Based on data on gene expression profiles from microarrays for E. Coli and tumor tissues, I show the existence of heavy tails in the gene expression distribution functions, related to a set of strongly over- and under-expressed genes . The tails are heavier -- i.e. the fraction of genes and the expression levels are much higher (lower) -- in tumors than in bacteria , presumably due to epigenetic factors . Different tissue tumors show remarkably similar tails, indicating a kind of universality in cancer phenomena.
Based on data on gene expression profiles from microarrays for E. Coli and tumor tissues, I show that the evolution for thousands of generations leads to a set of strongly over- and under-expressed genes , as compared to the initial expression profile. This fact is manifested as heavy tails in the gene expression distribution functions. The tails are heavier -- i.e. the fraction of genes and the expression levels vary much more -- in tumors than in bacteria . Different tissue tumors show remarkably similar tails, indicating a kind of universality in cancer phenomena.
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the existence of heavy tails in the gene expression distribution functions, related
that the evolution for thousands of generations leads
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, as compared to the initial expression profile. This fact is manifested as heavy tails in the gene expression distribution functions.
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are much higher (lower)
vary much more
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, presumably due to epigenetic factors