As the most widely used antimalarial agent, chloroquine (CQ) has been used  for more than half century. However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis  our published experimental results, we propose that the mechanism of CQ action and resistance might be closely linked with cell-cycle-associated amplified genomic-DNA fragments (CAGFs, singular form = CAGF) as CQ induces CAGF production in P. falciparum, which could affect multiple biological processes of the parasite, and thus might contribute to parasite death and CQ resistance. Recently, we found that CQ induced one of CAGFs, UB1- CAGF, might downregulate a probable P. falciparum cystine transporter (Pfct) gene expression, which could be used to understand the mechanism of CQ action and resistance in P. falciparum.
As a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century. However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis of our published experimental results, we propose that the mechanism of CQ action and resistance might be closely linked with cell-cycle-associated amplified genomic-DNA fragments (CAGFs, singular form = CAGF) as CQ induces CAGF production in P. falciparum, which could affect multiple biological processes of the parasite, and thus might contribute to parasite death and CQ resistance. Recently, we found that CQ induced one of CAGFs, UB1- CAGF, might downregulate a probable P. falciparum cystine transporter (Pfct) gene expression, which could be used to understand the mechanism of CQ action and resistance in P. falciparum.
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the most widely used
a cheap and safe
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in the battle against malaria
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