['Notch3 is expressed in myogenic precursors, but its function is not well known.', 'Notch3 represses the activity of Mef2c and is in turn inhibited by the microRNAs-1 and -206.'] Are notch3 and Mef2c proteins mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts?