['To evaluate the effect of Pringle maneuver time on tumor recurrence following liver resection in patients with hepatocellular carcinoma (HCC).', 'In this single-center study, we retrospectively evaluated the effect of Pringle maneuver time on HCC recurrence over a 10-year period from 1999 to 2008 using a Cox regression analysis.', 'This study enrolled a total of 2,368 patients. A Pringle maneuver time of 15\u2009min was associated with HCC recurrence (log likelihood ratio test, P\u2009=\u20090.001). A Pringle maneuver time less than 15\u2009min was not a significant risk factor for HCC recurrence (hazard ratio, HR\u2009=\u20090.97, P\u2009=\u20090.708). However, a Pringle maneuver time greater than 15\u2009min was an independent predictor of HCC recurrence (HR\u2009=\u20091.41, P\u2009<\u20090.001). The patients who underwent the Pringle maneuver for over 15\u2009min had lower overall survival (OS) and recurrence-free survival (RFS) than did those who either did not undergo the maneuver or underwent the maneuver for less than 15\u2009min (both P\u2009<\u20090.001).'] Is longer duration of the Pringle maneuver associated with hepatocellular carcinoma recurrence following curative resection?