Molecular motors are nonequilibrium open systems that convert chemical energy to mechanical work. Here we investigate the nonequilibrium energetics of a single molecule kinesin by measuring the motion of an attached probe particle and its response to external forces with optical tweezers. The sum of the heat dissipation estimated from the violation of the fluctuation-response relation and the output power was inconsistent with the input free energy rate, implying that internal dissipation is dominant. By using a two-state Markov model, we discuss the energy flow of the kinesin motor .
Nonequilibrium energetics of single molecule translational motor kinesin was investigated by measuring heat dissipation from the violation of the fluctuation-response relation of a probe attached to the motor using optical tweezers. The sum of the dissipation and work did not amount to the input free energy change, indicating large hidden dissipation exists. Possible sources of the hidden dissipation were explored by analyzing the Langevin dynamics of the probe, which incorporates the two-state Markov stepper as a kinesin model. We conclude that internal dissipation is dominant .
R
Molecular motors are nonequilibrium open systems that convert chemical energy to mechanical work. Here we investigate the nonequilibrium energetics of a single molecule kinesin by measuring
Nonequilibrium energetics of single molecule translational motor kinesin was investigated by measuring heat dissipation from the violation of
R
motion of an attached probe particle and its response to external forces with
fluctuation-response relation of a probe attached to the motor using
R
heat dissipation estimated from the violation of the fluctuation-response relation and the output power was inconsistent with the
dissipation and work did not amount to the
R
rate, implying that internal dissipation is dominant. By using a
change, indicating large hidden dissipation exists. Possible sources of the hidden dissipation were explored by analyzing the Langevin dynamics of the probe, which incorporates the
R
Markov model, we discuss the energy flow of the kinesin motor
Markov stepper as a kinesin model. We conclude that internal dissipation is dominant