['The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown.', 'To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis.', 'CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls.', 'CSF amounts of 78 kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p<0.01) and non-inflammatory controls (p<0.001) and in magnetic resonance imaging (MRI) inactive than in MRI active RRMS (p<0.00001).'] Are cerebrospinal fluid amounts of HLA-G in dimeric form strongly associated to patients with MRI inactive multiple sclerosis?