wanglab/gogpt-training-data huggingface dataset:
Protein: Geranylgeranyl diphosphate reductase, chloroplastic (EC 1.3.1.83) (Geranylgeranyl reductase) (Q9ZS34)
Organism: Nicotiana tabacum (Common tobacco)
Function: Catalyzes the reduction of geranylgeranyl diphosphate to phytyl diphosphate, providing phytol for both tocopherol and chlorophyll synthesis.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- magnesium-protoporphyrin IX monomethyl ester
- Prolycopene isomerase, chloroplastic-like.
- Prolycopene isomerase, chloroplastic-like.
- Magnesium-chelatase subunit ChlI, chloroplastic
- Mg-protoporphyrin IX chelatase
- Electron transfer flavoprotein subunit beta
- Electron transfer flavoprotein subunit beta
- Homogentisate geranylgeranyltransferase-like
- Homogentisate geranylgeranyltransferase-like
- Magnesium-chelatase subunit ChlH
Sequence:
MASIALKTFTGLRQSSPENNSITLSKSLPFTQTHRRLRINASKSSPRVNGRNLRVAVVGGGPAGGAAAETLAKGGIETFLIERKMDNCKPCGGAIPLCMVGEFDLPLDIIDRKVTKMKMISPSNVAVDIGQTLKPHEYIGMVRREVLDAYLRDRAAEAGASVLNGLFLKMDMPKAPNAPYVLHYTAYDSKTNGAGEKRTLEVDAVIGADGANSRVAKSINAGDYEYAIAFQERIKISDDKMKYYENLAEMYVGDDVSPDFYGWVFPKCDHVAVGTGTVTHKADIKKFQLATRLRADSKITGGKIIRVEAHPIPEHPRPRRLQDRVALVGDAAGYVTKCSGEGIYFAAKSGRMCAEAIVEGSEMGKRMVDESDLRKYLEKWDKTYWPTYKVLDILQKVFYRSNPAREAFVEMCADEYVQKMTFDSYLYKKVAPGNPIEDLKLAVNTIGSLVRANALRREMDKLSV
Protein: Thiamine thiazole synthase (EC 2.4.2.59) (Q58018)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
Interaction partners:
- Phosphomethylpyrimidine synthase
- Bifunctional thiamine biosynthesis protein ThiDN
- Uncharacterized protein MJ0597
- Uncharacterized protein MJ0596
- Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
Sequence:
MVNLMNIKDIKLNADETKTTKAILKASFDMWLDIVEADVVIVGAGPSGLTCARYLAKEGFKVVVLERHLAFGGGTWGGGMGFPYIVVEEPADELLREVGIKLIDMGDGYYVADSVEVPAKLAVAAMDAGAKILTGIVVEDLILREDGVAGVVINSYAIERAGLHIDPLTIRSKVVVDATGHEASIVNILVKKNKLEADVPGEKSMWAEKGENALLRNTREVYPNLFVCGMAANASHGGYRMGAIFGGMYLSGKLCAELITEKLKNKE
Protein: Probable endonuclease LCL3 (EC 3.1.-.-) (Long chronological lifespan protein 3) (P53153)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 2
Sequence:
MREGDSNSKKSADVAVLSIILTGSTLTLIYTYKRYLTQFKRTNDIPRRIFRKHWLYGKVTSVGDGDNFHFFHMPGGIRGGWGWLRPVPQMIKNDSTAEKLVGDSRNMRFFNFNWITHGRSTKSKIQKAKSQFLKLNVPYKNRKNLPTIPIRLCGIDAPERAHFGNPAQPFGNEALIWLQNRILGKKVWVKPLSIDQYNRCVARVSYWDWFGGWKDLSLEMLKDGLAVVYEGKVNTEFDDREDKYRYYEFLARSRKKGLWIQNKFETPGEYKKRI
Protein: Erythrocyte membrane protein band 4.1 like 2 (A0A2R8Y5B3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
SEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKTVSMCPPSPLIHRTSSFSPNLLPVPEMDLLSDISEEDPFGEADQITLDSLEHLSTGEISEQGDSEVAMPDLVLDSAIAPSQPDCPSPIHGKTLKAADDSDSEFGYFSFSFSKCFPSGFPSLLDEDGYLAFPSLPKVWVSFLPAGVQHYVPITSPSFIPSLILIFGLLLSASQSVPFSLAFSLPLALSLCYLEAKAASFNVSYDCDLNDKLEEEEVVAGMPT
Protein: Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) (P31652)
Organism: Rattus norvegicus (Rat)
Function: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11709063, ECO:0000269|PubMed:15627510, ECO:0000269|PubMed:16870614, ECO:0000269|PubMed:1948036, ECO:0000269|PubMed:8601815}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000269|PubMed:16870614}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:16870614}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q60857}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q60857}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q60857}. Note=Could be part of recycling endosomes (PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (PubMed:11709063). Density of transporter molecules on the plasma membrane is also regulated by serotonin (By similarity). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity). {ECO:0000250|UniProtKB:P31645, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:11709063, ECO:0000269|PubMed:16870614}.
