To open the regular season, the Lions hosted the Arizona Cardinals. The Cardinals took an early lead in the first quarter with an 82-yard interception return from Justin Bethel, followed by a 24-yard field goal from Phil Dawson. The Lions got on the board in the second quarter with a six-yard touchdown pass from Matthew Stafford to Marvin Jones Jr., and a 58-yard field goal from Matt Prater to make the score 10-9 in favor of Arizona at half-time. In the third quarter, the Cardinals added to their lead with a three-yard touchdown run from Kerwynn Williams, but the Lions responded with a seven-yard touchdown pass from Stafford to Theo Riddick. In the final quarter, the Lions took their first lead with a 10-yard touchdown pass from Stafford to Kenny Golladay. Stafford connected with Golladay again minutes later with a 45-yard touchdown pass, then Miles Killebrew returned an interception 35 yards for the Lions' final points. The Cardinals scored with a one-yard touchdown pass from Carson Palmer to J. J. Nelson, making the final score 35-23 in favor of Detroit. It was Matthew Stafford's 27th fourth quarter or overtime comeback since 2011, the most in the league.. Who threw more touchdown passes, Matthew Stafford or Carson Palmer?