Recently, the RIDL-SIT technology has been field-tested for control of Aedes aegypti . The technique consists of releasing genetically modified mosquitoes carrying a "lethal gene". In 2016 the World Health Organisation (WHO) and the Pan-American Health Organization (PAHO) recommend to their constituent countries to test the new technologies proposed to control Aedes aegypti populations. However, issues concerning effectiveness and ecological impact have not been thoroughly studied so far. In order to study these issues, we develop an ecological model compatible with the information available . It presents an interdependent dynamics of mosquito populations and food in an homogeneous setting. Mosquito populations are described in an stochastic compartmental setup in terms of reaction norms depending on the available food in the environment. The development of the model allow us to indicate some critical biological knowledge that is missing and could (should) be produced. Considering the model results we show how the releases proposed could contribute to the increase of epidemic risk after they have concluded. Hybridisation levelsand release numbers of mosquitoes as a function of intervention duration and target are calculated  .
Recently, the RIDL-SIT technology has been field-tested for control of Aedes aegypti . The technique consists of releasing genetically modified mosquitoes carrying a "lethal gene". In 2016 the World Health Organisation (WHO) and the Pan-American Health Organization (PAHO) recommend to their constituent countries to test the new technologies proposed to control Aedes aegypti populations. However, issues concerning effectiveness and ecological impact have not been thoroughly studied so far. In order to study these issues, we develop an ecological model compatible with the information available as of 2016. It presents an interdependent dynamics of mosquito populations and food in an homogeneous setting. Mosquito populations are described in an stochastic compartmental setup in terms of reaction norms depending on the available food in the environment. The development of the model allows us to indicate some critical biological knowledge that is missing and could (should) be produced. Hybridisation levels, release numbers during and after intervention and population recovery time after the intervention as a function of intervention duration and target are calculated under different hypotheses with regard to the fitness of hybrids and compared with two field studies of actual interventions. The minimal model should serve as a basis for detailed models when the necessary information to construct them is produced. For the time being, the model shows that nature will not clean the non-lethal introgressed genes .
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Aedes aegypti
Aedes aegypti
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Aedes aegypti
Aedes aegypti
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.
as of 2016.
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allow
allows
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Considering the model results we show how the releases proposed could contribute to the increase of epidemic risk after they have concluded. Hybridisation levelsand release numbers of mosquitoes
Hybridisation levels, release numbers during and after intervention and population recovery time after the intervention
A
under different hypotheses with regard to the fitness of hybrids and compared with two field studies of actual interventions. The minimal model should serve as a basis for detailed models when the necessary information to construct them is produced. For the time being, the model shows that nature will not clean the non-lethal introgressed genes