['To evaluate whether differences in follicular fluid vascular endothelial growth factor (FF VEGF) concentrations are observed between women achieving a clinical pregnancy and those failing to conceive.', 'Retrospective chart review and analysis of FF VEGF concentrations.', 'University teaching center.', 'Fifty-seven women < or =42 years of age undergoing follicular aspiration in preparation for IVF or GIFT.', 'Analysis of FF VEGF concentrations and chart review of a single IVF or GIFT cycle.', 'Follicular fluid VEGF concentrations, clinical pregnancy rate, age, ampules of gonadotropins used, oocytes retrieved, peak estradiol serum concentrations, day 3 FSH levels, and fertilization rate.', "Women who did not conceive had higher FF VEGF concentrations than women achieving a clinical pregnancy (4.409 + 2,387 versus 2.793 +/- 1,180 pg/mL: P < .001). A negative correlation was observed between FF VEGF concentrations and peak estradiol levels and number of oocytes retrieved. A positive correlation was found for FF VEGF and patient's age and ampules of gonadotropins used."] Is elevated level of follicular fluid vascular endothelial growth factor a marker of diminished pregnancy potential?