['This pilot trial was designed to determine if an optimal dose of Technosphere(®) insulin (TI) inhalation powder (MannKind Corp., Valencia, CA) could be used regardless of variation in meal carbohydrate (CHO) content.', 'In total, eight subjects (seven men, one woman) with type 2 diabetes were enrolled. Subjects underwent dose optimization meal challenge (MC) visits (100% CHO) and MCs with varied CHO meal contents (50%, 200%, and 0% calculated CHOs). Primary end point was change in postprandial glucose (PPG) excursions. Baseline demographics were 60±7 years of age, diabetes duration of 12.3±4.27 years, hemoglobin A1c (A1C) of 7.82±1.04%, and body mass index of 31.3±5.48 kg/m(2).', 'Maximum mean PPG excursions for the nominal 100% CHO meals were -13±15\u2009mg/dL for breakfast (B) and -14±15\u2009mg/dL for lunch (L), similar to those after 50% CHO meals (B, -17±16\u2009mg/dL; L, +14±10\u2009mg/dL). The largest excursions occurred during 200% CHO meals and remained below American Diabetes Association targets (B, +19±16\u2009mg/dL; L, +32±29\u2009mg/dL). During 15 of the MCs, subjects took their usual TI dose and then had no meal (0% CHO). For the 0% CHO MCs, the largest mean PPG excursion were -33±9\u2009mg/dL at 60\u2009min (B) and -31±10\u2009mg/dL at 60 and 90\u2009min (L). Mean A1C dropped from 7.82±1.04% at the Week 1 visit to 6.18±0.46% (P=0.00091) at the Week 19 visit.'] Does technosphere insulin effectively control postprandial glycemia in patients with type 2 diabetes mellitus?