['A patient-reported outcome (PRO) is a subjective report that comes from a patient without interpretation by a clinician. Because of the increasingly significant role of PROs in the development and evaluation of new medicines, the US Food and Drug Administration (FDA) issued a formal guidance to describe how PRO instruments will be reviewed and evaluated with respect to claims in approved medical product labeling. Meanwhile, PROs continue to appear in oncology clinical trials more frequently; however, it is unclear how payers and policymakers can use PRO data in the context of decision-making for cancer treatments.', 'The objective of this article is to discuss the challenges and opportunities of incorporating oncology-related PRO data into payer decision-making.'] Are patient-reported outcomes changing the landscape in oncology care : challenges and opportunities for payers?