wanglab/gogpt-training-data huggingface dataset:
Protein: N-acetylneuraminate (7)9-O-acetyltransferase (EC 2.3.1.45) (CAS1 domain-containing protein 1) (CAS1 protein) (Cas1p) (Sialate O-acetyltransferase) (SOAT) (Q7TN73)
Organism: Mus musculus (Mouse)
Function: O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids. Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96PB1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96PB1}.
Interaction partners:
- Sialate O-acetylesterase
- Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
Sequence:
MAALAYNLGKREINHYFSVRSAKVLALVAVLLLAACHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKTCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKAASVKVDFLWHPEVNGSMKQCIKVWTEDSVLKPHVIVAGAATWSIKIHNGSEEALAQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRTSKSNVKMFSVSKLIAQETIMESLDGLHLPESSRETSAMILMNVYCNKVVKPVDGSCCQPRPPLTLIQKLAACFFTLSIIGYFIFYVIHRNAHRKNKPCTDLESGEEKKNIINTPVSSLEILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFGIHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQITQKKANGNFFWYLGLLLKLGLLLLCIWFLAYSQGAFEKIFSLWPLSKCFELEGSVYEWWFRWRLDRYVVFHGVLFAFIYLALQRRQILSEGKGEPLFSNKISNFLLFVSVVSFLTYSIWASSCKNKAECNELHPSVSVVQIVAFILIRNIPGYARSIYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPTLNIIVSTFIFVCVAHEISQITTDLAQVVIPKDNPSLFRRLACTIAFFGGVLILSSIQDKSRL
Protein: Zinc transporter 35C, isoform B (Q8IP48)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLANWQTARKSSEMNDARLYRNAATSLDKSRLEMLHEYVRDHCHRARSEGVDVKARRKLIIASILCLVFMIAEIVGGVLSNSLAIATDAAHLLTDFASFMISLFAIWIAGRPSTQRMSFGWYRAEVIGAMASVFMIWVITGILVWLAIGRLISGDYEVNAKIMLITSGLAILVNVIMGVQLQHGHSHGLGGGHGHSHGGSKNASHVQATSTPCSDSPSQRIEGGVAYAPEDAELPGGGLPTFSYQNTKLVDPTLDLEIAAVLAETAPGSHHHGGPVGREAVNMNVRAALIHVIGDVIQSVGVFVAAGVIYFWPEYSIVDPICTFVFSIIVLFTTFTIMKDALLVLMEGTPNYMHYAEVLQIFQGIEGVERVHNLRIWALSINKVALSAHLAIAENANPKRILDAATSAVHLRYNFFETTIQIEDYTAQMESCLQCNVPEK
Protein: Chaperone protein DnaK (75 kDa membrane protein) (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (P27542)
Organism: Chlamydia pneumoniae (Chlamydophila pneumoniae)
Function: Acts as a chaperone.
Interaction partners:
- Protein GrpE
- Chaperone protein DnaJ
- Heat-inducible transcription repressor HrcA
- Chaperonin GroEL 1
- Co-chaperonin GroES
- Nitrogen fixation protein NifU
- Chaperone protein ClpB
- Probable ATP-dependent Clp protease ATP-binding subunit
- Chaperonin GroEL 2
- 60 kDa chaperonin
Sequence:
MSEHKKSSKIIGIDLGTTNSCVSVMEGGQAKVITSSEGTRTTPSIVAFKGNEKLVGIPAKRQAVTNPEKTLGSTKRFIGRKYSEVASEIQTVPYTVTSGSKGDAVFEVDGKQYTPEEIGAQILMKMKETAEAYLGETVTEAVITVPAYFNDSQRASTKDAGRIAGLDVKRIIPEPTAAALAYGIDKVGDKKIAVFDLGGGTFDISILEIGDGVFEVLSTNGDTLLGGDDFDEVIIKWMIEEFKKQEGIDLSKDNMALQRLKDAAEKAKIELSGVSSTEINQPFITMDAQGPKHLALTLTRAQFEKLAASLIERTKSPCIKALSDAKLSAKDIDDVLLVGGMSRMPAVQETVKELFGKEPNKGVNPDEVVAIGAAIQGGVLGGEVKDVLLLDVIPLSLGIETLGGVMTTLVERNTTIPTQKKQIFSTAADNQPAVTIVVLQGERPMAKDNKEIGRFDLTDIPPAPRGHPQIEVSFDIDANGIFHVSAKDVASGKEQKIRIEASSGLQEDEIQRMVRDAEINKEEDKKRREASDAKNEADSMIFRAEKAIKDYKEQIPETLVKEIEERIENVRNALKDDAPIEKIKEVTEDLSKHMQKIGESMQSQSASAAASSAANAKGGPNINTEDLKKHSFSTKPPSNNGSSEDHIEEADVEIIDNDDK
Protein: Uncharacterized protein (Q38DK6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Enoyl-CoA hydratase/isomerase domain-containing protein
- Small ribosomal subunit protein mS41
- Uncharacterized protein
- Pentacotripeptide-repeat region of PRORP domain-containing protein
- Uncharacterized protein
- Ribosomal protein S9
- LysM domain-containing protein
- Opioid growth factor receptor
Sequence:
MMRSSSFCRRQIRPYYNLPSKSEHGRKMTGFLTPYRHWMWKQNELWRNVHEAQFEHLRRVYKRQWLESFRVNADEYIYKYNITKAAQLAQWECEMKEQEKKRIEARQMMDGRQALKKKHLDLLREFHERQFFFWYERASERLQNMNLINYVPHAQLREHIDKELDKYVAGKNEPYPLNFVGQMPFLEDGDGNIVEVPESLLSNHMAEHPDSTAKPHEPHTSSSISEAAAFEERMLRAMVSAKEEDLKEWLGDDSRALSETIDDISREEEEREADIRVARSMEETDAEREVSRRAYIERGKTGSRSIFRPPTVSEGAGGTPSAPAGDANTPMRRRKKGKLDRVHALQAHQDELLAKLSSQGLKEGVDASSVPERGKIVQSRGRIRDKAVIPTHEVLMQKPELAAGSTPGARIQTKDMVDKMYHRGKYKKSGSGDKSDGEDL
Protein: PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) (P54277)
Organism: Homo sapiens (Human)
Function: Probably involved in the repair of mismatches in DNA.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- DNA mismatch repair protein Msh6
- DNA mismatch repair protein Mlh1
- DNA mismatch repair protein Msh3
- DNA mismatch repair protein Msh2
- Mismatch repair endonuclease PMS2
- DNA mismatch repair protein Mlh3
- Fanconi-associated nuclease 1
- Exonuclease 1
- MutS protein homolog 4
- DNA polymerase delta catalytic subunit
Sequence:
MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEGIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLTYLPETT
Protein: Histamine-gated chloride channel subunit (A1KYB5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVFQIIILVICTICMKHYAKGEFQQSLAITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKNHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVFYEYL
Protein: Quinidine resistance protein 1 (P40475)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11302822}; Multi-pass membrane protein {ECO:0000269|PubMed:11302822}.
Interaction partners:
- Polyamine transporter 1
- Protein HOL1
- Pleiotropic ABC efflux transporter of multiple drugs
Sequence:
MTKQQTSVMRNASIAKEEREGSDNNNVDRSSSDAISDNDAERSNSHSEIDNESNFDMVPYSRFSHKQKMLLVVQCAFTGFFSTVAGSIYYPVLTIIERKFNITEELANVTIVVYFIFQGVAPSIMGGLADTFGRRPIVLWAILAYFCACIGLACAHNYAQILALRCLQAAGISPVIAINSGIMGDVTTKVERGGYVGLVAGFQVVGTAFGALIGAGLSSKWGWRAIFWFLAIGSGICLVFSTLLMPETKRTLVGNGSVTPRSFLNRSLILHVGSVKKTLHLDDPDPETLEPRTSVDFLAPLKILHIREIDILLSIAGLQFSTWTTHQTALTIVLSKKYNLSVAKIGLCFLPAGISTLTSIISAGRYLNWSYRTRKVKYNRWIKEQELQLMEKYKGDKNKVAELIHSNSHYAFNLVEARLHPAFVTLLLSSIGFTAFGWCISVKTPLAAVLCTSAFASLFSNCILTFSTTLIVDLFPSKASTATGCLNLFRCLLSAIFIAALTKMVEKMRYGGVFTFLSAITSSSSLLLFYLLKNGKQLSFDRIRANDKSAGRSVGKNSEKVST
Protein: Probable carboxylesterase 12 (AtCXE12) (EC 3.1.1.1) (Q9SMN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carboxylesterase acting on esters with varying acyl chain length.
Interaction partners:
- Alpha/beta-Hydrolases superfamily protein
- Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL1
- Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL2
- Prolyl endopeptidase
- Acylamino-acid-releasing enzyme
- Methylesterase 2
- Methylesterase 3
- Probable carboxylesterase SOBER1-like
- Alpha/beta-Hydrolases superfamily protein
- Serine carboxypeptidase-like 11
Sequence:
MDSEIAVDCSPLLKIYKSGRIERLMGEATVPPSSEPQNGVVSKDVVYSADNNLSVRIYLPEKAAAETDSKLPLLVYFHGGGFIIETAFSPTYHTFLTTSVSASNCVAVSVDYRRAPEHPISVPFDDSWTALKWVFTHITGSGQEDWLNKHADFSRVFLSGDSAGANIVHHMAMRAAKEKLSPGLNDTGISGIILLHPYFWSKTPIDEKDTKDETLRMKIEAFWMMASPNSKDGTDDPLLNVVQSESVDLSGLGCGKVLVMVAEKDALVRQGWGYAAKLEKSGWKGEVEVVESEGEDHVFHLLKPECDNAIEVMHKFSGFIKGGN
Protein: Ferredoxin-thioredoxin reductase subunit A2, chloroplastic (FTR-A2) (Ferredoxin-thioredoxin reductase, variable chain FTRA2) (FTR-V 2) (Q8LBP6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Variable subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MTNSYALSPAIIAAVRPPASQDYLVAASLSGRKSINSSSSSIFVPISLSTSYGRSKCAFSISRKNPKSTIRCDIAVKSAASVDADADLSSSTSLETEEDEKAKEKIGARVRVTVPLKVYHVVRVPEVELMGMEGFIKDYVVLWKGKKISANLPFKVQFVKEIEGRGPVKFFTHLKEDEFELIDP
Protein: DNFAT (LD28881p) (NFAT nuclear factor, isoform D) (Q9GU53)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLLKFTKTSGAGPSAVPLLTTAPATVTSSASMQATTTSYAARGTGMRMTMSTNSTMSARIHRKGFRIPSKRQPGKGLPGKLHTITRTGPGKMVPGKRIPQRPHPPPCDNSNDSGLGFDQHTELRSSAGAGGVTDPAANGGSGSNSGQRSSLLVNSALTNTVAAAAAAAAAAVASNTLQQHQQHHQQQQQQQQQQQQQQQQQQQQQQQQQHSPQQHLIRAIPVSRFISARNVTRVANKRQPTTPLNSVASSNDGQVQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGYDKVAVLQVFIGTDIGRVAPHMFYQACKVAGKNSTQCNEKKVDGTMVIEIDFKPETDMTITCDCVGILKERNVDVEHRFPEHLAQKNKKKSTRCRMVFRTQLTRDDGTTETLQVCSNPIICTQPPGVPEICKKSLNSCPVDGGLELFIIGKNFLKDTHVVFQETYDSVNGDDPATEIAVRQQLIGGTAALWEQSVLPDKEYLHQTHLICTVPPYLHQNILKPVQVQVSIVSSGKKSEPHTFTYTAKGQYTTLAAASTLSNTIHAQDVSGFMDTTSASNASGSSGWSAAGGSGNNTSTGDNVEAKHEIDSGMMPPPITTQIPMGVRRSSLPSVTPMITDQQLVHLNAVAASAEALKTELDDSNSHSPLTGESTPDSPNAALQYHRFARKPSLDTIMYDQSNSLPGFPTVVAPATAAAVAAAVDIDPTAVAVAVELAVKNEIVKHVVQQHQQMQEQMHEQQQQQQQQQQQQQQQQQQQPQQQQQQQVHKFIDELTKSTSVVSSNGTTEPALFTTSAVIDHALTDILQAKVGIAPPNVVLERSLSLSSTNSSSSMSGSESSPNSSPLTQDIILNSEPAAALAGAAALGGPAPVDVTGGLSTDIIMNPAVSPSTILCSANGAATAVVPNILAPHQVTMANSILNDIAMQPEPTQQDAAVAALALSNIMMSPPTAASGVGVGDTLPPTPATMQPEVAATATSTAVSNMIIKAAADFITTQEQEQHHYHHHGRIHSHSPQAAVGVSGNPAETASDPLVDLLLNHSNTPETAAAAAAAVAVEAANFQSMNHSHHSHHGHHGHSHGHGHSRVTGHVSGHVTSHHRGHHLPVVPPTPQESLIVALASENALQKSVATAAVTTNGAVMTQQASAPNTAGSILPAAVGAVAAAAAVAVQPPIPQELTTMSDQDLISYINPSTFDQL
Protein: At1g58270/F19C14_8 (F19C14.11 protein) (TRAF-like family protein) (ZW9 protein) (Q9SLV3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- TCP-1/cpn60 chaperonin family protein
- Jacalin-related lectin 32
- ATP synthase subunit O, mitochondrial
- Myrosinase 5
- Universal stress protein PHOS32
- ATP synthase subunit beta-1, mitochondrial
- Probable mitochondrial-processing peptidase subunit beta, mitochondrial
- Dirigent protein 6
Sequence:
MYSEEKKSRNYGSIFVYCFFCFVLIVEVARFAKPYINLQNLIETEAVVEEGFMAVGNSGNLPCGSSKPSSASVRAHDEQKLSQAVTTDTRTRPPNSYCVKFQSFVTMAKQVKENGGKYESRPFSVGGYNWTLLIYPVIYIPTDSGGYVSIYVRVDNSSLITNPKDVYAEITFLAYKSSTDKYQISQETEAQRFHLFKQQWGLLQFLPIYYFENPAYGYFFEGESVVFGVDINIVKPFENWEVFSNEQNIRDPIFEWRLTKFSTRFLDSYTSDSFSSGGRNWALKVYPNGVGNATGNSLSLYLLSDQSNDKGYVEAKLRVIDQIQSNNFEKKVAAWPNATENGWGFDRFLSFADIKNTSKGFLVNDTLKLEVQILSFSKTDYYSHQSSLNVLTGDST
Protein: Polyadenylate-binding protein-interacting protein 12 (PABP-interacting protein 12) (Poly(A)-binding protein-interacting protein 12) (PAM2-containing protein CID12) (Protein CTC-INTERACTING DOMAIN 12) (RNA-binding protein 37) (AtRBP37) (Q9S7N9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds nucleotic acids in vitro.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Polyadenylate-binding protein-interacting protein 2
- Polyadenylate-binding protein-interacting protein 3
- Ribosome assembly factor mrt4
- Polyadenylate-binding protein-interacting protein 6
- Polyadenylate-binding protein-interacting protein 5
- Polyadenylate-binding protein-interacting protein 7
- Polyadenylate-binding protein-interacting protein 4
- Protein EARLY RESPONSIVE TO DEHYDRATION 15
- Polyadenylate-binding protein 6
- Protein RDM16
Sequence:
MAVIESVGANTTVEAGGLISPSPPSSVTSQESGASSNNDHGGNGIHDEIGVHVARSDGGESFKRDMRELHELLSKLNPMAKEFIPPSLTKPVVNGFNGGFFAVNNGFVAAGNFPVNEDGSFRRKKSFGQQGKRRMNPRTSLAQREEIIRRTVYVSDIDQQVTEEQLAGLFIGFGQVVDCRICGDPNSVLRFAFIEFTDEVGARTALNLSGTMLGFYPVKVMPSKTAIAPVNPTFLPRTEDEREMCARTIYCTNIDKKLTQTDIKLFFESVCGEVYRLRLLGDYHHPTRIGFVEFVMAESAIAALNCSGVLLGSLPIRVSPSKTPVRSRAIPRHQMH
Protein: Nucleolar complex protein 2 (P39744)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the intranuclear transport of ribosomal precursors.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11371346}.
Interaction partners:
- Nuclear GTP-binding protein NUG1
- Ribosomal RNA-processing protein 1
- Ribosome production factor 1
- 60S ribosome subunit biogenesis protein NIP7
- ATP-dependent RNA helicase DRS1
- 27S pre-rRNA
- Nucleolar GTP-binding protein 1
- Ribosome biogenesis protein YTM1
- Ribosome biogenesis protein RLP24
- rRNA biogenesis protein RRP5
Sequence:
MGKVSKSTKKFQSKHLKHTLDQRRKEKIQKKRIQGRRGNKTDQEKADAAGTREQQQLKKSAKEEVFKDMSVETFFEKGIEIPKENKKLKKKTTKEQSDEDSSSSEEEEDMGQSMAKLAEKDPEFYKYLEENDKDLLDFAGTNPLDGIDSQDEGEDAERNSNIEEKSEQMELEKEKIELSLKLVRKWKKQLHDSPSLKLLRNIISAFKVAVNLNKEENIEDYKYAITDEKAFHELMFMVLKDVPQAIQKMAPYKIVKGARTLPNGGNVSRVSSIVKSHAGSLLILLNDITNTETAALVLHSVNELMPYLLSYRRILKELIKSIVGVWSTTRELETQIASFAFLINTTKEFKKSMLETTLKTTYSTFIKSCRKTNMRSMPLINFQKNSAAELFGIDEVLGYQVGFEYIRQLAIHLRNTMNATTKKSSKINSAEAYKIVYNWQFCHSLDFWSRVLSFACQPEKENGSESPLRQLIYPLVQVTLGVIRLIPTPQFFPLRFYLIKSLIRLSQNSGVFIPIYPLLSEILTSTAFTKAPKKSPNLAAFDFEHNIKCTQAYLNTKIYQEGLSEQFVDLLGDYFALYCKNIAFPELVTPVIISLRRYIKTSTNVKLNKRLSTVVEKLNQNSTFIQEKRSDVEFGPTNKSEVSRFLNDVAWNKTPLGSYVAVQREVKEEKARLMRESMEEQDKERETEEAKLLNSLESDDDNEDVEMSDA
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (Q9I9P1)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
Sequence:
HVIYCRVWRPDLHSHHELRAMEMCEYAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNYIPETPPPGYLSEDGETSDHQMNPSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGLTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIE
Protein: E3 ubiquitin-protein ligase ubr3 (EC 2.3.2.27) (E3 ubiquitin-protein transferase ubr3) (F1QJX5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation (By similarity). Positively regulates hedgehog/shh-signaling pathways that function in eye development, neuronal specification and somite development. Activation of shh up-regulates transcription of ubr3, which in turn promotes hedgehog/shh signaling possibly by controlling negative regulators such as Kif7.
Interaction partners:
- Ubiquitin protein ligase E3 component n-recognin 7.
- E3 ubiquitin-protein ligase
Sequence:
MMAASLLRRDKKSTAAHLKADLKRTDNSSGLRQLQELLDSVLNPERGSDPEALDWCKWLLAGGDGFDEFCRTVRSYDNATLCGLVWTANFVAYRCRTCGISPCMSLCAECFNNGDHTGHDFNMFRSQAGGACDCGDGNVMRESGFCNRHRLKTGENVPSVPRDLLLMSEMVLPRFIITIIQYLRDGYTEPESAADRDLQKVLQQLDPHISFLEELTKMGGAMRTVLTKILTDQQTFKELSMGQEDNVYAKKNYEKYLSALKSSGLVSVEEKGAAGGAGDGTSDAAAGAGALSLLGATATASLDDSSKEEDQDGLQGVGQRKRVKLSSSTKDPSIMDTLKHKCFLEELLFWTIKYEFPQKMVTFLLNMLPDQDYKITFTKTFVQHYAFIMKTLMKSHESDTMSNRIVHISVQLFSNEELARHVTEECQLLDIMVTVLLYMMESCLIKSELQDEENNRHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHSLLLLWMSFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLTHCKVKETQDYTKTVVRYCLETLQMWFDAIGFVDEPSLNQLTFHLPLHRYYAMFLSKGVKCQGLDLDSLLPDQEMLMKIMVHPLQIQASLSEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLLTMASQHQNAVLDSEQERPMLEGALTFLVILCSLRIHLGMSDDEILRAEMVSQLCMNDRTHSSLLDLIPENPNPKSGVVPGSCSFEEMLSGVADFKAPVFEPGGSMQQGMYTPKAEVWEKEFDPIMVILRTVYRRDVQSAMDRYSAFLKQSGVHTGNPWPPYKERTPLHPCYKGLVRLLHCKTLHIVIFTLLYKIWMDHQNMSEHVLCMVLYLIELGLDNQVQDDKVEEEPCIEEHCHDSWFPGTSLLSNLHHVINFVRVRVPETAPEVERKRERERERETPPSTSSESATFGQNLREAQVFSLVAERRRKFQEIINRSNHEASQAVRPKSSASRWLPPGTPPQLVTEILEIRESMLSLLVKLHQKLSAKQNSLSLSWLAEVDPAHHAHGDGLTAIERILAKASARSRHSKRCLQEICGKVCPPIPPKKISPGDKKSMDKEERRQRARERQQKLLAEFASRQKSFMETAMDVESPEADAVMDVSSEESLDSEVLYDCVICGQSGPSTEDRPTGLVVLLQASSVLGHRCRSDMPKRLPTTDEEHIYPEDTCGATHDVRLSLMQRYFKDSSCLQSVSIGWDGGVYVQTCGHTLHIDCHKSYMESLRNDQVLQGISVDKGEFTCPLCRQFANSVLPCRPGRGMETGAWHAPSTKSMSTLVKEVEDLQEQLGIFPVRASIKQRDPILIESNLSKEMESVIKDIKNTTQKKYMDYGKNPGSPDNDFLFMYSVARTNLELELVHRGGNLCSGGASAAAKRSCLNQLFHVLAMHMRLYSIDSAYNPWTRLTLSTQSRENEYCDEERPEVPMLFRDVPSLLIIFILTMPQPLRKEHFTCVVKVLYSLQFTQALAALSIRFSREERLAWSNTGAAKKNLPNSDKSWESLLGHMISELTKAKDVYDTNSEETSALSSSVWSPQSIEFRLQQFCLPFLRLSCLLQHHLYGDSLPGCLVEEEFSLLTRCLGLAASVQCSGSMSSAACLEWNISAFDLISQWCSEVVALSDTPSQQSASLLGQDPQWAAPRLLQLPDNYNTIFQYYHRKSCSSCGKTPKDPALCLVCGAFVCLKGHCCKQQGVCECVLHSQHCGAATGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYLCEERYRVLEQQWVAHTFDHINKRWGPHYNGL
Protein: RanBD1 domain-containing protein C584.03c (O94589)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MDELLNVASHAATFATNFALKHSISFAGKLAVQQVSSYIKRASADDQSELESVKTQLLEMIRVVTPAIELIEIMSVGENENFKSTKQLVDSLHADIEQFTKHVLSAAHSEFPPSSEKETLQKNVDTSILREMKTLLLKINDAVPLLNLSITTSGASISSSLPKSTSFSQLLRANSYIYRANVAFTGNEPLQVGPTFFLRTYKIIDNHAKSGYISNDLVMWKEEMPVCIAKMFRMPPQRLKSKDTVLAYALSLKQSFDDDRYHDEDETPVTKTISLNDVRTLFFSLSGKLLRLDDVQTPVLLLKYADDETEYSSNTAPSNWIALEALPLVSIPNESLDESDELAESLSDSEAARLQLLGIKKQESVAKKKSSFPSTIKDQPNLTLLEYLIRLCALESTTQESVLQLPDEQIALYLKDYQGRERPRDPASYNALENRSELSASPGSVSSSRHSGIFATPTFLSPWNIKNIPLVTPEVSTRQTKNVDEEDSALLMASPSVRKSNLLPQEDLISKDSVIKLKENPSVIPHSEPESSSKVINCQAKLNVEKEKKNP
Protein: SKI-like proto-oncogene (D3ZWL1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Mothers against decapentaplegic homolog 4
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 3
- Nuclear receptor corepressor 2
- RING-type E3 ubiquitin transferase
- E3 ubiquitin-protein ligase
- Mothers against decapentaplegic homolog 7
- TGFB-induced factor homeobox 1
Sequence:
MENLQSNFSLVQGSNKKLSGMEDDGSPPVKKMMTDIHANGKTLTQVKKEHLDDYGDASVEPDGEHAKRNCPSLPETLNLNPSLKHTLAQFHLSSQSSLGGPAAFSARYSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILPAKSSWAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRNGKRIQSKTDTPSGMELPPWYPVIKQEGDHGPQTHSFLHPSYYLYMCDKVVAPNVSLASAASQSKAVTKAETSKSISKQSEKPHDSSKRQKTVSYPDVSLEEQEKMDLKTSRELYSCLDSSVSNNSTSKKKCESTICDLVRDTDKQGSGASSPLVVRDVTCEDDKGKIVEDVMRTYVRQQEKLSSILQKKQQLQMEVEMLSSSKAMKELTEEQQNLQKELESLQNEHAQRMEEFYIEQRDLEKKLEQVMKQKCTCDSNVEKDKEAEYAAQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQIVKSSKTAKE
Protein: Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide] (P38845)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cruciform DNA-binding protein which exerts an enhancing effect on the cleavage of cruciform DNA (X-DNA) by endonuclease VII from bacteriophage T4.
Interaction partners:
- Saccharopepsin
- Protein SDS24
- Protein SDS23
- 5'-AMP-activated protein kinase subunit gamma
- Maintenance of telomere capping protein 1
Sequence:
MSSELMFNYTFSWPAGPKDVILTGTFDDWRGTLPLVKTAKGNFEITMPVKLANKDDTFQFKFIVDGVWCVSDSYKKEHVSEGIENNFLQITDLVETQEVAGASRIPEAGGLLCGKPPRSAGPPSTSNRKKNKRNNKKRRSKLKKKSTKNNKKSNESLDDNEEEDGVTGTTTEDVTGTSREETPLAEPTNVSKEAPGNFHILPIDQSADTTQSNGIIGGPGPVLVPNPGEIKEFTEIRDVDARELNERLNKKEEVPEPVAGPIVESSVTEKSPALPQADDPIVETKEVAHNVQELTPQVEAVTPLINEPEPLPTPEAQISIPESSKVEPVEGSLQSKLVEKRESTEGVLDGSKKVENKAKKDEEVFTLDPIVNKAPKLPLTDEQTAEGRKSPAVSEEKEKKKKQEKGSKEVKRSETSKEKKPSAKEVKKQTVKAPKKQTASPLSSSTEEPKKKKTGFFGKLKKLFK
Protein: Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] (P32394)
Organism: Sus scrofa (Pig)
Function: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P09601}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}.
Interaction partners:
- Kelch-like ECH-associated protein 1
- Flavodoxin_2 domain-containing protein.
- NFE2 like bZIP transcription factor 2
- Glutathione peroxidase 1
- NADPH--cytochrome P450 reductase
- Glutamate--cysteine ligase
- Caspase-3
- Heme oxygenase
- Biliverdin reductase A
- Glutamate--cysteine ligase regulatory subunit
Sequence:
MEHSQPNSMPQDLSEALKEATKEVHVQAENAEFMKNFQKGEVTREGFKLVMASLYHIYDALEEEIEHNKENPVYTPLYFPEELHRRAALEQDMAFWYGPRWQEAIPYTQATKRYVRRLQQVGRFEPELLVAHAYTRYMGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNVANATKFKQLYRSRMNTLEMTPEVKQRVLEEAKTAFLLNIQLFEEVQELLTQDTKDQRPSQASDIRKRAGSRVQDSTPVTTPRGKPQLSVLSQVPLIRWVLTLSFLVATVAMGLYAM
Protein: Parathyroid hormone-like hormone b (Parathyroid hormone-like hormone b precursor) (Parathyroid hormone-related peptide 2) (Q1L5E7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Parathyroid hormone/parathyroid hormone-related peptide receptor
- Parathyroid hormone 1 receptor b
- Indian hedgehog B protein
- Parathyroid hormone 2 receptor
- Tuberoinfundibular peptide of 39 residues
- Importin subunit beta-1
- Parathyroid hormone 1a.
Sequence:
MLRHWGFAVFLLTIPIPIQSRATNAPSSRQRRSVGHAQMMHDRSRSLHDRKRRMWLQDLLEQVHTAQVWDSPNQSEGSVQTLSWPRPKHTGSTKNIPLGYQMESIGTRDDLPQETSKSLTYEEQPLKAAMKRKSKMCLGRWRERDRRRDRACAFQMQMHMRE
Protein: NADPH oxidase 3 (EC 1.6.3.-) (Q672K1)
Organism: Rattus norvegicus (Rat)
Function: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q672J9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome b-245 light chain
- NADPH oxidase 2
- NADPH oxidase 1
- NADPH oxidase 4
- NADPH oxidase organizer 1
- Neutrophil cytosolic factor 1
- Dual oxidase 1
- NADPH oxidase activator 1
- Neutrophil cytosol factor 4
- Dual oxidase 2
Sequence:
MPTCWILNESVSFVVALLWLAINIYLFIDTFCWYAEEESFFYTRVILGSALAWARASAVCLNFNCMLILLPVSRNFVSLVRGTSVCCRGPWRRQLDKNLKFHKLVAYGIAVNSVIHIVAHLFNLERYHLGQAKDAEGLLAALSKLGNAPNESYLNPVRTLYTGTTTQLLMTVSGITGLVISLALILIMTSSTEFIRQSSYELFWYTHHIFIFLFISLAIHGGGRIIRGQTPESLRLHNVTFCRDHFDEWQEAASCPVPQFSGKEPSAWKWTLGPVVLYACEIIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSISPLEWHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFGAEGQAPSELCSMPRLAVDGPFGGSLADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQSLPGLSKVYFYWICRDAAAFEWFADLLLSLETQMSEQGKAHLLSYHIYLTGWDEYQAIHIALHWDESLDVITGLKQKTFYGRPNWNEEFKQIAYNHPSSSIGVFFCGPKAMSKTLQKMCRLYSSSDPRGVHFYYNKENF