['Studies indicate that age is associated with deterioration in physical function and a concomitant decrease in health-related quality of life (HRQL). The contribution of physical function to HRQL in nonagenarians (ages 90-99) is unknown. The purposes of this study were to examine age-related changes in physical function and HRQL among community-dwelling nonagenarians and to determine the relationship between their physical function and HRQL.', 'Seventy-four community-dwelling nonagenarians participated. The Continuous Scale Physical Function Performance Test-10 (CS-PFP10) was used to measure their physical function and the Short Form (SF)-36 was used to measure their HRQL. Pearson correlations were used to assess associations among age, physical function, and HRQL scores.', 'Age was inversely associated with the upper body flexibility (r = -.365, p = .001) subscale of the CS-PFP10, but not significantly associated with any other physical function or HRQL score. Significant associations between physical function and HRQL were limited to those between upper body flexibility and the physical function subscale (r = .424, p < .001) and physical function component summary score (r = .376, p = .001) of the SF-36.'] Is age-related deterioration in flexibility associated with health-related quality of life in nonagenarians?