Splay is a physiological term that refers to the difference between urine threshold (the amount of a substance required in the kidneys before it appears in the urine) and saturation, or TM ; in this instance, saturation refers to an exhausted supply of renal reabsorption carriers. In simpler terms, splay is the concentration difference between a substance's maximum renal reabsorption vs. appearance in the urine. Splay is usually used in reference to glucose; other substances, such as phosphate, have virtually no splay at all. Splay appears to occur because kidney nephrons do not have the same tubular maximum for glucose (TmG) therefore some nephrons may excrete before others and also because "the maximum reabsorption rate (or Tm) cannot be achieved until the amount/min of glucose being presented to the renal tubules is great enough to fully saturate the receptor sites". John Field of the American Physiological Society said "Since the splay may occur when the residual nephrons are said to be free of anatomic abnormalities, the possibility exists that changes in the kinetics of glucose reabsorption may have been induced".Field, John, Handbook of Physiology: Renal physiology, page 598, American Physiological Society
In physiology, splay is the difference between urine threshold (the amount of a substance required in the kidneys before it appears in the urine) and saturation, or TM , where saturation is the exhausted supply of renal reabsorption carriers. In simpler terms, splay is the concentration difference between a substance's maximum renal reabsorption vs. appearance in the urine. Splay is usually used in reference to glucose; other substances, such as phosphate, have virtually no splay at all. Splay appears to occur because kidney nephrons do not have the same tubular maximum for glucose (TmG) therefore some nephrons may excrete before others and also because "the maximum reabsorption rate (or Tm) cannot be achieved until the amount/min of glucose being presented to the renal tubules is great enough to fully saturate the receptor sites". John Field of the American Physiological Society said "Since the splay may occur when the residual nephrons are said to be free of anatomic abnormalities, the possibility exists that changes in the kinetics of glucose reabsorption may have been induced".Field, John, Handbook of Physiology: Renal physiology, page 598, American Physiological Society
R
Splay is a physiological term that refers to
In physiology, splay is
R
; in this instance, saturation refers to an
, where saturation is the