Australian box jellyfish is one of the most toxic animals in the world, and its toxins can cause skin necrosis of humans with severe pain, and also invade the human heart, causing people to die due to cardiac arrest in a short time. Only box-shaped jellyfish carry enough venom to cause 60 deaths, and there is currently no specific drug for its venom. Recently, researchers discovered through genome-wide screening that a protein called ATP2B1 in human cells is box-shaped Jellyfish venom is necessary for its toxicity, and researchers believe that lowering cholesterol through targeted therapies can combat box venom. Which of the following can be used as a prerequisite for the above argument? ['Targeted therapy is a safe and reliable method.', 'ATP2B1 protein needs cholesterol to function.', 'No side effects on the body after lowering cholesterol.', 'Targeted therapies have been developed to lower cholesterol.']