Drug resistance refers to the susceptibility of a pathogen to a drug after repeated contact with the drug, which reduces or even disappears, resulting in a decrease or ineffectiveness of the drug. It is often used to refer to people. The large body of society, like humans, also produces large and small If the disease is not treated in a timely manner at the time of the first offense, and it is completely cured, drug resistance will also occur, causing some diseases to become persistent diseases. Which of the following best fits the definition of "resistance"? ['Hunan University found a sudden discomfort in the morning, and his family was rushed to the hospital for treatment, but nothing improved after taking any medicine. In the end, he had to go home and rest.', 'Pharaoh drank the cold medicine for three consecutive days after having a cold, but he did not get better. As a result, he only had one shot in the hospital.', 'Laws and regulations on illegal sewage are being formulated and promulgated almost every year, but some enterprises have illegally discharged sewage, and the incidents of excessive sewage discharge are still common and repeated bans.', 'Health-care slimming tea produced by a health-care product factory, which has been tested by the quality inspection department for carcinogens, shall be discontinued and closed in accordance with the law.']