['To evaluate visual performance after unilateral photorefractive keratectomy (PRK) performed for >/=2.75-diopter (D) myopic anisometropia.', 'Prospective observational case series.', 'Eleven patients exhibiting >/=2.75-D myopic anisometropia appropriate for PRK.', 'Photorefractive keratectomy was performed on 11 eyes of 11 patients for myopic anisometropia ranging from -2.75 to -9.00 D. Best spectacle-corrected visual acuity (VA), contrast sensitivity (CS), and pattern visual evoked potentials (pVEPs) were measured preoperatively and at 3 and 6 months.', 'Best spectacle-corrected VA; pVEPs; and CS, measured as the area under the CS curve.', 'Best spectacle-corrected VA increased nonsignificantly 6 months after PRK. A tendency towards decreased latency time of pVEPs for both eyes was observed after PRK. A significant increase in CS occurred after PRK in the operated eye at 6 months, but a tendency toward decreased CS appeared in the unoperated eye at 3 months. Preoperative CS levels, however, were reached at 6 months.'] Does unilateral photorefractive keratectomy for myopic anisometropia improve contrast sensitivity?