The effect of an oscillating electric field generated from music on yeast vacuolar proton-ATPase ( V-ATPase ) activity in its native environment is reported. An oscillating electric field is generated from audio clips of music spanning various genres and played to electrodes that are immersed into a dispersion of yeast vacuolar membrane vesicles natively hosting a high concentration of active V-ATPase . The substantial difference in the ATP hydrolysing activity of V-ATPase under the most stimulating and inhibiting music is unprecedented. Good correlation is found between changes in ATPase activity of the enzyme and the combined intensity of certain frequency bands of the Fourier spectra of the music clips. Most prominent identified frequencies are harmonically related to each other and to the estimated rotation rate of the enzyme  .
The effect of an oscillating electric field generated from music on yeast vacuolar proton-ATPase ( V- ATPase ) activity in its native environment is reported. An oscillating electric field is generated from audio clips of music spanning various genres and played to electrodes that are immersed into a dispersion of yeast vacuolar membrane vesicles natively hosting a high concentration of active V- ATPase . The substantial difference in the ATP hydrolysing activity of V-ATPase under the most stimulating and inhibiting music is unprecedented. Good correlation is found between changes in the specific activity of the enzyme and the combined intensity of certain frequency bands of the Fourier spectra of the music clips. Most prominent identified frequencies are harmonically related to each other and to the estimated rotation rate of the enzyme . Under the given experimental conditions, the top four music clips that most enhance the specific activity of V-ATPase are in the musical key of D, in a perfect agreement with the Fourier analysis of the clips .
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. Under the given experimental conditions, the top four music clips that most enhance the specific activity of V-ATPase are in the musical key of D, in a perfect agreement with the Fourier analysis of the clips