal expression declines during cleavage stages and gastrulation. Expression then increases during neurula and tailbud stages
+Highly expressed in ventral cells of the neural tube and within axons of the peripheral nervous system during development. Expressed in the vestibulo-acoustic system and hindbrain as early as 11.5 dpc. Detected in the spinal cord at 12 dpc. Expressed in cells of the developing outer retina. Also expressed in mesenchyme adjacent to vessels. In myogenic progenitor cells, highly expressed during early development (11.5 dpc) and progressively repressed as developments proceeds (PubMed:27446912)
+Expressed in the 3-fold stage embryo
+Expressed at the outer limiting membrane of the retina at 18.5 dpc
+Expressed zygotically from late gastrula stages, persisting throughout embryogenesis with highest expression between stages 30 and 35
+Specifically expressed during meiotic prophase. Transiently increases in female gonads from 13.5 dpc to 16.5 dpc, the time during which meiosis proceeds from pre-meiotic replication to pachytene stages. Its expression is barely detectable in fetal male gonads. In adults, it is expressed in testis, but not in any other tissue tested. Abundance increases from 10 d post partum (dpp) to 18 dpp, during which time the first wave of spermatogenesis proceeds synchronously from pre-leptotene to pachytene stages
+In developing ovule, expressed in all cells of the young nucellus, including the functional megaspore. After the initiation of megagametogenesis, expressed in most cells of the ovule, including the integuments, the developing megagametophyte, and the funiculus. In mature ovules, strongly expressed in the cellularized megagametophyte. After double fertilization, expressed in the developing embryo and the free nuclear endosperm until seed maturity. Expressed in developing male gametophytes and mature pollen grains
+Expressed from the end of pachytene until the completion of meiosis I
+Highly expressed during embryogenesis, lower expression in larvae, pupae and adults
+Accumulates progressively in flower limbs during flower development, reaching maximal levels at anthesis
+Low level expression in the developing fetus, increased in the neonate, and maximal in the adult
+In the salivary glands of mid instar larvae levels dramatically increase during puff stage 1 at 98-106 hours of development. Levels remain constant and abundant in late larvae until puff stage 10, then decrease by stage 11