['The functional Ser326Cys polymorphism in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in gastric cancer risk. However, the published findings are inconsistent. We therefore carried out a meta-analysis to investigate this relationship.', 'Nine published case-control studies, including 1180 gastric cancer cases and 2444 controls, were identified. Odds ratios and 95% confidence intervals were used to assess the strength of the association.', 'Overall, the hOGG1 Ser326Cys polymorphism was significantly associated with an increased risk of gastric cancer in a recessive model (Cys/Cys vs. Ser/Cys+Ser/Ser: odds ratio=1.31, 95% confidence interval: 1.03-1.67). In the stratified analysis, a significant association was also observed among Asian populations and hospital-based controls. However, when stratified by smoking status of gastric cancer patients, no statistically significant result was found.'] Is the functional Ser326Cys polymorphism in hOGG1 associated with gastric cancer risk : evidence from 1180 cases and 2444 controls?