Autologous matrix-induced chondrogenesis (AMIC) is a trade mark owned by Geistlich Pharma, and relates only to the use of their product. The term Autologous Matrix Induced Chondrogenesis is however used by surgeons to generally describe a procedure using a material to enhance the natural healing process that microfracture affords. The procedure described below relates specifically to the use of a collagen membrane, but recent advances now allow the use, using the same surgical procedure of non woven bio - degradable materials that were initially developed for cell culturing of chondrocytes to be employed. These purely synthetic materials ( contain no animal derived products) are often further enhanced by impregnation of the material with high concentrations of Hyaluronic acid, which has been shown to be required to stimulate the differentiation of stem cells migrating from the bone marrow into chondrocytes (the true cartilage cell) and the resultant synthesis of type 2 collagen - the same native collagen found in the undamaged cartilage tissue. These enhanced synthetic bio - degradable materials have been successfully used to treat lesions in the Knee, Ankle, Hip and Great toe. Studies following the progress of knee patients have shown significant and persistent recovery following treatment (current study; 5 years, 2013). articular cartilage damage. There is tentative short to medium term benefits of the material described below as of 2017. It combines microfracture surgery with the application of a bi-layer collagen I/III membrane. __TOC__ Procedure A critical phase and actually essential requirement for satisfying outcome of the AMIC surgery is the compliance to a strict physical therapy program. Guidelines and recommendations exist, though they have to be adapted to the individual patients needs. History The AMIC procedure was first proposed by Behrens in 2003.  Its clinical efficiency in autologous chondrocyte implantation (ACI), another cartilage repair technique for larger cartilage lesions, has been studied.  Microfracture surgery was developed by Dr. Steadman in the late 1980s and early 1990s . It is a well documented cartilage repair technique and first line treatment option for small cartilage lesions. AMIC evolved with the aim to improve some of the shortfalls of microfracture surgery as for instance variable repair cartilage volume and functional deterioration over time. References 
Autologous matrix-induced chondrogenesis (AMIC) is a treatment for articular cartilage damage. It combines microfracture surgery with the application of a bi-layer collagen I/III membrane. There is tentative short to medium term benefits as of 2017. The initialism AMIC, often used as a genericized trademark, is a registered trademark of Ed. Geistlich Söhne AG, protected by German Registration No. 30255356 and international Registration No. 840373. The procedure described below relates specifically to the use of a collagen membrane, but recent advances now allow the use, using the same surgical procedure of non woven bio degradable materials that were initially developed for cell culturing of chondrocytes to be employed. These purely synthetic materials ( contain no animal derived products) are often further enhanced by impregnation of the material with high concentrations of Hyaluronic acid, which has been shown to be required to stimulate the differentiation of stem cells migrating from the bone marrow into chondrocytes (the true cartilage cell) and the resultant synthesis of type 2 collagen , the same native collagen found in the undamaged cartilage tissue. These enhanced synthetic biodegradable materials have been used to treat lesions in the knee, ankle, hip and great toe. Procedure An essential requirement for satisfying outcome of the AMIC surgery is the compliance to a strict physical therapy program. Guidelines and recommendations exist, though they have to be adapted to the individual patients needs. History The AMIC procedure was first proposed by Behrens in 2003. it aims to extend the use of microfracture surgery to larger cartilage lesions > 2.5 cm2.ref name="Behrens"></ref> Its clinical efficiency in autologous chondrocyte implantation (ACI), another cartilage repair technique for larger cartilage lesions, has been studied. The basic procedure of Microfracture surgery was developed by JR Steadman in the late 80’s and early 90’s . It is a well documented cartilage repair technique and first line treatment option for small cartilage lesions. AMIC evolved with the aim to improve some of the shortfalls of microfracture surgery as for instance variable repair cartilage volume and functional deterioration over time. References External links
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trade mark owned by Geistlich Pharma, and relates only to the use of their product.
treatment for articular cartilage damage. It combines microfracture surgery with the application of a bi-layer collagen I/III membrane. There is tentative short to medium term benefits as of 2017.
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term Autologous Matrix Induced Chondrogenesis is however used by surgeons to generally describe a procedure using a material to enhance the natural healing process that microfracture affords.
initialism AMIC, often used as a genericized trademark, is a registered trademark of Ed. Geistlich Söhne AG, protected by German Registration No. 30255356 and international Registration No. 840373.
D
-
R
-
,
R
bio - degradable
biodegradable
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successfully
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Knee, Ankle, Hip and Great toe. Studies following the progress of knee patients have shown significant and persistent recovery following treatment (current study; 5 years, 2013).
knee, ankle, hip and great toe.
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articular cartilage damage. There is tentative short to medium term benefits of the material described below as of 2017.
D
It combines microfracture surgery with the application of a bi-layer collagen I/III membrane. __TOC__
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A critical phase and actually
An
A
it aims to extend the use of microfracture surgery to larger cartilage lesions > 2.5 cm2.ref name="Behrens"></ref>
A
The basic procedure of
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Dr.
JR
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1980s and early 1990s
80’s and early 90’s
A
External links