Arthroscopic Lavage / Debridement Marrow Stimulation Techniques (Microfracture Surgery and others) Marrow Stimulation augmented with Hydrogel Implant A hydrogel implant to help the body regrow cartilage in the knee is currently being studied in U.S. and European clinical trials. Called GelrinC, the implant is made of a synthetic material called polyethylene glycol (PEG) and denatured human fibrinogen protein. Marrow Stimulation augmented with Peripheral Blood Stem Cells A 2011 study reports histologically confirmed hyaline cartilage regrowth in a 5 patient case-series, 2 with grade IV bipolar or kissing lesions in the knee. The successful protocol involves arthroscopic microdrilling/ microfracture surgery followed by postoperative injections of autologous peripheral blood progenitor cells (PBPC's) and hyaluronic acid (HA). PBPC’s are a blood product containing mesenchymal stem cells and is obtained by mobilizing the stem cells into the peripheral blood. Khay Yong Saw and his team propose that the microdrilling surgery creates a blood clot scaffold on which injected PBPC’s can be recruited and enhance chondrogenesis at the site of the contained lesion. They explain that the significance of this cartilage regeneration protocol is that it is successful in patients with historically difficult-to-treat grade IV bipolar or bone-on-bone osteochondral lesions. Osteochondral Autografts and Allografts Cell Based Repairs Autologous Mesenchymal Stem Cell Transplant See also Autologous Mesenchymal Stem Cell Transplant for Cartilage Growth
Arthroscopic lavage / debridement Marrow stimulation techniques (microfracture surgery and others) Marrow stimulation augmented with hydrogel implant A hydrogel implant to help the body regrow cartilage in the knee is currently being studied in U.S. and European clinical trials. Called GelrinC, the implant is made of a synthetic material called polyethylene glycol (PEG) and denatured human fibrinogen protein. Marrow stimulation augmented with peripheral blood stem cells A 2011 study reports histologically confirmed hyaline cartilage regrowth in a 5 patient case-series, 2 with grade IV bipolar or kissing lesions in the knee. The successful protocol involves arthroscopic microdrilling/ microfracture surgery followed by postoperative injections of autologous peripheral blood progenitor cells (PBPC's) and hyaluronic acid (HA). PBPC’s are a blood product containing mesenchymal stem cells and is obtained by mobilizing the stem cells into the peripheral blood. Khay Yong Saw and his team propose that the microdrilling surgery creates a blood clot scaffold on which injected PBPC’s can be recruited and enhance chondrogenesis at the site of the contained lesion. They explain that the significance of this cartilage regeneration protocol is that it is successful in patients with historically difficult-to-treat grade IV bipolar or bone-on-bone osteochondral lesions. Osteochondral autografts and allografts Cell-based repairs Autologous mesenchymal stem cell transplant See also Stem cell transplantation for articular cartilage repair
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Lavage
lavage
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Debridement
debridement
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Stimulation Techniques (Microfracture Surgery
stimulation techniques (microfracture surgery
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Stimulation augmented with Hydrogel Implant
stimulation augmented with hydrogel implant
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Stimulation augmented with Peripheral Blood Stem Cells
stimulation augmented with peripheral blood stem cells
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Autografts and Allografts
autografts and allografts
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Cell Based Repairs
Cell-based repairs
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Mesenchymal Stem Cell Transplant
mesenchymal stem cell transplant
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Autologous Mesenchymal Stem Cell Transplant for Cartilage Growth
Stem cell transplantation for articular cartilage repair