wanglab/gogpt-training-data huggingface dataset:
Protein: Protein unc-13 homolog C (Munc13-3) (Q8NB66)
Organism: Homo sapiens (Human)
Function: May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to presynaptic structures. {ECO:0000250}.
Interaction partners:
- Regulating synaptic membrane exocytosis protein 2
- Protein unc-13 homolog A
- Protein unc-13 homolog B
Sequence:
MVANFFKSLILPYIHKLCKGMFTKKLGNTNKNKEYRQQKKDQDFPTAGQTKSPKFSYTFKSTVKKIAKCSSTHNLSTEEDEASKEFSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQELSSIESSYSESLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGALRKLRKWKKSQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTHDVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRRETRDIHDYIKHLGHMGSKASLRFLNVTEERFEYVESVVYQILIDKMGFSDAPNAIKIEFAQRIGHQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKGIPSSQTYESMAIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTSKPSSKSHSARSKNKTANSSRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSDFFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDSPKDQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEWNQGADLGLDSSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWHSRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQSTANESSTTLDSDVYTEPYYYKAEDEEDYTEPVADNETDYVEVMEQVLAKLENRTSITETDEQMQAYDHLSYETPYETPQDEGYDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPEQPVEITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQVCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDFVQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAVMSTLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDNCHELYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNNIQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQMSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSKDAVGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRKQGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA
Protein: Cag pathogenicity island protein (Cag16) (O25270)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- Cag pathogenicity island protein
- Cag pathogenicity island protein
- Cag pathogenicity island protein
- Restriction endonuclease
- CAG pathogenicity island protein 12
- Cag pathogenicity island protein
- Acyl carrier protein
Sequence:
MLAKIVFSSLVAFGVLSANVEQFGSFFNEIKKEQEEVAAKEDALKARKKLLNNTHDFLEDLIFRKQKIKELMDHRAKVLSDLENKYKKEKEALEKETRGKILTAKSKAYGDLEQALKDNPLYRKLLPNPYAYVLNQETFTKEDRERLSYYYPQVKTSSIFKKTTATTKDKAQALLQMGVFSLDEEQNKKASRLALSYKQAIEEYSNNVSNLLSRKELDNIDYYLQLERNKFDSKAKDIAQKATNTLIFNSERLAFSMAIDKINEKYLRGYEAFSNLLKNVKDDVELNTLTKNFTNQKLSFAQKQKLCLLVLDSFNFDTQSKKSILKKTNEYNIFVDSDPMMSDKTTMQKEHYKIFNFFKTVVSAYRNNVAKNNPFE
Protein: Homeobox protein Six7 (SIX homeobox 7) (Sine oculis homeobox homolog 7) (O93282)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MFPLPMFTPEQVARVCENLEETGDIERLGRFLWSLPAAVPGSAGELLNRHESVMRARALVAFHGGNFEALYQILQSHRFTRESHAKLQDLWLDAHYREAERLRGRPLGPVEKYRIRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSRKRHLAQATGLTPTQVGNWFKNRRQRDRAASAKNRLQQDSSLLPSGSSPECSSSEHNPLLRGSSPRHPDSPGNSDCSSGPRGTGASTPDISVSSDSEFES
