["A single-nucleotide polymorphism (SNP) in GABRA2 (rs279858) may moderate subjective response (SR) to alcohol. Results of studies in non-dependent drinkers examining this GABRA2 SNP on SR have been equivocal. This study examined this SNP's direct and indirect effects on alcohol self-administration in dependent drinkers.", 'The sample consisted of 63 Caucasian, non-treatment-seeking individuals with alcohol dependence. Subjective stimulation was assessed using the Biphasic Alcohol Effects Scale following consumption of an alcoholic priming drink (target\xa0breath alcohol content\xa0=\xa00.02\u2009g%). Participants were subsequently offered the opportunity to self-administer up to eight additional drinks.', 'Controlling for baseline stimulation, T-allele homozygotes, relative to individuals with at least one copy of the C-allele, reported greater initial stimulation, t(58)\xa0=\xa02.011, p\xa0=\xa00.049. Greater stimulation predicted greater subsequent alcohol self-administration, t(57)\xa0=\xa02.522, p\xa0=\xa00.015. Although rs279858 genotype did not directly impact self-administration (t(57)\xa0=\xa0-0.674, p\xa0=\xa00.503), it did have an indirect effect (95% confidence interval [0.068, 1.576]), such that T-allele homozygotes reported greater stimulation, which in turn predicted greater self-administration.'] Does alcohol-Induced Stimulation mediate the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals?