We study a fundamental model of DNA evolution in a growing population of cells : cell divisions follow the Yule process, and each cell contains a sequence of nucleotides which can mutate at cell division.  Following typical parameter values in bacteria and cancer cell populations, we take the mutation rate to zero and the final number of cells to infinity. We prove that almost every site (entry of the  sequence) is mutated in only a finite number of cells, and these numbers are independent across sites. However independence breaks down for the rare sites which are mutated in a positive fraction of the population. The model is free from the popular but disputed infinite sites assumption. Violations of the infinite sites assumption are widespread while their impact on mutation frequencies is negligible at the scale of population fractions. Some results are generalised to allow for cell death, selection, and site-specific mutation rates. We also estimate mutation rates in a lung adenocarcinoma.
We study a simple model of DNA evolution in a growing population of cells . Each cell contains a nucleotide sequence which randomly mutates at cell division. Cells divide according to a branching process. Following typical parameter values in bacteria and cancer cell populations, we take the mutation rate to zero and the final number of cells to infinity. We prove that almost every site (entry of the nucleotide sequence) is mutated in only a finite number of cells, and these numbers are independent across sites. However independence breaks down for the rare sites which are mutated in a positive fraction of the population. The model is free from the popular but disputed infinite sites assumption. Violations of the infinite sites assumption are widespread while their impact on mutation frequencies is negligible at the scale of population fractions. Some results are generalised to allow for cell death, selection, and site-specific mutation rates. For illustration we estimate mutation rates in a lung adenocarcinoma.
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fundamental
simple
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: cell divisions follow the Yule process, and each cell contains a sequence of nucleotides which can mutate
. Each cell contains a nucleotide sequence which randomly mutates
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Cells divide according to a branching process.
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nucleotide
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We also
For illustration we