 The limited applicability of these methods to smaller protein families has limited their use for structural annotation of whole genomes , however. Most recently , deep learning techniques have shown promise in allowing  residue-residue contacts to be predicted accurately even for shallow sequence alignments.
<coherence>  The limited applicability of these methods to smaller protein families has limited their use for structural annotation of whole genomes , however. Most recently , deep learning techniques have shown promise in allowing  residue-residue contacts to be predicted accurately even for shallow sequence alignments.
 The limited applicability of these methods to smaller protein families has limited their use for structural annotation of whole genomes . Recently , deep learning techniques have shown promise in allowing residue-residue contacts to be predicted accurately even for shallow sequence alignments.