Transcranial magnetic stimulation (TMS) has widespread clinical applications from diagnosis to treatment approaches. We combined TMS with non-contact magnetic detection of TMS-evoked muscle activity in peripheral limbs to explore a new diagnostic modality that enhances the utility of TMS as a clinical tool by leveraging technological advances in magnetometry. We recorded measurements inside of a hospital using an array of optically pumped magnetometers ( OPMs ) inside a portable shield that encompasses only the forearm and hand of the subject. We present magnetomyograms (MMG)s of TMS-evoked movement in a human hand, together with a simultaneous surface electromyograph (EMG) and electroencephalograph (EEG) data. The biomagnetic signals recorded in the MMG provides detailed spatial and temporal information that is complementary to that of the electric signal channels. Moreover, we identify features in the magnetic recording beyond that of the EMG , at time points which we further analyze in the EEG. This system demonstrates the value of biomagnetic signals in TMS-based clinical approaches and widens its availability and practical potential .
Objective: We present magnetomyograms (MMG) of TMS-evoked movement in a human hand, together with a simultaneous surface electromyograph (EMG) and electroencephalograph (EEG) data. Approach: We combined TMS with non-contact magnetic detection of TMS-evoked muscle activity in peripheral limbs to explore a new diagnostic modality that enhances the utility of TMS as a clinical tool by leveraging technological advances in magnetometry. We recorded measurements in a regular hospital room using an array of optically pumped magnetometers ( OPM ) inside a portable shield that encompasses only the forearm and hand of the subject. Main Results: The biomagnetic signals recorded in the MMG provide detailed spatial and temporal information that is complementary to that of the electric signal channels. Moreover, we identify features in the magnetic recording beyond those of the EMG . Significance: These results validate the viability of MMG recording with a compact OPM based setup in small-sized magnetic shielding, and provide proof-of-principle for a non-contact data channel for detection and analysis of TMS-evoked muscle activity from peripheral limbs .
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Transcranial magnetic stimulation (TMS) has widespread clinical applications from diagnosis to treatment approaches.
Objective: We present magnetomyograms (MMG) of TMS-evoked movement in a human hand, together with a simultaneous surface electromyograph (EMG) and electroencephalograph (EEG) data. Approach:
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inside of a hospital
in a regular hospital room
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OPMs
OPM
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We present magnetomyograms (MMG)s of TMS-evoked movement in a human hand, together with a simultaneous surface electromyograph (EMG) and electroencephalograph (EEG) data.
Main Results:
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provides
provide
R
that
those
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, at time points which we further analyze in the EEG. This system demonstrates the value of biomagnetic signals in TMS-based clinical approaches and widens its availability and practical potential
. Significance: These results validate the viability of MMG recording with a compact OPM based setup in small-sized magnetic shielding, and provide proof-of-principle for a non-contact data channel for detection and analysis of TMS-evoked muscle activity from peripheral limbs