wanglab/gogpt-training-data huggingface dataset:
Protein: Meiotically up-regulated gene 33 protein (O74472)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Note=Localizes to the barrier septum and the cell tip.
Interaction partners:
- SUR7 family protein pun1
- Cytoskeletal signaling protein slm1
- Non-classical export protein 2 homolog
- Probable sphingolipid long chain base-responsive protein pil1
Sequence:
MRIRSATPSLILLVIAIVFFVLAICTPPLANNLTLGKYGDVRFGVFGYCLNSNCSKPLVGYNSDYLDEHAKDGFRTSVIVRQRASYGLVIVPVSACICLISTIMTIFAHIGAIARSPGFFNVIGTITFFNIFITAIAFVICVITFVPHIQWPSWLVLANVGIQLIVLLLLLVARRQATRLQAKHLRRATSGSLGYNPYSLQNSSNIFSTSSRKGDLPKFSDYSAEKPMYDTISEDDGLKRGGSVSKLKPTFSNDSRSLSSYAPTVREPVPVPKSNSGFRFPFMRNKPAEQAPENPFRDPENPFKDPASAPAPNPWSINDVQANNDKKPSRFSWGRS
Protein: Fibronectin (F1SS24)
Organism: Sus scrofa (Pig)
Interaction partners:
- Integrin alpha-5
- Integrin beta
- Integrin beta-1
- Integrin alpha-V
- Integrin beta
- Integrin alpha-8
- Integrin beta
- Integrin subunit alpha 3
- Syndecan-4
- Integrin beta-6
Sequence:
LLGGVGPGLLLLAVLSLGTTVPSTGASKSKRQAQQIVQPQSPLVDSQRKPGCYDNGKHYQINQQWERTYLGSALVCTCYGGSRGFNCESKPEPEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSLQTTSAGSGSFTDVRTAIYQPQPHPQPAPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCVAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETRTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPGTTGPVQVIITETPSQPNSHPIQWNAPEPSHISKYILRWKPKNSPNRWKEATIPGHLNSYTIKGLRPGVVYEGQLISVQHYGHREVTRFDFTTTSTSSAVTSNTVVGETTPFSPVVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETTGVPRPDKVPPPKDLQFVEVTDVKVTIMWTPPESPVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYHFKVFAVNQGRESKPLTAQQTTKLDAPTNLQFINETDSTVMVTWTPPRARIAGYRLTVGLTRGGQPKQYNVGPSASQYLLRNLQPGSEYAVTLVAVKGNQQSPRATGVFTTLQPVGSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTISVLRDGQERDTPIVKKVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGYSLEEVVHADQSSCTFENLSPGLEYNVSVYTVKNDKESVPISDTIIPEVPQLTDLSFVDITDSSIGLRWTPINSSTIIGYRITVVAAGEGIPIFEDFADSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNVGPDTIRVTWAPPPSIELTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGIDFSDITANSFTVYWIAPRATITGYKIRHHPEHMGGRPREDRVEYVVSIVAVNGREESPPLVGQQSTVSDVPRDLQVIATTPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPVSIDYRTEIDKPSQMQVTDVQDNSISVRWLPSSSHVTGYRVTTTPKNGSGPSKTKTVGPDQTEMTIEGLQPTVEYVVSVYAQNQNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTNLKFTQVTPTSLTAQWTAPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSIYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRAKITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPATEYTIQVIALKNNQKSEPLIGRKRTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTKPGYDTGNGIQLPGTSGQQPSLGQQMIFEEHGFRRTTPPTTATPVRHRPGPYTPNVNEEIQVGHVPRGDVDHHLYPHVLGLNPNASTGQEALSQTTISWTPFQESSEYIISCHPVGIDEEPLQFRVPGTSASATLTGLTRGATYNIIVEALKDQKRHKIREEVVTVGNSVDQGLSQPTDDSCFDPYTVSHYAIGEEWERLSESGFKLSCQCLGFGSGHFRCDSSKWCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGAELGPEGSTGHSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADIEDSRE
Protein: Uncharacterized protein AT4g03420 (Uncharacterized protein F9H3.4) (Q9ZT70)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVFGKGSNLDRFLHCTTPVVPPQSLSKAEIRSLNRIWHPWERQKVEFFRLSDLWDCYDEWSAYGAGVPIRLSNGESLVQYYVPYLSAIQIFTSRSSLIRLRDDSEDGESRDSFSDSYSDESESDKLSRCASDEGLEHDALLHPNDRLGYLYLQYFERSAPYARVPLMDKINELAQRYPGLMSLRSVDLSPASWMAVAWYPIYHIPMGRTIKDLSTCFLTYHTLSSSFQDMEPEENGGEKERIRKEGEGVTLLPFGLATYKMQGNVWLSEDDQGQDQERVLSLLSVADSWLKQLRVQHHDFNYFSRMAHLARRLLFSLVAIYRVCPVVGVAVAAVKRTERFLNTQVQRFQRFGCRIALK
Protein: Arginine-glutamic acid dipeptide repeat protein (Q8RX35)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVLLMDGENNLMEETTAVIEEDSYDDEFPCGDPQVEPRVGDEFQVDIPLMMSASKRAVFLSNPVALDDSTCSFLVGLPVQVMWIDKVGIGQGNGDGNVDMNQSLKSLRAKKGRCSAKIRGKSDKNSETKKQRLNLEAVPAIPSSSWDDLEVASFVLGLYTFGKNFTQMNNFMENKGIGEIMLFYYGKFYNSAKYHTWSESRKKRNRKCVYGRKLYSGWRQQQLLTRLMPSIPDEPQKQMLVDVSKSFAEGTITLEKYVSAVKNLVGLRLLVDAVAIGKEKEDLTVPTSTPMKTKPWFTVSSKSSLVPGEGDYNSLTSAGIINQLTGCSRLSKARCNDIFWGAVWPRLLARGWRSQQPEDRGYFKSKDYIVFIVPGVKKFSRQELVKGDHYFDSVSDILTKVVSEPELLENETGGVAAENPSDQSDEESSPSDSLRHRYLRSPCSNRGTLGMKFTVVDTSLATGGKLCDLRNLNAECLVVSEPKARLEAKDSSVLKNSLDSQNVEKSQVRPLDAKNHVDDPMRFTIVDTSVDHCEKLSGFRRWRCLPSDDTRRGHVGADSGIKEEKTLEKAKDPSKRVIKPRSTPRAETNYYAVDSAPYLKRRRLSACISRESPVSKHLPGDNDTKMTICLESEQQSICVVQQQTSTCEEMNQDKEIVPLVEHMNLKSDQSKKTGTGLSSSLVEIQETTAIEPSGLNSNTGVDKNCSPEKIRTAHELISAEPKTNGICSVSELDKKRASSDLEQKQVFELPSISGSNNRSPSNDLGTSQEMGSSEQQHNQQIKTDGPRRQSTRKRPLTTRALEALESDFLITKRMKSTTKPEPRKHESSTKKKRSAKACNRNGSADLEHRGEDRSSFTKKSPTSKPLDQIEDSKPSYLLNEARTESKALDQVQESRPVLTEYRKLPPIVLKLPFRRG
Protein: Carboxylic ester hydrolase (EC 3.1.1.-) (A1ZA98)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Epoxide hydrolase
- Epoxide hydrolase
- Epoxide hydrolase
- Juvenile hormone acid O-methyltransferase
- LD24657p
Sequence:
MIQQRMLQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQKNYLLPTPVVYGDEDCLYLNVYRPEIRKSALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFANAPDAYQGFEVHVASEFQTDRVNLWSHILNEK
