wanglab/gogpt-training-data huggingface dataset:
Protein: Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF) (P18893)
Organism: Mus musculus (Mouse)
Function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P22301}.
Interaction partners:
- Interleukin-10 receptor subunit alpha
- Interleukin-10 receptor subunit beta
- Interleukin-7
- Interferon gamma
- Interleukin-1 beta
- Interleukin-6
- Tumor necrosis factor
- Interleukin-5
- Interleukin-23 receptor
- Interleukin-4
Sequence:
MPGSALLCCLLLLTGMRISRGQYSREDNNCTHFPVGQSHMLLELRTAFSQVKTFFQTKDQLDNILLTDSLMQDFKGYLGCQALSEMIQFYLVEVMPQAEKHGPEIKEHLNSLGEKLKTLRMRLRRCHRFLPCENKSKAVEQVKSDFNKLQDQGVYKAMNEFDIFINCIEAYMMIKMKS
Protein: Csp1p (A0A1D8PSZ6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
- Cell wall mannoprotein PIR1-like C-terminal domain-containing protein
- Rme1p
Sequence:
MKFSTAALTFSLLAIVNSSVITYDTEFGDNYEHKHDKYDCEIDTFNWKFALVVKEWKYHKDEKFCKDTDLDLVYEGEDGQLYHGCDGTYPYSKCKHCTNVFAGGDDNKWKDDKWDDKYKDKKCHDKWDDKCKDKCDDKHKDDHCKDKKCDDKWDNKCHDKCKDDDKCHDKCKDKKCDDKQKHDHCKDDNKCHDKCKDKKCDDKCKDGDDKCHDDCKDDDKCDKHHCKYPYCEIHNTDCDLLITLCNGVLKDKRDATGEIAANHQFQFDKPPQKDALHKEGFSIVHTEGTYYLALNHKIEFWHCKVDDKGLYKIYDKSIGPQCSKIELIVLKSDEKATFSNDDCDDDCKKKQKHD
Protein: B- and T-lymphocyte attenuator (B- and T-lymphocyte-associated protein) (CD antigen CD272) (Q7TSA3)
Organism: Mus musculus (Mouse)
Function: Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12796776}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 14
- Tyrosine-protein phosphatase non-receptor type 11
- V-set domain containing T-cell activation inhibitor 1
- Programmed cell death 1 ligand 1
- CD160 antigen
- Lymphocyte activation gene 3 protein
- Programmed cell death protein 1
- Hepatitis A virus cellular receptor 2 homolog
- Galectin-9
- Growth factor receptor-bound protein 2
Sequence:
MKTVPAMLGTPRLFREFFILHLGLWSILCEKATKRNDEECPVQLTITRNSKQSARTGELFKIQCPVKYCVHRPNVTWCKHNGTICVPLEVSPQLYTSWEENQSVPVFVLHFKPIHLSDNGSYSCSTNFNSQVINSHSVTIHVRERTQNSSEHPLITVSDIPDATNASGPSTMEERPGRTWLLYTLLPLGALLLLLACVCLLCFLKRIQGKEKKPSDLAGRDTNLVDIPASSRTNHQALPSGTGIYDNDPWSSMQDESELTISLQSERNNQGIVYASLNHCVIGRNPRQENNMQEAPTEYASICVRS
Protein: Antitermination protein N (Regulatory protein N) (PN) (P03045)
Organism: Escherichia phage lambda (Bacteriophage lambda)
Function: Plays a role as a transcriptional antitermination factor that allows the virus to initiate its lytic phase. Activates expression of the delayed viral early genes by modifying host RNA polymerase (RNAP) into a form that is resistant to termination signals. This antitermination function requires the host NusA protein which serves to stabilize the interaction between antitermination protein N and host RNA polymerase.
Interaction partners:
Sequence:
MDAQTRRRERRAEKQAQWKAANPLLVGVSAKPVNRPILSLNRKPKSRVESALNPIDLTVLAEYHKQIESNLQRIERKNQRTWYSKPGERGITCSGRQKIKGKSIPLI
Protein: Mitochondrial adapter protein MCP1 (MDM10-complementing protein 1) (Q12106)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Recruits the lipid transfer protein Vps13 to mitochondria thereby promoting vacuole-mitochondria contacts. Involved in mitochondrial lipid homeostasis.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16407407, ECO:0000269|PubMed:23781023}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Intermembrane lipid transfer protein VPS13
- Mitochondrial distribution and morphology protein 10
- Mitochondrial distribution and morphology protein 12
- Endosomal/vacuolar adapter protein YPT35
- Prospore membrane adapter protein SPO71
- Mitochondrial distribution and morphology protein 34
- ABC1 family protein MCP2
- Vacuolar morphogenesis protein 6
- Maintenance of mitochondrial morphology protein 1
Sequence:
MIKLHEVPPEPVDPASLPHDVNAHSPEGDGNPDKRKKIFGIPYPFSRSSCRRFLWNCQKISVLPMALYFPLHAANTLITPAVSPDSAPDDVLMMVREILPSITTKLLVAGITLHVSAGVLLRIVNNWNKPRRNRHRHLKISAEQDLSQDSIGLTGGISGYLFGLYKTFRIPPQVISGYILVPVLIYHLLIMKWVPNSISTEVDFASIKQLLSSKNRWWKWLGGLVPLAILLESGVYHIGSGLCRYFGVRKMTSRKKWSTAINLLTLVGFVSLIRLMKEDSTKLGPNQFESIFKKIRLLLHVN
Protein: OmpA family protein (Q72C62)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004442}.
Interaction partners:
- Tol-Pal system protein TolB
- Desulfoferrodoxin
- WD40 domain protein beta Propeller
- DNA-binding protein HU
- Adenylylsulphate reductase, beta subunit
- Adenylyl-sulphate reductase, alpha subunit
- TPR domain protein
- Pyruvate:ferredoxin oxidoreductase
Sequence:
MPESGETSDLEAYMKFARYLALLAALVFACASSALAASPEKVLVPKISSFDFFVDYSGSMAMKHAKLGKDKIVVAKELMTAINAKIPALGYKGGLHTFAPSSEVIAQGPWDRAGYEKGIKSLKSNFDIFGRLTPMSQGFEKALPYVQNMQRKAAVILISDGEANVGMDPVTAAKAVAALKDVCIHVISLADTAKGQATLDAISKLSPCSVSVNGADLLNNEKALDKFVRDVFYDEQAPKAAAAPMEEVIVLRNVQFALNSAKLDASATSILTEAARIIKANPGKKLLVAGHTCNLGTDAYNLKLSDARAKSVKDFLVKQGVEASRLDTFGFGESQPKYDNGTEQGRSMNRRVELSFR
Protein: Replicative DNA helicase DnaB (EC 5.6.2.3) (DNA 5'-3' helicase DnaB) (O25916)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.
Interaction partners:
- DNA primase
- Chromosomal replication initiator protein DnaA
- Elongation factor Tu
- Bifunctional NAD
- Sensor histidine kinase CrdS
- DNA polymerase III subunit gamma/tau
- Transcriptional regulatory protein CrdR
- DNA polymerase III subunit alpha
- Competence locus E
- Beta sliding clamp
Sequence:
MDHLKHLQQLQNIERIVLSGIVLANHKIEEVHSVLEPSDFYYPPNGLFFEIALKLHEEDCPIDENFIRQKMPKDKQIKEEDLVAIFAASPIDNIEAYVEEIKNASIKRKLFGLANTIREQALESAQKSSDILGAVEREVYALLNGSTIEGFRNIKEVLESAMDLITENQRKGSLEVTGIPTGFVQLDNYTSGFNKGSLVIIGARPSMGKTSLMMNMVLSALNDDRGVAVFSLEMSAEQLALRALSDLTSINMHDLESGRLDDDQWENLAKCFDHLSQKKLFFYDKSYVRIEQIRLQLRKLKSQHKELGIAFIDYLQLMSGSKATKERHEQIAEISRELKTLARELEIPIIALVQLNRSLENRDDKRPILSDIKDSGGIEQDADIVLFLYRGYIYQMRAEDNKIDKLKKEGKIEEAQELYLKVNEERRIHKQNGSIEEAEIIVAKNRNGATGTVYTRFNAPFTRYEDMPIDSHLEEGQETKVDYDIVTT
Protein: Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) (Q62986)
Organism: Rattus norvegicus (Rat)
Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92731}.
