['During the last few years, the association of mixed cryoglobulinemia with chronic viral infections has gained increasing interest. Chronic hepatitis C seems to play a major role. As alpha-interferon is an established therapy for chronic hepatitis C, it was also tried successfully in cryoglobulinemia type II, associated with chronic hepatitis C virus infection.', 'The course of 3 patients with cryoglobulinemia type II and chronic hepatitis C is presented.', 'Two patients received immunosuppressive therapy prior to alpha-interferon without success. In all cases, remission or improvement of the cryoglobulinemia was noticed with alpha-interferon, but none of the patients cleared the hepatitis C virus. Although the treatment was well tolerated, two patients developed neurologic resp. psychiatric side effects, probably due to alpha-interferon.'] Is [ Cryoglobulinemia in chronic hepatitis C. Improvement by alpha-interferon independent of virus elimination ]?