wanglab/gogpt-training-data huggingface dataset:
Protein: Target of rapamycin complex subunit lst8 (TORC subunit lst8) (P91040)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU369068}.
Interaction partners:
- RICTOR_N domain-containing protein
- Target of rapamycin homolog
- DAF-15
- Stress-activated map kinase-interacting protein 1 homolog
- GTP-binding protein
- GTP-binding protein Rheb homolog 1
- Ras-related GTP-binding protein C
- Autophagy-related protein 13 homolog
- Serine/threonine-protein phosphatase 4 regulatory subunit ppfr-4
- Serine/threonine-protein kinase smg-1
Sequence:
MRFKKLKNRQIFIFFKKYFMTPEKSFETEKHFQNTNQVPTEAPPSFDPSPHALLVSASYDLTIRLWQLSTGKCIGTIPHNEGQVNALSLTSTGRDLAVGAWQKVRIYDVSSGKDPKATIELPKNVTVVGFEAAGRWMYTGGDDGVCRIWEMRNNQLVANRLLSFPGSTVTSIVPNTHQTHLFVSTNSAHVWVWDVVNHIFMRLPMPDDLKMQEFVQKLAVHPSGKKLTGITNKGRLLCWDLMTREVVESSAFDMFKSPIVPIEQDTGTYGCLRDEDKHYKMREGHGLSCRYSPDGKYIVASGSEKEVYVFNSETMEIKGSLQTECGWNWDAIFSSEGRYIFTGGNDNQVKIWDVENNKKVAQWDGHIKPLTAMCMNGPTPPP
Protein: Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) (Calcium-response factor) (CaRF) (D4A7U2)
Organism: Rattus norvegicus (Rat)
Function: Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence.
Subcellular location: Nucleus {ECO:0000269|PubMed:11832226}.
Interaction partners:
- Carboxypeptidase A5
Sequence:
MLASSQMTSVSEEKPIGGSLPAVSTDALEDSASSYSLHSQASLVGPRKSGTRTLEEPLLAPLQPLSCNTPMWACRLRSCEKIGDSYRGYCVSETELESVLTFHKQQTQTVWGTRQSPSPAKPATRLMWKSQYVPYDGIPFVNAGSRAVVMECQYGPRRKGFQLKKISEQESRSCHLYKATCPARIYIKKVQKFPDYRVPTDPQIDRKTIRMEQEKAFTMLKKNLVDAGGVLRWYVQLPTQQAHQYHEPETPGVPLSPSPFPMSPLEEEEAIIRDENCVLPSRLHPQVAHKIQELVSQGVGQVYAVRKQLRKFVERELFKPDEVPERHNLSFFPTVNDIKNHIHEVQKSLQTGDVVYNSEIIPATLQWTTDSGNILRETVTVTFAEGNLLKEPITSKMGTSQTQTSLSPEPLPLLSPLSSFQPKIFTHLQALKLQPRLSSPDGSQALVSVNSHPSSSPPGLDTAGNAEANNHSLLLGQSQNLGTDTCLPENSSTASPMGSLPESVQNLVAVDQLVGGEDAEDAGNLEGNVKRTLLGDAHTIPIHILDSHPALVEEDTLSMNQVKQEPNEPTLSTEAKTLLDCKNVSAT
Protein: Aminopeptidase NAALADL1 (EC 3.4.11.-) (100 kDa ileum brush border membrane protein) (I100) (Ileal dipeptidylpeptidase) (N-acetylated-alpha-linked acidic dipeptidase-like protein) (NAALADase L) (Q9UQQ1)
Organism: Homo sapiens (Human)
Function: Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:O54697}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O54697}. Note=Ileal brush border membrane. {ECO:0000250|UniProtKB:O54697}.
