['Chronic pancreatitis (CP) may be difficult to diagnose in early stages. We aimed to measure pancreatic juice (PJ) prostaglandin E2 (PGE2) concentrations to determine whether they are elevated in CP and improve diagnosis of early disease.', 'We measured PJ PGE2 in 10 patients with established CP, 25 patients who met criteria for "minimal change" chronic pancreatitis (MCCP), and 10 normal control participants.', 'Median PJ PGE2 was elevated in CP (307\u2009pg/ml, IQR (249-362)) and MCCP (568\u2009pg/ml, (418-854)) compared with normal controls (104\u2009pg/ml, (68-206)) (P≤ 0.001). Area under receiving operator curve (AUROC) for diagnosis of CP and MCCP was 0.9 and 0.62, respectively, for PJ bicarbonate concentration alone; AUROC was 1.0 and 0.94 for the combination of PJ bicarbonate and PGE2 concentrations.'] Are pancreatic juice prostaglandin e2 concentrations elevated in chronic pancreatitis and improve detection of early disease?