Ancient civilizations generally formed inland areas along the mid-latitude rivers, suitable climate and fertile soil conditions are more suitable for human activities. With the development of science and technology, these factors have gradually been weakened, and human activities have shifted from inland to coastal areas. The economic gradient of modern coastal to inland appeared. Comparing the environmental differences between ancient civilizations and modern coastal civilizations, the core of which is the change in the related environmental requirements of transportation and accessibility. However, the development of highway and railway traffic on the road And brought new opportunities to the development of the inner roads. From this text, it can be concluded that:. ['Civilization has different requirements for environmental factors in different periods.', 'Environmental factors are essential for the formation of civilization in a certain period.', 'The development of science and technology can change the requirements of civilization on environmental factors in a certain period.', 'Transport can bring new opportunities to the development of a region at different times.']