['Associations have been described between insulin action and long-chain omega6 polyunsaturated fatty acids in skeletal muscle and erythrocytes of healthy individuals. We evaluated whether there was an association between insulin resistance and long-chain omega6 polyunsaturated fatty acids in erythrocyte phospholipids of type 2 diabetics.', 'Erythrocyte phospholipid fatty acid composition was determined in 43 adult non-obese type 2 diabetics. Insulin resistance was estimated by the HOMA mathematical approximations. Individual omega6 fatty acids and the sum of long-chain omega6 polyunsaturated fatty acids were correlated with insulin resistance. The same association was assessed for fatty acid product/precursor ratios taken as measures of Delta5 desaturase, Delta6 desaturase and their combined action.', 'Except for 18:2omega6, 20:2omega6 and 20:3omega6, the individual omega6 fatty acids tested and the sum of long-chain omega6 polyunsaturated fatty acids correlated negatively with insulin resistance at p<0.005. Likewise, a negative correlation was found for the combined action of Delta5 and Delta6 desaturases (p<0.005).'] Are long-chain omega6 polyunsaturated fatty acids in erythrocyte phospholipids associated with insulin resistance in non-obese type 2 diabetics?