Cambridge After only two years, Leloir received recognition from the medical department at UBA for having produced the best doctoral thesis. Feeling that his knowledge in fields such as physics, mathematics, chemistry, and biology was lacking, he continued attending classes at the University as a part-time student. In 1936 he traveled to England to begin advanced studies at the University of Cambridge, under the supervision of another Nobel Prize winner, Sir Frederick Gowland Hopkins, who had obtained that distinction in 1929 for his work in physiology and in revealing the critical role of vitamins in maintaining good health. Leloir's research in the Biochemical Laboratory of Cambridge centered around enzymes, more specifically the effects of cyanide and pyrophosphate on succinic dehydrogenase; from this moment Leloir began to specialize in researching carbohydrate metabolism. By 1947 he had formed a team that included  Caputto, Enrico Cabib, Raúl Trucco, Alejandro Paladini, Carlos Cardini and José Luis Reissig, with whom he investigated and discovered why a malfunctioning kidney and angiotensin helped cause hypertension."The Substance Causing Renal Hypertension"(E. Braun-Menedez, J.C. Fasciolo, L.F. Leloir, J.M. Muñoz)The Journal of Physiology(1940) no.98 pg.283-298 That same year, his colleague Ranwel Caputto, in his investigations of the mammary gland, made discoveries regarding carbohydrate storage and its subsequent transformation into a reserve energy form in organisms. Sugar nucleotides Chemical structure of galactose. Leloir and his team discovered that in galactosemia, patients lacked the necessary enzyme (Galactose-1-phosphate uridylyltransferase) to convert unusable galactose into usable glucose. At the beginning of 1948, Leloir and his team identified the sugar nucleotides that were fundamental to the metabolism of carbohydrates, turning the Instituto Campomar into a biochemistry institution well known throughout the world. Immediately thereafter, Leloir received the Argentine Scientific Society Prize, one of the many awards he would receive both in Argentina and internationally. During this time, his team dedicated itself to the study of glycoproteins; Leloir and his colleagues elucidated the primary mechanisms of galactose metabolism (now coined the Leloir pathwayHolton JB, Walter JH, and Tyfield LA. "Galactosemia" in The Metabolic and Molecular Bases of Inherited Disease, 8th edition, 2001. Scriver, Beaudet, et al., McGraw-Hill, vol I, chapter 72, p.1553-1587.) and determined the cause of galactosemia, a serious genetic disorder that resulted in lactose intolerance. The following year, he reached an agreement with Rolando García, dean of the Faculty of Exact and Natural Sciences at UBA , which named Leloir, Carlos Eugenio Cardini and Enrico Cabib as titular professors in the University's newly founded Biochemical Institute. The Institute would help develop scientific programs in budding Argentine universities as well as attract researchers and scholars from the United States, Japan, England, France, Spain, and other Latin American countries. Following  Campomar's death in 1957, Leloir and his team applied to the National Institutes of Health in the United States desperate for funding, and surprisingly was accepted. In 1958, the Institute found a new home in a former all-girls school, a donation from the Argentine government. As Leloir and his research gained greater prominence, further research came from the Argentine Research Council, and the Institute would later become associated with the University of Buenos Aires.World of Scientific Discovery, Thomas Gale, Thomson Corporation, 2005-2006 Later years Leloir  celebrating with colleagues December 10, 1970, after winning the Nobel Prize. As his work in the laboratory was coming to an end, Leloir continued his teaching position in the Department of Natural Sciences at the University of Buenos Aires, taking a hiatus only to complete his studies at Cambridge and at the Enzyme Research Laboratory in the United States. Published works Bibliography Lorenzano, Julio César. Por los caminos de Leloir. Editorial Biblos; 1a edition, July 1994. ISBN 9-5078-6063-0 Zuberbuhler de Leloir, Amelia. Retrato personal de Leloir. Vol. 8, No. 25, pp. 45-46, 1983. Nachón, Carlos Alberto. Luis Federico Leloir: ensayo de una biografía. Bank Foundation of Boston, 1994. External links Fundación Instituto Leloir The Official Site of Louisa Gross Horwitz Prize
Cambridge After only two years, Leloir received recognition from the medical department at the University of Buenos Aires for having produced the best doctoral thesis. Feeling that his knowledge in fields such as physics, mathematics, chemistry, and biology was lacking, he continued attending classes at the University as a part-time student. In 1936 he traveled to England to begin advanced studies at the University of Cambridge, under the supervision of another Nobel Prize winner, Sir Frederick Gowland Hopkins, who had obtained that distinction in 1929 for his work in physiology and in revealing the critical role of vitamins in maintaining good health. Leloir's research in the Biochemical Laboratory of Cambridge centered around enzymes, more specifically the effects of cyanide and pyrophosphate on succinic dehydrogenase; from this moment Leloir began to specialize in researching carbohydrate metabolism. By 1947 he had formed a team that included Ranwel Caputto, Enrico Cabib, Raúl Trucco, Alejandro Paladini, Carlos Cardini and José Luis Reissig, with whom he investigated and discovered why a malfunctioning kidney and angiotensin helped cause hypertension."The Substance Causing Renal Hypertension"(E. Braun-Menedez, J.C. Fasciolo, L.F. Leloir, J.M. Muñoz)The Journal of Physiology(1940) no.98 pg.283-298 That same year, his colleague Caputto, in his investigations of the mammary gland, made discoveries regarding carbohydrate storage and its subsequent transformation into a reserve energy form in organisms. Sugar nucleotides Chemical structure of galactose. Leloir and his team discovered that in galactosemia, patients lacked the necessary enzyme (Galactose-1-phosphate uridylyltransferase) to convert unusable galactose into usable glucose. At the beginning of 1948, Leloir and his team identified the sugar nucleotides that were fundamental to the metabolism of carbohydrates, turning the Instituto Campomar into a biochemistry institution well known throughout the world. Immediately thereafter, Leloir received the Argentine Scientific Society Prize, one of the many awards he would receive both in Argentina and internationally. During this time, his team dedicated itself to the study of glycoproteins; Leloir and his colleagues elucidated the primary mechanisms of galactose metabolism (now called the Leloir pathwayHolton JB, Walter JH, and Tyfield LA. "Galactosemia" in The Metabolic and Molecular Bases of Inherited Disease, 8th edition, 2001. Scriver, Beaudet, et al., McGraw-Hill, vol I, chapter 72, p.1553-1587.) and determined the cause of galactosemia, a serious genetic disorder that resulted in lactose intolerance. The following year, he reached an agreement with Rolando García, dean of the Faculty of Exact and Natural Sciences at the University of Buenos Aires , which named Leloir, Carlos Eugenio Cardini and Enrico Cabib as titular professors in the University's newly founded Biochemical Institute. The Institute would help develop scientific programs in budding Argentine universities as well as attract researchers and scholars from the United States, Japan, England, France, Spain, and other Latin American countries. Following Jaime Campomar's death in 1957, Leloir and his team applied to the National Institutes of Health in the United States desperate for funding, and surprisingly was accepted. In 1958, the Institute found a new home in a former all-girls school, a donation from the Argentine government. As Leloir and his research gained greater prominence, further research came from the Argentine Research Council, and the Institute would later become associated with the University of Buenos Aires.World of Scientific Discovery, Thomas Gale, Thomson Corporation, 2005-2006 Later years In his later years Leloir continued to study glycogen and other aspects of carbohydrate metabolism. Leloir celebrating with colleagues December 10, 1970, after winning the Nobel Prize. As his work in the laboratory was coming to an end, Leloir continued his teaching position in the Department of Natural Sciences at the University of Buenos Aires, taking a hiatus only to complete his studies at Cambridge and at the Enzyme Research Laboratory in the United States. Bibliography Lorenzano, Julio César. Por los caminos de Leloir. Editorial Biblos; 1a edition, July 1994. ISBN 9-5078-6063-0 Zuberbuhler de Leloir, Amelia. Retrato personal de Leloir. Vol. 8, No. 25, pp. 45-46, 1983. Nachón, Carlos Alberto. Luis Federico Leloir: ensayo de una biografía. Bank Foundation of Boston, 1994. External links Fundación Instituto Leloir The Official Site of Louisa Gross Horwitz Prize
R
UBA
the University of Buenos Aires
A
Ranwel
D
Ranwel
R
(now coined
(now called
R
UBA
the University of Buenos Aires
A
Jaime
R
Leloir
In his later years Leloir continued to study glycogen
A
and other aspects of carbohydrate metabolism. Leloir
D
Published works