['Coronary artery heart disease (CAD) is a group of complex diseases, including coronary atherosclerosis, myocardial infarction and sudden cardiac death. CAD is also widely accepted as a chronic inflammatory disease. Studies show that pro-inflammatory TNF-α (tumor necrosis factor- alpha) is involved in the CAD pathological pathway and is a reliable predictor of cardiovascular disease. However, the association between TNF-α polymorphisms and CAD risk is still unclear. In this meta-analysis, we investigated the relationship between TNF-α polymorphisms and CAD risk.', '7525 articles from EMBASE, Web of science, EBSCO, PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were selected in our study. A meta-analysis on the associations between the T-1031C, C-857T and C-863A polymorphisms and CAD risk was carried out by comparing five genetic models.', 'In this systematic review 14 studies from 6 English articles and 1 Chinese article were analyzed. The pooled population included 16774 subjects (8351 cases and 8423 controls). Our results showed that three polymorphisms (T-1031C, C-857T and C-863A) have no association with CAD risk.'] Is there no association between TNF-α gene polymorphisms and the risk of coronary artery heart disease : a meta-analysis of 8351 cases and 8423 controls?