['The role of pleiotrophin and its receptors RPTPβ/ζ and Syndecan-3 during tumor metastasis remains unknown.', 'RPTPβ/ζ knockdown initiates EMT, promotes pleiotrophin-mediated migration and attachment through Syndecan-3 and induces in vivo metastasis.'] Does loss of receptor protein tyrosine phosphatase β/ζ ( RPTPβ/ζ ) promote prostate cancer metastasis?