['To study the aqueous humor penetration of ligustrazine hydrochloride after ocular administration in rabbits.', 'Eighteen rabbits were randomly divided into 6 groups. The aqueous humor was collected at 5, 15, 30, 60, 120 and 180 minutes following topical administration of ligustrazine hydrochloride eye drops and the concentration of ligustrazine hydrochloride was determined by HPLC. Analytical column was Diamonsil C18 stainless steel column (250 mm x 4.6 mm, 5 microm); The mobile phase was methanol: water(62:38); Flow rate was 0.9 ml/min; The detection wavelength was 280 nm.', 'The concentrations of ligustrazine hydrochloride in aqueous humor were (15.785 +/- 2.988) microg/mL, (11.900 +/- 1.743) microg/mL, (8.286 +/- 1.182) microg/mL, (2.745 +/- 0.807) microg/mL, (0.379 +/- 0.091) microg/mL, (0.049 +/- 0.038) microg/mL, respectively, after a time interval of 5 min, 15 min, 30 min, 60 min, 120 min, 180 min. The maximum concentration was 15.785 microg/mL at 5 min, and then the concentration of ligustrazine hydrochloride gradually decreased and declined to a lower point at 180 min.'] Does [ Aqueous humor penetration of ligustrazine hydrochloride eye drop after topical administration in rabbit eyes ]?