wanglab/gogpt-training-data huggingface dataset:
Protein: Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) (P18911)
Organism: Mus musculus (Mouse)
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:15327771}. Cytoplasm {ECO:0000250|UniProtKB:P13631}.
Interaction partners:
- Retinoic acid receptor RXR-gamma
- Retinoic acid receptor RXR-alpha
- Arginine--tRNA ligase, cytoplasmic
- Nuclear receptor corepressor 1
- Cellular retinoic acid-binding protein 2
- Retinoic acid receptor alpha
- Retinoic acid receptor beta
- Retinoic acid receptor RXR-beta
- Nuclear receptor corepressor 2
- Cytochrome P450 26A1
Sequence:
MATNKERLFAPGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGGQGKRGQSPQPDQGP
Protein: Stationary phase protein 5 (P42933)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for survival at high temperature during stationary phase.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase RPN11
- Proteasome activator BLM10
- Ubiquitin-binding protein CUE5
Sequence:
MAVGGNNWSMWLRMSRVHLRQITKSLDRTLISLSHGNFSHQYNRNIFVTWWKSLFEASTAFRRASGLTVSPLTRRGIARFDHFRPVPNVSKFASFPRVPKGAPRGLFTNWNMTTSKRLLGQRAYSTSSIKFTQEAVNNMTISLRCFFNSLGGLNQCSHSNSCKAYQNASNVTSKQDHVQPVALKKLSQKDINFIRNLELFKIMKTQNEVVDETSAYYMEKPGSYIEFTISEFNVNGTFSAPLSFLDPSLLADLDEMIRNYKYELKSIYSSVDMILQNYGSLPITFHRNKIRIHFPNSTVVETEKLIAGLNIATGVIYADTSPDISLEGTNLNALVNVDNSGSVWSFVKEPSFPSRSAFSPILSDASYDTYELV
Protein: ACB domain-containing protein (Q09603)
Organism: Caenorhabditis elegans
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
- 3-ketoacyl-CoA thiolase
- Probable 3-ketoacyl-CoA thiolase
- Acetyl-CoA acetyltransferase homolog, mitochondrial
- Acetyl-CoA C-acetyltransferase
- Hydroxysteroid dehydrogenase-like protein 2
- Fatty Acid CoA Synthetase family
- Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Probable glutaryl-CoA dehydrogenase, mitochondrial
- Acyl-coenzyme A oxidase acox-3
- Acyl-coenzyme A oxidase acox-1.1
Sequence:
MLRNLTLAARSVLYNPQVSVRSFSAQADFEKAQKNLKTLKEEPDNDVKLQLYGLFKQATAGDVQGKRPGMMDFVGRAKYDAWNTLKGQTQDEARANYAKLVGGLISEEASAAPEPTGPSIEGLENVDGLSVTREGKVFKIALNRPKKFNALTLEMYQGIQKALEVSNNDKSTSITVITANGSYYCAGNDLTNFKAAAGGTKEQIADMANTAKVIMKDYVNAYINHEKPLIALINGPAVGIAVTVLGMFDYVIATDKASFHTPFAPLGQSPEGVSSYTFPLIMGSLRASEMLLVCKKISAQTAKDYGLVNEVVPDAEFQSHAQKTVEAFSQLPPETLRINKKLLRSLHKEKLLEVNNIEADQICERWQSKECHQAIAAFMTKGAKK
Protein: Proton-coupled zinc antiporter SLC30A9, mitochondrial (Human embryonic lung protein) (HuEL) (Solute carrier family 30 member 9) (Zinc transporter 9) (ZnT-9) (Q6PML9)
Organism: Homo sapiens (Human)
Function: Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health. In nucleus, functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity).
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:34397090, ECO:0000269|PubMed:35614220}; Multi-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:10409434}. Endoplasmic reticulum {ECO:0000269|PubMed:28334855}. Note=Partial co-localization with endoplasmic reticulum (PubMed:28334855). Linked to mitochondrial ribosomes (PubMed:35614220). {ECO:0000269|PubMed:10409434, ECO:0000269|PubMed:28334855, ECO:0000269|PubMed:35614220}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A5
- Zinc transporter 6
- Zinc transporter 7
- Probable proton-coupled zinc antiporter SLC30A4
- Proton-coupled zinc antiporter SLC30A1
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Zinc transporter ZIP11
- Proton-coupled zinc antiporter SLC30A2
- Zinc transporter ZIP9
- Zinc transporter SLC39A7
Sequence:
MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNMVPCSHPYIGTLSQVKLYSTNVQKEGQGSQTLRVEKVPSFETAEGIGTELKAPLKQEPLQVRVKAVLKKREYGSKYTQNNFITGVRAINEFCLKSSDLEQLRKIRRRSPHEDTESFTVYLRSDVEAKSLEVWGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAVNELRRNARAKGMSFYKYVMESRDPSTNVILLEDTAAVLGVIIAATCMGLTSITGNPLYDSLGSLGVGTLLGMVSAFLIYTNTEALLGRSIQPEQVQRLTELLENDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPEELETFMLKHGENIIDTLGAEVDRLEKELKKRNPEVRHVDLEIL
Protein: Replicative DNA helicase DnaC (EC 5.6.2.3) (DNA 5'-3' helicase DnaC) (P37469)
Organism: Bacillus subtilis (strain 168)
Subcellular location: Cytoplasm, nucleoid {ECO:0000269|PubMed:21170359}. Note=Localizes in tight foci to the chromosomal replication center at mid-cell; positioning does not rely on the C-terminus of SSB (ssbA) (PubMed:21170359). {ECO:0000269|PubMed:21170359}.
Interaction partners:
- Replicative helicase loader DnaI
- DNA primase
- Replicative helicase loading/DNA remodeling protein DnaB
- Chromosomal replication initiator protein DnaA
- Beta sliding clamp
- Uncharacterized protein YqaM
- DNA polymerase III subunit tau
- DNA polymerase III PolC-type
- Single-stranded DNA-binding protein A
- Replicative helicase loading/DNA remodeling protein DnaD
Sequence:
MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFYRMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANIEYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQNIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKLTMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDNRQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGVPPGA
Protein: Acetyl-CoA carboxylase (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)] (Q54J08)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- [acyl-carrier-protein] S-malonyltransferase
- Probable acetyl-CoA acetyltransferase
- malate synthase
- Malonyl-CoA decarboxylase C-terminal domain-containing protein
