['We aimed to determine whether measuring the hyperacute lipid profile helps to start a cholesterol-lowering therapy soon after an ischemic stroke.', '72 ischemic stroke patients underwent lipid determinations at three times (hyperacute phase or arrival, second day and the third month).', 'Total cholesterol, cLDL, cHDL and triglyceride mean values were significantly higher (p < 0.05) at arrival compared to the second day (212 vs 189; 131 vs 120; 52 vs 44 and 132 vs 115, respectively). In the third month, mean values were similar to those of the hyperacute phase (197, 131, 48 and 143, respectively). Considering the updated cholesterol management guidelines, we should treat 55% of patients diagnosed at the hyperacute phase but only 37% of patients diagnosed at the second day.'] Does [ Lipid profile in the hyperacute phase of ischemic stroke allow to decide cholesterol-lowering therapy ]?