wanglab/gogpt-training-data huggingface dataset:
Protein: Delta(14)-sterol reductase (EC 1.3.1.70) (C-14 sterol reductase) (Sterol C14-reductase) (Q54PP1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable lanosterol 14-alpha demethylase
- Putative methylsterol monooxygenase DDB_G0269788
- Probable 3-beta-hydroxysteroid-Delta
- Delta
- Protein erg2 homolog
- Sterol desaturase family protein
- Putative methylsterol monooxygenase DDB_G0270946
Sequence:
MSAVRNRNNVEKQSNNGAQLTEVQKKELADLQKVHPANEFGGIIGTFLLTFILPVVVYWIWASIEFNNGYLLRPETLSVEGVKAFLAQLYHYVITYAYPTKEAAIIYFSWFGFQAFLQHVVPGRKVLGSPLPGGARLEYTLNGWASWWITLIVIPIAIYFGLFKATILIDNYAPMMTVVNIWSFVFTFLLKIHAKLKGEEERMSGHFFYDFWMGFARNPRIGSFDLKLFCEARPGLILWVLMNFSIAAKQLEVYGEISLSVILVCCFHFWYIADYYYHEEAILTTMDIITEKFGYMLVYGDLSWVPFTYCFQCYYLYKHLVNGAPLHISIGYAIFVVSLKCFGFYLFRWVNSQKHDFRRNPEAPVWGKPAEFILTKRGTKLLCSGFWGICRHLNYTGDIILSWAWCLPCQFDSLAPYFYGIYFTSLDLHRCWRDHNACLVKYGDDWRAYCKRVPYNFIPGLI
Protein: A disintegrin and metallopeptidase domain 3 (Cyritestin) (F8VQ03)
Organism: Mus musculus (Mouse)
Function: Involved in fertilization by controlling sperm migration into oviduct.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15514464}; Single-pass membrane protein {ECO:0000255}. Note=Localized in round and elongating spermatids. Localized on the anterior part of the sperm head, and is removed during the acrosome reaction. {ECO:0000269|PubMed:15514464}.
Interaction partners:
- Protein disulfide-isomerase-like protein of the testis
- A disintegrin and metallopeptidase domain 4
- Zona pellucida sperm-binding protein 3 receptor
- Calmegin
- Calreticulin-3
- Probable inactive serine protease 37
- Izumo sperm-egg fusion protein 1
- Zona pellucida-binding protein 2
Sequence:
MLPLFLVLSYLGQVIAAGKDVETPLLQITVPEKIDTNIQDAKEAETQVTYVVRIEGKAYTLQLEKQSFLHPLFGTYLRDKLGTLQPYFSLVKTHCFYQGHAAEIPVSTVTLSTCSGLRGLLQLENITYGIEPLESSATFEHILYEIKNNKIDYSPLKENFANSEQESQSYRILVKPEKGSNSTLTKRILRIKIIMDKAMFDHMGSEVGVATQKVVHIFGLINTMFSQLKMTVMLNSLEIWSEQDKIETNGDADEVLQRFLLWKSKEISQKAQDITYLLLYKDHPDYVGATYHGMACNPNFTAGIALHPKTLAVEGFAIVLSQLLGINLGLAYDDVYNCFCPGSTCIMNPSAIRSQGIKVFSSCSVDEFKQLASQPELDCLRNTSETEFVVQPQGGSYCGNHLLEVPEQCDCGPPETCTHKKCCNPKDCTLIDAAQCGTGPCCDKRTCTIAERGRLCRKSKDQCDFPEFCNGETEGCAPDTKAADLEPCNNETAYCFGGVCRDPDRQCTDLFGKYAKGPNYVCAQEVNLQNDKFGNCHGRCNYSAIFCGKAVCYWNFAEVIQTEKYDVQYTYLGGQVCVSAHLRSQTGTRDDTYVHDGTVCGSGQVCFRGDCLRVHVLRGTRECEADDKCQGHGICNNLNNCQCESGFAPPECDMTPSSPGGSMDDGFWLPFDKSTPLIFKRHGLKYKKVLLISFYILLPFLVVLAFMAVKRMIGKRLAKQNISKALEHKEEAFNRGSMNPGVVSGGNTDQNLMTVPGSFNSYAYHGNTDQNFMTVPGSFNSYSYHGNTDQNFMTVPGSFNSYSYQDVPYYRSIPEDGNDSQQ
Protein: Cyclin-dependent kinase B1-1 (CDKB1;1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog B) (P25859)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May control G2/M (mitosis) phase progression. Plays a role in regulating seedling growth in darkness via regulation of hypocotyl cell elongation and cotyledon cell development. Plays a role in stomatal development. Required to suppress endoreduplication. Together with CDKB1-2, promotes both the last division in the stomatal cell lineage as well as the number of stomata. In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage.
Subcellular location: Nucleus {ECO:0000269|PubMed:20675570}.
Interaction partners:
- Cyclin-A2-3
- Cyclin-dependent kinases regulatory subunit 1
- Retinoblastoma-related protein 1
- Cyclin-dependent kinases regulatory subunit 2
- Cyclin-B1-2
- Cyclin-D4-1
- Cyclin-A2-1
- Cyclin-A1-1
- Cyclin-A2-4
- Cyclin-A2-2
Sequence:
MEKYEKLEKVGEGTYGKVYKAMEKGTGKLVALKKTRLEMDEEGIPPTALREISLLQMLSTSIYVVRLLCVEHVHQPSTKSQSTKSNLYLVFEYLDTDLKKFIDSYRKGPNPKPLEPFLIQKLMFQLCKGVAHCHSHGVLHRDLKPQNLLLVKDKELLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEVLLGSTHYSTGVDMWSVGCIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPTEQQWPGVSTLRDWHVYPKWEPQDLTLAVPSLSPQGVDLLTKMLKYNPAERISAKTALDHPYFDSLDKSQF
Protein: LONGIFOLIA protein (A8MQH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g26910
- DUF3741 domain-containing protein
- AT5G44290 protein
- Protein TRM32
- Phosphatidylinositol N-acetyglucosaminlytransferase subunit P-like protein
- tRNA
- Serine-rich adhesin for platelets-like protein
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- tRNA
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
Sequence:
MELVLFLLGIYWKHNKEELRHCHYREKSSNSLLFVTSSKFRRRRFAGEPSWFQKKIGCMNGIFQIFDRHHILTSRRKSLTLGNAHVNSINFERDSVDAICQQRSAFQCQDSNLVSSNGLSEKLTRLSTECSRVSFSSSCSSSSPLSSEVNREVQPEISADDRVIFPESPTSDPVMSQGTGARVGLDLRDVVRDSMYREARGLSDVCRQNRREDSPRPYGLKQSRPVDFNESCRALAKLRKTSHHYYNEVDMKDTSRYYVDSRGKSKSGKKLKELPRLSLDSRDHVDLKSGNKLSESFSRSSSMNKVSGSPKRPPSVVAKLMGLETLPGSPLSRDRFNMFDDNSDPFARSLRENSLNRSLRFSPSSPRSLGKDPAASSSSPRWRSSEFVMKPLSSLRYPIEPAPWKQTERNRFSQKQACRSVKSLSQSMEGKLKDLEVKHSGKDLRALKDILEAMQSKGLFDTRKQQQCSNLEAQRDYELADSATSKHDSIDLRNPVIPSNMRGPIVIMKPARLVEKSGIPSSSLIPIHSLSGLNKTCREEPVNVRRSSTSRKAVKDRSPGNQRAEPCISSDKKSSSRNVMSSQVYKESTSKNSGPASSKLQQMKPEHDKRSRPPASPSDSSKLRKQISRQPVESTTSPGGRRSRPRDQRSLQQNDGQLSQMSNKSRTKIEATLSIENGGKSPSVIEAAKAVVSNLIQNKSSPTFSEDGSSEHPSPVSVLNAEIYREIEPSPVKIQASEGSVNGSINSGVEHCEEDQWNPAYSFSKTTTSFSPEMNRKKLQNVEHLVQKLKRLNSSHDETSQDYIASLCENSDPDTDHRYISEILLASGLLLRDLGSGLTTFQLHPSGHPINPELFLVIEQTKGCSSSSNEKINRKLVFDAVNEMLGKKLAFVESYVDPWMKQAKARKKVLSAQNLLKELCSEIEILQKQAKKRSENLLLLEEEEEEEEDFLKCILDEDMAIQSEKWTDFDDAIPGLVLDMERLLFKDLVKEIVHGEIDRLQGNSRRQKTVLADE
Protein: FI16614p1 (Q9VMU7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RE55691p
Sequence:
MSDFEYGICPYDKSHRILLFRMPKHLIKCEKNYCGPPLQTCKYNATHRVQDMEKHLKECDYYLRSIENQAVQIALRSRIPPKQEDGHDVDTPF
Protein: WRKY transcription factor 6 (WRKY DNA-binding protein 6) (AtWRKY6) (Q9C519)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor involved in the control of processes related to senescence and pathogen defense. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Activates the transcription of the SIRK gene and represses its own expression and that of the WRKY42 genes. Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223, ECO:0000269|PubMed:11722756}.
Interaction partners:
- High mobility group B protein 6
- Senescence-induced receptor-like serine/threonine-protein kinase
- Phosphate transporter PHO1
- Mitogen-activated protein kinase 6
- Inorganic phosphate transporter 1-1
- Regulatory protein NPR1
- Mitogen-activated protein kinase 3
- Transcription factor MYB62
- F22C12.10
- Senescence-specific cysteine protease SAG12
Sequence:
MDRGWSGLTLDSSSLDLLNPNRISHKNHRRFSNPLAMSRIDEEDDQKTRISTNGSEFRFPVSLSGIRDREDEDFSSGVAGDNDREVPGEVDFFSDKKSRVCREDDEGFRVKKEEQDDRTDVNTGLNLRTTGNTKSDESMIDDGESSEMEDKRAKNELVKLQDELKKMTMDNQKLRELLTQVSNSYTSLQMHLVSLMQQQQQQNNKVIEAAEKPEETIVPRQFIDLGPTRAVGEAEDVSNSSSEDRTRSGGSSAAERRSNGKRLGREESPETESNKIQKVNSTTPTTFDQTAEATMRKARVSVRARSEAPMISDGCQWRKYGQKMAKGNPCPRAYYRCTMATGCPVRKQVQRCAEDRSILITTYEGNHNHPLPPAAVAMASTTTAAANMLLSGSMSSHDGMMNPTNLLARAVLPCSTSMATISASAPFPTVTLDLTHSPPPPNGSNPSSSAATNNNHNSLMQRPQQQQQQMTNLPPGMLPHVIGQALYNQSKFSGLQFSGGSPSTAAFSQSHAVADTITALTADPNFTAALAAVISSMINGTNHHDGEGNNKNQ
Protein: Klra21 protein (Q14B13)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSEQEVTFPTMRFHKSSGLNSQVRLEGTQRSRKAGLRVPWQLIVIALGILCSLRLVIVAVFVTKIFQYSQHKQEINETLNHHHNCSNMQRDFNLKEEMLTNKSIDCRPSYELLEYIKREQDRWDSETKTVLHSTQNTGRGVKYWFCYSTKCYYFIMNKTTWSGCKANCQHYSVPIVNIEDEDELKFLQRHVITEGYWIGLSYDKKKKEWAWIDNGQSKLDMKIRKMNFKSRGCVFLSKARIEDTDCNIPYYCICGKKLDKFPD
Protein: Cys-Gly metallodipeptidase dug1 (EC 3.4.13.-) (GSH degradosomal complex subunit DUG1) (Q9P6I2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Has a Gly-Cys dipeptidase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative aminopeptidase C13A11.05
- Glutathione hydrolase proenzyme 1
- Glutathione synthetase large chain
- Glutamate--cysteine ligase
- Putative glutamate--cysteine ligase regulatory subunit
- Glutathione hydrolase proenzyme 2
- Glutathione-specific gamma-glutamylcyclotransferase
- Uncharacterized protein C11D3.14c
- Protein arg11
- Homocysteine synthase
Sequence:
MKMSLDKLYEVIDKKKDEFVTRLSRAVSIPSVSADVTLRPKVVEMADFVVSEFTKLGAKMEKRDIGYHQMDGQDVPLPPIVLGQYGNDPSKKTVLIYNHFDVQPASLEDGWSTDPFTLTVDNKGRMFGRGATDDKGPLIGWISAIEAHKELGIDFPVNLLMCFEGMEEYGSEGLEDLIRAEAEKYFAKADCVCISDTYWLGTKKPVLTYGLRGVCYFNITVEGPSADLHSGVFGGTVHEPMTDLVAIMSTLVKPNGEILIPGIMDQVAELTPTEDSIYDGIDYTMEDLKEAVGADISIYPDPKRTLQHRWRYPTLSLHGIEGAFSGSGAKTVIPAKVIGKFSIRTVPNMESETVERLVKEHVTKVFNSLNSKNKLAFNNMHSGSWWISSPDHWHYDVGKKATERVYGITPDFVREGGSIPVTVTFEQSLKKNVLLLPMGRGDDGAHSINEKLDLDNFLKGIKLFCTYVHELASVSP
Protein: Mitochondrial carrier protein, putative (Q57ZL4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
Sequence:
MVSEGTSAAGRLEGESPLALRVDTGEIVAGCLAGFVEHFFMFPFDTLKTRVQSGDSTNVILAAKRISRNERLAHLYRGFAPIIVSAVPAHGAYYSTYEAAKRVFGEDSTVSITVSASCAVAAHDTISTPFDVIKQRMQMDGSRKFASSLQCGQCAVAEGGVRCLLLSLPTTILMNIPHFSAYWLVYEGFLAYLGGERRNRETEVAGDYITGGLLAGTVASIVSSPLDVVKTQLQLGLRKNIPDAVRYVLVNRGTKGFFAGVTARVMCTAPAGALSMITYETAKKFMEER
Protein: Coiled-coil domain-containing protein 134 (Q9H6E4)
Organism: Homo sapiens (Human)
Function: In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. Has a critical role in the regulation of osteogenesis and bone development.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:39509507, ECO:0000305|PubMed:18087676}. Secreted {ECO:0000269|PubMed:18087676}. Cytoplasm {ECO:0000269|PubMed:22644376}. Nucleus {ECO:0000269|PubMed:22644376}. Note=Mainly localizes to the endoplasmic reticulum (PubMed:39509507). Accumulates in the nucleus in response to UV irradiation (PubMed:22644376). {ECO:0000269|PubMed:22644376, ECO:0000269|PubMed:39509507}.
Interaction partners:
Sequence:
MDLLQFLAFLFVLLLSGMGATGTLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHVVENTAFFGDVVLRFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL
Protein: Histone H2A-like 1 (H2A.L.1) (H2AL1) (Histone H2Alike 1) (Q5M8Q2)
Organism: Mus musculus (Mouse)
Function: Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000269|PubMed:17261847}. Chromosome {ECO:0000269|PubMed:17261847}. Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). {ECO:0000269|PubMed:17261847}.
