The Anglo-Powhatan Wars were three wars fought between English settlers of the Virginia Colony, and Indians of the Powhatan Confederacy in the early seventeenth century. The First War started in 1610, and ended in a peace settlement in 1614. Another war between the two powers lasted from 1622 to 1626. The third war lasted from 1644 until 1646, and ended when Opechancanough was captured and killed. That war resulted in a boundary being defined between the Indians and English lands that could only be crossed for official business with a special pass. This situation would last until 1677 and the Treaty of Middle Plantation, which established Indian reservations following Bacon's Rebellion.. Which of the three Anglo-Powhatan Wars lasted the shortest?