['Among many neglected tropical diseases endemic in Honduras, soil-transmitted helminth (STH) infections are of particular importance. However, knowledge gaps remain in terms of risk factors involved in infection transmission. The aim of this study was to investigate risk factors associated with STH infections in schoolchildren living in rural Honduras.', 'A cross-sectional study was conducted among Honduran rural schoolchildren in 2011. Demographic, socio-economic, and epidemiological data were obtained through a standardized questionnaire and STH infections were determined by the Kato-Katz method. Logistic regression models accounting for school clustering were used to assess putative risk factors for infection.', 'A total of 320 children completed the study. Prevalences for any STH and for Ascaris lumbricoides, Trichuris trichiura and hookworms were: 72.5%, 30.3%, 66.9% and 15.9%, respectively. A number of risk factors were identified at the individual, household, and school level. Boys were at increased odds of infection with hookworms (OR 2.33, 95% CI\u2009=\u20091.23-4.42). Higher socio-economic status in the family had a protective effect against infections by A. lumbricoides (OR 0.80, 95% CI\u2009=\u20090.65-0.99) and T. trichiura (OR 0.77, 95% CI\u2009=\u20090.63-0.94).Low school hygiene conditions significantly increased the odds for ascariasis (OR 14.85, 95% CI\u2009=\u20097.29-30.24), trichuriasis (OR 7.32, 95% CI\u2009=\u20093.71-14.45), mixed infections (OR 9.02, 95% CI\u2009=\u20094.66-17.46), and ascariasis intensity of infection (OR 3.32, 95% CI\u2009=\u20091.05 -10.52).Children attending schools not providing deworming treatment or that had provided it only once a year were at increased odds of ascariasis (OR 10.40, 95% CI\u2009=\u20094.39-24.65), hookworm (OR 2.92, 95% CI\u2009=\u20091.09-7.85) and mixed infections (OR 10.57, 95% CI\u2009=\u20094.53-24.66).'] Are school hygiene and deworming key protective factors for reduced transmission of soil-transmitted helminths among schoolchildren in Honduras?