['The higher probability of type 2 diabetes mellitus (T2DM) in the Uygur population is due to a greater waist:\u2009\u2009hip ratio and visceral fat. This study investigated DNA methylation of tumor necrosis factor-α (TNF), monocyte chemoattractant protein-1 (MCP1), and adiponectin (ADIPOQ) in visceral adipose tissue in T2DM.', 'Visceral adipose tissue was collected from Uygur individuals and divided into normal control (NC; n\u2009=\u200950), obese (Ob; n\u2009=\u200948), and T2DM (n\u2009=\u200926) groups. Expression of TNF, ADIPOQ, and MCP1 mRNA and DNA methylation status were quantified by reverse transcription-polymerase chain reaction and denaturing HPLC.', 'The respective methylation-positive rate for ADIPOQ increased gradually from the NC to Ob to T2DM groups (34.0\xa0%, 47.9\xa0%, and 65.4\u2009%; P\u2009<\xa00.05), decreased gradually for TNF (70.0\xa0%, 47.9\xa0%, and 26.9\u2009%; P\u2009<\xa00.01), and did not differ significantly for MCP1 (0\xa0%, 2.08\xa0%, and 0\xa0%). Compared with the NC group, ADIPOQ mRNA expression was significantly lower in the Ob and T2DM groups (median 0.7162 vs 0.4244 and 0.4093, respectively; P\u2009<\xa00.05), whereas TNF and MCP1 expression was significantly higher (median TNF expression: 0.0250 vs 0.1096 and 0.0734 respectively; median MCP1 expression 0.1588 vs 0.1937 and 0.1983, respectively; P\u2009<\xa00.05 for all). Expression of ADIPOQ and TNF was significantly lower in methylation-negative (median 0.7870 and 0.1988, respectively) than methylation-positive (median 0.2700 and 0.0542, respectively) groups (P\u2009<\xa00.01).'] Is dNA methylation of tumor necrosis factor-α , monocyte chemoattractant protein-1 , and adiponectin genes in visceral adipose tissue related to type 2 diabetes in the Xinjiang Uygur population?