['Small ubiquitin-like modifiers (SUMO) are covalently conjugated to other proteins including nuclear receptors leading to modification of various cellular processes.', 'Ligand-dependent SUMOylation of farnesoid X receptor (FXR) negatively regulates the expression of its target genes.'] Does sUMOylation of the farnesoid X receptor ( FXR ) regulate the expression of FXR target genes?