['The aim of this study was to evaluate the effect of the Topping-off technique in preventing the aggravation of degeneration caused by adjacent segment fusion.', 'Clinical parameters of patients who underwent L5-S1 posterior lumbar interbody fusion\u2009+\u2009interspinous process at L4-L5 (PLIF\u2009+\u2009ISP) with the Wallis system (Topping-off group) were compared retrospectively with those of patients who underwent solely PLIF. Pre- and post-operative x-ray measurements, visual analogue scale (VAS) scores, and Japanese Orthopaedic Association (JOA) scores were assessed in all subjects. Normal L1-S1 lumbosacral finite element models were established in accordance with the two types of surgery in our study, respectively. Virtual loading was added to assess the motility, disc pressure, and facet joint stress of L4-L5.', 'There were 22 and 23 valid cases included in the Topping-off and PLIF groups. No degeneration was observed in either group. Both VAS and JOA scores improved significantly post-operatively (P\u2009<\u20090.01). The intervertebral angle and lumbar lordosis of L4-L5 were both significantly increased (t\u2009=\u2009-2.89 and -2.68, P\u2009<\u20090.05 in the Topping-off group and t\u2009=\u2009-2.25 and -2.15, P\u2009<\u20090.05 in the PLIF group). In the Topping-off group, x-ray in dynamic position showed no significant difference in the angulation or distance of the anterior movement of the L4-L5 segment. The angle of hyper-extension and distance of the posterior movement of L4 were significantly decreased. In the PLIF group, both hyper-flexion and hyper-extension and posterior movement were increased significantly. In finite element analysis, displacement of the L4 vertebral body, pressure of the annulus fibrosus and nucleus pulposus, and stress of the bilateral facet joint were less in the Topping-off group under loads of anterior flexion and posterior extension. Facet joint stress on the left side of the L4-L5 segment was also less in the Topping-off group under left flexion loads.'] Does topping-off technique prevent aggravation of degeneration of adjacent segment fusion revealed by retrospective and finite element biomechanical analysis?