Interaction partners:
- Histone H2B type 1-A
- H2A histone family member L3
- Histone H1.9
- Huntingtin-interacting protein M
Sequence:
MAKKMQRRRRQKRTRSQRGELPFSLVDRFLREEFHSSRLSSSALSFLTSVLEYLTSNILELAGEVAQTTGRKRIAPEDVRLVVQNNEQLRQLFKPGGTSVNEDDN
Protein: Calcium-dependent secretion activator (H9G2V2)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MLGASSSEEEDDDFQEDHDSLPIAQVKKRSLLSGAMTPRSSSPAPSDSVSQTNSLKRNNSSSQGRRKDSVQSQTPARSARIMSNVSKPIMQNSQEFDGDEEEGEEGSTTVVGSGDECGGPALSKEEQERMKAEREEEDHKKNLQMYMFLARCIAYPFNGQQTGDMARRQMKVNKQELARIRERFTLFLKGETNIAADEAFTKAIQSYFEVFLKSERVQKVVHAGGFSQHDFREVFRLNIEKRVRSLPDIEGLSKDTVLNSWLAKFDAIIKGDETDQNRNARGRSRNPQNAMSADAVLGKEQLYDVFQQILGVKKFEHQIIFNALQLDNPDEQAAAIRREFATREEALKDPIKMKRLTPKFVVKDMETLYMDEVRMSINTLIGNLETVPVTTRGATVGKRKDKSRNQTKNKRSRSIEDLSLFNSLKRRTSSGSLNKGDSEDGDVTLTKSDVSLALSMEVVVMEVQGLKSVQPSKIVYCTMEVDGHKLQTDHAEASKPKWDTQGDFSTKNPLPVVKVKLYTEVKSMIAFEDKELGKVIIQPTPNCARSPEWYTMTLPKSSQDQNLKIRIAIRVEKPPNLKYCGYCYCIGRNAWKKWKKRFFCLVQVSQYAFAVCSFRQKKADPTEFIQLDGFTIDYMPESDPELSAQGGKHFFTAIKEGDELKFATDDENERHLWVQALYRATGQAYKPVPPKQSTIAPKAQGFQDKASKHGMDAMIQADSINFDHDHFYSDVQRLTLDFRINEPICSLGWFSPGQAFVLEEYSARYMVRGCFRHVTLLSNLLDKADDGLLIDPALIHYSFAFCASHVHGNRCMPDRQGPEGVGTVTLEEKEKFQEIKERLRVLLEKQITNFRYCFPFGRPEGALKGTLGLLERVLMKDVVSPVPPEEVRAVIRKCLEDAALVNYTRICNEAKIEQRMGIDVSPAQRIEDMIRVTEFCIDLLKENEEHHGEAFAWFSDLLSDHSEIFWSLYSVDLDSALEVQPHDSWDSFPLFQMLNDFLLSESSLKGGIFHNKIVQQFQPLVVRYIDLMEHSIAQAIDKGFSKEKWESRKEGCATSEDIYWKLDALHTFVIDLNWPEEDFRKYLQTKMKSLTSDMISKVSDCTFTAFDSWMQRAKKSTDYMLPSEVCVQINVMFSSKSRAVRVTVDSGEYKYQSKLDETLETMLKTMESCIQEKLHGVLESVLSRLARYDEGNPIGAILNIAPKPASIFNKLKTMAGDTSAQATTTARQPLTAQQSSGQIGNSYVTFFHGCTELLRQVIIDEIWVNGLFEHWYDNQMKSINEWLTERLQQSLSATQYISLSTIVKKVYQDFSLQGIDEERLNSKTYQSISRRLQLEESNSHIQEAAINGSAQGSVFPTSLGNATAAVSNMSSMVEGAGAKMFSLFK
Protein: ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) (P47857)
Organism: Mus musculus (Mouse)
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, cilium, flagellum {ECO:0000269|PubMed:19889946}. Note=Principal piece region of the sperm flagellum. {ECO:0000269|PubMed:19889946}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell projection, cilium, flagellum {ECO:0000269|PubMed:19889946}. Note=Principal piece region of the sperm flagellum. {ECO:0000269|PubMed:19889946}.
Interaction partners:
- Glucose-6-phosphate isomerase
- Fructose-bisphosphate aldolase A
- ATP-dependent 6-phosphofructokinase, platelet type
- Fructose-bisphosphate aldolase B
- Hexokinase-2
- ATP-dependent 6-phosphofructokinase, liver type
- Hexokinase-1
- Fructose-bisphosphate aldolase C
- 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 splice variant 2
- Hexokinase-3
Sequence:
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRPPVSKGGLHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHISRKRSGEAAV
Protein: T-cell surface glycoprotein YE1/48 (Lymphocyte antigen 49a) (Ly-49a) (T lymphocyte antigen A1) (P20937)
Organism: Mus musculus (Mouse)
Function: Receptor on natural killer (NK) cells for H-2d alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- H-2 class I histocompatibility antigen, D-B alpha chain
- Beta-2-microglobulin
- H-2 class I histocompatibility antigen, K-B alpha chain
- TYRO protein tyrosine kinase-binding protein
- Histocompatibility 2, M region locus 3
- Natural killer cells antigen CD94
- Partner of Y14 and mago
- Killer cell lectin-like receptor subfamily B member 1C
- Natural cytotoxicity triggering receptor 1
- GTP-binding protein GEM
Sequence:
MSEQEVTYSMVRFHKSAGLQKQVRPEETKGPREAGYRRCSFHWKFIVIALGIFCFLLLVAVSVLAIKIFQYDQQKNCEEFLNHHNNCSNMQSDINLKDEMLKNKSIECDLLESLNRDQNRLYNKTKTVLDSLQHTGRGDKVYWFCYGMKCYYFVMDRKTWSGCKQACQSSSLSLLKIDDEDELKFLQLVVPSDSCWVGLSYDNKKKDWAWIDNRPSKLALNTGKYNIRDGGCMLLSKTRLDNGNCDQVFICICGKRLDKFPH
Protein: Transducin/WD40 repeat-like superfamily protein (F4HUT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MWEAIKDRETGRIRSNSFANRFKSRRILSLQLSNRKDFVSPHRGSVNSLQVDLTEGRYLLSGAADGSAAVFDVQRATDYEASGLIAKHKCIFTVDKQHENGHKYAISSAIWYPIDTGLFITGSFDHYLKVWDTNTAQAVVDFKMPGKVYRTAMSSMAMSHTLIAAGTEDVQVRLCDIASGAFSHTLSGHRDGVMSVEWSTSSEWVLYTGGCDGAIRFWDIRRAGCFRVLDQSQTQLGFRPPILKRTAVGSKLSSVAKSSLGGQNRLKTLQSKQTGSQSVKGSSSAKASVEKSRQKRIHPGMLSTLDRATAHYGAVTGLKATNDGMYLLSAGSDSRIRLWDIESGRNTLVNFETGRIQTNKGIQLDTSDDPALVFVPCMKTVKVAFGMWSGRTTLMLRGHYESVNTCCFNSNDQELYTSGSDRQILVWSPGGTVEDEMVQDEVAEDKDNWSD
Protein: Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1) (Q9CRC0)
Organism: Mus musculus (Mouse)
Function: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BQB6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BQB6}.
