wanglab/gogpt-training-data huggingface dataset:
Protein: Cyclin-T1.2 (P34424)
Organism: Caenorhabditis elegans
Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).
Interaction partners:
- Probable cyclin-dependent kinase 9
- Cyclin-dependent kinase 12
- Transcription elongation factor SPT5
- Cyclin-H
- Transcription elongation factor SPT4
- Cyclin-dependent kinase 7
- OCEL domain-containing protein
- Cyclin-C
- Cell division cycle protein 73
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MSNSNKLIAEKNGSRYGRMIHPWLRKKQDMLADTPSRREGMTYEEELSKRQQGGVFIFDIAMQLTHGKGEHGLSGVAATLFNRFFNVHSLKRCDFRDVAAACVFLAGKNEDAPKKLKYVVTQLWQFKYPHNKQFQSEQHFLDQCNVVTLIEDVLLKTISFDINVDLPHQYVLKLMRDVEKGRNVYKDMVKTAYYMATDVLIITDWSVRYSCASIATACVNIAAFFHNINMDDIVPFELSDRWYRLEDQSMTREEVEAMTKEFLDIFSRNPQFHIGSLKKIDPLGKVKIVGMPPQVSSTVTPSGSSSNLKKIDLESYKGRPKPLSNSSDSPSTRPSFLPDVKNQKVVEQELMEQRMKEAAQQKIHRNGHRPSSSSHPLHHHSTSSSASNNSNHQNRSSSGLSAHQHQKPYNEDSRSAKRSMMYEETNSSKKPRIDYKMSFVASSSTTIATMHNDHFSQTTHQQNISTYARGVNEMMLNQVAPPPLMSVSAQPSTYQKMCMEYQRNPADSRHTMSSTQQISPPDEPSPPVSQILLPPPPPPPILPPRLDEMEEGELV
Protein: GH21896p (Q8T0M5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKTSTPHPRSIWILTGCWLLPLLGLALFPFPPVHTADVTMADAAHQEFARRLALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGLASSDPEQIAHSFHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMVMCYASMLTFEPQPVQFHVQHPFNYYIINKDSTILFAGRINKF
Protein: Molecular chaperone Hsp40/DnaJ family protein (Q0WN54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Heat shock protein DnaJ with tetratricopeptide repeat-containing protein
- Heat shock protein DnaJ with tetratricopeptide repeat-containing protein
- Heat shock 70 kDa protein 6, chloroplastic
- ARP protein
- Heat shock 70 kDa protein 7, chloroplastic
- Chaperone DnaJ-domain superfamily protein
- Peroxidase 18
- Heat shock 70 kDa protein 3
- Nuclease
- Heat shock protein 90-3
Sequence:
MAALASPSLIPSSLCFAAAADGPRSLSSNFSAFSDGGSNFRYHKSFLSLSSSSSSSTPYRNRRGRSLVVFATSGDYYATLGVSKSANNKEIKAAYRRLARQYHPDVNKEPGATEKFKEISAAYEVLSDEQKRALYDQYGEAGVKSTVGGASGPYTSNPFDLFETFFGASMGGFPGMDQADFGRTRRSRVTKGEDLRYDITLELSEAIFGSEKEFDLTHLETCEACAGTGAKAGSKMRICSTCGGRGQVMRTEQTPFGMFSQVSICPNCGGDGEVISENCRKCSGEGRVRIKKSIKVKIPPGVSAGSILRVAGEGDSGPRGGPPGDLYVYLDVEDVRGIERDGINLLSTLSISYLDAILGAVVKVKTVEGDTELQIPPGTQPGDVLVLAKKGVPKLNRPSIRGDHLFTVKVSVPNQISAGERELLEELASLKDTSSNRSRTRAKPQQPSTLSTAPSGSENKKDEVKEENEEPEQENYLWNNIKEFAGSVANGALKWLRDNL
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (Q54DM3)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA helicase
