['The presence of intraparenchymal hyperattenuations (IPH) on flat-panel computed tomography (FP-CT) after endovascular recanalization in stroke patients is a\xa0common phenomenon. They are thought to occur in ischemic areas with breakdown of the blood-brain barrier but previous studies that investigated a\xa0mutual interaction are scarce. We aimed to assess the relationship of IPH localization with prethrombectomy diffusion-weighted imaging (DWI) lesions.', 'This retrospective multicenter study included 27 acute stroke patients who underwent DWI prior to FP-CT following mechanical thrombectomy. After software-based coregistration of DWI and FP-CT, lesion volumetry was conducted and overlapping was analyzed.', 'Two different patterns were observed: IPH corresponding to the DWI lesion and IPH exceeding the DWI lesion. The latter showed demarcated infarction of DWI exceeding IPH at 24\xa0h. No major hemorrhage following IPH was observed. Most IPH were manifested within the basal ganglia and insular cortex.'] Are intraparenchymal Hyperattenuations on Flat-Panel CT Directly After Mechanical Thrombectomy Restricted to the Initial Infarct Core on Diffusion-Weighted Imaging?