wanglab/gogpt-training-data huggingface dataset:
Protein: Nephrocystin-3 (Q6AZT7)
Organism: Xenopus laevis (African clawed frog)
Function: Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
Subcellular location: Cell projection, cilium {ECO:0000250}.
Interaction partners:
Sequence:
MGTASSLVNAGEVIEDTYGGGGGEDCVIPVEVKPKARLLRSSFRRGPRVIGASFKSTASVDLEYAAEYERLKKEYEIFRVSKNNEVASMQKKEIKLDEENKRLRAELQALQKTYQKILREKESAVEAKYQAMERAATFEHDRDKVKRQFKIFRETKEKEIQDLLRAKRDLEAKLQRLQAQGIQVFDPGESDSDDNGTEVTVPSTQCEYWTSGALGSDPSMGSMMQLQQSFRGPEFAHSSIDVEGPFANVNRDDWDAAVASLLQVTPLFSQSLWSNTVRCYLMSTAETQAEVEIFLRDYSPKLQRMCETSGYFFQMVFFPEECESQHFAVRKWEIEKSSIVILFICSSLPSCLQEDCEEAFLKNNEAKPRLIYHSIEDGRSDSDGLKQLLEQDTNKANKTKVVDHCGDPVEGAYKLYCHLEQVIKQDLLGIEISDPDAKDESATMEDDDYGDVLWDVHDEQEQMEAYQQASQSICELGFQKYYDRLNDLVAAPAPIPPLLISGGPGSGKSLLLSKWIQLQQKHSPNTLMLYHFVGRPLSSSSEPSLIIKRLTLKLMQHSWSVSSLSMDPGKFLEEFPHWLEKLSIRYQGNIIIIIDSIDHIQQSEKHMKWLIDPLPVNVRVIVSVNVETCPQAWRLWPTLHLDPLNSKDVKALINMECGGANILLTKEQERKLERHCRSATTCNALYVTLITKLLTWAGSTGKIEDVLQQCLQCQDTVSLYRLVLRSVQEVMPSAKEKEFMREILCFISVSHNGVSECELMELCPGLTWEVLTSLIYHLYTLVLLKYTCGLLQFQHLQAWDAVNLEYMQGGQNIISEYREKIIKHFTTQLSHDRVTWRSADELTWLFQQQGEKQKLHKCLMNLFVSQNLYKRGHFAELLSYWQLVGKDKISMASEYFDALKQYEKNCEGEEKMTSLADLYETLGRFLKDLGLLSQAVTPLQRSLEIRETALDPDHPSVAQSLHQLAGVYMQSKKFGNAEQLYKQALEISENAYGSEHLRVARELDALAVLYQKQNKFEQAEQLRKKSLKIRQKSARRKGSMYGFALLRRRALQLEELTLGKDTSDNARTLNELGVLYYLQNNLETAETFLKRSLEMRERVLGADHPDCAQSINNLAALYNEKKQYDKAEELYERALDIRRRALSPDHPSLAYTVKHLAVLYKRKGKLDKAVPLYELAVDIRQKSFGPKHPSVATALVNLAVLYCQMKKQDDALPLYERAMKIYEDSLGRMHPRVGETLKNLAVLRYEEGDYEKAAELYKRAMEIKETETSVLGAKAPSGHSSSGGDTYSVQNTLPVSVFPE
Protein: Transferrin receptor 1b (Q32PQ5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MAGTIGQAKMKFSRMVNSRSYSRFNQSQNPDGDGSRVEVKLAVDGEEEEMDGTELGNMQQETYTRSTGRSEPLNKYRILVCVGAALLVFLVGLLIGYSVHRKSDNKSEPLETPCSKEIQAEEPDPPQYEPIVPSIDWSDIVKLLNDKLSSKSIEEQLSVYSQIGRSAGSSVDNKLGDTIHDAFTKLNMEPWVDEHYVKLQNPDSSNPNKVWFGNEEIGSPKGFLAYSETGRREGRVVYANYGEPADLQAVQANEVSLNGTVVLMRAGRISMAQKVMNVAKLGAVAALIYPDPANYDGMDTELYGHVHLGSGDPYTPGFPSFNHTQFAPAKSSGLPEILAQTIPASMARKILSKMGGSEVPSKFKGGFTSYKFGDESNKVALSINNKLVDTKIHNVFGVIKGYVDPDRYVVIGAQRDSMTSGYAKSAVGTTLLMELARVFNELKKEGFKPKRSIVFASWTAGDFGKVGATEWLEGYWASLDRKAFTYISLDGVVSGKDSLRASASPLLHTLLQKTLEKVKAPMLSYGSDFSSILTNMQMDDGAYPFLTFSGIPSVSFSFISSRTTPDYKYFGTEMDTKERLDSVTGQQVVELSMLAAQVAGQMALRLVHDQILRLDVTKYGGVIESHVKNIIHHVNVLKSEKVEKIETLSTEWLIAAKSSCSRAATKLNNDIKNSDLEDMEMCRIINNRIMKVEHNFLSPYVSIRDFPFRHIFFGNGWQTATDLENYLQDVRDKKASFDIDQVLNKFALLTWSIQGCANDLAGDIWSLDNEI
