['Compared to the widely adopted 2-4\xa0months of pre-operative therapy for patients with borderline resectable (BR) or locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC), our institution tends to administer a longer duration before considering surgical resection. Using this unique approach, the aim of this study was to determine pre-operative variables associated with survival.', 'Records from patients with BR/LA PDAC who underwent attempt at surgical resection from 1992-2014 were reviewed.', 'After a median duration of 6\xa0months of pre-operative treatment, 109 patients with BR/LA PDAC (BR 63, LA 46) were explored; 93 (85.3\xa0%) underwent pancreatectomy. Those who received at least 6\xa0months of pre-operative treatment had longer median overall survival (OS) than those who received less (52.8 vs. 32.1\xa0months, P\u2009=\u20090.044). On multivariate analysis, pre-operative treatment duration was the strongest predictor of survival (hazard ratio (HR) 4.79, P\u2009=\u20090.043). However, OS was similar in those whose CA19-9 normalized regardless of whether they received more or less than 6\xa0months of chemotherapy (71.4 vs. 101.8\xa0months, P\u2009=\u20090.930).'] Does cA19-9 Normalization During Pre-operative Treatment predict Longer Survival for Patients with Locally Progressed Pancreatic Cancer?