wanglab/gogpt-training-data huggingface dataset:
Protein: Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78) (Q71SY5)
Organism: Homo sapiens (Human)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:14657022}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 14
Sequence:
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Protein: F17L21.9 (Transmembrane protein) (Q9FZK5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MESSEDVENLSRAIEKLLHEKRKREASGDAFIEDADDQLFLSSLISQLESPNPKGKEDVITGEEEEKEEESADSSPSKGKSEGQRQLEESIEEIAKDIKKVKKQNKITHVLLSATIILTLVWQLSEYSMIFMLKDRISHPVRSIGGMLNGMFKGKLRPIKNQLAGTSNSNDQNNHGNGSHTGPQLQVPELLREFGFDDEE
Protein: Large ribosomal subunit protein eL29 (60S ribosomal protein L29) (Q95281)
Organism: Sus scrofa (Pig)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P47914}.
Interaction partners:
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein uL18
- Uncharacterized protein.
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein uL29
- Ribosomal protein L24.
- Large ribosomal subunit protein eL38
Sequence:
MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAIKALVKPKEVKPNIPKGGSRKLSRLAYIAHPKLGKRARARIAKGLRFCRPKSQAKAQSKAKATAGGTAAAPVPPASAPKGAQAPTKAPQ
Protein: Zinc transporter ZIP12 (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (D4A8R5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Zinc transporter ZIP11
Sequence:
MCFWTELSVWVVLVSHSFSLASSTETSKALTQDNSRVGSHSLLEVLRVLSAGDDRSLNHPQSLIKILLERTGCPQRTDGTQEDCKLCLEPDALSLTAGGDLEDELREEVVQRVSLLLLYYIIHQEEICSSKLNMSNREYEFYLHSLLSLRQDEDSYFLSEKETDDILASTRKYFGTSTSPCMETKILQRESGIQSSNGADEKMLPQLAATIIALSLQGVCLGRKDSPSPDDFTEYIFSFLNRTNALHLSELEELLNMLSTRRACTKINTLHEHQRKQNTAVHGLRDPKSAAAMDKVSGDHSVSWDQACFSAQQLVEIFLQNHSSLSISKEDFKQLSPGIIQQLLSCSCQVPRDQKAKPPPTTLEKYGYSTVAVTLLTLGSMLGTALVLFHSCEENYSLILQLFVGLAVGTLSGDALLHLIPQVLGLHKQEAELGHFHESQSPIWKLLGLLGGIHGFFLIEKCFILLVSPNTKGLPLVNGHAGHTHHLGLSPELNDQSGGGKSISTIQLKGPEDSQTAELPKGNVPASNRNRKTISLLAVMVLVGDGLHNFADGLVIGTAFSSSLESGVTTTIAILCHEIPHEMGDFAVLLSSGLSIRTAILMNFLSALTAFIGLYIGLSVSADPRVQDWILTVTAGMFLYLSLVGMLPEMTHVQTQRPWMTFLLQNVGLVLGWFSLLLLAVYEQNIKI
Protein: D-glycero-alpha-D-manno-heptose 7-phosphate kinase (EC 2.7.1.168) (D-alpha-D-heptose 7-phosphate kinase) (Q0P8I9)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Function: Catalyzes the phosphorylation of D-glycero-alpha-D-manno-heptose 7-phosphate at the C-1 position to form D-glycero-alpha-D-manno-heptose 1,7-bisphosphate.