Interaction partners:
- Nuclear receptor coactivator
- Estrogen receptor
- Proto-oncogene tyrosine-protein kinase Src
- Nuclear receptor coactivator 3
- Nuclear receptor coactivator 2
- Transcription factor Sp1
- Transcription factor Jun
- Protein c-Fos
- Mediator of RNA polymerase II transcription subunit 1
- Mitogen-activated protein kinase 3
Sequence:
MEIKNSPSSLSSPASYNCSQSILPLEHGPIYIPSSYVDNRHEYSAMTFYSPAVMNYSVPGSTSNLDGGPVRLSTSPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLSGSSCASPVTSPNAKRDAHFCPVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVHCLSKAKRNGGHAPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEAESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ
Protein: 17beta-hydroxysteroid dehydrogenase type 10/short chain L-3-hydroxyacyl-CoA dehydrogenase (Hydroxysteroid (17-beta) dehydrogenase 10) (Q99N15)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAAAVRSVKGLVAVVTGGASGLGLATAKRLVGQGATAVLLDVPDSEGEAQAKKLGESCIFAPANVTSEKEIQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHQKKNKIHTLEDFQRVINVNLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPTGIRVVTIAPGLFATPLLTTLPEKVRNFLASQVPFPSRLGDPAEYAHLVQTIIENPFLNGEVIRLDGAIRMQP
Protein: Tubby-like F-box protein 7 (AtTLP7) (Q93VI8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable ADP-ribosylation factor GTPase-activating protein AGD13
- Probable peroxygenase 5
- Protein PLANT CADMIUM RESISTANCE 11
- Shaggy-related protein kinase beta
- F-box protein At3g62230
Sequence:
MPLSRSLLSRRISNSFRFHQGETTTAPESESIPPPSNMAGSSSWSAMLPELLGEIIRRVEETEDRWPQRRDVVTCACVSKKWREITHDFARSSLNSGKITFPSCLKLPGPRDFSNQCLIKRNKKTSTFYLYLALTPSFTDKGKFLLAARRFRTGAYTEYIISLDADDFSQGSNAYVGKLRSDFLGTNFTVYDSQPPHNGAKPSNGKASRRFASKQISPQVPAGNFEVGHVSYKFNLLKSRGPRRMVSTLRCPSPSPSSSSAGLSSDQKPCDVTKIMKKPNKDGSSLTILKNKAPRWHEHLQCWCLNFHGRVTVASVKNFQLVATVDQSQPSGKGDEETVLLQFGKVGDDTFTMDYRQPLSAFQAFAICLTSFGTKLACE
Protein: Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (P47876)
Organism: Mus musculus (Mouse)
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P08833}.
Interaction partners:
- Insulin-like growth factor 1
- Insulin-like growth factor 2
- Insulin-1
- Insulin-2
- Insulin-like growth factor-binding protein 6
- Secreted phosphoprotein 24
- Insulin-like growth factor 1 receptor
- Cation-independent mannose-6-phosphate receptor
- Pappalysin-1
- Protein delta homolog 1
Sequence:
MPEFLTVVSWPFLILLSFQIGVAAGAPQPWHCAPCTAERLGLCPPVPASCPEISRPAGCGCCPTCALPMGAACGVATARCAQGLSCRALPGEPRPLHALTRGQGACVPEPAAPATSTLFSSQHEEAKAAVVSADELSESPEMTEEQLLDSFHLMAPSREDQPILWNAISTYSSMRAREIADLKKWKEPCQRELYKVLERLAAAQQKAGDEIYKFYLPNCNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRGDPNCHQYFNVHN
Protein: AT3G18790 protein (AT3g18790/MVE11_17) (Pre-mRNA-splicing factor ISY1-like protein) (Q9LS97)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Pre-mRNA-processing-splicing factor 8A
- Tetratricopeptide repeat
- DExH-box ATP-dependent RNA helicase DExH12
- Cell division cycle 5-like protein
- Pre-mRNA-splicing factor SYF2
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Zinc finger CCCH domain-containing protein 4
- ATPase E1
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-processing factor 19 homolog 1
Sequence:
MARNEEKAQSMLNRFITQKESEKKKPKERRPYLASECRDLAEADKWRQQILREIGSKVAEIQNEGLGEHRLRDLNDEINKLLRERYHWERRIVELGGHNYSKHSAKMTDLEGNIIDVPNPSGRGPGYRYFGAAKKLPGVRELFEKPPELRKRKTRYDIYKRIDASYYGYRDDEDGILEKLERKSEGGMRKRSVEEWRRLDEVRKEARKGASEVVSVGAAAAAAREVLFEEEEDVVEEERMEREKEEEKEREFVVHVPLPDEKEIEKMVLEKKKMDLLSKYASEDLVEQQTEAKSMLNIHR
Protein: Immunoglobulin kappa variable 5-2 (Ig kappa chain V region EV15) (P06315)
