wanglab/gogpt-training-data huggingface dataset:
Protein: Fimbrin-3 (AtFIM3) (Fimbrin3) (Q9FJ70)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cross-links actin filaments (F-actin). Stabilizes and prevents F-actin depolymerization mediated by profilin. May regulate actin cytoarchitecture, cell cycle, cell division, cell elongation and cytoplasmic tractus.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7G188}.
Interaction partners:
- F-actin-capping protein subunit beta
- Formin-like protein 12
- Actin cross-linking protein, putative
Sequence:
MSGFVGVIVSDPWLQSQLTQVELRSLNSKFVALKNQSGKVTLEDLPSVLVKVKSLSSSFKEKEIKEILGGLGSDYESDDDLDFESFLKVYLNLRDKAADKAGGGLKHSSSFLKAGTTTLHTINQSEKGSFVLHINRYLGDDPFLKQFLPLDPDSNDLYELVKDGVLLCKLINIAVPGTIDERAINTKRVLNPWERNENHTLCLNSAKAVGCSVVNIGTQDLAEGRPHLVLGLISQLIKIQLLADLSLKKMPQLVELVEDNEDIEEFLRLPPEKVLLKWMNFHLKKGGYKKTVGNFSSDLKDAQAYAYLLNVLAPEHCDPATLNAEDDLERANMVLEHAERMNCKRYLTAEEIVEGSSYLNLAFVAQIFHERNGLSTDGRFSFAEMMTEDLQTCRDERCYRLWINSLGIESYVNNVFEDVRNGWILLEVVDKVYPGSVNWKQASKPPIKMPFRKVENCNQVVKIGKEMRFSLVNVAGNDIVQGNKKLILGFLWQLMRTHMLQLLKSLRSRTRGKDMTDSEIISWANRKVRIMGRKSQIESFKDKSLSSGLFFLDLLWAVEPRVVNWNLVTKGESDDEKRLNATYIVSVARKLGCSVFLLPEDIVEVNQKMILILTASIMYWSLQQQSSSSESSSSSSDSSSTHSTTTTCTSTCTSTDASPAPSVTGEDEVSSLNGEVSSLTIEEDNEVSSLTIEEDNDADILSDITSISEEAANE
Protein: BTB/POZ and TAZ domain-containing protein 2 (BTB and TAZ domain protein 2) (Q94BN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a key role as a component of the TAC1-mediated telomerase activation pathway certainly by targeting a telomerase repressor to degradation. Seems to occupy an integral position in a complex signaling network that perceives, integrates, and responds to multiple, and sometimes competing, signals. Enhances responses to auxin in postgermination and vegetative development. Also negatively regulates ABA- and sugar-mediated inhibition of the germination. Essential for female and male gametophyte development.
Subcellular location: Nucleus {ECO:0000269|PubMed:19054356}. Cytoplasm {ECO:0000269|PubMed:19054356}.
