Role in SARS-CoV-2 infection (COVID-19) The host-cell-expressed basigin (CD147) may bind spike protein of SARS-CoV-2 and possibly be involved in host cell invasion. Consequently , meplazumab, a humanized anti-CD147 antibody, has been tested in patients with SARS-CoV-2 pneumonia. The exact role and significance of basigin in COVID-19 is still unknown (as of March 2020) .
Role in SARS-CoV-2 infection (COVID-19) The host-cell-expressed basigin (CD147) may bind spike protein of SARS-CoV-2 and possibly be involved in host cell invasion. Subsequently , meplazumab, a humanized anti-CD147 antibody, was tested in patients with SARS-CoV-2 pneumonia. However, some of these claims have been challenged by another group of scientists who found no role for basigin in either binding the viral spike protein or promoting lung cell infection .
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The exact role and significance of basigin in COVID-19 is still unknown (as of March 2020)
However, some of these claims have been challenged by another group of scientists who found no role for basigin in either binding the viral spike protein or promoting lung cell infection