 These backbones maintain all relevant information while displaying a substantially decreased number of interconnections and, hence, they become a useful tool to extract main metabolic highways and so to unveil important biological information.
<fluency>  These backbones maintain all relevant information while displaying a substantially decreased number of interconnections and, hence, they become a useful tool to extract main metabolic highways and so to unveil important biological information.
 The backbone maintains all relevant information while displaying a substantially decreased number of interconnections and, hence, they become a useful tool to extract main metabolic highways and so to unveil important biological information.