Interaction partners:
- 5-hydroxytryptamine receptor 1A
- 5-hydroxytryptamine receptor 2A
- Synaptic vesicular amine transporter
- 5-hydroxytryptamine receptor 1B
- Amine oxidase [flavin-containing] A
- 5-hydroxytryptamine receptor 2B
- Tryptophan 5-hydroxylase 1
- 5-hydroxytryptamine receptor 1D
- Tryptophan 5-hydroxylase 2
- 5-hydroxytryptamine receptor 2C
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
Protein: Ribonuclease HI (RNase HI) (EC 3.1.26.4) (Ribonuclease H) (RNase H) (P0A7Y4)
Organism: Escherichia coli (strain K12)
Function: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer. Involved in production of retron derived msDNA (a branched RNA linked by a 2',5'-phosphodiester bond to a single-stranded DNA). Strain K12 / MG1655 does not have retrons, however they can be expressed in this strain which requires this enzyme (tested with retron Ec86).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- DNA polymerase III subunit epsilon
- Ribonuclease HII
- DNA topoisomerase 1
- DNA polymerase I
- Crossover junction endodeoxyribonuclease RuvC
- Chromosomal replication initiator protein DnaA
- Pyrroline-5-carboxylate reductase
- ATP-dependent DNA helicase RecG
- Protein RecA
- Flap endonuclease Xni
Sequence:
MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV
Protein: Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (Peptidase M) (p67) (p67eIF2) (Q7SXK1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03175}. Note=About 30% of expressed METAP2 associates with polysomes. {ECO:0000256|HAMAP-Rule:MF_03175}.
Interaction partners:
Sequence:
MADVQTQEPQSAVQTLILPNGDSHLPKEDTEPVDETGKKKKKKKKKGKAAAVENHDGEGDTDIAKVTKQLDQQTLEEQEKEDEAEEDGEEGDSAGKKKKKKKKKKGPKVQTDPPSIPICELYPSGVYAKGQECEYPPVQDGRTAASRTSNEEKKFLDQANEDMWNDFRQAAEAHRQVRKYVQSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNHCAAHYTPNAGDPTVLQYDDVCKIDFGTHINGRIIDCAFTVTFNPKYDKLLEAVKDATNTGIKCAGIDVRLCDIGESIQEVMESYEVDLDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGMVHDDMECSHYMKNFEVGHVPIRLPRAKHLLNVVNENFGTLAFCRRWLDRLGETKYLMALKNLCDLGIIDPYPPLCDTKGCYTAQFEHTILLRPTCKEVVSRGDDY
Protein: Nose resistant to fluoxetine protein 5 (Protein nrf-5) (Q93796)
Organism: Caenorhabditis elegans
Function: Plays a role in the uptake of a range of molecules including phosphatidylserine, lipids and xenobiotic compounds from the intestine to surrounding tissues. Possesses lipid transfer activity. Mediates transport of lipids from intestine to reproductive tract. Binds phosphatidylserine. Plays a role in efficient clearance of cell corpses by mediating phosphatidylserine appearance on phagocytic cells, thus promoting phagocytic engulfment of apoptotic cells. Vital for embryonic development.
Subcellular location: Secreted {ECO:0000269|PubMed:22727700}.
