['Dry eye is a medical problem of epidemic proportions, especially among the elderly in developed countries. The treatment of dry eye is still largely inadequate because there is no way of permanently restoring normal tear function and secretion at present. At present, virtually all therapeutic regimens include tear supplements; however, their main drawbacks are the need for frequent instillation, inadequate ocular surface protection and limited mode of action, focusing on rewetting only.', 'A new gellable lubricant eye drop (Systane lubricant eye drops, Alcon) has been designed using the novel concept of a pH-sensitive hydroxypropyl-guar component that prevents surface desiccation, reduces friction and acts as a mucomimetic. The purpose of this review is to consider this topical therapy and its properties.', 'Currently published data on Systane is reviewed, putting an accent on its novel multiple modality of action.'] Does hydroxypropyl-guar gellable lubricant eye drop for dry eye treatment?