 Modern cancer therapeutics including immune checkpoint inhibitor therapies are specific to the primary tumor hence broad-spectrum chemotherapy remains the standard-of-care for CUP patients\mbox{%DIFAUXCMD massard2011carcinomas .
<coherence>  Modern cancer therapeutics including immune checkpoint inhibitor therapies are specific to the primary tumor hence broad-spectrum chemotherapy remains the standard-of-care for CUP patients\mbox{%DIFAUXCMD massard2011carcinomas .
 Modern cancer therapeutics including immune checkpoint inhibitor therapies are specific to the primary tumor .