wanglab/gogpt-training-data huggingface dataset:
Protein: Contactin-2 (Axonal glycoprotein TAG-1) (Axonin-1) (Transient axonal glycoprotein 1) (TAX-1) (P22063)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region (By similarity).
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons.
Interaction partners:
- Tax1-binding protein 1 homolog
- Potassium voltage-gated channel subfamily A member 1
- Neural cell adhesion molecule L1
- Contactin-associated protein 1
- Neuronal cell adhesion molecule
- Leucine-rich glioma-inactivated protein 1
- Amyloid-beta precursor protein
- Potassium voltage-gated channel subfamily A member 5
- Receptor-type tyrosine-protein phosphatase zeta
- Neuropilin-1
Sequence:
MGTHARKKASLLLLVLATVALVSSPGWSFAQGTPATFGPIFEEQPIGLLFPEESAEDQVTLACRARASPPATYRWKMNGTDMNLEPGSRHQLMGGNLVIMSPTKTQDAGVYQCLASNPVGTVVSKEAVLRFGFLQEFSKEERDPVKTHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDPRLFAPSIKARFPPETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWATAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPMVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRQNPVRRLIPAARGGEISILCQPRAAPKATILWSKGTEILGNSTRVTVTSDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINVGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRASAKETIGDLTILNAHVRHGGKYTCMAQTVVDGTSKEATVLVRGPPGPPGGVVVRDIGDTTVQLSWSRGFDNHSPIAKYTLQARTPPSGKWKQVRTNPVNIEGNAETAQVLGLMPWMDYEFRVSASNILGTGEPSGPSSKIRTKEAVPSVAPSGLSGGGGAPGELIINWTPVSREYQNGDGFGYLLSFRRQGSSSWQTARVPGADAQYFVYGNDSIQPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPAKVWAKGSSSSEMNVSWEPVLQDMNGILLGYEIRYWKAGDNEAAADRVRTAGLDTSARVTGLNPNTKYHVTVRAYNRAGTGPASPSADAMTVKPPPRRPPGNISWTFSSSSLSLKWDPVVPLRNESTVTGYKMLYQNDLHPTPTLHLTSKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVESAAARPAHPGPAFSCMVILMLAGYQKL
Protein: Protein UPS1, mitochondrial (Unprocessed MGM1 protein 1) (Q05776)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for maintenance of normal mitochondrial morphology. Required for PCP1-dependent processing of MGM1. The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid release requires dissociation of the UPS1:MDM35 complex. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane. With UPS2, controls the level of cardiolipin in mitochondria. Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:26235513}; Peripheral membrane protein {ECO:0000269|PubMed:26235513}; Intermembrane side {ECO:0000305}. Mitochondrion intermembrane space {ECO:0000269|PubMed:26235513}. Note=Lacks the two major intermembrane space-targeting signals, bipartite presequences and cysteine motifs, and import is mediated by another IMS protein, MDM35. {ECO:0000305}.
Interaction partners:
- Mitochondrial distribution and morphology protein 35
- Phosphatidate cytidylyltransferase, mitochondrial
- Cardiolipin synthase
- Protein UPS2, mitochondrial
- Phosphatidylglycerophosphatase GEP4, mitochondrial
- Mitochondrial distribution and morphology protein 31
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Dynamin-like GTPase MGM1, mitochondrial
- Mitochondrial distribution and morphology protein 32
Sequence:
MVLLHKSTHIFPTDFASVSRAFFNRYPNPYSPHVLSIDTISRNVDQEGNLRTTRLLKKSGKLPTWVKPFLRGITETWIIEVSVVNPANSTMKTYTRNLDHTGIMKVEEYTTYQFDSATSSTIADSRVKFSSGFNMGIKSKVEDWSRTKFDENVKKSRMGMAFVIQKLEEARNPQF
Protein: Large ribosomal subunit protein cL38 (50S ribosomal protein 6, chloroplastic) (CL25) (Plastid-specific 50S ribosomal protein 6) (PSRP-6) (Q9FKP0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Large ribosomal subunit protein cL37
- Small ribosomal subunit protein bTHXc
- Large ribosomal subunit protein bL21c
- Small ribosomal subunit protein cS22
- Large ribosomal subunit protein uL24c
- Large ribosomal subunit protein bL27c
- Large ribosomal subunit protein bL28c
- Large ribosomal subunit protein bL20c
- Large ribosomal subunit protein uL18c
- Small ribosomal subunit protein uS13c
Sequence:
MSVSAIFGTGIVTVAASPVLRQFQVPKLGNGGGLGMVIECSSRPQKKSTAHHRKTRPKKTQPWDIKRKPTVYAPLPPLPAEWSPFTLASDDGGAATAAGDLVSGAA
Protein: Platelet-activating factor receptor (PAF-R) (PAFr) (P46002)
Organism: Rattus norvegicus (Rat)
Function: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-15
- Toll-like receptor 4
Sequence:
MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
Protein: Uncharacterized protein C16C6.03c (O42927)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized protein C19G7.18c
- Inner kinetochore subunit mhf2
Sequence:
MNPTSFIYDKPPPPPIINKPFEQTNSSASLTQKNSSSETENVGRHGKRRMDQDLSFKPTKRGSGRGRGRSFRGGSHAGNTRGACAVDGIEYLKRRNISINTPEEIEAWIQERKKNWPTESNIRSKQEKEKVMENLGAADTSQSIDAQPTPSQHPLAHHEPHEKRGPPKKKSLYTKLLNTQLEQENIFFLQFMKLYLKKMGMVVKPVS
Protein: Inhibin alpha chain (P17490)
Organism: Rattus norvegicus (Rat)
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subcellular location: Secreted.
Interaction partners:
- Inhibin beta A chain
- Activin receptor type-2A
- Activin receptor type-2B
- Inhibin beta B chain
- Transforming growth factor beta receptor type 3
- Muellerian-inhibiting factor
- Inhibin beta C chain
- Lutropin-choriogonadotropic hormone receptor
- Bone morphogenetic protein 15
Sequence:
MVIQPSLLLLLLLTLQDVDSCQGPELVRELVLAKVKALFLDALGPPAMDGEGGGPGIRRLPRRHALGGFMHRTSEPEEEDVSQAILFPATGATCEDQAAAGGLAQEPEEGLFTYVFRPSQHIRSHQVTSAQLWFHTGLDRKSTAASNSSRPLLDLLVLSSGGPMAVPVSLGQSPPRWAVLHLAASAFPLLTHPILVLLLRCPLCSCSGRPETTPFLVAHTRARAPSAGERARRSAPSMPWPWSPAALRLLQRPPEEPSAHAFCHRAALNISFQELGWDRWIVHPPSFIFHYCHGSCGMPTSDLPLPVPGAPPTPAQPLFLVPGAKPCCAALPGSMRSLRVRTTSDGGYSFKYEMVPNLITQHCACI
Protein: Protein FAM110B (Q8TC76)
Organism: Homo sapiens (Human)
Function: May be involved in tumor progression.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17499476}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17499476}.
Interaction partners:
- Centrosome and spindle pole-associated protein 1
Sequence:
MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKVFGNHAKTESGVQRENLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRSEATDLHRHSFAESLKVYPTQGRRSPQEGGSHVGRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSSSAPPLPPKPKIAAIASMKSPEADPVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV
Protein: BRCA2 (Q8R4X4)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Interaction partners:
Sequence:
KNCSHIQPWETDCLSCLPERQCEYDPKGPKVSDGKEEVLVSACHPAGQHTAAAQPSSISFELQEDPVNGHNSTSPKETPSLKVLLSKPVVLSRGKVSCKMPEKLQCESYKDNTELSKSIPLGGNKIHILSENSKPPELLPPGKYVTEASPTVKSQFNQNTNLAVKKNDQEETPFISEVTVNVSSGELFPDNENNFAFQVTHENNKTALGSTVELQEEDLRHAKGPNLNNSPTAVDGDIGDEQAAHALIMEDSDSSALVHECAKKSRNTIEQHLKGTTDKDFNSSLDVKSDGNNDYTDKWPGFLDPVFKHKFGGSFRTASNKEIKLSEHNVKKSKMFFKDIEEEYPTSLTCIDIVNASPLANQEILSGPYTFDLQSVTTMSAHPQSQASVSCEDTHTSLQVLPSKQDFHSNHNLTPSQKAEITELSTILEESGSQFEFTQFKKPSHVAQNNIPEVPGKQTVAINTTSEGWKRIGLHLTVDPASVAQTDDSKKFEGSAGFRQSFPCLLKSSCNKNTSSFLANVNEMEFRGFRSALGTKLSVSSEALQKAVKLFSDIESGSEETSTKVDPRALSSGARHDSGASVFKIRKQNSGKSFDEKTSKCQVTLQNNTEVTTGIFVDRNPENYARNTKCEDNNSTGFQRSPYKLKNSEDSESSTSGTVSVHQDDGDLPCAADHCSKYPESCSQYVREENTQIKECVSDLTCLEVMKAEETCYIQPSDKEQLPSGKMEQNRKDFNISFQTASGKNVRVSEESLSKSMNILNQVTDESIISSDSLNSKFHCGTNNNKMGISHHKETTSTKKVFEERFPVGTVSQLPTLQQHPRCEIESIKEPALLGFHTASGKKVKIMQKSLDKVKNLFDETQYVSHQGSKPLKDRENCKEGLALGCETIEIPASKCEEMQKSFLSKESEVLSKQSDRLYRSTENLRTSNGTSSKANVHGNIESEIEKSPTTCCISHLSYSVTEDSALTCDTGHGRKTCVSESSLSKDRKWLRDRLGDKLQKRDAAEIECVKEHTEGYAGDASCEHSLDSIRNEVDINCVSENQTSALFSDPSMCHSCPSHFGCHCDNKHNDSGYFSKNKIYSDTQPDTKNEDTANFSSVYATKEVNIYPPTVNEDICVQKLETNSSPHTNKNVAIDLAIADSRNCKVCPSKFITDHSQETVKTVKAIFTHNSDKTIKQNTKSKPDTCRTSCQKALDNSEDFICPSSLEDDYMNSHKTSVYTHDEQILQHNLSVSGLEKAQIPPVHLETWDKCKSTRELAQAACSSHMPGIFSTASGKAVQVSDASLEKARQVFSEMDGGAKQLLSTLSLESHEQSDHSGRRENSVTHNPEDVLSLPKTFASNANSSVFSGFSTAGGKRVTVSESALHKVKGMLEEFDLIGTEHTLQCPPTSEGVSKILPQYCVEKRTPEYPINSKLQKTYDDKFSLPNNYKESASLGNTHSLEASPQLSQFKQDTRLVLGTKVSLLEKEQTFPQNIKTESGVMET
Protein: Slr1944 protein (P74506)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
Sequence:
MIDFKRLLGIALTSSLLVLASPSVIKGAETITFSIMPLGQFDISVKSLTDFAETGTIDPDFKFYTQHLKPEELEKLRGLLNHSFKFNSVEAFRFFNTTFGKEIAQQLSYIIAAPTDQSQPFLEGAIVTAAQNPDGFKIIDVINAYGGSDLVLNLDTFKNTIDQADTLYQATDRIFTWLGKQEIPSNPVPPNLKPLALAEPGPQKWTTQNLTIPRPNGQPVNVFVYLPQGNSSPAPLVVIAPGLNSNFQAFTYIADHLASYGFTIAGIDFPESDAARMQDSLQGLDAFPDPNAWLEQPKDVTLVLDTLAQKAATDPAWQGKFDINNVGILGHSLGGYTAIASGGATLEWPELLQQCEQLNKPNQINLNPALLWQCQGVGSAPPASNLRESRIKAVLAINPVTNPIFGPDGMKNLAVPTLIVAGSKDIFAPPVPEQIIPFSLIEGVNKYLLLVQNGTHLSFLEDTDNLPEKIVGPGQDLAYTYMKSLGLAFFDLYLQQDSSFKPYLTDSVVQQMSQEPLPLQLVPSLTPAQLQQAMDINN
Protein: Calpain-type cysteine protease family (F4I0A4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEGDERGVLLACVISGTLFTVFGSGSFWILWAVNWRPWRLYSWIFARKWPKVLQGPQLDILCGVLSLFAWIVVVSPIAILIGWGSWLIVILDRHIIGLAIIMAGTALLLAFYSIMLWWRTQWQSSRAVALLLLLGVALLCAYELCAVYVTAGAHASQQYSPSGFFFGVSAIALAINMLFICRMVFNGNGLDVDEYVRRAYKFAYSDCIEVGPVACLPEPPDPNELYPRQTSRASHLGLLYLGSLVVLLAYSVLYGLTARESRWLGGITSAAVIVLDWNIGACLYGFKLLQNRVLALFVAGISRLFLICFGIHYWYLGHCISYIFVASVLSGAAVSRHLSITDPSAARRDALQSTVIRLREGFRRKEQNSSSSSSDGCGSSIKRSSSIDAGHTGCTNEANRTAESCTADNLTRTGSSQEGINSDKSEESGRPSLGLRSSSCRSVVQEPEAGTSYFMDKVSDQNNTLVVCSSSGLDSQGYESSTSNSANQQLLDMNLALAFQDQLNNPRIASILKKKAKEGDLELTNLLQDKGLDPNFAVMLKEKNLDPTILALLQRSSLDADRDHRDNTDITIIDSNSVDNTLPNQISLSEELRLRGLEKWLKLSRLLLHHVAGTPERAWGLFSLVFILETIIVAIFRPKTITIINSSHQQFEFGFSVLLLSPVVCSIMAFLRSLQVEEMALTSKSRKYGFVAWLLSTSVGLSLSFLSKSSVLLGISLTVPLMAACLSIAVPIWMHNGYQFWVPQLSCGDQARDLRSPRIKGFILWICVVLFAGSVISLGAIISAKPLDDLKYKLFSARENNVTSPYTSSVYLGWAMSSGIALVVTAILPIVSWFATYRFSHSSAVCLMIFSVVLVAFCGTSYLEVVKSRDDQLPTKGDFLAALLPLACIPALLSLCCGMVKWKDDCWILSRGVYVFFSIGLLLLFGAIAAVIAVKPWTIGVSFLLVLFLMVVTIGVIHLWASNNFYLTRKQTSFVCFLALLLGLAAFLLGWHQDKAFAGASVGYFTFLSLLAGRALAVLLSPPIVVYSPRVLPVYVYDAHADCGKNVSAAFLVLYGIALATEGWGVVASLIIYPPFAGAAVSAITLVVAFGFAVSRPCLTLEMMEVAVRFLSKDTIVQAISRSATKTRNALSGTYSAPQRSASSAALLVGDPSAMRDKAGNFVLPRDDVMKLRDRLRNEERVAGSIFYKMQCRKGFRHEPPTNVDYRRDMCAHARVLALEEAIDTEWVYMWDKFGGYLLLLLGLTAKAERVQDEVRLRLFLDSIGFSDLSARKISKWKPEDRRQFEIIQESYLREKEMEEESLMQRREEEGRGKERRKALLEKEERKWKEIEASLIPSIPNAGSREAAAMAAAIRAVGGDSVLEDSFARERVSGIARRIRTAQLERRAQQVKTYFYILQVFFLMMLINGELTKKSYYQTGISGAVCVLDDEPMISGKHCGQMDSSVCQSQKISFSVTAMIQSDSGPVCLFGTEFQKKVCWEILVAGSEQGIEAGQVGLRLITKGERQTTVAREWYIGATSITDGRWHTVTITIDADAGEATCYIDGGFDGYQNGLPLSIGSAIWEQGAEVWLGVRPPIDVDAFGRSDSDGVESKMHIMDVFLWGKCLSEEEAASLHAAIGMADLDMIDLSDDNWQWTDSPPRVDGWDSDPADVDLYDRDDVDWDGQYSSGRKRRSGRDFVMSVDSFARRHRKPRMETQEDINQRMRSVELAVKEALSARGDKQFTDQEFPPNDRSLFVDTQNPPSKLQVVSEWMRPDSIVKENGSDSRPCLFSGDANPSDVCQGRLGDCWFLSAVAVLTEVSRISEVIITPEYNEEGIYTVRFCIQGEWVPVVIDDWIPCESPGKPAFATSRKLNELWVSMVEKAYAKLHGSYEALEGGLVQDALVDLTGGAGEEIDLRSAQAQIDLASGRLWSQLLRFKQEGFLLGAGSPSGSDVHVSSSGIVQGHAYSVLQVREVDGHRLVQIRNPWANEVEWNGPWSDSSPEWTDRMKHKLKHVPQSKEGIFWMSWQDFQIHFRSIYVCRVYPREMRYSVNGQWRGYSAGGCQDYSSWHQNPQFRLRATGSDASLPIHVFITLTQGVGFSRTTPGFRNYQSSHDSQLFYIGLRILKTRGRRAAYNIFLHESVGGTDYVNSREISCEMVLDPDPKGYTIVPTTIHPGEEAPFVLSVFTKASIVLEAL
Protein: BSD domain-containing protein C22A12.14c (O13905)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MDLYDYMAPTTTTEEDDEEGYEKLKEEMGSALNNLTNGKFGLFWNSMKEKSENFLDDTKGKASSGMQQLKSQLEENIPVNSAMENLRKVEETAGSFWSGFGSTVNGFLDQALQISPKEDDVSTPTHEASSSVFLNRHERQLLELVQNENTFTQIISEPSHGITFESWEKEISIDGKTEEISLLLEEYPDLRKQMESLVPSEVSYDDFWKRFFWHKEVVQPIKAIQSGNDEEEIFSWGDERSDEEESDNEQVNDEKKQSSEEDTTENNSAAEVIDETVNDLESAVSKGLQIETQPASHDGEVDGEVKEEEENKVSSSSNIEASQSSLEVKDEANRKVDDDDEDDDDWE
Protein: Heme-binding protein HMX1 (P32339)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays an important role in the degradation of heme under conditions of iron deprivation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11566881, ECO:0000269|PubMed:12840010}; Single-pass type IV membrane protein {ECO:0000269|PubMed:11566881, ECO:0000269|PubMed:12840010}.
Interaction partners:
- NADPH--cytochrome P450 reductase
- mRNA decay factor CTH2
- Siderophore iron transporter ARN1
- Ferrochelatase, mitochondrial
- Oxygen-dependent coproporphyrinogen-III oxidase
Sequence:
MEDSSNTIIPSPTDVGALANRINFQTRDAHNKINTFMGIKMAIAMRHGFIYRQGILAYYYVFDAIEQEIDRLLNDPVTEEELQTSTILKQFWLEDFRRSTQIYKDLKLLYSNTFKSTESLNEFLATFQKPPLLQQFINNIHENIHKEPCTILSYCHVLYLALFAGGKLIRSNLYRRLGLFPNFEKLSQKELVKKGTNFFTFSDLGPTEETRLKWEYKKNYELATRTELTEAQKLQIISVAEGIFDWNFNIVAEIGELNRRELMGKFSFKCITYLYEEWMFNKDSATRRALHTVMLLVLSIIAIWVLYFLVKSFLSIV
Protein: Neogenin (P97603)
Organism: Rattus norvegicus (Rat)
Function: Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response (By similarity).
