wanglab/gogpt-training-data huggingface dataset:
Protein: Fibroblast growth factor 10 (FGF-10) (Keratinocyte growth factor 2) (O15520)
Organism: Homo sapiens (Human)
Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Klotho
- Pro-epidermal growth factor
- Fibroblast growth factor-binding protein 1
- Fibroblast growth factor receptor 3
- Decorin
- Vascular endothelial growth factor receptor 2
- Basement membrane-specific heparan sulfate proteoglycan core protein
Sequence:
MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS
Protein: Fumitremorgin C synthase (EC 1.14.19.71) (Cytochrome P450 monooxygenase ftmP450-2) (Fumitremorgin biosynthesis protein E) (Q4WAW8)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities. The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA. Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B. The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively. The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable). FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B. Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties. In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Fumitremorgin C monooxygenase
- 6-hydroxytryprostatin B O-methyltransferase
Sequence:
MERLPLSPAVLFLIIVLPILYLWIRYTAPARPHGKHLSLPPGPPRLPKIGNLHQVPRQIPWKKYKEWSDTYGPIMSVQLADTIAVVFSSWDLIKNHIERRNTIYSSRPSVPFFLHATGGLNASILPYGPEWKLQRAIRSSVLKPSMTVKYRDVQHVETTQLLHELLSTNDFPVCLRRCIASVFLTVAYGERCVDHAGLEAIDRLEELNRAIALHAEALFSGAAGILTQLVLPKALVDRLPVRWKKDADMLHNRLTADLVARTRAALVRPGWNWVKEFSMKDGIGSGDGDGEQGSKVELKRLAYMVGSLYEASMAASQALRVIILAGLLHPDATRRMHDELDAVVGTGRLPDFHDAAQLPYTQAFIKEAMRWRSLTPMGSPRATSDEDECRGYHIPCGATVLVNVWAINHDEAIFLDPFAFQPERWIENPDLPQLMYGMGQRACPGRHMGQDSLFLATARLFWAFDMALPDGADPIDQERFLDSGTTLAAFLPDFEVRFTPRSEKYQEVIENSMAVLPDVLSISATP
Protein: Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3) (P41155)
Organism: Mus musculus (Mouse)
Function: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 3
- Lymphotoxin-alpha
- Tumor necrosis factor ligand superfamily member 13B
- Tumor necrosis factor receptor superfamily member 5
- CD40 ligand
- Tumor necrosis factor ligand superfamily member 14
- C-C chemokine receptor type 7
- Tumor necrosis factor ligand superfamily member 11
- Tumor necrosis factor receptor superfamily member 13C
- Tumor necrosis factor receptor superfamily member 1B
Sequence:
MGTRGLQGLGGRPQGRGCLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGRRVEKIIGSGAQAQKRLDDSKPSCILPSPSSLSETPDPRLHPQRSNASRNLASTSQGPVAQSSREASAWMTILSPAADSTPDPGVQQLPKGEPETDLNPELPAAHLIGAWMSGQGLSWEASQEEAFLRSGAQFSPTHGLALPQDGVYYLYCHVGYRGRTPPAGRSRARSLTLRSALYRAGGAYGRGSPELLLEGAETVTPVVDPIGYGSLWYTSVGFGGLAQLRSGERVYVNISHPDMVDYRRGKTFFGAVMVG
Protein: Transcription factor IIB (Q38EY4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSTTTDFVGRNCPHCSAVDSLQTDDVMGEVACTACALVVAMGLEENVFTRYNENATYEDVDHHRERNANPTAATSAAGSLSAADPHMSSTSSKVVLHPTMLNCMRGLHKKAVLPEPVLDRGIELARAFVGGRRARGQRVERQPDVAAACLMIAAEEAQQPLPLAEVRCLDSSLGDVELRRADIVRELHLEDSERRLRDTFADNLLVKYILKLGLQVSLYLPHCKRLLTALGRVEALAGLTVADRVTTALLLARTAQTLSWEQGTHISKGKECDLGMEAIYANFSSKAHLEVTKVNKIMHLAVDVLPLIQAAFQDCGEPTAGKRKVDKNSEPEASGSTKRVKREET
Protein: HtrA serine peptidase 2 (A0A8I6AI60)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAALKAGRGANWSLRAWRALGGIFWRKGPLLAPDLRALLTSGTPDPQARMTYGTPSLPARVPLGVLASRANLTSGTPDLWVRLTVGTPGSSDQEDCGSPGSRRREWLAVALGAGGAVLLLLWGWGRGPSTVLAAVPAPPPTSPRSQYNFIADVVEKTAPAVVYIEILDRHPFSGREVPISNGSGFIVASDGLIVTNAHVVADRRRVRVRLPSGDTYEAMVTAVDPVADIATLRIQTKFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSWFGISGSQRRYIGVMMLTLTPRAGLRPADVILAIGEKMIQNAEDVYEAVRTQSQLAVRIRRGPETLTLYVTPEVT
Protein: Thiol-dependent reductase 1 (A4I8P2)
Organism: Leishmania infantum
Interaction partners:
- Uncharacterized protein
- Putative As/Sb Reductase
- NADH-ubiquinone oxidoreductase 20 kDa subunit,mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH:ubiquinone oxidoreductase 78 Kd subunit-like protein
- Putative NADH-ubiquinone oxidoreductase, mitochondrial
- non-specific serine/threonine protein kinase
- Mitochondrial carrier protein-like protein
- non-specific serine/threonine protein kinase
Sequence:
MAARALKLYVSATCPFCHRVEIVAREKQVSYDRVAVGLREEMPQWYKQINPRETVPTLEVGNADKRFMFESMLIAQYLDNSGAPAGALMGSSAAQRHQIEFFLAQVGDFIGAAHGLLRDPLSGEKRKAMDDNAAYVDGLLAANQTTGPYYCDGEFTMADVALVPFLVRLKPALMYYAGYDVFCKAPRMKALWAAAAQRASVRETSPTAAQCIENYRHLVPESAPMMGANGGHVLYSNLFCPFVDRARLASELRKFQMHIVEVPLHPQPEWYKYINPRDTVPALFTPSGEAVHESQLIVQYIDCVATKGSALVPRGDAEKEYEVGFFVENAGYFVGGLMSWIIRGGEDAKAELQWAAGELEQQLAKHPFGEGPFFGGKRMNAGDVAILPFLVRAKAFMPEFSGGYDLFAHFPLLNGLAEAGMATPEAKSVFRTLEEYKEHIRKRQRRAQSG
Protein: 26S proteasome regulatory subunit 8 homolog B (26S proteasome AAA-ATPase subunit RPT6b) (26S proteasome subunit 8 homolog B) (Regulatory particle triple-A ATPase subunit 6b) (Q94BQ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- 26S proteasome regulatory subunit 6A homolog A
- 26S proteasome regulatory subunit 4 homolog B
- 26S proteasome regulatory subunit 6A homolog B
- 26S proteasome regulatory subunit 7 homolog A
- 26S proteasome non-ATPase regulatory subunit 7 homolog A
Sequence:
MAAVGVEARPPVTAMEETCNVKGAAAKQGEGLNKYYLQHLDELQRLQREKSYNLNRLEAQRNELNSRVRMLREELQLLQEPGSYVGEVVKVMGKNKVLVKVHPEGKYVVDIDKSIDITKLTPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSARMESGSGNGDSEVQRTMLELLNQLDGFEASNKIKVLMATNRIDILDQALLRPGRIDRKIEFPNPNEESRFDILKIHSRKMNLMRGIDLKKIAEKMNGASGAELKAVCTEAGMFALRERRVHVTQEDFEMAVAKVMKKDTEKNMSLRKLWK
Protein: Possible dehydrogenase (O69693)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable alcohol dehydrogenase adh
Sequence:
MKAVTCTNAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARLHCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPRRGTPVVAMPLLRRGNKEVHGIGLSTMAPGAYAERLVVEQSLTFPVPNGLAPEIAALTEPMAVGWHAVRRGEVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVERLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVCMGSDHIRPAMAINKEINLRFVLGYTPLEFRDTLHMLADGKVNAAPLITGTVGLPGVAAAFDALGDPEAHAKIMIDPKSNAASPQPFRVE
