['The mechanisms underlying rapamycin-induced Akt phosphorylation have not been fully elucidated.', 'Inhibition of PP2A or DNA-PK attenuates or abrogates rapamycin-induced Akt phosphorylation and co-inhibition of mTOR and DNA-PK enhances anticancer activity.'] Are protein phosphatase 2A and DNA-dependent protein kinase involved in mediating rapamycin-induced Akt phosphorylation?