wanglab/gogpt-training-data huggingface dataset:
Protein: Protein SPA1-RELATED 2 (Q9T014)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in suppression of photomorphogenesis in dark-grown seedlings. Probably part of the COP1/SPA E3 ubiquitin-protein ligase complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:15308756}.
Interaction partners:
- Cryptochrome-2
- Cryptochrome-1
- Transcription factor HY5
- Protein SUPPRESSOR OF PHYA-105 1
- Transcription factor HY5-like
- Eukaryotic translation initiation factor 2 subunit alpha homolog
- Eukaryotic translation initiation factor 2 subunit alpha
- Protein DWD HYPERSENSITIVE TO UV-B 1
- Cullin-4
- AT3g05090/T12H1_5
Sequence:
MMDEGSVGDVSRIDEADVAHLQFKNSEQSFKPENIEVREVKEVQVQREAGSPDCSYGVIADFLDGKNGGDHVELIGNEPCSSRQNTNDEGDVVEELTVKTCEGSSMAIVGRPSSRARLEMNRSQFLHRFPLDGDLPGSSSMSKKVIDRGTVSILRNAGKMSLPETSNGQLAIIAVNGEANEHLTNVERNPVPVEALSHEGIKTKMLSQSGFSQFFVRKTLKGKGVTFRGPPNNRSKARNMDQQTVASSGSALVIANTSAKISSSIPLAAYDGLPCLPSNTSKPSSCANPSDTHRGCGGEGLSLREWLKSERQEVNKAECMYIFRQIVDHVDCSHSQGVVLCDLRPSSFKIFKENAVKYVVSGSQRESFDSNMNKETLSQLENPLVRRRLGDTSSLSIPAKKQKSSGPSSRQWPMFQRAGGVNIQTENNDGAIQEFHFRSSQPHCSTVACPFTSVSEQLEEKWYASPEELRGDMRSASSNIYSLGILLYELLSQFQCERAREAAMSDIRHRILPPKFLSENPKEAGFCLWLLHPESSCRPSTRDILQSEVVNGIPDLYAEGLSLSIEQEDTESELLQHFLFLSQEKRQKHAGNLMEEIASVEADIEEIVKRRCAIGPPSLEEASSSSPASSVPEMRLIRNINQLESAYFAARIDAHLPEARYRLRPDRDLLRNSDNTVAEVENSETWSSDDRVGAFFDGLCKYARYSKFETRGVLRTSELNNTSNVICSLGFDRDEDYFATAGVSKKIKIYEFNSLFNESVDIHYPAIEMPNRSKLSGVCWNNYIRNYLASSDYDGIVKLWDVTTGQAISHFIEHEKRAWSVDFSEACPTKLASGSDDCSVKLWNINERNCLGTIRNIANVCCVQFSPQSSHLLAFGSSDFRTYCYDLRNLRTPWCILSGHNKAVSYAKFLDNETLVTASTDNTLKLWDLKKTTHGGLSTNACSLTFGGHTNEKNFVGLSTSDGYIACGSETNEVYAYHRSLPMPITSYKFGSIDPISGKEIEEDNNLFVSSVCWRKRSNMVVSASSNGSIKVLQLV
Protein: Subtilisin-like protease SBT1.9 (EC 3.4.21.-) (Subtilase subfamily 1 member 9) (AtSBT1.9) (Q9FHA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q84WS0}.
Interaction partners:
- BI1-like protein
- Protein LIFEGUARD 3
- Protein LIFEGUARD 1
- Protein DETOXIFICATION 49
- Glycine--tRNA ligase, mitochondrial 1
- RING-H2 finger protein ATL66
- Protein LIFEGUARD 4
- Aminopeptidase P2
Sequence:
MGMTVVIILVFSFFVAIVTAETSPYIIHMDLSAKPLPFSDHRSWFSTTLTSVITNRKPKIIYAYTDSVHGFSAVLTNSELQRLKHKPGYVSFTKDLPVKLHTTFSPKFIGLNSTSGTWPVSNYGAGIVIGIIDTGIWPDSPSFHDDGVGSVPSKWKGACEFNSSSLCNKKLIGAKVFNKGLFANNPDLRETKIGQYSSPYDTIGHGTHVAAIAAGNHVKNASYFSYAQGTASGIAPHAHLAIYKAAWEEGIYSSDVIAAIDQAIRDGVHVISLSLGLSFEDDDDNDGFGLENDPIAVASFAAIQKGVFVVTSGGNDGPYYWSLINGAPWIMTVGAGTIGRQFQGTLTFGNRVSFSFPSLFPGEFPSVQFPVTYIESGSVENKTLANRIVVCNENINIGSKLHQIRSTGAAAVVLITDKLLEEQDTIKFQFPVAFIGSKHRETIESYASSNKNNATAKLEFRKTVIGTKPAPEVGTYSSRGPFTSFPQILKPDILAPGTLILSAWPSVEQITGTRALPLFSGFNLLTGTSMAAPHVAGVAALIKQVHPNWSPSAIKSAIMTTALTLDNPLAVGAGHVSTNKVLNPGLIYDTTPQDFINFLCHEAKQSRKLINIITRSNISDACKKPSPYLNYPSIIAYFTSDQSSPKIFKRTLTNVGEAKRSYIVRVRGLKGLNVVVEPKKLMFSEKNEKLSYTVRLESPRGLQENVVYGLVSWVDEDEAEFEVSCSVVATSLVQES
Protein: NMDA receptor regulated 1-like (cDNA FLJ77538, highly similar to Homo sapiens NMDA receptor regulated 1-like (NARG1L), transcript variant 1, mRNA) (A4FU51)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAEHGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQVPPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEKVSIIQELVTNYEASLKTCDFFSPYENGEKEPPTTLLWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYKHIGNLKEAAKWMDEAQSLDTADRFINSKCAKYMLRANMIKEAEEMCSKFTREGTSAMENLNEMQCMWFQTECISAYQRLGRYGDALKKCHEVERHFFEITDDQFDFHTYCMRKMTLRAYVDLLRLEDILRRHAFYFKAARSAIEIYLKLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQKKKRDEEEEEASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIYFRKGKFLLMLQSVKRAFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKIFVKKDLESFNEDFLKRNATSLQHLLSGAKMMYFLDKSRQEKAIAIATRLDETIKDKDVKTLIKVSEALLDGSFGNCSSQYEEYRMACHNLLPFTSAFLPAVNEVDNPNVALNHTANYDVLANEI
Protein: Insulin-like growth factor-binding protein 1 (M4Q8Z6)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLGLYKKLTLLAAMSLSLLTSLAQSSPVVGPEPIRCAPCTQEKLDECPAISPDCKQVLREPGCGCCLACALEKGASCGVYTAHCAQGLKCSPRPGDPRPLHSLTRGQAICTEDQGQEEVEGVPDHSSLTYFLGLNTPFDTKNEGAQESIKAKVNTIRKKLVEQGPCHIELHAALDKITSSQQELGEKFTNFYLPNCDKHGFYKAKQCESSLVGPPARCWCVFSWNGKKIPGSNYLLGGLECQLEL
Protein: Uncharacterized protein Rv2576c (P9WL83)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MPAGVGNASGSVLDMTSVRTVPSAVALVTFAGAALSGVIPAIARADPVGHQVTYTVTTTSDLMANIRYMSADPPSMAAFNADSSKYMITLHTPIAGGQPLVYTATLANPSQWAIVTASGGLRVNPEFHCEIVVDGQVVVSQDGGSGVQCSTRPW
Protein: Proteasome subunit alpha type-1-B (20S proteasome alpha subunit F-2) (Proteasome component 2B) (Proteasome subunit alpha type-6) (O23712)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May play a role in thiol biosynthesis and arsenic tolerance in association with PAF1/ARS5.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-6
- Proteasome subunit beta type-4
- Proteasome subunit beta type-1
- Proteasome subunit beta type-3-A
- Proteasome subunit beta type-3-B
- Proteasome subunit alpha type-4-A
- Proteasome subunit alpha type-5-B
- Proteasome subunit alpha type-6-B
- Proteasome subunit beta type-2-A
Sequence:
MFRNQYDTDVTTWSPTGRLFQVEYAMEAVKQGSAAIGLRSRSHVVLACVNKAQSELSSHQRKIFKVDDHIGVAIAGLTADGRVLSRYMRSESINHSFTYESPLPVGRLVVHLADKAQVCTQRSWKRPYGVGLLVGGLDESGAHLYYNCPSGNYFEYQAFAIGSRSQAAKTYLERKFESFQESSKEDLIKDAIMAIRETLQGETLKSSLCTVSVLGVDEPFHFLDQESIQKVIDTFEKVPEEEEDAGEGEAEPEAAPGAAGTGEQGGSGDQDVAPMEI
Protein: Putative disease resistance protein At3g14460 (Q9LRR5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential disease resistance protein.
Interaction partners:
- LOW protein: ankyrin repeat protein
- Disease resistance protein RPP2B
- Protein kinase superfamily protein
- At5g50330
- Protein kinase superfamily protein
- Protein kinase superfamily protein
- Early nodulin-like protein 20
- Anthranilate N-hydroxycinnamoyl/benzoyltransferase-like protein
- Putative receptor-like protein kinase At3g47110
- DNAse I-like superfamily protein
Sequence:
MANSYLSSCANVMVERINTSQELVELCKGKSSSALLKRLKVALVTANPVLADADQRAEHVREVKHWLTGIKDAFFQAEDILDELQTEALRRRVVAEAGGLGGLFQNLMAGREAIQKKIEPKMEKVVRLLEHHVKHIEVIGLKEYSETREPQWRQASRSRPDDLPQGRLVGRVEDKLALVNLLLSDDEISIGKPAVISVVGMPGVGKTTLTEIVFNDYRVTEHFEVKMWISAGINFNVFTVTKAVLQDITSSAVNTEDLPSLQIQLKKTLSGKRFLLVLDDFWSESDSEWESFQVAFTDAEEGSKIVLTTRSEIVSTVAKAEKIYQMKLMTNEECWELISRFAFGNISVGSINQELEGIGKRIAEQCKGLPLAARAIASHLRSKPNPDDWYAVSKNFSSYTNSILPVLKLSYDSLPPQLKRCFALCSIFPKGHVFDREELVLLWMAIDLLYQPRSSRRLEDIGNDYLGDLVAQSFFQRLDITMTSFVMHDLMNDLAKAVSGDFCFRLEDDNIPEIPSTTRHFSFSRSQCDASVAFRSICGAEFLRTILPFNSPTSLESLQLTEKVLNPLLNALSGLRILSLSHYQITNLPKSLKGLKLLRYLDLSSTKIKELPEFVCTLCNLQTLLLSNCRDLTSLPKSIAELINLRLLDLVGTPLVEMPPGIKKLRSLQKLSNFVIGRLSGAGLHELKELSHLRGTLRISELQNVAFASEAKDAGLKRKPFLDGLILKWTVKGSGFVPGSFNALACDQKEVLRMLEPHPHLKTFCIESYQGGAFPKWLGDSSFFGITSVTLSSCNLCISLPPVGQLPSLKYLSIEKFNILQKVGLDFFFGENNSRGVPFQSLQILKFYGMPRWDEWICPELEDGIFPCLQKLIIQRCPSLRKKFPEGLPSSTEVTISDCPLRAVSGGENSFRRSLTNIPESPASIPSMSRRELSSPTGNPKSDASTSAQPGFASSSQSNDDNEVTSTSSLSSLPKDRQTEDFDQYETQLGSLPQQFEEPAVISARYSGYISDIPSTLSPYMSRTSLVPDPKNEGSILPGSSSYQYHQYGIKSSVPSPRSSEAIKPSQYDDDETDMEYLKVTDISHLMELPQNLQSLHIDSCDGLTSLPENLTESYPNLHELLIIACHSLESFPGSHPPTTLKTLYIRDCKKLNFTESLQPTRSYSQLEYLFIGSSCSNLVNFPLSLFPKLRSLSIRDCESFKTFSIHAGLGDDRIALESLEIRDCPNLETFPQGGLPTPKLSSMLLSNCKKLQALPEKLFGLTSLLSLFIIKCPEIETIPGGGFPSNLRTLCISLCDKLTPRIEWGLRDLENLRNLEIDGGNEDIESFPEEGLLPKSVFSLRISRFENLKTLNRKGFHDTKAIETMEISGCDKLQISIDEDLPPLSCLRISSCSLLTETFAEVETEFFKVLNIPYVEIDGEIFS
Protein: Kismet, isoform B (Q9VPL6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEVIKPMDFSSFSAFCEHLNKSSQIAATTATTIPPTINNGKGIYLEKMERQGKMELAAKERESQRLQLIPKKWNRREEYEFLRVLTGYGVDLHVSTPMASSNGSSLSPDWTKFKQMAHLERKSDETLTDYYKVFVAMCKRQAGLKLSESERGLEGIIEEIEKEHAKLILDRLEVLAKLREVARNPMLEERLKLCTKNADTPDWWEPGRHDKELITAVLKHGLYRSETFIFNDPNFSFGESEKRFIRELEAQIQRTIKLEAFNAEKAEKLAAAEKDAATEKAAATEKAAAEKAASVKNEVIDLDDELMTNESVIKKESPVTPIKEEIKSEESPEKHDTADNLEDKNSDAEESTKIKGKEDFNPETTEKEALDESTNLNKDKSSTETLVPEIEDSKPSEDKMEVEELPVAENGEKEGSPEKCSDAEDKKFSEEKPSSPAVPDGKVSEMEADEAAPNTEENCSGDSESPEKECEDKVVEKVEEEKGENSYEKAEEQKEETEKLEKSSIESEPSEKSETVLEPEVAVPKKSTGDQDILDLVAGPSDPDDDEVMKEKEKAVEEECKKQAAELKARFPDLEVIQPATVKQQKLEKPKLEMCMIRWFKDFALERRIAHIVACVESGNWPVDSKYSAFATCKGATDLSIALHESIPHLSSLERRSTTPDVITITTDQGVTKHLQTSHMQQVASSASAASTSSGVPQVTQSKPSSSNSLPGLDAKSINAAVAAAVAAAAAGGNATSLSSLLPGMSLSAATGSSAGGVSGLSVPSAGSGVGKKRKRHIAIDVETERAKLHALLNSSTMAPKDWESEIANMEALSGSSGRGRGGNSSASSGMQPPPAHQHASLSRQSSGQFSKPAVPAMKTPPPSMGAPMDLSSSLPKMNMTEMLKSASSSGAIDLSEVQDFSMPSKKSSVHAALSSAFPSMGNKSKLDDTLNKLMKKNNCTIEEPVIGKEKKRKKLDEIVLGLSAAKEQKTFPDPSLPSSKKPQIPPSVSVTPANLQSSSNQQSNQKPFTITVTTVPGKSKSGSSNSGSGTGGSSSASGGGAGGSGLSALQNMAMGGLSSKDSLNALLAQTMATDPQTFLKQQQKMMQFLPPAQRKAYENMLAEMEQAMKISSKFSTNSPHDVKVNKWLSDMTSPLGDQLSIDYVGGGGASGSGSGNSRRSNRQQGNSQQSSSAAQLQKQQQQQQQQQQQQQQHSMPGPQNLTGEEPVPVINKQTGKRLGGNKAPQLKRLMQWLTENPNYEVDPKWLEQMQNPMSTPSPRPASMESGYGSSAVKSHGGRPLSNLSSTSSSSHTQQQSSAAQSQAGGNSGSSKKNSRQQTAASAALDQAALQFGSLAGLNPSLLANLPGLGAFDPKNPLAAFDPKNPLLSMSFGGMPGMGNIPGLGNLNNMNLFASLAGMGGLGNLAGMDTQSLAALMAAAGPTLGGLTGASGGAGSGKSQAQSQSSATSSSSSASKKKQQQQQQQAQNEAAQLAAAISASTGGSGASGGKNAAASASQLAAGFPFLFPNPSLLYPPMGLGGLNPYSLGSSGLGSAYDQLAQQYNLLNGATSSASNTSSTQSKSHQSQSKSSQSRNTTASANSAASLMNAMASMGGGASTVTTPSTSASGSGRGRQSSSRNQSQTTPTAADMAQLSSLLMPGADPHLLESLSRMSNMDLAQATRLMSSLGMPPLSGTPSSSGGGNTSTSKRSSQAANEANVQAKEQQKWLESLARGALPTDLAALQAFSQGKMPSTSGSNTGTSTSSSKSSKAAATAAAAQLPQIPGMSSDFPQAFLAEMAAQAMAAAGGSLPLSGPGSLASLAGLTGGSAGGGGSSASGSTSHSSSKRQREQDAFKQQMDYYTKTLGLGSGISLIPTSSAGGSSASSSAANAAAAAYAAALDAEQQHQQQQKALSKRARGDLHPTKEELAALAAGLPLNLGASMSSIEKSLRGGSSSSSSSTPAPMTAEQDKVTLTPLNASGGGSGSSSSSAAAAGLAANLPSQTTITIAPPISSGASTSSERSERSESRISLTITNAADAAKLPPPYEEADELIIQPILKKPTAANPGSSHGGSVDDLDTAENTSAANLSGSSSSSAAAAAAAAAEENRRSSNRLKRPRSGNEQGSGSVEGQPPEKRRELRSTRHTRSSADASTLNLSTGSESGAEERNE
Protein: Transcriptional regulator NarO (Bacterioopsin transcriptional activator) (DNA-binding protein NarO) (D4GPG1)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: Activates transcription of the denitrifying genes (nitrate reductase narA and nitrite reductase nirK) under anaerobic conditions.
Interaction partners:
Sequence:
MNEGVHGEIHVADPSICRVSEASKETAVESVSRSVGATGDTAAVEFTAPSSAAIDDADEIFHHEQKTIYRVTHSFTEESRCACELIEGHGCPVRHLEADCGAVVLSFVAADLESFRDIVVNLKSAFDGVSLRRLTQSEPDSATGSLVFVDRDELTARQREVLETAHEMGYFEHPREANATEVAAALDINRSTFTEHLSAAQSKLLDTILDV
Protein: Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) (P05024)
Organism: Sus scrofa (Pig)
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8VDN2}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P06685}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P05023}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P06685}. Melanosome {ECO:0000250|UniProtKB:P05023}.
Interaction partners:
- FXYD domain-containing ion transport regulator
- Sodium/potassium-transporting ATPase subunit beta-1
- Protein ATP1B4
- Sodium/potassium-transporting ATPase subunit beta
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Mitogen-activated protein kinase
- Sodium/potassium-transporting ATPase subunit beta
- Mitogen-activated protein kinase
- cGMP-dependent protein kinase
Sequence:
MGKGVGRDKYEPAAVSEHGDKKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWSDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYTKIVEIPFNSTNKYQLSIHKNPNTAEPRHLLVMKGAPERILDRCSSILIHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPLDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPASKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNEQLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVNWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTPFFVTIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
Protein: Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PsmB) (Q58634)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.jannaschii proteasome is able to cleave oligopeptides after Glu, Asp, Tyr, Phe, Trp, slightly after Arg, but not after Ala. Thus, displays caspase-like and chymotrypsin-like activities and low level of trypsin-like activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02113}.
Interaction partners:
- Proteasome subunit alpha
- Proteasome-activating nucleotidase
- Large ribosomal subunit protein eL40
- Tetrahydromethanopterin S-methyltransferase subunit A
- Cell division cycle protein 48 homolog MJ1156
- Uncharacterized protein MJ0106
- Transcription termination factor FttA
- Ribose 1,5-bisphosphate isomerase
Sequence:
MDVMKGTTTVGLICDDAVILATDKRASLGNLVADKEAKKLYKIDDYIAMTIAGSVGDAQAIVRLLIAEAKLYKMRTGRNIPPLACATLLSNILHSSRMFPFLTQIIIGGYDLLEGAKLFSLDPLGGMNEEKTFTATGSGSPIAYGVLEAGYDRDMSVEEGIKLALNALKSAMERDTFSGNGISLAVITKDGVKIFEDEEIEKILDSMKAKPKKKTTKRSRRKSK
Protein: Spindly (Q9VQS4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein zwilch
- Centromere/kinetochore protein zw10
- Dynein light intermediate chain
- Nuclear distribution protein nudE homolog
- Rough deal
- CENP-meta, isoform C
Sequence:
MYKNLDLDTLSVDDIVEEYKLLHDRHQQLKDQSEKDAQRIYELKRNLDTALAAESYLTQELEHLSSQPVAIASGGNGQELEELRRKFKTLKEEQDVLQQDYDAKVEETRSLKDKLTAAEKNLAEKSASRSNQLHDDFFARLNALELENCELLQKLAEYEDLRIANTLAVAEKEKTIECLQDRVSCMEQNLNCKRDELEEKLQLLESCQEQLVDANAKIALLTSAPENNDRKGNSLFAEVDDQRQAMKQILAAQKKSYLDMKKIFTDSQFEIRRLKRENVAMHTELQACSTIFCSADKTYQNKLNERIRQLMTANDSLERQLNLSQERLRQLASEKSVTWLDSMLDFCKRETDELKAQLHSMRIQKAGLEERMRCVQQEMARWRFESLKSRCVLIDRENLLAEHKIVFKPMQAMEFNIKEAELKTALPRIVSVAAQSPSSSAQLHTHPETSLKSAAETTSKSFPTATEIIVLDAPLKPAIKEEVVEPLSQELKPALKDTSVKVEQELEVSESKACIKRTPIKTIMGMKIKREIDLNLEQQDAVDIKKELEAPELIPKPQLKGTPVKAKNDGVTPQMNIQEDENEETGLNSVETPAKPLMKGTPVKQRLGGIKVKSNEELLGARLPGTVTPAKPQRKGTPVKLIKLETETEDSSDEAAKESPIKQDGTLSVEILDSPTPQKPQRKGTPVRIPVIKDSTNENIRSILSKKRQVFAEDSQKAVKFSANDPIVHNLSPLERCPNGETTKENDKPKESEDNQDVKPTIKKPNIIRRIVVSSRKPIMK
Protein: Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) (Q9H9G7)
Organism: Homo sapiens (Human)
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
Subcellular location: Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03032, ECO:0000269|PubMed:16081698}.
Interaction partners:
- Protein argonaute-2
- Endoribonuclease Dicer
- Protein argonaute-1
- Trinucleotide repeat-containing gene 6A protein
- Trinucleotide repeat-containing gene 6C protein
- Trinucleotide repeat-containing gene 6B protein
- RISC-loading complex subunit TARBP2
- Protein argonaute-4
- Ribonuclease 3
- Probable ATP-dependent RNA helicase DDX6
Sequence:
MEIGSAGPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA
Protein: Syntaxin-5 (Q8K1E0)
Organism: Mus musculus (Mouse)
Function: Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q08851}; Single-pass type IV membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q08851}. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000250|UniProtKB:Q08851}.
Interaction partners:
- Golgi SNAP receptor complex member 1
- Vesicle transport through interaction with t-SNAREs homolog 1A
- BET1 homolog
- Vesicle-trafficking protein SEC22b
- BET1-like protein
- Golgi SNAP receptor complex member 2
- Vesicle-associated membrane protein 4
- Synaptobrevin homolog YKT6
- Syntaxin-6
- Sec1 family domain-containing protein 1
Sequence:
MIPRKRYGSKNTDQGVYLGLSKTQVLSPATAISSSSDSTPLPTPVALVPSPPDTMSCRDRTQEFQSACKSLQSRQNGIQTSKPALHAARQCSEFTLMARRIGKDLSNTFAKLEKLTILAKRKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVRAKGSQSGRHLQTHSNTIVVSLQSKLASMSNDFKSVLEVRTENLKQQRNRREQFSRAPVSALPLAPNNLGGGPIILGAESRASRDVAIDMMDPRTSQQLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQEETIQRIDENVLGAQLDVEAAHSEILKYFQSVTSNRWLMVKIFLILIVFFIIFVVFLA
Protein: Uncharacterized protein DKFZp586B2022 (Q9Y423)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
KLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS
Protein: Bet1-like SNARE 1-1 (AtBET11) (Bet1/Sft1-like SNARE 14a) (AtBS14a) (Q9M2J9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE associated with ER-derived vesicles (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
- Syntaxin-31
- Membrin-11
- Syntaxin-32
- Membrin-12
- 25.3 kDa vesicle transport protein SEC22-1
- SNARE-like superfamily protein
- Golgi SNAP receptor complex member 1-1
- Golgi SNAP receptor complex member 1-2
- VAMP-like protein YKT62
- VAMP-like protein YKT61
Sequence:
MNPRREPRGGRSSLFDGIEEGGIRAASSYSHEINEHENERALEGLQDRVILLKRLSGDINEEVDTHNRMLDRMGNDMDSSRGFLSGTMDRFKTVFETKSSRRMLTLVASFVGLFLVIYYLTR
Protein: Mitogen-activated protein kinase 3 (AtMPK3) (MAP kinase 3) (EC 2.7.11.24) (Q39023)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in oxidative stress-mediated signaling cascade (such as ozone). Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in hypersensitive response (HR)-mediated signaling cascade by modulating LIP5 phosphorylation and subsequent multivesicular bodies (MVBs) trafficking. May phosphorylate regulators of WRKY transcription factors. Mediates the phosphorylation of VIP1 and subsequent stress genes transcription in response to Agrobacterium. MKK9-MPK3/MPK6 module phosphorylates and activates EIN3, leading to the promotion of EIN3-mediated transcription in ethylene signaling. MPK3/MPK6 cascade regulates camalexin synthesis through transcriptional regulation of the biosynthetic genes after pathogen infection. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. When activated, reinforces the feedback loop by phosphorylating BASL, and inhibits stomatal fate by phosphorylating SPCH. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the morphology of plant organs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15500467}. Nucleus {ECO:0000269|PubMed:15500467, ECO:0000269|PubMed:31235876}. Cytoplasm, cell cortex {ECO:0000269|PubMed:25843888}. Note=Translocated into the nucleus in response to phosphorylation (Probable). Recruited by BASL at the cell cortex in a polarized manner (PubMed:25843888). {ECO:0000269|PubMed:25843888, ECO:0000305}.
Interaction partners:
- Dual specificity protein phosphatase 1B
- Mitogen-activated protein kinase kinase 4
- Nucleoside diphosphate kinase II, chloroplastic
- 1-aminocyclopropane-1-carboxylate synthase 6
- Transcription factor VIP1
- 1-aminocyclopropane-1-carboxylate synthase 2
- Transcription factor SPEECHLESS
- Protein ETHYLENE INSENSITIVE 3
- Mitogen-activated protein kinase kinase 9
- Mitogen-activated protein kinase kinase 5
Sequence:
MNTGGGQYTDFPAVETHGGQFISYDIFGSLFEITSKYRPPIIPIGRGAYGIVCSVLDTETNELVAMKKIANAFDNHMDAKRTLREIKLLRHLDHENIIAIRDVVPPPLRRQFSDVYISTELMDTDLHQIIRSNQSLSEEHCQYFLYQLLRGLKYIHSANIIHRDLKPSNLLLNANCDLKICDFGLARPTSENDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMNRKPLFPGKDHVHQMRLLTELLGTPTESDLGFTHNEDAKRYIRQLPNFPRQPLAKLFSHVNPMAIDLVDRMLTFDPNRRITVEQALNHQYLAKLHDPNDEPICQKPFSFEFEQQPLDEEQIKEMIYQEAIALNPTYG
Protein: Tubulin alpha 1c (F8VS66)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLVSIVL