['The goals of this study were to assess the feasibility and to characterize the foreign-body response of a long-term catheter in the pericardium.', 'Long-term access to the normal pericardial space provides opportunities for diagnostic sampling and therapeutic intervention.', 'After thoracotomy, in 7 anesthetized canines, the pericardium was opened and a 5 French silicone vascular access catheter was advanced 10 cm into the pericardial sac toward the apex of the heart. A hydraulic coronary balloon occluder was implanted (N=6). Pericardium was sealed with Prolene suture. Catheters were tunneled to the nape of the neck, attached to a subcutaneous vascular access port, and buried in the fascia. Animals underwent multiple experimental coronary artery occlusions across months. At sacrifice, we assessed the histopathological response of pericardium and epicardium to chronically indwelling silicone catheters.', 'Post-mortem examinations were performed at 213 days post-operatively (mean, range=96-413, N=6), with one animal maintained for longer-term study. At sacrifice, all catheters were bidirectionally patent and completely mobile in the pericardium without evidence of tissue overgrowth around the intrapericardial segment. Adhesion tissue was found only at the site of catheter entry through the pericardium. Microscopic histopathological examination at catheter entry site, surrounding pericardium, and myocardium revealed minimum chronic inflammation.'] Is long-term pericardial catheterization associated with minimum foreign-body response?