['To assess whether partial meniscectomy is associated with increased risk of radiographic osteoarthritis (ROA) and worsening cartilage damage in the following year.', 'We studied 355 knees from the Osteoarthritis Initiative that developed ROA (Kellgren-Lawrence grade\u2009≥\u20092), which were matched with control knees. The MR images were assessed using the semi-quantitative MOAKS system. Conditional logistic regression was applied to estimate risk of incident ROA. Logistic regression was used to assess the risk of worsening cartilage damage in knees with partial meniscectomy that developed ROA.', 'In the group with incident ROA, 4.4\xa0% underwent partial meniscectomy during the year prior to the case-defining visit, compared with none of the knees that did not develop ROA. All (n\u2009=\u200931) knees that had partial meniscectomy and 58.9\xa0% (n\u2009=\u2009165) of the knees with prevalent meniscal damage developed ROA (OR\u2009=\u20092.51, 95\xa0% CI [1.73, 3.64]). In knees that developed ROA, partial meniscectomy was associated with an increased risk of worsening cartilage damage (OR\u2009=\u20094.51, 95\xa0% CI [1.53, 13.33]).'] Is partial meniscectomy associated with increased risk of incident radiographic osteoarthritis and worsening cartilage damage in the following year?