['To evaluate the role of water channel AQP4 in NMDA-induced brain injury in mice.', 'In AQP4 gene knockout (AQP4(-/-)) mice, brain injury was induced by microinjection of NMDA into the cortex. The injured area was determined by toluidine blue staining, degenerated neurons were detected by Fluro-Jade B staining, and increased blood-brain barrier (BBB) permeability was evaluated by IgG immunostaining.', 'Compared with wild-type mice, AQP4(-/-) mice exhibited increased cortical lesion area, aggravated neuron degeneration, and increased BBB disruption after NMDA microinjection.'] Does [ Deficiency of water channel AQP4 aggravate NMDA-induced brain injury in mice ]?