wanglab/gogpt-training-data huggingface dataset:
Protein: Cell division protein ZapE (Z ring-associated protein ZapE) (P64612)
Organism: Escherichia coli (strain K12)
Function: Reduces the stability of FtsZ polymers in the presence of ATP. Required for cell division under low-oxygen conditions. Hydrolyzes ATP but not GTP.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01919, ECO:0000269|PubMed:24595368}. Note=Localizes to the constricting Z-ring during late stages of the cell division process.
Interaction partners:
- Cell division protein ZapC
- Succinate dehydrogenase cytochrome b556 subunit
- Cell division protein ZapD
- Succinate dehydrogenase flavoprotein subunit
- Succinate dehydrogenase iron-sulfur subunit
- Cell division protein ZapA
Sequence:
MQSVTPTSQYLKALNEGSHQPDDVQKEAVSRLEIIYQELINSTPPAPRTSGLMARVGKLWGKREDTKHTPVRGLYMWGGVGRGKTWLMDLFYQSLPGERKQRLHFHRFMLRVHEELTALQGQTDPLEIIADRFKAETDVLCFDEFFVSDITDAMLLGGLMKALFARGITLVATSNIPPDELYRNGLQRARFLPAIDAIKQHCDVMNVDAGVDYRLRTLTQAHLWLSPLHDETRAQMDKLWLALAGGKRENSPTLEINHRPLATMGVENQTLAVSFTTLCVDARSQHDYIALSRLFHTVMLFDVPVMTRLMESEARRFIALVDEFYERHVKLVVSAEVPLYEIYQGDRLKFEFQRCLSRLQEMQSEEYLKREHLAG
Protein: Recoverin (Cancer-associated retinopathy protein) (Protein CAR) (P35243)
Organism: Homo sapiens (Human)
Function: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity).
Subcellular location: Photoreceptor inner segment {ECO:0000250|UniProtKB:P34057}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P34057}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon {ECO:0000250|UniProtKB:P34057}. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity). {ECO:0000250|UniProtKB:P21457, ECO:0000250|UniProtKB:P34057}.
Interaction partners:
- Rhodopsin kinase GRK1
- Rhodopsin kinase GRK7
- Rhodopsin
- S-arrestin
- Cone-rod homeobox protein
- Retinal guanylyl cyclase 1
- Amphiphysin
- Homeobox protein OTX2
- Voltage-gated potassium channel KCNC1
- Glutamate decarboxylase 2
Sequence:
MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDTDPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVMAIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANKEILRLIQFEPQKVKEKMKNA
Protein: Methanol--corrinoid protein co-methyltransferase (EC 2.1.1.90) (Methanol:corrinoid methyltransferase 1 subunit of 50 kDa) (MT1 subunit 50 kDa) (Q46EH3)
Organism: Methanosarcina barkeri (strain Fusaro / DSM 804)
Function: Methyltransferase involved in methanogenesis in the methanol pathway. Catalyzes the methylation of the MtaC-bound cob(I)amide.
Interaction partners:
- Methanol--corrinoid protein
- Methylcobamide:CoM methyltransferase MtaA
- Methanol-specific methylcobalamin: coenzyme M methyltransferase
- Methylcobalamin:coenzyme M methyltransferase
- Methanol corrinoid protein
- Methanol corrinoid protein
- Methanol:corrinoid methyltransferase
- Methanol:corrinoid methyltransferase
- Methylamine-specific methylcobalamin:coenzyme M methyltransferase
- Monomethylamine methyltransferase MtmB1
Sequence:
MAAKRYTSMAYANADEMTFGVSKYPVKAGLDLEIGAGYTIPEINYAPRPEAGASKEKLIKEYERITTDVMERMVQVGFPAIILETEHVQQMSNNPSWGAEVAHAQKTIMEKYHDEYGIKCALRHTIGDIRENREFLQLRGDKYSVFLEAFEQCAENGADLLSVESMGGKEVFDYAVLRNDIPGLLYSIGCLGSIDMELIWTDISKIAKKTGTISAGDTDCAQANTAMFIGGGLLNKNLAHTIAVIARAISAPRSLVAYEAGAVGPGKDCGYENIIVKAITGMPMTMEGKTSTCAHSDVMGNLVMQCCDCWSNESVEYHGEFGGTTVQCWSETLAYDCALMNTALETKNDKVLRDLMMLSDRYRDPQAYMLAYDNAYRVGQSIVKDGDNIYLRAKNAAIECCNIIEEGAAGKLELSRFETKALADAKAALEALPDDMDKFMDDCLTKYKSEVKVFKPENYGF
Protein: FA complementation group M (H0YJ14)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
IYNQSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKRFGHLALMFPMPSASAKRGAHGPQDLADYFGKESWDGSALEDSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI
Protein: Cyclin-dependent kinase E-1 (CDKE;1) (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin-dependent kinase 8) (Protein HUA ENHANCER 3) (Q84TI6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cell differentiation. Required for the specification of stamen and carpel identities and for the proper termination of stem cells in the floral meristem.
Subcellular location: Nucleus {ECO:0000269|PubMed:23229550}.
Interaction partners:
- Cyclin-C1-1
- Cyclin-C1-2
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 7b
Sequence:
MGDGSSSRSNSSNSTSEKPEWLQQYNLVGKIGEGTYGLVFLARTKTPPKRPIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLVNVHINFADMSLYLAFDYAEYDLYEIIRHHRDKVGHSLNTYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDAEEHGIVKIADFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGSKHYTSAVDMWAVGCIFAELLTLKPLFQGAEAKSSQNPFQLDQLDKIFKILGHPTMDKWPTLVNLPHWQNDVQHIQAHKYDSVGLHNVVHLNQKSPAYDLLSKMLEYDPLKRITASQALEHEYFRMDPLPGRNAFVASQPMEKNVNYPTRPVDTNTDFEGTTSINPPQAVAAGNVAGNMAGAHGMGSRSMPRPMVAHNMQRMQQSQGMMAYNFPAQAGLNPSVPLQQQRGMAQPHQQQQLRRKDPGMGMSGYAPPNKSRRL
Protein: Serine/threonine-protein phosphatase 2B catalytic subunit (EC 3.1.3.16) (Q12705)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Appears to be involved in cytokinesis, mating, transport, nuclear and spindle pole body positioning, and cell shape.
Interaction partners:
- Calcineurin subunit B
- Peptidyl-prolyl cis-trans isomerase
- Uncharacterized protein C13G6.15c
- Tyrosine-protein phosphatase pmp1
- Mitogen-activated protein kinase spm1
- Calcium-binding protein NCS-1
- Transcriptional regulator prz1
- Calmodulin
- Myosin 1 light chain cam2
- Protein phosphatase PP2A regulatory subunit A
Sequence:
MTSGPHNLEDPIVRAIRQKNQAPSHDFTIFVQEDGSSVSTLDRVVKNVQAPATYIPTDVEFFDINEPDKPDLHFLRNHFIREGRLSEEQTLYIIKKATEILKSEDNLIEVDAPVTVCGDIHGQYYDLMKLFEVGGNPANTQYLFLGDYVDRGYFSIECLLYLWALKIWYPKTLWLLRGNHECAHLTDYFTFKLECTHKYNIKVYEACLQSFNALPLAAIMNKQFLCVHGGLSPELHTLNDIRMINRFCEPPTHGLMCDLLWSDPLEDFGSEKSNKHFIHNNVRGCSYFYSYQAVCTFLENNNLLSVIRAHEAQDVGYRMYRKTKTTGFPSLMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVSEMLISMLNICSKEELYETDLKESAPTQHKQPAPSENENKADQEIDIEARRQIIKNKIMAIGRISRVFSVLREERESVSELKNVSGTQRLPAGTLMLGAEGIKNAINSFDDARKLDIQNERLPPSNSRRRSTDLKAFEEVMNSSEDDTSIDHLVERFADKKSSL
Protein: DNA-directed RNA polymerase I subunit RPA12 (DNA-directed RNA polymerase I 13.1 kDa polypeptide) (O94703)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Required for growth at higher temperatures.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P32529}.
Interaction partners:
- Probable DNA-directed RNA polymerase I subunit RPA2
- DNA-directed RNA polymerases I and III subunit RPAC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase I subunit rpa43
- DNA-directed RNA polymerase I subunit rpa49
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase I subunit rpa1
Sequence:
MSAIGSLIFCSECGNLLESTTAQWTTCDQCQSVYPSEQFANLVVETKSSASAFPSALKLKHSIVQVESQKEEAATIEEKCPKCGNDHMTFHTLQLRSADEGSTVFYECPRCAYKFSTNN
Protein: Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EC 6.1.1.24) (Glutamate--tRNA(Gln) ligase EARS2, mitochondrial) (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) (Mitochondrial glutamyl-tRNA synthetase) (mtGluRS) (Q9CXJ1)
Organism: Mus musculus (Mouse)
Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q5JPH6}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Bifunctional glutamate/proline--tRNA ligase
- Methionine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase
- Probable arginine--tRNA ligase, mitochondrial
- Isoleucine--tRNA ligase, mitochondrial
- Tyrosine--tRNA ligase, cytoplasmic
- Probable proline--tRNA ligase, mitochondrial
- Probable leucine--tRNA ligase, mitochondrial
- Asparaginyl-tRNA synthetase
Sequence:
MAAPLKRLLLAEPHVVALGHRVGRREASLGPDPGAPVRVRFAPSPTGFLHLGGLRTALYNYIFAKKHQGSFILRLEDTDQSRLVPGAAESIEDMLEWAGIPPDESPRRGGPAGPYCQSQRLALYAQATEALLRSGAAYPCFCLPQRLELLKKEALRSRQTPRYDNRCRNLSQAQVAQKLAVDPKPAIRFRLEEAVPAFQDLVYGWTQHEVASVEGDPVILKSDGFPTYHLACVVDDHHMSISHVLRGSEWLVSTSKHLLLYQALGWQPPRFAHLPLLLNRDGSKLSKRQGDIFLEHFAATGFLPEALLDIITNCGSGFAENQMGRTLPELITQFDLTRITCHSALLDLEKLPEFNRLHLRRLVSSETQRPQLVEKLQGLVKEAFGSELQNKDVLDPAYMERILLLRQGHISRLQDLVSPVYSYLWTRPAVHRSELGASSENVDVIAKRLLGLLERPGLSLTQDVLNRELKKLSEGLEGAKHSSVMKLLRMALSGQLQGPPVAEMMVSLGPKEVRERIQKVLSS
Protein: Cyclin N-terminal domain-containing protein 1 (Q9D995)
Organism: Mus musculus (Mouse)
Function: Plays a role in the different steps of crossover formation during meiotic recombination. Participates in the crossover differentiation step of crossover-specific recombination intermediates through its interaction with PRR19. In addition, stimulates crossover formation through the interactions with RFC3 and RFC4 and simultaneously regulates cell-cycle progression through interactions with CDC34 and subsequent ubiquitination of WEE1. May also participates in an active deselection process that destabilizes or removes excess pre-CO intermediates.
Subcellular location: Nucleus {ECO:0000269|PubMed:32640224}. Cytoplasm {ECO:0000269|PubMed:32640224}. Chromosome {ECO:0000269|PubMed:32555348}. Note=Shuttles between the nucleus and cytoplasm in a stage-specific manner of prophase I cells (PubMed:32640224). Co-localized at crossover sites with PRR19 (PubMed:32555348). {ECO:0000269|PubMed:32555348, ECO:0000269|PubMed:32640224}.
Interaction partners:
- Probable E3 SUMO-protein ligase RNF212
Sequence:
MNMEGPLRPRLVNCSDFQFGVVTTETIENALLHLAQQNEQAVKEAAGRTGSFRETRIVEFVFLLSEQWCLEKSVSYQAVEILERFMLKQAEDICRQATLQLRGKDTELQSWRAMKEQLVNKFILRLVSCVQLASKLSFHYKIVSNITVLNFLQALGYVHTKEELLESELDILKSLNFQINLPTPLAYVEMLLEVLGYNGCLVPATQLHATCLTLLDLVYLLHEPIYESLLRASIENSTPSQLQGEKFLSVKEDFMLLAVGIIAASAFIQNHECWSQVIGHLQSITGIASESIAEFSYAILTHSVGANTPGPQQPVPHKAARALRTAAAAASSNT
Protein: Biotin carboxyl carrier protein of acetyl-CoA carboxylase 1, chloroplastic (AtBCCP1) (BCCP-1) (Q42533)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:11299381, ECO:0000269|PubMed:18431481}.
