Translocation of a single stranded DNA through genetically engineered \alpha-hemolysin channels with positively charged walls is studied. It is predicted that transport properties of such channels are dramatically different from the neutral wild type \alpha-hemolysin channel. We assume that the wall charges compensate the fraction x of the bare charge q_{b} of the DNA piece residing in the channel. Our prediction are as follows (i) At small concentration of salt the blocked ion current decreases with x. (ii) The effective charge q of DNA piece  grows with x and at q_{b x= 1. (iii) The rate of DNA capture by the channel exponentially grows with x. Our theory is also applicable to translocation of a double stranded DNA in narrow solid state nanopores with positively charged walls.
Translocation of a single stranded DNA through genetically engineered \alpha-hemolysin channels with positively charged walls is studied. It is predicted that transport properties of such channels are dramatically different from neutral wild type \alpha-hemolysin channel. We assume that the wall charges compensate the fraction x of the bare charge q_{b} of the DNA piece residing in the channel. Our prediction are as follows (i) At small concentration of salt the blocked ion current decreases with x. (ii) The effective charge q of DNA piece , which is very small at x = 0 (neutral channel) grows with x and at x= 1 reaches q_{b (iii) The rate of DNA capture by the channel exponentially grows with x. Our theory is also applicable to translocation of a double stranded DNA in narrow solid state nanopores with positively charged walls.
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