['Lipocalin 2 (Lcn2) is a multifunctional innate immune protein whose expression closely correlates with extent of intestinal inflammation. However, whether Lcn2 plays a role in the pathogenesis of gut inflammation is unknown. Herein, we investigated the extent to which Lcn2 regulates inflammation and gut bacterial dysbiosis in mouse models of IBD.', 'Lcn2 expression was monitored in murine colitis models and upon microbiota ablation/restoration. WT and ', 'Lcn2 expression was dramatically induced upon inflammation and was dependent upon presence of a gut microbiota and MyD88 signaling. Use of bone-marrow chimeric mice revealed non-immune cells are the major contributors of circulating Lcn2. '] Is microbiota-inducible Innate Immune , Siderophore Binding Protein Lipocalin 2 Critical for Intestinal Homeostasis?