wanglab/gogpt-training-data huggingface dataset:
Protein: RAB11 family interacting protein 2 (D3ZD48)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Recycling endosome {ECO:0000256|ARBA:ARBA00004172}.
Interaction partners:
- Ras-related protein Rab-11A
- Unconventional myosin-Vb
- Ras-related protein Rab-11B
- EH domain-containing protein 1
- Rab11 family-interacting protein 5
- Rab11 family-interacting protein 1
- RAB25, member RAS oncogene family
- EH domain-containing protein 3
- Rabenosyn, RAB effector
- Rab11 family-interacting protein 4
Sequence:
MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLMQGNPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKSDGVFSDTSSAIVPSTHMPDANPEFSSGEMQMKSKPKKPFLLGPQRLSSAHSMSDLTGSHLSSEKLKSSTVGPTHLLSHQINSFGVVPESGSLKSPHRRTLSFDTSKLNQPGSIVDEGEHCFGRQSDPFTNVTASLPQKFATLPRKKNPFEESSEPWDSSTNLFSKPIEVRKESKREKREKVSLFERVTGKRDSRRSDKLNNGGSDSPCDLKSPSAFNENRQDYFEYESTNPFTAKFRASTIMPSSSFHMNPTSSDDLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAVYSQEHLSPGPPHLCGEAISTQS
Protein: Transmembrane protein 9 (B1ALM5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MKLLSLVAVVGCLLVPPAEANKVRESSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHKMLS
Protein: Protein phosphatase 1 regulatory subunit SDS22 (P22194)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for the mitotic metaphase/anaphase transition. Positively modulates protein phosphatase-1, possibly by forming a repeating helical rod that is capable of enhancing a PP1-dependent dephosphorylation activity.
Subcellular location: Nucleus.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-1
- Serine/threonine-protein phosphatase PP1-2
- Type 1 phosphatases regulator ypi1
- Uncharacterized protein C17A5.09c
- Dynein heavy chain, cytoplasmic
- Serine/threonine-protein phosphatase PP-Z
- Uncharacterized protein C227.15
- UBX domain-containing protein 3
- Cell division cycle protein 48
- Aurora kinase
Sequence:
MSNVSSEDGIAPETQLIIDDPDVQQIDADEDLLDDVPDDVDCVELIQSRIQSMASLGLERFKNLQSLCLRQNQIKKIESVPETLTELDLYDNLIVRIENLDNVKNLTYLDLSFNNIKTIRNINHLKGLENLFFVQNRIRRIENLEGLDRLTNLELGGNKIRVIENLDTLVNLEKLWVGKNKITKFENFEKLQKLSLLSIQSNRITQFENLACLSHCLRELYVSHNGLTSFSGIEVLENLEILDVSNNMIKHLSYLAGLKNLVELWASNNELSSFQEIEDELSGLKKLETVYFEGNPLQKTNPAVYRNKVRLCLPQLRQIDATIIPKTSKQFP
Protein: Transcriptional activator MN1 (D3YWE6)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for normal growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull. May play a role in tumor suppression (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q10571}.
