['It is well known that animals show a stress response when confronted with a novel environment. The aim of the this study was to investigate whether humans show a similar response by studying the reaction to a travel-related transitory change of residence.', 'Forty-eight individuals (32 women, 16 men, age 40-83\u2009years) traveling to a health resort approximately 120\u2009km from their home town participated in the study. Individuals monitored their blood pressure (BP) twice a day 3\u2009weeks before (baseline) and during the stay and filled out a diary stating their mood and sleep. The change of the variables relative to baseline on the day before departure, the travel day, and the day after arrival as well as 5\u2009days after arrival were determined.', 'Systolic and diastolic BPs were increased on the day before travel and diastolic BP remained increased on the travel day and the day after arrival. Sleep was poorer during the first night at the new residence. All three variables had returned to baseline level 5\u2009days into the stay. Mood was not affected by the change of residence.'] Does travel-related change of residence lead to a transitory stress reaction in humans?