wanglab/gogpt-training-data huggingface dataset:
Protein: AT26020p (Q8MZ90)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLQRNRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKSLKLCDLYKNYFTSIRLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLEKRLRALLTTTNESEIINDIVDCHEFNVYYQGKFRKVNEFQVLDHKLKRSYRSKVFIFDKCIIYTEIKGKNLLFHGRYPCEHIGISAKTKSFTLYYERRKQQECEFTADPVQIAIWLDLIRDMINNYANEERQKLQERYSRENDHLHRKAPSFSLYRDSNRFSSDSGIGNIWIMPKADEDTISNRTTWYAAT
Protein: PDZ and LIM domain protein 7 (Q6P7E4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- T-box transcription factor 4
- GAS2-like protein 3
- Actinin alpha 3b
- T-box transcription factor TBX5-A
Sequence:
MNIYCVTLNGPAPWGFRLQGGKDFNTPLTVSRLTPGGKAAQAGVGVGDWVVSIFDANAEEMTHVEAQNKIRAATDSLKLTLSRAFHPAGGEQKDSLTSSSSQPKYSFAPSTAINKMARPFSASPGSGSAGPVIKPVSYALKPALSSPHNGHGVAPCPVTVKSKPADKHDAVQAPAKAPVSSGPACRPPWVTDPGFADRYHPDKSSTVVTQHTQPLQPTPMQNRSSILQAAQQSPAHSSTATPLCAACSKIIRGRYVVALGRSWHPEEFMCCQCKRLLDEGGFFEEKGSIYCSKCYDNRYSPNCAKCKKIITGEIMHALKMTYHVQCFLCAACKLPIRNQAFYMEEGEPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGYSWHDTCFVCAICQINLEGKTFYSKKDKPLCKSHAFSPL
Protein: Glyoxylate/succinic semialdehyde reductase 2, chloroplastic (AtGLYR2) (AtGR2) (SSA reductase 2) (EC 1.1.1.79) (EC 1.1.1.n11) (F4I907)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the NADPH-dependent reduction of glyoxylate to glycolate as well as succinic semialdehyde (SSA) to gamma-hydroxybutyrate in vitro. May function in redox homeostasis and play a role in oxidative stress tolerance by detoxifying glyoxylate and SSA generated in glycolate metabolism and GABA metabolism, respectively.
Subcellular location: Plastid, chloroplast stroma {ECO:0000305|PubMed:18495639}.
Interaction partners:
- Gamma-aminobutyrate transaminase POP2, mitochondrial
- Glyoxylate/hydroxypyruvate reductase HPR3
- Succinate-semialdehyde dehydrogenase, mitochondrial
- Isocitrate lyase
- Glyoxylate/hydroxypyruvate reductase A HPR2
- Glycolate oxidase 3
- Peroxisomal
- Glycolate oxidase 2
- Malate synthase
- Glyoxylate/succinic semialdehyde reductase 1
Sequence:
MPLVSLSFASSSSKAMALCSICPRIPLRFRPKPISPFLSKPQICLAYRVYSSLQSTTPSTRDELGTVSIGFLGMGIMGSPMAQNLIKAGCDVTVWNRTKSKCDPLVGLGAKYKSSPEEVTATCDLTFAMLADPESAIDVACGKNGAIFGISSGKGYVDVSTVDVASSILISKQIKDTGALFLEAPVSGSKKPAEDGQLIFLTAGDKPLYEKAAPFLDIMGKSKFYLGEVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHQQKDMRLALGLAESVSQSTPIAAAANELYKVAKSYGLSDEDFSAVIEALKAAKSREA
Protein: Uncharacterized protein (Q4GYU7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MESGKNAHRLNRIFRKPKTMVAPRAWRPAADGEGERQQPFSGVSLQRINAMISELSEEERTRALAQQDPPTVVQEELAKRAARFGLTIERADAGNNEKTASSEITPEVQAVFQRRMERFGQSAAEEAMQKRVARFGNAATSAEGPGVELKLSEADREAMQRRQSRFGG
Protein: Mitchondrion orf173 (Q8HCM5)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MSGGAKRSSLNQRFYEIEIDSFLDIWIDGWIYLDIQISFAISPKSLIWPGNKALLWAQEAKGMSSAASPPHFFISPCPFRMRFARHWRFALLLFLHWRVRMDFAVLSQRKWKGLYHIEMSIRFPPQMRWGISHLCPFIFMKGIKARPGSRRSNNRRGAPQYTIARSNWESYYT
Protein: BmK-YA precursor [Cleaved into: BmK-YA 1 (Enkephalin-like peptide 1); BmK-YA 2 (Enkephalin-like peptide 2); BmK-YA 3 (Enkephalin-like peptide 3); BmK-YA 4 (Enkephalin-like peptide 4)] (Q9Y0X6)
Organism: Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Function: Synthetic BmK-YA activates human opioid receptors in vitro, with highest activity on the delta-type/OPRD1 receptor (EC(50)=2.5 uM) and lower activity on mu-type/OPRM1 and kappa-type/OPRK1 receptors (EC(50)=17 uM and 30 uM, respectively).
