wanglab/gogpt-training-data huggingface dataset:
Protein: 52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (Death-associated protein 4) (THAP domain-containing protein 0) (THAP domain-containing protein 12) (O43422)
Organism: Homo sapiens (Human)
Function: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.
Interaction partners:
- THAP domain-containing protein 7
- DnaJ homolog subfamily C member 3
- THAP domain-containing protein 11
- Peroxynitrite isomerase THAP4
- THAP domain-containing protein 1
- THAP domain-containing protein 3
- Interferon-induced, double-stranded RNA-activated protein kinase
Sequence:
MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIDETSEQEQKHKETNNSNAQNPSEEEGEGQDEDILPLTLEEKENKEYLKSLFEILILMGKQNIPLDGHEADEIPEGLFTPDNFQALLECRINSGEEVLRKRFETTAVNTLFCSKTQQRQMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDESHNLREEFIGFLPYEADAEILAVKFHTMITEKWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAIYTLCSSCALNMWLAKSVPVMGVSVALGTIEEVCSFFHRSPQLLLELDNVISVLFQNSKERGKELKEICHSQWTGRHDAFEILVELLQALVLCLDGINSDTNIRWNNYIAGRAFVLCSAVSDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAAGSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAHQGNLESQLTSESYYKETLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTSKSELPTDNSETVENT
Protein: EF-hand domain-containing protein (Q8MPY5)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
Interaction partners:
Sequence:
MEQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNERGEIENVSERPMPCTNKTSPMGVYNCDVKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIERELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEEDEDEMEEEYVDEAERKKRGCCHSVGKFIKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEVIWAEVYGGSFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTMHPYTHFDTFPVALITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAGDMCAVARAMDDLDEECEEEESPFGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFAGTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDPPRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNYFRDGWNRFDFVTVVGSITDALVTEFGGHFVSLGFLRLFRAARLIRLLQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNNFQSFFNAVILLFRCATGEGWQDIMMAAVQGKDCARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEEMDEADEELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYRARKSGTEVGGQGLFGGGLRSLVAAAKAAESQHSSHTPQPPEETTPIIPQHAQQFSAAPTMSAQGSLQQMQGTSSGGGQRPYSLFNSFVDTIKSGKQDGDVTDVQYQSVDQQHEKMNSTGRRLSDMFSKIRRGTSADHNPHQNYSHRFGYSRNRGSRYDETEHLLAQDNRSPSSPRYRSMARASPPSPAERYGHPPRYRTESPPSSRSEYQMSIRDPIIRRNRYNTMEHSRSSHDPQYHQDQQQQQQPHHQQHSQHLQHSHHKTYQNHNQYSRSPIYSDDSSVAESYRREREFRRYQDSTPQDVSEDDDPMPTAVRARRLPLISTMPTHYESAYQPSSYNQHLNDSYGLGTGYQRDYHTSHSHSHHPTSQQQQHQPMYSTSPLISPRSSHSYYTPRSSQYYEIPSPSPDIYPSYRGSASPRRYPTSTVVVAPDREGSSARVIQAQPGSIPLSDSETEDDPRWAIV
Protein: Coiled-coil-helix-coiled-coil-helix domain containing 6 (J3QTA6)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00034476}; Lipid-anchor {ECO:0000256|ARBA:ARBA00034476}.
Interaction partners:
Sequence:
MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLQARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKVRPCLPPRFPRALGGRRGTSI
Protein: T. brucei spp.-specific protein (Q580C9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRSSDLFYLKSFFLFHIPETVCQFPVLPPSTCEQVHMLSTPPPQLLFIILFPPFPYCYVLLLFVSAPCLSHVVSTLNILTSLLFSFFLKTF
Protein: SUMO-activating enzyme subunit (Q8I553)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- SUMO-conjugating enzyme UBC9
- SUMO-activating enzyme subunit 1
- Small ubiquitin-related modifier
- Aspartyl protease
- NEDD8-conjugating enzyme UBC12, putative
- NLI interacting factor-like phosphatase, putative
- Sentrin-specific protease 2, putative
- Ubiquitin-activating enzyme E1, putative
- Ran-specific GTPase-activating protein 1, putative
Sequence:
MHKTIRKLFSDEVCDKIENMKILLVGAGGIGSEFLKNIITIGCKNIDIIDIDTIDITNLNRQFLFKKKDVKKYKSLVAKERALMHKKDLNINAYTFDVCTMKSSDIKKYDYVINALDNIKARKYVNKLCIMEKKVLIEAGSTGYNGQVYPIYYNHTKCYSCEEKPKNKTYAICTIRQTPSLPEHCVAWGRLIFETFFCKNDNETLIDIKNHIEEESKKRNMDKKEIIIFIFNYLFNDTIKELIYLKKDYTTIPIPIHFEWDENIIDLFEDESEHNQNEINIDKLNDNKNNMGDNKYYCNNFKCEEKDREKDDNVLMLSSQNIWDKKKCIEMYIKTFLKLYKYLNINKKEEEYLIFDKDDDECINFITSISNIRMLNFCISQKSKFDIQSIAGNIIPAISSTNAIVASLQAFQLIHVIEYFETLKNKNNKKNNNNNKKNNNNNNNNNNENNVSYCDEEENKTDHFNIRNSKAKHVWVKSIVNGNKIFSRGNLVNAEPLEIPNPNCYICQQPTIHIYIKNFEKMTLYNFVKDICMNELSFLYPFLDKDDRNIFDYDLFQENDDDYIQNLYASLSYWNIKHDEILLLTDFQNNNDQLEMHLKEDPSLETEYFIQQKNVPSKKRKINYMQVEGNMDTESVKKKRHILSDEHKETNDEKQPTKKRKQDLIKVEEIIIDDEESDNQNVVLID
Protein: HTH-type transcriptional regulator RipA (AraC-type regulator RipA) (Repressor of iron proteins A) (RIPA) (Q8NRR3)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Function: Under iron limitation, RipA negatively controls the expression of the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes. Binds to the consensus sequence in the promoter region.
Interaction partners:
- Diphtheria toxin repressor
- ABC-type transporter, periplasmic component
- ABC-type transporter, permease components
- ABC-type Fe3+-siderophores transport systems, periplasmic components
- Predicted Na+-dependent transporter
- ABC-type Fe3+-siderophores transport systems, periplasmic components
- Siderophore-interacting protein
- ABC-type transporter, permease components
- ABC-type transporter, permease components
- Hypothetical membrane protein
Sequence:
MSSASLLWCHSGVSTVRFGERIFTLVAGDLLFAPEEAQVADDSQGLVLNIRFETLNIMGPARRIHLGHVWNDRLTFEYSRSLFGKETLSPDIARLFTDRVPTPPLPAPRKARAVAQVLVSNPADQTSLEEFAEIQGVSARTLQRQFLKSTGYSFSEWRAAQRVCVAASLLAHDFSISVVANLVGFAATSSLTRAFRRHTGATPSTFTTGQIGMGSAGHPPRIPATTTFAEAHQDQQLWIYSGTATVTTPGYCRFMGQGDMVTIPAGTQTRIDVAAGSIAFPVPVGLDEWGMDLTRVVAVNNQQPKPLTILEQSEWSKLSEELLNTPVPVQM
Protein: Sodium channel regulatory subunit beta-1 (Q07699)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17928445, ECO:0000269|PubMed:19710327, ECO:0000269|PubMed:21994374, ECO:0000269|PubMed:29992740, ECO:0000269|PubMed:30190309, ECO:0000305|PubMed:8125980}; Single-pass type I membrane protein {ECO:0000269|PubMed:30190309, ECO:0000305|PubMed:8125980}. Perikaryon {ECO:0000250|UniProtKB:P97952}. Cell projection {ECO:0000250|UniProtKB:P97952}. Cell projection, axon {ECO:0000250|UniProtKB:Q00954}. Note=Detected at nodes of Ranvier on the sciatic nerve. {ECO:0000250|UniProtKB:Q00954}.; SUBCELLULAR LOCATION: [Isoform 2]: Perikaryon {ECO:0000269|PubMed:14622265}. Cell projection {ECO:0000269|PubMed:14622265}. Secreted {ECO:0000269|PubMed:21994374}. Note=Detected on Purkinje cells and their cell projections and on neuronal cell projections. {ECO:0000269|PubMed:14622265}.
Interaction partners:
- Sodium channel regulatory subunit beta-2
- Sodium channel protein type 4 subunit alpha
- Sodium channel protein type 5 subunit alpha
- Sodium channel protein type 9 subunit alpha
- Sodium channel protein type 3 subunit alpha
- Sodium channel regulatory subunit beta-4
- Sodium channel protein type 1 subunit alpha
- Sodium channel protein type 2 subunit alpha
- Sodium channel protein type 7 subunit alpha
- Sodium channel protein type 8 subunit alpha
Sequence:
MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
Protein: Prostate androgen-regulated mucin-like protein 1 (PARM-1) (Q6UWI2)
Organism: Homo sapiens (Human)
Function: May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18027867}; Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}. Golgi apparatus membrane {ECO:0000269|PubMed:18027867}; Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}. Endosome membrane {ECO:0000269|PubMed:18027867}; Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}.
Interaction partners:
Sequence:
MVYKTLFALCILTAGWRVQSLPTSAPLSVSLPTNIVPPTTIWTSSPQNTDADTASPSNGTHNNSVLPVTASAPTSLLPKNISIESREEEITSPGSNWEGTNTDPSPSGFSSTSGGVHLTTTLEEHSSGTPEAGVAATLSQSAAEPPTLISPQAPASSPSSLSTSPPEVFSASVTTNHSSTVTSTQPTGAPTAPESPTEESSSDHTPTSHATAEPVPQEKTPPTTVSGKVMCELIDMETTTTFPRVIMQEVEHALSSGSIAAITVTVIAVVLLVFGVAAYLKIRHSSYGRLLDDHDYGSWGNYNNPLYDDS
Protein: Neogenin 1 (Neogenin homolog 1 variant) (Q59FP8)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
GNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA
Protein: phosphatidate phosphatase (EC 3.1.3.4) (I0E2I4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNSLARVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPVDIQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDKHTDNTLERRNLSEKLKEFTTQKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQIKPDVNLTTVTTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNIDEGDAPISSATNNNNTSSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPRLDLDIHFFSDTEITTPVGGGGAGSGRAAGGRPSTPIQSDSELETTMRDNRHVVTEESTASWKWGELPTPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIYLSDLDAGSMDPEMAALYFPSPLSKAASPPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNNRYLDFVAMSMCGMSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYTWMAACPIVMTMITFQKPLTHDAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQDAAPNHLNNTHGMPLGKDEKDGDQAAVATQTSRPTSPDITDPTLSKSDSLVNAENTSALVDNLEELTMASNKSDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVISDIDGTITKSDVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYLRSIRQGNVMLPDGPLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDLFPDKEPFYAGYGNRINDVWAYRAVGIPIMRIFTINTKGELKHELTQTFQSSGYINQSLEVDEYFPLLTNQDEFDYRTDIFDDEESEEELQFSDDYDVDVEHGSSEESSGDEDDDEALYNDDFANDDNGIQAVVASGDERTADVGLIMRVRRVSTKNEVIMASPPKWINS
Protein: Activator of SUMO 1 (CG12276 protein) (CG12276-PA) (LD33652p) (Q7KSM5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- SUMO-activating enzyme subunit
- Dorsal interacting protein 4
- Small ubiquitin-related modifier
- Suppressor of variegation 2-10, isoform I
- Nedd8-conjugating enzyme UbcE2M
- DNA repair protein Rad60
- GH15225p
- E3 SUMO-protein ligase RanBP2
- Ubiquitin-like protein NEDD8
- Molybdopterin synthase catalytic subunit
Sequence:
MVVDMDTSETAVELTEAENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFDVVVVNGATNEELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVANSEKKKKYETVSIPTQRDVDYPGYSAWLDFDVTEPSYLRKLKRNGPGVLLLSVLQKFRTTHKRDPSYKTREADLELLRGIRDELLPNSILGDEALGLIFAQISPAVAVVGGVVAQEVIKVVTKLEAPHRNLFVFDPETCAGYVEAIGAK
Protein: Popeye domain-containing protein 1 (Popeye protein 1) (Blood vessel epicardial substance) (mBVES) (Q9ES83)
Organism: Mus musculus (Mouse)
Function: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.
Subcellular location: Lateral cell membrane {ECO:0000250|UniProtKB:Q8NE79}. Cell junction, tight junction {ECO:0000269|PubMed:16188940}. Membrane {ECO:0000269|PubMed:22354168}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000269|PubMed:24066022}. Membrane, caveola {ECO:0000269|PubMed:24066022}. Note=Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Detected at cell-cell contact but never observed at the free surface of epithelial cells (By similarity). Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle. {ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:20057356}.
Interaction partners:
- Tight junction protein 1
- Rho guanine nucleotide exchange factor 25
- Potassium channel subfamily K member 2
- Protein NDRG4
Sequence:
MNSTESIPLAQSTVAGFTSELESLTPVPSNETTCENWREIHHLVFHVANVCFAVGLLIPTTLHLHMILLRVMLSLGCTLYVVWATLYRCALDVMIWNSVFLGINILHLSYLLYKKRPVKIEKELGGVYHRLFEPLRVPPDLFRRLTGQFCMIQTLKRGQVYATEDKTSVDDRLSILLKGRMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIVADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKVKKLEPQMSLCTQISMLEMRNSITSSSDGEDGLHHFLRGSSSTASLPMSSPQQRASAKMKPIEEGVEDDDEVFVSPDALKVHQLP
Protein: Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B) (P42772)
Organism: Homo sapiens (Human)
Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9230210}. Note=Also found in the nucleus.
Interaction partners:
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase 6
- G1/S-specific cyclin-D1
- Myc proto-oncogene protein
- G1/S-specific cyclin-D2
- Cyclin-dependent kinase inhibitor 2A
- G1/S-specific cyclin-D3
- Cyclin-dependent kinase inhibitor 1
- Cellular tumor antigen p53
- Cyclin-dependent kinase inhibitor 1B
Sequence:
MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD
Protein: Coproporphyrinogen-III oxidase 2, chloroplastic (AtCPO-II) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) (Q93Z96)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity).
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Uroporphyrinogen decarboxylase 1, chloroplastic
- Uroporphyrinogen decarboxylase 2, chloroplastic
- Protoporphyrinogen oxidase 2, chloroplastic/mitochondrial
- Protoporphyrinogen oxidase 1, chloroplastic
- Uroporphyrinogen-III synthase, chloroplastic
- Porphobilinogen deaminase, chloroplastic
- Coproporphyrinogen-III oxidase 1, chloroplastic
- Glutamyl-tRNA reductase 2, chloroplastic
- Magnesium-chelatase subunit ChlH, chloroplastic
- Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic
Sequence:
MASHSSTLFTSPSSFILFSSHRLKSSPNYFTYHFPRSVKRPHFDLRCSVSIEKEVPETERPFTFLRVSDGDQTQSSSYSVRARFEKMIRTAQDKVCEAIEAVEEGPKFKEDVWSRPGGGGGISRILQDGNVWEKAGVNVSVIYGVMPPEAYRAAKAATSEQKPGPIPFFAAGTSSVLHPQNPFAPTLHFNYRYFETDAPKDVPGAPRQWWFGGGTDFTPAYIFEEDVKHFHSV
Protein: Nimrod C1, isoform B (Nimrod C1, isoform C) (M9PBB4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Hemolectin, isoform A
- Atilla, isoform B
Sequence:
MDFTAFSLHFVCLSLSFGTSFAILRHGLNDCSHPESVPYNRKVLKSKLVPFQQYSYFHGWVTKYRHQYVYEDETAYRTVMRPSCCEGYEGSVENCKPVCRQQCPQHGFCSSPNTCSCNAGYGGIDCHPVCPTVCGKNEFCDRPGVCSCQNGYKRTSPSDNCLPVCEKECGHHSFCSEPGKCECEPGYEKVGNGTVFPDGYKNNSNGNCSPICPKDCGQNSRCVRPGVCECENGYAGDDGGTNCRPVCSTCPENGLCLSPGVCVCKPGYVMRNDLCQPHCEKCSDNAHCVAPNQCECFPGYESSGADKKCVPKCSKGCTNGFCFAPETCVCSIGYQMGPNQVCEPKCSLNCVHGKCTSPETCTCDPGYRFKDNSHHECDPICDSGCSNGHCVAPNFCICHDGYQLNSTNPVTSMCQPICKGCQFGDCVAPNVCECNVGYENINGLCELQTTTDSYEYSTTTVELQSSTVDPQLQTSTSEVPHSNCTAGCMCWIEYDGMGTFNTAKCAKICVDPQDKPCLNLDNCQCDLSSGQLVCQEDSDMDYSGENSRYVCHILPEQGARSEAEVRIPDRTGSSNKWMIIVGSCAGMIIGVAATIIGIKYYRRSTSRRNFEAEEAIVECDFE
Protein: Menaquinone reductase (MK reductase) (EC 1.3.99.38) (A0QRI8)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Catalyzes the reduction of a single double bond in the isoprenoid tail of menaquinone (MK-9) in M.smegmatis, likely the beta-isoprene unit, forming the predominant form of menaquinone found in mycobacteria, MK-9(II-H2).
Interaction partners:
- Bifunctional short chain isoprenyl diphosphate synthase
Sequence:
MNTRADVVVVGAGPAGSAAAAWAARAGRDVVVVDAAQFPRDKACGDGLTPRAVAELQRLGMASWLDTRIRHHGLRMSGFGADVEIPWPGPSFPATSSAVPRTELDDRIRSVAADDGAKMMLGTKVVDVTHDSSGRVDAVVLDDGNTVGCAQLIVADGARSTLGRVLGRTWHRETVYGVAIRGYIASPRASEPWITSHLELRSPEGKVLPGYGWMFPLGNGEVNIGVGALATAKRPADAALRPLMSYYADLRREEWGLVGEPRAGLSALLPMGGAVSGVAGPNWMLIGDAAACVNPLNGEGIDYGLETGRLAAELMTSGGVTDYSSAWPTLLQEHYARGFSVARRLALLLTLPRFLQVTGPVAMRSATLMTIAVRVMGNLVTDEDADWIARVWRTAGLASRRIDQRVPFS
Protein: Aryl hydrocarbon receptor nuclear translocator homolog (dARNT) (Hypoxia-inducible factor 1-beta) (Protein tango) (O15945)
Organism: Drosophila melanogaster (Fruit fly)
Function: Heterodimers of tgo/trh are involved in the control of breathless expression. Plays a role in the cellular or tissue response to oxygen deprivation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Spineless, isoform C
- Protein similar
- Dysfusion, isoform D
- Protein single-minded
- Protein trachealess
- histone acetyltransferase
- hypoxia-inducible factor-proline dioxygenase
- Elongin-C
- Cullin-2
- POU domain protein CF1A
Sequence:
MDEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNSSGKTMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSPTPVAPNSWAALRPQQQQQQQQPVTEGYQYQQTSPARSPSGPTYTQLSAGNGNRQQAQPGAYQAGPPPPPNAPGMWDWQQAGGHPHPPHPTAHPHHPHAHPGGPAGAGQPQGQEFSDMLQMLDHTPTTFEDLNINMFSTPFE
Protein: Ribonuclease PH (RNase PH) (EC 2.7.7.56) (tRNA nucleotidyltransferase) (P9WGZ7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
Interaction partners:
- dITP/XTP pyrophosphatase
- Conserved hypothetical alanine rich protein
- ATP-dependent RNA helicase DeaD
- RNA helicase
- Uncharacterized protein Rv1339
- Small ribosomal subunit protein bS1
- Small ribosomal subunit protein uS4
- Endoribonuclease YbeY
- Small ribosomal subunit protein uS11
- Polyribonucleotide nucleotidyltransferase
Sequence:
MSKREDGRLDHELRPVIITRGFTENPAGSVLIEFGHTKVLCTASVTEGVPRWRKATGLGWLTAEYAMLPSATHSRSDRESVRGRLSGRTQEISRLIGRSLRACIDLAALGENTIAIDCDVLQADGGTRTAAITGAYVALADAVTYLSAAGKLSDPRPLSCAIAAVSVGVVDGRIRVDLPYEEDSRAEVDMNVVATDTGTLVEIQGTGEGATFARSTLDKLLDMALGACDTLFAAQRDALALPYPGVLPQGPPPPKAFGT
Protein: BPS1-like protein (Expressed protein) (O82360)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM7
- Cell division cycle 45
- Origin of replication complex subunit 2
- DNA polymerase epsilon subunit B
- Minichromosome maintenance 10
- Origin of replication complex subunit 5
- DNA replication licensing factor MCM6
Sequence:
MSRPQDPPRGFFPFGNPFRMLSSKGSDLSPWLLSLLNGFELRLEERLKKLMPKNKDDILTLSWMKLAMESLCETHKNINTLITDLQLPVSDWEEKWVDVYLNISVRLLDLCNAFSSELTRLNQGDLFLKCVLHNLQSDSGEKYLQARSSLDSWRQHVNTNNPRIENCRAVLDSLVKSLSLPKVKNSPKGKVLMRAFYGVKVQTVYICSVFTAAWSDSTKDLFDLPVSEKPLWAKVFTDMQSVVNAEIRDMLSSGRTTILKELESVDASVEKLYPMIQDGVDPVEVEFFKDNVMELGTQAEKLSQGLDQLLEEVDSFFKLTLRGRDVLLCNLRSSDSISGNAVGEDVD