['Carotid interventions are important in helping to reduce the risk of stroke for patients with high-grade carotid artery stenosis; however, subclinical cerebral microemboli can occur during these procedures. Associations have been found between the incidence of microemboli and postoperative decline in memory. We therefore sought to determine whether this decline persisted long-term and to assess changes in other cognitive domains.', 'Patients were prospectively recruited under an Institutional Review Board-approved protocol at a single academic center. Neuropsychological testing was administered preoperatively and at 1-month and 6-month intervals postoperatively. Cognitive domains that were evaluated included verbal memory, visual memory, psychomotor speed, dexterity, and executive function. Diffusion-weighted magnetic resonance imaging sequencing was performed preoperatively and ≤48\xa0hours postoperatively to identify procedure-related microemboli. Univariate and multivariate regression models were used to identify relationships among microembolization, demographics, and cognition.', 'Included were 80 male patients with an average age of 69\xa0years. Forty patients underwent carotid artery stenting and 40 underwent carotid endarterectomy. Comorbidities included diabetes in 45%, coronary artery disease in 50%, and prior neurologic symptoms in 41%. New postoperative microemboli were found in 45 patients (56%). Microembolization was significantly more common in the carotid artery stenting cohort (P\xa0< .005). Univariate analysis demonstrated that patients with procedurally related embolization showed decline 1\xa0month postoperatively in verbal memory and Trail Making A measures. Multivariate analysis demonstrated that procedurally related embolization (odds ratio [OR], 2.8; P\xa0= .04) and preoperative symptomatic stenosis (OR, 3.2; P\xa0= .026) were independent predictors of decline for the Rey Auditory Verbal Learning Test Short Delay measure at 1\xa0month. At 6\xa0months, no significant relationship was found between emboli and decline on Rey Auditory Verbal Learning Test Short Delay, but age (OR, 1.1, P\xa0= .005) and chronic obstructive pulmonary disease (OR, 7.1, P\xa0= .018) were significantly associated with decline at 6\xa0months after the intervention.'] Is microembolization associated with transient cognitive decline in patients undergoing carotid interventions?