['This study assessed prevalence and correlates of anergy among a cohort of drug users in communities in the San Juan metropolitan area.', 'In all, 719 drug injectors and crack users were recruited in neighbourhoods in the San Juan metropolitan area following a stratified cluster design of 30 copping areas (places where drugs are sold).', 'Slightly more than one-third of the total proportion of participants, 34.2%, were HIV positive and 30.3% anergic. Subjects with a history of incarceration, the HIV positive, and those reporting chronic illness were more likely to be anergic than those subjects without these characteristics.'] Does prevalence and correlate of anergy among drug users in Puerto Rico?