 Inspired by biological processes such as protein synthesis  and motor protein transport, we intro- duce the concept of localized dynamical sites coupled to a driven lattice gas dynamics. By mimicking a local structural change in the lattice, these sites interact with particles and strongly influence their transport phenomenology. We analyze the case of a single dynamical site whose dynamics is cou- pled with the density of particles on the lattice; we investigate the phenomenology of the model and how the current-density relationship is affected by the dynamical defect. Crucially, we find a novel dynamical regime characterized by an intermittent current and subject to severe finite-size effects that can enhance the transport at high particle densities. We describe and rationalize the variety of regimes via refined mean-field approaches .
Many transport processes in nature take place on substrates, often considered as unidimensional lanes. These unidimensional substrates are typically non-static: affected by a fluctuating environment, they can undergo conformational changes. This is particularly true in biological cells, where the state of the substrate is often coupled to the active motion of macromolecular complexes, such as motor proteins on microtubules or ribosomes on mRNAs, causing new interesting phenomena. Inspired by biological processes such as protein synthesis by ribosomes and motor protein transport, we introduce the concept of localized dynamical sites coupled to a driven lattice gas dynamics. We investigate the phenomenology of transport in the presence of dynamical defects and find a novel regime characterized by an intermittent current and subject to severe finite-size effects . Our results demonstrate the impact of the regulatory role of the dynamical defects in transport, not only in biology but also in more general contexts .
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Many transport processes in nature take place on substrates, often considered as unidimensional lanes. These unidimensional substrates are typically non-static: affected by a fluctuating environment, they can undergo conformational changes. This is particularly true in biological cells, where the state of the substrate is often coupled to the active motion of macromolecular complexes, such as motor proteins on microtubules or ribosomes on mRNAs, causing new interesting phenomena.
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by ribosomes
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intro- duce
introduce
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By mimicking a local structural change in the lattice, these sites interact with particles and strongly influence their transport phenomenology. We analyze the case of a single dynamical site whose dynamics is cou- pled with the density of particles on the lattice; we
We
R
the model and how the current-density relationship is affected by the dynamical defect. Crucially, we
transport in the presence of dynamical defects and
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dynamical
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that can enhance the transport at high particle densities. We describe and rationalize the variety of regimes via refined mean-field approaches
. Our results demonstrate the impact of the regulatory role of the dynamical defects in transport, not only in biology but also in more general contexts