Protein: Aquaporin 8b (Aquaporin-8) (C0HB60)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Aquaporin
- Aquaporin
- Aquaporin
- Aquaporin
Sequence:
MTEGTMELGDVGTSLMASDSKKAPVKPPNKFERLVQPCLAELVGTMFFVFIGCVSVIENVEAAGRLQPALVHGLAVAVMVACMAEISGSHFNPPFTIAIYLCGGMKLNMVGPYLISQLIGGVLGASMSKLMTTTENYSKAQGAAFALLQSQDQLWGALFGEIAMTCLVTMVVLLGAVNAKSSSPMVPFMVGCTVIINILAGGDVSGTCLNPARALGPAIVANYWTYHWVYWVGPITGGLVAAALVRLLLGDRKTRILMK
Protein: RNA helicase (EC 3.6.4.13) (E3MYG7)
Organism: Caenorhabditis remanei (Caenorhabditis vulgaris)
Interaction partners:
- Pre-mRNA-processing factor 6
- CRE-EFT-1 protein
- Pescadillo homolog
- Uncharacterized protein
- RNA-binding protein 8A
- CRE-MAG-1 protein
- U6 snRNA-associated Sm-like protein LSm7
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
Sequence:
MNTQYYANQNGQQQQPGQGWSSSSYSQQGNVASSGYYSGGFGQTSSPSNGYAIQQSMAPNGMGQMVSSQQTGYIPPYYPGQQQFQMGYSENFENFEDNGSSNGYNNFSDSGNGYNNKCYSGGETNGWGGASAEYTADNLFHRTNSGINFDKYENIPVEVSGDAVPAAIENFSEAGFGPAVMENVTHSGYTKPTPVQKHSIPTLLANRDLMSCAQTGSGKTAAFLLPIIQHIMAGGPEMIKTPAFTNGRRTYFPSALVLSPTRELAIQIHKEASKFSYKTNLQTAILYGGRENYRDQVNRLRSGAHILIATPGRLIDIIEQGFIGLAGCRYLVLDEADRMLDMGFEPQIRKIVGQGMPAKTARTTAMFSATFPKEIQLLAKDFLKENYVFLAVGRVGSTSENIEQRLLWVNEMEKRQNLMEILMNEDSTNLVLVFVETKRGANELAYFLNRQQIRSVSIHGDLKQIERERNLEMFRSGQFPILVATAVAARGLDIPNVRHVINYDLPGDSDEYVHRIGRTGRCGNLGIATSFFNDKNRGIGRDLKNLILEANQEVPDWLHQVAAEGRIGGGQRGGNRRFGATDYRRGNGGGSFAGNFNSYNAGGQSAGFGGGSGFGGAFGATRRPFTNGGFGAQSSLSSSSNGGSGGGFGGPRRGGFNNGMSRQNGGGFYSNGGPPATIDHWQAPRA
Protein: Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (O08749)
Organism: Mus musculus (Mouse)
Function: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). In monomeric form may have additional moonlighting function as serine protease. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000305|PubMed:36854377, ECO:0000305|PubMed:9169128}. Nucleus {ECO:0000250|UniProtKB:P09622}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q811C4}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15888450}. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. {ECO:0000250|UniProtKB:P09622}.
Interaction partners:
- Pyruvate dehydrogenase protein X component, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- 2-oxoglutarate dehydrogenase-like, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Sequence:
MQSWSRVYRSLAKKGHFNRISHGLQGVSSVPLRTYADQPIEADVTVIGSGPGGYVAAIKSAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEIPEVRLNLEKMMEQKHSAVKALTGGIAHLFKQNKVVHVNGFGKITGKNQVTATKADGSTQVIDTKNILVATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKLVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGIGIDMEISKNFQRILQRQGFKFKLNTKVTGATKKSDGKIDVSVEAASGGKAEVITCDVLLVCIGRRPFTQNLGLEELGIELDPKGRIPVNNRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEFKIGKFPFAANSRAKTNADTDGMVKILGHKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAAAFGKPINF
Protein: Putative clathrin assembly protein At5g57200 (Q9LVD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane, clathrin-coated pit {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Note=Colocalized with clathrin in the Golgi area. {ECO:0000250}.
Interaction partners:
- Ribosome biogenesis protein NOP53
- Reverse transcriptase
- F21D18.12
- Nonsense-mediated mRNA decay factor SMG7-like
- MADS-box transcription factor family protein
- MADS-box transcription factor family protein
- AT4g03420/F9H3_4
- MADS-box protein AGL35
- Calcium-transporting ATPase 2, endoplasmic reticulum-type
- At5g27810
Sequence:
MGTFTSFRKAYGALKDTTTVGLAKVNSEFKDLDIAIVKATNHVESPPKERHVRKIFSATSVIQPRADVAYCIHALSKRLSKTRNWVVAMKVLIVIHRTLREGDPTFREELLNYSHRRHILRISNFKDDTSPLAWDCSAWVRTYALFLEERLECYRVLKYDIEAERLPKASGAASKTHRTRMLSGEDLLEQLPALQQLLYRLIGCQPEGAAYSNYLIQYALALVLKESFKIYCAINDGIINLVDMFFEMSRHDAVKALNIYKRAGQQAENLAEFYDYCKGLELARNFQFPTLRQPPPSFLATMEEYIKEAPQSGSVQKKLEYQEKEEEEQEQEEEQPEEPAEEENQNENTENDQPLIEEEEEEPKEEIEVEEAKPSPLIDTDDLLGLHEINPKAAEIEQNNAFSLAIYPPGHETSAPSNSLSLIEAGGSGWELALVTPQNNNNNNNNPRPVIATKLGGGFDNLLLDSLYEDDTARRQIQLTNAGYGFGATAIPGALASSNPNPFGVQQDPFAMSNNMAPPTNVQMAMQQQQMMMMNNQSPYNNNYSPYHHHQFSPNPSTSSSPNPFGDPFLALPAPPSSTTQQQYSPNHMLL
Protein: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) (H0YL72)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGPAWISKVSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVKDLD
Protein: dTMP kinase (EC 2.7.4.9) (D3ZUJ5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Thymidine kinase, cytosolic
- Thymidylate synthase
- Ribonucleoside-diphosphate reductase
- Thymidine kinase 2, mitochondrial
- Deoxycytidylate deaminase
- Adenylate kinase 9
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Nucleoside diphosphate kinase A
- Nucleoside diphosphate kinase B
- Nucleoside diphosphate kinase 6
Sequence:
GFLICGSWKPVPGLRSILFFRPLIKAKLNQGVTLVLDRYAFSGVAFTSAKENFSLDWCKQPDVGLPKPDLILFLQLQLLDAASRGEFGLERYETGTFQEQVLLCFQQLMSEKNLNWKVVDASKSIEDVHEEIRALSEDAIQNAAQRPLEELWK
Protein: GEO01805p1 (IP02725p) (SKP1-related B) (SKPB) (Q7KJ69)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- S-phase kinase-associated protein 2
- Cullin homolog 1
- Cullin 6
- Supernumerary limbs, isoform B
- RING-box protein 1B
- Calcyclin-binding protein
- JmjC domain-containing histone demethylation protein 1
- F-box-like/WD repeat-containing protein ebi
- Transcriptional activator cubitus interruptus
- APC-like, isoform A
Sequence:
MPIIRLESADKEIFDTDQEIAKCSETIRIAIEDLGDESDNSVLPLPNVNSLILKKVLHWATYHKDDPVVTEEVENKEKRTDDISSWDADFLKVDQGTLFELILAANYLNIQGLLDVTCKTVANMIKGKSPQAIRDTFAIQNDFLPQEEEQVRKENEWCEDK
Protein: TFIIH basal transcription factor subunit (Q382C6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- TFIIH basal transcription factor subunit
- TFIIH basal transcription factor subunit
- TFIIH basal transcription factor subunit
- TFIIH basal transcription factor subunit
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
Sequence:
MDVWDASLPGAGARRATTILQVYMRMGNYSPLSILVADSLCLTFKSDGATVAELGAYLGLTQDRVEIGINGMPREVYCTSLEFSHGDEYGENEQQRKDGAEKEWEGTSGIRKETQDTDEGGGMRYYINYATFLPFAYAHGSHMLLALCQLPLPKRVEGTVNSGELSNISISPNLRRVDCRSGLCCVNCRYWMGLWDLRSTIVKCPLCQADILDGILRDIRSRYNNKLADGRQLLVFGPVQQRQPCPQQRSGESAENTKGNAPKVGSDDTTNYPLARDPFLVQQALFFKFLYLHPFVCVNVGSFAVDADEVMTREEYAHRSKHKATVLDQFRLVHRNPSAIRVHLVDQVKVDEEKYAQAAKRLAKRVQLPPWLQSADLSSSATVLKSLLALRRTEERTGGSKRTRRDRDVTSIASYVAREFFDDDFVEIPLRREFSI
Protein: Homeobox protein ARX (Aristaless-related homeobox) (Q96QS3)
Organism: Homo sapiens (Human)
Function: Transcription factor. Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C. Positively modulates transcription of KDM5C. Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. Required for normal brain development. Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Interaction partners:
- Protocadherin-19
- Cyclin-dependent kinase-like 5
- Syntaxin-binding protein 1
- Mitochondrial glutamate carrier 1
- Sodium channel protein type 1 subunit alpha
- Bifunctional polynucleotide phosphatase/kinase
- Importin-13
- Spectrin alpha chain, non-erythrocytic 1
Sequence:
MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAQSLPAPLTSRADPEKAVQGSPKSSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAAATATAGPRGEAPPPPPPTARPGERPDGAGAAAAAAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELGGPGGVTHPEERLGVAGGPGSAPAAGGGTGTEDDEEELLEDEEDEDEEEELLEDDEEELLEDDARALLKEPRRCPVAATGAVAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKEVC
Protein: Microphthalmia-associated transcription factor (O88368)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O75030}. Cytoplasm {ECO:0000250|UniProtKB:O75030}. Note=Found exclusively in the nucleus upon phosphorylation. {ECO:0000250|UniProtKB:O75030}.
