['Mounting evidence indicates that deregulation of apoptosis contributes to the development of human cancers. Bcl-2 family proteins regulate the intrinsic apoptosis pathway. The aim of this study was to explore the possibility that mutation of BH3 domain of proapoptotic Bcl-2 genes Bad, Bmf and Bcl-G might be involved in the development of urinary bladder cancer.', 'We analysed the BH3 domains of Bad, Bmf and Bcl-G genes for the detection of somatic mutations in 43 transitional cell carcinomas (TCCs) of the urinary bladder by a single strand conformation polymorphism assay in this study.', 'There was no somatic mutation of BH3 domains of Bad, Bmf and Bcl-G genes in the TCC samples.'] Is bH3 domain mutation of proapoptotic genes Bad , Bmf and Bcl-G rare in transitional cell carcinomas of the urinary bladder?