Interaction partners:
Sequence:
MFGLDQFEPQINSRHAGQGEGNFNEAGLSMNAHFKAPAFHAGPPTGPVDPAISALGEPPILGLNMEPYGFHARSHSELHAGGLQAQPVHGFFGGQQPHHSHPGGHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAAGGLGSQPPFAESYEHMAESQGPEGFGPQRPGNLPDFHSSGTSGHAVPAPCLPLDQSPNRAASFHGLSASSGSDSHSLEPRRVTNQGAVDSLEYNYPSEPPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRASGMVGLSKMHSQPPQPPPQQQQPQHGVFFERFGGARKMPVGLEPAVGSRHPLMQPPQQAPPPPQQPPPQQQPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNGTLDNQLSPSAYPGLPGEFTPPVPDSFSSGPPLQHPGPDHQSLQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHGGSVGGLAQTNFEREGGSAGAGRLSGFEQQAPHLAQESAWFPGPHPPGDLLPRRMGGAGLPTDCGPHDPALAPPPAPGGSGVLFRGSLQEPLRMPGEGHVPALASPGLQFGGSLAGLGQLQSPGAGVGLPNAPSERRPPPPDFPAPALGGQPGFPFGSGSRQATPHSAPGVNSPPSAGSGSSGAGGGAYPPQPDFQPSQRNSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNEPDSAVAAGNPGSDYFPGGTTPGAPGPGGPSGTSGGGSKASGPPNPPIQGDSTSLSPNYTLESTSGNDGKPVPGGSGRGRGRRKRDSGHVSPGTFFDKYSTAPDSGGAPGVSPGQQQAPGSAAGGSSVNEARGPTPHEKALTSPSWGKGAELLLGDQPDLMASLDSTAKSDGSSPHVGEFASDEVSTSYANEDEVSSSSDNTTALAKASRSPLVTSSPKLPPRGVGAGEHTPKASALGLGILSTSTSTPDSYGGGVGTGHPGTPGLEQVRTPTSSSGAQPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGSKKAECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSTTWYMPPDKALVDGGDEDKTLAPWEKAKSQNPNNKEAHDHPTNKASATQPGSHLQCLTVHCTDGDPKARTSVPTWRSLHSDISNRFGTFVAALT
Protein: Cinnamyl alcohol dehydrogenase 7 (OsCAD7) (EC 1.1.1.195) (Protein FLEXIBLE CULM 1) (Q0JA75)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in lignin biosynthesis. May catalyze the final step specific for the production of lignin monomers, like coniferyl alcohol, sinapyl alcohol and 4-coumaryl alcohol.
Interaction partners:
- Aldehyde dehydrogenase 1
- Os06g0592400 protein
- Os05g0553700 protein
- Os09g0359700 protein
- Os08g0545200 protein
- Peroxidase
- Aldehyde dehydrogenase 1
- Peroxidase
- Os03g0235000 protein
- Threonine dehydratase
Sequence:
MAPTTTATAAAEQAPPPQHTRKAVGLAAHDDSGHLTPIRISRRKTGDDDVAIKVLYCGICHSDLHTIKNEWRNAVYPVVAGHEITGVVTEVGKNVARFKAGDEVGVGCMVNTCGGCESCRDGCENYCSGGVVFTYNSVDRDGTRTYGGYSDAVVVSQRFVVRFPSSAGGGAGAALPLDSGAPLLCAGVTVYAPMRQHGLCEAGKHVGVVGLGGLGHVAVKFARAFGMRVTVISTSPVKRQEALERLGADGFIVSTNASEMKAAMGTMHGIINTASASTSMHSYLALLKPKGKMILVGLPEKPLQIPTFALVGGGKILAGSCMGSISETQEMIDFAAEHGVAADIELIGADEVNTAMERLAKGDVRYRFVVDIGNTLRSD
Protein: Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD(+)-specific ICDH) (O13696)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Isocitrate dehydrogenase subunit 2, mitochondrial
- Aconitate hydratase, mitochondrial
- Probable isocitrate dehydrogenase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Homoisocitrate dehydrogenase
- Aspartate aminotransferase, mitochondrial
- Glutamate synthase
- Probable citrate synthase, mitochondrial
- Probable NAD-specific glutamate dehydrogenase
- NADP-specific glutamate dehydrogenase
Sequence:
MFKSLVRKSSAFQPLKYGGKYTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVTGMEKNNKSSGDALHEAIQSLKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLEHQSVPGVVESLKIITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERMESL
Protein: LSM family member 14B (Protein LSM14 homolog B) (F1Q898)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- RNA helicase
- Enhancer of mRNA-decapping protein 3
- Eukaryotic translation initiation factor 4E nuclear import factor 1
- RNA helicase
- m7GpppN-mRNA hydrolase
- ATP-dependent RNA helicase
- Importin subunit alpha
- ATP-dependent RNA helicase
- 40S ribosomal protein S27
- Polyadenylate-binding protein
Sequence:
MSSGTPYIGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEGRPTDRPVPARDEIFEYIIFRGSDIKDITVCEPLKVHHGLPQDPAIVQSSVGTSSVHYPSQSSYSPYRGVLPAYNQLAASSLFSQQYAAALGLGLHGVSGRRGPMVEQAVQTVPAEKTQQQQQQKKSLGGGQQGGAQRGARAQRGDSSSAQQAVLKGQSPANNENKPPTSRRKPGTRRSRNRGQGQLLVGSTKPSTLQFEADFDFETANAQFNKDDLEKEIEDQNSVQEPRSPPEEHSAVEQQKQDSEHESAAEDDPLGPKCFYNKAKSFFDNISSELRSRRTTWAEERKLNVETFGVPGRYLRAGGFRGFGGRRGRGAAQRTLTHRAGSARV
Protein: Probable inactive E3 ubiquitin-protein ligase SINAT6 (Protein SEVEN IN ABSENTIA 2) (Seven in absentia homolog 6) (Q93WE4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable inactive E3 ubiquitin-protein ligase that plays a role in regulation of autophagy. Upon starvation, involved in maintaining ATG6 homeostasis by competitively associating with ATG6, a component of the autophagosome complex. Acts as positive regulator of drought stress response. Functions as positive regulator of abscisic acid-mediated stomatal closure.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24350984}. Nucleus {ECO:0000269|PubMed:24350984}.
