['Authors examined the effect of chronic exposure to anticholinergics in a cohort of Alzheimer disease (AD) patients.', 'All patients were examined annually with standard neuropsychologic tests and received the cholinesterase inhibitor donepezil hydrochloride at a dose of 10 mg/day. The study population (N=69) was divided into two groups: those receiving one or more concomitant medications with significant anticholinergic properties (N=16) and those receiving no concomitant medications with anticholinergic properties (N=53).', 'At 2 years, MMSE scores were significantly worse for patients receiving anticholinergic medications than for those not on anticholinergics.'] Does chronic exposure to anticholinergic medications adversely affect the course of Alzheimer disease?