SafeZone mosquito repellant has been shown in laboratory settings to be effective for twelve hours against the female anopheles mosquito, the only mosquito that transmits malaria. SafeZone, however, is not effective against mosquitoes that do not transmit malaria. The only instance in which SafeZone does not repel the female anopheles mosquito is when this mosquito can detect any ruptured blood vessels, a state that inevitably results whenever any kind of mosquito bites a person. Ttherefore, assuming one does not have any ruptured blood vessels on their skin before applying SafeZone, that person will not be able to catch malaria for up to twelve hours. Which of the following, if true, would argue most against the use of SafeZone in areas in which malaria is endemic? ['SafeZone mosquito repellant has been shown to cause irritation that may result in a mild rash.', 'The male Anopheles mosquito also feeds on humans and is active at the same time as the female.', 'Once a person has contracted malaria, he or she may experience ruptured blood vessels in the form of bleeding gums and a bloody nose.', 'The culex mosquito, a different species of mosquito, is found in some areas in which the anopheles mosquito is found.']