Interaction partners:
- Transcription factor GTE11
- Transcription factor GTE9
- Cullin-3A
- Transcriptional regulator TAC1
- Granule-bound starch synthase 1, chloroplastic/amyloplastic
Sequence:
MEAVLVAMSVPATTEDDGFSLITDKLSYNLTPTSDVEIVTSDNRRIPAHSGVLASASPVLMNIMKKPMRRYRGCGSKRVIKILGVPCDAVSVFIKFLYSSSLTEDEMERYGIHLLALSHVYMVTQLKQRCSKGVVQRLTTENVVDVLQLARLCDAPDVCLRSMRLIHSQFKTVEQTEGWKFIQEHDPFLELDILQFIDDAESRKKRRRRHRKEQDLYMQLSEAMECIEHICTQGCTLVGPSNVVDNNKKSMTAEKSEPCKAFSTCYGLQLLIRHFAVCKRRNNDKGCLRCKRMLQLFRLHSLICDQPDSCRVPLCRQFRKRGEQDKKMGEDTKWKLLVTRVVSAKAMTSLCQSKKNKCEQAQGV
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (G1TCI4)
Organism: Oryctolagus cuniculus (Rabbit)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Erythropoietin receptor
- Signal transducer and activator of transcription
- Signal transducer and activator of transcription
- Interferon gamma receptor 2
- Growth hormone receptor
- Leptin receptor
- Signal transducer and activator of transcription
- Signal transducer and activator of transcription
- Prolactin receptor
- Signal transducer and activator of transcription
Sequence:
MGMACLTMTEMEETSTTPMHQNGDIPGNPNSVKQIDPVLQVYLYHSLGKAEGDYLIFPTGEYVAEEICVAASKACGITPVYHNMFALMSETERNWYPPNHVFHIDESTSHNVLYRIRFYFPHWYCNGSNRTYRHGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKEKDQTPLAIYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPDIIDVSIKQANQEGANESRVVTIHKQDGKNLEIELSSLKEALSFVSLIDGYYRLTADAHHYLCKEVAPPTVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPLSPTLQRHNNVNQMVFHKIRNEDLIFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMHFLEEKTLIHGNVCAKNILLIREEDRKTRNSPFIKLSDPGISITVLPKDFLQERIPWVPPECIENPKNLNLTTDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTFQICKGMEYLGTKRYVHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNHRPSFRDLALRVDQIRDNMTE
Protein: Ceramide very long chain fatty acid hydroxylase scs7 (Ceramide VLCFA hydroxylase scs7) (EC 1.14.18.-) (O13846)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- RNA-binding protein rsd1
- Delta
- Probable acyl-CoA desaturase
- C-4 methylsterol oxidase erg25
- Probable quinone oxidoreductase
- Sphingolipid C4-hydroxylase sur2
Sequence:
MASVTSEKCVILSDGTEYDVTNYLVANKDAADLLRRYHRQEVADILNATSKSKHSEAVVEILKSAKVPLKNKEFSDLVDQNIGVGYGNEFIVKPTDLDKDFEKNHFLDLKKPLLPQILFGNIKKDVYLDQVHRPRHYRGSGSAPLFGNFLEPLTKTPWYMIPLIWVPCVTYGFLYACTGIPFSVAITFFIIGLFTWTLVEYTMHRFLFHLDEYTPDHPIFLTMHFAFHGCHHFLPADKYRLVMPPALFLIFATPWYHFIQLVLPHYIGVAGFSGAILGYVFYDLTHYFLHHRRMPNAYLTDLKTWHLDHHYKDYKSAYGITSWFWDRVFGTEGPLFNEQGKISTKAK
Protein: Endoprotease Endo-Pro-Aspergillus niger (A2QR21)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Interaction partners:
Sequence:
MRSFSVVAAASLALSWASLAQAARPRLVPKPISRPASSKSAATTGEAYFEQLLDHHNPEKGTFSQRYWWSTEYWGGPGSPVVLFNPGEVSADGYEGYLTNDTLTGVYAQEIQGAVILIEHRYWGDSSPYEVLNAETLQYLTLDQSILDMTYFAETVKLQFDNSSRSNAQNAPWVMVGGSYSGALTAWTESIAPGTFWAYHATSAPVEAIYDFWQYFYPIQQGMAQNCSKDVSLVAEYVDKIGKNGTAKEQQELKELFGLGAVEHYDDFAAVLPNGPYLWQDNDFVTGYSSFFQFCDAVEGVEAGAAVTPGPEGVGLEKALANYANWFNSTILPNYCASYGYWTDEWSVACFDSYNASSPIFTDTSVGNPVDRQWEWFLCNEPFFWWQDGAPEGTSTIVPRLVSASYWQRQCPLYFPEVNGYTYGSAKGKNSATVNSWTGGWDMTRNTTRLIWTNGQYDPWRDSGVSSTFRPGGPLVSTANEPVQIIPGGFHCSDLYMEDYYANEGVRKVVDNEVKQIKEWVEEYYA
