Many biological activities are induced by cellular chemical reactions of diffusing reactants. The dynamics of such systems can be captured by stochastic reaction networks. A recent numerical study has shown that diffusion can significantly enhance the fluctuations in gene regulatory networks. However, the general relation between diffusion and stochastic system dynamics remains unveiled. Here we examine the general relation and find the universal law under which the steady-state distribution in complex balanced networks is diffusion-independent. Here, complex balance is the non-equilibrium generalization of detailed balance. We also find that for a diffusion-included network with a Poisson-like steady-state distribution, the diffusion can be ignored at steady-state . We then derive a necessary and sufficient condition for  such steady-state network distributions. Moreover, we exactly prove that the stochastic dynamics of linear reaction networks are unaffected by diffusion at any arbitrary time. Our findings shed light on the fundamental question of when diffusion can be neglected, or (if non-negligible ) its effects on the stochastic dynamics of the reaction network.
Many biological activities are induced by cellular chemical reactions of diffusing reactants. The dynamics of such systems can be captured by stochastic reaction networks. A recent numerical study has shown that diffusion can significantly enhance the fluctuations in gene regulatory networks. However, the universal relation between diffusion and stochastic system dynamics remains veiled. Within the approximation of reaction-diffusion master equation (RDME), we find general relation that the steady-state distribution in complex balanced networks is diffusion-independent. Here, complex balance is the nonequilibrium generalization of detailed balance. We also find that for a diffusion-included network with a Poisson-like steady-state distribution, the diffusion can be ignored at steady state . We then derive a necessary and sufficient condition for networks holding such steady-state distributions. Moreover, we show that for linear reaction networks the RDME reduces to the chemical master equation, which implies that the stochastic dynamics of networks is unaffected by diffusion at any arbitrary time. Our findings shed light on the fundamental question of when diffusion can be neglected, or (if nonnegligible ) its effects on the stochastic dynamics of the reaction network.
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