wanglab/gogpt-training-data huggingface dataset:
Protein: Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) (P9WFV3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Leucine--tRNA ligase
- Arginine--tRNA ligase
- Proline--tRNA ligase
- Glutamate--tRNA ligase
- Phenylalanine--tRNA ligase beta subunit
- Methionine--tRNA ligase
- Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX
- Threonine--tRNA ligase
- Lysine--tRNA ligase 1
- Tyrosine--tRNA ligase
Sequence:
MTDNAYPKLAGGAPDLPALELEVLDYWSRDDTFRASIARRDGAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQLGITDKSQIEAMGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTVGFKVVGGQPDNGLDGAYLLVWTTTPWTLPSNLAVAVSPDITYVQVQAGDRRFVLAEARLAAYARELGEEPVVLGTYRGAELLGTRYLPPFAYFMDWPNAFQVLAGDFVTTDDGTGIVHMAPAYGEDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSGPAAVNGPVLIRHETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEHVKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDELERDFGVRPANLHRPYIDELTRPNPDDPTGRSTMRRIPDVLDVWFDSGSMPYAQVHYPFENLDWFQGHYPGDFIVEYIGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFLMASPILRGGNLIVTEQGIRDGVRQVLLPLWNTYSFLALYAPKVGTWRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEALTNWYVRRSRSRFWAEDADAIDTLHTVLEVTTRLAAPLLPLITEIIWRGLTRERSVHLTDWPAPDLLPSDADLVAAMDQVRDVCSAASSLRKAKKLRVRLPLPKLIVAVENPQLLRPFVDLIGDELNVKQVELTDAIDTYGRFELTVNARVAGPRLGKDVQAAIKAVKAGDGVINPDGTLLAGPAVLTPDEYNSRLVAADPESTAALPDGAGLVVLDGTVTAELEAEGWAKDRIRELQELRKSTGLDVSDRIRVVMSVPAEREDWARTHRDLIAGEILATDFEFADLADGVAIGDGVRVSIEKT
Protein: Catalase-peroxidase (CP) (EC 1.11.1.21) (Peroxidase/catalase) (Q96VT4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
Subcellular location: Cytoplasm. Note=Found in sexual structures such as Huelle cells, but not in primordia, hyphae and conidiophores.
Interaction partners:
- Aspartate aminotransferase
- Aromatic-L-amino-acid decarboxylase, putative
- histidinol-phosphate transaminase
- Kynureninase 2
- Kynureninase 1
- Aspartate aminotransferase
- aspartate transaminase
- Aromatic-amino-acid transaminase, hypothetical
- aromatic-amino-acid transaminase
- Phenylalanine ammonia-lyase
Sequence:
MGSNECPYSRQNANIGGGGQNNRDWWPDDLKLNILRQHNSVSNPLDKGFDYTAAFNSLDYFGLKRDLEALMTDSQDWWPADFGHYGGLFIRMAWHSAGTYRVFDGRGGGGQGQQRFAPLNSWPDNVSLDKARRLLWPIKQKYGSKISWADLLILAGNVALESMGFKTFGFAGGRSDTWEADQSVFWGGEKEWLGNDVRYLNGELDNPLAASHMGLIYVNPEGPNKNPDPVLAAKDIRITFGRMAMNDEETVALIAGGHTFGKTHGAGPATHLGKEPHGAGIELQGLGWESGFESGTGRHAITSGLEVIWTKTPTKWSNQFFEYLFKYDWELTKSPAGAHQYVAKGVEPFIPDPFDPSIKHPPRMLTTDLSLRYDPEYEKISRRFLENPDQFADAFARAWFKLTHRDVGPRVLYQGPEVPSEVLIWQDPVPPLDHPVIDNDDIATLKKAILNSGISHTDLFSTAWASASTFRGSDKRGGANGARIRLSPQKNWKVNSQPWLSESLAALEKIQKQFNDAQSTDKRVSLADLIVLAGAASLEKAARDAGHNVSVSFTPGRTDATQEQTDVDSFNNLEPIADGFRNYGRGTPRVLTEDFLIDKAQLLNLSPPELTVLIGGLRVLNNNYDRSNLGVFTKRPGQLTNDFFVNLLDMGVQWKPADDTNEIFIGSDRKTGQARWKASRADLVFGSHAELRAISEVYGSSDGEAKFVKDFVAAWEKVSNLDRFDLKQTGLAQRIKPQL
