wanglab/gogpt-training-data huggingface dataset:
Protein: Protein eak-4 (Enhancer of akt-1 null 4) (G5EBR8)
Organism: Caenorhabditis elegans
Function: Together with eak-6 and sdf-9, negatively regulates dauer larva formation downstream of the insulin-like receptor daf-2 and in parallel with age-1, pdk-1 and akt-1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16839187}; Lipid-anchor {ECO:0000305|PubMed:16839187}; Cytoplasmic side {ECO:0000269|PubMed:16839187}.
Interaction partners:
- Tyrosine-protein phosphatase non-receptor type eak-6
- Enhancer of AKt-1 null
- Protein sdf-9
- MTOR-associated protein MEAK7
Sequence:
MGQCLAVHRRIMASQEFPNIPQPESQCHDAFIRYSPGRYERRAARSQVDYYLLPQAPRLMTEDLDKKEFQRLYDARCELVECPAGRRAMQLDVQIYADRYEATLNKILETSQELDKGLEDIFQAYTKDDPLADKVMNCRLTVDEMGRVYEHFFRESAWNLDSFVEYRKNLARDAYLLLADLKIAIQRLGMHFNPNFEDAQVKVDFQIMQAEQIIFHFKRTYRDALKHNPDSITEFVEDELEDPGTPL
Protein: XK-related protein 9 [Cleaved into: XK-related protein 9, processed form] (Q5GH62)
Organism: Mus musculus (Mouse)
Function: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25231987}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Phospholipid-transporting ATPase 11C
Sequence:
MKYTKCNFMMSVLGIIIYVTDLVADIVLSVRYFHDGQYVLGVLTLSFVLCGTLIVHCFSYSWLKADLEKAGQENERYFLLLHCLQGGVFTRYWFALRTGYHVVFKHSDRKSNFMEEQTDPHKEAIDMATDLSMLRLFETYLEGCPQLILQLYAFLECGQANLSQCMVIMVSCCAISWSTVDYQIALRKSLPDKNLLRGLWPKLMYLFYKLLTLLSWMLSVVLLLFVDVRVALLLLLFLWITGFIWAFINHTQFCNSVSMEFLYRIVVGFILVFTFFNIKGQNTKCPMSCYYTVRVLGTLGILTVFWIYPLSIFNSDYFIPISATIVLALLLGIIFLGVYYGNFHPNRNVEPQLDETDGKAPQRDCRIRYFLMD
Protein: PAN domain protein (Q9XUE5)
Organism: Caenorhabditis elegans
Interaction partners:
- LiPocalin-Related protein
- Leucine-rich repeat-containing protein let-4
- NOmpA Homolog
- Papilin
- EGF-like domain-containing protein
- Leucine-rich repeat-containing protein let-4
- Inactive angiotensin-converting enzyme-related protein
- Leucine-rich repeat-containing protein egg-6
- Uncharacterized protein
- Nucleolar GTP-binding protein 2
Sequence:
MWGVIFLLLSIVPAAQSVFECSSHETTAFVRIPRARLDGTPVVISTAGHDLTCAQYCRNNIEPTTGAQRVCASFNFDGRETCYFFDDAATPAGTSQLTANPSANNFYYEKTCIPNVSAHEACTYRSFSFERARNTQLEGFVKKSVTVENREHCLSACLKEKEFVCKSVNFHYDTSLCELSVEDKRSKPTHVRMSEKIDYYDNNCLSRQNRCGPSGGNLVFVKTTNFEIRYYDHTQSVEAQESYCLQKCLDSLNTFCRSVEFNPKEKNCIVSDEDTFSRADQQGQVVGKDYYEPICVAADLSSSTCRQQAAFERFIGSSIEGEVVASAQGVTISDCISLCFQNLNCKSINYDRTASSCFIYAVGRQDANIKANPSMDYYEFNCESQFGGMALCTNEGIRFIVNTKEPYTGAIYAAERFSTCSQVVENAKQISITFPPPTVSSDCGTVIRDGKMEALVVVSLDGVLPHQVTTEWDRFYRVSCDVSMDKMVKEGSVVVTTIYEASSQNTTVLDVATPPPVSAELQILNQLEEPLHKASIGDPLLLVITSEQAGPHNMMVTECTATRVGGFGDTVPFTLIENGCPRYPALVGPVEQDFDKNRLKSDLRAFRLDGSYDVQIVCSIMFCAGPNGCPVSNCLDSGTNELFMSHGRKKRSADLEAGETEEKLSAIIRVFAKGEDEEEMEMANNTMMTSMSDSTELLCIAEPFFVSSVVSLSVLCFALSAIIAIWGCHSLHSKPVKQVAA
Protein: Slit homolog 3 protein (Slit-3) (Slit3) (Q9WVB4)
Organism: Mus musculus (Mouse)
Function: May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Roundabout homolog 2
- Roundabout homolog 1
- Roundabout homolog 4
- Roundabout homolog 3
- Netrin-1
Sequence:
MALGRTGAGAAVRARLALGLALASILSGPPAAACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSIIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGVTGVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTIGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNANSLSCPSACSCSNNIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIPKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFVPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRNRFSSECFMDLVCPEKCRCEGTIVDCSNQKLARIPSHLPEYTTDLRLNDNDISVLEATGIFKKLPNLRKINLSNNRIKEVREGAFDGAAGVQELMLTGNQLETMHGRMFRGLSSLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHMAWLGRWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCVETVVRCSNRGLHALPKGMPKDVTELYLEGNHLTAVPKELSAFRQLTLIDLSNNSISMLTNHTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPESMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCSQDPVEQYRCTCPYSYKGKDCTVPINTCVQNPCEHGGTCHLSENLRDGFSCSCPLGFEGQRCEINPDDCEDNDCENSATCVDGINNYACLCPPNYTGELCDEVIDYCVPEMNLCQHEAKCISLDKGFRCECVPGYSGKLCETNNDDCVAHKCRHGAQCVDEVNGYTCICPQGFSGLFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKLQKQPAVGSNSPLYLGGIPTSTGLSALRQGADRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCRHGLCRSVEKDSVVCECHPGWTGPLCDQEARDPCLGHSCRHGTCMATGDSYVCKCAEGYGGALCDQKNDSASACSAFKCHHGQCHISDRGEPYCLCQPGFSGHHCEQENPCMGEIVREAIRRQKDYASCATASKVPIMECRGGCGSQCCQPIRSKRRKYVFQCTDGSSFVEEVERHLECGCRACS
Protein: Collagen alpha-1(XI) chain (P12107)
Organism: Homo sapiens (Human)
Function: May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Interaction partners:
- Collagen alpha-2
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-2
- Lumican
- Collagen alpha-3
- Thrombospondin-2
- Collagen alpha-1
Sequence:
MEPWSSRWKTKRWLWDFTVTTLALTFLFQAREVRGAAPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSILFTVKPKKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSERAIVDTNGITVFGTRILDEEVFEGDIQQFLITGDPKAAYDYCEHYSPDCDSSAPKAAQAQEPQIDEYAPEDIIEYDYEYGEAEYKEAESVTEGPTVTEETIAQTEANIVDDFQEYNYGTMESYQTEAPRHVSGTNEPNPVEEIFTEEYLTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTEGMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDEEMSYDNNPFIKTLYDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG
Protein: 2OG-Fe dioxygenase family protein (Q0GPY6)
Organism: Agrobacterium vitis (Rhizobium vitis)
Interaction partners:
Sequence:
MQGNISVLKHSDPANVTNIDVCQQLHDFDFVFLEGNNFLDIIHQSHFSTQDIADFQASWDDLKPDTYMADGGKYRLRRHATLTGAPKGGPVSLEKHQPHFQTTSYNPLNGGIERHFEPVLASTIENPVMQAIFSFASSTFGALSPFSTWHMELHQFRIEAVQTGGKPTPEGVHRDGVDFVLMVLIKRHNIVGGETSILDRDGVKLAEFTLMDPFDAAIVNDERVAHGVTPITKLDPDQQGLRDVLVLTFRRK
Protein: ERBB-3 BINDING PROTEIN 1 (AtEBP1) (Proliferation-associated protein G2p) (AtG2) (Protein CELL-PROLIFERATION-RELATED) (AtCPR) (Q96327)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Required for expression of cell cycle genes such as CYCD3-1, RNR2A and CDKB1-1. Promotes, in a dose- and auxin-dependent manner, organ growth by stimulating both cell proliferation and expansion, via the regulation of RBR1 levels.
Subcellular location: Nucleus {ECO:0000269|PubMed:15689342}.