Interaction partners:
- C-C chemokine receptor type 7
- Dipeptidyl peptidase 4
- Small conductance calcium-activated potassium channel protein 3
- Adhesion G-protein coupled receptor G6
- Ubiquitin carboxyl-terminal hydrolase isozyme L1
- T-cell surface glycoprotein CD4
- CD27 antigen
- T-cell surface glycoprotein CD8 alpha chain
- B-lymphocyte antigen CD19
Sequence:
MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIRENLRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIVGPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQGIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLPPSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNGTLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPDRYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFLQAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLMLLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQLSIVVTALEGAAATLRPVADL
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q9XTL3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVFIRDPCGIACLVVTYGAVLYADYVVIRWIILTTMPGSLWMSFHVVLFNTVVFLLAMSHSKAVFSDPGTVPLPANRLDFSDLHTTNKNNPPPGNGHSSEWTVCTRCETYRPPRAHHCRICKRCIRRMDHHCPWINNCVGERNQKYFLQFLIYVALLSLYSIALIVGSWVWPCEECSQNVIETQLRMIHSGYPYAGVRRCSACSLRPSWWTSCMRFCTTRRPWRRYSRRAPIVQIGASTSCWRMCSDADIRRCGCCPAPVSIMPPANHDTPLLSHEV
Protein: Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) (P67080)
Organism: Escherichia coli (strain K12)
Function: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. May have a carrier function to deliver PLP to the target enzymes or a protective function so that PLP does not inactivate essential lysines in proteins. Does not have amino acid racemase activity.
Interaction partners:
- Uncharacterized protein YggT
- UPF0235 protein YggU
- dITP/XTP pyrophosphatase
- Heme chaperone HemW
- Pyrroline-5-carboxylate reductase
- dTTP/UTP pyrophosphatase
- Purine nucleoside phosphorylase YfiH
- Pyridoxal kinase PdxY
- Pyridoxine/pyridoxal/pyridoxamine kinase
Sequence:
MNDIAHNLAQVRDKISAAATRCGRSPEEITLLAVSKTKPASAIAEAIDAGQRQFGENYVQEGVDKIRHFQELGVTGLEWHFIGPLQSNKSRLVAEHFDWCHTIDRLRIATRLNDQRPAELPPLNVLIQINISDENSKSGIQLAELDELAAAVAELPRLRLRGLMAIPAPESEYVRQFEVARQMAVAFAGLKTRYPHIDTLSLGMSDDMEAAIAAGSTMVRIGTAIFGARDYSKK
Protein: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (A0A023VTS2)
Organism: Sus scrofa (Pig)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
Sequence:
MQSADSQQPSKRPRRDGSPTTPPNTPPAAAERSLGPNLHPDHRTWGPEQVCGFLNRSGFGDSELLERCREKKITGSILPFLDESLLEDLGVSSYEKRMKLLNYIQRLGQTHVDTVKVINDPIHGHIELHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRELSEKQPELQISERDMLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPDVKWTHEQGSVNMFEHLVNSNGLIDVMEHYGLIPEEDIWFIKEQITGPLESPVKNATWPYKGRPKEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNKKHICTREKEVGNLYDMFHTRNCLHRRAYQHKVGNIIDTMITDAFLKADPYIEITGSEGKKYRISTAIDDMEAFTKLTDNIFLEILYSTDPKLDAARAILKKIECRNLYKFVGETQPGRQDKIKRENYESLPKGVASAKPSNIQLEAELKAEDFIVDVINMDYGMEDKNPIDNVRFYCKSDPNKAIIITKNQVSQLLPERFAEQLIRVYCKKTDEKSLFAARQHFVQWCLDNDFTKPQDGDVVAPLITPRKLEWNSTHSAQSQARTREASKSRVRLFAKDSV
Protein: E3 ubiquitin protein ligase RIN3 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RIN3) (RPM1-interacting protein 3) (Q8W4Q5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin protein ligase that acts as positive regulator of RPM1- and RPS2-dependent hypersensitive response (HR), in association with RIN2. Probably not required for RPM1 degradation during HR.
