Wirth: All efforts to identify a gene responsible for predisposing people to manic-depression have failed. In fact, nearly all researchers now agree that there is no "manic-depression gene. " Ttherefore, if these researchers are right, any claim that some people are genetically predisposed to manic-depression is simply false. Chang: I do not dispute your evidence, but I take issue with your conclusion. Many of the researchers you refer to have found evidence that a set of several genes is involved and that complex interactions among these genes produce a predisposition to manic-depression. The point at issue between Wirth and Chang is whether ['nearly all researchers now agree that there is no manic-depression gene', 'it is likely that researchers will ever be able to find a single gene that predisposes people to manic-depression', 'efforts to identify a gene or set of several genes responsible for predisposing people to manic-depression have all failed', 'current research supports the claim that no one is genetically predisposed to manic-depression']