wanglab/gogpt-training-data huggingface dataset:
Protein: Large ribosomal subunit protein eL30A (60S ribosomal protein L30-1) (L32) (P52808)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL6A
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein uL4A
Sequence:
MASVVTKKSKKSGDTINAKLALTMKSGKYVLGYKSTLKTLRSGKAKLILIAGNCPPLRKSELEYYAMLSKANVHHYAGTNIDLGTACGKLFRVGVLAITDAGDSDILDA
Protein: Tyramine beta-hydroxylase (EC 1.14.17.-) (Tyramine beta-monooxygenase) (TbetaM) (Q9XTQ6)
Organism: Caenorhabditis elegans
Function: Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity.
Subcellular location: [Isoform b]: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Chitinase-like protein C25A8.4
- Chitin-binding type-2 domain-containing protein
- DUF1525 domain-containing protein
- Peroxidase skpo-1
- Peptidase S1 domain-containing protein
- Aromatic-L-amino-acid decarboxylase
- Uncharacterized protein
- Tyrosine decarboxylase
- Aromatic-L-amino-acid decarboxylase
- Uterine Lumin Expressed/locailized
Sequence:
MEPTASQGIQYLRGGVEWILKLLNLHILNVKHENKPLLFRLIDLKVYIPSSVSTVRWSSGASSYVILGEYRKMRSAVALLFLLVAYCGGVVHAGEIVAELYHTNVTVKWHTDYERQLVDFSIWFGASTPDVLFLGFSDFGDTNNSDVLMYYNSKKEIKDAYTNRDFKITSDLQQDFQLLRKRKDHIVVRRKLTTCDSRDYAFLPGTTQFYIAASWGSTNLVDIRDKRWVVDKKFGKVIEGPTDQPNIEEEPAALEKDVKVVIVNSNSPDPIPNVETTYKCIIRKMPFDTVNNMYHVVRMEPYVTPGNEHLVHHMEIFMCRDEVEEWSGSCNDPKKPPKSKSCSHVIAAWAMGEGPIHYPKEAGLPIGGKGKNAYVMVEIHYNNPELHKGVIDSSGFQFFVTGQLRKYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTKNLPEEGINIFASQLHAHLTGRKLFTSQYRSGVRIGDVNRDEHYSPHWQHLQQLRPVVKVMPGDTLVTTCVYDTRKRSKVTFGGYRIVDEMCVNYIYYYPASDVEVCKSAISNSTLRAYFSERHGMDGKRMQISDMYSNVKDWGNGVDEEFYNVLNVGNMNMNCLKSNGEPFEFESKDSRQSWENMARPTFVSGSFITTRDRFQCPAINDMINFE
Protein: HSF-type DNA-binding domain-containing protein (K7LH36)
Organism: Glycine max (Soybean) (Glycine hispida)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNYMYQVKEEYLESSPSSSYQLGGEFPAKPIEGLHDTGPPPFLTKTFDVVDDPVTNHVVSWSRDGTSFVVWDPNTFSTSLLPRYFKHNNFSSFVRQLNTYGFRKIDPDKWEFANEGFIRGHRHLLRNIRRRKAPSQLTQGHHCVEVGRFDLDKEIDRLRHDKLVLLMELVNLRKQQQKARMYIQEMEQRLQGTEIKQKQMMAFLARAIKNPTFIHQLLQKEKSKELEEAFTKKRRQIEQGARGFGESSSVKVEALEFGESELEMLAREMQGFGKGGIDREVGPEALESQERLDRVLDEEFWEELLFSEKFEGRLDIPTAEDKDEDVIKVLANQLDLLDSSH
Protein: U6 snRNA-associated Sm-like protein LSm8 (P47093)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, spliceosomal U4/U6.U5 snRNP, and free U6 snRNP). It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved in degradation of nuclear pre-mRNA by targeting them for decapping. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. LSM2 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}. Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- LSM complex subunit LSM4
- Small nuclear ribonucleoprotein Sm D3
- Pre-mRNA-splicing factor SNU114
- LSM1-LSM7 complex subunit LSM1
- Pre-mRNA-processing factor 31
- LSM complex subunit LSM2
- 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component
- Small nuclear ribonucleoprotein Sm D2
- LSM complex subunit LSM7
