['Medline, Embase and the reference lists of identified articles were also scanned for relevant papers.', 'Only randomised controlled trials in English were considered.', 'Two reviewers extracted data independently and study quality was assessed using the Jadad score. Meta-analysis was conducted.', 'Four RCTs with a total of 183 patients were included. Intraoperative blood loss in the tranexamic acid group was statistically reduced (weighted mean difference [WMD] = -93.56, 95% CI = -132.59-54.52, P < .00001). No statistical difference was seen in the postoperative levels of haemoglobin and haematocrit (WMD = 0.50, 95% CIs = -0.43-1.43, P = .29 and WMD = 0.18, 95% CIs = -1.64-1.99, P = .85, respectively).'] Does tranexamic acid reduce intraoperative blood loss in orthognathic surgery?