Protein: Interferon 1EA (Interferon epsilon) (R9XMN7)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MINKHCFEIVLVLLASSTIFSLELKLAFFQQRVNRESLKLLNRFQKSSIQQCLAHRKNFLLPQQSVNRHQYQKGQALAILHEMLQQIFNLFRANISLEGWEERHMENFLTELHQQLEYLEVLMSLEAEPNSGILRSDNPRLQIKRYFQRIHNYLENQEHSSCAWTIIRGEINQCLFFAFQLIRNLSK
Protein: Protein hook homolog (DdHk3) (Q54IK9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Cytoskeletal linker protein involved in tethering membrane bound organelles to the cytoskeleton.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
Sequence:
MIETSFIKWINSFKDLSNSIEDLKELSNGTIFNEICCQIAPKYFDIDSLRKDGLDNWIFREENIKNIVERVDEFYIEEMGLNDQISSINCEEIANENIDEIILLIEAILGMAMESENNEAVIENILSLDQDTQNDLMVVVAKIQQSHQPNTVDNSKSFDKDGSILSQSPSQSNNSISNNNNNNNIDSSNISKSNISSNNNNNNSSNNNKEEILNLQNEIEKLKREKQEIQNDLDESNIQLSNVTMDRDRITIDKQKTEEVCSSLHESIIGLQKQLDETMAQTTTMNALNDETYKTEINDLHMQVESKEKQLSELKKKVDEANRLANENRSLRDEIDILREKAANAEATEEKLKKHQKKIEEIGDLKKKIKELEDQNDSYIQQTLDLEEQLSKNNTYRTQADSGKQQISSLKIELAKLELSLKSIKEDRDKLSESLNTVELERDSLQSQVTNLRNTIDNQQQEYETKFVDLQSSISLNSGGSGGLGDEVIDGSTKERIARLERDNKRLKEVAEKASELENQLEDANQSKELLTIQIKQLEEQKQQSNNTNNNNNNNNMVDSSEIESLKQQLKEKEKEISTLKRKLEESNLSLDENRKQLVELSQRPTTQSPGDIEKLENYENLLKENDGLEGRLRAARNIIKDLREKHKSYSNQETQLATKDEVITKLEGLVKKKTDINEDLRKQLEEGREESQREINLMLSAFLKIGLEMEQVKIQNISSSKEPRSFLNKKRAD
Protein: Prolactin-inducible protein homolog (14 kDa submandibular gland protein) (SMGP) (Gross cystic disease fluid protein 15) (GCDFP-15) (Prolactin-induced protein) (P02816)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Zinc-alpha-2-glycoprotein
- BPI fold-containing family A member 2
- Proline rich, lacrimal 1
Sequence:
MQGLSFTFSAVTLFLVLCLQLGIIESQDDENVRKPLLIEIDVPSTAQENQEITVQVTVETQYRECMVIKAYLVSNEPMEGAFNYVQTRCLCNDHPIRFFWDIIITRTVTFATVIDIVREKNICPNDMAVVPITANRYYTYNTVRMN
Protein: Transcription factor TCP10 (O82277)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164). Participates in ovule develpment.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00701, ECO:0000269|PubMed:11158442}.
