['To investigate the role of stomatin-like protein 2 (SLP-2), a novel cancer-related gene, in pulmonary squamous cell carcinoma (PSCC) and its implications.', 'Immunohistochemical detection of SLP-2 was performed on 96 cases of PSCC with a tissue microarray.', 'SLP-2 was overexpressed in lung cancer compared with normal lung tissue (p <0.001). High-level SLP-2 expression was significantly correlated with distant metastasis (p = 0.025), decreased overall survival (p = 0.018) and disease-free survival (p = 0.017). SLP-2 overexpression was an independent prognostic factor in multivariate analysis using the Cox regression model (p <0.05).'] Is sLP-2 overexpression associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma?