wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized membrane protein C1322.03 (O94543)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi apparatus membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized membrane protein C663.14c
- TRP-like ion channel pkd2
- Stretch-activated cation channel yam8
- Vacuolar calcium ion transporter
- Uncharacterized serine-rich protein C1E8.05
- Calcium-channel protein cch1
Sequence:
MKPRPYSVFLFLHIVFYSLLSAVNGSPSLDYFETCSNFVPRAGIPTFSPYAVIKNFDEVNRMYYIQVVGNLSGVITIVGGNGSHIHAASVYSETYALGKLVTSNTTKLCDVVMDPHSFEVPIKCPWAAGSAAFMVKVPFKSTLSDYSKYELTTLTTRVIVVDGTPEKNVITCMKFGLSTTLYYFYPVISYLVVVSLAYVSFSIIYALFLNPWTGSLDPFKSIFNFNMDPDALRLTSLGFFDFVQYLQFAVSTAQVSVMFPKFYINIMAALSWGTALFRFPIFSEPAEYQFADFADLSVASSSYADYLPKSYGMYSFLDSIGIGTACWLPFLIVMVIYLFAALFVALLVIFLKWLMSRIFNETIAETRWDTWSFIAGSLIRLYFLTYFPTVAYMSFQFVAPPTGYEIIPVLWFIFFGIFIPVYLYMNLAFVEPSSKLLEDQTYLHLFGSIYNSFREERVMFWIFPIAVQFMRGITVGVIGSSGSAQLAIFFILEVANVVAYAYVRPHFPQTSMNTLNTFISTMRLITVILMIPLDPRLKVLGISRDLLAYAILFIHIMVCILFLLLSTQRFMEVSARLLGAKSESKGVPLDRPFGWARVFGINELRRRRLKDPYSNGNTMMFDHSTYNSNEMSVPLTPVSVCSNSLKKDGEAAPPKLFVQTNCIPPVTQASSLVPSKNNTASSSSLMLDSPVTPSSPYSTSQGYSFYRPPKPKSSVRKRDMDQLRALQLDFLNNKPNLLRHDVNYAVREADVYHPHVDTSIDSLSQISSQPFEMRPTAIPPPPKNAFQRAWQIVQSTAKSIWHSDPPKESEKGFVVLRSRPRPNLQKPLPQLHIEPSRDEQYSMERKKTDDSLAESAWSIPHP
Protein: Uncharacterized protein (Q384I2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSDSHHSGYDENSGRGNAQKRPRSESTHGSSNSWQIVSSSRCIACGRLRSLCECRSLRVDPELRRKNLDTLLLNTPYVRCKQLKALDEAGREEERHRRCIAEEWYSKMRIIKRAAHTDKYLLRVTLDEVRGRENLSALERKEWVEGMALSDKYMVLLALVQREREERLKFYASAERATRMLGTWHNTVFHLLGLQSREVAFRRTLVNNEAAARASLLSIELEALKVMENNEKSRLEFFELFWASRESVADAWMQGVEALECAMAETVQNLEKCFQERTRCFEIVLKRRDELLLEEENARQRLHSLFEEENDFLEENMRFFQQRRAAVMQQEASARGVICQEATDAYSALFLECRRDREKACEAESFKRRRREEEFHAAVASLQDIMKEEEAALALLKTQEHHERELRYQWMLEREKAIISAENTLLQHVQLLFSEEEKARGAIVHLMQQQEAETASWLRHKERKLREIIETALEEKSQMLLLEHEERFSLVSQKAEHEDAVRRWVDHKESARQSLATAETTHRNRWVDMERNAREELSWRFGEGLETCYSQVQQRMEALTKLQQRAFHAKEGIVKQEEEALRLLLGTLRDDEERSLREEIHRRVVDILNTETEHRSHLTQQEVGNRESITTMFLMQERFFKKEAQELLKAQLYEIVAAEESHRRVLLQDADDSVERLYHSYKKLLEEARRREEERVREERRQREVALLEDPRLYREEEDCDLCVDGASPPTGLDDGCYNDMKMGPLGETWMLQRQHVVEDLGGESADVVLLTHETTAFLFSIVNAITEREAILAAERTKAESTMKNIQKKIERQKSVFANVKEQLEESQEKLKRDAENHSKRLATQREAQQKLEAQLARERTRLKEKTEELQRTKNSVSEMRDSIHSQYKKR