Subcellular location: Membrane {ECO:0000269|PubMed:16212605}; Multi-pass membrane protein {ECO:0000269|PubMed:16212605}.
Interaction partners:
- E3 ubiquitin protein ligase RIN2
- Disease resistance protein RPM1
- Protein OS-9 homolog
- RING-H2 finger protein ATL14
- RING-H2 finger protein ATL43
Sequence:
MGITYLHISVATTALSFVGLQVWTELSLDRLRADGIITKNISLGNSENTLELLLSSHTTIALLASFVLNIYILLVLSLKTLFFGDLYAIETRKLVERLANYIIYKGTFLPFVVPRTVFQGVLWTIWLTVLCTLKMFQALARDRLDRLNASPSSTPWTYFRVYSALFMVLSTDLCWIKLSLMIYNTVGSSVYLLLLFEPCGIAFETLQALLIHGFQLLDMWINHLAVKNSDCQRSKFYDSMTAGSLLEWKGLLNRNLGFFLDMATLVMALGHYLHIWWLHGMAFHLVDAVLFLNIRALLSSILKRIKGYIKLRVALGALHAALLDATSEELRDYDDECAICREPMAKAKRLHCNHLFHLGCLRSWLDQGLNEVYSCPTCRKPLFVGRTESEANPSRGEVSSDEHLARQFERQNNSVHALTTGMFPTETPNFTESDPWRNSEVDPSWLQTWSDQGVDVVGSSAGSRSVGLGQVQLMMRHLASVGEGSAQTTLDDASWGLWPMNPSQASTSSTYVPPGAGGRTGGLHLRTVSRAANNMASILAMAETVREVLPHVPDEIIFQDLQRTNSVSVTVNNLLQM
Protein: 11-oxo-beta-amyrin 30-oxidase (EC 1.14.14.115) (Cytochrome P450 72A63) (H1A981)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Involved in the biosynthesis of triterpenoid saponins. Catalyzes three sequential oxidation steps at C-30 of 11-oxo-beta-amyrin. Also able to catalyze sequential C-30 hydroxylation of beta-amyrin to produce 30-hydroxy-beta-amyrin and 11-deoxoglycyrrhetinic acid.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEVFMFPTGTTVIISVLSVLLAVIPWYLLNKLWLKPKRFEKLLKAQGFQGEPYNLSVLKDKSKQNYMLKLQQEDKSKSIGLSKEAAPSIFTPVHQTVRKYGNNSFLWEGTTPRVIITDPDQIKDVFNKIDDFPKPKLRSIAKYLSVGILDHEGKKWAKHRKIANPAFHLEKLKVMLPAFSHSCNEMISKWKELLSSDGTCEIDVWPSLQNFTCDVISRTAFGSSYAEGTKLFQLLKKQGFLLMTGRHTNNPLWGLLATTTKTKMKEIDREIHDSLEGIIEKREKALKNGETTNDDLLGILLQSNHAEKQGQGNSKNIGMTTQDVIDECKLFYLAGQETTSSLLVWTMVLLGRYPEWQARAREEVLQVFGNQNPNNEGLSQLKIVTMILYEVLRLFPPLIYFNRALRKDLKLGNLLLPEGTQISLPILLIHQDHDLWGDDAKEFKPERFAEGIAKATKGQVSYFPFGWGPRICLGQNFALLEAKIAVSLLLQNFSFELSPNYVHVPTTVLTLQPKNGASIILHKL
Protein: Cytochrome P450 1A4 (EC 1.14.14.1) (CYPIA4) (Cytochrome P450 TCDDAHH) (P79760)
Organism: Gallus gallus (Chicken)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- UDP-glucuronosyltransferase
- Epoxide hydrolase
- Uncharacterized protein.
