Fractal globule state is widely believed to be the best known model to describe the chromatin packing in the eucaryotic nuclei. Here we provide a scaling theory and dissipative particle dynamics (DPD) computer simulation for the thermal motion of monomers in the fractal globule state. We show this motion to be subdiffusive described by \langle X^2 (t)\rangle \sim t^{\alpha_F} with \alpha_F close to 0.4. We also suggest a novel way to construct a fractal globule state in computer simulation, and provide simulation evidence supporting the conjecture that different initial entanglement-free states of a polymer chain converge as they are thermally annealed .
The fractal globule state is a popular model for describing chromatin packing in eukaryotic nuclei. Here we provide a scaling theory and dissipative particle dynamics (DPD) computer simulation for the thermal motion of monomers in the fractal globule state. Simulations starting from different entanglement-free initial states show good convergence which provides evidence supporting the existence of unique metastable fractal globule state. We show monomer motion in this state to be sub-diffusive described by \langle X^2 (t)\rangle \sim t^{\alpha_F} with \alpha_F close to 0.4. This result is in good agreement with existing experimental data on the chromatin dynamics which makes an additional argument in support of the fractal globule model of chromatin packing .
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Fractal
The fractal
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widely believed to be the best known model to describe the
a popular model for describing
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the eucaryotic
eukaryotic
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We show this motion to be subdiffusive
Simulations starting from different entanglement-free initial states show good convergence which provides evidence supporting the existence of unique metastable fractal globule state. We show monomer motion in this state to be sub-diffusive
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We also suggest a novel way to construct a fractal globule state in computer simulation, and provide simulation evidence supporting the conjecture that different initial entanglement-free states of a polymer chain converge as they are thermally annealed
This result is in good agreement with existing experimental data on the chromatin dynamics which makes an additional argument in support of the fractal globule model of chromatin packing