The McNabb-less Eagles travelled to Indiana to take on the 9-1 Indianapolis Colts. Any chances of victory would be reliant upon a strong defensive showing, but the Colts stormed ahead behind three rushing touchdowns by rookie Joseph Addai in the first two quarters.  Philadelphia's new starting quarterback, Jeff Garcia, found L.J. Smith for a 1-yard touchdown to make it 21-7 in the second quarter. Adam Vinatieri booted a 44-yard kick before the end of the half for Indianapolis. Peyton Manning tossed an 11-yard touchdown pass to Reggie Wayne making it 31-7 Colts in the third quarter. The Eagles showed signs of life with touchdowns by Reggie Brown and Brian Westbrook to climb within ten with about ten minutes to play.  However, Addai scored his fourth touchdown of the game and a Garcia fumble led to a defensive touchdown for the Colts, making it 45-21 - a score representative of how overmatched the Eagles appeared all night. The Colts rushed for 237 yards on the Eagles' beleaguered defense. Westbrook had his third consecutive 100-yard game - the first Eagle to do that since Wilbert Montgomery 25 years ago. The loss drops the Eagles to under .500 for the first time all year.. How many points did the Colts win the game by?