['The study aimed to assess the role of CD151-integrin α3β1 (INGA3) complex as a potential prognostic indicator in OSCC and to examine whether mapping of its expression in the invasive front separately from that in the rest of the tumour would have an impact on the predictive value of the results. CD151/INGA3 profiles were compared with that of EGFR.', 'Protein distributions were analysed either in the whole tumour (W) or separately, (i) the main tumour mass (TU) and (ii) the invasive front (IF) in 83 OSCC samples using immunohistochemistry.'] Is loss of CD151/Tspan24 from the complex with integrin α3β1 in invasive front of the tumour a negative predictor of disease-free survival in oral squamous cell carcinoma?