In the middle of the 21st century, China will become a powerful country in science and technology, and the construction of science and culture will play a very important role in this historical process. In this regard, we need to strengthen cultural self-confidence. Cultural self-confidence is not only reflected in recognition of past cultural contributions and values In addition, it is more manifested in the confidence and determination to integrate various high-quality cultural resources and create a new culture. Although it is necessary to fully explore and inherit the scientific factors in China's traditional culture, it is necessary to fully understand the contribution to scientific development in our history. However, it is even more necessary to think about how to make new achievements that have made important contributions to the world in future scientific development and scientific and cultural construction. This should be a more important aspect of enhancing cultural self-confidence. The text mainly says:. ['Cultural self-confidence is manifested in the integration and innovation of cultural resources.', 'Scientific and cultural development is the core of building a strong country with science and technology.', 'Criteria for judging the contribution of Chinese scientific development to the world.', 'Ways to Enhance Cultural Confidence in the Construction of Science and Culture.']