Coming off their win over the Rams the 49ers played on home ground for an NFC duel with the Buccaneers. In the second quarter the 49ers trailed after RB Cadillac Williams made a 6-yard TD run. This was followed in the third quarter by QB Josh Freeman completing an 8-yard TD pass to WR Mike Williams; and in the fourth quarter by Freeman throwing a 1-yard TD pass to Donald Penn. With the loss, the 49ers fell to 3-7.  This marked the 49ers' first shutout loss at home since 1977, when they were defeated by the Atlanta Falcons 7-0.. Who scored a touchdown earlier, Cadillac Williams or Mike Williams?