["A single injection of the cyclooxygenase-2 (COX-2) selective inhibitor NS-398 reduces bone's osteogenic response to a single period of mechanical loading in female rats, while women taking COX-2 selective inhibitors do not have lower bone mass. We show that daily NS-398 injection does not influence bone gain from repeated loading in female mice.", "Prostaglandins are mediators of bone cells' early response to mechanical stimulation. COX-2 expression is up-regulated by exposure of these cells to mechanical strain or fluid flow, and the osteogenic response to a single loading period is reduced by COX-2 inhibition. This study determined, in female mice in vivo, the effect of longer term COX-2 inhibition on adaptive (re)modelling of cortical and trabecular bone in response to repeated loading.", 'Nineteen-week-old female C57BL/6 mice were injected with vehicle or NS-398 (5\xa0mg/kg/day) 5\xa0days a week for 2\xa0weeks. On three alternate days each week, the right tibiae/fibulae were axially loaded [40\xa0cycles (7\xa0min)/day] three hours after injection. Left limbs acted as internal controls. Changes in three-dimensional bone architecture were analysed by high-resolution micro-computed tomography.', 'In control limbs NS-398 was associated with reduced trabecular number but had no influence on cortical bone. In loaded limbs trabecular thickness and cortical periosteally enclosed volume increased. NS-398 showed no effect on this response.'] Does the cyclooxygenase-2 selective inhibitor NS-398 influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice?