Dynamical robustness and modularity in cellular processes are considered as special characters in biological regulatory network.  Here we construct a simplified cell-cycle model in budding yeast to investigate the underlying mechanism that ensures the robustness in the multi-step process . First, we establish a three-variable model and select a parameter set that can qualitatively describe the yeast cell-cycle process. Then, through nonlinear dynamical analysis we demonstrate that the yeast cell-cycle process is an excited system driven by a sequence of saddle-node bifurcations with ghost effects , and the yeast cell-cycle trajectory is globally attractive with modularity in both state and parameter space, while the convergent manifold provides a suitable control state for cell-cycle checkpoints. These results highlight the dynamical regulatory mechanism for complex biological processes to execute successive events and multi-task .
Yeast cells produce daughter cells through a DNA replication and mitosis cycle associated with checkpoints and governed by the cell cycle regulatory network. To ensure genome stability and genetic information inheritance, this regulatory network must be dynamically robust against various fluctuations. Here we construct a simplified cell cycle model for a budding yeast to investigate the underlying mechanism that ensures robustness in this process containing sequential tasks (DNA replication and mitosis). We first establish a three-variable model and select a parameter set that qualitatively describes the yeast cell cycle process. Then, through nonlinear dynamic analysis, we demonstrate that the yeast cell cycle process is an excitable system driven by a sequence of saddle-node bifurcations with ghost effects . We further show that the yeast cell cycle trajectory is globally attractive with modularity in both state and parameter space, while the convergent manifold provides a suitable control state for cell cycle checkpoints. These results not only highlight a regulatory mechanism for executing successive cell cycle processes, but also provide a possible strategy for the synthetic network design of sequential-task processes .
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Dynamical robustness and modularity in cellular processes are considered as special characters in biological
Yeast cells produce daughter cells through a DNA replication and mitosis cycle associated with checkpoints and governed by the cell cycle
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To ensure genome stability and genetic information inheritance, this regulatory network must be dynamically robust against various fluctuations.
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cell-cycle model in
cell cycle model for a
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the robustness in the multi-step process . First, we
robustness in this process containing sequential tasks (DNA replication and mitosis). We first
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can qualitatively describe the yeast cell-cycle
qualitatively describes the yeast cell cycle
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dynamical analysis
dynamic analysis,
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cell-cycle
cell cycle
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excited
excitable
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, and the yeast cell-cycle
. We further show that the yeast cell cycle
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cell-cycle
cell cycle
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highlight the dynamical
not only highlight a
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complex biological processes to execute successive events and multi-task
executing successive cell cycle processes, but also provide a possible strategy for the synthetic network design of sequential-task processes