- DNA mismatch repair protein Mlh1
- DNA mismatch repair protein Msh6
- ATP-dependent DNA helicase
- DNA topoisomerase 3
- Probable serine/threonine-protein kinase atr1
- Double-strand break repair protein
- Replication protein A subunit
- RecQ-mediated genome instability protein 1
- ATP-dependent DNA helicase ku70
Sequence:
MDKSNYNQLLSDFLDVSKANENTNIQTNNTNGGCGNNNNTTFDDCDEINEKSTIASTGCKDIKNIFSGVVPKVTYLPPKITPISTPNVILNSPTHPTSPSNININTNTTNTNITNSKITTTFMNTATTTTTNSNIKNEIDEDDNGFDDSLITKRRPIRKNSSLHLNDDDGDDDIVDTNNIPPPPSSSKTTPTITPSLPTKKIPAIFHSPIVNKTTNNNNNYNNNNNNNTNSINSNIYNFVNKNSSDLVKTIKSDLYDLGIKKKNLKNQKKGSSDDEKQRISDELQEIKKSKKELIKLLENALNNNNNNNNNNNNNNNNNNNNNNNNNNSSNNYNNISNNYSNSNNVVYNSNSTNNINNNSNNSNNSNSTSPTFKSSTIVQPPKVTPNYTSDISLDDDNYYPNDIDEYTHHSTTTTTTTTSKTNNDNNNNYDNDIIDLDEYDGFSGFDSGYENGTDSAMFDDEDVVVNEQKPTNNHFSTNSFNNSNNNNNNVFSVANFNGDNSRFKGNFPWSQKIIDINRSMFGFHVFRENQREIINSTLEGNDTFVLMPTGGGKSLCYQIPALYQKGLTIVISPLISLINDQVEFLETLGYPAAALSSAVSSDAAIDVYKDIRSNSPKIRLLYLTPERVVKSDSLIEILANLDQKGLFSRIVIDEAHCVSQWGHDFRPDYKELSILRRKFPKVPILALTATATERVRNDVIYNLSMRNPVCFKQSFNRPNLIYQVLKKTKQVVDDMSKFIHSTYPDKSGIVYCISKYDCENVAKRLRELKISAAHYHAGLENDERAKVQANWQKGRIKVIVATIAFGMGINKADVRFVIHHSVPKSLEGYYQESGRAGRDGGISHCLLYFSWADKLRNDLLIQNSFTSGQGSSHNTRETRDSLNKMVNYCENETDCRRQLQLAYFGENFEKSGCKKTCDNCISTLETTRKDVTEESKNLVKTIKALGSDTSNLIIDIFKGSKGKKVLEKCAQSGITNLHGIGKNWQKHEIERILHQLLRDNILKETISQNPYGGTYSHLSVGSYADNLLRNQKNVTLSFRSTPAKKTVSAAKKKKSSKNNEDDEEEEDEVPTNFVIIQNKTTKTDANLVARLEKLRQDLALIENIQETYIFSRDTIDDILRVKPKTIKELKGLTGLPSQKIDRYGKSIIQAINDFLSDTPYSFDKSSFQKIPFNSTQTSSYFSKSSSNPPHVHTISDDSEFDTDTTNFVIDNDTVDENENFDFEIDDNDYLDQPQQQQSNKRKQSSTSVTSTKSSRVKK
Protein: Abcc8 protein (Q6PGE2)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
ADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGVLLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFVRADK
Protein: Testin-2 (CMB-23) [Cleaved into: Testin-1 (CMB-22)] (P15242)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted.
Interaction partners:
Sequence:
MIAVLFLAILCLEVDSTAPTPDPSLDVEWNEWRTKHGKTYNMNEERLKRAVWEKNFKMIELHNWEYLEGRHDFTMAMNAFGDLTNIEFVKMMTGFQRQKIKKTHIFQDHQFLYVPKRVDWRQLGYVTPVKNQGHCASSWAFSATGSLEGQMFRKTERLIPLSEQNLLDCMGSNVTHGCSGGFMQYAFQYVKDNGGLATEESYPYRGQGRECRYHAENSAANVRDFVQIPGSEEALMKAVAKVGPISVAVDASHGSFQFYGSGIYYEPQCKRVHLNHAVLVVGYGFEGEESDGNSFWLVKNSWGEEWGMKGYMKLAKDWSNHCGIATYSTYPIV
Protein: Branched-chain-amino-acid aminotransferase (BCAT) (EC 2.6.1.42) (A0R066)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to their efficiency as amino donor: Leu > Ile > Val.
