wanglab/gogpt-training-data huggingface dataset:
Protein: UmuC domain-containing protein (C1F6L3)
Organism: Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)
Interaction partners:
- Beta sliding clamp
- DNA-directed DNA polymerase
- Protein RecA
- Pyruvate ferrodoxin oxidoreductase
Sequence:
MSNTHEIYACLYVPEFPAQAVLRLRPDLQDRACVVMEGTAPAEQVIACNRRARQLGVACGMTRVDVELFPHITPLARSHAMEDATAAAVLECASSFSPRVEVLSTGTALICALDIAGTQTLFGPPEILARNLHERLRTIGMEARITASANLHAAVCMARGMRPADRVAILPRGKEASLLAPLPVDVLALSSDQAETFALWGIRTLGMLATLPKEALVARMGQAAKRLHALARGEWPHLLQPIQAPFQLIEKVEFDAPIDALESLLFVLNTMLDQLIERARARMLVLATVTVTLSLEGGAMATNTVRPALPTSDKPLWLKLLQLELEAHPPEASMIGITMQAEPGVSSKVQMGLFSPQTPDASRLDVTLARLRALVGEDHVGRAMIEDSPAPDRFHMEPFSVAPSPAKTHEPERILLPRLTLRRLRPPEPARVTVRQSQPAEIFFREQKYIVDRVYGPWKIDGEWWTSTLWGEEQWDVVLRSMSGGLLCACLVRDCMQNHWHMAALYD
Protein: Subtilisin-like protease (p69B protein) (O04678)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MGLLKILLVFIFCSFQWPTIQSNLETYIVHVESPESLVTTQSLLTDLGSYYLSFLPKTATTISSSGNEEAATMIYSYHNVMTGFAARLTAEQVKEMEKKHGFVSAQKQRILSLHTTHTPSFLGLQQNMGVWKDSNYGKGVIIGVIDTGIIPDHPSFSDVGMPPPPAKWKGVCESNFTNKCNNKLIGARSYQLGNGSPIDSIGHGTHTASTAAGAFVKGANVYGNADGTAVGVAPLAHIAIYKVCNSVGCSESDVLAAMDSAIDDGVDILSMSLSGGPIPFHRDNIAIGAYSATERGILVSCSAGNSGPSFITAVNTAPWILTVGASTLDRKIKATVKLGNGEEFEGESAYRPKISNATFFTLFDAAKNAKDPSETPYCRRGSLTDPAIRGKIVLCSALGHVANVDKGQAVKDAGGVGMIIINPSQYGVTKSADAHVLPALVVSAADGTKILAYMNSTSSPVATIAFQGTIIGDKNAPMVAAFSSRGPSRASPGILKPDIIGPGANILAAWPTSVDDNKNTKSTFNIISGTSMSCPHLSGVAALLKCTHPDWSPAVIKSAMMTTADTLNLANSPILDERLLPADIYAIGAGHVNPSRANDPGLVYDTPFEDYVPYLCGLKYTDQQVGNLIQRRVNCSEVKSILEAQLNYPSFSIFGLGSTPQTYTRTVTNVGDATSSYKVEVASPEGVAIEVEPSELNFSELNQKLTYQVTFSKTTNSSNPEVIEGFLKWTSNRHSVRSPIAVVSA
Protein: hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) (Q583A8)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MFRTLPLRSSIRMVECPRDAMQGLPHFIPTEQKIRYLKALLKCGFYALDCGSFVSPRAVPQMRDSTEVIANCWKTMQEEKAAPKLSVVVASLAGFKQALETPGVSVIGYPIGCCERFQQRNAKKSIAMSLDEIRNIKEATDAFNAQRSSNPVAPNEDVNGRELLIYISMAFGNPYGESHSIDLVEKLVGELVASGARDISLADTTGVAQPPLIFDTFTQLRKKFPDVTFAGHFHSNAVEARGKIVAALDAGCTMIDSALCGMGGCPFAKDDGLVGNVATEVVVKALEERGVLPAALNKEQLKKCVLIKQEIFGVSVRDMLISQTLHDEKRFATLCQEHFKLYDVNDDGTLDYEGFRDSMIHVFAELGAPQPSEEKIRSSFAKVDIQNLGFITIDAYTMGARRLLVKRLASNTNTTTKNEERGEGVVEASSC
Protein: Guanine nucleotide-binding protein subunit gamma (D4AAI1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU004973}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU004973}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU004973}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- G protein subunit alpha transducin 2
- G protein subunit alpha transducin 1
- Guanine nucleotide-binding protein G
- Rhodopsin
- Phosphodiesterase
- Phosphodiesterase
- Guanine nucleotide-binding protein G
Sequence:
MPVINIEDLTEKDKLKMEVDQLKKEVTLERVMVSKCCEEVRDYIEERSREDPLVKGIPEDKNPFKELKGGCVIS
Protein: Sporulation sigma-E factor-processing peptidase (EC 3.4.23.-) (Membrane-associated aspartic protease) (Stage II sporulation protein GA) (P13801)
Organism: Bacillus subtilis (strain 168)
Function: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1744037, ECO:0000269|PubMed:18378688, ECO:0000269|PubMed:9663680}; Multi-pass membrane protein {ECO:0000269|PubMed:1744037, ECO:0000269|PubMed:18378688, ECO:0000269|PubMed:9663680}. Note=Localized to the sporulation septum.
Interaction partners:
- Stage II sporulation protein R
- Stage II sporulation protein E
- RNA polymerase sigma-E factor
- Anti-sigma F factor
- Anti-sigma F factor antagonist
- RNA polymerase sigma-G factor
- Stage III sporulation protein D
- Stage III sporulation protein AA
- RNA polymerase sigma-F factor
- Stage II sporulation protein M
Sequence:
MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGSSIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGIIGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQYEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIRNTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKCLIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS
Protein: Phosphodiesterase delta-like protein (Q18268)
Organism: Caenorhabditis elegans
Interaction partners:
- ADP-ribosylation factor-like protein 3
- ADP-ribosylation factor-like protein 2
- guanylate kinase
- adenylate cyclase
- GMP reductase
- Probable GMP synthase
- Adenine phosphoribosyltransferase
- Putative cytosolic 5'-nucleotidase 3
- Inosine triphosphate pyrophosphatase
- 5'-nucleotidase
Sequence:
MATTATRHQDSKLSEKAESILAGFKLNWMNLRDAETGKVLWQSTEDMADPKREHKAHVPKNLLKCRTVSREINFTSSVKIEKFRLEQRVYLKGTIIEEWYFDFGFVIPDSTNTWQNMIEAAPESQMFPPSVLSGNVVVETLFYDGDLLVSTSRVRLYYD
Protein: Translation initiation factor eIF3 subunit (Q4Q9M6)
Organism: Leishmania major
Interaction partners:
- Putative eukaryotic translation initiation factor 1A
- Translation initiation factor-like protein
- Putative eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 3 subunit E
- Putative translation factor sui1
- RRM domain-containing protein
- Putative elongation initiation factor 2 alpha subunit
- Eukaryotic translation initiation factor 3 subunit I
- Putative eukaryotic translation initiation factor 3 subunit 8
- Eukaryotic translation initiation factor 3 subunit 7-like protein
Sequence:
MDDYHDDDVHSNYGYEDDEYDDAADDWEAEAAEEEQRAVAEEAARQARLEKKLATRAPVKKEEEEEAVPEDVERAMADMRQVANDIASGSALLSGGDSEELIGNHKLASDADVERVGTMIADRLTSFSDSGHYDKLIVEVFQRLTNHLTSTHLLNEEADRVHRLREELKRAAKAKLKPVEKAPVTQSGLDLDNFEDRGGAAVADNEDETGW
Protein: Pre-mRNA-splicing factor SYF1 (Adapter protein ATH-55) (XPA-binding protein 2) (Q99PK0)
Organism: Rattus norvegicus (Rat)
Function: Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:12801913}. Note=Detected in the splicing complex carrying pre-mRNA. {ECO:0000269|PubMed:12801913}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase E
- Pre-mRNA-splicing factor ISY1 homolog
- Pre-mRNA-splicing factor SYF2
- Protein BUD31 homolog
- Pre-mRNA-processing factor 19
- RNA helicase aquarius
- Cell division cycle 5-like protein
- SNW domain-containing protein 1
- Pre-mRNA-splicing factor RBM22
- 116 kDa U5 small nuclear ribonucleoprotein component
Sequence:
MVVMARVPRPERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKMETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALKLLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIVINYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFISRYGGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMAVYDRATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTIREMLRIRRSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPPRAQSKIFFVRSDASREELAELAQQANPEEIQLGEDEDEDEMDLEPNEVRLEQQSVPAAVFGSLKED
Protein: Steroid 5-alpha reductase C-terminal domain-containing protein (Q57WY9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAQEGLKEVTDSPYFLKKWLAFIDYAANDLFGGPRPLKAAHVINLQKGGTLFFCLWLMKKSGNYSATAITYTALHGGYGLCWLLKELVFPDPKWQKHITFAGALTIFASVLGPYWYIVYNAIIRKAERSEGALCAATLVYLIGLVMMMCSDCQKYFVLKKKKGLITDGFFSRIRHPNYLGEMMIYGTFGFISNHVGSFGVLAWVWVGLFLPFMIQKEASMSRYSEWRAYKSRTGFLLPSVLPPKQKTTTVE
Protein: FMN-dependent NADPH-azoreductase (EC 1.7.-.-) (Azobenzene reductase) (O07529)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADPH, but not NADH, as an electron donor for its activity.
Interaction partners:
- FMN reductase [NAD
- FMN-dependent NADH:quinone oxidoreductase 2
- Uncharacterized transcriptional regulatory protein YhcZ
- Sensor histidine kinase YhcY
- Uncharacterized UDP-glucosyltransferase YdhE
- FMN reductase
Sequence:
MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNGEAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALLAVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELVEELSMFAKAGNPGV
Protein: Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55) (P20069)
Organism: Rattus norvegicus (Rat)
Function: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:2236012}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q10713}.
Interaction partners:
- Mitochondrial-processing peptidase subunit beta
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome b-c1 complex subunit 7
- NADH dehydrogenase flavoprotein 2, mitochondrial
Sequence:
MATAVWAAARLLRGSAALCARPKFGSPAHRRFSSGATYPNIPLSSPLPGVPKPIFATVDGQEKFETKVTTLDNGLRVASQNKFGQFCTLGILINSGSRYEAKYLSGIAHFLEKLAFSSTARFDSKDEILLTLEKHGGICDCQTSRDTTMYAVSADSKGLDTVVGLLADVVLHPRLTDEEIEMTRMAVQFELEDLNMRPDPEPLLTEMIHEAAFRENTVGLHRFCPVENIGKIDREVLHSYLKNYYTPDRMVLAGVGVEHEHLVECARKYLLGVQPAWGAPGAVWMLTAQWHSTRGGSSRWRETCQMSALRPPRFQSSHIYGGARELLLLEEDFIPFAVLNMMMGGGGSFSAGGPGKGMFSRLYLNVLNRHHWMYNATSYHHSYEDTGLLCIHASADPRQVREMVEIITKEFILMGRTVDLVELERAKTQLMSMLMMNLESRPVIFEDVGRQVLATHSRKLPHELCTLIRNVKPEDIKRVASKMLRGKPAVAALGDLTDLPTYEHIQAALSSRDGRLPRTYRLFR
Protein: Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (Q20077)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004450}. Rough endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00037860}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037860}.
