['Generic drug discount programs (GDDPs) are an option to provide affordable prescription medication to low-income individuals. However, the factors that influence the use of GDDPs in low-income population are unknown.', 'To evaluate factors associated with utilization of generic a drug discount program in a low-income population.', 'A survey was administered to adult participants at health centers and community-based organizations in Houston, Texas, USA (n\xa0=\xa0525). Exploratory factor analysis was conducted to determine the construct validity of the survey instrument and to assess distinct factors associated with GDDP utilization. Descriptive statistics were used to summarize the distribution of patient socio-demographic characteristics and questionnaire responses. Multivariate logistic regression was used to compute adjusted odds ratios and to examine the strength of association with GDDP utilization after adjusting for participant socio-demographic features that were statistically significant at a priori level of P\xa0<\xa00.05.', 'In this study, 72% of respondents were aware of the GDDP, and 61% had utilized the GDDP. Participants were 4 times likely to use a GDDP when their physician (AOR: 4.0, 95% CI: 2.6-6.4, P\xa0<\xa00.001) or pharmacist (AOR: 4.0, 95% CI: 2.6-6.3, P\xa0<\xa00.001) talked to them about it. Participants indicated that the most important barriers to utilization of GDDPs were lack of awareness (44%), and lack of recommendation by a physician (19%).'] Do predictors of $ 4 generic prescription drug discount programs use in the low-income population?