['Red blood cell transfusion is done primarily as a means to improve oxygen delivery (DO₂). Current transfusion guidelines are based solely on hemoglobin levels, regardless of actual DO₂ need. As central venous oxygen saturation (ScvO₂) may reflect imbalances in DO₂ and consumption (VO₂) the aim of this study was to investigate the value of ScvO₂ as an indicator of oxygen balance in isovolemic anemia.', 'After splenectomy, anesthetized Vietnamese mini pigs (n\u2009=\u200913, weight range: 18-30\u2009kg) underwent controlled bleeding in five stages (T₀-T₅). During each stage approximately 10% of the estimated starting total blood volume was removed and immediately replaced with an equal volume of colloid. Hemodynamic measurements and blood gas analysis were then performed.', 'Each stage of bleeding resulted in a significant fall in hemoglobin, T₀ : 125 (113-134) to T(5) : 49 (43-55) g/l [T₀ : 7.7 (6.9-8.2) to T₅ : 3.0 (2.6-3.4) mmol/l]. The O₂-extraction (VO₂/DO₂) increased significantly only from T₃ : 35 (21-40) %, P\u2009<\u20090.05. The change of ScvO₂ showed a similar pattern and dropped below the physiological threshold of 70% at T₄ : 68 (61-76) %. At this point, hemoglobin was below the recommended transfusion trigger value, 59 (53-67) g/l [3.6 (3.3-4.1) mmol/l]. There was a strong significant association between ScvO₂<\u200970%) and VO₂/DO₂ >\u200930%): r\u2009=\u2009-0.71, r² \u2009=\u20090.50, P\u2009<\u20090.001.'] Is central venous oxygen saturation a good indicator of altered oxygen balance in isovolemic anemia?