It is now well accepted that cellular responses to materials in a biological medium reflect greatly the adsorbed biomolecular layer, rather than the material itself. Here, we study by molecular dynamic simulations the competitive protein adsorption on a surface ( Vroman-like effect), i.e. the non-monotonic behavior of the amount of protein adsorbed on a surface in contact with plasma as a function of contact time and plasma concentration  . We show how the effect can be understood, controlled and inverted.
It is now well accepted that cellular responses to materials in a biological medium reflect greatly the adsorbed biomolecular layer, rather than the material itself. Here, we study by molecular dynamic simulations the competitive protein adsorption on a surface ( Vroman effect), i.e. the non-monotonic behavior of the amount of protein adsorbed on a surface in contact with plasma as a function of contact time and plasma concentration . We find a complex behavior, with regimes during which small and large proteins are not necessarily competing between them, but are both competing with others in solution . We show how the effect can be understood, controlled and inverted.
R
Vroman-like
Vroman
A
. We find a complex behavior, with regimes during which small and large proteins are not necessarily competing between them, but are both competing with others in solution