['Blastocysts contain a large amount of fluid in the blastocoel, which may pose a risk for ice crystal formation during vitrification. This study aimed to evaluate the effectiveness of laser-induced artificial shrinkage of blastocoel before vitrification on clinical outcome.', 'Patients were divided into two groups: a control group with untreated, expanded blastocysts (n\u2009=\u2009115) and a study group with blastocoel artificially eliminated by a laser pulse prior to vitrification (n\u2009=\u2009309). Blastocyst survival, clinical pregnancy, and implantation rates were compared.', 'The survival rate was significantly higher in the study group compared with the control group (97.3 and 74.9\xa0%, respectively; p\u2009>\u20090.01). The clinical pregnancy and implantation rates of the study group were significantly higher (p\u2009<\u20090.01) than that of the control group (clinical pregnancy, 67.2 vs. 41.1\xa0%; implantation, 39.1 vs. 24.5\xa0%.'] Does artificial shrinkage of blastocoel using a laser pulse prior to vitrification improve clinical outcome?