Ca^{2+} signaling is crucial for feedback of a URLanism to external stimulation. In intracellular space, Ca^{2+ the signal may become a global signal fast, and die away in the propagation. To keep the locality of Ca^{2+} signal, the penetrability of is found at an order of magnitude of }\mum Ca^{2+} signal in intracellular space can be regulated through adjusting the initial speed of Ca^{2+ .
Ca^{2+} plays important role in cell signal transduction. Its intracellular propagation is the most basic process of Ca^{2+ the 3-dimensional probability distribution of Ca^{2+} which is read out by phosphorylation is studied in two scenarios with simulation and mean field ansatz. The coverage of distribution of Ca^{2+ is found at an order of magnitude of }\mum, which is consistent with experimental observed calcium spike and wave. Our results suggest that the double messenger system may occur in the ER-PM junction to acquire great efficiency. The buffer effect of kinase is also discussed by calculating the average position of phosphorylations and free Ca^{2+ Ca^{2+} signaling .
R
signaling is crucial for feedback of a URLanism to external stimulation. In intracellular space, Ca^{2+
plays important role in cell signal transduction. Its intracellular propagation is the most basic process of Ca^{2+
R
signal may become a global signal fast, and die away in the propagation. To keep the locality of
3-dimensional probability distribution of
R
signal, the penetrability of
which is read out by phosphorylation is studied in two scenarios with simulation and mean field ansatz. The coverage of distribution of Ca^{2+
A
, which is consistent with experimental observed calcium spike and wave. Our results suggest that the double messenger system may occur in the ER-PM junction to acquire great efficiency. The buffer effect of kinase is also discussed by calculating the average position of phosphorylations and free Ca^{2+
R
signal in intracellular space can be regulated through adjusting the initial speed of Ca^{2+
signaling