Interaction partners:
- Transcription factor TCP14
- Transcription factor TCP15
- Transcription factor TCP23
- Transcription factor TCP21
- Transcription factor TCP20
- Transcription factor TCP19
- Protein SPEAR3
- Transcription factor TCP8
- Transcription factor TCP16
- Transcription factor TCP22
Sequence:
MGLKGYSVGEGGGEIVEVQGGHIIRATGRKDRHSKVFTSKGPRDRRVRLSAHTAIQFYDVQDRLGYDRPSKAVDWLIKKAKTAIDKLELGETTTTTTRQEPVNTKPESPTLVFQRENNDQTQFVAANLDPEDAMKTFFPATTTTNGGGGTNINFQNYPHQDDNNMVSRTTTPPPNLSQDLGLSLHPFQGNNNTVVVPETNNFTTTHFDTFGRISGWNHHDLTMTSSSSSEHQQQEQEERSNGGFMVNHHPHHHHHQPSMMTLLNSQQQQVFLGGQQQQQQRGTLQSSLFPHSFRSWDHHQTTSDHHHHQNQASSMFASSSQYGSHGMMMMQGLSFPNTTRLLHGEEATQPNSSSSPPNSHL
Protein: Gre2p (A0A1D8PHQ6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Glyoxalase 3
- Lactoylglutathione lyase
- Amine oxidase
- Amine oxidase
- L-serine ammonia-lyase
- L-serine ammonia-lyase
- Threonine dehydratase
- Tryptophan synthase
- enoyl-[acyl-carrier-protein] reductase
- Small ribosomal subunit protein uS19
Sequence:
MSGETVFVTGATGYIAQHIIKQLLSKGYSVIGSVRSQSKGEQLKELITAHHQDTTGDAKFDYVIVESLIEPGAFDSILQNHKEVGVFIHSASPIPFATDNVEKDILQPAIDGTKNVLTSIKKYGNENIKKLVITSSIAAVEPLGTGQTEPKTISEKDWNPITFEQGLANPAVAYYASKTLAEREVWKFVDENKNQLNFDVAVINPSFVFGPQAFGIKDKSAALRSTGEIINSVLKLKSNDPIPSLVASFIDVRDVARAHIIAFEDDDAIGQRLILDNEIFTKELIAHLIKKNFPSLDIPEGDIVKSEEEIANYPWRVDSTKTEKILGFKYISLDKSVVDTVNQLI
Protein: Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) (Q91XA2)
Organism: Mus musculus (Mouse)
Function: Unknown. Cellular response protein to viral infection.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q8NBJ4}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8NBJ4}. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption. {ECO:0000250|UniProtKB:Q8NBJ4}.
