We study physical limits of chemical sensing by a single chemotactic cell with cooperative chemoreceptors on the cell surface . We derive general formula for the gradient sensing limit from the uncertainty in instantaneous receptor activity configurations and find that cooperativity by non-adaptive receptors could significantly lower the sensing limit at the biochemically-relevant regime of balanced free energy difference between active and inactive receptor states . Cooperativity by adaptive receptors are beneficial to gradient sensing under a broad range of background concentrations. Our results also show that isotropic receptor aggregate layout  represents an optimal configuration to gradient sensing and that anisotropy does not change the effect of receptor cooperativity on the sensing limit .
Most sensory cells use cross-membrane chemoreceptors to detect chemical signals in the environment. The biochemical properties and URLanization of chemoreceptors play important roles in achieving and maintaining sensitivity and accuracy of chemical sensing. Here we investigate the effects of receptor cooperativity and adaptation on the limits of gradient sensing. We study a single cell with aggregated chemoreceptor arrays on the cell surface and derive general formula to the limits for gradient sensing from the uncertainty of instantaneous receptor activity . In comparison to independent receptors, we find that cooperativity by non-adaptative receptors could significantly lower the sensing limit in a chemical concentration range determined by the biochemical properties of ligand-receptor binding and ligand-induced receptor activity . Cooperativity by adaptative receptors are beneficial to gradient sensing within a broad range of background concentrations. Our results also show that isotropic receptor aggregate layout on the cell surface represents an optimal configuration to gradient sensing .
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We study physical limits of chemical sensing by a single chemotactic cell with cooperative chemoreceptors
Most sensory cells use cross-membrane chemoreceptors to detect chemical signals in the environment. The biochemical properties and URLanization of chemoreceptors play important roles in achieving and maintaining sensitivity and accuracy of chemical sensing. Here we investigate the effects of receptor cooperativity and adaptation on the limits of gradient sensing. We study a single cell with aggregated chemoreceptor arrays
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and that anisotropy does not change the effect of receptor cooperativity on the sensing limit