['Activation of the mTOR pathway has been observed in thyroid cancer, but the biologic consequences regarding tumor behavior and patient prognosis remain poorly explored.', 'We aimed to evaluate the associations of the mTOR pathway with clinicopathologic and molecular features and prognosis through the immunocharacterization of pmTOR and pS6 expression (as readouts of the pathway) in a series of 191 papillary thyroid carcinomas.', 'pmTOR expression was associated with distant metastases (P\xa0=\xa0.05) and persistence of disease (P\xa0=\xa0.05). Cases with greater expression of pmTOR were submitted to more '] Is pmTOR a marker of aggressiveness in papillary thyroid carcinomas?