Protein: UBX domain-containing protein (Q580U3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ubiquitin fusion degradation protein, putative
- MPN domain-containing protein
- Proteasome subunit beta
- Katanin p60 ATPase-containing subunit A-like 2
- Elongin-C
- UBX domain-containing protein
- ATPase, putative
- Cell division cycle protein, putative
- ATPase, putative
- Valosin-containing protein homolog
Sequence:
MAMCDCSETVAISLLSEANFDVDYAYHLHMSRTQGADESVTSLHGTSPQGEAPHLQEPELPHASYVVNRLDGGGGYVGGNYPHERDFLLDEVESEQDLLDSVFPIPAFVHRSPEPFDTFCTDSLNRDQWVILSFVLNDFTGFCVNRDIWRSEDLLEVLSMFSIYQTTADVGEGPGLAHGYRLDVEKDIPTLLIINPITRVKETRIPINVHEATIESYEVKNALLTFVGEKGSPNQWEECRLRGTYENASPVLHTENSREYVDVEETSIPFSEPEAGRRDEANEGVVAQPPQILAVDISPYEVPAEVGSAFTLRCRLPKEQLTLRLKPEMPVLLLLKYLSTRLYFSQSTAFPGGVPNCSLRVGFPPKDLIVEDGEVQLGTCPGLRSGDTVVLHIH
Protein: Rho guanine nucleotide exchange factor 40 (Protein SOLO) (Q8TER5)
Organism: Homo sapiens (Human)
Function: May act as a guanine nucleotide exchange factor (GEF).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16143467}. Note=Concentrated in the perinuclear region.
Interaction partners:
Sequence:
MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLAKVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLALKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL
Protein: Chemosensory protein B 38b (Q7KT14)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIRGLVILVLALANTWATDYNALIDDEGIYVKCSEAPAGTLGPRDVFNIDNMVMHMEPEGIYVSGNMTVKLNFLPSDRISARFSVMHYERGSWQPTMFNLHSPNFCEVMFDEDQYWFKYWFRYIRNKEEIREKCLKVKDTVLVYDEFLMVLHLENVNTSNLQGRYKAVITLEAFDEHNVRRPSSLCVEIRGDLERVT
Protein: DOK4 protein (Docking protein 4) (A4IFJ7)
Organism: Bos taurus (Bovine)
Interaction partners:
- Transmembrane protein 184B
Sequence:
MATNFNDIVKQGYVKMKSRKLGIYRRCWLVFRKSSSKGPQRLEKYPDEKSVCLRGCPKVTEISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEEWYKTLSVECLGSRLNDISLGEPDLLAPGVQCEQTDRFNVFLLPCPNLDVYGECKLQITHENIYLWDIHNPRVKLVSWPLCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQIYQRVHSATLAIAEQHKRVLLEMEKNVRLLNKGTEHYSYPCTPTTMLPRSAYWHHITGSQNIAEASSFAGEGYAAAQASSETDLLNRFILLKPKPSQGDSSEARAPSQ
Protein: Doublesex- and mab-3-related transcription factor 1A (xDmrt1) (DMRT1-alpha) (Q3LH63)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and germ cell proliferation. Acts both as a transcription repressor and activator.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
Sequence:
MQNNEEPYSKTRNSGQHPSGVHTKKSPRLPKCARCRNHGYASPLKGHKRYCMWRDCQCKKCSLIAERQRVMAAQVALRRQQAQEEELGISHPIHLPIAAELLIKKEHGGSSSCLMLENSSTQTTSTPTSGSTASSEGKVLIQEIPSITSRGHMESTSDLVMDSPYYSNFYQPPLYPYYNNLYNYPPYQMAMAAESTSGNDMGGISGPPLKNNHRNHPAAYVPSQSGNQWQMKNRENRFPGHSGSSQFRMHSYYPPYLGQSVPNPACVPPFLTFEEIPSYSEAKASVLSPPSSQDSGVISLSSNSPVSNESTKAVAEQEPNSESSLFTVTTAAENGE
