['The aim of this study was to explore the clinical significance of miR-145-5p expression in gastric cancer (GC).', 'Expression of miR-145-5p was evaluated by qRT- PCR in tumor and normal gastric tissues in 145 GC patients. The correlation between the miR-145-5p expression and clinicopathological parameters was investigated. Finally, the survival was assessed by the Kaplan-Meier method and proportional hazards model.', 'Expression levels of miR-145-5p in GC tissues were significantly lower than those in adjacent normal tissues (p < 0.001). MiR-145-5p expression was significantly associated with lymph node metastasis, metastasis stage, and distant metastasis (all p < 0.05). Furthermore, Patients with low miR-145-5p expression had poorer overall survival time than those with high miR-145-5p expression (p = 0.014). Moreover, univariate and multivariate Cox analysis showed that miR-145-5p was an independent prognostic indicator for OS (p = 0.011).'] Does downregulation of miR-145-5p correlate with poor prognosis in gastric cancer?