['The gene zinc finger homeobox 3 (ZFHX3) encodes a transcription factor with cardiac expression and its genetic variants are associated with atrial fibrillation (AF). We aimed to explore the associations between single nucleotide polymorphisms (SNPs) of ZFHX3 and the risk of AF in a Chinese Han population.', 'We genotyped eight SNPs, including seven potentially functional SNPs and one previously reported SNP by using the middle-throughput iPLEX Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models.', 'We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 non-AF controls. Logistic regression analyses revealed that potentially functional SNPs rs6499600 and rs16971436 were associated with a decreased risk of AF (adjusted OR \u200a=\u200a0.73, 95% CI: 0.63-0.86, P\u200a=\u200a1.07×10-4; adjusted OR \u200a=\u200a0.74, 95% CI: 0.56-0.98, P\u200a=\u200a0.039, respectively). In addition, rs2106261 showed a robust association with an increased risk of AF (adjusted OR \u200a=\u200a1.71, 95% CI: 1.46-2.00, P\u200a=\u200a1.85×10-11). After multiple comparisons, rs16971436 conferred a borderline significant association with the risk of AF. Stratification analysis indicated that the risks of AF were statistically different among subgroups of age for rs2106261, and the effect for rs16971436 was more evident in subgroups of patients with coronary artery disease.'] Are genetic polymorphisms in ZFHX3 associated with atrial fibrillation in a Chinese Han population?