Most people's diet contains excess fat. The fat in food is mainly in the form of triglycerides. In the digestive tract, fatty acids are hydrolyzed and released by lipase before they can be absorbed into the blood and re-synthesize triglycerides. If lipase is inhibited, this synthesis can be terminated. Some researchers have performed experiments on this. They divided female mice of equal weight into three groups, the first group fed freely and the second group fed a high-fat diet. The third group was fed a high-fat diet but added a "tea saponin" extracted from the tea. It was found that from the 5th week to the end of the 10th week, the weight of the second group of mice was It is significantly higher than the first group, but there is no significant difference between the third group and the first group. Therefore, the researchers have concluded that the "natural product" of tea saponin has the ability to inhibit lipase. Drinking tea does produce weight loss. Which of the following is true and most likely to question the researchers' above conclusions? ['Rats on a high-fat diet have approximately twice the weight of uterine fat than mice on a regular diet.', 'If tea saponin is added to a high-fat diet, its uterine fat is basically the same as that of a rat eating a regular diet.', 'The amount of tea saponin used in the experiment is too large. According to the same proportion, ordinary people need to drink at least five kilograms of dry tea a day.', 'The differences between mice and humans are still very large, and the conclusions of the mouse experiments have only a certain reference for humans.']