Metascreen Metascreen is an advanced non-invasive metabolic screening test distributed by Cordlife Group Limited ( “Cordlife” ). It can detect as many as 110 inborn errors of metabolism ( “IEMs” , or metabolic disorders) from a urine specimen. Cordlife owns the brand name and trademark, “Metascreen” . Unlike the conventional dried blood spot test for newborn screening that involves a painful heel prick, Metascreen uses urine specimen, collected without harm or discomfort to the newborn, to detect as many as 110 metabolic disorders. The urine specimen is collected on a filter paper, which is then air-dried and sent to the laboratory for analysis using a gas chromatography-mass spectrometry instrument ( “ GC-MS ” ). GC-MS is a FDA approved method for urinary analyte detection, a gold standard for lipids, drug metabolites and environmental analysis. Many of the IEMs that are classified as “organic acidemia” , in which organic acids accumulate in the urine of newborns with these disorders, are easily and accurately picked up by GC-MS.. The GC-MS platform is recommended by the American College of Medical Genetics for the detection of organic and amino acidemias through the urine. Furthermore, the platform has also been shown to be reliable in detecting other types of IEMs, such as sugar metabolism disorders and fatty acid oxidation disorders. Indeed, GC-MS analysis is increasingly becoming a common way to diagnose IEMs for earlier intervention and treatment, resulting in a better outcome and quality of life. Category:Neonatology * Category:Epidemiology Category:Rare d
Metascreen is an advanced non-invasive metabolic screening test distributed by Cordlife Group Limited ( "Cordlife" ). It can detect as many as 110 inborn errors of metabolism ( "IEMs" , or metabolic disorders) from a urine specimen. Cordlife owns the brand name and trademark, "Metascreen" . Unlike the conventional dried blood spot test for newborn screening that involves a painful heel prick, Metascreen uses urine specimen, collected without harm or discomfort to the newborn, to detect as many as 110 metabolic disorders. The urine specimen is collected on a filter paper, which is then air-dried and sent to the laboratory for analysis using a gas chromatography-mass spectrometry instrument ( " GC-MS " ). GC-MS is a FDA approved method for urinary analyte detection, a gold standard for lipids, drug metabolites and environmental analysis. Many of the IEMs that are classified as "organic acidemia" , in which organic acids accumulate in the urine of newborns with these disorders, are easily and accurately picked up by GC-MS.. The GC-MS platform is recommended by the American College of Medical Genetics for the detection of organic and amino acidemias through the urine. Furthermore, the platform has also been shown to be reliable in detecting other types of IEMs, such as sugar metabolism disorders and fatty acid oxidation disorders. Indeed, GC-MS analysis is increasingly becoming a common way to diagnose IEMs for earlier intervention and treatment, resulting in a better outcome and quality of life. Category:Neonatology Category:Inborn errors of metabolism Category:Epidemiology Category:Rare d
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Metascreen
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“Cordlife”
"Cordlife"
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“IEMs”
"IEMs"
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“Metascreen”
"Metascreen"
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“organic acidemia”
"organic acidemia"
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Category:Inborn errors of metabolism