 Through stochastic Gilliespie simulation with a generic toggle switch model, we demonstrated that the phenomenon also exist for cell phenotype switching . Then we used coupled single cell and population simulations to demonstrate that one can greatly reduce the time and the total amount of antibiotics needed to extinct a bacteria populationwith RA.
<clarity>  Through stochastic Gilliespie simulation with a generic toggle switch model, we demonstrated that the phenomenon also exist for cell phenotype switching . Then we used coupled single cell and population simulations to demonstrate that one can greatly reduce the time and the total amount of antibiotics needed to extinct a bacteria populationwith RA.
 Through stochastic Gilliespie simulation with a generic toggle switch model, we demonstrated that RA exists in the phenotypic switching of a single bacterium. Further, by coupling single cell level and population level simulations, we showed that with RA, one can greatly reduce the time and the total amount of antibiotics needed to extinct a bacteria populationwith RA.