 Multiplexing and routing Some neurons, sometimes called resonators, exhibit sensitivity for specific input frequencies and fire either more quickly or exclusively when stimulated at that frequency. Intrinsically bursting neurons can use this band-pass filtering effect in order to encode for specific destination neurons and multiplex signals along a single axon. More generally, due to short-term synaptic depression and facilitation specific synapses can be resonant for certain frequencies and thus become viable specific targets for bursting cells  .
Synaptic plasticity Synaptic strengths between neurons follow changes that depend on spike timing and bursting. For excitatory synapses of the cortex, pairing an action potential in the pre-synaptic neuron with a burst in the post-synaptic neuron leads to long-term potentiation of the synaptic strength, while pairing an action potential in the pre-synaptic neuron with a single spike in the post-synaptic neuron leads to long-term depression of the synaptic strength. Such dependence of synaptic plasticity on the spike timing patterns is referred to as burst-dependent plasticity. Burst-dependent plasticity is observed with variations in multiple areas of the brain. Multiplexing and routing Some neurons, sometimes called resonators, exhibit sensitivity for specific input frequencies and fire either more quickly or exclusively when stimulated at that frequency. Intrinsically bursting neurons can use this band-pass filtering effect in order to encode for specific destination neurons and multiplex signals along a single axon. More generally, due to short-term synaptic depression and facilitation specific synapses can be resonant for certain frequencies and thus become viable specific targets for bursting cells . When combined with burst-dependent long-term plasticity, such multiplexing can allow neurons to coordinate synaptic plasticity across hierarchical networks .
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Synaptic plasticity Synaptic strengths between neurons follow changes that depend on spike timing and bursting. For excitatory synapses of the cortex, pairing an action potential in the pre-synaptic neuron with a burst in the post-synaptic neuron leads to long-term potentiation of the synaptic strength, while pairing an action potential in the pre-synaptic neuron with a single spike in the post-synaptic neuron leads to long-term depression of the synaptic strength. Such dependence of synaptic plasticity on the spike timing patterns is referred to as burst-dependent plasticity. Burst-dependent plasticity is observed with variations in multiple areas of the brain.
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. When combined with burst-dependent long-term plasticity, such multiplexing can allow neurons to coordinate synaptic plasticity across hierarchical networks