wanglab/gogpt-training-data huggingface dataset:
Protein: Complement C3 (HSE-MSF) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] (P01027)
Organism: Mus musculus (Mouse)
Function: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
Subcellular location: Secreted.
Interaction partners:
- Integrin alpha-M
- Complement factor B
- Complement factor H
- Complement receptor type 2
- C3a anaphylatoxin chemotactic receptor
- Complement factor I
- Properdin
- Complement factor D
- C5a anaphylatoxin chemotactic receptor 2
- Complement C2
Sequence:
MGPASGSQLLVLLLLLASSPLALGIPMYSIITPNVLRLESEETIVLEAHDAQGDIPVTVTVQDFLKRQVLTSEKTVLTGASGHLRSVSIKIPASKEFNSDKEGHKYVTVVANFGETVVEKAVMVSFQSGYLFIQTDKTIYTPGSTVLYRIFTVDNNLLPVGKTVVILIETPDGIPVKRDILSSNNQHGILPLSWNIPELVNMGQWKIRAFYEHAPKQIFSAEFEVKEYVLPSFEVRVEPTETFYYIDDPNGLEVSIIAKFLYGKNVDGTAFVIFGVQDGDKKISLAHSLTRVVIEDGVGDAVLTRKVLMEGVRPSNADALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKTPKFFKPAMPFDLMVFVTNPDGSPASKVLVVTQGSNAKALTQDDGVAKLSINTPNSRQPLTITVRTKKDTLPESRQATKTMEAHPYSTMHNSNNYLHLSVSRMELKPGDNLNVNFHLRTDPGHEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVLSLPITPEFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCIGTLVVKGDPRDNHLAPGQQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKNYAGVFMDAGLAFKTSQGLQTEQRADLECTKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPMRYSCQRRARLITQGENCIKAFIDCCNHITKLREQHRRDHVLGLARSELEEDIIPEEDIISRSHFPQSWLWTIEELKEPEKNGISTKVMNIFLKDSITTWEILAVSLSDKKGICVADPYEIRVMQDFFIDLRLPYSVVRNEQVEIRAVLFNYREQEELKVRVELLHNPAFCSMATAKNRYFQTIKIPPKSSVAVPYVIVPLKIGQQEVEVKAAVFNHFISDGVKKTLKVVPEGMRINKTVAIHTLDPEKLGQGGVQKVDVPAADLSDQVPDTDSETRIILQGSPVVQMAEDAVDGERLKHLIVTPAGCGEQNMIGMTPTVIAVHYLDQTEQWEKFGIEKRQEALELIKKGYTQQLAFKQPSSAYAAFNNRPPSTWLTAYVVKVFSLAANLIAIDSHVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNAKEADVSLTAFVLIALQEARDICEGQVNSLPGSINKAGEYIEASYMNLQRPYTVAIAGYALALMNKLEEPYLGKFLNTAKDRNRWEEPDQQLYNVEATSYALLALLLLKDFDSVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQTDVPDHKDLNMDVSFHLPSRSSATTFRLLWENGNLLRSEETKQNEAFSLTAKGKGRGTLSVVAVYHAKLKSKVTCKKFDLRVSIRPAPETAKKPEEAKNTMFLEICTKYLGDVDATMSILDISMMTGFAPDTKDLELLASGVDRYISKYEMNKAFSNKNTLIIYLEKISHTEEDCLTFKVHQYFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHSEMCRCAEENCFMQQSQEKINLNVRLDKACEPGVDYVYKTELTNIELLDDFDEYTMTIQQVIKSGSDEVQAGQQRKFISHIKCRNALKLQKGKKYLMWGLSSDLWGEKPNTSYIIGKDTWVEHWPEAEECQDQKYQKQCEELGAFTESMVVYGCPN
