['We correlated oxygen, flow, and pressure indices of cerebrovascular reactivity (CR) with extracellular cerebral metabolite concentrations in a porcine model of intracerebral hemorrhage (ICH).', 'Continuous advanced multimodal monitoring including microdialysis, cerebral blood flow and P(br)O(2) probes were placed 1 cm in front of the coronal suture in the grey/white matter junction. Following a period of 1 h of monitoring, an autologous arterial ICH with defined volumes (3 mL) was induced. Pressure-, oxygen-, and flow-related autoregulation indices (PRx, ORx, and FRx) were simultaneously calculated and correlated hourly with extracellular cerebral metabolites, including glucose, lactate, pyruvate, and glutamate.', 'Seventeen swine were monitored on average 12 continuous hours per animal. FRx correlated highly with ORx (0.96, P = <0.001), but values of both FRx and ORx > 0.2 did not correlate with any microdialysis metabolite. Values of PRx > 0.2 correlated highly (0.65, P < 0.001) with the lactate/pyruvate ratio, values of PRx > 0.3 correlated with glutamate (0.67, P < 0.05), the lactate/pyruvate ratio (0.60, P < 0.01), and P(br)O(2) (-0.65, P < 0.01).'] Does pressure reactivity index correlate with metabolic dysfunction in a porcine model of intracerebral hemorrhage?