['The purpose of this study was to investigate the relationship between the accessory pathway location and brain natriuretic peptide (BNP) level in patients with Wolff-Parkinson-White (WPW) syndrome.', 'We divided 102 WPW syndrome patients with normal left ventricular systolic function into four groups: those with manifest right (MR, n\u2009=\u200914), manifest septal (MS, n\u2009=\u200911), manifest left (ML, n\u2009=\u200930), and concealed (C, n\u2009=\u200947) accessory pathways. BNP level and electrophysiological properties, including difference in timing of the ventricular electrogram between the His bundle area and the distal coronary sinus area (His-CS delay), which indicate intraventricular dyssynchrony, were compared.', 'BNP levels (pg/dl) were higher in the MR and MS groups than in the ML and C groups (MR, 64\u2009±\u200958; MS, 55\u2009±\u200945; ML, 17\u2009±\u200915; C, 25\u2009±\u200921; P\u2009<\u20090.001). AV intervals (ms) were shorter in the MR and MS groups than in the ML and C groups (MR, 76\u2009±\u200916; MS, 83\u2009±\u20096; ML, 101\u2009±\u200919; C, 136\u2009±\u200920; P\u2009<\u20090.001). His-CS delay (ms) was longer in the MR group than in the other groups (MR, 50\u2009±\u200915; MS, 21\u2009±\u20097; ML, 23\u2009±\u200910; C, 19\u2009±\u20098; P\u2009<\u20090.001). The AV interval (P\u2009<\u20090.01) and the His-CS delay (P\u2009<\u20090.001) were negatively and positively correlated, respectively, with the BNP level.'] Does accessory pathway location affect brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome?