['Cardiovascular disease (CVD) is an important complication of chronic kidney disease (CKD) in children. However, it is not well known when and how cardiovascular alterations start.', 'This cross-sectional, controlled study consisted of 25 patients and 28 healthy controls. 24-h ambulatory blood pressure monitoring, aortic pulse wave velocity (aPWV), carotid intima-media thickness (cIMT) and carotid distensibility (distensibility coefficient and β stiffness index), and echocardiography were assessed to evaluate CVD. Routine biochemical parameters, fibroblast growth factor-23 (FGF23) and high sensitive C- reactive protein were measured to determine cardiovascular risk factors.', 'Hypertension was found in 12 patients (48\xa0%). Patients had higher FGF23 levels and aPWV-standard deviation score (SDS) as compared to the controls (p\xa0=\xa00.003 and p\xa0=\xa00.002, respectively). Aortic PWV-SDS was predicted by increased daytime systolic blood pressure load (β\xa0=\xa00.512, p\xa0=\xa00.009, R '] Do cardiovascular alterations do exist in children with stage-2 chronic kidney disease?