['Few trials have explored the effect of nutrition support on quality of life (QoL). This study examined the effects of oral nutritional supplements (ONS) vs dietary advice on QoL in malnourished care home residents.', "104 malnourished, care home residents (medium\xa0+\xa0high risk), identified using the Malnutrition Universal Screening Tool ('MUST'), (mean age 88.5\xa0±\xa07.9y) were randomised to receive either oral nutritional supplements (ONS) (n\xa0=\xa053) or dietary advice (n\xa0=\xa051) for 12 weeks. Dietary intake was measured using 24\xa0h\xa0dietary recall, and QoL assessed using EuroQol (EQ-5D), including time trade off (TTO) (range\xa0-0.59 to 1) and visual analogue scale (VAS) (score 0 to 100) for self-perceived health.", 'QoL (adjusted for baseline QOL, malnutrition risk, type of care received (nursing or residential)) was significantly higher in the ONS than the dietary advice group (intention to treat analysis at week 12; n\xa0=\xa0104 ). EQ-5D TTO scores (mean\xa0±\xa0SE) were 0.50\xa0±\xa00.04 vs 0.36\xa0±\xa00.05 (P\xa0=\xa00.005), VAS rescaled scores were 0.54\xa0+\xa00.03 vs 0.046\xa0+\xa00.03 (P\xa0=\xa00.006) and VAS scores were 61.3\xa0±\xa04.5 vs 54.6\xa0±\xa06.3 (P\xa0=\xa00.533) for ONS vs dietary advice respectively. Total energy, protein and the majority of micronutrient intakes were significantly greater in the ONS group, with energy intake being 423\xa0kcal greater in the ONS than the dietary advice group at week 12.'] Are oral nutritional supplements in a randomised trial more effective than dietary advice at improving quality of life in malnourished care home residents?