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Acetyl-coenzyme A synthetase
- medium-chain acyl-CoA ligase
- medium-chain acyl-CoA ligase
- Acyl-CoA synthetase family member 3
- Probable ATP-citrate synthase
Sequence:
MIEINEYIKKLGGDKNIEKILIANNGIAAVKAIRSVRKWAYTNFGNERAIKFVVMATPEDMKANAEYIRMADQILQVPGGSNNNNYANVDIIVDFAERAGVQAVWAGWGHASENPRLPDLLSKTETGIVFIGPPAKAMADLGDKIASTIVAQSARVACVPWSGSGLKVDYSECNGVPSEIYGRACINSVEEARECAQRVGFPAMIKASEGGGGKGIRKVTSMEDLESSFRQVQNEVPGSPIFFMKLVSNARHLEVQIVADRHGEAISLNGRDCSVQRRHQKIIEEGPAIAPTPQVWEEMERAAVRLVKEVGYVGAGTVEYLFAEGEYYFLELNPRLQVEHPVTEQITGVNLPATQLQIAMGIPLHRIPDIRKLYGRTGDDLYGDSMIDLHDFTKRNPPAGHCIAVRITGENPDEGFKPTSGQIHELTFRSTPNIWGYFSVGAKGGLHEYADSQFGHIFANGATREEARKTIILGLKEISIRGDIRTPVEYIIHLLESKDFKENHIHTGWLDQLISEKIQTKKPETMIVVLCGAIYKASTIFSTKIQEFSNQLSNGQLPSLELLNNSLPIELIYNNVKYQFEVSRTGINNYSVCLKNDKSAVSIDSSVIMLSDSGLLILLNGSTHVCYGREDVIGLSLMIDSKTCVFSQEYDPSILRTSSPGKLVRYLVDDGSLVVKGTPFAEIEVMKMYMPLLVPEKGIIKFVLTEGSVMAPGAIIANLELSDQSSIQKSTVFTGSLTKMSPPTLIGNKPHQLLNYTLGKISNVLCGYESNDLNQLLNDTIKQLSNQKLPLFEFKEQLSIVQSRIPQSLFKLINDELNKFEFNNDDDDEDDSELFNSKNLQLSISLYLNKLLLENEQLSIAIQLLIKPIILLAEKYNDGVSFAAINIFKNYLEEFIQIETNLQNKNIQTVLKSIRPTYKDNISKVVDIAQSLHPQSKKYKFILLLLNKIQEQGLVCDFVEQFKKLSSLGGNCMEISLKAKHIMVHSQLPSNKQRSNDLINSLKSILNVNNEQQQQVDEKVQDNKDEKISKLSKQTNEISDILIPMFFNESNNDDDIRKLAMEVYVRHSYRSYYVEDTKVTLSNDEGSSGFSFIEWHFYINLPQQSNLGGSNSGSPTYGSPLIRSISSSGGSSGGSGFQISPRPSMSIFNGLSMLRTDSTDSLTAMEDQTKLRYGMMVFFENEKKFEEKLPLILTRYNEENNKKSQLSLSPNESTDILSVIISIYPESISQENQAISSFQSILKGYIKELSIARIRRITFICCGGDEGKPLKYFTFRERHMYMEDPIFRHIEPAMAYHLEVRKLSNFDITHVPTTSQRIHLYYAQEKGKKETDPDADRSFFVRSVIRYSDLYGHSNEIKVDILLSQIETLLSESIESLEIAMSNKKYEKAQNHSIFLNVMPEVMFDEKMIGYVVQEIGDRLGKRLWKLRVGRVEVRGRIRKGDGLIPVRFFVQNPTGYAFQVQCYYEQQNSIGQMVFAVVPGSSKGSWEGLPVDTPYPIMDAVQRNRFKAQRLDTTYCYDYPDLFREAMQNIWMEFMESNKTNPVKVYPSSRGVLESVELILPSTINTDFPPSIPLDQLPEESKPKLEETYRPIGYNDIGMVAWRMTFYTPEYPLGRQAIVIANDITHQIGSFGPQEDMLFKLASELARKEKIPRIYLSSNSGARIGLADEIKSKFKVTWNVPSDPTKGIKNLYLTNNDYQALKDSVIAYQDTTDKDKWIIHDIIGQKNGIGVENLSWSGLIAGETSQAYNEIFTITLVSGRSVGIGAYLVRLGQRTIQNDAPIILTGASALNKVLGKEVYESNQQLGGSQIMYPNGVSHIIVNDELRGITNVLQWLSFVPKSGGEMVPIISPIDSPHRDIEFDPSNSINGKCDTRHLIAGLQSELDPNYWISGMFDKDSFMETLAGWANTVITGRARLGGIPVGIIAVETKSVEKIIPADPANPLSYEQVNTQAGQVWYPDSSFKTAQAIADFNNGEELPLMILANWRGFSGGMRDMFDEILKFGSMIVDNLRNYKQPVMVYIPPFAELRGGAWVVLDSTINLDMMEMYCSEEGRGGVLEPNGIAEIKYRDPELIKTMHRLDPKLIEWDKSIPIGVSVNGLDQSQKTIKSQIQQREKELLGIYQQIAIKFADLHDTPGRMKAKGVIKQMVPWKSARSFFYDRIKRRLFEEDKLKLIDKSHPGLNRQSKLNLLETWIKQILGNNQSVDYHQNDKLISSTIESNSHIINDKIIDLSKQYAINQILNFVQSDSESIVDGFQNLLPFISTQQKEFLFESLKKDLNK
Protein: Xylitol-binding protein (A0QYB3)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Part of an ABC transporter complex likely involved in xylitol import. Binds xylitol.
