The Ferguson reflex (also called the fetal ejection reflex) is the neuroendocrine reflex comprising the self-sustaining cycle of uterine contractions initiated by pressure at the cervix more precise- internal end of cervix  or vaginal walls. It is an example of positive feedback in biology. The Ferguson reflex occurs in mammals. Sensory information regarding mechanical stretch of the cervix is carried in a sensory neuron, which synapses in the dorsal horn before ascending to the brain in the anterolateral columns (ipsilateral and contralateral routes). Via the median forebrain bundle, the efferent reaches the PVN and SON of the hypothalamus. The posterior pituitary releases oxytocin due to increased firing in the hypothalamo-hypophyseal tract. Oxytocin acts on the myometrium, on receptors which have been upregulated by a functional increase of the estrogen-progesterone ratio. This functional ratio change is mediated by a decrease in myometrial sensitivity to progesterone, due to a decrease in progesterone receptor A, and a concurrent increase in myometrial sensitivity to estrogen, due to an increase in estrogen receptor α. This causes myometrial contraction and further positive feedback on the reflex.Martin H. Johnson, Essential Reproduction 6th edition (2007). Blackwell Publishing Ferguson , J.K.W. A study of the motility of the intact uterus at term. Surg Gynecol Obstet 1941. 73: 359-66 Studies among ewes demonstrated that it is blocked by epidural anesthesia.Flint AP, Forsling ML, Mitchell MD. Blockade of the Ferguson reflex by lumbar epidural anaesthesia in the parturient sheep: effects on oxytocin secretion and uterine venous prostaglandin F levels. Horm Metab Res. 1978 Nov;10(6):545-7 In their studies among mice, Niles Newton and colleagues demonstrated the importance of cortical influences.Newton N, Foshee D, Newton M. Experimental inhibition of labor through environmental disturbance. Obstetrics and Gynecology 1967; 371-377 They enlarged the topic by introducing the term fetus ejection reflex. The concept of cortical influences provided reasons to raise questions about the process of parturition among humans, characterized by a high encephalization quotient.  Odent had observed that , in situations that are exceptionally rare, women can occasionally experience such a reflex, characterized by a birth after a short series of irresistible and powerful contractions without any room for voluntary movements  . For such a hormonal cascade to occur , requires sufficient psychological safety, as occurs in normal or undisturbed birth. The higher the intervention rate, such as induction or caesarian section, the lower the likelihood of the Ferguson Reflex occurring. In contrast, the lower the incidence of intervention, such as is found in those countries with high rate of home births, and birth centres worldwide, the higher the likelihood of the Ferguson Reflex occurring. This may explain the lack of research, considering the public health benefits of such education to both hospitals and the general public.
The Ferguson reflex (also called the fetal ejection reflex) is the neuroendocrine reflex comprising the self-sustaining cycle of uterine contractions initiated by pressure at the cervix, more precisely, the internal end of cervix , or vaginal walls. It is an example of positive feedback in biology. The Ferguson reflex occurs in mammals. Sensory information regarding mechanical stretch of the cervix is carried in a sensory neuron, which synapses in the dorsal horn before ascending to the brain in the anterolateral columns (ipsilateral and contralateral routes). Via the medial forebrain bundle, the efferent reaches the PVN and SON of the hypothalamus. The posterior pituitary releases oxytocin due to increased firing in the hypothalamo-hypophyseal tract. Oxytocin acts on the myometrium, on receptors which have been upregulated by a functional increase of the estrogen-progesterone ratio. This functional ratio change is mediated by a decrease in myometrial sensitivity to progesterone, due to a decrease in progesterone receptor A, and a concurrent increase in myometrial sensitivity to estrogen, due to an increase in estrogen receptor α. This causes myometrial contraction and further positive feedback on the reflex.Martin H. Johnson, Essential Reproduction 6th edition (2007). Blackwell PublishingFerguson , J.K.W. A study of the motility of the intact uterus at term. Surg Gynecol Obstet 1941. 73: 359-66 Studies among ewes demonstrated that it is blocked by epidural anesthesia.Flint AP, Forsling ML, Mitchell MD. Blockade of the Ferguson reflex by lumbar epidural anaesthesia in the parturient sheep: effects on oxytocin secretion and uterine venous prostaglandin F levels. Horm Metab Res. 1978 Nov;10(6):545-7 In their studies among mice, Niles Newton and colleagues demonstrated the importance of cortical influences.Newton N, Foshee D, Newton M. Experimental inhibition of labor through environmental disturbance. Obstetrics and Gynecology 1967; 371-377 They enlarged the topic by introducing the term fetus ejection reflex. The concept of cortical influences provided reasons to raise questions about the process of parturition among humans, characterized by a high encephalization quotient. Michel Odent had observed that women can experience such a reflex, characterized by a birth after a short series of irresistible and powerful contractions without any room for voluntary movements , resulting in a painless birth . For such a hormonal cascade to occur requires sufficient psychological safety, as occurs in normal or undisturbed birth. The higher the intervention rate, such as induction or caesarian section, the lower the likelihood of the Ferguson Reflex occurring. In contrast, the lower the incidence of intervention, such as is found in those countries with high rate of home births, and birth centers worldwide, the higher the likelihood of the Ferguson Reflex occurring. This may explain the lack of research, considering the public health benefits of such education to both hospitals and the general public.
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cervix
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more precise-
cervix, more precisely, the
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medial
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Ferguson
PublishingFerguson
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Michel
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, in situations that are exceptionally rare, women can occasionally
women can
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, resulting in a painless birth
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centres
centers