Protein: Exported protein family 3 (O97474)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MNYFLSLFNVSLFFLLIFKYSYKNIVKKDLQDKFNKSIITINIASRILTENNKKWYKKYIYTSIFSGNKNPQKRERKNEEENQKDNTKVDNDNNMENEMENHIDDSIDDPMDDLMNDKWEHHNSLEDRIKEYYTLTDPSDGEENNSFFKKLKLIMNILDEVHSDLLINNSVTDGSIFSPELVPISVLSTMTLACPPIGTVTLPYITNRINFLNRYEGQNIHTEHDLKIFK
Protein: Carboxypeptidase (CP) (EC 3.4.17.-) (P86516)
Organism: Sabellastarte magnifica (Feather duster)
Function: Carboxypeptidase that catalyzes the release of hydrophobic and acidic C-terminal amino acids.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P00732}.
Interaction partners:
Sequence:
AFDLNDFNTLEDTYDQMNVFQLSEAGLTHEGRDMKSWIDSLTHCRSHLDEDVFMFKRNEPDSGSACVGTDLNRSSNNPCSDTYGGSGPASALETRHSYSQQYEDELNQRQRYEPSGTTVNNLLNKDAGSIYSYTPELR
Protein: Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase) (Q8NFU5)
Organism: Homo sapiens (Human)
Function: Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate. Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis. Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12027805}.
Interaction partners:
- Inositol-pentakisphosphate 2-kinase
- Inositol-tetrakisphosphate 1-kinase
- Multiple inositol polyphosphate phosphatase 1
- Inositol-trisphosphate 3-kinase B
- Inositol-trisphosphate 3-kinase A
- Inositol-trisphosphate 3-kinase C
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
- Inositol polyphosphate 5-phosphatase K
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Sequence:
MATEPPSPLRVEAPGPPEMRTSPAIESTPEGTPQPAGGRLRFLNGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYYGIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEKIQQQVSKYPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRFFHNGYCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSSQPTTTKLNDRTLAEKFLSKGQLSDTEVLEYNNNFHVLSSTANGKIESSVGKSLSKMYARHRKIYTKKHHSQTSLKVENLEQDNGWKSMSQEHLNGNVLSQLEKVFYHLPTGCQEIAEVEVRMIDFAHVFPSNTIDEGYVYGLKHLISVLRSILDN
Protein: T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (Q76NU3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit epsilon
- Uncharacterized protein
- T-complex protein 1 subunit delta
- Uncharacterized protein
- Uncharacterized protein
- T-complex protein 1 subunit alpha
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MLSMIKQQGAAADSRRGQALLLNISAGKGLQNVLKTNLGPRGTLKMLVGGGGDIKLTKDGKVLLHEMQIQHPTAALIARTATAQDDITGDGTTTNVITIGELLKQSERYLQENIHPRIIAEGFELAKDRCLAFLEEFKQTSQDTLDRELLISIAKTSLRTKLPADLADQLTEQVVDALLLIHKPEQPLDLFMVEIMTMQHRTDGHCSLIKGLVLDHGTRHPDMPKKLTNCFILTCNVSLEYEKTEVNANFLYKDHETRSRMIDGEHKLVAAKCRQIIELKNHVCDTPDKNFVVINQKGIDPICLDMLAKAGIMGLRRAKRRNMERLTLACGGTAMNSLEDLTPDCLGHADLVYEQTLGEEKYTFVEGVKNPFSCTVLIKGPTKHQIEQIKDALRDGLRAVKNTIEDKCVVPGGGAFQIAAYADLMKFKETITGRTKLGIQAFADALLVVPKTLAQNSGFDPMDTIIKLQEEYAKGHIVGLDVESGEPMDPVSEGIFDQYSVLKQVYRSSPVIASQLLLIDEIIKAGKGMRGSSVPEGQE
Protein: Synaptonemal complex central element protein 1 (Q9D495)
Organism: Mus musculus (Mouse)
Function: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.
Subcellular location: Nucleus {ECO:0000269|PubMed:15944401}. Chromosome {ECO:0000269|PubMed:15944401, ECO:0000269|PubMed:16968740}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements. {ECO:0000269|PubMed:15944401}.
Interaction partners:
- Synaptonemal complex central element protein 2
- Testis-expressed protein 12
- Synaptonemal complex protein 1
- Synaptonemal complex central element protein 3
- Synaptonemal complex protein 3
- Cohesin subunit SA-3
- HORMA domain-containing protein 1
- Meiotic recombination protein REC8 homolog
- Protein SIX6OS1
- Structural maintenance of chromosomes protein 1B
Sequence:
MATRPQPLGMEPEGSADLLHGPEGARGQYGSTQKIEDLMDMVKKLQKVGSLEPRIEVLINRINEVQQAKKKASEELGEAQTVWDNLQKELDLLREEKVRLKDILNRKEETLRIMQLHCQEKESEAQRKHSMLQECKERISFLNSQIDKEKAKLRKLRLDFEEHLETLMSQHKDTLEFHKPEHLTKEMCVLDSSKEQLLKEEKLMKVKLEDVRQRLCALGGPEGSSSLIEGLFLRSHEAAAAMQMFKDENKKAEEFLEAAAQQHEQLQQRCHQLQQKRQRLKEELEKHGVQILAHSTQNEEDSSWRMASPKPVEVHEETAQDQERPSSRT
Protein: Opacity protein opA52 (opA31) (Q04875)
Organism: Neisseria gonorrhoeae
Function: Implicated in a number of adherence functions. OPA proteins are implicated in pathogenesis and are subject to phase variation.
Subcellular location: Cell outer membrane.
Interaction partners:
Sequence:
AGEDHGRGPYVQADLAYAYEHITRDYPDAAGANKGKISTVSDYFRNIRTHSIHPRVSVGYDFGGWRIAADYARYRKWHNNKYSVNIKELERKNNKTSGGDQLNIKYQKTEHQENGTFHAVSSLGLSTVYDFRVNDKFKPYIGVRVGYGHVRHGIDSTKKTKNTLTAYHGAGTKPTYYDDIDSGKNQKNTYRQNRSSRRLGFGAMAGVGIDVAPGLTLDAGYRYHYWGRLENTRFKTHEASLGVRYRF
Protein: Branchpoint-bridging protein (A0A0R4IBT0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367126}.
Interaction partners:
- Splicing factor 3A subunit 2
- Splicing factor 3A subunit 1
- Splicing factor 3a, subunit 3.
- Cell division cycle 5-like protein
- Probable ATP-dependent RNA helicase DDX46
- Splicing factor U2AF subunit
- U2 snRNP auxiliary factor large subunit
- Splicing factor 3B subunit 1
- U1 small nuclear ribonucleoprotein C
- Pleiotropic regulator 1.
