['Asian sand dust (ASD) originates from the arid and semiarid areas of China, and epidemiologic studies have shown that ASD exposure is associated with various allergic and respiratory symptoms. However, few studies have been performed to assess the relationship between skin inflammation and ASD exposure.', 'Twelve-week-old NC/Nga mice were divided into 6 groups (n\u2009=\u20098 for each group): hydrophilic petrolatum only (control); hydrophilic petrolatum plus ASD (ASD); hydrophilic petrolatum and heat inactivated-ASD (H-ASD); Dermatophagoides farinae extract (Df); Df and ASD (Df\u2009+\u2009ASD), and; Df and H-ASD (Df\u2009+\u2009H-ASD). The NC/Nga mice in each group were subjected to treatment twice a week for 4 weeks. We evaluated skin lesions by symptoms, pathologic changes, and serum IgE levels.', 'ASD alone did not induce atopic dermatitis (AD)-like skin symptoms. However, Df alone, Df\u2009+\u2009H-ASD and Df\u2009+\u2009ASD all induced AD-like symptoms, and dermatitis scores in the group of Df\u2009+\u2009ASD group were significantly greater than that of the Df group (P\u2009=\u20090.0011 at day 21; and P\u2009=\u20090.017 at day 28). Mean serum IgE was markedly increased in the Df and Df\u2009+\u2009ASD groups, compared to the ASD and control groups (P\u2009<\u20090.0001), and serum IgE levels in the Df\u2009+\u2009ASD group were significantly higher compared to the Df group (P\u2009=\u20090.003).'] Does asian sand dust aggregate cause atopic dermatitis-like symptoms in Nc/Nga mice?