400px |Chemical formulae of ethyl linoleate — natural and its deuterated version 11,11-D2-ethyl linoleate (RT001). Hydrogen atoms are explicitly shown where they are replaced with deuterium atoms. iFood (isotopic food) contains nutrients in which some atoms are replaced with their heavier non-radioactive isotopes, such as deuterium 2H or heavy carbon 13C. Biomolecules that incorporate heavier isotopes give rise to more stable molecular structures with increased resistance to damages associated with URL or diseases. Medicines with some hydrogen atoms substituted with deuterium are called deuterated drugs, while substances that are essential nutrients can be used as food constituents, making this food "isotopic". Consumed with food, these nutrients become building material for the body. The examples are deuterated polyunsaturated fatty acids (iFat) , essential aminoacids, DNA bases such as cytosine, or heavy water and glucose. Mechanism of protective effect One of the most pernicious and irreparable types of oxidative damage inflicted by reactive oxygen species (ROS) upon biomolecules involves the carbon-hydrogen bond cleavage (hydrogen abstraction). Intriguingly, the biomolecules most damageable by this type of damage belong to the group of essential nutrients (10 out of 20 amino acids; nucleosides at certain conditions (conditionally essential); all polyunsaturated fatty acids). In theory, replacing hydrogen with deuterium "reinforces" the bond due to the kinetic isotope effect, and such reinforced biomolecules taken up by the body will be more resistant to ROS. Deuterated omega-6 fatty acids for humans with degenerative diseases The company Retrotope pioneered the development a source of deuterated omega-6 fatty acid di-deuterated linoleic acid ethyl ester (RT001) as a food additive for potential treatment of neurodegenerative diseases such as Friedreich’s ataxia and infantile neuroaxonal dystrophy. FDA has granted it an orphan drug designation and it passed the Phase I/II clinical trials (as of 2018). The difference from the treatment with heavy water After publication in scientific literature, the concept of isotopic food moved on to popular science publicationsEat isotopes to live longer Gross M. 22 March 2007. Chemistry World. and even became a hot topic in mass media where the anti-ageing properties were often mistakenly attributed to heavy URL
278x278px |Chemical formulae of ethyl linoleate — natural and its deuterated version 11,11-D2-ethyl linoleate (RT001). Hydrogen atoms are explicitly shown where they are replaced with deuterium atoms. A heavy isotope diet is one in that contains nutrients in which some atoms are replaced with their heavier non-radioactive isotopes, such as deuterium 2H or heavy carbon 13C. Biomolecules that incorporate heavier isotopes give rise to more stable molecular structures , which is hypothesized to increase resistance to damage associated with URL or diseases. Medicines with some hydrogen atoms substituted with deuterium are called deuterated drugs, while substances that are essential nutrients can be used as food constituents, making this food "isotopic". Consumed with food, these nutrients become building material for the body. The examples are deuterated polyunsaturated fatty acids , essential aminoacids, DNA bases such as cytosine, or heavy water and glucose. Suggested mechanism One of the most pernicious and irreparable types of oxidative damage inflicted by reactive oxygen species (ROS) upon biomolecules involves the carbon-hydrogen bond cleavage (hydrogen abstraction). Intriguingly, the biomolecules most damageable by this type of damage belong to the group of essential nutrients (10 out of 20 amino acids; nucleosides at certain conditions (conditionally essential); all polyunsaturated fatty acids). In theory, replacing hydrogen with deuterium "reinforces" the bond due to the kinetic isotope effect, and such reinforced biomolecules taken up by the body will be more resistant to ROS. Deuterated omega-6 fatty acids for humans with degenerative diseases The company Retrotope pioneered the development a source of deuterated omega-6 fatty acid di-deuterated linoleic acid ethyl ester (RT001) as a food additive for potential treatment of neurodegenerative diseases such as Friedreich’s ataxia and infantile neuroaxonal dystrophy. FDA has granted it an orphan drug designation and it passed the Phase I/II clinical trials (as of 2018). 
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iFood (isotopic food)
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with increased resistance to damages
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Mechanism of protective effect
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The difference from the treatment with heavy water After publication in scientific literature, the concept of isotopic food moved on to popular science publicationsEat isotopes to live longer Gross M. 22 March 2007. Chemistry World. and even became a hot topic in mass media where the anti-ageing properties were often mistakenly attributed to heavy URL