Protein: Cysteine protease inhibitor (G8IIS4)
Organism: Acanthamoeba castellanii (Amoeba)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSRPGGLGNARPADDEVNLLVAGVKADLENKAGRTFADLKPVSYATQVVAGINYFVKIAVAEGEYIHARIYRDLQRNVSVHSVQTGKSETDELEYF
Protein: Putative pyridoxal kinase BUD16 (EC 2.7.1.35) (Bud site selection protein 16) (P39988)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (By similarity). Important for bud site selection.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pyridoxamine 5'-phosphate oxidase
- Pyridoxal 5'-phosphate synthase subunit SNZ1
- Putative pyridoxal kinase BUD17
- Uncharacterized protein YGR017W
- Pyridoxal 5'-phosphate synthase subunit SNO1
- Probable pyridoxal 5'-phosphate synthase subunit SNO3
- Putative pyridoxal reductase
- Probable pyridoxal 5'-phosphate synthase subunit SNO2
- Probable pyridoxal 5'-phosphate synthase subunit SNZ3
- Probable pyridoxal 5'-phosphate synthase subunit SNZ2
Sequence:
MPRLLATQSHVVHGYVGNKAATFPLQCLGWDVDCCNSVQFSNHTGYGLDKVFGTITRETDLKELLSGLFDNFSQDYQALLSGYLPNKNSVRCMGTYYAKFKEANPEMIWLMDPVMGDEGQLYVSEDVIPEYRKLALSPKQLVDIITPNQFELEILYGGEIKTKEHLKKALKKLHQTIPVIIVTSCDCKMFDDKDFIYCVASMEGKTPIVYRVPFIDSYFTGVGDLFSALLLDRVYKILSNPTTTLKFEDQVNNVLNVIQKVLKITRSYASGKMKAKMGSALEMKEMELRLIESRDIYETINIHQTDYIYARL
Protein: Ethanolaminephosphotransferase 1 (hEPT1) (EC 2.7.8.1) (Selenoprotein I) (SelI) (Q9C0D9)
Organism: Homo sapiens (Human)
Function: Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine/PE from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway. PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes. The enzyme is critical for the synthesis of several PE species and could also catalyze the synthesis of ether-linked phospholipids like plasmanyl- and plasmenyl-PE which could explain it is required for proper myelination and neurodevelopment.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17132865, ECO:0000305|PubMed:28052917}; Multi-pass membrane protein {ECO:0000305|PubMed:28052917}.
Interaction partners:
- Ethanolamine-phosphate cytidylyltransferase
- Phosphatidylethanolamine N-methyltransferase
- Phosphatidylserine decarboxylase proenzyme, mitochondrial
- Phosphatidylserine synthase 2
- Phospholipid phosphatase 2
- Membrane-bound glycerophospholipid O-acyltransferase 2
- Phospholipid phosphatase 3
- Lysophospholipid acyltransferase 5
- Plasmanylethanolamine desaturase 1
- HCG2044781
Sequence:
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTGVSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVTISFVYIVTAVVGVEAWYEPFLFNFLYRDLFTAMIIGCALCVTLPMSLLNFFRSYKNNTLKLNSVYEAMVPLFSPCLLFILSTAWILWSPSDILELHPRVFYFMVGTAFANSTCQLIVCQMSSTRCPTLNWLLVPLFLVVLVVNLGVASYVESILLYTLTTAFTLAHIHYGVRVVKQLSSHFQIYPFSLRKPNSDULGMEEKNIGL
Protein: Gonadotropin subunit beta-2 (GTH-II-beta) (Gonadotropin beta-II chain) (GtH beta-2) (Q9DG80)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Function: Involved in gametogenesis and steroidogenesis.
Subcellular location: Secreted.
Interaction partners:
- Lutropin-choriogonadotropic hormone receptor
- Thyrotropin receptor
- Glycoprotein hormones alpha chain
- Nuclear transport factor 2
- Follicle-stimulating hormone receptor
Sequence:
MSVPASSFLLLCFLMNSFSPAQSYILPHCEPVNETVSVEKDGCPKCLVFQTAICSGHCLTKEPVYKSPFSNIYQHVCTYRDVRYETVRLPDCRPGVDPHVTYPVALSCECTLCTMDTSDCTIESLNPDFCMTQKEYILDY
Protein: Coiled-coil domain-containing protein 66 (A2RUB6)
Organism: Homo sapiens (Human)
Function: Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites. Plays a role in retina morphogenesis and/or homeostasis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:35849559, ECO:0000269|PubMed:36606424}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:35849559, ECO:0000269|PubMed:36606424}. Cell projection, cilium {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:36606424}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:36606424}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36606424}. Photoreceptor inner segment {ECO:0000269|PubMed:19777273}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:19777273}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:35849559}. Midbody {ECO:0000269|PubMed:35849559}. Note=Restricted to the centrosomes and the spindle microtubules during mitosis (PubMed:28235840). Enriched in the inner segment of the photoreceptor (PubMed:19777273). {ECO:0000269|PubMed:19777273, ECO:0000269|PubMed:28235840}.
Interaction partners:
- Coiled-coil domain-containing protein 14
- 5'-3' exoribonuclease 2
Sequence:
MNLGDGLKLETELLDGKTKLILSPYEHKSKISVKMGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNRGISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLLPLAENQEESFGSSF
Protein: Histone H2A.v3 (Q54HV7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H4
- Histone H2B.v3
- Histone H2A.z
- PWWP domain-containing protein
- Probable nucleosome assembly protein
Sequence:
MKRNNNLIIPLLKIKKLLKRKGCKRIQNSALVFFSKVLQYLIEELLEISMNVSILNKTKKYRIKPKDISWSIQSDPEFNLLFRNIIIPSSGRISNKLNRIIQRSFKFKSFKFDDYEKSDYSSKTF
Protein: Growth differential factor 9 (Q6KCM2)
Organism: Sus scrofa (Pig)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
AVEHLLKSVLLYTWNNSISFPSPVKCECSLVVKEPELSNKTLPKAPYSFTLNSPFTFQKKHKWIEIDVTAILQPLVVSNKREIHMSIDFTCVKDQLQHLSAQESPCNMTLLAAPSLLLYLNDTSTQAYHRWYSLPWKRRPSQGPDQKRGLSEGVPSSRHRRAQDTVSSELKKPLVPASFNLSEYFKQFLFPQNECELHDFRLSFSQLKWDNWIVAPHKYNPRYCKGDCPRAVGHRYGSPVHTMV
Protein: Uncharacterized protein C17A2.08c (O13758)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-splicing factor cwf4
- Protein NRDE2 homolog
- G-patch domain-containing protein C1486.03
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing factor brr2
- Uncharacterized protein C140.04
- Pre-mRNA-splicing factor cwf3
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43
- Pre-mRNA-splicing factor cwf12
Sequence:
MRRYLKKAKPKIVQTSDNEEEKHEENLNVSQSNKNANRRKTKAKEKNSGKFRVKYENEEGDDDGEDSQIPLIPKVKKQSSFHSVDDLISRRMDALSHESGYSNAYVDELKRKSRQTPSEFTKKEEDSSTKESELQTRSSPPLPVNTSLEWNMLNQGIPEEAMIKELKDREGRKRNIAMMTDNYISLETGDQLMLAQNHKEEKLLQTEDEIQDEGYSGFENYVEESEKLQEIYHHSSESLRTRSIQMAVDQKNMEMELDDEDIAEPIQSWEHTQIKKGAFGESPAFTNGLSVKLPNILTMDEQIQRLKEAIASEKLQQEERSQIIKSLMEEELEINEQEEKIKHSFIDLDKTLLNNLTKSKS
Protein: Neurogenic differentiation factor 1 (NeuroD1) (Q91616)
Organism: Xenopus laevis (African clawed frog)
Function: Acts as a transcriptional activator. Plays a role as a differentiation factor during neurogenesis. Required for the conversion of cells within the neural plate and ventral ectoderm into differentiated neurons. Promotes the differentiation of late-born retinal amacrine cells, but not early-born retinal ganglion cells. Its function is inhibited at early stages of retinal cells differentiation.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MTKSYGENGLILAETPGCRGWVDECLSSQDENDLEKKEGELMKEDDEDSLNHHNGEENEEEDEGDEEEEDDEDDDEDDDQKPKRRGPKKKKMTKARVERFKVRRMKANARERNRMHGLNDALDSLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQSQDIQSHMQTASSSFPLQGYPYQSPGLPSPPYGTMDSSHVFHVKPHSYGAALEPFFDSSTVTECTSPSFDGPLSPPLSVNGNFTFKHEHSEYDKNYTFTMHYPAATISQGHGPLFSTGGPRCEIPIDTIMSYDGHSHHERVMSAQLNAIFHD
Protein: Tr-type G domain-containing protein (O62108)
Organism: Caenorhabditis elegans
Interaction partners:
- Ubiquitin-like domain-containing protein
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 2 subunit 1
- Probable selenide, water dikinase
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS6
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit I
- RRM domain-containing protein
Sequence:
MTSPPSTSSSVGPLNLGILGHVDSGKTTLTRRIAELGSTSAFDAHATSTTTDGIRRNTLDLGFSTMTSLSGRRLALIDCPGHSGLIRAVLAASTVFDMAIVIIDVVAGIQPQTAEHLLLASKFCPNRVIIVLNKCDLAEKSKISESAKKVRKGLKSMGVDENSPIVEMSLADGYFKEEMLQNLKLAIESRIFEPKRDEEGEFLIAIDHCFAIKGQGTVLTGTVIRGVLRLNTEIEFPALNEKRRVKTLETWKQRVGQVAAGARAAFLVAPSFDEHRFSRCICGPLGTLKSTKFVLATVEPIQFFRKSINSKSKIHVAVAFETVMAECQFLKEKENGEFEMLPSLLAPCQVLFSFEKSIFLPENYSNPFMAARLEQQPGSGCRFAFSGIFSQILPENGKNLPPRFTRKCRKGHVERVEKDGFSAICTGMFKAETNFDVFRGFQICTSSGPRGKIEGAFGKSGKFRVTFAEKIDGILTEKEEISLFLKKYHNENRLVSYVPD
Protein: Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein) (Q5FW52)
Organism: Mus musculus (Mouse)
Function: Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD.
Subcellular location: Nucleus {ECO:0000269|PubMed:21498514, ECO:0000269|PubMed:22343712, ECO:0000269|PubMed:26436652, ECO:0000269|PubMed:33802236}. Nucleus envelope {ECO:0000269|PubMed:21498514}. Nucleus, PML body {ECO:0000269|PubMed:21498514}. Cytoplasm, cytosol {ECO:0000269|PubMed:21498514, ECO:0000269|PubMed:22343712, ECO:0000269|PubMed:26436652}. Cell membrane, sarcolemma {ECO:0000269|PubMed:26359501}; Peripheral membrane protein {ECO:0000269|PubMed:26359501}; Cytoplasmic side {ECO:0000269|PubMed:26359501}.
Interaction partners:
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinase inhibitor 1C
- Cyclin-dependent kinase inhibitor 1
Sequence:
MTSCILAGSLETTPKVSPGDPEAKPLIFTFVPTLRRLPTHIQLADTSKFLVKIPEEPTDKSPETVNRFEYSDHMTFSSESKQERVQRILDYPSEVSGRNSQQKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGGPGNIATRPKSLAISSSLASDVVRPKVRGADLKTSSHPEIPHGIAPQQKHGLLISPTTSEQLAHKPPAFSFVSPTNQKTPPVPANVSGATVLREFHTRRLDVTGASEEETTTYFHSTAHDSPLSAWKGASTLVVSPSAQLSGSSLCGSNVTDHTRGLASEAQKKMSTSNVLNPKEDVRTCPAPASGASLTSPSASYIPVRIVMHSLSPSPKPLTSSSHGSLSTVCSQMSSSGSLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLSPASCPTFSLNSLASSTLALDQKVKQTPPTSKKSLSSGSLTTGSTEQEHQASAASYQPCHLPFFSKTTPLSQAQPLSPLALASNSCASMDIEKIPGSTLRSNTTSPQPQTDTFSLADVPSVTPVLSPLSSSKGRKDGDSRTPEKNRNICIQPSTLASTPPVDESLALSSSGKGFHPSPALSDLIDRSKRACSQQHPGQRPSPSALPTPPVSRAASASHPHLGCSILPLQSSLTQTLQPSPSALRPSCGSATCPSRTQMPENTASNHSSRVSTPSLPVSLTRTKELFSPCALSMSAGPENKKPKQYKTMSSYKAFAAIPTNTLLLEQKALDEPARTESNSKASVLDLPVEFCFPAQLRQQTEELCATIDKVLQDSLSMHSSDSPSRPPQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTASESQLTKPGVIRPVPVKSKLLLRKDEEVYEPNPFSKYLEDNSGLFSEQDMAIPHKPVSLHPLYQSKLYPPAKSLLHPQTLSHADCLTPGSFSHLSSFSVRDEQEKSPTLLSQDTYNKLGHPMVTIPEHDTLDSKE
Protein: Succinate dehydrogenase assembly factor 1, mitochondrial (SDH assembly factor 1) (SDHAF1) (Q9US02)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit sdh2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q3E785}.
Interaction partners:
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
Sequence:
MALSGLQRQVIHFYRRCLHAAKAKEQPYNERWMAFVHQEFRKNQTISKRDFFYIEHLLRVGQRQYEAYSRPEVKDIHFS
Protein: Ankyrin 2 (A0A5F9ZI69)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Protein: Protein C-ets-2 (P15037)
Organism: Mus musculus (Mouse)
Function: Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Protein C-ets-1
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- DNA-binding protein inhibitor ID-1
- Cellular tumor antigen p53
- Serum response factor
- Cyclin-dependent kinase 10
- Histone lysine acetyltransferase CREBBP
- Trans-acting T-cell-specific transcription factor GATA-3
- Protein c-Fos
Sequence:
MNDFGIKNMDQVAPVANSFRGTLKRQPAFDTFDGSLFAVLPSLSEDQTLQEVPTGLDSVSHDSASCELPLLTPCSKAVMSQALKATFSGFQKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLHQFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEENSHLNAVPHWINSNTLGFSMEQAPYGMQAPNYPKDNLLDSMCPPSATPAALGSELQMLPKSRLNTVNVNYCSISQDFPSSNVNLLNNNSGKPKDHDSPENGGDSFESSDSLLRSWNSQSSLLDVQRVPSFESFEEDCSQSLCLSKLTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED
Protein: Uncharacterized protein C4orf17 (Q53FE4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNLNPPTSALQIEGKGSHIMARNVSCFLVRHTPHPRRVCHIKGLNNIPICTVNDDENAFGTLWGVGQSNYLEKNRIPFANCSYPSSTAVQESPVRGMSPAPNGAKVPPRPHSEPSRKIKECFKTSSENPLVIKKEEIKAKRPPSPPKACSTPGSCSSGMTSTKNDVKANTICIPNYLDQEIKILAKLCSILHTDSLAEVLQWLLHATSKEKEWVSALIHSELAEINLLTHHRRNTSMEPAAETGKPPTVKSPPTVKLPPNFTAKSKVLTRDTEGDQPTRVSSQGSEENKEVPKEAEHKPPLLIRRNNMKIPVAEYFSKPNSPPRPNTQESGSAKPVSARSIQEYNLCPQRACYPSTHRR