['Caloric restriction (CR) prevents senescent changes, in which reactive oxygen species (ROS) have a critical role. Left ventricular (LV) hypertrophy is a risk factor for cardiovascular diseases. We examined whether CR alters cardiac redox state and hypertrophy from chronic pressure overload.', 'Male c57BL6 mice were subjected to ascending aortic constriction (AAC) with ad libitum caloric intake (AL\xa0+ AAC group) or 40% restricted caloric intake (CR\xa0+ AAC group). CR was initiated 2 weeks before AAC and was continued for 4 weeks. Two weeks after constriction, AAC increased LV wall thickness, impaired transmitral flow velocity, and augmented myocyte hypertrophy and fibrosis, in association with enhancement of BNP and collagen III expressions in the AL\xa0+ AAC group. In the AL\xa0+ AAC group, oxidative stress in cardiac tissue and mitochondria were enhanced, and NADPH oxidase activity and mitochondrial ROS production were elevated. These changes were significantly attenuated in the CR\xa0+ AAC group. Additionally, in antioxidant systems, myocardial glutathione peroxidase and superoxide dismutase activities were enhanced in the CR\xa0+ AAC group.'] Does short-Term Caloric Restriction suppress Cardiac Oxidative Stress and Hypertrophy Caused by Chronic Pressure Overload?