['Mutations of Crb1 gene cause irreversible and incurable visual impairment in humans. This study aims to use an LCA8-like mouse model to identify host-mediated responses that might interfere with survival, retinal integration and differentiation of grafted cells during neonatal cell therapy.', 'Mixed retinal donor cells (1\u2009~\u20092\u2009×\u200910', 'Transplanted retinal cells showed poor survival and attracted microglial cells, but CSPG was not greatly induced. Retinas of the LCA8 model hosts underwent significant cellular rearrangement, including rosette formation and apical displacement of inner retinal cells.'] Does neonatal disease environment limit the efficacy of retinal transplantation in the LCA8 mouse model?