['Circulating acyl-carnitines (acyl-CNTs) are associated with insulin resistance (IR) and type 2 diabetes (T2D) in both rodents and humans. However, the mechanisms whereby circulating acyl-CNTs are increased in these conditions and their role in whole-body metabolism remains unknown. The purpose of this study was to determine if, in humans, blood cells contribute in production of circulating acyl-CNTs and associate with whole-body fat metabolism.', 'Eight non-diabetic healthy women (age: 47\xa0±\xa019\xa0y; BMI: 26\xa0±\xa01\xa0kg·m'] Does palmitoyl-carnitine production by blood cells associate with the concentration of circulating acyl-carnitines in healthy overweight women?