Protein: Stac-like, isoform Q (A0A0B4LF79)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MGISAHAAPASFWNHPRRIRRTPTSDRDGVDQCRPWICRRKDRRPAHPAANRPPESRVCGPSSTFRWDDWAAPAPRTRERATDCARMCMCTSRIPYSVARICARTTSMHSSRPASRSSSFIRRPLTRRQRMAVGGVTRRLWRTMRVYTIHQGRGVRRARAAQAVAAYLRDRRARIGKGWPAQGHGVRISATEQWADKPVVRRPGDPTRRVAAGAVPVLAERLPKVTGSSVKSSSGRRSRRRRIFGWRGPRGGSLSPQGGSMASYNGVLKDYSHSSLNEAFKSQNNVNFKLIKTVSDFSETLSRLYEEHATALQVAVSNYRKKNAELRKERPACHLAIFQAWETFLQEVETDSQACNDVASVLSRQVSRPMLDKSFHRKVQSRKIFTHRESFETIIAKTEEKLSKCRVDYKQCHLAHRQNPSQHSLTEYIDAHNAYVQQLHATNGMLEAYHTDTLPQQMQELEEIHNDLVAIVSDSLMQGAEVIAGKANDQAKRYNSLSNQCAAVSPQQDLVNFVRLLAQPSQAQKIPRRLFASPQAEVGEEAGDHNEMTPCLRNELVFDRHSTLSQRSALESLKREAIELELQIRQLQDSIEALNRTQTRGIEGQLYNKVNELQEDLSMKKFDLRAKQIHLAAIRAQKDLFVSKVEPTSPRNERKFSAATAPSMKTKWLKAFKSLKPAGSGSAQQADRRNGASSTASEPLRPNLDGSHHLQEYTYKKITACDVCSQILRGHTRQGLRCRICKLNAHGDCAPNLPRCQPKQKLLRRQKSTSELENRVDIEEETSPQESLVAAAADQADDPSPNLNMNTNTNTITNPSANQLNVPNAKFRQKTPFMHRIAQLAGADKSVQAKQMDGSVAGGSALPVPVLSERELGRAPPPDIPIVSVSELALQEQQQQQQQQQQQHQQQQRSLASVAQAAAVRAGRGVRPPPVAMPILGVQLQQQELQQQRGGLPVPSQDISSSSASANPKSETTRPFGEPLMLLKSTESNPDESKGNRRVR
Protein: NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, 10, 42kDa, isoform CRA_c (NADH:ubiquinone oxidoreductase subunit A10) (NDUFA10 protein) (Q8N1B9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALRLLKLAATSASARVVAAGAQRVRGIHSSVQCKLRYGMWHFLLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGKPLATDYNGNCSLEKFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIRKQCESALQTHFWVCGATLQGL
Protein: Iodothyronine deiodinase (A9JRP6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MGSAVGFALRKLFVYISAVLMVCAAILQMSMLKLLSFISPGRMRKIHMKMGERSTMTQNPKFRYEDWGPAFFSLAFIKTLFFVNWCSLGLEAFEGHAAPDSALITLDRQKTSVHRFLKGNRPLVLSFGSCTUPPFLYKLDEFKQLVKDFSNVADFLIVYLAEAHATDAWAFKNNVDISVHKNLEERLAAARTLLKEDPPCPVVVDEMNNITASKYGALPERLYVIQSGKVIYQGGIGPWGYKPEEVRKVLEKSK
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (EC 2.7.11.26) (EC 2.7.11.31) (Acetyl-CoA carboxylase kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (Tau-protein kinase PRKAA1) (Q2PUH1)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- 5'-AMP-activated protein kinase subunit beta-1
- 5'-AMP-activated protein kinase beta-2 non-catalytic subunit transcript variant 2
- 5'-AMP-activated protein kinase subunit gamma-1
- Protein kinase AMP-activated non-catalytic subunit gamma 2
- Uncharacterized protein.
- Uncharacterized protein.
- Serine/threonine-protein kinase STK11
- TSC complex subunit 2.
