Rivers threw two touchdowns to Royal and spread the ball to multiple receivers to lead San Diego to a 22-10 victory over the Buffalo Bills. The Chargers' defense held the Bills to just 19 yards and forced a safety in their first four series in the fourth quarter, denying Buffalo their third 3-0 start since 1993. The Chargers led throughout the game after a 3-yard TD pass from Rivers to Royal with 9:45 left in the first quarter. They took control of the game after a 37-yard Novak field goal 21 seconds before the half, and a 5-yard TD catch by Royal to cap a 14-play, 80-yard drive to start the third quarter for a 20-3 lead, their largest of the game. San Diego held on for their third 2-1 start in five years. They did not have a first down in their final five drives after 20 in their first five. After losing running back Mathews to a sprained ankle the previous week, the Chargers' Danny Woodhead did not return after his first carry of the game &#8203;3&#160;1&#8260;2 minutes into the contest. Donald Brown filled in with 89 yards offense (62 rushing and 27 receiving). Rivers completed 18 of 25 passes for 256 yards, including two 49-yard catches by Floyd. Royal had four receptions for 42 yards, and backup tight end Ladarius Green finished with four catches for 64 yards. Novak extended his streak of consecutive successful field goal attempts to 23, passing Nate Kaeding for second in team history.. How many yards did Donald Brown rush for?