Interaction partners:
- Transthyretin-like protein 52
- ABC transporter ced-7
- Nose resistant to fluoxetine protein 6
- Nose resistant-to-fluoxetine protein N-terminal domain-containing protein
- Fatty acid-binding protein homolog 8
- Cell death protein 6
- Lipid-binding serum glycoprotein C-terminal domain-containing protein
Sequence:
MSRNFHIFFLLVSIIQVGNSADSSEITHKPAGIYVRLNQKAVDYVADLASDALPAILNNLSPPDIVTDMAKITKLHISNVAKPNLSAKFIDGKGVAYNISLASFRASAYAEISVFVWSYEGDFTAELRELSIESELHFDYNGTTTVNASVCNVTHSELSLVFPPGSSLSALQSEIKGQIVSALRDAVCTTAVEALTFVMAQKPIPPESPNYQKPEAGDPNGFSVAELGASLCQVDTVNGFEDSEQEEGNVETTVAPTPDDDNSTLTTEETQKSYWGVDLSVNHPPTFTDEDMIIGLDGGILFNGWKADSAQQLQILNKTRLDKKMVGILLSEYIPNTLFHHIYMYDLGNFKHRYTPSSLPKILQKLSKAVCSKCYVEVSANLTEQPILQIDAHLGARVQLSGNVSIMFHGREQLHDVLHANTKLHVTLKPTVRHSRIFGDVSLTNVDVNVFDLGLGGPLAAPIEKLFSFVVPRVLWPQVKKRLRFAMNRRGVKLPIFCGVELEHTELDFVDHAVLLNTDFSFDLPLFLAKFKKYLDAKSKINPNLPKYVII
Protein: Potassium transporter 7 (AtHAK7) (AtPOT7) (Q9FY75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable potassium transporter.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Potassium channel SKOR
- Potassium channel AKT1
- Putative cysteine-rich receptor-like protein kinase 32
- K
- Potassium inward rectifier
- K
- Guanylyl cyclase 1
- CAX-interacting protein 4
Sequence:
MAEESSMEGSEKEEIDSSGGGFGDMASMDSIESRWVIQDDDDSEIGVDDDNDGFDGTGLESDEDEIPEHRLIRTGPRVDSFDVEALEVPGAPRNDYEDLTVGRKVLLAFQTLGVVFGDVGTSPLYTFSVMFSKSPVQEKEDVIGALSLVLYTLLLVPLIKYVLVVLWANDDGEGGTFALYSLISRHAKISLIPNQLRSDTRISSFRLKVPCPELERSLKLKEKLENSLILKKILLVLVLAGTSMVIADGVVTPAMSVMSAVGGLKVGVDVVEQDQVVMISVAFLVILFSLQKYGTSKMGLVVGPALLIWFCSLAGIGIYNLIKYDSSVYRAFNPVHIYYFFKRNSINAWYALGGCILCATGSEALFADLCYFSVRSVQLTFVCLVLPCLMLGYMGQAAYLMENHADASQAFFSSVPGSAFWPVLFIANIAALIASRTMTTATFSCIKQSTALGCFPRLKIIHTSRKFMGQIYIPVLNWFLLAVCLVVVCSISSIDEIGNAYGMAELGVMMTTTILVTLIMLLIWQINIVIVIAFLVVFLGVELVFFSSVIASVGDGSWIILVFAVIMFGIMYIWNYGSKLRYETEVEQKLSMDLMRELGCNLGTIRAPGIGLLYNELVKGVPAIFGHFLTTLPAIHSMVIFVCIKYVPVPVVPQNERFLFRRVCTKSYHLFRCIARYGYKDARKETHQAFEQLLIESLEKFIRREAQERSLESDGNDDSDSEEDFPGSRVVIGPNGSMYSMGVPLLSEYRDLNKPIMEMNTSSDHTNHHPFDTSSDSSVSEAEQSLERELSFIHKAKESGVVYLLGHGDIRARKDSWFIKKLVINYFYTFLRKNCRRGIANLSVPQSHLMQVGMTYMV
Protein: Actin-depolymerizing factor 2, isoform c (Uncoordinated protein 60) (Q07749)
Organism: Caenorhabditis elegans
Function: Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle.
