['To confirm the clinical diagnosis of complete androgen insensitivity syndrome (CAIS) by molecular genetic testing in a large family.', 'PCR was performed to amplify the coding region of androgen gene, followed by direct sequencing in the patients with CAIS and relatives in this family.', 'A missense mutation Arg773His was identified in the patients (homozygous) and carriers (heterozygous).'] Does [ Replacement of androgen receptor gene cause complete androgen insensitivity in a large family ]?