In his 2005 article, Wild stated, "At its most complete, the exposome encompasses life-course environmental exposures (including lifestyle factors), from the prenatal period onwards." The concept was first proposed to draw attention to the need for better and more complete environmental exposure data for causal research, in order to balance the investment in genetics. According to Wild, even incomplete versions of the exposome could be useful to epidemiology. In 2012, Wild outlined methods, including personal sensors, biomarkers, and 'omics' technologies, to better define the exposome. He described three overlapping domains within the exposome: a general external environment including the urban environment, education, climate factors, social capital, stress, a specific external environment with specific contaminants, radiation, infections, lifestyle factors (e.g. tobacco, alcohol), diet, physical activity, etc. an internal environment to include internal biological factors such as metabolic factors, hormones, gut microflora, inflammation, oxidative stress. In late 2013, this definition was explained in greater depth in the first book on the exposome. In 2014, the same author revised the definition to include the body's response with its endogenous metabolic processes which alter the processing of chemicals. Evidence by metabolic exposures in and around the time of pregnancy  the maternal metabolic exposome  includes exposures such as maternal obesity/overweight and diabetes, and malnutrition, including high fat/high calorie diets, are associated with poor fetal, infant and child growth Wang, J., et al., 2019. Gestational diabetes and offspring’s growth from birth to 6 years old. Int. J. Obes. 43, 663–672, and increased incidence of obesity and other metabolic disorders in later life Wang , J., et al., 2019. Gestational diabetes and offspring’s growth from birth to 6 years old. Int. J.Obes. 43, 663–672. 
In his 2005 article, Wild stated, "At its most complete, the exposome encompasses life-course environmental exposures (including lifestyle factors), from the prenatal period onwards." The concept was first proposed to draw attention to the need for better and more complete environmental exposure data for causal research, in order to balance the investment in genetics. According to Wild, even incomplete versions of the exposome could be useful to epidemiology. In 2012, Wild outlined methods, including personal sensors, biomarkers, and 'omics' technologies, to better define the exposome. He described three overlapping domains within the exposome: a general external environment including the urban environment, education, climate factors, social capital, stress, a specific external environment with specific contaminants, radiation, infections, lifestyle factors (e.g. tobacco, alcohol), diet, physical activity, etc. an internal environment to include internal biological factors such as metabolic factors, hormones, gut microflora, inflammation, oxidative stress. In late 2013, this definition was explained in greater depth in the first book on the exposome. In 2014, the same author revised the definition to include the body's response with its endogenous metabolic processes which alter the processing of chemicals. Evidenced by metabolic exposures in and around the time of pregnancy , the maternal metabolic exposomeStrain, J., Spaans, F., Serhan, M., Davidge, S. T. Connor, K. L.. Programming of weight and obesity across the lifecourse by the maternal metabolic exposome: A systematic review. Molecular Aspects of Medicine 100986 (2021). doi:10.1016/j.mam.2021.100986 includes exposures such as maternal obesity/overweight and diabetes, and malnutrition, including high fat/high calorie diets, are associated with poor fetal, infant and child growth Wang, J., et al., 2019. Gestational diabetes and offspring’s growth from birth to 6 years old. Int. J. Obes. 43, 663–672, and increased incidence of obesity and other metabolic disorders in later life Strain , J., Spaans, F., Serhan, M., Davidge, S. T. Connor, K. L.. Programming of weight and obesity across the lifecourse by the maternal metabolic exposome: A systematic review. Molecular Aspects of Medicine 100986 (2021). doi:10.1016/j.mam.2021.100986.
R
Evidence
Evidenced
A
,
R
exposome
exposomeStrain, J., Spaans, F., Serhan, M., Davidge, S. T.
A
Connor, K. L.. Programming of weight and obesity across the lifecourse by the maternal metabolic exposome: A systematic review. Molecular Aspects of Medicine 100986 (2021). doi:10.1016/j.mam.2021.100986
R
Wang
Strain
R
et al., 2019. Gestational diabetes and offspring’s growth from birth to 6 years old. Int. J.Obes. 43, 663–672.
Spaans, F., Serhan, M., Davidge, S. T.
A
Connor, K. L.. Programming of weight and obesity across the lifecourse by the maternal metabolic exposome: A systematic review. Molecular Aspects of Medicine 100986 (2021). doi:10.1016/j.mam.2021.100986.