- LSM complex subunit LSM6
Sequence:
MSATLKDYLNKRVVIIKVDGECLIASLNGFDKNTNLFITNVFNRISKEFICKAQLLRGSEIALVGLIDAENDDSLAPIDEKKVPMLKDTKNKIENEHVIWEKVYESKTK
Protein: LD46328p (Syndapin, isoform B) (Q9VDI1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSHHSDDQLLQAGSDSFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGPEYGTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLMQIKERKDLEDLFKKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQVQKCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSLPQIYEEFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSKEALPAAPITLINQRPVAEDVHEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSVTTSEAKTSAAVAGAATATAAATAASAASNRNSSVTNGNGKVDANPFDEEEEWDESDNVLVDNGEPGVPVKALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRMNGRVGLYPANYVETA
Protein: Set1 complex component sdc1 (Set1C component sdc1) (COMPASS component sdc1) (Complex proteins associated with set1 protein sdc1) (Lid2 complex component sdc1) (Lid2C component sdc1) (O74861)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Set1 complex component swd1
- Set1 complex component swd3
- Set1 complex component ash2
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- Set1 complex component spp1
- Set1 complex component swd2
- Set1 complex component shg1
- Lid2 complex component snt2
- Lid2 complex component lid2
- Lid2 complex component jmj3
Sequence:
MSNSAPARQYLNEKVTPVLLEGMKILARDRPENPLQFLGQFLLDANANQQKQKEIVNQPEPQQETPKADADMSTPTMAEQVQTSFSNPASTPLTQTSSPSSNPGKNSAS
Protein: 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) (A0A024RCV5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDLWPGAWMLLLLLFLLLLFLLPTLWFCSPSAKYFFKMAFYNGWILFLAVLAIPVCAVRGRNVENMKILRLMLLHIKYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVMSEVAQTLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQDFYCKKERRFTSGQCQVRVLPPVPTEGLTPDDVPALADRVRHSMLTVFREISTDGRGGGDYLKKPGGGG
Protein: Uncharacterized protein C29A10.09c (O94386)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Protein argonaute
- Protein Dicer
Sequence:
MEIHGKNFLETLKELEKHVDSAHYVSIDCEFSGLLRDFNLNNKNTLQDRYELLRKSSIRYTILQIGITFIYLQNNGKSSCIPVNINVSPLVKDELHLKRDFCSEASSIKFLIQQGFDFNKQLTEGVPYLSRIEERNLIDKVNERSTDDLTSSILDACDEEILVDARNQIKNWLSSELSHSTSKYLNITTSNRFIRKAIQSLVKIEFPTLKSYPKRTFLQVRKAIENSTTQCSATSKSELKEDIASDQLILNNLNLIKQNVGLRHLWDYILKKKKSVVCHNGMADLVYLFSLFEGKVPETILEFSELCLSSFKSIYDTKLLYLKSDDLQHVSDGIPTDLLSLVSKISLPPVPSNSSSQRSNVSLNSLIECPYKSMMSRKRPHEAGKDSYDTALLFVYYVMRTKHSDIQRWQNVLPIHGSFLDLNKYCS
Protein: Calcineurin B homologous protein 3 (Tescalcin) (TSC) (Q96BS2)
Organism: Homo sapiens (Human)
Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Subcellular location: Nucleus {ECO:0000269|PubMed:18321853}. Cytoplasm {ECO:0000269|PubMed:18321853}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:18321853}. Cell projection, lamellipodium {ECO:0000269|PubMed:11696366}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9JKL5}. Note=Colocalizes with SLC9A1 at the plasma membrane. {ECO:0000269|PubMed:18321853}.
