Australian box jellyfish is one of the most toxic animals in the world. After stinging, its toxin can cause skin necrosis and severe pain, and also invade the heart of the person, causing the person to die due to cardiac arrest in a short time. The venom carried in a box jellyfish is enough to kill 60 people. There is currently no special drug for its venom. Recently, researchers have discovered through a genome-wide screening method that a protein called ATP2B1 in human cells is a necessary condition for the toxicity of box jellyfish venom. The researchers believe that lowering cholesterol through targeted therapy can fight the box Venom shaped jellyfish. Which of the following can be the premise of the above argument? ['Targeted therapy is a safe and reliable method.', 'ATP2B1 protein requires cholesterol.', 'No side effects on the human body after lowering cholesterol.', 'Targeted therapies for cholesterol reduction have been developed.']