The Giants' winning streak came to an end in San Francisco but they once again had the game in doubt into the final minutes. Field goals comprised the first half scoring, with Lawrence Tynes hitting two and the 49ers' David Akers recording three. The Giants took their only lead in the third quarter as Eli Manning found Mario Manningham for 13 yards to complete an 84-yard drive. The 49ers recorded two touchdowns on a pass to Vernon Davis and a run by Kendall Hunter, while Manning hit Hakeem Nicks for a 32-yard touchdown late in the game. New York received the ball late in the game and drove inside the 49ers' red zone, but Manning's last pass was deflected at the line of scrimmage to preserve the San Francisco win. Manning threw for 311 yards and two touchdowns but also recorded two interceptions, while Alex Smith threw for 242 and the touchdown pass to Davis. Brandon Jacobs rushed for 55 yards to lead the runners while Victor Cruz's 84 yards was tops for the receivers.. Who made the last play