Subcellular location: Secreted {ECO:0000269|PubMed:22792309}.
Interaction partners:
Sequence:
MIFHQFYSILILCLIFPNQVVQSDKERQDWIPSDYGGYMNPAGRSDEERQDWIPSDYGGHMNPAGRSDEERQDWIPSDYGGHMNPAGRSNEERQDWIPSDYGGYMNPAGRSDEERQDWIPSDYGGHMNPAGRSNEERQDWIPSDYGGYMNPAGRSDEERQDWIPSDYGGHMNPAGRSDEERQDWIPSDYGGYMNPAGRSD
Protein: Telomere replication protein EST3 (Q5A7P3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity).
Subcellular location: Nucleus {ECO:0000305}. Chromosome, telomere {ECO:0000305}.
Interaction partners:
- Telomerase reverse transcriptase
- Est1p
- Cdc13p
- ATP-dependent DNA helicase II subunit 2
Sequence:
MFRSVSLSSLIPFLIIVSIAMQRPENDVPMIMQSSWLVNEVIKSINSNGQYINALIKKDFQPTVLPVSFILRILKFTATTDSKDITAVLADSTHKIFAIFLFFPAIVDFENKYHHRMTYNTRSCLIRIHKANLKFMDKSTVKKCYGRKSDGGLAIAVLEVLEFDIFFKDQYSFINSIENRLKYVYDDVEYNQLCGKKKHKPEYEDLMCDI
Protein: Protein misato (O01939)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
Sequence:
MDYTREILTFQFGTYANYVGTHFWNQQEANFRYGDESEQVAEEQLPNNDILYREGRNDLNRTTYTPRLLSVDLSGTLGHLPVTGELYGNFVQRDEELLPLSTGEELEQVRKRAEESGVCSPEQLEVQEQSKASISEYQRDLLKNAVVPEKNYQLAATANSWVDFLYARYHPRTLNVLPGLIRDPTAQALGTYSAGTEMWQEVSFNEEFCDRIRLYVEECDGLQGFHVLFDIDDGFGGLAGKCLEHLNDEYSRASFALPLHYPRITSYPQADTRLSHSIRVVNNVLGYHQLSEQALMFTPLSTLETIWRNNNLKSRSLPGLQWETDNLYQTSALLAAFFDTATLSYRLRQTPESLLRFCECVTPAGRKMTAAGLALPFGLREGQDLIEFLDQSGDHALLTQLTPGCEPGTSYVVQSVTARGIPAERLKRPRELAGDQLRMAAYSCDSISHMLQLYYQCTYHGSVTNAAATPLPLKTQLPFPYEMFAAGISRDGYRLPEGAERETGSRVDSAPMLAAVQNSTKLGEHLDNVHAQSHRVQLAKLQAYSNSGLERDEYDTALDQLLEFRDLYADSQYL
Protein: Protocadherin gamma-B5 (PCDH-gamma-B5) (Q9Y5G0)
Organism: Homo sapiens (Human)
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Protocadherin gamma-B3
Sequence:
MGSGAGELGRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDITDRPVPSDPQAELQFYLVVALALISVLFLLAVILAVALRLRRSSSPAAWSCFQPGLCVKSGPVVPPNYSQGTLPYSYNLCVAHTGKTEFNFLKCSEQLSSGQDILCGDSSGALFPLCNSSESTSHPELQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Protein: Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) (Q8BVQ5)
Organism: Mus musculus (Mouse)
Function: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity).
Interaction partners:
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Leucine carboxyl methyltransferase 1
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
- Serine/threonine-protein phosphatase 2A activator
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Sequence:
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFTPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRGHGETKVKNSEDLSAETMAKDVGNVVEAMYGDLPPPVMLIGHSMGGAIAVHTAAANLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC
Protein: AMP deaminase (EC 3.5.4.6) (H0Y360)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASYPSGSGKPKAKYPFKKRASLQASTAAPEARGGLGAPPLQSARSLPGPAPCLKHFPLDLRTSMDGKCKEIAEELFTRSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLRAKQDFLKTDSDSDLQLYKEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDAAKSVVRALFIREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPPALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVNVLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELRLSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLPLFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRKAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKVRAQQAARRAGEPLMEEYSIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYETLCQELALITQAVQSEMLETIPEEAGITMSPGPQ
Protein: Sorting nexin 14 (D6RJG9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVPWVRTMGQKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYIHILMIFWSFVAGVVTFYCSLGPDSLLPNIFFTIKYKPKQLGLQELFPQGHSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRITLRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKARQKVKNTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLIREILSGSVFLPSLDFLADPDTVNHLLIIFIDDSPPEKATEPASPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQFCLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESIDKIRFDPFIVEEIQRIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKLNRGSLSLDDFRNTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGVAEGEDDFIEEGIVVMEDDSPVEAVSTPNTPRNLAAWKISIPYVDFFEDPSSERKEKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSRPELTILSPTSENNKKLFNDLFKNNANRAENTERKQNQNYFMEVMTVEGVYDYLMYVGRVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLQCKLEQLFQEHRLVSLITLLRDAIFCENTEPRSLQDKQKGAKQTFEEMMNYIPDLLVKCIGEETKYESIRLLFDGLQQPVLNKQELFPELNKVQKEVTSVTSWM
Protein: Mitochondrial inner membrane m-AAA protease component YTA12 (EC 3.4.24.-) (EC 3.6.-.-) (Tat-binding homolog 12) (P40341)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:7929327, ECO:0000269|PubMed:8681382}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial inner membrane m-AAA protease component YTA10
- Prohibitin-1
- Inner membrane mitoribosome receptor MBA1, mitochondrial
- Prohibitin-2
- Lon protease homolog, mitochondrial
- Mitochondrial metalloendopeptidase OMA1
- Mitochondrial inner membrane protein OXA1
- mRNA-binding protein PUF3
- Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3
Sequence:
MLLLSWSRIATKVVRRPVRFRSYYGLTHIKSLHTQYRLLNRLQENKSGNKNEDNNEDAKLNKEIPTDEEVEAIRKQVEKYIEQTKNNTIPANWKEQKRKIDESIRRLEDAVLKQESNRIQEERKEKEEENGPSKAKSNRTKEQGYFEGNNSRNIPPPPPPPPPKPPLNDPSNPVSKNVNLFQIGLTFFLLSFLLDLLNSLEEQSEITWQDFREKLLAKGYVAKLIVVNKSMVKVMLNDNGKNQADNYGRNFYYFTIGSIDSFEHKLQKAQDELDIDKDFRIPVLYVQEGNWAKAMFQILPTVLMIAGIIWLTRRSAQAAGGSRGGIFGLSRSKAKKFNTETDVKIKFKDVAGCDEAKEEIMEFVSFLKEPSRYEKMGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFYFVSGSEFVEMFVGVGAARVRDLFKTARENAPSIVFIDEIDAIGKARQKGNFSGANDERENTLNQMLVEMDGFTPADHVVVLAGTNRPDILDKALLRPGRFDRHINIDKPELEGRKAIFAVHLHHLKLAGEIFDLKNRLAALTPGFSGADIANVCNEAALIAARSDEDAVKLNHFEQAIERVIGGVERKSKLLSPEEKKVVAYHEAGHAVCGWYLKYADPLLKVSIIPRGQGALGYAQYLPGDIFLLTEQQLKDRMTMSLGGRVSEELHFPSVTSGASDDFKKVTSMATAMVTELGMSDKIGWVNYQKRDDSDLTKPFSDETGDIIDSEVYRIVQECHDRCTKLLKEKAEDVEKIAQVLLKKEVLTREDMIDLLGKRPFPERNDAFDKYLNDYETEKIRKEEEKNEKRNEPKPSTN
Protein: Tropomyosin-1, isoforms 9A/A/B (Cytoskeletal tropomyosin) (Tropomyosin II) (P06754)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Subcellular location: [Isoform 9A]: Cytoplasm, cytoskeleton.
