Exercise-induced collapse (EIC)    is a genetic syndrome, predominantly occurring in several retriever breeds as well as purebred Labrador Retrievers but also seen in Chesapeake Bay Retrievers and Curly Coated Retrievers, Boykin Spaniels, Cocker spaniels, German wire-haired pointers, Old English Sheepdogs, Bouvier des Flandres, Pembroke Welsh Corgis and Clumber Spaniels (verified 2015 by Laboklin in the UK). The syndrome was first positively identified by DNA in Boykin Spaniels in 2010. Before this, EIC episodes may have been misdiagnosed as heat stroke.%DIFDELCMD < %DIFDELCMD < %%% Affected dogs show signs of muscle weakness, loss of coordination, severe marked increase in body temperature and life-threatening collapse when participating in strenuous exercise or activity. Affected dogs can tolerate mild to moderate exercise, but short periods of strenuous activity, or even extreme excitement such as that seen in field trials or hunt tests, can induce weakness or collapse. Dogs affected with EIC usually cannot continue with intense retriever training, but can live normal lives as house pets. EIC is being observed with increasing frequency, either from the genetics becoming more widespread or from previously misdiagnosed cases being correctly identified now that there is evidence in the form of a DNA test. Dogs that have EIC are prone to mild to severe collapse that can range from dragging of the hind legs to complete collapse. Most affected dogs have been from field-trial breedings. Signs are initially noted in young dogs as they enter heavy training, which is usually between 5 months and 7 years of ageas stated in the initial UMN study in URL Dogs of either sex can be affected. Dogs with this condition are always normal at rest and are usually described as being extremely fit, prime athletic specimens of their breed.  [     ]   Through grants from the AKC CHF a patented DNA test was developed by the University of MN. The Orthopedic Foundation for Animals provides a public database for those dogs that are DNA tested. 
Exercise-induced collapse (EIC) Is a genetic disorder that causes dogs of certain breeds to collapse after a period of intense exercise. The breeds affected are primarily sporting dogs (retrievers, spaniels). Description Exercise-induced collapse (EIC) is a genetic disorder, mainly found in Labrador Retrievers , Chesapeake Bay Retrievers , Curly Coated Retrievers, and Boykin Spaniels. The genetic mutation has also been seen in a few cases in Cocker spaniels, German wire-haired pointers, Old English Sheepdogs, Bouvier des Flandres, Pembroke Welsh Corgis and Clumber Spaniels %DIFDELCMD < %DIFDELCMD < %%% . Signs are most likely to first become apparent in young dogs when they enter heavy training, which is usually between 5 months and 1 year of age. Dogs of either sex can be affected. Dogs with this condition are always normal at rest and are described as being extremely fit, prime athletic specimens of their breed. Dogs affected with this have no problem with regular exercise. The collapse occurs only with very strenuous exercise such as retrieving or participating in trials. Added excitement coincidental with the heavy exercise is more likely to bring on the collapse. Not all dogs with the disorder have an episode each time they exercise. It appears that the condition is more likely to occur with warmer temperatures. The lives of dogs with EIC are normal if extreme exercise is avoided. Symptoms and diagnosis During collapse the dog’s hind legs become weak until they are no longer able to support the dog’s weight. In the most extreme cases the dog’s front legs also go weak and the dog collapses, its leg muscles loose.[3 The episode generally lasts no more than 15 minutes over which time the dog returns to normal. The dog does not appear to be in pain during the collapse. Physiological systems (nervous system, cardiovascular and musculoskeletal systems) all appear normal in these dogs, as is a blood analysis both apart from and during an episode of collapse. Although tests have revealed elevated body temperature during collapse (average 107.1F (41.7C), many up to 108F (42.2C)), these temperatures are no different to those in normal dogs who have undertaken the same level of exercise. Research Research into the condition has been done at the Western College of Veterinary Medicine at the University of Saskatchewan, the College of Veterinary Medicine at the University of Minnesota, and the Comparative Neuromuscular Laboratory at the School of Medicine of the University of California. The cause has been identified as a mutation is in the gene for dynamin-1 (DNM1). This gene is a protein that plays a key role in repackaging synaptic vesicles containing neurotransmitters. The action of DNM1 is only triggered with a high level of sustained exercise when it is needed for synaptic transmission in the brain and spinal cord. The gene is recessive and for the dog to exhibit the exercise-induced collapse it must have two copies of the gene. 4] Nearly 40\% of all Labrador retrievers that were tested for the gene between 2008 and 2017 were carriers, meaning they had one copy of the mutation. Approximately 6\% had two copies of the gene and therefore had the potential to exhibit the collapse during exercise. There has been widespread testing and selective breeding in the years since the test for EIC was developed which has led to a decline in EIC in Labrador retrievers. Testing Through grants from the AKC CHF a patented DNA test was developed by the University of MN. The Orthopedic Foundation for Animals provides a public database for those dogs that are DNA tested. Other collapse disorders
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Is a genetic disorder that causes dogs of certain breeds to collapse after a period of intense exercise. The breeds affected are primarily sporting dogs (retrievers, spaniels).
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Description
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Exercise-induced collapse (EIC)
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syndrome, predominantly occurring in several retriever breeds as well as purebred Labrador Retrievers but also seen in
disorder, mainly found in Labrador Retrievers ,
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and
,
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Boykin Spaniels,
and Boykin Spaniels. The genetic mutation has also been seen in a few cases in
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(verified 2015 by Laboklin in the UK).
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The syndrome was first positively identified by DNA in Boykin Spaniels in 2010. Before this, EIC episodes may have been misdiagnosed as heat stroke.
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Affected dogs show signs of muscle weakness, loss of coordination, severe marked increase in body temperature and life-threatening collapse when participating in strenuous exercise or activity. Affected dogs can tolerate mild to moderate exercise, but short periods of strenuous activity, or even extreme excitement such as that seen in field trials or hunt tests, can induce weakness or collapse. Dogs affected with EIC usually cannot continue with intense retriever training, but can live normal lives as house pets.
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EIC is being observed with increasing frequency, either from the genetics becoming more widespread or from previously misdiagnosed cases being correctly identified now that there is evidence in the form of a DNA test. Dogs that have EIC are prone to mild to severe collapse that can range from dragging of the hind legs to complete collapse. Most affected dogs have been from field-trial breedings. Signs are initially noted
. Signs are most likely to first become apparent
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as
when
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7 years of ageas stated in the initial UMN study in URL
1 year of age.
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usually
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Dogs affected with this have no problem with regular exercise. The collapse occurs only with very strenuous exercise such as retrieving or participating in trials. Added excitement coincidental with the heavy exercise is more likely to bring on the collapse. Not all dogs with the disorder have an episode each time they exercise. It appears that the condition is more likely to occur with warmer temperatures. The lives of dogs with EIC are normal if extreme exercise is avoided.
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Symptoms and diagnosis During collapse the dog’s hind legs become weak until they are no longer able to support the dog’s weight. In the most extreme cases the dog’s front legs also go weak and the dog collapses, its leg muscles loose.
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3
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The episode generally lasts no more than 15 minutes over which time the dog returns to normal. The dog does not appear to be in pain during the collapse.
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Physiological systems (nervous system, cardiovascular and musculoskeletal systems) all appear normal in these dogs, as is a blood analysis both apart from and during an episode of collapse. Although tests have revealed elevated body temperature during collapse (average 107.1F (41.7C), many up to 108F (42.2C)), these temperatures are no different to those in normal dogs who have undertaken the same level of exercise.
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Research Research into the condition has been done at the Western College of Veterinary Medicine at the University of Saskatchewan, the College of Veterinary Medicine at the University of Minnesota, and the Comparative Neuromuscular Laboratory at the School of Medicine of the University of California. The cause has been identified as a mutation is in the gene for dynamin-1 (DNM1). This gene is a protein that plays a key role in repackaging synaptic vesicles containing neurotransmitters. The action of DNM1 is only triggered with a high level of sustained exercise when it is needed for synaptic transmission in the brain and spinal cord.
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The gene is recessive and for the dog to exhibit the exercise-induced collapse it must have two copies of the gene.
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4
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Nearly 40\% of all Labrador retrievers that were tested for the gene between 2008 and 2017 were carriers, meaning they had one copy of the mutation. Approximately 6\% had two copies of the gene and therefore had the potential to exhibit the collapse during exercise. There has been widespread testing and selective breeding in the years since the test for EIC was developed which has led to a decline in EIC in Labrador retrievers.
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Testing
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Other collapse disorders