['Studies have indicated that working under sleep deprivation conditions results in deficits in performance on various tasks. Few studies, however, have attempted to find a measure for predicting performance changes under sleep deprivation conditions. The current study examined whether oculomotor measures could predict changes in performance under non-sleep deprivation and acute short-term sleep deprivation conditions.', 'Oculomotor measures and performance were examined during five testing sessions in each study. In the non-sleep deprivation study (N = 23) the testing sessions took place during 2 consecutive days. The sleep deprivation study (N = 26) took place in an 18-h sustained operations period during the night of sleep deprivation.', 'Under non-sleep deprivation conditions, pupil diameter significantly predicted performance on grammatical reasoning (B = 0.360) and constriction latency significantly predicted performance on combined tasks (B = 0.182). Under sleep deprivation conditions, diameter, constriction latency, and saccadic velocity significantly predicted performance on a psychomotor vigilance task (B = -21.002, B = -23.126, B = -18.028, respectively). Overall, oculomotor measures better predicted performance changes under sleep deprivation conditions and better predicted performance decrements on vigilance-based tasks than cognitive tasks under acute sleep deprivation conditions.'] Does oculomotor measure as predictors of performance during sleep deprivation?