- Acetyl-CoA carboxylase
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
Sequence:
MRRLSCWFKMAAADKQKHEHGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPTDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIRDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECTEEEVLSCLYSRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLSRPHPERVPFLVAEAPRPRHTLDELNPQKSKHQGVRRAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSAYSKMSLQLYQVDSRTYLLDFRSIDDEIIETKSGTATPQRSGSVSNYRSCQKDSDGDAQGKSADTSLTSSMTSSLDSSTADLTPRPGSHTIEFFEMCANLIKILAQ
Protein: GH28809p (Mnt, isoform A) (Mnt, isoform C) (Mnt, isoform E) (Q8SY46)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSGIGGIGVLLEAAQFLEQHEKLPQAGGGGGSALGVGVALPQQQQQTVHCKSNSIINNNNSSQHNRNSSSSSNGIIATPPFTNGNGNGTVGVGNASAIFNVSVNANGNGLSNGHSSPRSQLAAAATAHDYEYSAAGVANGHSEGRPHVSAARDQQDHPQHQQHANHMQIQQHYGYMRSNIGGVIYGLHKDSADSAASSACGAGAGAAAVGMSIASSAPAAGSQLSAHHHTGHGGRRRTTSSNSNGAGTREVHNKLEKERRAQLKECYDLLKKVLPMGDEDRKKTSNLTILDTAHKYVNSLSHEVCEQEAKIEKLAKQKIELQKRLKQLSLRRESPPTDQQIIPQADKAVCLATTATTAPPTAASGHNGTTILFDAGNACATGQLTTVINKTNGGATAAASSKHNGNHTGGATTTLTPAMGIMTIKNGNGSNGNMLAISPTGGHNHQLHQHHNGSPAGSPSGIGATTGATITRGSPTPSTPSPSPSSSSSGVSLSTSFMGGSSSSSSSSSSSSSSSSSSSSSSPTQQQQIITPTATARSVGLKFHGGAGAAVPAGGGSVNGFHQADKDRNYTFLRLSAGTTAQ
Protein: Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (P12656)
Organism: Mus musculus (Mouse)
Function: Indispensable for the control of thyroid structure and metabolism.
Subcellular location: Secreted.
Interaction partners:
- Glycoprotein hormones alpha chain
- Thyrotropin receptor
- Follicle-stimulating hormone receptor
- Prolactin
- Lutropin-choriogonadotropic hormone receptor
- Pituitary-specific positive transcription factor 1
- Pro-thyrotropin-releasing hormone
- Prolactin-6A1
- Pro-opiomelanocortin
- Thyrotropin-releasing hormone receptor
Sequence:
MSAAVLLSVLFALACGQAASFCIPTEYTMYVDRRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPHHVTPYFSFPVAVSCKCGKCNTDNSDCIHEAVRTNYCTKPQSFYLGGFSV
Protein: Paired box protein Pax-3-B (xPax3-B) (Paired-domain transcription factor Pax3-B) (Q0IH87)
Organism: Xenopus laevis (African clawed frog)
Function: Probable transcription factor. Promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. Acts downstream of msx1 to induce the neural crest, cooperating with zic1 and mediating signals from both the wnt and fgf8 signaling pathways. Induction of hatching gland cell fate is independent of zic1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P23760, ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00381}.
Interaction partners:
Sequence:
MTSLAGAVPRMMRPCPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKVTTPEVEKKIEEFKRDNPGMFSWEIRDKLLKDGVCDRNTVPSVSSISRILRSKFGKGDEEDMELDRKEQEESEKRAKHSIDGILRERAPASPESEEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGAFPPTAMPALPTYQLSETSYQPTSIPQAVSDPSNTVHRPQPLPPSSVHQSLPSNPDSSSAYCLPSSRHGFSSYTDSFVPPSGPSNPMNPAIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLEPPTAVSASCSQRLEHMKSLDSLSTSQSYCPPTYSTSGYSMEPMTGYQYPQYGQSAFHYLKPDIA
Protein: Cytochrome b5 (Q8IRR0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004131}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004131}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004131}. Microsome membrane {ECO:0000256|ARBA:ARBA00037877}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037877}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037877}.
