['It is unknown if cannabis recreates the negative symptoms of schizophrenia.', 'Healthy male volunteers (n\u2009=\u200922) completed two experimental sessions in which they received intravenous (IV) delta-9-tetrahydrocannabinol (THC) 2.5\u2009mg or placebo in a randomised counterbalanced order. Negative symptoms were rated using the self-reported community assessment of psychic experiences scale (CAPE). Sedation was rated using the mood-adjective check-list (UMACL). Plasma concentrations of THC were measured over the course of the study. Data were analysed by non-parametric tests.', 'Participants reported an increase in negative symptoms from baseline under THC but not placebo conditions (p\u2009<\u20090.001). Negative symptoms showed no relationship with self-rated sedation or plasma concentrations of THC.'] Does synthetic delta-9-tetrahydrocannabinol elicit schizophrenia-like negative symptoms which are distinct from sedation?