['To physiologically test the durability of a sutureless aortic stent-graft based on nitinol bonded to polyhedral oligomeric silsesquioxane (POSS) and poly(carbonate-urea) urethane (PCU) for 10 years according to Food and Drug Administration guidelines.', 'Aortic stent-grafts (n\u200a=\u200a4) were tested in 37°C distilled water using simulated in vivo hydrodynamic pulse loading. After 400 million cycles, surface topography was assessed by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. Dynamic compliance was measured using a pulsatile flow phantom. Mechanical and elastic properties were determined by stress-strain studies and elastic deformation tests. Dynamic scanning calorimetry (DSC) and thermomechanical analysis (TMA) were used to assess thermal resistance. Comparison was made with a zero-cycled control.', 'All stent-grafts successfully completed accelerated pulsatile fatigue at 94±14-mmHg pulse pressure. SEM images confirmed uniform surface topography without any fractures. FTIR showed increased intensity of -NHCO- bonds, but there was no significant sign of biodegradation. Tensile stress of fatigue-tested polymer compared favorably with the zero-cycled control at 50% to 500% strain (p\u200a=\u200a0.69). At a mean pressure range of 60 to 120 mmHg, overall compliance of the fatigue-tested grafts was 3.48±1.27%mmHg(-1)×10(-2) with no significant difference compared to control (3.26±0.65%mmHg(-1)×10(-2); p\u200a=\u200a0.47). DSC and TMA showed comparable thermotropic transition.'] Is a sutureless aortic stent-graft based on a nitinol scaffold bonded to a compliant nanocomposite polymer durable for 10 years in a simulated in vitro model?