Interaction partners:
- PIPK domain-containing protein
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphatidylinositol 4-kinase type 2
- Phosphatidylinositol 4-kinase type 2
- 1-phosphatidylinositol 4-kinase
- 1-phosphatidylinositol-3-phosphate 5-kinase
- Phosphatidylinositol-3-phosphatase SAC1
- 1-phosphatidylinositol-5-phosphate 4-kinase
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Synaptojanin
Sequence:
MKSESDVEYTIKQPDLTDVPTQSAKNLADGTIIVGENDTSDKEIEIEKEDTTKPTHDRQSWTMRLISSESFNAPMAVEYLNSIQDKPSLTFLGKRLFDLPEKDLDFYLPQLMYLYVTKVDAASVSHAYIEERNKKDAQFTVLCIWLLNCFTKNVPNKYENHALMLKSLLSRSNVPGTSQSADNMITLSLDRLEETNWTVGSSYGKSAGALARAAIQKESTLTAEHDSYEKSRCGPISTKLLTNQQNFIGRLVYIGVKLTEHHLLSSKQEKTIALQSELSMLNSMLPNSVWIPFDFENTMFNICVNESAVLNSKDKVPYVFFAEVIRSSPNYNSNIKTLSSVEPRIKKSQSESVLLKNKSYHDSTDPSIAVFAESWAEKKARIRGSSRYENHQKWDLIPVIVKTGDDLSQEAFAQQLLFTFKDLWHEEGVPLYLRPYKIVCIGSDAGLIEPVLDTLSLHQIKRHLTNVFRMNGNVTTPSLKHHFENVFGPVNSETYVNAQKNFIQSTAAYSLVSYYLQLKDRHNGNILLDMDGHLIHIDYGFLLSSSPRNLGFETAPFKLTTEIIDVMGGIDSDMFLYFKSLLLRGLMAARKHHRRIVSLAEIMSAGSKMQCFRAGAETVRALEARFHVSSTDEQLQQLVDTLVEGSRDSYTTRFYDSFQYYTNGIH
Protein: Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Q05502)
Organism: Gallus gallus (Chicken)
Function: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Forkhead box A2
- Uncharacterized protein.
- Proton-coupled zinc antiporter SLC30A8
Sequence:
MQYQAPGAAPAAALGVGVPLYAPTPLLQPAHPTPFYIEDILGRGPAAAPAPHSLPAPPPPTLPSPNSSFTSLVAPYRTPVYEPTPIHPAFSHHLAATYGTGAYAGPLYSFPRAVGDYTHALIRQDPLGKPLLWSPFIQRPLHKRKGGQVRFSNEQTIELEKKFETQKYLSPPERKRLAKLLQLSERQVKTWFQNRRAKWRRLKQENPQATKKEEAEGTGDHGDPRSEGSPSPAGGGEAEPQDSPSAASQEDPESDVSDDSDQEVDIEGDKGFYSATR
Protein: Protein bric-a-brac 1 (Q9W0K7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000269|PubMed:11973274}.
Interaction partners:
- TBP-associated factor 3
- Protein doublesex
Sequence:
MASAQAETNVGLASEQGPVAQRQRKGTGSGADSPKSNRSSPTQQEEKRIKSEDRTSPTGGAKDEDKESQGHAVAGGGGSSPVSSPQGRSSSVASPSSSSQQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLACDGRSMKAHKMVLSACSPYFQTLLAETPCQHPIVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGLADVTHMEAATAAAAAASSERMPSSPKESTSTSRTEHDREREAEELLAFMQPEKKLRTSDWDPAELRLSPLERQQGRNVRKRRWPSADTIFNPPAPPSPLSSLIAAERMELEQKERERQRDCSLMTPPPKPPMSSGSTVGATRRLETAIHALDMPSPAATPGPLSRSSRPHSQSPQQQQAQQQGQLPLPLPLHPHHHASPAPHPSQTAGSAHHPASPAGDSRFPLGPAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGGGVGGGGVGGGGAGGVGSGGGSSLADDLEIKPGIAEMIREEERAKMMENSHAWMGATGSTLAADSYQYQLQSMWQKCWNTNQNLMHHMRFRERGPLKSWRPETMAEAIFSVLKEGLSLSQAARKYDIPYPTFVLYANRVHNMLGPSIDGGPDLRPKGRGRPQRILLGIWPDEHIKGVIKTVVFRDTKDIKDESLAAHMPPYGRHSPAFPLQDLPLSYPGASGALAGAPSSMACPNGSGPQTGVGVAGEQHMSQETAAAVAAVAHNIRQQMQMAAVPPGLFNLPPHPGVGGGVGNVPGAAGGRASISPALSSGSGPRHAPSPCGPAGLLPNLPPSMAVALHHQQQQQAAHHHMQQLHLQQQQAHLHHHQQQQQQQQQQHHQGGHQVAHKSGFGASSSSSASSSSMGQHHAPKAKSSPLRSETPRLHSPLGDLGLDMASYKREFSPSRLFAEDLAELVGASVSSSSSSAAAATAPPERSAGAASAATGADAPSSSSSGGIKVEPITTTSE
Protein: 48 related 2, isoform E (A0A0B4LH77)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSRNQLPDSSSSPPISHLPFHNFDDDLINDLPSCIYAGQHQGGGATGGGGGSGGGGGSSGLRLSSNNLRHIQQHYMQHSGENLLDSSTNPMGVHNSGGGAPLMCNSPSASSSGGGCGNAGSATPGGAGGPNPGYGSVGAATASSYKMQRQAANVRERKRIQSSINSAFDELRVHVPTFPYEKRLSKIDTLRLAIAYISLLREVLQTDYDPLTYVEKCLRGEIKADRANWNTNLTARLSWINWENLGVHPGRRTLLTSLALSSEPMCGAHCGMP
Protein: Proteasome activator complex subunit 1 (Proteasome activator 28 subunit alpha) (Q2KJE7)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
MATLRVLPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPDLNEANLSNLKAPLDIPVPDPVKEKEKEERRKQQEKEDKDEKKKGEDEDKGPPCGPVSCNEKIVVLLQRVKPEIKDVIEKLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTALHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGMIY
Protein: Squalene synthase (EC 2.5.1.21) (A9XU48)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MGSLGALVKHPGDFYPLLKLKMASRHAERQIPSEPHWAFCFSMLHKVSRSFALVIQQLDTELKNAVCIFYLVLRALDTVEDDTSVATDIKVPILEEFYRHIYDRDWHFSCGTKNYKVLMDEFHHVSTAFLELEKGYQEAIEDITKRMGAGMAKFICKEVETVGDYDEYCHYVAGLVGLGLSQLFHACGTEDLAPDTLSNSMGLFLQKTNIIRDYLEDINEIPKSRMFWPRQIWGKYVNKLEDLKYEENSVKAVQCLNDMVTNALIHVDDCLKYMSALPDPAIFRFCAIPQVMAIGTLALCYNNIEVFRGVVKMRRGLTAKVIDRTNTMADVYGAFYDFSCMLKAKVDKNDPCAQKTSSRLDSILKTCRDSGVLNERKSYIIPNQTNYTPLLAVLLFILLAITLANRGPHEPN
Protein: Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase) (P9WNX5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate. Is essential for the growth and pathogenicity of M.tuberculosis, and for the generation of the bacterial cell wall.
