The growth process of fungal hyphae involves transport of nutrients from the sub-apical region of the fungus to the growing tip of hyphae. At the tip domain, the URLanelle -Spitzenkorper uses the nutrients that are packaged as membrane bound vesicles to synthesize fresh cell wall. This in turn leads to elongation and branching of the hyphae and formation of a single colony mycelium. We propose a driven lattice gas model which incorporates the processes of vesicle supply dependent linear extension and branching of the tips of the hyphae, apart from process of motor driven transport of vesicles along the hyphae towards the growing tips . We first analyze the growth and transport process in the primary hypha  which is subject to particle  loss due to presence of  branching sites. We show that the spatial profile of vesicles along the growing lattice is an exponential distribution, while the length grows logarithmically with time. We also obtain the probability distribution of length of the hypha , and find that it tends to a Gaussian distribution function at late times. In contrast, we find that probability distribution function of the time required for growth to a specific length is a broad log-normal distribution. We simulate the resultant 2-d morphology generated by the growing primary lattice , quantifying the motility behavior and morphological characteristics of the colony in terms of measures such as the Center of Mass, Radius of Gyration and Aspect Ratio . Analysis of the temporal behavior and morphological characteristics of the resultant 2-d morphology reveals a wide variability of these characteristics which depend on the input parameters which characterize the branching and elongation dynamics of the individual hyphae. We make quantitative comparison of the predictions of our model with experiments .
We present a minimal driven lattice gas model which generates the morphological characteristics associated with single colony mycelium arising from the growth and branching process of fungal hyphae, which is fed by a single source of nutrients . We first analyze the growth and transport process in the primary hypha modeled as a growing 1-d lattice, which is subject to particle (vesicle) loss due to presence of dynamically created branching sites. We show that the spatial profile of vesicles along the growing lattice is an exponential distribution, while the length grows logarithmically with time. We also find that the probability distribution of length of the hypha tends to a Gaussian distribution function at late times. In contrast, the probability distribution function of the time required for growth to a specific length tends to a broad log-normal distribution. We simulate the resultant 2-d morphology generated by the growing primary hypha , quantifying the motility behavior and morphological characteristics of the colony . Analysis of the temporal behavior and morphological characteristics of the resultant 2-d morphology reveals a wide variability of these characteristics which depend on the input parameters which characterize the branching and elongation dynamics of the hyphae. By calibrating the input parameters for our model, we make some quantitative comparison of the predictions of our model with the observed experimental growth characteristics of fungal hyphae and the morphological characteristics of single colony fungal mycelium .
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The growth process of fungal hyphae involves transport of nutrients from the sub-apical region of the fungus to the growing tip of hyphae. At the tip domain, the URLanelle -Spitzenkorper uses the nutrients that are packaged as membrane bound vesicles to synthesize fresh cell wall. This in turn leads to elongation and branching of the hyphae and formation of a single colony mycelium. We propose a
We present a minimal
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incorporates the processes of vesicle supply dependent linear extension and branching of the tips of the hyphae, apart from process of motor driven transport of vesicles along the hyphae towards the growing tips
generates the morphological characteristics associated with single colony mycelium arising from the growth and branching process of fungal hyphae, which is fed by a single source of nutrients
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modeled as a growing 1-d lattice,
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(vesicle)
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dynamically created
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obtain
find that
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, and find that it
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we find that
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tends to
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lattice
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in terms of measures such as the Center of Mass, Radius of Gyration and Aspect Ratio
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individual hyphae. We make
hyphae. By calibrating the input parameters for our model, we make some
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experiments
the observed experimental growth characteristics of fungal hyphae and the morphological characteristics of single colony fungal mycelium