Organism: Homo sapiens (Human)
Function: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular location: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
Interaction partners:
Sequence:
MGSQVHLLSFLLLWISDTRAETTLTQSPAFMSATPGDKVNISCKASQDIDDDMNWYQQKPGEAAIFIIQEATTLVPGIPPRFSGSGYGTDFTLTINNIESEDAAYYFCLQHDNFP
Protein: Vesicle transport v-SNARE 13 (AtVTI13) (Vesicle soluble NSF attachment protein receptor 13) (Vesicle transport v-SNARE protein VTI13) (Q9LVP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as a v-SNARE responsible for targeting vesicles involved in the secretory pathway (By similarity). Involved in actin-dependent endosomal trafficking pathways associated with the vacuole within root hairs and root tip epidermal cells. Essential for cell wall organization and polarized root hair growth. Also required for the localization of SYP41 to the trans-Golgi network in root hair cells.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:15342965, ECO:0000269|PubMed:24737717}; Single-pass type IV membrane protein {ECO:0000255}. Prevacuolar compartment membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:24737717}; Single-pass type IV membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:24737717}; Single-pass type IV membrane protein {ECO:0000255}. Note=Present in a mobile endosomal compartment as well as in vacuolar 'bulb'-like structures. {ECO:0000269|PubMed:24737717}.
Interaction partners:
- VAMP-like protein YKT62
- VAMP-like protein YKT61
- Syntaxin-52
- Syntaxin-51
- Tlg2p-like protein a
- Syntaxin-42
- Syntaxin-43
- Syntaxin-61
- Syntaxin-31
- Syntaxin-21
Sequence:
MSQGFERYERQYCEISANLSKKCTSAIALDGEQKKQNLSEIKSGVEEAEALVKKMDLEARNLPPNVKSSLLVKLREYKSDLNNFKTEVKRITSGNLNATARDELLEAGMADTLTASADQRSRLMMSTDHLGRTTDRIKDSRRTILETEELGVSILQDLHGQRQSLLRAHETLHGVDDNVGKSKKILTTMTRRMNRNKWTIGAIITVLVLAIIFILYFKLTR
Protein: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein (Cnt-b) (Centaurin-beta) (A2ADA6)
Organism: Mus musculus (Mouse)
Subcellular location: Endosome membrane {ECO:0000256|RuleBase:RU369028}; Peripheral membrane protein {ECO:0000256|RuleBase:RU369028}.
Interaction partners:
Sequence:
MTVEFEECIKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMIEAGKAYVTTNRLFVSGVRDLSQQCQGDTVISECLQRFGDSLQEMVNYHTILFDQAQRSVRQQLHNFVKEDVRKFKETKKQFDKVREDMELSLVRNAQAPRHRPHEVEEATGALTVTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHAQYSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRDFSYDEPKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSTTDSRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSTVNQIYEAQCEGPGVRKPTASSSRQDKEAWIKDKYVEKKFLRKLTSAPAREPPRRWRAQKCQRPHSSPHAPTTRRKVRLEPVLPSVAALSSAATMERKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSDGSSDVLAFGTGSVVDSVTEEEGAESEESSSEVDGEAEAWSLADVRELHPGLLAHQAARTRDLPALAAALAHGAEVNWADAADEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSLGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLARMAEEMREAEAPPGQPGPLPGSSPTELQYRRCIQEFIGLHLEES
Protein: Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) (P67827)
Organism: Bos taurus (Bovine)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45' (By similarity). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P48729}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P48729}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P48729}. Nucleus speckle {ECO:0000250|UniProtKB:P48729}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BK63}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8BK63}. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton. {ECO:0000250|UniProtKB:P48729}.
