A new quantized ion channel model, called five-anchor model, is proposed based on a simple hypothesis of the first principle of the protein beam in the ion channel : the polarity of the protein beam can be changed by electron transition. With this model , many unique properties and behaviors of ion channels can be explained, including the real physical working mechanism of optogenetics, the refractory period in activation of action potential, the stochastic gating pattern of single ion channel and the nerve conductance block . Meanwhile, this model is consistent with our previous C-P theory. In this study, the probability calculus equation is amended and expanded to a more general scenario, thus called a general probability for differentiation with the probability calculus in C-P theory.
A quantized physical framework, called the five-anchor model, is developed for a general understanding of the working mechanism of ion channels. According to the hypotheses of this model, the following two basic physical principles are assigned to each anchor : the polarity change induced by an electron transition and the mutual repulsion and attraction induced by an electrostatic force. Consequently , many unique phenomena, such as fast and slow inactivation, the stochastic gating pattern and constant conductance of a single ion channel , the difference between electrical and optical stimulation (optogenetics), nerve conduction block and the generation of an action potential, become intrinsic features of this physical model. Moreover, this model also provides a foundation for the probability equation used to calculate the results of electrical stimulation in our previous C-P theory.
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new quantized ion channel model, called
quantized physical framework, called the
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proposed based on a simple hypothesis of the first principle of the protein beam in the ion channel
developed for a general understanding of the working mechanism of ion channels. According to the hypotheses of this model, the following two basic physical principles are assigned to each anchor
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of the protein beam can be changed by electron transition. With this model
change induced by an electron transition and the mutual repulsion and attraction induced by an electrostatic force. Consequently
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properties and behaviors of ion channels can be explained, including the real physical working mechanism of optogenetics, the refractory period in activation of action potential, the
phenomena, such as fast and slow inactivation, the
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of
and constant conductance of a
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and the nerve conductance block . Meanwhile, this model is consistent with our previous C-P theory. In this study, the probability calculus equation is amended and expanded to a more general scenario, thus called a general probability for differentiation with the probability calculus in
, the difference between electrical and optical stimulation (optogenetics), nerve conduction block and the generation of an action potential, become intrinsic features of this physical model. Moreover, this model also provides a foundation for the probability equation used to calculate the results of electrical stimulation in our previous