wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphatidylethanolamine N-methyltransferase (PE methyltransferase) (PEAMT) (PEMT) (EC 2.1.1.17) (Choline-requiring protein 2) (P05374)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME). Preferentially converts di-C16:1 substrates.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03217, ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03217}.
Interaction partners:
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Phosphatidylserine decarboxylase proenzyme 2
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Choline/ethanolaminephosphotransferase 1
- Lysophospholipid acyltransferase
- Protein INO2
- Protein INO4
- Inositol-3-phosphate synthase
- Phospholipase D1
Sequence:
MSSCKTTLSEMVGSVTKDRGTINVEARTRSSNVTFKPPVTHDMVRSLFDPTLKKSLLEKCIALAIISNFFICYWVFQRFGLQFTKYFFLVQYLFWRIAYNLGIGLVLHYQSHYETLTNCAKTHAIFSKIPQNKDANSNFSTNSNSFSEKFWNFIRKFCQYEIRSKMPKEYDLFAYPEEINVWLIFRQFVDLILMQDFVTYIIYVYLSIPYSWVQIFNWRSLLGVILILFNIWVKLDAHRVVKDYAWYWGDFFFLEESELIFDGVFNISPHPMYSIGYLGYYGLSLICNDYKVLLVSVFGHYSQFLFLKYVENPHIERTYGDGTDSDSQMNSRIDDLISKENYDYSRPLINMGLSFNNFNKLRFTDYFTIGTVAALMLGTIMNARFINLNYLFITVFVTKLVSWLFISTILYKQSQSKWFTRLFLENGYTQVYSYEQWQFIYNYYLVLTYTLMIIHTGLQIWSNFSNINNSQLIFGLILVALQTWCDKETRLAISDFGWFYGDFFLSNYISTRKLTSQGIYRYLNHPEAVLGVVGVWGTVLMTNFAVTNIILAVLWTLTNFILVKFIETPHVNKIYGKTKRVSGVGKTLLGLKPLRQVSDIVNRIENIIIKSLVDESKNSNGGAELLPKNYQDNKEWNILIQEAMDSVATRLSPYCELKIENEQVETNFVLPTPVTLNWKMPIELYNGDDWIGLYKVIDTRADREKTRVGSGGHWSATSKDSYMNHGLRHKESVTEIKATEKYVQGKVTFDTSLLYFENGIYEFRYHSGNSHKVLLISTPFEISLPVLNTTTPELFEKDLTEFLTKVNVLKDGKFRPLGNKFFGMDSLKQLIKNSIGVELSSEYMRRVNGDAHVISHRAWDIKQTLDSLA
Protein: Na/Pi cotransporter 4 (Q8CJH9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MATMVELSPTSEQCEFVLGLPVNKKTPPRKVPSLCSMRYSIAFIAHICNFTLIAQNSIISITMVAMVNNTDQPSHLNSSTEWFPDGLNGDQHEASKHLSIKAPVYNWSPQTQGIIFSSVQYGMMLMQGPGGYLAGKLGTKKVVGIALLGSSLLTLCIPLAANLGLAFLLATRAVQGLTQGAGYGGQFALWQKWAPPNERSRLCSIAMSGMILGIFAVLLVGGIISEALGWPFVFYIFGSIGVVCCLLWLILVYDDPVSHPWISSPEKEYILSSLDQQFNSEEQPLPIKAMLKSLPLWSMCLCSMTHQWLVNTLIIYTPTYISSVFKVNIRDNGLLSSLPFFVAWVIGILGGLLADFLLSKNFRLITVRKIITILGNTPPAALVVALPYVQSSYIATTTFLTLSCGLSPLCQSGVYINALDIAPRYASLLMGTSRGLAHSSAVMVPIVAGFFLNQDSEFGWRNFFFVLFAINLFGLIIYLVFAKADIQEWARERKLTRL
Protein: Transcription elongation factor SPT6-like (Q9CAM1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription elongation factor that enhances the transcription elongation by RNA polymerase II (RNAPII).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- FACT complex subunit SSRP1
- FACT complex subunit
- FACT complex subunit SPT16
- Protein CTR9 homolog
- Protein IWS1 homolog 2
- Protein IWS1 homolog 1
- Protein CDC73 homolog
- Protein LEO1 homolog
- Protein RTF1 homolog
- Transcription elongation factor SPT4 homolog 2
Sequence:
MNRIDEEPQIHEDPVENREEDDEDEDDQYEFDDGFLVNGSDDGEEEEEQRHCSEKKSRSRRKKDESFTLHEDDYLLLKDNNDTFQRNKYKRLKKSSEEEDKINNDDDDDDLSHFIVDEDDHGAQGMRRKKMKYKQGTDSNALRYANDVFGDPEELLKLRKKDLKYNEKIERKLEDEFEPMVLSEKYMTEKDDEIRKLDVPERMQIFEEAIGIVSLDDMSIQEESNWIYARLLQEQGQGCLINKDDIVKFLEMFHVQKLEIPFIAMYRKEQCRSLLDSSDDDHDGSDFNLDKKLETKWHKVLWMIQDLDRKWVLLRKRKTALFGYYTKRFEEETCMSDLNKSLFESVIKSLQAAETEREVDDVDSKFNLHFPHCEIDEGQYKRPNRKSQYSICSKFGIKEFANKFGYSAEQLGLALSLEKVFVDELEDAKKTPEEMALNYECAMFGDSQAVLKGARHMAAVEISCEPSIRKYVRGIFMENAVVSTSPTPDGNVVIDSFHRFSAVKWLSEKPLRKFDGVQWLLIQKAEEEKLLQVTFKLPENQMNRIISECSEHYLSVGVSKYAQLWNEQRKLILEDAVHGFVLPSMEKEARSLLTSRAKTQLLSEYGQVLWNKVSSGPYRRNNNTSEEEAAPRVLACCWGPGNPETTFVMLDSSGELVDVLYSGSIGLRSRDVNDQKRKKMDQDRFLKFIRDHQPDVLALAAVNLSCVRLKDEIYEAIFQMVEELPLNYVDDRIYDFPLVYADESLPRLYENSRISSEQLPQQAGIVKRAVSLGRYLQNPLAMISTLCGPGRDILSWKLHSFQDFLDPDEKYEMVEQVMVDITNQVGIDINLAASHEWLFSPLQFVSGLGPRKAASLQKSLVRAGSIFVRKELINHGIGKKVFVNAAGFLRIRRSGLACSSSQFIDLLDDTRIHPESYGLAQELAKDVYAHDTVRGDEDDAIEMAIEHVRDEPASLRKIVLDEYLRSKNQENKKETYSLIMRELSCGFQDWRSLFKEVDSDEEFYMISGETKETIGEGRIVQATVKKVTSGKAKCVLDCGLPGILLKEDYSDDGRDIVDLSNKLCEGDIVTCKVKSILKQRYHVLLVCKESEMRKHRNLGDVDDYYHEEKRNSVLIEKEKVPKEKKQFKSRMIVHPRFQNITAEQATVYLSDKNIGESIVRPSSRGLNHLTLMIKISDNVYANKEIIEGEKENKDIVSLQRIGKTLKIGNETFEDLDEVMDRYVDPLVTHLMTMLNHRKFRTGTKSEIDDLLRVEKGVNPKMVVYSFGVSHEHPGSFILSYIRSANPHHEYIGLYPKGFKFRKRMFGDLDKLAAYFKRHIDNQ
Protein: FAD-binding monooxygenase prhK (EC 1.14.13.-) (Paraherquonin biosynthesis cluster protein K) (A0A1E1FFN4)
Organism: Penicillium brasilianum
Function: FAD-binding monooxygenase; part of the gene cluster that mediates the biosynthesis of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase prhL (By similarity). Synthesis of DMOA is followed by farnesylation by the prenyltransferase prhE, methylesterification by the methyl-transferase prhM, epoxidation of the prenyl chain by the flavin-dependent monooxygenase prhF, and cyclization of the farnesyl moiety by the terpene cyclase prhH, to yield the tetracyclic intermediate, protoaustinoid A (By similarity). The short chain dehydrogenase prhI then oxidizes the C-3 alcohol group of the terpene cyclase product to transform protoaustinoid A into protoaustinoid B. The FAD-binding monooxygenase prhJ catalyzes the oxidation of protoaustinoid B into preaustinoid A which is further oxidized into preaustinoid A1 by FAD-binding monooxygenase phrK. Finally, prhA leads to berkeleydione via the berkeleyone B intermediate. PrhA is a multifunctional dioxygenase that first desaturates at C5-C6 to form berkeleyone B, followed by rearrangement of the A/B-ring to form the cycloheptadiene moiety in berkeleydione. Berkeleydione serves as the key intermediate for the biosynthesis of paraherquonin as well as many other meroterpenoids (Probable). The cytochrome P450 monooxygenases prhB, prhD, and prhN, as well as the isomerase prhC, are probably involved in the late stage of paraherquonin biosynthesis, after the production of berkeleydione (Probable). Especially prhC might be a multifunctional enzyme that catalyzes the D-ring expansion via intramolecular methoxy rearrangement, as well as the hydrolysis of the expanded D-ring (Probable).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MTISTTALGGGATTATRKQVEAKYEEERQIQLQSRGMVEDIEITRNASFEQFAKDPWAAPKQVDVEIQRERLLQQAHHKIIIIGAGFGGLLFAVRLIQTGKFKADDIILVDSAAGFGGTWYWNRYPGLMCDTESYIYMPLLEETGYMPRNKYASGNEIREHAERIAEKYALSERAIFRTVVQSLDWEEEGKVWKIAGVKLGKNDECQQPFQLIADFPIMASGAFASPRVPNYPNIFDYKGKLFHTARWDYKYTGGSIENPKMSGLADKRVAIIGTGATAIQIVPQLAKNSRELFVFQRTPAAVDVRNNYPTDPARFKSEIQGDGPGWQRRRQINFNAFTCNEKTLPTDNKIGDGWTRMPSFSVLIGGPQSLEPDYIDQIRPIDMARQSEIRSRVHKLVESTAIADSLTPWYPGWCKRPCFHDEYLQSFNSSNVQLVDIRHDGISRFTPNGLVANGVEYELDAIILSTGYTVPVTRASPSGRANITVTGRRGVTMEEKWANGLATLHGVMTRDLPNLFFAGTSQAGACVNLTYALDQNAIHVAHILSEAVKRQPSDCTKLVIQPTHEGEEAWTMEILQRAAGFRGIAGCTPGYLNGYGMDASSLKPEEQMNMARLAAWGEGIASYVDALEGWRSEGQLEGVEMTFFA
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) (Q91YQ5)
Organism: Mus musculus (Mouse)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:E2RQ08}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:E2RQ08}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3
- Malectin
- Protein transport protein Sec61 subunit gamma
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
Sequence:
MESPVALLLLLLLCLGALAPTPGSASSEAPPLVNEDVKRTVDLSSHLAKVTAEVVLVHPGGGSTSRASSFVLALEPELESRLAHLGVQIKGEDEEDNNLEVRETKIKGKSGRFFTVKLPVALDPGSKISVVVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASRNVESYTKLGNPSRSEDVLDYGPFKDIPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIQVDSPYDISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRLGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKAVTSEIAVLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYLENEKLSSGKRQELVTKIDHILDAL
Protein: COP9 signalosome subunit 7B (J3QT73)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
YTDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKGPSCPLELPANACSPKIFNSSWLHLGRDGGIDAPLSAEGPVAASVFSPLLG
Protein: Ubiquitin fusion degradation protein 3 homolog (G5EES6)
Organism: Caenorhabditis elegans
Function: Plays a role in protein ubiquitination, sorting and degradation through its association with cdc-48.1 and/or cdc-48.2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25721663}.
Interaction partners:
- Ubiquitin fusion degradation protein 1 homolog
- UBX domain-containing protein 2
- Ubiquitin conjugation factor E4 ufd-2
- Nuclear protein localization protein 4 homolog 2
- Nuclear protein localization protein 4 homolog 1
- Transitional endoplasmic reticulum ATPase homolog 1
- UBX domain-containing protein 6
- UBX domain-containing protein 1
- DUF19 domain-containing protein
- Transitional endoplasmic reticulum ATPase homolog 2
Sequence:
MADDGLGDVPMETESMPQYTISHVIEAHKSDTKALAVTQGGCLISGGRDETVKFWAKKGKQYTKTHAFEQPKGITVNSIAYAELADGWRLFVGRRDGTIAVFGPSQAEPYAIFNEHKQNVCCLHINEKATHMLSGSWDSNVIIWPITELNSSSFTFQTIVCPGHTLSVWALASFPDLPNTYLSASADKTIRMWFGDTTLSVFKGHTDVVRALVVLSSSHFLSAGNDGHIIHWDVASASILRKFATQAHEFIYSMTLSDSHILTTGEDGTLEFWAIDGGKDGNLAIVSEAVIQLPTTNTWDAKVLLNSDIAVAGSDGRIYIMTTDKNRKADDDILDAFDAEVVAKLTAKTERMKQEEHETVTIKVDIDDRPTQLNLKYKKGTDPGLCAQEFLSENNLPIHYLEEITRFIKDRIPEARAFDLKSGKKVIVDGKEYDYALGVNFGKGEPDKQMPFNVNESPQFAAQRFVERHQLPVSVIPSLAGMISQEMDKLSKGAASAQSGYEDPFTGPGRYVPQGSSNSGGHGADPFTGSGRYVPQASNSSGFDTGFSGDPLTGDGGYRASAPENTGSHAVPLSSLPQNKKKPRGPLVPVPDFYIIGLAGKGEKAIAKLKELNEKQDAFQLNPDQINGLEELFVLPTSSNYSSEVTQSAFEMSLQWPVEHLTPVLDFLRIALTHHSLNSYFCDRERGQELVGRLIAILVSDPADVALKVLVCRCIANAFSHPVGRNLFASTELSTLAPLVVRQVLNEKTVLQMSAATALANWSLALLQQSEQCEQLGPKEDLLRAILNGIESVDSFGYLGEDAIIRLLQALVTVMWGDASVIRLAKNRNIAQIAARLKDAVSNDSGKNIARDIVEMTYAV
Protein: LexA repressor (EC 3.4.21.88) (P0A7C2)
Organism: Escherichia coli (strain K12)
Function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment.The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA.
Interaction partners:
- Protein RecA
- DNA repair protein RecN
- DNA polymerase IV
- Protein UmuC
- DNA damage-inducible protein I
- DNA damage-inducible protein F
- Uncharacterized protein YebG
- UvrABC system protein A
- Cell division inhibitor SulA
- Regulatory protein RecX
Sequence:
MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLQEEEEGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPNADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFKPIVVDLRQQSFTIEGLAVGVIRNGDWL
Protein: Receptor protein kinase-like protein At4g34220 (Q94C77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Lycopene beta/epsilon cyclase protein
- IQ-domain 21
- Protein IQ-DOMAIN 3
- IQ-domain 24
- AGAMOUS-like 79
- Probable protein phosphatase 2C 64
- Actin-related protein 2/3 complex subunit 5A
- Enhancer of polycomb-like protein
- Protease Do-like 4, mitochondrial
- Protein NSP-INTERACTING KINASE 1
Sequence:
MTSNRSNLLFSLVLFHFLFVPTQLQALNTDGVLLLTFKYSILTDPLSVLRNWNYDDATPCLWTGVTCTELGKPNTPDMFRVTSLVLPNKHLLGSITPDLFSIPYLRILDLSSNFFNGSLPDSVFNATELQSISLGSNNLSGDLPKSVNSVTNLQLLNLSANAFTGEIPLNISLLKNLTVVSLSKNTFSGDIPSGFEAAQILDLSSNLLNGSLPKDLGGKSLHYLNLSHNKVLGEISPNFAEKFPANATVDLSFNNLTGPIPSSLSLLNQKAESFSGNQELCGKPLKILCSIPSTLSNPPNISETTSPAIAVKPRSTAPINPLTEKPNQTGKSKLKPSTIAAITVADIVGLAFIGLLVLYVYQVRKRRRYPESSKFSFFKFCLEKNEAKKSKPSTTEVTVPESPEAKTTCGSCIILTGGRYDETSTSESDVENQQTVQAFTRTDGGQLKQSSQTQLVTVDGETRLDLDTLLKASAYILGTTGTGIVYKAVLENGTAFAVRRIETESCAAAKPKEFEREVRAIAKLRHPNLVRIRGFCWGDDEKLLISDYVPNGSLLCFFTATKASSSSSSSSSLQNPLTFEARLKIARGMARGLSYINEKKQVHGNIKPNNILLNAENEPIITDLGLDRLMTPARESHTTGPTSSSPYQPPEWSTSLKPNPKWDVYSFGVILLELLTSKVFSVDHDIDQFSNLSDSAAEENGRFLRLIDGAIRSDVARHEDAAMACFRLGIECVSSLPQKRPSMKELVQVLEKICVLV
Protein: Stellate protein CG33236/CG33240/CG33244/CG33245 (Q7KV12)
Organism: Drosophila melanogaster (Fruit fly)
Function: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.
Interaction partners:
- Casein kinase II subunit alpha
- Casein kinase II subunit beta
- Stellate protein CG33246
- Segment polarity protein dishevelled
- Stellate protein CG33243
- Ste:CG33242
- Stellate protein CG33247
- Stellate protein CG33238
- Stellate protein CG33237
- Stellate protein CG33239/CG33241
Sequence:
MSSSQNNNSSWIDWFLGIKGNQFLCRVPTDYVQDTFNQMGLEYFSEILDVILKPVIDSSSGLLYGDEKKWYGMIHARYIRSERGLIAMHRKYLRGDFGSCPNISCDRQNTLPVGLSAVWGKSTVKIHCPRCKSNFHPKSDTQLDGAMFGPSFPDIFFSMLPNLTSPLDDPRT
Protein: Oxysterol-binding protein homolog C2F12.05c (O14340)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Vesicle-associated membrane protein-associated protein scs2
- Vesicle-associated membrane protein-associated protein scs22
- UBA domain-containing protein 7
- Protein atp12
- Protein mss51
- SWIRM domain-containing protein laf2
- Serine/threonine-protein kinase ppk1
- Protein transport protein sec22
- Syntaxin-like protein psy1
- Phosphatidylinositol 4-kinase stt4
Sequence:
MEHPSPDSVSSTSSSDHKKAELSDSLKQLQLLQAFQAGDIKQVDNLLHNKSKDECTHALFISIQCANVQMVKHILSVFDVDVNAYDKNKNTPLHLAAMAGRQDIVEALLLHPDINYNLVNANNKKAYQVATSPQLMDFMKGFYVTYTKETAREFKKAFKERNLESMDYLMRHNEFNDAIDLNEVDIKTGQTYLHVATKAKDAELVKWLLDNGADPYRRDKFGKLPTDYTKDENMRSLLRSYSGNRDSSSAPAVPQHMSGYLKKWTNYKSGYKLRWFTLNNGVLSYYKNQDDASSACRGSINLKLARLVHDPKQPTVFQVIGKGSVRYSVKANSPVEAKKWIAAISSAIENDEEANKPNVTADNASFGTHDLAPAAHKFTQSNASGNSGWDDNESDIDRAQLPSRENFEFNVNIAKLQVETLHKLIDSAMQTEKVKKDPSLSQVFDGISNSFNTLHKTVLEMLDLQRQAEHYYKRKLDNAKAINALWAENLKTVVEEQDQIEERYHRSEAHRRRTKRAFRRLAASLKKRPSDKDNKLHIHYDDGAMSSTSYSTDFTDDEEETNTKDEFFDVDAHDNNHANKAEPSQTANNVHEIREPSFSSEHKPQPSLKTTTDVSSPETKQNIADIRKTTLTDQTEEFTERRDNNGSIPSKQPSDEQHLGKESLPSQQSTVSNHHRKESIPSKQPTEGQHARQESLPSQQTTETKHLRKESTPSKQPTEGQHTRQESLPSQQTTETKHLRKESIPSKQPTEGQHARQESLPSQQTTETKHLRKESIPSKQPSGGQQLRQESLPSQQSSESKQSTQHQQPVEVQKSIQSDVSAPKAKEVSEKPVSHQAKPSNASQLSRNTDDTQAKEAPKEASIPDNASTASTKVSNDSHLKPDADKKSVSSELTHASKPSLDEKTMQLAKQIAVSFHGYEAPTRENLDVNDDRPKISLWGILKGMIGKDMTKMTLPVSFNEPTSLLQRVAEDMEYTELLDQASHNKDPYQRILYVAAFAASEYASTLNRVAKPFNPLLGETYEFCHPQRGFRFIVEQVSHHPPVGAAYSESANWKYYGESSVKSKFYGKSFDISPLGTWFLELRHPSGEVELYTWKKVTSSVVGIILGSPSVDNYGQMHIVNHSSGINCVLDFKPRGWRGTNAHEVKGSVQSTDDTPKWMVNGHWNDKIFGQQPNGNKILLWQNHERPPRPFNLTPFAISLNALTPQLKPWLPPTDTRLRPDQRAMENGQYDLAASEKNRLEEKQRKKRRMREQGEMPPWSPRWFSAAKHPVTGEDYWQFNNEYWKIREEAGEAHLAGKEFEWPNVDDIF
Protein: Sorting nexin-25 (Q3ZT31)
Organism: Mus musculus (Mouse)
Function: May be involved in several stages of intracellular trafficking.
Subcellular location: Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MDRVLRDVFDYSYRDYILSWYGNLSRDDGQLYHLLLDDFWEIVKQIRQRLSHVDVVKVVCNDIVKALLTHFCDLKAATARHEEQPRPFVLHACLKDSHDEVRFLQTCSQVLVLCLLPSKDIQSLSLRTMLAEILTTKVLKPVVELLSNPDYINQMLLRQLEYREQMSEHHKRAYTYAPSYEDFIKLINSNSDVDFLKQLRYQIVVEIIQATTISSFPQLKRHKGKESAAMKTDLLRARNMKRYINQLTVAKKQCEKRIRILGGPAYDQQEDGASDEGEGPQSQKILQFEDIMTNPFYRERFGTYMERIDKRALVGFWESAEHLKNANKSEIPQLVSEMYQNFFVESKEISVEKSLYKEIQQCLVGNRGIEVFSKIQADVSEVLRERYYPSFLVSDLYEKLMREEEEEEPDAQLASEKDELGSGGEAGEEAVEGTSGVSDPASFAVIKLRELNEKLEYKRQALSSIQNAPKPDKKIISKLKDEILLIEKECTALQLHMARTDWWCENLGLWRASITSAEVTEENGEQMPCYFVRVNLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDHKFLGKSRNQLNAFLQNLLSDERLFQSEALYAFLSPSPDYLKVIDVQGKKTSFSLSSFLEKLPRDFFSHQEEEIEEDSDLSDYGDDVDGKKDSLAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINKQIRDTVSWISSEQMLVYYISAFRDAFWPNGKLAPPTRIRSVAQSQETKQRAQQKLLENIPDTLQSLVGQQNARHGIIKIFKALQETKANKHLLYVLMELLLTELCPELRAHLDQFKAGQV
Protein: Catenin alpha-1 (G3XAM7)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}. Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGNCDTCGALQGLKGWPPPLCWPLTGWTAPCP
Protein: Pleckstrin homology domain containing A7 (H0YDE2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKAKPKVQEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLGQGERTGLPSSRYLSRPLPGDLGSVC
Protein: G-protein-signaling modulator 3 (Q3U1Z5)
Organism: Mus musculus (Mouse)
Function: Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MEAERPQEEDGEQSLPQDDQGWPPVNATARPWRSAPPSPPPPGTRHTALGPRSGSLLSLQTELLLDLVAEAQSRRLEEQRATFHTPEAPPNLAPAPPRLLEDKEQLYSTILSHQCQRIEAQRSDPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC
Protein: E3 ubiquitin-protein ligase NEURL3 (EC 2.3.2.27) (Lung-inducible neuralized-related C3CH4 RING domain protein) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL3) (Q8CJC5)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity. Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96EH8}.
Interaction partners:
Sequence:
MGSLLSPEANAEVPREALSFHGNATGAQVHLDDQRSTARRRSTFHDGIVFSQRPVWPGERVALRVLRHEEGWCGGLRVGFTRLDPAQVAASCLPPFVCPDLEEQSPTWAALLPEGFVRAGNVVCFWVNRRGWLFAKVNAGRPLLLRKDVLVQGAPLWAVMDVYGTTKAIELLDPKANAWIRSGEPVPESEVISGEECVICFHNTANTRLMPCGHSHFCGSCAWHIFKDTARCPICRWQIEEVAVVSSLKAEEGS
Protein: Protein tesmin/TSO1-like CXC 8 (AtTCX8) (Q700D0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in development of both male and female reproductive tissues.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Proline-rich spliceosome-associated
- Retinoblastoma-related protein 1
- THO complex subunit 4B
- F-box associated ubiquitination effector family protein
- Ras-related protein RABG3d
- Protein ALWAYS EARLY 3
- Transcription factor E2FC
- Protein ALWAYS EARLY 2
- Protein ALWAYS EARLY 1
- Histone-binding protein MSI1
Sequence:
MTGNADSGKIATEKDPRKLVFTKLEVSPVFRESPVKELPLFPPISREHSEAKDKTDEEGITSRKHKGCRCKQSKCLKLYCDCFASGVVCTDCDCVDCHNNSEKCDAREAAMVNVLGRNPNAFSEKALGSLTDNQCKAAPDTKPGLLSRGCKCKRTRCLKKYCECFQANLLCSDNCKCINCKNVSEAFQPPAFSAHNSPQVYRRRRDRELTEWNSCPAPLFSIPDNSIQNALGSPMSCSPKLPYRKKRSLMGYTSTLLPDLGDLCSLLVAASESATTTAEDQNRIFTKPDDKEAIELSSESESRNVEEEIQSRGRLIELIDVQYNGEEDSQCKTKTSVNETDIYMEQERAVLETFRDCLQKFIKSRLES
Protein: Neuropeptides B/W receptor type 2 (G-protein coupled receptor 8) (P48146)
Organism: Homo sapiens (Human)
Function: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Neuropeptide W
- Neuropeptide B
- Neuropeptides B/W receptor type 1
Sequence:
MQAAGHPEPLDSRGSFSLPTMGANVSQDNGTGHNATFSEPLPFLYVLLPAVYSGICAVGLTGNTAVILVILRAPKMKTVTNVFILNLAVADGLFTLVLPVNIAEHLLQYWPFGELLCKLVLAVDHYNIFSSIYFLAVMSVDRYLVVLATVRSRHMPWRTYRGAKVASLCVWLGVTVLVLPFFSFAGVYSNELQVPSCGLSFPWPEQVWFKASRVYTLVLGFVLPVCTICVLYTDLLRRLRAVRLRSGAKALGKARRKVTVLVLVVLAVCLLCWTPFHLASVVALTTDLPQTPLVISMSYVITSLSYANSCLNPFLYAFLDDNFRKNFRSILRC
Protein: Transcription factor MYB102 (Myb-related protein 102) (AtMYB102) (Myb-related protein M4) (AtM4) (Q9LDR8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that may function in osmotic stress and wounding signaling pathways (Probable). Contributes to basal resistance against the herbivore Pieris rapae (white cabbage butterfly) feeding.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
Sequence:
MARSPCCEKNGLKKGPWTSEEDQKLVDYIQKHGYGNWRTLPKNAGLQRCGKSCRLRWTNYLRPDIKRGRFSFEEEETIIQLHSFLGNKWSAIAARLPGRTDNEIKNFWNTHIRKKLLRMGIDPVTHSPRLDLLDISSILASSLYNSSSHHMNMSRLMMDTNRRHHQQHPLVNPEILKLATSLFSQNQNQNLVVDHDSRTQEKQTVYSQTGVNQYQTNQYFENTITQELQSSMPPFPNEARQFNNMDHHFNGFGEQNLVSTSTTSVQDCYNPSFNDYSSSNFVLDPSYSDQSFNFANSVLNTPSSSPSPTTLNSSYINSSSCSTEDEIESYCSNLMKFDIPDFLDVNGFII
Protein: Zinc finger CCHC-type containing 8 (F5H6J5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKDCPMPRNAARISEKRKEYMDACGEANNQNFQQRYHAEEVEERFGRFKPGVISEELQDALGVTDKSLPPFIYRMRQLGYPPGWLKEAELENSGLALYDGKDGTDGETEVGEIQQNKSVTYDLSKLVNYPGFNISTPRGIPDEWRIFGSIPMQACQQKDVFANYLTSNFQAPGVKSGNKRSSSHS