Subcellular location: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
- Ribose transport ATP-binding protein RbsA
- Ribose transport system permease protein RbsC
- Ribose transport system permease protein RbsC
- Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components
- Ribose transport ATP-binding protein RbsA
- Ribose transport ATP-binding protein RbsA
- D-threitol-binding protein
- Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components
- Ribose transport system permease protein RbsC
- Ribose transport system permease protein RbsC
Sequence:
MNITSKIGAIAAAGAVGLGLTACGAGDTAANSDTKRIGVTVYDMSSFITEGKEGMDTYAKANNIELVWNSANNDVSTQASQVDSLINQGVDAIIVVPVQADSLGPQVASAKSKGIPLLAVNAALETPDLAGNVQPDDVAAGAQEMQMMADRLGGKGNIVILQGPLGGSGEINRGKGIDQVLAKYPDIKVLAKDTANWKRDEAVNKMKNWISSFGPQIDGVVAQNDDMGLGALQALKEAGRTGVPIVGIDGIEDGLNAVKSGDFIGTSLQNGTVELSAGLAVADALVKGEDVKTDPVYVMPAITKDNVDVAIEHVVTERQKFLDGLVELTQQNLKTGDIAYEGIPGQTQP
Protein: UPAR/Ly6 domain-containing protein crim (Protein crimpled) (Q9VTM6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.
Interaction partners:
- UPAR/Ly6 domain-containing protein crok
- Kune-kune
- UPAR/Ly6 domain-containing protein bou
- UPAR/Ly6 domain-containing protein cold
Sequence:
MHYHTNLIAALLLAALIHEGSAIWCYRCTSATPGCAEKFNWRGIGFLGEHCPEPDDICVKVTERRGARETITRDCLSALSFRKDIPADKYEGCRPAAHDEKLANYVNHTIKEHDVRRDYYTDTTFCFCFLDHRCNGASGLQTSAVIGLLTLIPALLLR
Protein: Krt78 protein (Q0VDN0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSLSPCRAQRGFSAHSACSAFSGARGRTGFSSRSLSSSRRCRGSSCGRAWGAETRQGIRFGQGKGGPGFSQCPPGGIQAVTVDQSLLTPLKIEVDPQFQVVKTQETREIRSLNNQFASFIDKVRFLEQQNKVLETKWELLQQLQGNRSPQGLECIFETCLARLRQQLEELQRERRALDSELKTYQDQEDEYKSKYDQEAYKHASVQNDFVVLKKDVDEVFQSKMDLEGNLESLKEHVCFLTRLYEEELGQLKTQADDMSVVLSMDNNRCLDFSDIIAEVRARYEEITRTSKAEAEAVFQTKYQELQESAQLQGNSMKEAQVQISQLRQAIHRLQSQIGSLRKQNDSLQSAIADAEQQGEMAVRDAQAKLDELEAALRTAKQDMAQMLRDYQELMGTKLSLDVEIAMYRRLLESEECRISTEHTSQVTVSITEGSIVPGRTCGGQVVVPGRIGTGQVVMPGRECGGHVVMPGRGSGGQVTIPGRGSGGQVTVPRGECGGQVTMPGRGSGGQVTV
Protein: Sequestosome-1 (F1Q5Z8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, myofibril, sarcomere {ECO:0000256|ARBA:ARBA00004204}. Cytoplasmic vesicle, autophagosome {ECO:0000256|ARBA:ARBA00004419}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- TNF receptor-associated factor 6
- Serine/threonine-protein kinase TBK1
- GABA
- Map1lc3b protein
- NBR1 autophagy cargo receptor a
- Gamma-aminobutyric acid receptor-associated protein-like 2
- GABA
- Microtubule-associated protein 1 light chain 3 alpha
- Autophagy protein 5
- Receptor
Sequence:
MSMTVKAYLIGKEDCNKEIRRFAVDQDVSTSFEYLQRKVLDVFVGLRTAPFQMYYKDEDGDMIAFSSDDELMMGLALVKDDTFRLFIKQRKEHKRDSSPHGIPGFPFTTPHFSPPGPCHMGPSPMGPPGPPHMGGPPHHPHPMVHPGVTCDGCDGPVAGTRYKCTVCPDYDLCPTCQSKGLHKEHALLPIFHPMANVFEWLPRGKFWRKMRHCMWANAQAQAQNQPQPGPSGAQQNQDAPENPNENGATASSQANVEYLKNIGEEVAAMLSPLGIDVDIDVEHEGKRTKVTPTPPASSGPSSARSDSGSVGLLSRGSGPGSQATEESVSEGTKKDQCSDEEWTHLSAKEVDPSTGELQSLRLEQDGADLPAPLNTASGTSTRDGPTGLREAALYPHLPQDADPRLVESLSQMLSMGFTDEGGWLTRLLHTKNYDIGGALDTIQYSKTPGQQK
Protein: Large ribosomal subunit protein uL23cz/uL23cy (50S ribosomal protein L23, chloroplastic) (P0C449)
Organism: Oryza sativa (Rice)
Function: Binds to 23S rRNA.
