wanglab/gogpt-training-data huggingface dataset:
Protein: PI-PLC X domain-containing protein At5g67130 (Q93XX5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Phosphoinositide phospholipase C 1
- Glycerophosphocholine acyltransferase 1
- Large ribosomal subunit protein uL23m
Sequence:
MSACINGLCRAVTVSLLLLLLSFSFSSACSNGNCQLLDSCSSATDCVSGLYCGDCPAVGRSKPVCTRGQATSPTSIINGLPFNKYTWLMTHNAFSNANAPLLPGVERITFYNQEDTITNQLQNGVRGLMLDMYDFNNDIWLCHSLRGQCFNFTAFQPAINILREVEAFLSQNPTEIVTIIIEDYVHRPKGLSTLFANAGLDKYWFPVSKMPRKGEDWPTVTDMVQENHRLLVFTSVAAKEDEEGVAYQWRYMVENESGDPGVKRGSCPNRKESQPLNSKSSSLFLMNYFPTYPVEKDACKEHSAPLAEMVGTCLKSGGNRMPNFLAVNFYMRSDGGGVFEILDRMNGPVLCGCETLSACQPGAAYGSCKNVTVQTRTPSMDSTAGSNSGGSYSGSVQFSRSLASVAQLNNIVVFCFSLLPLLIFLL
Protein: GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (A0A1W2PRH3)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU367138}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367138}.
Interaction partners:
Sequence:
MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFNCAGS
Protein: Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) (P00156)
Organism: Homo sapiens (Human)
Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00157}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00157}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 2
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 4L
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- ATP synthase F
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 3
- Cytochrome b-c1 complex subunit 9
Sequence:
MTPMRKTNPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA
Protein: phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (Q98T97)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MSCLLLGLIRRRGGVGTSVGVRSLASIPSLPPAVADFVKRAVDECKPANVHVVTGSAEESAHILAGLEKDGMVKRLPKYENCWLARTDPKDVARVESKTVIVTKNQRDTIPIPDGGAKSQLGSWMSEGDFQKARQDRFPGCMSGRTMYVIPFSMGPVGSPLSKFGVQVTDSPYVVASMGIMTRMGTPVMDKLAQGAEFVRCQHSLGRPLPLKAPLVNSWPCNPEKVLISHLPDTRQILSFGSGYGGNSLLGKKCFALRIASRIAKDEGWLAEHMLILGITNPQGVKRYVAAAFPSACGKTNLAMMKPALPGWTVECVGDDIAWMKFDSQGKLRAINPENGFFGVAPGTSLKTNPHAMATIAKNTVFTNVGETSDGGVWWEGLDPPAAGVSLTDWHGKSWKAGDSGPCAHPNSRFCTPAAQCPIIDPQWESDEGVPIDAIIFGGRRPEGVPLVYESFNWRHGVFVGASMRSEATAAAEYKGKVIMHDPFAMRPFFGYNFGDYLAHWLSMETRKGATHLPKIFHVNWFRKDPTSGSFLWPGFGDNARVLEWIFKRCSREREDEAAKKSMVGWVPLEGAINLQGLGSKVDMGALFDLPKAFWEKETQELRAYFTQQVGADLPQQVEGELKALEDRIRN
Protein: PMS1 homolog 2, mismatch repair system component (D4A360)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEPTEGASTECAKAIKPIDGKSVHQICSGQVVLSLSTAVKELIENSVDAGATSIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIREFADLTQVETFGFRGEALSSLCALSDVTISTCHVSASIGTRLVLDHNGKIIQKTPCPRPKGTTVSVQNLFYTLPVRHKEFQRNIKKEYAKMVQVLQAYCIISAGIRVSCTNQLGQGKRQPVVCTSGSSGMKENIGSVFGQKQLQSLVPFVQLPPSDSVCEEYCLSACGTPQSPFRISGFISQCTHGAGRSSTDRQFFFINQRPCDPAKVSRLVNEVYHMYNRHQYPFVVLNVSVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLMGMFDSDANKLSVNQQPLLNVEGNLVKLHTAEVGEQENSPSLRITAEEKRVASVSRLREAYSLHRTTETKSWGPETPELKQSFPSQKRGVSSSCPSDIISYRGLCGSQDKLVSPTDSPGDCMDREKGEKDSGLSSTSAGSEEGFSTPEVASSFSSDCNVSSPEDRPSQENTNCGEQFLEVDDHLSGTGHHLKPEDNGYKCRASLPPTRLSPSNAKRFRTEDRPSNVGVPQNTSAAEVDVAVKINKKIVLLDFSLSSLAKQMKQLQHLKQQSKSEHNYRKFRAKICPGENQAAEDELRREIRKSMFAEMEILGQFNLGFIVTKLKEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITWVHPSFRARSAPLQMKQLVPAAVCRHAYMWACIDTCTTHVHTFHIMIITAPLIESLLHGELLRECIHLIQVITPGSSCCHCCSQ
Protein: At5g22540 (Emb|CAB72473.1) (Transmembrane protein, putative (DUF247)) (Q9FK85)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pentatricopeptide repeat-containing protein At4g33170
- Serine/threonine-protein kinase ZRK1
- Fatty acyl-CoA reductase 1
- Disease resistance protein RRS1
- Arabidiol synthase
- Potassium channel GORK channel)
Sequence:
MDPQIVVDIKSLISEDNGLKLLRESAGSELCCIVRIPQSLARINLKAYEPKIVSIGPYHHGKEHLKMTQQHKRRFLKFFVAKMEEKGFVPQELVKAVSSLEGVIRGSYSEDLGLDSENLVQMMVLDGCFILTLFFVVSGKVEYTNLDDPIFRMPWILPSIRADLLLLENQVPYVLLQTLFETSKLVTCSGLNEIAFEFFNYSLQKPETFWEKHYGLEAKHLLDLIRKTFVPVPSQRRIKDHSSKSSFNDHEYLGFVLSAKKLHLRGIKFKPRKNTDSILDISYSNGVLHIPPVVMDDFTASIFLNCVAFEQLYADSSNHITSYVAFMACLINEESDASFLSERRILENYFGTEDEVSRFYKRIGKDIALDLEKSYLAKVFEGVNEYTSQGFHVHCAEFIHTHFDSPWTFASSFAALLLLLFAALQVFFAAYSYFRPPKEK
Protein: Transmembrane protein 176A (Hepatocellular carcinoma-associated antigen 112) (Q96HP8)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Transmembrane protein 176B
Sequence:
MGTADSDEMAPEAPQHTHIDVHIHQESALAKLLLTCCSALRPRATQARGSSRLLVASWVMQIVLGILSAVLGGFFYIRDYTLLVTSGAAIWTGAVAVLAGAAAFIYEKRGGTYWALLRTLLTLAAFSTAIAALKLWNEDFRYGYSYYNSACRISSSSDWNTPAPTQSPEEVRRLHLCTSFMDMLKALFRTLQAMLLGVWILLLLASLTPLWLYCWRMFPTKGKRDQKEMLEVSGI
Protein: Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) (Q9NRG0)
Organism: Homo sapiens (Human)
Function: Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA polymerase epsilon subunit 3
- Bromodomain adjacent to zinc finger domain protein 1A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1
- DNA polymerase epsilon subunit 2
- DNA polymerase epsilon catalytic subunit A
- Nuclear transcription factor Y subunit beta
- DNA polymerase epsilon subunit 4
- DNA polymerase alpha subunit B
- DNA-directed RNA polymerase III subunit RPC9
Sequence:
MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVLTAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYLKMLKEEKREEDEENDNDNESDHDEADS
Protein: Gap junction alpha-1 protein (Connexin-43) (Cx43) (P16863)
Organism: Xenopus laevis (African clawed frog)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P17302}; Multi-pass membrane protein {ECO:0000255}. Cell junction, gap junction {ECO:0000250|UniProtKB:P17302}. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and proper localization at ICD is dependent on TMEM65. {ECO:0000250|UniProtKB:P23242}.
Interaction partners:
Sequence:
MGDWSALGRLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFVCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSTPTLLYLAHVFYLMRKEEKLNRKEEELKMVQNEGGNVDMHLKQIEIKKFKYGLEEHGKVKMRGGLLRTYIISILFKSVFEVGFIIIQWYMYGFSLSAIYTCKRDPCPHQVDCFLSRPTEKTIFIWFMLIVSIVSLALNIIELFYVTYKSIKDGIKGKKDPFSATNDAVISGKECGSPKYAYFNGCSSPTAPMSPPGYKLVTGERNPSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNTHAQPFDFSDEHQNTKKMAPGHEMQPLTILDQRPSSRASSHASSRPRPDDLEI
Protein: 2-oxoglutarate dehydrogenase E1/E2 component (ODH E1/E2 component) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)] (Q8NRC3)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Function: Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF.
Interaction partners:
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes
- Oxoglutarate dehydrogenase inhibitor
- Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes
- Dihydrolipoyl dehydrogenase
- Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes
- Succinate--CoA ligase subunit alpha
- FHA domain-containing protein
- FHA-domain-containing proteins
- Succinate--CoA ligase subunit beta
Sequence:
MSSASTFGQNAWLVDEMFQQFQKDPKSVDKEWRELFEAQGGPNTTPATTEAQPSAPKESAKPAPKAAPAAKAAPRVETKPADKTAPKAKESSVPQQPKLPEPGQTPIRGIFKSIAKNMDISLEIPTATSVRDMPARLMFENRAMVNDQLKRTRGGKISFTHIIGYAMVKAVMAHPDMNNSYDVIDGKPTLIVPEHINLGLAIDLPQKDGSRALVVAAIKETEKMNFSEFLAAYEDIVARSRKGKLTMDDYQGVTVSLTNPGGIGTRHSVPRLTKGQGTIIGVGSMDYPAEFQGASEDRLAELGVGKLVTITSTYDHRVIQGAVSGEFLRTMSRLLTDDSFWDEIFDAMNVPYTPMRWAQDVPNTGVDKNTRVMQLIEAYRSRGHLIADTNPLSWVQPGMPVPDHRDLDIETHNLTIWDLDRTFNVGGFGGKETMTLREVLSRLRAAYTLKVGSEYTHILDRDERTWLQDRLEAGMPKPTQAEQKYILQKLNAAEAFENFLQTKYVGQKRFSLEGAEALIPLMDSAIDTAAGQGLDEVVIGMPHRGRLNVLFNIVGKPLASIFNEFEGQMEQGQIGGSGDVKYHLGSEGQHLQMFGDGEIKVSLTANPSHLEAVNPVMEGIVRAKQDYLDKGVDGKTVVPLLLHGDAAFAGLGIVPETINLAKLRGYDVGGTIHIVVNNQIGFTTTPDSSRSMHYATDYAKAFGCPVFHVNGDDPEAVVWVGQLATEYRRRFGKDVFIDLVCYRLRGHNEADDPSMTQPKMYELITGRETVRAQYTEDLLGRGDLSNEDAEAVVRDFHDQMESVFNEVKEGGKKQAEAQTGITGSQKLPHGLETNISREELLELGQAFANTPEGFNYHPRVAPVAKKRVSSVTEGGIDWAWGELLAFGSLANSGRLVRLAGEDSRRGTFTQRHAVAIDPATAEEFNPLHELAQSKGNNGKFLVYNSALTEYAGMGFEYGYSVGNEDSIVAWEAQFGDFANGAQTIIDEYVSSGEAKWGQTSKLILLLPHGYEGQGPDHSSARIERFLQLCAEGSMTVAQPSTPANHFHLLRRHALSDLKRPLVIFTPKSMLRNKAAASAPEDFTEVTKFQSVINDPNVADAAKVKKVMLVSGKLYYELAKRKEKDGRDDIAIVRIEMLHPIPFNRISEALAGYPNAEEVLFVQDEPANQGPWPFYQEHLPELIPNMPKMRRVSRRAQSSTATGVAKVHQLEEKQLIDEAFEA
Protein: SUN domain-containing protein 5 (AtSUN5) (F4JPE9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Encodes a member of the mid-SUN subfamily of SUN-domain proteins. It is involved in early seed development and nuclear morphology. [TAIR].
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- SUN domain-containing protein 2
- SUN domain-containing protein 1
- Protein KAKU4
- TIR domain-containing protein
- Nuclear envelope-associated protein 1
- Protein CROWDED NUCLEI 1
- WPP domain-interacting tail-anchored protein 2
- Nuclear envelope-associated protein 3
- Protein CROWDED NUCLEI 4
- bZIP transcription factor 18
Sequence:
MARRGSCSTICLNEKLQRFRIVRISDKADNFNSRSGSFFERSISLVLLLWCFLFLVYSKLGQSHDDYGNADRIGNYTDGSVSKTLNSTSSVFPQATEKENNFCLLRKGQLQDVYEHVLVNNALLICKVVLPERRISKKTLEARDPRYVNLEDKSLKVNGSSQLVNNGTRYRLEPDGNGYNYASAMKGAKVVDHNKEAKGASNVLGKDHDKYLRNPCSVSDKYVVIELAEETLVDTVRIANFEHYSSNPKEFSLSGSLSFPSDMWTPAGSFAAANVKQIQSFRLPEPKWLRYLKLNLVSHYGSEFYCTLSVVEVFGIDALEQMLEDLFVPSETPPSKPAMVELKTADEKQDGEIKSNRTDQIGKETEAQKKKDDVVKTINIIGDKKYEVKEKHNVLKVMMQKVKLIEMNLSLLEDSVKKMNDKQPEVSLEMKKTLVLVEKSKADIREITEWKGKMEKELRDLELWKTLVASRVESLARGNSALRLDVEKIVKEQANLESKELGVLLISLFFVVLATIRLVSTRLWAFLGMSITDKARSLWPDSGWVMILLSSSIMIFIHLLS
Protein: Calcium-dependent protein kinase 34 (EC 2.7.11.1) (Q3E9C0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger.
Subcellular location: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Probable aquaporin NIP4-2
- Putative aquaporin NIP4-1
- Cyclic nucleotide-gated ion channel 18
- Rop guanine nucleotide exchange factor 2
Sequence:
MGNCCSHGRDSDDNKEEPRPENGGGGVGAAEASVRASKHPPASPPPATKQGPIGPVLGRPMEDVKSSYTLGKELGRGQFGVTHLCTQKATGLQFACKTIAKRKLVNKEDIEDVRREVQIMHHLTGQPNIVELKGAYEDKHSVHLVMELCAGGELFDRIIAKGHYSERAAASLLRTIVQIIHTCHSMGVIHRDLKPENFLLLSKDENSPLKATDFGLSVFYKPGEVFKDIVGSAYYIAPEVLRRKYGPEADIWSIGVMLYILLCGVPPFWAESENGIFNAILSGQVDFSSDPWPVISPQAKDLVRKMLNSDPKQRLTAAQVLNHPWIKEDGEAPDVPLDNAVMSRLKQFKAMNNFKKVALRVIAGCLSEEEIMGLKEMFKGMDTDNSGTITLEELRQGLAKQGTRLSEYEVQQLMEAADADGNGTIDYGEFIAATMHINRLDREEHLYSAFQHFDKDNSGYITTEELEQALREFGMNDGRDIKEIISEVDGDNDGRINYEEFVAMMRKGNPDPNPKKRRELSFK
Protein: Insulin-like growth factor 2 preproprotein (Q2F6J8)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MGITAGKSVLVLLAFLAFASCCYAAYRPSETLCGGELVDTLQFVCGDRGF
Protein: Tex271 protein (Q62305)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MKEREEMWQKIEELARLNPQYPMFRLLRHCPCVLHGDRDAHSRGHSAPEEDGGDRGRADAEGHQEGQSAAPEEVRAATGRVHHQGTRGHKRAEEFLTASRRPSDPLTFPSHRIPAHSAWREPIPSSTNRPLDPALCRRGW
Protein: Probable maleylacetoacetate isomerase 2 (MAAI 2) (EC 5.2.1.2) (Glutathione S-transferase zeta 2) (EC 2.5.1.18) (Q9VHD2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Has no glutathione thioltransferase activity with 4-hydroxynonenal (4-HNE), adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Fumarylacetoacetase
- Homogentisate 1,2-dioxygenase
- Probable maleylacetoacetate isomerase 1
- glutathione transferase
- Glutathione S transferase D10, isoform A
- 4-hydroxyphenylpyruvate dioxygenase
- Glutathione S transferase O2, isoform A
- Glutathione S-transferase S1
Sequence:
MSTNLCPNASSSDIQPILYSYWRSSCSWRVRIAMNLKEIPYDIKPISLIKSGGEQHCNEYREVNPMEQVPALQIDGHTLIESVAIMHYLEETRPQRPLLPQDVHKRAKVREIVEIICSGIQPLQNLIVLIHVGEEKKKEWAQHWITRGFRAVEKALSTSAGKYCVGDEISMADCCLVPQVFNARRFHVDLRPYPIILRIDRELESNPAFRAAHPSNQPDCPPELPNK
Protein: Probable H/ACA ribonucleoprotein complex subunit 4 (EC 5.4.99.-) (Q54T81)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit 3
- Nucleolar protein 58
- Nucleolar protein 56
- Probable H/ACA ribonucleoprotein complex subunit 1
- H/ACA ribonucleoprotein complex subunit 2
- CS domain-containing protein
- rRNA 2'-O-methyltransferase fibrillarin
- NHP2-like protein 1 homolog
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- tRNA pseudouridylate synthase
Sequence:
MTTDKKSKSKSSEKSTQEVEQVIKPEKTPILDTSKWPLLLKNYDQLSVRTGHYTPIPNGHSPLKRPIKEYVKYGIINLDKPSNPSSHEVVAWIRTILRVTKTGHSGTLDPKVTGCLIVCIERATRLVKSQQGAGKEYIGIVRLHGAIEGTTELSKAVDTLTGALFQRPPQKSAVKKRLRVRTIHNSKLLEFDPERNLGLIWVDCEAGTYIRTLCVHIGLLMGVGGHMQELRRVRSGIMSEKKGQVTMHDVKDAQYEYDNSKDESYLRRVIQPLEAILTNYKRIVVKDSAINAICYGAKLMIPGLLRYEQDIESNEEVVLITTKGEAIAIGIAQMTTASMATCDHGVVATIKRVIMDRDVYPVRWGLGPKAKVKKEMIKDGKLDKFGKPNEKTPSDWTNTYTYYTGQVATTTTTSPVESMNVDTPKKATASVAVKAEVESSEDEKPVPKKEKKDKKEKKKDSSDDESEEEKSSKKDKKEKKEKKEKKEKKSSKDDSDDESSKKEKKDKKRKKSSDKDSDSEKESSDKKDKKDKKEKKKSKN
Protein: Proline-rich protein HUA1 (P40325)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in assembly and disassembly of the actin cytoskeleton.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11914276}.
Interaction partners:
- Reduced viability upon starvation protein 167
- Actin cytoskeleton-regulatory complex protein SLA1
- Protein YSC84
- UBA domain-containing protein RUP1
- Uncharacterized protein YGR269W
Sequence:
MSKDTHDDELPSYEDVIKEEERLQSQPPRPPRPAANLAQGHQSRPHQRPSTMPATSSSQTYAHSHSYTPTSSQPRPPPRPQQNPSLPWTYPPRFYCSKCGNTGYKLKNGRSCKSCWRRFAPQNNVVSAPTYYTNYTMPVYTNAWQGNRPLYVQPGDPRLGGVLCGECRGSGRTRFLLDEDICPLCHGVGRIITQPQRY
Protein: Protein S100-A15A (Protein S100-A7A) (S100 calcium-binding protein A15A) (S100 calcium-binding protein A7A) (Q6S5I3)
Organism: Mus musculus (Mouse)
Interaction partners:
- Keratin, type I cytoskeletal 16
Sequence:
MPDTPVEDSLFQIIHCFHHYAAREGDKETLSLEELKALLLDSVPRFMDTLGRRQPYYITELFRAADKNKDNQICFDEFLYILGKLVKDYHLQFHRQLCAHYCTEHSLY
Protein: Ubiquitin-like protein 4A (Q5HY81)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
Sequence:
MQLTVKALQGRECSLQVPEDELVSTLKQLVSEKLNVPVRQQRLLFKGKALADGKRLSDYSIGPNSKLNLVVKPLEKVLLEEGEAQRLADSPPPQVWQLISKVLARHFSAADASRVLEQLQRDYERSLSRLTLDDIERWAHHHHSWHVPGSGQVLGTPHSLTWVCFHTLRRGEPAQQRHRR
Protein: Neuroligin-2 (Q8NFZ4)
Organism: Homo sapiens (Human)
Function: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity). {ECO:0000250}.
Interaction partners:
- Neurexin-2
- Neurexin-1
- Disks large homolog 4
- MAM domain-containing glycosylphosphatidylinositol anchor protein 1
- Neurexin-3
- Gephyrin
- Rho guanine nucleotide exchange factor 9
- SH3 and multiple ankyrin repeat domains protein 3
- LHFPL tetraspan subfamily member 4 protein
- LHFPL tetraspan subfamily member 3 protein
Sequence:
MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV
Protein: Transcription factor ste11 (P36631)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'-TTCTTTGTTY-3'.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:12697825}. Cytoplasm {ECO:0000269|PubMed:12697825}. Note=Accumulates in the nucleus under conditions of nitrogen starvation and in the presence of mating pheromones.
Interaction partners:
- Meiosis protein mei2
- Serine/threonine-protein kinase tor2
- Mitogen-activated protein kinase spk1
- Negative regulator of sexual conjugation and meiosis
- Protein kinase byr2
- Protein ste7
- Sexual differentiation protein ste4
- Mitogen-activated protein kinase sty1
- Zinc finger protein rst2
- Guanine nucleotide-binding protein alpha-1 subunit
Sequence:
MSASLTAEQKDQKSSVKRPLNSFMLYRRDRQAEIPTSNHQSISRIIGQLWRNESAQVKKYYSDLSALERQKHMLENPEYKYTPKKRSTVRRRHKKVSPSSGSFVASDYVVLQQIAQSSKTLKQTEPEKPVNEEETLAALLAPALSYPKSGKSNLIETSELSCLSSSPMIRSHTIPSLSFTDQVSTTISTLDKSEQAPSSLGIYYRSPSSGSPIGRTKSVCLANKARIVPKRSMSSDGCVDKSYQMSKTPSLEANLPQNSSNCSARRVPKFDSKGTVSEQSNSDSPELSADKVLSHCSPIDARPSTPSCPNASISPKTPNTGDHYGFDGAEYLGTPLSVGSTTAYLYGQETELLSTPYCHTSYPAMSRLNSSSGYTCVSSSSVTNSGHTENNTWRSDEQSKGFVDINSFSQSLFSNGNYEFAAHSQELDDLFSQITDFTSTDPIASSLKDANSLGPSLLEPWLPNSNLF
Protein: Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) (Q9Z2U1)
Organism: Mus musculus (Mouse)
Function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P28066}. Nucleus {ECO:0000250|UniProtKB:P28066}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P28066}.
Interaction partners:
- 26S proteasome regulatory subunit 4
- Proteasome subunit alpha type-1
- 26S proteasome non-ATPase regulatory subunit 2
- Proteasome subunit beta type-2
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 11
- Proteasome subunit alpha type-3
- 26S proteasome non-ATPase regulatory subunit 6
- Proteasome subunit beta type-3
- Proteasome subunit beta type-5
Sequence:
MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI