Protein: Bromodomain adjacent to zinc finger domain protein 2B (A2AUY4)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (By similarity). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (By similarity). Chromatin reader protein, involved in positively modulating the rate of age-related behavioral deterioration. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063}.
Interaction partners:
- WD repeat, SAM and U-box domain-containing protein 1
- DNA polymerase epsilon subunit 3
Sequence:
MESGELLPSSPASSTTPTSSSAPSVASAVSKSSLSTGAASLSSTASPCVLEAGKSKIKVSPDSVSGAEWWRTTDGHSRAGTPFFPPLLGIPPLFAPPAQNHDSSFHSRTSGKSSRNGPEKGINGSVNGTSAASVLGVNASVVATPASSSMGQNQSTSSGGGTLKCHQEQNKSQPVDARADRIKDKKPRKKAMESSSNSDSDSGTSSDTSSEGISSSDSDDLEEEEEEDQSVEESEDDDSDSETEAQHKSNNQVLLHGISDPKTDGQKATEKAQERRTHQPLPPVSESQTHPPFQSQQKQPQVLSQQLPFIFQSSQAKEESVTKHTSVIQSTGLVSNVKPLSLVNQAKKETYRKLVVPSPDVLKAGNKNTSEESSSLTSELRSKREQYKQTFPSQGKKQEMGKSLKKVIAALSNTKATSSSPAHPKLPLDNNHPNPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENVSSSTPFSSPVNLSTSGRRAPGSQTPALPSASPILHSSGKEKRVSNDATPLKAHHHPHPAAAAAALVEQFRGTDSDVPSSKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSQSDSEGSEDDEEKDQEESDSDTEGEKPAVNLTQTSSSAKSPPSSLTAHSAPHLHIGSPPGSAPAALCSESQPPAFLGTSSSTLTSTPHSGTSKRRRVADDQELRIPLDYGWQRETRVRNFGGRLPGEVAYYAPCGKKLRQCPDMVKGMQWCLLKEEDVIPRIRAMDGRRGRPPNPDRPRAREESRMKRRKGRPPNVGSAEFLDNTDAKLLRKLQAQEIARQAAQIKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQMKIIKQQEKIKRIQQIRMEKELRAQQILEAKKKKKEEAANAKLLEAEKRTKEKELRRQQAVLLKHQERERRRQHVMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPKEDMCLADQKPLPEWPRIPGLVLSGTTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEVLQIFMEAHCGQTELTESLKTKAFQAHTPAQKASILAFLVNELACSKSVVSEIDKNIEYMSNLRRDKWMVEGKLRKLRIIHAKKTGKRDASGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQADEDEEDEEDKDDKKGKKTDICEDEDEGDQTASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSMMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEKEKLKKAESLQIKEEVFETSAETLNCSIRDHCEQKDDPKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESDVMTPPKVNVSTNGGPLSHQNSGKHPLGSVPSATTAQSPVGKTDASLFSSGSGSCGKFYSPLPNDQLLKTLTEKNRQWFSLLPKTPCDDTSLTHADLSTTLVTPQSQPPSKSPSPAPAALLGPSSVQSPPGLNPFALSPLQVKGGVSMMGLQFCGWPAGVLASNVPFTSPLPALGSGLGLPEGNGSSSFLTSSVASSKSDSPVPPAERPSSAQPVAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKTLLKVLHLRGIREKALQKQIQKHLDYITQACVRNKDVAIIELNENEDNQVTRDLVENWSVEEQAMELDLSILQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSLTKLFKEHDGELTGDEENSAHALARKSDNPLDIAVTRLADLERNIERRYLKSPLSTTIQIKLDNVGTVTVPAPAPSISGDGDGIEEDIAPGLRVWRRALAEARSAAQVALCIQQLQRSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACISKASGQSIKIKKIHVKGKKTNDSKKTKKGNVAGDTEDEDSASTSSSLKRGSKELKKRKMEETTSLNLSKAESTTSIKKPKKDESRDLALCSMILTEMETHEDSWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLNNGQYPNFETFALDVRLVFDNCETFNEDDSDIGRAGHSMRKYFEKKWTDTFKVS