['Studies have shown that caregivers report impaired quality of life (QOL). This study investigated how caregiving motives predict long-term spirituality and QOL among cancer caregivers and the role of gender in these associations.', "Caregiving motives of family members (n\u2009=\u2009369) were measured 2\xa0years after their relative's cancer diagnosis (T1), and both spirituality and QOL (mental and physical health) were measured at 5\xa0years postdiagnosis (T2).", 'Structural equation modeling was used to test spirituality dimensions as potential mediators of links from caregiving motives to QOL. Among male caregivers, autonomous caregiving motives at T1 related to better mental health at T2, apparently because these motives led caregivers to find greater peace and meaning in life at T2.'] Does caregiving Motivation predict Long-Term Spirituality and Quality of Life of the Caregivers?