 Backbones, as networks of metabolites connected by the most relevant fluxes, are thus useful to trace simultaneously both  evolution and adaptation fingerprints in cell metabolism .
<meaning-changed>  Backbones, as networks of metabolites connected by the most relevant fluxes, are thus useful to trace simultaneously both  evolution and adaptation fingerprints in cell metabolism .
 The metabolic backbone of URLanism, as a network of metabolites connected by the most relevant fluxes, are thus useful to trace simultaneously both evolution and adaptation fingerprints in cell metabolism .