['The purpose of this study was to determine if increased intraluminal pressure is the damaging factor which reduces flow mediated dilation (FMD) in young, healthy subjects following resistance exercise to maximal exertion.', 'Attenuating the rise in brachial artery pressure during weight lifting by placing a blood pressure cuff on the upper arm prevents post-exercise impairment of brachial artery FMD in sedentary individuals.', 'Nine sedentary individuals who exercise ≤1 time/week and six exercise-trained individuals who exercise ≥3 times/week performed leg press exercise to maximal exertion on two separate occasions. During one visit a blood pressure cuff, proximal to the site of brachial artery measurement, was inflated to 100 mmHg to protect the distal vasculature from the rise in intraluminal pressure which occurs during resistance exercise. Brachial artery FMD was determined using ultrasonography before and 30 minutes after weight lifting.', 'Without the protective cuff, brachial artery FMD in sedentary individuals was reduced after weight lifting (9.0 ± 1.2% pre-lift vs. 6.6 ± 0.8% post-lift; p=0.005) while in exercise-trained individuals FMD was unchanged (7.4 ± 0.7% pre-lift vs. 8.0 ± 0.9% post-lift; p=0.543). With the protective cuff, FMD no longer decreased, but rather increased in sedentary individuals (8.7 ± 1.2% pre-lift vs. 10.5 ± 1.0% post-lift, p=0.025). An increase in FMD was also seen in exercise-trained subjects when the cuff was present (6.6 ±0.7% pre-lift vs. 10.9 ±1.5% post-lift, p<0.001).'] Does hypertension during Weight Lifting reduce Flow-Mediated Dilation in Nonathletes?