Interaction partners:
- TNF receptor-associated factor homolog 1a
- TNF receptor-associated factor homolog 1b
- Cyclin-dependent kinase G1
- Autophagy-related protein 13a
- 26S proteasome non-ATPase regulatory subunit 13 homolog B
- Cytochrome c-type biogenesis protein CcmE homolog, mitochondrial
Sequence:
MEPRINDLQVESRVHELLDFPVHTNQISSAIYECPNDHIENPKKKPYNCPHSGAKCDVTGDIQRLLLHLRNDHNVEMSDGRSFSHRYVHHDPKHLHHATWMLTLLDCCGRKFCLYFEAFHLRKTPMYMAFMQFMGDEEEAMSFSYSLQVGGNGRKLTWQGVPRSIRDSHKTVRDSQDGLIITRKLALFFSTDNNTTDKELKLKVSGRVWREQPVSI
Protein: Uncharacterized protein C63.14 (Q9Y7U0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable sphingolipid long chain base-responsive protein pil2
- Zinc metalloprotease mde10
Sequence:
MSTLGNSTVKPTNAEFPGLHAMERYKPATSESLYVKGHYGPHPHKEHPAAYVAAKTGFNATSRRQSVREHHSSHEGSAQLNPDRILYMSAGAVTAAVPNKEHTDNVTTSQTIRYETSSQPSQEVYHPHAGKAAQSAHVMNSTESRPSSAHVSSSYTQKPFAFPLGPVFATSSQAAASETALPSGYEPDEARFIGASQLAKLSASHAHQTPAQTVDDDVPLPTRMAATELVGHIPLRAANYANEYSQDVPASTHRAASELVHGVPMRASGINDPKHDLDAATRHNINSVAAASYVAARSRVIEEEEEPPNEVKERMDYEADAQRRIRKMNVFGSAGAALRERTQQDLMANEQEHSGEFAGFSRNLTNTAAAPTTYEYKRPTSSYTAKDATSKVYRSNTYKPKSSVNGSVYRSKSVKSTTSHNKVPERNSVPAYNEKLMHSSAANAAILSHKNYSPPVQPTRDDEVSQEDARVKEIVRGMKLPLTSSSLSAAAYRPMEKQDPATVERHHIQAEATQRVRDMKLDLTKLESKTNDEIRSYRPRNVVIKPYAAATPPKNIPSTYRAPQAPSVLSPVVTASEGDFELDGITPERQQTMTRSTYQESSQRPFHEDPFRTHPGLLQAVARNHRNSLANIDERIMRQNQAATANTNTVSETDIEALERRLSKAYRMEAQEEAYAINIGGGRVISPEELEEIARRNVDPMVSELSERAAQERERKEQAKEAKRLKKLAKEEKRLKKKEEKARKAEEKRLQKERAKYAKQMSRESAHADQAIANTGPVAPPYFEHETEPSHYEEEEEEEPEERREESSHFSESSGNNEFEETEQEYTHGYGNDVLVQRTDVVNNFGESSHAHDNAVNEKRDLGRNGFGDVDEQDATEVYRHSIERIVPGDYLHDEKTRDTLTRESPAFRSEEAVVEVADEDHPHASEAERAHSYSNRKQASSESSPESQSTHYNDYEGTEDNIVRQTTTVDEDGHQEQTTSTTKVAHPIPVSNGLSSPPRERLDDNAKEILSRSSPKSPVAWFKRKFKNRKDKAAVKRMLEEDSSKQLSSGRDVVAPTSVNHDVSHVGESTKPAVNNSTKPVAVTSKNGHSRNGSHAAHSNNVIGTQPHVNVSAVPNTGNLKDALEGSAVSKTDDVDNVVSGHSNVNGVSKSRPNIVERSEDYVISHLPEQSRAPIGAAFQEDL
Protein: Bradykinin-potentiating and C-type natriuretic peptides (Brain BPP-CNP) (bBPP-CNP) (Evasin-CNP) [Cleaved into: Bradykinin-potentiating peptide 13a+QQWA (BPP-13a+QQWA); Bradykinin-potentiating peptide 13a+QWA (BPP-13a+QWA); Bradykinin-potentiating peptide 13a (BPP-13a); Bradykinin-potentiating peptide 10c+QQWA (BPP-10c+QQWA); Bradykinin-potentiating peptide 10c (BPP-10c) (BPP-2) (Evasin-10c); Bradykinin-potentiating peptide 12b (BPP-12b) (Evasin-12b); Bradykinin-potentiating peptide AP; Bradykinin-potentiating peptide APL (BPP-APL); Bradykinin-potentiating peptide 11e (BPP-11e) (Evasin-11e); Bradykinin-potentiating peptide 5a (BPP-5a) (Bradykinin-potentiating peptide Va) (BPPVa) (Evasin-5a) (Proline-rich peptide 5a) (Bj-PRO-5a) (PRO-5a); Poly-His-poly-Gly peptide 1 (pHpG-1); C-type natriuretic peptide (Bj-CNP)] (Q9PW56)
Organism: Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Function: Modestly inhibits ACE (with highest affinity for the N-site) and reveals strong bradykinin-potentiating activity. Induces nitric oxide (NO) production depended on muscarinic acetylcholine receptor M1 subtype (CHRM1) and bradykinin B2 receptor (BDKRB2) activation. Both these receptors contribute to the vasodilation induced by this peptide that may have an indirect action on BDKRB2 and a direct agonistic action on CHRM1.
Subcellular location: Secreted. Cytoplasm, cytosol. Note=BPP-10c is internalized in the cytosol of prey cells.
Interaction partners:
Sequence:
MVLSRLAASGLLLLALLALSVDGKPVQQWAQGGWPRPGPEIPPLKVQQWAQGGWPRPGPEIPPLTVQQWAQNWPHPQIPPLTVQQWAQWGRPPGPPIPPLTVQQWAQARPPHPPIPPAPLQKWAPVQKWAPLLQPHESPASGTTALREELSLGPEAASGVPSAGAEVGRSGSKAPAAPHRLSKSKGAAATSAASRPMRDLRPDGKQARQNWGRMVHHDHHAAVGGGGGGGGGGARRLKGLAKKGAAKGCFGLKVDRIGTMSGLGC
Protein: Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (RP13) (YS3) (P05750)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein eS10A
- Large ribosomal subunit protein eL24B
- Small ribosomal subunit protein eS27A
- Small ribosomal subunit protein uS14B
- Large ribosomal subunit protein eL19A
- Small ribosomal subunit protein eS7B
- Small ribosomal subunit protein uS11B
- Small ribosomal subunit protein eS4A
- Small ribosomal subunit protein eS1A
- Large ribosomal subunit protein uL6A
Sequence:
MVALISKKRKLVADGVFYAELNEFFTRELAEEGYSGVEVRVTPTKTEVIIRATRTQDVLGENGRRINELTLLVQKRFKYAPGTIVLYAERVQDRGLSAVAQAESMKFKLLNGLAIRRAAYGVVRYVMESGAKGCEVVVSGKLRAARAKAMKFADGFLIHSGQPVNDFIDTATRHVLMRQGVLGIKVKIMRDPAKSRTGPKALPDAVTIIEPKEEEPILAPSVKDYRPAEETEAQAEPVEA
Protein: Diadenylate cyclase (DAC) (EC 2.7.7.85) (Cyclic-di-AMP synthase) (c-di-AMP synthase) (A0A0H3GM48)
Organism: Listeria monocytogenes serotype 1/2a (strain 10403S)
Function: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes (Probable). Overexpression increases export of c-di-AMP. c-di-AMP is a second messenger that mediates growth, cell wall stability and virulence (Probable).
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01499}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01499}.
Interaction partners:
Sequence:
MDFSNMSILHYLANIVDILVVWFVIYKVIMLIRGTKAVQLLKGIFIIIAVKLLSGFFGLQTVEWITDQMLTWGFLAIIIIFQPELRRALETLGRGNIFTRYGSRIEREQHHLIESIEKSTQYMAKRRIGALISVARDTGMDDYIETGIPLNAKISSQLLINIFIPNTPLHDGAVIIKGNEIASAASYLPLSDSPFLSKELGTRHRAALGISEVTDSITIVVSEETGGISLTKGGELFRDVSEEELHKILLKELVTVTAKKPSIFSKWKGGKSE
Protein: Myosin light chain kinase isoform-II (O01653)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
FDSHSICSLINSGCSDCSSSGELCVLERDLRGQDEECVQLLKTPLPVVCASGDEALFYARVFPCDAEADWYLNGQLLAQADDSLNMTLESYPENGIRLLRMRDVTASRSGEICLQVKHPQAEFRRIPTTRTYTSLLVLPAIRGNSSSSSLAARSCILTRPEDCTALIGGHVRLSVRYEPFPGTKIIWYKACHPIVESSNVTIRTTSQQSTLYITDISADDSGKYTVEVMNDYGVEAAAASVAVEGPPEPPSGQPSVSLGPDRVAVAWCGPPYDGGCMITGFIIEMQTIGDENCDEDSWQQVTRVVDSLAYTVKNLQPERQYRFRVRAENIHGRSAPGQASELVQITNTPQRSTSSDASDRFGQATVSVQSGGDFKSRFEIIEELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKLLQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLASKWLSQRPDDSLSNNKICTDKLKKFIIRRKWQKTGNAIRALGRMANLSVSRRNSAIAMGVLSSPRPSISGLGMLTTSAIGSGTSSQMTSLHEEEDDFSGEMPPVEKRTVLKLRDKSQCSERSDSGYSECSNCSGAQETLLLSLAKSKLEAIAKASTLPTVVHDTEQPVSLELPTKGEAIMRSNFTNTIKMRKKSLEDSAARG
Protein: Short-chain dehydrogenase reductase 3a (AtSDR3a) (EC 1.1.1.-) (O80713)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Confers resistance to the incompatible pathogenic bacteria P.syringae pv. tomato DC3000 in a PR1-dependent manner. Seems not involved in abscisic acid (ABA) biosynthesis.
Interaction partners:
- FAD/NAD
- Protein DELAY OF GERMINATION 1
- PAS domain-containing protein
- Transcription factor bHLH57
- At3g48510
- 
- Emb|CAB62340.1
Sequence:
MSGLRLDGKIAIITGGASGIGAEAVRLFTDHGAKVVIVDFQEELGQNVAVSVGKDKASFYRCDVTNEKEVENAVKFTVEKYGKLDVLFSNAGVMEQPGSFLDLNLEQFDRTMAVNVRGAAAFIKHAARAMVEKGTRGSIVCTTSVASEIGGPGPHAYTASKHALLGLVKSACGGLGKYGIRVNGVAPYAVATAINSRDEETVRMVEEYSAATGILKGVVLKARHVAEAALFLASDDSAYVSGQNLAVDGGYSVVKPI
Protein: Prephenate dehydratase (PDT) (EC 4.2.1.51) (P9WIC3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Prephenate dehydrogenase
- Intracellular chorismate mutase
- Secreted chorismate mutase
- Aromatic amino acid aminotransferase
- Histidinol-phosphate aminotransferase
- Histidinol-phosphate aminotransferase Rv2231c
- Probable phosphoglycerate mutase
- Chorismate synthase
- Catalase-peroxidase
- DUF2470 domain-containing protein
Sequence:
MVRIAYLGPEGTFTEAALVRMVAAGLVPETGPDALQRMPVESAPAALAAVRDGGADYACVPIENSIDGSVLPTLDSLAIGVRLQVFAETTLDVTFSIVVKPGRNAADVRTLAAFPVAAAQVRQWLAAHLPAADLRPAYSNADAARQVADGLVDAAVTSPLAAARWGLAALADGVVDESNARTRFVLVGRPGPPPARTGADRTSAVLRIDNQPGALVAALAEFGIRGIDLTRIESRPTRTELGTYLFFVDCVGHIDDEAVAEALKAVHRRCADVRYLGSWPTGPAAGAQPPLVDEASRWLARLRAGKPEQTLVRPDDQGAQA
Protein: TBC1 domain family member 20 (Q9D9I4)
Organism: Mus musculus (Mouse)
Function: GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude (By similarity). Involved in maintaining endoplasmic reticulum structure (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Ras-related protein Rab-1B
- Ras-related protein Rab-1A
- Rab3 GTPase-activating protein non-catalytic subunit
- Ras-related protein Rab-18
- TBC1 domain family member 23
- Rab3 GTPase-activating protein catalytic subunit
Sequence:
MALRPSKGDGSAGRWDRGAGKADFNAKRKKKVAEIHQALNSDPIDLAALRRMAISEGGLLTDEIRCQVWPKLLNVNTSEPPPVSRKDLRDMSKDYQQVLLDVRRSLRRFPPGMPDEQREGLQEELIDIILLVLDRNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVSPELHDFMQSAEVGTIFALSWLITWFGHVLMDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQEAERTAASTFKDFELASTQQRPDMVLRQRFRGLLRPEARTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP
Protein: 2-dehydro-3-deoxy-D-arabinonate dehydratase (EC 4.2.1.141) (2-keto-3-deoxy-D-arabinonate dehydratase) (KdaD) (Q97UA0)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Participates in a pentose oxidation pathway that converts D-arabinonate to 2-oxoglutarate.
Interaction partners:
- 2,5-dioxopentanoate dehydrogenase
- 2-hydroxyhepta-2, 4-diene-1,7-dioate isomerase
- Dihydroxy-acid dehydratase
Sequence:
MHFIMMKLFRVVKRGYYISYAILDNSTIIRLDEDPIKALMRYSENKEVLGDRVTGIDYQSLLKSFQINDIRITKPIDPPEVWGSGISYEMARERYSEENVAKILGKTIYEKVYDAVRPEIFFKATPNRCVGHGEAIAVRSDSEWTLPEPELAVVLDSNGKILGYTIMDDVSARDLEAENPLYLPQSKIYAGCCAFGPVIVTSDEIKNPYSLDITLKIVREGRVFFEGSVNTNKMRRKIEEQIQYLIRDNPIPDGTILTTGTAIVPGRDKGLKDEDIVEITISNIGTLITPVKKRRKIT
Protein: Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] (P06399)
Organism: Rattus norvegicus (Rat)
Function: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P02671}.
Interaction partners:
- Prothrombin
- Fibrinogen gamma chain
- Fibrinogen beta chain
- Plasminogen
- Albumin
- Antithrombin-III
- Alpha-2-HS-glycoprotein
- Coagulation factor XIII B chain
- Serpin family F member 2
- Protein AMBP
Sequence:
MLSLRVACLILSLASTVWTADTGTTSEFIEAGGDIRGPRIVERQPSQCKETDWPFCSDEDWNHKCPSGCRMKGLIDEANQDFTNRINKLKNSLFDFQKNNKDSNSLTRNIMEYLRGDFANANNFDNTFGQVSEDLRRRIQILKRKVIEKAQQIQVLQKDVRDQLIDMKRLEVDIDIKIRSCKGSCSRSVSREINLKDYEGQQKQLEQVIAKDLLPAKDRQYLPAIKMSPVPDLVPGSFKSQLQEGPPEWKALTEMRQMRMELERPGKDGASRGDLPGDSRGDSATRGPGSKIENPMTPGHGGSGYWRPGSSGSGSDGNWGSGTTGSDDTGTWGAGSSRPSSGSGNLKPSNPDWGEFSEFGGSSSPATRKEYHTGKLVTSKGDKELLIGNEKVTSTGTSTTRRSCSKTITKTVLGNDGHREVVKEVVTSDDGSDCGDGMDLGLTHSFSGRLDELSRMHPELGSFYDSRFGSLTSNFKEFGSKTSDSDIFTDIENPSSHVPEFSSSSKTSTVRKQVTKSYKMADEAASEAHQEGDTRTTKRGRARTMRDCDDVLQTHPSGAQNGIFSIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDKGEGEFWLGNDYLHLLTLRGSVLRVELEDWAGKEAYAEYHFRVGSEAEGYALQVSSYQGTAGDALMEGSVEEGTEYTSHSNMQFSTFDRDADQWEENCAEVYGGGWWYNSCQAANLNGIYYPGGTYDPRNNSPYEIENGVLWVPFRGADYSLWAVRMKIRPLVGQ
Protein: Probable alpha-glucosidase AglA (Maltase) (Glucoinvertase) (Glucosidosucrase) (Maltase-glucoamylase) (Lysosomal alpha-glucosidase) (Acid maltase) (O53198)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Maltokinase
- 4-alpha-glucanotransferase
- Group 2 truncated hemoglobin GlbO
- Probable beta-glucosidase BglS
- Trehalose synthase/amylase TreS
- Uncharacterized glycosyl hydrolase Rv2006
- Uncharacterized transporter Rv1979c
- Probable cationic amino acid transport integral membrane protein RocE
- Possible cationic amino acid transport integral membrane protein
- Probable conserved integral membrane alanine and valine and leucine rich protein
Sequence:
MDQHQRPDPMGPGSPRASARRPEPDPMGEPWWSRAVFYQVYPRSFADSNGDGVGDLDGLASRLDHLQQLGVDAIWINPVTVSPMADHGYDVADPRDIDPLFGGMPAFERLVAAAHRQGIKVTMDVVPNHTSSAHPWFQAALADLPGSPARDRYFFRDGRGPDGSLPPNNWESVFGGPAWTRVREPDGNPGQWYLHLFDTEQPDLNWDNPEILDDFEKTLRFWLDRGVDGFRIDVAHGMAKPPGLPDSPDLGIEVLHHRDDDPRFNHPNVHAIHRDIRTVIDEYPGAVTVGEVWVHDNARWAEYLRPDELHLGFNFRLARTEFDAAEIRDAVANSLAAAALQNATPTWTLANHDVGREVSRYGGGEIGLRRAKAMAVVMLALPGVVFLYNGQELGLPDVDLPDEVLQDPTWERSGRTERGRDGCRVPIPWSGNIPPFGFSTCPDTWLPMPPEWAALTAEKQRADAGSTLSFFRLALRLRRERNEFDGDVDWLAAPDDALIFRRHGGGLVCALNAAERPLALPAGEPILASAPLTDATLPPNAAAWLV
Protein: Ubiquinone biosynthesis protein UbiU (P45527)
Organism: Escherichia coli (strain K12)
Function: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.
Interaction partners:
- Ubiquinone biosynthesis protein UbiV
- Ubiquinone biosynthesis accessory factor UbiT
Sequence:
MELLCPAGNLPALKAAIENGADAVYIGLKDDTNARHFAGLNFTEKKLQEAVSFVHQHRRKLHIAINTFAHPDGYARWQRAVDMAAQLGADALILADLAMLEYAAERYPHIERHVSVQASATNEEAINFYHRHFDVARVVLPRVLSIHQVKQLARVTPVPLEVFAFGSLCIMSEGRCYLSSYLTGESPNTIGACSPARFVRWQQTPQGLESRLNEVLIDRYQDGENAGYPTLCKGRYLVDGERYHALEEPTSLNTLELLPELMAANIASVKIEGRQRSPAYVSQVAKVWRQAIDRCKADPQNFVPQSAWMETLGSMSEGTQTTLGAYHRKWQ
Protein: Cytochrome c oxidase subunit 4 (Q9U329)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU367145}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU367145}.
Interaction partners:
- COX5B-domain-containing protein
- Cytochrome c oxidase subunit 3
- Cytochrome oxidase c subunit VIb
- Cytochrome c domain-containing protein
- Cytochrome b-c1 complex subunit 7
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase polypeptide VIIc
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 6A, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
Sequence:
MMLPRLALRAVHTTARLSGGQEFYWGPDKAAGRELVGYGANGDNIYQDRLDYWYPAIRFRKEDSVIAPIRAKEQADWKNLSAEEKKLLYRYSFRQTLSEFEAPTGYWKVISAVILSVLGLCTYYAVLLNVCVYPELPPTFQNEYKEAQVERALVLEKGQFLGAPTHYDYENKKWK