Interaction partners:
Sequence:
MMGLGNGRRSMKSPPLILAALVACVIVLGFNYWIASSRSVELQTRIVELEGRVRRAAAERGAVELKKNEFQGELQKQREQLDRIQSSHSFQLENVNKLHQDEKAVLVNNITTGEKLIRDLQDQLKALQRSYSSLQQDIFQFQKNQTSLEKKFSYDLNQCISQMTEVKEQCDERIEEVIRKRNEAPGSRDLAETNNQHQQALKPQPKLQEEVPSEEQMPQEKGDVPRNKSQIPAPNSESLGLKPQVQNEETNEIQAVGEEHQQASIQGQAVADGTRVGAEKLDQHTQLPAGLLARPEEDSQYPEREQLVIRDRQEQQRASEEGGGQKNPGDEYDMDENEAESEREKQAALAGNDRNINVLNADAQKRGIINVPVGSERQSHILNQVGIHIPQQA
Protein: Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) (Q9DCD5)
Organism: Mus musculus (Mouse)
Function: Plays a role in regulating the structure of the Golgi apparatus.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:11602598, ECO:0000269|PubMed:22841714}. Cell junction, tight junction {ECO:0000269|PubMed:11602598}. Cell membrane {ECO:0000269|PubMed:22841714}; Peripheral membrane protein {ECO:0000305}. Note=Recruited to tight junctions (TJ) during late stages of maturation of the TJ complexes. Excluded from adherens junctions and desmosomes. {ECO:0000269|PubMed:11602598}.
Interaction partners:
- Disks large homolog 3
- Tight junction protein 1
- Disks large homolog 2
Sequence:
MSSAAPAKKPYRKAPPEHRELRLEIPVSRLEQEESLTDAERMKLLQQENEELRKRLASATRRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHALASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDARNTINKLEELNERYRLDCNLAVQLLKCNKSHFRNHKLADLPCELQDMVRKHLRSGQEVASPSPSPSSSLSPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSGGDPASPPAPGSPNGECCSVSTAGGSPEEELPLPAFDKLSPYPTPSPPHPLYPGRKVIEFSEDKIRIPRNSPLPNCTYATRQAISLSLVEDGSERAHRSSVPSSPASAQGSPHHQPSPAPSALSAPASSASSEEDLLASWQRAFVDRTPPPAAVVQRTAFGRDSLPELQLHFSPGHSTAPPPSPHRERGLVLPAEPDSGFPQDEEEEMLNLPVSPEEERQSLLPDKEGTEEASGPSHVDGRAWPLPSPSRPQRSPKRMGVHHLHRKDSLTQAQEQGTVLS
Protein: Centromere protein X (CENP-X) (P0DJH7)
Organism: Gallus gallus (Chicken)
Function: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (By similarity). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:19620631}. Chromosome, centromere {ECO:0000269|PubMed:19620631}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19620631}. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS. {ECO:0000250|UniProtKB:A8MT69}.
Interaction partners:
- Centromere protein S
- Centromere protein W
- Centromere protein T
- Fanconi anemia group M protein
- Fanconi anemia core complex associated protein 24
- Fanconi_A_N domain-containing protein.
- Uncharacterized protein.
- Fanconi anemia group F protein
- Fanconi anemia group C protein homolog
- E3 ubiquitin-protein ligase FANCL
Sequence:
MEEREGGFRKETVERLLRLHFRDGRTRVNGDALLLMAELLKVFVREAAARAARQAQAEDLEKVDIEHVEKVLPQLLLDFV
Protein: PEP-dependent dihydroxyacetone kinase 2, phosphoryl donor subunit DhaM (EC 2.7.1.121) (PTS system EIIA component) (Phosphotransferase enzyme IIA component) (Q92ET9)
Organism: Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Function: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:22773791}.
Interaction partners:
- PTS-dependent dihydroxyacetone kinase 2, dihydroxyacetone-binding subunit DhaK
- PEP-dependent dihydroxyacetone kinase 2, ADP-binding subunit DhaL
- PEP-dependent dihydroxyacetone kinase 1, ADP-binding subunit DhaL
- PTS-dependent dihydroxyacetone kinase 1, dihydroxyacetone-binding subunit DhaK
- NAD-dependent glycerol dehydrogenase
- PEP-dependent dihydroxyacetone kinase 1, phosphoryl donor subunit DhaM
- Glycerol-3-phosphate dehydrogenase
- Glycerol-3-phosphate dehydrogenase [NAD
- HTH-type transcriptional regulator GolR
- Triosephosphate isomerase 2
Sequence:
MISIVLVSHSQKITEGLQEMIVEMVGDTVHIISSGGTGDGRLGTNALMIADNIATCTNSEHIYIFCDIGSAILSAETALELLDTELLEKTTIIDAPLVEGAFTAAVQSLVNPSKEAILQELTNVH
Protein: Rho GTPase Rac, putative (Q4WWL5)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- Rho GTPase activator Rga, putative
- Rho GDP-dissociation inhibitor
- Rho GTPase activator
- SH3 and Ded_cyto domain protein, putative
- Rho guanyl nucleotide exchange factor, putative
- Actin associated protein Wsp1, putative
- Ras GTPase activating protein, putative
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase ste20
- Protein kinase C
Sequence:
MASGPATQSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYTASVMVDGRPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPPSFDNVKAKWYPEIEHHAPNVPIILVGTKLDLRDDPATAESLRQRKMEPVSYEQALAVAKEIRAHKYLECSALTQRNLKSVFDEAIRAVLNPRPAAKPKSKKCTIL
Protein: D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2 (D-2HG--pyruvate transhydrogenase DLD2) (EC 1.1.99.40) (Actin-interacting protein 2) (D-lactate dehydrogenase [cytochrome] 2, mitochondrial) (EC 1.1.2.4) (D-lactate ferricytochrome C oxidoreductase) (D-LCR) (P46681)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the reversible oxidation of (R)-2-hydroxyglutarate to 2-oxoglutarate coupled to reduction of pyruvate to (R)-lactate. Can also use oxaloacetate as electron acceptor instead of pyruvate producing (R)-malate. In addition to its enzymatic role it could play an important role in the yeast cell morphology.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:10509019}.
Interaction partners:
- L-lactate dehydrogenase
- Hydroxyacylglutathione hydrolase, mitochondrial
- Hydroxyacylglutathione hydrolase, cytoplasmic isozyme
- D-lactate dehydrogenase [cytochrome] 1, mitochondrial
- NAD-dependent malic enzyme, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
- Probable glutathione-independent glyoxalase SNO4
- Glutathione-independent glyoxalase HSP31
- Probable glutathione-independent glyoxalase HSP33
Sequence:
MLRNILVRSTGSNFKFAGRYMKSSALLGYYRRVNYYSTKIQTRLTSENYPDVHRDPRFKKLTSDDLNYFKSILSEQEILRASESEDLSFYNEDWMRKYKGQSKLVLRPKSVEKVSLILNYCNDEKIAVVPQGGNTGLVGGSVPIFDELILSLANLNKIRDFDPVSGILKCDAGVILENANNYVMEQNYMFPLDLGAKGSCHVGGVVATNAGGLRLLRYGSLHGSVLGLEVVMPNGQIVNSMHSMRKDNTGYDLKQLFIGSEGTIGIITGVSILTVPKPKAFNVSYLSVESFEDVQKVFVRARQELSEILSAFEFMDAKSQVLAKSQLKDAAFPLEDEHPFYILIETSGSNKDHDDSKLETFLENVMEEGIVTDGVVAQDETELQNLWKWREMIPEASQANGGVYKYDVSLPLKDLYSLVEATNARLSEAELVGDSPKPVVGAIGYGHVGDGNLHLNVAVREYNKNIEKTLEPFVYEFVSSKHGSVSAEHGLGFQKKNYIGYSKSPEEVKMMKDLKVHYDPNGILNPYKYI
Protein: Prespore protein Dp87 (Q04503)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Spore wall. Note=Stored in prespore vacuoles until it is discharged into the interspace of spores during spore formation.