Interaction partners:
- Vitamin K-dependent gamma-carboxylase
- NAD
- Vitamin K epoxide reductase complex subunit 1-like protein 1
Sequence:
MGTTWRSPGLVRLALCLAGLALSLYALHVKAARARDENYRALCDVGTAISCSRVFSSRWGRGFGLVEHMLGADSVLNQSNSIFGCLFYTLQLLLGCLRGRWASILLVLSSLVSVAGSVYLAWILFFVLYDFCIVCITTYAINVGLMLLSFQKVPEHKTKKH
Protein: Zinc-ribbon domain-containing protein (Q381D9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTETDGGLKTEAVPLSRMATSVRQYDEGSCSVLIPQGDFNDSVTNPIIHLEQPPSRHSPYDMESRKVSPFRPTPSTLHRMDTTIDSTIDADANDDSISLVSRLSYSRRRRRRDFCGPVDAAEEERQRQELEKALKNLEEMQRENKERMMRIGSTMASTHSAHTTGRRASYDDQGPEQYLRTQSVGVHLTREVLRLQMFERAATSLTVPDPLMEAINSSRRQRCKGSANKLTSPKTKRNGLWMASSNKKNGESPARQSQCLAPNSLATCASAESLSVKKDVNAGKNPPAATQVLTTSKELTAEQHYGNGKATVANGGGRANNGNNRGMNSSVSPASSKDDPQDQLLSSAGDVKSVKRAGNQGKRTVGGGRPSSGRPSGRSSSPPIIILTVDARRHMGEEDARRLLSAKPLEGYESHSHLRHSMDTSVLSNTTVKRAAPHASKATEPFAPMPSTVIAERESESRGKVTPPEVRRNRQTSETRTSPVSTIALTPASHADGFLTRDEVNRKSGSVQLHLQTTQQPLTKNQSATTTATSPQAEKKKKVSQAGVATRTQQPAKQRSGKVTNASLKSPGGSAGDGKVKPLRTQIQPTAGTARTERRNGVVHRSSFPRTGVEPLTQQRTIINFGSSHNQTSPLSHGESPYPIYDKDGRRVKNSHYKLGQTTVTNTTTTTATASNAPVVTATANAAVVAVTTVRQRSTVGNLKIRRKSFTSLSPTASTERESMRPLATDRPQATTLNTVRCVAPAQQQPTKQLVPFCTECGKRHLDDKVKFCAFCGHKRELA
Protein: Oligouridylate-binding protein 1B (AtUBP1b) (Polyuridylate-binding protein UBP1B) (Poly(U)-binding protein UBP1B) (Q9LQI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Heterogeneous nuclear ribonucleoprotein (hnRNP)-like protein that acts as a component of the pre-mRNA processing machinery. Functions to facilitate the nuclear maturation of plant pre-mRNAs (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- tRNA/rRNA methyltransferase
- Zinc finger A20 and AN1 domain-containing stress-associated protein 3
- Ubiquitin carboxyl-terminal hydrolase 1
- Large ribosomal subunit protein uL13y
- Large ribosomal subunit protein eL15y
- Chaperone DnaJ-domain superfamily protein
- Nuclear transport factor 2
- mRNA-decapping enzyme-like protein
Sequence:
MQRLKQQQQQQQVMMQQALMQQQSLYHPGLLAPPQIEPIPSGNLPPGFDPSTCRSVYVGNIHIQVTEPLLQEVFAGTGPVESCKLIRKEKSSYGFVHYFDRRSAGLAILSLNGRHLFGQPIKVNWAYASGQREDTSSHFNIFVGDLSPEVTDAMLFTCFSVYPTCSDARVMWDQKTGRSRGFGFVSFRNQQDAQTAIDEITGKWLGSRQIRCNWATKGATSGEDKQSSDSKSVVELTSGVSEDGKDTTNGEAPENNAQYTTVYVGNLAPEVSQVDLHRHFHSLGAGVIEEVRVQRDKGFGFVRYSTHVEAALAIQMGNTHSYLSGRQMKCSWGSKPTPAGTASNPLPPPAPAPIPGFSASDLLAYERQLAMSKMAGMNPMMHHPQGQHAFKQAAMGATGSNQAIYDGGYQNAQQLMYYQ
Protein: Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (Protein trf-proximal) (dMED20) (dTrap26) (dTrfp) (P91641)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA gene.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 29
- Mediator of RNA polymerase II transcription subunit 14
Sequence:
MGVTILQPYPLPEGKSGAHIIDQLSKRLLALGATHAGQFLVDCETFISTPQPHNGAPGRAVHVLHNSEYPASTFSIIDNGTGKQVAIVADNIFDLLMLKMTNTFTSKKQTKIESRGARFEYGDFVIKLGSVTMMEHFKGILIEIEYKSCVILAYCWEMIREMLQGFLGIAVNKDFPSYFAPQTIMTAMGQQQLHAKHNDIFEPMDTVKQYLEQFTNYRKHVTLMGGMGSGPGSQQVGPNVHMSPAVAGLHRS
Protein: Prothymosin alpha (B8ZZA1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNPCVLGTVPACRLTWPTDAGPDDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD