['We evaluated the rate of late recanalisation beyond 24\xa0h after intravenous thrombolysis (IVT) and its relationship with haemorrhagic transformation and outcome.', 'We reviewed prospectively collected clinical and imaging data from acute ischaemic stroke patients with distal internal carotid artery or proximal middle cerebral artery occlusion who underwent angiography on admission, 24\xa0h and 1\xa0week after IVT. Patients were trichotomised according to vascular status: timely recanalisation (<24\xa0h), late recanalisation (24\xa0h-7\xa0days), and no recanalisation.', 'Non-invasive angiography revealed timely recanalisation in 52 (50.0\xa0%) patients, late recanalisation in 25 (24.0\xa0%) patients, and no recanalisation in 27 (26.0\xa0%) patients. Pre-existing atrial fibrillation was associated with the occurrence of late recanalisation (odds ratio 6.674; 95\xa0% CI: 1.197 to 37.209; p\u2009=\u20090.030). In patients without timely recanalisation, shift analysis indicated that late recanalisation led to a worse modified Rankin Scale score (odds ratio 6.787; 95\xa0% CI: 2.094 to 21.978; p\u2009=\u20090.001).'] Is late recanalisation beyond 24 hours associated with worse outcome : an observational study?