# อินดิเพนเดนต์สปิริตอะวอร์ด สาขานักแสดงนำหญิงยอดเยี่ยม
– นักแสดงนำหญิงยอดเยี่ยม – เป็นหนึ่งในรางวัลที่มอบแก่นักแสดงหญิงประจำปี โดยฟิล์มอินดิเพนเดนท์สปิริตอะวอร์ด

ณ ปีค.ศ. 2017 นักแสดงหญิง Frances McDormand และ Julianne Moore ได้รับรางวัล 2 ครั้ง มากที่สุดในประเภทนี้ และ Michelle Williams ได้รับการเสนอชื่อเข้าชิงรางวัลมากที่สุด 4 ครั้ง ในประเภทนี้

สัญลักษณ์ในตาราง
 "†" หมายถึง ผู้มีผลงานได้รับรางวัลออสการ์ ด้วย
 "‡" หมายถึง ผู้ที่ได้รับการเสนอชื่อเข้าชิงรางวัลออสการ์ ด้วย

ผู้ชนะและได้รับการเสนอชื่อ
ปี 1985-1989
ปีนักแสดงภาพยนตร์บทบาท1985Geraldine PageThe Trip to BountifulCarrie Watts †Rosanna Arquette  After HoursMarcy FranklinLaura Dern  Smooth TalkConnie WyattLori Singer  Trouble in MindGeorgia1986Isabella RosselliniBlue VelvetDorothy VallensElpidia Carrillo  SalvadorMaríaPatricia Charbonneau  Desert HeartsCay RivversLaura Dern  Blue VelvetSandy WilliamsTracy Camilla Johns  She's Gotta Have ItNola Darling1987Sally KirklandAnnaAnna ‡Lillian Gish  The Whales of AugustSarah WebberDebra Sandlund  Tough Guys Don't DancePatty LareineLouise Smith  Working GirlsMollyJoanne Woodward  The Glass MenagerieAmanda Wingfield1988Jodie FosterFive CornersLindaRicki Lake  HairsprayTracy TurnbladNobu McCarthy  The WashMasi MatsumotoJulia Roberts  Mystic PizzaDaisy ArujoMeg Ryan  Promised LandBev Sykes1989Andie MacDowellSex, Lies, and VideotapeAnn Bishop MullanyYouki Kudoh  Mystery TrainMitsukoKelly Lynch  Drugstore CowboyDianneWinona Ryder  HeathersVeronica SawyerAnnabella Sciorra  True LoveDonna

ปี 1990-1999 
ปีนักแสดงภาพยนตร์บทบาท1990Anjelica HustonThe GriftersLilly Dillon ‡Mary Alice  To Sleep with AngerSuzieEszter Balint  Bail JumperElaineCarolyn Farina  MetropolitanAudrey RougetJoanne Woodward  Mr. and Mrs. BridgeIndia Bridge ‡1991Judy DavisImpromptuGeorge Sand / AuroraPatsy Kensit  Twenty-OneKatieMimi Rogers  The RaptureSharonLili Taylor  Bright AngelLucyLily Tomlin  The Search for Signs of Intelligent Life in the UniverseVarious Characters1992Fairuza BalkGas Food LodgingShadeEdie Falco  Laws of GravityDeniseCatherine Keener  Johnny SuedeYvonneSheryl Lee  Twin Peaks: Fire Walk with MeLaura PalmerCynda Williams  One False MoveLila "Fantasia" Walker1993Ashley JuddRuby in ParadiseRuby Lee GissingSuzy Amis Cameron  The Ballad of Little JoJosephine "Jo" MonaghanMay Chin  The Wedding BanquetWei-WeiAriyan A. Johnson  Just Another Girl on the I.R.T.Chantel MitchellEmma Thompson  Much Ado About NothingBeatrice1994Linda FiorentinoThe Last SeductionBridget Gregory / Wendy KroyJennifer Jason Leigh  Mrs. Parker and the Vicious CircleDorothy ParkerKaren Sillas  What Happened Was...Jackie MarshLauren Vélez  I Like It Like ThatLisette LinaresJacklyn Wu  Eat Drink Man WomanJia-Chien1995Elisabeth ShueLeaving Las VegasSera ‡Jennifer Jason Leigh  GeorgiaSadie FloodElina Löwensohn  NadjaNadjaJulianne Moore  SafeCarol WhiteLili Taylor  The AddictionKathleen Conklin1996Frances McDormandFargoMarge Gunderson †María Conchita Alonso  CaughtBettyScarlett Johansson  Manny & LoMannyCatherine Keener  Walking and TalkingAmeliaRenée Zellweger  The Whole Wide WorldNovalyne Price1997Julie ChristieAfterglowPhyllis Mann ‡Stacy Edwards  In the Company of MenChristineAlison Folland  All Over MeClaudeLisa Harrow  SundayMadeleine VeseyRobin Wright  LovedHedda Amerson1998Ally SheedyHigh ArtLucy BerlinerKatrin Cartlidge  Claire DolanClaire DolanChristina Ricci  The Opposite of SexDede TruittRobin Tunney  Niagara, NiagaraMarcyAlfre Woodard  Down in the DeltaLoretta Sinclair1999Hilary SwankBoys Don't CryBrandon Teena †Diane Lane  A Walk on the MoonPearl KantrowitzJanet McTeer  TumbleweedsMary Jo Walker ‡Susan Traylor  Valerie FlakeValerie FlakeReese Witherspoon  ElectionTracy Flick

