Autophagy is a conserved biological stress response in mammalian cells that is responsible for clearing damaged proteins URLanelles from the cytoplasm and recycling their contents via the lysosomal pathway. In cases where the stressis not too severe , autophagy acts as a survival mechanism . In cases of severe stress , may lead to programmed cell death. There is also a third alternative, autophagic cell death, which can occur when the apoptotic pathway is blocked. Autophagy is abnormally regulated in a wide-range of diseases, including cancer. To integrate the existing knowledge about this decision process into a rigorous, analytical framework, we built a mathematical model of cell fate decision mediated by autophagy. The model treats autophagy as a gradual response to stress that delays the initiation of apoptosis to give the cell an opportunity to survive. We show that our dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment .
Autophagy is a conserved biological stress response in mammalian cells that is responsible for clearing damaged proteins URLanelles from the cytoplasm and recycling their contents via the lysosomal pathway. In cases of mild stress , autophagy acts as a survival mechanism , while in cases of severe stress cells may switch to programmed cell death. Understanding the decision process that moves a cell from autophagy to apoptosis is important since abnormal regulation of autophagy occurs in many diseases, including cancer. To integrate existing knowledge about this decision process into a rigorous, analytical framework, we built a mathematical model of cell fate decisions mediated by autophagy. Our dynamical model is consistent with existing quantitative measurements of autophagy and apoptosis in rat kidney proximal tubular cells responding to cisplatin-induced stress .
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There is also a third alternative, autophagic cell death, which can occur when the apoptotic pathway is blocked. Autophagy is abnormally regulated in a wide-range of
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The model treats autophagy as a gradual response to stress that delays the initiation of apoptosis to give the cell an opportunity to survive. We show that our
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time courses of autophagic responses to cisplatin treatment
autophagy and apoptosis in rat kidney proximal tubular cells responding to cisplatin-induced stress