 Backbones, as networks of metabolites connected by the most relevant fluxes, are thus useful to trace simultaneously both  evolution and adaptation fingerprints in cell metabolism .
<clarity>  Backbones, as networks of metabolites connected by the most relevant fluxes, are thus useful to trace simultaneously both  evolution and adaptation fingerprints in cell metabolism .
 Backbones, as networks of metabolites connected by the most relevant fluxes, are thus useful to trace simultaneously both its evolution and adaptation fingerprints in cell metabolism .