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MDGIKYAVFTEKSLRLLGKNQYTFNVESGFTKTEIKHWVELFFGVKVVAVNSHRLPGKGRRMGPILGHTMHYRRMIITLQPGYSIPLLDREKN
Protein: Fibronectin-binding protein (Q93ED6)
Organism: Streptococcus equi subsp. equi
Interaction partners:
Sequence:
MKTKSFRKVLTTSATCIVLATSFAGGTLRVWAEQLYYGWNDGTRQSSPYFLYVSPKNAPKRELKDEYVVYCFNKKLYWPDQWESIYSNFNDIRSPYNDLPVYEKKLGYDGIFKQYAPDYKKDISDIASALVAVLSNGYPTNKSQLSTSYHLNNDSSRKVTQLAIWYFSDSLTKEYLKDTGGYNLNDMEKKALDFLISKGEDSKLKSEQSNYSLDIYVYQSGGHDHMKDYQNLLGSTLIPKEPLKPQLGGFSGHNGNGLSGLEGGSSGSQETNEDGKKGLIGFHGGLSGSEGKRDPFQD
Protein: tRNA (guanosine(18)-2'-O)-methyltransferase (EC 2.1.1.34) (tRNA [Gm18] methyltransferase) (P0AGJ2)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA. Type II methylase, which methylates only a subset of tRNA species.
Interaction partners:
- ATP-dependent DNA helicase RecG
- Bifunctional
- DNA-directed RNA polymerase subunit omega
- tRNA
- tRNA
- tRNA
- tRNA
- Ribosomal RNA large subunit methyltransferase H-methyltransferase)
- tRNA pseudouridine synthase B
- 23S rRNA
Sequence:
MNPTRYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMASAAAGSNSWVQVKTHRTIGDAVAHLKGQGMQILATHLSDNAVDFREIDYTRPTCILMGQEKTGITQEALALADQDIIIPMIGMVQSLNVSVASALILYEAQRQRQNAGMYLRENSMLPEAEQQRLLFEGGYPVLAKVAKRKGLPYPHVNQQGEIEADADWWATMQAAG
Protein: Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) (P35610)
Organism: Homo sapiens (Human)
Function: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10438503, ECO:0000269|PubMed:16154994}; Multi-pass membrane protein {ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614}.
Interaction partners:
- 7-dehydrocholesterol reductase
- Delta
- Sterol O-acyltransferase 2
- Cholesterol 24-hydroxylase
- Cholesterol 25-hydroxylase
- Cytochrome P450 7A1
- Sterol 26-hydroxylase, mitochondrial
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Steryl-sulfatase
- Sulfotransferase 2B1
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
Protein: Protein bdm (Biofilm-dependent modulation protein) (P76127)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Stationary-phase-induced ribosome-associated protein
Sequence:
MFTYYQAENSTAEPALVNAIEQGLRAQHGVVTEDDILMELTKWVEASDNDILSDIYQQTINYVVSGQHPTL
Protein: High affinity transport system protein p37 (P15363)
Organism: Mesomycoplasma hyorhinis (Mycoplasma hyorhinis)
Function: P37 is part of a high-affinity transport system.
Subcellular location: Cell membrane; Lipid-anchor.
