['We sought to investigate if the chloride content of fluids used in resuscitation was associated with short- and long-term outcomes.', 'We identified patients who received large-volume fluid resuscitation, defined as greater than 60\u2009mL/kg over a 24-hour period. Chloride load was determined for each patient based on the chloride ion concentration of the fluids they received during large-volume fluid resuscitation multiplied by the volume of fluids. We compared the development of hyperchloremic acidosis, acute kidney injury, and survival among those with higher and lower chloride loads.', 'University Medical Center.', 'Patients admitted to ICUs from 2000 to 2008.', 'None.', 'Among 4,710 patients receiving large-volume fluid resuscitation, hyperchloremic acidosis was documented in 523 (11%). Crude rates of hyperchloremic acidosis, acute kidney injury, and hospital mortality all increased significantly as chloride load increased (p < 0.001). However, chloride load was no longer associated with hyperchloremic acidosis or acute kidney injury after controlling for total fluids, age, and baseline severity. Conversely, each 100 mEq increase in chloride load was associated with a 5.5% increase in the hazard of death even after controlling for total fluid volume, age, and severity (p = 0.0015) over 1 year.'] Does chloride Content of Fluids Used for Large-Volume Resuscitation be Associated With Reduced Survival?