Validation of data sets Samples are used to provide allele frequency estimates for populations. For HLA loci, the presence of ambiguities and that of putative recessive-like undetected alleles require the assumption of Hardy-Weinberg . HLA-NET explicitly requests that frequency estimates, for alleles or haplotypes, be validated by checking their conformity with Hardy-Weinberg expectations. If Hardy-Weinberg equilibrium is rejected then the frequencies can not be taken as representative of the population. The causes for deviation should be looked for and, if possible, addressed. In any case, non Hardy-Weinberg frequencies should never be used as valid population estimates.
Validation of data sets Samples are used to provide allele frequency estimates for populations. For HLA loci, the presence of ambiguities and that of putative recessive-like undetected alleles require the assumption of Hardy–Weinberg . HLA-NET explicitly requests that frequency estimates, for alleles or haplotypes, be validated by checking their conformity with Hardy–Weinberg expectations. If Hardy–Weinberg equilibrium is rejected then the frequencies can not be taken as representative of the population. The causes for deviation should be looked for and, if possible, addressed. In any case, non Hardy–Weinberg frequencies should never be used as valid population estimates.
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Hardy-Weinberg
Hardy–Weinberg
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Hardy-Weinberg
Hardy–Weinberg
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Hardy-Weinberg
Hardy–Weinberg
R
Hardy-Weinberg
Hardy–Weinberg