Synthesis of proteins is one of the most fundamental biological processes, which consumes a significant amount of cellular resources. Despite many efforts to produce detailed mechanistic mathematical models of translation,  no basic and simple  kinetic model of mRNA lifecycle (transcription, translation and degradation) exists. We build such a model by lumping multiple states of translated mRNA into few dynamical variables and introducing a pool of translating ribosomes. The  basic and simple model can be extended, if necessary, to take into account various phenomena such as the interaction between translating ribosomes  or regulation of translation by microRNA. The model can be used as a building block (translation module) for more complex models of cellular processes  .
Protein synthesis is one of the most fundamental biological processes, which consumes a significant amount of cellular resources. Despite existence of multiple mathematical models of translation, varying in the level of mechanistical details, surprisingly, there is no basic and simple chemical kinetic model of this process, derived directly from the detailed kinetic model. One of the reasons for this is that the translation process is characterized by indefinite number of states, thanks to existence of polysomes. We bypass this difficulty by applying a trick consisting in lumping multiple states of translated mRNA into few dynamical variables and by introducing a variable describing the pool of translating ribosomes. The simplest model can be solved analytically under some assumptions. The basic and simple model can be extended, if necessary, to take into account various phenomena such as the interaction between translating ribosomes , limited amount of ribosomal units or regulation of translation by microRNA. The model can be used as a building block (translation module) for more complex models of cellular processes . We demonstrate the utility of the model in two examples. First, we determine the critical parameters of the single protein synthesis for the case when the ribosomal units are abundant. Second, we demonstrate intrinsic bi-stability in the dynamics of the ribosomal protein turnover and predict that a minimal number of ribosomes should pre-exists in a living cell to sustain its protein synthesis machinery, even in the absence of proliferation .
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Synthesis of proteins
Protein synthesis
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many efforts to produce detailed mechanistic
existence of multiple
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varying in the level of mechanistical details, surprisingly, there is
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chemical
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mRNA lifecycle (transcription, translation and degradation) exists. We build such a model by
this process, derived directly from the detailed kinetic model. One of the reasons for this is that the translation process is characterized by indefinite number of states, thanks to existence of polysomes. We bypass this difficulty by applying a trick consisting in
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introducing a
by introducing a variable describing the
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simplest model can be solved analytically under some assumptions. The
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, limited amount of ribosomal units
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. We demonstrate the utility of the model in two examples. First, we determine the critical parameters of the single protein synthesis for the case when the ribosomal units are abundant. Second, we demonstrate intrinsic bi-stability in the dynamics of the ribosomal protein turnover and predict that a minimal number of ribosomes should pre-exists in a living cell to sustain its protein synthesis machinery, even in the absence of proliferation