['We investigate the influence that inguinal fat has on maximal quadriceps response to femoral nerve magnetic stimulation.', 'Vastus lateralis M-wave amplitude and quadriceps twitch peak torque were measured (i) in lean and overweight subjects and (ii) when slices of pig fat ranging from 2 to 18 mm in thickness were placed between the coil and the nerve.', 'In overweight group, the maximal response could not be elicited when intensity was ≤90% and ≤85% of maximal power for twitch torque and M-wave amplitude, respectively. The maximal response was obtained at 80% of maximal power in the lean group. Negative correlations between relative twitch torque changes and inguinal thickness were observed. Fat thickness altered quadriceps response at 14 mm and 8 mm in the lean and overweight groups, respectively.'] Does fat tissue alter quadriceps response to femoral nerve magnetic stimulation?