MS is an autoimmune disease of the central nervous system where the body attacks the fatty myelin which helps nerves carry electrical signals, causing muscle weakness and spasming which may lead to disability. MS affects approximately one of every 1000 people in North America, northern Europe and Australasia. The study, led by Drs. Samuel Weiss and V. Wee Yong of the Hotchkiss Brain Institute, compared virgin and pregnant mice with MS-like lesions introduced by lysolecithin, a chemical which destroys the myelin sheaths around neurons. They found the pregnant mice developed smaller lesions and fewer damaged neurons, and showed signs of repaired neurons. They also found the pregnant mice had higher levels of cells called oligodendrocytes, which create myelin and are able to repair some damaged neurons through reymyelination . Because prolactin regulates the levels of precursors of oligodendrocytes, the scientists hypothesized that prolactin levels were responsible for the differences in damage. They also tested virgin mice given additional prolactin, and found results similar to pregnant mice. MS causes lesions on neurons in the central nervous system. This image shows the progression of the lesions (white spots) on the brain over the course of a year. Photo credit: U.S. Brookhaven National Laboratory. Previous studies have shown that other hormones could reduce myelin damage, but this is the first study to show a mechanism to reverse myelin damage, and establish an empirical connection between that mechanism and pregnancy. Dr. Weiss says, “It is thought that during pregnancy, women’s immune systems no longer destroyed the myelin. However, no previous study has tested whether pregnancy actually results in the production of new myelin, which may lead to improvement of symptoms. "We're excited about this result because it suggests to us that prolactin has the potential to be used to enhance the production of new myelin.” Funding and support were provided by the Canadian Institutes of Health Research and the Multiple Sclerosis Society of Canada, the Alberta Heritage Foundation for Medical Research and the Stem Cell Network   .
 The study, led by Drs. Samuel Weiss and V. Wee Yong of the Hotchkiss Brain Institute, compared virgin and pregnant mice with MS-like lesions introduced by lysolecithin, a chemical which destroys the myelin sheaths around neurons. They found the pregnant mice developed smaller lesions and fewer damaged neurons, and showed signs of repaired neurons. They also found the pregnant mice had higher levels of cells called oligodendrocytes, which create myelin and are able to repair some damaged neurons through remyelination . Because prolactin regulates the levels of precursors of oligodendrocytes, the scientists hypothesized that prolactin levels were responsible for the differences in damage. They also tested virgin mice given additional prolactin, and found results similar to pregnant mice. MS causes lesions on neurons in the brain and spinal cord. These brain images show the progression of the lesions (white spots) on the brain over the course of a year. Photo credit: U.S. Brookhaven National Laboratory. Previous studies have shown that other hormones could reduce myelin damage, but this is the first study to show a mechanism to reverse myelin damage, and establish an empirical connection between that mechanism and pregnancy. Dr. Weiss says, “It is thought that during pregnancy, women’s immune systems no longer destroyed the myelin. However, no previous study has tested whether pregnancy actually results in the production of new myelin, which may lead to improvement of symptoms. "We're excited about this result because it suggests to us that prolactin has the potential to be used to enhance the production of new myelin.” Funding and support were provided by the Canadian Institutes of Health Research and the Multiple Sclerosis Society of Canada, the Alberta Heritage Foundation for Medical Research and the Stem Cell Network . MS is an autoimmune disease of the central nervous system where the body attacks the fatty myelin which helps nerves carry electrical signals, causing muscle weakness and spasming which may lead to disability. MS affects approximately one of every 1000 people in North America, northern Europe and Australasia .
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MS is an autoimmune disease of the central nervous system where the body attacks the fatty myelin which helps nerves carry electrical signals, causing muscle weakness and spasming which may lead to disability. MS affects approximately one of every 1000 people in North America, northern Europe and Australasia.
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reymyelination
remyelination
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central nervous system. This image shows
brain and spinal cord. These brain images show
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MS is an autoimmune disease of the central nervous system where the body attacks the fatty myelin which helps nerves carry electrical signals, causing muscle weakness and spasming which may lead to disability. MS affects approximately one of every 1000 people in North America, northern Europe and Australasia