The extension of DNA during confinement in a nanochannel has attracted substantial attention for next-generation genomics and as a fundamental problem in polymer physics. But recent experiments measuring DNA extension in nanochannels are at odds with even the most basic predictions of current scaling arguments for the conformations of confined semiflexible polymers such as DNA. We posit that this discrepancy arises because the experimental systems do not satisfy the strong inequalities underlying existing scaling approximations. We develop a new theory , based on the properties of a  weakly self-avoiding, one-dimensional "telegraph" process , that collapses both experimental data and computer-simulation results onto a single master curve throughout the experimentally relevant region of parameter space  .
Experiments measuring DNA extension in nanochannels are at odds with even the most basic predictions of current scaling arguments for the conformations of confined semiflexible polymers such as DNA. We show that a theory based on a weakly self-avoiding, one-dimensional "telegraph" process collapses experimental data and simulation results onto a single master curve throughout the experimentally relevant region of parameter space and explains the mechanisms at play .
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The extension of DNA during confinement in a nanochannel has attracted substantial attention for next-generation genomics and as a fundamental problem in polymer physics. But recent experiments
Experiments
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posit that this discrepancy arises because the experimental systems do not satisfy the strong inequalities underlying existing scaling approximations. We develop a new theory , based on the properties of
show that
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theory based on a
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, that collapses both
collapses
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computer-simulation
simulation
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and explains the mechanisms at play