Ribosome is a molecular machine that moves on a mRNA track while, simultaneously, polymerizing a protein using the mRNA also as the corresponding template. We introduce quantitative measures of its performance which characterize, for example, the speed and fidelity of the template-dictated polymerization. We also define two different measures of efficiency and strength of mechano-chemical coupling of this molecular machine. We calculate all these quantities analytically . Some of these quantities show apparently counterintuitive trends of variation with the qualityof kinetic proofreading. We interpret the origin of these trends . We  suggest new experiments for testing some of the ideas presented here.
Ribosome is a molecular machine that moves on a mRNA track while, simultaneously, polymerizing a protein using the mRNA also as the corresponding template. We define, and analytically calculate, two different measures of the efficiency of this machine . However, we arugue that its performance is evaluated better in terms of the translational fidelity and the speed with which it polymerizes a protein. We define both these quantities and calculate these analytically. Fidelity is a measure of the quality of the products while the total quantity of products synthesized in a given interval depends on the speed of polymerization. We show that for synthesizing a large quantity of proteins, it is not necessary to sacrifice the quality . We also explore the effects of the quality control mechanism on the strength of mechano-chemical coupling. We suggest experiments for testing some of the ideas presented here.
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introduce quantitative measures of its performance which characterize, for example, the speed and fidelity of the template-dictated polymerization. We also define
define, and analytically calculate,
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efficiency and strength of mechano-chemical coupling of this molecular machine. We calculate all these quantities analytically
the efficiency of this machine
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Some of these quantities show apparently counterintuitive trends of variation with the qualityof kinetic proofreading. We interpret the origin of these trends
However, we arugue that its performance is evaluated better in terms of the translational fidelity and the speed with which it polymerizes a protein. We define both these quantities and calculate these analytically. Fidelity is a measure of the quality of the products while the total quantity of products synthesized in a given interval depends on the speed of polymerization. We show that for synthesizing a large quantity of proteins, it is not necessary to sacrifice the quality
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also explore the effects of the quality control mechanism on the strength of mechano-chemical coupling. We
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new