Subcellular Location The nucleus is the most likely home of C16orf90's produced protein and is not a transmembrane protein. These results were verified by comparing the results of the homologous mouse and dolphin C16orf90 proteins. Structure Secondary Structure mRNA The mRNA secondary structure found by RNAfold appeared to show medium to high affinity for the structure produced with stem-loop and hairpin turns. Only two areas indicated a low probability for the secondary structure produced. Tertiary Structure C16orf90's tertiary structure includes linear alpha-helices separated by a disordered or coiled-coil region. Protein Level Regulation A nuclear localization signal (NLS) at the C-terminus of the protein from 173-197 supports the subcellular localization prediction. Post Translational Modifications Phosphorylation occurs at many amino acids on C16orf90. The red markers on the protein schematic indicate likely phosphorylation sites. NetPhos, a phosphorylation site predictor, returned many sites including amino acids 16, 34, 56, 63, 67, 86, 130, 144, 147, 148, 150, 151, 152, 153, 165, 167, 174, 177, 189, and 191. Homology Evolution C16orf90 orthologs have a relatively high mutation rate as seen in the graph to the right comparing C16orf90 with fibrinopeptides, hemoglobin, and cytochrome C. The orthologs are sorted by increasing date of divergence and sequence similarity. C16orf90 is limited to mammals but is found in monotremes and marsupials indicating the gene entered the genome around 180 million years ago. GenusSpeciesCommon nameTaxonomic GroupDate of Divergence (MYA)Accession NumberSequence length (AA) Sequency identity to humanSequence Similarity to humanHomosapiensHumansPrimates0.00XP_024306160.1197100.00\%100.00\%GorillagorillaGorillaPrimates8.6XP_00405713918582.00\%82.50\%MusmusculusMouseRodentia89NP_082760.217163.50\%66.50\%BisonbisonBisonEven-Toed Ungulate94XP_01083868218665.50\%69.00\%ZalophuscalifornianusSea LionCarnivora94XP _027973424.118565.2069.10\%Canis LupisfamiliarisDogCarnivora94XP _003434913.2 21464.50\%69.60\%EquuscaballusHorseOdd-Toed Ungulate94XP _001502184.118363.70\%67.60\%SorexaraneusCommon shrewSoricomorphas94XP_004600963.132063.87\%70.00\%AcinonyxjubatusCheetahCarnivora94XP_02689921122561.90\%67.30\%PteropusvampyrusLarge Flying FoxChiroptera94XP _023376984.122461.80\%64.50\%LagenorhynchusobliquidensPacific White-Sided DolphinArtiodactyla94XP _02697416019254.30\%58.00\% DasypusnovemcinctusNine-Banded ArmadilloCingulata102XP _004474400.118561.30\%67.20\%OrycteropusaferAardvarkTubulidentata102.00XP_007937762.118559.80\%65.70\%MonodelphisdomesticaGray Short-Tailed OpossumMarsupial160 .00XP_001363889.118753.80\%60.50\%PhascolarctoscinereusKoalaMarsupial160.00XP_020851162.118753.10\%60.20\%OrnithorhynchusanatinusPlatypusMonotreme180.00XP_016082126.221633.90\%40.40\% Clinical Significance In research, the sequence has been identified as containing a possible pathogenic recessive variant (K53N) for various intellectual disabilities among 31 others.. The protein is suspected to be an adaptor/cofactor that binds to other molecules. In this case a non-homologous substitution could change binding to other molecules and potentially cause intellectual disability, inguinal hernia, frontal upsweep of hair, macrotia, high palate, hypertonia, hyperreflexia, abnormality of the cerebrum, or vitamin D deficiency
