Protein: Envelopment polyprotein (M polyprotein) [Cleaved into: Mucin-like variable region; GP38; Glycoprotein N (Gn) (37 kDa protein) (Glycoprotein G2); Non-Structural protein M (NSm) (15 kDa protein); Glycoprotein C (Gc) (75 kDa protein) (Glycoprotein G1)] (Q8JSZ3)
Organism: Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV)
Function: Glycoprotein N and glycoprotein C interact with each other and are present at the surface of the virion (Probable). Glycoprotein N probably locks the Gn-Gc complex in a prefusion state. Glycoprotein N and glycoprotein C are able to attach the virion to host cell receptors (Probable). This attachment induces virion internalization predominantly through clathrin-dependent endocytosis.
Subcellular location: [Envelopment polyprotein]: Host endoplasmic reticulum membrane {ECO:0000269|Ref.2}.; SUBCELLULAR LOCATION: [Glycoprotein N]: Virion membrane {ECO:0000305|PubMed:12072526}; Multi-pass membrane protein {ECO:0000305}. Host Golgi apparatus membrane {ECO:0000269|PubMed:15850490}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Glycoprotein C]: Virion membrane {ECO:0000305|PubMed:12072526}; Single-pass type I membrane protein {ECO:0000305}. Host Golgi apparatus membrane {ECO:0000269|PubMed:15850490}; Single-pass type I membrane protein {ECO:0000305}. Host endoplasmic reticulum membrane {ECO:0000269|PubMed:15850490}; Single-pass type I membrane protein {ECO:0000305}. Note=Interaction between glycoprotein C and glycoprotein N is essential for proper targeting of glycoprotein C to the Golgi complex, where virion budding occurs. {ECO:0000269|PubMed:15850490}.; SUBCELLULAR LOCATION: [Non-Structural protein M]: Host Golgi apparatus membrane {ECO:0000269|PubMed:17409136}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MHISLMYAILCLQLCGLGETHGSHNETRHNKTDTMTTPGDNPSSEPPVSTALSITLDPSTVTPTTPASGLEGSGEVYTSPPITTGSLPLSETTPELPVTTGTDTLSAGDVDPSTQTAGGTSAPTVRTSLPNSPSTPSTPQDTHHPVRNLLSVTSPGPDETSTPSGTGKESSATSSPHPVSNRPPTPPATAQGPTENDSHNATEHPESLTQSATPGLMTSPTQIVHPQSATPITVQDTHPSPTNRSKRNLKMEIILTLSQGLKKYYGKILRLLQLTLEEDTEGLLEWCKRNLGLDCDDTFFQKRIEEFFITGEGHFNEVLQFRTPGTLSTTESTPAGLPTAEPFKSYFAKGFLSIDSGYYSAKCYSGTSNSGLQLINITRHSTRIVDTPGPKITNLKTINCINLKASIFKEHREVEINVLLPQVAVNLSNCHVVIKSHVCDYSLDIDGAVRLPHIYHEGVFIPGTYKIVIDKKNKLNDRCTLFTDCVIKGREVRKGQSVLRQYKTEIRIGKASTGSRRLLSEEPSDDCISRTQLLRTETAEIHGDNYGGPGDKITICNGSTIVDQRLGSELGCYTINRVRSFKLCENSATGKNCEIDSVPVKCRQGYCLRITQEGRGHVKLSRGSEVVLDACDTSCEIMIPKGTGDILVDCSGGQQHFLKDNLIDLGCPKIPLLGKMAIYICRMSNHPKTTMAFLFWFSFGYVITCILCKAIFYLLIIVGTLGKRLKQYRELKPQTCTICETTPVNAIDAEMHDLNCSYNICPYCASRLTSDGLARHVIQCPKRKEKVEETELYLNLERIPWVVRKLLQVSESTGVALKRSSWLIVLLVLFTVSLSPVQSAPIGQGKTIEAYRAREGYTSICLFVLGSILFIVSCLMKGLVDSVGNSFFPGLSICKTCSISSINGFEIESHKCYCSLFCCPYCRHCSTDKEIHKLHLSICKKRKKGSNVMLAVCKLMCFRATMEVSNRALFIRSIINTTFVLCILILAVCVVSTSAVEMENLPAGTWEREEDLTNFCHQECQVTETECLCPYEALVLRKPLFLDSTAKGMKNLLNSTSLETSLSIEAPWGAINVQSTYKPTVSTANIALSWSSVEHRGNKILVSGRSESIMKLEERTGISWDLGVEDASESKLLTVSVMDLSQMYSPVFEYLSGDRQVGEWPKATCTGDCPERCGCTSSTCLHKEWPHSRNWRCNPTWCWGVGTGCTCCGLDVKDLFTDYMFVKWKVEYIKTEAIVCVELTSQERQCSLIEAGTRFNLGPVTITLSEPRNIQQKLPPEIITLHPRIEEGFFDLMHVQKVLSASTVCKLQSCTHGVPGDLQVYHIGNLLKGDKVNGHLIHKIEPHFNTSWMSWDGCDLDYYCNMGDWPSCTYTGVTQHNHASFVNLLNIETDYTKNFHFHSKRVTAHGDTPQLDLKARPTYGAGEITVLVEVADMELHTKKIEISGLKFASLACTGCYACSSGISCKVRIHVDEPDELTVHVKSDDPDVVAASSSLMARKLEFGTDSTFKAFSAMPKTSLCFYIVEREHCKSCSEEDTKKCVNTKLEQPQSILIEHKGTIIGKQNSTCTAKASCWLESVKSFFYGLKNMLSGIFGNVFMGIFLFLAPFILLILFFMFGWRILFCFKCCRRTRGLFKYRHLKDDEETGYRRIIEKLNNKKGKNKLLDGERLADRRIAELFSTKTHIG