['Fractional tissue oxygen extraction (FTOE) is a measure derived from cerebral near-infrared spectroscopy (NIRS) and simultaneous pulse oximetry (SpO', 'Infants born before <30 weeks and weighing <1500\u2009g underwent synchronized SpO', 'A total of 63 infants were included with a mean±s.d. gestational age of 25.8±1.5 weeks and birth weight of 898.5±206.9\u2009g; 13/63 (20%) had severe ROP. SpO'] Is early hyperoxia burden detected by cerebral near-infrared spectroscopy superior to pulse oximetry for prediction of severe retinopathy of prematurity?