['The objective of the current study was to evaluate the effect of obesity on pretreatment quality of life (QoL) in gynecologic oncology patients.', 'The authors analyzed collected data from an institution-wide cohort study of women with gynecologic cancers enrolled from August 2012 to June 2013. The Functional Assessment of Cancer Therapy-General, site-specific symptom scales, and the National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS) global mental and physical health tools were administered. Survey results were linked to clinical data abstracted from medical records (demographics and comorbid conditions). Bivariate tests and multivariate linear regression models were used to evaluate factors associated with QoL scores.', 'A total of 182 women with ovarian, uterine, cervical, and vulvar/vaginal cancers were identified; of these, 152 (84%) were assessed before surgery. Mean body mass index was 33.5 kg/m(2) and race included white (120 patients [79%]), black (22 patients [15%]), and other (10 patients [6.5%]). A total of 98 patients (64.5%) were obese (body mass index ≥30). On multivariate analysis, subscales for functional (17 vs 19; P\u2009=\u2009.04), emotional (16 vs 19; P\u2009=\u2009.008), and social (22 vs 24; P\u2009=\u2009.02) well-being as well as overall Functional Assessment of Cancer Therapy-General scores (77 vs 86; P\u2009=\u2009.002) and Patient-Reported Outcomes Measurement Information System global physical health scores (45 vs 49; P\u2009=\u2009.003) were found to be significantly lower in obese versus nonobese patients.'] Is obesity associated with worse quality of life in women with gynecologic malignancies : an opportunity to improve patient-centered outcomes?