wanglab/gogpt-training-data huggingface dataset:
Protein: DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme) (P06612)
Organism: Escherichia coli (strain K12)
Function: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Interaction partners:
- ATP-dependent DNA helicase RecQ
- Single-stranded DNA-binding protein
- DNA gyrase subunit B
- Ribonuclease HI
- Leucine--tRNA ligase
- Glutamate synthase large chain
- Protein RecA
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit alpha
- DNA gyrase subunit A
Sequence:
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
Protein: RIKEN cDNA 1810065E05 gene (Q5NC41)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MFWSSVSKSLLAVCVVTEFAVIFVESLSCENSMCTNGLCQPMGTCNTSKSCFSQTQEFKMPELSTSLSVQQKGCSLDECTGLAFSATLGDQRTFRYDQRCCTTDKCNQVDTKPSQVPAKANGVQCLACYMEAGRVCIPTPLKCTGSETKCVAVIGTAVGSSSPLSVVMVGSGCATESACNLNMTVLDFVNIRTFCSSGFPVLPTPSSAPDGLGLRSASISTVPVLISLLLLKVLV
Protein: GDP-D-glucose phosphorylase 1 (EC 2.7.7.78) (Q6ZNW5)
Organism: Homo sapiens (Human)
Function: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Inositol oxygenase
Sequence:
MALPHDSNETSYLLPPNNEDWGRQTIPDFVYGQKDLMAEGIQWPRNAPGIPDALPQSPFDAALCSAWKQRVELGLFRYRLRELQTQILPGAVGFVAQLNVERGVQRRPPQTIKSVRQAFDPVQFNFNKIRPGEVLFRLHREPDLPGTLLQEDILVVINVSPLEWGHVLLVPEPARQLPQRLLPGALRAGIEAVLLSLHPGFRVGFNSLGGLASVNHLHLHGYYLAHRLPVEQAPSEPLDPGGHLHLLQDLPAPGFLFYTRGPGPDLESLISRVCRATDYLTDHEIAHNLFVTRGAPPGKTSPSSALTGVRVILWARKSSFGIKDGEAFNVALCELAGHLPVKTSQDFSSLTEAAAVALIQDCRLPPSQAEDVQAALVALMSQEEQ
Protein: Myofilin, isoform E (Q8INF1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFKNHLEMIGRNESPSKKAKFWQSYIRSLKGSEDIRAHEAPRASRPYSSYLDSPSYRSIYDEPATANERVQSSGYRYLPVSRDTYGYSPRAIYDHHYSRTIPANYDAEKAWNDHLKRMQEIERRYPSRYGLYLRDKPLTPNSLVPLEYEPEDKLLAELNKAHRSIL
Protein: Large ribosomal subunit protein uL18 (60S ribosomal protein L5) (P47962)
Organism: Mus musculus (Mouse)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P46777}. Note=Although RP5 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL5 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. {ECO:0000250|UniProtKB:P46777}.
Interaction partners:
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL12m
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS10
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL24
- Elongation factor 2
Sequence:
MGFVKVVKNKAYFKRYQVRFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVNGGEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Protein: Probable enoyl-CoA hydratase EchA6 (EC 4.2.1.17) (P9WNP1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Could possibly oxidize fatty acids using specific components.
Interaction partners:
- Uncharacterized protein Rv0906
- 3-hydroxybutyryl-CoA dehydrogenase
- Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3
- Probable acyl-CoA dehydrogenase FadE23
- Probable acyl-CoA dehydrogenase FadE2
- Acyl-CoA dehydrogenase FadE7
- Possible acyl-CoA dehydrogenase FadE19
- Probable acyl-CoA dehydrogenase FadE1
- Probable acyl-CoA dehydrogenase FadE4
- Probable acyl-CoA dehydrogenase FadE13
Sequence:
MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVLTGQGTAFCAGADLSGDAFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAEIALHTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKFQGA
Protein: L-aspartate decarboxylase (ADC) (EC 4.1.1.11) (Q5JJ82)
Organism: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Function: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine. In vitro, can also catalyzes the decarboxylation of L-glutamate to produce 4-aminobutanoate, but this activity does not seem necessary in vivo. Shows much higher activity with L-aspartate than with L-glutamate. Does not decarboxylate L-tyrosine.
