["An exaggerated decrease in diastolic blood pressure (DBP) upon raising the upper extremity is a sign of severe chronic aortic regurgitation (AR) (Mayne's sign). However, this finding was proposed prior to the widespread use of Doppler echocardiography.", 'To determine the relation between Doppler echo determined AR and changes in DBP.', 'We prospectively studied 30 controls without AR and 40 patients (69±15 years) with AR ranging from mild to severe and measured DBP before and during upper extremity raising.', 'The change in DBP was inversely correlated with age (r=-0.41, P<0.001) but not to the presence or severity of AR on Doppler echocardiography (r=-0.10, P=0.42).'] Is mayne 's sign mainly related to younger age and not to aortic regurgitation?