['We determined detailed time-course changes in the irisin response to acute exercise using different exercise modes.', 'In experiment 1, seven healthy males rested for 12h (8:00-20:00) to determine the diurnal variation in plasma irisin concentration. In experiment 2, 10 healthy males conducted three exercises to clarify time-course changes in plasma irisin concentration over 6h, using a randomized crossover design. The resistance exercise (R) trial consisted of eight exercises of 12 repetitions with 3-4 sets at 65% of one repetition maximum (1RM). The endurance exercise (E) trial consisted of 60 min of pedaling at 65% of maximal oxygen uptake (VO2max). In the combined mode (R+E) trial, 30 min of endurance exercise was preceded by 30 min of resistance exercise.', 'In experiment 1, no significant changes in plasma irisin concentration were observed over 12h. In experiment 2, the R trial showed a marked increase in plasma irisin concentration 1h after exercise (P<0.05), but not in the E or R+E trials. The area under the curve (AUC) for irisin concentrations for 6h after exercise was significantly higher in the R trial than in the R+E trial (P<0.05). The AUC for irisin concentrations was significantly correlated with AUC values for blood glucose, lactate, and serum glycerol (r=0.37, 0.45, 0.45, respectively. P<0.05).'] Does resistance exercise induce a greater irisin response than endurance exercise?