Interaction partners:
- 2-isopropylmalate synthase
- Dihydroxy-acid dehydratase
- Dihydroxy-acid dehydratase
- Dihydroxy-acid dehydratase
- Transketolase, central region
- Cystathionine gamma-synthase
- L-threonine dehydratase
- Cystathionine gamma-synthase
- 3-methyl-2-oxobutanoate hydroxymethyltransferase
- Alanine aminotransferase
Sequence:
MNSGPLEFTVSANTNPATDAVRESILANPGFGKYYTDHMVSIDYTVDEGWHNAQVIPYGPIQLDPSAIVLHYGQEIFEGLKAYRWADGSIVSFRPEANAARLQSSARRLAIPELPEEVFIESLRQLIAVDEKWVPPAGGEESLYLRPFVIATEPGLGVRPSNEYRYLLIASPAGAYFKGGIKPVSVWLSHEYVRASPGGTGAAKFGGNYAASLLAQAQAAEMGCDQVVWLDAIERRYVEEMGGMNLFFVFGSGGSARLVTPELSGSLLPGITRDSLLQLATDAGFAVEERKIDVDEWQKKAGAGEITEVFACGTAAVITPVSHVKHHDGEFTIADGQPGEITMALRDTLTGIQRGTFADTHGWMARLN
Protein: Claudin-5 (Q9JKD6)
Organism: Rattus norvegicus (Rat)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space.
Subcellular location: Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Occludin
- Tight junction protein ZO-1
- Tight junction protein 2
- Endothelial cell-selective adhesion molecule
- SRY-box transcription factor 18
- Cadherin-5
- Junctional adhesion molecule A
- Tight junction protein 3
- Claudin-12
- Claudin-3
Sequence:
MGSAALEILGLVLCLVGWVGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYESVLALSAEVQAARALTVGAVLLALVALFVTLTGAQCTTCVAPGPVKARVALTGGALYALCGLLALVPLCWFANIVVREFYDPTVPVSQKYELGAALYIGWAASALLMCGGGLVCCGAWVCTGRPEFSFPVKYSAPRRTTANGDYDKKNYV
Protein: Akirin-2 (Fourteen-three-three beta interactant 1) (Fourteen-three-three beta interacting-protein 1) (Q25C79)
Organism: Rattus norvegicus (Rat)
Function: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6. Also involved in adaptive immunity by promoting B-cell activation. Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells. Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors. Also plays a role in facilitating interdigital tissue regression during limb development (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:18460465}. Cytoplasm {ECO:0000250|UniProtKB:B1AXD8}. Membrane {ECO:0000250|UniProtKB:B1AXD8}. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. {ECO:0000250|UniProtKB:B1AXD8}.
Interaction partners:
- NF-kappa-B inhibitor zeta
- DNA methyltransferase 1-associated protein 1
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-2
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-3
- LOC100125377 protein.
Sequence:
MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQTDPGCSSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS
Protein: Bone morphogenetic protein 15 (E9PTU9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Bone morphogenetic protein receptor type-2
- Serine/threonine-protein kinase receptor
- Muellerian-inhibiting factor
- Growth/differentiation factor 9
- Follistatin
- Factor in the germline alpha
- Follicle-stimulating hormone receptor
- NOBOX oogenesis homeobox
- Lutropin-choriogonadotropic hormone receptor
- Inhibin alpha chain
Sequence:
MALLTILRILLWGMVLFMEHKVQMAKVEWPSTTLLAENPTLPSSLDLAKEAPGKEMKQWPQGYPLRYMLKLYQRSADPHGHPRENRTIGAKMVRLIKPSASAMRLLRGPWHIQTLDFPLASNEVAYQLIRATVVYRHQLHLVHYHLSCHVEPWVPKCRTKHFPSKSGSAKPSSVSKAWREMNITHCIQQKLWNRKGRRVLRLRFMCQQQKGNETLELRWHGMTSLDVAFLLLYFNDTDESAQAKLLARGQEELTDRESPFLMRSVRQTCSIASDVPCPSQEQDRSVNNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYCKGICTGVLPYGLNSPNHAIIQSLVNELVNRSVPQLSCVPYKFLPMSILLIEANGSILYKEYEGMIAQSCTCR
Protein: Insulin-like growth factor-binding protein 1 (Q90YJ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MNRLLLNFFWVAAFSALLAAPGLRASPVVGQEPIRCAPCSPERLAECPAVDAGCEEVLREPGCGCCLACALKRGDPCGIYTAPCGSGLRCLPKPGEARPLHALTRGQAVCTESPEPNHSQSETAPDHPESHNGATAVNEGSSTVFVTGHGKPFDPRIITNKESMKAKVNAIRKKLVEQGPCHIELQTALDKITKSQQKLGDKLTRFYLPNCDKHGLYKIKQCESSLDGQRGKCWCVSSWNGKKIPGSSDLPADAECPEELNH
Protein: procollagen-proline 4-dioxygenase (EC 1.14.11.2) (Q68VC1)
Organism: Brugia malayi (Filarial nematode worm)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319}.
Interaction partners:
Sequence:
MMFQIILNVLLLIAVSADSFSSLASLKALIGAERDIPVMINAYVEKELEKLDYLKKFAQEIQKSNNKAIRDGEEAITHPINAFLLIKGMTTDWNKVIKIMRSNSADDFIRNVTYQRIVKRINYPTEVDLSGAAIGILRLQDTYEMNTKDIADGKILNSKMRTVALTAEDCFEIGRVAYSEHDYYHAILWMQEARERIQKETKPTANLESILDHLAFSLYKQGNLKRALLLTDELYRMNPDHPRAKGNVRWYEDLLEDEGIRRADMRRKVPPMNNPRDKSNLKDTYEALCRQEVPINTKAQSRLYCYYKMDRPYLRLAPFKVEIVHQNPLVVLFRDIVSDEEMRIIEMLAVPKLARATVHNVVTGNIETAFYRTSQSSWLGSTEHEVVKRINKRLDLATNLETETAEELQVQNYGIGGHYEPHYDCSRRENVFEKTKNGNRIATILIYMTEPEIGGGTVFIDLKTSVSCTKNAALFWYNLMRSGAVDMRSYHAACPVLTGTKWTANKWFHESGQEWRRPCGLNQLDQERYVGDLGAPEPKRHLNIRSEKARK
Protein: Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma) (EC 3.1.4.35) (P61249)
Organism: Mus musculus (Mouse)
Function: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Interaction partners:
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
- Guanylate kinase
- GMP synthase
- Hypoxanthine-guanine phosphoribosyltransferase
- Inosine triphosphate pyrophosphatase
- Adenine phosphoribosyltransferase
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Regulator of G-protein signaling 9
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Sequence:
MSDSPSLSPPAPSQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQFGII
Protein: Pipsqueak, isoform J (Pipsqueak, isoform K) (A4UZC9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00320}.
Interaction partners:
Sequence:
MQNGGLLGVPMGFLDFTPEPPAPSATPVTVTEHVDLSCNPSTDTRDLSNTTEPLDIDNHLAQQIHRLDQSPMHSISHHHTGDESNSNLVQHIKSEVIEAKHLAAQHHALSQAQQQHAHHQAHQQHQQHQQQQHQQQQQHLHAQQLLAQSQLQQQQQQQQQQQQHHQQQQQQAAAAAAAAGVHGQHGGHVTHADIGGATVMEIDPSQIKHEPGMIITPEIVNMMSSGHMDMYNSDTSEDSMMIANGSPHDQKEPHYTNLDQQHGLGGSVCGPGPGGAGGGGGMSGGAGSGSGEKGQFNGPKAWTQDDMNSALDALKNQNMSLTKASAIYGIPSTTLWQRAHRMGIETPKKEGGTKSWNEDALQNALEALRSGQISANKASKAFGIPSSTLYKIARREGIRLAAPFNAAPTTWTPEDLERALEAIRAGNTSVQKASAEFGIPTGTLYGRCKREGIELSRSNPTPWSEDAMNEALNSVRVGQMSINQAAIHYNLPYSSLYGRFKRGKYDVVANTSGVALLNTSGNTTGSIEIIEHSQENSLHMLQQQFPYSPSPHPPTPQHHSTPQHHSSAQQGPPTPQHMQQHVVHMQQQQQQQQQQSPHPGHHPQHMQQDVVTSSSQVVHSQQQQQLQQIYQHHGTPERS
Protein: Trehalose transporter 1 (Facilitated trehalose transporter Tret1-1) (DmTret1-1) (A1Z8N1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Low-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20035867, ECO:0000269|PubMed:34032568}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:20035867}. Vesicle {ECO:0000269|PubMed:34032568}. Note=Levels at the plasma membrane increase upon starvation (PubMed:34032568). Localizes to vesicles positive for Rab7, Rab10, Rab19 and Rab23; efficient localization to the cell surface from cytoplasmic storage vesicles is dependent on Rab10 while protein turnover may be regulated by Rab7 (PubMed:34032568). {ECO:0000269|PubMed:34032568}.
Interaction partners:
- Trehalose transporter 1-like protein
- Heat shock protein 68
Sequence:
MSGRDNRGAGGGGGGHQPLSNAMGKLKEKLTRVGDELGYHRVESNLSTSNTATSLDTILPEDPFLFPQVSPQRHPQNTVRTQRLLEDEPPLSFRPLLEDDDINEPPTQQQQRTPLRASGSLELTPLPPPPTSLEIREHRDRQQRGAQGDELQRSKQSLKGSRVSFERRDTGNSNTNSNKAAESSDEDSFEEKRTGFQQQKATSVDHKGILKDLKHILANDNRRQFQAKKHVSLDVKGTRFLQDLLKESSSEEEFHKTRREFQGRKHQSLDPRVTFKLDKVLQGSSTDSDEEGEDAEHKRLIHRPKDITKPVIIDLKDLESESDEDFLTSRQHFQQQRSISTDSRKSRRLYEMDEMDNKRGENIRHAVPFVRQITEDGKPKLEVYRPTTNPIYIWTQVLAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWVGGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAGSFMNWSMLAFLGAALPVPFLILMFLIPETPRWFVGRGLEERARKALKWLRGKEADVEPELKGLMRSQADADRQASRNTMLELLKLNNLKPLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGGFFYCKTYGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKTLEDIERKMMGRVRRMSSVANIKPLSFNM
Protein: FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) (Q3TQB2)
Organism: Mus musculus (Mouse)
Function: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q96CU9}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Distal membrane-arm assembly complex protein 2
- Transmembrane protein 70
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 beta subcomplex subunit 1
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- Distal membrane-arm assembly complex protein 1
- Complex I intermediate-associated protein 30, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase iron-sulfur protein 5
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
Sequence:
MFRRALRLGLGPGLPYRGLRTRKGGFTLDWDAKVSDFKKKVDSILPGKKYEVLYDTSHLPPEQADVVIIGGGILGLSVAFWLKKLESRRGAIRVLVVEQDHTYSRASSTGPSVGGIWQQFSVPENVQLSLFSINFLRNINEYLAVVDAPPVELQFNPSGCLLLASEKDAATLENNVKMQRQEGAKVCLMSPEQLQTKFPWINVEGVALASYGLEDEGWFDAWSLLQGLRRKVQSMGVFFCQGEVTRFITSSTPMKTPTGEHVVLRRINNVHVKMDKSLEYQPVECAVVINAAGAWSGKIAELAGVGKGLPGTLQGTKLPVEPRKRYVHLWHCPQGPGLETPLVADISGVYFRREGLGSNYLGGCSPTEEEEPDPTNLNVDHDFFQNKVWPHLVQRVPSFKTLEVQSAWAGYYDYNTFDQNGVVGPHPLVVNMYFATGFSGRGLQHAPGIGRAVAEIMLEGHFKTIDMSPFLFTRFYLGEKLQEYNIL
Protein: Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (B0BL87)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRGAALLLLALGLQQAEGRCVFNRTQEYCLCYRLTQESAGSVIQCLAASAVEFQGGDLEKYADFPIEDLDDSTIDMLGSLQIRKIIFSDLLVPEVLLARVLRFFSYTQVQEMVFKSCSFVGRSSWADMAGRALPIVSLRFHNVTAAALAGREQDLSPLSRWLGALQELSVTASRLAVLPCAVGQALRALRSLDLARNSLGDDSLAPAFCQGAFTQLRVLSLRHNNLTSYSGVCGSVRLLGELQHLDLSHNALTAGTPSSPCQWPATLRIFNLSSAGLDHVLAPLPPALEVLDLSSNRLHAVDISLRSLQALFLSRNALPAAPSIRGCPALHTLHLDNNLIAELPRDEALLLEHLQDVAVAGNPFNCTCGGAGAVQALAAVGCLRQGWPQGYVCHAPARYQGVLLRDVPTSVLQCNPAAVLAPVCTGLALLCVAMAGGLLWARGARPRWLCGLGQREDACSGAEHL
Protein: Basic helix-loop-helix transcription factor scleraxis (P59101)
Organism: Gallus gallus (Chicken)
Function: Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- BRICHOS domain-containing protein.
- Mohawk homeobox.
- Semaphorin-3D
Sequence:
MSFAMLRPAAGRYLYPEISMLSEDEENGSESSGSDEKPFHLDADGFGIKAGKRRSGKKAGRLHREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYISHLGNVLLVGEACGDGQPCHTSPAFFHHGGGGGSPPPRDSENSQPKQICTFCLSNQRKLSKDRDRKTAIRS
Protein: Sec-independent protein translocase protein TatB (Q9HUB4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00237}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00237}.
Interaction partners:
- Sec-independent protein translocase protein TatA
- Sec-independent protein translocase protein TatC
- GMP synthase
- Sec translocon accessory complex subunit YajC
- Protein-export protein SecB
- Secretion protein MttC
- Protein translocase subunit SecA
- Protein-export membrane protein SecG
- Phosphoribosyl-ATP pyrophosphatase
- Ribosomal RNA small subunit methyltransferase E
Sequence:
MFGISFSELLLVGLVALLVLGPERLPGAARTAGLWIGRLKRSFNTIKQEVEREIGADEIRRQLHNEHILSMEREAQKLLAPLTGQNPPQETPPPAAESPAPSVPTPPPTSTPAVPPADAAAPPAVAASTPPSPPSETPRNP
Protein: ADP-ribosylation factor 1-like 2 (EC 3.6.5.2) (ADP-ribosylation factor-related protein 1) (Q10943)
Organism: Caenorhabditis elegans
Function: Small GTPase involved in protein trafficking between different compartments (By similarity). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. Plays a role in maintaining mitochondrial morphology.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:P84077}; Lipid-anchor {ECO:0000250|UniProtKB:P84077}; Cytoplasmic side {ECO:0000305}. Note=In the GDP-bound form, associates transiently with the membranes via its myristoylated N-terminus where guanine nucleotide-exchange factor (GEF)-mediated nucleotide exchange occurs (By similarity). Following nucleotide exchange, the GTP-bound form undergoes a conformational change, leading to the exposure of a myristoylated N-terminal amphipathic helix that provides stable membrane anchorage (By similarity). {ECO:0000250|UniProtKB:P84080}.
Interaction partners:
- Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog
- Probable coatomer subunit gamma
- Coatomer subunit epsilon
- Probable coatomer subunit delta
- Coatomer subunit beta
- AP-1 complex subunit gamma
- Rho-GAP domain-containing protein
- Probable coatomer subunit zeta
- Uncharacterized protein F07F6.4
- ADP-ribosylation factor GTPase-activating protein 1
Sequence:
MGNVFGSLFKGLFGKREMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVGEAREELMRMLAEDELRDAVLLVFANKQDLPQAMNAAEVTDKLGLHSLRNRSWYIQATCATSGDGLYEGLDWLSNQLKNRS
Protein: RAN binding protein 1 (C9JXG8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGAIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKGSGKNDHAEKVAEKLEALSVKEETKED