Interaction partners:
- Prestalk protein
- Uncharacterized protein DDB_G0272420
Sequence:
MRILYLASLLFLITLYLSPTFGWGGGRDCESHRSEYTCKSDRSCAYLPFVSCCGKKEFFCVNRDHRNCCDDLSCAKNTRTGEIFEIWSSCKPHRDFVPYHSPNTTTCESLGCEARGMECEWVESSPCYGTSCCPRIPRCVGHHGGGHKCDRMRCPEGFYCEEQGGSACCVPHHDGCGNIQCPWGHYCVNEHGKCRCVPHRPPPRPPVDQCRNQHCPHGYSCRVIKGCATCVRDARPPHNLCRGFGCPEGSHCEVLEKHPVCVRNHVPPHPPPPPQICGSVNCGPGYICTIINGHPTCIRGDGYLCNQTRCPHDYQCETISTNIVKCSPKNDECKWHRCPPGSSCFNSRNGPHCLANNVFPQLCKVTQCPTDFSCKMIRGNPTCIKARPPVPPPHCSTCAELSSACNHVGMICIQVPSNCTNTRFPCCPSHPICIHPSTTAASTIATTASTVATTTSATTAGTTTGGTTTGGSTSDSSAASSADSSAASSSPSSSAASSAASSEPSSSAASSSAPSSASSSAPSSASSSAPSSSASSSAASSAASSESSESSSATS
Protein: Transmembrane protein (F4JV40)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Histone-lysine N-methyltransferase SETD1B-like protein
- Probable sugar phosphate/phosphate translocator At2g25520
- Serine/threonine-protein kinase PCRK2
- Thioredoxin H1
- Major facilitator superfamily protein
- demerged
- Protein GET1
- ATPase GET3A
- Lysine-specific histone demethylase 1 homolog 2
Sequence:
MASNSREARRRKILDRGSDRLAFITGQINGVPSPPPSDSTSSLSQSDLQTDQSLPDTIPPRDQILKAQEIAFTSHQDNISDAAMLENVDHIIHQSREEPLQPQRHAETLAEASASDPRDTTTIQPPPTTSSVQNPSVVDLGASQAFIPVVSFVNAITPKHIGAAIDASEYARMFTALAIALVVILSHLGFSSLGNIVSFRPVFLLVLTDATIVLGRVLLSHRGDSSSASGTVMSGQGIVDQVGNALETVMMVKKIMDALLMDFSLYAVILICGLLVTQSIFP
Protein: Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) (Q99K24)
Organism: Mus musculus (Mouse)
Function: Acts as a zinc-influx transporter.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15634741}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19458277}; Multi-pass membrane protein {ECO:0000255}. Note=Localized primarily at the cell surface but also found in a perinuclear compartment in HC11 cells (PubMed:15634741). In mammary epithelial cell, localized primary to the apical membrane (PubMed:19458277). {ECO:0000269|PubMed:15634741, ECO:0000269|PubMed:19458277}.
Interaction partners:
- Zinc transporter ZIP4
- Zinc transporter ZIP11
- Zinc transporter SLC39A7
- MutS protein homolog 4
- Zinc transporter ZIP9
- Proton-coupled zinc antiporter SLC30A1
Sequence:
MTKLLVAKVLCMVGVFFFMLLGSLLPVKVIEADLEKAHRSKKVLSLCNTFGGGVFLATCFNALLPAVRDKLQQVLSLGHISTDYPLAETLMMVGFFLTVFVEQLVLTFRRERPPFIDLETFNAGSDAGSDSEYESPFVGVGNRSHSLYPEPTAHTHGAGLRLRELGRPGPLRLLSLVFALSAHSVFEGLALGLQEEGERVVSLFVGVAIHETLVAVALGISMARSAVPLRDAAKLAVTVSAMIPVGIGLGLGIESARSVASSVASALLQGLAGGTFLFVTFLEILAKELEERSEQLLKVLFLVLGYAVLAGMVFLKW
Protein: Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4) (Q54DT8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P51175}.
Interaction partners:
- Ferrochelatase, mitochondrial
- Oxygen-dependent coproporphyrinogen-III oxidase
- Uroporphyrinogen decarboxylase
- Endonuclease V
- Delta-aminolevulinic acid dehydratase
- Porphobilinogen deaminase
- UDP-glucose 4-epimerase
- Acetyl-CoA hydrolase
Sequence:
MIQKVGIIGSGISGLSSYYYLRNGINLTSKFSKNNLKINIFEKSNKVGGNIQTRIIQGKNKDEKIIVEEGPRSLRALGRGLNTLEFIKRLGISNDIIFSSANSNGKFVLLDGKPKEIPMTSLFDIIKFSFKHSIVSSILKEPFKKVPSQVKEMDPNWDESVHDFFSRRLGKTMTKTFIEPTILGIYGGDYTNLSIKSTFKRAALLEPFGGLILGSLFKSKKQKQFELDLDKNEKRLLPSKNELTELFDKDTDKTNVFSFKENGLSRMIQKLKSLIESDSLTKLYLSTSIVEIEKDVTNGTLKVTDNKGNQYQYDQLISTIPLNQLAPMFKKSDSKLYQLLQSVNYTSIAVINLIYKSNKNVVKIISDKGFGYLVPSKENQSVIGVCFDSNTFPEFVNNNNNNNNDNDNGNEKDQSIITVMIGGNNGIKDRNDNWIDVTNTSKDKLLDIALKHLDKVLDIESSPDFTNVSIYDNGIPHYNIGHQNLINEIQNHITKNYGTTLLLGGNSIDGVGINDSIHKSKQLINSLKLSNN
Protein: Aspartate-beta-hydroxylase (A0A8I5ZX27)
Organism: Rattus norvegicus (Rat)
Subcellular location: Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004157}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004157}.
Interaction partners:
Sequence:
MAPRKNAKGGGGNSSSSGSGSGSGSPSTGSSGSSSSPGARREAKHGGHKNGRRGGISGGSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLAKAKDFRYNLSEVLQGKLGVYDADGDGDFDVDDAKVLLGLTKDGSNENIDSLEEVLTILAEESSDWFYGFLSFLYDIMTPFEMLEEEEEEETADGVDGTSQKEGVQGKTCVILDLHNQ
Protein: LHFPL tetraspan subfamily member 5 protein (Lipoma HMGIC fusion partner-like 5 protein) (Tetraspan membrane protein of hair cell stereocilia) (Q8TAF8)
Organism: Homo sapiens (Human)
Function: In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q4KL25}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient localization to the plasma membrane requires the presence of PCDH15. {ECO:0000250|UniProtKB:Q4KL25}.
Interaction partners:
- Transmembrane channel-like protein 1
- Transmembrane inner ear expressed protein
- Transmembrane channel-like protein 2
- Protocadherin-15
- Calcium and integrin-binding family member 2
- Collagen alpha-2
- Glutathione hydrolase 7
- Harmonin
- Cadherin-23
- Unconventional myosin-VIIa
Sequence:
MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVNTPQAGYFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALGMFLIIGSIICFSLFFICNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFMLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGTEEV
Protein: Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP) (P16036)
Organism: Rattus norvegicus (Rat)
Function: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:2250020}; Multi-pass membrane protein {ECO:0000269|PubMed:2250020}.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- ATP synthase F
- E3 ubiquitin-protein ligase RING1
- ATP synthase F
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Chromobox 1
- Uncharacterized protein
- BMI1 proto-oncogene, polycomb ring finger.
- Non-selective voltage-gated ion channel VDAC2
Sequence:
MFSSVAHLARANPFNAPHLQLVHDVSGPRSPPGPPRRSRHLAAAAVEGYSCEFGSMKYYALCGFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGIFNGFSITLKEDGVRGLAKGWAPTLIGYSMQGLCKFGFYEVFKALYSNILGEENTYLWRTSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLREAVPKMYKEEGLNAFYKGVAPVWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECTKAEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSTASQVLQRLGFRGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGLTE