['To compare high-definition (HD) spectral-domain optical coherence tomography [SD-OCT] (Cirrus HD-OCT; Carl Zeiss, Dublin, California, USA) with time-domain optical coherence tomography [TD-OCT] (Stratus version 4; Carl Zeiss) for imaging macula in patients of uveitis.', 'Interventional case series.', 'Thirty consecutive patients (51 eyes) with uveitis of various causes with vitreous haze of 1+ or worse were treated in an institutional setting. All patients had their vitreous haze graded and OCT scans both on TD-OCT (Stratus) and SD-OCT (Cirrus). Information obtained from Cirrus OCT scans was compared with that obtained from Stratus OCT scans.', 'Overall, for all grades of media clarity, the macula was interpreted as normal in 30 eyes (58.8%) on Stratus OCT and 26 eyes (50.9%) on Cirrus OCT and abnormal in 15 eyes (29.4%) on Stratus OCT and 24 eyes (47.0%) on Cirrus OCT, whereas poor scan quality deterred any interpretation in six eyes (10.0%) on Stratus OCT and only in one eye (1.8%) on Cirrus OCT. Additional information on Cirrus OCT could be obtained in nine (21.9%) of 41 eyes with grade 1+ vitreous haze, six (75%) of eight eyes with grade 2+ vitreous haze, and one eye (50%) with vitreous haze of 3+.'] Is spectral-domain Cirrus high-definition optical coherence tomography better than time-domain Stratus optical coherence tomography for evaluation of macular pathologic features in uveitis?