In their first match up of the season versus division-leading rival Seattle Seahawks, the 49ers jumped to a 20-0 lead at halftime thanks to the combined efforts of running back Frank Gore and the defense. This was the first game back from injury for Seattle running back Shaun Alexander, and he was held to just 37 rush yards. On the other side of the ball, Frank Gore ran for a career-high 212 yards on his way to topping the 1,000-yard mark for the season. The Seahawks offense turned the ball over five times during the game, including three interceptions thrown by quarterback Seneca Wallace, two of which were picked off by San Francisco cornerback Walt Harris. Alex Smith, 49ers quarterback, threw one touchdown pass and also rushed for a one-yard touchdown, the first rushing touchdown of his career. The win elevated the 49ers to a .500 record, and put them just one game out of first place in their division, behind the 6-4 Seahawks. On the final play of the game, a pass to Seattle's fullback Mack Strong, the Seahawks attempted to continue the play which was similar to The Play which made the Cal-Stanford rivalry famous. However 49ers Rookie Marcus Hudson recovered the lateral attempt and the game was over. In a reference to The Play, radio announcers on 107.7 The Bone declared "The band is NOT on the field". After the conclusion of the game, who was in second place within the divison?