New algorithms for exploiting amino acid covariation have had a large impact on de novo protein modelling. The limited applicability of these methods to smaller protein families has limited their use for structural annotation of whole genomes , however.
<clarity> New algorithms for exploiting amino acid covariation have had a large impact on de novo protein modelling. The limited applicability of these methods to smaller protein families has limited their use for structural annotation of whole genomes , however.
New algorithms for exploiting amino acid covariation methods to small protein families has limited their use for structural annotation of whole genomes , however.