["Rates of postoperative complications are particularly high among patients with Crohn's disease.", "The aim of this study was to assess whether positive inflammatory histological margins, among other factors, pose a risk for intra-abdominal septic complications in patients with Crohn's disease undergoing ileocolic resection.", 'A retrospective study of patient records, during 2000-2010, was conducted.', 'This investigation was performed at a single medical center.', "Included were 166 individuals with Crohn's disease (85 males, mean age 35.6).", 'Ileocolic resection with primary anastomosis was performed.', 'The primary outcomes measured were postoperative intra-abdominal septic complications.', 'Twenty-five patients (15%) developed intra-abdominal septic complications, including anastomotic leak, intra-abdominal abscesses and collections, and enterocutaneous fistulas. There were no postoperative deaths. Univariate analysis revealed that a long course of disease before surgery, an emergency surgery, steroid treatment of more than 3 months before surgery, additional sigmoidectomy, and positive surgical margins detected on histopathological examination were associated with intra-abdominal septic complications. In a multivariate analysis, only disease duration longer than 10 years (OR 4.575 (CI 1.592-13.142), p = 0.005), additional sigmoidectomy (OR 5.768 (CI 1.088-30.568), p = 0.04), and positive histological resection margins (OR 2.996 (CI 1.085-8.277), p = 0.03) were found to be independent risk factors.'] Are positive histological inflammatory margins associated with increased risk for intra-abdominal septic complications in patients undergoing ileocolic resection for Crohn 's disease?