 Conclusions: Abnormal leak results from either a probability imbalance during synchronized firing of RyRs or from disordered RyR firing. Each leak type requires different and balanced treatment to shift RyR operation towards normal spark termination .
<meaning-changed>  Conclusions: Abnormal leak results from either a probability imbalance during synchronized firing of RyRs or from disordered RyR firing. Each leak type requires different and balanced treatment to shift RyR operation towards normal spark termination .
 Thus, in addition to our detailed numerical model approach we also offer an instantaneous computational tool using analytical formulas of the Ising model for respective RyR parameters and SR Ca load that describe and classify phase transitions and leak emergence .