Interaction partners:
- KxDL motif-containing protein CG10681
- Tropomyosin-2
- GEO12017p1
- Degringolade, isoform A
- Kinesin heavy chain
- Calmodulin-related protein 97A
- Yuri gagarin, isoform B
- Dynamin
- LIM and SH3 domain protein Lasp
- Cortactin, isoform A
Sequence:
MDAIKKKMQAMKVDKDGALERALVCEQEARDANTRAEKAEEEARQLQKKIQTVENELDQTQEALTLVTGKLEEKNKALQNKKKTTKMTTSIPQGTLLDVLKKKMRQTKEEMEKYKDECEEFHKRLQLEVVRREEAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEERMDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLKSLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDIGDDLDTAFVELILKE
Protein: Protein tyrosine phosphatase, receptor type, G (A0A8I6AZZ3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGTLQESRQGSSVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGSHQSPIDILDHHARVGEEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSVNGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHVFLQWLTPRS
Protein: L-2-amino-4-chloropent-4-enoate dechlorinase/desaturase (EC 4.5.1.-) (4-chloro-allyl-L-glycine acetylenase) (L-propargylglycine synthase) (G8XHD7)
Organism: Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057) (Streptomyces cattleya)
Function: Involved in the biosynthesis of terminal alkyne-containing amino acids such as L-propargylglycine (Pra) and L-beta-ethynylserine, that are produced as antibiotics by S.cattleya. Catalyzes gamma-elimination of chloride from 4-chloro-allyl-L-glycine (also named L-2-amino-4-chloropent-4-enoate), followed by an isomerization, to form the terminal-alkyne product L-propargylglycine.
Interaction partners:
Sequence:
MSAGSPAEPRPVPGSVHSVSVSIPDVRSVIGFESGDPATLRRIAWGYPRFRTHPYVARVAALVAGAVGGRAQDLVLTRSVRAAEAAAAYAGLAPGAVFEASGVRGVRVAEDDPALAAVRGHVQHTGAHLTSREAEDVLLEAGLIEARQAEEAVSEEPAEAVRSALATAYGAGDPADVSLHNSGMNAVAAAVAAVTDLQRPAGRRRWIQLGWIFFDTMSLLDKRLFGTDHVTVPDPFDLAALSRVVAAHPGQLAGIIAELPSNPSLRCPDVPALREIADRAGCALVLDATIATPHNVDVLGYADVVCESLTKYATGSADVLMGAAVVGSASPWAAQLREGLRRFGDVPYHRDAARVAARIRDYGDRMKRVNAGAVALAGFLERQSAVRAVSWPYDAASQANYRKVERLSDAPGGLLMVDLRVPLERVYDRLAVAKGPSFGAEFTMASPQIFIAHFDLLSTPEGRAELRSRGLHRDMLRISVGVEDPELIAEVFRDAFDGAG
Protein: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase (HMP-P synthase) (Hydroxymethylpyrimidine phosphate synthase) (EC 2.-.-.-) (No message in thiamine protein 1) (Thiamine biosynthesis protein 3) (Thiamine pyrimidine synthase) (P36597)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Thiamine thiazole synthase
- Probable thiamine biosynthetic bifunctional enzyme
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2
- Thiamine repressible genes regulatory protein thi1
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1
- DNA polymerase epsilon catalytic subunit A
- Thiamine pyrophosphokinase
- Thiamine-repressible acid phosphatase pho4
- Thiamine repressible genes regulatory protein thi5
Sequence:
MSTNKITFLTNWEATPYHLPIFLAQTRGYYEREGIEVAILEPTNPSDVTALIGSGKVDMGLKAMIHTLAAKARGYPVTSFGSLLNEPFTGLITLKGNGINDFKDIKGKRIGYVGEFGKIQLDDLCSKFGLSPSDYTAIRCGMNIAPAIINGEIDGGIGIECMQQVELERWCVSQGRPRSDVQMLRIDRLANLGCCCFCTILYIAHDEFIAKHPDKIKAFLRAIHSATLDMLKDPVQTYKEYIHFKREMGSELHREQFERCFAYFSHDISNVPRDWNKVTNYSKRLGIIPQDFEPNCTNGYLTWELDPDEKDPMGKQEAIAEIQDEIKQKGGVFSGNSLRYVEPANL
Protein: Comb gap (Combgap, isoform A) (Combgap, isoform D) (LD05357p) (Q7KHK4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCAAQNPPPFGYTWGFADNGNRAAESVLEISPNINYTVSGESMPYLLSTDGSLAVQKDVKGLTAGGKNNVVRRMFVVNDPSFPPGTQRVITAGGASTVVKKQDNNQQVLSLDKNCDILPGISVQVQKVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVCECGKAFFQKNHLMLHQRQHLETKPAISQQQVC
Protein: RNA helicase (EC 3.6.4.13) (Q9V3C4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Gem-associated protein 5
- Survival motor neuron protein
- Serine-threonine kinase receptor-associated protein
- Gem-associated protein 4a
- Gem-associated protein 2
- Enhancer of mRNA-decapping protein 3
- GH10889p
- Lsm10
- FI05704p
- U6 snRNA-associated Sm-like protein LSm1
Sequence:
MEREIAHSLAGGEERSSDVAPGQVKTFEELRLYRNLLNGLKRNNFVTPTKIQAAAIPMALAKMDLIIQSKSGTGKTLIYVIAVVQSFNPNINQPHAMIVVPTRELAIQVQDTFFHLCKSFRDFKCSAFIGGTDVAKDRKRMNESRVIIGTPGRLLHLYENRVFDVSKLRLLVLDEADQLYQTKSLQHTVSKLIEAMPKNRQIIACSATYDQNLDERLAKVMDKPMLISNSERATVLLGIRQFVYELPQQNNSVEEMRLKLQILGQIFNQLPYEQAIIFASSQMRADSYKNYLTASGIDCHLISGAMEQSERLHVFEGYRNFTMRILVATDLMARGVDSPHANLVINIDPPQDHVTYLHRIGRAGRFGSKGIAITFIASKKESQRFREMSKKIATAWSVLEFPKEPMPNEFNFWDFEKYNFDYYIKEENPLQEMPMPIKENRSKENVDASSVDLENLQKDQDGKRRDPDKLPVALENVETQKELELENLPESSHNNKNLRVKEKEIVRQGKLKETNSKAGGSKTNKTERRKKSNTPSKLQKQITEVQQTPEITVNKYYMQEDIQRTADGKEYHPVNGAGNHQVPSKSNQKPVEFISPELTPTLTPLELTQEPSPTTVTPPAPPANSINNKTYCLAAPTQTSSMTIQNMVISNTVDDASSISSDSMVVCGYHSDRSYDTYYATSDEEEIWNRLMSKQRRQLKSKRGHGKRRVILYKKVFPKLKANVKRKLKKRMSSSCRSKKAHHLRKRHVYKNISLLPHMNLCHLLQKFTNQERFLKRLHKYAKNQFIDNARVGFLLDKLYKSILEMYYNSAKERKKHFKEAMKESLKSIDNYESQESSESEEEEEEEKDLKNKLSVHVTNQMDIPPMPQAAVEIGSGSESDTEDSQEYGEGEEIIVDDEDDGSDGGPNSSSGFVESQESVSSGIDTSVYETESTGASGNNSSAFFISDDESDTESLTDSEAGSNVSATGSSSQRSSVASSTYESSDDDSVTVTNVSSMQNAQSLWLQTFNMQYQFIASHVAKNLQNYY
Protein: Translation initiation factor IF-1, chloroplastic (O82499)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:11251102}.
Interaction partners:
- Small ribosomal subunit protein uS10c
- Translation initiation factor IF3-1, mitochondrial
- Small ribosomal subunit protein uS10z/uS10x
- Small ribosomal subunit protein uS14c
- Small ribosomal subunit protein uS10y
- Eukaryotic translation initiation factor 2 subunit alpha
- Eukaryotic translation initiation factor 2 subunit alpha homolog
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein uS14m
- Eukaryotic translation initiation factor 3 subunit A
Sequence:
MLQLCSTFRPQLLLPCQFRFTNGVLIPQINYVASNSVVNIRPMIRCQRASGGRGGANRSKPAKPQVKEGSNKTVIEGLVTESLPNGMFRVDLENGDNILGYICGKIRKNFIRILPGDKVKVEMSVYDSTKGRIIFRMSSRD
Protein: Forkhead box protein P4 (Fork head-related protein-like A) (Q8IVH2)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor that represses lung-specific expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Interaction partners:
- Forkhead box protein P2
- Heart- and neural crest derivatives-expressed protein 1
- Forkhead box P1
- Forkhead box protein P3
- Forkhead box protein P1
- Heart- and neural crest derivatives-expressed protein 2
Sequence:
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNNDSKQSASAVQVPVSVAMMSPQMLTPQQMQQILSPPQLQALLQQQQALMLQQLQEYYKKQQEQLHLQLLTQQQAGKPQPKEALGNKQLAFQQQLLQMQQLQQQHLLNLQRQGLVSLQPNQASGPLQTLPQAAVCPTDLPQLWKGEGAPGQPAEDSVKQEGLDLTGTAATATSFAAPPKVSPPLSHHTLPNGQPTVLTSRRDSSSHEETPGSHPLYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHLHMRPSEPKPFSQPLNPVPGSSSFSKVTVSAADSFPDGLVHPPTSAAAPVTPLRPPGLGSASLHGGGPARRRSSDKFCSPISSELAQNHEFYKNADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEREYQKRRPPKMTGSPTLVKNMISGLSYGALNASYQAALAESSFPLLNSPGMLNPGSASSLLPLSHDDVGAPVEPLPSNGSSSPPRLSPPQYSHQVQVKEEPAEAEEDRQPGPPLGAPNPSASGPPEDRDLEEELPGEELS
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (E7EX48)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDRE
Protein: Uncharacterized protein YLL056C (Q12177)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Small ribosomal subunit protein uS19
- Putative uncharacterized protein YLL059C
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- Glutathione S-transferase 2
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein eS21B
- Small ribosomal subunit protein uS15
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MKVFITGASGFIGSAVLSELISSGHEVVGLARSDEAAAKIKSIDPAAKILRGDLKDLEILKKGATESDGVIHLGFVHDFKNFEQCCEIDRQATVAMLESLKGSNKPFLYTNGTLSLRPNKVANEQDGIDEDSKILRAVTEQVALSYKDKGVSARIVRLPFSVHGKGDKAFVPILMNIAKAAGKSGYVGQGTNAWAAVHRLDTAPLFRLVLEKGKTGQVYHCVGEQGIPFKDIARVIGEILNVPVASIPVDDAESHFGFLTCFVTRDGPVSSEGTRKELGWQPQQIGLLEDIRANYSLN