We study translocation dynamics of a driven compressible semi-flexible chain consisting of alternate blocks of stiff (S) and flexible (F) segments of size m and n respectively for different chain length N  . The free parameters in the model are the bending rigidity \kappa_b which controls the three body interaction term, the elastic constant k_F in the FENE (bond) potential between successive monomers, as well as the block lengths m and n and the repeat unit p (N=m_pn_p)  . We demonstrate that the due to change in the entropic barrier and the inhomogeneous friction on the chain  a variety of scenario are possible amply manifested in the incremental mean first passage time (IMFPT) or in the waiting time distribution of the translocating chain. These informations can be deconvoluted to extract information about the mechanical properties of the chain at various length scales and thus can be used to nanopore based methods to probe biomolecules , such as DNA, RNA and proteins.
We study translocation dynamics of a driven compressible semi-flexible chain consisting of alternate blocks of stiff (S) and flexible (F) segments of size m and n respectively for different chain length N in two dimension (2D) . The free parameters in the model are the bending rigidity \kappa_b which controls the three body interaction term, the elastic constant k_F in the FENE (bond) potential between successive monomers, as well as the segmental lengths m and n and the repeat unit p (N=m_pn_p) and the solvent viscosity \gamma . We demonstrate that due to the change in entropic barrier and the inhomogeneous viscous drag on the chain backbone a variety of scenarios are possible amply manifested in the waiting time distribution of the translocating chain. These information can be deconvoluted to extract the mechanical properties of the chain at various length scales and thus can be used to nanopore based methods to probe bio-molecules , such as DNA, RNA and proteins.
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in two dimension (2D)
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block
segmental
A
and the solvent viscosity \gamma
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the due to change in the
due to the change in
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friction
viscous drag
A
backbone
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scenario
scenarios
D
incremental mean first passage time (IMFPT) or in the
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informations
information
D
information about
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biomolecules
bio-molecules