['The antiviral activity of an established antibacterial CAP37 domain and its extracellular mechanism of action were investigated.', 'CAP37-derived peptides modified to assess the importance of disulfide bonds were evaluated in cytotoxicity and antiviral assays (direct time kill, dose dependency, and TOTO-1) for adenovirus (Ad) and herpes simplex virus type 1 (HSV-1).', 'Variable virus, adenovirus serotype-dependent, and dose-dependent inhibition were demonstrated without cytotoxicity. For peptide A (CAP37(20-44)), TOTO-1 dye uptake was demonstrated for Ad5 and HSV-1.'] Do cAP37-derived antimicrobial peptides have in vitro antiviral activity against adenovirus and herpes simplex virus type 1?