Excitotoxicity ODAP activates AMPA receptors which can induce excitotoxicity, or an overstimulation of glutamate receptors. The release of too much glutamate, either at once or over a prolonged period of time, will lead to increased levels of in the cytoplasm. Since is the signaling molecule for the release of glutamate into the synapse, this can result in potentiation of the glutamate release cycle and the spread of excitotoxic damage to neighboring neurons. Inside the neuron, the extra will leave the cytoplasm and enter either the mitochondria or the endoplasmic reticulum (ER), which can lead to  accumulation of misfolded or unfolded proteins in the ER and ultimately cell death in both cases. In addition to acting as an agonist  there is evidence to show that ODAP is transported into the cell by an antiporter that simultaneously transports glutamate into the synapse.
Excitotoxicity ODAP activates AMPA receptors which can induce excitotoxicity, or overstimulation of glutamate receptors. The release of too much glutamate, either at once or over a prolonged period of time, will lead to increased levels of in the cytoplasm. Since is the signaling ion for the release of glutamate into the synapse, this can result in potentiation of the glutamate release cycle and the spread of excitotoxic damage to neighboring neurons. Inside the neuron, the extra will leave the cytoplasm and enter either the mitochondria or the endoplasmic reticulum (ER), which can lead to the accumulation of misfolded or unfolded proteins in the ER and ultimately cell death in both cases. In addition to acting as an agonist , there is evidence to show that ODAP is transported into the cell by an antiporter that simultaneously transports glutamate into the synapse.
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