['Ischemia-reperfusion injury causes chronic postischemia pain (CPIP), and rats with higher glycemia during ischemia-reperfusion injury exhibit increased allodynia. Glycemia-induced elevation of nuclear factor κB (NFκB) may contribute to increased allodynia.', 'Glycemia during a 3-h ischemia-reperfusion injury was manipulated by: normal feeding; or normal feeding with administration of insulin; dextrose; or insulin/dextrose. In these groups, NFκB was measured in ipsilateral hind paw muscle and spinal dorsal horn by enzyme-linked immunosorbent assay (ELISA), and SN50, an NFκB inhibitor, was administered to determine its differential antiallodynic effects depending on glycemia.', 'CPIP fed/insulin rats (12.03\u2009±\u20094.9 g, N = 6) had less allodynia than fed, fed/insulin/dextrose, and fed/dextrose rats (6.29\u2009±\u20093.37 g, N = 7; 4.57\u2009±\u20093.03\u2009g, N = 6; 2.95\u2009±\u20091.10 g, N = 9), respectively. Compared with fed rats (0.209\u2009±\u20090.022 AU, N = 7), NFκB in ipsilateral plantar muscles was significantly lower for fed/insulin rats, and significantly higher for fed/dextrose rats (0.152\u2009±\u20090.053 AU, N = 6; 0.240\u2009±\u20090.057 AU, N = 7, respectively). Furthermore, NFκB in the dorsal horn of fed, fed/insulin/dextrose, and fed/dextrose rats (0.293\u2009±\u20090.049 AU; 0.267 ± 0.037 AU; 0.315 ± 0.015 AU, respectively, N = 6 for each) was significantly higher than in fed/insulin animals (0.267\u2009±\u20090.037 AU, N = 6). The antiallodynic SN50 dose-response curves of CPIP rats in the fed/insulin/dextrose, fed/dextrose, and fed conditions exhibited a rightward shift compared with the fed/insulin group. The threshold SN50 dose of CPIP fed/dextrose, fed/insulin/dextrose, and fed rats (328.94\u2009±\u200992.4 ng, 77.80\u2009±\u200944.50 ng, and 24.89\u2009±\u200917.20 ng, respectively) was higher than that for fed/insulin rats (4.06\u2009±\u20097.04 ng).'] Does glycemia-dependent nuclear factor κB activation contribute to mechanical allodynia in rats with chronic postischemia pain?