 It can also lead to dicentric or acentric chromosomes (chromosomes with two centromeres or no centromere), which  end up breaking up and mutating or being lost  .
<meaning-changed>  It can also lead to dicentric or acentric chromosomes (chromosomes with two centromeres or no centromere), which  end up breaking up and mutating or being lost  .
 It can also lead to dicentric or acentric chromosomes (chromosomes with two centromeres or no centromere), which are inherently unstable and usually end up breaking up and mutating or being lost .