["Graves' disease (GD) is a common autoimmune disease triggered by genetic predisposition and environmental factors. However, the mechanisms of interaction between genetic and environmental factors contributing to the development of GD remain unknown.", 'To identify GD susceptibility variants and genes on Xq21.1 locus and interpret the contribution of interaction between genetic predisposition on Xq21.1 and environmental factors to GD.', 'We performed refining study on Xq21.1 in a two-stage study and carried out eQTL analysis of the best association signal with GD.', '4,316 GD patients and 4,374 sex-matched controls were collected from the Chinese Han population by cooperation with multiple hospitals.', 'We identified rs3827440 or its linkage SNPs was probably the causal variant in the Xq21.1 locus, with the most significant association with GD in our combined cohorts (P=2.45×10'] Does iTM2A expand Evidence for Genetic and Environmental Interaction in Graves ' Disease Pathogenesis?