['To determine whether elevated serum lipid levels resulting from feeding animals a high-fat diet can affect the inflammatory process in C57BL/6 (B6) wild-type (WT) and B6 ApoE(-/-) mouse models of collagen-induced arthritis (CIA).', "Male B6 WT or ApoE(-/-) mice were fed either a normal chow diet or a high-fat diet. CIA was induced in mice at 12 weeks of age using type II chicken collagen, Freund's complete adjuvant, and, on occasion, a lipopolysaccharide boost. Expression levels of autoantibodies and cytokines were measured using enzyme-linked immunosorbent assay and multiplex assay, respectively.", 'Whereas B6 WT mice developed severe articular inflammation after collagen immunization, ApoE(-/-) mice developed no clinical or histologic evidence of disease regardless of whether they had been fed a high-fat diet or a normal chow diet. The fact that arthritis was not present in ApoE(-/-) mice did not result from inadequate production of serum IgG2a collagen antibodies, since levels observed in ApoE(-/-) mice were similar to those observed in arthritic B6 WT control mice. Critically, development of atherosclerosis in ApoE(-/-) mice was not affected by the CIA protocol.'] Are apolipoprotein E-deficient mice resistant to the development of collagen-induced arthritis?