['Donation after circulatory death (DCD) is current clinical practice to increase the donor pool. Deleterious effects on renal graft function are described for hypothermic preservation. Therefore, current research focuses on investigating alternative preservation techniques such as normothermic perfusion.', 'We compared continuous pressure-controlled normothermic ex vivo kidney perfusion (NEVKP) with static cold storage (SCS) in a porcine model of DCD autotransplantation. After 30 minutes of warm ischemia, right kidneys were removed from 30kg Yorkshire pigs and preserved with 8h NEVKP or in 4°C histidine-tryptophan-ketoglutarate solution (SCS), followed by kidney autotransplantation.', 'Throughout NEVKP, electrolytes and pH values were maintained. Intrarenal resistance decreased over the course of perfusion (0h 1.6±0.51 mmHg/mL/min vs. 7h 0.34±0.05 mmHg/mL/min, p=0.005). Perfusate lactate concentration also decreased (0h 10.5±0.8mmol/L vs. 7h 1.4±0.3mmol/L, p=0.0001). Cellular injury markers LDH and AST were persistently low (LDH<100U/L, below analyzer range; AST 0h 15.6±9.3U/L vs. 7h 24.8±14.6U/L, p=0.298). Following autotransplantation, renal grafts preserved with NEVKP demonstrated lower serum creatinine on day 1-7 (p<0.05) and lower peak values (NEVKP 5.5±1.7mg/dL vs. SCS 11.1±2.1mg/dL, p=0.002). The creatinine clearance on day 4 was increased in NEVKP preserved kidneys (NEVKP 39±6.4mL/min vs. SCS 18±10.6mL/min, p=0.012). Serum NGAL at day 3 was lower in the NEVKP group (1267±372 vs. 2697±1145ng/mL, p=0.029).'] Does continuous Normothermic Ex Vivo Kidney Perfusion improve Graft Function in Donation after Circulatory Death Pig Kidney Transplantation?