wanglab/gogpt-training-data huggingface dataset:
Protein: Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)] (P13504)
Organism: Mus musculus (Mouse)
Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000305}. Secreted {ECO:0000250}.
Interaction partners:
- Interleukin-1 alpha
- Interleukin-1 receptor antagonist protein
- Interleukin-1 beta
- Myeloid differentiation primary response protein MyD88
- Interleukin-1 receptor accessory protein
- TNF receptor-associated factor 6
- Interleukin-1 receptor type 2
- Interleukin-1 receptor-associated kinase 4
- Interleukin-1 receptor-associated kinase 1
- Interleukin-33
Sequence:
MENMKVLLGLICLMVPLLSLEIDVCTEYPNQIVLFLSVNEIDIRKCPLTPNKMHGDTIIWYKNDSKTPISADRDSRIHQQNEHLWFVPAKVEDSGYYYCIVRNSTYCLKTKVTVTVLENDPGLCYSTQATFPQRLHIAGDGSLVCPYVSYFKDENNELPEVQWYKNCKPLLLDNVSFFGVKDKLLVRNVAEEHRGDYICRMSYTFRGKQYPVTRVIQFITIDENKRDRPVILSPRNETIEADPGSMIQLICNVTGQFSDLVYWKWNGSEIEWNDPFLAEDYQFVEHPSTKRKYTLITTLNISEVKSQFYRYPFICVVKNTNIFESAHVQLIYPVPDFKNYLIGGFIILTATIVCCVCIYKVFKVDIVLWYRDSCSGFLPSKASDGKTYDAYILYPKTLGEGSFSDLDTFVFKLLPEVLEGQFGYKLFIYGRDDYVGEDTIEVTNENVKKSRRLIIILVRDMGGFSWLGQSSEEQIAIYNALIQEGIKIVLLELEKIQDYEKMPDSIQFIKQKHGVICWSGDFQERPQSAKTRFWKNLRYQMPAQRRSPLSKHRLLTLDPVRDTKEKLPAATHLPLG
Protein: Ribosomal RNA small subunit methyltransferase G (EC 2.1.1.-) (16S rRNA 7-methylguanosine methyltransferase) (16S rRNA m7G methyltransferase) (Q97QD4)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Specifically methylates the N7 position of a guanine in 16S rRNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00074}.
Interaction partners:
Sequence:
MKPKTFYNLLAEQNLPLSDQQKEQFERYFELLVEWNEKINLTAITDKEEVYLKHFYDSIAPILQGLIPNETIKLLDIGAGAGFPSLPMKILYPELDVTIIDSLNKRINFLQLLAQELDLNGVHFYHGRAEDFAQDKNFRAQYDFVTARAVARMQVLSELTIPYLKVGGKLLALKASNAPEELLEAKNALNLLFSKVEDNLSYALPNRDPRYITVVEKKKETPNKYPRKAGMPNKRPL
Protein: C6orf182 protein (Centrosomal protein 57 like 1) (Chromosome 6 open reading frame 182, isoform CRA_c) (Q6P2R3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKVCI
Protein: GCN5-related N-acetyltransferase 7, chloroplastic (EC 2.3.1.255) (EC 2.3.1.48) (Q94AC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:32633465}.
Interaction partners:
- GCN5-related N-acetyltransferase 10, chloroplastic
- Acyl-CoA N-acyltransferases
- GCN5-related N-acetyltransferase 4, chloroplastic
- GCN5-related N-acetyltransferase 5, chloroplastic
- GCN5-related N-acetyltransferase 8
- GCN5-related N-acetyltransferase 9
- GCN5-related N-acetyltransferase 1, chloroplastic
- GCN5-related N-acetyltransferase 2, chloroplastic
- N-terminal acetyltransferase B complex catalytic subunit NAA20
- N-terminal acetyltransferase A complex catalytic subunit NAA10
Sequence:
MAFLCSSLPSSSSIAIFGDPNTDGSSRSYLSIPSLKLRFRPVAASSHICAPAIDKSTFVISESVSEDELWAAACLRVRTFNELNPSAYNIQDHRRYLAEREFEALKERTSGKREGFTRVACINATLPLSQLSSSFEDLCSACKFSDGIEDRVVVGSLDLNQCRWLPDEIAGTKPEGIGVDFARAYLSNVCVAKELHRNGVGYKLIDKSKRVAGEWGITDMYVHVTVDNEAAKSLYMKSGFEQETAEPAWQARYLNRPQRLLLWLALPTSPIMSM
Protein: Semaphorin-3D (Semaphorin-2) (Semaphorin-Z2) (Sema Z2) (Q9W6G6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play a role in the guidance of several axon pathways.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Neuropilin-1a
- Neuropilin
- Plexin A3
- T-box transcription factor 18.
- Neuropilin
- Neuropilin 1b.
- Plexin D1.
- Plexin-A2
- Transcription factor 21
- Dihydropyrimidinase-related protein 3
Sequence:
MKTAGEPDRRRQRRQVRTGRFSCAWWSTSVMLFFSLPEGNCMKESLPRVKLGYKDLIHSRSVVPFTGSSEGQHFQTVLLDEERSRLLLGAKDHVYLLDPDNINKHPKKLSWPASRDRVEMCILAGKNPLTECANFIRVLHSYNRTHVYACGTGAFHPTCAFLEIKGHKEDRWLLLHSNTMESGRMKCPFDPNQPFASVLTDQYLYAGTASDFLGKDSTFTRSLGPPPHQQYIRTDISEDYWINEGKFISAHPISDTYNPDDDKIYFFFREASRDGSTTDKSVLSRVARICRNDVGGLRSLTNKWTTFLKARLVCSIPGPDGVDTHFDELQDIFLLPSRDEKNPMVYGVFTTTSSIFKGSAVCVYTMEDIRAAFNGPYAHKEGPDHRWVEYEGRIPYPRPGTCPSRTYDPHIKTTKDFPDEVISFIRLHPLMYQSVHPMTGRPIFTRINTEYRLTQIIVDRVAAEDGQYAVMFLGTDMGSVLKVVSITQENWSSEEIILEELQVFKNPSPILNMEVSSKQQQLFVGGSDGLVQVSLHRCQIYGQGCAECCLARDPYCAWDGTQCSRYIPASKRRARRQDIKHGDPSSHCWDTEDVLGRNVEEKVLYGVESNSSFLECVSKSQQALIRWFVLKPGVDHRQEIKPDERVLITDRGLLIRWLQRGDAGSYFCTSQEHRFTRTLLHVSLHILDRGQINAHQPAIRESSENPAVTEPRQRYKDYLRMLSGPARSLDEYCETMWHREKKQKQKGKWKHVQELRKSRNRRHH
Protein: DnaJ homolog subfamily B member 1 (M0QYT3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFAEFFGGRNPFDTFFGQRNGEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQDPPVTHDLRVSLEEIYSGCTKKMKISHKRLNPDGKSIRNEDKILTIEVKKGWKEGT
Protein: Right handed beta helix domain-containing protein (Q552D1)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cell envelope {ECO:0000256|ARBA:ARBA00004196}. Cell outer membrane {ECO:0000256|ARBA:ARBA00004442}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKLKFILFIIFSIYILIEVASTQTYNSTCIWWVKYDADSTVQNGNFSNPFSNLKSAIDKISMINNECDTKNITITRVIYIVASDKDDNEKVYKGSGSNTYITISDIFYRFPILIQAIDEQASYTYNQSSPLLPMASTDRYATFVGSSPNEYIIYFQSALTPIIIRGLQFKNGGFSTDDFRQASVITTSSTIVSFENCLFKDNVGGTSGALFYNSQSSAHIENCIFENNKASAGNGGAIYLPSGTAKLQITNSIFKNNNAINGGGVYCAYQYLTMTSNKFISNTALKSGGGLYTLAVADITSVSWDHLLFDSNKAINGSGLFDNNSANQYYNATFISNEATENGGGSYLLDSRIFMQQSNYQSNKAARGGGIFALDTEPYFKSQLFIRDANFTMNSASENGGAIYCSNATARFNTRNLFEDNSATNSSSSTDYCTSSCVTSPGDCGCPGGCGIESDNDKDPNTDAKIAVAIFIPITAILLGVVGFLLWRTHAKSRGMRTKTAAPYDEIRLSPSSQDNDDQL
Protein: Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25) (Q9BVK6)
Organism: Homo sapiens (Human)
Function: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway.
