['To determine whether regular administration of beta 2-agonists could induce bronchial hyperreactivity in nonasthmatic volunteers.', 'A prospective, randomized, double-blind, placebo-controlled, crossover clinical trial of 2 weeks therapy with a 2-week washout period between each treatment period. Treatments were albuterol or matching placebo as 2 inhalations 4 times daily.', 'Ten healthy, nonsmoking women 27-37 years old.', 'General clinical research center of a tertiary care university hospital.', 'Baseline spirometry and methacholine bronchoprovocation studies were performed immediately prior to, 12 hours following, and 1 and 2 weeks following each treatment period.', 'No change was detected in either baseline spirometry or methacholine responsiveness.'] Do aerosolized beta 2-agonists induce bronchial hyperreactivity in healthy adults?