wanglab/gogpt-training-data huggingface dataset:
Protein: Dendrin (P50617)
Organism: Rattus norvegicus (Rat)
Function: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein.
Subcellular location: Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Nucleus {ECO:0000250}. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. {ECO:0000250}.
Interaction partners:
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
- Synaptopodin
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
- Nucleoplasmin-3
Sequence:
MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAASRQSMDIQASYWARGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPLGQPRPELRNALRAAQPTGFPVFSRPERFGQVGRAPRPSALPQGDPGVAWAGPWGGRRPGPPSYEAHLLLRGAAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCAAARARPESCKGAVEKSSGLAAAGLNSGGDGHSQAKTTGPVTEVALSGSTISSPPRPVPRSRQHLRGSRKGKEGSEEMWLPTCWLSSPKKPPVRHSQTLPRPWAPGGTGWKESLGQREGTEHETLEVWKVTRRAHTLPRSSRGPAGREGIFVIDATCVVIKSQYVPTPRTQQRQLAPSGESCIVSDSLRQPKPCLEEEGKGAAANPSVCQKRLLSSRVLNPPSEGREFEAEGRQQGDSSLEERSSSGLGFPVGEVNPRDAPTHPGSPEHSTLGPAAPGCAGSVKGPEAAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEAEDLSAHSGSSDGSDTDAPGASWRNERTLPAVGNTRPREGGKTAELGDSIGEILDVISQTEEGLVREDTRKTPQGKRE
Protein: Nuclear control of ATPase protein 2 (Q12374)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the mitochondrial expression of subunits 6 and 8 of the F0-F1 ATP synthase.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}.
Interaction partners:
- Beta-glucosidase-like protein NCA3
- Mitochondrial translation factor ATP22
- Vacuolar fusion protein MON1
- ATPase synthesis protein 25, mitochondrial
- ATPase expression protein 3
- Vacuolar fusion protein CCZ1
- ATPase expression protein 1, mitochondrial
- ATP synthase protein 8
- Mitochondrial hydrolase YKR070W
- MIOREX complex component 5
Sequence:
MIINRRILKSFEEISHSLEESLREVAFDSQQQLIQDVREENEELSRLQDQLQLIRSIVEKICISIKTDNIDSYCSVPFDLLYNICKDIADPSSFEDGDLQYLVSQAIFEYIILLCYYSVTNECVQGLPAVYEAEQYYKTVSDSILKSFLYCLQNSVSTIRLLSQTVLKDVNKKKLSHQKWSLKALSVDLLEKIRPRINKFMVIRNFRFVGLPKKPIEIASLVSDIPRGIVHERLDMVTQSSKYYTIKLGQLITEFDQQPEENGMFTEVHLPNYERRLKSLQDFFGLAMSDSNLLDVIRCSAKFHKDHPLRRFTKPSILTRYWPSILLCLLYGPSSVMSLWNSRYFIQDFIKTNVVDFAKGLILNWLWAPLKQVWSTVKHDEGSAISVTSQETLNSDMDSLTRMIVSFVVDNSDSTSNSPIDPILLSTKVEHGDLTEFMEIYETQLHHPIKNIATGGLVRSLLIQLQKTKVDGSMALNGIDKMLKSQQLVFGVVALSPALVILYSSIVALKRFVKLGNVWSNEKRYREQISISLNNVERVLNYSKQGADADEEHLNQGLLVIEVSNLYKLGSFLIPRSRKKEWFRDVEELVDTNLDSGAHINVVNRIYHVYGRFLIH
Protein: TATA box-binding protein-like 1 (TBP-like 1) (21 kDa TBP-like protein) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein) (P62340)
Organism: Mus musculus (Mouse)
Function: Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes (By similarity). Seems to also mediate the transcription of NF1. Does not bind the TATA box.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Transcription initiation factor IIA subunit 1
- TFIIA-alpha and beta-like factor
- Transcription initiation factor IIB
- Transcription initiation factor IIA subunit 2
- TATA-box-binding protein
- TATA box-binding protein-like 2
- Nuclear transcription factor Y subunit alpha
- X-box-binding protein 1
- Transcription factor Sp1
- Recombining binding protein suppressor of hairless
Sequence:
MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL
Protein: C2H2-type domain-containing protein (Q8BIT2)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFNPQLQQQQQLQQQQQQLQQQLQQQQLQQQQQQILQLQQLLQQSPPQASLSIPVSRGLPQQSSPQQLLSLQGLHSTSLLNGPMLQRALLLQQLQGLDQFAMPPATYDGASLTMPTATLGNLRAFNVTAPSLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPPPVGVPINPSQLNHSGRNTQKQARTPSSTTPNRKTVPLEDREDPTEGSEEATELQMDTCEDQDSLVGPDSMLSEPQVPEPEPFETLEPPAKRCRSSEESTEKGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATEPQLSSHAAEAGSDPDKALPEPVSAQSSEDRSREASAGGLDLGECEKRAGEMLGMWGAGSSLKVTILQSSNSRAFNTTPLTSGPSPGDSTSATPAIASTPSKQSLQFFCYICKASSSSQQEFQDHMSEAQHQQRLGEIQHSSQTCLLSLLPMPRDILEKEAEDPPPKRWCNTCQVYYVGDLIQHRRTQEHKVAKQSLRPFCTICNRYFKTPRKFVEHVKSQGHKDKAQELKTLEKETGSPDEDHFITVEAVGCFESGQEEDEDDDEEEEEEGEIEAEEEFCKQVKPRETSSEQGKGSETYNPNTAYGEDFLVPVMGYVCQICHKFYDSNSELRLSHCKCPGPL
Protein: Alpha-1,3-arabinosyltransferase XAT3 (EC 2.4.2.-) (Xylan arabinosyltransferase 3) (OsXAT3) (Q10I20)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Glycosyltransferase involved in the arabinosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms. Possesses alpha-1,3-arabinosyltransferase activity, transferring an arabinofuranose residue to the xylan backbone.
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:22215597}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKAGERPKLVRGVRQESRRFRLLVIVVGFFLVSLTFVFVSKPDAILFSLNGKLPVEQAPTSILIQQKVNEPSGESRKTSTDALRGDPKVVDDEADAKPKGTGGGSEEEEGRVLSEPDPTSGMMEPTHNKDGNGHKSHQETLGGGGDGESKGNDEEGEHAEQKHKVTLPTVSNYTIHDAAEDTENAKQEGMNNVQQGSKPLCDFSNFRANVCEMRGDVRIHPTATSVLFMEPEGSQRDEVWKIKPYPRKGDEFCLSHITEVTVKSSKVAPECTKYHDVPAVIFSLTGYTGNLFHDFTDVLVPLFTTASEFNGEVQFLITDMALWWTIKYQTVLQKLSKYPVIDFSKDDQVHCFKHAIVGLHAYMEFTIDSTKAPHNYSMADFNRFMRGAYSLGRDSVTVLGEYPKIKPRLLIIKRHRTRMFLNLDEIISMAEELGFEVVIDEANVSSDISRFARLVNSVDVMMGVHGAGLTNCVFLPQHATLIQIVPWGGLDWISRTDFGNPAELMGLRYKQYSIGVDESSLTDQYPRDHEIFKNPISFHQRGFDFIRQTFMDKQNVKLDCKRFRPILLEALDNLNP
Protein: Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome aa3 subunit 2) (Cytochrome c oxidase polypeptide II) (Oxidase aa(3) subunit 2) (Q03736)
Organism: Cereibacter sphaeroides (Rhodobacter sphaeroides)
Function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MRHSTTLTGCATGAAGLLAATAAAAQQQSLEIIGRPQPGGTGFQPSASPVATQIHWLDGFILVIIAAITIFVTLLILYAVWRFHEKRNKVPARFTHNSPLEIAWTIVPIVILVAIGAFSLPVLFNQQEIPEADVTVKVTGYQWYWGYEYPDEEISFESYMIGSPATGGDNRMSPEVEQQLIEAGYSRDEFLLATDTAMVVPVNKTVVVQVTGADVIHSWTVPAFGVKQDAVPGRLAQLWFRAEREGIFFGQCSELCGISHAYMPITVKVVSEEAYAAWLEQARGGTYELSSVLPATPAGVSVE
Protein: Protein suppressor of underreplication (Q9VTE2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for underreplication of DNA, which is found in many late replicating euchromatic regions of salivary gland polytene chromosomes. Functions by promoting the localization and retention of Rif1 to active DNA replication forks where Rif1 inhibits replication fork progression. Controls chromatin organization in polytene chromosomes.
Subcellular location: Nucleus {ECO:0000269|PubMed:30277458}. Chromosome {ECO:0000269|PubMed:30277458}. Note=Localizes to the DNA replication forks and heterochromatin in amplifying ovarian follicle cells (PubMed:30277458). Binds to polytene chromosomes from salivary glands. Localized at late-replicating intercalary heterochromatin and pericentric heterochromatin. Colocalizes with many Polycomb Group proteins binding sites on polytene chromosomes. {ECO:0000269|PubMed:30277458}.
Interaction partners:
- Histone H1
- Histone H1
- Histone H1
- Histone H1
- Histone H1
- Telomere-associated protein RIF1
- Histone-lysine N-methyltransferase Su
- CDC45L
- Heterochromatin protein 1
- Protein suppressor of variegation 3-7
Sequence:
MYHFVSEQTPEVRLTDEALVTSHVTQYLKSFQLDAVRFVYDRLAKREFCILNDESGLGKVATVAALLSALPPAKKTLVVLQNDEQLLTGWRFHLDTLTDLQVYIIQGVQDTTDSPHSVYLAKWSQLRSIGDLSRLKFDYIMVDNRGHSLNNSFCTSMLLKQFEGRVNVLISSVDVTSDVRLLYNVLRLGGRLEHQYKSFASFDRKFHLPDPKEVFSKRIDLEEYYKQRGFLSEYIKDFRLRRFRHQFDKSLPLVAPEQYKHNLNLWLASKNSQSTISGSDVCSTIASIDNNPAQQNKTGLFEETDRLSEHSVDDVAMSPLIFEYSESDDEPLTVEPDADQNPVLVVSSDDCEIVTPPSTPQNRTPSLNESPRTKSKKKFSKKTSPRKKADLTDSEEDDEATDNMPPRKRTRAATVHLTPKTRRLNVRILRVSLDTLSTPPPSRTTTAIVTPKTEPTARRKNLKKRTVSPVDVGRPATRGMQRLTRSAETKINSKYLKHRSLDDVKRSFPRRVKLEGNQTPRSSKQIVKQEPKSKVGQEKKQKTVDVPAQGTAKRKPGRPRKCQTKTEDLGKTKTKPNSKHLPPTPQVLSGSSLSSEYMQCAQRIPDNLDAIESPAFRVPFTPQQTPMLLTLPSTHNLLNDSEVVSIPLYKDPVETVVINSSHDECSPQDPSQSRRTKALKRKRKPVTSVNSSFGGGLGLPPAKRSANKSPDLFSISSEHSQIPLAQPRPSSPFEGFKIFGSEVKQFQQQLAKVNISVPKKKRDRSCLDILEQMFEPRQQQSAKTSPKVLPTLPLTQKDDAESTITQRRRTLLEDDFFEITNNGQFGSRMRLNSSGEVSPVQPDQQSVRPSQANKITNYLIGSGITQERTQPSNGNRNSILASLRKSPKSPKQGAKSTQATKLTRWFGSVFGGGASQTSSVESVSAPSTPVNSSTSAAACQTRSARSGGASGPTKRKRLELFK
Protein: Basic-helix-loop-helix protein (Class E basic helix-loop-helix protein 40) (Q0D311)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MERITSAQPPPCMSKHPSLDISDMQGMDFPMYVYKPRRGMKRSEDSKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALNNLLEQQQQKIISLQNGLQIGEQGNGPSENSEEMFRSGFHLCAKEVLQFLANQETMRDLTTAHIIEHLQKVASELIQSPPSPRLDEPASKAQESREKPSGLQPKAAEGHAKNCVPVIQRTYPHSSEQSGSDTDTDSGYGGEYEKRDQKAQRPDCYVKESGALKYSSSIKEEQDEPPSKRPRSDSSEDESLSGHDVVGGHSPYVSFSPPQPLCMPFYLFPPGAAAAYLPMLEKCWYPGAMPVLYPGLGSSPASLSPEKLPSSMVMSSRVGSPVSTPTSMDSPALLQALKQVPPLNLETKD
Protein: Probable manganese-transporting ATPase catp-8 (EC 7.2.2.-) (Cation transporting ATPase 8) (P90747)
Organism: Caenorhabditis elegans
Function: Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9HD20}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HD20}.
Interaction partners:
Sequence:
MGVDQLVETIIPYNLRSIATHLYVPPFTIITAIWTYVWLNIFGYEEYYELGMLGYAAIFVILALVLLFCHWMMPVRCFLMCSKQEDVRIASHVCVIPTQNNGWPELVKLMRTTRDKQTKLWFEFQRVHYTWDEESREFQTKTLDTAKPMVFFQKSHGFEVEEHVKDAKYLLGDNKTEMIVPQFLEMFIERATAPFFVFQVFCVGLWCLEDMWYYSLFTLFMLMTFEATLVKQQMKNMSEIRNMGNKTYMINVLRGKKWQKIKIEELVAGDIVSIGRGAEEECVPCDLLLLRGPCIVDESMLTGESVPQMKEPIEDVEKDKIFDIETDSRLHVIFGGTKIVQHTAPGKAAEGMVKSPDGNCICYVIRTGFNTSQGKLLRTIMFGVKKATANNLETFCFILFLLIFAIAAAAYLWIKGSVDETRSKYKLFLECTLILTSVIPPELPIELSLAVNSSLMALQKLGIFCTEPFRIPFAGKVDICCFDKTGTLTTDNLVVEGVALNNQKEGMIRNAEDLPHESLQVLASCHSLVRFEEDLVGDPLEKACLSWCGWNLTKGDAVMPPKTAAKGISGIKIFHRYHFSSAMKRMTVVAGYQSPGTSDTTFIVAVKGAPEVLRNMYADLPSDYDETYTRLTRQGSRVLAMGIRKLGETRVGELRDKKRENFENDLAFAGFVVISCPLKSDTKTMIREIMDSSHVVAMITGDNPLTACHVSKVLKFTKKSLPTLVLDEPADGVDWMWKSVDGTIELPLKPETKNKMERKAFFNSHEFCLTGSAFHHLVHNEHTFLRELILHVKVFARMAPKQKERIINELKSLGKVTLMCGDGTNDVGALKHANVGVALLTNPYDAEKAAEKEKEKKAKIEEARSLVRSGAQLPQRPGAPGAPPAANAARRDAPPGARARAPLPPMANAAQARLDNLMKELEEEEKAQVIKLGDASIAAPFTSKYTSIASICHVIKQGRCTLVTTLQMFKILALNALVSAYSLSALYLDGVKFSDTQATIQGLLLAACFLFISKSKPLKTLSRQRPMANIFNAYTLLTVTLQFIVHFSCLLYIVGLAHEANTEKAPVDLEAKFTPNILNTTVYIISMALQVCTFAVNYRGRPFMESLFENKAMLYSIMFSGGAVFTLASGQATDLMIQFELVVLPEALRNALLMCVTADLVICYIIDRGLNFLLGDMF
Protein: Reverse rubrerythrin-2 (revRbr 2) (NADH peroxidase) (NPXase) (Npx) (EC 1.11.1.1) (Rubperoxin 2) (Rpr 2) (Q97D83)
Organism: Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W)
Function: Functions as the terminal component of an NADH peroxidase (NADH:H(2)O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) as the electron transport intermediary from NADH to revRbr 2. Plays an important role in the oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. Also exhibits NADH oxidase (NADH:O(2) oxidoreductase) activity in vitro, which is 100-fold lesser than that of FprA1/2 using the same electron transfer components. Therefore, its predominant function is most likely as a scavenger of its preferred substrate, H(2)O(2).
Interaction partners:
- Reverse rubrerythrin-1
- Rubredoxin
- Transcriptional regulator PerR
- Desulfoferrodoxin
- NADH-rubredoxin oxidoreductase
- Flavo-diiron protein FprA2
- Flavo-diiron protein FprA1
Sequence:
MKKFKCVVCGYIYTGEDAPEKCPVCGAGKDKFVEVKDEGEGWADEHKIGIAKGVDKEVLEGLRANFTGECTEVGMYLAMARQADREGYPEVAEAYKRIAFEEAEHASKFAELLGEVVVADTKTNLQMRVDAEKGACEGKKELATLAKKLNYDAIHDTVHEMCKDEARHGSAFRGLLNRYFK
Protein: Ceramide transporter 1 (A0A2R8Y7C5)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
Sequence:
MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKKKSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFSSVGTHRFVQKVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVTEARLCDIPCWRKKEKKKLNALSWNVGSIALSVAQDLGLVYKNDKILQ
Protein: Vacuolar iron transporter 1 (Q57WW3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- Metal-ion transporter, putative
Sequence:
MSESEKIDVSGARNYKSISAARKAFETGDIEMSRMEHQKHIYKEVHNPSASDYVKSVVFGGLDGIITSFTVVSAAVGSNSSVASVLIFGFSNVIADGFAMGFGEYVSGEAERDNALSERRREEWEVENAFDMEVDEMVQIYEMKGLSHEDATTIVNIISKDPKLFVDFMMTEELGIIIDTEDTHGPKKQGLVMFLSFMFFGAVPLLAYLPGKGKGIDGVFALSCFLATCALIVLGMLRGYLSGVSMLRSAALMVFNGVVSGLFSFTVGSLVEHALRSSIEV
Protein: KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1) (SLM-1) (rSLM-1) (Q920F3)
Organism: Rattus norvegicus (Rat)
Function: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis (By similarity). Binds both poly(A) and poly(U) homopolymers (By similarity). Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9WU01}.
Interaction partners:
- Tyrosine-protein kinase
Sequence:
MGEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGRKEDEEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEESGRGRGIRGRGIRITPTAPSRGRGGAVPPPPPPGRGVLTPRGTTVTRGALPVPPVARGVPTPRARGTAAVPGYRAPPPPAPEAYEEYGYDDGYGGEYDDQTYEAYDNSYVTPTQSVPEYYDYGHGVNEDAYDSYAPEEWTTTRSSLKAPPPRSARGGYREHPYGRY
Protein: Apelin receptor early endogenous ligand (Protein Elabela) (ELA) (Protein Toddler) (P0DMC3)
Organism: Homo sapiens (Human)
Function: Endogenous ligand for the apelin receptor (APLNR). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis. Drives internalization of APLNR. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating APLNR. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Plays a role in placental vascular development; promotes placental trophoblast invasion and spiral artery remodeling in the uterus. Involved in the regulation of maternal cardiovascular homeostasis to prevent gestational hypertension and for potent cardioprotective functions during heart failure. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:24316148, ECO:0000269|PubMed:28137936}. Secreted, extracellular space {ECO:0000269|PubMed:28137936}. Note=Found in blood plasma (PubMed:28137936). Found in serum of pregnant mice, peaking at midgestation; indicating a maternal and zygotic origin of circulating APELA during pregnancy (By similarity). {ECO:0000250|UniProtKB:P0DMC4}.
Interaction partners:
- Apelin receptor
- Apelin
Sequence:
MRFQQFLFAFFIFIMSLLLISGQRPVNLTMRRKLRKHNCLQRRCMPLHSRVPFP
Protein: Small integral membrane protein 1 (Vel blood group antigen) (B2RUZ4)
Organism: Homo sapiens (Human)
Function: Regulator of red blood cell formation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26452714}; Single-pass type II membrane protein {ECO:0000269|PubMed:26452714}.
Interaction partners:
Sequence:
MQPQESHVHYSRWEDGSRDGVSLGAVSSTEEASRCRRISQRLCTGKLGIAMKVLGGVALFWIIFILGYLTGYYVHKCK
Protein: Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 (EC 2.7.11.1) (Q9LFG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MIPPNINVLIRSICINLVTSLPLNFAYIFIHFAVNALREIKRSLIDPMRNLSNWAKGDPCNSNWTGIICFGRSHNDGHFHVRELQLMRLNLSGELAPEVGQLLYLEILDVMWNNLTGRIPLEIGRISSLKLLLLNGNKFTGSLPPELGNLQNLNRLQVDENNITGSVPFSFGNLRSIKHLHLNNNTISGEIPVELSKLPKLVHMILDNNNLTGTLPLELAQLPSLTILQLDNNNFEGSTIPEAYGHFSRLVKLSLRNCGLQGSIPDLSRIENLSYLDLSWNHLTGTIPESKLSDNMTTIELSYNHLTGSIPQSFSDLNSLQLLSLENNSLSGSVPTEIWQDKSFENNKLQVYDLNNNFSDATGNLRTPDNVTLYLRGNPICKSTSIPMVTQFFEYICGEKKQTSTNSNTPCSNVSCPFENVKVSPGICLCTAPLSIDYRLKSPSFFFFTPYIERQFREYITSSLQLETHQLAIDRLVDENRLRPRMYLKLVPKGRITFNKSEVIRIRDRFMSWSFNKTDFFGPYELLDFPLQGPYADLLAQTSGIRTIVWMMIVAGSVVAATVLSVTATLLYVRKRRENSHTLTKKRVFRTISREIKGVKKFSFVELSDATNGFDSSTLIGRGSYGKVYKGILSNKTEVAIKRGEETSLQSEKEFLNEIDLLSRLHHRNLVSLIGYSSDIGEQMLVYEYMPNGNVRDWLSANAADTLSFSMRSHVALGSAKGILYLHTEANPPVIHRDIKTSNILLDCQLHAKVADFGLSRLAPAFGEGDGEPAHVSTVVRGTPGYLDPEYFMTQQLTVRSDVYSFGVVLLELLTGMHPFFEGTHIIREVRTANECGTVLSVADSRMGQCSPDKVKKLAELALWCCEDRPETRPPMSKVVKELEGICQSVREPEMFSETTKLLCSKTSPSSSSVPSPLSLLPGSNLDSGFFHAVKPR
Protein: Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate aldolase) (P00888)
Organism: Escherichia coli (strain K12)
Function: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Interaction partners:
- T-protein
- 3-dehydroquinate synthase
- Bifunctional chorismate mutase/prephenate dehydratase
- Shikimate kinase 2
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
- HTH-type transcriptional regulatory protein TyrR
- Transketolase 1
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Shikimate kinase 1
Sequence:
MQKDALNNVHITDEQVLMTPEQLKAAFPLSLQQEAQIADSRKSISDIIAGRDPRLLVVCGPCSIHDPETALEYARRFKALAAEVSDSLYLVMRVYFEKPRTTVGWKGLINDPHMDGSFDVEAGLQIARKLLLELVNMGLPLATEALDPNSPQYLGDLFSWSAIGARTTESQTHREMASGLSMPVGFKNGTDGSLATAINAMRAAAQPHRFVGINQAGQVALLQTQGNPDGHVILRGGKAPNYSPADVAQCEKEMEQAGLRPSLMVDCSHGNSNKDYRRQPAVAESVVAQIKDGNRSIIGLMIESNIHEGNQSSEQPRSEMKYGVSVTDACISWEMTDALLREIHQDLNGQLTARVA
Protein: Translationally-controlled tumor protein homolog (TCTP) (Microtubule and mitochondria-interacting protein 1) (Translation machinery-associated protein 19) (P35691)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in protein synthesis. Involved in microtubule stabilization.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16806052}. Mitochondrion {ECO:0000269|PubMed:16806052}. Note=After induction of apoptosis or mild oxidative stress, reversibly translocates from the cytoplasm to mitochondria, where it is associated with the outer surface. {ECO:0000269|PubMed:16806052}.
Interaction partners:
- Elongation factor 1-beta
- Small ribosomal subunit protein RACK1
- Elongation factor 1-gamma 2
- Elongation factor 1-gamma 1
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS5
Sequence:
MIIYKDIFSNDELLSDAYDAKLVDDVIYEADCAMVNVGGDNIDIGANPSAEGGDDDVEEGAEMVNNVVHSFRLQQTAFDKKSFLTYIKGYMKAVKAKLQETNPEEVPKFEKGAQTYVKKVIGSFKDWEFFTGESMDPDAMVVMLNYREDGTTPFVAIWKHGIVEEKI
Protein: Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (Q29205)
Organism: Sus scrofa (Pig)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9CXW4}. Cytoplasm {ECO:0000250|UniProtKB:Q9CXW4}.
Interaction partners:
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL30
- Uncharacterized protein.
- Ribosomal protein L24.
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein eL6
Sequence:
MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKHDGIILPGN