wanglab/gogpt-training-data huggingface dataset:
Protein: Cell division control protein 45 homolog (Q9YHZ6)
Organism: Xenopus laevis (African clawed frog)
Function: Required for initiation of chromosomal DNA replication. Binds to chromatin in a mutually dependent manner with the GINS DNA replication complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:9755170}. Chromosome {ECO:0000269|PubMed:9755170}. Note=Associates with chromatin. {ECO:0000269|PubMed:9755170}.
Interaction partners:
Sequence:
MFVSDLRKEFFDVIVTERVLLLVAPDVDALCACKILQALFQCDHVQYTLVPVSGWQELETLFLEHKEQFRYFVLINCGANIDLLETLQPQEEAIFYICDTHRPIDVVNIYNDSQVKLLIRQDDDLEIPAYDDIFNDDEEDGEDSGNESDGAEPSGKRRRFDEAAVERRIERRRQRREWEARRREIIFDYEQYEYHGTSSAMMMFELAWIMSKDSNDMLWWAIVGLTDQWVQDRITQMKYVTDVGTLQRHVSRHNHRNEDEENSLSIDCMRIAFEYDLRLSLYQHWSLYESICNSCYTSATLKLWSLQGQKKLQEFLADMGMPLKQVKQKFNSMDISLKENLREMLEESANKFGMKDVRVQTFSVQFGFKNKFLASDIVFAVLSLLENTERDEKGTDNFIKALDSLSRSNLDKLHTGLEMGKKLLCAIQQTVASCICTNLILSQGPFLYCYLMEGTPDVKMFSNPISLCLLCKYLLKSFVCSTKNKRCKLLPLVLAAPLDAEKGTVIMVGIPPEAESSDKKNFFGRAFEKAAESTSSRTLHNHFDMSIIELRTEDRSKFLDALISLLS
Protein: Transmembrane protein 160 (Q9NX00)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:34936870}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGGGWWWARAARLARLRFRRSLLPPQRPRSGGARGSFAPGHGPRAGASPPPVSELDRADAWLLRKAHETAFLSWFRNGLLASGIGVISFMQSDMGREAAYGFFLLGGLCVVWGSASYAVGLAALRGPMQLTLGGAAVGAGAVLAASLLWACAVGLYMGQLELDVELVPEDDGTASAEGPDEAGRPPPE
Protein: Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) (Q9BVS4)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. {ECO:0000269|PubMed:19564402}.
Interaction partners:
- Pre-rRNA-processing protein TSR1 homolog
- Protein LTV1 homolog
- RNA-binding protein NOB1
- Small ribosomal subunit protein uS5
- Bystin
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS3
- RNA-binding protein PNO1
- KRR1 small subunit processome component homolog
Sequence:
MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVSASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEKNRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTRTLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNIKSSLEAASFWGE
Protein: Suppressor of RNA silencing (Gamma-B protein) (Gammab protein) (Q80874)
Organism: Barley stripe mosaic virus (BSMV)
Function: Suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Promotes viral cell-to-cell long distance movement by enhancing the ATPase activity of TGB1. Enhances RNA helicase activity of replication protein alpha-A. Suppresses autophagy induced by the host as a defense mechanism against viral infection.
Subcellular location: Host chloroplast envelope {ECO:0000269|PubMed:28388677}. Host endoplasmic reticulum {ECO:0000269|PubMed:32730331}. Host cell junction, host plasmodesma {ECO:0000269|PubMed:32730331}. Note=Recruited by the replication protein alpha-A to viral replication sites at the host chloroplast membrane. {ECO:0000269|PubMed:28388677}.
Interaction partners:
Sequence:
MMATFSCVCCGTSTTSTYCGKRCERKHVYSETRNKRLELYKKYLLEPQKCALNGIVGHSCGMPCSIAEEACDQLPIVSRFCGQKHADLYDSLLKRSEQELLLEFLQKKMQELKLSHIVKMAKLESEVNAIRKSVASSFEDSVGCDDSSSVSKL
Protein: Transmembrane protein (Q9SN29)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein transport Sec1a
- Putative E3 ubiquitin-protein ligase XBAT34
- Diaminopimelate epimerase, chloroplastic
Sequence:
MGLSKGRLKAWFNKKITDPLLQILRRGTEPKQLAFSAALGITLGIFPICGVPVLLCGVAFALLGSSCHAPTVMLANIIATPVELALVVPFLRLGEKVTGGPHFPLTSDALKKVFTGQASQEVFLSIGNALLGWLVATPFFFITLYVVLLPCFTILVRKFGGVASTQKLPTSMETELNPKPRDA
Protein: T-cell surface antigen CD2 (LFA-2) (LFA-3 receptor) (Lymphocyte antigen 37) (Ly-37) (T-cell surface antigen T11/Leu-5) (CD antigen CD2) (P08920)
Organism: Mus musculus (Mouse)
Function: CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Subcellular location: Cell membrane {ECO:0000269|PubMed:2440689}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Intercellular adhesion molecule 1
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface glycoprotein CD8 alpha chain
- T-cell surface glycoprotein CD3 delta chain
- CD2 antigen cytoplasmic tail-binding protein 2
- T-cell surface glycoprotein CD3 zeta chain
- CD2-associated protein
- CD48 antigen
- T-cell surface glycoprotein CD3 gamma chain
- T-cell surface glycoprotein CD4
Sequence:
MKCKFLGSFFLLFSLSGKGADCRDNETIWGVLGHGITLNIPNFQMTDDIDEVRWVRRGTLVAEFKRKKPPFLISETYEVLANGSLKIKKPMMRNDSGTYNVMVYGTNGMTRLEKDLDVRILERVSKPMIHWECPNTTLTCAVLQGTDFELKLYQGETLLNSLPQKNMSYQWTNLNAPFKCEAINPVSKESKMEVVNCPEKGLSFYVTVGVGAGGLLLVLLVALFIFCICKRRKRNRRRKDEELEIKASRTSTVERGPKPHSTPAAAAQNSVALQAPPPPGHHLQTPGHRPLPPGHRTREHQQKKRPPPSGTQIHQQKGPPLPRPRVQPKPPCGSGDGVSLPPPN
Protein: Uncharacterized protein (Q57TX0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Adrenodoxin reductase, putative
- NB-ARC domain-containing protein
- NADH-ubiquinone oxidoreductase complex I subunit
- NADH dehydrogenase subunit NI8M
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- Peptidyl-prolyl cis-trans isomerase
Sequence:
MSSGGNVGVGVAKTIKTKVKSNLGDILPARFYNMMWTYRLGQLTTSNVRRLKDASIPFDYGGSNNDSDNKSGGGGENNNNDGANSPVKSDLQPHAVHKFDRDRDDKWSLLIAIPKNSDHFRNIVDCPRGSFMFGHTDPQLFHWFKQLGTLPPRAIVSGRFEVLSGDLLQEAWERTFVRHPVIHSIAQEMWNRKESKTEEEIVTIERREREEDEKRMRRMSSSDWRAKFRERERNPTPEEDEERPVYVIKPDAFAVLRLKPDVQLWMDCTSQTHRVWEPLIAEPDPLCRCSPRFVRMLNLARQKLVPSLNMNYSLKLANAFVFEIDQKGLWAMGTQESLDAGNADGGGENNTRREEWTELRLEFGNKQVINTEQELEWWVRGLTKLGAPEMSQSNSSIEDAGMNPEDYDYRHI
Protein: Histone transcription regulator 3 homolog (P87315)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Required for transcriptional silencing in the outer repeat (otr) region of centromeric repeats and the Tf2 long terminal repeat retrotransposons.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Histone transcription regulator slm9
- Histone promoter control protein 2
- Protein hir1
- Histone chaperone cia1
- UPF0656 protein C926.02
Sequence:
MATFTPLNAASEDLDKEKRTLEIRIEEAVQIYQNALSAQKQGDDNAATKYYDELLNVRILRELPFTVNSNYKKNNALLLLHYLTRKNHGLFLLSKLQSLLSLDPSTDPIPVYRDALLDFAIALACDYNDIELWSFVAELAEKLEMPRIQRFALESSFYTGYEPFDAERVFTNIDDLNPGKLISLQNLYNLLKKLGGIAEPLPQLDLSISSLYTLPSFFPQLPTPSFHRRSINLCPKIKKLQLSHDTLHGFLDLVLYALQINEKKTPTRGFPSTLIIHVHSLNLSTAESHDLESTDSELWSEISDAGPDTNTINTAAKLSEPVYAKDIVPPPSDNLPKPQLLKRPIDDSDVRISKRSRGRDLRTPSESNLFSLIASITSDINEQIQKRFPDATSPFSGESMFREYSSIFEDYHQLLVNFPSEGSIPDLDVSTDSAANGAFSKMILIDLAMHSANRLEHMQVPDGYLLQLLSEVNSLNMVPAELATFFVESMLRPRKLEPPFYLQQCWGKIFKKKFTTICERIESTLHELVKASLQTPEVFNISQSLFELFLDDYFLALKFSSNDQKDDNVSEIPTESLEYKKLRCLRWKSLTEQVVELQPSCKSSSQRHLIIRNSWARNLLLRLTGCSSEAIVENFKQLRCLLQENSDSLELLNSQCMADLSVQVVDFELSKLQTVEFFNTLFMNTKNLDFNAVIKNLEPVLSPENKFAEDPQAKFISQFLEKTSTEFQIHLWYLLYQAYSSAHRPYNSLLCAFQSLKIILIRLCSSSFSIQDAGRRQAELLGMLNFSSNLFRIIWQKLHEQPDILSPCNEMTVIDCIRIILIYLRTFAIYVGIDEDISDQRIPKPSNPEFDSYAQTVKDSLMSGWCIFYTLFAHLLHYDFIKADAQKLLPQILTAIHSQYSFRGYCSSSNQSFLELSQTECQRLDAWENENEILQCVCCRFNLIIGSEYYVPQSHQSDSVNLTSNDAIKIIPFILGFAVKRSHGWVMPRSDQKNALEIICKVIRFPGENNADVYFNKCAIKEFLERDISPQLTKMLLKSNDILGLREIGSKVVDDRVRGLYYAQSQVLFGYYRSRLKGSRCINDLLVIIKYFLLDLYLNPRRQDSWYTCSSVFSSLADEELGWSAEQICLADDVINEYRRKAILCNLMALSLPFTQDKLFKANVYFDFAMNLYASARPPLEMAAFLPSETRVFSGASGLYNLSMKPIEVSKVIALAADYFGMSAELSNDWRALYMLGKACRKCGDMENALVHFEAAAALAPTKSGSGSQQALLIEPHYALLSNLSKAAIEGSVEIVQILSYLRRIRHPPKDSGSLLEVKNEDVNIYKRNALLFILKALAEMRILDKQSWHHRPTYRIAKIMEHLGNVQQAKEEMETLFSYKTSGKSLLNIWRTPNERPGRHFYYGATYSRYLLSLFYKTNDKVNFLQFLKRFRRSSSTIYEHRQIWLDIMIKYLEDLRLQHSVKETQINDLPLVEFKYVYKEISLLDEQKLSLLHQVYEIRKLNNGLYPTIKVDDFLIDCFMSLYNEVKSSISPLDANIPNSPSTITAKPLNDEKAINNENSVKQKTVITRKDVVSKVLALFRPHRETYYRETQNKILQKLASTSSSLVRSFTEDSSQAGESPGIHEEIQ
Protein: Derlin (B4E1G1)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363059}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363059}.
Interaction partners:
Sequence:
MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ
Protein: Major urinary protein 18 (Major urinary protein 4 like 4) (A0A8I6AMI2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKLLLLLLCLGLTLVCGHAEEANSKRGNLDVDKLNGDWFSIVVASNKREKIEENGSMRVFMQHIDVLENSLGFKFRIKENGECRELYLVAYKTPEDGEYFVEYDGGNTFTILKTDYDRYVMFHLVNFKNGETFQLMELYGRTKDLSSDIKEKFAKLCVAHGITRDNIIDLTKTDRCLQARG
Protein: G2/mitotic-specific cyclin-B1 (Q9IB44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MMALRVTRNTRLASSENQNALPGKAVVANKPGLRPRAALGEIGNNPQTRQALKKKEVKVAPAAEVVVEKAPVVQQPKKDSPKVQHGVKVVSEPSSPVPMETSGCASDDLCQAFSDVLLNIKDVDADDYDNPMLCSEYVKDIYLYLRQLETEQAVRPKYLAGKEVTGNMRAILIDWLVQVQIKFRLLQETMYMTVAIIDRFLQDHPVPKKQLQLVGVTAMFIASKYEEMYPPEIADFAFVTDRAYTTSQIREMEMKVLRVLNFGFGRPLPLQFLRRASKIGDVTAEHHTLAKYFLELTMVDYDMVHYPPSQMASAAYALTLKVFNCGDWTPTLQHYMGYTEDELVPVMQHIAKNVVRVNEGLSKHLAVKNKYSSQKQMRIATISQLKSSLIKDLAKQIS
Protein: Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Q95RB1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Pre-mRNA-splicing factor syf1 homolog
- Protein BUD31 homolog
- Protein crooked neck
- Puff-specific protein Bx42
- Pleiotropic regulator 1
- 116 kDa U5 small nuclear ribonucleoprotein component
- Cell division cycle 5, isoform A
- Pre-mRNA-processing factor 17
- Pre-mRNA-processing factor 19
- RNA helicase aquarius
Sequence:
MSMSKTTNTYNRQNWEDAEFPILCQTCLGDNPYVRMIKERFGKECKICTRPFTIFRWCPGARMRFKKTEICQTCARLKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDGTEAAGAVGRSLAANEMLSKLARTAPYYKRNRPHICSFWVKGECKRGEECPYRHDKPNEPDDPLCEQNIKDRYYGRNDPVAEKIMKRAASLPTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRSIALVPRQQCAFVQYTKRNAAELAAERTFNKLVIQGRKVSIKWAHSQAKQGTAAKTDRRFDLAGIPPPSAKPNDYFNLRQEQINVMPAGMKLHQLPSNLVPASAYQMYGQPTYAAPYGNATSTALSSSGVNLDSISIPPPPGQVPYPSQDASRMGAVKK
Protein: 26S proteasome regulatory subunit 7 homolog (O42931)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- 26S proteasome regulatory subunit 6B homolog
- Probable proteasome subunit alpha type-5
- 26S proteasome regulatory subunit rpn12
- Probable 26S proteasome regulatory subunit rpn6
- 26S proteasome regulatory subunit rpn10
- 26S proteasome regulatory subunit rpn1
- 26S proteasome regulatory subunit rpn2
- Probable 26S proteasome regulatory subunit rpn9
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit rpn7
Sequence:
MPPKEDWEKYQKPVDTEEENDKNPPPLDEGDIELLKSYATGPYARELAAIKEDTEAVLKRINDTVGIKESDTGLAPISFWDVAADRQRMSEEQPLQVARCTKIIENEQSAEKNAYVINLKQIAKFVVSLGERVSPTDIEEGMRVGCDRNKYAIQLPLPPKIDPSVTMMQVEEKPDVTYGDVGGCKEQIERLREVVELPLLSPERFVKLGIDPPKGIMLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAIGGARFDDGAGGDNEVQRTMLELITQLDGFDPRGNIKVLFATNRPNTLDEALMRPGRIDRKVEFGLPDLEGRAHILRIHAKSMAIDKDIRWELIARLCPSQTGAELRSVCTEAGMFAIRARRRVATEKDFLDAVQKVVKGNQKFSSTADYMNMSS
Protein: Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) (Q96CC6)
Organism: Homo sapiens (Human)
Function: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18832597}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized in the endoplasmic reticulum membrane (PubMed:15965977). {ECO:0000269|PubMed:15965977}.
Interaction partners:
- Disintegrin and metalloproteinase domain-containing protein 17
- Protransforming growth factor alpha
Sequence:
MSEARRDSTSSLQRKKPPWLKLDIPSAVPLTAEEPSFLQPLRRQAFLRSVSMPAETAHISSPHHELRRPVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQRRSFTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQADLTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH
Protein: Isotocin (Oxytocin-neurophysin 1 precursor) (Q8UUT8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSGGLLSAAALLCLLSVCSACYISNCPIGGKRSVQDWPIRQCMPCGPGDRGRCFGPSICCGEGIGCLVGSPETLRCLEEDFLPSPCEMSGKACGYEGRCAAPGVCCDSEGCSVDQSCVDGDADAAAVNQPANSPDLLLKLLHLSSHTHPSRIHQ
Protein: Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) (P57737)
Organism: Homo sapiens (Human)
Function: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
Subcellular location: Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM16
- Epidermal growth factor receptor substrate 15
- Kelch-like protein 20
Sequence:
MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPGVLGIVPLQGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPLPDTAQPAVMETPVGDADASEGFSSPPSSLTSPSTPSSLGPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAMVAKLGNREDPLPQDSFEGVDEDEWD
Protein: Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldo-keto reductase family 1 member B3) (Aldose reductase) (AR) (P45376)
Organism: Mus musculus (Mouse)
Function: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Sorbitol dehydrogenase
- Sepiapterin reductase
- Dihydrofolate reductase
- Dihydropteridine reductase
- Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- L-xylulose reductase
- Galactose mutarotase
- glycerol kinase
- Tyrosine 3-monooxygenase
- Glycerol kinase 2
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
Protein: Receptor associated protein of the synapse (E9PJP9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGQDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVGNKLSQLKLHCLSESIYRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV
Protein: 3,5-dihydroxybiphenyl synthase (EC 2.3.1.177) (Biphenyl synthase 1) (SaBIS1) (Q27Z07)
Organism: Sorbus aucuparia (European mountain ash) (Rowan)
Function: Type III polyketide synthase involved in the biosynthesis of the phytoalexins bisphenyls and dibenzofurans. Can also use salicoyl-CoA and malonyl-CoA to produce a diketide intermediate yielding 4-hydroxycoumarine after cyclization and enolization. Can also use m-hydroxybenzoyl-CoA as substrate, producing m-hydroxybenzoyl diacetic acid lactone as a derailment product. No activity with p-hydroxybenzoyl-CoA, CoA-linked cinnamic acids or acetyl-CoA.
Interaction partners:
Sequence:
MAPLVKNHGEPQHAKILAIGTANPPNVYYQKDYPDFLFRVTKNEHRTDLREKFDRICEKSRTRKRYLHLTEEILKANPSIYTYGAPSLDVRQDMLNSEVPKLGQQAALKAIKEWGQPISKITHLIFCTASCVDMPGADFQLVKLLGLNPSVTRTMIYEAGCYAGATVLRLAKDFAENNEGARVLVVCAEITTVFFHGLTDTHLDILVGQALFADGASAVIVGANPEPKIERPLFEIVACRQTIIPNSEHGVVANIREMGFTYYLSGEVPKFVGGNVVDFLTKTFEKVDGKNKDWNSLFFSVHPGGPAIVDQVEEQLGLKEGKLRATRHVLSEYGNMGAPSVHFILDDMRKKSIEEGKSTTGEGLEWGVVIGIGPGLTVETAVLRSESIPC
Protein: Ceramide synthase (EC 2.3.1.-) (Protein FAM57B) (TLC domain-containing protein 3B) (Q7TNV1)
Organism: Mus musculus (Mouse)
Function: Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis.
Subcellular location: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:23275342}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23275342}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23275342}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Serine palmitoyltransferase 2
- Serine palmitoyltransferase 1
- Serine palmitoyltransferase 3
- Sphingomyelin phosphodiesterase
- Sphingosine kinase 2
- Ceramide synthase 2
Sequence:
MLTPMVAGGVVFPGLFLLSKNTLQRLPQLRWEEADAVIVSARLVSSVQAIMASTAGYIVSTSCKHIIDDQHWLSSAYTQFAVPYFIYDIYAMFLCHWHKHQVKGHGGEDGTPRALGSTWAVVRGYLHKEFLMVLHHAAMVLVCFPLSVVWRQGKGDFFLGCMLMAEVSTPFVCLGKILIQYKQQHTLLHKVNGALMLLSFLCCRVLLFPYLYWAYGRHAGLPLLSVPMAIPAHVNLGAALLLAPQLYWFFLICRGACRLFRPRGSPPPSPCQTQD
Protein: Hairy-related 4, tandem duplicate 2 (Hairy-related 4, tandem duplicate 5) (B0V3D4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAPTITGSISSRETLLTNKLRKPMVEKIRRERINSSIEKLKTLLAQEFVKQQPDSRQEKADILEMTLDFLRRSQKSSAAGDGRSRCVQEAVSFLSQCPVQTQSHTRLMKLFLHMQTPADQHTRVDNPQTTETHANSSAKQHTPAHSHIWRPW
Protein: Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53) (Q84940)
Organism: Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A (strain Ohio State University))
Function: Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities. Recognizes the host NF-kappa-B regulator BTRC through the presence of a DSGXS motif in the C-terminal substrate recognition domain.
Subcellular location: Host cytoplasm, host cytoskeleton {ECO:0000255|HAMAP-Rule:MF_04088}.
Interaction partners:
Sequence:
MATFKDACYYYKRINKLNHAVLKLGVNDTWRPSPPTKYKGWCLDCCQHTDLTYCRGCTMYHVCQWCSQYGRCFLDNEPHLLRMRTFKNEVTKDDLMNLVDMYDTLFPMNQKIVDKFINNTRQHKCRNECVNQWYNHLLMPITLQSLSIELDGDVYYIFGYYDDMNNVNQTPFSFVNLVDIYDKLLLDDVNFTRMSFLPVTLQQEYALRYFSKSRFISEQRKCVSDSHFSINVLENLHNPSFKMQITRNCSELSSDWNGACKLVKDTSAYFNILKTSHVEFYSISTRCRVFTQRKLKIASKLIKPNYITSNHRTSATEVHNCKWCSINSSYTVWNDFRVKKIYDNIFNFLRALVKSNVNVGHCSSQEKIYECVENILDVCDNEKWKTSVTKIFNYLEPVELNAVNYVLFNHEVNWDVINVLVQSIGKVPQILTLNDVTTIMQSIIYEWFDTKYMRNTPMTTFTVDKLRRLCTGSKTVDYDSGISDVE