['Vascular endothelial growth factor-C (VEGF-C), a lymphatic vessel growth factor, has been involved in the formation of lymph nodal metastases in different tumor types. Early evidences indicate that VEGF-C expression in human primary melanoma could be predictive of lymph nodal metastases, whereas the role of lymphangiogenesis is still controversial.', 'By immunohistochemical analysis, we investigated VEGF-C or CC chemokine receptor 7 expression, together with the lymphatic and blood vessel network, in 36 patients with primary skin melanomas and metastases at the sentinel lymph node biopsy (SLN-positive), and 26 melanoma patients with negative SLN biopsy (SLN-negative).', 'We found that VEGF-C expression in primary melanoma specimens was significantly associated with SLN-positive (p\u2009<\u20090.001), particularly in thin melanomas. An association between augmented peritumoral lymphatic vessel area and SLN-positive (p\u2009<\u20090.02) was also seen. Conversely, no association between either expression of the CC chemokine receptor 7 in the primary tumor, or intratumoral lymphatic vessel or peritumoral and intratumoral blood vessel area, and SLN-positive was found.'] Does expression of vascular endothelial growth factor-C in primary cutaneous melanoma predict sentinel lymph node positivity?