Interaction partners:
- Glycogen synthase kinase-3 beta
- Axin-1
- Catenin beta-1
- Adenomatous polyposis coli protein
- Polyubiquitin-C
- Low-density lipoprotein receptor-related protein
- Annexin A11
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGF
Protein: Prosap, isoform D (A0A0B4K7Z0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGSGAFDDEPPPEPRDGWLLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKAGKFLDEERRLGDYPFNGPVGYLELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVEKIAKMCAKGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDSLEAVSTLLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQVAVIAGNLELAEIIENYKSEDIVPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGGGFGGAMVGSNGAANGNNGAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQLHGPPSPCPSEHMLGAYSSASSSLSEGSSGHRSHEDDISIVTDKSLGDTSDIISDSSGVGTNSDSAACSIGHPSTTVVCMEPYAGNTVGHIRLQPGDVIEVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLRQKHITNVMTASTGMAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPSLSVASNGSCQQPLESNEGGASGNGINNRNNNHSVGQYSSATAPRIKKSAYNAPRSVVLHRAKRGFGFILRGAKASSQLMQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLTVVSPQFPHQMQASAQYLPSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGGSVRMAPMPPRRDPKTTLSVGRARAKSMVAGLENGGEKEDDLPHTKSNSVESIATPTPTGIQTGPGTPVQLRTASIKARPTSSRITAAELEELFQRQQGEGSAANASRYATMMTSSRFQSGTDSGAATPPASNGSPMRSGPLVYGSVAEMKRKTARSKHGSGTLRGKPVATPTVGPGGAGGGRDLKRFHSTPDLHGPQLHGSASSIWQASGKGHHSQDDVATLHASLQRLNSNQGELKLGGLGAGSATGAGGAVLPPPNHPPPPPPVGQVVKVETRSSVSEYESTISLQQKLKKRTENDAVTSAAIDGVQSSFNPSANAKIYASPQELRNVMAWKLRQAQEKPSQETSAGSQQPVSQYAAPTQMRPAQQQQQAQQPPTALASHYAAPQVQVQQVQQVQQSPQQSAPQSPPAPPLPQAAPVPAQNGNGNGSTSGAGSAPPIPEPDYSCSESDGEDENSILVARNTKLNEKIALFDVPETSGNSQASGSSSNSGSASISHSLSVEEIQRIRSNLKTSKSSPNGFAKKPEEEKPQQEQQQSHQQPQQLLQPGEDECDNSSSGVSSEQEQLALAAGVTLPGGGKPTDTIKKKPSVTIVEEPKTIPDQPSSNTSHTTKPMAKTTISIGGGGSAVPTATLTVKQLVQQQHAPVIQQQQQQLGSKQPVTAASTNKFTQQSNINSNVMSPQVLGRIPSHHHQQQSSNPNQKLIATQQQILQQQQQQLAHQQHLQQILKAKAAAAGGASNTAVLVAKHQQKLHKGTSSGHESEMETRSDLEDDDGDLSPSPPAKAFQRHNSLTRKQAAAIAMQRGATRTTAVSLMQLPPPLEADSDGEPSQLTLQRQQSHHPSQTHPHPHQLQQQLQLQQQQQQQQQQQQPMAAHIVGMLPSGQLVAVASGAVAGVPGVGATAVQQGNNNLQQLCTDNLVLAPPPQFCDCNDAKHAPQPHLPTSQYHPQQQQQQQHQQQQQQQQQLQQQLQQQQMLQMHQRLSGGAGAGAVGTLGRVRIVGAMPKANHHRLH
Protein: Myosin light chain 12A (A0A8I5ZNJ5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDLTATMSSKRAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASMGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEAIGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
Protein: ABC transporter G family member 19 (ABC transporter ABCG.19) (AtABCG19) (White-brown complex homolog protein 19) (AtWBC19) (Q9M3D6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Confers selective resistance to kanamycin.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:16116418}; Multi-pass membrane protein {ECO:0000269|PubMed:16116418}.
