['\u2002 Primary biliary cirrhosis (PBC) is a chronic cholestatic disease which is associated with hypercholesterolaemia. Further, cholestatic diseases are associated with deficiencies of anti-oxidant vitamins. Despite these associations PBC is not associated with an increase in cardiovascular mortality. The aim of this study is to assess if primary biliary cirrhosis is associated with oxidative stress, endothelial dysfunction and alteration of vascular compliance which is a surrogate marker for cardiovascular risk.', '\u2002 Fifty-one PBC patients and 34 control subjects were studied. Lipid soluble vitamins A, and E in addition to ascorbate and carotenoids were measured to assess anti-oxidant status. C-reactive protein, hydroperoxides and adhesion molecules sICAM-l/sVCAM-l were assessed as serological measures of endothelial function. Finally, measures of vascular compliance were assessed by applanation tonometer.', '\u2002 CRP, sICAM and sVCAM were all significantly higher in PBC patients (469.14 vs 207.13, P\u2003<\u20030.001; 768.12 vs 308.03,P\u2003<\u20030.001; 708.40 vs 461.31, P\u2003<\u20030.001) whilst anti-oxidant vitamin levels were lower in PBC patients, with ascorbate, vitamin E and vitamin A all significantly lower in PBC patients (39.91 vs 72.68, P\u2003<\u20030.001; 2.63 vs 3.14, P\u2003=\u20030.02; 1.08 vs 1.81, P\u2003<\u20030.001). Despite these findings PBC patients have a lower pulse wave velocity than control subjects (8.22\u2003m/s vs 8.78\u2003m/s, P\u2003=\u20030.022).'] Is primary biliary cirrhosis associated with oxidative stress and endothelial dysfunction but not increased cardiovascular risk?