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Repulsive guidance molecule BMP co-receptor a
- Hemojuvelin
- Netrin-1
- Bone morphogenetic protein 2
- Bone morphogenetic protein receptor type-1A
- Netrin receptor UNC5B
- Focal adhesion kinase 1
- Rho guanine nucleotide exchange factor 12
- Serine/threonine-protein kinase receptor
- Netrin-3
Sequence:
AAAKNGSPPQSAGASVRTFTPLYFLVEPVDTLSVRGSSVILNCSAYSEPSPNIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGFYQCVATVDNLGTIVSRTAKLAVAGLPRFTSQPEPSSIYVGNSGILNCEVNADLVPFVRWEQNRQPLLLDDRIVKLPSGTLVISNATEGDEGLYRCIVESGGPPKFSDEAELKVLQESEEMLDLVFLMRPSSMIKVIGQSAVLPCVASGLPAPVIRWMKNEDVLDTESSGRLALLAGGSLEISDVTEDDAGTYFCVADNGNKTIEAQAELTVQVPPEFLKQPANIYARESMDIVFECEVTGKPAPTVKWVKNGDVVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGVARERVENTSQPGEMQVTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNIRAYATSPTSITVTWETPLSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVRTLSDVPSAAPQNLSLEVRNSKSIVIHWQPPSSATQNGQITGYKIRYRKASRKSDVTETVVTGTQLSQLIEGLDRGTEYNFRVAALTVNGTGPATDWLSAETFESDLDESRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGATFELVPTSPPKDVTVVSKEGKPRTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQALGSAGKGGRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSIGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNCKDVKPPDLWIHHERLELKPIDKSPDPNPVMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQQSVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPIYDPALPSTPLLSQQALNHHLHSVKTASIGTLGRSRPPMPVVVPSAPEVQEATRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA
Protein: NADPH:quinone oxidoreductase MdaB (EC 1.6.5.10) (Modulator of drug activity B) (P0AEY5)
Organism: Escherichia coli (strain K12)
Function: NADPH-specific quinone reductase. Is most active with quinone derivatives and ferricyanide as electron acceptors. Can use menadione, 1,4-naphthoquinone and 1,4-benzoquinone. May work in concert with YgiN to form a quinone redox cycle.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8611590}.
Interaction partners:
- Probable quinol monooxygenase YgiN
- Uncharacterized NAD
- FMN-dependent NADH:quinone oxidoreductase
- Oxygen-insensitive NADPH nitroreductase
- Quinone reductase
- Glutathione-regulated potassium-efflux system ancillary protein KefF
- Oxygen-insensitive NAD
Sequence:
MSNILIINGAKKFAHSNGQLNDTLTEVADGTLRDLGHDVRIVRADSDYDVKAEVQNFLWADVVIWQMPGWWMGAPWTVKKYIDDVFTEGHGTLYASDGRTRKDPSKKYGSGGLVQGKKYMLSLTWNAPMEAFTEKDQFFHGVGVDGVYLPFHKANQFLGMEPLPTFIANDVIKMPDVPRYTEEYRKHLVEIFG
Protein: Sesquiterpene synthase (SaSesquiTPS1) (EC 4.2.3.-) (B5A435)
Organism: Santalum album (White sandalwood)
Function: Sesquiterpene synthase producing the monocyclic sesquiterpene alcohol germacrene D-4-ol and helminthogermacrene and minor amounts of bicyclic compounds such as alpha-bulnesene, gamma-muurolene, alpha- and beta-selinenes, when incubated with farnesyl diphosphate.
Interaction partners:
Sequence:
MENQKVPISSVPNLKELSRPIANFPPSIWGDRFINYACEDENEQAQKERQVEELKEQVRRELAATVDKPLQQLNIIDATQRLGIAYHFENEIEESLEHIYLHTYVENNCFQGSHDLYSVALWFRLLRQDGYKVSCDVFDKFRDYEDNFKNSLMEDAKGLLELYEATHLSVHGEEMLDDALEFAKTRLESIVNHLNYPLAEQVRHALYRPLRKGLPRLEAVYFFRIYEAYDSHNKALLKLAKLDFNLLQSLHKKELSDMARWWKSLDFAAKFPFARDRLVEGYFWVLGVYFEPQYSLARKIIIKVFTMISTIDDIYDAYGTLDELELFTKAMQRWDVGSLDQLPEYMKPCYKSILDVYNEIEEEMDNQGSLFRMHYAKEVMKKLVEGYMDEAKWCHEKYVPTFEEYMPVALVTSGYTFLTTISYLGMGEIASKEAFDWLFSHPPVIEASESVCRLMDDMRSHKFEQERGHVASGIECYMKQYGVTEEEAHDEFRKQLVKAWKDINEECLRPYRVPKPLLMRILNLTRVIDVIYKNEDGYTHVKKAMKDNIASLLIDPMIV
Protein: Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) (Q71V39)
Organism: Oryctolagus cuniculus (Rabbit)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q05639}.