Interaction partners:
- Nuclear/nucleolar GTPase 2
- 60S ribosomal export protein NMD3
- Pescadillo homolog
- Ribosome production factor 2 homolog
- Ribosome assembly factor mrt4
- Probable ribosome biogenesis protein RLP24
- Large ribosomal subunit protein uL18y
- AT5g04600/T32M21_200
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL23z
Sequence:
MSSDDERDEKELSLTSPEVVTKYKSAAEIVNKALQVVLAECKPKAKIVDICEKGDSFIKEQTASMYKNSKKKIERGVAFPTCISVNNTVGHFSPLASDESVLEDGDMVKIDMGCHIDGFIALVGHTHVLQEGPLSGRKADVIAAANTAADVALRLVRPGKKNTDVTEAIQKVAAAYDCKIVEGVLSHQLKQHVIDGNKVVLSVSSPETTVDEVEFEENEVYAIDIVASTGDGKPKLLDEKQTTIYKKDESVNYQLKMKASRFIISEIKQNFPRMPFTARSLEEKRARLGLVECVNHGHLQPYPVLYEKPGDFVAQIKFTVLLMPNGSDRITSHTLQELPKKTIEDPEIKGWLALGIKKKKGGGKKKKAQKAGEKGEASTEAEPMDASSNAQE
Protein: BBG-LP29 (Q15K32)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
TRSESLVVKALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMKQLPLGPVKICFA
Protein: Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial (IDH-III) (Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3) (O81796)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Performs an essential role in the oxidative function of the citric acid cycle.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14671022}.
Interaction partners:
- Peroxisomal isocitrate dehydrogenase
- Cytosolic isocitrate dehydrogenase
- Isocitrate dehydrogenase, chloroplastic/mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Aconitate hydratase 1
- Isocitrate dehydrogenase catalytic subunit 5, mitochondrial
- Isocitrate dehydrogenase catalytic subunit 6, mitochondrial
- Aconitate hydratase 2, mitochondrial
- Aconitate hydratase 3, mitochondrial
Sequence:
MARRSVSIFNRLLANPPSPFTSLSRSITYMPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLGNMRKVPEEVIESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVEQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAALE
Protein: trypsin (EC 3.4.21.4) (D3GE88)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
- Solute carrier family 43 member 3b
- Transmembrane protein 104
- Tumor necrosis factor, alpha-induced protein 8-like protein 2 B
- Regulator of G-protein signaling 18
Sequence:
MKCILGGFLLTCVLCWTEAIIGEMDERWKSSSTSVNGKCILDRDESKYTGKVSVTVSGRICAPWNSIQGSRYSAFKNCYHNYCRNPDDWTQPWCVVKKRNRYVREYCNIPQEAIKPVKRPPTPEPIKQDTELTCGERRLDRQTKIIGGLRSTVESQPWMAAIFKGDGFICGGTLITPCWVLTAAHCFPTGKRTQINRYSVVLGKNAINETDPVKEQKFTVSRLVIHEDFDYSTENYTHDIALLKIEDCNGQCAVKTKTVRTACLPPFQQMLPVGFYCEIAGYGRYQKGTFKFSRYLKQTEVKLISQKVCQRTYYNKDEVNENMLCANGRDWKTDACQGDSGGPLVCEVNNIMFLFGIISWGKECAEKNQPGVYTQVSNYNQWISQHTGLPRYTAGSRYPQKD
Protein: Unconventional myosin-Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC) (P47807)
Organism: Gallus gallus (Chicken)
Function: Could play an important role in morphogenesis and function of intestinal microvilli.
Interaction partners:
- Uncharacterized protein.
- Calmodulin
- Calmodulin, striated muscle
- Uncharacterized protein.
