wanglab/gogpt-training-data huggingface dataset:
Protein: MMS19 nucleotide excision repair protein (Q95U54)
Organism: Drosophila melanogaster (Fruit fly)
Function: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (By similarity). In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity). Essential for diploid cell cycles, organ growth and development. Regulates mitosis by binding to Xpd and thereby competing with the Xpd-mediated repression on the Cdk-activating kinase (CAK) complex. Regulates the centrosomal localization of the MT regulator tacc, a downstream target of aurA kinase. Binds to microtubules (MT). Regulates spindle and astral MT growth, MT stability and bundling. In neuroblasts, necessary for timely and coordinated spindle assembly and orientation which is necessary for mitotic progression. In young embryos, the maternal protein is important for progression through mitosis.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000255|RuleBase:RU367072, ECO:0000269|PubMed:29361561}. Nucleus {ECO:0000255|RuleBase:RU367072, ECO:0000269|PubMed:29361561}. Cytoplasm {ECO:0000269|PubMed:29361561}. Midbody {ECO:0000269|PubMed:29361561}. Note=Localizes to the nucleus at the beginning of metaphase. {ECO:0000269|PubMed:29361561}.
Interaction partners:
- MIP18 family protein galla-2
- Probable cytosolic iron-sulfur protein assembly protein Ciao1
- General transcription and DNA repair factor IIH helicase subunit XPD
- MIP18 family protein galla-1
- ADP/ATP translocase
- Probable cytosolic Fe-S cluster assembly factor CG17683
- Regulator of telomere elongation helicase 1 homolog
- DNA polymerase epsilon catalytic subunit 1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- DNA polymerase delta catalytic subunit
Sequence:
MTTPTRATLEKALKSDQKLVNSATQIAKDLTAKAYDISALAEALGFALSSPDMEERVAGTNLLSAVLIALPQDLLQERQLEFLSTFYMDRLRDHHNVMPAIIDGIDALVHMKALPRAQIPQILQSFFEHTTCQSQTRSDRTKLFHIFQYLTENFQDELQAMAGDFVYGLINSIDGERDPRNLDIIFSFMPEFLSTYPLLHLAEEMFEIFACYFPIDFNPSKQDPAAITRDELSKKLTNCLVANNEFAEGTVVLAIEKLESELLVAKLDSIELLHQAAVKFPPSVLEPHFDQIWQALKTETFPGNDNEEILKASLKALSALLERAAHIPDISHSYQSSILGVILPHLSDVNQRLFHPATGIALVCVSGDAPYAADKILNSFLLKLQAADASSEQRIKIYYIVSQVYKLSALRGSLQKLDTTIRESVQDDVIASLRLIEQEEFDAKKEDLELQKAALSVLNESAPLLNEKQRALIYKALVQLVSHPSIDIDFTTLTVSLGALQPVEVQSNFIDVCVRNFEIFSTFVKRKIYTNLLPLMPQIAFTQRILDLVMTQTFNDTTAEPVRLLALEALNKLLLLADQRFIVDVQQESNLLHKLIELGQKTEGLSMQSLEQIAGALSRITQQLPLSEQSAIVSEYLPGLNLSQSADLYITKGLLGYLHKDITLDDHFERLLTDLTQLSLNSDNEQLRVIAHHLLCSMVNKMESNPANLRKVKKITEQLKVAIKKGDVRAVEILAWVGKGLVVAGFDEAADVVGDLSDLLKHPSLSTAAALGFDIIAAEYPELDLPVVKFLYKQKLFHTIMGKMGSKLANYCVHHLKAFVYVLKATPQAVIKLNIEQLGPLLFKSLEEHNEAQSLCIALGICEKFVAQQDTYFQGHLAHLIPSCLELSKYKAQHTMQVRIAALQLLYDVTKYPTFVLLPHKVDVTLALAAALDDPKRLVRNTAVKARNAWYLVGAPSPN
Protein: Paramyosin, long form (P35415)
Organism: Drosophila melanogaster (Fruit fly)
Function: Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.
Subcellular location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Interaction partners:
- Myosin light chain alkali
- Tropomyosin-2
- Myosin heavy chain, muscle
- Troponin T, skeletal muscle
- Myosin regulatory light chain 2
- Troponin I
- Alpha-actinin, sarcomeric
- Trehalose 6-phosphate phosphatase
- Troponin C, isoform 2
- Bent, isoform F
Sequence:
MSSSQAVRSSKYSYRATSTGPGTADVNIEYIQDLSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHRTFVTTSTVPGSQVYIQETTRTITE
Protein: MIF4G domain containing isoform 3 (A0A0S2Z5K9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGEPSREEYKIQSFDAETQQLLKTALKDPGAVDLEKVANVIVDHSLQDCVFSKEAGRMCYAIIQAESKQAGQSVFRRGLLNRLQQEYQAREQLRARSLQGWVCYVTFICNIFDYLRVNNMPMMALVNPVYDCLFRLAQPDSLSKEEEVDCLVLQLHRVGEQLEKMNGQRMDELFVLIRDGFLLPTGLSSLAQLLLLEIIEFRAAGWKTTPAAHKYYYSEVSD
Protein: TAR DNA-binding protein 43 (Q802C7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RNA-binding protein FUS
- Guanine nucleotide exchange C9orf72 homolog
- Ataxin-2
- SUMO-conjugating enzyme UBC9-B
- Superoxide dismutase
- Homeobox protein goosecoid
- Transitional endoplasmic reticulum ATPase
- VAMP-associated protein B and C
- Protein ref
- Senataxin.
Sequence:
MAEMYIRVAEEENEEPMEIPSEDDGTVLLSTVSAQFPGACGLRFRSPVSQCMRGVRLVDGILHAPENGWGNLVYVVNYPKETVLPDNKRKMDEIDASSATKIKRGDQKTSDLIVLGLPWKTSEQDLKDYFGTFGEVIMVQVKRDVKTGNSKGFGFVRFGDWETQSKVMTQRHMIDGRWCDCKLPNSKQGIDEPMRSRKVFVGRCTEDMTADELRQFFMQYGEVTDVFIPKPFRAFAFVTFADDQVAAALCGEDLIIKGVSVHISNAEPKHNNTRQMMERAGRFGNGFGGQGFAGSRSNMGGGGGGSSSSLGNFGNFNLNPAMMAAAQAALQSSWGMMGMLAQQNQSGTSGTSTSGTSSSRDQAQTYSSANSNYGSSSAALGWGTGSNSGAASAGFNSSFGSSMESKSSGWGM
Protein: Protein lin-9 homolog (Q5RHQ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Lin-37 DREAM MuvB core complex component.
- Protein lin-54 homolog
- Protein lin-52 homolog
- V-myb avian myeloblastosis viral oncogene homolog-like 2b.
- Histone-binding protein RBBP4
- Histone-binding protein RBBP7
- Forkhead box M1.
- E2F transcription factor 4
- Testis-expressed metallothionein-like protein.
- V-myb avian myeloblastosis viral oncogene homolog-like 2a.
Sequence:
MAELEQLLDESSSAKALVSLREGSLSNTLNEKNNLPKSQTTRGRSSYVSMETPTRSSKRSRLSCEDEERPIASRSPRRSQRVTTMPQKLTNVATPDKRVSQKIGLRLRNLLKLPKAHKWCIYEWFYSNIDRPLFEGDNDFCLCLKESFPNLKTRKLTRVEWGTIRRLMGKPRRCSSAFFAEERMALKQKRQKMRLLQQRKITDMSLCKDLPDEIPLPLVIGTKVTARLRGVHDGLFTGQIDAVDTSAATYRVTFDRNGLGTHTVPDYEVLSNEPHETMPISAFAQKQRPPRFQNFLTPPRGSYTGSTQSILMDNDPLFSQSPWRSKLTGTDGETLGGFPVKFLVQVTRLSKILMIKKEHIKHLKEMNTEAEKLKSYSMPIGLDLQKRYATTVLDLEQLNKDLNKVLHEVQQFCFELAPDQGMQPADQPSELRRRCEEESQDVLRQNNTLASGEPRVQNTELTQLISRLTALLLQIRCLAEGGDLNSFEFKSLTDSLNDIKSSIDDSNLSCFQDNVEIHVAHIQSGLSQLGNLHAFSANNTNRT
Protein: Protein FAM163B (P0C2L3)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Zinc finger C2HC domain-containing protein 1B
Sequence:
MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKDESEEDEEEPDFAVHSHLPPLHSNRNLVLTNGPALYPTASTSFSQKSPQARALCRSCSHCEPPTFFLQEPPEEEEDVLNGGERVLYKSVSQEDVELPPGGFGGLQALNPNRLSAMREAFARSRSISTDV
Protein: Muscle segmentation homeobox (Protein drop) (Protein msh) (Q03372)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a key role in the specification of proneural and promuscular cluster formation. Required for the specification of dorsal and lateral muscle progenitor cells. Regulates development of peripheral nervous system derived from lateral neuroblasts.
Subcellular location: Nucleus.
Interaction partners:
- Paired box pox-meso protein
Sequence:
MLKLSPASMTVTGLRQTMTSPTVPPSSNTPAGNLIITSSSSNSGSNSGSNMSSGNMTSSNLTNLSPSHPAGLNALASPTSPSALLLAHQQHLLQQHQQHQQQQQQQQQAAALQLAAVHPPAHHLHKTTSRLSNFSVASLLADTRPRTPPNQAADGPQNLTSSAATSPISQASSTPPPPPASAAAQVPANTFHPAAVAHHAHLLQAAHAAAAAHAQHQAMAAQLRQQQQQADARANSPPASTSSTPSSTPLGSALGSQGNVASTPAKNERHSPLGSHTDSELEYDEEMLQDHEADHDEEEDSIVDIEDMNADDSPRSTPDGLDGSGKSLESPHGPPPGSHMQSTILSPAALASGHVPIRPTPFSALAAAAVAWTGMGGGVPWPGTRQMPPFGPPGMFPGAGFGGDANEPPRIKCNLRKHKPNRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAKAKRLQEAEIEKIKMAALGRGAPGAQWAMAGYFHPSLMHLG
Protein: Large ribosomal subunit protein eL42 (60S ribosomal protein L36a) (60S ribosomal protein L44) (P83884)
Organism: Sus scrofa (Pig)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P83881}.
Interaction partners:
- Large ribosomal subunit protein uL10
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS14
- 40S ribosomal protein S30
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein eL36
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS17
Sequence:
MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF
Protein: Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0146 (EC 2.1.1.-) (P9WFJ3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Interaction partners:
- Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0145
- Aldehyde dehydrogenase
- Probable transcriptional regulatory protein
- Putative short-chain type dehydrogenase/reductase Rv0148
Sequence:
MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFASAVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPADLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEERRAEMRARFKKVADVLGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVEGVPMADDPTAFAEFVTAERL
Protein: Exchange protein directly activated by cAMP, isoform D (GH01501p) (Q7K3Z6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSPDHPNPALPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEPTRKL
Protein: Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter B) (UT-B) (Urea transporter, erythrocyte) (Q8VHL0)
Organism: Mus musculus (Mouse)
Function: Mediates the transport of urea driven by a concentration gradient across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Facilitates water transport in erythrocytes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12133842, ECO:0000269|PubMed:15563580}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15563580}; Multi-pass membrane protein {ECO:0000255}. Note=Restricted to the basolateral membrane in various portions of the urothelium. {ECO:0000269|PubMed:15563580}.
Interaction partners:
Sequence:
MEDSPTMVKVDRGENQILSCRGRRCGFKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILVGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSNKGDYFWWLIFPVSAMSMTCPVFSSALSSVLSKWDLPVFTLPFNMALSMYLSATGHYNTFFPSKLFTPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGGIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFEDIYFGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMAHLMAVVHLPACTWSFCLATLLFLLLTTKNPNIYRMPLSKVTYSEENRIFYLQNKKRMVESPL
Protein: Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) (Q80W98)
Organism: Rattus norvegicus (Rat)
Function: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
Interaction partners:
- Guided entry of tail-anchored proteins factor 4
- Large proline-rich protein BAG6
- ATPase Get3
- Ubiquitin-like protein 4A
Sequence:
MSSVKPLVYAVIRFLREQSQMDAYTSDEQESLEVAIQCLETVFKISPEDTHLAVSQPLTEMFTNSVCKNDIRPLSNSVPEDVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLSHYTDAIKDCEKAIAIDSKYSKAYGRMGLALTAMNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLREVSSPTGTGLTFDMASLINNPAFITMAASLMQNPQVQQLMSGMMTNAIGGPAAGVGGLTDLSSLIQAGQQFAQQIQQQNPELIEQLRNHIRSRSFSSSTEEHS
Protein: Hypoxia-inducible factor 1 subunit alpha,-like (A0A0R4IBR4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Hypoxia-inducible factor 1-alpha
- Hypoxia-inducible factor 1-alpha
- Egl-9 family hypoxia-inducible factor 3.
- Catenin beta-1
- Von Hippel-Lindau tumor suppressor.
- Cellular tumor antigen p53
- Cullin 2
- histone acetyltransferase
- Elongin-C
- Elongin-C
Sequence:
MVNSTSKRPSLEQRKVRSRDAARCRRSQETEVFYELAHSLPLPRRIASHLDKAAIMRVTLSYLRMNRLIQSGSTKSQTEKSETPTDGFYQQALAGFILVMTEEGDMVFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILATRPGVSKKKTMEHNFFLRMKSTLTHTGRTVNIKSATWKVLHCTGHMQPFSGDDENSPSAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNLDLTYTQCDGRVTELVGYQPDDLIGRSAFEFFHALDFDHVSRSLHILFSKGQVCTGQYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEQDVVFSLEQTCEKPKPKVERLMVLKEEQEDSDMEESSTAKLFLQMKENPEELLQLAPHSGDAIISLTEGLELSFCCPQSPNSVPECPQDFCTPELRKLLSPIFDGPAKSHPAASPAEELPMEMEGVEKFFALKPEESLTPKGQSEAVDELDLDMLAPYISMDDDFQLTFLPQSEITPPLEMLTSNSRKRCLEDDDDDDIPVLAARWDKKQMSGPIEDQLLLSHTLLDGLSDGSDEFEPPPQKRSQLLTDRDPLLGGVQALCDTAALMRDTFLSRPPDLRRPVGETLPSLT
Protein: Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) (Q96MH2)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Subcellular location: Nucleus {ECO:0000269|PubMed:15994294}.
Interaction partners:
- 7SK snRNA methylphosphate capping enzyme
- La-related protein 7
- Protein HEXIM1
- Cyclin-dependent kinase 9
- Cyclin-T1
- Cyclin-T2
- Fer3-like protein
- Bromodomain-containing protein 4
Sequence:
MMATPNQTACNAESPVALEEAKTSGAPGSPQTPPERHDSGGSLPLTPRMESHSEDEDLAGAVGGLGWNSRSPRTQSPGGCSAEAVLARKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPHGISHPGSSGESEAGDSDGRGRAHGEFQRKDFSETYERFHTESLQGRSKQELVRDYLELEKRLSQAEEETRRLQQLQACTGQQSCRQVEELAAEVQRLRTENQRLRQENQMWNREGCRCDEEPGT
Protein: Structural maintenance of chromosomes protein 5 (Protein EMBRYO DEFECTIVE 2782) (Q9LFS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core component of the SMC5-SMC6 complex that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associates with chromatin. {ECO:0000250}.
Interaction partners:
- E3 SUMO-protein ligase MMS21
- Non-structural maintenance of chromosomes element 4 homolog A
- Non-structural maintenance of chromosomes element 4 homolog B
- Structural maintenance of chromosomes protein 6A
- Structural maintenance of chromosomes protein 6B
- Structural maintenance of chromosomes protein 3
- Non-structural maintenance of chromosomes element 1 homolog
- Sister chromatid cohesion protein SCC2
- Protein CHROMOSOME TRANSMISSION FIDELITY 7
- Sister chromatid cohesion 1 protein 1
Sequence:
MSERRAKRPKISRGEDDFLPGNIIEIELHNFMTFNHLVCKPGSRLNLVIGPNGSGKSSLVCAIALCLGGEPQLLGRATSVGAYVKRGEDSGYVKISLRGNTREENLTIFRKIDTRNKSEWMFNGSTVSKKDIVEIIQKFNIQVNNLTQFLPQDRVCEFAKLTPVQLLEETEKAVGDPQLPVHHRALVEKSRDLKQLERAVAKNGETLNQLKALVDEQEKDVERVRQRELFLTKVDSMKKKLPWLKYDMKKAEYMDAKKRMKEAEKKLDEAAKNLNSMKEPIEKQKKEKAETDSKCKKVKNLMDANGRNRCHLLEKEDEADARVVATYKELEELKKQEEHRQERILKATEDLVAAERELQNLPVYERPVAKLEELSSQVTELHHSINGKKNQKEDNEKLLSQKRYTLRQCVDKLKDMENANNKLLKALANSGADRIFDAYQWVQQNRHEFKREVYGPVLVEVNVPNRENACFLEGHVSFYIWKSFITQDPEDRDLLVKNLKRFDVPVLNYVGNSGNQKAPFHISDQMRSLGIHARLDQIFDAPDAVKEVLNSQFGLEDSYIGSKITDQRAEEVYKLGIKDFWTPDNHYRWSSSRYGGHSSASVDSVYQSRLLLCGVDVGELEKLRSRKEELEDSILFMEETHKSLQTEQRRLEEEAAKLHKEREEIVNVSYLEKKKRRELESRYQQRKTKLESLEQEEDMDASVAKLIDQASRANADRYTYAINLKKLLVEAVAHKWSYAEKHMASIELERKIRESEINIKQYEKTAQQLSLAVEYCKKEVEGKQQRLATAKRDAESVATITPELKKEFMEMPTTVEELEAAIQDNLSQANSILFINENILQEYEHRQSQIYTISTKLETDKRDLSICMKEIDSLKEKWLPTLRQLVGQINETFSHNFQEMAVAGEVSLDERDTDFDQYGIHIKVKFRESGQLQVLSSHHQSGGERSVSTILYLVSLQDLTNCPFRVVDEINQGMDPINERKMFQQLVRAASQPNTPQCFLLTPKLLPELEYSEACSILNIMNGPYIAEPSKVWSLGDSWGSLNRRRTEASQCS
Protein: Dihydroorotate dehydrogenase (quinone) (J3QRQ3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTE
Protein: Sorting nexin-21 (Q3UR97)
Organism: Mus musculus (Mouse)
Function: Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000305|PubMed:25882846}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:25882846}; Peripheral membrane protein {ECO:0000269|PubMed:25882846}; Cytoplasmic side {ECO:0000269|PubMed:25882846}.
Interaction partners:
Sequence:
MASRLLHRLRHALASDGPGEAAAGPEAEQFPESSELEDDDAEGLSSRLSGTLSFTSAEDDPDDEDEDDEAGLDSPPSGDGASGEDAERSPPPDGQRSSQLLARQLQDFWKKSRNTLVPQRLLFEVTSANVVKDPPSKYVLYTLAVMGPGPPDRQPAQISRRYSDFERLHRNLQRQFRGPMSAISFPRKRLRRNFTAETIARRSRAFEQFLGHLQAVPELRQAPDLQDFFVLPELRRAQSLTCTGLYREALALWANAWQLQTQLGTPSGPDRPLLTLAGLAVCHQELEDPGEARACSEKALQLLGDKRPHPFLAPFLEAHVRLSWRLGLDKRQSEAQLQALQEAGLTSTPPPSLKELLIKEVLD
Protein: Protein LBH (hLBH) (Limb bud and heart development protein homolog) (Q53QV2)
Organism: Homo sapiens (Human)
Function: Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:17390236}. Cytoplasm {ECO:0000269|PubMed:17390236}.
Interaction partners:
Sequence:
MSIYFPIHCPDYLRSAKMTEVMMNTQPMEEIGLSPRKDGLSYQIFPDPSDFDRCCKLKDRLPSIVVEPTEGEVESGELRWPPEEFLVQEDEQDNCEETAKENKEQ
Protein: Bromodomain-containing protein 4 (F1R5H6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:18498094}. Chromosome {ECO:0000269|PubMed:18498094}. Note=Associates with acetylated chromatin.
Interaction partners:
- Cyclin-dependent kinase 9
- Histone H4
- Histone H4
- Cyclin T1
- Histone H3.3
- Histone H3
- Si:dkey-108k21.24.
- Histone H3
- Histone H3.2
- Protein cereblon
Sequence:
MGDGLDAVQMSGSSSSQGQPSSQAPSSFNPNPPETSNPTRPKRQTNQLQYLLKVVLKSLWKHQFAWPFHAPVDAVKLNLPDYYKIIKNPMDMGTIKKRLESAFYTSAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKVFLTKISEMPQQEVEISTTAGKGRGRGRRDPDMNMKVGPVLEPLTASPQTRGLSNLTPGPQTRGPPQGPPTLPPQPIVQIQALPPRVPPSLPTIPLHAPQLGPPFSLGPTDCNPPAPIITAVPPPTQTALPPVHIQQSAAPPILQTPISIPNKRKSQKRKADTTTPTANDQLNESSPAESKSGKTLPRRDNTRPSKLPKKEAPDSQHHWTAAPGTPSPKQQEQLRYCSGIVKDMFAKKHAAYAWPFYKPVDVDTLGLHDYHDIIKHPMDLSTIKDKLETRQYREAQEFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEMLAPAPAPVLHPAPVKTQPVMATASSSDTSSDSSSESESSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQASKPKKKEKEKKEKKKDKHKKKAGVMPALEEILEPPPALKPQGKPKNKDPLPKKSKKLSKKEGGKSNRSMAPPGAAPPTLQPVPGLDTEEDLGLTGGAAMAGMAAGEKCKPMSYEEKRQLSLDINKLPGDKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVSSCLRKKKKPAVPEKSMEAISAVKTKGTSSDSGSSSESSSSESEDSETGMASKPKKRGRGEGKKAHHQTTAPGMPLPQVPLQPQTPALQPSIQLKQQQPQHPSPAAYMPPPVTALEPSQLLENPFDPLAHFMHLPHHANDSSSPAPPHLNAHPPGGPVSPETHPFLNQHPILPSPALHNALPQQPSRPSNRAAPLPPKPLQQSTSQQQPPPQQTLVPPQQLQPQQQQPAPPQQQHLPHHPLHAPQQMRPRPLSPPTLTPQGLLSSQPPQMLLEDDEEPVPSMSLPMYLQHLQPNRLQATPTSLMQSLQSRPQPPGQPSLLQSVQVQSHLPPPQLPVQTQVQPQQPAPHQPSPQLSQHQARHMQQLGFPQGPLQTAQTQPGQHKVSMPSTKAQQIIQQQQATQHHSPRQHKADSYNSAHLRDNPSPLMMHSPQIPQYSLVHQSPSQDKKEPQRGPSALGGIKEEKLPPSPVMRGEPFSPAMRPESHKHPDSKPTMPGHSQQRADMKPLEMSRPVIRSSEQSGPPPSMQDKEKFKQEPKTPSAPKKVQDVKFKNMGSWASLAQKSSTTPSSGLKSSSDSFEQFRRAAREKEEREKALKAQVEQAEKDRLRKEQEKLRGRDEEDSIEPPRRPLEEPRRRQEPQQVQPPPQQHQTQAQAQTLNPAQSPSASQPTQAPPQSPASSQSALDQQREMARRREQERRRREAMAATIDMNFQSDLMAIFEENLF
Protein: AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Q10567)
Organism: Homo sapiens (Human)
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular location: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Interaction partners:
- AP-1 complex subunit sigma-1A
- AP-1 complex subunit mu-1
- AP-1 complex subunit gamma-1
- AP-1 complex subunit sigma-2
- AP-1 complex subunit sigma-3
- AP-1 complex subunit gamma-like 2
- AP-1 complex subunit mu-2
- ADP-ribosylation factor 1
- AP-2 complex subunit mu
- AP-2 complex subunit sigma
Sequence:
MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLMGDEPEGIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9LW66)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative U-box domain-containing protein 53
- U-box domain-containing protein 51
- U-box domain-containing protein 34
- U-box domain-containing protein 35
- Probable E3 ubiquitin-protein ligase ARI3
Sequence:
MDTARAWLKKLKSKGKEKSSNKKETSRGNVKEGSKTAGGEEAVSNVTKQKAAAAKQYIENHYKKQVQSQQQRKERRDMLENKLAAAEVSEEEQKNLLKDLEKKETEYMRRQRHKMGTDDFEPLTMIGKGAFGEVRICREKTTGNVYAMKKLKKSEMLRRGQVEHVKAERNLLAEVDSNCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDTLTEDEARFYVGETVLAIESIHKHNYIHRDIKPDNLLLDRSGHMKLSDFGLCKPLDCSILQEKDFVVAHNLSGALQSDGRPVAPRRTRSQMEQLQNWQRNRRMLAYSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLVGFPPFYSDEPMTTCRKIVNWKNYLKFPDEVRLSPEAKDLICRLLCNVEQRIGTKGANEIKEHPWFSGVEWEKLYQMKAAFIPQVNDELDTQNFEKFEETDKQVPKTPKSGPWRKMLSSKDINFVGYTYKNVEIVNHDQLPGIAELKKKSTKPKRPSIKSLFEDESASSTTSHQGSFMKLLPTQIEVPEKEDKSSSSSETLSSSTTRFDNATS