wanglab/gogpt-training-data huggingface dataset:
Protein: DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (Q8VHM6)
Organism: Rattus norvegicus (Rat)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O75575}. Cell membrane {ECO:0000250|UniProtKB:O35427}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35427}; Cytoplasmic side {ECO:0000250|UniProtKB:O35427}.
Interaction partners:
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- RNA polymerase III subunit E
- RNA polymerase I and III subunit C.
- DNA-directed RNA polymerase III subunit RPC3
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase subunit
- RNA polymerase III subunit D
- DNA-directed RNA polymerase subunit beta
Sequence:
MEVKDANAALLSNYEVFQLLTDLKEQRKESGKNKHSAGQQNLNAITYETLKYISKTPCKNQSPAIVQEFLTAMKSHKLTKAEKLQLLNHRPMTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAGPEDEQSKSTSNDAAMEEEEPA
Protein: Large ribosomal subunit protein mL64 (39S ribosomal protein L59, mitochondrial) (MRP-L59) (CKII beta-associating protein) (CR6-interacting factor 1) (CRIF1) (Growth arrest and DNA damage-inducible proteins-interacting protein 1) (Papillomavirus L2-interacting nuclear protein 1) (PLINP) (PLINP-1) (p53-responsive gene 6 protein) (Q8TAE8)
Organism: Homo sapiens (Human)
Function: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}. Nucleus {ECO:0000269|PubMed:12482659}. Note=Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). {ECO:0000269|PubMed:12482659, ECO:0000269|PubMed:22453275}.
Interaction partners:
- Large ribosomal subunit protein mL62
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL28m
- Mitochondrial ribosomal protein L40
- Large ribosomal subunit protein mL41
- Growth arrest and DNA damage-inducible protein GADD45 alpha
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein mL51
- Large ribosomal subunit protein bL33m
Sequence:
MAASVRQARSLLGVAATLAPGSRGYRARPPPRRRPGPRWPDPEDLLTPRWQLGPRYAAKQFARYGAASGVVPGSLWPSPEQLRELEAEEREWYPSLATMQESLRVKQLAEEQKRREREQHIAECMAKMPQMIVNWQQQQRENWEKAQADKERRARLQAEAQELLGYQVDPRSARFQELLQDLEKKERKRLKEEKQKRKKEARAAALAAAVAQDPAASGAPSS
Protein: Gonadotropin releasing hormone receptor 4 isoform X1 (Gonadotropin-releasing hormone receptor 4) (Gonadotropin-releasing hormone receptor GnRH-R4SHS) (A3QJZ0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Progonadoliberin
- Progonadoliberin
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit alpha
- Follicle-stimulating hormone beta subunit
- Gonadotropin-releasing hormone receptor 1
- Gonadotropin-releasing hormone receptor 2.
- Lhb protein
- KiSS-1 metastasis suppressor
- Prokineticin
Sequence:
MNDSSPTSENIMFHQLTADTLNGSCDLPTCNNNTGEAALQLPTFSMAAKVRVIITFTLCAVSAVCNLGVLWAASTNNKRKSHVRILIMNLTVADLLVTFIVMPVDAAWNITVQWLAGDLACRLLMFLKLVAMYSCAFVTVVISLDRQSAILNPLAINKAKKKNKIMLSVAWAMSVVLSVPQMFLFHNVTITVPANFTQCTTRGSFVKHWQETIYNMFTFICLFLIPLAIMICCYTRILVEISRRMTKGNISSKEVHLRRSHSNIPKARMRTLKMSIVIVTSFIVCWTPYYLLGLWYWFLPEDLEETVSHSLTHMLFIFGLFNAILDPITYGLFTIHFRKGLKRYCRSAVVLTESENNSIITGSLKCSPSPFRMKRVTQSGTGTDPKQNTSTVGEEDKKAADGKTKE
Protein: Rhodanese-like domain-containing protein 10 (Sulfurtransferase 10) (AtStr10) (Q9SR92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- 3-dehydroquinate synthase, chloroplastic
- Putative inactive
Sequence:
MTVLLPQLNHIHKLPVVLNRRLRQSYRLPVISAVSGKELILSGKVRAVEPKEANAVVASEGYILLDVRPAWEREKARVKGSLHVPLFVEDPDNGPITLLKKWIHLGYIGLWTGQRFTMINDEFALRVVEAVPDKESKVLVVCGEGLRSLAAVSKLHGEGYKSLGWLTGGFNRVSEGDFPEIEGTEELRFATIGGVSFYLLKLLVLLPSFGQKSR
Protein: Ras-related protein Rab-7b (Q6DUB4)
Organism: Paramecium octaurelia
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22030555}. Note=Localizes to the oral apparatus where it is associated with microtubules. {ECO:0000269|PubMed:22030555}.
Interaction partners:
Sequence:
MASQKKQLFKIIILGDSGVGKTSLMNQYVNARFTQQYRATVGADFMAKEVMIDDRMVTLQIWDTAGQERFQSLGGAFYRGADCCVLVYDITNPKSFDSLDSWRDEFLMQGQPKDPEHFPFVVLGNKLDKATERKVQESKSQQWCKSHGNIQFFEVSAKDATNIEQAFQDIAKAAASQEKDEEIFFPTTVTLTKQDPKKQTKQGGCC
Protein: Phosphoinositide-3-kinase-interacting protein 1 (PI3K-interacting protein 1) (Kringle domain-containing protein HGFL) (Q96FE7)
Organism: Homo sapiens (Human)
Function: Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19088825}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MLLAWVQAFLVSNMLLAEAYGSGGCFWDNGHLYREDQTSPAPGLRCLNWLDAQSGLASAPVSGAGNHSYCRNPDEDPRGPWCYVSGEAGVPEKRPCEDLRCPETTSQALPAFTTEIQEASEGPGADEVQVFAPANALPARSEAAAVQPVIGISQRVRMNSKEKKDLGTLGYVLGITMMVIIIAIGAGIILGYSYKRGKDLKEQHDQKVCEREMQRITLPLSAFTNPTCEIVDEKTVVVHTSQTPVDPQEGTTPLMGQAGTPGA
Protein: Probable O-methyltransferase Omt (O06551)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- DUF1697 domain-containing protein
Sequence:
MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMAVALVESIDFDFAKFGPTGQGFALRARAFDMAAQHYLDQHPAATVVALAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLPPRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG
Protein: Anther-specific protein BCP1 (Q9FYL2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Major pollen protein required for pollen fertility and development. Active in both diploid tapetum and haploid microspores.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Protein PLANT CADMIUM RESISTANCE 11
- Putative proline-rich receptor-like protein kinase PERK6
- Proline-rich receptor-like protein kinase PERK7
- F-box protein At3g62230
- Notchless protein homolog
- Putative proline-rich receptor-like protein kinase PERK11
- Proline-rich family protein
- Nucleolar complex-associated protein 2
- Tubby-like F-box protein 6
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
Sequence:
MGRQNIVVVVALVFMAIIGLAAAASSPSPSASPSKAPAASKTDHVEAPVTDDQIGTTDDDAAPTPGDGDVAVAGPLGSDSSYDNAPTGSADSAKSGAAALGVSAVVVGVTSIAGSFLLL
Protein: Major capsid protein 1 (MCP1) (Major capsid protein VP1) (A0A6M3VZT9)
Organism: Pyrobaculum filamentous virus 2 (PFV2)
Function: Self-assembles to form a helical, filamentous nucleocapsid mesuring 400 nm in length and 20 nm in width (Probable). Together with capsid protein 2, wraps arounds the DNA and maintains it in an A-form (Probable). Capsid proteins probably maintain the DNA in A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues (Probable). This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).
Subcellular location: Virion {ECO:0000269|PubMed:32368353}.
Interaction partners:
Sequence:
MSVVTTRARIAETLTEKHTLGIEKVVATDSWRVGITSREKKLERINISAEISRRIQDEAIAYARNKGIPYLPGINGIAWKLLRLKWLGYTDQINVVMRTVPAEWRDFLTQIMENTQMESMYSELRKVRV
Protein: Fructokinase (EC 2.7.1.4) (D-fructose kinase) (Manno(fructo)kinase) (P23917)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the phosphorylation of fructose to fructose-6-P. Has also low level glucokinase activity in vitro. Is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine.
Interaction partners:
- PTS system fructose-specific EIIB'BC component
- Mannose-6-phosphate isomerase
- Glucose-6-phosphate isomerase
- Xylose isomerase
- Mannitol-1-phosphate 5-dehydrogenase
- ATP-dependent 6-phosphofructokinase isozyme 1
- ATP-dependent 6-phosphofructokinase isozyme 2
- Glutamine--fructose-6-phosphate aminotransferase
- Glucosamine-6-phosphate deaminase
- Fructose-1,6-bisphosphatase 2 class 2
Sequence:
MRIGIDLGGTKTEVIALGDAGEQLYRHRLPTPRDDYRQTIETIATLVDMAEQATGQRGTVGMGIPGSISPYTGVVKNANSTWLNGQPFDKDLSARLQREVRLANDANCLAVSEAVDGAAAGAQTVFAVIIGTGCGAGVAFNGRAHIGGNGTAGEWGHNPLPWMDEDELRYREEVPCYCGKQGCIETFISGTGFAMDYRRLSGHALKGSEIIRLVEESDPVAELALRRYELRLAKSLAHVVNILDPDVIVLGGGMSNVDRLYQTVGQLIKQFVFGGECETPVRKAKHGDSSGVRGAAWLWPQE
Protein: Fibronectin (Q3UGY5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLRGPGPGRLLLLAVLCLGTSVRCTEAGKSKRQAQQIVQPQSPVAVSQSKPGCFDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEPEETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDKWRRPHETGGYMLECLCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHALQSASAGSGSFTDVRTAIYQPQTHPQPAPYGHCVTDSGVVYSVGMQWLKSQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHAVLVQTRGGNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGRGIGEWHCQPLQTYPGTTGPVQVIITETPSQPNSHPIQWNAPEPSHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYGHREVTRFDFTTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWTPPDSVVSGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPGSEYTVTLVAVKGNQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVVHADQSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTVVPAVPPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSSDITANSFTVHWVAPRAPITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGREESPPLIGQQATVSDIPRDLEVIASTPTSLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKPVSINYKTEIDKPSQMQVTDVQDNSISVRWLPSTSPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIRELFPAPDGEDDTAELQGLRPGSEYTVSVVALHDDMESQPLIGIQSTAIPAPTNLKFSQVTPTSFTAQWIAPSVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVITTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANGQTPVQRSISPDVRSYTITGLQPGTDYKIHLYTLNDNARSSPVIIDASTAIDAPSNLRFLTTTPNSLLVSWQAPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFITNPGYDTENGIQLPGTTHQQPSVGQQMIFEEHGFRRTTPPTAATPVRLRPRPYLPNVDEEVQIGHVPRGDVDYHLYPHVPGLNPNASTGQEALSQTTISWTPFQESSEYIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEALQNQRRHKVREEVVTVGNAVSEGLNQPTDDSCFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKWCHDNGVNYKIGEKWDRQGEDGQRMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGAAEPSPDGTTGHTYNQYTQRYNQRTNTNVNCPIECFMPLDVQADRDDSRE
Protein: glycerol kinase (EC 2.7.1.30) (Q0VDQ2)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
Interaction partners:
Sequence:
MADAPKAVLGPLVGAVDQGTSSTRFLVFNPQTAELLCHHQVEIAQEFPKEGWVEQDPKAILQSVYECIEKACEKLGQQSIDISNIKAIGVTNQRETTIVWDKFTGEPLYNAVVWLDLRTQSTVENLSKSISVSNNFVKNKTGLPISTYFSAVKLHWLIENVRKVQKAIEDGRAIFGTVDSWLIWCMTGGINGGVHCTDVSNASRTMLFNIHSLQWDEELCDFFGIPMTILPRIRSSSEIYGLVKSGVLEGVPISGCLGDQSAALVGQLCLQDGQAKSTYGTGCFLLCNTGQKCVNSEHGLLTTVAYQLGRQEPVYYALEGSVAIAGAVVSWIKNNLQIIQSSSEIEKLAEVAGTSYGCYFVPAFSGLYAPYWDPSARGIICGLTQFTNKFHIAFAALEAVCFQTREILDAMNSDCGIPLTHLQVDGGMTANRVLMQLQADILCIPVMKPFMPETTALGVAMAAGAAEGVSVWSLDPKDLSSVQMEKFEPQINVEESEGRYATWKKAVLKSMGWVLTQSPDGRDPSIFSSLTLGFYVVSSMVILIGARYM
Protein: Protein Wnt (Q9DEB8)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
- Low-density lipoprotein receptor-related protein
- Wnt inhibitory factor 1
- Porcupine O-acyltransferase.
