['It is suggested that maternal obesity perpetuates offspring obesity to future generations.', 'To determine whether location of neonate fat mass (FM: central vs. peripheral) is related to total neonate FM and whether maternal obesity influences this relationship.', 'Neonate body composition and skin-fold thicknesses were assessed in healthy neonates (n\u2009=\u2009371; 1-3 days old). Linear regression models examined the relationship between total FM and location of FM (central vs. peripheral). Location of FM was calculated by skin-folds: peripheral was the sum of (biceps and triceps)/2 and central was represented by the subscapular skin-fold.', 'A significant interaction was found for location of FM and maternal obesity. Holding all predictors constant, in offspring born to non-obese mothers, a 0.5\u2009mm increase in central FM predicted a 15\u2009g greater total FM, whereas a 0.5\u2009mm increase in peripheral FM predicted a 66\u2009g greater total FM. However, in offspring born to obese mothers, a 0.5\u2009mm increase in central FM predicted a 56\u2009g total FM, whereas a 0.5\u2009mm increase in peripheral FM predicted a 14\u2009g greater total FM.'] Does maternal obesity influence the relationship between location of neonate fat mass and total fat mass?