['Dermicol-P35 27G, an advanced collagen dermal filler, is effective for nasolabial fold (NLF) correction.', 'To compare the efficacy and tolerance of Dermicol-P35 27G premixed with lidocaine with that of Dermicol-P35 27G injected after topical anesthesia for NLF correction.', 'In a split-face protocol, 10 patients were injected with Dermicol-P35 27G/topical anest:esia or Dermicol-P35 27G/0.3% lidocaine. Patients were monitored for adverse events and for pain using the Thermometer Pain Scale (TPS) and a visual analog scale (VAS). Efficacy was measured using the Modified Fitzpatrick Wrinkle Scale and the Global Aesthetic Improvement Scale.', 'Patients experienced significantly less pain with Dermicol-P35 27G/0.3% lidocaine than with Dermicol-P35 27G/topical anesthesia (mean clinician-assessed TPS scores +/- standard deviation: 2.0 +/- 0.8 and 5.2 +/- 2.1, respectively, p<.001). Patients reported less discomfort with Dermicol-P35 27G/0.3% lidocaine than with Dermicol-P35 27G/topical anesthesia (mean VAS scores: 2.0 +/- 1.0 and 6.3 +/- 2.0, respectively, p<.001; TPS scores: 2.3 +/- 0.6 and 5.4 +/- 1.2, respectively, p<.001). Both treatments yielded similar efficacy scores and were well tolerated. Adverse events were mild.'] Does efficacy and tolerability of admixing 0.3 % lidocaine with Dermicol-P35 27G for the treatment of nasolabial fold?