['There is a well-established link between migraine headaches and depression. However, it is unclear whether individuals with migraine experience a unique profile of depressive symptoms in comparison to individuals without migraine.', 'This question was addressed using data from the Baltimore cohort of the Epidemiologic Catchment Area Study. The cross-sectional association between migraine headaches and each depressive symptom was calculated using logistic regression, and symptom profiles among those with migraine headaches (n=249) and those without (n=1480) were compared using generalized estimating equations.', 'Migraine headaches were associated with increased odds of reporting seven of nine depressive symptom groups by a factor of roughly 2. However, when the symptom profiles were compared, individuals with migraine headaches did not differ in their profile of symptoms.'] Are migraine headaches associated with a unique depressive symptom profile : results from the Baltimore Epidemiologic Catchment Area Study?