['Both multiple sclerosis (MS) susceptibility and MS clinical phenotype are in part genetically determined. [Alpha]B-crystallin is a candidate autoantigen in MS, and there are three polymorphisms in the promoter region of the encoding gene (CRYAB): at positions -C249G, -C650G, and -A652G.', 'These polymorphisms were studied in sporadic cases of MS, assessing disease susceptibility, clinical phenotype, and MRI appearance.', 'The CRYAB polymorphisms influenced susceptibility as well as disease expression in MS.'] Does [ Alpha ] B-crystallin genotype have impact on the multiple sclerosis phenotype?