Gilbert's syndrome (GS) is a  liver disorder in which the liver does not properly process bilirubin. Many people don’t experience symptomsuntil onset of stress, lack of sleep, not eating, toxin build up, alcohol or drug consumption, vinegar/fermented foods, preservatives, vanilla and foods or drinks used to flush the primary detoxification pathway . Occasionally a slight yellowish color of the skin or whites of the eyes may occur. Other possible symptoms include feeling tired, weakness, sickness, headaches, abdominal painand frequent vomiting when toxin overload which can lead to dehydration and fatigue . Gilbert's syndrome is due to a mutation in the UGT1A1 gene which results in decreased activity of the bilirubin uridine diphosphate glucuronosyltransferase enzyme. It is typically inherited in an autosomal recessive pattern and occasionally in an autosomal dominant pattern depending on the type of mutation. Episodes of jaundice and unwell ness/fatigue may be triggered by stress such as over exercising , menstruation, or not eating. Diagnosis is based on higher levels of unconjugated bilirubin in the blood without either signs of other liver problems or red blood cell breakdown. Adequate sleep, stress management/avoidance, healthy diet limiting gluten, sugars and toxins. Gilbert's syndrome affects about 5\% of people in the United States. Males are more often diagnosed than females. It is often not noticed until late childhood to early adulthood. The condition was first described in 1901 by Augustin Nicolas Gilbert.
Gilbert's syndrome (GS) is a mild liver disorder in which the liver does not properly process bilirubin. Many people never have symptoms . Occasionally a slight yellowish color of the skin or whites of the eyes may occur. Other possible symptoms include feeling tired, weakness, and abdominal pain . Gilbert's syndrome is due to a mutation in the UGT1A1 gene which results in decreased activity of the bilirubin uridine diphosphate glucuronosyltransferase enzyme. It is typically inherited in an autosomal recessive pattern and occasionally in an autosomal dominant pattern depending on the type of mutation. Episodes of jaundice may be triggered by stress such as exercise , menstruation, or not eating. Diagnosis is based on higher levels of unconjugated bilirubin in the blood without either signs of other liver problems or red blood cell breakdown. Typically no treatment is needed. If jaundice is significant phenobarbital may be used. Gilbert's syndrome affects about 5\% of people in the United States. Males are more often diagnosed than females. It is often not noticed until late childhood to early adulthood. The condition was first described in 1901 by Augustin Nicolas Gilbert.
A
mild
R
don’t experience symptomsuntil onset of stress, lack of sleep, not eating, toxin build up, alcohol or drug consumption, vinegar/fermented foods, preservatives, vanilla and foods or drinks used to flush the primary detoxification pathway
never have symptoms
R
sickness, headaches, abdominal painand frequent vomiting when toxin overload which can lead to dehydration and fatigue
and abdominal pain
D
and unwell ness/fatigue
R
over exercising
exercise
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Adequate sleep, stress management/avoidance, healthy diet limiting gluten, sugars and toxins.
Typically no treatment is needed. If jaundice is significant phenobarbital may be used.