wanglab/gogpt-training-data huggingface dataset:
Protein: Glycogen synthase kinase-3 beta (EC 2.7.11.26) (Q9YH60)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Axin-2
- Casein kinase I isoform alpha
- Catenin beta-1
- Axin-1
- G1/S-specific cyclin-D1
- Tuberin
- APC regulator of WNT-signaling pathway
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
Sequence:
MSGRPRTTSFAESCKPVPQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELREPNVKLPNGREKPSLFNFTTQELSSNPTLASILIPAHARNQAGASTPTNPSATSDANSGDRSQTTTAASASASNTST
Protein: Leucyl/phenylalanyl-tRNA--protein transferase (EC 2.3.2.6) (L/F-transferase) (Leucyltransferase) (Phenyalanyltransferase) (P0A8P1)
Organism: Escherichia coli (strain K12)
Function: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
Subcellular location: Cytoplasm.
Interaction partners:
- ATP-dependent Clp protease adapter protein ClpS
Sequence:
MRLVQLSRHSIAFPSPEGALREPNGLLALGGDLSPARLLMAYQRGIFPWFSPGDPILWWSPDPRAVLWPESLHISRSMKRFHKRSPYRVTMNYAFGQVIEGCASDREEGTWITRGVVEAYHRLHELGHAHSIEVWREDELVGGMYGVAQGTLFCGESMFSRMENASKTALLVFCEEFIGHGGKLIDCQVLNDHTASLGACEIPRRDYLNYLNQMRLGRLPNNFWVPRCLFSPQE
Protein: Spermatogenesis-associated protein 20 (Sperm-specific protein 411) (Ssp411) (Transcript increased in spermiogenesis 78 protein) (Q80YT5)
Organism: Mus musculus (Mouse)
Function: May play a role in fertility regulation.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MSHHSSPPPKHKGEHKGHGLPRGSERGSSSRDKDRSATTVSSSAPMPAGGKSSRTNCPPPAPPKTVNRLINEKSPYLLQHAYNPVDWYPWGQEAFDKAKKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGRLLNENFICVMVDREERPDVDKVYMTFVQATSSGGGWPMNVWLTPGLQPFVGGTYFPPEDGLTRVGFRTVLMRICDQWKLNKNTLLENSQRVTTALLARSEISVGDRQIPASAATMNSRCFQQLDEGYDEEYGGFAEAPKFPTPVILNFLFSYWLSHRLTQDGSRAQQMALHTLKMMANGGIQDHVGQGFHRYSTDRQWHIPHFEKMLYDQAQLSVVYTQAFQISGDEFYADVAKGILQYVTRTLSHRSGGFYSAEDADSPPERGMKPQEGAYYVWTVKEVQQLLPEPVVGASEPLTSGQLLMKHYGLSEVGNINSSQDPNGELHGQNVLMVRYSLELTAARYGLEVEAVRALLNTGLEKLFQARKHRPKAHLDNKMLAAWNGLMVSGFAVTGAALGMEKLVAQATSGAKFLKRHMFDVSSGRLKRTCYAGTGGTVEQSNPPCWGFLEDYAFVVRGLLDLYEASQESSWLEWALRLQDTQDKLFWDPRGGGYFCSEAELGADLPLRLKDDQDGAEPSANSVSAHNLLRLHSFTGHKDWMDKCVCLLTAFSERMRRVPVALPEMVRTLSAQQQTLKQIVICGDPQAKDTKALLQCVHSIYVPNKVLILADGDPSSFLSRQLPFLSSLRRVEDRATVYIFENQACSMPITDPCELRKLLHQ
Protein: BZIP domain-containing protein (A7RXL3)
Organism: Nematostella vectensis (Starlet sea anemone)
Interaction partners:
Sequence:
MLTADFSMTLSNFGRRSWVVPVPLGYALTSLARFLLSFRIDLRSSRSPSFVANFLESLRLRWALCLASPISLRETPSSATPIQPGGGFGDGLGCGLWNQVLQGGSFFDQVAELEKSLVENHNTGIEGQGVKFRRPQGTRSHENLPLSPIQNSEFSMWNQSDTFAGQHEGCSGDGTCPGSLLPVKSENLDDYWSMDKEEIIITGIPRQESGLDLLVPSPSSSSGDSDKSEEKRKRNNQASKKFRQARKGKQQALFAKESELERENYSLKVQVEQLIRELNQLKAALHGGSK
Protein: Exocrine gland secreted peptide 36 (Exocrine gland-secreting peptide 36) (A8R0W9)
Organism: Mus musculus (Mouse)
Interaction partners:
- Olfactory receptor 5T7
Sequence:
MMFFILTLPLPSMLTEGRVLPETQKEPKISADHKTNGNIVFEEIDCKNMRINIEDVGHNLQGSYQINIQFQGLFNDFLLNTCSSVSQTTNTMFIIETMNIEIFTRMSNSWNSIRHKT
Protein: Selenocysteine lyase (EC 4.4.1.16) (H7C3V9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
Sequence:
VSGQAEVDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQERVAAGLPPILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPRIGALYIRGLGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQKRIHLNSQFPGTQRLPNTCNFSIRGPRLQGHVVLAQCRVLMASVGAACHSDHGDHSSCSSVSPSPGRPQCC
Protein: Seripauperin-17 (Q12370)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Seripauperin-23
- Seripauperin-24
- Seripauperin-2
- Seripauperin-15
- Probable electron transfer flavoprotein subunit alpha, mitochondrial
- Probable electron transfer flavoprotein subunit beta
- Seripauperin-3
- Seripauperin-16
Sequence:
MVKLTSIAAGVAAIAAGVAAAPATTTLSPSDERVNLVELGVYVSDIRAHLAEYYMFQAAHPTETYPVEIAEAVFNYGDFTTMLTGIPADQVTRVITGVPWYSTRLRPAISSALSADGIYTAVPN
Protein: Craniofacial development protein 1 (27 kDa craniofacial protein) (Bucentaur) (Protein Cp27) (O88271)
Organism: Mus musculus (Mouse)
Function: May play a role during embryogenesis. May modulate tooth organogenesis since alterations of this protein function affect tooth organs size as well as individual cell fate and survival. In embryonic cells, blockage of the function results in increased number of apoptotic cells, reduced proliferation, alterations in cell shape and fibronection matrix synthesis.
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9UEE9}.
Interaction partners:
- RuvB-like 1
- DNA methyltransferase 1-associated protein 1
- RuvB-like 2
- E1A-binding protein p400
- Snf2-related CREBBP activator protein
- Transmembrane protein 170A
- Actin-related protein 6
- Zinc finger HIT domain-containing protein 1
- Histone H2A.Z
- Vacuolar protein sorting-associated protein 72 homolog
Sequence:
MEEFDSEDFSTSDEDEDYLPSGGEYSEDDVNELVKEDEVDGEEQAEKTKGKRRKAQGIPARKRKQSGLLLEEEEDGKEDSGGSSSEEDEEEQEGGLGSENARKKKEDELWASFLNDVGPKSKAAPGSQTKVAEETEEISSNKPLVKADELDKPRESEKVKITKVFDFAGEEVRVTKEVDAASKEAKSFLKQTEREKPQALVTSPATPLPAGSGIKRASGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP
Protein: Peptide ABC transporter, peptide-binding protein (E8PQ06)
Organism: Thermus scotoductus (strain ATCC 700910 / SA-01)
Interaction partners:
- Oligopeptide transport system permease protein AppB
- Oligopeptide transport system permease protein AppC
- Pyruvate:ferredoxin
- ABC-transport protein, solute-binding component
Sequence:
MRKVGKLAVFGLAALGLALAGPQDNSLVIGASQEPRVLAGDFLSIISNQSIKLEIEQYLFAPLIGFNANSENFPVLVTEVPTRQNGRLRVTDIGGGKKRLEMDLTIRPDARWSDGKPITTEDVAFYYEVGKAKGMPVLNPDYWERVNLRVRDARNFTVIFEPAYYYDTYGGTYGSPIGYAPKHIMGAEWEKVKAAARNLDPDKDAERLNELYRNFFLKFATPQALNRGAMVYSGAFKLRRWVPGNSIEMERNPNFPIKPEGGESRYVQRVVYRFIQNTNSLLVAVLGGSIDATSSVSLTFDQGRSRQLTSRAPGRFDIWFVPGAIWEHIDVNKFENCQAVRDLGLNDVRTRRALLHALNREGLVKAFFDGLQPVAHTWIAPVNPLFNPNVRKYEFDLKKAEALLAEMGWRKGPDGILQRTVGGRTVRFEIEFVTTAGNAIRERTQQFFAEDLKKIGIAVKINNAPSAVVFADDYIQRASECKWTGLFEFAWVSNLAEDGSLFQYKNLNTGAIMVPTKENNYQGQNIGGWRNDEFDRLTSQGVLEFDEARRKQLFWRAQEIWAEELPALPLYFRANPYVVRKGLVNYVASAYAGGYGYPGWNAWEIGWESRGAVKKWDQAKYALSVK
Protein: Meiotically up-regulated gene 99 protein, mitochondrial (Q9P6M7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for correct meiotic chromosome segregation. Appears to also have role in sporulation.
Subcellular location: Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLRFGIKTWKRSVLAIRRSSTAPHVQIISNLQKKLLNELYSLRRLVDDNSPATIRVGNVSLLLSKSNIRRRIALQALSSSAEDVACVKQITHALLAAPFMPESKELKYAMDHNGLNPLYISFGTNALFERNARYSTSHLFLPSDFLQVNNLEIIHLPPGTVDSDILASCHARYICSTSYLRMTSSDFTTADTLVLDIDPKLHSLLKNEKSIIPVSSSAALKATKALQDDPHNFQNYQNQWEQSGFQQLRTNMTPTSDLEICKRFLNYLCCSFSLTKAEKDLVRATEFSNSMLISIEKWAKYCDVDLQEFEKKLQKFWKNFGTLKLYSNIESLPASLKQLIKDEYLQKSKLELSFILGELSKNGDDKNNFELAMKDFGTFQNSRMSAVDQALQPLRRKTLYTTAFQGLGALGSLYLYFVSHFSLYNAFSVFSVCGVFGLYYLQSSYRSWKKEYWKELLEEGRKFERQLCRNVFGRSSFYVQQKTAAEKKEHISLIMKKLTKTLDLMKEFQLQSSFSDSPTASKKQLL
Protein: Ras-related protein Rab-15 (EC 3.6.5.2) (Q8K386)
Organism: Mus musculus (Mouse)
Function: May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal. EHBP1L1.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- EF-hand calcium-binding domain-containing protein 4B
- EF-hand calcium-binding domain-containing protein 4A
Sequence:
MAKQYDVLFRLLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVDFKMKTIDVDGIKVRIQIWDTAGQERYQTITKQYYRRAQGIFLVYDISSERSYQHIMKWVSDVDEYAPEGVQKILIGNKADEEQKRQVGREQGQQLAKEYGMDFYETSACTNLNIKESFTRLTELVLQAHRKELDGLRTRASNELALAELEEDEGKPEGPANSSKTCWC
Protein: Coiled-coil domain-containing protein 141 (Q8BLW1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSCKESPHVGASTTTVSSVAVHAGDSKIVIAVVKCGKWVRLQLAESQPNLLEIGSSQDETKKLLHDHELLLAKLKALEDRVWELLREADRTAEANKAQSQVYDAMAQTLGEAWATLVSMLERRRELLGLTSEFFQSALEFAIKIDQAEAFLQNPHEFESTEALQSLLLLHDRHAKELLERSLDLLNKSQQLTDFIEKFKCEGSTMNSELIQGAQSSCLKIDSLLELLQDRRRQLDKYLQQQRQELSQVLQLCLWDQQENQVSSWFQKAIRDLQEQSLGASLSDNRELICKHEDLIVKAKSFDVLGKVEAYLKLLKSEGLSLPVLAAKHEELHREIKDSTATALQKGRTLISQVDSCRSRVTGIHEMMGYIQNRVDCLTEQCTAHEEFARKRQQLATSVDDYLRKVEMSIQEIRPILATTLDVASSPSESEKILNKYLELDIQVKETAHALEAAAKIMTEKNELELNEVALLPLKVKWLEEELSTLGRSISCRSRILQTYVAFRKSSEEAEEQLQSLKEFYLTEIPWKDEDDAVVKCQSNSAERKWQLFLKKSFLTQDLSLEFLNLINMAKENEILNVKNEMHIMENIMEKQTNGREELSHLRVAWYLKAIEGKPAREQWEMFKEKLTKVRKRAGQWLGAKHSIVKHWVWTLARKQTKRHAEWYFSKNIFWSVQCDRAFKPRGKRNQPSTKVQESHGSVYLQPCSQIQKQRSEWMLPEDAGREEGTGCC
Protein: General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha) (P29083)
Organism: Homo sapiens (Human)
Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Subcellular location: Nucleus {ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:7651391}.