Interaction partners:
- Transcription factor binding to IGHM enhancer 3
- Transcription factor EB
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
- Tyrosinase
- Transcription factor PU.1
- Paired box protein Pax-6
- Lysine--tRNA ligase
- Protein c-Fos
Sequence:
MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSSSSAEHSGASKPPLSSSTMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVAVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRHQVKQYLSTTLANKHAGQVLSPPCPNQPGDHAMPPVPGSSAPNSPMAMLTLNSNCEKEAFYKFEEQSRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHANRHLLLRVQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQELVQHQADLTCTTTLDLTDGTISFTNNLGTMPESSPAYSIPRKMASNLEDILMDDALSPVGVTDPLLSSVSPGASKTSSRRSSMSAEETEHAC
Protein: T-complex protein 1 subunit epsilon (CCT-epsilon) (V9HW37)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
Protein: Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g) (P59901)
Organism: Homo sapiens (Human)
Function: Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16735691, ECO:0000269|PubMed:19564354, ECO:0000269|PubMed:24586760, ECO:0000269|PubMed:26172439}; Single-pass type I membrane protein {ECO:0000305|PubMed:16735691, ECO:0000305|PubMed:19564354, ECO:0000305|PubMed:24586760, ECO:0000305|PubMed:26172439}.
Interaction partners:
- Bone marrow stromal antigen 2
- High affinity immunoglobulin epsilon receptor subunit gamma
- Tyrosine-protein kinase SYK
- Low affinity immunoglobulin gamma Fc region receptor III-A
- Tyrosine-protein phosphatase non-receptor type 6
- T-cell surface glycoprotein CD3 zeta chain
- C-type lectin domain family 4 member C
- High affinity immunoglobulin epsilon receptor subunit beta
- CMRF35-like molecule 6
- High affinity immunoglobulin epsilon receptor subunit alpha
Sequence:
MTLILTSLLFFGLSLGPRTRVQAENLLKPILWAEPGPVITWHNPVTIWCQGTLEAQGYRLDKEGNSMSRHILKTLESENKVKLSIPSMMWEHAGRYHCYYQSPAGWSEPSDPLELVVTAYSRPTLSALPSPVVTSGVNVTLRCASRLGLGRFTLIEEGDHRLSWTLNSHQHNHGKFQALFPMGPLTFSNRGTFRCYGYENNTPYVWSEPSDPLQLLVSGVSRKPSLLTLQGPVVTPGENLTLQCGSDVGYIRYTLYKEGADGLPQRPGRQPQAGLSQANFTLSPVSRSYGGQYRCYGAHNVSSEWSAPSDPLDILIAGQISDRPSLSVQPGPTVTSGEKVTLLCQSWDPMFTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGSRSSNPYLLSHPSEPLELVVSGATETLNPAQKKSDSKTAPHLQDYTVENLIRMGVAGLVLLFLGILLFEAQHSQRSPPRCSQEANSRKDNAPFRVVEPWEQI
Protein: F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19) (Q6PB97)
Organism: Mus musculus (Mouse)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (By similarity).
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
- Lysine-specific demethylase 7A
- Ubiquitin-like protein NEDD8
- Histone lysine demethylase PHF8
Sequence:
MSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEDEKFSLSLMECTICNEIVHPGCLKMGKAEGVINSEIPNCWECPRCTQEGRTSKDAGEGPGRRRADNGEEGANLGGGWKLTEEPPPPPPLPRRKGPLPAGPTPDDVPGPPKRKEREGGNEPPTPRKKVKGGRERHLKKVGGDACLLRGADPGSPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPIASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAIRPGTGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS
Protein: HTH-type transcriptional regulator BhcR (Bhc regulatory protein) (A1B8Z4)
Organism: Paracoccus denitrificans (strain Pd 1222)
Function: Transcriptional regulator of the bhc gene cluster involved in glycolate and glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Glyoxylate negatively affects the interaction of BhcR with the promoter region of the bhc gene cluster.
