Coming off their season-opening win over the defending Super Bowl champion Ravens, the Broncos traveled to East Rutherford, New Jersey, for an interconference duel against the New York Giants at MetLife Stadium. This was the third match-up between brothers Peyton Manning (Broncos) and Eli Manning (Giants), with Peyton Manning winning the previous two match-ups as a member of the Indianapolis Colts &#8212; 2006 and 2010. The Giants grabbed the lead midway through the first quarter, with a 36-yard field goal by placekicker Josh Brown. In the second quarter, a 20-yard touchdown run by running back Knowshon Moreno gave the Broncos the lead. Two field goals by Brown &#8212; from 24 and 41 yards &#8212; gave the Giants a 9-7 lead. The Broncos re-claimed the lead just before halftime, with placekicker Matt Prater nailing a 42-yard field goal. The Broncos increased their lead in the third quarter, with quarterback Peyton Manning connecting on a 2-yard touchdown pass to wide receiver Wes Welker. The Giants responded, with running back Brandon Jacobs rushing for a 1-yard touchdown to pull the Giants to within 17-16 with three minutes remaining in the third quarter. However, the Broncos would seize control of the game with 21 unanswered points, beginning with a 25-yard touchdown run by Moreno, followed in the fourth quarter by an 11-yard touchdown pass from Peyton Manning to tight end Julius Thomas, and return specialist Trindon Holliday returning a punt 81 yards for a touchdown. The Giants tried to rally, with quarterback Eli Manning throwing a 23-yard touchdown pass to running back Da'Rel Scott with four minutes remaining in the fourth quarter, but a 47-yard field goal by Prater put the game out of reach. Peyton Manning improved his head-to-head record against Eli Manning to 3-0. Offensive tackle Ryan Clady suffered a Lisfranc fracture in his foot late in the fourth quarter, and was placed on injured reserve three days later (September 18).. How many total yards did Knowshon Moreno have on touchdown runs?