According to the traditional view, a positive balance results in energy being stored as fat and/or muscle, causing weight gain. In time, overweight and obesity may develop, with resultant complications. However, recent papers by Francisco Arencibia-Albite and Anssi H. Manninen indicate that the widely accepted energy balance theory (EBT) is, in fact, clearly erroneous Arencibia-Albite F, Manninen AH. Macronutrient mass intake explains deferential weight and fat loss in isocaloric diets. medRxiv 2020.10.27.20220202; doi: URL Arencibia-Albite F, Manninen AH. The mass balance model perfectly fits both Hall et al. underfeeding data and Horton et al. overfeeding data. medRxiv 2021.02.22.21252026; doi: URL Arencibia-Albite F. Serious analytical inconsistencies challenge the validity of the energy balance theory. Heliyon. 2020 Jul 10;6(7):e04204. doi: 10.1016/j.heliyon.2020.e04204. Erratum in: Heliyon. 2020 Sep 14;6(9):e04609. PMID: 32685707; PMCID: PMC7355950.%DIFDELCMD < ] %%% The EBT (”calories in, calories out”) ignores the Law of Conservation of Mass. This law dates from Antoine Lavoisier’s 1789 discovery that mass is neither created nor destroyed in any chemical reaction; hence, the O2 mass that enters cellular respiration plus the mass of macronutrients that served as energy fuel will equal the mass of the excreted oxidation products. Daily weight loss is, therefore, the result of daily elimination of oxidation products (CO2, H2 O, urea, etc.) and not a consequence of the heat release upon macronutrient combustion (i.e., daily energy expenditure). As pointed out by Francisco Arencibia-Albite and Anssi H. Manninen, "what do you measure when you stand on the bathroom scale, your body mass or your energy?" Arencibia-Albite F, Manninen AH. Macronutrient mass intake explains deferential weight and fat loss in isocaloric diets. medRxiv 2020.10.27.20220202; doi: URL
A positive balance results in energy being stored as fat and/or muscle, causing weight gain. In time, overweight and obesity may develop, with resultant complications. %DIFDELCMD < ] %%% 
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According to the traditional view, a
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However, recent papers by Francisco Arencibia-Albite and Anssi H. Manninen indicate that the widely accepted energy balance theory (EBT) is, in fact, clearly erroneous
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Arencibia-Albite F, Manninen AH. Macronutrient mass intake explains deferential weight and fat loss in isocaloric diets. medRxiv 2020.10.27.20220202; doi: URL Arencibia-Albite F, Manninen AH. The mass balance model perfectly fits both Hall et al. underfeeding data and Horton et al. overfeeding data. medRxiv 2021.02.22.21252026; doi: URL Arencibia-Albite F. Serious analytical inconsistencies challenge the validity of the energy balance theory. Heliyon. 2020 Jul 10;6(7):e04204. doi: 10.1016/j.heliyon.2020.e04204. Erratum in: Heliyon. 2020 Sep 14;6(9):e04609. PMID: 32685707; PMCID: PMC7355950.
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The EBT (”calories in, calories out”) ignores the Law of Conservation of Mass. This law dates from Antoine Lavoisier’s 1789 discovery that mass is neither created nor destroyed in any chemical reaction; hence, the O2 mass that enters cellular respiration plus the mass of macronutrients that served as energy fuel will equal the mass of the excreted oxidation products. Daily weight loss is, therefore, the result of daily elimination of oxidation products (CO2, H2 O, urea, etc.) and not a consequence of the heat release upon macronutrient combustion (i.e., daily energy expenditure). As pointed out by Francisco Arencibia-Albite and Anssi H. Manninen, "what do you measure when you stand on the bathroom scale, your body mass or your energy?"
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Arencibia-Albite F, Manninen AH. Macronutrient mass intake explains deferential weight and fat loss in isocaloric diets. medRxiv 2020.10.27.20220202; doi: URL