 Many eukaryotic cells were believed to require an underlying substratum to migrate (crawl) by using ample membrane deformation (like blebbing ). There is now an increasing evidence that a large variety of cells (including those of the immune system) can migrate without the assistance of focal adhesion, and can perform swimming as efficiently as crawling .
<meaning-changed>  Many eukaryotic cells were believed to require an underlying substratum to migrate (crawl) by using ample membrane deformation (like blebbing ). There is now an increasing evidence that a large variety of cells (including those of the immune system) can migrate without the assistance of focal adhesion, and can perform swimming as efficiently as crawling .
 Many eukaryotic cells were believed to require an underlying substratum to migrate (crawl) by using ample membrane deformation (like blebbing or generation of lamellipodia) but there is now increasing evidence that a large variety of cells (including those of the immune system) can migrate without the assistance of focal adhesion, and can perform swimming as efficiently as crawling .