['Excisional biopsy is currently recommended for the analysis of lymphadenopathy suspicious for lymphoma. This study aims to evaluate the efficacy and safety of image-guided core needle biopsy (IGCNB) for the diagnosis of lymphoma using a standard protocol for tissue acquisition and analysis.', 'All IGCNBs from 2008 to 2014 performed under the study protocol were included in\xa0analysis. Demographics, pathology results, additional studies, and follow-up information were recorded.', 'Seventy-three IGCNBs were performed in 71 consecutive patients. Lymphoma was diagnosed in 37 patients (51%). All 37 patients (100%) were subtyped and treated based on IGCNB results. The remaining 36 IGCNBs in 34 patients did not have subsequent diagnosis of lymphoma in a mean follow-up of 15\xa0months (range, 0 to 54\xa0months). There were no complications.'] Is core needle biopsy a safe and accurate initial diagnostic procedure for suspected lymphoma?