Protein: Probable membrane protein (P71787)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Probable sugar transferase
- Probable conserved transmembrane protein
- Uncharacterized protein Rv1510
Sequence:
MIPVMSARFTGFPLLPVALRHGITSGRGCGFILDVGAQRPFGNDVLLSVATRKIRSRLPGDRVGNHGALLPFRAEPRRIQMKRPPEVLRGAVTASRERLWAIGSQSERTLMLGTILLASVISAATAYALSQWYAVDVFSTLLVVPGDCWLDWGMNIGRHCFSDYAMVAAAGIQPNPADYLISLPADYQPTAVAAWAPARIPYAIFGLPSHWLGAPRLGLICYLVALTMAVISPAIWAARGARGLERVVIFVTLGAAAIPAWGVIDRGNSTGFVVPIALAYFVALSRQRWGLATITVILAVLVKPQFVVLGVVLLAARQWRWAGIGITGVVVSNIAAFLLWPRGFPGTIAQSIHGIIKFNSSFGGLRDPRNVSFGKALLLIPDSIKNYQSGKIPEGFLTGPRTQIGFAVLVIVVVAVLALGRRIPPVMVGIVLLATATFSPADVAFYYLVFVLPIAALVARDPNGPPGAGIFDQLAAHGDRRRAVGVCVSLAVALSIVNVAVPGQPFYVPLYGQLGAKGVVGTTPLVFTTVTWAPFLWLVTCVVIIVSYARKPARPHDSHNGPTRESDQDTAASTTSCLPNPVEESSPRGPGPICQNYTP
Protein: Uncharacterized protein C297.06c (Q9UUN3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Chorismate synthase
- Rpb7-binding protein seb1
- Small ribosomal subunit protein eS4A
Sequence:
MQGKINYKDITQKEMFNEIFKEYVKEEKQIDLGTCDQDSVHDLWRRFVKRWNDGKMKSKWYSLGKRISQPSYARLVGPSRPTLENLQDRRELQEQLNELRKLSRKSAFKSQAKRETELLDEILPKEPAGSKEAMQQKKKEKRAALKHYREASDNEEDLKETDLYGDRDSFQSRLKQKKQRSEFRASKREMERLERDQELRNKIEERNKKELETIEKLRELAKARLQGFSS
Protein: Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial (AtP5CDH) (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 12 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) (Q8VZC3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in the inhibition of programmed cell death by converting the toxic proline catabolism intermediate (s)-1-pyrroline-5-carboxylate (P5C) to glutamate.
Subcellular location: Mitochondrion matrix {ECO:0000305|PubMed:11532180}.
Interaction partners:
- Delta-1-pyrroline-5-carboxylate synthase B
- Ornithine aminotransferase, mitochondrial
- Proline dehydrogenase 1, mitochondrial
- Delta-1-pyrroline-5-carboxylate synthase A
- Proline dehydrogenase 2, mitochondrial
- Pyrroline-5-carboxylate reductase
- Glutamate decarboxylase 5
- Glutamate decarboxylase 2
- Probable inactive poly [ADP-ribose] polymerase SRO5
- Glutamate decarboxylase 3
Sequence:
MYRVFASRALRAKSLCDKSSTSLASLTLSRLNHSIPFATVDAEELSGAHPAEVQSFVQGKWIGSSNHNTLLDPLNGEPFIKVAEVDESGTQPFVDSLSQCPKHGLHNPFKSPERYLLYGDISTKAAHMLALPKVADFFARLIQRVAPKSYQQAAGEVFVTRKFLENFCGDQVRFLARSFAIPGNHLGQQSHGYRWPYGPVTIVTPFNFPLEIPLLQLMGALYMGNKPLLKVDSKVSIVMEQMMRLLHYCGLPAEDVDFINSDGKTMNKILLEANPRMTLFTGSSRVAEKLALDLKGRIRLEDAGFDWKVLGPDVQEVDYVAWQCDQDAYACSGQKCSAQSMLFVHENWSKTPLVSKLKELAERRKLEDLTIGPVLTFTTEAMLEHMENLLQIPGSKLLFGGKELKNHSIPSIYGALEPTAVYVPIEEILKDNKTYELVTKEIFGPFQIVTEYKKDQLPLVLEALERMHAHLTAAVVSNDPIFLQEVIGNSVNGTTYAGLRGRTTGAPQNHWFGPAGDPRGAGIGTPEAIKLVWSCHREVIYDYGPVPQGWELPPST
Protein: POM121 and ZP3 fusion (C9J370)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVCSPVTLRIAPPDRRFSRSAIPEQIISSTLSSPSSNAPDPCAKETVLSALKEKKKKRTVEEEDQIFLDGQENKRRPSLSLSPRLVQWCNFGSLHPLPPRFKRFSCLSLPSRWITGVHCCTQLIFVFLVETRFHHVCQASLELLTSSDPPTLASQSAGIMGVSHGARPTCLALTPFCFLPSCLVDGLTDASSAFKVPRPGPDTLQFTVDVFHFANDSRNMIYITCHLKVTLAEQDPDELNKACSFSKPSN
Protein: GATA zinc finger protein (Q5BPJ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 30-kDa cleavage and polyadenylation specificity factor 30
- Cleavage and polyadenylation specificity factor subunit 1
- Cleavage and polyadenylation specificity factor subunit 3-I
- Cleavage and polyadenylation specificity factor subunit 2
- Nucleolin 1
- 18S rRNA
- Small ribosomal subunit protein uS9c
Sequence:
MRPPYNSFQPQARPYRPQHQLQQQQQINGFSNHQQQQHNGYQNPMNANQLGMMNPQMMNNPMMGHNMPMPNMPIHPQFFNNMPQQLPQFAMPNHINQLLPNLLGNLQFAVANSNLMGHSLPNFFQPSLEPHAFSSRPQLNSFNSLPYPPVPNPHQNHQSGPPGFSEPRPQGQSVDNTNGSGPNGNDFRNKFPKHQNFKGPGQGFQRPQLHQADNGKRKSGFNKDHRGKGNNNKMKTGLDGSDTGNIAKEKKRSYALMYTPREVQQWREARRKNYPTKFLVEKKVKKNVSASILDEEAKMRRQQLREVLAKQAELGVEVAEVPSHYLSNNDEQVNGDRGNNNGRKGRFQNNRRNKRRHDRKDKFDNKKPRLEDKKSSQDSSITTRKPTLLEKLLSADIKRDKSQLLQVFRFMVMNSLLKEFPEQPLKLPLITVKETGCEDAMEDPSIEGLCDGLSDGDDVDGDDSSCDEDV
Protein: Thymosin beta-4, Y-chromosomal (O14604)
Organism: Homo sapiens (Human)
Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 9Y
- Histone demethylase UTY demethylase UTY)
- Lysine-specific demethylase 5D
- Thymosin beta-4
- Zinc finger Y-chromosomal protein
- ATP-dependent RNA helicase DDX3Y
- Actin, cytoplasmic 1
- Actin, cytoplasmic 2
- Eukaryotic translation initiation factor 1A, Y-chromosomal
- Small ribosomal subunit protein eS4, Y isoform 1
Sequence:
MSDKPGMAEIEKFDKSKLKKTETQEKNPLSSKETIEQERQAGES
Protein: Suppressor of fused homolog (Q8QG94)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR011844}. Nucleus {ECO:0000256|PIRNR:PIRNR011844}.
Interaction partners:
- Zinc finger protein GLI1
- Zinc finger protein GLI2
- Transcriptional activator GLI3
- Protein kinase domain-containing protein
- Kinesin family member 7
- Speckle type BTB/POZ protein
- Protein smoothened
- Speckle type BTB/POZ protein like
- cAMP-dependent protein kinase
- Cullin 3
Sequence:
MEGTRPGGAAPAGGAGSGSGSGSSSFPSLFPPGLHGIYGECRRLYPEQPNPLQVTAILKYWLGGPDPLDYVSMYRNIGNPALNVPEHWHYVSFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHAAQQWNGQGILELLRTVPVAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINAQRQNGLNHDRAPSRKDSLESESSAAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDTAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVERMLEDLEDLNSPEEFKLPKEYSWPEKKLKVSILPDAVFDNPLH
Protein: Dickkopf-related protein 4 (Dickkopf-4) (Dkk-4) (Q8VEJ3)
Organism: Mus musculus (Mouse)
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
- Low-density lipoprotein receptor-related protein 6
- Kremen protein 1
- Dickkopf-related protein 1
- Dickkopf-related protein 2
- Protein Wnt-2
- Kremen protein 2
- Protein Wnt-3a
- Protein Wnt-6
- Protein Wnt-10b
Sequence:
MVLVTLLGLSWFCSPLAALVLDFNNIKSSADVQGAGKGSLCASDRDCSEGKFCLAFHDERSFCATCRRVRRRCQRSAVCCPGTVCVNDVCTAVEDTRPVMDRNTDGQDGAYAEGTTKWPAEENRPQGKPSTKKSQSSKGQEGESCLRTSDCGPGLCCARHFWTKICKPVLREGQVCSRRGHKDTAQAPEIFQRCDCGPGLTCRSQVTSNRQHSRLRVCQRI
Protein: Cyclin-dependent kinase 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Protein kinase 5) (PfPK5) (cdc2-related kinase 2) (P61075)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Serine/threonine-protein kinase. Involved in the control of the cell cycle (By similarity). Required for entry into S-phase and mitosis (By similarity). Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. In schizonts, phosphorylates ORC1 resulting in its dissociation from DNA, relocalization to the cytoplasm and likely its degradation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P04551}.
Interaction partners:
- Oocyst capsule protein
- Cell division cycle protein 20 homolog, putative
- Cyclin-dependent kinases regulatory subunit
- ATPase AAA-type core domain-containing protein
- Cyclin 1
- Cyclin-dependent kinase 2 homolog
- Origin recognition complex subunit 2
- Origin recognition complex subunit 1
- Kinesin-5
- Cyclin
Sequence:
MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKENN
Protein: Pentatricopeptide repeat-containing protein At4g31850, chloroplastic (Protein PROTON GRADIENT REGULATION 3) (Q9SZ52)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in the stabilization of the primary polycistronic transcript of the petL operon encoding subunits of the cytochrome b6-f complex.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- NAD
- Cytochrome b6-f complex subunit 6
- Pentatricopeptide repeat-containing protein At2g17033
- Photosystem I reaction center subunit IX
- Cytosolic sulfotransferase 1
- ATP synthase subunit c, chloroplastic
- Protein high chlorophyll fluorescent 107
- At1g22850/F29G20_19
- WAT1-related protein At4g16620
- AT3g09210/F3L24_8
Sequence:
MVALLCSASLCGDISVGDACLVSNIKAKCRDNLVTGGLKFHALKIGSRKKHWRRKSMRCSVVSMKSSDFSGSMIRKSSKPDLSSSEEVTRGLKSFPDTDSSFSYFKSVAGNLNLVHTTETCNYMLEALRVDGKLEEMAYVFDLMQKRIIKRDTNTYLTIFKSLSVKGGLKQAPYALRKMREFGFVLNAYSYNGLIHLLLKSRFCTEAMEVYRRMILEGFRPSLQTYSSLMVGLGKRRDIDSVMGLLKEMETLGLKPNVYTFTICIRVLGRAGKINEAYEILKRMDDEGCGPDVVTYTVLIDALCTARKLDCAKEVFEKMKTGRHKPDRVTYITLLDRFSDNRDLDSVKQFWSEMEKDGHVPDVVTFTILVDALCKAGNFGEAFDTLDVMRDQGILPNLHTYNTLICGLLRVHRLDDALELFGNMESLGVKPTAYTYIVFIDYYGKSGDSVSALETFEKMKTKGIAPNIVACNASLYSLAKAGRDREAKQIFYGLKDIGLVPDSVTYNMMMKCYSKVGEIDEAIKLLSEMMENGCEPDVIVVNSLINTLYKADRVDEAWKMFMRMKEMKLKPTVVTYNTLLAGLGKNGKIQEAIELFEGMVQKGCPPNTITFNTLFDCLCKNDEVTLALKMLFKMMDMGCVPDVFTYNTIIFGLVKNGQVKEAMCFFHQMKKLVYPDFVTLCTLLPGVVKASLIEDAYKIITNFLYNCADQPANLFWEDLIGSILAEAGIDNAVSFSERLVANGICRDGDSILVPIIRYSCKHNNVSGARTLFEKFTKDLGVQPKLPTYNLLIGGLLEADMIEIAQDVFLQVKSTGCIPDVATYNFLLDAYGKSGKIDELFELYKEMSTHECEANTITHNIVISGLVKAGNVDDALDLYYDLMSDRDFSPTACTYGPLIDGLSKSGRLYEAKQLFEGMLDYGCRPNCAIYNILINGFGKAGEADAACALFKRMVKEGVRPDLKTYSVLVDCLCMVGRVDEGLHYFKELKESGLNPDVVCYNLIINGLGKSHRLEEALVLFNEMKTSRGITPDLYTYNSLILNLGIAGMVEEAGKIYNEIQRAGLEPNVFTFNALIRGYSLSGKPEHAYAVYQTMVTGGFSPNTGTYEQLPNRA
Protein: Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain] (O09107)
Organism: Mus musculus (Mouse)
Function: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Relaxin receptor 2
- Relaxin receptor 1
- Relaxin-3 receptor 1
- Prorelaxin 1
- Relaxin-3
- Relaxin-3 receptor 2
- Insulin-like peptide INSL5
- Steroid 17-alpha-hydroxylase/17,20 lyase
- 17-beta-hydroxysteroid dehydrogenase type 3
- Steroidogenic acute regulatory protein, mitochondrial
Sequence:
MRAPLLLMLLALGSALRSPQPPEARAKLCGHHLVRTLVRVCGGPRWSPEATQPVETRDRELLQWLEQRHLLHALVADVDPALDPQLPRQASQRQRRSAATNAVHRCCLTGCTQQDLLGLCPH
Protein: Transcription factor SOX-4 (Q06831)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression. Involved in skeletal myoblast differentiation by promoting gene expression of CALD1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q06945}.
Interaction partners:
- POU domain, class 5, transcription factor 1
- Catenin beta-1
- Lymphoid enhancer-binding factor 1
- Histone-lysine N-methyltransferase EZH2
- Transcription factor 7-like 1
- Trans-acting T-cell-specific transcription factor GATA-3
- Transcription factor 7-like 2
- Sulfhydryl oxidase 1
- Transcription factor 7
Sequence:
MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIQEAERLRLKHMADYPDYKYRPRKKVKSGNAGAGSAATAKPGEKGDKVAGSSGHAGSSHAGGGAGGSSKPAPKKSCGPKVAGSSVGKPHAKLVPAGGSKAAASFSPEQAALLPLGEPTAVYKVRTPSAATPAASSSPSSALATPAKHPADKKVKRVYLFGSLGASASPVGGLGASADPSDPLGLYEDGGPGCSPDGRSLSGRSSAASSPAASRSPADHRGYASLRAASPAPSSAPSHASSSLSSSSSSSSGSSSSDDEFEDDLLDLNPSSNFESMSLGSFSSSSALDRDLDFNFEPGSGSHFEFPDYCTPEVSEMISGDWLESSISNLVFTY
Protein: Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) (Q8NEV8)
Organism: Homo sapiens (Human)
Function: May act as Rab effector protein and play a role in vesicle trafficking.
Interaction partners:
- Ras-related protein Rab-27A
- Melanophilin
- Ras-related protein Rab-27B
Sequence:
MTKVPPAFDFSFLNDEEARKILQVLERNEELQRAEKDRISKLQKTKRDIRWLQGVTGEWFEEIQRKKFCNETDVSQMLKQPLTYRLSKEMAKNDPIELPTSRSKNVTNQKKPTPFSSRMSFRSSFASLFSFRKSGKETSKLPSLGQKGCDGHAGPPMPVRGAAVQAKIYNSPLENHLVDSTFVPKPAVMREESGMPPPWDASLLENEFFQVLDDLDSKLAQEQSASSVNTRTPLNYGSRTQFGHFYSSGNRHGNITERHKKHYNETSNMSIYDILRPGTPREGFKTFSPRTSTIYDMYRTREPRVFKEDYVQKNTFGSTSLCFDSRQRSALPATGHFTARSLHFPATTQSKSGFIPPRHQQSPKRTPLSSIIWNRSDSSRDRENQEEFLRAPSPMEIDPADKYVYPRGFQENKRYESYHSQNVYQRVSLNAPMENAMSPDTFENSENMPFYHQSNTFTRSFFSNTFGRSGEQRRFGQGPFWGQEKGHSFWSDFHRSRKSFSSSDRDFEMISMEANSVSAIHGHNVSSEHWESFSSGYGTDVSRGQEEPHPWQFDFQRSTLDSMVVSHGNETQLTPHFGTPNVCSMTGSSYHVKSSELVSQQDSSPVEVHINKEASSFGIAQTLASSFKTSFSQISDDRRNPQSPNLQNPTVTLQKIFPNKPASHPMRSHTEVTVTSSNSVDSLPLAKSQPNILVTEVNNEKDLNESISEEDKQLSKMDQTNKAGEIPQPVSQTGISNSLPDFQNPLSQDSAKSNGFGFNASTIISSKKSPRVFSRKDTSKMYIPHTDKSNDIKQDKRFTENRKLGSTASLPFIQEHRTPPSFPRTDQGCHQELTVNNEDISRIITNNHWSSALTDTQNAQYSKCKLTPGHKTSCDSLDLSSAALPDSSPSKNSSLDAPVVPSTTVFSRRSPSDKDPSLGEREEKDNAGKNQKNQFIVSHSENQERNDSPVPTHDEVVDVKCHSHSPFRNERGKGKIRHHISCIEKLSKTESISVPTSDHRSLIEANQSNSKVSELDTIYCTLPRKSSSFLIHGRQSGSKIMAASLRNGPPPFQIKNNVEDAMGNYMLNKFSPSSPESANECSKVLSDSALEAPEATERMTNVKSSGSTSVRKGPLPFLINRAMSCPSGEPHASTGREGRKKPLTSGMDASELTPRAWERIISPVESDSSVRDCSLTKRQHQKENFQEYTEKEGKMAASRRSVFALSNEDPLPFCSDLSGKERGKTLHKVKTTSTFSVSGDEDNVKCLEVVSIYYTLPRKPSKKFCNLLQQYTQNTNLLIESPQVETETFPNALEKDKQNYSTREQSGTPSCENLKMSVNSDQTLTTENMTAFRLSNRGPLAPTLQEMASVEAAVSLPEEESKAREIFSDNLAKTPLGDSENKKERGKKLQSETLHTSLMLQRKNVSEEKSENCQQSINSSNSGPSSLPALSEVNIGNSQTRRSSWECTGSGRAIPFTGSGKCPQKDHTSTAVGDGSSGSQPREGRGDIGTNCQKMTNKTLSHSESQVFALTPALHKLQLGEETQSDEPNLESLQSEPRELPQRSQEANMTESRKAEDEMQKSAWDQPSLPEGNKNKTNLDDLVKGENRSSVKHRLAAMSKASRKFPAKDVSPRRHVATIFPQSGSRSGFDHLSLGTVECNPLFPEPTPKSAESIGESRLSENGKHVKKSENLLPITVLPNREPSTHVSNQKSNSISQRHQNEFKNVSESPSKHENSKDVTAAQNLVRESGAPSPITFTSLREAEFSDNQRRLSPPFPLEPAQKSRVSSPLASFLQQQRSASSLEWEPEPHLYRSKSLKSINVHGDLLRKSHPPKVRERHFSESTSIDNALSRLTLGNEFSVNNGYSRRFRSFSELPSCDGNESWAYRSGTKTGPRSAISIYRPIDYGIFGKEQQLAFLENVKRSLTQGRLWKPSFLKNPGFLKDDLRNPPNPSESLSSNSPSSQVPEDGLSPSEPLNIYEDDPVDSDCDTDTTTDDEYYLDENDKESEL
Protein: Cytochrome P450 monooxygenase gsfF (EC 1.-.-.-) (Griseofulvin synthesis protein F) (D7PI20)
Organism: Penicillium aethiopicum
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections. The first step of the pathway is the formation of the heptaketide backbone by gsfA which is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units. The resulting benzophenone can undergo a spontaneous dehydration to form norlichexanthone. However, the true precursor for the griseofulvin biosynthesis is not norlichexanthone, but the heptaketide benzophenone that is O-methylated at 3-OH by gsfB to produce griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C. Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B. The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin. Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin.
Interaction partners:
Sequence:
MTVLFILSAGLVAVFGYLVSWFIYCRTLHPLSKVPGPFWPSVTRLWLTYAVSRGELDVVQRDLHRRYGPLVRIAPDEIACADPEAIRKIYSTTSPLNKSDFYHIWDVGAFSKYPNAFAIVDENMHFERRRIVSSVYSMSTVLTLEPYIDNCSRLFVKRMTERTVPHEAIDLGDWFLWYAYDVIGELFFGHSLGFIENRGDEGGFLASLEVMLPVLTIAAASSPLVRGLIMGLFTLSSTARKGLKGMNHIIETARASVDKRASAVAEPGKGERKDLLHNLLNIVSSKGDKLDFGIEDVKNEAFAALTAGADATMIELQAIFYYLVKDRSVYEELRKEVDQAVETGKLSEFPSYSEVVQLPLLKATIKEALRLHPAVGFTMPRVVGQAGIELLGMYIPPGWKVGMNAAVVGRDEGVYGTDANTFRPERWIERTDSDMDRCNNLVFGAGTRTCIGKQIALSEIYKMVPLLIRKFDFALVDPSKSWTTHDYFFNKQSGVQVKVTVRGL
Protein: Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C) (A5D8V6)
Organism: Homo sapiens (Human)
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular location: Late endosome membrane {ECO:0000305|PubMed:15509564}; Peripheral membrane protein {ECO:0000305|PubMed:15509564}. Note=Probably associates with membranes. Recruited to the plasma membrane by HIV-1.
Interaction partners:
- Vacuolar protein sorting-associated protein 28 homolog
- Tumor susceptibility gene 101 protein
- Multivesicular body subunit 12A
- Multivesicular body subunit 12B
- Vacuolar protein-sorting-associated protein 36
- Vacuolar-sorting protein SNF8
- Ubiquitin-associated protein 1
- Charged multivesicular body protein 2a
- Vacuolar protein-sorting-associated protein 25
- Charged multivesicular body protein 6
Sequence:
METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPYGFPPPPGPAWPGY
Protein: Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) (Q86V21)
Organism: Homo sapiens (Human)
Function: Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JMI1}.
Interaction partners:
- Hydroxymethylglutaryl-CoA lyase, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Acetyl-CoA acetyltransferase, cytosolic
- Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
- Peroxisomal bifunctional enzyme
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
- Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
- Dehydrogenase/reductase SDR family member 6
Sequence:
MSKEERPGREEILECQVMWEPDSKKNTQMDRFRAAVGAACGLALESYDDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLRHKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLATGAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKAVEQGGAFSNPETLDLYRDIPELQGF
Protein: CCN family member 5 (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58) (WNT1-inducible-signaling pathway protein 2) (WISP-2) (O76076)
Organism: Homo sapiens (Human)
Function: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Proto-oncogene Wnt-1
Sequence:
MRGTPKTHLLAFSLLCLLSKVRTQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF
Protein: Pectin acetylesterase (EC 3.1.1.6) (E0SDD1)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Interaction partners:
- NADH-quinone oxidoreductase subunit C/D
Sequence:
MSLRRVIAGTLMMSVSGFTLADTIFPIWPQGEAPGAATSSVQQQVVERSKDPTLPDRAVTGIRSPEITVYTPEKPNGTALLITPGGSYQRVVLDKEGSDLAPFFTRQGYTLFVMTYRMPGDGHQEGADAPLADAQRAIRTLRAHAAQWQIDPQRIGIMGFSAGGHVAASLGTRFAQTVYPAQDEIDHISARPDFMVLMYPVISMQENIAHAGSRKALIGSHPSDAQIQRYSAEKQVSAQTPPTFLVHAIDDPSVSVDNSLVMLAALRAHQIPAEIHLFEQGKHGFGIRGTVGLPAAIWPQLLDNWLTSLPLKKNTANQPDKK
Protein: Pyridoxamine 5'-phosphate oxidase homolog (PNP/PMP oxidase homolog) (PNPOx homolog) (Q06608)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MAWTSTLPAHLLNLIKNSKYVHVATCSKDCIPSVALMNYIYVPGEKLFGQTDNKNDYIIFVSPQDTQKFYNIKENPKVALLFHDWIIANNLSVGKESISGTPTPTSIPHEEQRQSELLNLLQELNQAELNQMSASIGGETEIVNPESEESKYYKDLILKANPDAKAFIFEKNTAVVKVRIDNARVSNNENRTMFLSKGKS