 Backbones, as networks of metabolites connected by the most relevant fluxes, are thus useful to trace simultaneously both  evolution and adaptation fingerprints in cell metabolism .
<fluency>  Backbones, as networks of metabolites connected by the most relevant fluxes, are thus useful to trace simultaneously both  evolution and adaptation fingerprints in cell metabolism .
 Backbones, as networks of metabolites connected by the most relevant fluxes, is thus useful to trace simultaneously both evolution and adaptation fingerprints in cell metabolism .