['Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant accumulation of low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in the vessel walls. Previous studies clearly demonstrated an association specifically between the oxidized type of LDL (oxLDL) and atherosclerotic lesion formation. Further observations revealed that these atherosclerotic lesions displayed enlarged, lipid-loaded lysosomes. By increasing natural antibodies against oxLDL, pneumococcal vaccination has been shown to reduce atherosclerosis in LDL receptor knockout (Ldlr', 'By transplanting NPC1 bone marrow into lethally irradiated Ldlr', 'While there were no differences in plaque morphology, a reduction in plaque size and plaque inflammation was found in immunized NPC1'] Does prevention of oxLDL uptake lead to decreased atherosclerosis in hematopoietic NPC1-deficient?