["Altered brain connectivity is implicated in the development and clinical burden of schizophrenia. Relative to matched controls, schizophrenia patients show (1) a global and regional reduction in the integrity of the brain's white matter (WM), assessed using diffusion tensor imaging (DTI) fractional anisotropy (FA), and (2) accelerated age-related decline in FA values. In the largest mega-analysis to date, we tested if differences in the trajectories of WM tract development influenced patient-control differences in FA. We also assessed if specific tracts showed exacerbated decline with aging.", 'Three cohorts of schizophrenia patients (total n = 177) and controls (total n = 249; age\u2009=\u200918-61 years) were ascertained with three 3T Siemens MRI scanners. Whole-brain and regional FA values were extracted using ENIGMA-DTI protocols. Statistics were evaluated using mega- and meta-analyses to detect effects of diagnosis and age-by-diagnosis interactions.', 'In mega-analysis of whole-brain averaged FA, schizophrenia patients had lower FA (P\u2009=\u200910'] Does heterochronicity of white matter development and aging explain regional patient control differences in schizophrenia?