['Telestroke networks offer an opportunity to increase tissue-type plasminogen activator use in community hospitals.', 'We compared 83 patients treated with intravenous tissue-type plasminogen activator by telestroke to 59 patients treated after in-person evaluation by the same neurologists at a tertiary care stroke center. Onset and door-to-treatment times and functional outcome at 90 days were obtained prospectively. Favorable outcome was defined as modified Rankin Scale score ≤2.', 'Favorable outcome rates were comparable between the groups (42.1% versus 37.5%, P=0.7). There was no significant difference in the rate of symptomatic hemorrhage.'] Does telestroke-guided intravenous tissue-type plasminogen activator treatment achieve a similar clinical outcome as thrombolysis at a comprehensive stroke center?