Various biological sensory systems exhibit a response to the relative change of the stimulus, often reffered to as fold-change detection. Here, we present a mechanism consisting of two interacting proteins, able to detect a fold-change effectively . This mechanism, in contrast to other proposed mechanisms, does not consume chemical energy and is not subject to transcriptional and translational noise. We show by analytical and numerical calculations that the mechanism can have a fast, precise and efficient response for parameters that are relevant to eukaryotic cells.
Various biological sensory systems exhibit a response to the relative change of the stimulus, often referred to as fold-change detection. Here, we present a mechanism consisting of two interacting proteins, that effectively detects a fold-change of the stimulus . This mechanism, in contrast to previously proposed mechanisms, does not consume chemical energy and is not subject to transcriptional and translational noise. We show by analytical and numerical calculations that the mechanism can have a fast, precise and effcient response for parameters that are relevant to eukaryotic cells.
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