['Chronic bacterial prostatitis (CBP) is reported to be a common finding in men with acquired premature ejaculation (PE). The impact of different pathogens on PE development in chronic prostatitis patients is, however, unknown.', 'To assess a possible link between CBP caused by Chlamydia trachomatis (Ct) and PE.', 'A consecutive series of 317 patients with clinical and instrumental diagnosis of CBP due to Ct was enrolled (group A) and compared with data obtained from a control group of 639 patients with CBP caused by common uropathogen bacteria (group B). Prostatitis symptoms were investigated with the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), while the ejaculatory status of patients was assessed using the PE Diagnostic Tool (PEDT).', 'All participants were asked to complete the NIH-CPSI, the International Index of Erectile Function-15 erectile function domain (IIEF-15-EFD), the PEDT, and the Short Form (SF)-36 questionnaires.', 'Patient groups A and B had comparable scores of NIH-CPSI (P\u2009=\u20090.07), IPSS (P\u2009=\u20090.32), and IIEF-15-EFD (P\u2009=\u20090.33) tests. PE was assessed in 118 patients in group A (37.2%) and in 73 subjects in group B (11.5%). The two groups are different in terms of PE prevalence (P\u2009<\u20090.0002). Compared with group B, group A showed significantly higher scores of the PEDT test (11.3 [±2.6] vs. 4.5 [±2.9], P\u2009<\u20090.0001) and lower scores of the SF-36 tool (96.5 [±1.1] vs. 99.7 [±1.3], P\u2009<\u20090.0001). In our multivariate model assessment, being positive for a Ct infection marker was independently associated with the PEDT score even after adjusting for age, smoking habit, body mass index, and education level (adjusted odds ratio\u2009=\u20093.21; 95% confidence interval: 2.02-4.27; P\u2009<\u20090.003).'] Is chlamydia trachomatis infection related to premature ejaculation in chronic prostatitis patients : results from a cross-sectional study?