Interaction partners:
- Transcription initiation factor IIB
- General transcription factor IIH subunit 1
- General transcription factor IIF subunit 1
- General transcription and DNA repair factor IIH helicase subunit XPD
- TATA-box-binding protein
- Transcription initiation factor IIE subunit beta
- General transcription factor IIF subunit 2
- General transcription factor IIH subunit 4
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MADPDVLTEVPAALKRLAKYVIRGFYGIEHALALDILIRNSCVKEEDMLELLKFDRKQLRSVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDHMRRRIETDERDSTNRASFKCPVCSSTFTDLEANQLFDPMTGTFRCTFCHTEVEEDESAMPKKDARTLLARFNEQIEPIYALLRETEDVNLAYEILEPEPTEIPALKQSKDHAATTAGAASLAGGHHREAWATKGPSYEDLYTQNVVINMDDQEDLHRASLEGKSAKERPIWLRESTVQGAYGSEDMKEGGIDMDAFQEREEGHAGPDDNEEVMRALLIHEKKTSSAMAGSVGAAAPVTAANGSDSESETSESDDDSPPRPAAVAVHKREEDEEEDDEFEEVADDPIVMVAGRPFSYSEVSQRPELVAQMTPEEKEAYIAMGQRMFEDLFE
Protein: Tumor necrosis factor receptor superfamily member 1A precursor (Tumor necrosis factor receptor superfamily, member 1a) (Q6NUU6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRICQLTTCLFLVLTSQLYTISGLGGNKTMKGNCLENEYWNKEGFCCDKCHQGYKLKQECSAENMRSKCEKCDEGTYLEQANYSPNCFRCQQCTKPHSRESSPCTPYSNRVCECDTDYYKKKLGDLGWECSRCKKCGDGQIEIQNCTKEENRQCKCQENHYPFNKNSCKLCDKCQPGCDHLCKTSIPPVFFTSTKSNSPEDTVPKIVVPVCASIMVLSLAIFMAYEGIRHWRKRAQASSSQSSSPATEEEAFIITVVQDSKNKSVSFTNQPCESKPLGNLPDCIPREIKIHEFFYFVLDEVPIGRFKELVRRLGVSEQNIDRAEHDHRNCKDAQYQMLKVWSDGGSGGGNNVVPYDQIQMLMSTLKDMCLVSCADNIENKFLSQNTSVS
Protein: U20-myrmicitoxin-Mri1a (U20-MYRTX-Mri1a) (A0A6G9KIR5)
Organism: Manica rubida (European giant red ant)
Function: Induces paralysis 5 minutes after injection into blowflies (L.caesar), and then death within 24 hours. May have antimicrobial properties, like most ant linear peptides (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:32182430}.
Interaction partners:
Sequence:
MKSVILLFAVIAIIVAVIIPAINGESSSNPSANAGIMESLKQLSAKAEELIKKLLAKKAK
Protein: Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2) (P63026)
Organism: Bos taurus (Bovine)
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P63027}; Single-pass type IV membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P63045}. Note=Colocalizes with PRKCZ and WDFY2 in intracellular vesicles. {ECO:0000250|UniProtKB:P63027}.
Interaction partners:
- Syntaxin-1B
- Syntaxin-1A
- Synaptosomal-associated protein 25
- Synaptosomal-associated protein
- Syntaxin-4
- Syntaxin-binding protein 1
- Synaptotagmin-1
- Syntaxin-3
- Alpha-soluble NSF attachment protein
- Syntaxin 2
Sequence:
MSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFSS
Protein: Calcium binding protein 39 (D3ZJ77)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLRECIRHEPLAKIILWSEQFYDFFRYVEMSTFDIASDAFATFKDLLTRHKLLSAEFLEQHYDRFFSEYEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQTKLIEFLSKFQNDRTEDEQFNDEKTYLVKQIRDLKRAAQQEA
Protein: Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 2) (DAHP synthase 2) (Phospho-2-keto-3-deoxyheptonate aldolase 2) (Q00218)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- 3-dehydroquinate synthase, chloroplastic
- Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic
- 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic
- Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic
- Phospho-2-dehydro-3-deoxyheptonate aldolase
- Shikimate kinase 2, chloroplastic
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Chorismate mutase 1, chloroplastic
- Chorismate mutase 2
- Shikimate kinase 1, chloroplastic
Sequence:
MVTLNASSPLTTKSFLPYRHAPRRPISFSPVFAVHSTDPKKSTQSASASVKWSLESWKSKKALQLPDYPDQKDVDSVLQTLSSFPPIVFAGEARKLEDKLGQAAMGQAFMLQGGDCAESFKEFNANNIRDTFRVLLQMGVVLMFGGQLPVIKVGRMAGQFAKPRSDPFEEKDGVKLPSYRGDNINGDAFDEKSRIPDPHRMVRAYTQSVATLNLLRAFATGGYAAMQRVSQWNLDFTQHSEQGDRYRELANRVDEALGFMGAAGLTSAHPIMTTTEFWTSHECLLLPYEQALTREDSTSGLYYDCSAHMLWVGERTRQLDGAHVEFLRGIANPLGIKVSDKMVPSELVKLIEILNPQNKPGRITVIVRMGAENMRVKLPNLIRAVRGAGQIVTWVSDPMHGNTIMAPGGLKTRSFDAIRAELRAFFDVHDQEGSFPGGVHLEMTGQNVTECVGGSRTITYNDLSSRYHTHCDPRLNASQSLELAFIIAERLRKRRLGSGNLPSSIGV
Protein: TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor) (Q9UNN4)
Organism: Homo sapiens (Human)
Function: May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:16525715}. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.
Interaction partners:
- Transcription initiation factor IIA subunit 2
- Stonin-1
- TATA-box-binding protein
- Transcription initiation factor IIA subunit 1
- Transcription initiation factor IIB
- TATA box-binding protein-like 1
- TATA box-binding protein-like 2
Sequence:
MACLNPVPKLYRSVIEDVIEGVRNLFAEEGIEEQVLKDLKQLWETKVLQSKATEDFFRNSIQSPLFTLQLPHSLHQTLQSSTASLVIPAGRTLPSFTTAELGTSNSSANFTFPGYPIHVPAGVTLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQLNPWSLQATTEKSQRIETVLQQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALLCHQESSHYISLPGVVFSPQVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLHILKNRMYGCDSVKQPRNIEEPSNIPVSEKDSNSQVDLSIRVTDDDIGEIIQVDGSGDTSSNEEIGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPLNSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDAEW
Protein: G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (C-JUN leucine zipper interactive protein JZA-3) (Thymine-DNA glycosylase) (P56581)
Organism: Mus musculus (Mouse)
Function: DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Growth arrest and DNA damage-inducible protein GADD45 alpha
- Small ubiquitin-related modifier 1
- Histone lysine acetyltransferase CREBBP
- Single-strand selective monofunctional uracil DNA glycosylase
- DNA
- DNA
- Uracil-DNA glycosylase
- Methylcytosine dioxygenase TET1
- N-glycosylase/DNA lyase
- SUMO-conjugating enzyme UBC9
Sequence:
MDAEAARSYSLEQVQALYSFPFQQMMAEVPNMAVTTGQQVPAVAPNMATVTEQQVPEDAPVQEPAPEAPKRRKRKPRAAEPQEPVEPKKPATSKKSGKSTKSKEKQEKITDAFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNADVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCNGEPCGIASNGLTAHSAEPRGEAAPSDVPNGQWMAQSFAEQIPSFNNCGTREQEEESHA
Protein: F-box protein At5g67140 (Q9FH99)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDEEAAIDRLPLDLLAYIFSLATSFTVLAQASGVCKKWRKAVNQSMARRETLSFAGWKMDDDSTSRLVHLAFNLKELDISRSRWGCHITDNGLYQIASARCVSNLNSVSLWGMTAITDSGVVQLISRTSSLQHLNIGGTFITDESLFAIAERCHQLKTIGMWCCRHVTERGLLVLVNKCRKLESINLWGTRVPVDCFIALLTISPALQIKPMELLLNAQNPPPLLHAV
Protein: Ribosome biogenesis protein NSA2 homolog (Q38AJ3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU367114}.
