['Cardiorespiratory fitness (CRF) and diet have been involved as significant factors towards the prevention of cardio-metabolic diseases. This study aimed to assess the impact of the combined associations of CRF and adherence to the Southern European Atlantic Diet (SEADiet) on the clustering of metabolic risk factors in adolescents.', 'A cross-sectional school-based study was conducted on 468 adolescents aged 15-18, from the Azorean Islands, Portugal. We measured fasting glucose, insulin, total cholesterol (TC), HDL-cholesterol, triglycerides, systolic blood pressure, waits circumference and height. HOMA, TC/HDL-C ratio and waist-to-height ratio were calculated. For each of these variables, a Z-score was computed by age and sex. A metabolic risk score (MRS) was constructed by summing the Z scores of all individual risk factors. High risk was considered when the individual had ≥ 1 SD of this score. CRF was measured with the 20 m-Shuttle-Run-Test. Adherence to SEADiet was assessed with a semi-quantitative food frequency questionnaire. Logistic regression showed that, after adjusting for potential confounders, unfit adolescents with low adherence to SEADiet had the highest odds of having MRS (OR = 9.4; 95%CI:2.6-33.3) followed by the unfit ones with high adherence to the SEADiet (OR = 6.6; 95% CI: 1.9-22.5) when compared to those who were fit and had higher adherence to SEADiet.'] Is cardiorespiratory fitness negatively associated with metabolic risk factors independently of the adherence to a healthy dietary pattern?