ปี 2000-2009
ปีนักแสดงภาพยนตร์บทบาท2000Ellen BurstynRequiem for a DreamSara Goldfarb ‡Joan Allen  The ContenderLaine Hanson ‡Sanaa Lathan  Love & BasketballMonica WrightLaura Linney  You Can Count On MeSamantha "Sammy" Prescott ‡Kelly Macdonald  Two Family HouseMary O'Neary2001Sissy SpacekIn the BedroomRuth Fowler ‡Kim Dickens  Things Behind the SunSherryMolly Parker  The Center of the WorldFlorenceTilda Swinton  The Deep EndMargaret HallKerry Washington  LiftNiecy2002Julianne MooreFar from HeavenCathy Whitaker ‡Jennifer Aniston  The Good GirlJustine LastMaggie Gyllenhaal  SecretaryLee HollowayCatherine Keener  Lovely & AmazingMichelle MarksParker Posey  Personal VelocityGreta Herskowitz2003Charlize TheronMonsterAileen Wuornos †Agnes Bruckner  Blue CarMegan DenningZooey Deschanel  All the Real GirlsNoelSamantha Morton  In AmericaSarah ‡Elisabeth Moss  VirginJessie Reynolds2004Catalina Sandino MorenoMaria Full of GraceMaría Álvarez ‡Kimberly Elise  Woman Thou Art LoosedMichelle JordanVera Farmiga  Down to the Bone  Irene MorrisonJudy Marte  On the OutsOzKyra Sedgwick  CavedwellerDelia Byrd2005Felicity HuffmanTransamericaBree ‡Dina Korzun  Forty Shades of BlueLauraLaura Linney  The Squid and the WhaleJoan BerkmanS. Epatha Merkerson  Lackawanna BluesRachel "Nanny" CrosbyCyndi Williams  RoomJulia Barker2006Shareeka EppsHalf NelsonDreyCatherine O'Hara  For Your ConsiderationMarilyn HackElizabeth Reaser  Sweet LandYoung IngeMichelle Williams  Land of PlentyLanaRobin Wright  Sorry, HatersPhoebe Torrence2007Ellen PageJunoJuno MacGuff ‡Angelina Jolie  A Mighty HeartMariane PearlSienna Miller  InterviewKatyaParker Posey  Broken EnglishNora WilderTang Wei  Lust, CautionWong Chia Chi / Mak Tai Tai2008Melissa LeoFrozen RiverRay Eddy ‡Summer Bishil  TowelheadJasira MarounAnne Hathaway  Rachel Getting MarriedKym Buchman ‡Tarra Riggs  BallastMarleeMichelle Williams  Wendy and LucyWendy Carroll2009Gabourey SidibePreciousClaireece "Precious" Jones ‡Maria Bello  Downloading NancyNancy StockwellNisreen Faour  AmreekaMuna FarahHelen Mirren  The Last StationSophia Tolstaya ‡Gwyneth Paltrow  Two LoversMichelle Rausch

