['To evaluate the association of antral follicle count (AFC) with in\xa0vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) outcome in a large unselected cohort of patients covering the entire range of AFC.', 'Prospective observational study.', 'University-affiliated private infertility center.', '2,092 women undergoing 4,308 IVF-ICSI cycles.', 'AFC analyzed for associations with treatment outcome and statistically adjusted for repeated treatments and age.', 'Pregnancy rate, live-birth rate, and stimulation outcome parameters.', 'The AFC was log-normally distributed. Pregnancy rates and live-birth rates were positively associated with AFC in a log-linear way, leveling out above AFC ∼30. Treatment outcome was superior among women with polycystic ovaries, independent from ovulatory status. The findings were significant also after adjustment for age and number of oocytes retrieved.'] Are antral follicle counts strongly associated with live-birth rates after assisted reproduction , with superior treatment outcome in women with polycystic ovaries?