['Behavioral experiments have demonstrated that the sensory modality of presentation modulates drug cue reactivity.', 'The present study on nicotine addiction tested whether neural responses to smoking cues are modulated by the sensory modality of stimulus presentation.', 'We measured brain activation using functional magnetic resonance imaging (fMRI) in 15 smokers and 15 nonsmokers while they viewed images of smoking paraphernalia and control objects and while they touched the same objects without seeing them.', 'Haptically presented, smoking-related stimuli induced more pronounced neural cue reactivity than visual cues in the left dorsal striatum in smokers compared to nonsmokers. The severity of nicotine dependence correlated positively with the preference for haptically explored smoking cues in the left inferior parietal lobule/somatosensory cortex, right fusiform gyrus/inferior temporal cortex/cerebellum, hippocampus/parahippocampal gyrus, posterior cingulate cortex, and supplementary motor area.'] Does sensory modality of smoking cues modulate neural cue reactivity?