While the positive pressure isolator is most common, "negative" pressure devices also exist for very large industrial operations that handle toxic products.  A simpler and more effective option for most toxicological containment applications is the use of "closed isolator" design (this positive pressure isolator is the most appropriate containment option unless a company is processing thousands of units per minute). When a negative isolator js used, its design is quite intricate as it must fulfill two objectives: protect workers outside of the isolator, and assure sterility of sterile drugs inside the isolator. As such, the term "negative pressure" isolator is somewhat of a misnomer, as contaminated ("polluted") room air must not be pulled into the main workstation isolator in a sterile operation. Thus, the actual workstation isolator is always maintained under substantial positive pressure. The "negative" pressure isolator does however include a separate buffer zone (an extra isolator compartment) that is designed to exhaust both incoming room air and outgoing positive pressure air from the main workstation. The main workstation isolator, in which the sterile product is exposed, is therefore protected from contaminated air and the toxic product is exhausted via the buffer zone before it reaches operators working outside of the isolation.
While the positive pressure isolator is most common, "negative" pressure devices also exist for very large industrial operations that handle toxic products. The "negative pressure isolator," and has become less common and desirable, but is superior to the traditional biosafety cabinet which is vulnerable to contamination and can expose the worker to toxicological hazards if not operated properly. A simpler and more effective option for nearly all toxicological containment applications is the use of "closed isolator" design , which is maintained under positive pressure (this is the most appropriate containment option unless a company processes thousands of units per minute). If a negative isolator is used, its intricate design must fulfill two objectives: protect workers outside of the isolator, and assure sterility of sterile drugs inside the isolator. As such, the term "negative pressure" isolator is somewhat of a misnomer, as contaminated ("polluted") room air must not be pulled into the main workstation isolator in a sterile operation. Thus, the actual workstation isolator is always maintained under substantial positive pressure. The "negative" pressure isolator does however include a separate buffer zone (an extra isolator compartment) that is designed to exhaust both incoming room air and outgoing positive pressure air from the main workstation. The main workstation isolator, in which the sterile product is exposed, is therefore protected from contaminated air as the toxic product should be exhausted via the buffer zone before it reaches operators working outside of the isolation.
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The "negative pressure isolator," and has become less common and desirable, but is superior to the traditional biosafety cabinet which is vulnerable to contamination and can expose the worker to toxicological hazards if not operated properly.
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