 We apply it to all Pfam domains without a known structure and provide high confidence models for 25\% of these so-called "dark " families , a calculation that took less than a week on a small cluster with 200 available cores . DMPfold provides models for 16\% of human proteome UniProt entries without structures, can generate accurate models with alignments of fewer than 100 sequences in some cases, and is freely available.
<clarity>  We apply it to all Pfam domains without a known structure and provide high confidence models for 25\% of these so-called "dark " families , a calculation that took less than a week on a small cluster with 200 available cores . DMPfold provides models for 16\% of human proteome UniProt entries without structures, can generate accurate models with alignments of fewer than 100 sequences in some cases, and is freely available.
 We apply it to all Pfam domains without a known structure and provide high confidence models for 25\% of these so-called "dark " families , a calculation that took less than a week on a small cluster with 200 core cluster . DMPfold provides models for 16\% of human proteome UniProt entries without structures, can generate accurate models with alignments of fewer than 100 sequences in some cases, and is freely available.