A continuum model for epithelial tissue mechanics is formulated from cell level mechanical ingredients and morphogenetic cell dynamics, including cell  shape changes and cell rearrangements. The model is capable of dealing with finite deformation, and uses stress and deformation tensors that can be compared with experimental data. Using the model, we uncover the dynamical behaviour that underlies passive relaxationand active contraction-elongation of a tissue . The present work provides an integrated scheme for understanding the mechanisms by which morphogenetic processes of each individual cell collectively lead to the development of a large tissue with its correct shape and size .
A continuum model of epithelial tissue mechanics was formulated using cellular-level mechanical ingredients and cell morphogenetic processes, including cellular shape changes and cellular rearrangements. This model can include finite deformation, and incorporates stress and deformation tensors , which can be compared with experimental data. Using this model, we elucidated dynamical behavior underlying passive relaxation, active contraction-elongation , and tissue shear flow. This study provides an integrated scheme for the understanding of the mechanisms that are involved in orchestrating the morphogenetic processes in individual cells, in order to achieve epithelial tissue morphogenesis .
R
for
of
R
is formulated from cell level
was formulated using cellular-level
D
morphogenetic cell dynamics, including
A
morphogenetic processes, including cellular
R
cell rearrangements. The model is capable of dealing with
cellular rearrangements. This model can include
R
uses
incorporates
R
that
, which
R
the
this
R
uncover the dynamical behaviour that underlies passive relaxationand
elucidated dynamical behavior underlying passive relaxation,
R
of a tissue . The present work
, and tissue shear flow. This study
R
understanding the mechanisms by which morphogenetic processes of each individual cell collectively lead to the development of a large tissue with its correct shape and size
the understanding of the mechanisms that are involved in orchestrating the morphogenetic processes in individual cells, in order to achieve epithelial tissue morphogenesis