Interaction partners:
- Actin
- Actin-interacting protein 1
- Profilin-1
- Profilin-2
- Profilin-3
- Ras-like GTP-binding protein rhoA
- Gelsolin-like protein 1
- Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
- Twinfilin
- Actin-related protein 2
Sequence:
MASGVKVDPSCKNAYDLLHNKHQHSYIIFKIDKNDTAIVVEKVGEKNAPYAEFVEEMKKLVEDGKECRYAAVDVEVTVQRQGAEGTSTLNKVIFVQYCPDNAPVRRRMLYASSVRALKASLGLESLFQVQASEMSDLDEKSVKSDLMSNQRI
Protein: Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Solute carrier family 25 member 12) (Q8BH59)
Organism: Mus musculus (Mouse)
Function: Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (By similarity). Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:O75746}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O75746}.
Interaction partners:
Sequence:
MAVKVHTTKRGDPHELRNIFLQYASTEVDGEHYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYVEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDVMVTIRSHMLTPFVEENLVSAAGGGTSHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDIEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGTGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTKRDGSIPLPAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLQDLGLFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGRVGGINLLTAGALAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVVDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPSGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPSVAVAQPKAAAAAQ
Protein: HSP20-like chaperones superfamily protein (T7M13.24 protein) (Q9S732)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At2g27140
- Jacalin-related lectin 2
- MATH domain and coiled-coil domain-containing protein At3g58360
- Protein RESTRICTED TEV MOVEMENT 3
- Protein RESTRICTED TEV MOVEMENT 1
Sequence:
MAAIFKRPRPGGGRHPPPLAPTVSSFKPRAQWTNSGSSIFLYVNLPGFYRDQIEIKKDERTRTVQIQGQRPLSAQTKARFSEAYRVPDTCDMTKLSTSFSHGLLTIEFPAIVEANKQEKAVQDQEKIGQRSNQEKSGGPGPNGSTLGRKKALEEEKQVGTSQEKTTPTLNEEAPKTYKSVVEGKRAVPTGSQEKSEAKVKAREAIPSLGGRERAKEEKVVERKEAAHIVQQKIGDKLKEEEAKSTPTLGGSLKPKVQAKEEKVIERKKDDDISQLKTGQKVKEKEISRTPTIDARVESKEHAKVVEKKEDGEIGQKLEGGRINLGPKKEDKFTKPVVGDEARRIEKNVAQRNQAEPKLKTKEGDERIKLDVDDGVRNKQDENNEMVGDMVSEGEIQDRVEQKKIDEAGLAKDRGDLKDNAEVVEPETGPLLVKEGQKKSDMDPPLAVGGRGMGEEESRTYDIPLVNVGVAALVIMGFGAYVFVPLVKYFS
Protein: Cdc42-interacting protein 4, isoform C (Cdc42-interacting protein 4, isoform G) (M9NE16)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLALLASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIFNIFGSNKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSSSSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEITLYA
Protein: STI1 domain-containing protein (Q93616)
Organism: Caenorhabditis elegans
Interaction partners:
- Electron transfer flavoprotein subunit beta
- Transcription factor unc-37
- Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- medium-chain acyl-CoA dehydrogenase
- Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial
- Isobutyryl-CoA dehydrogenase, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Fatty acid synthase
Sequence:
MSLADHIDAIKKEMTSLSSQFNSNKSELERSKQDLSSMQLQMQQQMNDSVQQDLQKAHDTSKKLDNLARTFLALITDPSQQSQLLAEFESISKNGTPQMPVMTPPMMNAVAAMQPHMMMRNPMLNAMGGASPRVSGKGGAPQNGGMNGMSMMQHMQMQAFQAQMMQAQMFQQMPMMMPGMVPGMPPGMAGLPGMMPPNNMAAAMQHFNAFQQMAAAASVAVSTPSRNPSTSGAASRTRTPLTTSATNSPRPTTEPTIKEEEPQTMEHDVAAAVAATTATATIKQEENSTVAVA
Protein: ELL-associated factor 2 (Ehrlich S-II transcriptional activator factor) (Testosterone-regulated apoptosis inducer and tumor suppressor protein) (Q91ZD6)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity). Acts as a transcriptional transactivator of TCEA1 elongation activity.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q96CJ1}.
Interaction partners:
- RNA polymerase II elongation factor ELL
- AF4/FMR2 family member 4
- RNA polymerase II elongation factor ELL3
- RNA polymerase II elongation factor ELL2
- ELL-associated factor 1
- Btk-PH-domain binding protein translocated to, 1)
- Protein AF-9
- AF4/FMR2 family member 1
- Transcription elongation factor A protein 1
- Little elongation complex subunit 2
Sequence:
MSGPAGLAYLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASIDTSCEGNLEVGKGEQVTITLPNIEGSTPPVTVFKGSKRPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSRIQYRLEQQQQQMWNLPRTSNLVQHSPSEEKMSPTSLMDDIERELKAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDDDQFSPLGPRKYSSEHPSMSAGPQYRTSEADATCHRLQDHSTLLMSTLRSDLQLSESESDSED
Protein: Protein RTE1-HOMOLOG (Q9SD42)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Ethylene receptor 1
- Ethylene response sensor 1
- Ethylene response sensor 2
- Ethylene receptor 2
- Protein EIN4
- Protein REVERSION-TO-ETHYLENE SENSITIVITY1
- Probable lysophospholipase BODYGUARD 1
Sequence:
MGETATDSEHRMMIGLSDPMKIDPKRDRFPCCIVWTPLPFISWLVPFIGHVGICREDGVILDFAGPNFVCVDNFAFGAVSRYIQINKEMESSRSSSSGMFNGERRYEQEEDSHEKEPTWDDALRKSTQEYQHHSYNILTCNCHSFVANNLNRLSIKSGGWNVVNLATLVLFKGRWVNKTAIVKSLLPPLIVYTIGILLGGWTFIASCSILVVLLTGWFIIGTYCFKKLIQL
Protein: Sterile affecting ciliogenesis (Q9VN30)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDPENLEVGQNYEGSQEFDESSTSSISNKGPDDSQFKREAEKAICIMPPRPGTTMMNYQELYIPRNQLTDVYYPIQEAQRWLTLMDKMGKAHRFPLPTILPKVIQTRYVPKRHLPKDVEVDRRRRQYQKINLVNELAKAGLTDDVLQPTEEQYNVMSEFAFPHKFPLSYFDDSNFDINSPAAWFELGVVGDAHYPLPAKAYLPYNQSLLNCQWGMAAVTAHHEDSDLWTLLSLEDGCTYTVPKLQFMFMAEDPHKYIKRLQAAVHERHKGEQLMLMELIVDCVLHEDIESTVFYSFKPIESVLQAAKVSEQCKRRLRSEVNLVFERLMALYELEQFILKMPKEFPQFRNINLKEFLPRSFAVDVSGKERLELQALGITMQEKRYDYLKASLFYCVGGIEAMAGVAIECQYIETLSIFICSFSKPLALVDFLQAQEAHSDNVATFLKVYWPQQLTTVITVVLRALGKGWLDISLNTWTVYLMCKISRFILQVKFRMQESMEVLLETSLMNFSHFVCDPCLQFLELKSNYKWTNNYIDTEFPFQKPVFAMTLGISEDRKVFYSTDPDEFQPGLVEIFKKCLEKSSGVRCIDGSVMSFLKFAPNLYILTVELIEDRFLRENELLKNCYAKAVLPLRAYARLYERFIDFYLLNVNTYMQAYAQAHKPSSEVKRDILENKRLKEELREILPAFITIGPFYINVDTMKQFMIKKRIEVVRRIFEYYVDRMYETNEVLLDRCLEMFRRIAERPISIEHLYEIRDFAQTVPDLVDELKADIQVMWLEYDLLDSFFYNLSDHQFAMKWNVYAWPHQIMVRLSTLKDEQKVDIEDFLRLHASECQAFEERLESLNDEVQAYSLAFNTNRAQETSVDIKKTWALIKELEKVSQTLQFRQELFELEPLSVEFLESIIASFTPYKNLWYGCANFLKLEDATLGNPIAQLDLEDVWNNLMRLRDELNESMKIFHEKVEIMDVAKTFIAKIDDFVPVYNSIKDIRNENWMYIHWQELSAITGQEIKYSVAMNYQYLIRKGILDVLPEVHIISEKANNEAEEIRRAIEEEERRKQAELNAMLLRKQLRKCRRDIL
Protein: Aldehyde oxidase 1 (EC 1.2.3.1) (Azaheterocycle hydroxylase 1) (EC 1.17.3.-) (Q9Z0U5)
Organism: Rattus norvegicus (Rat)
Function: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. Is a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also catalyzes nitric oxide (NO) production; under anaerobic conditions, reduces nitrite to NO with NADH or aldehyde as electron donor, but under aerobic conditions, NADH is the preferred substrate. These reactions may be catalyzed by several isozymes. May play a role in adipogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17353002}.
Interaction partners:
- Nicotinamide N-methyltransferase
- Aldehyde dehydrogenase 1A1
- Cytochrome P450 3A1
- Cytochrome P450 1A2
- Amine oxidase [flavin-containing] A
- Amine oxidase [flavin-containing] B
- Retinaldehyde dehydrogenase 3
- Cytochrome P450 1A1
- Alpha-aminoadipic semialdehyde dehydrogenase
- Aldehyde dehydrogenase, mitochondrial
Sequence:
MDPPQLLFYVNGQKVVENNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPVNACLTPICSLYGTAVTTVEGIGNTRTRLHPVQERIAKCHSTQCGFCTPGMVMSMYALLRNHPEPSLDQLTDALGGNLCRCTGYRPIIDACKTFCRASGCCESKENGVCCLDQGINGSAEFQEGDETSPELFSEKEFQPLDPTQELIFPPELMRIAEKQPPKTRVFYSNRMTWISPVTLEELVEAKFKYPGAPIVMGYTSVGPEVKFKGVFHPIIISPDRIEELSIINQTGDGLTLGAGLSLDQVKDILTDVVQKLPEETTQTYRALLKHLRTLAGSQIRNMASLGGHIVSRHLDSDLNPLLAVGNCTLNLLSKDGKRQIPLSEQFLRKCPDSDLKPQEVLVSVNIPCSRKWEFVSAFRQAQRQQNALAIVNSGMRVLFREGGGVIKELSILYGGVGPTTIGAKNSCQKLIGRPWNEEMLDTACRLVLDEVTLAGSAPGGKVEFKRTLIISFLFKFYLEVLQGLKREDPGHYPSLTNNYESALEDLHSKHHWRTLTHQNVDSMQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDIITADHLQDATTFGTETLLATDKVHCVGQLVCAVIADSETRAKQAAKHVKVVYRDLEPLILTIEEAIQHKSFFESERKLECGNVDEAFKIADQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKHIQDIVAATLKLSVNKVMCHVRRVGGAFGGKVGKTSIMAAITAFAASKHGRAVRCTLERGEDMLITGGRHPYLGKYKVGFMRDGRIVALDVEHYCNGGSSLDESLWVIEMGLLKMDNAYKFPNLRCRGWACRTNLPSHTALRGFGFPQAGLVTEACVTEVAIRCGLSPEQVRTINMYKQIDNTHYKQEFSAKTLFECWRECMAKCSYSERKTAVGKFNAENSWKKRGMAVIPLKFPVGVGSVAMGQAAALVHIYLDGSALVSHGGIEMGQGVHTKMIQVVSRELKMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQGTWKDWAQTAFDQSVSLSAVGYFRGYESNINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSYSPQGILYSRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVRAARQERGISGPWKLTSPLTPEKIRMACEDKFTKMIPRDEPGSYVPWNIPV
Protein: Polybromo 1 (A0A8I6G5U9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRRLAFRGAGCALVKLKKLESMGSKRRRATSPSSSVSGDFDDGHHSVPTPGPSRKRRRLSSLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDINLLTADFQLLFNNAKAYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTMADGSSPGYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMTKSSLRISNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFHQLYDTVRSCRNNQGQLIAEPFFHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMMEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKDKRKELGPLPDDDDMASPKLKLSRKSGVSPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPSRPPLTFDIIRKNVESNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIRIRDELCKNGEILLSPALSYTTKHLHNDVEKEKKEKLPKEIEEDKLKREEEKREAEKSEDSSGTTGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPETFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDEEKSTDNSDDNRAEDSFNLEKEKEDVPVEMSNGEPGCHYFEQLRYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMSCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIIPQKEPSPLLEKKIQLLEAKFAELEGGDDDTEEMGEEDSEVIEPPSLPQLQTPLANELDLMPYTPPQSTPKSAKGSAKKESSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGVMNQGVTPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPTGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQAYNLENV