Spice What Are Synthetic Cannabinoids (“Spice” or K2/K3″)? synthetic marijuana National Institute on Drug Abuse: Synthetic Marijuana National Institute on Drug Abuse Synthetic cannabinoids K2 and Spice Spice Synthetic Cannabinoids (K2/Spice) Spice Spice National Institute on Drug Abuse - Synthetic Cannabinoids Brief Description K2 National Institute on Drug Abuse