['To investigate the possible association between the recently described interleukin 6 (IL-6) promoter polymorphisms at position -174, and susceptibility to ankylosing spondylitis (AS).', 'Ninety-two patients with AS, 157 healthy controls, and an additional group of 52 HLA-B27 positive unrelated individuals were included in this study. The -174 polymorphic site in the promoter region of IL-6 gene was typed by polymerase chain reaction-restriction fragment length polymorphism.', 'No statistically significant differences were observed when IL-6 promoter genotype and allele distribution between patients with AS and healthy controls were compared.'] Is interleukin 6 gene promoter polymorphism associated with ankylosing spondylitis?