wanglab/gogpt-training-data huggingface dataset:
Protein: Small ribosomal subunit protein uS11m (Probable ribosomal protein S11, mitochondrial) (MRP-S11) (S11mt) (Protein NUCLEAR FUSION DEFECTIVE 3, mitochondrial) (Q8VZT8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus.
Subcellular location: Mitochondrion {ECO:0000255, ECO:0000303|PubMed:36423343}.
Interaction partners:
- Small ribosomal subunit protein mS29
- Uncharacterized protein
- Small ribosomal subunit protein uS13m
- Small ribosomal subunit protein bS18c
- Small ribosomal subunit protein mS78
- At1g64880
- Small ribosomal subunit protein uS2m
- AT3g18240
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS10m
Sequence:
MNGVSRHLRASSLLSLIRSYGGINSVCRFSSQSDGFSGGRFREQVPVSGESANNSGLSNTGRIGSSPEPNPSTLRTFGDMKAGLLNRGVNGFSAPNAPPTFKSSLRSRLPNSLPDQFGQTNPGLPNTGGSGFSAPSLSSYENFTQSSSLLKENSRSGGKSSDLDFVREVIEDEGRRTAGIFSHFQRPNLETNADIIHIKMLRNNTFVTVTDSKGNVKCKATSGSLPDLKGGRKMTNYTADATAENIGRRAKAMGLKSVVVKVNGFTHFGKKKKAIIAFRDGFTNSRSDQNPIVYIEDTTRKAHNGCRLPRKRRV
Protein: Splicing factor cactin (O14342)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a role in pre-mRNA splicing by facilitating excision of introns featuring long spacing between the branchpoint and 3'-splice site (ss). Recruited to the spliceosome by sde2, which may enable folding of the RNA between the BP and 3'-ss to guide the splice site towards the spliceosome's catalytic center. Assists the splicing of several components involved in chromatin organization.
Interaction partners:
- Pre-mRNA-splicing factor cwf18
- Vacuolar ATPase assembly integral membrane protein vph2
- Uncharacterized protein C20H4.06c
- Uncharacterized WD repeat-containing protein C713.05
- Meiotically up-regulated gene 166 protein
- Pre-mRNA-splicing factor cwf19
- ER lumen protein-retaining receptor
- Uncharacterized mitochondrial carrier C17H9.08
- PWI domain-containing protein C825.05c
Sequence:
MAFRDSTRDFNRSRPEKRHASRSSSPRSFRPSNQNARANYNLPRVRDAMKEEERSRETKEMQEREFLRLQQLRRAIIRLKNDRSKPIDKLLVSVYLMPGPEWEENGEKNSIDFGTVDMFDPLSVIQSYKAEDLEEISRNIGDIQQLETNQCRLTYWKYVKMLVNSRMEHNKVGQFSRGLKVVAGEVQRILAPKSFEQLEQLEAQIQKKLKSNVPLDTDYWVDLLNSLKSYKAIAYLKKTFNEELQIRKNKLDNEEWDKAFSDAKKLSNMKDREEKLYIVPIDPKPILRAQAIPRRIQPEEQADYEKELNDHVNIVKSSTYIPISIPTQKQKPTLPKNSNLINEDEFSIANRARLEREYLQSDDAEEQEMLGDYVEGQTRVVNENGVTLKKPHYFNRVLLGFEWNSYNQAHFNEAHPPPKAVQGYRFNVFYPDLIGTGRAPTYRIERTRRKNKSDTTDLQDDVCIIRFIAGEPYQDIAFSIVDKDWDYSAKRDHGFKSSFDNGVLSLHFRFKKLHHRR
Protein: Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD antigen CD278) (Q9Y6W8)
Organism: Homo sapiens (Human)
Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:30523347}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Interaction partners:
- Ig-like domain-containing protein
- CD40 ligand
- ICOS ligand
- Cytotoxic T-lymphocyte protein 4
- T-lymphocyte activation antigen CD80
- T-lymphocyte activation antigen CD86
- Programmed cell death 1 ligand 1
- Tumor necrosis factor receptor superfamily member 5
- T-cell-specific surface glycoprotein CD28
- Phosphatidylinositol 3-kinase regulatory subunit alpha
Sequence:
MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCILICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL
Protein: Interferon alpha (B5M4C4)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAVPASPQHPRGYGILLLTLLLKALATTASACNHLRSQDATFSHDSLQLLRDMAPTLPQLCPQHNASCSFNDTILDTSNTRQADKTTHDILQHLFKILSSPSTPAHWNDSQRQSLLNRIHRYTQHLEQCLDSSDTRSRTRWPRNLHLTIKKHFSCLHTFLQDNDYSACAWEHVRLQARAWFLHIHNLTGNTRT
Protein: Acyl transferase (ACT) (EC 2.3.1.-) (C14ACP-TE) (Myristoyl-ACP-specific thioesterase) (P41302)
Organism: Photobacterium phosphoreum
Function: Acyl transferase is part of the fatty acid reductase system required for aldehyde biosynthesis; it produces fatty acids for the luminescent reaction.
Interaction partners:
- NADH dehydrogenase
- Long-chain acyl-protein thioester reductase
- Part of NADH-ubiquinone oxidoreductase complex I
- NADH dehydrogenase
- Alkanal monooxygenase alpha chain
- NADH dehydrogenase
- Acyl carrier protein
- Acyl carrier protein
- Acyl carrier protein
- Alkanal monooxygenase beta chain
Sequence:
MKSENNSVPIDHVIKVDNERHIRVWETFPKNQCDKRNNTIVIASGFARRMDHFAGLAEYLSTNGFHVIRYDSLNHVGLSSGEIDQFSMSVGKKSLLTVIDWLKSEHGIDQVGLIASSLSARIAYDIVADVNLSFLITAVGVVNLRNTLEQALKYDYLQMEIDEIPEDLDFDGYNLGSKVFVTDCFENNWDTLDSTINKTKNLNVPFIAFVANDDSWVQQHEVEELMSNINSDKTKIYSLIGSSHDLGENLIVLRNFYQSITKAAIALDSNLVGLVSEIIEPQFEALTIATVNERRLKNKIQSKSLA
Protein: Fasciclin domain family protein (AFU_orthologue AFUA_1G14300) (Q5BFB2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Transcription factor domain-containing protein
Sequence:
MKLQLHLTLAGLFCSVLAIQDVLSEVKDSRNGLLEAGAKNPLDSALELSPTFSPAEIFDTTEITKYLNSINVDTIPNTDSWISGFLASNLFNEITNAPSDFVNEIDARTETHPIQSDKTIYQLISESKYTNILAKIIDQDPKLVEFLNSTHHKITVFAPTDDAFRKILHHHHHRHHDGHDGNGHERDGDGDKDHHIPKEVIRYFASYHSSPEILTAAKLFHAHTVNSALNDSLLGTDKHDNGLPQRLAVRAGFKGLTINFYSHVVAADIGASNGLIHGLDSILLPPPPALLLLDILPTKFSTFNLGLIKTGLTQYLNTTKEESAHGFTIFTPSNRAFDHLGLRINAFLFSPYGIPYLRALLKYHIVPNQTLYSDVLYTSDGQIKPFGVKGSTHLDLETLLDDHEISVDVARFGPYTGFKVNGWQRVAFADVLGKDGVIHVLNRVLIPPKRVEGKVIFGDEGELELEEFMERLRPWVEEDVGNEKSDGYATDL
Protein: L-fucose-proton symporter (6-deoxy-L-galactose permease) (L-fucose permease) (L-fucose-H(+) symport protein) (P11551)
Organism: Escherichia coli (strain K12)
Function: Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose. Binds D-arabinose with the highest affinity, followed by L-fucose, and then by L-galactose.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:20877283}; Multi-pass membrane protein {ECO:0000269|PubMed:20877283}.
Interaction partners:
- L-fucose isomerase
- Lactose permease
- D-xylose-proton symporter
- Galactose-proton symporter
- Glycerol-3-phosphate transporter
- L-fuculokinase
- Inner membrane transport protein YajR
- L-fuculose phosphate aldolase
- L-fucose mutarotase
- Multidrug resistance protein D
Sequence:
MGNTSIQTQSYRAVDKDAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVPHQSQDVLDKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGNIPTAELIPALCFAVIFIFARFRSQTATN
Protein: Peptidoglycan hydrolase gp5 (Gene product 5) (Gp5) (P07582)
Organism: Pseudomonas phage phi6 (Bacteriophage phi-6)
Function: Muralytic enzyme exposed to host peptidoglycan layer after membrane fusion during viral entry. Functions as an exolysin that cleaves the peptide bridge formed by meso-diaminopimelic acid and D-alanine. Also lyses the host cell late in infection to release the virions.
Subcellular location: Virion. Note=Located between the capsid and the envelope.
