Anatomical location Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include: Micrograph showing cirrhosis of the liver. The tissue in this example is stained with a trichrome stain, in which fibrosis is colored blue. The red areas are the nodular liver tissue Lungs Fibrothorax Pulmonary fibrosis Cystic fibrosis Idiopathic pulmonary fibrosis (idiopathic meaning the cause is unknown) Radiation-induced lung injury (following treatment for cancer) Liver Bridging fibrosis An advanced stage of liver fibrosis seen in the progressive form of chronic liver diseases. The term “bridging” means ‘the formation of “bridge” (by the band of mature & thick fibrous tissue) obliterating portal area to central vein’, leads to the formation of pseudolobules. The long term exposure of hepatotoxin (like thioacetamide, carbon tetrachloride, diethylnitrosamine , etc. ) results in the bridging fibrosis in experimental animal models.
Anatomical location Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include: Micrograph showing cirrhosis of the liver. The tissue in this example is stained with a trichrome stain, in which fibrosis is colored blue. The red areas are the nodular liver tissue Lungs Fibrothorax Pulmonary fibrosis Cystic fibrosis Idiopathic pulmonary fibrosis (idiopathic meaning the cause is unknown) Radiation-induced lung injury (following treatment for cancer) Liver Bridging fibrosis An advanced stage of liver fibrosis seen in the progressive form of chronic liver diseases. The term “bridging” means ‘the formation of “bridge” (by the band of mature & thick fibrous tissue) obliterating portal area to central vein’, leads to the formation of pseudolobules. Long-term exposure to hepatotoxin (e.g. thioacetamide, carbon tetrachloride, diethylnitrosamine ) results in the bridging fibrosis in experimental animal models.
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