['Asthma is one of the most common respiratory diseases worldwide, and the complexity of its etiology has been widely documented. Chromosome 5q31-33 is one of the main loci implicated in asthma and asthma-related traits. IL13, CD14 and ADRB2, which are located in this risk locus, are among the genes most strongly associated with asthma susceptibility.', 'This study evaluated whether single-nucleotide polymorphisms or haplotypes at 5q31-33 conferred risk for asthma in Mexican-Mestizo pediatric patients.', 'We performed a case-controlled study including 851 individuals, 421 of them affected with childhood-onset asthma and 430 ethnically matched unaffected subjects. We used the TaqMan Allelic Discrimination Assay to genotype 20 single-nucleotide polymorphisms within IL5, RAD50, IL13, IL4, CD14, SPINK5, HTR4, ADRB2 and IL12B.', 'Although no association was detected for any risk allele, three SPINK5 haplotypes (GGCT: p\u2009=\u20096\u2009×\u200910(-6); AATC: p\u2009=\u20090.0001; AGTT: p\u2009=\u20090.0001) and five ADRB2 haplotypes (AGGACC: p\u2009=\u20090.0014; AGGAAG: p\u2009=\u20090.0002; TGAGAG: p\u2009=\u20090.0001; AGGAAC: p\u2009=\u20090.0002; AAGGAG: p\u2009=\u20090.003) were associated with asthma. Notably, the AGTT SPINK5 haplotype exhibited a male gender-dependent association (p\u2009=\u20097.6\u2009×\u200910(-5)).'] Are sPINK5 and ADRB2 haplotypes risk factors for asthma in Mexican pediatric patients?