['Chemotherapy-induced mucositis is characterised by damage to mucous membranes throughout the alimentary tract. This study aims to investigate the expression of cell adhesion molecules (CAMs) following treatment with irinotecan.', 'Dark agouti rats received a single dose of 175\xa0mg/kg irinotecan and sacrificed at various time points after treatment. Picro-sirius red staining indicated an increase in collagen around crypts from 24\xa0h in both small and large intestinal regions and this diminished at the later time points. CAMs E-cadherin, P-selectin, E-selectin and integrin-α1 were examined using immunohistochemistry.', 'E-cadherin was significantly elevated in jejunal crypts at the time of maximal tissue damage (48\xa0h), while it decreased at the healing phase (96\xa0h) in both jejunum and colon. P-selectin expression decreased significantly in the jejunum following irinotecan. Crypt expression of E-selectin was significantly elevated in the healing phase of mucositis (96\xa0h). Integrin-α1 expression was significantly altered during the time course in the villus (p\xa0=\xa00.0032) and lamina propria (p\xa0=\xa00.039).'] Are cell adhesion molecules altered during irinotecan-induced mucositis : a qualitative histopathological study?