It was shown in C. elegans that life-long treatments with low level of the prooxidant paraquat increased ROS , which then acted as the signal to slow down aging by activating the intrinsic apoptosis pathway. And deficiencies of the electron transport chain subunits increased longevity through similar mechanisms. We surprisingly found that ROS were down- and up-regulated respectively upon chronic and transient paraquat treatments, although the same ROS measuring approaches were applied. Adaptive responses were shown to be responsible for the reduction under chronic stress. Post young adult stage started treatments shortened lifespan at all concentrations tested, and mild extension was only observed by treating with proper concentration of paraquat from egg hatching. However, the extension in the latter case can be fully explained by growth retardation. Thus, paraquat actually accelerated aging rather than slowed down it. The interactions between oxidative stress, ROS, and aging should be more elegant than thought .
The view that ROS slow down aging is getting popular. We here proposed an idea that aging is slowed down by secondary responses rather than ROS .
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It was shown in C. elegans that life-long treatments with low level of the prooxidant paraquat increased ROS , which then acted as the signal to
The view that ROS
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by activating the intrinsic apoptosis pathway. And deficiencies of the electron transport chain subunits increased longevity through similar mechanisms. We surprisingly found that ROS were down- and up-regulated respectively upon chronic and transient paraquat treatments, although the same ROS measuring approaches were applied. Adaptive responses were shown to be responsible for the reduction under chronic stress. Post young adult stage started treatments shortened lifespan at all concentrations tested, and mild extension was only observed by treating with proper concentration of paraquat from egg hatching. However, the extension in the latter case can be fully explained by growth retardation. Thus, paraquat actually accelerated aging rather than slowed down it. The interactions between oxidative stress, ROS, and aging should be more elegant than thought
is getting popular. We here proposed an idea that aging is slowed down by secondary responses rather than ROS