wanglab/gogpt-training-data huggingface dataset:
Protein: Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Protein F1) (P07936)
Organism: Rattus norvegicus (Rat)
Function: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}; Cytoplasmic side {ECO:0000250|UniProtKB:P17677}. Cell projection, growth cone {ECO:0000269|PubMed:10982410}. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}; Cytoplasmic side {ECO:0000250|UniProtKB:P17677}. Synapse {ECO:0000250|UniProtKB:P17677}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}. Perikaryon {ECO:0000269|PubMed:10982410, ECO:0000269|PubMed:12957493}. Cell projection, dendrite {ECO:0000269|PubMed:10982410}. Cell projection, axon {ECO:0000269|PubMed:10982410}. Cytoplasm {ECO:0000269|PubMed:10982410, ECO:0000269|PubMed:12957493}. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. {ECO:0000250|UniProtKB:P17677}.
Interaction partners:
- Calmodulin-1
- Calmodulin-like protein 4
- Synapsin-1
- Calmodulin-like protein 3
- Beta-nerve growth factor
- Neural cell adhesion molecule 1
- Synaptophysin
- Microtubule-associated protein 2
- Acyl-protein thioesterase 2
- Neurotrophic factor BDNF precursor form
Sequence:
MLCCMRRTKQVEKNDEDQKIEQDGVKPEDKAHKAATKIQASFRGHITRKKLKDEKKGDAPAAEAEAKEKDDAPVADGVEKKEGDGSATTDAAPATSPKAEEPSKAGDAPSEEKKGEGDAAPSEEKAGSAETESAAKATTDNSPSSKAEDGPAKEEPKQADVPAAVTDAAATTPAAEDAAKAAQPPTETAESSQAEEEKEAVDEAKPKESARQDEGKEDPEADQEHA
Protein: Ly49 stimulatory receptor 3 (Q8K3H4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSKQDVPCSTVRFKKSSGLQYQVRPEETQRPREAGWRVPWQLTVIATGILLSLRLVAVAMLVTNIFQYSNENHELQKTHKRQHNSSTMEKDIKLKEEMLRNMSVESVHYNAFLDLINREQNRWYKKTKTVLASPQHTGGCDEMHWFCYGIKCYYFTMDIRIWRECKQTCQNYSLSFLKIDDKDELKFLQDHIIRDNYWIGSSYNNKKKEWAWIDNSPFDLDFVARTLLRKTGYCLYFSMSGLHDDDCGKRYLCICEKGMDKFPAPLCSVKETSHSAV
Protein: Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) (P18090)
Organism: Rattus norvegicus (Rat)
Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12391161}; Multi-pass membrane protein {ECO:0000269|PubMed:12391161}. Early endosome {ECO:0000250}. Note=Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity). Colocalizes with RAPGEF2 at the plasma membrane. {ECO:0000250}.
Interaction partners:
- Natriuretic peptides A
- Beta-2 adrenergic receptor
- Guanine nucleotide-binding protein G
- Pro-opiomelanocortin
- Guanine nucleotide-binding protein G
- Pro-glucagon
- Guanine nucleotide-binding protein G
- Pituitary adenylate cyclase-activating polypeptide
- Guanine nucleotide-binding protein G
- Beta-3 adrenergic receptor
Sequence:
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
Protein: UDP-glucuronosyltransferase 1A9 (UGT1A9) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-9) (UDPGT 1-9) (UGT1*9) (UGT1-09) (UGT1.9) (UDP-glucuronosyltransferase 1-I) (UGT-1I) (UGT1I) (lugP4) (O60656)
Organism: Homo sapiens (Human)
Function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Also metabolizes mycophenolate, an immunosuppressive agent.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17179145}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- UDP-glucuronosyltransferase 1A3
- UDP-glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase 1A6
- UDP-glucuronosyltransferase 1A8
- UDP-glucuronosyltransferase 1A4
- UDP-glucuronosyltransferase 1A7
- UDP-glucuronosyltransferase 1A10
- Cytochrome P450 3A4)
- UDP-galactose translocator
- Cytochrome P450 2D6
Sequence:
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Protein: Protein anon-37Cs (P18487)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has a non-vital function.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MQCFKLASRRSLYNARVLQADNIGDKQRSPDLEAARQNTQIVVVGAGLAGLSAAQHLLSHGFRRTVILEATDRYGGRINTQRFGDTYCELGAKWVKIDGSQDSMYELLRNTEGLGKQIKQPDRATYLQDGSRINPAMVELIDTLFRQLCRGFKVSERVKTGGDLHSLDNVMNYFRTESDRIIGVSFQHPKDQLAAREIFQSLFKEFGSILGCCLEYVNIEHITKCPVQQEQRPLYVPTGLDNVVDDLIQNMDKAQLQTGKPVGQIQWTPAPMKSVGCLDGSLYNADHIICTLPLGVLKSFAGVLFRPTLPLDKMLAIRNLGFGNPLKIYLSYKKPIGRWLKGSLRPLGTLLNPSVEQQPERNWTQQVVEISQVPSSQHVLEVHVGGGYYEEIEKLPDEELLEQITGLLRRCVSSHLVPYPQELLRSNWSTSACYLGGRPYFSTNSSARDVQRLAAPLGEKSPGLLFAGDATSLRGFGTIDAARSSGIREAQRIIDYYLKSVHCG
Protein: Nucleolar GTP-binding protein 2 (G0SBX1)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU364023}.
Interaction partners:
- Nucleolar GTP-binding protein 1
- Putative GTP binding protein
- Ribosome biogenesis protein NSA2 homolog
- Ribosome biogenesis protein NOP53
- Ribosome biogenesis protein RLP24
- Ribosome production factor 2 homolog
- Pescadillo homolog
- Zinc finger domain-containing protein
- Putative curved DNA-binding protein
- Uncharacterized protein
Sequence:
MGTGKKEKNRLLREGRTPGDPHVKGENFYRSAKKIKTLNILKEGKPIRDSKGKIVKAASFQSKEVPKAVIEPNRKWFTNTRVISQDTLQSFREAMAEKQKDPYTVLLKSNKLPMSLIRDGPKLEDGLKKHQAKMTIEREPFSETFGPKAQRKRPKLSFNTVDELAGYSEQSLDSYHARLEEKKLLSGAAGAAALESEAPVEEDFSVATAKEAIFNKGTSKRIWNELYKVIDSSDVILHVLDARDPLGTRCRHVEKYLAAEAPHKHLVFVLNKIDLVPSSQAAAWIRILQKDHPTCAMRASITNPFGRGSLIDLLRQFSVLHKDRKQISVGLIGYPNVGKSSIINALRGKAVAKVAPIPGETKVWQYVTLMKRIYLIDCPGIVPPNQHDTPEDLLLRGVVRVENVEHPEQYIPAVLRKVKQHHMERTYELRGWKDHIEFLEMLARKSGRLLKGGEPDVDGVAKQVLNDFMRGKIPWFTPAPEPEKGDEPVIEGRAGRLGEMPKKRKREETESVADTSMADSTAAAEPEDESEDEGSDSESEFSGFSSDSDSEVEVEVGKEAQDDSAPDMIPLDETSDEDEYNEEDDDGEEDGSEDGDEMSDNDIEDASDIESESESEPSPPKRRKKAR
Protein: Receptor expression-enhancing protein (A0A0B4KEX8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU362006}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362006}.
Interaction partners:
Sequence:
MRPIYQQEPPLFYQRPANLRRLRHPPGTVYGRSYSLEDQPEDVIPVYPKFIYAPQQQQQQQRAPYPLYQLGDSLSSLDSDFPENEYAGAYIVEDRVPLANAPTPKVVQNLNALGRMLELLQRCPLPCLSFNTACICSLIVIFLAPRTCAQSLLFPAFRLFCGTLYPAYASYKAVRTKDVKEYVKWMMYWIVFAFFTCIETFTDIFISWLPFYYEVKVALVFWLLSPATKGSSTLYRKFVHPMLTRHEQEIDEYVNQAKERGYSAVLQLGSKGVNYATNVLMQTAIKRRCIK
Protein: Neuronal calcium sensor 1 (NCS-1) (P36608)
Organism: Caenorhabditis elegans
Function: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Can substitute for calmodulin and directly activate PDE, NO synthase, and calcineurin. Regulates associative learning and memory in a calcium dependent manner.
Subcellular location: Membrane {ECO:0000250|UniProtKB:P62166, ECO:0000250|UniProtKB:P62168}; Lipid-anchor {ECO:0000250|UniProtKB:P62166}.
Interaction partners:
- Phosphatidylinositol 4-kinase beta
- Serine/threonine-protein phosphatase 2B catalytic subunit
- NMDA-type ionotropic glutamate receptor NMR-2
- LITAF domain-containing protein
Sequence:
MGKGNSKLKSSQIRDLAEQTYFTEKEIKQWYKGFVRDCPNGMLTEAGFQKIYKQFFPQGDPSDFASFVFKVFDENKDGAIEFHEFIRALSITSRGNLDEKLHWAFKLYDLDQDGFITRNEMLSIVDSIYKMVGSSVQLPEEENTPEKRVDRIFRMMDKNNDAQLTLEEFKEGAKADPSIVHALSLYEGLSS
Protein: Combgap (Q9NI49)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCAAQNPPPFGYTWGFADNGNRAAESVLEISPNINYTVSGESMPYLLSTDGSLAVQKDVKGLTAGGKNNVVRRMFVVNDPSFPPGTQRVITAGGASTVVKKQDNNQQVLSLDKNCDILPGISVQVQKVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTFKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQDGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVCECGKASSRRTT
Protein: UPF3 domain-containing protein (Q9CTQ4)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRSEEGAGGLGAALAARGPSWREKLSSSETHCRRESPRKESAAPPAPTLSESGAGKPREEKRTALSKVVLRRLPPGLTKEQLEEQLRPLPAHDYFEVVAADLSLYPHVYSRAYINFRNPDDILLFRDRFDGYIFIGNKGLEYPAVVEFAPFQKIA
Protein: Photosystem II reaction center protein L (PSII-L) (Q2LIN3)
Organism: Oryza sp. IRGC 105360
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01317}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01317}.
Interaction partners:
Sequence:
MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
Protein: Small ribosomal subunit protein mS35 (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt) (P82673)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25838379}.
Interaction partners:
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein mS39
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein mS25
Sequence:
MAAAALPAWLSLQSRARTLRAFSTAVYSATPVPTPSLPERTPGNERPPRRKALPPRTEKMAVDQDWPSVYPVAAPFKPSAVPLPVRMGYPVKKGVPMAKEGNLELLKIPNFLHLTPVAIKKHCEALKDFCTEWPAALDSDEKCEKHFPIEIDSTDYVSSGPSVRNPRARVVVLRVKLSSLNLDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEELLGTKEIEEYKKSVVSLKNEEENENSISQYKESVKRLLNVT
Protein: Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) (O35276)
Organism: Rattus norvegicus (Rat)
Function: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
Subcellular location: Membrane {ECO:0000250|UniProtKB:O60462}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60462}.
Interaction partners:
- Semaphorin 3F
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor C
- Plexin-A1
- Plexin-A3
- Semaphorin-3C
- Vascular endothelial growth factor receptor 3
- Semaphorin-3A
- Semaphorin-3B
- Vascular endothelial growth factor receptor 2
Sequence:
MDMFPLTWIFLALYFSGHKVRSQQDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWVVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSVLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPRMEIILQFLTFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSKLRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPPENFQCNAPLGMESGRIANEQISASSTFSDGRWTPQQSRLHGDDNGWTPNVDSNKEYLQVDLRFLTMLTAIATQGAISRETQKGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQANNDATELVLNKLHTPLLTRFIRIRPQTWHLGIALRLELFGCRVTDAPCSNMLGMLSGLIADTQISASSTREYLWSPSAARLVSSRSGWFPRNPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAMEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFEPVPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPMDEDATECGENCSFEDDKDLQLPSGFNCNFDFPEETCGWMYDRAKWLQSTWISSANPNDRTFPDDKNFLKLQSDGGREGQFGRLISPPVHLPRSPVCMEFQYQAMGGHGVALQVVREARQESKLLWVIREDQGSEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEISIDDIRISTDVPLENCMEPISAFAVDIPEIHGGEGYEDEIDDDYEGDWNNSSSTSGAGSPSSGKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKINHQKCCSEA
Protein: Interferon gamma (Q2PPE0)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
ESDKKIIQSQIVSFYFKLFENLKDNQVIQRSMDIIKQDMFQKFLNGSSEKLEDFKRLIQIP
Protein: Stathmin (Q5RIC7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Gnb2 protein, beta polypeptide 2)/G
- Tubulin tyrosine ligase.
Sequence:
MTLAAYRDKVKELPLVSLLCSCINSNRAENPTYKAEDAVDLNWCVIKEMEVIELNKRTSGQAFEVILKPPSFDVAPELNTSMPQRKDPSLEEIQKKLEAAEERRKFQEAEMLKHLAEKREHEREVIQKAFEENNNFIKNAKEKLEQRMEANKENREALLAAMLERLQEKDKHAEEVRKNKELKEEACR
Protein: C-phycocyanin alpha subunit (Q54715)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex (phycobilisome, PBS). Phycocyanin is the major phycobiliprotein in the PBS rod.
Subcellular location: Cellular thylakoid membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Part of the phycobilisome rod. {ECO:0000250, ECO:0000269|PubMed:31015331}.
Interaction partners:
- Photosystem I-associated linker protein CpcL
- Allophycocyanin alpha chain
- Phycobilisome 32.1 kDa linker polypeptide, phycocyanin-associated, rod 1
- C-phycocyanin beta subunit
- Phycobilisome 8.9 kDa linker polypeptide, phycocyanin-associated, rod
- Phycobilisome rod-core linker polypeptide CpcG
- Phycobilisome 32.1 kDa linker polypeptide, phycocyanin-associated, rod 2
- Phycocyanin alpha phycocyanobilin lyase CpcF
- Phycocyanobilin lyase subunit alpha
- Phycobiliprotein ApcE
Sequence:
MKTPLTEAVSTADSQGRFLSSTELQIAFGRLRQANAGLQAAKALTDNAQSLVNGAAQAVYNKFPYTTQTQGNNFAADQRGKDKCARDIGYYLRIVTYCLVAGGTGPLDEYLIAGIDEINRTFDLSPSWYVEALKYIKANHGLSGDARDEANSYLDYAINALS
Protein: Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) (P11086)
Organism: Homo sapiens (Human)
Function: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor. Other substrates include phenylethanolamine and octopamine. Also methylates normetanephrine (By similarity).
Interaction partners:
- Dopamine beta-hydroxylase
- Catechol O-methyltransferase
- Transmembrane O-methyltransferase
- Amine oxidase [flavin-containing] B
- Amine oxidase [flavin-containing] A
- Tyrosine 3-monooxygenase
- Aromatic-L-amino-acid decarboxylase
- Corticoliberin
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
Protein: FHA domain-containing protein FHA2 (Protein FORKHEAD-ASSOCIATED DOMAIN 2) (AtFHA2) (Q9SFV2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in the control of plant organ development and specifically in the regulation of stamen development. Does not show transactivation activity in yeast.
Subcellular location: Nucleus {ECO:0000269|PubMed:23192389, ECO:0000269|Ref.4}. Note=Detected at discrete loci in the nucleus. {ECO:0000269|PubMed:23192389}.
Interaction partners:
- Homeobox-DDT domain protein RLT2
- Homeobox-DDT domain protein RLT1
- FHA domain-containing protein At4g14490
- DEAD-box ATP-dependent RNA helicase 27
- Transcriptional repressor ILP1
- Small RNA degrading nuclease 1
- WD-40 repeat-containing protein MSI3
- Zinc-finger domain of monoamine-oxidase A repressor R1 protein
- DDT domain-containing protein DDR4
- Transcription factor bHLH140
Sequence:
MATAVGGGSDVEVGFAKLQGEDFEYYMQSYSIILGRNSKKATVDVDLSSLGGGMNISRNHARIFYDFTRRRFSLEVLGKNGCLVEGVLHLPGNPNVKLDSQDLLQIGDKEFYFLLPVRSILGGPLGPRHHVSGQTSVVPYHNYQSGPGSGSGKKGVRSRELYEYDDEDDDDDDDEEDDMRGSGKKTRRDGHEVVYASGEKKREGRSKVDREADDQQFLQLEEKDVVSSVATVLSDLCGPGEWMPMEKLHSVILKEYGNVWHHSRVRRYLSQEDWAIPEAKGKPWYGLLMLLRKYPEHFVINTRSKGRVTLEFVSLVTLLS
Protein: Alanine dehydrogenase (EC 1.4.1.1) (P17557)
Organism: Geobacillus stearothermophilus (Bacillus stearothermophilus)
Function: Catalyzes the reversible reductive amination of pyruvate to L-alanine (Probable). A key factor in the assimilation of L-alanine as an energy source via the tricarboxylic acid cycle during sporulation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A0QVQ8}.
Interaction partners:
Sequence:
MKIGIPKEIKNNENRVAITPAGVMTLVKAGHEVYVETEGGAGSGFSDSEYEKAGAADRCRTWRDAWTAEMVLKVKEPLAREFRYFRPGLILFTYLHLAAAERVTKAVVEQKVVGIAYETVQLANGSLPLLTPMSEVAGRMSVQVGAQFLEKPHGGKGILLGGVPGVRRGKVTIIGGGTAGTNAAKIGVGLGADVTILDINAERLRELDDLFGDHVTTLMSNSYHIAECVRESDLVVGAVLIPGAKAKLVTEEMVRSMTPGSVLVDIAIDQGGIFETTDRVTTHDDPTYVKHGVVHYAVANMPGAVPRTSTFALTNVTIPYALQIANKGYRAGCLDNPALLKGINTLDGHIVYEAVAAAHNMPYTDVHSLLHG
Protein: CCAAT/enhancer-binding protein epsilon (C/EBP epsilon) (Q15744)
Organism: Homo sapiens (Human)
Function: Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:11313242, ECO:0000269|PubMed:26019275}.
Interaction partners:
- AT-rich interactive domain-containing protein 5B
- CCAAT/enhancer-binding protein alpha
- Transcription factor PU.1
- Lactotransferrin
- Retinoic acid receptor alpha
- Erythroid transcription factor
- Centromere protein V
- Retinoic acid receptor RXR-alpha
- Myeloperoxidase
- Granzyme H
Sequence:
MSHGTYYECEPRGGQQPLEFSGGRAGPGELGDMCEHEASIDLSAYIESGEEQLLSDLFAVKPAPEARGLKGPGTPAFPHYLPPDPRPFAYPPHTFGPDRKALGPGIYSSPGSYDPRAVAVKEEPRGPEGSRAASRGSYNPLQYQVAHCGQTAMHLPPTLAAPGQPLRVLKAPLATAAPPCSPLLKAPSPAGPLHKGKKAVNKDSLEYRLRRERNNIAVRKSRDKAKRRILETQQKVLEYMAENERLRSRVEQLTQELDTLRNLFRQIPEAANLIKGVGGCS
Protein: ATP synthase peripheral stalk subunit b, mitochondrial (ATP synthase F(0) complex subunit B1, mitochondrial) (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase subunit b) (ATPase subunit b) (P19511)
Organism: Rattus norvegicus (Rat)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular location: Mitochondrion. Mitochondrion inner membrane.
Interaction partners:
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase F
- ATP synthase F
Sequence:
MLSRVVLSAAATAAPCLKNAAVLGPGVLQATRVFHTGQPRLAPLPPLPEYGGKVRLGLIPEEFFQFLYPKTGVTGPYVLGTGLSLYFLSKEIYVITPETFSTISVVGLIVYVIKKYGASIGEFIDKLNEEKIAQLEEIKQSSMKQIQDAINREKAQQALVQKRHYLFDVQRNNIALALEVTYRERLHKAYKEVKNRLDYHISVQDMMRRKEGEHMINWVEKHVIQSISAQQEKETIAKCIGDLKMLAKKAQAQPIM
Protein: M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string) (P20483)
Organism: Drosophila melanogaster (Fruit fly)
Function: This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate Cdk1 and activate the Cdk1 activity.
Interaction partners:
- G1/S-specific cyclin-E
- Serine/threonine-protein kinase polo
- Serine/threonine-protein kinase grp
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-B
- Ovarian-specific serine/threonine-protein kinase Lok
- G2/mitotic-specific cyclin-A
- Wee1-like protein kinase
- Cyclin-dependent kinase 2
- Origin recognition complex subunit 2
Sequence:
MLWETIVEENNCSMDCNISNNTSSSSSINKMSGSRRARRSLELMSMDQEELSFYDDDVVPQDQQRSASPELMGLLSPEGSPQRFQIVRQPKILPAMGVSSDHTPARSFRIFNSLSSTCSMESSMDDEYMELFEMESQSQQTALGFPSGLNSLISGQIKEQPAAKSPAGLSMRRPSVRRCLSMTESNTNSTTTPPPKTPETARDCFKRPEPPASANCSPIQSKRHRCAAVEKENCPAPSPLSQVTISHPPPLRKCMSLNDAEIMSALARSENRNEPELIGDFSKAYALPLMEGRHRDLKSISSETVARLLKGEFSDKVASYRIIDCRYPYEFEGGHIEGAKNLYTTEQILDEFLTVQQTELQQQQNAESGHKRNIIIFHCEFSSERGPKMSRFLRNLDRERNTNAYPALHYPEIYLLHNGYKEFFESHVELCEPHAYRTMLDPAYNEAYRHFRAKSKSWNGDGLGGATGRLKKSRSRLML
Protein: CD44 antigen (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (Phagocytic glycoprotein I) (F1SGT4)
Organism: Sus scrofa (Pig)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Osteopontin
- Matrix metalloproteinase-9
- Ezrin
- E-selectin
- Moesin
- CD34 molecule
- Radixin
- CD19 molecule.
- Integrin beta-1
- Intercellular adhesion molecule 1
Sequence:
MSPAHSLRRSDAMDTFWWRAAWGLCLVQLSLAQIDLNITCRYAGVFHVEKNGRYSISKTEAADLCKAFNSTLPTMAQMEAALNIGFETCRYGFIDGHVVIPRIHPNAICAANNTGVYILASNTSQYDTYCFNASAPPEEDCTSVTDLPNTFEGPITITIVNRDGTRYTKKGEYRTNPEDINPNMAPEDDMSSGSSSERSTSGGYSIFHTHLPTTTHPDQEGPWVSSNPEDTPATITSAVPSNSHTAAHMPYGRTANNWMWSWFGNSQSKTQDQTTTATTALVSTSGTTSKTATKRHETQDWFSWWFQPSESKNHLHTTTVMAGTDSNIISAGWEPTEDNEDERDKHPSYSGSGIDDDEDFISSTISTTPGVFNHLQQNEDWTQQSPGHLDPEVSLQTTTRMTDMDRSGTSAHGENWTWDPHSSLSHHENHDEEETQHPTSTTQAIPSSTTEETATQKEQWFENGWSGGYPHTPKEDPHATAGTTAASAHDSHPSERATTQSQVDSSWTHFFDPVSHPMGRGHQTEERMEQSDTQSSSTSHGGLEEDKDHPVAATPTSSNRNDGRSGRRGGSLPEDSATSVEGYTLHSPDTNEYRTLILVTPTKTGSPGVTEVTIVGDSTSNVDLSSSEDQDPYFDPSGRSFTTHGSESAGHSSGSQEGEANTTSGPIRKSQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINNGNGPVEERKPSGLNGEASKSQEMVHLVNKESTETPDQFMTADETRNLQNVDMKIGV