Interaction partners:
- Biotin carboxylase, chloroplastic
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic
- NADH dehydrogenase 1 alpha subcomplex subunit 9
- Cytochrome c1 1, heme protein, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Cytochrome c1 2, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic
- EMBRYO DEFECTIVE 3147
- Beta-ketoacyl-[acyl-carrier-protein] synthase III, chloroplastic
Sequence:
MASSSFSVTSPAAAASVYAVTQTSSHFPIQNRSRRVSFRLSAKPKLRFLSKPSRSSYPVVKAQSNKVSTGASSNAAKVDGPSSAEGKEKNSLKESSASSPELATEESISEFLTQVTTLVKLVDSRDIVELQLKQLDCELVIRKKEALPQPQAPASYVMMQQPNQPSYAQQMAPPAAPAAAAPAPSTPASLPPPSPPTPAKSSLPTVKSPMAGTFYRSPAPGEPPFIKVGDKVQKGQVLCIVEAMKLMNEIESDHTGTVVDIVAEDGKPVSLDTPLFVVQP
Protein: Protein RALF-like 4 (Q9FZA0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Pollen-specific leucine-rich repeat extensin-like protein 1
- Leucine-rich repeat extensin-like protein 2
- Protein RALF-like 26
- Pollen-specific leucine-rich repeat extensin-like protein 4
- Calcium-dependent protein kinase 14
- Probable receptor-like protein kinase At2g21480
- At4g35700
- Armadillo repeat only 1
- Protein DMP9
- Proline-rich receptor-like protein kinase PERK5
Sequence:
MGVKMLLIFGLLILAMVAKSVNATYPLTKSCINGQGCIGEDDELESLMDSETNRRQLARGRRYIGYDALKKNNVPCSRRGRSYYDCKKRRRNNPYRRGCSAITHCYRYAR
Protein: Protein FAM193B (H0YCX2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XERSSCTSSSTHQRDGKFCDCCYCEFFGHNAPPAAPTSRNYTEIREKLRSRLTRRKEELPMKGGTLGGIPGEPAVDHRDVDELLEFINSTEPKVPNSARAAKRARHKLKKKEKEKAQLAAEALKQANRVSGSREPRPARERLLEWPDRELDRVNSFLSSRLQEIKNTVKDSIRASFSVCELSMDSNGFSKEGAAEPEPQSLPPSNLSGSSEQQPDINLDLSPLTLGSPQNHTLQAPGEPAPPWAEMRGPHPPWTEVRGPPPGIVPENGLVRRLNTVPNLSRVIWVKTPKPGYPSSEEPSSKEVPSCKQELPEPVSSGGKPQKGKRQGSQAKKSEASPAPRPPASLEVPSAKGQVAGPKQPGRVLELPKVGSCAEAGEGSRGSRPGPGWAGSPKTEKEKGSSWRNWPGEAKARPQEQESVQPSGPARPQSLPQGKGRSRRSRNKQEKPASSLDDVFLPKDMDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ
Protein: THO complex subunit 6 (Q9VTV1)
Organism: Drosophila melanogaster (Fruit fly)
Function: The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress.
Interaction partners:
- Hpr1
- THO complex subunit 2
- THO complex protein 7
- FI07663p
- THO complex subunit 5
- ATP-dependent RNA helicase WM6
- LD24793p
- Fl
- Protein Rae1
- LD31448p
Sequence:
MKQKDLKRAYNNVLAQAISGSKQYLFAGNLFGDIFVLRIKELDKGSEEPPGKLKIFPQGSDVDINYLAFHRDFLIVGAVGLIYGLEWNEEEESLATKRSWEVKIPMQVDAVEVPDVNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANGQIFSGAEDGTVRVWSTKQQQHTSMLEPYKNPNLLRPDWGKWIGAVAVNEDWLLCGGGPKASIFHLRSMESTCVFSFPGRVHLCDFVDDCVLIGGEHNHVQSYTLNGVLQANIPVEHTACYSAVWQTSPIKFISIAGFSNKLHILKDFRFLDSKIEMYGNVEGEENDPEEEDELIEKPLTVEAA
Protein: Irditoxin subunit B (IrTxB) (A0S865)
Organism: Boiga irregularis (Brown tree snake)
Function: This bird and reptile-specific postsynaptic neurotoxin inhibits the chick muscle alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND) nicotinic acetylcholine receptor (nAChR) 100-fold more compared with the mouse receptor. In vivo, produces rapid flaccid paralysis, dyspnea and increased respiratory rate in geckos. At sublethal doses geckos were immobilized for up to three days and then recovered. Chicks injected with lethal doses showed rapid onset of inactivity, dyspnea and neck droop, and no extended paralysis with survival was seen.
Subcellular location: Secreted {ECO:0000269|PubMed:18952712}.
Interaction partners:
Sequence:
MKTLLLAVAVVAFVCLGSADQLGLGRQQIDWGKGQAKGPPYTLCFECNRETCSNCFKDNRCPPYHRTCYTLYRPDGNGEMKWAVKGCAKTCPTAQPGESVQCCNTPKCNDY
Protein: Chalcone synthase (A4GXB5)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
IRDVGEVCKVQRAQGPATVWPIGTSTPPNCVDQSTYPDYYFRITNSEHKTELKEKFKRMCEKSMIKKRYMYLTEEILKENPNVCEYMAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRVAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGADPVPEIEKPMFELVSAAQTILPDSDGAIDGHL
Protein: Keratin-associated protein 5-8 (Keratin, ultra high-sulfur matrix protein B) (Keratin-associated protein 5.8) (UHS keratin B) (UHS KerB) (Ultrahigh sulfur keratin-associated protein 5.8) (O75690)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
Sequence:
MGCCGCSGGCGSGCGGCGSGCGGCGSSCCVPICCCKPVCCCVPACSCSSCGSCGGSKGGRGSCGGSKGDCGSCGGSKGGCGSCGCSQCSCYKPCCCSSGCGSSCCQSSCCKPCCSQSSCCKPCSCSSGCGSSCCQSSCCKPCCSQSSCCKPCCCSSGCGSSCCQSSCCKPCCSQSSCCVPICCQCKI
Protein: 26S proteasome regulatory subunit 6B homolog (O74894)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- Probable 26S proteasome subunit rpt4
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit rpn11
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit rpn8
- 26S proteasome regulatory subunit rpn7
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit rpn2
- 26S proteasome regulatory subunit rpn1
Sequence:
MNSTEEIDLYNRWKALERQLEMLDLQEGFIKEDCKSLKRELIRAQEEVKRIQSVPLVIGQFLEAIDQNTAIVGSTTGSNYVVRILSTLDRELLKPSASVALQRHSNALVDILPPEADSSISMLRPDERPDVSYADVGGLDVQKQEVREAVELPLTQGDLYRQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTAANFIRVVGSEFVQKYLGEGPRMVRDVFRMARENAPAIIFIDEIDAIATKRFDAQTGADREVQRILIELLTQMDGFDQGANVKVIMATNRADTLDPALLRPGRLDRKIEFPSYRDRRQRRLVFQTITAKMLLSPEVDLDTFIMRPDASSGAQIAAIMQDAGLLAVRKSRGVILQSDIEEAYARAVKPTDMEQFAFYK
Protein: Salivary gland secretion 1 (Q9VR49)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Salivary glue protein Sgs-4
- Salivary glue protein Sgs-5
- Salivary glue protein Sgs-3
- Ecdysone-induced gene 71Ee
- DNA topoisomerase 3-beta
- Sgs5bis
- Salivary glue protein Sgs-7
- GEO09046p1
- RecQ-like DNA helicase Blm
- DNA replication ATP-dependent helicase/nuclease
Sequence:
MKVALIFLTVSILLIQVKNVKANYDWDSMQDGPSEEIIPGCGGDTIYYPDPVQPCDTDSNPTTTKPRQKTKRPKSTRRTTKRTKRPRRKTTKWTTKRATKRTTKRTTRRRPTTPKTPDTTDSPITTTGAECTCSDRTTASSTDSTTDRTTVTNTDWTTPLCTDTPPCTCSEESSTAIPSSPCIDTSTVIPTSPCTQETTTPTPTCSTQGTQTTPCTCAQTTTTPRSTTTTSTSRPTTTTPRSTTTTTTSRPTTTTPRSTTTTTTRRPTTTTPRCTTTTSTCAPTTTTPRSTTTTTTSRPTTTTPRCTTTTSTCSPTRTTPRSTTTTSTSRPTTTTPRCTTTPSTSRPTTTTPRSTTKTSTCAPTTTTPRPTTTPSTSRPTTTTPRSTTTTSTSRPTTTTPRSTTTTTTRRPTTTTPRSTTTTSTSRPTTTTPRSTTTTTTSRPTTTTPRSTTTTCTCSPTTTTPRSTTTTSTSRPTTTTPRSTTTTSTSGPTTTTPRSTTTTTTSGPTTTTPRSTTTTCTCSPTTTTPRSTTTPSTSRPTTTTPRSTTTTCTCSPTTTTPRSTTTTSTSRPTTTTPRSTTTTTTSRPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSCPTTTTPRSTTTTCTSGPTTTTPRSTTTTCTSCPTTTTPRSTTTTCTSCPTTTTPRSTTTTCTSGPTTTTPRSTTKTSTCAPTTTTPRSTTTTSTSRPTTTTPRSTTTTTTSRPTTTTPRSTTTPSTSRPTTTTPRSTTTTSTSRPTTTTPRSTTKTSTCAPTTTTPRSTTTTTTSRPTTTTPRSTTTTTTSRPTTTTPRSTTTPCTSRPTTTTPRSTTTTTTSRPTTTTPRSTTTPCPTTTPSASPTRTTTTRRPCPCHPQPPYQIPPWSWWYPNPTYPNPVWPWQPNPVVPQWPQMPGYPNQWPQLPGYPQQLPPPLPSPQWPWSWPKPPVVQPGDCENICENLLKGVKYQEDLIRRCLCTRT
Protein: CG32611 (Q0EEE4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGSEHYCLRWNNYQSNLLGVFSQLLQDGSLVDVTLVCSEGTSIRAHKVVLSACSSYFQSLFLEHPEGHLIVILKDVRFAELQTLVEFMYKGEVNVQYCQLSALLKTAESLKVKGLAEMTNQNTTLREPEREPDRLRPQGGGGSGGSAHKAADSPAAALDATAATQAATATATATAAAATSTSTSATSAAATAAATAATSASTTATAAAGSSNTTTTTAATTTATCATAATSTSTAATSSSSSVTSAAAAAAAAASASGVAHSEEATSSSSSTGGQKREASDRSSPTPAKRSSRMHPADKVDVAEDREQEQNQADELLSEELLGRNLKDEEDDDVDELDENEETKLRGRDEDDDDEDEEDDTPMPLDLYQRPNVEPKSAAAATAAQQGGSNSLSGSSNACHTNSSSNSNNNNNNNNNSSSNNNNNTSSGKTSASSNGGTASSGGTADSVVAVDDDDDDDDGGHHHQRQVMDDRLEQDVDEEDLDDDVVVVGPATAMARGIAQRLAHQNLQRLHHTHHHAQHQHSQHHHPHSQHHHTPHHQQHHTHSDDEDAMPVIAKSEILDDDYDDEMDLEDDDEADNSSNDLGLNMKMGSGGAGGGGGVDLSTGSTLIPSPLITLPSSSAAAAAAAAAAMESQRSTPAMSAAQAAGAGASDLSIGGCGGRPASRSSRDGGGNDGGRGGASSSSLLSPGTVANLLPVQSVPLSLKKEIDCSEDDNSSHSRHMQQRSASAGGGLGGDLDYRASHESETSESPHQQQQPPPHAVGVGAGGGSAAAAAAAAAALLHQQQQQQPPHSPPPPPLHMFPCIYCRSAFPNQSKLTRHLLTHSLKTLEYREPTTTALLHSHLLGDLNMAAAGLPSPFAFQMNAAAMAATSGSDTQEQVAALAAAFGIDMEAALSLASTGCTFQSLTASCLEASSGGGSGGGGQGSLSRSATSAGNGGGLMLGSGSGSGSRAAAATGGSGSSGCGGGGGTATSGSLSPSTSAAAAAAAAAQSQSAALLGAASSDPNSVVMCDRPFKCEFCGKAFKLRHHMKDHCRVHTGERPFRCNMCGKTFSRSTILKAHEKTHFPKYVRKFLSPSSPVDTKDELPQ
Protein: Histone H1.4 (H1 VAR.2) (H1e) (P43274)
Organism: Mus musculus (Mouse)
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
Subcellular location: Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus. {ECO:0000250}.
Interaction partners:
- Chromobox protein homolog 5
- Histone H3.1
Sequence:
MSETAPAAPAAPAPAEKTPVKKKARKAAGGAKRKTSGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKRAGAAKAKKPAGAAKKPKKAAGTATAKKSTKKTPKKAKKPAAAAGAKKAKSPKKAKATKAKKAPKSPAKAKTVKPKAAKPKTSKPKAAKPKKTAAKKK