Targeted intra-operative radiotherapy, also known as targeted IORT or TARGIT (TARGeted Intraoperative radioTherapy) is a technique of giving radiotherapy to the tissues surrounding a cancer after its surgical removal, a form of intraoperative radiation therapy. The technique was designed in 1998 at the University College London. In patients having lumpectomy for breast cancer, the TARGIT-A(lone) randomized controlled trial (recruitment from 2000–2012) tested whether TARGIT within a risk-adapted approach is non-inferior to conventional course of external beam postoperative radiotherapy given over several weeks. TARGIT is a method where the radiation is applied during an operation and targeted to the peri-tumoural tissues. TARGIT technique was designed at University College London by Jayant S Vaidya (who coined the TARGIT acronym) and Michael Baum along with Jeffrey S Tobias in 1998. The term was first used when the technique was described, and the protocol for a randomised trial was published by The Lancet. Technique TARGeted Intraoperative radioTherapy (TARGIT) IORT for breast cancer The machine used for TARGIT is Intrabeam (Carl Zeiss , Germany) . It is a miniature and mobile X-ray source which emits low energy X-ray radiation (max. 50 kV) in isotropic distribution. Due to the higher ionization density caused by soft X-ray radiation in the tissue, the relative biological effectiveness (RBE) of low-energy X-rays on tumour cells is higher when compared to high-energy X-rays or gamma rays which are delivered by linear accelerators. The radiation which is produced by mobile radiation systems has a limited range . For this reason, conventional walls are regarded sufficient to stop the radiation scatter produced in the operating room and no extra measures for radiation protection are necessary. This makes IORT for breast cancer by the TARGIT technique available in most operating rooms. The surgical technique is relatively simple but needs to be meticulously followed .
Targeted intra-operative radiotherapy, also known as targeted IORT is a technique of giving radiotherapy to the tissues surrounding a cancer after its surgical removal, a form of intraoperative radiation therapy. The technique was designed in 1998 at the University College London. In patients having lumpectomy for breast cancer, the TARGIT-A(lone) randomized controlled trial (recruitment from 2000–2012) tested whether TARGIT within a risk-adapted approach is non-inferior to conventional course of external beam postoperative radiotherapy given over several weeks. One IORT technique is known as TARGIT (TARGeted Intraoperative radioTherapy). TARGIT is a method where the radiation is applied during an operation and targeted to the peri-tumoural tissues. TARGIT technique was designed at University College London by Jayant S Vaidya (who coined the TARGIT acronym) and Michael Baum along with Jeffrey S Tobias in 1998. The term was first used when the technique was described, and the protocol for a randomised trial was published by The Lancet. Technique The Intrabeam system, manufactured by Carl Zeiss AG, is used for TARGIT . It is a miniature and mobile X-ray source which emits low energy X-ray radiation (max. 50 kV) in isotropic distribution. Due to the higher ionisation density caused by soft X-ray radiation in the tissue, the relative biological effectiveness (RBE) of low-energy X-rays on tumour cells is higher when compared to high-energy X-rays or gamma rays which are delivered by linear accelerators. Lower energy radiation such as this has a limited range , and therefore conventional walls may be sufficient to stop the radiation scatter produced in the operating room without extra measures for radiation protection .
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One IORT technique is known as TARGIT (TARGeted Intraoperative radioTherapy). TARGIT
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TARGeted Intraoperative radioTherapy (TARGIT) IORT for breast cancer The machine used for TARGIT is Intrabeam (Carl Zeiss , Germany)
The Intrabeam system, manufactured by Carl Zeiss AG, is used for TARGIT
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are necessary. This makes IORT for breast cancer by the TARGIT technique available in most operating rooms. The surgical technique is relatively simple but needs to be meticulously followed