['Allergic rhinitis (AR) is caused by an IgE-mediated inflammatory reaction consequent to the exposure to causal allergen. Resveratrol is a natural non-flavonoid polyphenol, exerting anti-inflammatory activity; β-glucan is a polysaccharide with immuno-modulatory properties. Thus, this study aimed to investigate whether these combined compounds are able of relieving nasal symptoms in children with AR due to pollen allergy.', 'The present study was conducted as placebo-controlled, double-blinded, and randomized. Globally, 68 children (36 males; mean age 7.9 years) were treated with resveratrol plus β-glucan or placebo (the diluent of active drug) two sprays (100\u2009µL/spray) in each nostril three times/day for 2 months. Nasal symptoms, including itching, sneezing, rhinorrhea, and obstruction, were assessed at baseline and after treatment. Use of rescue medication, such as cetirizine syrup, was also evaluated.', 'ClinicalTrials.gov ID NCT02130440.', 'Children treated with active drug achieved a significant reduction in all nasal symptoms: itching (p\u2009=\u20090.0001), sneezing (p\u2009=\u20090.0009), rhinorrhea (p\u2009=\u20090.009), and obstruction (0.002) as well as antihistamine use (p\u2009=\u20090.003). Placebo did not affect nasal complaints and cetirizine use. The intergroup analysis showed that active treatment was significantly superior to placebo about reduction of AR symptoms and rescue medication use.'] Does resveratrol plus carboxymethyl-β-glucan reduce nasal symptoms in children with pollen-induced allergic rhinitis?