Interaction partners:
Sequence:
MLKKLKNFILFSSIFSPIAFAISCSNTGVVKQEDVSVSQGQWDKSITFGVSEAWLNKKKGGEKVNKEVINTFLENFKKEFNKLKNANDKTKNFDDVDFKVTPIQDFTVLLNNLSTDNPELDFGINASGKLVEFLKNNPGIITPALETTTNSFVFDKEKDKFYVDGTDSDPLVKIAKEINKIFVETPYASWTDENHKWNGNVYQSVYDPTVQANFYRGMIWIKGNDETLAKIKKAWNDKDWNTFRNFGILHGKDNSFSKFKLEETILKNHFQNKFTTLNEDRSAHPNAYKQKSADTLGTLDDFHIAFSEEGSFAWTHNKSATKPFETKANEKMEALIVTNPIPYDVGVFRKSVNQLEQNLIVQTFINLAKNKQDTYGPLLGYNGYKKIDNFQKEIVEVYEKAIK
Protein: CUGBP Elav-like family member 4 (K7EJ26)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAGPAYPAAYGQISQAFPQPPPMIPQQQREGFVSFDNPASAQTAIQAMNGFQIGMKRLKVQLKR
Protein: BTB/POZ domain-containing protein kctd15 (Potassium channel tetramerization domain-containing protein 15) (Q6DC02)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8K0E1}.
Interaction partners:
Sequence:
MSRLSLTRSPVSPLAAQGIPLPAQLTKANAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTCKLLLPDDFKDFNLLYEEARYYQLSPMIKELERWKQEREQRRLANPCDCLVVRVTPDLGERIALSGEKVLIEEIFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVLERLFQKGFNVAASCGGGVDSSQFSEYVLCREDRRSHNTNTPIRIKQEPLD
Protein: Probable 26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit rpt-4) (Proteasome regulatory particle ATPase-like protein 4) (O17071)
Organism: Caenorhabditis elegans
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome non-ATPase regulatory subunit 1
- 26S proteasome regulatory subunit 7
- Proteasome subunit alpha type-4
- PCI domain-containing protein
- 26S proteasome non-ATPase regulatory subunit 3
- Probable 26S proteasome regulatory subunit 4
- Probable 26S proteasome regulatory subunit 6B
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 14
Sequence:
MLLLQFSNMVEPTGPAIVEDERTKALNSYRRKLAECRDIEQKLKDLRKKESEMTKQFDKSENDIKSLQSVGQIVGEVLKQLSEEKFIVKATNGPRYVVGCRRSINKEELKQGTRVSLDMTTLTIMRQLPREVDPLVYKMSHEDPGNISYSDVGGLAEQIRELREVVELPLINPELFKRVGITPPKGCLLFGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDSLGKVKVIMATNRPDTLDPALLRPGRLDRKIEIGLPNEQSRLEILKIHSNKITKHGEIDFEAVVKLSDGFSAADLRNVCTEAGMFAIRAEREFVIDEDFMKAVRKVGDAKRLETKLDYKPV
Protein: Allatostatin-A (Allatostatins Ast) [Cleaved into: Drostatin-1 (AST-A1); Drostatin-2 (AST-A2(14-21)); Drostatin-3 (AST-A3); Drostatin-4 (AST-A4); Drostatin-5 (AST-A2(1-11))] (Q9VC44)
Organism: Drosophila melanogaster (Fruit fly)
Function: May act as a neurotransmitter or neuromodulator.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Short neuropeptide F
- Tachykinins
- Neuropeptide F
- Allatostatin C, isoform A
- Cardioactive peptide
- Leucokinin
- Adipokinetic hormone
- Allatostatin A receptor 2, isoform A
- Diuretic hormone 44, isoform A
- Allatostatin A receptor 1, isoform B
Sequence:
MNSLHAHLLLLAVCCVGYIASSPVIGQDQRSGDSDADVLLAADEMADNGGDNIDKRVERYAFGLGRRAYMYTNGGPGMKRLPVYNFGLGKRSRPYSFGLGKRSDYDYDQDNEIDYRVPPANYLAAERAVRPGRQNKRTTRPQPFNFGLGRR
Protein: Alpha-galactosyl-binding lectin (A7UNK4)
Organism: Lyophyllum decastes (Fried chicken mushroom)
Function: Alpha-galactosyl-binding lectin with preference for galactose-alpha-1,4-galactose.
