['Sex steroid hormone receptors mediate essential processes in normal prostate growth and contribute to prostate cancer development.', 'In this study, we investigated the association between common inherited variation of the AR, ESR1, and ESR2 genes and two clinically relevant traits: the risk of developing aggressive prostate cancer and the response to androgen deprivation therapy (ADT) in a hospital-based cohort. A total of 43 tagging single nucleotide polymorphisms covering the loci of AR (n = 4), ESR1 (n = 32), and ESR2 (n = 7) were successfully genotyped in 4,073 prostate cancer cases.', "None of these single nucleotide polymorphisms were significantly associated with disease aggressiveness as assessed by the D'Amico risk classification, pathologic stage, or the response to ADT."] Are inherited variations in AR , ESR1 , and ESR2 genes associated with prostate cancer aggressiveness or with efficacy of androgen deprivation therapy?