After a disappointing loss to Seattle the Patriots traveled to Santa Clara, CA to face Tom Brady's childhood team, the San Francisco 49ers, who were on an eight-game losing streak. This was also the first time Brady played the 49ers in San Francisco, as he missed the Patriots' trip to Candlestick Park in 2008 as a result of an injury. After a 49ers three-and-out, Amendola returned the punt 30 yards to the 49ers 27. Six plays later, Brady hit Edelman on a 7-yard touchdown pass, but Gostkowski missed the extra point. The 49ers drove all the way to the Patriots 6 on their next drive, but Hightower sacked Colin Kaepernick for a 9-yard loss on 3rd-down and they were forced to settle for a 33-yard field goal by Phil Dawson. The Patriots countered on their next drive, racing 77 yards in just 6 plays, scoring on Brady's 9-yard touchdown pass to James White, increasing the lead to 13-3. Two possessions later, the 49ers raced 92 yards in just over four minutes, scoring on an 18-yard touchdown catch by Vance McDonald, trimming the deficit to 13-10. After both teams punted, the Patriots drove to the 49ers 41, but White couldn't get out of bounds in time after a 25-yard catch, and the Patriots led 13-10 at halftime. After the first four possessions of the second half ended in punts, the Patriots marched 80 yards in 10 plays, scoring on Brady's 5-yard connection to Amendola, increasing the lead to 20-10. Three possessions later, Brady found Mitchell for a 56-yard touchdown pass as Brady was falling down, capping off a 70-yard drive, upping the lead to 27-10. After a 49ers three-and-out, the Patriots kept pouring it on, driving all the way to the 49ers 20, and Gostkowski added a 38-yard field goal, widening the lead to 30-10. The Niners marched 75 yards on their next drive, scoring on Kaepernick's 13-yard touchdown pass to Shaun Draughn, trimming the deficit to 30-17. Amendola recovered the ensuing onside kick and the Patriots ran out the rest of the clock to end the game. The Patriots improved to 8-2. Running back LeGarrette Blount had a big day as he rushed for a total of 125 yards on 19 carries. In addition, Tom Brady also had a big day passing for a total of 4 touchdowns against the 49ers. This was also Brady's 199th career win (regular season and postseason combined), tied with Brett Favre for second place.. Which player had the longest touchdown reception of the game?