Human olfactory receptor , OR1D2, binds to Bourgeonal , a chemical constituent of the mythical flower, Lily of the valley or Our Lady's tears (1) . OR1D2, OR1D4 and OR1D5 are three full length olfactory receptors present in an olfactory locus in human genome. These receptors are more than 80\% identical in DNA sequences and have 107 base pair mismatches among them. Apparently, these mismatch positions show no striking pattern using computer pattern recognition tools. In an attempt to find a mathematical rule in those mismatches, we find that L-system generated sequence can be inserted into the OR1D2 subfamily specific star model and novel full length olfactory receptors can be generated. This remarkable mathematical principle could be utilized for making new subfamily OR members from any OR subfamily. Aroma and electronic nose industry might utilize this rule in a large way in near future .
Ligands for only two human olfactory receptors are known. One of them , OR1D2, binds to Bourgeonal Malnic B, Godfrey P-A, Buck L-B (2004) The human olfactory receptor gene family. Proc. Natl. Acad. Sci U. S. A. 101: 2584-2589 and Erratum in: Proc Natl Acad Sci U. S. A. (2004) 101: 7205 . OR1D2, OR1D4 and OR1D5 are three full length olfactory receptors present in an olfactory locus in human genome. These receptors are more than 80\% identical in DNA sequences and have 108 base pair mismatches among them. We have used L-system mathematics and have been able to show a closely related subfamily of OR1D2, OR1D4 and OR1D5 .
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Human olfactory receptor
Ligands for only two human olfactory receptors are known. One of them
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, a chemical constituent of the mythical flower, Lily of the valley or Our Lady's tears (1)
Malnic B, Godfrey P-A, Buck L-B (2004) The human olfactory receptor gene family. Proc. Natl. Acad. Sci U. S. A. 101: 2584-2589 and Erratum in: Proc Natl Acad Sci U. S. A. (2004) 101: 7205
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107
108
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Apparently, these mismatch positions show no striking pattern using computer pattern recognition tools. In an attempt to find a mathematical rule in those mismatches, we find that
We have used
R
generated sequence can be inserted into the OR1D2 subfamily specific star model and novel full length olfactory receptors can be generated. This remarkable mathematical principle could be utilized for making new subfamily OR members from any OR subfamily. Aroma and electronic nose industry might utilize this rule in a large way in near future
mathematics and have been able to show a closely related subfamily of OR1D2, OR1D4 and OR1D5