Adhesion molecules play an integral role in diverse biological functions ranging from cellular growth to transport . Estimation of their binding affinity , therefore, becomes important to quantify their biophysical impact on these phenomena. In this paper , we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships to tease out adhesion energy from vesicle-substrate experiments . Our study reveals that the inverse of the height, exponential of the contact area, and the force required to detach the vesicle from the substrate vary linearly with the square root of the adhesion energy  . We validate the modeling predictions with experimental data from two previous studies.
Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development . Estimation of adhesion strength , therefore, becomes important to gain biophysical insight into these phenomena. In this Letter , we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle-substrate interactions . Our study reveals that the inverse of the height, exponential of the contact area, and the force required to detach the vesicle from the substrate vary linearly with the square root of the adhesion energy . These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles . We validate the modeling predictions with experimental data from two previous studies.
R
molecules play
plays
R
growth to transport
transport to tissue development
R
their binding affinity
adhesion strength
R
quantify their biophysical impact on
gain biophysical insight into
R
paper
Letter
R
to tease out adhesion energy from
that capture
R
experiments
interactions
A
. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles