wanglab/gogpt-training-data huggingface dataset:
Protein: Arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) (P9WFW5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Glutamate--tRNA ligase
- Leucine--tRNA ligase
- Isoleucine--tRNA ligase
- GMP synthase
- Valine--tRNA ligase
- Tyrosine--tRNA ligase
- Methionine--tRNA ligase
- Proline--tRNA ligase
- Histidine--tRNA ligase
- Cysteine--tRNA ligase
Sequence:
MTPADLAELLKATAAAVLAERGLDASALPQMVTVERPRIPEHGDYASNLAMQLAKKVGTNPRELAGWLAEALTKVDGIASAEVAGPGFINMRLETAAQAKVVTSVIDAGHSYGHSLLLAGRKVNLEFVSANPTGPIHIGGTRWAAVGDALGRLLTTQGADVVREYYFNDHGAQIDRFANSLIAAAKGEPTPQDGYAGSYITNIAEQVLQKAPDALSLPDAELRETFRAIGVDLMFDHIKQSLHEFGTDFDVYTHEDSMHTGGRVENAIARLRETGNIYEKDGATWLRTSAFGDDKDRVVIKSDGKPAYIAGDLAYYLDKRQRGFDLCIYMLGADHHGYIARLKAAAAAFGDDPATVEVLIGQMVNLVRDGQPVRMSKRAGTVLTLDDLVEAIGVDAARYSLIRSSVDTAIDIDLALWSSASNENPVYYVQYAHARLSALARNAAELALIPDTNHLELLNHDKEGTLLRTLGEFPRVLETAASLREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEQPTDLHTARLALCQATRQVIANGLAIIGVTAPERM
Protein: UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.-) (EC 2.5.1.39) (Protein barolo) (Protein reddish) (E7FB98)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development (By similarity). Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4 (By similarity). Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from nos3/eNOS-dependent oxidative stress.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y5Z9}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:23374346}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9Y5Z9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- 3-hydroxy-3-methylglutaryl coenzyme A reductase
- Procollagen C-endopeptidase enhancer a.
- Acyl-coenzyme A thioesterase 13
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Dehydrodolichyl diphosphate synthase complex subunit nus1
- Alkyl transferase
- 3-hydroxy-3-methylglutaryl coenzyme A reductase.
- isopentenyl-diphosphate Delta-isomerase
- Hydroxyacid oxidase
Sequence:
MQEMKPAALSGSNGLNGASGSSVRVPCSRLSRAGRMALDLQSKCAAYVLALRPWSFSASLTPVALGSALAYKLEGSVDLLLLLVCAVAVLLVHGAGNLVNTYYDFSKGIDHKKSDDRTLVDQILKPQDVVMFGAVLYSAGCLCATLLYFLSSLKLEHLALIYFGGLSSSFLYTGGIGLKYVALGDVVILITFGPLAVMFAHAVQVGYLSVLPLVYAVPLALNTEAILHSNNTRDMDSDKQAGIVTLAILLGPTLSYVIYNLLLFVPYLLFCILATRYTISMALPLLTLPMAFPLERQFRCRCYAKIPQKTAKLNLLMGLFYVFGIILAPQGSLPLL
Protein: Uncharacterized TLC domain-containing protein YPR114W (Q06107)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized membrane protein YPR071W
Sequence:
MDVLLSLPQPELFKTTVIPFLANRNIIKSEAILSNLHSIFYVAIFYHIWFLFGKWILFPHLVKWKLDYDQKHNVKKDEKTTSERQAQHYKKKYTSLINQSSVHLISLLQSIVVLYYSLKFLLDPKASAEPYQTSHSRVFTENRDTQVICIFAIGYFVWDIYISTMYSTFPFVVHGIISTVVFCIGLKPYIQYYAPVFLMFELSNPSLNFRWFGIKFLPQKSKFCSLLLLLNNLTLMVVFFAARIAWGWFQIGKLCYDFYQVRNEPGFLVFDTIVILAGNFVLDILNVIWFSTMVSVAAKVLKKGESVDKVTKNEQ
Protein: Chlorophyll a-b binding protein, chloroplastic (Q39142)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000256|ARBA:ARBA00004334, ECO:0000256|RuleBase:RU363080}.
