['Autosomal recessive hypotrichosis simplex (ARHS) presents with progressive hair loss mainly affecting the scalp area. In a small number of families, the condition has been associated with mutations in three distinct genes: DSG4, LIPH and LPAR6.', 'To identify the molecular basis of ARHS in a consanguineous family of Turkish extraction.', 'We used a combination of microsatellite marker screening and direct sequencing.', 'We identified a novel missense mutation (c.C587T) in the human LPAR6 gene, resulting in the amino acid substitution p.P196L. The mutation affects a highly conserved amino acid residue, and is predicted to disrupt signalling through the P2Y5 receptor.'] Does a novel mutation in LPAR6 cause autosomal recessive hypotrichosis of the scalp?