['Cancer antigen-125 (CA-125) might be a useful biomarker to predict long-term mortality in patients with recent exacerbation of chronic obstructive pulmonary disease (COPD).', 'A total of 87 consecutive patients with COPD were evaluated prospectively. Mean age of patients was 68\u2009±\u200910 years (55% males, 45% females) with a median follow-up period of 49 months. Optimal cut-off value of CA-125 to predict mortality was found as >93.34\u2009U/ml, with 91% specificity and 40% sensitivity.', 'After follow-up, 20 out of 87 (23%) experienced cardiovascular death. CA-125 levels were higher among those who died compared to those who survived [55 (12-264) versus 28 (5-245) U/ml, p\u2009=\u20090.013]. In multivariate Cox proportional-hazards model with forward stepwise method, only CA-125\u2009>\u200993.34\u2009U/ml on admission (HR\u2009=\u20093.713, 95% CI: 1.035-13.323, p\u2009=\u20090.044) remained associated with an increased risk of death.'] Do cancer antigen-125 levels predict long-term mortality in chronic obstructive pulmonary disease?