Research to compare antibiotic treatments currently recommended in consensus guidelines identified 44 studies comparing different antibiotics. Significantly higher mortality was reported for Cefepime compared to all other antibiotics combined. Piperacillin ‐ tazobactam resulted in lower mortality than other antibiotics. Piperacillin ‐ tazobactam might be the preferred antibiotic for the treatment of cancer patients with fever and neutropenia, while cefepime should not be used. In people with cancer who have febrile neutropoenia (excluding patients with acute leukaemia), oral treatment is an acceptable alternative to intravenous antibiotic treatment if they are haemodynamically stable, without organ failure, without pneumonia and with no infection of a central line or severe soft-tissue infection. Furthermore, outpatient treatment for low‐risk febrile neutropaenia in people with cancer probably makes little or no difference to treatment failure and mortality compared with the standard hospital (inpatient) treatment and may reduce time that patients need to be treated in hospital.
Research to compare antibiotic treatments currently recommended in consensus guidelines identified 44 studies comparing different antibiotics. Significantly higher mortality was reported for cefepime compared to all other antibiotics combined. Piperacillin / tazobactam resulted in lower mortality than other antibiotics. Piperacillin / tazobactam might be the preferred antibiotic for the treatment of cancer patients with fever and neutropenia, while cefepime should not be used. In people with cancer who have febrile neutropenia (excluding patients with acute leukaemia), oral treatment is an acceptable alternative to intravenous antibiotic treatment if they are hemodynamically stable, without organ failure, without pneumonia and with no infection of a central line or severe soft-tissue infection. Furthermore, outpatient treatment for low‐risk febrile neutropenia in people with cancer probably makes little or no difference to treatment failure and mortality compared with the standard hospital (inpatient) treatment and may reduce time that patients need to be treated in hospital.
R
Cefepime
cefepime
R
‐
/
R
‐
/
R
neutropoenia
neutropenia
R
haemodynamically
hemodynamically
R
neutropaenia
neutropenia