Interaction partners:
- Large ribosomal subunit protein eL18
- 60S ribosomal protein L17, putative
- Ribosome assembly factor mrt4
- 60S ribosomal subunit protein L31, putative
- Nucleolar GTP-binding protein 1
- 60S ribosomal protein L24, putative
- Nucleolar GTP-binding protein 2
- Pescadillo homolog
- 60S ribosomal protein L35, putative
- Ribosome biogenesis protein BOP1 homolog
Sequence:
MPQNEYIELAQKRYGRRLDHAERMRKRNARKVHTEAKRLRTVRGIKAKIAAKERYAEKAEIRKKIREHEEKQTTERVKEKGPKNALPSFLMDRSEADRAKVLSNSLKQKRKEKAGKWAVPIEKVKPVSEDEMLRAVTSGKRGKKSWKRMVNKVTFVGETFTRRLPKYERFIRPMALRFKKAHVTHPELKATFQLPIIGVKKNPQGKMYTGLGVITKGTVIEVNVSDLGLVTPSGKVVWGKYAQVTNNPENDGCINAVLLV
Protein: Pentatricopeptide repeat-containing protein At4g11690 (Q9T0D6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cysteine/Histidine-rich C1 domain family protein
- RNA helicase
Sequence:
MAAKSQKTLVLLANLIKFPPLKAFSLLNSPNFHEFQHTHESISILLRLLLSGNLFSHAQSLLLQVISGKIHSQFFTSSSLLHYLTESETSKTKFRLYEVIINSYVQSQSLNLSISYFNEMVDNGFVPGSNCFNYLLTFVVGSSSFNQWWSFFNENKSKVVLDVYSFGILIKGCCEAGEIEKSFDLLIELTEFGFSPNVVIYTTLIDGCCKKGEIEKAKDLFFEMGKLGLVANERTYTVLINGLFKNGVKKQGFEMYEKMQEDGVFPNLYTYNCVMNQLCKDGRTKDAFQVFDEMRERGVSCNIVTYNTLIGGLCREMKLNEANKVVDQMKSDGINPNLITYNTLIDGFCGVGKLGKALSLCRDLKSRGLSPSLVTYNILVSGFCRKGDTSGAAKMVKEMEERGIKPSKVTYTILIDTFARSDNMEKAIQLRLSMEELGLVPDVHTYSVLIHGFCIKGQMNEASRLFKSMVEKNCEPNEVIYNTMILGYCKEGSSYRALKLLKEMEEKELAPNVASYRYMIEVLCKERKSKEAERLVEKMIDSGIDPSTSILSLISRAKNDSHVSSK
Protein: Ribosome-inactivating protein PD-L1/PD-L2 (EC 3.2.2.22) (rRNA N-glycosidase PD-L1/PD-L2) (P84853)
Organism: Phytolacca dioica (Bella sombra tree) (Phytolacca arborea)
Function: Inhibits protein synthesis. Has adenine polynucleotide glycosidase activity on herring sperm (hs)DNA and poly(A) substrates. Cleaves supercoiled pBR322 dsDNA.
Interaction partners:
Sequence:
INTITYDAGNTTINKYATFMESLRNEAKDPSLQCYGIPMLPNNSSTIKYLLVKLQGASQKTITLMLRRNNLYVMGYSDPFNGNCRYHIFNDITGTERTNVENTLCSSSSSRDAKPINYNSLYSTLEKKAEVNSRSQVQLGIQILSSDIGKISGQSSFTDKTEAKFLLVAIQMVSEAARFKYIENQVKTNFNRDFSPNDKILDLEENWGKISTAIHDATNGALPKPLELKNADGTKWIVLRVDEIKPDMGLLNYVNGTCQTT
Protein: G protein-coupled receptor 35 (G3V962)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- C-X-C motif chemokine ligand 17
- Indoleamine 2,3-dioxygenase 2
Sequence:
MNNTNCSILPWPAAVNHVFTIYLVLLLVLGLLLNGLALWVFCYRMHQWTETRVYMTNLAVADVCLLCSLPFVLYSLKYSTSDTPICQLSQGIYLVNRYMSISLVTAIAVDRYVAVRHPLRARELRSPRQAGAVCVALWVIVVTSLVLRWRLGIQEGGFCFSSQNRYNFSTTAFSLLGFYLPLAIVVFCSLQVVTALARRPATDVGQVEATQKATRMVWANLAVFIICFLPLHLILTVQVSLNLHTCAARNIFSRALTITAKLSDINCCLDAICYYYMAKEFQDASLPATASSTPHKSQDTQSLSLT
Protein: Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) (Q17860)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Regulator of G-protein signaling 7
- Guanine nucleotide-binding protein subunit alpha
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
- Phorbol ester/diacylglycerol-binding protein unc-13
- Regulator of G-protein signaling egl-10
Sequence:
MAAEGHNVDANLVDMRPNHGHYFVKKTFGKPAYCHHCCDKIWGMLTTGYSCEMCNFVCHEKCLRTVVSYCSSVALQLIKNPVAHTWSAPCLIKRKYCCVCRKRTDDALSVECEVCEYYVHVDCSDLAVSDCKEAATYVANMESANTVQYHHMREGNLPKESKCIVCRKTCFSTECLAGMRCEWCGQTAHAVCYRQMDKECDFGVLRKIMLPPMCLTIPRTELPMEQLLNISSHDQPQSRKVSSPSKIQADDVSTSGEDVKEREDFEIIRVFDGNNSYRSQISRNIVVAKHVSVQQVRDAALRRFHINDTPERYYITQVVGEVEEEILEDPVPLRNVKRPEGKRAQIFIRYYDDPDKDEVKVYGGWLRKVPVTFCAISVSKDTVVQDLVTDALYHFGLDGSCWNRYNLIEVSLDRGVAERTCNPQENVLQLVRNLRKDSLRRYHVVRFYVQEKEDPHDHAVFVGNLPVSLAQRQYERILLKLLGAKEKPFTAIGPIYFEYGSLIITFNTPKAATAAVQKLQSAIYEEKKLIVLCLPNVQPQMIPKDVEPLLVLVNVKSGGCQGTELIQSFRKLLNPFQVFDVLNGGPLVGLYVFRNIPKYKILACGGDGTIGWVLQCLDIAKQDAACFSPPCGIVPLGTGNDLARVLRWGGGYTGEENPMDILKDVIEADTVKLDRWAVVFHEEERNQPTSSGNQTEMNEQTMNNPEDQTSMIIMNNYFGIGIDADVCLKFHNKRDANPEKFQSRLFNKTQYAKIGLQKMFFERTCKDLWKRIELEVDGRIIELPNIEGIVVLNLLSWGSGANPWGTSKEEGNFSKPTHYDGLLEVVGISDVSRLGLIQSKLAAGIRIAQGGSIRITTHEEWPVQVDGEPHIQPPGTITILKSALKAQMLKKAKKSRRGGATNATSLTHPHPETSESMSGPLGVPSTLGDPNHGKTTPDNTAADSDEEGDAFL
Protein: Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Protein BLUE LIGHT-DEPENDENT H(+)-ATPASE PHOSPHORYLATION) (Q93Z30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:28358053}.
Interaction partners:
- Protein kinase family protein
Sequence:
MEEDYQQPRFTIGRQSSMAPEKIPEPSVHSEEEVFEDGEEIDGGVRLMYLANEGDIEGIKELIDSGIDANYRDIDDRTALHVAACQGLKDVVELLLDRKAEVDPKDRWGSTPFADAIFYKNIDVIKILEIHGAKHPMAPMHVKTAREVPEYEINPSELDFTQSKEITKGTYCMAMWRGIQVAVKKLDDEVLSDDDQVRKFHDELALLQRLRHPNIVQFLGAVTQSNPMMIVTEYLPRGDLRELLKRKGQLKPATAVRYALDIARGMSYLHEIKGDPIIHRDLEPSNILRDDSGHLKVADFGVSKLVTVKEDKPFTCQDISCRYIAPEVFTSEEYDTKADVFSFALIVQEMIEGRMPFAEKEDSEASEAYAGKHRPLFKAPSKNYPHGLKTLIEECWHEKPAKRPTFREIIKRLESILHHMGHKRQWRMRPLTCFQNFEHKKKHNWDLSSHDGSSSGSHL