Protein: DNA ligase (EC 6.5.1.1) (F7FP17)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTLAFKTLFPRNLCALGRKELCLFSEQHHWPAIRQFSQWSETNLLCGCCLLQRRKPVLSFQRGHLRPRATHLISWSGSHVGLCTGPCEMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQISQHIADLSSKTAATPKKKATVQAKLTTTGQVTSPVKGASFITSTNPRKFSGFSAAKPNNSEQDPSSPAPKTSLSASKCDPKHKDCLLREFRKLCAMVAENPSYNTKTQIIHDFLQKGSTGDGFRGDVYLTVKLLLPGVIKSVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQSKSFPPAAKSLLTIQEVDAFLLHLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNEQEVEKDPGRRRALSVQASLMTPVQPMLAEACKSIEYAMKKCPNGMFSEIKYDGERVQVHKKGDHFSYFSRSLKPVLPHKVAHFKDYIPKAFPGGQSMILDSEVLLIDNNTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIRNRIMFSEMKQVTKASDLADMINRVIREGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHDDATLARLQKELDMVKISKDPSKIPSWLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKDKADFAVVAGDEGSSTTGGSNGENEGTAGSTVPRKGPKGPPSKSSASAKKTEQKLNDPSSRGGNTLIPKLSPMKPGEKLAVKSSPVKVGMKRKAADETPGLTKRRRASRQRGRRAMRTGRR
Protein: AT28425p (Q8T957)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSDYGARPKKPMSAFMLWMNSTGRKNIRAEHPDFSVQEVSVKGGEMWRAMADEHKIVWQESASKAMAEYKEKLEKWNAFKEHQTEVCLSQSFPHIYEAPLSSRFSKTNQRPTLFVYDSKDEAMAPICRTCFSKAKCFH
Protein: Tyrosyl-DNA phosphodiesterase 1 (E7EPD8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKISPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPNDGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSAFAPAKRIKDEVEASFSGSRQFQSETEVLRWQPGANGHLSCAI
Protein: CID domain-containing protein (Q8I4J5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MVVLTSDVVYSRLQDVKNPTQEAIETMSMWIMHYKDNASIDLIVDGWLNCFKTAGTDNKRIALFYVMNDVVQKAKMKHADTLIPAFQPAVLTAVGIGRKQDKVKAVMKRCIQIFKSRNVFSPASTTAMENLLGYEAEDQALEVDSDDLVKKITNFISARNVVADMMKCVNEGNFDYKEMCKHGMRDREEGGHILHEVHEAIDTMVQVRHSMEDQKKKMMALSETLELAKRVFLHQKREVLVVEEAYVNFRDGIKAVHTELLDMEAKKVYPGLLSPRNEDDRQTYGRSNNRSLSQQWGDNRNQIDMEMDEDERPQAPMMKPSLQALVGIASQPSLQSRIMQLGLKKIANGDEEMFQPTTTTTADTPLPSTFQPPPSKPAVINASKFSMPPPAITSAPLSDPRIRSDGEGPSQYAIALKQHGLPPPTGQQPVQNRMNAPPPAQPSPYQAIPQKPVEQTVYQGQFGGARDPRLANSVTPQSVAVAQQPPITGYQAQYEQIRDPRILQQAAPQQGYQATFEVQKPQLVSPQIQNNGYQARFEQSQLSPSIPQHQPVGQYHQQKNTYCQPPPQHHQYQQQSQQSHGYSSDYHSGDRRDDRGRDNYQNSRYDDRRGSSAPYNNQRGDRWRGSGSHHNDRNRNSGRDSWRGGNHRSGGGYHRY
Protein: ATP-dependent RNA helicase (Q3BQH9)
Organism: Xanthomonas euvesicatoria pv. vesicatoria (strain 85-10) (Xanthomonas campestris pv. vesicatoria)
Interaction partners:
- 30S ribosomal protein S1
- Ribonuclease D
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS11
- Transcriptional regulator HrpG
- HrpF protein
- Elongation factor G
- Small ribosomal subunit protein uS5
Sequence:
MSAIDSTLADTLRERRRAVDGAMSRDRGRLLGLWSRWQGKPGNPQVRDAFEQALAASQAQRQARAEQQPAITLDDQLPIAREAERIIALIRNHQVVVIAGETGSGKTTQLPKLCLAAGRGAAGMIGCTQPRRIAARAVAARVADELKTPLGTTVGFQVRFTDRVSDQSRIKFMTDGILLAEIASDRWLSSYDTIIVDEAHERSLNIDFLLGYLKQLLRKRSDLKLIVTSATIDTERFARHFDDAPVISVEGRTFPVEVRYRPLEGDTGDSDDGEHGSGRDGERSVNDAIVAAIDEITRIDPRGDVLMFLPGEREIRDAHQSLERRKYRETEVVPLYARLSAADQDRVFNPGPRRRLVLATNVAETSLTVPRIRYVVDPGLARVKRYSPRQKLDRLHIEPISQASANQRMGRCGRIAEGICYRLYAEADFAARPAFTDPEIRRSSLSGVILRMLQLGLGRIEDFPFLEAPDERALADGWQQLLELGAIDAQRRLTATGRQMARLPVDVKLARMLVAAQQHGCLREMIIIAAFLGIQDPRERPPEAREAADNAHALFADARSEFVGILRLWDAYRQVHEDLTQSKLRDWCNRHFLGFLRMREWRELHRQLRLLCEELGWSEEPANVMLAPLLAGASAPAREDGHSVNRPTRGQLHRAARLAREGKPDPNAAPVQPAPAATNKQAEAAEASARTTERERAAAYQALHRALLAGLPTQIGHRTEKGDYLAARQRRFVPFPGSALARKPPPWILAATLLDTQKVWGMTNAAIEPDWAIAELPHLLARKHFDAHWSRAQGQVVASEQISLFGLVLAPKKPVHFGKIDPAAAHDLFVRQGLVTGEINTRAAFVADNLKVLEQAREEEAKLRRAGIVADEGWQARWYLDRIPAELHSASGLDAWWKTLPPDKRRSLHWSLNDLLPGEGSEADRFPKYFPLGDARLPLHYRFEPGAIDDGVTLEVPLHLLNALDPARLSWLAPGFVADKASALIRSLPKAQRRNYVPAPDFGRAFYEAFSIASADDIRGELARFLTKATGTQVTALDFDEQALDTHLLMNLRLRDDDGKVLAESRDLDGLRARFGERAGQAFAARAGRALAAEGLRDFPSAPIPEQVAGEAGVPAYPALVDQGDNAALHIFADRNDAARAHPRGVRRLLEIALADKIKQARKQLPVSPKTGLLYAAIESQERLRGDLVDAALNAVLADGLGAIRDPGAFAQRRDDAGKRLFGEAMERLKLAESILGAVAELKPLLEAPLMGWARGNLDDMEQQLRALVHAGFLRDTPADALANYPRYLRAMILRTERAKRDPARDQARMLELKPFVDAVEAAAAHGLQDRQEWQALRWDLEELRVSVFAQELGAKSGVSAKKLSQRVAALRS
Protein: Protein Shroom (A1Z9P3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds to Rho-kinase Rok and targets it to the apical cell cortex where it mediates apical constriction. During embryogenic axis elongation, required for the localization to adherens junctions and the establishment of planar polarization of both Rho-kinase Rok and myosin regulatory light chain sqh. May be involved in the assembly of microtubule arrays during cell elongation (By similarity).
Subcellular location: [Isoform D]: Cell junction, adherens junction {ECO:0000269|PubMed:20549743, ECO:0000269|PubMed:22493320, ECO:0000269|PubMed:24535826}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16684770, ECO:0000269|PubMed:20549743}. Note=In adherens junctions, enriched in discrete spots and in tricellular junctions (PubMed:20549743, PubMed:22493320). In adherens junctions, localization requires Rho1 GTPase activity and interaction with the F-actin cytoskeleton (PubMed:20549743, PubMed:24535826). {ECO:0000269|PubMed:20549743, ECO:0000269|PubMed:22493320, ECO:0000269|PubMed:24535826}.; SUBCELLULAR LOCATION: [Isoform F]: Apical cell membrane {ECO:0000269|PubMed:20549743}; Peripheral membrane protein. Note=Localization to the apical cell membrane depends on N-terminal region (PubMed:20549743). Excluded from the lateral membrane (PubMed:20549743). {ECO:0000269|PubMed:20549743}.
Interaction partners:
- Rho-associated protein kinase
Sequence:
MKMRNHKENGNGSEMGESTKSLAKMEPENNNKISVVSVSKLLLKDSNGANSRSSNSNASFSSASVAGSVQDDLPHHNSSSSQLGQQHGSSLDQCGLTQAGLEEYNNRSSSYYDQTAFHHQKQPSYAQSEGYHSYVSSSDSTSATPFLDKLRQESDLLSRQSHHWSENDLSSVCSNSVAPSPIPLLARQSHSHSHSHAHSHSNSHGHSHGHAHSASSSSSSNNNSNGSATNNNNNNSSESTSSTETLKWLGSMSDISEASHATGYSAISESVSSSQRIVHSSRVPTPKRHHSESVLYLHNNEEQGDSSPTASNSSQMMISEEANGEESPPSVQPLRIQHRHSPSYPPVHTSMVLHHFQQQQQQQQDYQHPSRHHTNQSTLSTQSSLLELASPTEKPRSLMGQSHSMGDLQQKNPHQNPMLGRSAGQQHKSSISVTISSSEAVVTIAPQPPAGKPSKLQLSLGKSEALSCSTPNMGEQSPTNSIDSYRSNHRLFPVSTYTEPVHSNTSQYVQHPKPQFSSGLHKSAKLPVITPAGATVQPTWHSVAERINDFERSQLGEPPKFAYLEPTKTHRLSNPALKALQKNAVQSYVERQQQQQKEEQQLLRPHSQSYQACHVERKSLPNNLSPIMVGLPTGSNSASTRDCSSPTPPPPPRRSGSLLPNLLRRSSSASDYAEFRELHQAQGQVKGPSIRNISNAEKISFNDCGMPPPPPPPRGRLAVPTRRTSSATEYAPMRDKLLLQQAAALAHQQHHPQQHRHAQPPHVPPERPPKHPNLRVPSPELPPPPQSELDISYTFDEPLPPPPPPEVLQPRPPPSPNRRNCFAGASTRRTTYEAPPPTAIVAAKVPPLVPKKPTSLQHKHLANGGGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTAHDNVIASNLESNQQKRSNSKASYLPRQSLEKLNNTDPDHGIYKLTLTSNEDLVAHTKPSYGVTGKLPNNLPDVLPLGVKLHQQPKLQPGSPNGDANVTLRYGSNNNLTGNSPTVAPPPYYGGGQRYSTPVLGQGYGKSSKPVTPQQYTRSQSYDVKHTSAVTMPTMSQSHVDLKQAAHDLETTLEEVLPTATPTPTPTPTPTPPRLSPASSHSDCSLSTSSLECTINPIATPIPKPEAHIFRAEVISTTLNTNPLTTPPKPAMNRQESLRENIEKITQLQSVLMSAHLCDASLLGGYTTPLITSPTASFANEPLMTPPLPPSPPPPLEPEEEEEQEENDVHDKQPEIEELQLMQRSELVLMVNPKPSTTDMACQTDELEDRDTDLEAAREEHQTRTTLQPRQRQPIELDYEQMSRELVKLLPPGDKIADILTPKICKPTSQYVSNLYNPDVPLRLAKRDVGTSTLMRMKSITSSAEIRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLETRQQERGALESKRDLLYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDALVQSDC
Protein: Acetylcholine receptor subunit alpha-type des-2 (O76554)
Organism: Caenorhabditis elegans
Function: Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11273652}; Multi-pass membrane protein {ECO:0000269|PubMed:11273652}. Note=Enriched in the sensory endings of sensory neurons.
Interaction partners:
- Resistance to inhibitors of cholinesterase protein 3
- Acetylcholine receptor subunit alpha-type deg-3
Sequence:
MLIIIQSLLLATTASLCIADTPVPTQIRLVHDLLDNYDKKAKPMWDNSKPINVSFSMDLYQILELNEPQQYILLNAWIIERWFDEFLYWNPDDYENITELRLPYDSIWLPDTTLYNSLVMKDDDTRRLLNSKLTTDTHRRAALIELLYPTIYKFSCLLDLRFFPFDVQVCTMTFSSWTYDQKGIDYFPYSDKIGTSNYLENEGWYILQTKIKRQEVKYACCPNNYTLLQLTLYLRRKPLFYLVNLIIPTSIITLIAIVGFFTTSSASGMREEKVSLGITTLLSMSILMLMVSDQMPTTSTFIPLIGWFILAMIIVISLGTVVSSVIIAIQKRGSLGERMSKRALKFAKVLAWFTCTSLPPHVEKEHMMEAFDAPTPLVEVRPLQLASVKESVRNKWVSGARRATQRGNSGLALISDKSTDPLIHLSPTAHQPDESISPSAPPVPSSSPLPPPLTPGPADDVVSVASELSSKFLTSRMRPKSQKDNTFAAMQSSIKANRQLAVAEFEWFATVVERTCFVIFVVAFLIITFGINFIGFIHWHQAGVEYGG
Protein: Wdr36 protein (Q8VDN1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
TRPVREFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCLIDCFLLDSAPLNVTMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPPDYVPSIVMLPGTCQTQGMEDLEEKTEPSDEMIEYESPEQLSEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPQSAPFFIPTVPGLVPRFAVPEPSSDPQQSKVVNLGILAQKSNFYLKLEEGLLNNQYEAALNLLKELGPSGIETELRNLSPDDGGSVEVMRSFLSMIGMMLDRKRDFELAQAYLALFLKLHLRTLPSEPALLEELVKLSSQVEKDWTHLQSLFNQSMCVLNYIKSAFL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9VDJ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEHPKTGTETALEACDYFVDEVIEASSIRDAREEVRQIKHGELRTAVISGDERTVRVLLAALGTERQIIVNMAPSGANTLLFLACQSGYESITQRLLDAGADGRSHAVTKYSPLYAAVHSGHLGIARLMLDHFPELIQQPTVERWLPLHAACINGHIKLLELLISYSYPDYLYQTYRDEEGQWEWRLPFDANAHDVTGQTSLYIASILGNKQLVGVLLKWQLHCRRTLGDSASSVSTPITPTRKRISFGIQAIMSKLHISGESEGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGGHLDVVQSLLQHGANPNIVAKPVEDHNDPKCCEEIYGLSNVPIAEACKQRSLAMLDLLLKHGARDDNGTAIGMAITCGDEAILSRLLARRVHPDSDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVPWMVSGVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLTSIPQELFHLVSLRYLNVAQNKITDLPAPIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNKLQQLPFDLWRAPKLRELNVAFNLLRDLPVPPMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFTSIPAALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTNNCLKEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKHKTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANISTVGVDIGTWICEKRKRAPGSHGPVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFIAIPDAEKIGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSKEPMLLQKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDATLRDYYFLDPQWLCDMLAHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNMLCCCLVGEAIWMGDVSGNLHAYSTSTYAHLFSYMLDPNIKSAVISLVYMEKIARVAVGTHNGRVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAACSVVVDGIYELWCGEIAGKINVFPLNENGVSGHQALCHSEEPNLIEDVKVARMCSNESHVFSCLYPGCMVYQWDVISKRIENKLDCSKLLPCSESLQSIAIDEHVNLIKCQISALAAHNSELYIGTTWGCLIVAELHTLRPISVFRPYENEIKSIITLSKDNVPLIATIGRRYRSLISRYVDSAESSTKSSAVSTPTHGAAKSVPPADVDNHIHCLLWRAKHWT
Protein: NAC family protein (Wood-associated NAC domain transcription factor 1B) (B9GIS7)
Organism: Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)
Interaction partners:
Sequence:
MPEDMMNLSINGQSQVPPGFRFHPTEEELLHYYLRKKVANEKIDLDVIREVDLNKLEPWDIQEKCKIGSTPQNDWYFFSHKDKKYPTGTRTNRATAAGFWKATGRDKIIYSGFKRIGLRKTLVFYRGRAPHGQKSDWIMHEYRLDDSTNDTNVSNPIGEAIPEEGWVVCRVFRKKNYQKTLESPKSSSCSLDSKAHQILGSGNDGVLDQILLYMGRTCKMENETFSNMNISNNNSSLRFLSDNSISDGLHERFMHLPRLDSPPLPSIPLSSPSFDQDRSFKSCYHQSYDEMLTENEPSSSNQIGNGTFDMISSSVIHGSKSGQLNDWVTLDRLVASQLNGHEAETSKHLSCFTTGPNASFGLSPDDDMQLSHLQNSHRSSSNIQANTSHVYTNENDLWGFTKSSSPSSSSDPLCHLSV
Protein: Regulator of nucleoside diphosphate kinase (P0AFW4)
Organism: Escherichia coli (strain K12)
Function: May act as an anti-Gre factor. Regulates the level of the nucleoside diphosphate kinase Ndk.
Interaction partners:
Sequence:
MSRPTIIINDLDAERIDILLEQPAYAGLPIADALNAELDRAQMCSPEEMPHDVVTMNSRVKFRNLSDGEVRVRTLVYPAKMTDSNTQLSVMAPVGAALLGLRVGDSIHWELPGGVATHLEVLELEYQPEAAGDYLL
Protein: Growth hormone (Q0QBH1)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MMAAGPRTSLLLAFTLLCLLWTQVVGTFPAMSLSRLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTGNNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDVTPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
Protein: Phosphofurin acidic cluster sorting protein 1 (PACS-1) (O88588)
Organism: Rattus norvegicus (Rat)
Function: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:9695949}. Note=Localizes in the perinuclear region, probably the TGN. {ECO:0000269|PubMed:9695949}.
Interaction partners:
- WD repeat-containing protein 37
- Furin
Sequence:
MAERGGAGGGPGGAGGGSSQRGSGVAQSPQQQPPQQPSQPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGPGPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQGSKRILRSNEIILPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKVKSTWIKNQDDSLTETDTLEITDQDMFGDASTSLVVPEKVKTPMKSSKADLQGSASPSKVEGTHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGSQSYLSSILRFFVKSLASKTPDWLGHMRFLIVPLGSHPVAKYLGSVDSRYSSTFLDSAWRDLFSRSEPPVSEPLDVVGRVMQYVNGATTTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPHAGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQLAAQWPTHVKHFPVGLFSGSKPT
Protein: E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Praja-2) (Q63364)
Organism: Rattus norvegicus (Rat)
Function: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. Plays a role in ciliogenesis by ubiquitinating OFD1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7623148}. Cell membrane {ECO:0000250|UniProtKB:O43164}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:7623148}; Peripheral membrane protein {ECO:0000269|PubMed:7623148}. Golgi apparatus membrane {ECO:0000269|PubMed:7623148}; Peripheral membrane protein {ECO:0000269|PubMed:7623148}. Synapse {ECO:0000269|PubMed:7623148}. Postsynaptic density {ECO:0000269|PubMed:7623148}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O43164}. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus (By similarity). Expressed in the postsynaptic density region of synapses (PubMed:7623148). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane (By similarity). {ECO:0000250|UniProtKB:O43164, ECO:0000269|PubMed:7623148}.
Interaction partners:
Sequence:
MSQYTEKEPSVMDQDSSKAAWPRAAGGYQTITGRRYGRRHAYVSFKPCMTRHERSLGRAGDDYEVLELDDVAKENTAGSSSLDQVHPSLPSETTVEKSETEIPTCGPALNQSTESNPSVATVCHSEEVRETLDSSTNLQNHAERECTPAVCNASSVQNGIVLVHTDSYDPDSKHDENDSLQLCAQAVEGGRRQKVLGNAVFELENGEVERYADLCPSVPSLSGEIREESEELGSALLEKNSAGDAEAVHQDGQEFQRSSEDGIVRKRRQDDTDQGRQTENSTEDADCVPGHVEQNTSERANHHGSSPEQVVRPKVRKVISSSQVDQESGFNRHEAKQRSVQRWREALEVEECSSDDPIIKCDDYDGDHDCMFLTPSYSRVTPREAERHRATAENGATASGRQEARENAFWNACGEYYQLFDKDEDSSECSDGEWSASLPHRFSGTEKDQSSSDESWETLPGKDENEPELQSDSSGPEEENQELSLQEGEQTSLEEGEIPWLQYNEVNESSSDEGNEPANEFAQPEAFMLDGNNNLEDDSSVSEDLDVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWLQKSGTCPVCRRHFPPAVIDASAAASSEPDLDASPANDNAEEAP