['To investigate the association between the severity of sepsis and changes in sialylation of serum proteins we have conducted a single center pilot study.', 'Sialylation of transferrin (with enzyme-linked lectin assay-ELLA) and total serum proteins (with colorimetric assay) as well as serum iron and transferrin levels were measured in 27 patients with sepsis through the first eight days of the disease.', 'Total serum sialylation increased in the first two days, transferrin sialylation decreased, while serum iron and transferrin fell. Patients who developed severe sepsis had either a small or marked change in transferrin sialylation while in patients with mild sepsis sialylation decreased moderately.'] Does change of transferrin sialylation differ between mild sepsis and severe sepsis and septic shock?