['Previous reports have identified interleukin-2 (IL-2), quantified in the supernatants of QuantiFERON', 'A multicentre study of 161 consecutive adult patients undergoing evaluation for active TB at eight TB Units in Spain. Interferon-γ (IFN-γ) and IL-2 were assessed in the supernatant of QFT after 16-24\xa0h and 72\xa0h of incubation. The accuracy of IL-2 for indicating latent TB infection (LTBI) was assessed by receiving operating characteristic curves. .', 'Twenty-eight participants were not infected, 43 had LTBI, 69 had TB, and 21 were not classifiable. Median (interquartile range) IL-2 concentrations after 72\xa0h of incubation were 0.0\xa0pg/mL (0.0-0.0) in uninfected individuals, 261.0\xa0pg/mL (81.0-853.0) in LTBI individuals, 166.5\xa0pg/mL (33.5-551.5) in patients with extrapulmonary TB, 95.0\xa0pg/mL (26.0-283.0) in patients with smear-negative pulmonary TB, and 38.5\xa0pg/mL (7.5-178.0) in patients with smear-positive pulmonary TB (p <0.0001). The area under the curve of the receiving operating characteristic curve (95% CI) of IL-2 after 72\xa0h of incubation for the diagnosis of LTBI was 0.63 (0.53-0.74) when all TB cases were considered as a single group, ranging from 0.59 (0.47-0.71) to 0.72 (0.58-0.85) when only extrapulmonary and smear-positive pulmonary TB cases respectively were considered.'] Is detection of interleukin-2 useful for distinguishing between latent and active tuberculosis in clinical practice : a prospective cohort study?