The Influenza A virus belongs to the Orthomyxoviridae family. Influenza virus infection occurs yearly in all countries of the world. It usually kills between 250,000 and 500,000 people and causes severe illness in millions more. Over the last century alone we have seen 3 global influenza pandemics. The great human and financial cost of this disease has made it the second most studied virus today, behind HIV. Recently, several genome-wide RNA interference studies have focused on identifying host molecules that participate in Influenza infection. We used five of these studies for this meta-analysis.  As a result, 2 host gene complexes important for the Influenza virus life cycle were identified. The first complex is related to Golgi transport and vesicle coating. Several viral proteins go through this complex before viral budding, the knock-down of Golgi related proteins might have prevented viral production. The second complex is related to ATP dependent proton transport. The uncoating of the  Influenza virus is dependent on pH changes within the endosome, knock-down of these genes may changes in the endosomal pH inhibiting the uncoating of the virus .
The Influenza A virus belongs to the Orthomyxoviridae family. Influenza virus infection occurs yearly in all countries of the world. It usually kills between 250,000 and 500,000 people and causes severe illness in millions more. Over the last century alone we have seen 3 global influenza pandemics. The great human and financial cost of this disease has made it the second most studied virus today, behind HIV. Recently, several genome-wide RNA interference studies have focused on identifying host molecules that participate in Influenza infection. We used nine of these studies for this meta-analysis. Even though the overlap among genes identified in multiple screens was small, network analysis indicates that similar protein complexes and biological functions of the host were present. As a result, several host gene complexes important for the Influenza virus life cycle were identified. The biological function and the relevance of each identified protein complex in the Influenza virus life cycle is further detailed in this paper .
R
five
nine
A
Even though the overlap among genes identified in multiple screens was small, network analysis indicates that similar protein complexes and biological functions of the host were present.
R
2
several
R
first complex is related to Golgi transport and vesicle coating. Several viral proteins go through this complex before viral budding, the knock-down of Golgi related proteins might have prevented viral production. The second complex is related to ATP dependent proton transport. The uncoating of
biological function and
A
relevance of each identified protein complex in the
R
is dependent on pH changes within the endosome, knock-down of these genes may changes in the endosomal pH inhibiting the uncoating of the virus
life cycle is further detailed in this paper