Different models such as diffusion-collision and nucleation-condensation have been used to unravel how secondary and tertiary structures form during protein folding. However, a simple mechanism based on physical principles that provide an accurate description of kinetics and thermodynamics for such phenomena has not yet been identified. This study introduces the hypothesis that the synchronization of the peptide plane oscillatory movements throughout the backbone may play a key role in folding as a new mechanism. Based on that, we draw a parallel between the folding process and the dynamics for a network of coupled oscillators described by the Kuramoto model. The pattern of synchronized cluster formation, growing and assembling helps to solve the Levinthal's paradox. The amino acid coupling would explain the mean-field character of the force that propels an amino acid sequence into a structure through URLanization  .
Different models such as diffusion-collision and nucleation-condensation have been used to unravel how secondary and tertiary structures form during protein folding. However, a simple mechanism based on physical principles that provide an accurate description of kinetics and thermodynamics for such phenomena has not yet been identified. This study introduces the hypothesis that the synchronization of the peptide plane oscillatory movements throughout the backbone must also play a key role in the folding mechanism. Based on that, we draw a parallel between the folding process and the dynamics for a network of coupled oscillators described by the Kuramoto model. The amino acid coupling may explain the mean-field character of the force that propels an amino acid sequence into a structure through URLanization . Thus, the pattern of synchronized cluster formation and growing helps to solve the Levinthal's paradox .
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pattern of synchronized cluster formation, growing and assembling helps to solve the Levinthal's paradox. The
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. Thus, the pattern of synchronized cluster formation and growing helps to solve the Levinthal's paradox