['The present study was undertaken to test whether methylene blue a soluble guanylate cyclase inhibitor, can initiate delivery in the mouse. The potential adverse effects of methylene blue on the fetal growth process were also investigated.', 'ICR (CD-I) mice were injected subcutaneously with Methylene blue at 0 (vehicle), 5, 30, 50, 60 or 85 mg/Kg on gestation days 15.5 and 16 (plug day = gestation day 0).', 'Methylene blue caused the mice to deliver before gestation day 18 (term gestation). This response was observed in 45%, 50% and 83% of animals receiving Methylene blue at 50, 60 or 85 mg/Kg, respectively (p < 0.05 vs. controls). In a dose-dependent fashion, Methylene blue induced a statistically significant (p < 0.05) derangement of the fetal growth process.'] Does the soluble guanylate cyclase inhibitor methylene blue evoke preterm delivery and fetal growth restriction in a mouse model?