Interaction partners:
- D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
- Phosphoheptose isomerase 2
- GDP-D-glycero-alpha-D-manno-heptose dehydrogenase
- Methyltransferase family protein
- dTDP-4-dehydrorhamnose 3,5-epimerase
- D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase
- Phosphoheptose isomerase 1
- UDP-glucose 6-dehydrogenase
- Methyltransferase FkbM domain-containing protein
- 4Fe-4S cluster-binding domain-containing protein
Sequence:
MKTIRTQTPLRLGLAGGGTDINLYCDKYTGYVLNATISLYIHCTLIKREDGKIIFDSPDTNSYCEYESKEFLGNDGKLDIFKSIYNRIVKDFTKKPLSFSLHTYSDVPSGSGLGGSSTLVVGVIKAFAEWLNLPLGEYEIAKLAYEIEREDLGIVGGAQDQYAATFGGFNFMEFYNNKRVIVNPLRIKNWIASELEARTVLYFTNITREAKDIEEHKKGKLGDEKSLEAMHAIKQDAIKMKEALFRADFGTLAQILGKSWRSKKIISEIVSNDELERIYKLAIDNGAYSGKTSGAGAGGFMFFFVDPTKKYNLIKALRKEQGYVQDFSFTKEGVKSWRI
Protein: Anon1A3 (Q9TVG2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
GVENLPSVAEAKQNHVDEVKPISEEPGNSSEEVPKAEEPLKSSGETSENGAATETAAAPKEPASVMDVDEDETLVENTPSANKEKALDDEKEPEQKSEEHAAAVLESKEQNEPAKEPTPEPMEVDGSSKGSSDTAQVDTPAIENISAAPETEAAAKTTESSNDVVEVATEGKETVLEVPAAEPKEAESTVESAEELTETSTVVVTEPKEAASSEEEPSKVVDSAEPKEAESNTDESATPVPIDVSTAPASNDVSKPLEIDTTLVKTADSPAKEPQEICEVKKAEINVNGEPKIVNSSAEVGENAAPKVCN
Protein: Carbonic anhydrase 2, isoform B (EC 4.2.1.-, EC 4.2.1.1) (M9PF87)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTNNGHTVLVKMSYNEDEIPSVRGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELHVVLRNLEYPDFASALDKDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKSVNMTNPLPLGEYISKSVESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAFRLLTANDDHLKNNFRPIQPLNDRTLYKNYIEIPIHNMGSIPLVDAENAAGKWRAQAAAVLLPLVVLAALSRTSIFRGF
Protein: Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) (O89000)
Organism: Rattus norvegicus (Rat)
Function: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q12882}.
Interaction partners:
- Uridine monophosphate synthetase, isoform CRA_a.
- Cytochrome b5 reductase 4
- Dihydropyrimidinase
- Beta-ureidopropionase
- NADH-cytochrome b5 reductase 3
- NADH-cytochrome b5 reductase 2
- NADH-cytochrome b5 reductase-like
- NADH-cytochrome b5 reductase 1
- Oxidoreductase NAD-binding domain-containing protein 1
- Thymidine phosphorylase
Sequence:
MAGVLSRDAPDIESILALNPRIQAHATLRSTMAKKLDKKHWKRNTDKNCFICEKLENNFDDIKHTTLGERGALREAVRCLKCADAPCQKSCPTSLDIKSFITSIANKNYYGAAKLIFSDNPLGLTCGMVCPTSDLCVGGCNLHATEEGPINIGGLQQFATEVFKAMNIPQIRSPLLPPPEHMPEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSISTDEMTLSTLKENGYKAAFIGIGLPEPKKDHIFQGLTQVQGFYTSKDFLPLVAKGSKPGMCACHSPLPSVRGAVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFANIRAVPEEMELAKEEKCEFLPFLSPRKVIVKDGKIVGMQFVRTEQDETGNWVEDEEQIVRLKADVVISPFGSVLDDPKVIEALSPIKFNRWGLPEVNPETMQTSEPWVFAGGDVVGMANTTVESVNDGKQASWYIHEYIQAQYGALVPSQPTLPLFYTPVDLVDISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPLYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKNDWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQSVRVPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGSPWPSVGSGKRTTYGGVSGTTIRPIALRAVTAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELSDWDGQSPPTMSHQKGKPVPHIAELMGQKLPSFGPYLERRKKILAASKIRENDQNRACSPLQRKHFNSQKPIPAIKDVIGKSLQYLGTFGELNIMEQVVALIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTVSDTCTGCTLCLSVCPIMDCIRMVSRATPYEPKRGLPLAVKPVC
Protein: Orf6/7 (E4 ORF6/7) (E4 control protein orf6/7) (E1ARS7)
Organism: Human mastadenovirus C
Interaction partners:
Sequence:
MTTSGVPFGMTLRPTRSRLSRRTPYSRDRLPPFETETRATILEDHPLLPECNTLTMHNAWTSPSPPVEQPQVGQQPVAQQLDSDMNLSELPGEFINITDERLARQETVWNITPKNMSVTHDMMLFKASRGERTVYSVCWEGGGRLNTRVL
Protein: Septin 9 (K7ER14)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MGSFRTSKMPKPAEAPTAPSPAQTLENSEPAPVSQLQSRLEPKPQPPVAEATPRSQEATEAAPSCVGDMADTPRDAGLKQAPASRNEKAPVDFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEI
Protein: Tetraspanin-3 (Q9M1E7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the regulation of cell differentiation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15060130}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Tetraspanin-16
- AT3g15480/MJK13_14
- non-specific serine/threonine protein kinase
- Reticulon-like protein B6
- Plasmodesmata-located protein 1
- Probable receptor-like protein kinase At5g59700
Sequence:
MRTSNHLIGLVNFLTFLLSIPILGGGIWLSSRANSTDCLRFLQWPLIVIGISIMVVSLAGFAGACYRNKFLMWLYLVVMLLIIAALIGFIIFAYAVTDKGSGRTVLNRGYLDYYLEDYSGWLKDRVSDDSYWGKISSCLRDSGACRKIGRNFNGVPETADMFFLRRLSPVESGCCKPPTDCGFSYVNETGWDTRGGMIGPNQDCMVWSNDQSMLCYQCSSCKAGVLGSLKKSWRKVSVINIVVLIILVIFYVIAYAAYRNVKRIDNDEPAGEARMTKSHPSHFHL
Protein: fructose-bisphosphatase (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase) (Q38EA4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Transketolase
- Transaldolase
- Fructose-bisphosphate aldolase
- ATP-dependent 6-phosphofructokinase
- Glucose-6-phosphate isomerase
- Phosphotransferase
- Phosphotransferase
- mannose-6-phosphate isomerase
- Ribulose-phosphate 3-epimerase
- Phosphomannomutase
Sequence:
MPDYSRVPSTLMQFLMHNQPKGSRGAFTLLMMAIQTSVKVIEMNIRSAGAQGLFGHLNDGRANATGDEQAKLDVVANNAFKAYLMSSASVSFMGSEEDESIVVVSSGQQGDYVVFFDPLDGSSNIDANISIGSVWGIWCLPKGTKVRTTKDALKVLPRLSGRYLVSSGYAMYGTATNLVITTGSGVNGFTLDTTVGEFIHTHPNITLPQSRPIYSVNEGNLRHWDAWFKQYLHHIKNEGEKAYTARYIGSMVADIHRTLLYGGIFCYPGDKKKPGGKLRLMYEAAPMAFLIEQAGGLALTGDGRLLDVVPKEIHQRAPVFMGSRREVELCMSFKQKYNDRGGVQRERSKL
