Proton-pump inhibitors (PPIs) are members of a class of medications whose main action is a profound and prolonged reduction of stomach acid production. Within the class of medications, there is no clear evidence that one agent works better than another . They are the most potent inhibitors of acid secretion available. This group of medications followed and largely superseded another group of medications with similar effects , but a different mode of action , the H2-receptor antagonists . Examples Medically used proton pump inhibitors: Omeprazole (Over-the-counter drug (OTC) and Rx-only in the US)"Omeprazole and Esomeprazole". Clinical and Research Information on Drug-induced Liver Injury. National Institutes of Health (NIH). Retrieved May 8, 2018. Lansoprazole (OTC and Rx-only in the US)"Lansoprazole, Dexlansoprazole". Clinical and Research Information on Drug-induced Liver Injury. National Institutes of Health (NIH). Retrieved May 8, 2018. Dexlansoprazole Esomeprazole (OTC and Rx-only in the US and Australia) Pantoprazole"Pantoprazole". Clinical and Research Information on Drug-induced Liver Injury. National Institutes of Health (NIH). Retrieved May 8, 2018. Rabeprazole"Rabeprazole". Clinical and Research Information on Drug-induced Liver Injury. National Institutes of Health (NIH). Retrieved May 8, 2018. Ilaprazole (not FDA-approved ) 
Proton-pump inhibitors (PPIs) are a class of medications that cause a profound and prolonged reduction of stomach acid production. They do so by irreversibly inhibiting the stomach's H+/K+ ATPase proton pump . They are the most potent inhibitors of acid secretion available. Proton-pump inhibitors have largely superseded the H2-receptor antagonists, a group of medications with similar effects but a different mode of action . Examples Medically used proton pump inhibitors: Omeprazole (Over-the-counter drug (OTC) and Rx-only in the US)"Omeprazole and Esomeprazole". Clinical and Research Information on Drug-induced Liver Injury. National Institutes of Health (NIH). Retrieved May 8, 2018. Lansoprazole (OTC and Rx-only in the US)"Lansoprazole, Dexlansoprazole". Clinical and Research Information on Drug-induced Liver Injury. National Institutes of Health (NIH). Retrieved May 8, 2018. Dexlansoprazole Esomeprazole (OTC and Rx-only in the US and Australia) Pantoprazole"Pantoprazole". Clinical and Research Information on Drug-induced Liver Injury. National Institutes of Health (NIH). Retrieved May 8, 2018. Rabeprazole"Rabeprazole". Clinical and Research Information on Drug-induced Liver Injury. National Institutes of Health (NIH). Retrieved May 8, 2018. Ilaprazole (not FDA-approved ) There is no clear evidence that one proton pump inhibitor works better than another.
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Within the class of medications, there is no clear evidence that one agent works better than another
They do so by irreversibly inhibiting the stomach's H+/K+ ATPase proton pump
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This group of medications followed and largely superseded another
Proton-pump inhibitors have largely superseded the H2-receptor antagonists, a
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, the H2-receptor antagonists
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There is no clear evidence that one proton pump inhibitor works better than another.