['Catheter hub decontamination requires a thorough scrub and compliance varies. This study evaluates the effectiveness of a disinfection cap with 70% alcohol in preventing contamination/infection.', 'A 3-phased, multifacility, quasi-experimental study of adult patients with central lines divided into P1 (baseline), when the standard scrub was used; P2, when the cap was used on all central lines; and P3, when standard disinfection was reinstituted. House-wide central-line associated bloodstream infection (CLABSI) rates are reported with catheter-associated urinary tract infections (CAUTI) as\xa0a control measure. Adults with peripherally inserted central catheters inserted during hospitalization having 5+ consecutive line-days gave consent and were enrolled, and 1.5 mL of blood was withdrawn from each lumen not in use and quantitatively cultured.', 'Contamination was 12.7% (32/252) during P1; 5.5% (20/364) in P2 (P\xa0=\xa0.002), and 12.0% (22/183; P\xa0=\xa00.88 vs P1 and P\xa0=\xa0.01 vs P2) in P3 (P\xa0=\xa0.001 vs P2). The median colony-forming units per milliliter was 4 for P1, 1 for P2 (P\xa0=\xa0.009), and 2 for P3 (P\xa0=\xa0.05 vs P2). CLABSI rates declined from 1.43 per 1,000 line-days (16/11,154) to 0.69 (13/18,972) in P2 (P\xa0=\xa0.04) and increased to 1.31 (7/5,354) in P3. CAUTI rates remained stable between P1 and P2 (1.42 and 1.41, respectively, P\xa0=\xa0.90) but declined in P3 (1.04, P\xa0=\xa0.03 vs P1 and P2).'] Does continuous passive disinfection of catheter hubs prevent contamination and bloodstream infection?