Heat-bath cooling is a component of practicable algorithmic cooling of spins, an approach which might be useful for in vivo 13C spectroscopy, in particular for prolonged metabolic processes where substrates that are hyperpolarized ex-vivo are not effective. We applied heat-bath cooling to 1,2-13C2-amino acids, using the \alpha\ protons to shift entropy from selected carbons to the environment. For glutamate and glycine, the polarizations of both labeled carbons were enhanced , and in other experiments the total entropy of each spin system was shown to decrease . The effect of adding Magnevist, a gadolinium contrast agent, on heat-bath cooling of glutamate was investigated.
Heat-bath cooling is a component of practicable algorithmic cooling of spins, an approach which might be useful for in vivo 13C spectroscopy, in particular for prolonged metabolic processes where substrates that are hyperpolarized ex-vivo are not effective. We applied heat-bath cooling to 1,2-13C2-amino acids, using the alpha protons to shift entropy from selected carbons to the environment. For glutamate and glycine, both carbons were cooled by about 2.5-fold , and in other experiments the polarization of C1 nearly doubled while all other spins had equilibrium polarization, indicating reduction in total entropy . The effect of adding Magnevist, a gadolinium contrast agent, on heat-bath cooling of glutamate was investigated.
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\alpha\
alpha
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the polarizations of both labeled carbons were enhanced
both carbons were cooled by about 2.5-fold
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total entropy of each spin system was shown to decrease
polarization of C1 nearly doubled while all other spins had equilibrium polarization, indicating reduction in total entropy