Hoping to rebound from their first loss of the season, the Broncos returned home for an AFC West divisional rematch with the Kansas City Chiefs. After Peyton Manning became the NFL's all-time leader in regular season passing yardage, the game turned sour for the Broncos. Following a Manning interception, the Chiefs capitalized, with a 4-yard touchdown run by running back Charcandrick West. The Broncos' offense went three-and-out on their next two possessions, and the Chiefs increased their lead to 10-0, with a 48-yard field goal by placekicker Cairo Santos. The Chiefs increased their lead to 19-0 at halftime, with three more field goals by Santos &#8212; from 49, 34 and 33 yards out. By halftime, Manning had thrown three interceptions and the Broncos' offense had earned only one first down. The Broncos went three-and-out on their first possession of the second half, and a 50-yarder field goal by Santos increased the Chiefs' lead to 22-0. After Manning threw his fourth interception of the game on the Broncos' next possession, he was pulled and replaced by backup quarterback Brock Osweiler for the remainder of the game. Osweiler drove the Broncos' into the red zone early in the fourth quarter, but was intercepted by Chiefs' safety Eric Berry. Two plays later, the Chiefs increased their lead to 29-0, when quarterback Alex Smith connected with West on an 80-yard touchdown pass. The Broncos' finally got on the scoreboard with 5:31 remaining in the game, with running back Ronnie Hillman rushing for a 1-yard touchdown (two-point conversion attempt unsuccessful), followed by a 7-yard touchdown pass from Osweiler to wide receiver Andre Caldwell, but the Chiefs' lead was too much for the Broncos to overcome. Peyton Manning finished the day with the first 0.0 passer rating of his career.. How many interceptions did Manning throw during the game?