The increase in the high-density fat protein content in the blood will increase the body's ability to prevent the absorption of excessive cholesterol, thereby reducing the cholesterol in the blood. Some people can significantly increase the high-concentration fat in the blood through regular physical exercise and weight loss Protein content. Based on the above discussion, what is the most appropriate conclusion that can be drawn? ['Some people lower cholesterol in their blood through regular physical exercise, then these people must be fat.', 'People who exercise regularly, especially fat people, have an increased risk of high cholesterol in their blood as they get older.', 'Physical exercise and weight loss are the most effective ways to lower high cholesterol in the blood.', 'Some people can lower cholesterol in their blood through regular physical exercise and weight loss.']