- Frizzled-4
- Frizzled-7
- Frizzled-6
- Notum, palmitoleoyl-protein carboxylesterase.
- Frizzled-1
- Cerberus
- Frizzled-3
Sequence:
MNRKTRRWIFHIFLSLGIVYIKIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGINECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHKEEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVQVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRMCNKTAQQSNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK
Protein: At4g14020 (Rapid alkalinization factor (RALF) family protein) (O23263)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Protein RALF-like 35
- Protein RALF-like 17
- Protein RALF-like 36
- UDP-URONIC ACID TRANSPORTER 1
- Transmembrane protein
- Transmembrane protein
- UDP-rhamnose/UDP-galactose transporter 2
- Rapid alkalinization factor 23
- Probable sugar phosphate/phosphate translocator At5g05820
- GPI-anchored protein LLG2
Sequence:
MEYYTFTENDEERVSRNHHVNNTWVKERYESDEEDGEVNKLILKEDEETKDMVTSPSGERMMLTSKVRYLTYGALKHDTAASAASGGGGRALPHPSNKYNRGHPKYYRCRG
Protein: Cytidine deaminase (CDD) (EC 3.5.4.5) (Cytidine aminohydrolase) (CDA) (P9WPH3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Recycles cytidine and 2-deoxycytidine for uridine and 2-deoxyuridine synthesis, respectively. Catalyzes the hydrolytic deamination of cytidine and 2-deoxycytidine to form, respectively, uridine and 2-deoxyuridine.
Interaction partners:
- Thymidine phosphorylase
- Adenosine deaminase
- Purine nucleoside phosphorylase
- Uracil phosphoribosyltransferase
- AB hydrolase-1 domain-containing protein
- Deoxyribose-phosphate aldolase
- Succinate dehydrogenase 2 membrane subunit SdhC
- Probable succinate dehydrogenase SdhD
Sequence:
MPDVDWNMLRGNATQAAAGAYVPYSRFAVGAAALVDDGRVVTGCNVENVSYGLTLCAECAVVCALHSTGGGRLLALACVDGHGSVLMPCGRCRQVLLEHGGSELLIDHPVRPRRLGDLLPDAFGLDDLPRERR
Protein: E3 ubiquitin-protein ligase (EC 2.3.2.26) (A0A8I6AIV5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MATGLGEPIYGLSEEEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGPEPWETISEEVNMAGDSLSLALPPPPASPVSRTSPQELSEELSRRLQITPDSNGEQFSALIQREPSSRLRSCSVTDTVAEQAHLPPGAKDSPIRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Protein: DNA-binding protein RFX2 (Regulatory factor X 2) (Q5EAP5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor that acts as a key regulator of ciliogenesis. Specifically regulates expression of genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:B2GV50, ECO:0000255|PROSITE-ProRule:PRU00858}. Cytoplasm {ECO:0000250|UniProtKB:B2GV50}. Note=Mainly expressed in the nucleus and at lower level in cytoplasm. {ECO:0000250|UniProtKB:B2GV50}.
Interaction partners:
- Forkhead box protein J1-A
- Multicilin
- ATR serine/threonine kinase
- Intraflagellar transport 88 homolog.
- Highly divergent homeobox
Sequence:
MQRSEGGSETPSTVALRTSTSAQAPVVQPVPASQQRVLVQATGSSQKGAQVQQLPVPRVQQVPQQVQQVQHYHSQQVQYVEGAEAVYPNGTIRAAYSYNPESQLYGQGSGSAYFDSQAGGAQVTTVVSSGGVPTHGMVGIAMDVGGSQIISSGSAYLIHGGMEGGRHHTSHSSRSSSAMLEMAIENLQKSEGIATHKSSLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEQKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRMQEDTQYMAMRQTPVHQKQRFKPFHKMDGMGDSLNSGSQHLSSTPEQSVAAQCQHHQQYIDVSHVLPPFPSLDLGSCPLPESISMTDVKKLQSSYRIHCEATLDVVMNLQFHLIEKLWQTFWHSTAPSSDGATTIPNSEEDVEDIRGFPRDKLITLCKYEPIKQWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTSAMTNFPPEIISTKAAVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDESVVQRLELDFKATLQQQSSLDQWAAWLDNVVNQVLKPYDGSLSFPRAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFSDLSSLMPSLKEQDTSFSDDMTSDGDMSRMSERSLTEPAVKRERIEIPHSLQEI
Protein: Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) (P61080)
Organism: Mus musculus (Mouse)
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P51668}.
Interaction partners:
- E3 ubiquitin-protein ligase CHIP
- E3 ubiquitin-protein ligase RBX1
- E3 ubiquitin-protein ligase RNF4
- E3 ubiquitin-protein ligase Mdm2
- Ubiquitin thioesterase OTUB1
- Anaphase-promoting complex subunit 11
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-conjugating enzyme E2 variant 1
- Cell division cycle protein 23 homolog
Sequence:
MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM
Protein: Peptide YY (PYY) (Peptide tyrosine tyrosine) [Cleaved into: Peptide YY(3-36) (PYY-II)] (Q9EPS2)
Organism: Mus musculus (Mouse)
Function: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Subcellular location: Secreted.
Interaction partners:
- Neuropeptide Y receptor type 2
- Pancreatic polypeptide prohormone
- Pro-neuropeptide Y
- Neuropeptide Y receptor type 1
- Neuropeptide Y receptor type 5
- Appetite-regulating hormone
- Pro-glucagon
- Pro-opiomelanocortin
- Neuropeptide Y receptor type 4
- Somatostatin
Sequence:
MVAVRRPWPVTVAMLLILLACLGALVDAYPAKPEAPGEDASPEELSRYYASLRHYLNLVTRQRYGKRDVPAALFSKLLFTDDSDSENLPFRPEGLDQW
Protein: adenylate cyclase (EC 4.6.1.1) (G0TC75)
Organism: Bos taurus (Bovine)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAVLYKYPVLDCEVEDHVAFLITVPTALAIFFAIFTLVCVESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGAKEHLVWQILANVVIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTPANHMEAGGVPGRVHISSVTLQHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPYAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKIIEKEYRATALPAFKYYVTCACLIFFCIFIVQVLVLPKTSILGISFGAAFLSLAFILFVCFAGQLLQCSKKASASLLWLLKSSGIIANRPWPRISLTVITTAIILTMAVFNMFFLSDSEETILPTANASNTSLSGASNQAAIPRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMAALVGYNTIFLHTHAPLLDDYSQVLFERPGIWKDLKTMGSVSLFIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHAQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNGFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKI
Protein: Uncharacterized protein (Q86LA4)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Alpha-L-fucosidase
Sequence:
MKILYLIFTILILINFTFANDGFVLVTPMGTGEECSSTPYGEGYYLPTGTEITIDYECYQFDFVNSSTHLQVQYLGKNCTAEHPSVTIFPMNECVDFKIKEDDLSFMSIITANDVIPEQSISYVYYYYSNFCSGPTYQLFFTNGYSNEYSKYQCVNGKPQVFVCTDSGSCTPIDASGCTNKNVPIPYRVEC
Protein: Ribosomal protein L13 family protein (F4JD96)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVSGSGICAKRVVVDARHHMLGRLASVVAKDLLNGQNIVVVRCEEICLSGGLVRQKMKYMRFLRKRMNTKPSHGPIHFRAPSKIFWRTVRGMIPHKTKRGANALARLKVFEGVPTPYDKIKRMVVPDALKVLRLQAGHKYCLLGRLSSEVGWNHYDTIKQELENKRKERAQAVYERKKQLSKLRAKAEKVAEEKLGSQLDVLAPVKY
Protein: Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) (P30560)
Organism: Rattus norvegicus (Rat)
Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Located in cytoplasmic vesicles dispersed throughout the cell cytoplasm and to the plasma membrane.
Interaction partners:
- Vasopressin-neurophysin 2-copeptin
- Oxytocin-neurophysin 1
- Guanine nucleotide-binding protein G
- Vasopressin V2 receptor
- Vasopressin V1b receptor
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit alpha-13
- Angiotensinogen
- Pro-opiomelanocortin
Sequence:
MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST
Protein: MUC1 isoform M10 (Mucin 1, cell surface associated) (A6ZIE4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTPGTQSPFFLLLLLTVLTATTAPKPATVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAFNSSLEDPSTDYYQELQRDISEMSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPARDTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAATSANL