['To determine whether interferon alpha-2a, when utilised as adjuvant chemotherapy following ablation of condylomata acuminata (genital warts) by cryotherapy, is effective in the prevention of recurrences.', "Randomised, placebo-controlled, double-blind study. Statistical analysis was by 2-tailed Fisher's Exact Test.", '97 patients with recurrent condylomata acuminata.', '49 patients were treated with cryotherapy plus subcutaneously administered interferon alpha-2a, and 48 received cryotherapy plus placebo. Of these, 36 and 37 patients, respectively, completed the study and were evaluable.', 'Clinical eradication of condylomata for six months following adjuvant chemotherapy.', 'By completion of the adjuvant chemotherapy, 10 (28%) interferon recipients and 16 (43%) placebo recipients experienced recurrences. At six months follow-up, 25 (69%) interferon and 27 (73%) placebo recipients experienced recurrences. In the six months following interferon therapy, only 31% of interferon and 27% of placebo recipients remained free of recurrences (p = 0.99).'] Is recurrence of condylomata acuminata following cryotherapy prevented by systemically administered interferon?