- Actin, cytoplasmic 1
- Plastin-1
Sequence:
MEATTSLLDAAAVGDLVMLDPLSEESLLRTLQERFSRGEIYTYIGEVVISVNPYKPLPIYTPEKVEEYHNCNFFAVKPHIYAIADDAYRSLRDRDRDQCILITGESGAGKTEASKLVMSYVAAVSSKGEEVDKVKEQLLQSNPVLEAFGNAKTIRNDNSSRFGKYMDVEFDFKGDPLGGVISNYLLEKSRIVRHVKGERNFHIFYQLLAGGSAQLLQQLKLRPDCSHYGYLNHEKSVLPGMDDAANFRAMQDAMAIIGFAPAEVTALLEVTAVVLKLGNVKLSSCFQASGMEASSITEPRELQEISQLIGLDPSTLEQALCSRTVKVRDESVLTALSVSQGYYGRDALAKNIYSRLFDWLVNRINTSIQVKPGKQRKVMGVLDIYGFEIFQDNGFEQFIINYCNEKLQQIFILMTLKEEQEEYVREGIQWTPVEFFDNSIICDLIENSKVGILAMLDEECLRPGTVNEDTFITKLNQIFASHKRYESKETLNAKHVTDVSLPLRCFRIHHYAGKVTYNVTGFIEKNNDLLFRDLSQAMWAARHTLLRSLFPEGDPQRPSLKLPPTTGSQFKASVATLMKNLYSKNPNYIRCIKPNDTKTAMLFTPDLVLAQVRYLGLMENVRVRRAGYAFRQLYQPFLERYKMLSRKTWPRWTGGDREGAEVLLAELKFPPEELAYGHTKIFIRSPRTLFDLEKRRQQRVAELATLIQKMFRGWCCRKRYQLMRKSQILISAWFRGHMQRNRYKQMKRSVLLLQAYARGWKTRRMYRRYFRSDACTRLSNFIYRRMVQKYLMGLQKNLPPMAVLDRTWPPAPYKFLSDANQELKSIFYRWKCKKYREQLTPQQRAMLQAKLCASELFKDKKALYAQSLQQPFRGEYLGLTQNRKYQKLQAVAKDKLVMAEAVQKVNRANGKTVPRLLLLTTEHLVLADPKAAQPKMVLSLCDIQGASVSRFSDGLLALHLKETSTAGGKGDLLLVSPHLIELVTRLHQTLMDATAQALPLSIADQFSTRFPKGDVAVTVVESAKGGGDVPVCKKRGSHKMEILVH
Protein: Toucan, isoform I (M9PC13)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLAIVILMTGGVGVCINPNRSDQKTAFKVVATSVKGGRSYSKDSHKSSHTDLSLMCNASSSRPSNSASGSGSPKLLANTQLHKRLNGTLASTAAIATPIKGVATKSGATNKLQQSAKTKSTASIKSPAIVGVSEESLRSGVDQTELQELNNGQSATGCPTPPMARDSKRTSIGNELPCETEAKLKRCEDQQDPQASTTASPLPMINPQEQEASGQVKEATITTANEPNALSLPDEISNSVSSTTMLATPRVDIAAQYPVLKPFTENGELDCARLAKFFQDTQFERKEEQRQILGLSVMVQFMSKELDAVACKENKHQCARTKGTLEKTILLLQHTQKDCERLREDLEDKGLEWIQRQQEKEYLHRTELKQAEEKLMEVQLRAKLKFCELESQLRAKDEESKQAQEAYRMEVSHKLALKQEHLRTAEQKIQELQTRLQQVETEEQGHREELIRKENIHTARLAEANQREQDLIDRVKSLTKELNTLKANKEHNERDLRDRLALSQDEISVLRTSSQRRSPCTSLPDNASAELNRLTSEADSLRCVLELKQAEISALSKAKADLIHESEERLKLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQKAYKYESIKRTRLTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNSLSSHSRCSLGRSGLEIAVTTSSPTSPVMKGMIERNDSVSWTLEIEDESFKGNTSKIVRRAGSLRSNNERCPIQRRQTLTSNGHSNGSATNGGSSPAHPNPLSQSMSATALLRSSSNSGESEGRPLSRARSKSMCIKASATSSAVCESSGQRKKPQDELSLADWPEDIPLCSSSPQAPGIEMRPRSSTMKLMSSEAKKFQEIQESAGEAMVSGANSEDESCSASSEDIMRSSSASSTASGGSLSKRPKQPPSRMSIEEALPCTPMEVSWSEDAADANGLA
Protein: Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7) (Q16549)
Organism: Homo sapiens (Human)
Function: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Seems to be localized intracellularly to the trans Golgi network. {ECO:0000250}.
Interaction partners:
- Integral membrane protein 2C
Sequence:
MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC
Protein: Glutathione S-transferase 1-1 (EC 2.5.1.18) (EC 4.5.1.1) (DDT-dehydrochlorinase) (GST class-theta) (P67805)
Organism: Drosophila simulans (Fruit fly)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity (By similarity).
Interaction partners:
- GD18821
- GD20579
- GD18820
- glutamate--tRNA ligase
- Bifunctional glutamate/proline--tRNA ligase
- GD16640
- GD12789
- glutathione transferase
Sequence:
MADFYYLPGSSPCRSVIMTAKAVGVELNKKLLNLQAGEHLKPEFLKINPQHTIPTLVDNGFALWESRAIQVYLVEKYGKTDSLYPKCPKKRAVINQRLYFDMGTLYQSFANYYYPQVFAKAPADPEAFKKIESAFEFLNTFLEGQEYAAGDSLTVADIALVASVSTFEVAGFEISKYANVNKWYENAKKVTPGWEENWAGCLEFKKYFE
Protein: Regulator of G-protein signaling 5 (RGS5) (O08850)
Organism: Mus musculus (Mouse)
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O15539}. Membrane {ECO:0000250|UniProtKB:O15539}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein G
Sequence:
MCKGLAALPHSCLERAKEIKIKLGILLQKPDSAVDLVIPYNEKPEKPAKAHKPSLEEVLQWRQSLDKLLQNSYGFASFKSFLKSEFSEENLEFWVACENYKKIKSPIKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSPRSFDLAQKRIYALMEKDSLPRFVRSEFYKELIK
Protein: E3 ubiquitin-protein ligase NEURL1 (EC 2.3.2.27) (Neuralized-like protein 1A) (m-neu1) (m-neuralized 1) (Neuralized1) (RING-type E3 ubiquitin transferase NEURL1) (Q923S6)
Organism: Mus musculus (Mouse)
Function: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:22153079}; Peripheral membrane protein {ECO:0000269|PubMed:22153079}. Perikaryon {ECO:0000269|PubMed:22153079}. Cell projection, dendrite {ECO:0000269|PubMed:22153079}. Postsynaptic density {ECO:0000269|PubMed:22153079}. Note=Colocalized with JAG1 at the cell surface (By similarity). Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons. {ECO:0000250}.
Interaction partners:
- E3 ubiquitin-protein ligase MIB2
- E3 ubiquitin-protein ligase MIB1
Sequence:
MGNNFSSVSSLQRGNPSRASRGHPQNLKDSIGGSFPVPSHRCHHKQKHCPPTLSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTVDPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRCEADEARLSVSLCDLNVPGADGDDGAPPAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARLEHGRDERALVFTSRPVRVAETIFIKVTRSGGGRAGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFSLHGAITQVRILGSTIMTERGGPSLPCSPASTPTSPSALGIRLSDPLLSTCGSGPLGGSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYSCGLRLKKALHACCPICRRPIKDIIKTYRSS
Protein: Homeobox protein Hox-C11 (Homeobox protein Hox-3.7) (P31313)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-C10
Sequence:
MFNSVNLGNFCSPSRKERGADFGERGSCTSNLYLPSCTYYVPEFSTVSSFLPQAPSRQISYPYSAQVPPVREVSYGLEPSGKWHHRNSYSSCYAAADELMHRECLPPSTVTEILMKNEGSYGGHHHPSAPHAAPAGFYSSVNKNSVLPQAFDRFFDNAYCGGGDAPAEPPCSGKGEAKGEPEAPPASGLASRAEAGAEAEAEEENTNPSSSGSSHSATKEPAKGAAPNAPRTRKKRCPYSKFQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLSRDRLQYFSGNPLL
Protein: Uncharacterized protein P35G2.04c (Q9P799)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MISNSSIEDRINKNEAYIAKFFEIFSKNDKIRFHGVSLDRKALDSFMVRNNFKKRFVSGINLPILIRLHFYKKLFTILWLTVRTVALLSHARNIQCLIQESDGDAKDVARSIYITTAEFRNYLLTEKGFYVTTRSISHFRAILDSIRYPFGKDHASKNMELLPITYDLSFCTVFHGYLTSILEAYEFFRGVFKKYKAPLSSNFIAIGKTTDESNFSQLHHYFQKFDERIRRILHLISQELDGYCRIAKQ
Protein: Progonadoliberin-1 (Progonadoliberin I) (G1MQ97)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MEKARKISVGVLLFTTSVAICLAQHWSYGLQPGGKRNVENLVESFQEIANEMENLGEAQKAECPGSYQHPSLSNLKETMVSSVDFLLLLWENLRPVQAGKAWGGGV
Protein: T19F6.7 protein (O22978)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT3g07470/F21O3_18
Sequence:
MASEGVVVVGGEREGAEIVYGAEECYKQSLELLEELGFPKGVMPLKNLVECGRVRATGYVWMKQDTPYEHFFEATNTRVSYGLEVTAYVDKCCMKKMTGVKSKQMFLWVPIVEMSMEEPKSKKIYFKTPMGIGRSFPVTGFMDEEEKRNFYLENPKN
Protein: Prohibitin 1 (P84173)
Organism: Gallus gallus (Chicken)
Function: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P35232}. Nucleus {ECO:0000250|UniProtKB:P35232}. Cytoplasm {ECO:0000250|UniProtKB:P35232}. Cell membrane {ECO:0000250|UniProtKB:P35232}.
Interaction partners:
- Prohibitin-2
- SPG7, paraplegin matrix AAA peptidase subunit
- AFG3 like matrix AAA peptidase subunit 2.
- Stomatin like 2.
- Stomatin like 3
- ATP-dependent zinc metalloprotease YME1L1
- PHB domain-containing protein.
- Uncharacterized protein.
- Stress-70 protein, mitochondrial
- Mitochondrial-processing peptidase subunit alpha
Sequence:
MAAKVFESIGKFGLGLAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDTVVGEGTHFLIPWVQKPIIFDCRSRPRNIPVITGSKDLQNVNITLRILFRPVTAQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSEDLTERAATFGLILDDVSLTHLTFGKEFTEAVEMKQVAQQEAERARFIVEKAEQQKKAAVISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPSGQSVLLQLPQ
Protein: Retinoic acid early transcript 1E (Lymphocyte effector toxicity activation ligand) (NKG2D ligand 4) (N2DL-4) (NKG2DL4) (RAE-1-like transcript 4) (UL16-binding protein 4) (Q8TD07)
Organism: Homo sapiens (Human)
Function: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Subcellular location: Membrane {ECO:0000269|PubMed:15240696}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.
Interaction partners:
- NKG2-D type II integral membrane protein
- UL-16 binding protein 5
- UL16-binding protein 6
- Hematopoietic cell signal transducer
- T-cell surface glycoprotein CD8 alpha chain
Sequence:
MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIILGAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS
Protein: EG:118B3.2 protein (O77431)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIKLKSLFRRGQGNSSSHSSNSSHKQQQNSSNNNRQKSQSSTSLNTAHEQQQQHSITAATTKFYAHQETASYERGVDVGDEGALLLTNQQQEQRRQQQQLLQQPQSNTLPQKKSKLKGQKQPKLLPVQQPHSNAPEPHDPQQPLMTSLAAVPQASATGSSSNSNINNNNALAALQDGGAAAAAAADFYQQLAAAATATATATSANGSNTSADSPVSSFPAAAAAVAVAAVAASSYQQQQQQQQLLNNEQQQQQLLEANNKMQELHKQMERFRSEQMQLETRITELLPYQSEVAKLKGDLVKMQSLQEKSQMEIGNLKYENESLRNRLRDVVNSPLSDAEKHQIIQDSQRLHSSAPASIALPSTHDAHDGTPCLTPDWDKQSSSSEISVACLQDKIIQMEETHYSTNEELQATLQELADLQTQLTDTQTENERLAEEKDVLFQSLCRQTEKLNESRTQISTLQELLLRDTKQPAPEVSASEREQKLLDLIKTSQEEREAVLLKQEELGAELAEMKQAREAGQLELQRQRERIALLDSQLDAANAERRQGEAQFSQAMEEISQRAIEISRLSTLLENARSKIEELEADLSRGDKTDLSEVLDVARKEKDALEERVAELQDQCSRSQAELRRLRDQLSGLTEECKVVKNNAKCAVSHLEYRLEQLQRDKDKIAGEWQALEERVAELQVQCKCHQEDKAQLQSLLAETQRHLGDVQLKLGEAECRLDQETQLRRKEAEEWQQFQADLLMTVRVANDFKTEALSAREQLVLDNKTQKEKIRLLEQQLEKLTKQQMQQSETPQSVLSTVQREMEMATRRSKLSFSRQDSRLSVKTLIESIENNKAQGKADESESHYSSTSSLNSGTPDLGTTPIIFPPSSDWHESIRLPVLQSTNLHVNVGNEAGAGQGTNTSSGSGGDLASTTKATLPLRDQQQLAITSTQSQVQNVSQPSTPATPSSAGSSSSGGLPFGNVSKSFISGERKDPLNMLAKNGGSKRNALLKWCQNKTVGYRNIDITNFSSSWNDGLAFCAILHSYLPDRIPYDQLTPANKRRNFSLAFAAAESVGIGTTLVSFHGQQKLNLFILILI