- Cholesterol 7-alpha-monooxygenase
- Epoxide hydrolase 1
- Uncharacterized protein
- Cytochrome P450 1A5
- Catechol O-methyltransferase
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Aromatase
Sequence:
MAAGPQAAMEQASSPGLISATEVLVAAATFCLLLLLTQTRRQHAPKGLRSPPGPRGLPMLGNVLELRKDPHLVLTRLSRKYGDVMEVTIGSRPVVVLSGLETIKQALVRQAEDFMGRPDLPSWQYVSNGHSLAFSYECGDAWKARRKLAQNALKTFSIAASPTASSSCLLEEHVSTEASYLVTKFLQLMEEKQSFNPNSYLMVSVANVICAICFGKRYDHDDQELLSVVNMNTEFGDVAAAGNPADFIPLLRYLPNRAMAAFKDVNARFSAFVQKIVQNHYSTFDKEHIRDVTDSLIGHCQEKRTGEDVRVQPSDESIISIVNDLFGAGFDTVTTALSWCMMYAALYPHIQKKIQAELDQTIGRERRPRLSDRGMLPYTEAFILEAFRHSSLLPFTIPHCTTKDTVLNGYYIPKDTCVFINQWQANHDEKIWKDPPSFKPERFLNAAGTELSRTEADKVLIFGLGKRRCIGESIGRWEVFLFLTTILQQLEISLAPGQRVDITPQYGLTMKYKQCECFQMKKRFPSKGSA
Protein: Mitofusin-2 (EC 3.6.5.-) (Mitochondrial transmembrane GTPase FZO1A) (Protein HSG) (Transmembrane GTPase MFN2) (Q8R500)
Organism: Rattus norvegicus (Rat)
Function: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (By similarity). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:14561718, ECO:0000269|PubMed:15322553}; Multi-pass membrane protein {ECO:0000269|PubMed:14561718}. Note=Colocalizes with BAX during apoptosis. {ECO:0000250|UniProtKB:O95140}.
Interaction partners:
- Serine/threonine-protein kinase PINK1, mitochondrial
- E3 ubiquitin-protein ligase parkin
- Mitofusin-1
- E3 ubiquitin-protein ligase MARCHF5
- Mitochondrial fission 1 protein
- Mitochondrial antiviral-signaling protein
- Non-selective voltage-gated ion channel VDAC1
- Dynamin-like GTPase OPA1, mitochondrial
- Mitochondrial Rho GTPase 2
- Sequestosome-1
Sequence:
MSLLFSRCNSIVTVKKDKRHMAEVNASPLKHFVTAKKKINGIFEQLGAYIQESAGFLEDTHRNTELDPVTTEEQVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGTDGHEAFLLTEGSEEKKSVKTVNQLAHALHQDEQLHAGSLVSVMWPNSKCPLLKDGLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWDASASEPEYMEEVRRQHMERCTSFLVDELGVVDRAQAGDRIFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVRMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHIAAQEQRVYCLEMREERQDRLRFIDKQLELLAQDYKLRIKQMTEEVERQVSTAMAEEIRRLSVLVDEYQMDFHPSPVVLKVYKNELHRHIEEGLGRNMSDRCSTAIASSLQTMQQDMIDGLKPLLPVSVRNQIDMLVPRQCFSLSYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRALLGYNDQVQRPLPLTPANPSMPPLPQGSLTQEELMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTTRAKERAFKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKKVEALDSLQSKAKLLRNKAGWLDSELNMFIHQYLQPSR
Protein: Matrix protein 2 (Proton channel protein M2) (Q20MH8)
Organism: Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
Subcellular location: Virion membrane {ECO:0000256|HAMAP-Rule:MF_04069}. Host apical cell membrane {ECO:0000256|HAMAP-Rule:MF_04069}; Single-pass type III membrane protein {ECO:0000256|HAMAP-Rule:MF_04069}. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion). {ECO:0000256|HAMAP-Rule:MF_04069}.
Interaction partners:
Sequence:
MSLLTEVETPIRNEWGCRCNDSSDPLVIAANIIGILHLILWILDRLFFKCIYRRFKYGLKRGPSTEGVPESMREEYRKEQQNAVDVDDGHFVNIELE
Protein: Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) (Q80T91)
Organism: Mus musculus (Mouse)
Function: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10 (By similarity). {ECO:0000250}.
Interaction partners:
- Laminin subunit alpha-4
Sequence:
MAPSAVGLLVFLLQAALALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCADILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYENGDFCIPLCTEECMHGRCVSPDTCHCEPGWGGPDCSSGCDSEHWGPHCSNRCQCQNGALCNPITGACVCAPGFRGWRCEELCAPGTHGKGCQLLCQCHHGASCDPRTGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGTFGFLCSQRCDCHNGGQCSPATGACECEPGYKGPSCQERLCPEGLHGPGCTLPCPCDTENTISCHPVTGACTCQPGWSGHYCNESCPAGYYGNGCQLPCTCQNGADCHSITGSCTCAPGFMGEVCAVPCAAGTYGPNCSSVCSCSNGGTCSPVDGSCTCREGWQGLDCSLPCPSGTWGLNCNETCICANGAACSPFDGSCACTPGWLGDSCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSRGPCHHISGICECLPGFSGALCNQVCAGGHFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPSGFWGSACFHTCSCHNGASCSAEDGACHCTPGWTGLFCTQRCPSAFFGKDCGHICQCQNGASCDHITGKCTCRTGFSGRHCEQRCAPGTFGYGCQQLCECMNNATCDHVTGTCYCSPGFKGIRCDQAALMMDELNPYTKISPALGAERHSVGAVTGIVLLLFLVVVLLGLFAWRRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSDLSQSSSHAQCFSNASYHTLACGGPATSQASTLDRNSPTKLSNKSLDRDTAGWTPYSYVNVLDSHFQISALEARYPPEDFYIELRHLSRHAEPHSPGTCGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHLGSPYTDVPSLSTSNKNIYEVGRCLT
Protein: Iron(3+)-hydroxamate import system permease protein FhuB (Ferric hydroxamate uptake protein B) (Ferrichrome transport system permease protein FhuB) (Ferrichrome uptake protein FhuB) (Iron(III)-hydroxamate import system permease protein FhuB) (P06972)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:15919996}.
Interaction partners:
- Iron
- Iron
- Ferric enterobactin transport ATP-binding protein FepC
- Ferrichrome outer membrane transporter/phage receptor
- Fe
- Vitamin B12 import ATP-binding protein BtuD
- Vitamin B12-binding protein
- Vitamin B12 import system permease protein BtuC
- Spermidine/putrescine transport system permease protein PotC
- Spermidine/putrescine transport system permease protein PotB
Sequence:
MSKRIALFPALLLALLVIVATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFAAQAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLAIVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLLWLLPRLRSISAPDMKVNDRVAAERQHVLAFALAGGVLLLMAVVVALSFGRDAHGWTWASGALLEDLMPWRWPRIMAALFAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSLGAAVTLLIIMIAAGRGGFSPHRMLLAGMALSTAFTMLLMMLQASGDPRMAQVLTWISGSTYNATDAQVWRTGIVMVILLAITPLCRRWLTILPLGGDTARAVGMALTPTRIALLLLAACLTATATMTIGPLSFVGLMAPHIARMMGFRRTMPHIVISALVGGLLLVFADWCGRMVLFPFQIPAGLLSTFIGAPYFIYLLRKQSR
Protein: Spindle assembly checkpoint protein SLDB (C8VP05)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Uncharacterized protein
- Mitotic spindle checkpoint protein
- Anaphase-promoting complex subunit 4
- Protein bimA
- Cell division cycle protein Cdc20, putative
- Anaphase-promoting complex subunit 5
- Chromosome segregation protein Spc105, putative
- 20S cyclosome subunit
- C2H2 finger domain protein, putative
- 20S cyclosome subunit
Sequence:
MASNQFTITSPPTDAISALKFSPAPDSTRFVVSSWDKNVYVYDLRDENGAAGEGKLLQKFEHRAPVLDACFGATEDEIFTAGLDWDVKRIDIASASQTVLSSHDAGVRSVVYSKEYSMVISASWDNTLHVHRLAGDRSVTNTASIPLPSKPFSMSLTATKLVVGMASRALHIYDLKSLSLLTGQSEGGVAPAKVEVEPWQRRESSLKFMTRCVACMPDDAGYASSSIEGRVAVEWFDPSAESQARKYAFKCHRQTSDDVDVVYPVNSLAFHPIHGTFASGGGDGVVALWDGIAKRRIRQYQKYPSSVAAVAFSSNGKYLAIAISPGYEDGKDDLTDGTVRIYVRELGETEAKGKGAK
Protein: Condensin complex subunit 2 (P91663)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MTLPRLETPLRRSAVGSYQEGVSRMLTPFNDDEAERREARRRTLLQQHHRSSTLESIEDNETIKNCLELYNGNKVSKDNAWNLMLIDSLANLLDHHHKRMSNFKMAGSSLEASSKVYGLRVDSIYLDAMRISAGLSARTLTDKQINAAEDDDGPQGEQATGEGQDSAQQAAKEAAPKPKRQKKPISTVTKNRETLNSRLDTAPLQDPVFGKLNSTCGASINASNRLMHNILPSFDSELRLRTTYNFWNSEESTEEVQDHTTLNAEMEQWPATSLMSTNLMRKLLPHAERSNLRPLHTGYIITSAPNPKSANEKAAEVVQDEDHDEGLDNADDVCVNKISMAFDINAECEPMPDLDGPPPLVLEVDSNELEELTAEEQMVINNCRRLRKQTEFIEDLRPVDGNSKLEYSYRPMDQISQFWAGPSHWKFKRTRPRSTFSQTNGQVDTQPIRTQRAKKSAHLNANRRAKALDYGNVTENFFQQLDTTIRQRKANFQKKWDPRKLILPTKFELDPDLFFKYESAPSIKLSKRAGEPDSDEGGDLGIDMDADMHHDDDNDQELFNNEHFTDAVPANVSVIAAIAAEQAAEASMMNVSAGEIGLTQMNATCNNTVFEIGTEFEGAPSQVAKVIVPFAKRAKVIDMKNLKKSCNSLIQKQLLNAVPEETIPSHPKKKGEHYSKGFASFQQVYQKLPDLLTTKMSDSLSPSVAFYAVLHLANDLKLRLIPQEDLEDFQIRQVLD
Protein: Sulfotransferase 3, isoform B (EC 2.8.2.-) (B7YZP4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNRVQVTPRSYPTNLIDKDWGNRKLFYTKDSENFLRLVHDMKLRDDDVWIVTLPKCGTTWMQELLWLLLNNCDFEGALAKDQELRTPFLEFGYSVFHDPNRSFGPIEDLKSPRLIKSHLSLALLPSKLWEGKNKVIYVSRNPLDSYVSRYYHGVSFGFNYGKSLHQYFDEVLASDDFPTEFIEHAHEFYQLRNEPWVFYTSFEMMKKDLRGVINDVSRFLNKPINDQQMEKLLKHLSFAEMKKNPTTNHLWELAQVQHENAGKEMHPFVRRGDVNGYKDELKPEQIEKANVRIQEVLAKNGVTLDELLLLKDQ
Protein: Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) (O43426)
Organism: Homo sapiens (Human)
Function: Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O18964}.
Interaction partners:
- Endophilin-A1
- Amphiphysin
- Myc box-dependent-interacting protein 1
- Endophilin-A2
- Intersectin-1
- Inositol polyphosphate-4-phosphatase type I A
- Sorting nexin-9
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Growth factor receptor-bound protein 2
- Endophilin-A3
Sequence:
MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRESPLKIDPFEDLSFNLLAVSKAQLSVQTSPVPTPDPKRLIQLPSATQSNVLSSVSCMPTMPPIPARSQSQENMRSSPNPFITGLTRTNPFSDRTAAPGNPFRAKSEESEATSWFSKEEPVTISPFPSLQPLGHNKSRASSSLDGFKDSFDLQGQSTLKISNPKGWVTFEEEEDFGVKGKSKSACSDLLGNQPSSFSGSNLTLNDDWNKGTNVSFCVLPSRRPPPPPVPLLPPGTSPPVDPFTTLASKASPTLDFTER
Protein: Esterase OVCA2 (EC 3.1.2.-) (Ovarian cancer-associated gene 2 protein) (Q8WZ82)
Organism: Homo sapiens (Human)
Interaction partners:
- 2-
- 2-
Sequence:
MAAQRPLRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVPDPPGPEGARSDFGSCPPEEQPRGWWFSEQEADVFSALEEPAVCRGLEESLGMVAQALNRLGPFDGLLGFSQGAALAALVCALGQAGDPRFPLPRFILLVSGFCPRGIGFKESILQRPLSLPSLHVFGDTDKVIPSQESVQLASQFPGAITLTHSGGHFIPAAAPQRQAYLKFLDQFAE
Protein: Mitogen-activated protein kinase kinase kinase 16 (F4JVS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Regulator of chromosome condensation
- Regulator of chromosome condensation
Sequence:
MEINWTRGPIIGRGSTATVSIAISSSGELFAVKSADLSSSSLLQKEQSILSTLSSPHMVKYIGTGLTRESNGLVYNILMEYVSGGNLHDLIKNSGGKLPEPEIRSYTRQILNGLVYLHERGIVHCDLKSHNVLVEENGVLKIADMGCAKSVDKSEFSGTPAFMAPEVARGEEQRFPADVWALGCTMIEMMTGSSPWPELNDVVAAMYKIGFSGESPAIPAWISDKAKDFLKNCLKEDQKQRWTVEELLKHPFLDDDEESQTSDCLKNKTSSPSTVLDQRFWDSCESSKSHLVSIDHEDPFAEYSESLDSPADRIEKLAGDEFSSLLDWDTEDDGGWIQVRGEKHKETEKRDGDEDVICVEATSSSQTIEEVEDWISNQDSLFSEYSSDDIINNFYSNVAIQGNLIAFHYCTDEDENVSIKNMFRTNNKHLFFKLQAHVKFTNQV
Protein: Motilin receptor (G-protein coupled receptor 38) (O43193)
Organism: Homo sapiens (Human)
Function: Receptor for motilin.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Promotilin
- Appetite-regulating hormone
- Neurotensin/neuromedin N
Sequence:
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
Protein: Preprofallaxidin-2 [Cleaved into: Fallaxidin-3.1; Fallaxidin-3.2] (B5LUQ3)
Organism: Litoria fallax (Eastern dwarf tree frog) (Hylomantis fallax)
Function: Fallaxidin-3.1 shows antibacterial activity against the Gram-positive bacteria E.faecalis (MIC=100 uM) and L.lactis (MIC=100 uM). No antibacterial activity against the Gram-positive bacteria B.cereus, L.innocua, M.luteus, S.epidermidis, S.uberis and S.aureus, or the Gram-negative bacteria E.cloacae and E.coli.
Subcellular location: Secreted {ECO:0000269|PubMed:18803332}.
Interaction partners:
Sequence:
MASLKKSLFLVLFLGLVSLSICEKEKRENEGNENEEEEENHEEGSEEKRGLLDLAKHVIGIASKLGKRSEEKRGLLDFAKHVIGIASKLGK