Sequence:
MATGANATPLGKLHPSIGAKRGFDSGPGPGLMPPPGPSVPFPLQNFQPPQLSNPGFPQFPGAVSSALSNPIVVGQQSQAGGGDFGQKKRKRSRWSSETPDQKTVIPGMPTVIPPGLTRDQERAYIVQLQIEDLTRKLRTGDLGIPVNPEDRSPSPEPIYNSEGKRLNTREYRTRKKLEEERHSLITEMVGLNPEFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECCAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSTEPRSITNTTLCTKCGGAGHISSDCKFTSSFAPRPGEPPQSAQDKARMDKEYLSLMAELGEAPVPSSGGGHNNAPPSGPRPSGPNNNQPPPNRPPWMNSGPTDNRNFHGMHQGPGGPHNFPPPMPNMGGPPMPPNPNGMPPPWMQPPPPPMGQGPAPPGHPMGLLPPPMGMMPPPPPPPNNQPPPPPSGPLPPWQQQAPPPPPTSSMATSAPMPWQQNTTTTSTPATGNLPPWQQPQQTAASASQPPPPMGNPSMVPPPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPMDPNFVTMMGIPGMPPYGMPPAPPPPPPQS
Protein: Centromere protein C (AtCENP-C) (CENP-C) (CENP-C homolog) (Q66LG9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
Subcellular location: Chromosome, centromere {ECO:0000269|PubMed:15329494}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15161939}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:15329494, ECO:0000269|PubMed:26124146}. Note=Present at the centromeric regions, especially in the kinetochore domain, throughout the cell cycle. {ECO:0000269|PubMed:15161939, ECO:0000269|PubMed:15329494}.
Interaction partners:
- Kinetochore-associated protein KNL-2 homolog
- Histone H3-like centromeric protein CENH3
- Mitotic spindle checkpoint protein BUBR1
- Mitotic spindle checkpoint protein MAD2
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Structural maintenance of chromosomes protein 4
- Mitotic checkpoint protein BUB3.1
- Structural maintenance of chromosomes protein 3
- Putative pectinesterase 11
Sequence:
MADVSRSSSLYTEEDPLQAYSGLSLFPRTLKSLSNPLPPSYQSEDLQQTHTLLQSMPFEIQSEHQEQAKAILEDVDVDVQLNPIPNKRERRPGLDRKRKSFSLHLTTSQPPPVAPSFDPSKYPRSEDFFAAYDKFELANREWQKQTGSSVIDIQENPPSRRPRRPGIPGRKRRPFKESFTDSYFTDVINLEASEKEIPIASEQSLESATAAHVTTVDREVDDSTVDTDKDLNNVLKDLLACSREELEGDGAIKLLEERLQIKSFNIEKFSIPEFQDVRKMNLKASGSNPPNRKSLSDIQNILKGTNRVAVRKNSHSPSPQTIKHFSSPNPPVDQFSFPDIHNLLPGDQQPSEVNVQPIAKDIPNTSPTNVGTVDVASPFNDSVVKRSGEDDSHIHSGIHRSHLSRDGNPDICVMDSISNRSSAMLQKNVDMRTKGKEVDVPMSESGANRNTGDRENDAEINEETDNLERLAECASKEVTRPFTVEEDSIPYQQGASSKSPNRAPEQYNTMGGSLEHAEHNQGLHEEENVNTGSASGLQVENAPEVHKYSHKQTNKRRKRGSSDSNVKKRSKTVHGETGGDKQMKTLPHESRAKKQTKGKSNEREEKKPKKTLTHEGKLFSCRKSLAAAGTKIEGGVRRSTRIKSRPLEYWRGERFLYGRIHESLTTVIGIKYASPGEGKRDSRASKVKSFVSDEYKKLVDFAALH
Protein: RBP2 (Q71B03)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLRICVALCVLATCWAQDCQVSNIQVMQNFDRSRYTGRWYAVAKKDPVGLFLLDNVVAQFSVDGSGKMTATAQGRVIILNNWEMCANMFGTFEDTPDPAKFKMRYWGAAAYLQSGNDDHWVIDTDYDNYAIHYSCREVDLDGTCLDGYSFIFSRHPTGLRPEDQKIVTDKKKEICFLGKYRRVGHTGFCESS
Protein: C-1-tetrahydrofolate synthase, cytoplasmic (EC 1.5.1.5) (EC 3.5.4.9) (EC 6.3.4.3) (F5H2F4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKPGKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTITIHLQEATLKVWPVSIQAHWELGSISKPREVSPCPEDLKLIVGVSPEVIFSLNSHHV