We construct a model of a lattice polymer which describes secondary structures of proteins . In this model the energy of a conformation of a polymer is equal to a sum of energies of conformations of segments of the polymer chain of the length five. We show that for this model with cooperative interaction all conformations with minimal energy are combinations of lattice models of alpha-helix and beta-strand. We show that for lattice polymers of the length not longer that 38 monomers we can describe all conformations with minimal energy.
In the standard approach to lattice proteins the models based on nearest neighbor interaction are used. In this kind of models it is difficult to explain the existence of secondary structures --- special preferred conformations of protein chains. In the present paper a new lattice model of proteins is proposed which is based on non-local cooperative interactions . In this model the energy of a conformation of a polymer is equal to the sum of energies of conformations of fragments of the polymer chain of the length five. It is shown that this quinary lattice model is able to describe at qualitative level secondary structures of proteins: for this model all conformations with minimal energy are combinations of lattice models of alpha--helix and beta--strand. Moreover for lattice polymers of the length not longer that 38 monomers we can describe all conformations with minimal energy.
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We construct a model of a lattice polymer which describes secondary structures of proteins
In the standard approach to lattice proteins the models based on nearest neighbor interaction are used. In this kind of models it is difficult to explain the existence of secondary structures --- special preferred conformations of protein chains. In the present paper a new lattice model of proteins is proposed which is based on non-local cooperative interactions
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a
the
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segments
fragments
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We show that
It is shown that this quinary lattice model is able to describe at qualitative level secondary structures of proteins:
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with cooperative interaction
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alpha-helix and beta-strand. We show that
alpha--helix and beta--strand. Moreover