['To report the association of a mosaic enhancement pattern on contrast-enhanced CT or MR imaging and hepatic sinusoidal dilatation (SD) with acute inflammatory conditions affecting extrahepatic organs.', 'From 2007 to 2012, patients with acute inflammatory diseases who underwent contrast-enhanced CT and/or MRI of the liver with a mosaic enhancement pattern were selected. Clinico-biological and other imaging features were collected at diagnosis and during follow-up.', "Sixteen patients were included (15 women, median age 27\xa0years; range 18-68). Five women (33\xa0%) were receiving oral contraceptives. Acute inflammatory diseases included pyelonephritis (n\u2009=\u200910), pancreatitis (n\u2009=\u20092), pneumonia (n\u2009=\u20091), septicemia (n\u2009=\u20091), active Crohn's disease (n\u2009=\u20091), and infectious colitis (n\u2009=\u20091). Median white blood cell count was 13,250 cells/μL (range 11,500-18,000 cells/μL) and CRP level 94\xa0mg/L (range 60-121\xa0mg/L). Mosaic enhancement pattern was present in the whole liver and was prominent in the subcapsular areas. Four patients underwent liver biopsy confirming SD. Eleven patients underwent follow-up imaging showing normalized aspect in 9/11 patients after a median of 2\xa0months."] Are acute extrahepatic infectious or inflammatory diseases a cause of transient mosaic pattern on CT and MR imaging related to sinusoidal dilatation of the liver?