Deformation of single stranded DNA  before reaching the pore in translocation process is investigated. By solving the Laplace equation in a suitable coordinate system and with appropriate boundary conditions, an approximate solution for  electric field inside and outside of a narrow pore is obtained. With an analysis based on "electrohydrodynamic equivalence" we determine the possibility of extension of a charged polymer due to the presence of  electric field gradient in the vicinity of the pore entrance. Such deformation is shown to have a great contribution on the capturing process, first stage of any translocation phenomena. With a multiscale hybrid simulation (LB-MD)  it is shown that an effective deformation before reaching the pore occurs which facilitates the process of finding the entrance for the end monomers  .
Deformation of single stranded DNA in translocation process before reaching the pore is investigated. By solving the Laplace equation in a suitable coordinate system and with appropriate boundary conditions, an approximate solution for the electric field inside and outside of a narrow pore is obtained. With an analysis based on "electrohydrodynamic equivalence" we determine the possibility of extension of a charged polymer due to the presence of an electric field gradient in the vicinity of the pore entrance. With a multi-scale hybrid simulation (LB-MD) , it is shown that an effective deformation before reaching the pore occurs which facilitates the process of finding the entrance for the end monomers . We also highlight the role of long range hydrodynamic interactions via comparison of the LB-MD results with those obtained using a Langevin thermostat instead of the LB solver .
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Such deformation is shown to have a great contribution on the capturing process, first stage of any translocation phenomena. With a multiscale
With a multi-scale
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. We also highlight the role of long range hydrodynamic interactions via comparison of the LB-MD results with those obtained using a Langevin thermostat instead of the LB solver