['MicroRNAs regulate gene expression at the post-transcriptional level and play important roles in cancer development, progression, and metastasis. The aim of this study was to investigate the expression of miR-92a in colorectal cancer and the normal adjacent mucosa and its potential relevance to clinicopathological characteristics and patient survival.', 'Surgical specimens of cancer tissue and adjacent normal mucosa were obtained from 82 patients with colorectal carcinomas. The relative expression levels of miR-92a mRNA in the cancer and the normal adjacent mucosa were measured by quantitative real-time reverse transcriptase polymerase chain reaction. We analyzed their correlation with tumor metastasis, clinicopathologic parameters, and clinical outcome.', 'The relative expression levels of miR-92a were significantly higher in colorectal cancer tissues than in the normal adjacent mucosa (p\u2009<\u20090.001), and a high expression of miR-92a correlated with advanced clinical stage (p\u2009=\u20090.025), lymph node metastases (p\u2009=\u20090.015), and distant metastases (p\u2009=\u20090.046). Kaplan-Meier analysis indicated that patients with high miR-92a expression had a poor overall survival (p\u2009=\u20090.001). Moreover, multivariate analysis showed that increased expression of miR-92a was an independent predictor of overall survival.'] Does overexpression of miR-92a correlate with tumor metastasis and poor prognosis in patients with colorectal cancer?