['Recent studies have reported early atherosclerosis in patients with inflammatory bowel disease (IBD). In these patients, the chronic low-grade inflammation may predispose to vascular remodelling and arterial stiffening. We aimed at studying arterial stiffness in IBD patients.', 'Thirty-two IBD patients without cardiovascular risk factors and 32 matched controls were enrolled (age 19-49 years). SphygmoCor device (AtCor Medical, Sydney, Australia) was used to measure carotid-femoral and carotid-radial (muscular artery) pulse wave velocity (PWV), augmentation index and central blood pressure.', 'Carotid-femoral PWV was higher in IBD patients than in controls (6.6\u200a±\u200a1.4 vs. 6.0\u200a±\u200a0.8\u200am/s, respectively, P\u200a<\u200a0.05), as well as carotid-radial PWV (8.5\u200a±\u200a1.2 vs. 7.2\u200a±\u200a1.0\u200am/s, P\u200a<\u200a0.001). Central pulse pressure was higher in IBD than in controls (32\u200a±\u200a6 vs. 28\u200a±\u200a7\u200ammHg, P\u200a<\u200a0.05). Aging was an important determinant of carotid-femoral PWV in both groups and carotid-radial PWV only in IBD patients. In fully adjusted model performed in both groups of patients considered as a whole, age was positively associated with carotid-femoral PWV [R(2)\u200a=\u200a0.10; +0.05\u200am/s per 1 year of aging, 95% confidence interval (CI) 0.01-0.08\u200am/s, P\u200a<\u200a0.05], as well as IBD (R(2)\u200a=\u200a0.10; +0.72\u200am/s if IBD present, 95% CI 0.19-1.26\u200am/s, P\u200a<\u200a0.05). In IBD patients, carotid-radial PWV was positively associated with the disease duration (R(2)\u200a=\u200a0.20; +0.11\u200am/s per 1 year of aging, 95% CI 0.03-0.19\u200am/s, P\u200a<\u200a0.05).'] Is arterial stiffness increased in patients with inflammatory bowel disease?