['Orthostatic hypotension is increasingly reported as a risk factor for development of late-stage disease features in Parkinson disease (PD). Less is known about its significance in individuals with early PD who are often targeted for neuroprotective trials.', "Using data from the CALM-PD trial (n\xa0=\xa0275), we explored whether early orthostatic hypotension predicts a decline in the Unified Parkinson's Disease Rating Scale (UPDRS) II (activities of daily living) or UDPRS III (motor) score after 102 weeks. We also explored risk factors for worsening orthostatic hypotension over a nearly 2-year period.", 'After controlling for age, disease duration, gender, study drug, change in mini-mental status exam score, levodopa equivalent dose, and baseline UPDRS II or III score respectively, the degree of orthostatic hypotension at enrollment associated with a worsening in UPDRS motor score (t\xa0=\xa02.40, p\xa0=\xa00.017) at week 102 but not with UPDRS ADL score (t\xa0=\xa00.83, p\xa0=\xa00.409). Worsening in orthostatic hypotension during the study associated with longer disease duration (t\xa0=\xa02.37, p\xa0=\xa00.019) and lower body mass index (BMI) (t\xa0=\xa0-2.96, p\xa0=\xa00.003).'] Does orthostatic hypotension predict motor decline in early Parkinson disease?