ปี 2010-2019
ปี นักแสดง ภาพยนตร์ บทบาท 2010  Natalie Portman  Black Swan  Nina Sayers †Annette Bening  The Kids Are All Right  Nicole "Nic" Allgood ‡Greta Gerwig  Greenberg  Florence MarrNicole Kidman  Rabbit Hole  Becca Corbett ‡Jennifer Lawrence  Winter's Bone  Ree Dolly ‡Michelle Williams  Blue Valentine Cindy Heller ‡ 2011  Michelle Williams  My Week with Marilyn Marilyn Monroe ‡Lauren Ambrose  About Sunny AngelaRachael Harris  Natural Selection Linda WhiteAdepero Oduye  Pariah AlikeElizabeth Olsen  Martha Marcy May Marlene Martha 2012  Jennifer Lawrence  Silver Linings Playbook  Tiffany Maxwell †Linda Cardellini  Return  KelliEmayatzy Corinealdi  Middle of Nowhere  RubyQuvenzhané Wallis  Beasts of the Southern Wild  Hushpuppy ‡Mary Elizabeth Winstead  Smashed  Kate Hannah 2013  Cate Blanchett  Blue Jasmine  Jeanette "Jasmine" Francis †Julie Delpy  Before Midnight  Céline WallaceGaby Hoffmann  Crystal Fairy  Crystal FairyBrie Larson  Short Term 12  Grace HowardShailene Woodley  The Spectacular Now  Aimee Finecky 2014  Julianne Moore  Still Alice  Dr. Alice Howland †Marion Cotillard  The Immigrant  Ewa CybulskaRinko Kikuchi  Kumiko: The Treasure Hunter  KumikoJenny Slate  Obvious Child  Donna SternTilda Swinton  Only Lovers Left Alive  Eve 2015 Brie Larson Room  Joy "Ma" Newsome †Cate Blanchett  Carol  Carol Aird ‡Rooney Mara  Carol  Therese Belivet ‡Bel Powley  The Diary of a Teenage Girl  Minnie GoetzeKitana Kiki Rodriguez  Tangerine  Sin-Dee Rella 2016  Isabelle Huppert  Elle  Michèle Leblanc ‡Annette Bening  20th Century Women  Dorothea FieldsSasha Lane  American Honey  StarRuth Negga  Loving  Mildred Loving ‡Natalie Portman  Jackie  Jacqueline Kennedy Onassis ‡ 2017  Frances McDormand  Three Billboards Outside Ebbing, Missouri  Mildred Hayes †Salma Hayek  Beatriz at Dinner  BeatrizMargot Robbie  I, Tonya  Tonya Harding ‡Saoirse Ronan  Lady Bird  Christine "Lady Bird" McPherson ‡Shinobu Terajima  Oh Lucy!  Setsuko Kawashima / LucyRegina Williams  Life and Nothing More  Regina

ผู้ได้รับการเสนอชื่อหลายครั้ง

2 ครั้ง
 Annette Bening
 Cate Blanchett
 Laura Dern
 Brie Larson
 Jennifer Lawrence
 Jennifer Jason Leigh
 Laura Linney
 Frances McDormand
 Natalie Portman
 Parker Posey
 Tilda Swinton
 Lili Taylor
 Joanne Woodward
 Robin Wright

3 ครั้ง
 Catherine Keener
 Julianne Moore

4 ครั้ง
 Michelle Williams

ผู้ชนะหลายครั้ง
2 ครั้ง
 Frances McDormand
 Julianne Moore

ดูเพิ่ม
 Academy Award for Best Actress

 รางวัลลูกโลกทองคำ &nndash; Best Actress in a Motion Picture – Drama; Best Actress – Motion Picture Comedy or Musical