The mechanism of glucose transport across membrane is studied from the point of quantum conformational transition. The structural variations among four kinds of conformations of the  transporter GLUT1 (ligand free occluded, outward open, ligand bound occluded , and inward open) are looked as the quantum transition. The comparative studies between mechanisms of uniporter (GLUT1) and symporter (XylE  ) are given. The transitional rates are calculated from the fundamental theory. The glucose transport dynamics is proposed. The steady state of the transporter is found and its stability is demonstrated . The glucose  translocation rates in two directions and in different steps of the transition are compared. The mean transport time in a cycle is calculated  . The non-Arrhenius temperature dependence of the transition rate and the temperature relation for the mean transport time are predicted. It is suggested that the direct measurement of temperature dependence is a useful tool for deeply understanding the transmembrane transport mechanism.
After a brief review of the protein folding quantum theory and a short discussion on its experimental evidences the mechanism of glucose transport across membrane is studied from the point of quantum conformational transition. The structural variations among four kinds of conformations of the human glucose transporter GLUT1 (ligand free occluded, outward open, ligand bound occluded and inward open) are looked as the quantum transition. The comparative studies between mechanisms of uniporter (GLUT1) and symporter (XylE and GlcP ) are given. The transitional rates are calculated from the fundamental theory. The monosaccharide transport kinetics is proposed. The steady state of the transporter is found and its stability is studied . The glucose (xylose) translocation rates in two directions and in different steps are compared. The mean transport time in a cycle is calculated and based on it the comparison of the transport times between GLUT1,GlcP and XylE can be drawn . The non-Arrhenius temperature dependence of the transition rate and the mean transport time is predicted. It is suggested that the direct measurement of temperature dependence is a useful tool for deeply understanding the transmembrane transport mechanism.
R
The
After a brief review of the protein folding quantum theory and a short discussion on its experimental evidences the
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human glucose
D
,
A
and GlcP
R
glucose transport dynamics
monosaccharide transport kinetics
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demonstrated
studied
A
(xylose)
D
of the transition
A
and based on it the comparison of the transport times between GLUT1,GlcP and XylE can be drawn
D
temperature relation for the
R
are
is