['Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression.', 'The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis.', 'Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom(®) MassArray™ iPLEX Gold platform.', 'We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10(-4) ; rs2069778, genotypic P = 7·86 × 10(-4)) region.'] Does a systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveal an association with IL2/IL21?