['Application of multifrequency magnetic resonance elastography (MMRE) of the brain parenchyma in patients with neuromyelitis optica spectrum disorder (NMOSD) compared to age matched healthy controls (HC).', '15 NMOSD patients and 17 age- and gender-matched HC were examined using MMRE. Two three-dimensional viscoelastic parameter maps, the magnitude |G*| and phase angle φ of the complex shear modulus were reconstructed by simultaneous inversion of full wave-field data in 1.9-mm isotropic resolution at 7 harmonic drive frequencies from 30 to 60\xa0Hz.', 'In NMOSD patients, a significant reduction of |G*| was observed within the white matter fraction (p\u2009=\u20090.017), predominantly within the thalamic regions (p\u2009=\u20090.003), compared to HC. These parameters exceeded the reduction in brain volume measured in patients versus HC (p\u2009=\u20090.02 whole-brain volume reduction). Volumetric differences in white matter fraction and the thalami were not detectable between patients and HC. However, phase angle φ was decreased in patients within the white matter (p\u2009=\u20090.03) and both thalamic regions (p\u2009=\u20090.044).'] Does multifrequency magnetic resonance elastography of the brain reveal tissue degeneration in neuromyelitis optica spectrum disorder?