['Decreased muscle mass or sarcopenia has been associated with nonalcoholic fatty liver disease (NAFLD). However, the functional consequences of this association and its pathogenesis remain ill-defined.', 'To evaluate muscle mass and function in a diet-induced NAFLD mouse model and explore its association with changes in serum insulin-like growth factor-1 (IGF-1).', 'Weight gain, visceral fat, serum biochemical parameters, liver histology, and hepatic triglyceride content (HTC) were assessed in C57/Bl6 mice fed a westernized diet during 16\xa0weeks. In addition, we determined muscle fiber size and strength of limb skeletal muscle, myosin heavy chain (MHC) protein levels, and IGF-1 serum levels.', 'Westernized diet feeding was associated with weight gain, increased visceral fat mass (epididymal pad weight: 0.76\xa0g\xa0±\xa00.13 vs. 0.33\xa0±\xa00.27\xa0g; p\xa0=\xa00.0023), hepatic steatosis (HTC: 118.2\xa0±\xa06.88\xa0mg/g liver vs. 43.26\xa0±\xa05.63\xa0mg/g<, p\xa0<\xa00.05), and necroinflammation (histological scores: 1.29\xa0±\xa00.42 vs. 4.00\xa0±\xa00.53<, p\xa0<\xa00.05). Also, mice fed the experimental diet had an increased proportion of low-diameter muscle fibers (0-30\xa0μm) and a decreased proportion of high-diameter muscle fibers (60-90\xa0μm), which correlated with decreased MHC protein levels, consistent with significant muscle atrophy. Functional studies showed that mice fed a westernized diet had reduced muscle strength and lower serum levels of IGF-1 (284.2\xa0±\xa020.04\xa0pg/ml) compared with chow-fed mice (366.0\xa0±\xa012.42\xa0pg/ml, p\xa0<\xa00.05).'] Does diet-Induced Nonalcoholic Fatty Liver Disease be Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1?