wanglab/gogpt-training-data huggingface dataset:
Protein: F box and leucine-rich-repeat gene 4 (GH11272p) (Q9VY46)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Wide awake
- Cullin homolog 1
- Calmodulin-binding transcription activator, isoform F
Sequence:
MSLLAYGEPAESSETDSPAAEAEPDVLVDFTAMLQRQRQNGDYGGWFGCDSKMQTTQSDQGYYLEQYVLGVLDFSSQYGIDYSISYTAANVIGRPTKFPAYGDYPETFPMRTYGDWWQRAPSATREIQPQNLPKLETHDYVVVYFEEFVVPTEVAIFETFNPGAVVRIWAYGLTKNWTCLWEATESDLSRPPPLDSRRFAPSLKKTTMLTKTLRIDFNHSRLNYYTEIDAIMLCGRTVTKTQNLLAKQQITQHSRTLVSPPPDAIGSTSGDGSGGSISHKLRTLKFQPNCGEDGATKLHEFINNDLSQFLADNCVDGEAAAPQICLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPYWDVASSELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTYFETELLLSMLEGNRKLKHLNLAFCGVSVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSLARLHQLEELDLGWCMREASLGDGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYDILVNCPKLQLLDLSFCDNIMDRDFDLLAEWSRQFKVDIKSSRRH
Protein: GEO08953p1 (GH20534p) (Q9VIL5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Accessory gland-specific peptide 26Aa
- Serpin 28F
- Accessory gland protein Acp62F
- IP02289p
- Odorant-binding protein 56g
- ACP53C14A
- Accessory gland protein Acp36DE
- Uncharacterized protein, isoform A
- RT03039p
- Accessory gland protein Acp76A
Sequence:
MKIIALLVLANLGFALSSKEYDEHERLVTWRLRNIVNKYKYLATGNAEFSRWIEKVNNAAARSNLEVKLDTEGYFKVYDEQRQLLEDNITQRLNTLRSLISLRKGGKRCVRFYQHQENELKNAYKFSNQKKEEVFVNSLKKCFAPPAIQEYDYDYYLGY
Protein: Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) (P15927)
Organism: Homo sapiens (Human)
Function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
Subcellular location: Nucleus {ECO:0000269|PubMed:10982866, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906}. Nucleus, PML body {ECO:0000269|PubMed:12814551}. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. {ECO:0000269|PubMed:12814551}.
Interaction partners:
- Replication protein A 14 kDa subunit
- RecQ-mediated genome instability protein 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
- DNA repair protein RAD52 homolog
- Replication protein A 70 kDa DNA-binding subunit
- Claspin
- DNA topoisomerase 3-alpha
- RecQ-like DNA helicase BLM
- Fanconi anemia group M protein
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
Sequence:
MWNSGFESYGSSSYGGAGGYTQSPGGFGSPAPSQAEKKSRARAQHIVPCTISQLLSATLVDEVFRIGNVEISQVTIVGIIRHAEKAPTNIVYKIDDMTAAPMDVRQWVDTDDTSSENTVVPPETYVKVAGHLRSFQNKKSLVAFKIMPLEDMNEFTTHILEVINAHMVLSKANSQPSAGRAPISNPGMSEAGNFGGNSFMPANGLTVAQNQVLNLIKACPRPEGLNFQDLKNQLKHMSVSSIKQAVDFLSNEGHIYSTVDDDHFKSTDAE
Protein: Gamma-sarcoglycan (Gamma-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) (Q13326)
Organism: Homo sapiens (Human)
Function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Alpha-sarcoglycan
- Dystroglycan 1
- Sarcospan
- Dystrophin
- Delta-sarcoglycan
- Beta-sarcoglycan
- Filamin-C
- Beta-1-syntrophin
- Alpha-1-syntrophin
- Epsilon-sarcoglycan
Sequence:
MVREQYTTATEGICIERPENQYVYKIGIYGWRKRCLYLFVLLLLIILVVNLALTIWILKVMWFSPAGMGHLCVTKDGLRLEGESEFLFPLYAKEIHSRVDSSLLLQSTQNVTVNARNSEGEVTGRLKVGPKMVEVQNQQFQINSNDGKPLFTVDEKEVVVGTDKLRVTGPEGALFEHSVETPLVRADPFQDLRLESPTRSLSMDAPRGVHIQAHAGKIEALSQMDILFHSSDGMLVLDAETVCLPKLVQGTWGPSGSSQSLYEICVCPDGKLYLSVAGVSTTCQEHNHICL
Protein: E3 ubiquitin ligase complex SCF subunit sconC (Sulfur controller C) (Sulfur metabolite repression control protein C) (Q5BAX8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
Interaction partners:
- JmjC domain-containing histone demethylation protein 1
- Cullin-1
- Probable E3 ubiquitin ligase complex SCF subunit sconB
- Probable E3 ubiquitin ligase complex SCF subunit sconB
- RING-box protein 1
- SCF E3 ubiquitin ligase complex F-box protein grrA
- Probable E3 ubiquitin ligase complex SCF subunit sconB
- Leucine Rich Repeat domain protein
- F-box protein
- Protein phosphatase PP2A regulatory subunit B
Sequence:
MAEKMLVMTSNDGKNIEVPRDVAERSLLIKNMLEDLGDPTEPIPIPNVSENVLSKVLEWCAHHRNDPPSSADDDDSRRKTTDIEEWDQKFMQVDQEMLFEIILAANYLDIKPLLDIGCKTVANMIKGKSPEEIRKTFNIQNDFTPEEEDQIRRENEWAEDR
Protein: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) (Q61425)
Organism: Mus musculus (Mouse)
Function: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (By similarity). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion.
Subcellular location: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:35339755}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:35339755}. Cytoplasm, cytosol {ECO:0000269|PubMed:35339755}. Note=Predominantly nuclear. {ECO:0000269|PubMed:35339755}.
Interaction partners:
- Enoyl-CoA hydratase, mitochondrial
- Trifunctional enzyme subunit beta, mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- 3-ketoacyl-CoA thiolase A, peroxisomal
- 3-ketoacyl-CoA thiolase B, peroxisomal
- Acetyl-CoA acetyltransferase, mitochondrial
- Acetyl-CoA acetyltransferase, cytosolic
- Acetyl-Coenzyme A acetyltransferase 3
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- 3-hydroxyacyl-CoA dehydrogenase type-2
Sequence:
MAFVTRQFLRSMSSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAGDEFVEKTLSCLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK
Protein: Anion exchange protein (Q3KVL6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU362035}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362035}.
Interaction partners:
Sequence:
MSDPQDASDVTSAAGLTRHLPIALQPPPQRCDDEDEGDLNKTLGVQRFQQILTPPQRVPTEQHRTFNEEDFEYHRHTSLHIHHPLSKHLPDGRRKKPGRKRKDSGRRRSSSMGAAPPIDEDDEDEEADEDSCSQQDREGNVTTTPTPDTDTEDRERAQFFVSEDDPKKNGEVSSHRKPSITSHSKLHTSISIPEDVTGASGRRWGRIPPNGRRVSAPCLFPSVSSPDGSCKTGRSYDLQERRRTGNMTGATLSHYQQMPTDESEAKTLATVDLDGIKSHRFEDVPGVRRHLVKKSAKGQVVHIGKDYKEFSSRIRTKLDRTPHEVFVELNELLMDKNQEMHWKETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRKTISHGAVLLDLDQKTLPGIAHQVVEQMIISDQIRAHDRANVLRALLLKHSHPSDGKEHSLFNRNISATSLGSLISHYHSTNHIGAPELPATDPLIGGLRNFESRSSVDYVEKNEKDSPQFFGLHKTKSKHELKLLEKIPEDAEATVVLVGCVDFLDQPTMAFVRLKEAVLLESVLEVPIPVRFLFVLLGPPSANIDYHQIGRSISTLMSDKHFHEAAYLADGRQDLLTAINSFLDCSIVLPPSEVGGDELLHSIARFQKEMLHKRHEQEVKLQAKEPKSPDDIALQPPLKPEDDPLRRTGRLFGGVIRDVRRRYPKYISDFKDALSPQCMATVIFIYFAALSPAVTFGGLLGEKTDGLIGVSELIISTAVQGMLFCLLGAQPLLIVGFSGPLLVFEEAFYSFCKSNDLEYLTGRMWIGMWLIIIVLLTVAFEGSFLVRFVSRFTQEIFSILISLIFIYETFFKLGKIFMDHPLRSCSGPEENATSLSTGSNDSRSTGASQTLNQPNTALLSLVLTSGTFFIAYYLRKFKNSAFFPGRLRRAIGDFGVPIAISTMVLLDYSIKDTYTQKLNVPDGFSVTSPDKRGWLIHPLGSDGQFPIWMMGACILPALLVYILIFMETQITTLIVSKKERMLVKGSGFHLDLLIIVVSGGIAALFGLPWLTGATVRSVTHANSLTVMSKAVAPGDKPRIQEVKEQRVTGFLVALLVGLSIVIGDLLRQVPIAVLFGIFLYMGVMSLNGIQLTERMMLLFMPPKYHPDHTYVRKVRTLRMHLFTCLQLVCLAVLWIVMSTAASLAFPFVLVLTVPFRRFLLSRIFSHREIQCLDADDAEPTLDDKDGQDEYTEMQMPV
Protein: ORF 64 (O40942)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MAAQPLYMEGMASTHQANCIFGEHAGSQCLSNCVMYLASSYYNSETPLVDRASLDDVLEQGMRLDLLLRKSGMLGFRQYAQLHHIPGFLRTDDWATKIFQSPEFYGLIGQDAAIREPFIESLRSVLSRNYAGTVQYLIIICQSKAGAIVVKDKTYYMFDPHCIPNIPNSPAHVIKTNDVGVLLPYIATHDTEYTGCFLYFIPHDYISPEHYIANHYRTIVFEELHGPRMDISRGVESCSITEITSPSVSPAPSEAPLRRDSTQSQDETRPRRPRVVIPPYDPTDRPRPPHQDRPPEQAAGYGGNKGRGGNKGRGGKTGRGGNEGRGGHQPPDEHQPPHITAEHMDQSDGQGADGDMDSTPANGETSVTETPGPEPNPPARPDREPPPTPPATPGATALLSDLTATRGQKRKFSSLKESYPIDSPPSDDDDVSQPSQQTAPDTEDIWIDDPLTPLYPLTDTPSFDITADVTPDNTHPEKAADGDFTNKTTSTDADRYASASQESLGTLVSPYDFTNLDTLLAELGRLGTAQPIPVIVDRLTSRPFREASALQAMDRILTHVVLEYGLVSGYSTAAPSKCTHVLQFFILWGEKLGIPTEDAKTLLESALEIPAMCEIVQQGRLKEPTFSRHIISKLNPCLESLHATSRQDFKSLIQAFNAEGIRIASRERETSMAELIETITARLKPNFNIVCARQDAQTIQDGVGLLRAEVNKRNAQIAQEAAYFENIITALSTFQPPPQSQQTFEVLPDLKLRTLVEHLTLVEAQVTTQTVESLQAYLQSAATAEHHLTNVPNVHSILSNISNTLKVIDYVIPKFIINTDTLAPYKQQFSYLGGELASMFSLDWPHAPAEAVEPLPVLTSLRGKIAEALTRQENKNAVDQILTDAEGLLKNITDPNGAHFHAQAVSIPVLENYVHNAGVLLKGEKSERFSRLKTAIQNLVSSESFITVTLHSTNLGNLVTNVPKLGEAFTGGPHLLTSPSVRQSLSTLCTTLLRDALDALEKKDPALLGEGTTLALETLLGYGSVQDYKETVQIISSLVGIQKLVRDQGADKWATAVTRLTDLKSTLATTAIETATKRKLYRLIQRDLKEAQKHETNRAMEEWKQKVLALDNASPERVATLLQQAPTAKAREFAEKHFKILLPVPADAPVQASPTPMEYSASPLPDPKDIDRATSIHGEQAWKKIQQAFKDFNFAVLRPADWDALAAEYQRRGSPLPAAVGPALSGFLETILGTLNDIYMDKLRSFLPDAQPFQAPPFDWLTPYQDQVSFFLRTIGLPLVRALADKISVQALRLSHALQSGDLQQATVGTPLELPATEYARIASNMKSVFNDHGLQVRSEVADYVEAQRADAHTPHVPRPKIQAPKTLIPHPDAIVADGLPAFLKTSLLQQEAKLLALQRADFESLESDMRAAEAQRKASREETQRKMAHAITQLLQQAPSAISGRPLSLQDPVGFLEGIIYDKVLERESYETGLEGLSWLEQTIKSITVYAPVEEKQRMHVLLDEVKKQRANTETALELEAAATHGDDARLLQRAVDELSPLRVKGGKAAVESWRQKIQTLKSLVQEAEQAGLLLATIDTVAGQAQETISPSTLQGLYQQGQEAMAAIKRFRDSPQLAGLQEKLAELQQYVKYKKQYLEHFEATQSVVFTAFPLTQEVTIPALHYAGPFDNLERLSRYLHIGQTQPAPGQWLLTLPTFDPTRPACVPAGGHEPPLHRQVVFSSFLEAQIRLALSVAGPVPGRGLPGTPQIRRGVEAAACFLHQWDEISRLLPEVLDTFFHNAPLPAESSSNAFLAMCVLTHLVYLAGRAVLGPREPEHAAPDAYPREVALAPRDLTYLLLAMWPSWISAILKQPSHAEAAHACLVTLPTMLKAVPYLTLEASAGPLPADMRHFATPEARLFFPARWHHVNVQEKLWLRNDFMSLCHRSPGRARIAVLVWAVTCLDPEVIRQLWSTLRPLTADESDTASGLLRVLVEMEFGPPPKTPRREAVAPGATLPPYPYGLATGERLVGQAQERSGGAGKMPVSGFEIVLGALLFRTPLRIFSTASTHRISDFEGGFQILTPLLDCCPDREPFASLAAAPRRTVPLGDPCANIHTPEEIQIFARQAAWLQYTFANYQIPSTDNPIPIVVLNANNNLENSYIPRDRKADPLRPFYVVPLKPQGRWPEIMTTATTPCRLPTSPEEAGSQFARLLQSQVSATWSDIFSRVPERLAPNAPQKSSQTMSEIHEVAATPPLTITPNKPTGTPHVSPEADPITERKRGQQPKIVADNMPSRILPSLPTPKPREPRITLPHALPVISPPAHRPSPIPHLPAPQVTEPKGVLQSKRGTLVLRPAAVIDPRKPVSAPITRYERTALQPPRTEGEGRRPPDTQPVTLTFRLPPTAPTPATAALETKTTPPSTPPHAIDISPPQTPPMSTSPHARDTSPPAEKRAAPVIRVMAPTQPSGEARVKRVEIEQGLSTRNEAPPLERSNHAVPAVTPRRTVAREIRIPPEIKAGWDTAPDIPLPHSSPESSPPTSPQPIRVDDKSPLPNLVERYARGFLDTPSVEVMSLENQDIAVDPGLLTRRIPSVVPMPHPIMWSPIVPISLQNTDIDTAKITLISFIRRIKQKVAALSASLAETVDRIKKWYL
Protein: LD20590p (Versatile) (Q9VTT2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD33778p
- Adaptor protein complex 1, mu subunit
- Ankyrin 2, isoform U
- Protein telomere ends associated
- Uncharacterized protein, isoform A
- MADF domain-containing protein
Sequence:
MPSRNIDDAAGAKEVHRSTRNSLIGPKSKRIALNSRNRSLAAAEKKTQSQLSFPPKSEYEKFYETVFLAEDLQPEENITPERRKPGPRMKSSLQALLSDEGSPTGPQRTAKINVAQKMVVEPAIRANGISPLPKNVGKEEKFEDYYTKTERHVWKKDAEKMLLQLWAQHLKDFRGESKNVIIYRQMAREMSQFGPSHTELKTKMDNLSRKYRIEAERVRETGVPSKWEHFHKLQALLIGTKSVDVFEDITAENPAQALFSDEDYEPEELSSLKDEPMAGDDGNVFESDMVASKAMKRTRTPSPSIPEIPEEDEEEEEEEEDDDHMKDLSPSPISKCQTKRKASNNHSDRLLEIEEEKLAIEREKLQVMKDALLELNAFHKDIVYLLKHNNQ
Protein: Uncharacterized protein (Q2F920)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MKGKECKPRTSERRKRNVLQRNTIKRKWGRTKDGAHSSPIAAKVPYVSRRTRVEVNSSAELSAACFQVSSQAQNHPDDSRYSSGRGLASISTRREYGLSPRQQRGGGDLHGATRGVRNSGKRRSHMVVEEELVWAPRQWSKKFDKFMVDRYLSIPVVGADEPPSVLAAALGGL
Protein: Protein BOP3 (Bypass of PAM1 protein 3) (P53958)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in resistance to methylmercury. Overexpression suppresses a PAM1-SLV3 double null mutation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YER034W
- Cyclin-dependent kinase 1
Sequence:
MSTFNSYSQPKESNDNSHNNVNKSKSLLDIIFGTNVSEWAFSENALMKAMDLKIEQEKTKQQYYKLENLNRSIELFKLASSSGLPINQIHKLFNTDHGVPASSPMKAGGNQPHNNTEGTQSSENLPRLNGSMKSLKPLNMNTVSPTPMSRQPSPYKFPASSSTGGISHSTVTNVQRRANSPARIGASAVAALNDNISIKEEDVARRIPSGTKSQESPLNKKPTSLHSRNLSLPIGKFTNPNIPSTMTSILSFNRDQQQPLSQPLPPPPQQQQDLHTHNLHTIPRKPGMVQKKHRRARSTSSFGVIDLSIIDEAKEKQVQRSPSPIHSNVSVALTSHDKPIESNMKEQPNMLQSVREGRQVHDDLDDRTCSESSSRNESPVRTITKDNSVGKILNST
Protein: Zinc finger CCCH domain-containing protein 17 (AtC3H17) (Q9ZUM0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein MODIFIER OF SNC1 11
- Zinc finger CCCH domain-containing protein 59
- Paramyosin
- THO complex subunit 2
- Zinc finger CCCH domain-containing protein 36
- Zinc finger CCCH domain-containing protein 3
- Zinc finger CCCH domain-containing protein 37
- Zinc finger CCCH domain-containing protein 21
- Zinc finger CCCH domain-containing protein 54
- Zinc finger CCCH domain-containing protein 14
Sequence:
MFAPATQPQQQHEQKKQSETVSSAEEDALKWNTDCVYFLASPLTCKKGPECEYRHSEYARMNPRDCYYWLNGNCLNPKCGFRHPPLEGLLGNQGGAPAVSVQPIHATAQHPSVAKQPVPCLFFQKGMCMKGDMCSFLHTPNPAAYKKQHPVEAKPATDPQCSKKPIENNTEEKKLPDVNLSKVVKGHTDISAAPRVASTGLRDSRSVEGYIPNHVGYEPVVQRKGPGFPSFTEGGHSTQLLQKYGSDDNNSFHNGKDADDVLRESSPGFDVLVDNEAGDSEYYHVEDRYGRRSQERGNSEYDPDFSAIADGDKEALREQRFDSYDRREDRGWGHRRVSSEREDRLDRRVYAEDERSENILESDLRYRLAKQRKGNGMRLSVGGHDYAAPDSSMDRGYRESRRDTPRENSISSSRLQGRIKLRERSNGEEGHHFDRRSERGRDRSELPSQGRLRDRIKGRLEENHSGNQERGFGAPWARRREMEDERKSAPKSSREESKPEPSLGKRKSFEEDHHSHKRSRDSFAAPLPFSEILKRKKAAASGGSRNNNKDETISKEEAGDEIKLITEEKTEVVSEPKAEVEEEGTVMEEEEIVGEEVYEGNEDEQAYEGDELNGEYYYEEGYEEEGGEYAYEEGEEVVYAAEEGEEEATEGGEGEGEEDIEKKTVEMLS
Protein: Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (Growth cone membrane protein 23-48K) (GMP23-48K) (p50 dynamitin) (Q99KJ8)
Organism: Mus musculus (Mouse)
Function: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14983524, ECO:0000269|PubMed:9144527}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Actin-related protein 10
- Dynactin subunit 6
- Dynactin subunit 4
- Dynactin subunit 1
- Dynactin subunit 3
- Alpha-centractin
- Dynactin subunit 5
- Beta-centractin
- Cytoplasmic dynein 1 intermediate chain 1
- Protein bicaudal D homolog 2
Sequence:
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELSSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSSKGSSGGKATAGAPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYETIQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRENLATVEGNFASIDARMKRLGK
Protein: Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) (P55051)
Organism: Rattus norvegicus (Rat)
Function: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.
Subcellular location: Cytoplasm.
Interaction partners:
- Gastrotropin
- Fatty acid-binding protein, liver
- Fatty acid-binding protein 5
- Fatty acid-binding protein, heart
- Fatty acid-binding protein, adipocyte
- Glial fibrillary acidic protein
- Excitatory amino acid transporter 1
- Nestin
- Paired box protein Pax-6
Sequence:
MVDAFCATWKLTDSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGGKVVIRTQCTFKNTEISFQLGEEFEETSIDDRNCKSVIRLDGDKLIHVQKWDGKETNCVREIKDGKMVVTLTFGDVVAVRCYEKA
Protein: Thy-1 membrane glycoprotein (Thy-1 antigen) (CD antigen CD90) (P01831)
Organism: Mus musculus (Mouse)
Function: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Integrin alpha-M
- Integrin beta-2
- 5'-nucleotidase
- Endoglin
- Receptor-type tyrosine-protein phosphatase C
- Hematopoietic progenitor cell antigen CD34
- Integrin beta-2-like protein
- Rho GTPase-activating protein 35
- Rho GTPase-activating protein 5
- Ephrin type-A receptor 4
Sequence:
MNPAISVALLLSVLQVSRGQKVTSLTACLVNQNLRLDCRHENNTKDNSIQHEFSLTREKRKHVLSGTLGIPEHTYRSRVTLSNQPYIKVLTLANFTTKDEGDYFCELQVSGANPMSSNKSISVYRDKLVKCGGISLLVQNTSWMLLLLLSLSLLQALDFISL
Protein: Regulator of MON1-CCZ1 complex (Protein Bulli) (Q9VRX1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Late endosome {ECO:0000269|PubMed:32499409}. Note=Colocalizes with Rab7, but not Rab5 positive endosomal structures. {ECO:0000269|PubMed:32499409}.
Interaction partners:
- Vacuolar fusion protein CCZ1 homolog
- Vacuolar fusion protein MON1 homolog
Sequence:
MDNSNGIHYIELTPNPIRFDAVSQLTNVFFDDSNKQIFAVRSGGATGVVVKGPGSPDDVVISFCMSDRGGAIRSIKFSPDNQILAVQRKENSVEFICFQGDQPLLQDIITHQVKTLIHGFVWVHNREVALISNTGVEVYTVVPEKRQVRSVKSLSIGIKWFAWCCDANVALLCTSEGNSLIPVLVKQKVITKLPKVDLGNPSRDVQESKVTLGQVYGVLAVLILQSNSTTGLMEVEVHLLNGPGLAPRKCHVLRLSLLGRFAINTVDNLIVVHHQASGTSLLFDISLPGEVINEITYHTPITPGRSIKPFGLKLPSLSPDGQILQCELYSTHWVLFQPNIVIDAKLGCMWFLNLCIEPLCQLISDRIRLTEFLLQRSNGKQMLLKVIGQLVDDQYKGTLLPVLETIFSRINKIYASWVQLELQNQTAQPSNVKTTTLKQSTPPIVLIEQLDMVQIFQRIARRPYTESILMLYLQSLNKFNIAAQEELSKMIISELISNRSFDTLRRLVSYSMLLESKSVACFLLSHSNVDTAISQVAIDMLGRIEAHEIIIEVMLGQGKVIDALRLAKNSMGLEKVPARKFLEAAHKTKDDLIFHSVYRFFQMRNLKLYETLSFPKAEQCTEFIQHYNNTFPADNPTRQPVS
Protein: Skywalker, isoform D (Skywalker, isoform E) (Skywalker, isoform G) (Q0E8N9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MPYHRGGDASSQADKLSGIVEESDLYEGFAPHVETSEIKTLDFYNLPKQTGKEPALRSYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLDGFYWEMVHQVFGTTELSEKPIMLPAFVDATHCLPYHLTSTGRAVADRIVNVLGYDCPDITYSPVLYPITSILLHFMSEEEAYICLAGLVGSKEKVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQRICPGLKLERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDNIKNDIGNALIKFCKKIPVSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLKSRSVLTSGSKQLIKSRSSDNLPTSQSQVNIQMMSHTLTIRELFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCNNEVFGAYCSSRWFERNVKDDKGQRQAYFGTGETFLFSLYPERAKYPWVGIEGDKDLGHSSELFMAADSKMITIGGGEGQAIWMDENIRFGKTDSCKTFNNPPLCPSGDFEIRVLEVYGFVGI
Protein: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6) (Q9UBK2)
Organism: Homo sapiens (Human)
Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity).
Subcellular location: [Isoform 1]: Nucleus {ECO:0000269|PubMed:10713165}. Nucleus, PML body {ECO:0000250|UniProtKB:O70343}.; SUBCELLULAR LOCATION: [Isoform B4]: Nucleus {ECO:0000269|PubMed:22589246}.; SUBCELLULAR LOCATION: [Isoform B4-8a]: Cytoplasm {ECO:0000269|PubMed:22589246}. Nucleus {ECO:0000269|PubMed:22589246}.; SUBCELLULAR LOCATION: [Isoform B5]: Nucleus {ECO:0000269|PubMed:22589246}. Nucleus, PML body {ECO:0000269|PubMed:22589246}.; SUBCELLULAR LOCATION: [Isoform 9]: Nucleus {ECO:0000269|PubMed:22009745}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma
- Nuclear respiratory factor 1
- Steroid hormone receptor ERR1
- Forkhead box protein O1
- Peroxisome proliferator-activated receptor alpha
- NAD-dependent protein deacetylase sirtuin-1
- Hepatocyte nuclear factor 4-alpha
- Cyclic AMP-responsive element-binding protein 1
- Transcriptional repressor protein YY1
- Histone-lysine N-methyltransferase PRDM16
Sequence:
MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR