All RhD negative pregnant women should receive RhoGam at 28 weeks gestation and within 72 hours after childbirth in addition to doses with any sensitizing event (miscarriage, trauma, bleeding). Most RhD mediated disease can be prevented if this is done. There are theories as to why or how this works, but none have been proven definitively to be the case. In addition, there has been research into finding a non-human derived version of this antibody, but none have been as effective as the currently available human derived formulations .
In an RhD negative mother, Rho(D)_immune_globulin can prevent temporary sensitization of the maternal immune system to RhD antigens, which can cause rhesus disease in the current or in subsequent pregnancies. With the widespread use of RhIG, Rh disease of the fetus and newborn has almost disappeared in the developed world. The risk that an RhD negative mother can be alloimmunized by a RhD positive fetus can be reduced from approximately 16\% to less than 0.1\% by the appropriate administration of RhIG .
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All RhD negative pregnant women should receive RhoGam at 28 weeks gestation and within 72 hours after childbirth in addition to doses with any sensitizing event (miscarriage, trauma, bleeding). Most RhD mediated disease can be prevented if this is done. There are theories as to why or how this works, but none have been proven definitively to be the case. In addition, there has been research into finding a non-human derived version of this antibody, but none have been as effective as the currently available human derived formulations
In an RhD negative mother, Rho(D)_immune_globulin can prevent temporary sensitization of the maternal immune system to RhD antigens, which can cause rhesus disease in the current or in subsequent pregnancies. With the widespread use of RhIG, Rh disease of the fetus and newborn has almost disappeared in the developed world. The risk that an RhD negative mother can be alloimmunized by a RhD positive fetus can be reduced from approximately 16\% to less than 0.1\% by the appropriate administration of RhIG