Interaction partners:
- NADH-cytochrome b5 reductase
- FAD-binding FR-type domain-containing protein
- Sulfite oxidase, mitochondrial
- FI02892p
- FI21247p1
- NADPH--cytochrome P450 reductase
Sequence:
MSKEIRLATVNEHNKATDLWVVIDNKVYDVTKFRLEHPGGEESLVDEAGRDATKAFNDVGHSSEAREMLKKYYIGDLAAADIKKKSPISCRHVALALGAAFIGISLVYVIRRGVARN
Protein: DNA-binding transcriptional repressor TubR (Q8KNP2)
Organism: Bacillus thuringiensis subsp. israelensis
Function: A DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid. Cooperatively binds to the centromere-like site (tubC), which may seed filament formation by the TubZ polymerizing GTPase, stabilizing TubZ filaments. TubR-tubC complexes track the depolymerizing minus end of the filament, probably pulling plasmid within the cell. Required for plasmid replication. Negatively regulates levels of TubZ; its effect on RNA expression has not been shown (Probable). Specifically binds iterons, 12-bp imperfect direct repeats that function as a plasmid origin of replication. Four TubR dimers bind to tubC, forming an extended bent DNA-protein filament with protein wrapping helically around the outside of the DNA.
Interaction partners:
Sequence:
MNRDHFYTLNIAEIAERIGNDDCAYQVLMAFINENGEAQMLNKTAVAEMIQLSKPTVFATVNSFYCAGYIDETRVGRSKIYTLSDLGVEIVECFKQKAMEMRNL
Protein: DNA-directed RNA polymerase I subunit RPA2 homolog (EC 2.7.7.6) (Q27493)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000269|PubMed:34365510}. Nucleus, nucleolus {ECO:0000269|PubMed:34365510}. Note=In 1- to 8-cell embryos, in which rDNA is not actively transcribed, protein is evenly distributed in the nucleus without significant nucleolar enrichment. {ECO:0000269|PubMed:34365510}.
Interaction partners:
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase subunit
- Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- CHCH domain-containing protein
- Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3
- RNA polymerase I-specific transcription initiation factor tif-1A
Sequence:
MDCDIASYHVDSFDFLVSKGCQFAAQAVPAEKFRLKNGDAVTMKFTSAQLHKPTLDTGAKLTSDTLPLLPAECRQRGLTYAGNLKVGIDVHVNGSRLDIIEIILGKVPIMLRSEGCHLRGMSRKELVVAGEEPIEKGGYFIVNGSEKVIRLLIANRRNFPIAIIRKTFKEKGKLFSEFGVMMRSVKENHTAVMMTLHYLDTGTMQLALQFRREIFYVPLMYIVKALTDKNDAVISAGFKRGRNQDQFYSSCILNMLAQCQEEEILNQEAAIRAIGSRFRVAVSDRVAPWEDDLEAGRFIIRECVLIHLDSDEEKFHTLAYMTQKLIALVKGECAPETPDNPQFQEASVSGHILLLILRERMENIIGMVRRKLEYMSSRKDFILTSAAILKALGNHTGGEITRGMAYFLATGNLVTRVGLALQQESGFSVIAERINQLRFVSHFRAIHRGAFFMEMRTTDVRKLRPEAWGFICPVHTPDGAPCGLLNHVTASCRIVTDLSDNSNVPSLLAELGMYTHKTVALAPPGEELYPVLMNGRFLGYVPITKAASIERYLRCAKVAKDARIPYTSEIALVRRSTDIKNIQTQYPGIYILSDAGRLIRPVRNLAMDAVEHIGTFEQVYLSVVLDPEEAEPGVTMHQELHPSCLFSFAGNLIPFPDHNQSPRNVYQCQMGKQTMGTAVHAWHSRADNKMYRLQFPQQPMLKLEAYEKYEMDEYPLGTNACVAVISYTGYDMEDAMTINKASYQRGFAHGTVIKVERINLVTERERKTIFYRNPREEIKTVGPDGLPIPGRRYFLDEVYYVTFNMETGDFRTHKFHYAEPAYCGLVRIVEQGEGDSGAKHALIQWRIERNPIIGDKFASRHGQKGINSFLWPVESLPFSETGMVPDIIFNPHGFPSRMTIGMMIESMAGKAAATHGENYDASPFVFNEDNTAINHFGELLTKAGYNYYGNETFYSGVDGRQMEMQIFFGIVYYQRLRHMIADKFQVRATGPIDPITHQPVKGRKKGGGIRFGEMERDAIIAHGTSFVLQDRLLNCSDRDVAYACRRCGSLLSVLMSSRAGSHLLKKKRKDDEPLDYTETQRCRTCDKDDQVFLLQVPRVFRYLTAELAAMNVKIKLGIEHPSKVTGS
Protein: 5-demethoxyubiquinone hydroxylase, mitochondrial (DMQ hydroxylase) (EC 1.14.99.60) (NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase) (EC 1.14.13.253) (Ubiquinone biosynthesis monooxygenase COQ7) (O74826)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:18808426, ECO:0000269|PubMed:24911838}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03194}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03194}.
Interaction partners:
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Ubiquinone biosynthesis protein coq9
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- Ubiquinone biosynthesis protein coq4, mitochondrial
- Atypical kinase COQ8, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Ubiquinone biosynthesis protein coq11
- Thiol-specific monooxygenase
- Uncharacterized methyltransferase C1347.09
Sequence:
MLSRRQLIPIATKSVSPFLRSSITCRRISMGRKELSEKDSNILDSVIRVDQAGELGANQIYKGQHFILQFTDPKVAPTIQHMWDQEKYHLATFDNYVLKNRVRPTFLRPFWDIAGFALGAGTALLGTKAAMACTEAVETVIGGHYNDQLRETAHLENKAPEFKEIRSHLAEFRDDELEHLNTAVEGWNAKEAPAHALLTNAIQMGCKAAIWMCKRF
Protein: GM04379p (Q8MQK7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTGAKKRSGAPLVDAAHSKAPKPGTVAQEKNSQIPTVWKKDHVKTQLFERSNEKPSKKRTPLVAPRVQQSKIEAQTSQAVEKTQEDQTFAATIDSSTKSLKKSPKNEGELWADIQKLSPHTGVIIHSFIKQYNDSLNNLKKKDLVVSKKMRAIAMDSLKKKSENISLKEKLTNMELELTQLKTDLIEQQEKNAENIQKYTEINKKYTHCEQHYDKELEIIKVCVEKKNSELRDAQSRMALQAQELNNMQQTNRELAGACENYKKDLEEAEVAKSMILHELTDLKELHEDLQLQFEDVSAQKEKFEANILQLSSDLNAKMLDCAQLEDRIEQLPIEANKALSKLQRDLEASELQFVDQQRLTDQATRELELVRNEINTFKTLIEEKERRHVSLSDELTQMTERLSELADINESYLNELTETKLKHSQEIKDQADAYEIVVQELKESLNKASVDFTQLKSNSEKLHKETLLQVSELQEKLIEMVSHRSNQEELIKRLGNEIQEKTHNFEEELKRQQEQLANQMQTKATEVESENKRNAVEIQKLKSELEERNKAFKAQQDKLEYLISDHDTLKSAIINLQAEKKEIESELSTAKVKFSEELQSQKDNLMKKVSELELEIKRKETELIELEREKNNEMAVLQFKMNRINCLIDQPVTTIKQLKDSKGPTRTESIPTKVQPENTDEFSSTARKRNARRQKITTYSSDFDSGDDIPIVGNSLSGKRAKLCAPIKPQNNIDMFDMLKNSK
Protein: Transmembrane protein 14A (Q9Y6G1)
Organism: Homo sapiens (Human)
Function: Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:21723035}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21723035}.
Interaction partners:
Sequence:
MDLIGFGYAALVTFGSIFGYKRRGGVPSLIAGLFVGCLAGYGAYRVSNDKRDVKVSLFTAFFLATIMGVRFKRSKKIMPAGLVAGLSLMMILRLVLLLL
Protein: UNC-76 (Q7JL61)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MEAADLRVPDIPLASCDDDDIDSNKNLSNHSSDEKHHCNSNSDEERLHDEFSGSLEDLVGNFDEKIAACLKDHEVTTADIAPVQIRTQEEVMNESQTWWTLTGNFGNIQPLDFGTSSICKKMAAALDSDSLKDDASTRRSMTNSDDEDLLRQQMDVHQMIGHHHGSTDTGGETPPQTADQVIEEIDEMLQSCDFTGSMMTDRTMESVDSMYSSMRSPFPSSIQSSDADIKLRSAQALVSNPDNLQELSYSKLVTLCAEMEQLIRVYNESLVDELAHRDELDYEKEMKNSFISLLLAIQNKRRVYANDRKRKVGKASDASQLPQYLTATIPYNDHQHIDNASIASLIKSEKMKRDINKYLIDKEYQLCVD
Protein: Transcription factor dcp-66 (Deacetylase complex protein dcp-66) (G5ED89)
Organism: Caenorhabditis elegans
Function: Transcription factor which binds to the 5'-CCATACATTA-3' motif found in the promoter region of pgp-12 and activates its expression in the excretory cell.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable histone-binding protein lin-53
- Protein let-418
- DIOX_N domain-containing protein
- Chromodomain-helicase-DNA-binding protein 3 homolog
- Probable histone-binding protein rba-1
- Histone deacetylase 1
- Methyl-CpG binding protein 2/3 C-terminal domain-containing protein
- Egg-laying defective protein 27
- Histone deacetylase
- Nucleus
Sequence:
MAQVQQVPSSPMNGIPEKNGNGLSIEESASTAVAALAHIQNGAVLFHGTPTKDLNGASTSIDTDDLQLSPSDLRRRSTRASALKAQEKIKLKDDIVQGPQKRANDDDDMEDEELGDEINEQSAPKKRRLENGKEFDQTCFRFGLRANNEGEVYAMTDESENSSIHESEMEVVRYHYEKMKNKEPDEEQLRERLNMRREAENQLREEEAKLLVLRKMKDSQTRAITKLAAETKAADLAEATSAAYKPAVATNGKSVTNGKNSMIESNNKTMNGLKNLSIPQQLELLQKLSSQSPAAKQAYIMAKKNPAQTTQLFQQLITINNQNLQKQKELSAAETNASASASPAVQQSQQAQQPQQAQITQSKLLNQQTPAQRIQAARLAFRAQADKQLTTIPTQKSQPHDITFLPNPNASAFLALHGLDLVVQHVLKDRSNETPYAGPSYECEECKTECAHTWKAIGSTQDDLHLYCENCVRSAQKRKNRTDQTALLKRAFQKITAQEKLLQEFEKKIAEGQLEQYAEAKAAAPATSQTIPTSSTATVSSIPLVPRLPQIPSSTGSSTPTQAVKTSTPIHSTPKSSSSSAKKTAAQLQQQSMQGMNQLFSTAMLRNNPQMQQMLQMYQALAMGGGAANMANNQMAMLFQAQAMQAAQAQVARAQAAKAQAAQAQAAQAQAQAQANREANQQSMLIQALMSNGQVNVQALQQLQKLTPEQQKALIEVVKRQTRK
Protein: Regulator of G-protein signaling egl-10 (F5GUD0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MALPRLRVNASNEERLVHPNHMVYRKMEMLVNQMLDAEAGVPIKTVKSFLSKVPSVFTGQDLIGWIMKNLEMTDLSDALHLAHLIASHGYLFQIDDHVLTVKNDGTFYRFQTPYFWPSNCWDPENTDYAVYLCKRTMQNKAHLELEDFEAENLAKLQKMFSRKWEFVFMQAEAQYKVDKKRDRQERQILDSQERAFWDVHRPVPGCVNTTEVDFRKLSRSGRPKYSSGGHAALAASTSGIGCTQYSQSVAAAHASLPSTSNGSATSPRKNDQEPSTSSGGESPSTSSAAAGTATTSAPSTSTPPVTTITATINAGSFRNNYYTRPGLRRCTQVQDTLKLEIVQLNSRLSKNVLRTSKVVENYLAYYEQRRVFDPLLTPPGSQADPFQSQPNPWINDTVDFWQHDKITGDIQTRRLKLWEDSFEELLADSLGRETLQKFLDKEYSGENLRFWWEVQKLRKCSSRMVPVMVTEIYNEFIDTNAATSPVNVDCKVMEVTEDNLKNPNRWSFDEAADHIYCLMKNDSYQRFLRSEIYKDLVLQSRKKVNQKGPKGFLTGNLPSFSNAVRTNLHVGQQGSSCSPTSNAPP
Protein: Bifunctional (p)ppGpp synthase/hydrolase RelA [Includes: GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTP 3'-pyrophosphotransferase) (Stringent response-like protein) (ppGpp synthase II); Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)] (P9WHG9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp, which is then hydrolyzed to form ppGpp, as well as the hydrolysis of ppGpp. RelA is probably a key factor in the pathogenesis of M.tuberculosis as it regulates the intracellular concentrations of (p)ppGpp.
Interaction partners:
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein bS6
- Exopolyphosphatase 2
- Exopolyphosphatase 1
- Large ribosomal subunit protein uL6
- Guanylate kinase
- Large ribosomal subunit protein uL2
- Pyruvate kinase
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein bL27
Sequence:
MTAQRSTTNPVLEPLVAVHREIYPKADLSILQRAYEVADQRHASQLRQSGDPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYTLEALTEEFGEEVGHLVDGVTKLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNTLTASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGVRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVLHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALETGKDAMAREVRRGGLPLQRLVNGESMAAVARELHYADVSALYTAIGEGHVSAKHVVQRLLAELGGIDQAEEELAERSTPATMPRRPRSTDDVGVSVPGAPGVLTKLAKCCTPVPGDVIMGFVTRGGGVSVHRTDCTNAASLQQQAERIIEVLWAPSPSSVFLVAIQVEALDRHRLLSDVTRALADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNAVRNVEGVYDVYRVTSAA
Protein: ATP synthase subunit beta (EC 7.1.2.2) (A0A1D8PKZ9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Uncharacterized protein
- ATP synthase subunit a
- ATP synthase subunit 9, mitochondrial
- ATP synthase subunit 4
- ATP synthase subunit alpha
- ATP synthase subunit gamma
- ATP synthase subunit 5
- ATP synthase subunit delta, mitochondrial
- F1F0 ATP synthase subunit g
- ATP synthase subunit d
Sequence:
MVLPRLFNASSRAAFRAVKRDVLFNSRTLATAAAAHGKVRAVIGAVVDVQFDEGNLPAILNALTLKNGDQDLVLEVAQHLGENTVRAIAMDGTEGLVRGTEVNDTGAPISVPVGRGTLGRIINVVGEPIDDRGPIECKEKKPIHAEPPSFVEQSTAAEILETGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGFSVFTGVGERTREGNDLYREMKETGVINLEGDSKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKKGSVTSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKSRLLDASVVGQEHYDVATGVQQTLQAYKSLQDIIAILGMDELSEADKLTVERARKIQRFLSQPFAVAEVFTGIPGRLVRLQDTVKSFKDVLEGKYDNLPENAFYMVGGIEDVVAKAEKLAAESN
Protein: PsbQ-like protein 3, chloroplastic (Q2V4B2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Note=Associated with the chloroplast NAD(P)H dehydrogenase/photosystem I (NDH/PSI) supercomplex. {ECO:0000250}.
Interaction partners:
- Photosynthetic NDH subunit of lumenal location 2, chloroplastic
- Photosynthetic NDH subunit of lumenal location 3, chloroplastic
- Photosynthetic NDH subunit of lumenal location 1, chloroplastic
- PsbP-like protein 1, chloroplastic
- Photosystem I reaction center subunit IV B, chloroplastic
- PsbP domain-containing protein 7, chloroplastic
- Peptidyl-prolyl cis-trans isomerase FKBP17-1, chloroplastic
- Peptidyl-prolyl cis-trans isomerase FKBP17-3, chloroplastic
- Protein NDH-DEPENDENT CYCLIC ELECTRON FLOW 5
- Photosystem I chlorophyll a/b-binding protein 5, chloroplastic
Sequence:
MAISKPPPLHFTFFHNQDSSIDTSDSNLALSIDTSRRRRDVLLTISGTLIPQLFFFDRKRSSSANAADFFNFGAPPPEPERTVELAQEGLRKNAENIKRIKEIMIEKKLWKEGGKELRRSASNMKQDFYLIIQAKPPKDRPLFRSLYSSLFNSITKMDYAARDGDETKVLEYYINIVAILDDIFPRI
Protein: inosine/xanthosine triphosphatase (EC 3.6.1.73) (Q583F1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial
- Electron transfer protein, putative
- Acyl carrier protein
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase, mitochondrial, putative
- Reiske iron-sulfur protein, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
Sequence:
MIIWAVGTTNKAKLNSVALVVNKCFPDQQHDIRPVEVSSAVRAQPMSAGESQEGAQHRAREALRHIPDAHYGVGMEGGLEKIGDRWFECGWMHVIERSSGREGTGSSGRFEMSQKLMQKILNEGKELAEIMDEMTGEKDVRSGQGAMGVLTAGHLNRAESYTHGLIYALAPFLSSRTYWDN
Protein: tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (Q38A72)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR038170}.
Interaction partners:
- tRNA
- tRNA
- Uncharacterized protein
- Putative tRNA
- NLE domain-containing protein
- Putative rRNA methyltransferase
- rRNA methyltransferase, putative
- ATP-dependent DEAD/H RNA helicase, putative
- Ribosome production factor 2 homolog
Sequence:
MMGDAGSFCKRGPEDFKVGVPDNAVRSEGRITLGDYVMITGGGMKRIVHVQAGGKLRLGSSGSVQLDKLAGVRFGEVVYYDPRSRVFVPTNDYPDLDITTLEEHIEDGRDNRHLVDENKSQVLSNEEIAEMRREKGVDVFLNTLVEKSATFHAKTAYSQEKYLRKKKKRYGVLYKIERVTPDGVAETYLPTINPTDVEPESRVLRLRADTLALILHHSDVHSGSRVIVYDKTNGHLEAALLTRLGSDGIIFQIMDRTAQPNMFPSQTMGIENVRELWKAVPRNAAFLRGEEDTENEEKATEKVNKRGKEGGSEVSQWLRGIDARRMLQERPADSLIIVDDEDDAPAALDDLLPFVALNGHIVVHSPFLEDLTALFTKLRGECVNICISEVWCRHHQVLPNRTHPTVRMSTASGYLLTAIKVNESTINCSGAGAPQSPIEEVTPSVPAEVPAVDGRLSRKHPRAQENGEQEGNLSDS