Interaction partners:
- Chlorophyll a-b binding protein CP26, chloroplastic
- Chlorophyll a-b binding protein 3, chloroplastic
- Oxygen-evolving enhancer protein 1-1, chloroplastic
- Chlorophyll a-b binding protein CP29.1, chloroplastic
- Photosystem II CP43 reaction center protein
- Photosystem II CP47 reaction center protein
- Photosystem II protein D1
- Chlorophyll a-b binding protein
- Photosystem II D2 protein
- Expressed protein
Sequence:
MAASTMALSSPALTGKAVKLSPAASEVFGTGRITMRKASKPTGPSGSPWYGSDRVKYLGPFSGEPPSYLTGEFPGDYGWDTAGLSADPETFARNRELEVIHSRWAMLGALGCVFPELLARNGVKFGEAVWFKAGSQIFSDGGLDYLGNPSLVHAQSILAIWATQVILMGAVEGYRVAGDGPLGEAEDLLYPGGSFDPLGLATDPEAFAELKVKELKNGRLAMFSMFGFFVQAIVTGKGPLENLADHLADPVNNNAWAFATNFVPGK
Protein: RE25483p (Q7JW46)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
Sequence:
MSSNSLFETDEDVAQANKLSRKVKESPFMLVGIAGFVAAGLIGAYKYRNRGSMSTSVFLMQLRVAAQGTVVGCLTAGLAYTMAKEYLLHEEPKSNTRPDE
Protein: Ras-related protein Rab-35 (EC 3.6.5.2) (GTP-binding protein RAY) (Ras-related protein Rab-1C) (Q15286)
Organism: Homo sapiens (Human)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725, ECO:0000269|PubMed:30905672}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:16950109}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:16950109}. Endosome {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Present on sorting endosomes and recycling endosome tubules (PubMed:16950109). Tends to be enriched in PIP2-positive cell membrane domains (PubMed:16950109). During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis (PubMed:16950109). Identified in stage I to stage IV melanosomes (PubMed:17081065). Colocalizes with ACAP2 and RUSC2 at the membrane protrusions of HEK293T cells (PubMed:30905672). {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:30905672}.
Interaction partners:
- DENN domain-containing protein 1B
- DENN domain-containing protein 1A
- Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
- TBC1 domain family member 10A
- DENN domain-containing protein 1C
- AP-4 complex accessory subunit RUSC2
- MAP kinase-activating death domain protein
- Inositol polyphosphate 5-phosphatase OCRL
- TBC1 domain family member 10B
- Fascin
Sequence:
MARDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGEKVKLQIWDTAGQERFRTITSTYYRGTHGVIVVYDVTSAESFVNVKRWLHEINQNCDDVCRILVGNKNDDPERKVVETEDAYKFAGQMGIQLFETSAKENVNVEEMFNCITELVLRAKKDNLAKQQQQQQNDVVKLTKNSKRKKRCC
Protein: Fasciculation and elongation protein zeta-1 (Zygin I) (Zygin-1) (Q8K0X8)
Organism: Mus musculus (Mouse)
Function: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.
Interaction partners:
- Kinesin-1 heavy chain
- Synaptotagmin-1
- Disrupted in schizophrenia 1 homolog
- Short coiled-coil protein
- Kinesin heavy chain isoform 5A
- Protein unc-119 homolog A
- Syntabulin
Sequence:
MEAPLVSLDEEFEDIRPSCTEEPEEKPQCLYGTSPHHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTESLAPVKNQLQIQEEEETLRDEEVWDALTDNYIPSLSEDWRDPNIEALNGNSSDIEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPDPEEEEEVLEEEDGGEISSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDRVEGAIRDFSEELVHQLARRDELEFEKEVKNSFITVLIEVQNKQREQRELMKKRRKEKGLSLQSNRIEKGSQMPLKRFSMEGISNILQSGIRQTFGSSGADRQYLNTVIPYEKKSSPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT
Protein: Ferric iron-binding periplasmic protein HitA (Q9HVA8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Iron
- Probable permease of ABC iron transporter
- Probable ATP-binding component of ABC transporter
- Probable binding protein component of ABC iron transporter PA5217
- Probable outer membrane protein
- Tetratricopeptide repeat protein
Sequence:
MPVRLLNRFRHAALACLLGSLSLNAAADPVTLTLYNGQHAATGIAIAKAFQDKTGIQVKIRKGGDGQLASQITEEGARSPADVLYTEESPPLIRLASAGLLAKLEPETLALVEPEHAGGNGDWIGITARTRVLAYNPKKIDEKDLPKSLMDLSDPSWSGRFGFVPTSGAFLEQVAAVIKLKGQEEAEDWLTGLKAFGSIYTNNVTAMKAVENGEVDMALINNYYWYTLKKEKGELNSRLHYFGNQDPGALVTVSGAAVLKSSKHPREAQQFVAFMLSEEGQKAILSQSAEYPMRKGMQADPALKPFAELDPPKLTPADLGEASEALSLERDVGLN
Protein: ADP,ATP carrier protein 2, mitochondrial (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) (P40941)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14671022}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- UPF0235 protein At5g63440
- Mitochondrial phosphate carrier protein 2, mitochondrial
- At1g09850
- Probable cysteine protease RD21B
- Cysteine proteinase RD21A
- Probable cysteine protease RD21C
- Mitochondrial phosphate carrier protein 3, mitochondrial
- Small ribosomal subunit protein mS75
- Mitochondrial succinate-fumarate transporter 1
- Mitochondrial substrate carrier family protein
Sequence:
MVEQTQHPTILQKVSGQLLSSSVSQDIRGYASASKRPATYQKHAAYGNYSNAAFQYPLVAASQIATTTSPVFVQAPGEKGFTNFAIDFMMGGVSAAVSKTAAAPIERVKLLIQNQDEMLKAGRLTEPYKGIRDCFGRTIRDEGIGSLWRGNTANVIRYFPTQALNFAFKDYFKRLFNFKKDKDGYWKWFAGNLASGGAAGASSLLFVYSLDYARTRLANDSKSAKKGGGERQFNGLVDVYKKTLKSDGIAGLYRGFNISCAGIIVYRGLYFGLYDSVKPVLLTGDLQDSFFASFALGWLITNGAGLASYPIDTVRRRMMMTSGEAVKYKSSFDAFSQIVKKEGAKSLFKGAGANILRAVAGAGVLAGYDKLQLIVFGKKYGSGGA
Protein: Expressed protein (cDNA clone:J013036B10, full insert sequence) (Q75KP4)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MGEKVNPWCHWSNPPWTESSANNLHPPDVSLDNTNSVALPTYLNSDGYIYSGVAASMPSIAASVTDRPVSFSSRFVTTLVPSVGLSTAETLRKRPLVFFHNVNNTFTVGPLLSKGTLDTVPELQGSNETNVTDVGAQNTECMHENTEEIDALLCSDSDEGCLKVQELNNRVRKYPMQNDTMSVESVASAGASQPAKKRRLSSGTDRSVVDTASSARPDHSVDQKHLSHDDDAQSCCIGEVESDHQFALREGEEAEGDDGPDDRKRRRERIQETVAALRKIVPGGIAKDATAVLDEAICYLKYLKLKVKTLGAVSL
Protein: Small ribosomal subunit protein bS18 (30S ribosomal protein S18) (P66459)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Interaction partners:
- Small ribosomal subunit protein bS6
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein bL9
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein uS2
- Bifunctional DNA-directed RNA polymerase subunit beta-beta'
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS15
Sequence:
MERKRYSKRYCKYTEAKISFIDYKDLDMLKHTLSERYKIMPRRLTGNSKKWQERVEVAIKRARHMALIPYIVDRKKVVDSPFKQH
Protein: Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Bridging integrator 1) (SH3 domain-containing protein 9) (O08539)
Organism: Mus musculus (Mouse)
Function: Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O00499}. Cytoplasm {ECO:0000269|PubMed:12668730}. Endosome {ECO:0000269|PubMed:12668730}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08839}.
Interaction partners:
- Myc proto-oncogene protein
- Ras and Rab interactor 3
- Dynamin-2
- Dynamin-1
- Synaptojanin-1
- Amphiphysin
- Clathrin heavy chain 1
- Synaptojanin-2
- Clusterin
- Intersectin-1
Sequence:
MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLSECLQEVYEPEWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVSLEKQHGSNTFTVKAQPSDNAPEKGNKSPSPPPDGSPAATPEIRVNHEPEPASGASPGATIPKSPSQLRKGPPVPPPPKHTPSKEMKQEQILSLFDDAFVPEISVTTPSQFEAPGPFSEQASLLDLDFEPLPPVASPVKAPTPSGQSIPWDLWEPTESQAGILPSGEPSSAEGSFAVAWPSQTAEPGPAQPAEASEVVGGAQEPGETAASEATSSSLPAVVVETFSATVNGAVEGSAGTGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERVQ
Protein: Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4) (P15731)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Mediates ubiquitination of PEX5.
Interaction partners:
- Ubiquitin-activating enzyme E1 1
- General negative regulator of transcription subunit 4
- Polyubiquitin
- Ubiquitin-conjugating enzyme E2-16 kDa
- E3 ubiquitin-protein ligase RSP5
- Anaphase-promoting complex subunit 11
- Ubiquitin fusion degradation protein 4
- Ubiquitin-conjugating enzyme E2 1
- E4 ubiquitin-protein ligase UFD2
- E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8
Sequence:
MSSSKRIAKELSDLERDPPTSCSAGPVGDDLYHWQASIMGPADSPYAGGVFFLSIHFPTDYPFKPPKISFTTKIYHPNINANGNICLDILKDQWSPALTLSKVLLSICSLLTDANPDDPLVPEIAHIYKTDRPKYEATAREWTKKYAV
Protein: Cell division protein FtsZ (O08398)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00909}. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane. {ECO:0000255|HAMAP-Rule:MF_00909}.
Interaction partners:
- Cell division protein FtsA, putative
- Cell division protein FtsA, putative
- Probable septum site-determining protein MinC
- Protein translocase subunit SecA
- DNA gyrase subunit B
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- General secretion pathway protein E
- Hypothetical protein
- Rod shape-determining protein RodA
- Probable branched-chain-amino-acid aminotransferase
Sequence:
MGFDLDVEKKKENRNIPQANNLKIKVIGVGGAGNNAINRMIEIGIHGVEFVAVNTDLQVLEASNADVKIQIGENITRGLGAGGRPEIGEQAALESEEKIREVLQDTHMVFITAGFGGGTGTGASPVIAKIAKEMGILTVAIVTTPFYFEGPERLKKAIEGLKKLRKHVDTLIKISNNKLMEELPRDVKIKDAFLKADETLHQGVKGISELITKRGYINLDFADIESVMKDAGAAILGIGVGKGEHRAREAAKKAMESKLIEHPVENASSIVFNITAPSNIRMEEVHEAAMIIRQNSSEDADVKFGLIFDDEVPDDEIRVIFIATRFPDEDKILFPEGDIPAIYRYGLEGLL
Protein: Cytoplasmic 60S subunit biogenesis factor REH1 (REI1-homolog 1) (pre-60S factor REH1) (Q06709)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. May act redundantly with REI1 to directly promote a stabilizing structural rearrangement in cytoplasmic 60S subunit maturation independent on the REI1-specific ARX1 recycling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 60S ribosomal export protein NMD3
- Eukaryotic translation initiation factor 6
- Large subunit GTPase 1
- Large ribosomal subunit protein uL22A
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein eL24A
- Large ribosomal subunit protein uL29A
- Large ribosomal subunit protein uL4A
- Ribosome biogenesis protein RLP24
- Large ribosomal subunit protein eL29
Sequence:
MSSTFFTCNCCVIQFKTSDLQRYHMKTEWHRYNLKRRIANLPPIGAEQFAEKLQISEKEQAENQVDEFGFPVLKPVMNQSNALPQKQKKPIKSKRGRKVGTNLLKRKDRDIAKEKQNRSVSPSGSISSQLSNLTVGTENTNTDYGEDTVSEYGFTSDSNYEYATSDEELDIADKPSDKENEKITITECIYCGKDNKEVERNVKHMFSEHGLFIPERSYLIDLNGLLEFLIKMIVIDHNCLCCNFHGSGLESIRAHMASKRHCRLPYETKEERQLFAPFYDFTYDDHSISKNLQNDRAITSKLSSVYGAKNDEEDGEVDITLVSSENDINANYTTVSIDESGLELTLPTGARLGHRAGQRYYRQNLPSQPNPNESRRTITAADRRMVSGVTEKQYKKGMKKMQQLEKNAINTQIRREIKRVNFQTHYRDELLQ
Protein: Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase) (P49897)
Organism: Rattus norvegicus (Rat)
Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P55073}; Single-pass type II membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:P55073}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MPRQAASRLVVGEGEGPPGASGPAATMLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGFQSQRILDYAQGTRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPRRL
Protein: UDP-N-acetylglucosamine pyrophosphorylase 1 (D3ZF39)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Phosphoacetylglucosamine mutase
- Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
- UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
- UDP-glucose 4-epimerase
- Glucosamine 6-phosphate N-acetyltransferase.
- Glutamine--fructose-6-phosphate aminotransferase 1
- Galactose-1-phosphate uridylyltransferase
- N-acetyl-D-glucosamine kinase
- Interleukin-11 receptor subunit alpha
- Phosphoglucomutase-1
Sequence:
MNVNDLRQRLSAAGQQHLLQFWSELSEAQQGELYMELQAMNFEELNSFFQKAVGEFDRSSHQEKVDARMEPVPRQVLGSATRDQDQLQAWESEGLSQISQNKVAVLLLAGGQGTRLGVTYPKGMYDVGLPSHKTLFQIQAERILKLQQLAEKQYGNKCTIPWYIMTSGRTMESTKEFFTKHKFFGLKKENVVFFQQGMLPAMSFDGKVILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLKDVVNVYEPQLQHHVAQKKIPYVDSQGHLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLEGYVADKDFHAPLIIDENGVHELVKNGI
Protein: CCAAT/enhancer-binding protein alpha (C/EBP alpha) (P53566)
Organism: Mus musculus (Mouse)
Function: Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung. Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage. To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex. In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites.
Subcellular location: Nucleus {ECO:0000269|PubMed:36228616, ECO:0000269|PubMed:8415748}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleolus {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P49715}.
Interaction partners:
- Transcription factor PU.1
- Runt-related transcription factor 1
- Cyclin-dependent kinase 4
- Peroxisome proliferator-activated receptor gamma
- Cyclin-dependent kinase 2
- Transcription factor E2F1
- Forkhead box protein O1
- CCAAT/enhancer-binding protein beta
- Receptor-type tyrosine-protein kinase FLT3
- Protein CBFA2T1
Sequence:
MESADFYEVEPRPPMSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAVMSAGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQPPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHAAPALGAAGLPGPGSALKGLAGAHPDLRTGGGGGGSGAGAGKAKKSVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA