wanglab/gogpt-training-data huggingface dataset:
Protein: Golgi brefeldin A resistant guanine nucleotide exchange factor 1 (A0A669KB10)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
Interaction partners:
Sequence:
MVDKNIYIIQGEINIVVGAIKRNARWSTHTPLDEERDPLLHSFGHLKEVLNSITELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKNYVGTNMKKISPCLLNKLELSSGEQTKALNQLERLKMRAGGMSDSSKWKKQKRSPRPPRHMTKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASAVVSPSTDSGLEFSSQTTSKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQEGTHVEKSQSASVESIPEVLEECTSPADHSDSASVHDMDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQLLSIERLNLYAASLRVCFLLFESMREHLKFQMEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEELTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDGTREASNTERTASDGKAVGMASDIPGLHLPGGGRLPPEHGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRKNIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWNVLLHRGATPEGIFLRVPTASYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALECIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLLRLAIRLLRREEISAQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPPAALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADVVNSGWLVVGKDDVDNSKPGPSRPGPSPLINQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQEKRGKSHKYDSKGNRFKKKSKEGSMLRRPRTSSQHASRGGQSDDDEDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGQKIEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRASTLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELFKQTVIQDPMPMEPQGQKPLASAHLTSAAGDTRTPGHPPPPEIPSELGACDFEKPESPRAASSSSPGSPVASSPSRLSPTPDGPPPLAQPPLILQPLASPLQVGVPPMTLPIILNPALIEATSPVPLLATPRPTDPIPTSEVN
Protein: Antihemorrhagic factor BJ46a (Metalloproteinase inhibitor) (Q9DGI0)
Organism: Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Function: Potent inhibitor of hemorrhagic activity but also proteolytic activities of atrolysin C and jararhagin. Inhibition occurs by formation of a non-covalent complex between BJ46a and the proteinases at their metalloproteinase domains.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MNSLVALVLLGQIIGSTLSSQVRGDLECDEKDAKEWTDTGVRYINEHKLHGYKYALNVIKNIVVVPWDGDWVAVFLKLNLLETECHVLDPTPVKNCTVRPQHNHAVEMDCDVKIMFNVDTFKEDVFAKCHSTPDSVENVRRNCPKCPILLPSNNPQVVDSVEYVLNKHNEKLSDHVYEVLEISRGQHKYEPEAYYVEFAIVEVNCTAQELHDDHHHCHPNTAGEDHIGFCRATVFRSHASLEKPKDEQFESDCVILHVKEGHAHSHLIQQHVEKDSISPEHNNTALNFVHPHNDTSTSHESHEHLAEVPVAFVKKELPKDISDRHTTPVKGCPGKVHHFEL
Protein: Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase) (Q924Y0)
Organism: Mus musculus (Mouse)
Function: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- 4-trimethylaminobutyraldehyde dehydrogenase
- Alpha-aminoadipic semialdehyde dehydrogenase
- Aldehyde dehydrogenase, mitochondrial
- Aldehyde dehydrogenase family 3 member A2
- Aldehyde dehydrogenase X, mitochondrial
Sequence:
MHCAILKAEAVDGAHLMQIFWHDGAESLYPAVWLRDNCQCSDCYLHSAKARKLLLEALDVNIRIDDLTFDRKKVYITWPNDHYSEFEANWLKKRCFSQQARARLQGELFLPECQYWGSELQLPTLNFEDVLNDDDHAYKWLSSLKKVGIVRLTGAADKRGEIIKLGKRIGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKEKNPQAFHILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRVNFNNATRDTVFDVPIERVQPFYAALKEFVDLMNSKEYKYTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVTNGN
Protein: BTB/POZ domain-containing protein 16 (Q32M84)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MIMSNTHKARLERRVTGSTNRWRLPKQPFSGDLLSLSQMCKALSIDFEEALRNPDRLCISQIQKFFFENFKNKDIQSGEADVILECLGFKWELHQPQLFQSETLAKLYLKALAQGTTHPLRELEELLRAQSPKKTKEKSPAKRIIISLKINDPLVTKVAFATALKNLYMSEVEINLEDLLGVLASAHILQFSGLFQRCVDVMIARLKPSTIKKFYEAGCKYKEEQLTTGCEKWLEMNLVPLGGTQIHLHKIPQDLLHKVLKSPRLFTFSEFHLLKTMLLWVFLQLNYKIQAIPTYETVMTFFKSFPENCCFLDRDIGRSLRPLFLCLRLHGITKGKDLEVLRHLNFFPESWLDQVTVNHYHALENGGDMVHLKDLNTQAVRFGLLFNQENTTYSKTIALYGFFFKIKGLKHDTTSYSFYMQRIKHTDLESPSAVYEHNHVSLRAARLVKYEIRAEALVDGKWQEFRTNQIKQKFGLTTSSCKSHTLKIQTVGIPIYVSFAFIFPAS
Protein: Phosphate transporter (Q9XZE4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
Sequence:
MFSSFFETARNSPFRTPMSMARCDAAAPVVEPQPVEGRQIAAAATPVANQQDSCEFGSTKYFALCGIGGILSCGTTHTFVVPLDLVKCRLQVDQAKYKNLVHGFKVTVAEEGARGLAKGWFPTLLGYSAQGLCKFGLYELFKVKYAEIIGEENAYLYRTSLYLAASASAEFFADIVLAPFEAAKVKIQTIPGYANNFREAVPKMLKEEGVNAFYKGLVPLWMRQIPYTMMKFACFERTVELLYKYVVPKPRADCTKGEQLIVTFAAGYIAGVFCAVVSHPADVVVSKLNQAKGASAISVAKSLGFSGMWNGLTPRIIMIGTLTALQWFIYDGVKVALGIPRPPPPEMPASLKAKQH
Protein: Syntenin-1 (Scaffold protein Pbp1) (Syndecan-binding protein 1) (O08992)
Organism: Mus musculus (Mouse)
Function: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (By similarity). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (By similarity).
Subcellular location: Cell junction, focal adhesion {ECO:0000250|UniProtKB:O00560}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O00560}. Cell membrane {ECO:0000250|UniProtKB:O00560}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00560}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00560}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00560}. Nucleus {ECO:0000250|UniProtKB:O00560}. Melanosome {ECO:0000250|UniProtKB:O00560}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O00560}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O00560}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:O00560}. Membrane raft {ECO:0000250|UniProtKB:O00560}. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (By similarity). {ECO:0000250|UniProtKB:O00560}.
Interaction partners:
- Programmed cell death 6-interacting protein
- CD63 antigen
- Neurofascin
- Syndecan-4
- Syndecan-1
- CD9 antigen
- CD81 antigen
- Cell adhesion molecule 1
- Tumor susceptibility gene 101 protein
- Epidermal growth factor receptor
Sequence:
MSLYPSLEDLKVDKVIQAQTAYSANPASQAFVLVDASAALPPDGNLYPKLYPELSQYMGLSLNEAEICESMPMVSGAPAQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEINGQNVIGLKDAQIADILSTAGTVVTITIMPTFIFEHIIKRMAPSIMKSLMDHTIPEV
Protein: U3 small nucleolar RNA-associated protein MPP10 (U3 snoRNA-associated protein MPP10) (M phase phosphoprotein 10) (P47083)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12068309, ECO:0000269|PubMed:9315638}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 22
- Probable ATP-dependent RNA helicase DHR1
- Nucleolar complex protein 4
- U3 small nucleolar RNA-associated protein 21
- Protein BFR2
- U3 small nucleolar ribonucleoprotein protein IMP3
- U3 small nucleolar RNA-associated protein 15
- rRNA biogenesis protein RRP5
- Nucleolar protein 56
- Ribosome biogenesis protein BMS1
Sequence:
MSELFGVLKSNAGRIILKDPSATSKDVKAYIDSVINTCKNGSITKKAELDEITVDGLDANQVWWQVKLVLDSIDGDLIQGIQELKDVVTPSHNLSDGSTLNSSSGEESELEEAESVFKEKQMLSADVSEIEEQSNDSLSENDEEPSMDDEKTSAEAAREEFAEEKRISSGQDERHSSPDPYGINDKFFDLEKFNRDTLAAEDSNEASEGSEDEDIDYFQDMPSDDEEEEAIYYEDFFDKPTKEPVKKHSDVKDPKEDEELDEEEHDSAMDKVKLDLFADEEDEPNAEGVGEASDKNLSSFEKQQIEIRKQIEQLENEAVAEKKWSLKGEVKAKDRPEDALLTEELEFDRTAKPVPVITSEVTESLEDMIRRRIQDSNFDDLQRRTLLDITRKSQRPQFELSDVKSSKSLAEIYEDDYTRAEDESALSEELQKAHSEISELYANLVYKLDVLSSVHFVPKPASTSLEIRVETPTISMEDAQPLYMSNASSLAPQEIYNVGKAEKDGEIRLKNGVAMSKEELTREDKNRLRRALKRKRSKANLPNVNKRSKRNDVVDTLSKAKNITVINQKGEKKDVSGKTKKSRSGPDSTNIKL
Protein: Methionine aminotransferase (EC 2.6.1.88) (Methionine-oxo-acid transaminase) (P77806)
Organism: Escherichia coli (strain K12)
Function: Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- HTH-type transcriptional regulator MetR
- Hydroxycarboxylate dehydrogenase A
- Cystathionine gamma-synthase
- 5,10-methylenetetrahydrofolate reductase
- Bifunctional aspartokinase/homoserine dehydrogenase 2
- Homoserine O-succinyltransferase
- Bifunctional chorismate mutase/prephenate dehydratase
- Cystathionine beta-lyase MetC
- Probable S-methylmethionine permease
- Uncharacterized protein YbdM
Sequence:
MTNNPLIPQSKLPQLGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAHHVAQGANQYAPMTGVQALREAIAQKTERLYGYQPDADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYAPAIALSGGIVKRMALQPPHFRVDWQEFAALLSERTRLVILNTPHNPSATVWQQADFAALWQAIAGHEIFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVAPAPISAEIRKVHQYLTFSVNTPAQLALADMLRAEPEHYLALPDFYRQKRDILVNALNESRLEILPCEGTYFLLVDYSAVSTLDDVEFCQWLTQEHGVAAIPLSVFCADPFPHKLIRLCFAKKESTLLAAAERLRQL
Protein: CDPK-related kinase 3 (AtCRK3) (EC 2.7.11.1) (Calcium/calmodulin-dependent protein kinase 4) (AtCK) (Q9ZUZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger (By similarity). Serine/threonine kinase that phosphorylates histone H3 an GLN1-1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16472779}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Cysteine-rich receptor-like protein kinase 1
- Cysteine-rich receptor-like protein kinase 21
- Putative cysteine-rich receptor-like protein kinase 16
- Cysteine-rich receptor-like protein kinase 41
- Cysteine-rich receptor-like protein kinase 46
- AP-3 complex subunit sigma
- Early nodulin-like protein 12
- Putative cysteine-rich receptor-like protein kinase 9
- Probable mediator of RNA polymerase II transcription subunit 26b
- Cysteine-rich receptor-like protein kinase 4
Sequence:
MGQCYGKVNQSKQNGEEEANTTTYVVSGDGNQIQPLTPVNYGRAKNTPARSSNPSPWPSPFPHGSASPLPSGVSPSPARTSTPRRFFRRPFPPPSPAKHIKASLIKRLGVKPKEGPIPEERGTEPEQSLDKSFGYGKNFGAKYELGKEVGRGHFGHTCSGRGKKGDIKDHPIAVKIISKAKMTTAIAIEDVRREVKLLKSLSGHKYLIKYYDACEDANNVYIVMELCDGGELLDRILARGGKYPEDDAKAIVVQILTVVSFCHLQGVVHRDLKPENFLFTSSREDSDLKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSLEADIWSIGVITYILLCGSRPFWARTESGIFRTVLRTEPNYDDVPWPSCSSEGKDFVKRLLNKDYRKRMSAVQALTHPWLRDDSRVIPLDILIYKLVKAYLHATPLRRAALKALAKALTENELVYLRAQFMLLGPNKDGSVSLENFKTALMQNATDAMRESRVPEILHTMESLAYRKMYFEEFCAAAISIHQLEAVDAWEEIATAGFQHFETEGNRVITIEELARELNVGASAYGHLRDWVRSSDGKLSYLGFTKFLHGVTLRAAHARPR
Protein: Ribosome assembly protein 4 (Notchless protein homolog 1) (Ribosome biogenesis factor RSA4) (P25382)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin (MDN1/REA1), which is essential for the ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16221974}.
Interaction partners:
- Nuclear GTP-binding protein NUG1
- Nucleolar GTP-binding protein 2
- Probable metalloprotease ARX1
- Ribosome biogenesis protein NSA2
- Ribosome biogenesis protein NOP53
- Midasin
- Pre-rRNA-processing protein IPI3
- Nucleolar GTP-binding protein 1
- Protein SDA1
- Pre-rRNA-processing protein RIX1
Sequence:
MSTLIPPPSKKQKKEAQLPREVAIIPKDLPNVSIKFQALDTGDNVGGALRVPGAISEKQLEELLNQLNGTSDDPVPYTFSCTIQGKKASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLWTH
Protein: Bone morphogenetic protein 5 (Q7T288)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRTFGLLWSCLGFLHGVQCGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTTEEENAILGKSLAGKVRKSAPGAPHGYSRAPPRVPQPQHSRAAPLSSQSPPLANAHDTNFLNDADMVMSFVNLVERDKDFSHHRRHYREFRFDLTQIPEGEAVTAAEFRIYKDQSHIRYENITLKVTIYQVIKEYPNRDPDTFLLDWKKIRATDGGWLVFDITATSNHWVLNPQQNMGLQLCVETTDGRSINMKSAGIIGRNGPQSKQPFLVAFFKASEVLLRSVRATGSKKKSHNRNKSKTQVKSTPALKSGDQNTSEQRQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDNVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
Protein: EPH receptor B2 (EPHB2 protein) (Q6NVW1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKMKTQRS
Protein: Aromatic aminotransferase ISS1 (EC 2.6.1.27) (EC 2.6.1.5) (EC 2.6.1.88) (Methionine aminotransferase ISS1) (Phenylalanine aminotransferase ISS1) (Protein INDOLE SEVERE SENSITIVE 1) (Protein REVERSAL OF SAV3 PHENOTYPE 1) (Tryptophan aminotransferase ISS1) (Tyrosine aminotransferase ISS1) (Q9C969)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Coordinates and prevents auxin (IAA) and ethylene biosynthesis, thus regulating auxin homeostasis in young seedlings. Shows aminotransferase activity with methionine; can use the ethylene biosynthetic intermediate L-methionine (L-Met) as an amino donor and the auxin biosynthetic intermediate, indole-3-pyruvic acid (3-IPA) as an amino acceptor to produce L-tryptophan (L-Trp) and 2-oxo-4-methylthiobutyric acid (KMBA). Can also use tryptophan (Trp), phenylalanine (Phe), and tyrosine (Tyr) as substrates. Regulates tryptophan (Trp) homeostasis and catabolism in mature plants. Also possibly involved in the metabolism of other aromatic amino acids and phenylpropanoid homeostasis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23377040}.
Interaction partners:
- L-tryptophan--pyruvate aminotransferase 1
- Probable indole-3-pyruvate monooxygenase YUCCA1
- Tryptophan aminotransferase-related protein 2
- Acireductone dioxygenase 1-requiring) 1)
- S-adenosylmethionine synthase 1
- Acireductone dioxygenase 2-requiring) 2)
- Acireductone dioxygenase 4-requiring) 4)
- Acireductone dioxygenase 3-requiring) 3)
- S-adenosylmethionine synthase 3
- S-adenosylmethionine synthase 2
Sequence:
MGSFGMLSRRTLGTDMPVMAQIRSLMAELTNPMSLAQGVVHWQPPQKALEKVKELVWDPIISSYGPDEGLPELRQALLKKLREENKLTNSQVMVTAGANQAFVNLVITLCDAGDSVVMFEPYYFNSYMAFQMTGVTNIIVGPGQSDTLYPDADWLERTLSESKPTPKVVTVVNPGNPSGTYVPEPLLKRIAQICKDAGCWLIVDNTYEYFMYDGLKHCCVEGDHIVNVFSFSKTYGMMGWRLGYIAYSERLDGFATELVKIQDNIPICAAIISQRLAVYALEEGSGWITERVKSLVKNRDIVKEALEPLGKENVKGGEGAIYLWAKLPEGHRDDFKVVRWLAHRHGVVVIPGCASGSPGYLRVSFGGLQEVEMRAAAARLRKGIEELLHHGMVE
Protein: mannose-6-phosphate isomerase (EC 5.3.1.8) (O51368)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
- protein-N
- Glucose-6-phosphate isomerase
- Pts system, fructose-specific iiabc component
- Glucosamine-6-phosphate deaminase
- ATP-dependent 6-phosphofructokinase
- Phosphomannomutase
- Pts system, iibc components
- Pts system, maltose and glucose-specific iiabc component
- Glucose-6-phosphate 1-dehydrogenase
Sequence:
MNNEDNIFLMKNNIKEYDWGGINFIPNLLGDKIDGKPKAEMWLGAHKTFSSKILYKNEYVLLSDFLEDHKELLGCNDEFPFLLKVLSANKPLSIQIHPSKDIALKGYESENNKGIDINDPKRTYKDKNPKIELIYALSDFYALKGFLPLDEIKKIYEILELNFDFQSHKDFVKTIFDLQMYELEKIIEKILKNLDLIDNFRGYWFNEIYNIYGIDVGLLVFLGMNILKLKPGEVVYTNSQEVHAYLKGDCIELMTNSDNVIRAGLTTKYIDKDEMLRVGQFEEGKLSFLNPDFQDNFSVFRLPNTNLKLIQKKINENICINRNSAMVLLVLNGCVSINKSLNLKKGESIFIGKKAENLFIDGDGEAFIAGFN
Protein: Ferric uptake regulation protein (Ferric uptake regulator) (P54574)
Organism: Bacillus subtilis (strain 168)
Function: Iron uptake repressor. Acts on the transcription of ferri-siderophore uptake genes.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Manganese transport system membrane protein MntC
- Tyrosine recombinase XerD
Sequence:
MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVYLLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCMECGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE
Protein: Mlc titration factor A (Mlc-binding protein) (Probable zinc metallopeptidase MtfA) (EC 3.4.11.-) (P76346)
Organism: Escherichia coli (strain K12)
Function: Involved in the regulation of ptsG expression by binding and inactivating Mlc.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01593, ECO:0000269|PubMed:16855233}.
Interaction partners:
- DNA-binding transcriptional repressor Mlc
Sequence:
MIKWPWKVQESAHQTALPWQEALSIPLLTCLTEQEQSKLVTLAERFLQQKRLVPLQGFELDSLRSCRIALLFCLPVLELGLEWLDGFHEVLIYPAPFVVDDEWEDDIGLVHNQRIVQSGQSWQQGPIVLNWLDIQDSFDASGFNLIIHEVAHKLDTRNGDRASGVPFIPLREVAGWEHDLHAAMNNIQEEIELVGENAASIDAYAASDPAECFAVLSEYFFSAPELFAPRFPSLWQRFCQFYQQDPLQRLHHANDTDSFSATNVH
Protein: Mitochondrial import inner membrane translocase subunit TIM50 (Q586S5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU365079}; Single-pass membrane protein {ECO:0000256|RuleBase:RU365079}.
Interaction partners:
Sequence:
MYGRCLHRLSRSAPGVLGRQWQSAFPQGTSTKGGTNTDAHIFTRSASPIHMYANKENAWKDYTDDRFYGAKRMKEYWVRMMYDRGARYYVLATLVAIMLAGSKLWSLQEKQKRLLGLIGPKKKNYRSRLTVVLDVDETIVSYGDKAFRMKAGLVPRPYLAELLDYLSFIDAEVVLWSACSERYMQQVLNVIDPSGIRVSQCIVRNRDWFTGDNYYEKNILWLKRPLEDTLIVENRPLSVRNCNANAILVDDFIRAEYMDTGKDYPSNDNALRTLKAIIQDLHESGLPVKEYLADAKRRNKDIKEIPCHLAFRQLPDELARGVFYFIGEKYKHSSAS
Protein: Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (Q9D658)
Organism: Mus musculus (Mouse)
Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Subcellular location: Cell membrane. Early endosome.
Interaction partners:
- Metal transporter CNNM3
Sequence:
MARMNRPAPVEVSYRHMRFLITHNPSNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLLKAKFYNDPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
Protein: AP complex subunit sigma (B8ZZZ1)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00029433}.
Interaction partners:
Sequence:
MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNEFNCWFLLMRLLSVLDSWSTPALNSEVPQLATITPDFCLF
Protein: Polyadenylate-binding protein (PABP) (A3KFU8)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU362004}.
Interaction partners:
Sequence:
MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVMKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDGNLKELFSQFGKTLSVKVMRDSSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKAIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRREFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPASAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSALRQSGPRPALRHLAPTGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVPNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGTVAAATS
Protein: CUB-like domain-containing protein (O02360)
Organism: Caenorhabditis elegans
Interaction partners:
- DAF-16/FOXO Controlled, germline Tumor affecting
- IgGFc_binding domain-containing protein
- IgGFc-binding protein-like
- CUB-like domain-containing protein
- CUB-like domain-containing protein
- CUB-like domain-containing protein
- CUB-like domain-containing protein
Sequence:
MSARFVAFLLITSNLIILSKTDDDFTCPTIHITKDTGMTGAIPAGATSMTKIPAGTDCTYIFDIPKGFAIKMETSAVYDVSPGDSIKFDYFYISSPAEKEVEYAVNQTLPYEVISKTGNLTFFATYTYIDMTNYQQVIKPTGTYFNATLETDKYFTVQAADNDQVVLKYGSRQTGFVDTSIYEVFVFDGNDILNSKYLGRLTELYRRPQYDVSSTSNTLTLLDLYGMPSDSLLLGNDASTVENMGQYSVFVIDSDKELDGYMGNYELEPDSWYTFICNDCSSFTIGAMTFDRKFENASGYIEVQGMSPTQKLQPVLKYPYSTNSNSSFPQLIPSPMATFHIHNASVTFVVKPGVPQNDFAAAPGQSRSVYSPQIWNPAAEPKFDYTFSDPVKVYNFSINLQTVKLENDGDELDVQVGSVDGLTTLDKKYNKDTKSDAYLSGIGRYLNLKYTGSKTSEVILNFVMIDRLNPDGTTQSPGTTVVPSGSFSTAPIVTSVSTRATRVSSSTAPVVSTVTSTITSQSIVTTNKSSSPITSKTTTSINVSSSTTKSTRPMQSTTTYQKLAQASSTASTTPIPITTQNISTASIATPSTKTPITPSLITTRSSTTKLSPIVITKSSLAYTATPTSAAPSTSALTITTHTTPIPGVLTSKTTSKTVDLTTATQSVQTPISTDPILHHTTPSSFTIGTTQFFTEISTVNPKRLTGSTATSVHVETTTKGTSSLFSAGFLIIVISALTL
Protein: Rubredoxin-like superfamily protein (Q9FI47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Glutaredoxin-C3
- Probable inactive patatin-like protein 9
- Peptide methionine sulfoxide reductase A1
Sequence:
MAMQLPPTTLYAGRSSVVLPPTTPTLQRSSFLPYYSMRLLGNKKSLSKSSAPRFSMRVSSKQAYICRDCGYIYNDRTPFDKLPDNYFCPVCAAPKRRFRAYMPDVSKNVNDKDVRKARKAELQRDEAVGKALPIGIAVGVLALAALYFYVNSTS