['A higher plasma aldosterone-renin ratio (ARR) is an established marker for screening for primary aldosteronism (PA). The association between higher ARR and mortality in a general population has not been fully explored. We here examined whether higher ARR is a risk factor for total and cause-specific mortality in a Japanese population.', 'A population-based, longitudinal study of 1,310 Japanese individuals (age: 63·9\xa0±\xa09·8\xa0years) enrolled in the Takahata study between 2004 and 2006 and followed for up to 8\xa0years. The incidence and causes of death were monitored annually until 10 January 2012 (median follow-up: 2691\xa0days).', "During the follow-up period, 64 subjects died. Kaplan-Meier analysis showed a significantly increased risk for total and cancer mortality in subjects with lower ARR (log-rank P\xa0<\xa00·001). Cox's proportional hazard model analyses with adjustment for age and gender showed that lower ARR was associated with increased total and cancer mortality in subjects with low (≦72) vs high (>72) ARR (hazard ratios and 95% confidential intervals: 2·56, 1·44-4·56 and 2·78, 1·16-6·65, respectively)."] Is lower aldosterone-renin ratio a risk factor for total and cancer death in Japanese individuals : the Takahata study?