Clozapine N-oxide (CNO) is a synthetic drug used mainly in biomedical research as a ligand to activate DREADD receptors. Although CNO was initially believed to be biologically inert  , it has been shown to reverse metabolise into clozapine which has a series of effects on  serotonin and dopamine receptors. Alternatives to CNO with more inert character and faster kinetics include Compound 21 (C21) and deschloroclozapine (DCZ).
Clozapine N-oxide (CNO) is a synthetic drug used mainly in biomedical research as a ligand to activate DREADD receptors. Although CNO was initially believed to be biologically inert and an agonist of DREADDs , it has been shown not to enter the brain after administration and to reverse metabolise in vivo into clozapine which has a series of effects on the DREADDs as well as serotonin and dopamine receptors. Alternatives to CNO with more affinity, mre inert character, and faster kinetics include Compound 21 (C21) and deschloroclozapine (DCZ).
A
and an agonist of DREADDs
R
to reverse metabolise
not to enter the brain after administration and to reverse metabolise in vivo
A
the DREADDs as well as
R
inert character
affinity, mre inert character,