wanglab/gogpt-training-data huggingface dataset:
Protein: COG4 transport protein middle alpha-helical bundle domain-containing protein (Q57XU9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
NSLDDRVEFLLRRVAKLTEQRQHIAQDIARSVIADGGSLSSSIEEIKAVSYGLLPQFADRGAGLARHIAISASLAESSSRRVKQLDFLLSRVRAARMVADSLQEMRRSVIAVQTMIDRDELESAVQLIRKYEEASGKLGGRSVSARILLREEEGEDEHGEEVVSGVEEEEEEEEEVQPAVKLSSDEQMEERKETVSAVTVGETLQTQGIGDEGGVLASTSSTAGGHETAAEPRVKAAAKMRRKGTWKKGSSGCDEYGGRAAHNDNDVTANRGEVDDEVDRIIVNARQTVREKLMKRFYSAKVVNDKQTIMDTVRLLTLLGFRDECCCMYCSWMCEHTIVALNKMVERELRKIDDPNEAGMSHLALVSAGLDLVVATFENEEEFVLETFGDAGLLLLLTELHSRSTSQCVPVLKDFLKKRQEVLQAVDCTNNSPSPRGESNDNSGRSAVTSPRQPRALQSRGTTLDPRRTDQILEEMSHLVSCYHLYWTFAQSKQQECTQRVREKEGGAREQNDGMNQSADSLWSSRDNPLMTAVQEILAIFVPLQTHYFEAAFHQVLQIQLDAINASSHEHPMPSTTAAVTAGNNSTKQQVGYGSTTSNKAAATLMTGLAAAIYNSTTSGSSANTGGNDASGMVGALVNSSVSGAGNNSGIAVIDEDFLSSTSSQQLAPITLPDDVFYFLRISLHRAVNTKSTQIISAVFIACGELVQSQLIPTLNRYTALPHTTQLQKLQTVHQQRAQQQQGHNYLYTVPTRILRWTAATQCTITYIRRFADELRQLSRSQFSGKDVLRFSEQADDMDGTARELSTGIQQKLEDYAERCYQAHLARHIEPFATLSYEMTEDVFYQYELSDPWVQAFIAAADAALAHFDTYLDPRSFDLLLLALVKRVVSVARSLLLRKSISAYGALQVDREVRTFRTFFTGRAHEEQLREPFIQLMDMTALLLLDHPREAEQKQDQKAFQGGGFIYGGNELTPDEKRRVLRCRVEFKQEDIDRLRL
Protein: Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha) (Q9GQ89)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
Sequence:
MAKDFDVVKYFLQLLDEDKDLSSGIAAIRTLLMILEKKQFGTIHILHTTMREAVAAMRNTDLSIAAIVSAGELFCRFITLSLDDKHMEECRQIMLNRGKIFLTKLLNSRQVIAQQAQRFITDGCRILTHSRSRVVLKALITASQNKKSFHVYVTQGGTGNSGEEMVKDLHAAGIDCTLILDSATGYVMESVDFVLVGAEAVVESGGIINRIGTYTMGLCAREMKKPFYVLAESFKFSRLYPLNQRDLPNEYKYSRKHLNDVSKVHPLVDYTPPVYITLLFTDLGRLTPSAVSDELIKLYM
Protein: GST-containing FLYWCH zinc-finger protein, isoform D (EC 2.5.1.18) (RE40740p1) (Q8INS9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKLYAVSDGPPSLAVRMTLKALDIQYQLINVDFCAMEHRSEEYSKMNPQKEIPVLDDDGFYLSESIAIMQYLCDKYAPDSTLYPQDVNVRAVINQRLCFNMGFYYAPISAHSMAPIFFDYKRTPMSLKKVQNALDVFETYLQRLGTKYAAGENITIADFALISATICLEAINFDLHQFTLVNKWYETFKVEYPQLWEIANSGMQEISAFEQNPPDMSHMEHPFHPTRKSMGLKL
Protein: Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) (P62994)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P62993}. Cytoplasm {ECO:0000250|UniProtKB:P62993}. Endosome {ECO:0000250|UniProtKB:P62993}. Golgi apparatus {ECO:0000250|UniProtKB:Q60631}.
Interaction partners:
- SOS Ras/Rac guanine nucleotide exchange factor 1
- GRB2-associated-binding protein 1.
- E3 ubiquitin-protein ligase CBL
- Receptor protein-tyrosine kinase
- Tyrosine-protein phosphatase non-receptor type 11
- Fibroblast growth factor receptor substrate 2.
- SHC-transforming protein 1
- SOS Ras/Rho guanine nucleotide exchange factor 2
- Lymphocyte cytosolic protein 2
- Insulin receptor substrate 1
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Protein: AP-1 complex subunit gamma (Q7ZUU8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00029433}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFGEEDNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQYVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLSEKNHGVLHTSVVLLTEMCERSPDMLSHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGKGDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAVNILGRFLLNNDKNIRYVALTSLLKTVQADHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCDPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDSVPNLIQLITNSVEMHAYTVQRLYKALLDDISQQPLVQVASWCIGEYGDLLVSGQCEEEEPIQVSEDEVLDVLEGLLVSNLSAPVTRGYSLTAIMKLSTRFSSVNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRPALLERMPIMEKSATNGPAEIVQTNGETDAPILDTKHPPNIPQPISQANDLLDLLGGNDVVPVIQTTAPTKPASAGGELLDLLGDLSLTGGPAPTPAPSVPMSQPPFLLDGLTSQPLFNDIGAGIPPMTAYNKNGLKIEFTFERSNPNPNIAVITIHATNTTEVDMTEFVFQAAVPKTFQLQLLSPSSNVVPALNQGSVTQVIRVLNPQKQQLRMRIKLTYTHKGSPVQDLAEVNNFPPQSWQ
Protein: Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) (O88456)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development.
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.
Interaction partners:
- Calpain-2 catalytic subunit
- Calpain-1 catalytic subunit
- Calpastatin
- Calpain-6
- Calpain-5
- Calpain-10
- Calpain-8
- Calpain-7
- Caspase-3
- Calpain-15
Sequence:
MFLVNSFLKGGGGGGGGGGLGGGLGNVLGGLISGAAGGGGGGGGGMGLGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRSHYSNIEANESEEVRQFRKLFVQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKRFDTDRSGTIGSHELPGAFEAAGFHLNEHLYSMIIRRYADESGNMDFDNFISCLVRLDAMFRAFKSLDKNGTGQIQVNIQEWLQLTMYS
Protein: Pre-mRNA-splicing factor NTC20 (PRP19-associated complex protein 20) (Synergistic to PRP19 mutation protein 384) (P38302)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing. As a component of the NTC complex, associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor ISY1
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-splicing factor CLF1
- Pre-mRNA-splicing factor SNT309
- Pre-mRNA-splicing factor CEF1
- Pre-mRNA-splicing factor PRP46
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor CWC2
- Splicing factor YJU2
Sequence:
MPSLRDLSLERDQELNQLRARINQLGKTGKEEANDFVGLNISNEPVYDTVIQTGQSSNATNSFVQETIQKTKQKESGQPYIIPQKNEHQRYIDKVCETSDLKAKLAPIMEVLEKKTNEKIKGIIRKRVLQEPDRDNDDSG
Protein: Large ribosomal subunit protein eL19 (60S ribosomal protein L19-A) (A0A1D8PK40)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPL19A may play a role in the last stages of translation initiation, in particular subunit joining and shedding/releasing factors (By similarity).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:35613268}.
Interaction partners:
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein uL30
- Small ribosomal subunit protein eS6
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein eS17
- Large ribosomal subunit protein uL1
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein uL13
Sequence:
MANLRTQKRLAASVIGVGKRKVWLDPNETTEIANANSRSAIRKLYKNGTIVKKPETVHSRSRARALKESKRAGRHMGYGKRKGTKDARMPSQVLWMRRLRVLRKLLAKYRDAGKIDKHLYHNLYKAAKGNTFKHKRSLVEHIIAAKAEALREKALKEEAEARRVRNRAARERRQQRLAEKKEALFAEAAN
Protein: Mitochondrial oxaloacetate transport protein (Q9UTN1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transports oxaloacetate and sulfate.
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein.
Interaction partners:
- Mitochondrial tRNA-specific 2-thiouridylase 1
Sequence:
MSEKQTIKALPAHNPTQVKKLGPVSGFLSGGLAACGAVTLTNPFEVIKTRFQLQGQLTKLDPSKRIYKSVGQAFSLIARHEGIRGLQRGLGTAYVYQICLNGCRLGFYEPIRRTLNTWFLDDPKGNKLAINVASGAGSGLCGALFGSPFFLVKTRMQSYSPKFPVGQQYGYKHIFNAFSRIIKENGVKGLFVGADAAILRTVSGSSVQLPIYNWAKRMIEHYNLLEEGMIKHLTASAVSGFGVCCTMQIFDTVMTRMYNQKNKELYKNPIDCILKTIRSEGFFALYKGFGAHLARIAPHTIFCLTFVEQTNKLFLKFQKD
Protein: cDNA FLJ20748 fis, clone HEP05772 (Q9NWL9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMGICPSCALWGMKSCSSCSFPFPLRGGGWGCQGSTLGGGCWGCQGSTLCSLGRGKEAPPCMLCRGPCRPLCLRGRRRGPLGKCAHTHTHTHTHTRTCTHARMHTHTHICAGVQPKSVEPGLAAQLGLPHSWSPQGMSLRIHFVPCF
Protein: 60S ribosome subunit biogenesis protein NIP7 homolog (Q389E3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Nucleolar protein, putative
- Ribosome biogenesis protein, putative
- Ribosome assembly factor mrt4
- Pescadillo homolog
- RNA-binding protein, putative
- rRNA processing protein, putative
- Ribosome biogenesis protein NSA2 homolog
- NLE domain-containing protein
- Nucleolar GTP-binding protein 1
- RNA processing factor 1, putative
Sequence:
MRPLTEEETKKLFDKLAQYIGPNTAHLLQQKGTKSAGVAPFNNGKTTGNNGSNDDDDGDDGEEQNSQQTYVFRLHKNRIWYMPLRLAKLASCVAKSNLMGIGVLFAKVTHHGHVRLQVTALEYIAQYSLFKVWLKPSQEQKFLYGGHVTRAGLGRITEATPRHQKVAVFSMGDVPLGFGVAALGTLECRRCEMNSTVLFHEADVGEYLRNEARLT
Protein: Protein quaking-A (zqk) (Q6P0D0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9QYS9}. Nucleus {ECO:0000250|UniProtKB:Q9QYS9}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 25
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 29
Sequence:
MVGEMEVKERPRPSPDYLMQLLNEKKLMTSLPNLCGIFTHLERLLDEEINRVRKDMYNDSVNGLVDKHPLELPEPVGPIVHLQEKLFVPVKEYPDYNFVGRILGPRGLTAKQLEAETGCKIMVRGRSSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDTQTRAEIKMRRAVEEVKKLLVPAAEGEDNLKKMQLMELAILNGTYRDTNIKAPTLAFSLAAAAAAAQGPRLIAAPPGQVLPPATLRPPTPAGTPIMNIIRPTQMATVLPNGTPTLVPPTPDAGIIYTTPYDYPYALAPTSLLEYPIEHSGVLGAMATKVRRHDSRVHPYQRIVTADRAATGN
Protein: White-opaque regulator 2 (Q5ANB1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- White-opaque regulator 1
- White-opaque regulator 3
- Wor4p
- Enhanced filamentous growth protein 1
Sequence:
MTQLPSVSELINRTGSIGSSSNITRVPPMTTTSATNTTTAATATTVTSTTPRSENSYSPNSPYSLPTRPSNTSLTNYSAGSGITVASSSFQFSQPSPGRSKHNSTSSQSSSGDSFQQHQSNPSGVSMSSNTSPRTSIVQSMSSVPTPPSTGPAPQQFVYQESQLPVQPPPQQQQLQQPPPPPPQQQQHIYPQQQPNFPYHNNFVSPPTYTTAYPQYYYQPVMTPPHHQPHQQAPIHLANNVSILQSQAVMQNAYPTTHYLQHVGPHHIYANVNSQVYYQDMAREEANKALINKRRIIKRRTRTGCLTCRKRRIKCDERKPTCFNCERSKKSCLGYQDLSKLPPRKRNRDTSLDLPDGNQQQQQQQQNQQSIVGGAGNVSDEPHNETHQITSISGSSTNSRNLDMMIPQSFRNNISSQPINFYGPVATTASGASAVINRVSVADLLK
Protein: DnaJ homolog subfamily C member 14 (Dopamine receptor-interacting protein of 78 kDa) (DRiP78) (Q5XIX0)
Organism: Rattus norvegicus (Rat)
Function: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11331877}; Multi-pass membrane protein {ECO:0000269|PubMed:11331877}.
Interaction partners:
Sequence:
MAQKHPGERGLCGVHHSGGSSLITSGSSVDPEILSFSGLRDSKETAPNGTRCLKEHSDPKCTQPPNPAHWSDPSHGPPRGPGPPREGGYPDESETCSEESGVDQELSRENETGYQEDGSPSFLPIPSACNCQGSPGVPEGTCSEEGDGSSSSFCHHCTSPALGEDEELEEEYDDEEPLKFPSDFSRVSSGKKPPSRRQRHRFLTKEDVRDSGRRDPKAPGRHRLARKRSQTDKRRGLGLWGVEELCQLGQAGFWWLIELLVLVGEYVETCGYLIYACRKLKGSDLDLFRIWVGVWARRLGGWARVMFQFLSQSFFSVAGLFIRLLRVVGAFLLLALALFLGCLQLGWRFLVGLGDRLGWRGKAAWLFSWLDSPALHHFLTLLKDSRPWQQLVRVIQWGWLELPWVKQRTQRQGTAHVASGRYCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDIELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNPERRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRVPGTSGRQRATPESPPADLQDFLSRIFQVPPGPMSNGNFFAAPHPGPGTTSTSRPNSSVPKGEAKPKRRKKVRRPFQR
Protein: Hsp70 nucleotide exchange factor FES1 (Factor exchange for SSA1 protein 1) (P38260)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in protein translation, propagation of [PSI+] prions, and polyamine tolerance. Functions as a nucleotide exchange factor (NEF), which accelerates the release of ADP, for the cytosolic Hsp70 chaperone SSA1 and the ribosome-associated Hsp70 chaperone SSB1. Required for fully efficient Hsp70-mediated folding of proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12052876, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Heat shock protein homolog SSE1
- HSP70 co-chaperone SNL1
- Heat shock protein homolog SSE2
- Heat shock protein SSA1
- Protein SIS1
- Heat shock protein STI1
- Heat shock protein 42
- Large ribosomal subunit protein uL23
- Heat shock protein SSA2
- Mitochondrial protein import protein MAS5
Sequence:
MEKLLQWSIANSQGDKEAMARAGQPDPKLLQQLFGGGGPDDPTLMKESMAVIMNPEVDLETKLVAFDNFEMLIENLDNANNIENLKLWEPLLDVLVQTKDEELRAAALSIIGTAVQNNLDSQNNFMKYDNGLRSLIEIASDKTKPLDVRTKAFYALSNLIRNHKDISEKFFKLNGLDCIAPVLSDNTAKPKLKMRAIALLTAYLSSVKIDENIISVLRKDGVIESTIECLSDESNLNIIDRVLSFLSHLISSGIKFNEQELHKLNEGYKHIEPLKDRLNEDDYLAVKYVL
Protein: Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) (P17050)
Organism: Homo sapiens (Human)
Function: Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.
Subcellular location: Lysosome {ECO:0000269|PubMed:9741689}.
Interaction partners:
- Beta-hexosaminidase subunit alpha
- Beta-hexosaminidase subunit beta
- UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
- Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
- Beta-1,3-galactosyltransferase 5
- Lysosomal alpha-mannosidase
Sequence:
MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMADRMAQDGWRDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLGIYADMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQGYPKMAAALNATGRPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSVLSILNWFVEHQDILQPVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTDLRTISAQNMDILQNPLMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNFTGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIKNLEMSQQ
Protein: Guanine nucleotide-binding protein alpha-4 subunit (G alpha-4) (P34042)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure.
Interaction partners:
- Latrophilin receptor-like protein A
- Guanine nucleotide-binding protein subunit beta
- Metabotropic glutamate receptor-like protein E
- G-protein alpha subunit family protein
- Cyclic AMP receptor 1
Sequence:
MRFKCFGSEETEQSSKIDKSIETDRRKLRKDVKLLLLGPGESGKSTIFKQMKIIQEDGGYSVEELLEYRAFVYSNCISQMEALLTASAKLNIELEVENKQRAANVLRRTIGNEPWLLLAADIKHLWEDKGIKETYAQKDKHFQLNDSAAYFFDNIDRYMREDFVPNEQDVLRCRVRTTGIQESEFTFDKIRLKIVDVGGQRSQRRKWIHCFDCVTAVIFVAAMSDYDQVLREDESVNRTRESLALFKEIVNCDYFKETPIVLFLNKKDLFKEKLKRVPLQSCFSDYTGPNKYKDAAMFIQSQYLAQGPSPRTIYTHATCAVDTENIKFVFRAVRQTILSQALEHF
Protein: HDC05479 (Q6IGS3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSQILRMLYCLPIWLLLLLRADEANGKGICLYFSEKTASWFSALTICKSLHMCLADLNTEVTLFQMKSKINQDDHEYWFGLNAHDKPTYRYVSNNKSIEYSPHNSKLVNNEGCVYVKQQNDFFKFESAKCREHRRFICTKTDECDGVSMKHGNSKCVITAEERDLVAY
Protein: Uncharacterized protein (Q9W4D8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH14578p
- Boilerman
- GEO12036p1
- GH25257p
- CCDC113/CCDC96 coiled-coil domain-containing protein
- AT10852p
- Carbonic anhydrase
- CG10920-PA
Sequence:
MSKAQQLMARDQQAARTEEEARRKRAEMRQSYGNKFSSINLHRMRQKQTTNAGDVIATKATTMDAAYSKKAPVETNADAPAMPTKKEKDDPSLRRIASSFAHVRDLVSGSTDALPLEDSEDDAREERAEVLIFSQTMPPPDELSVDLPSPGKSEPETEPDLQSQSQFNLESEQQPQPETNSTDIAAAAAAAQIAELSASVMSSKVMLDAPHTESRAFERWQQLGSTVSALFRARRNIDIAESPMAQTRRLREQRELLEAFTRPFLYDAYRRE
Protein: Carotenoid cleavage oxygenase (CCO) (EC 1.13.11.-) (Carotenoid 13,14/15,15'-oxygenase) (P9WPR5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the oxidative cleavage of several carotenoids and apocarotenoids in vitro. In contrast to other carotenoid oxygenases, cleaves substrates at two different sites, namely the central C15-C15' and an excentric double bond at the C13-C14 position, leading to retinal (C20), beta-apo-14'-carotenal (C22) and beta-apo-13-carotenone (C18) from beta-carotene (C40), as well as the corresponding hydroxylated products from zeaxanthin and lutein. Converts beta-apo-10'-carotenal (C27) into beta-apo-13-carotenone (C18) and to minor amounts of beta-apo-15-carotenal (retinal; C20) from the cleavage at the C13-C14 and the C15-C15' double bonds, respectively. Can also cleave beta-apo-8'-carotenal, 3-OH-beta-apo-8'-carotenal and 3-OH-beta-apo-10'-carotenal. Does not use as substrates beta-apocarotenoids that have a chain length shorter than C25. Also cleaves lycopene into apo-13-lycopenone (C18) and apo-15'-lycopenal (acycloretinal, C20). Moreover, is able to cleave 3,3'-dihydroxy-isorenieratene representing aromatic carotenoids synthesized by other mycobacteria. Might be involved in the utilization of carotenoids from host cells to produce compounds required for normal growth.
Interaction partners:
- Conserved protein
- Uncharacterized protein Rv0887c
- Possible transcriptional regulatory protein
- Probable ribonucleotide transport ATP-binding protein mkl
Sequence:
MTTAQAAESQNPYLEGFLAPVSTEVTATDLPVTGRIPEHLDGRYLRNGPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWYRNRWVRTPAVCAALGEPISARPHPRTGIIEGGPNTNVLTHAGRTLALVEAGVVNYELTDELDTVGPCDFDGTLHGGYTAHPQRDPHTGELHAVSYSFARGHRVQYSVIGTDGHARRTVDIEVAGSPMMHSFSLTDNYVVIYDLPVTFDPMQVVPASVPRWLQRPARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYAWNPSYPARVGVMPREGGNEDVRWFDIEPCYVYHPLNAYSECRNGAEVLVLDVVRYSRMFDRDRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQEFPRINETLVGGPHRFAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTVASLDPDLLIGEMVFVPNPSARAEDDGILMGYGWHRGRDEGQLLLLDAQTLESIATVHLPQRVPMGFHGNWAPTT
Protein: Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (Leucine zipper protein 5) (More than blood protein) (Non-SMC condensin II complex subunit G2) (Q6DFV1)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Condensin-2 complex subunit D3
- Condensin-2 complex subunit H2
- Structural maintenance of chromosomes protein 4
- Condensin complex subunit 1
- Structural maintenance of chromosomes protein 2
- Condensin complex subunit 2
- Non-SMC condensin I complex, subunit G
- Serine/threonine-protein kinase PLK1
- Kinetochore protein Nuf2
- SHC SH2 domain-binding protein 1
Sequence:
MEKREAFIQAVSKELVEEFLQFLQLDKDSSNPFSLSELLDELSRKQKEELWQRLKDLLTETLLESPVDRWQTVEVEGADDMESEHSPKMRKSIKIICAIVTVILASVSIINEHENYGALLECAVILNGILYALPESEQKLQNSIQDLCVKWWERGLPAKEDMGKTAFIMLLRRSLETKSGADVCRLWRIHQALYCFDYDWEESREIKDMLLECFINVNYIKKEEGRRFLSFLFSWNVDFIKMIHETIKNQLAGLQKSLMVHIAEIYFRAWKKASGKMLETIEYDCIQDFMFHGIHLLRRSPVHSKVREVLSYFHQQKVRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRDPNFTATEMDNEIQKQFEELYNLIEDPYPRVRSTGILGVCKISSKYWEMMPPNILVDFLKKVTGELAFDISSADVRCSVFKCLPIILDNKLSHPLLEQLLPTLRYSLHDNSEKVRVAFVDLLLKIKAVRAAKFWKICPMEDILVRLEMDSRPVSRRLVSLIFNSFLPVNQPEEVWCERCVTLIQMNRAAARRFYQYAHEHTASTNIAKLIHVIRHCLNACIQRTLREGSEAHKECEKENASVLDKTLSVNDTASMAGLLEIIVILWKNIHRSLENNKEAKIYTINKFAAVLPEYLKVFKDERCKIPLFMLMSFLPASAVPVFSCGVISVLRNQESVTGRSYCTLLDCLCSWGQVGHVLELIVDWLPTVPPQAKSNLASKRKVEINDTCSVKPELALLYMEYLLTHPKNRECLLSVPQKKLNQLLKALEGSKAELESFLQSPSGNPLNFNKATALHAFGLYCRMSVHLQYKFCSEEKIHLSILDDTGSWLENKVLPLLEDQEEEYLKLRKDVYQQIIQTYLAVCKDVVMVGLGDPKFQMQLLQRSFGIMKTVKGFFYVSLLLGILKEIAGNTIIHKTDSDEKVTVLFDLVQEVFQKMLECIACIFRKQPEESLPLFHSVQTPLHEFITTIQSWHKDTAVHHAVLSTLIAAPVVEISHQLQKVSDIEELTSPQCLHDLPPFSRCLVGVIMKSSDVVRSFVDELKACVTSGDVEGIVCLTAVLHIILVINKGKHISAKVKEVATAVYRKLKTFMEITLEEDSLERFLYESSMRTLGEFLNP
Protein: Palmitoyl-protein thioesterase 1 (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) (A0A2C9F2P4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMDSCCNPLSMGAIKKMVEKKIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAHIIPFLG
Protein: Cell division cycle 25C (D6RD20)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSEEARFCFSPGENSKTMSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKEN