Background: Laboratory diagnosis of the novel coronavirus (SARS-CoV-2) infection combined with  quarantine for contacts of infected individuals affects the spread of SARS-CoV-2 and the levels of related mortality. Moreover, not all cases of SARS-CoV-2 infection in the population are detected (laboratory diagnosed). The aim of this paper is to examine the relation between detectability of SARS-CoV-2 infection (i.e. the percent of detected cases among all cases of SARS-CoV-2 infection in the population) and levels of mortality from COVID-19 for the different regions of the Russian Federation. Methods: Lower case-fatality ratio ( i.e. the ratio between the number of deaths from COVID-19 and the number of diagnosed casesof SARS-COV-2 infection ) corresponds to higher detectability of the SARS-COV-2 infection. We used data from the Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor) on the number of detected cases and the number of deaths from COVID-19 in the different regions of the Russian Federation to examine the correlation between case-fatality ratios and rates of mortality for COVID-19 in different regions of the Russian Federation. Results: The correlation between case-fatality ratios and rates of mortality for COVID-19  in different regions of the Russian Federation on Sep 6 , 2020 is 0.69 (0.56,0.79). Conclusions: Detectability of SARS-CoV-2 infection is one of the factors that affects levels of mortality from COVID-19. Regions of the Russian Federation with relatively low detectability of SARS-CoV-2 infection (e.g. those regions for which case-fatality ratio is below the median value of 0.0118 for the case-fatality ratio in different regions of the Russian Federation on Sep. 6 , 2020 [3]) ought to increase testing for SARS-CoV-2 in order to mitigate the spread of SARS-CoV-2 and diminish the related mortality.
Background: Laboratory diagnosis of the novel coronavirus (SARS-CoV-2) infection combined with tracing/ quarantine for contacts of infected individuals affects the spread of SARS-CoV-2 and the levels of related mortality. Here, we examine the relation between detectability of SARS-CoV-2 infection (i.e. the proportion of detected COVID-19 cases among all cases of SARS-CoV-2 infection in the population) and levels of mortality from COVID-19 for the 85 regions of the Russian Federation. Methods: Lower case-fatality ratio ( CFR, the proportion of deaths among all detected COVID-19 cases ) corresponds to higher detectability of the SARS-COV-2 infection. We used data from the Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor) on the number of detected cases and the number of deaths from COVID-19 in the different regions of the Russian Federation to examine the correlation between case-fatality ratios and rates of mortality for COVID-19 in the 85 regions of the Russian Federation. Results: The correlation between case-fatality ratios and rates of mortality for COVID-19 per 100,000 on Sep. 17, 2020 in different regions of the Russian Federation is 0.68 (0.55,0.78). The region with both the highest COVID-19 mortality rate per 100 , 000 and the highest CFR (lowest detectability of SARS-CoV-2 infection) is the city of St. Petersburg. Conclusions: Detectability of SARS-CoV-2 infection is one of the factors that affects levels of mortality from COVID-19. Regions of the Russian Federation with relatively low detectability of SARS-CoV-2 infection (e.g. those regions for which case-fatality ratio is below the median value of 1.2\% for the case-fatality ratio in different regions of the Russian Federation on Sep. 17 , 2020 [3]) ought to increase testing for SARS-CoV-2 in order to mitigate the spread of SARS-CoV-2 and diminish the related mortality.
A
tracing/
R
Moreover, not all cases of SARS-CoV-2 infection in the population are detected (laboratory diagnosed). The aim of this paper is to
Here, we
R
percent of detected
proportion of detected COVID-19
R
different
85
R
i.e. the ratio between the number of deaths from
CFR, the proportion of deaths among all detected
R
and the number of diagnosed casesof SARS-COV-2 infection
cases
R
different
the 85
A
per 100,000 on Sep. 17, 2020
R
on Sep 6
is 0.68 (0.55,0.78). The region with both the highest COVID-19 mortality rate per 100
R
2020 is 0.69 (0.56,0.79).
000 and the highest CFR (lowest detectability of SARS-CoV-2 infection) is the city of St. Petersburg.
R
0.0118
1.2\%
R
6
17