http://www.nejm.org/doi/full/10.1056/NEJMra1103676 http://www.nejm.org/doi/full/10.1056/NEJMra1103676 NEJM review Current Concepts article NEJM review http://www.nejm.org/doi/full/10.1056/NEJMra1103676 http://www.nejm.org/doi/full/10.1056/NEJMra1103676 http://www.nejm.org/doi/full/10.1056/NEJMra1103676 http://www.nejm.org/doi/full/10.1056/NEJMra1103676 http://www.nejm.org/doi/full/10.1056/NEJMra1103676 http://www.nejm.org/doi/full/10.1056/NEJMra1103676 NEJM review