['To investigate habitual sleep duration (HSD) and habitual sleep variability (HSV) in relation to abdominal obesity and nutrient intake as mediating factors in adolescents.', 'We analyzed data from 305 adolescents who participated in the Penn State Child Cohort follow-up examination. An actigraphy device was used for seven consecutive nights to calculate HSD and HSV. Abdominal obesity was assessed by dual-energy x-ray absorptiometry. The Youth/Adolescent Food Frequency Questionnaire was used to obtain daily total caloric, protein, fat, and carbohydrates intakes. Linear regression models were used to associate HSD and HSV with abdominal obesity and to qualitatively identify mediating factors. The mediating effect was quantitatively estimated by mediation models.', 'After adjusting for major covariates and HSD, higher HSV was significantly associated with abdominal obesity measures. For example, with 1-hour increase in HSV, android/gynoid fat ratio and visceral fat area increased by 0.02\u2009cm(2) (standard error\u2009=\u20090.01, p\u2009=\u20090.03) and 6.86\u2009cm(2) (standard error\u2009=\u20092.82, p\u2009=\u20090.02), respectively. HSD was not associated with abdominal obesity in HSV-adjusted models. Total caloric, fat, and carbohydrate intakes were significant mediating factors. For instance, 20% of the association between HSV and visceral fat can be attributed to carbohydrate intake.'] Is habitual sleep variability , mediated by nutrition intake , associated with abdominal obesity in adolescents?