['Video-assisted thoracic surgery (VATS) is widely used in thoracic surgery. This study investigated the usefulness of the subxiphoid approach in thymectomy using VATS techniques.', 'Sixty operations were performed using the lateral approach (n\xa0=\xa046) and subxiphoid approach (n\xa0=\xa014). Using the lateral approach, 39 partial thymectomies (PT), 5 total or subtotal thymectomies (TT), and 2 total or subtotal thymectomies with combined resection of the surrounding organs (or tissues) (CR) were performed. Using the subxiphoid approach, 11 TT and 3 CR were performed.', 'There were 33 females and 27 males, with a mean age of 55\xa0years. The mean maximum tumor diameter was 4.0\xa0cm. The operation time was prolonged according to the volume of thymectomy (PT: 119, TT: 234, CR: 347\xa0min). Additionally, the intraoperative blood loss increased according to the volume of thymectomy (PT: 29, TT: 47, CR: 345\xa0g). To compare the invasiveness of both approaches, we compared 16 TT operations. In the group using the subxiphoid approach, the operation time became shorter (158 vs. 392\xa0min), and the blood loss decreased (5 vs. 135\xa0g) compared with the lateral approach. Regarding laboratory data, white blood cell counts on postoperative day 1 (1POD) (8200 vs. 10,300/μl) and CRP on 1POD and 3POD (2.8 and 2.8 vs. 7.9 and 10.2\xa0mg/dl, respectively) decreased in the subxiphoid approach compared with the lateral approach.'] Does the Subxiphoid Approach lead to Less Invasive Thoracoscopic Thymectomy Than the Lateral Approach?