['To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism and alcoholism.', 'Genotyping to identify the polymorphisms in 515 alcoholic patients and 361 normal controls was performed.', 'There were no significant differences between the genotype and allele frequencies of the -357A/G polymorphism in alcoholics and normal controls. Linkage disequilibrium was observed between the promoter and exon 12 polymorphisms.'] Does aLDH2 promoter polymorphism have no effect on the risk for alcoholism?