[' Electrical neurostimulation has traditionally been limited to the use of charge-balanced waveforms. Charge-imbalanced and monophasic waveforms are not used to deliver clinical therapy, because it is believed that these stimulation paradigms may generate noxious electrochemical species that cause tissue damage.', ' In this study, we investigated the dissolution of platinum as one of such irreversible reactions over a range of charge densities up to 160 μC cm', ' We observed that platinum dissolution decreased during charge-imbalanced and monophasic stimulation when compared to charge-balanced waveforms.'] Does electrical neurostimulation with imbalanced waveform mitigate dissolution of platinum electrodes?