['Baroreflex control of the heart rate is impaired in hypertensive subjects and decreases with age. The decrease in cardiac baroreflex sensitivity (BRS) is often ascribed to decreased distension of the pressure-sensing arterial wall segments. However, alterations in the sensing and processing of neural signals may be involved as well.', 'Conventionally, both vessel wall stiffness and the sensing and neural processing of the baroreflex are incorporated in the measure of pressure-derived BRS. We introduce stretch-derived BRS, which only considers the sensing and neural components of the baroreflex.', 'To determine stretch-derived BRS in a non-invasive manner, we measured the spontaneously occurring low-frequency variations (range, 0.06-0.12 Hz) in the carotid artery diameter and the corresponding R-R interval fluctuations, and determined the associated transfer function. The stretch-derived BRS in a group of age-matched (age range, 25-72 years) normotensive (n = 20) and hypertensive (n = 21) subjects was compared.', 'In both subject groups the stretch-derived BRS decreased significantly with age. Moreover, the stretch-derived BRS of both groups was only different below 50 years of age.'] Does neural activity of the cardiac baroreflex decrease with age in normotensive and hypertensive subjects?