['To evaluate the effect of adding butylscopolammonium bromide (BB) to morphine and ketorolac in the treatment of acute renal colic in the ED.', 'A prospective, double-blind, randomized controlled trial of i.v. triple therapy (morphine, ketorolac and BB) versus double therapy (morphine and ketorolac) in adult ED patients with a clinical diagnosis of acute renal colic and a pain rating greater than five on a 10\u2003cm visual analogue scale (VAS). VAS was recorded at time 0, 20 and 40\u2003min. Patients received rescue morphine at 20 or 40\u2003min according to the protocol if needed. We compared pain reduction and the need for rescue analgesia at 4\u2003min between two groups.', 'Eighty-nine patients were randomized over a 13\u2003month period. A total of 46 (51.7%) patients received BB in addition to morphine and ketorolac. The mean difference in change in pain score in the triple therapy group and double therapy group was 7.1\u2003cm (95% CI 6.4-7.8) and 5.9\u2003cm (95% CI 5.1-6.7), respectively (P= 0.024). Rescue morphine was required by 7/46 (15.2% [95% CI 4.4-20.6]) patients in the triple therapy group and 14/43 (32.6% [95% CI 18.0-47.1]) in the double therapy group (OR 0.37 [95% CI 0.133-1.038]).'] Does butylscopolammonium bromide provide additional analgesia when combined with morphine and ketorolac for acute renal colic?