Xanthones are known to the Chemistry and Pharmacology industries for its potential use as an anti-depressant.Apaydin EA, Maher AR, Shanman R, Booth MS, Miles JNV, Sorbero ME, Hempe S (2016-12-10). "A systematic review of St. John's wort for major depressive disorder". Systematic Reviews. 5 (1): 148. doi:10.1186/s13643-016-0325-2. ISSN 2046-4053. PMC 5010734. PMID 27589952. It has also been found to actively treat fungal infections on human skin. Wölfle U, Seelinger G, Schempp C (2013-11-08). "Topical Application of St. Johnʼs Wort (Hypericum perforatum)". Planta Medica. 80 (02/03): 109–120. doi:10.1055/s-0033-1351019. ISSN 0032-0943.Xanthone derivatives are being used to generate new pharmacological products as they have a close link with Acetyl Coenzyme A (Acetyl CoA).Liu B, Falkenstein-Pau H, Hildegard SW, Beerhues L (2003-06-27). "Benzophenone synthase and chalcone synthase from Hypericum androsaemum cell cultures: cDNA cloning, functional expression, and site-directed mutagenesis of two polyketide synthases". The Plant Journal. 34 (6): 847–855. doi:10.1046/j.1365-313X.2003.01771.x. The carbon backbone for Xanthones is formed by Benzophenone synthase (BPS) and through a series of oxidation and condensation reactions, Xanthones are produced. Xanthone messenger RNA and associated proteins are localized to the exodermis and Endodermis systems. Xanthone Similar to other parts of the root system, the concentration of these molecules is dependent on the genetic variation and the environmental factors.Toccin N, Simonetti G, D’Auria FD, Panella S, Palamara AT, Valletta A, Pasqua G (2011-08-06). "Root cultures of Hypericum perforatum subsp. angustifolium elicited with chitosan and production of xanthone-rich extracts with antifungal activity". Applied Microbiology and Biotechnology. 91 (4): 977–987. doi:10.1007/s00253-011-3303-6. ISSN 0175-7598. The exodermis is involved in preventing the entry of pathogens into the cortex of the plant. In the root system with bacterial infections and invasion from rhizogenes, the concentration of BPS increases to fight off the pathogens.Tusevsk O, Petreska SJ, Stefova M, Simic SG (2013). "Phenolic Profile of Dark-Grown and Photoperiod-Exposed Hypericum perforatum L. Hairy Root Cultures". The Scientific World Journal. 2013: 1–9. doi:10.1155/2013/602752. ISSN 1537-744X. PMC 3888740. PMID 24453880. Particularly high concentrations of Xanthones was also found in aerial root systems. Suberin Endodermis Cortex
Xanthones are known to the Chemistry and Pharmacology industries for its potential use as an anti-depressant.Apaydin EA, Maher AR, Shanman R, Booth MS, Miles JNV, Sorbero ME, Hempe S (2016-12-10). "A systematic review of St. John's wort for major depressive disorder". Systematic Reviews. 5 (1): 148. doi:10.1186/s13643-016-0325-2. ISSN 2046-4053. PMC 5010734. PMID 27589952. It has also been found to actively treat fungal infections on human skin. Wölfle U, Seelinger G, Schempp C (2013-11-08). "Topical Application of St. Johnʼs Wort (Hypericum perforatum)". Planta Medica. 80 (02/03): 109–120. doi:10.1055/s-0033-1351019. ISSN 0032-0943.Xanthone derivatives are being used to generate new pharmacological products as they have a close link with Acetyl Coenzyme A (Acetyl CoA).Liu B, Falkenstein-Pau H, Hildegard SW, Beerhues L (2003-06-27). "Benzophenone synthase and chalcone synthase from Hypericum androsaemum cell cultures: cDNA cloning, functional expression, and site-directed mutagenesis of two polyketide synthases". The Plant Journal. 34 (6): 847–855. doi:10.1046/j.1365-313X.2003.01771.x. The carbon backbone for xanthones is formed by Benzophenone synthase (BPS) and through a series of oxidation and condensation reactions, xanthones are produced. Xanthone messenger RNA and associated proteins are localized to the exodermis and Endodermis systems. Xanthone Similar to other parts of the root system, the concentration of these molecules is dependent on the genetic variation and the environmental factors.Toccin N, Simonetti G, D’Auria FD, Panella S, Palamara AT, Valletta A, Pasqua G (2011-08-06). "Root cultures of Hypericum perforatum subsp. angustifolium elicited with chitosan and production of xanthone-rich extracts with antifungal activity". Applied Microbiology and Biotechnology. 91 (4): 977–987. doi:10.1007/s00253-011-3303-6. ISSN 0175-7598. The exodermis is involved in preventing the entry of pathogens into the cortex of the plant. In the root system with bacterial infections and invasion from rhizogenes, the concentration of BPS increases to fight off the pathogens.Tusevsk O, Petreska SJ, Stefova M, Simic SG (2013). "Phenolic Profile of Dark-Grown and Photoperiod-Exposed Hypericum perforatum L. Hairy Root Cultures". The Scientific World Journal. 2013: 1–9. doi:10.1155/2013/602752. ISSN 1537-744X. PMC 3888740. PMID 24453880. Particularly high concentrations of xanthones was also found in aerial root systems. Suberin Endodermis Cortex
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