["Data on metastatic Ewing's sarcoma family of tumours (ESFT) with uniform chemotherapy protocol are minimal.", 'This was a single institutional patient review of patients treated between June 2003 and November 2011 and evaluated on an intent-to-treat analysis. All patients received uniform chemotherapy: neoadjuvant chemotherapy (NACT), surgery and/or radiotherapy as local treatment followed by adjuvant chemotherapy. Local treatment was offered if the patient achieved a complete response and/or a partial response at both the primary and the metastatic site.', 'In total, 150/374 (40%) ESFT patients were metastatic, with a median age of 15 years (range: 2-50); a tumour diameter of 10\xa0cm (range: 1.8-26). Most common metastatic sites were lung only (53; 35%), bone only (35; 23%) and combined bone/lung (25; 17%). Twenty patients underwent surgery; 55 patients received radical radiotherapy after NACT. After a median follow-up of 26.1 months (range: 1.6-101.6), 5 year event-free survival (EFS), overall survival and local control rate (LCR) were 9.1\xa0±\xa03.3%, 16.9\xa0±\xa05.2% and 31.8\xa0±\xa07.9%, respectively. Univariate analysis showed serum albumin ≤3.4\xa0g/dl (P\xa0<\xa00.001) to predict inferior EFS. Tumour size >8\xa0cm (P\xa0=\xa00.05), haemoglobin ≤10\xa0g/dl (P\xa0=\xa00.04), hypoalbuminaemia (P\xa0=\xa00.003) and radical radiotherapy as local treatment (P\xa0=\xa00.03) predicted inferior overall survival. No factor significantly predicted LCR, although age ≤15 years (P\xa0=\xa00.08) and radical radiotherapy as local treatment (P\xa0=\xa00.09) had a trend towards inferior LCR. Hypoalbuminaemia was the only prognostic factor to predict EFS on multivariate analysis.'] Is hypoalbuminaemia an independent predictor of poor outcome in metastatic Ewing 's sarcoma family of tumours : a single institutional experience of 150 cases treated with uniform chemotherapy protocol?