Interaction partners:
- Aspartokinase
- 4-hydroxy-tetrahydrodipicolinate synthase
- Homoserine dehydrogenase
- Diaminopimelate epimerase
- 4-hydroxy-tetrahydrodipicolinate reductase
- Diaminopimelate decarboxylase
- 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
- Glutamate synthase large chain
- Putative succinyl-diaminopimelate desuccinylase DapE
- GMP synthase
Sequence:
MGLSIGIVGATGQVGQVMRTLLDERDFPASAVRFFASARSQGRKLAFRGQEIEVEDAETADPSGLDIALFSAGSAMSKVQAPRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFERDAHRRPKGIIANPNCTTMAAMPVLKVLHDEARLVRLVVSSYQAVSGSGLAGVAELAEQARAVIGGAEQLVYDGGALEFPPPNTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRFESRKILGIPDLLVSGTCVRVPVFTGHSLSINAEFAQPLSPERARELLDGATGVQLVDVPTPLAAAGVDESLVGRIRRDPGVPDGRGLALFVSGDNLRKGAALNTIQIAELLTADL
Protein: Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n) (P23527)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H4
- Histone H3.2
- Histone H2A type 1-D
- Histone H2A type 1-C
- Histone H3.1
- Histone H2A type 1-B/E
- Histone H3.3
- Histone H3-like centromeric protein A
- DNA
- Histone H2A type 2-B
Sequence:
MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Protein: Proteasome subunit alpha type (Q38B02)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Interaction partners:
- Proteasome subunit beta
- Proteasome regulatory non-ATPase subunit 8
- Proteasome regulatory ATPase subunit 5
- Proteasome subunit beta
- Probable 26S proteasome regulatory subunit rpn-6.2
- 26S proteasome regulatory non-ATPase subunit
- Proteasome subunit alpha type
- Proteasome regulatory non-ATP-ase subunit 5
- Proteasome regulatory non-ATP-ase subunit
- Proteasome subunit beta
Sequence:
MFKNQYDTDTTTWSPTGRLFQVEYANEAVNNGSAAVGVKGADYVVLTALKRNPVSGLSSYQEKAFKLDEHVGMAISGLVADGRALSRFLRTECMNYRYMHDSDAPLVMLADMVGAKHQRHIQFAGKRPFGVGLLIAGYDRQGPRLYQTVPSGDVFDFKATAMGLRSQAARTYLERHFRGFPACDLDELVMHALRALGAATSGGVELNIKNTTIAIVGKGTPFTILTEEEARKYLDGFKTRPEDIPAVADNEEDDDELHEQPPDVEE
Protein: General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH 89 kDa subunit) (Xeroderma pigmentosum group B-complementing protein) (P49135)
Organism: Mus musculus (Mouse)
Function: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular location: Nucleus.
Interaction partners:
- General transcription factor IIE subunit 1
- General transcription factor IIH subunit 3
- General transcription factor IIH subunit 2
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIH subunit 1
- General transcription factor IIH subunit 4
- General transcription factor IIH subunit 5
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIE subunit 2
- Cyclin-dependent kinase 7
Sequence:
MGKRDRVDRDKKKSKKRQYEEEEEDEDDIPGNESQEAVPSAAGKQVDESSTKVDEYGAKDYRQQMPLKGDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIIQFIKLCTVSYGKVKLVLKHNRYFVESSHPDVIQHLLQDPVIRECRLRNAEGEATELITETFTSKSAISKTAAEGSGGPSTSQGVDAQATSDIPKDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCICLEYPLLAEYDFRNDTLNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPARMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEELAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSGQASRRCGTMSSLSGADDTVYMEYHSSRSKASSKHVHPLFKRFRK
Protein: Helicase, putative (Q38D68)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRKDEYRNRQQGSFPLSNPYSRQGRGMSGNQHVSLTVRKDNYTDDSDICGGAYSSTVGDNRRLQHHRSDVDPYLHHDTQHTRDKRGWCDEQRSTKSRPCDYPQMVKSSEGAIRRSSSQQRWITQQQRCDDSVREVHRWDKETRPSDEWNQQRRHSEDALGSPPYPRSHGHPHGMNAGRQPPHSHLFPIPSYDRRAPRGAPPGYSGEEHRNSSEGHGQFADSSSHLMNAQRSIACEHDTQQQPQPEKDVRLHITRGYNSEFDVLQHLLHLQPKGETNTAHPRPLPNYRDAEGAGHHEPQSRCPKHQQEAWGESQRMEGRNWDTDQDRDAAMMDRDPRRGMDRDAAMVDRMIDGGAVGAGRMIDRRGGNRRGGRPSGSNVMPPSSLPPDKEALEKFKRLYALQEDQNETADHLRKQASSTTGVVGTLDVSQVLDLVAAHDVTIVVTDTGTGKSTLIPKAILDDDPGAKIVNTQPRRTPAIKLAERVSVFYGEKVGSRVGYWVRGEHAGEVGQTPIMYVTNYTLFLYLLHTTPDCIGMTHVIFDEFHERSVEVEVSLLLMKLVMKRNPGRIKLILCSATAEASKWAGFFDGLTVGEYSKANAMYPVHDYYLEDVSRLIGVACVAPDIESSGIMSSIQLHTIIFYMKKLLEFLATAAKPGDSILMFVPGRTVVEQLTLWIRDNLGEELDAIPWYRDIELSYVQEAIQRKSGTKKKVYVATDIAEVSITLPDVVFVIDSGTVKRPYITESNPNSVAFPPLELMWESAVNLKQRRGRAGRVQQGFFFTMVLKEQVPQLPPCDCRLSNAVIHEIVLHCLYLTSAPYILFSMCPEKPRNVSVQLSLNTLCDGGYIVPEEDHTSLIERIDNPEHLSIKKVWSELVSEAYESRSETKQGGLEGVDSRQLATKPPANLRYHVALRGLIVGRLPFAVNAGAVVFHGLLTGLTTLSIVAASCIACNSPFYVPYDVTDRVERLKVKNCVQETMLQFKGRLRNDVVSSVGAVLEYMQMQQEGLSEEGQNTWCEKRYLSRMRIVDILLLVQQAKDQLGALIPFEDIDDVGDLRRQYDTHAQMLSILCSAAFMQRGIFVLHDAETAQKKRFAGSGVFVNINCSRDMSVPTACPWTRNTVCVPYTLHTAYDRLVGSFSSQLSQEVYNVMLLVFSSTILFEEIVDEAAPVTFEVWQCGSRVFITCDCQTALQLLQLRRLMCARLCILHMLLQREASITDVETMSDLLIANGSNFGIPCNMEARPDLIPAMITSNVIRIIEGIEEAATKVRVGGNEGSAVPHCKPREPPPGFNPTRQSALVFSSNGCAPYHRPEPIPEPVGVMQHPRSYK
Protein: RNI-like superfamily protein (F4HV53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MERGLLELHLHAESFLFVERELFTSKTLVKLTLSAGYDFEAERVFLPALKSLYLLTDSGIDYDNHCRLLDGCPALEELFIRDADHDCPPCCGSVVKSASIKRLVVLVNLPNKRDSHDYAYFEAPSLVYLDYSSYVYETYQIVGLDSLVEARLSLKIWDYYDYNYDYEYDDESGDYYSDDDEGRSYCYSYVDDERKEPIFGDVTNLLAGVTNITTLHLSPDSLEAFYFCCKSMPVFNKLLNLFIESNKDKGWQGMPLLLKSCPILHTLVFKGLVHRVTNKCGDACACIPKKEKRENEKKNRKIVEKKLSCLWTCQVKVLEISKYDGSFQELKQMGHLLGKLGCLESVKVGVHADNNTEFLQANLLALPRLSSKCNNIQFS
Protein: Transcription factor ZEB2 (Zearalenone biosynthesis protein 2) (I1RFC6)
Organism: Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)
Function: Transcription factor that specifically controls transcription of the zearalenone biosynthesis cluster genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
Sequence:
MQSTESFHALPTRSDVEDPNERRKIQNRIAQKKHRQKMKRRIEELETKVNNQCQTSNWTSHAPTDSCQEQQFLDNTDFGLMLEDDLLYRELSASLDGAGLTAVAQMHDSPRPNQQQRLSVSGMPSSPTSTSNVAQRGLSIGDHSSASNHLSSLSLVPGSTEGSLPTRQHDNLCNQDLRDMVPEEKMSRILKVIQDAGYKDMDSFMTEYYVRDFDASSHVSAVQRQSRSRRLRGFLEQLRVGAESWSDYEAHDYQQEISKSAEAIYAKELDVFSTTTLGENASFQGLASLYRVLQSTVGSDIENHLRHEQSMMQRQVSEIVHRQVYTFNPAQC