['To investigate the effect of TNF-alpha on the endothelial function of human systemic arteries.', 'Omental arteries were obtained from healthy pregnant women undergoing Cesarean section and examined using isometric wire myography.', 'Incubation with TNF-alpha (1nM) alone did not alter bradykinin-mediated endothelium-dependent relaxation of arteries. However, TNF-alpha did attenuate nitric oxide- (NO) and prostacyclin-independent endothelial-mediated relaxation. Similarly, in vessels constricted with a high potassium solution (60 mM), which inhibits vasodilatation via endothelial-derived hyperpolarising factor (EDHF), TNF-alpha incubation also attenuated bradykinin-induced vasodilatation.'] Does tNF-alpha alter nitric oxide- and endothelium-derived hyperpolarizing factor-mediated vasodilatation in human omental arteries?