wanglab/gogpt-training-data huggingface dataset:
Protein: Diacylglycerol O-acyltransferase 1B (GmDGAT1B) (EC 2.3.1.20) (I1MSF2)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Major contributors to triacylglycerol (TAG) synthesis and oil accumulation in developing seeds. Catalyzes the acylation of the sn-3 hydroxy group of sn-1,2-diacylglycerol using acyl-CoA. Has a marked preference for oleoyl-CoA and sn-1,2-dioleoylglycerol over vernoloyl-CoA and sn-1,2-divernoloylglycerol.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5GKZ7}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Diacylglycerol O-acyltransferase 2D
- Diacylglycerol O-acyltransferase 3-2
- Diacylglycerol O-acyltransferase 3-1
- Acyltransferase
- Acyltransferase
- Acyltransferase
- Diacylglycerol O-acyltransferase 1A
- diacylglycerol O-acyltransferase
- phosphatidate phosphatase
- phosphatidate phosphatase
Sequence:
MAISDEPESVATALNHSSLRRRPSATSTAGLFNSPETTTDSSGDDLAKDSGSDDSINSDDAAVNSQQQNEKQDTDFSVLKFAYRPSVPAHRKVKESPLSSDTIFRQSHAGLFNLCIVVLVAVNSRLIIENLMKYGWLIKSGFWFSSKSLRDWPLFMCCLSLVVFPFAAFIVEKLAQRKCIPEPVVVVLHIIITSTSLFYPVLVILRCDSAFVSGVTLMLFSCVVWLKLVSYAHTNYDMRALTKLVEKGEALLDTLNMDYPYNVSFKSLAYFLVAPTLCYQPSYPRTPYIRKGWLFRQLVKLIIFTGVMGFIIEQYINPIVQNSQHPLKGNLLYATERVLKLSVPNLYVWLCMFYCFFHLWLNILAELLRFGDREFYKDWWNAKTVEDYWRMWNMPVHKWMIRHLYFPCLRHGLPKAAALLIAFLVSALFHELCIAVPCHIFKLWAFGGIMFQVPLVLITNYLQNKFRNSMVGNMIFWFIFSILGQPMCVLLYYHDLMNRKGKLD
Protein: Brain-derived neurotrophic factor (proBDNF) (B4Z8L9)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU364086}.
Interaction partners:
Sequence:
VISYFSCMKAAPMKEASVRGHGSLAYPGLRTHGTLESLTGPNAGSRGLTSLADTFEHVIEELLDEDQDIQPSEENKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCNPKGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDNKKRVGWRFIRID
Protein: Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) (Q9H9S0)
Organism: Homo sapiens (Human)
Function: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15983365}.
Interaction partners:
- Sal-like protein 4
- POU domain, class 5, transcription factor 1
- Transcription factor SOX-2
- Signal transducer and activator of transcription 3
- Krueppel-like factor 4
- Methylcytosine dioxygenase TET1
- CD44 antigen
- Protein lin-28 homolog A
- Homeobox protein NANOGP8
- PR domain zinc finger protein 14
Sequence:
MSVDPACPQSLPCFEASDCKESSPMPVICGPEENYPSLQMSSAEMPHTETVSPLPSSMDLLIQDSPDSSTSPKGKQPTSAEKSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWPKNSNGVTQKASAPTYPSLYSSYHQGCLVNPTGNLPMWSNQTWNNSTWSNQTQNIQSWSNHSWNTQTWCTQSWNNQAWNSPFYNCGEESLQSCMQFQPNSPASDLEAALEAAGEGLNVIQQTTRYFSTPQTMDLFLNYSMNMQPEDV
Protein: UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase (EC 6.3.2.45) (Murein peptide ligase) (UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase) (Q9HX07)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
- Beta-hexosaminidase
- Flavin prenyltransferase UbiX
- Peptidoglycan D,D-transpeptidase FtsI
- Beta-lactamase
- AmpG
- UDP-N-acetylmuramoylalanine--D-glutamate ligase
- YceK/YidQ family lipoprotein
- UDP-N-acetylglucosamine--N-acetylmuramyl-
Sequence:
MHIHVLGICGTFMGSLAVLAKELGHRVTGSDANVYPPMSTQLQAQGIELMQGYDPAHLEPAPDLVVIGNALSRGNPAVEHVLNKGLPYVSGPQWLADHVLQGRWVLAVAGTHGKTTTTSMLAWVLEHAGMSPGFLIGGVPQNFGVSARLGGTPFFVVEADEYDSAFFDKRSKFVHYRPRTAILNNLEFDHADIFPDLAAIERQFHHLVRTVPGEGLIIRPSAEKALERVLGMGCWTPVQTTGEGGQWQARLLAEDGSRFEVLFDGIVQGEVDWPLTGLHNVANALASLAAARHVGVMPSQGAAALSEFRNVKRRMEKVAEVRGVTLYDDFAHHPTAIATTLDGLRKQVGADTQVIAIVEPRSNSMKLGAHRDGLPDSVRQADQVLWYAPPNLGWDLAATAAQCAIPSQVCDTLEAIIEQVRQQARPGAQVVIMSNGGFGGLHGKLAAALAE
Protein: Caveolin (Q6YLH9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680}. Golgi apparatus membrane {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein {ECO:0000256|RuleBase:RU000680}. Membrane, caveola {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein {ECO:0000256|RuleBase:RU000680}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}.
Interaction partners:
- Proto-oncogene tyrosine-protein kinase Src
- Caveolin
- Tyrosine-protein kinase fyna
- Caveolae-associated protein 1b
- Tyrosine-protein kinase fynb
- Dynamin-2
- Protein Wnt
- Low density lipoprotein receptor-related protein 4
- Caveolae-associated protein 1
- Epidermal growth factor receptor precursor.
Sequence:
MTSGYKDGTPEEEYAHSPFIRKQGNIYKPNNKEMDNDSINEKTLQDVHTKEIDLVNRDPKHLNDDVVKVDFEDVIAEPAGTYSFDGVWKASFTTFTVTKYWCYRLLTALVGIPLALVWGIFFAILSFIHIWAVVPCVKSYLIEIHCISRVYSICVHTFCDPLFEAMGKCFSNVRVTATKVV
Protein: Chlorophyllide a oxygenase, chloroplastic (Chlorophyll a oxygenase) (EC 1.14.13.122) (Chlorophyll b synthase) (AtCAO) (Q9MBA1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes a two-step oxygenase reaction involved in the synthesis of chlorophyll b. Acts specifically on the non-esterified chlorophyllide a and not on chlorophyll a.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:15086960}; Peripheral membrane protein. Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:15086960}; Peripheral membrane protein.
Interaction partners:
- Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic
- Protochlorophyllide reductase A, chloroplastic
- Chlorophyll synthase, chloroplastic
- Chlorophyll
- Probable chlorophyll
- Protochlorophyllide reductase C, chloroplastic
- Protochlorophyllide reductase B, chloroplastic
- Chlorophyllase-1
- Chlorophyllase-2
- Magnesium dechelatase SGRL, chloroplastic
Sequence:
MNAAVFSPSALSLPISFSKTRSSFLSRKKGVKGEFRVFAVFGDESGLVEKKSQWRPLFDVEDPRSKAPPYKGKFLDVNQAIEVARFDIQYLDWRARQDLLTIMILHDKVVDVLNPLAREYKSIGTVKKELAGLQEELSKAHQQVHISEARVSTALDKLAHMEELVNDRLLPGRVVTELDKPSSSTTASAVELDREKTNTGAKSLNVSGPVPPYSPHLKNFWYPVAFTADLKHDTMVPIECFEQPWVIFRGEDGKPGCVRNTCAHRACPLDLGTVNEGRIQCPYHGWEYSTDGECKKMPSTKLLKVKIKSLPCLEQEGMIWIWPGDEPPAPILPSLQPPSGFLIHAELVMDLPVEHGLLLDNLLDLAHAPFTHTSTFAKGWSVPSLVKFLTPTSGLQGYWDPYPIDMEFKPPCIVLSTIGISKPGKLEGKSTQQCATHLHQLHVCLPSSKNKTRLLYRMSLDFAPILKNLPFMEHLWRHFAEQVLNEDLRLVLGQQERMLNGANIWNLPVAYDKLGVRYRLWRNAVDRGDDKLPFSG
Protein: Mitochondrial antiviral-signaling protein (B8A4W7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Interferon-induced with helicase C domain 1.
- TNF receptor-associated factor
- TNF receptor-associated factor 6
- NLR family member X1
- Stimulator of interferon genes protein
- ATP-dependent RNA helicase DHX33
- Serine/threonine-protein kinase TBK1
- NOD2a protein
- Interferon regulatory factor 3
- Autophagy protein 5
Sequence:
MSLTREQFYNKGIRPYMGRFATDIKVREILPYLQCLTISDREEIEAKKEQYGNYNAVQTLLDNLRRRENWIDEFITALRKCELGSLANEMSDIYDRIRGITSGPKPTDTLAPSLTGATATVTTATVHTVPPTTLPLLMPPAGDAPVHSTAPCKQATQEPSPDSVLQVAETQQVEQVSPPAPAPTPEPVPQTEITPQVIAPSQAAPDMSSPINLKVLTHTGEAVTITPVSRALDSLGFTITSSAGESPISTSCTQASISNTSQIQLTRPCSTTQSSGNIQVPKKEVKDLDTSEKFPVQDTNLPLRQERTFQGPEETSDPIANEVPTGKVLEQGWNHTMQDCGPPGTEFDIPAKSKQCKTPSSKLV
Protein: Putative N(omega)-hydroxy-L-arginine synthase DcsA (D2Z024)
Organism: Streptomyces lavendulae
Function: Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Could catalyze the production of N(omega)-hydroxy-L-arginine (NHA) from L-arginine.
Interaction partners:
Sequence:
MNCYPAGHLLGKGHVQLNESGENAELISQEQIGDDLNGWHRDAFEDIASRLTDPGFPCVFSRNAFRKKLVKFVFVEGSGKEDIRHLGAGLKDYVELSRDWDGALDTAYPLVVVFSADAVTADSVEQYHAFGWWVLQELHAIDPTPWPEGVDKGPQSEAWSMCFHGMPLFINMSSPAHQVRRSRNLGRHFALVINPRERFDVFAGDTPSGRKVRSNIRGRIARYDGTPHAQQLGSYGTGALEWMQYGLVEENRERADVCPFTFRGA
Protein: Dag7p (Q5AMF9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Elongator complex protein 4
- Elongator subunit
- Elongator complex protein 3
- Elongator complex protein 2
- Elongator subunit
Sequence:
MKFSSVVLSALLANLVASAPIKTVIVTAFTTVLVDSKGNTKIQTEAATATATLSGNAAAANTDVTQEYNTPSTTFTATSYNNNNNWASAPSSVETSIVEPATSEIIEPSTTNNIQTTLSTQTTSSPSTTSATSSSSSSSSSAQPTGSEFSGEGTFYSTGLGSCGITSTDSDFIVAISHELYDSKSVGNNPNHNPLCNKKIRAFYEGKSVDVTVVDRCEGCAYNDLDFSPAAFDKLADESLGRIDITWEWLN
Protein: ACT domain-containing protein ACR8 (Protein ACT DOMAIN REPEATS 8) (Q9LNA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May bind amino acids.
Interaction partners:
- At4g25315
- WAT1-related protein At5g40240
- Similarity to Ta11-like non-LTR retroelement protein
- ACT domain-containing protein ACR11
- At4g01000
- Probable acyl-activating enzyme 18, peroxisomal
- Adenylate kinase 2, chloroplastic
Sequence:
MAMKGYLDEYEKLVIRMNTPRVVIDNGVCSSATIVKVDSSRRNGILLEAVQILTDLNLSIKKAYISSDGTWNMDVFHVTDLNGNKLNDQSVLRYIEQSIETVYYGENIEVNGLTALELTGTDRIGLLSEMFAVLSDLNCDVVDAKLWTHNGRVASVIYLKDCISGAPILDSHRISKIEGRLKNVLNGDNDVNSAAKTCVTVDSMMHIERRLHQLMFEDRDYERRSKKHERSPMVVVTVQNWAERGYSVVNVHCRDRTKLLFDVVCTLTDMEYAVFHATINTAEDQAHLEFYIRHKDGSPISSEAERQRVIQCLEAAVERRALEGVRLELRHPDKQGLLAEVTRTFRENGLNVTRTEISTSSDMATNIFYVTDANGDEPDFKLIESVREKIGLECLRVKEMPTMYHKKGDGEEQQQTKAVLVSLGSLVWRNLFNFGLIKSCS
Protein: Polyadenylate-binding protein (PABP) (E7EQV3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU362004}.
Interaction partners:
Sequence:
MITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
Protein: Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit beta-1) (K(VCA)beta-1) (Maxi K channel subunit beta-1) (Slo-beta-1) (Slo-beta) (Q8CAE3)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Calcium-activated potassium channel subunit alpha-1
- Calcium-activated potassium channel subunit beta-4
- Potassium channel subfamily U member 1 current)
- Small conductance calcium-activated potassium channel protein 1
- Intermediate conductance calcium-activated potassium channel protein 4
- Small conductance calcium-activated potassium channel protein 2
- Small conductance calcium-activated potassium channel protein 3
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- cGMP-dependent protein kinase 1
Sequence:
MGKKLVMAQKRGETRALCLGVAMVVCAAITYYVLGTTVLPLYQKSVWTQESICHLIETNIKDQEELEGKKVPQYPCLWVNVSAVGRWAMLYHTEDTRDQNQQCSYIPRNLDNYQTALADVKKVRANFYKHHEFYCLSAPQVNETSVVYQRLYGPQVLLFSFFWPTFLLTGGLLLIAMVKLNRSLSILAAQK
Protein: LAGLIDADG endonuclease (H9D0N7)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- quinol--cytochrome-c reductase
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- NADH-ubiquinone oxidoreductase chain 1
- 4Fe-4S ferredoxin-type domain-containing protein
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial [Precursor]
- NADH-quinone oxidoreductase subunit D domain-containing protein
- Cytochrome b-c1 complex subunit 7
Sequence:
MTRGKSAGVRSLHTSEASQRLHAGDLTYAYLVGLFEGDGYFSITKKGKYLTYELGIELSIKDVQLIYKIKKILGIGIVSFRKRNEIEMVALRIRDKNHLKSFILPIFEKYPMFSNKQYDYLRFRNALLSGIISLEDLPDYTRSDEPLNSIESIINTSYFSAWLVGFIEAEGCFSVYKLNKDDDYLIASFDIAQRDGDILISAIRKYLSFTTKVYLDKTNCSKLKVTSVRSVENIIKFLQNAPVKLLGNKKLQYLLWLKQLRKISRYSEKIKIPSNY
Protein: Photosystem II CP47 reaction center protein (PSII 47 kDa protein) (Protein CP-47) (P0C364)
Organism: Oryza sativa subsp. japonica (Rice)
Function: One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01495}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01495}.
Interaction partners:
- Photosystem II protein D1
- Photosystem II D2 protein
- Cytochrome b559 subunit alpha
- Cytochrome b559 subunit beta
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein L
- Photosystem II reaction center protein H
- Photosystem I iron-sulfur center
- Cytochrome c oxidase subunit 3
- Photosystem II reaction center protein K
Sequence:
MGLPWYRVHTVVLNDPGRLLSVHIMHTALVSGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWSISGGTVTNPGIWSYEGVAGAHIVFSGLCFLAAIWHWVYWDLEIFCDERTGKPSLDLPKIFGIHLFLAGVACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQAVNPAWGAEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVSDGLAENLSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAVGWLGHPIFRDKEGRELFVRRMPTFFETFPVVLVDEEGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPATVKKYARRSQLGEIFELDRATLKSDGVFRSSPRGWFTFGHATFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGTFQKVGDPTTRRQPV
Protein: PRELI domain-containing protein 2 (Q0VBB0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGVTVDVHQVFQYPFEQVVACFLRKYPNPMDKNVISVKTVEEKKDESTGLIYRKRIAICQNVVPEILRKVSILKVPDIQLEEESWLSLQKRNMAIRSHCLTWTQYASMREESVFRESVENPNWTEFIQTGRISITGAGFLNCILETFASTFLRQGAQKGIRIMEMLLKEQCGSPLVE
Protein: AMP deaminase, putative (Q386C9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Bifunctional dihydrofolate reductase-thymidylate synthase
Sequence:
MGQRWHDILIAGDEGDRSFSDAAPFVVEALEIIFHTRLLHSGVGVECDSAELSTIKDDHLAFRVARKDVEALRGMMATLLESAHDSLLTLQAADILPDDSAENAVNPGRSLLSCDRGLVSPRILKLNPFLRSHPTFDYKVFRAKFERLCQIVADARLFSACEPRVKILQSRYRLYRAFNMRREEHFHPTLGPGNLRRAPKTDVRRVGTCMSASSVVDFVQKTVSNEPNLVLSTSSVLSTATDKGRARNPIGRGFTSEVQLAVPQQTFSMPTKDSGTHDSTGERTVTLKALADAFFGPSLPPQDRVFTMEGLGLRLSSSKTTSHTVDILEARNEHHTAANAVPILRQFLDVYSGNGGALLGRLVTPMISRISRNKKDVLEVEFTVTGHRPGEVQHIASWCVRTGFFASGGNWPSLRITMRPSAGDGGECTAKSMEDVLKHIFEPIWLALLCPEKYPDVAQLFRRLVSVSVLVSGEAGVQEMPTEGDPAMYSVEKGDMPPSSFFIYHVWRNVQLLNCFIATHVVSSLSAKEPPTSTTEDVKVEFGNSTAHPSHVQRPLFQRYEPLKRQPLRFRLYTSGTRKKTFVETVIGLLVTDQVVGPLEVLAWSSLTYFYYLTQRSIVVTPYHTYDSTPYSMLKRAIPFAVETGLRVSVSTIDPLYFHTNEEALNEELNGIMKIHQVSTPEVMEICLNSAGYINFDIEKRCKFIGGPWRRVSAQNNNFTVTQVNSLRLRFRELSLTHEMDLLFRKGLTKWGGHSESKRLSEDFLVHGGWSLLATGSSASTSAERRRENLWRFFDIPPLPEKVSGAMTMPGSGRRLFVDKLIKFPRIVVLGPRGRKRSEARCVVEALQRREYYKAFTVHYELAAPLASLAGTAGVEALLASQRSSRSSGRGFTSTEKWREHHDKGEQTQQPSTRASGNISSSIRSFSSPVVREQGVTVPTTFCFRDGVRDVVVPANANATTKEYFRPLPSWAKFQADARQLRALSSDSSMLRYANRRLDMLECKFNLHVALTNDDQETQEGHLTDMLREKSDIYKCVKVDVHCHMASGMTAKELLKFIKEKVRMNRNDVVDIDRSTGFPITLGELFAKIHAEKLSGTTFDVEDLTIASLNVKAGKATFNRFDVFNGRYSPLGQSALRSLLLKTDNFIGGRYFAELIRTVFDRQAADGYSFSEYRLSIYGRCHDEWDRLSRWFLTHDMLHPTNRWIVQVPRLYGIYRQNKILSSFEDLLTNIFLPLWQASIDPEKHPFLNYFLAHVSGFDLVDNESERETDSLINTSPSQWTSVENPPFMYWLYYMWANITSLNRYRAARGLTTFSLRPHAGESGDPGHMAEAFLVADGVNHGINLKDTPVLQYLYYLGQIPLGITPLSNNALFCRYNENPFALFFRRGLNVALSTDGALIFHHTEEPLIEEYSTAANYWNLSQVDLCEIAKNSVLMSGFPSYRKKKWLGELYALRSAVGNDMRLTRVPQSRCTFRYEVYLEELSYLEAVASKEVSPSQIMTWQLEGLYTMTTLGLTRDEVMKQRLKNQGVGEYASPVESRTKATTVLTGPIIVAPSRL
Protein: Organic cation/carnitine transporter 5 (AtOCT5) (Q9SAK7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High affinity carnitine transporter involved in the active cellular uptake of carnitine. Also transports organic cations (By similarity).
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:18710496}; Multi-pass membrane protein {ECO:0000269|PubMed:18710496}.
Interaction partners:
- Adenine nucleotide alpha hydrolases-like superfamily protein
- Protein FLX-like 2
- UDP-N-acetylglucosamine transporter ROCK1
- Mitochondrial arginine transporter BAC2
- Mitochondrial phosphate carrier protein 3, mitochondrial
Sequence:
MADSLAPLLPTHIEEDEDTSSPLTFDKILEKSLSDFGFSQFLQIVLVGLALTFDSQQIFITVFTDAYPTWHCLDHTICNPATTDICKIPRSAWDWDGGFKGKSVISEFDLECSSSFLRSLPSSTFYVGSIVGGVVLAMIPDGSLGRKQLLFFSSFAMSLTGISIFLSSNIWIYSFLKFVIGFARSQTGTYALVLISERISTKWRPRATMVPFTLFVLGFMSLSGIAYLVRHASWKVLYLCTSIPAGIHSIFIYFFALESPRWLHLEGKNKEAIEVLKRISPANRGYLESVSSRLRPKETLEQTSSYSIKDLFIIKWAFRRVTLVMIIMFGLGMSYYGVPLAVRDIKVNIYMSEALNAMVELPTFVVTPILLEQFSRRSSVLVNCLIGGASGVLCFVMSLYGRTKIAFALELGSFFCARIGFNLMAIYLVELFPTCVRNSATMMLRQALVVGGACCPLIASLGRNVPSLSFAVFGFAMSGLGLFALLLPETKGLSLCDTMEEQEQRDQALKTSHSC
Protein: Patched family protein (F4JTN1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- Transcription factor bHLH27
- Transcription factor bHLH35
- At5g17540
- Cytochrome P450 76C3
- Cytochrome P450 76C1
- Cytochrome P450 76C4
- Cytochrome P450 76C2
- Phosphomethylpyrimidine synthase, chloroplastic
- Cytochrome P450, family 76, subfamily C, polypeptide 5
- Cytochrome P450 monooxygenase-like protein
Sequence:
MAIPTKLLLLQLFTFSLLLTANLTHSEPSNNRHSKEYCAMYDICGHRSDGKVLNCPYASPSIQPDELFSAKIQSLCPTISGNVCCTETQFDTLRSQVQQAVPFLVGCPACLRNFLNLFCELSCSPNQSLFINVTSVAEVSGNLTVDGIDYHITDTFGEGLYESCKEVKFGTMNTRAINFVGGGAKNFREWFTFIGQKAPSGFPGSPYAINFKSSIPESSAMVPMNVSVYSCGDTSLGCSCGDCPSSPACSSPEPLPPHDEDSCSIRIGPLKVRCIELSMALVYVLLVSCFFGWAGLNRRRNTTQPLDSSKPLLHPVEEDGINSEMKENILGVKVQRHAQLSPVQRYMAKFYRSYGSWIARNPSLVLFMSVAIVLALCSGLYNFKVETRPEKLWVGPESKAAEEKKFFDTHLSPFYRIEQLILATVPDPKSGRAPSIVTDENILLLFDIQQKVDQIRGNYSGSEVSLPDICLKPLGEDCATQSILQYFKMDSGTFDDYGGVEHAEYCFQHYTSSETCLSAFQAPVDPSAVLGGFSGNNYSEVMVSELGCSVPFDCYSDVKRTLFQATAFVVTYPVNNVIGDSSNENARAVAWEKSFIQLAKEELLPMVRSKNLSLSFSSESSIEEELKRESTADVITIAASYLVMFVYISVTLGDAPQFYTFYISSKVLLGLSGVVLVLLSVLGSVGVFSALGVKSTLIIMEVIPFLVLAVGVDNMCILVHAVKRQPREVSLEQRISSALVEVGPSITLASLSEVLAFAVGAFVPMPACRIFSMFAALAIMLDFFLQITAFVALIVFDCKRSADNRIDCFPCIKVPSSSRESVEGGREPGFLERYMKEVHAPVLGLWGVKMVVVAVFFAFALASIAISPRLETGLEQKIVLPRDSYLQDYFDSLSEYLRVGPPLYFVVKNYNYSSESRHTNQLCSISQCNSNSLLNEISRASQASDTSYIAKPAASWLDDFLVWLSPEAFGCCRKFTNGSYCPPDDQPPCCTAEEDICSLDGICKDCTTCFRHSDLVQDRPSTAQFREKLPWFLNALPSADCAKGGHGAYTNSVDLKGYESGVIQASEFRTYHTPLNTQGDYVNALRAAREFSSRISNSLKIDIFPYSVFYIFFEQYLNIWTVALTNLAIAIGAIFIVCWLITSSAWSSAIIVLVLVMILVDLMGMMVILGIQLNAVSVVNLIMSIGIAVEFCVHISHAFLMSSGDREHRAREALETMGASVFSGITLTKLVGVIVLCFARSEIFVVYYFQMYLALVIIGFLHGLVFLPVILSLAGPPQLNLDIEQQQTDEASSSLLN
Protein: AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma-adaptin 3b) (Sigma2-adaptin) (P62744)
Organism: Rattus norvegicus (Rat)
Function: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P63010}. Membrane, coated pit {ECO:0000250|UniProtKB:P53680}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53680}; Cytoplasmic side {ECO:0000250|UniProtKB:P53680}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250|UniProtKB:P63010}.
Interaction partners:
- AP-2 complex subunit alpha
- AP-2 complex subunit beta
- AP-2 complex subunit mu
- AP-2 complex subunit alpha-2
- Intersectin 2
- Clathrin heavy chain 1
- AP2-associated protein kinase 1
- F-BAR domain only protein 2
- Clathrin light chain A
- Adaptin ear-binding coat-associated protein 2
Sequence:
MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE
Protein: Lymphocyte antigen 6 complex locus protein G6d (Protein Ly6-D) (Megakaryocyte-enhanced gene transcript 1 protein) (O95868)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000269|PubMed:17008713}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17008713}. Cell projection, filopodium {ECO:0000269|PubMed:17008713}.
Interaction partners:
- Lymphocyte antigen 6 complex locus protein G6f
- Lymphocyte antigen 6 complex locus protein G6c
Sequence:
MKPQFVGILLSSLLGAALGNRMRCYNCGGSPSSSCKEAVTTCGEGRPQPGLEQIKLPGNPPVTLIHQHPACVAAHHCNQVETESVGDVTYPAHRDCYLGDLCNSAVASHVAPAGILAAAATALTCLLPGLWSG