Interaction partners:
- Transmembrane emp24 domain-containing protein 10
- Transmembrane emp24 domain-containing protein 2
- Transmembrane emp24 domain-containing protein 5
- Transmembrane emp24 domain-containing protein 3
- Transmembrane emp24 domain-containing protein 1
- Transmembrane emp24 domain-containing protein 7
- Surfeit locus protein 4
- Alpha-N-acetylglucosaminidase
- Vesicle-trafficking protein SEC22b
- Syntaxin-5
Sequence:
MAVELGVLLVRPRPGTGLGRVMRTLLLVLWLATRGSALYFHIGETEKKCFIEEIPDETMVIGNYRTQLYDKQREEYQPATPGLGMFVEVKDPEDKVILARQYGSEGRFTFTSHTPGEHQICLHSNSTKFSLFAGGMLRVHLDIQVGEHANDYAEIAAKDKLSELQLRVRQLVEQVEQIQKEQNYQRWREERFRQTSESTNQRVLWWSILQTLILVAIGVWQMRHLKSFFEAKKLV
Protein: Dachshund, isoform C (Q8IP21)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDSVTSEQSENNNNKAGAINNNINSGIERAAGNMNTTAMLMHHQQQQQAAAAAAAAAAQQQQQQHNGRDGSNSSRGANEDRPNGRSSHTGRGSSCSPASSPSRHPSAVSPVSSLNHSMMQQMQQQQQQQQQQQQQQQHHQLSPPPHGMPSGNGLPTGLPPRMPHGLPPHSLGLLNSLQMMHHASPLELMAAAHHHVPPRSYNSPPPISTSDPSANECKLVEYRGQKVAAFIISNETMLCLPQAFELFLKHLVGGLHTVYTKLKRLDIVPLVCNVEQVRILRGLGAIQPGVNRCKLLCCKDFDILYRDCTTASSRPGRPPKRGPVGLSLPPTHLSQHPQLKKHRLDNGDYAYENGHISDMKSPLLANGYNPPPINHMAFMQMNAHHPGAAALMSPGMPPHGLHARPESQMLKAAAQNAGMSAANMDALARSGIWENCRAAYEDIVKHLERLREERTDERQQAMGVGGAVVDRVGNVMVAEHKPRDLSSRNCSPTRQSPVLNLSKSGGNTDHGGSNCDAGSERSDCHSVAGSPARGGSRSLDEGSRSGVGGGVASHVGGGIIGVEDDEEEEENLSDENQSEVDERCLAKDDEDLSDTERDNLSTGSAAAAAAAAAAAAHQLHQHAASHHHQTVGLSHLGVVPPHQRGSPSSAEAAAAALQHQRALNYSQLAAAAAVANGAAVGGGAVANGPTGGGGALTPNEALLAANDAAALAGGLALGPLGIDAHAAVPASSTETLLRNIQSLLKVAADNARQQERQISYEKAELKMDVLREREVKDSLERQLVDERKLRVLYQKRFRRERKIRIRYQQQLGGGSGAVKGSPNANGSGGGGSGSACSESEACGGGGGDAKCNNNNNNNNNNNNSNSSSHGGDVETMKENDAGSEKSDKSLASNSSCDVTAGHSAGSVSGSISAGLNCPDSPTHFKREPSSDHEGSVERQPRSSAASLAAHDEDNTKRCGSRDRDERPPSGSAASVAAEGSLAAAAAAAAAAAAAAASNGKGPWSYPGIDLMATGAFWQNYSESLAQELEMERKSRAANAERDVKSPLSERPTAYYKNSVLFGSAN
Protein: SSB protein (Gene product 34) (Gp34) (Single-stranded DNA binding protein) (Q6JM09)
Organism: Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)
Function: Binds ssDNA with nanomolar affinity but no sequence specificity.
Interaction partners:
Sequence:
MAIITVTAQANEKNTRTVSTAKGDKKIISVPLFEKEKGSNVKVAYGSAFLPDFIQLGDTVTVSGRVQAKESGEYVNYNFVFPTVEKVFITNDNSSQSQAKQDLFGGSEPIEVNSEDLPF
Protein: V-type sodium ATPase subunit K (Na(+)-translocating ATPase subunit K) (Sodium ATPase proteolipid component) (P43457)
Organism: Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R)
Function: Involved in ATP-driven sodium extrusion.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MMDYLITQNGGMVFAVLAMATATIFSGIGSAKGVGMTGEAAAALTTSQPEKFGQALILQLLPGTQGLYGFVIAFLIFINLGSDMSVVQGLNFLGASLPIAFTGLFSGIAQGKVAAAGIQILAKKPEHATKGIIFAAMVETYAILGFVISFLLVLNA
Protein: G6f-like (E0XMD3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRKNDQAFIIVSFGLCVIFSPLMAGDVWNDVVMAREDTSVTMSCFKSPPTSSIMVTWKMMSVREDRWSYLLSANCIDGQTDGRRSRVFGGRTFEISADASLNFIAAVATQGRYSCVVEQDDKKLQEKIVLLALVKLSVTPTPPVTVDRTLRLAAQVSPASVAAGGTWVSPSGELLYTEISHGMGRLLSKLPRVTSKDSGVYTCRIRVHGNSSTSDSEHRVNVTVNVRAVFSFTDVTHGESRSMAVLSRSVVTITCPSVLGDYVLLYWEYPDSKRMELIFQYDRWRRSYTNQTKLHLQFTGSASLATAGNFSFSLSPSLKDGGVYLCEVFLDDKAFSQANKLSVLHGYTSSSRGSLDLSCMYSERSQVKSVRWSYVQDPKRTLQTTAVMGKITTSVALPVTSKTAGQYACTLYLENGKSVQYMHTVTKTAPTVSPGPALPPADDISVHSYVSTFSFLLLLIPVIAAAVGVLLWKRGYCVTRRSVEQSLSYHSGEVENIYENPDDLRQTPPQGAVYMDLKPTGEMDVYKELERYNQCCG
Protein: Monoterpene synthase 8, chloroplastic (HcTPS8) (Alpha-bergamotene synthase) (EC 4.2.3.81) (Alpha-curcumene synthase) (EC 4.2.3.-) (Beta-bisabolene synthase) (EC 4.2.3.55) (Beta-farnesene synthase) (EC 4.2.3.47) (Beta-sesquiphellandrene synthase) (EC 4.2.3.123) (Cis-alpha-bisabolene synthase) (EC 4.2.3.38) (Linalool synthase) (EC 4.2.3.25, EC 4.2.3.26) (U5PZT6)
Organism: Hedychium coronarium (White butterfly ginger-lily)
Function: Sesquiterpene and monoterpene synthase involved in the biosynthesis of volatile compounds present in floral scent. Mediates the conversion of (2E)-geranyl diphosphate (GPP) into linalool, with trace levels of myrcene, limonene and (Z)-beta-ocimene. Acts also as a sesquiterpene synthase by catalyzing the conversion of farnesyl diphosphate (FPP) to alpha-bergamotene and beta-bisabolene and to minor products including alpha-curcumene, cis-alpha-bisabolene, beta-farnesene and beta-sesquiphellandrene, as well as seven other unidentified sesquiterpenes.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:25056927}.
Interaction partners:
Sequence:
MSLLLAPPSYFPFRGLRRSTAAKQPPCLRLVKCTADRQSPEAARRSAHYQPNMWSDDYIQSLTVESPLKVEEKEQTKKLMLLKERIAEVICEGKEVEEQLRLIDHLQQLGVAYHFKDDIKASLRNIHSSLEEISSTIIFKDGLHASALLFRLLRENGFSISEDIFEEFRDEKGQYFRSDGLKNQTDQAMLSLYEASYYEKDGEMVLQEAMECTTKHLENLLEEEGSDLKLKEQAAHALELPLNWRMERLHARWFIEACQREVMVIDNPLLLEFAKLDFNAVQSIYKKELSALSRWWTKLGVVEKLPFARDRLTENYLWTVGWAFEPEHWSFRDAQTKGNCFVTMIDDVYDVYGTLDELELFTHVVDRWDINAIDQLPDYMKILFLALFNTVNDDGYKVMKEKGLDVIPYLKRSWADLCKAYLVEAKWYHRGYKPTINEYLDNTWISISGPAIFTNAYCMANNLTKQDLERFSEYPAIAKHSSMLGRLYNDLATSTAEIERGDVPKSIQCCMHERGVSEGVAREQVKELIRGNWRCMNGDRAAASSFEEMLKTVAVDIARASQFFYHNGDKYGKADGETMTQVMSLLINPII
Protein: E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RING1) (Sex comb extra protein) (dRING protein) (dRING1) (Q9VB08)
Organism: Drosophila melanogaster (Fruit fly)
Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG complexes act via modification of histones, such as methylation, deacetylation, ubiquitination rendering chromatin heritably changed in its expressibility. May play a role in meiotic sister chromatid cohesion.
Subcellular location: Nucleus. Chromosome. Note=Colocalizes with ubiquitinated histone H2A. Colocalizes with Pc, Pcl, Psc, ph at many sites on polytene chromosomes. Colocalizes with ORD on the chromatin of primary spermatocytes during G2 of meiosis.
Interaction partners:
- Polycomb group protein Psc
- Polycomb group protein Pc
- Protein suppressor 2 of zeste
- GEO03726p1
- JmjC domain-containing histone demethylation protein 1
- Polycomb protein esc
- Polyhomeotic-proximal chromatin protein
- Histone-lysine N-methyltransferase E
- Polycomb protein Su
- Polycomb protein Sfmbt
Sequence:
MTSLDPAPNKTWELSLYELQRKPQEVITDSTEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYPSREEYEAIQEKVMAKFNQTQSQQALVNSINEGIKLQSQNRPQRFRTKGGGGGGGGGGNGNGAANVAAPPAPGAPTAVGRNASNQMHVHDTASNDSNSNTNSIDRENRDPGHSGTSAASAITSASNAAPSSSANSGASTSATRMQVDDASNPPSVRSTPSPVPSNSSSSKPKRAMSVLTSERSEESESDSQMDCRTEGDSNIDTEGEGNGELGINDEIELVFKPHPTEMSADNQLIRALKENCVRYIKTTANATVDHLSKYLAMRLTLDLGADLPEACRVLNFCIYVAPQPQQLVILNGNQTLHQVNDKFWKVNKPMEMYYSWKKT
Protein: Proline-rich receptor-like protein kinase PERK5 (EC 2.7.11.1) (Proline-rich extensin-like receptor kinase 5) (AtPERK5) (Q8GX23)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Proline-rich family protein
- Hydroxyproline-rich glycoprotein family protein
- Uncharacterized protein
- Uncharacterized protein
- Zinc finger
- Zinc knuckle
- Protein NETWORKED 1D
- Protein RALF-like 4
- Cytochrome B561, amino-terminal protein
- Armadillo repeat only 1
Sequence:
MADSPVDSSPAPETSNGTPPSNGTSPSNESSPPTPPSSPPPSSISAPPPDISASFSPPPAPPTQETSPPTSPSSSPPVVANPSPQTPENPSPPAPEGSTPVTPPAPPQTPSNQSPERPTPPSPGANDDRNRTNGGNNNRDGSTPSPPSSGNRTSGDGGSPSPPRSISPPQNSGDSDSSSGNHPQANIGLIIGVLVGAGLLLLLAVCICICCNRKKKKKSPQVNHMHYYNNNPYGGAPSGNGGYYKGTPQDHVVNMAGQGGGNWGPQQPVSGPHSDASNLTGRTAIPSPQAATLGHNQSTFTYDELSIATEGFAQSNLLGQGGFGYVHKGVLPSGKEVAVKSLKLGSGQGEREFQAEVDIISRVHHRHLVSLVGYCISGGQRLLVYEFIPNNTLEFHLHGKGRPVLDWPTRVKIALGSARGLAYLHEDCHPRIIHRDIKAANILLDFSFETKVADFGLAKLSQDNYTHVSTRVMGTFGYLAPEYASSGKLSDKSDVFSFGVMLLELITGRPPLDLTGEMEDSLVDWARPLCLKAAQDGDYNQLADPRLELNYSHQEMVQMASCAAAAIRHSARRRPKMSQIVRALEGDMSMDDLSEGTRPGQSTYLSPGSVSSEYDASSYTADMKKFKKLALENKEYQSSEYGGTSEYGLNPSASSSEEMNRGSMKRNPQL
Protein: Rhodopsin (P22328)
Organism: Gallus gallus (Chicken)
Function: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P08100}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08100}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P08100}. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia. {ECO:0000250|UniProtKB:P08100}.
Interaction partners:
- Uncharacterized protein.
- G protein-coupled receptor kinase
- G protein subunit alpha transducin 2
- G protein subunit beta 1
- S-antigen visual arrestin.
- Green-sensitive opsin
- G protein subunit beta 3
- Rhotekin.
- Retinoid isomerohydrolase
- Cone-rod homeobox
Sequence:
MNGTEGQDFYVPMSNKTGVVRSPFEYPQYYLAEPWKFSALAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLGGEIALWSLVVLAVERYVVVCKPMSNFRFGENHAIMGVAFSWIMAMACAAPPLFGWSRYIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFMIPLAVIFFCYGNLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTNQGSDFGPIFMTIPAFFAKSSAIYNPVIYIVMNKQFRNCMITTLCCGKNPLGDEDTSAGKTETSSVSTSQVSPA
Protein: V-maf musculoaponeurotic fibrosarcoma oncogene homolog K (Avian) (Q6IRI7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- BTB domain and CNC homolog 1
- Nuclear factor erythroid 2-related factor 2
- Transcription factor NF-E2 45 kDa subunit
- BTB domain and CNC homolog 2
- Transcription factor MafG
- Histone deacetylase 3
- MAF bZIP transcription factor F
- Endoplasmic reticulum membrane sensor NFE2L1
Sequence:
MTTNPKPNKTLKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVTPTKVATTSVITIVKSAELSSTSVPFSAAS
Protein: Enolase, putative (EC 4.2.1.11) (Q381E5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Pyruvate kinase
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
- Glucose-6-phosphate isomerase
- Transketolase
- Fructose-bisphosphate aldolase
- Pyruvate, phosphate dikinase
- phosphoenolpyruvate carboxykinase
- phosphopyruvate hydratase
- Transaldolase
- Triosephosphate isomerase
Sequence:
MESVSWKLYDNQHDLSGILTLAARSCVDSRALRPIEYLAAYFSTKCTGDEIRTLSAHVMFAPGGCRVLRIILRLLNGMEVQSSALLSASQELGDSLVEHTVDPAVIHEVLQESYFPRLVPCRACDQRQFDEILSRVAATPDLPNVGTAVVHALSVVASAAASRCTSTPAFQYLRNTFGLLTDVETFSMPQLCIDFFGPENVATARVALKSVLILPCMPNGTVSHEVMQKIFAAFNHFRKVHNAATRSDGSLVFSTFDNITDAINLADEVLRAVELRPQTDVCLGLRLAAPATRTQKEAKDGGEVFYSMFPGEQDITGSQLAEYVREQVQASANLVVYVEDTHCDVDTIGLRRLHATIGGTAVFSGYDLYRRSKYEKVEQGLDELWTSNVVLEASAIGSLSALCDNVRMVRRHEGCTIALAPQSLMHNVAFAVHLAVGVGARFLCVGGLMDVVQCEVVSQYLYVQDELEQSRLLLEEAPKPPCAVLPDAPTDTVPEIKRRLDKKKRKK
Protein: Delayed-rectifier potassium channel regulatory subunit KCNS1 (Delayed-rectifier K(+) channel alpha subunit 1) (Delayed-rectifier potassium channel subunit Kv9.1) (hKv9.1) (Potassium voltage-gated channel modifier subfamily S member 1) (Q96KK3)
Organism: Homo sapiens (Human)
Function: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10484328}; Multi-pass membrane protein {ECO:0000305}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:10484328). {ECO:0000269|PubMed:10484328}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Potassium channel subfamily K member 15 channel 5)
- Potassium voltage-gated channel subfamily B member 1
- Potassium voltage-gated channel subfamily B member 2
- Voltage-gated potassium channel subunit beta-2
Sequence:
MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY
Protein: protein deglycase (EC 3.5.1.124) (Maillard deglycase) (Parkinsonism-associated deglycase) (Protein DJ-1) (Protein/nucleic acid deglycase DJ-1) (K7EN27)
Organism: Homo sapiens (Human)
Subcellular location: Membrane raft {ECO:0000256|ARBA:ARBA00004285}.
Interaction partners:
Sequence:
GKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGCHLFCFYFAGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLKD
Protein: PH-sensitive chloride channel 1, isoform D (Q9VUV2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGCVFEAAKEQPHKPRSRQLRRNQCRGKAEKAAAGTRGKVAVRGNNDKPAEDIKIKDNYQQNHKTQTETQTEVAAVVAIATDAGAETETETEAEAQKEPATGPEHLKAAAQVLLTIRQARQENNKHSSSQVAETHKDEGEDALARQGSIVDTAAGRIGIDIAATTIQVAERHEDGQHWQQHNVRRRRRQPDPAAHPASITKLSAISLHFHALAALAKTLQKHEDLSPVQDRQPLAYRAWQEHPYAETQMPATMSAAIIANVGATAAATSAAAFQYLGQHYKHYSQSISFYAASSVLLMLCYLTTASTAAATQSETGALDKHPIHGIDWSKFDESSSDKEILDLLLEKKRYDKRLLPPVNGTLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHHDSIWTPDTYFIMHGDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLTTLNAYLIKNQTTACDQNSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQPGEKRQNAGAPNEIVACTTCGGSNSPCTHSANNGCATETCFVQVRKKEPPHPIRVAKTIDVIARITFPTAYAIFLIFFFVHYKGFS