Interaction partners:
- Sodium/hydrogen exchanger 1
Sequence:
MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPIDTTMDEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMGQMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
Protein: Phospholipase D zeta 2 (PLDzeta2) (EC 3.1.4.4) (Phospholipase D p2) (AtPLDp2) (Phospholipase D2 PHOX and PX-containing domain protein) (Q9M9W8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Phosphatidylcholine-selective. Regulates vesicle trafficking and auxin responses. Required for the normal cycling of PIN-2 containing vesicles. Contributes to the supply of inorganic phosphorus for cell metabolism and diacylglycerol moieties for galactolipid synthesis in phosphorus-starved roots. Involved in root elongation during phosphate limitation.
Interaction partners:
- CDP-diacylglycerol--serine O-phosphatidyltransferase 1
- Non-specific phospholipase C5
- Non-specific phospholipase C4
- Phosphatidate phosphatase PAH2
- Phosphatidate phosphatase PAH1
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- Non-specific phospholipase C1
- Non-specific phospholipase C2
- Non-specific phospholipase C6
- Monogalactosyldiacylglycerol synthase 3, chloroplastic
Sequence:
MSTDKLLLPNGVKSDGVIRMTRADAAAAAASSSLGGGSQIFDELPKAAIVSVSRPDTTDFSPLLLSYTLELQYKQFKWTLQKKASQVLYLHFALKKRLIIEELHDKQEQVREWLHSLGIFDMQGSVVQDDEEPDDGALPLHYTEDSIKNRNVPSRAALPIIRPTIGRSETVVDRGRTAMQGYLSLFLGNLDIVNSKEVCKFLEVSRLSFAREYGSKMKEGYVTVKHLRDVPGSDGVRCCLPTHCLGFFGTSWTKVWAVLKPGFLALLEDPFSGKLLDIMVFDTLGLQGTKESSEQPRLAEQVKEHNPLRFGFKVTSGDRTVRLRTTSSRKVKEWVKAVDEAGCYSPHRFGSFAPPRGLTSDGSQAQWFVDGHTAFEAIAFAIQNATSEIFMTGWWLCPELYLKRPFEDHPSLRLDALLETKAKQGVKIYILLYKEVQIALKINSLYSKKRLQNIHKNVKVLRYPDHLSSGIYLWSHHEKIVIVDYQVCFIGGLDLCFGRYDTAEHKIGDCPPYIWPGKDYYNPRESEPNSWEETMKDELDRRKYPRMPWHDVHCALWGPPCRDVARHFVQRWNHSKRNKAPNEQTIPLLMPHHHMVLPHYLGTREIDIIAAAKPEEDPDKPVVLARHDSFSSASPPQEIPLLLPQETDADFAGRGDLKLDSGARQDPGETSEESDLDEAVNDWWWQIGKQSDCRCQIIRSVSQWSAGTSQPEDSIHRAYCSLIQNAEHFIYIENQFFISGLEKEDTILNRVLEALYRRILKAHEENKCFRVVIVIPLLPGFQGGIDDFGAATVRALMHWQYRTISREGTSILDNLNALLGPKTQDYISFYGLRSYGRLFEDGPIATSQIYVHSKLMIVDDRIAVIGSSNINDRSLLGSRDSEIGVVIEDKEFVESSMNGMKWMAGKFSYSLRCSLWSEHLGLHAGEIQKIEDPIKDATYKDLWMATAKKNTDIYNQVFSCIPNEHIRSRAALRHNMALCKDKLGHTTIDLGIAPERLESCGSDSWEILKETRGNLVCFPLQFMCDQEDLRPGFNESEFYTAPQVFH
Protein: Activated in Blocked Unfolded protein response (Q23390)
Organism: Caenorhabditis elegans
Interaction partners:
- Activated in Blocked Unfolded protein response
- CC domain-containing protein
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Cuticlin 2
- Prion-like-
- Activated in Blocked Unfolded protein response
- Uncharacterized protein
Sequence:
MAARRAASILLIAVLALSSTFVFADEETVKNETGLALSRAKRQCCSSNSNSCCGNNNNVQCIPVCLQQCQSSCQTSQCIQQCQPACNQQCGGNNQVILLPQTNNCNQCQQQCISSCATPICAQSCNNQCSSSCGNSAPQIVVLQPQQNQCGSCQSSCQQTCPTCNCQSACAPACGGNNNNQQIIVVQQDNSCSSNCNNQCSSSCSTPICIQSCQSSCQQACQPTCQPQCMPSCSSSCTSNQAPIVIVAQQGDSCSNSCSNQCQSACPTPICVQQCNSQCQSQCSNSCSGNSCNQQQVIVLQQQDNCQNQCQSSCMNTCQSSATVLQCQPICQQTCQNTCQQAAQIVVPCQSSSSGCGCSSGYSQCGGSCCRRR
Protein: Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) (O88384)
Organism: Mus musculus (Mouse)
Function: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.
Subcellular location: Early endosome membrane {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9UEU0}. Lysosome membrane {ECO:0000250|UniProtKB:Q9UEU0}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9UEU0}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein {ECO:0000255}.
Interaction partners:
- Syntaxin-8
- Syntaxin-7
- Vesicle-associated membrane protein 8
- Syntaxin-6
- Vesicle-associated membrane protein 7
- Synaptobrevin homolog YKT6
- Syntaxin-16
- Clathrin interactor 1
- Vesicle-associated membrane protein 4
- Syntaxin-5
Sequence:
MAASAASSEHFEKLHEIFRGLLEDLQGVPERLLGTAGTEEKKKLVRDFDENQQEANETLAEMEEELRYAPLTFRNPMMSKLRNYRKDLAKLHREVRSTPLTAAPGGRGDLKYGTYTLENEHLNRLQSQRALLLQGTESLNRATQSIERSHRIATETDQIGTEIIEELGEQRDQLERTKSRLVNTNENLSKSRKILRSMSRKVITNKLLLSVIILLELAILVGLVYYKFFRHH
Protein: Plant UBX domain-containing protein 7 (PUX7) (Q94JZ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a bridge between CDC48A and ubiquitin, suggesting a role in targeted protein degradation.
Subcellular location: Nucleus {ECO:0000269|PubMed:23747397}.
Interaction partners:
- Plant UBX domain-containing protein 9
- Plant UBX domain-containing protein 13
- Plant UBX domain-containing protein 8
- Cell division control protein 48 homolog A
- Plant UBX domain-containing protein 1
- Plant UBX domain-containing protein 3
- Plant UBX domain-containing protein 5
- NPL4-like protein 1
- NPL4-like protein 2
- Plant UBX domain-containing protein 4
Sequence:
MEGMLSSGDQQRLVSSFLEIAVGQTAETARQFLQATSWKLEEAIQLFYIGNEGGMLQSGTHTQPASNDDAAAQSWGAATGTGNEMILPNDVDEVRAPLPVVRETLYGESMYYGAMRVGNSQPEPNSLIAFRNFSEEPKSPGIWEPDEGDSSASASASASASESASAPRDSLASLYRPPFHLMFQGSFEQAKTTSSSQDKWLLVNLQSTTEFSSHMLNRDTWANDAVSQTIKANFIFWQVYDDTTEGRKVCTYYKLESIPVVLVIDPTTGQRMRMWTGMVDPENLLEDLVPFMDGGPREHFASLSKKRPRGSFSLTPHSKPKEDVAKDEEEEELQRALAASLEDNNMKESSDDQSTIIPEEVAVEAVTSAVLPTFPPLPEEPKGGDRSLQCRVGIRLPNGQRLQRNFLKTDTIQLLWSFCYSQLEESERKKPLKLTQAIPGESKTLEYESNLTLEQSGVANSMISATWE
Protein: Protein DA1-related 2 (Protein LATERAL ROOT DEVELOPMENT 3) (Q0WSN2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts redundantly with DA1 and DAR1 to regulate endoreduplication during leaf development. Together with DA1 and DAR1, modulates the protein stability of the transcription factors TCP14 and TCP15, which repress endoreduplication by directly regulating the expression of cell-cycle genes. Involved in root phloem development. Is an essential component of early phloem development, long-distance delivery of phloem content, and proper maintenance of root system architecture. Involved in the control of root meristem size. Functions genetically downstream of cytokinin and IAA3 to maintain normal auxin distribution by influencing polar auxin transport. Acts through the PLETHORA pathway, upstream of PLT1 and PLT2 to influence root stem cell niche activity and thus control root meristem size.
Interaction partners:
- Transcription factor TCP14
- Leucine-rich repeat
- Transcription factor TCP15
- F20B24.22
- Probable E3 ubiquitin-protein ligase LUL2
- Protein GLUTAMINE DUMPER 2
- Probable E3 ubiquitin-protein ligase LOG2
- Dihydrofolate reductase
- LIM domain protein
- Protein GLUTAMINE DUMPER 1
Sequence:
MDSSSSSSSSSPSSSYGVARVSHISNPCIFGEVGSSSSSTYRDKKWKLMKWVSKLFKSGSNGGGSGAHTNHHPPQFQEDENMVFPLPPSSLDDRSRGARDKEELDRSISLSLADNTKRPHGYGWSMDNNRDFPRPFHGGLNPSSFIPPYEPSYQYRRRQRICGGCNSDIGSGNYLGCMGTFFHPECFRCHSCGYAITEHEFSLSGTKPYHKLCFKELTHPKCEVCHHFIPTNDAGLIEYRCHPFWNQKYCPSHEYDKTARCCSCERLESWDVRYYTLEDGRSLCLECMETAITDTGECQPLYHAIRDYYEGMYMKLDQQIPMLLVQREALNDAIVGEKNGYHHMPETRGLCLSEEQTVTSVLRRPRLGAHRLVGMRTQPQRLTRKCEVTAILVLYGLPRLLTGAILAHELMHGWLRLNGFRNLNPEVEEGICQVLSYMWLESEVLSDPSTRNLPSTSSVATSSSSSFSNKKGGKSNVEKKLGEFFKHQIAHDASPAYGGGFRAANAAACKYGLRRTLDHIRLTGTFPL
Protein: Protein hold'em (Q9W3M9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Single-stranded DNA-binding protein required for meiosis. May be involved in the resolution of recombination intermediates into crossovers in the meiotic recombination pathway.
Interaction partners:
- DNA repair endonuclease XPF
- Dehydrogenase/reductase SDR family protein 7-like
- DNA replication ATP-dependent helicase/nuclease
- Serine/threonine-protein kinase ATR
- Crossover junction endonuclease MUS81
- DEAD-box ATP-dependent DNA helicase Fancm
- GEO08380p1
- DNA replication licensing factor Mcm2
- DNA replication complex GINS protein SLD5
- Spindle assembly abnormal protein 6 homolog
Sequence:
MARRIKFQRLAEMRPTMTRFSTVALIVSKSSPNIFYDKMSGTERGVLSLTIRDSPNHLTNCKCWGQRDCVDEYAAMLQIGHVVDIVGAKVMSIPFAAPGEQRYQPQATVSCALVVNEGSGYVVRHDNDDFGQITILQQLLHQPIRPLGAVLKLADVRSGLGFPDKIITTNVNLLVVVAAVRPVRQIKRKLQGPLSEVQELLQCLEVIVIDASYPEGMLLSVWQPDWIQRAQQWQPRRTVLHLIDVRVSYSNFHRSLVLSHSNCTLICENPQAAGDDCRLLLAFAATVPLTTFSGCDQAELDNMPAVASIQAQMTVRQIYSRAEGELQDPSIHQFTAVLYGMVTKFDLDGLTSHVNRKCIACQQHIPRNLQDCASDACQQYFSLDNDEPRSISYFNINIHLSDQTGTLVEARLAGHPAERILGLRAEDFERLAEREKSELKWRFLLKYFEVRLMIKKPVGVRNHLVIVVVDMQAIPLEKLVANMVVF
Protein: Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) (P00920)
Organism: Mus musculus (Mouse)
Function: Catalyzes the reversible hydration of carbon dioxide (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation (By similarity). Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P00918}. Cell membrane {ECO:0000250|UniProtKB:P00918}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. {ECO:0000250|UniProtKB:P00918}.
Interaction partners:
- Sodium/hydrogen exchanger 1
- Band 3 anion transport protein
- Electrogenic sodium bicarbonate cotransporter 1
- Carbonic anhydrase 1
- Monocarboxylate transporter 1
- Sodium bicarbonate cotransporter 3
- Cathepsin K
- Chloride anion exchanger
Sequence:
MSHHWGYSKHNGPENWHKDFPIANGDRQSPVDIDTATAQHDPALQPLLISYDKAASKSIVNNGHSFNVEFDDSQDNAVLKGGPLSDSYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKIGPASQGLQKVLEALHSIKTKGKRAAFANFDPCSLLPGNLDYWTYPGSLTTPPLLECVTWIVLREPITVSSEQMSHFRTLNFNEEGDAEEAMVDNWRPAQPLKNRKIKASFK
Protein: Forkhead box protein J1 (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4) (Q61660)
Organism: Mus musculus (Mouse)
Function: Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung.
Subcellular location: Nucleus {ECO:0000305|PubMed:9096351}.
Interaction partners:
- DNA-binding protein RFX2
- Transcription factor RFX3
- Uteroglobin
- Secretoglobin family 3A member 2
- Surfactant protein C
- Multicilin
- Tektin-1
- Mucin-2
- Geminin coiled-coil domain-containing protein 1
Sequence:
MAESWLRLCGAGPGEEAGPEGGMEEPDALDDSLTSLQWLQEFSILNAKAPTLPPGGTDPHGYHQVPGLVAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQASQEPSAAPWGGPLTVNREAQQLLQEFEEATGEGGWGTGEGRLGHKRKQPLPKRVAKVLRPPSTLLLTQEEQGELEPLKGNFDWEAIFEAGALGEELSSLEGLELSPPLSPSSHGDVDLTVHGRHINCPATWGPPAEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPIFEAGDATLAADLQDWASVGAFL
Protein: RE07981p (Q8MS47)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MATEQHHQQRVLKQDGYLDLGDCNSAPSRPFEMRNVVYHPQLNVLLLFDNGSTVKVLDANSGVILQTYHLSSNGDSIVHGRYMPLQDKILFWDGHNLGLRGDYNGVLLLDTILQAPIGQNDDYIKLEIILSEAIIFQNCITELESEGLECPCDISNELTQKINQAQLKAKKGIKAQRWNTICLEVPYSSLKLVSNNMVILLKRLERHIPVLAIASAINERLTDMMMGSRVPDFGWNFSNFQRVLMHSEAVRRQTFEKWPHMDYKWALPDQMAQAGFYHQPSSSGEDRAMCFTCSVCLVCWEKTDEPWSEHERHSPLCPFVKGEYTQNVPLSITYATNPALPAPGLGFDIISNSDYANVLCTSCSQTGELSVWSIERHLKLMHTFHVPTLLNYIFEESFEWARVTAICVLPNARARTKVNYVYSAANYGGSGSSNGAGCNSGLNAVSGGKFGSVSAQHITSTSTLRAGVVGSKIVLGVSVRQSSGELALRMVVLNIVEVDRNSESSTSVSNDSGSVSSGGGQLMKSSSPMVNVSAESNATVTQVNLESKDDDNKAMTPYEKFADGFDSNGFVSALMTYNKNNGVSQNTDDASALYDFDLCTLSQILDHNLEEPLSLMVGSSNTVNVSNIGMGNEINKLVVDVEISHQNNNNNNNNNNEASSLGGNSSNNNNNIMINGGTNSSIDKMTAIEEIDCVVESWTSVKRMNALDGASSGVNGVNHMDQEVIEIAEILPTTPKCNQLLVKLLRTKAPEAEGSKIIMATVAKEEEEEDEEQRTDESMETDNNAEGNVAAQLLVFDYDDTEISNDYTLAMTFSRAKFPKQLCILPHFNSSPEHKDAGSICVVCADGTVEIYSLADFQGTMVIEEEGEHFESVVYCRNLDRLCCCSRQGGLLFYSLSDGENDSGDELLEMDDDCSTTLTQAADVSVTDGGRQLARTDLLGKTLLANESICMDAGSEAAAIPNSSSAAQGAHVQTSPSASSAPSTNANLLAYKTADLTLEDLKVFYALTQFDDKLTVYSAEVPSCWNDIGQVQNQRKQSQNMRHGGDERDFTRTWRLHNDATTWDEHIIELNLAQPVSLGHIDLKFTVYQQCSNPAAIQVTLLKQNNNGFGYRMKGPHSSYKPNVIDDNIDLSYIANENPVLSEEYLQKKKK
Protein: Macrocin-O-methyltransferase domain-containing protein (Q38A36)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFFLTRFKLGMADVTAAIGSGKCGEVLRKLNEKKAVREREENIDYRRALCFLANSQDVFHARQALLEELRHFPNNTAARTLLLEVNETVRPLLMPPKELLKSEPLFGLLCDALLDHTMLTWTRLYSLYRLSKEVCSKEGEGGALMECGVSGGGSVVLLAVVAAHYSKKPRKIYALDTFSGMPEPTTHDNLEEDGNLKPAESTSWGSGTCSATVENVRQLAKNFDVEEGLVVIPGLFHETMPKTLREISDEGISMLHVDADWYESTRCALELAWPMVKQGGMVQVDDYHYWLGCRKAVDEFAQREESEHRPLPILQNVDGNAVYFTKP
Protein: Paired mesoderm homeobox protein 1 (Homeobox protein K-2) (Muscle homeobox protein) (MHox) (Paired-related homeobox protein 1) (PRX-1) (P63013)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer.
Subcellular location: Nucleus {ECO:0000269|PubMed:35589735}.
Interaction partners:
- Twist-related protein 1
Sequence:
MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQVPTVN
Protein: Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC 1.1.1.8) (Q57YW0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Dihydroxyacetone phosphate acyltransferase, putative
- Glycerol-3-phosphate dehydrogenase
- Glycerol-3-phosphate dehydrogenase
- Glycerol-3-phosphate acyltransferase, putative
- Phosphatidic acid phosphatase protein, putative
- Phosphatidic acid phosphatase, putative
- Lipin, putative
- Phosphatidic acid phosphatase alpha, putative
- Glucose-6-phosphate isomerase
- ATP-dependent 6-phosphofructokinase
Sequence:
MVSGVTYLKRGAVFGSGAFGTALACVLAKKCESVSVWHMNANEARVVNQKHENVYFLPGAPLPANLTFTADAEECAKGAEIVLFVIPTQFLRGFLQKNSHILRNHVVSRNVPVVMCSKGIERSSLLFPAQILEEFLPNYPIGVIAGPSFAIEVAKGMLTNVCTAAADINMARKIQKIMTTSDGSFRCWATTDVIGCEIASAMKNVLAIASGALKGLGTENNARAALISRGLLEIRDLTLALGGTGEAVFGLPGLGDLLLTCSSELSRNFTVGMKLGQGISLEEIKRTSKAVAEGVATAEPLERLAKKHNVHLPICHEVYNVLYANGCAKRSFKKLNSCKLADEGLPALPRTSKM
Protein: AREA (Q00171)
Organism: Emericella nidulans (Aspergillus nidulans)
Interaction partners:
Sequence:
MSGLTLGGGSGRVRPTQAAAAFPTSHDFADPDRSSVARNANRPSRRFAAPPQLSDDFSLESPTDSAQVHDNLLQDALFPEWKGNSPRGVDSPDEMQKKDPLATQIWKLYSRTKAQLPNQERMENLTWRMMALSLRRQERERAQQQARASSQKSPVPGM