The final breach is often considered to have arisen after the capture and sacking of Constantinople by the Fourth Crusade in 1204; the final break with Rome occurred circa 1450. The sacking of Church of Holy Wisdom and establishment of the Latin Empire as a seeming attempt to supplant the Orthodox Byzantine Empire in 1204 is viewed with some rancour to the present day. In 2004, Pope John Paul II extended a formal apology for the sacking of Constantinople in 1204, which was importantly also strongly condemned by the Pope at the time ; the apology was formally accepted by Patriarch Bartholomew of Constantinople. Many things that were stolen during this time —holy relics, riches, and many other items—were not returned and are still held in various European cities, particularly Venice. Reunion was attempted twice, at the 1274 Second Council of Lyon and the 1439 Council of Florence. The Council of Florence briefly reestablished communion between East and West, which lasted until after the fall of Constantinople in 1453. In each case, however, the councils were rejected by the Orthodox people as a whole, and the union of Florence also became very politically difficult after Constantinople came under Ottoman rule. Some local Eastern Churches have, however, renewed union with Rome in time since . Recent decades have seen a renewal of ecumenical spirit and dialogue between the Churches.. How many crusades were there before 1204?