['Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation pattern associated with migraine. The aim of this study was to evaluate the influence of a positive familial history of migraine on VEP amplitude and habituation.', 'We recorded six blocks of 100 VEP during continuous pattern-reversal stimulation in 30 patients with migraine between attacks (MO) and in 30 healthy volunteers, of whom 15 had a first-degree relative suffering from migraine (HVm) and 15 had not (HV).', 'Both MO and HVm had a significant deficit of VEP habituation and similarly reduced N1-P1 first block amplitudes, compared to HV (habituation slope: MO\u2009=\u20090.033, HVm\u2009=\u20090.021, HV\u2009=\u2009-0.025, HV vs. MO p\u2009=\u20090.002, HV vs. HVm p\u2009=\u20090.036; mean N1-P1 amplitude in the first block: MO\u2009=\u20099.08\u2009µV, HVm\u2009=\u20099.29\u2009µV, HV\u2009=\u200912.19\u2009µV. HV vs. MO p\u2009=\u20090.041, HV vs. HVm p\u2009=\u20090.076). The first block N1-P1 amplitude was negatively correlated with the habituation slope for both MO (ρ\u2009=\u2009-.44, p\u2009=\u20090.015) and HVm (ρ\u2009=\u2009-.56, p\u2009=\u20090.031) while no significant correlation was found in HV (ρ\u2009=\u2009.17, p\u2009=\u20090.53). There were no differences in VEP latencies between the groups.'] Does familial history of migraine influence habituation of visual evoked potentials?