Interaction partners:
Sequence:
MNLSLSGRKIAMTRVSAETQYITPIGSPTLDELLKDCDSFRKGDSGDGVKSDDPAHHIIDVEALYVKPVPYVLNFNNLQYDVTLRRRFGFSRQNGVKTLLDDVSGEASDGDILAVLGASGAGKSTLIDALAGRVAEGSLRGSVTLNGEKVLQSRLLKVISAYVMQDDLLFPMLTVKETLMFASEFRLPRSLSKSKKMERVEALIDQLGLRNAANTVIGDEGHRGVSGGERRRVSIGIDIIHDPIVLFLDEPTSGLDSTNAFMVVQVLKRIAQSGSIVIMSIHQPSARIVELLDRLIILSRGKSVFNGSPASLPGFFSDFGRPIPEKENISEFALDLVRELEGSNEGTKALVDFNEKWQQNKISLIQSAPQTNKLDQDRSLSLKEAINASVSRGKLVSGSSRSNPTSMETVSSYANPSLFETFILAKRYMKNWIRMPELVGTRIATVMVTGCLLATVYWKLDHTPRGAQERLTLFAFVVPTMFYCCLDNVPVFIQERYIFLRETTHNAYRTSSYVISHSLVSLPQLLAPSLVFSAITFWTVGLSGGLEGFVFYCLLIYASFWSGSSVVTFISGVVPNIMLCYMVSITYLAYCLLLSGFYVNRDRIPFYWTWFHYISILKYPYEAVLINEFDDPSRCFVRGVQVFDSTLLGGVSDSGKVKLLETLSKSLRTKITESTCLRTGSDLLAQQGITQLSKWDCLWITFASGLFFRILFYFALLFGSRNKRT
Protein: Histidine permease (P06775)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: High-affinity permease for histidine.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Clathrin light chain
- Secretory component protein SHR3
- Clathrin heavy chain
- Protein SCD5
Sequence:
MPRNPLKKEYWADVVDGFKPATSPAFENEKESTTFVTELTSKTDSAFPLSSKDSPGINQTTNDITSSDRFRRNEDTEQEDINNTNLSKDLSVRHLLTLAVGGAIGTGLYVNTGAALSTGGPASLVIDWVIISTCLFTVINSLGELSAAFPVVGGFNVYSMRFIEPSFAFAVNLNYLAQWLVLLPLELVAASITIKYWNDKINSDAWVAIFYATIALANMLDVKSFGETEFVLSMIKILSIIGFTILGIVLSCGGGPHGGYIGGKYWHDPGAFVGHSSGTQFKGLCSVFVTAAFSYSGIEMTAVSAAESKNPRETIPKAAKRTFWLITASYVTILTLIGCLVPSNDPRLLNGSSSVDAASSPLVIAIENGGIKGLPSLMNAIILIAVVSVANSAVYACSRCMVAMAHIGNLPKFLNRVDKRGRPMNAILLTLFFGLLSFVAASDKQAEVFTWLSALSGLSTIFCWMAINLSHIRFRQAMKVQERSLDELPFISQTGVKGSWYGFIVLFLVLIASFWTSLFPLGGSGASAESFFEGYLSFPILIVCYVGHKLYTRNWTLMVKLEDMDLDTGRKQVDLTLRREEMRIERETLAKRSFVTRFLHFWC
Protein: Uncharacterized protein (Q38CF0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRGHHRLRVNVSGEYAGRALNLLLVSGRHVATRKLSNFEEVATLRRELAAAQQRIAELQLSQVAVHEALLKRLEESHQAVHKAAIHARHAALALQCSHDLMERELRRVLSITPTSSNMSGVEVDRLRRAAVEAGAREIVRRNIGFRVEKQLEDQLQVEKDSGESNTIKGG