MRK-016 is a selective α5 subunit-containing GABAA negative allosteric modulator  ] ] that has nootropic properties. It has been found to produce rapid, ketamine-like antidepressant effects in animal models of depression.
MRK-016 is a selective α5 subunit-containing GABAA negative allosteric modulator ,Atack JR, Maubach KA, Wafford KA, et al. In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo 1,5-d]- 1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist. J Pharmacol Exp Ther. 2009;331(2):470-484. that has nootropic properties. It has been found to produce rapid, ketamine-like antidepressant effects in animal models of depression.
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,Atack JR, Maubach KA, Wafford KA, et al. In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo
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1,5-d
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1,2,4
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triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist. J Pharmacol Exp Ther. 2009;331(2):470-484.