['Previous studies on type 2 diabetes have shown an association between exercise capacity and insulin resistance. In patients with coronary artery disease (CAD) exercise capacity is often reduced due to exercise-induced ischemia. We have investigated the association between glucometabolic control, including the homeostatic model assessment (HOMA) of insulin resistance, and exercise capacity in patients with type 2 diabetes and CAD with and without exercise-induced ischemia.', 'In 137 patients (age 63.1\u2009±\u20097.9) cardiopulmonary exercise testing on treadmill was performed using a modified Balke protocol. The highest oxygen uptake (VO2peak) was reported as 30-s average. Fasting blood samples were drawn for determination of glucose, insulin and HbA1c. Insulin resistance (IR) was assessed by the HOMA2-IR computer model. Exercise-induced ischemia was defined as angina and/ or ST-depression in ECG\u2009≥\u20090.1 mV during the exercise test.', 'HOMA2-IR was inversely correlated to VO2peak (r\u2009=\u2009-0.328, p\u2009<\u20090.001), still significant after adjusting for age, gender, smoking and BMI. Patients with HOMA2-IR above the median value (1.3) had an adjusted odds ratio of 3.26 (95 % CI 1.35 to 7.83, p\u2009=\u20090.008) for having VO2peak below median (23.8 mL/kg/min). Insulin levels were inversely correlated to VO2peak (r\u2009=\u2009-0.245, p\u2009=\u20090.010), also after adjusting for age and gender, but not after additional adjustment for BMI. The correlation between HOMA2-IR and VO2peak was also significant in the subgroups with (n\u2009=\u200951) and without exercise-induced ischemia (n\u2009=\u200986), being numerically stronger in the group with ischemia (r\u2009=\u2009-0.430, p\u2009=\u20090.003 and r\u2009=\u2009-0.276, p\u2009=\u20090.014, respectively). Fasting glucose and HbA1c were not correlated with VO2peak or AT.'] Are insulin levels and HOMA index associated with exercise capacity in patients with type 2 diabetes and coronary artery disease?