Interaction partners:
Sequence:
ACWKANSCPGSAFESKDRLRSFALLYCRYNYKPPYGQGAFGYASAVSTHGWETEAQCINTFEQIITSCHGQSNGGTLELNSGRLSLAFGNCEEL
Protein: Putative outer membrane protein (B6ENQ5)
Organism: Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Interaction partners:
Sequence:
MIELWEKHTILAEQSFKNEDFWRTILHYQQAYAISEELSKRNEGSLADQTTISIISCHNLAQFWRSQNDNQFELKYLQIASEKVLTLVPQCPRSDCESFISNLGCCKNALLDFMKRHPNPAIARHIQHIDHTVQCELIASFKLQ
Protein: LD30746p (Logjam, isoform D) (Logjam, isoform E) (Logjam, isoform F) (Q9VRU2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037847}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037847}. Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}.
Interaction partners:
- Transmembrane emp24 domain-containing protein bai
- Transmembrane emp24 domain-containing protein eca
- LP01981p
Sequence:
MQLTWQRDQINLVLPIALICCCLLIDVTSAQEAQQPWYENLPAVAMDYKVHIDAGKEDCYHQYVKAGATFYVSFSVVRGGDGMAGFAVRNPAGEVVKPYQWQATADYTDQVSPGGYYSVCIDNQFSRFAGKLVNIYITVVKYDAWDKYAKEIEQLQLNMQNFTATVGTVERNINDMMGYQAHSRHRESRDYALLLDNNAYIQTFSISQIVVILITCSVQVFFVRKLFEVKSSSKSRI
Protein: Immunodominant antigen, putative (Q57UM8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTITVDLFGEADCNDGEGHMWSADVAKFTEVPEVPRVFADSQHYITYTTKKGNSLRVVKRLNLARGTVRGHTTPIHSVRFVNYRSNVAASASKGEFFVWVVTDSGEGGTGRPSADAELTINMYFRLSDPVTISCFSFFINAENKRPDVLVLHDQQASILDSSALIALYRDTPLTATLKQNSTALRKLASNVTANTLCSVGSGGWFAFTTDSNMVAACTLQNRNTPPWSCCEGAPVHSLHLLDTPHAEKTTLVASCSRVVYQWSLSGASEPTLLRKFAVDGTIVSLEGSRDSFAVFNDKRKLAVVRIQSPKEFTCTRYTLPWQVRRRGTCFNCVGGESYIMADNDDRLTVMQLKANASSGAGKRESPLNTRRSPAGAAKPASNVLAPTTGTKIKSNSSTQPTGSIIANLVNRLGICSVGMAPPASSNTSSPATATATGSAPDVTSASANATQRGALHGYSNQPVTAGLGSGSSAGASKVFTPALSKSLAASAGRGHGSSSISPASAQLSAAVNANNLTHSSRPALHNASLPQAPTDGVLATVLQQTEDEVHQELERLDSVMKNTLQVLQLTPDTIHRAHEQLLSLSLEAQMTELQQQQERQKNASLSNSAGFTPFETCVLLSILDPLSQSIANGLTRGVEDAMMANLEHGVRHALVNRARTTQKSAMKARLDEVLKESSSQFLAQVEQTVRNVVENELAEVFGDINGLLTALENDNVRLQRELEAIMASDVITEMKKTREELESLREAVTNQQLAIGTGSQLVSRPSPETVLSTTTELIQQQQYRQGLEYIIMAEQPQLVLQLFVALKKKTENVYSALIEDPATPNDVWLRVIVQITGAATSEKDIDAVVGVLIDILSEREQLLQKTGPTAKLTESLHSFVTVGKSGRKCSAGLRNFKNLEKLLP
Protein: Small ribosomal subunit protein uS7z (40S ribosomal protein S5-1) (AtRPS5B) (Q9ZUT9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS1z
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein uS12z
- Small ribosomal subunit protein uS13z/uS13y/uS13x
- Small ribosomal subunit protein uS15y
- Small ribosomal subunit protein eS28x
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein eL8z
Sequence:
MAASAEIDAEIQQQLTNEVKLFNRWSFDDVSVTDISLVDYIGVQPSKHATFVPHTAGRYSVKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVKHAMEIIHLLSDLNPIQVIIDAIVNSGPREDATRIGSAGVVRRQAVDISPLRRVNQAIFLLTTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDEIERVAKANR