 We prove that TFs do not have sufficient combinatorial power to serve as the basis of an addressing system for regulatory control of genomes in the development of URLanisms.
<coherence>  We prove that TFs do not have sufficient combinatorial power to serve as the basis of an addressing system for regulatory control of genomes in the development of URLanisms.
 However, it is shown in this article that transcription factors do not have sufficient combinatorial power to serve as the basis of an addressing system for regulatory control of genomes in the development of URLanisms.