Interaction partners:
- 4-phosphopantoate--beta-alanine ligase
- Ornithine aminotransferase
- Leucine/methionine racemase
- Aminotransferase
- Aspartate aminotransferase
- Histidinol-phosphate aminotransferase
- histidinol-phosphate transaminase
- Plant-type L-asparaginase
- Putative asparagine synthetase
- L-asparaginase
Sequence:
MFPERGASEEEVLRELEEKTREDLTFDSGKILGSMCTYPHPFAVKVVMKYIDRNLGDPGLHIGSQKIEKEAVDMLANLLGLEKGYGHIVSGGTEANILAVRAMRNLAGIEKPELILPESAHFSFIKAAEMLGVKLVWAELNDDYTVNVKDVEKKITDRTIGIVGIAGTTGLGVVDDIPALSDLALDYGLPLHVDAAFGGFVIPFAKALGYEIPDFDFRLKGVKSITIDPHKMGMVPIPAGGIIFREKKFLDSISVLAPYLAGGKIWQATITGTRPGANALAVWAMIKHLGFDGYKEVVKEKMELARWFASELKKIPGIYLIREPVLNIVSFGSEKLEELEKELKARGWGVSAHRGYIRIVVMPHVKREHLEEFLRDLREIAKRL
Protein: Guanylate kinase (EC 2.7.4.8) (GMP kinase) (P15454)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the reversible transfer of the terminal phosphoryl group of ATP to the acceptor molecule GMP. Essential for recycling GMP and indirectly, cGMP.
Interaction partners:
- GMP synthase
- Adenine phosphoribosyltransferase 1
- Hypoxanthine-guanine phosphoribosyltransferase
- Nucleoside diphosphate kinase
- Adenine phosphoribosyltransferase 2
- Ribonucleoside-diphosphate reductase large chain 1
- Ribonucleoside-diphosphate reductase large chain 2
- Ribonucleoside-diphosphate reductase small chain 2
- Ribonucleoside-diphosphate reductase small chain 1
- Inosine triphosphate pyrophosphatase
Sequence:
MSRPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDYNFVSVDEFKSMIKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDLKKRLEGRGTETEESINKRLSAAQAELAYAETGAHDKVIVNDDLDKAYKELKDFIFAEK
Protein: Zona pellucida-binding protein 2 (ZPBP-like protein) (Q6X784)
Organism: Homo sapiens (Human)
Function: Is implicated in sperm-oocyte interaction during fertilization.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q6X786}. Secreted {ECO:0000305}. Note=Released after the acrosomal reaction. {ECO:0000250|UniProtKB:Q6X786}.
Interaction partners:
- Gasdermin-B
- Zinc finger protein Aiolos
- ORM1-like protein 3
- Growth factor receptor-bound protein 7
- Leucine-rich repeat-containing protein 3C
Sequence:
MMRTCVLLSAVLWCLTGVQCPRFTLFNKKGFIYGKTGQPDKIYVELHQNSPVLICMDFKLSKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAETQEEKTVKKRYDFMVFAYREPDYSYQMAVRFTTRSCIGRYNDVFFRVLKKILDSLISDLSCHVIEPSYKCHSVEIPEHGLIHELFIAFQVNPFAPGWKGACNGSVDCEDTTNHNILQARDRIEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHSNCASCCVVCSPATFSPDVNVTCQTCVSVLTYGAKSCPQTSNKNQQYED
Protein: LP06328p (Q8MZG9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSAPTDYLFCPLAYGSALSAIGIYLLRQYMQGGQFTTKTNETGRVAIVTGCNQGIGKETVLELARRGATVYMACRDMKKCENARREIIKATNNQNIFARQLDLCSMKSIRNFAAGFKREQNKLHILINNAGIMDCPKMLTEDGFEMQIGVNHMGHFLLTLLLLDVLKSSAPSRVVVLSSIAHRFGRIKRDDLNSEKSYDRKMAYCQSKLANVLFTRELAKRLSGTGVTVNALHPGVVNTELFRNTPFLGSWFGKLLIAPIIWIFIKTARNGAQTTLYAALDPSLEKVSGRYFSDCKQKHVGSAAQYDDDAQFLWAESEKWTGINI
Protein: Kinesin, putative (Q57TT0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Kinesin-like protein, putative
- FG-GAP repeat protein, putative
- PTHB1 N-terminal domain-containing protein
- Bardet-Biedl syndrome 8 protein
- FG-GAP repeat protein, putative
- Kinesin-like protein
- Kinesin, putative
- Kinesin, putative
Sequence:
MRRGANTTDDSAAAPSSVAVTPREFNRGRYGTEGKQRRIVEPVMHVRTRPVLEYLGESNEKRCVWCLDQQNIVVSIGKSVREPLYGRTVISPTRTVGSMEGTPTSPCVLFGSRCRSTPCTPKRTQHRPPRFLKSCDQVQKSPSRPRTSPWLLPPMSLSTPVELLSDEQLAADRARGVECNSPVPSFHNISGFTFSTAQPTRRAVTPDVSMHRSARAAREDHFRFDFIHNEESTQEEVFEESVLEFVDMALLAQNISIVCYGPTGSGKTYSVIGSASGKRPSPSPLRSAVSPLGKQRTARTVKKPLLPLSGRDVKSTPRPSASAYSGGRPTGTTRLDASSTPTSVDVSSQRITSKALGLECVGEGTASSQLSSSSQAEVDSSNVRELSPQTSHRPKNFASFGEATSCGKGAGEGGGREFVCSEGIGLLPRLVLSLLDRCGSVVQIDRNEGLMAKHPFVTKRATNPTGTFREKSVDKSAHGSLLTLKDLTFYGVELYLDEFRDLLHPTKRRIPILGDIAGLDAFCQKLNEPAFYAGRRGGYGGGCPDAEGNDGASRVGGGVRINSVSDFHRCYAMAARNRVTKAHQCNDVSSRSHAIFILQLHFELTEVLDGFTTALPSPLATGADGGCSNTTTRGHSTSSASSTYLTSAYSYVAVVDLAGSECVKQSKVEGTELREAQYINKSLSAFSAVLLALYQHSNHVPYRDSKLTRLLRPCLEHGRVLVLAHVSPCASKETLGALKFAEQLRHASVRSRNFLNATDDLVAVFEDLKDPDVEERAIKYRKSMEEYMLLCKEVRLAHFSKDSTDRTEGLLSETSSTRPSDGSLVEYSLEEASNFRLLPLGRKKRTRIRDHIISKLTERHLQNHYQAHDDYLQRVKEDIKREQTEYINSVVERRKKDIEEMKLTVEKMKCCNAQLAEENSQPVLRDAHAMEIKQRLKDLAAEVTKCAGEKLLLLEGIRAIRQRTMIQEDLEQCLDEQLHAPPDGSALSGTSLQSMADSNFDDGMESIFNMQLLLSKEMSHLRRESTCFVRCDEIWEGLWARVMRQELMLAVALELEMMEGILLRPESIRWALESVGFDADTVKNVITPASADSRAVKQYEGIDKGVKEHVVNVSKLLGAIDKSLEQSPDCWNSLTKTLHTSGSFNTTSNNSASGSGEGTSMLVAPIPLVMSSGDEVKSVRNLTGCYGDEGKLQEACMEKLLCEGVYCELTFLPFGFDMRELFAAQRSLPPQTSKAKHTLPVGQWGVLRLVRPPNDASSYCLEFMQRTYLTGGKGRDRRLISIPLDEPQLRMSLHVMELDNHVCSGALHDDNPPLPTFPLIVLELKGVPPTPAQPHREAHQVQQQQVQEEWSSYLRGAAQLGTSRQEGTPSNGAALLNNNSDTTSTQGAILTKRLDCGGDLVLPDVAMSSCERGNGIFLLQFSDPVVAMPNRTESVECVVAALAGLTLPSLIVPAAAGAAGACPGRGKTVNSDVKPIDFGFQGIDKACDVHVATYNHMPHILLSAYGGPLRNGPSMKDITKPLTVPVGVGVSPLVYASTMGIFFYFWKDSDVGSSLGSSVATVAATVAATPQTAEATAAPFPPVPINRPSPRGQPSGPFSGAINALVRLTSLTVPNSSGASAGNGNNVSGGSPPERKESASSDVEDFLLHIQKLQSMRKKVRNAVRQQIFDAEDIKAELLYSYSENEFMRGSHIKDVMKEARELIDFQQQFRGNMGIPARVPVQASPALCREMCKFFIPWTLWQWAHRWQTLQDAYRQQQQQLGLFGLGFGGASDTDSEPSAQLSPEATAASMGSLKILDGFCGPTICFGEIPCFLSGMV
Protein: Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Q8WVL7)
Organism: Homo sapiens (Human)
Function: Induces HBG1 expression. May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8VE42}.
Interaction partners:
- tRNA dimethylallyltransferase
- FK506-binding protein-like
- Casein kinase I isoform epsilon
- Casein kinase I isoform delta
Sequence:
MEKEKGNDDGIPDQENSLDFSEHFNQLELLETHGHLIPTGTQSLWVGNSDEDEEQDDKNEEWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARRTSIYHYLFEIVEGCTNSSPQS
Protein: Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin) (Q99697)
Organism: Homo sapiens (Human)
Function: Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity).
Subcellular location: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:P97474}.
Interaction partners:
- Forkhead box protein C1
- Catenin beta-1
- Left-right determination factor 2
- Left-right determination factor 1
- Cytochrome P450 1B1
- Pituitary homeobox 3
- Sonic hedgehog protein
- Lymphoid enhancer-binding factor 1
- Pituitary-specific positive transcription factor 1
- Protein odd-skipped-related 2
Sequence:
METNCRKLVSACVQLGVQPAAVECLFSKDSEIKKVEFTDSPESRKEAASSKFFPRQHPGANEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
Protein: RAN binding protein 1 like 1 (D4A2G9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- GTP-binding nuclear protein Ran
- Ran GTPase-activating protein 1
- Exportin-1
- Regulator of chromosome condensation
- Importin subunit alpha
- Importin subunit beta-1
- Importin subunit alpha
- Importin subunit alpha
- Nuclear pore complex protein Nup54
- Nuclear pore complex protein Nup93
Sequence:
MAAAKDSHEDHDTSTENAEESNHDPQFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGTIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKGDMAKMIMLKRWLRSWKPFQ
Protein: Homeobox protein HAZ1 (Homeobox protein HOX1A homolog) (Q8H991)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcriptional repressor involved in the regulation of gibberrelin (GA) signaling. Binds to the 5'-GATC-3' motif of HD16/EL1 promoter. Functions as a positive regulator of GA signaling by suppressing the expression of HD16/EL1, a negative regulator of GA signaling.
Subcellular location: Nucleus {ECO:0000269|PubMed:21951842}.
Interaction partners:
- Probable lysine-specific demethylase SE14
- Lectin
- Os04g0339800 protein
- MRG family protein, putative, expressed
- Os04g0101300 protein
- Os04g0101100 protein
- Os09g0544500 protein
- ARID transcription factor
- Os02g0708600 protein
- Os02g0708500 protein
Sequence:
MDKTTTSDLVLDNDNIGSNAGSAQEPLTTNGKTSGVRNRYKQTVKRGRKGSQISPSKTYPLRSSHSNVRVLRSASKKKNETPIVPTNDNTAVQRVAKKRKRSKPLRPAPSRVLRSTSEKKNKAHNELLNDGAGVQPAEKKRKVGRPPKGGTPKDDYLMIRKRVRYVLNRMNYEQSLIQAYASEGWKGQSLEKIRPEKELERAKVEILRCKSRIREAFRNLDSLLSEGKLDESMFDSAGEISSEDIFCAACGSKDVTLKNDIILCDGICDRGFHQYCLNPPLLAEDIPQGDEGWLCPACDCKIDCIDVLNELQGVKLSIHDSWEKVFPEAASFLNGSKQIDASDLPSDDSADNDYDPTLAQGHKVDEEKSSGEDGGEGLDSDDSSSEDSESSEKEKSKTSQNGRTVDDLGLPSEDSEDGDFDPAGPDSDKEQNDESNSDQSDESDFTSDSDDFCAEIAKSCGQDEISGPSSSQIRTVDRTDGSGFDGEPNAENSNLAFMETELEQDMVLPISSKRQVERLDYKKLYNEAYGKASSDSSDDEEWYGNSTPEKGNLEDSETDSLAESPQGGKGFSRRAPVRYHNNEHTPQNVRPGGSVSDQQTEVLCSNSNGSTAKNRHFGPAINQKLKAHFKEDPYPSRATKENLAQELGLTFNQVTKWFSSTRHYARVAATKKENNIENHTAENNNNTNTVDSIQLRGSNDIVSVDRNDMVSEERTGQSNLNEGTPLRSDTSCGQSVAVTPMVHPENQGNDSSSNVRTPNAKSAEKLIPGLENSDEARRKAVQRELRKMKTGR
Protein: Nanog (A8QWW8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MSVDLSGPHSLPSCEEASNSGDSSPMPAVHLPEENYSCLQVSATEMLCTETASPPPSSGDLPLQDSPDSSSNPKLKLSGPRLTRALRRKKRTRSSPRKQKMRTVFSQAQLCALKDRFQRQRYLSLQQMQDLSTILSLSYKQVKTWFQNQRMKCKRWQKNQWLKTSNGLTQGSAPVEYPSIHCSYSQGYLMNASGNLPVWGSQTWTNPTWNNQTWTNPTWSNQTWTNPTWSNQAWSTQSWCTQACNSQTWNAAPLHNFGEDSLQPYVPLQQNFSASDLEANLEATRESQAHFSTPQALELFLNYSVNSPGEI
Protein: ATPase inhibitor mai-1, mitochondrial (ATP synthase F1 subunit epsilon) (P37209)
Organism: Caenorhabditis elegans
Function: Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Nuclear Hormone Receptor family
Sequence:
MSGSGSGSGAGHGGGSGGSIREAGGSLGMMGATREEEYFRRQQKDQLDNLKKKLEADMTQSQQEIRDHEKVLEQHQQRLKEIEKGHGT
Protein: KCNQ potassium channel, isoform J (A0A0B4KEP9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLASNQNLTHKPISLIHKLPADEEDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGKQGSKAKDVYASKISLASRVVKVERQVADIEEKLDILIKAYMEDRDRFLALPLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSELRSLTATQTPTTTTDAIATQTPMPPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELENRTKKRVTLSLHRSTSEPYSKQEQRITIPDEGADSLDSSAKPTPPDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSDIGVEVDVDADADGDCDESTEDTALLQCATRTAIVITPISPVSSAHNLQQLNDQTTTLNKSNLLPPDSG
Protein: Regulatory protein NPR5 (BTB/POZ domain-containing protein NPR5) (Protein BLADE ON PETIOLE 2) (Q9ZVC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB, YAB1/FIL and YAB3, and through positive regulation of LOB domain-containing genes LOB, LBD6/AS2 and LBD36. Promotes and maintains a developmentally determinate state in leaf cells through the negative regulation of JAG, JGL and class I KNOX genes. Is also involved in nectary development, formation of normal abscission zones and suppression of bract formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15805484}. Nucleus {ECO:0000269|PubMed:15805484}.
Interaction partners:
- Transcription factor TGA6
- Transcription factor TGA5
- Transcription factor TGA7
- Transcription factor TGA2
- Homeobox protein knotted-1-like 6
- Homeobox protein knotted-1-like 1
- Ankyrin
- AT3G13950 protein
- Ankyrin repeat-containing protein BDA1
- Transcription factor TGA1
Sequence:
MSNLEESLRSLSLDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQPVTGIDPTQHGSVPASPTRGSTAPAGIIPVNSVGYEVFLLLLQFLYSGQVSIVPQKHEPRPNCGERGCWHTHCSAAVDLALDTLAASRYFGVEQLALLTQKQLASMVEKASIEDVMKVLIASRKQDMHQLWTTCSHLVAKSGLPPEILAKHLPIDVVTKIEELRLKSSIARRSLMPHNHHHDLSVAQDLEDQKIRRMRRALDSSDVELVKLMVMGEGLNLDESLALHYAVESCSREVVKALLELGAADVNYPAGPAGKTPLHIAAEMVSPDMVAVLLDHHADPNVRTVGGITPLDILRTLTSDFLFKGAVPGLTHIEPNKLRLCLELVQSAAMVISREEGNNSNNQNNDNNTGIYPHMNEEHNSGSSGGSNNNLDSRLVYLNLGAGTGQMGPGRDQGDDHNSQREGMSRHHHHHQDPSTMYHHHHQHHF
Protein: Hd1 (Q9FRZ6)
Organism: Oryza sativa (Rice)
Interaction partners:
Sequence:
MNYNFGGNVFDQEVGVGGEGGGGGEGSGCPWARPCDGCRAAPSVVYCRADAAYLCASCDARVHAANRVASRHERVRVCEACERAPAALACRADAAALCVACDVQVYSANPLARRHQRVPVAPLPAITIPATSVLAEAVVATATVLGDKDEEVDSWLLLSKDSDNNNNNNNNNDNDNNDNNNSNSSNNGMYFGEVDEYFDLVGYNSYYDNRIENNQDRQYGMHEQQEQQQQQQEMQKEFAEKEGSECVVMELWEQTRPPP
Protein: Organic cation/carnitine transporter 1 (AtOCT1) (Q9CAT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High affinity carnitine transporter involved in the active cellular uptake of carnitine. Also transports organic cations. Regulates lateral root development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17521409}; Multi-pass membrane protein {ECO:0000269|PubMed:17521409}.
Interaction partners:
- 26S proteasome regulatory subunit 10B homolog A
- 8-amino-7-oxononanoate synthase
- DExH-box ATP-dependent RNA helicase DExH4, chloroplastic
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Sequence:
MEPSKQEVPKLMETPPNISNDSSATEKGEATRQQQLPNNRYALTVDEVIEQHIGALGFAQILHALLVSIAWIFDAQTTLISIFSDAQPAARLLATGAIVEGASLCGLASGEWEWIGPKSDTVVSEWNLICQHKFLVAVPSTLFFIGSLFGSGVYGYLADSWFGRKKTLLLSCVLTFVTAFAISFSPNVWVYAFLRFANGFFRSGIGSCCIVLATEIVGKKWRGQVGQYGFFFFTLGFLSLPLMAYLERKSWRNLYRIISFLPLGYAVCLLPFAYESPRWLLVKGRNKEAMVVLKKLARLNGKQLPADLSLVDPIPERDDQTSSSEKFWKTKWAVKRIIMVMMAGFGSGFVYYGIQLNAENLNFNLYLTVAVNALMEFPAVFIGSFLLGVMNRRPLFSNSSYLAGFACLLCAVLSIHRVIRAISVAKWLQLAVEAVGFMASSTAYDVLYVYCVELFPTNVRNTAVSLLRQAFMLGASAAPLLVALGRESAMMSFIVFGVASVLSGIVSLWLRETRNAPLYETLAQQGKAEEIENETIMIT
Protein: Plasmodesmata-located protein 7 (PD-located protein 7) (Cysteine-rich repeat secretory protein 60) (Q0WPN8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates cell-to-cell trafficking.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8GXV7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8GXV7}. Cell junction, plasmodesma {ECO:0000269|PubMed:20886105}. Note=Co-localizes with the Grapevine fanleaf virus (GFLV) 2B-MP at the base of tubules within modified plasmodesmata. {ECO:0000269|PubMed:20886105}.
Interaction partners:
- Heavy metal-associated isoprenylated plant protein 42
- Heavy metal transport/detoxification superfamily protein
- FT-interacting protein 4
- WAT1-related protein At2g40900
Sequence:
MPMAKLRNIIKTLSIFFFLIAATAPSLSSATSATDTFVFGGCSQQKFSPASAYESNLNSLLTSLVNSATYSSYNNFTIMGSSSSDTARGLFQCRGDLSMPDCATCVARAVSQVGPLCPFTCGGALQLAGCYIKYDNISFLGQEDKTVVLKKCGSSEGYNTDGISRRDAVLTELVNGGGYFRAGGSGDVQGMGQCVGDLTVSECQDCLGTAIGRLKNDCGTAVFGDMFLAKCYARYSTDGAQHYAKSHNYKTNYGGEKTFAIIIGLLAAVVLLIIFLLFLRGVCSRGGDFSILHSFTLI