['To report the successful treatment of primary orthostatic tremor in a 76-year-old man.', 'Primary orthostatic tremor is a rare condition, with few reports describing therapies. Established therapies had previously failed in our patient.', "Using an evidence-based evaluation of treatments via MEDLINE's GRATEFUL MED search engine, a therapeutic option was determined during the first consultation with the patient, and pramipexole therapy was initiated.", 'The therapy proved effective, and the patient had relief from his symptoms for the first time in 6 years.'] Is pramipexole a possible effective treatment for primary orthostatic tremor ( shaky leg syndrome )?