A biological system is considered homeostatic when there is a regulated variable that is maintained within a narrow range of values. A closely related notion of adaptation can be defined as a process where a system initially responds to a stimulus, but then returns to basal or near-basal levels of activity after some period of time. Adaptation of the chemotaxis sensory pathway of the bacterium Escherichia coli is essential for detecting chemicals over a wide range of background concentrations, ultimately allowing cells to swim towards sources of attractant and away from repellents. Since bacterial chemotaxis is a paradigm for adaptation or homeostasis, we use it as a model system to base the development of a general theory for the analysis of homeostasis in coupled dynamical systems associated with input-output networks with multiple input nodes. This theory allows one to define and classify homeostasis types of a given network in a model independent fashion, in the sense that it depends only on the network topology and not on the specific model equations. Each homeostasis type represents a possible mechanism for generating homeostasis and is associated with a suitable subnetwork motif. Within this framework it is also possible to formalize a notion of generic property of a coupled dynamical system, generalizing the notion of robustness. Finally, we apply our theory to a  model of Escherichia coli chemotaxis and show that, from this abstract point of view, adaptation or homeostasis in this model is caused by a mechanism that we called input counterweight. This new homeostasis mechanism is generated by a balancing between the several input nodes of the network and requires the existence of at least two input nodes.
A biological system is considered homeostatic when there is a regulated variable that is maintained within a narrow range of values. A closely related notion of adaptation can be defined as a process where a system initially responds to a stimulus, but then returns to basal or near-basal levels of activity after some period of time. Adaptation of the chemotaxis sensory pathway of the bacterium Escherichia coli is essential for detecting chemicals over a wide range of background concentrations, ultimately allowing cells to swim towards sources of attractant and away from repellents. Since bacterial chemotaxis is a paradigm for adaptation or homeostasis, we use it as a model system to base the development of a general theory for the analysis of homeostasis in coupled dynamical systems associated with input-output networks with multiple input nodes. This theory allows one to define and classify homeostasis types of a given network in a model independent fashion, in the sense that it depends only on the network topology and not on the specific model equations. Each homeostasis type represents a possible mechanism for generating homeostasis and is associated with a suitable subnetwork motif. Within this framework it is also possible to formalize a notion of generic property of a coupled dynamical system, generalizing the notion of robustness. Finally, we apply our theory to a specific model of Escherichia coli chemotaxis and show that, from our abstract point of view, adaptation or homeostasis in the model is caused by a mechanism that we called input counterweight. This new homeostasis mechanism is generated by a balancing between the several input nodes of the network and requires the existence of at least two input nodes.
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