Protein: ARM repeat superfamily protein (F4IXH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome regulatory subunit RPN13
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome non-ATPase regulatory subunit 12 homolog A
- 26S proteasome non-ATPase regulatory subunit 12 homolog B
- 26S proteasome non-ATPase regulatory subunit 7 homolog B
- 26S proteasome non-ATPase regulatory subunit 1 homolog A
Sequence:
MEDVNQLFDAAFEFAHYPGAQNETSVKEFLDRFPLPVIFNALQTDPDIPGFENTLVTCLERLFKTKYGASLIPQYMPVLQVGLKADSAVVKSLACKTVLCLLEDCDTNDVSSVQLVVNNGIYPLLLDYIINSDDEVANAASETIKSLARFPDAMSVIFPSETNDPTHLRNLAARCSSLARVRVLSLIVKLFSISRLVASEVKKSGLLDLLEAEMKGTKDTLVILNVLELYYELMEVEHSSEFVPQTSLIQLLCSIISGTSTGPYEKLRAMMISGRLLSKENIYKVVEEARPVVPCLKASVCCAHKTSDEVEKLTTNCFVSECVKALISAIDGSLESVEMNDTDAQEAAIDALGQMGSTTKGADLVLSTSPPAARHVVASAFDRNAHGKQLAALHALANIAGETRPKSNRIVDGKAEESLRCLIYDAAAQSTKLTPSGLFLSVLQQSSEIRLAGYRTLTALVARPWCLVEILAKEEIINIVTDATTETAKIAMEARYNCCKAIHEAFLCSNFVDDPRRLKTGDKLQEAVRSGPYMSKKHRGARPEVMTGEGF
Protein: Pyrin domain-containing protein 5 (Pyrin domain-only protein 3) (W6CW81)
Organism: Homo sapiens (Human)
Function: Functions as an inhibitor of DNA virus-induced activation of AIM2-like receptors (ALR) inflammasome through interaction with AIM2.
Interaction partners:
Sequence:
MESKYKEILLLTSLDNITDEELDRFKCFLPDEFNIATGKLHTLNSTSSQLDLKRWHGVCSEEDRIFQKLNYMLVAKCLREEQETGICGSPSSARSVSQSRLGLSFHGISGNAC
Protein: Probable alpha-1,2-galactosyltransferase gmh2 (EC 2.4.1.-) (Q09681)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein C5H10.12c
- Uncharacterized protein C4C3.09
- Meiotically up-regulated gene 136 protein
- Small ribosomal subunit protein eS1A
- Uncharacterized permease C1683.05
Sequence:
MALMLSRIPRRFFFLFLTVGLIAGAFLYSLIYFVDVDLVSKVNQLYDQQIAPMLSDAIGTPSVNHSFELAPLDSHLVATSTTFHEASYESEPQQNPASQNIVLLLVSDGHTSYNNGANTFEEAIQNRVDYSTKQNYNFEYVNVTGLPIPAVWSKMPAVLQTMKKYPKAEWIWLLDQDAIITNTHLSLQDSFLKPENLQKTLITNTILTKRPINANGDLRYTPSNYSLKDIENLMVIISQDHNGLNAGSILFRNSPATALFLDIWTDPVVAECAKANNEQDMLGYLISKHSQLASLVGLIPQRKINAFHEGPENMEWQKGDLVIHFAGCWVENRCDELWQKFYALID
Protein: C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1) (Q9R007)
Organism: Mus musculus (Mouse)
Function: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19074552}; Single-pass type II membrane protein {ECO:0000269|PubMed:19074552}.
Interaction partners:
- TYRO protein tyrosine kinase-binding protein
- Hematopoietic cell signal transducer
- High affinity immunoglobulin epsilon receptor subunit gamma
- C-type lectin domain family 4 member A
- Tyrosine-protein kinase SYK
- Triggering receptor expressed on myeloid cells 1
Sequence:
MNWHMIISGLIVVVIKVVGMTFFLLYFPQVFGKSNDGFVPTESYGTTSVQNVSQIFGRNDESTMPTRSYGTVCPRNWDFHQGKCFFFSFSESPWKDSMDYCATQGSTLAIVNTPEKLKYLQDIAGIENYFIGLVRQPGEKKWRWINNSVFNGNVTNQDQNFDCVTIGLTKTYDAASCEVSYRWICEMNAK
Protein: Uncharacterized protein (Q38AJ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWLRSRKCGGSLGEIGDGGRQYGQSTSVRARSAPAERRSKSVGVSDVEKRLCIVKRNRMRHIYDGTEGNDEDVTQMSPPTPPLPPAIAPPCPAYPTFDLVRTPKHEQHLIEALVAELTDVIVFPSAVLGGK
Protein: Protein IQ-DOMAIN 3 (AtIQD3) (Q9FT53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Nucleus, nucleolus {ECO:0000269|PubMed:28115582}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:28115582}.
Interaction partners:
- Receptor protein kinase-like protein At4g34220
- Probable protein phosphatase 2C 64
- Leucine-rich repeat receptor-like protein kinase PXC2
- Probable inactive receptor kinase At5g16590
- Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM2
- Probable LRR receptor-like serine/threonine-protein kinase IRK
- Receptor-like protein kinase At5g59670
- Tryptophan aminotransferase-related protein 4
- Mitochondrial import inner membrane translocase subunit PAM16 like 1
- Tryptophan aminotransferase-related protein 3
Sequence:
MGKSWFSAVKKALSPEPKQKKEQKPHKSKKWFGKSKKLDVTNSGAAYSPRTVKDAKLKEIEEQQSRHAYSVAIATAAAAEAAVAAAQAAAEVVRLSALSRFPGKSMEEIAAIKIQTAFRGYMARRALRALRGLVRLKSLVQGKCVRRQATSTLQSMQTLARVQYQIRERRLRLSEDKQALTRQLQQKHNKDFDKTGENWNDSTLSREKVEANMLNKQVATMRREKALAYAFSHQNTWKNSTKMGSQTFMDPNNPHWGWSWLERWMAARPNENHSLTPDNAEKDSSARSVASRAMSEMIPRGKNLSPRGKTPNSRRGSSPRVRQVPSEDSNSIVSFQSEQPCNRRHSTCGSIPSTRDDESFTSSFSQSVPGYMAPTQAAKARARFSNLSPLSSEKTAKKRLSFSGSPKTVRRFSGPPKLESNVTKKDTNLA
Protein: Uncharacterized protein (Q586K3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRGGARTLQDEKVLVQELGRLFHVARANAREQRVIKRAAARTEEGSASPSKPRTGKASEKKPKKKESNSKKGKKGKSSSDKSRRTRGPRRKTRGGTVWVVLKGGFTRVPTTSMTAIVEHNKVFRGRLSEQRRLAALEAAEAYVQTAWQQAQEAGLLLPDGSGPNSDEGLEYLREQYDVAAGILRREPVGARLKQVVESTISSSAAVGAADMTTAVPETVYDRDQWADIITRENVILRRFSKSLPLETDNTEAVLAEAAEVPSKFYFQIAEPLAPQDSNTLALTPNSSSADLLHGEQVIDVLPTKCIVRIRGSGGKKHTTIISTPKGVNSFKSNFMQLIRKEISNSKLPRGEHTVESKQHHQRTGSGSGTSDNASRGQPKRHNNRRRK
Protein: Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP) (P23611)
Organism: Mus musculus (Mouse)
Function: Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. Positively regulates macroautophagy in dendritic cells (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:17579016}. Cytoplasm {ECO:0000250|UniProtKB:Q02556}. Note=In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction. {ECO:0000250|UniProtKB:Q02556}.
Interaction partners:
- Transcription factor PU.1
- Interferon regulatory factor 1
- Transcription factor Spi-B
- Basic leucine zipper transcriptional factor ATF-like 3
- Signal transducer and activator of transcription 1
- Interferon gamma
- Interferon regulatory factor 5
- Nuclear factor of activated T-cells, cytoplasmic 1
- E3 ubiquitin-protein ligase TRIM21
- Tumor necrosis factor
Sequence:
MCDRNGGRRLRQWLIEQIDSSMYPGLIWENDEKTMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKLGVAPAGCMSEVPEMECGRSEIEELIKEPSVDEYMGMTKRSPSPPEACRSQILPDWWVQQPSAGLPLVTGYAAYDTHHSAFSQMVISFYYGGKLVGQATTTCLEGCRLSLSQPGLPKLYGPDGLEPVCFPTADTIPSERQRQVTRKLFGHLERGVLLHSNRKGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTNQFIRELQQFYATQSRLPDSRVVLCFGEEFPDTVPLRSKLILVQVEQLYARQLVEEAGKSCGAGSLMPALEEPQPDQAFRMFPDICTSHQRPFFRENQQITV
Protein: HAPE (O59849)
Organism: Aspergillus oryzae (Yellow koji mold)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEQSTQSASQQQGRQQPVYDTRNGGHYGASAALSAQGYAPVAELYTGTWANVNQGLQGTARDILTTYWQHIINHLESDNHDYKIHQLPLARIKKVMKADPEVKMISAEAPILFAKGCDIFITELTMRAWIHAEDNKRRTLQRSDIAAALSKSDMFDFLIDIVPREEATSHAKRSSQAAGAPSGAPGPTGAAGQLPPSQHGVQHPSHHMAPPDYSLGQHGLQDQEYRQPAMYAGPVQSDPTAAYGQPQSQMFEGMYAAYPHLPPQQ
Protein: THO complex subunit 2 (Q57ZD1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKREKRQKGKGTQSKAEEKQPEERPLFEFWWTHRTLTVELKSALSNPYVEGVIQSCKDEVKARARVVVDTTTSPRAKRNAEGWKSTMTLAWHKKLVEARNQLLSAFTEAQGKCEKDKVEGSPEKQASVVAVSRRETIALHQKALHIVLDVIFLEWKTHFDAAGGGDETANRFSALVDCLLEGIAFTHVNHWICASSSGEDTLSQDDLLGALGHYLQNHLKITFVEQIQLLPKFVQRMWELFHVELLELEETMLRSCGTHAVSGAEGETGDAVKDFEVRSLVSNVTKVLRKLYVETSARKSTKDLNNNEGNGYVVVATSSMAGAMVQSLGRWLPVCGDFLHSMLTCFNALKSEGSAGGDSHGVSAHKCIDGDKDSKGTECPKTEGMLPAAEARGLLRGLQQEVQRVFVLLEQLDEFTPWPVLLADIASRTFHAARERVQPTDSEECRDNANITKGFREHTAMRAFLSWHSRAVATPLLSSSNAMVSRGTPLTLVEACSKALNGIISSALDKTSVPSDIHKRALRVLLVHRPLATLQHLIKSLCATGAEADRCDFEAIITDRGMSSASRSTAFSEATLDADDVAFMFFPKFFAVANFIESSLASLCEDVKSVLNSTAAGKDSCVADHTVNTSQFVERLFAAALEESIITSGTGSCSVAVSEWLMFLGFVASDSPLFEKTTIQHVRLAARRFFAPGLPMMSCLHRLIRQRHQYGLVAFFLPPLRAIGVDHSTAKDAEHVACALRYPRCAEVAYLEELPRGYYSRQPQRLALNAKNDALQFFHNILMTPGSVKKERDGDDKMSKSGGEKEKEADVVRRLFVEIVAHIGELVMARLRGVGEARLLGPTGAGCVVVDAMTAFFMGVMRLCNTVTYWDVSRRQQVQKAIVEKLLSRANVAREGPVLPRLALAVLLQGNVAYDEEVKPHIPHAWCDYLCSMELEDIDSRANVCAMNLLRLCNRNYMKSIPTKTLLACRAMLEQPTTKEKDISTQEKLDTGISASVKHDFDALRQRAANNAPADVQQQVGPVPTDSMVEEKKEVANTTTDTSSATLKVEEESTVSPTTGAQAEAPIAVTGSAINKGSEAPASGDDKLLNAVVKPYMDAVITVFVMRARTSVADAVLTGIAVKKWLISCAGNLESRALLNAVRRIVLQANAKVLHATKMECTALAAFLGVLVDEIVLPYRLNPCRAVPPHGDQQKQPPTTAEANVPARTEGTQNNWIHDVLPASGKDAAALLQTLIMDTTRNIARFLGENTSLGDWKAYTLTFHMRRVIGLVRRNKELFLDAVKKRQQTLGIILSTDSTHPVNLLASVECPLLERMTGPAVSAEQLFMVSPDPKTSVAARTETQGSAGVDGRTTGSSKRKRDRENDHEADSNHDHRHGRLRRRGGDRARDRDRSRERDNDRGAVRDYDRDREVSRGRERDRDANRDRDRHWEWDFDRDEQDDEHHGHNRRYRRWRKRDRGQ
Protein: mRNA decapping complex subunit 2 (EC 3.-.-.-) (O13828)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:23319050}. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay. {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:23319050}.
Interaction partners:
- mRNA-decapping enzyme subunit 1
- Enhancer of mRNA-decapping protein 3
- Uncharacterized protein C18G6.09c
- LSM1-LSM7 complex subunit lsm1
- Putative ATP-dependent RNA helicase ste13
- Deadenylation-dependent mRNA-decapping factor pdc2
- 5'-3' exoribonuclease 1
- Enhancer of mRNA-decapping protein 4-like protein pdc1
- LSM complex subunit lsm4
- ATP-dependent helicase upf1
Sequence:
MSFTNATFSQVLDDLSARFILNLPAEEQSSVERLCFQIEQAHWFYEDFIRAQNDQLPSLGLRVFSAKLFAHCPLLWKWSKVHEEAFDDFLRYKTRIPVRGAIMLDMSMQQCVLVKGWKASSGWGFPKGKIDKDESDVDCAIREVYEETGFDCSSRINPNEFIDMTIRGQNVRLYIIPGISLDTRFESRTRKEISKIEWHNLMDLPTFKKNKPQTMKNKFYMVIPFLAPLKKWIKKRNIANNTTKEKNISVDVDADASSQLLSLLKSSTAPSDLATPQPSTFPQPPVESHSSFDIKQKILHLLNEGNEPKSPIQLPPVSNLPLNPPIQSSNSRLSHDNNSFDPFAYLGLDPKNPSASFPRVVSQNNMLTNKPVLNNHFQQSMYSNLLKDQNSVQHLFAASDMPSPMELPSPSTVYHQVFYPPTSTSVSSYGLGKTPQPAYGSSSPYVNGHQTQQISSLPPFQSQTQFLARNSDNSGQSYNSEGDSNSKRLLSMLSQQDTTPSSSTLSKEANVQLANLFLTPNSLETKKFSDNSQGEEISDNLHGESCNNPNANSVHSAQLLQALLHPSATETKEETPKKTSDSLSLLTLLKSGLPTPANDLQNKSQNNERKASSQVKELEVKNYSKSTDLLKKTLRIPRNDEPLEAANQFDLLKVSPQQKSEVPPKRNELSQSKLKNRKKKENSETNKNHVDMSPGFVKILKRSPLADQKKEDTQESDFKGSDDHFLSYLQSVVSSNSNGLH
Protein: Hairy/enhancer-of-split related with YRPW motif-like protein (Hairy and enhancer of split-related protein 3) (Hairy-related transcription factor 3) (HRT-3) (mHRT3) (Q9DBX7)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Hairy/enhancer-of-split related with YRPW motif protein 1
- Hairy/enhancer-of-split related with YRPW motif protein 2
- Recombining binding protein suppressor of hairless
- Neurogenic locus notch homolog protein 1
- Mastermind-like protein 1
- Protein jagged-1
- Neurogenic locus notch homolog protein 3
Sequence:
MKRPRAPSGSDGESDGPIDVGQENDLSQMARPLTTPSPSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSHADPVRIRLLSHLKSYAAEMEPSPTTTSALAFPVWPWSFLHSCPGLPSLNSQLAILGRVPGPVLPSISSPPYPISALRSAPVHRPAGTIPPTRRNLLPSRGVTSTQRAHLPERPAAPPPTALDARAARSIVPIPPCSPTTAPGAGKSDDNVSGSISSPCPSGPTGRPAGAVFYHSWVSEITEIGAF
Protein: Cathepsin Z (EC 3.4.18.1) (L3 cysteine protease) (LOVCP) (Q6PN98)
Organism: Onchocerca volvulus
Function: Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (Probable). Required for the degradation and shedding of the old cuticle (Probable).
Subcellular location: Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:8939969}. Secreted {ECO:0000269|PubMed:8939969}. Note=Localizes in secretory vesicles in the hypodermis of L3 larvae. {ECO:0000269|PubMed:8939969}.
Interaction partners:
- Uncharacterized protein
- Carboxypeptidase
- Uncharacterized protein
- Uncharacterized protein.
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Uncharacterized protein
Sequence:
MLAILFNFFLLTYFTNITLGKVGKSIDLDTRNGYNVHGCYKQTGKIYAHKTYPRQYEAENYNFDDLPVAWDWRNINGVNYASVDRNQHIPQYCGSCWAFGSTSALADRFNIKRKGAWPPAYLSVQEVIDCANAGSCEGGEPGPVYKYAHEFGIPHETCNNYQARDGTCSSYNKCGSCWPGSCFSIKNYTIYRVKNYGAVSGLHKMKAEIYHHGPIACGIAATKAFETYAGGIYNERTNEDIDHIISAHGWGVDSESGVPYWIGRNSWGTPWGENGWFRIVTSEYKNSSSKYNLKIEEDCVWADPIA
Protein: Transcription factor E2F6 (E2F-6) (E2F-binding site-modulating activity protein) (EMA) (O54917)
Organism: Mus musculus (Mouse)
Function: Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (By similarity). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O75461}.
Interaction partners:
- Transcription factor Dp-1
- Polycomb group RING finger protein 6
- Transcription factor Dp-2
- Chromobox protein homolog 3
- Lethal
- E3 ubiquitin-protein ligase RING1
- E3 ubiquitin-protein ligase RING2
- RING1 and YY1-binding protein
- YY1-associated factor 2
- MAX gene-associated protein
Sequence:
MSQQRTARRQPSLLVDPAQETVRRRCRDPINVENLLPSKIRINLEENVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIELVEKKSKNHIRWIGSDLNNFGAAPQQKKLQAELSDLSAMEDALDELIKDCAQQLLELTDDKENERLAYVTYQDIHGIQAFHEQIVIAVKAPEETRLDVPAPREDSITVHIRSTKGPIDVYLCEVEQNHSNGKTNDGIGASPSKSSHPQCPEKEDEPPQ
Protein: Homeobox protein ceh-43 (Q18273)
Organism: Caenorhabditis elegans
Function: Probable transcription factor. Binds to the sequence motif 5'-ATAAT-3' in regulatory elements. Required for development of the anterior hypodermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability. Modulates and maintains dopaminergic neuron differentiation. May activate dopamine pathway genes in concert with ETS domain-containing protein ast-1, and homeobox proteins ceh-40 and ceh-20.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Homeobox protein ceh-32
- Transcription factor ast-1
- Homeobox protein ceh-20
- Homeobox protein ceh-40
- Paired domain-containing protein
- Transcription factor unc-86
- Homeobox protein unc-62
Sequence:
MDPSKGFEYVAGDYYQTSGVAPPTSNGAGSNVSPYFPYHAYPTSSTNGATGGSMYGTPQQTSAYAMYPPGPGSSPEEAFPEHTTTKIVEGCEAKYNVKGKKMRKPRTIYNSSQLQMLQKKFQKTQYLALPDRAALAHELGLSQTQVKIWFQNRRSKQKKQKGGSSDHASDEEDDDTEESKPESPPMGESVMIQESSEPRTLVSSSIKTEMKEEYPPMTLNEQYASPYLYGSDFSTILPPSQGFPNNALYNTAGAYPSIDYTNGVYQNTLYKYV
Protein: Acyl-CoA synthetase X1 R (EC 6.2.1.3) (RE32325p) (Q9VDU3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
Sequence:
MPYTPENSYDNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLASYMRSLGLLQSDIVGLIGRNTTHMLAVAYACFFNGIAFHSLNITYDRDTIEKIYKVTRPSIIFCDGDEFEKVRSATAELDVKIVTMRNHPLDSIKIDEVVATPIEENFQPAKLEKGNDQTLAILCSSGTTGTPKAVTITNSRHILAGNYHLTTADVQYSHNTLDWITGLLTTITSGVFSTTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALMINCPDFETCDLSSLRCYMFGGSRAALEVQKGIRSRLSHNCLQFVYGFTELGAMATINCHFDEKTGSVGQLVNGLKMKIKNDDGESLGPDEIGEVCIMNNQHWSGYYGNEVETRNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIMYYPNDIESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSRTDSKYKQLNGGAVIVDDLQRSANGKTNRMANKAHFLHLKNRKNILLSQINT
Protein: Myosin heavy chain kinase A (MHCK-A) (EC 2.7.11.7) (P42527)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes its autophosphorylation, which is needed for enzymatic activity and phosphorylates myosin II heavy chain at a threonine in the C-terminal tail region. This phosphorylation is critical for regulating the assembly and disassembly of myosin II filament, affecting myosin localization during an array of cellular contractile events, including cytokinesis and capping of cell surface receptors as well as chemotactic cell locomotion.
Interaction partners:
- Myosin-2 heavy chain
Sequence:
MFNIKKRKESITGIPPINVNSPQSVPLSGTLQSPLITPNSPNFVSRQCPFKKFGCSSFLVSKAEFDNHLKDDAQFHLQLAVEKFDHQFDLHTQLMAHFTEQMEDQLEKTMKVVRNHTDSLGGNVQTKLDEGIEKCMAFAKKVEQQQQQLAKRLITQQIQEKKSTSSPLVKGGISGGGGSGGDDSFDGANISSMSTSKQELQQELQSLSIKMKKELTELSDELSQKLERSTGNIDIKIKRIEGEVNEKIDKRQLVSTIDDSIGKKTDSIGYTLESSIIKKVEEKEKKKSEQNQLLFDSKIESLKDKIKIIETQQLDTSSEVRKLKLESTSSGNLMAGLNGTSGRPSSSSHFIPSSVSAAANNINKNEIMEEVKKVEEKLQKKIREEIDNTKSELSKVERSVKDNRSEIEGLEKDCKNQFDKQDNKIKQVEDDLKKSDSLLLLMQNNLKKYNEFVDRERDRESERLKLQDSIKRLEQNQKKIEAEIQEGNEQVERVLREEASISPISSVPKSPITTKRSSIILNSPPMTSQQSSPKIQDLLSSSGSSSVSGINISSETGEMGILWEFDPIINKWIRLSMKLKVERKPFAEGALREAYHTVSLGVGTDENYPLGTTTKLFPPIEMISPISKNNEAMTQLKNGTKFVLKLYKKEAEQQASRELYFEDVKMQMVCRDWGNKFNQKKPPKKIEFLMSWVVELIDRSPSSNGQPILCSIEPLLVGEFKKNNSNYGAVLTNRSTPQAFSHFTYELSNKQMIVVDIQGVDDLYTDPQIHTPDGKGFGLGNLGKAGINKFITTHKCNAVCALLDLDVKLGGVLSGNNKKQLQQGTMVMPDILPELMPSDNTIKVGAKQLPKAEFSKKDLKCVSTIQSFRERVNSIAFFDNQKLLCAGYGDGTYRVFDVNDNWKCLYTVNGHRKSIESIACNSNYIFTSSPDNTIKVHIIRSGNTKCIETLVGHTGEVNCVVANEKYLFSCSYDKTIKVWDLSTFKEIKSFEGVHTKYIKTLALSGRYLFSGGNDQIIYVWDTETLSMLFNMQGHEDWVLSLHCTASYLFSTSKDNVIKIWDLSNFSCIDTLKGHWNSVSSCVVKDRYLYSGSEDNSIKVWDLDTLECVYTIPKSHSLGVKCLMVFNNQIISAAFDGSIKVWEWQSK
Protein: Col6a3 protein (Q66K11)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
APARPAPAQPVLAKPDPAKPAQARPAPAKPASAKLVPPQPVHVQPAPAQTASVRPAPAKPAPPQPAAAKPVPAKPAVPAQPAPPQPAAAKPVPAKPAVPAQPAAAQPMPAQPVLTKSAAVKPASANKPVAAKPVATNTATATARPALAAKPAAAKPAATRPLAAAVRPVATKPEAPRQQAKPAATKPATTKPLARVSREVQVSEVTENSARLHWERPEPSSSFFYDLTVTSAHDQSLVLRQNLTVTDRVIGGLLAGQLYHVVVVSYLQSQVRAIYQGSFNTKKTQPPPLQAAHRASSSTINLMVNTEPLFLTKTDICKLSRHAGTCVDFKLLWHYDLESKSCKRFWYGGCGGNENRFHSQEECEKMCSPELTV