['Demineralized collagen fibers at the hybrid layer are susceptible to degradation. Remineralization may aid to improve bond longevity.', 'The aim of the present study was to infiltrate zinc and calcium-loaded polymeric nanoparticles into demineralized dentin to facilitate hybrid layer remineralization.', "Zinc or calcium-loaded polymeric nanoparticles were infiltrated into etched dentin, and Single Bond Adhesive was applied. Bond strength was tested after 24\xa0h and 6\xa0months storage. Nanomechanical properties, dye-assisted confocal laser microscopy, and Masson's trichrome staining evaluation were performed to assess for the hybrid layer morphology, permeability, and remineralization ability after 24\xa0h and 3\xa0months. Data were analyzed by ANOVA and Student-Newman-Keuls multiple comparisons tests (p\xa0<\xa00.05).", "Immediate bond strength was not affected by nanoparticles infiltration (25 to 30\xa0MPa), while after 6\xa0months, bond strengths were maintained (22 to 24\xa0MPa). After 3\xa0months, permeability occurred only in specimens in which nanoparticles were not infiltrated. Dentin remineralization, at the bottom of the hybrid layer, was observed in all groups. After microscopy analysis, zinc-loaded nanoparticles were shown to facilitate calcium deposition throughout the entire hybrid layer. Young's modulus at the hybrid layer increased from 2.09 to 3.25\xa0GPa after 3\xa0months, in specimens with zinc nanoparticles; meanwhile, these values were reduced from 1.66 to 0.49\xa0GPa, in the control group."] Do zinc-modified nanopolymers improve the quality of resin-dentin bonded interfaces?