['The management of diabetic neuropathy is still a challenge for physicians. The aim of this study was to assess the efficacy of a new combination of alpha lipoic acid and superoxide dismutase for the treatment of diabetic neuropathy.', 'The setting of this study was ambulatory (outpatient) care. A prospective, non-randomized, open-label study was conducted in 50 patients with diabetes mellitus and with a deficit in both motor and sensory nerve conduction. Treatment was with a new combination of alpha lipoic acid and superoxide dismutase (ALA600SOD®) for 4 months. Electroneurographic parameters and perceived pain were assessed at baseline and after treatment.', 'After 4 months of treatment, patients significantly (p\u2009<\u20090.001) improved their electroneurographic parameters and their perception of pain. Best improvements were observed in sensory nerve conduction.'] Does combination of alpha lipoic acid and superoxide dismutase lead to physiological and symptomatic improvements in diabetic neuropathy?