Subcellular location The nucleus is the most likely home of C16orf90's produced protein and is not a transmembrane protein. These results were verified by comparing the results of the homologous mouse and dolphin C16orf90 proteins. Structure Secondary structure mRNA The mRNA secondary structure found by RNAfold appeared to show medium to high affinity for the structure produced with stem-loop and hairpin turns. Only two areas indicated a low probability for the secondary structure produced. Tertiary structure C16orf90's tertiary structure includes linear alpha-helices separated by a disordered or coiled-coil region. Protein level regulation A nuclear localization signal (NLS) at the C-terminus of the protein from 173-197 supports the subcellular localization prediction. Post translational modifications Phosphorylation occurs at many amino acids on C16orf90. The red markers on the protein schematic indicate likely phosphorylation sites. NetPhos, a phosphorylation site predictor, returned many sites including amino acids 16, 34, 56, 63, 67, 86, 130, 144, 147, 148, 150, 151, 152, 153, 165, 167, 174, 177, 189, and 191. Homology and evolution C16orf90 orthologs have a relatively high mutation rate as seen in the graph to the right comparing C16orf90 with fibrinopeptides, hemoglobin, and cytochrome C. The orthologs are sorted by increasing date of divergence and sequence similarity. C16orf90 is limited to mammals but is found in monotremes and marsupials indicating the gene entered the genome around 180 million years ago. GenusSpeciesCommon nameTaxonomic groupDate of divergence (MYA)Accession numberSequence length (AA) Sequence identity to humanSequence similarity to humanHomosapiensHumansPrimates0.00XP_024306160.1197100.00\%100.00\%GorillagorillaGorillaPrimates8.6XP_00405713918582.00\%82.50\%MusmusculusMouseRodentia89NP_082760.217163.50\%66.50\%BisonbisonBisonEven-Toed Ungulate94XP_01083868218665.50\%69.00\%ZalophuscalifornianusSea lionCarnivora94XP _027973424.118565.2069.10\%Canis lupusfamiliarisDogCarnivora94XP _003434913.2 21464.50\%69.60\%EquuscaballusHorseOdd-Toed ungulate94XP _001502184.118363.70\%67.60\%SorexaraneusCommon shrewSoricomorphas94XP_004600963.132063.87\%70.00\%AcinonyxjubatusCheetahCarnivora94XP_02689921122561.90\%67.30\%PteropusvampyrusLarge flying foxChiroptera94XP _023376984.122461.80\%64.50\%LagenorhynchusobliquidensPacific white-sided dolphinArtiodactyla94XP _02697416019254.30\%58.00\% DasypusnovemcinctusNine-banded armadilloCingulata102XP _004474400.118561.30\%67.20\%OrycteropusaferAardvarkTubulidentata102.00XP_007937762.118559.80\%65.70\%MonodelphisdomesticaGray short-tailed opossumMarsupial160 .00XP_001363889.118753.80\%60.50\%PhascolarctoscinereusKoalaMarsupial160.00XP_020851162.118753.10\%60.20\%OrnithorhynchusanatinusPlatypusMonotreme180.00XP_016082126.221633.90\%40.40\% Clinical significance In research, the sequence has been identified as containing a possible pathogenic recessive variant (K53N) for various intellectual disabilities among 31 others.. The protein is suspected to be an adaptor/cofactor that binds to other molecules. In this case a non-homologous substitution could change binding to other molecules and potentially cause intellectual disability, inguinal hernia, frontal upsweep of hair, macrotia, high palate, hypertonia, hyperreflexia, abnormality of the cerebrum, or vitamin D deficiency
R
Location
location
R
Structure
structure
R
Structure
structure
R
Level Regulation
level regulation
R
Translational Modifications
translational modifications
R
Evolution
and evolution
R
GroupDate of Divergence
groupDate of divergence
R
NumberSequence
numberSequence
R
Sequency
Sequence
R
Similarity
similarity
R
LionCarnivora94XP
lionCarnivora94XP
R
LupisfamiliarisDogCarnivora94XP
lupusfamiliarisDogCarnivora94XP
R
Ungulate94XP
ungulate94XP
R
Flying FoxChiroptera94XP
flying foxChiroptera94XP
R
White-Sided DolphinArtiodactyla94XP
white-sided dolphinArtiodactyla94XP
R
DasypusnovemcinctusNine-Banded ArmadilloCingulata102XP
DasypusnovemcinctusNine-banded armadilloCingulata102XP
R
Short-Tailed OpossumMarsupial160
short-tailed opossumMarsupial160
R
Significance
significance