 We quantify the effect of a combined therapy of hyperthermia and a cytotoxic inhibition of proteins refolding .
<meaning-changed>  We quantify the effect of a combined therapy of hyperthermia and a cytotoxic inhibition of proteins refolding .
 We quantify the effect of a combined therapy of hyperthermia and a cytotoxic effect of bortezomib, a proteasome inhibitor, and we propose an optimal strategy for combining these two modalities .