Background : Laboratory diagnosis of the novel coronavirus (SARS-CoV-2) infection combined with tracing/ quarantine for contacts of infected individuals affects the spread of SARS-CoV-2 and the  levels of related mortality. Here, we examine the relation between detectability of SARS-CoV-2 infection (i.e. the proportion of detected COVID-19 cases among all cases of  SARS-CoV-2 infection in the population ) and levels of mortality from COVID-19 for the 85 regions of the Russian Federation . Methods: Lower case-fatality ratio ( CFR, the proportion of deaths among all detected COVID-19 cases ) corresponds to higher detectability of the SARS-COV-2 infection . We used data from the Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor) on the number of detected cases and the number of deaths from COVID-19 in the different regions of the Russian Federation to examine the correlation between case-fatality ratios and rates of mortality for COVID-19 in the 85 regions of the Russian Federation. Results: The correlation between case-fatality ratios and rates of mortality for COVID-19 per 100,000 on Sep. 17, 2020 in different regions of the Russian Federation  is 0.68 ( 0.55 ,0.78). The region with both the highest COVID-19 mortality rate per 100, 000 and the highest CFR (lowest detectability of SARS-CoV-2 infection) is the city of St. Petersburg . Conclusions: Detectability of SARS-CoV-2 infection is one of the factors that affects levels of mortality from COVID-19 . Regions of the Russian Federation with relatively low detectability of  SARS-CoV-2 infection (e.g. those regions for which  case-fatality ratio is below the median value of 1.2\% for the case-fatality ratio in different regions of the Russian Federation on Sep. 17 , 2020 [ 3 ]) ought to increase testing for  SARS-CoV-2  in order to mitigate the spread of  SARS-CoV-2  and diminish the related mortality.
Relevance : Laboratory diagnosis of the novel coronavirus (SARS-CoV-2) infection combined with quarantine for contacts of infected individuals affects the spread of the SARS-CoV-2 infection and levels of related mortality. Moreover, not all cases of the SARS-CoV-2 infection in the population are detected (laboratory diagnosed). For example, in the city of St. Petersburg, where mortality rate for COVID-19 is the highest in the Russian Federation on Oct. 1, 2020, every death for COVID-19 corresponds to 14.7 detected cases of COVID-19 in the population, while the corresponding number for the whole of Russia is 56.7, suggesting limited detection of mild/moderate cases of COVID-19 in St. Petersburg. Methods: More active testing for SARS-CoV-2 results in lower case-fatality ratio ( i.e. the proportion of detected COVID-19 cases among all cases of SARS-CoV-2 infection in the population) . We used data on COVID-19 cases and deaths to examine the correlation between case-fatality ratios and rates of mortality for COVID-19 in different regions of the Russian Federation. Results: The correlation between case-fatality ratios and rates of mortality for COVID-19 in different regions of the Russian Federation on Oct. 1, 2020 is 0.68 ( 0.54 ,0.78). For several regions of the Russian Federation, particularly the city of St. Petersburg , detectability of SARS-CoV-2 infection is relatively low, while rates of mortality for COVID-19 are relatively high. Conclusions: Regions of the Russian Federation with relatively low detectability of the SARS-CoV-2 infection (e.g. those regions for which the case-fatality ratio is below the median value of 1.2\% for the case-fatality ratio for COVID-19 in the different regions of the Russian Federation on Oct. 1 , 2020 [ 4 ]) ought to increase testing for the SARS-CoV-2 infection in order to mitigate the spread of the SARS-CoV-2 infection and diminish the related mortality.
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Background
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tracing/
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SARS-CoV-2 and
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SARS-CoV-2 infection and
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Here, we examine the relation between detectability of SARS-CoV-2 infection (i.e. the proportion of detected COVID-19 cases among
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on Oct. 1, 2020, every death for COVID-19 corresponds to 14.7 detected cases of COVID-19 in the population, while the corresponding number for the whole of Russia is 56.7, suggesting limited detection of mild/moderate cases of COVID-19 in St. Petersburg. Methods: More active testing for SARS-CoV-2 results in lower
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from the Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor) on the number of detected cases and the number of deaths from COVID-19 in the different regions of the Russian Federation
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The region with both the highest COVID-19 mortality rate per 100, 000 and the highest CFR (lowest detectability of SARS-CoV-2 infection) is the
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