['Several studies have indicated that the carbon dioxide (CO(2)) pneumoperitoneum during laparoscopy plays a role in the pathogenesis of port-site metastases. An experimental animal study was performed to investigate the impact of various pneumoperitoneum pressures on peritoneal tumor growth.', 'In this study, 36 male WAG rats were randomized into three groups; two groups with different pneumoperitoneum pressures (16 mmHg and 4 mmHg) and one group of gasless controls. After a pneumoperitoneum of 0.5 x 10(6) ml was established, 531 tumor cells were injected intra-abdominally and the pneumoperitoneum was maintained for 60 min. Peritoneal tumor growth was assessed on day 11 at autopsy.', 'Peritoneal tumor growth in the 16-mmHg group was significantly greater than in the 4-mmHg group (p = 0.039) and the gasless group (p = 0.004).'] Is intraperitoneal tumor growth influenced by pressure of carbon dioxide pneumoperitoneum?