['Mouse fetuses with spontaneous myelomeningocele (MMC) were investigated, determining the various levels of dysraphism in soft tissue, spinal cord, and vertebrae. Morphology was correlated with hind limb function.', 'Viable curly tail/loop tail mouse fetuses underwent qualitative standardized ex utero examination of tail and hind limb sensitivity and motor response. Afterward, they were processed either for histology or skeletal preparation.', 'All animals displayed identical cranial levels of soft tissue and neural defects. The cranial opening of the vertebral defects were invariably located more cranially (range, 0.5-5 vertebrae; mean = 2.25). The caudal opening of soft/neural tissue and bony defects was invariably at the coccygeal base. The comparison of functional with morphological levels demonstrated that, in 52.5%, the level of the soft/neural tissue dysraphism and, in 47.5%, the level of the bony opening correlated with the neurologic deficit.'] Are the dysraphic levels of skin and vertebrae different in mouse fetuses and neonates with myelomeningocele?