["Oxidative stress represents a key event in the pathogenesis of Alzheimer's disease (AD). Low circulating concentrations of vitamin E, quantitatively the major lipophilic antioxidant in the brain, are frequently observed in AD patients, suggesting that supplementation with vitamin E may delay the development of AD.", 'To assess the value of therapeutic use of vitamin E in AD.', 'Search of the PubMed and Medline online libraries for relevant English-language publications between 1966 and 2007.'] Do an update on using vitamin E in Alzheimer 's disease?