["Previous studies of HLA and Hashimoto's thyroiditis have shown weak associations between the disease and various HLA-DR antigens.", "To define better the contribution of HLA class II alleles to susceptibility to Hashimoto's thyroiditis.", "Comparison of HLA-DRB, DQA and DQB restriction fragment length polymorphisms in patients with Hashimoto's thyroiditis and control subjects, and meta-analysis of this and other published studies.", "Fifty Caucasian patients with Hashimoto's thyroiditis and 93 racially-matched control subjects.", 'A 4.6 kb Taq 1 DQA restriction fragment length polymorphism occurred in 60% of patients compared with 35.5% of controls, Pc < 0.025. No other restriction fragment length polymorphism was significantly associated with the disease. Meta-analysis of several studies demonstrated weak, positive associations between the disease and DR3 and DR4. An association with DR5 was not significant.'] Does hLA class II gene polymorphism contribute little to Hashimoto 's thyroiditis?