 This chapter introduces methods developed by the Rfam database for identifying "families" of homologous ncRNAs  from single "seed" sequences using manually curated  alignments to build powerful statistical models  known as covariance models (CMs)  .
<meaning-changed>  This chapter introduces methods developed by the Rfam database for identifying "families" of homologous ncRNAs  from single "seed" sequences using manually curated  alignments to build powerful statistical models  known as covariance models (CMs)  .
 This chapter introduces methods developed by the Rfam database for identifying "families" of homologous ncRNAs from single "seed" sequences using manually curated alignments to build powerful statistical models known as covariance models (CMs) , implemented in the Infernal software package .