['OSA is associated with increased cancer incidence and mortality. Exosomes are vesicles secreted by most cells. They are released into the bloodstream and play a role in tumor progression and metastasis. We evaluated whether the chronic intermittent hypoxia (IH) that characterizes OSA leads to release of tumor-promoting exosomes in the circulation.', 'C57/B6 male mice were randomized to 6\xa0weeks of IH or room air (RA). A\xa0subgroup was injected with TC1 lung carcinoma cells in the left flank after 2\xa0weeks of IH. Exosomes from mouse plasma and from 10 adult human patients with OSA before and after treatment for 6\xa0weeks were cocultured with mouse TC1 and human adenocarcinoma cells lines. Malignant tumor properties such as proliferation, migration, invasion, and endothelial monolayer disruption were assessed, as was micro-RNA (miRNA), exosomal content, and transcriptomic effects of exosomes on TC1 cells in\xa0vitro to identify target genes.', 'Application of IH-induced exosomes from either IH-exposed tumor-bearing (IH+) or non-tumor-bearing (IH-) mice significantly promoted TC1 malignant properties. Similarly,\xa0before adherent treatment, exosomes from patients with OSA significantly enhanced proliferation and migration of human adenocarcinoma cells compared with after adherent treatment. Eleven distinct miRNAs emerged in IH-exposed mice, and their gene targets in TC1 cells were identified.'] Do tumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea?