['It remains unclear whether intrahepatic angiogenesis increases portal hypertension (PH) in hepatitis B with cirrhosis. We aim to investigate the relationship between intrahepatic angiogenesis and PH in hepatitis B patients with cirrhosis.', '60 hepatitis B patients with cirrhosis and 40 healthy subjects were included in this study. Angiogenesis markers vascular endothelial growth factor receptor-2 (VEGFR2), von Willebrand Factor (vWF), and fibrosis marker alpha-smooth muscle actin (α-SMA) were observed by immunohistochemistry. Sirius-Red staining was also used to determine liver fibrosis. Correlations between levels of intrahepatic angiogenesis and Child-Pugh classes, liver fibrosis degree, portal vein pressure were examined. We also analyzed the relationship between levels of intrahepatic angiogenesis and complications of PH, including esophageal varices(EV), ascites and hypersplenism.', 'Correlation was observed between the levels of VEGFR2 (r\u2009=\u20090.590, p\u2009<\u20090.01), vWF (r\u2009=\u20090.524, p\u2009<\u20090.01) in tissue and Child-Pugh classes, respectively. Significant correlations were observed between levels of VEGFR2 and a-SMA (r\u2009=\u20090.710, p\u2009<\u20090.01), VEGFR2 and Sirius-Red (r\u2009=\u20090.841, p\u2009<\u20090.01), vWF and a-SMA(r\u2009=\u20090.768, p\u2009<\u20090.01), vWF and Sirius-Red (r\u2009=\u20090.825, p\u2009<\u20090.01). Patients with hepatic venous pressure gradient (HVPG)\u2009≥\u200912\u2009mmHg showed higher levels of VEGFR2 and vWF expression compared to those who with HVPG\u2009<\u200912\u2009mmHg (2.60\u2009±\u20091.28%vs.1.09\u2009±\u20090.73%; 5.85\u2009±\u20092.45%vs.2.31\u2009±\u20091.34%, p\u2009<\u20090.01), respectively. Moreover, complications of PH, including size of EV (p <0.01), presence of ascites (p\u2009<\u20090.01) and spleen volume (p\u2009<\u20090.01) were significantly affected by the levels of intrahepatc angiogenesis.'] Does intrahepatic angiogenesis increase portal hypertension in hepatitis B patients with cirrhosis?