After 1958, Tsou was a member of the team at the Shanghai Institute of Biochemistry that first achieved the total chemical synthesis of insulin in 1965. His major contribution to the project was to form the disulphate bridges by joining two synthetic polypeptides using oxidation. His method for calculating the chemical modification of proteins is known as Tsou's equation . In 1981, he was awarded the State Natural Science Award, First Class, for this achievement.
After 1958, Tsou was a member of the team at the Shanghai Institute of Biochemistry that first achieved the total chemical synthesis of insulin in 1965. His major contribution to the project was to form the disulphate bridges by joining two synthetic polypeptides using oxidation. His method for estimating the number of essential amino acid residues in an enzyme by chemical modification, in which the remaining activity is plotted against the number of residues modified is known as the Tsou plot . In 1981, he was awarded the State Natural Science Award, First Class, for this achievement.
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calculating the chemical modification of proteins
estimating the number of essential amino acid residues in an enzyme by chemical modification, in which the remaining activity is plotted against the number of residues modified
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Tsou's equation
the Tsou plot