Interaction partners:
- Allophanate hydrolase subunit 2
- 3-hydroxy-D-aspartate aldolase
Sequence:
MSVQIRKRGRPRGRAGGLGAEDSGGIRALDRALDILDLIAVSSGLTLTEIAQRLDMAPSTVHRVLVTLAARGVAESDSQTQAWHVGPTAFRHGSAFMRRSGLVERARPLLRRLMEVTGETANLGILNGDAVLFLSQAETHETIRAFFPPGTRSALHASGIGKALLAHARPLDLKRMLREMRLERFTDMTLTDPAALVEDLVQIRARGYALDNEERTPGMRCIAAPIFDLAGEAAAGISVSGPTLRMSDARLSAMSDAVIEAARELSFGMAPRKDAGERA
Protein: Partner of Y14 and mago (DmPYM) (Protein within the bgcn gene intron) (P82804)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor by disrupting mature EJC from spliced mRNAs. Required for normal localization of osk mRNA to the posterior pole of the developing oocyte. Does not interact with the small ribosomal unit or components of the translation initiation complex. May not function in cap-dependent translation regulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14968132, ECO:0000269|PubMed:24967911}. Nucleus {ECO:0000269|PubMed:14968132}. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by emb/Crm1. {ECO:0000269|PubMed:14968132, ECO:0000269|PubMed:24967911}.
Interaction partners:
- Protein mago nashi
- RNA-binding protein 8A
- RE04053p
- Ranshi
- Serine/arginine repetitive matrix protein 1
Sequence:
MSTYLQSSEGKFIPATKRPDGTWRKARRVKDGYVPQEEVPLYESKGKQFVAQRQAGVPPGMCPLLAAESKKEREKQERTRAKKQEKESGRQPKAPAPGVLVMPPSTCPPPKVSQQQQQQQQQPSGSRDINSISKTLEDTLKLDAAQEVVDPAKQLKKLRKKIREIEQIESRIQAGEQKKLDKDQLDKVKKKSEILRQIKDLESTPRS
Protein: SD09427p (U4-U6 small nuclear riboprotein factor 60K) (Q9VVI0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Precursor RNA processing 3, isoform A
- Pre-mRNA-processing factor 6
- U4/U6 small nuclear ribonucleoprotein Prp31
- RE11167p
- 116 kDa U5 small nuclear ribonucleoprotein component
- U6 snRNA-associated Sm-like protein LSm7
- Pre-mRNA-processing-splicing factor 8
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- U6 snRNA-associated Sm-like protein LSm8
- Peptidyl-prolyl cis-trans isomerase
Sequence:
MSDDDDIQYIKRQRTLHYGSLEESERKRQNAAASGAAATTTSGTTASSGAGTTTTGTGGQLEDIDSDEDYEESTKKTSNAKQAGAPPPTAATLANKIDDDYFDLEMEMERDKVALLEEFERKKRARQINVSTDDTEIKSNLRQLNEPICYFGEGPAERRRRLKELLAGLGENAINKRQYEDEERKQQQREQDQATWYHEGPDSLRIARLWLADYSLPRAKDRLVRAREALEVPSAARAGRMVEMQKKLQSLAPLCSQVGDTRPVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLRGHASYVGGVALRPGVKADEENVVAMASGGHDGAVKLWGFNNEESIADITGHMPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQECGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWSPDS
Protein: Uncharacterized protein (Q381N4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVKRSPSPSVDSVERIYDMLCAAQLKANTEEEEIRALRLLIATAEVEIKTAQESMRELQEQHEEASREVSVKKSTLEEQRHRCVGAVEALASSREALTREIEDILRSELPPHPAVSAVKKTVRSSYEIISPAKLRDAALSLRRKIEEAIKHHHLCCEQNQSPSSIGDGWGDSKKGFRHSFVVHFKCAEAAVSNTGDEAAGAVPEPRHVSAARVELNVGKDANDTLGKRKRKVITFDDEQLEAHSAAFRPSAAAVATPRPSSISCDLTIIRPRLPRRTLWRAEQRELS