Protein: BZIP domain-containing protein (Q8ITW3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MQQNIQYTYSSDPRSGGNQNQQLHGISQFQQNSYQPTTYSNSNANNFHSSNSATFIPNSVTQTPQRRMGEEKSLVNMLDAYFIDSTTPSTSTSWNNQQPVQMSSIQQSVGSYNQQIPQLKVGDVDLQVEGMNVKLSSSPDKGEKDRVKKARQAEAARMRYHRLSNEEKRELNLKRTLAQKRKRQREKEMEELESILRETNDIQEDPDITEQLREKRMRAKWAEAARTRYARMTPEERRAHNTRRRMRQMQNAMSAIKKSEFQACGMATGDPQKDDEAVRLHIKTQNAKKAEAARQRYHRMNDDEKRVYNQRRTEAFRRRRMEEEMLLAMPIGRINGEALDRAQQIVVRNAKRAEAARLRYQRMTPDQRKSYNQKRYTPKRRRNEMDDMISAGQMAVGSSGTITMGTGTPAKKDDMDALSSLERDVVKRTQHAQQILLRQRANQSSGTPRSVTPPPQAYIISNGQQQHQQLVGNQGNNGIGQHQVLHQGHMQQQQIQVSHQQSSQSIPQNIYTSGMIIQNQGQQQQGQQQQQGQSQQILNNPYRT
Protein: Alhambra, isoform N (A0A0B4KF76)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMMMDTMDTSQSQPMDVAPAVAVAATSGAALVDFTAAMVSMAATAEAESAESNNNHIDMAEYKEHRKNKKKKREKREREGKEHRHHKHRDREHREHRRHRDRDRDKERDREGHHHHPTHHHPNNSQHSTSASSSPSSASTTPSATIEYVGGSASASPSYLGGGATGTGAAVGATTTYPHNLKIRFLLSGQRTELSPPTHQTSATAEVNAPLASSTSASIAVTASATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSNIKDISSSSNQQASTASSSSAPSLYVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGPPMGGSAGAFHGGTTSAGSSSVIQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTESGNLKISYEKQTTRVQQLQEQEAPPARRSRTLDLSTASASSSSPSAVPATTSPLVVLSNQLPLNSVAASSSTGGLKFTYESQTQMDVPMMPVSAIKDSPPSSPGSEIGSAMHSATTAPGSLTGASTAATAQPGNVRKRGRKAKDATIAAAAAAAAAAAALSNSQQDLKDVRILQNGASNTPGNPAGSTPTPPATPASSNAVSSASSIITHTAAHMLGNQINPNSSVAQKLSEQLHMEVQDHSIYTPDSMNSQYAGVPFPGKQRNSTAVPSNATPAQNPLQSMFSGGGMNGNMPIPQSLEQLLERQWEQGSQFLMEQAQHFDIASLLNCLHQLQSENLRLEEHVTSLIARRDHLLAVNARLQIPLSTIASNTKAEAHASSGNSSTSTIGLGSSTSALNAATTIAAAVSLATTAINTTIPTMANSRPTVAAASSSGVLDYRGPGATSNSSNSNSSNNTISNSVSNSSSNPTSSSSASVPPASSMSISGMSISNATNLGMRHVSAAHGSNNAGNSNSSVWSLTASSTVNSNSLHHQHSSQQQQQHQAQHQSHPLQQQQQQQQQVQHHLHQSHHTSAAVAAAHMLGVGMSLGAGGGAAGGIGRVPTKARR
Protein: DEAD-box ATP-dependent RNA helicase 40 (EC 3.6.4.13) (Q9SQV1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA mismatch repair protein MutS, type 2
- Pescadillo homolog
- Pumilio homolog 6, chloroplastic
- F18C1.18 protein
- Hypoxia-responsive family protein
- Protein phosphatase inhibitor 2
- TOM1-like protein 1
- Probable boron transporter 3
- F-box/LRR-repeat protein 15
- Probable rRNA-processing protein EBP2 homolog
Sequence:
MATTEDTPASAGPRYAPEDPTLPQPWKGLIDGSTGILYYWNPETNVTQYERPSAPPPHSATTPKLAQIPVPSSGQGHQAQHEQAKPVGHVSQQHGFQQQPQQFPSQHVRPQMMQQHPAQQMPQQSGQQFPQQQSQSMVPHPHGHPSVQTYQPTTQQQQQGMQNQHSQMPQQLSHQYAHSQQHYMGFRPHMQTQGLQNSHQTPQGGPHGQQFPSQQEYNSLAPKREGDEFHGGKKTGFSQPHLPNSERSPSQNTHFEANAASQKTNANLAMAQKCNGPQANAAVTQFQQPGANLIHQQLGPRAPNQMDQTMLHQKSHVSPFQSNNTYENNLQSRPGNDSYVNMRMEVPVRGAQPLHPAAMPKDIRISGGPPTNADPAMGQTGHGTYGHAGPAFPNKSLVRPHFVTSPDVPHLSPVEIYRKQHEVTTTGENIPAPYITFESSGLPPEILRELLSAGFPSPTPIQAQTWPIALQSRDIVAIAKTGSGKTLGYLIPAFILLRHCRNDSRNGPTVLILAPTRELATQIQDEALRFGRSSRISCTCLYGGAPKGPQLKELERGADIVVATPGRLNDILEMKMIDFQQVSLLVLDEADRMLDMGFEPQIRKIVNEIPPRRQTLMYTATWPKEVRKIASDLLVNPVQVNIGRVDELAANKAITQYVEVVPQMEKERRLEQILRSQERGSKVIIFCSTKRLCDHLARSVGRHFGAVVIHGDKTQGERDWVLNQFRSGKSCVLIATDVAARGLDIKDIRVVINYDFPTGVEDYVHRIGRTGRAGATGVAFTFFTEQDWKYAPDLIKVLEGANQQVPPQVRDIAMRGGGGGGPGYSQDRRGMVNRFDSGGGGTRWDSGGGFGGRGGGFSGREGGFGGREGGFGGREGGFGGRGGRFGMRDDSFGRGGNRGRGFTGPDAGHMNVGGRGGFGRFGNNNNMESRGFGRGSGRGFGRGVGRFDNRRGRSRSRSPDLVRPRRRSSSYSRSRSRSGSYSRSRSRSRSWSRSRSRSPRHSRDRGGHNRSRSYSRSPSPVYERRDRAPRVSGFDIKPPVESVVNLDMNAAAAIENVVPTSLSERQGNGVVESEVEAALVRPVVDEEP
Protein: Zinc finger protein 34 (Zinc finger protein KOX32) (Q8IZ26)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MLLLLSDQLLLTALRKPNPQAMAALFLSAPPQAEVTFEDVAVYLSREEWGRLGPAQRGLYRDVMLETYGNLVSLGVGPAGPKPGVISQLERGDEPWVLDVQGTSGKEHLRVNSPALGTRTEYKELTSQETFGEEDPQGSEPVEACDHISKSEGSLEKLVEQRGPRAVTLTNGESSRESGGNLRLLSRPVPDQRPHKCDICEQSFEQRSYLNNHKRVHRSKKTNTVRNSGEIFSANLVVKEDQKIPTGKKLHYCSYCGKTFRYSANLVKHQRLHTEEKPYKCDECGKAFSQSCEFINHRRMHSGEIPYRCDECGKTFTRRPNLMKHQRIHTGEKPYKCGECGKHFSAYSSLIYHQRIHTGEKPYKCNDCGKAFSDGSILIRHRRTHTGEKPFECKECGKGFTQSSNLIQHQRIHTGEKPYKCNECEKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQSTHLIQHQRIHTGEKPYKCSECGKAFHNSSRLIHHQRLHHGEKPYRCSDCKKAFSQSTYLIQHRRIHTGEKPYKCSECGKAFRHSSNMCQHQRIHLREDFSM
Protein: E3 ubiquitin-protein ligase DCST1 (EC 2.3.2.27) (DC-STAMP domain-containing protein 1) (RING-type E3 ubiquitin transferase) (Q059Y8)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5T197}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T197}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305|PubMed:35393517}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm. {ECO:0000305|PubMed:35393517}.
Interaction partners:
- Sperm-egg fusion protein TMEM95
Sequence:
MAFLSSTLHSLGIFEKISRIKEVLKNRLLDLTKRRDQAREQQRKRPHTIIQGLLLWSLPVSWIRFLWRQPGEFPVTAFLLGAGTGGLLAIGLFQLLVNPMNIYEEQKVVALYCLASLGAIGWGTSPHIRCASLLLVPKMLGKEGRLFVMGYALAAIYSGPAANLRSNINEVIASLGCTVELQINNTRSAWRVSTAPLRAVFKGMVGSKDSLNKEIQNVSTSFEEMDEQVKSDAGYSSEDWDKNRESTEMFGTSRVRPYLSTQMVYELRTRLRCIHVVNKAILSCYRWFDKKHKNCMRRIHLPLFNNMICVPMKFKFLCNIAKVIEIWCYKRIPVEGNFGQTYDSVNQSIHGLSGEFSANINLKEEKQSSMVGLNTTNWEHMGTEVRDYVRQQETYLQWAMGLLHVLLSCTFLLVFHSAFSYMDHYNWDIRFDNIYISTYFCQIDARRKKLGKQSLLPLRKAERKTVIFPFKATIQAWEMRYVIRELLETLPIVLLLLVLCAIDWALYSVFDTIRQHSFVQYSFRSSHKLEIKVEGDSILAKLLRKTIGALNTSSSTDVETNNMPCLPQPISLNARDYFKASLPTLLLVCLCLAQAFGYRLRRVIAAFYFPKREKKRALFFYNEFLKKRSAFTKLRRAAIVRRANQQKAPPHYLVEALYRRCPLLHRFMRQRCVVCQAMETPDSYVCPTPDCKALYCRSCWDDMQRLCPVCTPREELSSSAHSDSNDDAVYGD
Protein: DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1) (Q38DQ1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Periodic tryptophan protein 2, putative
- Sas10 C-terminal domain-containing protein
- Uncharacterized protein
- Small-subunit processome Utp21 domain-containing protein
- Nucleolar protein 56
- U3 small nucleolar RNA-associated protein 14
- U3 snoRNA-associated protein UTP11, putative
- Nucleolar RNA binding protein, putative
- U3 small nucleolar ribonucleoprotein protein MPP10, putative
- rRNA biogenesis protein, putative
Sequence:
MVKVNVISRSDLEWTKDRNGEVPRVNRNFDSKYNPMAKQVEFTRAIRAAKLDRMFAKPFFGALSGHQDTIQSIAVDFTNLSTVVSGSVDGGMIVWDAFTKRPKVIVDAHRHSIDGLVISPDGVACFSASRDKVVKMWDLDFSSDSSKVEPLAEYLGEFPFSSIDHHYQKSQFVTSSDVVHVWDVNRTQPLQRFSWGDDTVSCCRINKVETNLVACCMSDRGVFIYDTRTQAAHSKVVLEMCCTSLAWNPMDPNTFVTGSDDRNCYLFDMRIPGRPKNVFQGHIAGVTSVDFCPTGKKFAAGSLDFTLRIWDIHQTTKSNSIEMFHTKRMAKVFSVKWSPDSRYLYSGSEDAILRIWKADASKPIRPLRGPEKNTFNYMRSLKDKYSGFVEVRRITNQRNTPKAIRSAQRRSKKAEKREMVKEASRRKSDDIKPLAKRKVYQYLK
Protein: Dumbfounded (KIRRE) (Q9N9Y9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MKRMRSSRLLVLPLILVLILTLLLQPIAVHAKSKKNKSSQSSHHGDSSSSSSSSSSSSSSSGSSSAAASSANDESKPKGGDNGGQHFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLKVSSETAGRYFCKAVVNGFPEIGAEATLYVKRAPIITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVLNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLAINLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKNQQETAYKGSPQANGYAHYFEYALDYSPPGGEGAAVVVGSGGVGKLKNGGMNSATLPHSAAATVNGGGAGNGGGASLPRNQRHEIQQSQQSNGFLGQPLLQNGIDSRFSAIYGNPYLRTNSSLLPPLPPPSTANPAATPAPPPYHAARHGHAHHANGGLKHFVGGAVITTSPVGNVNINGGGGGGSTPSGGGGVGVGVAAGGSVSGSSSNLTASSNTLAATPLAGGGVGNSGQCAQSPSGQFILSNNGKGHTQKGPLATHV
Protein: Sp3 transcription factor (A0A494C070)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPAAYTCFNSSNHSKRLDIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME
Protein: Pfmc-2TM Maurer's cleft two transmembrane protein (B9ZSJ3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MFHYIYKIYIFTIILCASNLFNNNVVEIGTYKLSYHNGGIQFRMLAQKNTNKKPFGNTLTNILFKDKKKKNLDPQISSLVSLVDNMNITQEKKDKIKNLSLKYINSRDVKEKNESINELQKYSNNEECKEYMDSYLMHLRMQNDIKCLKRKNLWNNIWIVSTTLLLIIIMIVCLFSVDITSSSALGPAFILLIFIIHIVARYFPDMKIGFKKLKTKLNTFFQNKKQITK
Protein: ORF 37 (P88925)
Organism: Human herpesvirus 8 type M
Interaction partners:
Sequence:
MEATPTPADLFSEDYLVDTLDGLTVDDQQAVLASLSFSKFLKHAKVRDWCAQAKIQPSMPALRMAYNYFLFSKVGEFIGSEDVCNFFVDRVFGGVRLLDVASVYAACSQMNAHQRHHICCLVERATSSQSLNPVWDALRDGIISSSKFHWAVKQQNTSKKIFSPWPITNNHFVAGPLAFGLRCEEVVKTLLATLLHPDETNCLDYGFMQSPQNGIFGVSLDFAANVKTDTEGRLQFDPNCKVYEIKCRFKYTFAKMECDPIYAAYQRLYEAPGKLALKDFFYSISKPAVEYVGLGKLPSESDYLVAYDQEWEACPRKKRKLTPLHNLIRECILHNSTTESDVYVLTDPQDTRGQISIKARFKANLFVNVRHSYFYQVLLQSSIVEEYIGLDSGIPRLGSPKYYIATGFFRKRGYQDPVNCTIGGDALDPHVEIPTLLIVTPVYFPRGAKHRLLHQAANFWSRSAKDTFPYIKWDFSYLSANVPHSP
Protein: BRO1 domain-containing protein (Q4GYP6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSAFALATRGEPVSWEKLVVRALSFIDATPSVAATNALHALTSYSASPPSIYCDAAAGVRNAKLHSGLLLSLHHATAQWPKLLRHMLAPPPVIVGEQSLSISGPAMELFVVLYNASVSNCEAGFAAMSRAHADAARTGMMTAAETPSSSPLANSKSAFKSFTMGAELAFLAEQALAEGGDELLPAVDRHSLQKQLDFRSIHELAELCVATAKYVYSTTSGAVSKKHDTLAKLAYAAATTAVPLGLKAMSLLLTVMSRLLTAAYHRHMAEHYYRLDKVPDMSLVLGHIMYAMKLLKKIQVDCPAVLRGHATSQKAPPSSSSDAMRSVRQLLGQISASIVGNGGTGAKEQGCQSINELADLLEEGDMMKVFPLAGSLVRDVAKLHEKYQHENSVVYYSRPASDEEIKDDVPEAKLLDVASDSIRYSSNREELLEVLAKRLDTDLSKFAELPAPDELASSLEGREMMVRVRDKLKALQQLTADAKETLSIPHFVEPTLTQLESLLQPYVKPAIQDRGASRNDEGSGATTDSPCPLDSCLDAAVNNVEEALSRHLQVSNGLYRAKCEYIGEYVGPFEVTETLKNRQHAWLTRVHQLRSSVRSILIHRDKKVELRETLLLPESTVLQPCLANAVTVVERAGDLLSSLEPKRASRGTTPPASDNSSDEQLSAAARLQVLLETLCEADGSLTAAFERAQPLRDETRWARVAGVLREAAELIGEGNNIVSEAVSATDEMEKQQSRIVVHPIERLQDVVFETPSLPGQRKRRGKQAEPPRQRMATPTKQELEGASCSTSEQAPCRKGKNRHTGLGEKAEVVEGVRWSWPSTVEKGIRTENTSGAESPADNVAVVGSVRSTKRSREGTPLSPLNSSVASDAAGQLNIPEAEASPLFKRRIKELNSGRIGRKGGEAGGRKGN
Protein: Asnovolin E/Chermesin D methyltransferase nvfJ (EC 2.1.1.-) (Novofumigatonin biosynthesis cluster protein J) (A0A2I1BSV7)
Organism: Aspergillus novofumigatus (strain IBT 16806)
Function: Methyltransferase; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase nvfA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations. DMOA is then converted to farnesyl-DMOA by the farnesyltransferase nvfB. Epoxydation by FAD-dependent monooxygenase nvfK, followed by a protonation-initiated cyclization catalyzed by the terpene cyclase nvfL leads to the production of asnavolin H. The short chain dehydrogenase nvfC then as a 3-OH dehydrogenase of asnovolin H to yield chemesin D. There are two branches to synthesize asnovolin A from chemesin D. In one branch, chemesin D undergoes Baeyer-Villiger oxidation by nvfH, methylation by nvfJ, and enoyl reduction by the nvfM D enoylreductase that reduces the double bond between C-5'and C-6', to form respectively asnovolin I, asnovolin K, and asnovolin A. In the other branch, the methylation precedes the Baeyer-Villiger oxidation and the enoyl reduction to yield asnovolin A via the asnovolin J intermediate. Asnovolin A is further converted to fumigatonoid A by the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfI that catalyzes an endoperoxidation reaction. The alpha/beta hydrolase nvfD then acts as an epimerase that converts fumigatonoid A to its C-5' epimer, which then undergoes spontaneous or nvfD-catalyzed lactonization. The following step utilizes the ketoreductase nvfG to produce fumigatonoid B. The dioxygenase nvfE further converts fumigatonoid B into fumigatonoid C. Finally the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfF catalyzes two rounds of oxidation to transform fumigatonoid C into the end product, novofumigatonin A.
Interaction partners:
- Extracellular protein
Sequence:
MTVETITPQTPVSLPKTAVICNDFKLDRVNEPARSILEKYSKIPSREILEHVRKIRDEAFAEFPYPCIGRFSFLDLSISQSPKYPEILHRVVNGEKFLDLGCAFGQELRQLVYDGAPSDNLYGSDLHNGLMHLGYDLFRDVSTLKSRFIATNILEGNSDLISQLSGQMNIIYSSLFFHLFDWDQSLVIAKHVLRLLSLQPGSMITGRFVAYRDWNFAKEKLGSTLRFYFDLSSWTQLWKQVEVDTGSKLNIEHWEQSDNMLTDNGIGGYMLCFAITRQ