Interaction partners:
Sequence:
MSKDSAFAVQYSLRALGQKVRADGVVGSETRAALDALPENQKKAIVELQALLPKAQSVGNNRVRFTTAEVDSAVARISQKIGVPASYYQFLIPIENFVVAGGFETTVSGSFRGLGQFNRQTWDRLRRLGRNLPAFEEGSAQLNASLYAIGFLYLENKRAYEASFKGRVFTHEIAYLYHNQGAPAAEQYLTSGRLVYPKQSEAAVAAVAAARNQHVKESWA
Protein: Protein DOM34 homolog (A0A1D8PSD0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU362019}.
Interaction partners:
- Ribosome dissociation factor GTPase
- Translation initiation factor RLI1
- Small ribosomal subunit protein RACK1
- SKI complex RNA helicase subunit
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS30
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS10
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MQVKNKAKLKDKNVAITLVPEDSEDLWYLYNLLKKGDTVQLVTHRNVKKGNQAQITKGKSKMEKIVVRLKLLVEDIDYIASDQTMRINGKSLVQQEYIPLNSFHTAEVELNKELTILKDNWDEYDMTLLNELCSIENKADIGAVVFQEGVAHICYVADSMTVLKAKVEKSIPRKNNEYGTRDLEKAMNSFFNMIISSMTRHFDFEKLKVVILASPGFLAKTLYDRLIQECLNLQNSGKESKVYSSILKNKSKFLIAHASTGYLQGLEEVLDDPQTKKRLADTKFLEESEALQRFQRALNDDDGRAWYGLEEITKALNMDAVRYLMVSDALFRSDDIEERRHYIDLTEQAKTLGAKVYIFSSLHESGEQLNQLTGIAALLKYPIPDLDDSDEED
Protein: Insulator binding factor 1, isoform B (A0A0B4LGV6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPRKKSEDFYRTHGFTANLENGKYSATCHFCEKVLQNTALSRLSLHRQTCDARRSRSAVVYTSADEKDHDEAPRIKIQKISGDDDGGLDNANEGKEIIVKIQQILDDADEAEAPKEQPRVKREIRKRKLTKTEESGEQNLEFEISNVEIKNPEYSEYLDESKEQNPDDLANGSATIIEARPRNGLAALRAEKARAEISQFQSKTKFLKTETDNLKVERTLTLLKIQKLRLEIDALRD
Protein: Ras-related protein Rab-1A (EC 3.6.5.2) (Q8I3W9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- GDP dissociation inhibitor, putative
- Rab GDP dissociation inhibitor
- Trafficking protein particle complex subunit 6A, putative
- Trafficking protein particle complex subunit 8, putative
- Trafficking protein particle complex subunit 2, putative
- Vacuolar protein sorting-associated protein 33, putative
- Rab-GAP TBC domain-containing protein
Sequence:
MTENRSRDYDYLYKIILIGDSGVGKSCILLRFSDDHFTESYITTIGVDFRFRTIKVDDKIVKLQIWDTAGQERFRTITSAYYRGADGIIIIYDTTDRNSFLHINDWMNEINKYTNEDTCKLLVGNKADCKDDIEITTMEGQNKAKELNISFIETSAKDATNVELAFTMITQELIKKKKKKNFTSLKNNHAKLKLSTHDNSPQSFCSC
Protein: Meiosis-specific transcription factor NDT80 (P38830)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:11035815}.
Interaction partners:
- Meiosis induction protein kinase IME2/SME1
- Suppressor of mar1-1 protein
- Meiosis-specific protein SPO11
- Meiotic recombination protein DMC1
- Synaptonemal complex protein ZIP1
- Meiosis-inducing protein 1
- Cell cycle serine/threonine-protein kinase CDC5/MSD2
- Probable DNA-binding protein SNT1
- SIR4-interacting protein SIF2
- Meiosis-specific serine/threonine-protein kinase MEK1
Sequence:
MNEMENTDPVLQDDLVSKYERELSTEQEEDTPVILTQLNEDGTTSNYFDKRKLKIAPRSTLQFKVGPPFELVRDYCPVVESHTGRTLDLRIIPRIDRGFDHIDEEWVGYKRNYFTLVSTFETANCDLDTFLKSSFDLLVEDSSVESRLRVQYFAIKIKAKNDDDDTEINLVQHTAKRDKGPQFCPSVCPLVPSPLPKHQIIREASNVRNITKMKKYDSTFYLHRDHVNYEEYGVDSLLFSYPEDSIQKVARYERVQFASSISVKKPSQQNKHFSLHVILGAVVDPDTFHGENPGIPYDELALKNGSKGMFVYLQEMKTPPLIIRGRSPSNYASSQRITVRTPSSVNSSQNSTKRKMPSMAQPLNESCLNARPSKRRSKVALGAPNSGASISPIKSRQSTPMEASKENEDPFFRPNKRVETLEHIQNKLGALKNQCPDSSLKYPSSSSRGMEGCLEKEDLVYSSSFSVNMKQIELKPARSFEHENIFKVGSLAFKKINELPHENYDITIEKKSMEQNYLRPEIGSRSECKTSYGNELSLSNISFSILPNSAENFHLETALFPATEEDVPRTFSRILETGSFQNYYQKMDAENADRVYSKGVKLIASGTLPSGIFNREELFEEDSFYKY
Protein: Two pore channel protein 2 (Two pore calcium channel protein 2) (Q8NHX9)
Organism: Homo sapiens (Human)
Function: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate). Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis. Is associated with a plethora of physiological processes, including mTOR-dependent nutrient sensing, skin pigmentation and autophagy. Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2. As calcium channel, it increases the pH in the lysosomal lumen, as sodium channel, it promotes lysosomal exocytosis. Plays a crucial role in endolysosomal trafficking in the endolysosomal degradation pathway and is potentially involved in the homeostatic control of many macromolecules and cell metabolites (By similarity). Also expressed in melanosomes of pigmented cells where mediates a Ca(2+) channel and/or PI(3,5)P2-activated melanosomal Na(+) channel to acidify pH and inhibit tyrosinase activity required for melanogenesis and pigmentation. Unlike the voltage-dependent TPCN1, TPCN2 is voltage independent and can be activated solely by PI(3,5)P2 binding. In contrast, PI(4,5)P2, PI(3,4)P2, PI(3)P and PI(5)P have no obvious effect on channel activation.
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:32167471}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:20880839, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:31825310, ECO:0000269|PubMed:32167471}; Multi-pass membrane protein {ECO:0000255}. Melanosome membrane {ECO:0000269|PubMed:27140606}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Two pore channel protein 1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- Sodium/potassium/calcium exchanger 4
- Sodium/potassium/calcium exchanger 5
- Glutamine-dependent NAD
- Membrane-associated transporter protein
- P protein
- Mucolipin-1
Sequence:
MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWLCR
Protein: T. brucei spp.-specific protein (Q388Q7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNQLSHKKDQSSNATDYKRGTLYLLFYIMRHVSSIFFFLLPFILSFSPPHFPLLFCQCVAQSGPALAVKKKQKVYGVAFFFFFVSTVLCPFYFSFFFPYLIMLIILYVPPQPFPLGSLEGVRKCDWVFKVLFFHSSLFVHSHLPLCVRAWEAYLKMGMI
Protein: Glycerol-3-phosphate acyltransferase (GPAT) (EC 2.3.1.15) (P0A7A7)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:16294310, ECO:0000269|PubMed:4943977}; Peripheral membrane protein {ECO:0000269|PubMed:16294310, ECO:0000269|PubMed:4943977}; Cytoplasmic side {ECO:0000269|PubMed:16294310, ECO:0000269|PubMed:4943977}.
Interaction partners:
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- Probable glycerol-3-phosphate acyltransferase
- Phosphate acyltransferase
- Glycerol-3-phosphate dehydrogenase [NAD
- Aerobic glycerol-3-phosphate dehydrogenase
- Glycerol kinase
- Acyl carrier protein
- Anaerobic glycerol-3-phosphate dehydrogenase subunit A
- CDP-diacylglycerol--serine O-phosphatidyltransferase PssA
- Anaerobic glycerol-3-phosphate dehydrogenase subunit B
Sequence:
MSGWPRIYYKLLNLPLSILVKSKSIPADPAPELGLDTSRPIMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGTLLPRYVFIHGGPRVFTYYTPKEESIKLFHDYLDLHRSNPNLDVQMVPVSVMFGRAPGREKGEVNPPLRMLNGVQKFFAVLWLGRDSFVRFSPSVSLRRMADEHGTDKTIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASRAIAKAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRLYQGINVHNAERVRQLAHDGHELVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLIPIYIGYEHVMEVGTYAKELRGATKEKESLPQMLRGLSKLRNLGQGYVNFGEPMPLMTYLNQHVPDWRESIDPIEAVRPAWLTPTVNNIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTEQLNCYLDLMRNVPYSTDSTVPSASASELIDHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLVLPSLMAAIVTQHRHISRDVLMEHVNVLYPMLKAELFLRWDRDELPDVIDALANEMQRQGLITLQDDELHINPAHSRTLQLLAAGARETLQRYAITFWLLSANPSINRGTLEKESRTVAQRLSVLHGINAPEFFDKAVFSSLVLTLRDEGYISDSGDAEPAETMKVYQLLAELITSDVRLTIESATQGEG
Protein: Ribonuclease E (RNase E) (EC 3.1.26.12) (A0R152)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Endoribonuclease that plays a central role in RNA processing and decay. Plays a major role in pre-16S rRNA maturation, probably generating the mature 5'-end, and a minor role in pre-5S and pre-23S rRNA maturation. Probably also processes tRNA (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:35521527}. Note=Has dynamic expression patterns, often present as foci near the mid-cell or new cell pole in addition to a weaker overall cytoplasmic distribution. Colocalizes with HupB (PubMed:35521527). {ECO:0000269|PubMed:35521527}.
Interaction partners:
- Polyribonucleotide nucleotidyltransferase
- Ribonuclease J
- Ribonuclease PH
- RNA helicase
- Ribonuclease 3
- ATP-dependent RNA helicase
- Transcription termination factor Rho
- Ribonuclease D
- Large ribosomal subunit protein bL21
- Oligoribonuclease
Sequence:
MAEDAHTEDLSTQTPQQEGLPERLRVHSLARVLGTTSRRVLDALAEFDGRQRSAHSTVDKADAERVRAALTESPAAETPPEEAPAAETPVADLVVVQAEQVEVVTVSEAGPAEPAEPAEPEAPAAEAEAEAETEVADEAETPEPTFRGAVLVGDEPESRLILEHANIPPARETQTERPDYLPLFVAPQPVSFEPAVVDDEDEDDDTETGAESDFDSGADSDSDDDQADRPRRRRRGRRGRGRGRGEQNDDATSDADTDSTEDQTDGDEQESGEDSDDSGDEDSTTTEGGTRRRRRRRRRKSGSGDSDDAVSPDDPPNTVVHERAPRTERSDKSDDSEIQGISGSTRLEAKRQRRRDGRDAGRRRPPILSEAEFLARREAVERTMIVRDKVRTEPPHEGARYTQIAVLEDGVVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYAGEVNWEAAGLGGQNRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLAGRYLVYVPGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGVKEEDIRSDVERLQKRWSEIEAKAAEVTEKKAGAAVALYEEPDVLVKVIRDLFNEDFSSLIVSGDEAWNTINSYVEAVAPDLMPRLTKYEPAGPDAPDVFAVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTGSGGNLEQTVTRNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTEALARDRTRHQVSEVTSLGLVQLTRKRLGTGLVEAFSTACTHCGGRGIVLHGDPIDSASSNGGRKSDSSGGGGSGGGRRGKRGKKGAARTEEVHVAKVPDHTPGEHPMFKAMAAANGKHEGDEDHEDHEDHETAEDTTAAEVRDDTRDEHDADERAHVVTAAVGAAGDEDLDDSDEDSDLDSDEESDDESDEDEIELDDDEDELDEDIEVIGDSDDSDDSDDSDEDDDSDDSDDDSDEDEDSDSDEDEEPVREVYEPPVTAPRARVRRRAAARPAGPPSHD
Protein: Tubulin polymerization-promoting protein homolog (TPPP) (Protein ringmaker) (Q9VV43)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulator of microtubule required for axonal extension during embryonic development. Promotes microtubule bundling and polymerization. Together with futsch, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:31156389}. Cell projection, axon {ECO:0000269|PubMed:27422099}. Presynapse {ECO:0000269|PubMed:31156389}. Note=Localizes at the presynaptic neuromuscular junction (NMJ). {ECO:0000269|PubMed:31156389}.
Interaction partners:
Sequence:
MSEVAAANGSPSPAPTPEVPATELAQLALEDEPKVSFSDQFKAFSKFGDSKSDGKLITLSQSDKWMKQAKVIDKKITTTDTGIHFKKFKAMKISLSDYNKFLDDLAKTKKVELSEIKQKLASCGAPGVVSVSAGKAAAAVDRLTDTSKYTGSHKERFDASGKGKGIAGRRNVVDGSGYVSGYQHKDTYDNAH
Protein: Abscisic acid receptor PYL3 (PYR1-like protein 10) (OsPYL10) (PYR1-like protein 3) (OsPYL3) (Regulatory components of ABA receptor 3) (Q6EN42)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in abscisic acid (ABA) signaling during seed germination and abiotic stress response. Acts as positive regulator of ABA-mediated inhibition of seed germination, and tolerance to drought and cold stresses. Together with PP2C50 and SAPK10, may form an ABA signaling module involved in stress response. Inhibits the protein phosphatases PP2C06 and PP2C09 when activated by abscisic acid (ABA).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:26362328}. Nucleus {ECO:0000269|PubMed:26362328}.
Interaction partners:
- Protein phosphatase 2C 50
- Probable protein phosphatase 2C 30
- Probable protein phosphatase 2C 6
- Probable protein phosphatase 2C 8
- Protein phosphatase 2C 51
- Protein phosphatase 2C 53
Sequence:
MVEVGGGAAEAAAGRRWRLADERCDLRAAETEYVRRFHRHEPRDHQCSSAVAKHIKAPVHLVWSLVRRFDQPQLFKPFVSRCEMKGNIEIGSVREVNVKSGLPATRSTERLELLDDNEHILSVRFVGGDHRLKNYSSILTVHPEVIDGRPGTLVIESFVVDVPEGNTKDETCYFVEALLKCNLKSLAEVSERLVVKDQTEPLDR
Protein: histidine kinase (EC 2.7.13.3) (A0A0H3C5M8)
Organism: Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Interaction partners:
Sequence:
MEFETLPDPFRRPAARAAGLDPAHAWRLGWLAAVCLAAAAALFTADSGGWPVWAALGAGALPALVSLIFTREDERTQSWLLVLWAVGGSLAAVLTGGVGGAMAAWCLAPVAAASTQDQPKRLAEGAALALIGACVAALTQLSGLAPAAPTGPLAFVLGFLALVTTGLGLAAGLLIGRRRQGARDDRYASEIIGLETLLDGLPHLAIAVRGQGQVTAVRGAAPPGVTRADLVNRGLTGAAAPGDRQRLTAAIAQAHREGSASLTFNPALGVERVVALDMHRVAPNQLVGVLRDITVERHREHALDQARIDAEALAAGRARFLANMSHELRTPLNAIMGFSDIMRARMFGPLSDRYAEYAELIHESGGHLLDLINDVLDMSKIEAERFELQRGVFDAREAVQAAMRLLRVQSDTAGVQLRGVLPPGELEVDADRRALKQIVLNLVSNALKFTPRGGQVTVTAHGYDGVLEIVVADTGVGISPEDLERLGRPYEQAGGAEQRARGTGLGLSLVRAFAQLHGGEMVIESRLGAGTTVSVRLPVLLAPMVAATPTPPAAPEAPSAPEPAPTVEEPPPASLGDNVIAFAPR
Protein: Pyrrolysine synthase (EC 1.4.1.-) (Pyrrolysine biosynthesis protein PylD) (Q8TUC1)
Organism: Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Function: Likely catalyzes the NAD(P)-dependent oxidative deamination of (3R)-3-methyl-D-ornithyl-N6-L-lysine, resulting in the formation of pyrrolysine after spontaneous dehydration and cyclization of the intermediate. Is required for the biosynthesis of pyrrolysine.
Interaction partners:
- 3-methyl-D-ornithine--L-lysine ligase
- 3-methylornithine synthase
- Pyrrolysine--tRNA ligase
- Monomethylamine methyltransferase MtmB1
- Trimethylamine methyltransferase MttB1
- Trimethylamine methyltransferase MttB2
- Methylamine methyltransferase corrinoid activation protein
- Monomethylamine methyltransferase MtmB2
Sequence:
MALLTPEDLENINRQLHEADSTVRRVTGLDIKGVCKDFYGTTPCCEKVGIVPVTSGNGIIGNFSESLRAITEYFGFDSFVTTMPDVSGYYEAVRNGAQIILMADDNTFLAHNLKNGKIANNQPCTGIIYAEIASRYMKADSKDVLAVGLGKVGFPGAAHLVNKGFRVYGYDADKALLEKTVSDLGITPFEPENPRRFSIIFEATPCADTVPESVISDNCVISTPGIPCAISRELQEKYGVELIMEPLGIGTASMLYSIL