['To study the change of inflammatory factors at different stages of colorectal cancer (CRC).', 'Thirty normal subjects, 30 patients with colorectal adenomatous polyps and 120 CRC patients at different stages were enrolled. IgG, IgM, and IgA levels, the inflammatory cytokines IL-2, 4, 6, 10, and 12 and the expression of TGF-β 1 and VEGF in the serum were analyzed by ELISA or immunoturbidimetry.', 'The serum concentrations of IL-12, TGF-β 1, and IL-6 in the CRC patients were statistically different compared with the normal and adenomatous polyps, and increased as the disease progressed (P<0.05). IL-6 reached the highest level in C phase of CRC.The serum concentrations of IL-2, IL-4, and IL-10 were significantly different among the groups. VEGF serum levels in CRC Phase A and Phase B compared with other groups were statistically different, but other serum concentrations had no significant difference (P>0.05). The serum level of IgG, IgM, and IgA in the 3 groups showed no significant difference (P>0.05).'] Do [ Inflammatory factors promote the development of colorectal cancer ]?