Pathophysiology Neural misfiring in the fusiform face area, in the fusiform gyrus (orange), might be a cause of the Cotarddelusion . In the cerebrum, organic lesions in the parietal lobe might cause the Cotarddelusion . The underlying neurophysiology and psychopathology of Cotard  syndrome might be related to problems of delusional misidentification. Neurologically, Cotard's delusion (negation of the Self ) is thought to be related to Capgras delusion (people replaced by impostors); each type of delusion is thought to result from neural misfiring in the fusiform face area of the brain, which recognizes faces, and in the amygdalae, which associate emotions to a recognized face. The neural disconnection creates in the patient a sense that the face they are observing is not the face of the person to whom it belongs; therefore, that face lacks the familiarity (recognition) normally associated with it. This results in derealization or a disconnection from the environment. If the observed face is that of a person known to the patient, they experience that face as the face of an impostor (Capgras delusion). If the patient sees their own face, they might perceive no association between the face and their own sense of self—which results in the patient believing that they do not exist (Cotard delusion ).
Pathophysiology Neural misfiring in the fusiform face area, in the fusiform gyrus (orange), might be a cause of Cotard's syndrome . In the cerebrum, organic lesions in the parietal lobe might cause Cotard's syndrome . The underlying neurophysiology and psychopathology of Cotard 's syndrome might be related to problems of delusional misidentification. Neurologically, Cotard's delusion (negation of the self ) is thought to be related to Capgras delusion (people replaced by impostors); each type of delusion is thought to result from neural misfiring in the fusiform face area of the brain, which recognizes faces, and in the amygdalae, which associate emotions to a recognized face. The neural disconnection creates in the patient a sense that the face they are observing is not the face of the person to whom it belongs; therefore, that face lacks the familiarity (recognition) normally associated with it. This results in derealization or a disconnection from the environment. If the observed face is that of a person known to the patient, they experience that face as the face of an impostor (Capgras delusion). If the patient sees their own face, they might perceive no association between the face and their own sense of self—which results in the patient believing that they do not exist (Cotard 's syndrome ).
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