['To evaluate UBASH3A (rs11203203) as a predictor of persistent islet autoimmunity (IA) and type 1 diabetes (T1D).', 'The Diabetes Autoimmunity Study in the Young (DAISY) followed prospectively for development of persistent IA (autoantibodies to insulin, GAD65, IA-2, or ZnT8 on at least two consecutive exams) and diabetes 1715 non-Hispanic white children at increased genetic risk for T1D. The DAISY participants were genotyped for rs11202203 (UBASH3A).', 'UBASH3A allele A was associated with development of IA [hazard ratio (HR)\u2009=\u20091.46, 95%CI\u2009=\u20091.11-1.91, p\u2009=\u20090.007] and diabetes (HR\u2009=\u20091.84, 95%CI\u2009=\u20091.28-2.64, p\u2009=\u20090.001), controlling for presence of HLA-DR3/4,DQB1*0302 and having a first-degree relative (FDR) with T1D. The UBASH3A AA genotype conferred higher risk of persistent IA (12.7%) and diabetes (6.1%) by age 10 than for AG (7.7 and 3.1%, respectively) or GG (5.3 and 2.0%) genotype (p\u2009=\u20090.009 for IA, p\u2009=\u20090.0004 for diabetes). Among children with no family history of T1D, but HLA-DR3/4,DQB1*0302 and UBASH3A AA genotype, 35.9% developed IA and 50.6% developed diabetes by age 15.'] Is rs11203203 associated with type 1 diabetes risk in population pre-screened for high-risk HLA-DR , DQ genotypes?