Interaction partners:
Sequence:
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK
Protein: Cadherin-5 (Vascular endothelial cadherin) (VE-cadherin) (Q8AYD0)
Organism: Gallus gallus (Chicken)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.
Subcellular location: Cell junction, adherens junction {ECO:0000250|UniProtKB:Q68SP4}. Cell membrane {ECO:0000250|UniProtKB:P33151}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P33151}. Cytoplasm {ECO:0000250|UniProtKB:P55284}.
Interaction partners:
- Vascular endothelial growth factor receptor 2
- Platelet and endothelial cell adhesion molecule 1.
- Plakoglobin
- Claudin
- Catenin beta 1
- Catenin delta 1
- Uncharacterized protein.
- Cadherin-1
- Uncharacterized protein
- Catenin alpha 1.
Sequence:
MKKLILLFSLFLAPAFSYKENQKINQNFSSNNTSHKRLKRDWIWNRMHIREEIDSPLPHHVGKLTSSVGNKNAMYIIEGESANTIFKVQGYDGDIYAFERLDREKKAEYELTAHIIDRRNNRSLEPPSKFIIKVSDINDNAPIFVQKIFNGSVPEMSRLGTSVTKVTAEDADDPTVAGHATVTYQIIKGNEYFTVDDSGVISTARADLDRESQSAYEIIVKAKDALGLTGESSTATVIIRLTDINDNFPVFKHPSFHFRVPENISVGGEVGRVKVEDIDEPQHRNTKYSFVRGDYRDTFEIIANPFTNEGIIRPKKPLDFEKVAEYRFDIEATDHNVNPAYYKPGGSRSISTITIEVTDVDEPPVFTKLSYEFKVRENDPEIKTLGSVWAHDPDAAKRKIRFARRRASPNGDYVRVSDSGIIQLPKPLDREFSSLYNITVAAQEILEDGRLSDRESHAQVHVIVTDENDNAPELVYPEEPRVCENAAPGKVIIRISATDKDEISPGGFFTYSLTTEDSNFSLTENPDNTANITVKDGQFNRELAKIHYLPVIISDNGNPELSSTNTLVISVCKCNEKGDFTFCEERAKQVGVSVQALVAIFICIFTIIAVIALLILLRKRHKKDLSGLRRNVAEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRKNGIKPEVVPSAYAQVQKPPGNTTSGAGEMEMMIEVKKDEADNDRDLLPYDTLHIYGYEGAESIAESLSSLESGSSDSDIDYDFLNDWGPRFKMLAELYGSEPNEDFVY
Protein: B1 kinase (Serine/threonine-protein kinase 1) (EC 2.7.11.1) (Vaccinia protein kinase 1) (P16913)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Essential serine/threonine-protein kinase that plays different role in the viral life cycle. Phosphorylates the host small ribosomal protein RACK1 thereby customizing the ribosomes to a state optimal for viral mRNAs (which contain poly-A leaders) but not for host mRNAs. Facilitates viral DNA replication by inhibiting host BANF1, a cellular host defense responsive to foreign DNA. Phosphorylates host BANF1 on serine and threonine residues; this leads to BANF1 relocalization to the cytoplasm, loss of dimerization and impaired DNA binding activity. Indeed, BANF1 activity depends on its DNA-binding property which is blocked by VPK1-mediated phosphorylation. Required for viral intermediate genes expression, probably by inhibiting host BANF1. Modulates cellular responses via host JUN by two different mechanisms, either by direct phosphorylation or by modulation of upstream JIP1-MAPK complexes. Seems to participate in the accumulation/processing of late proteins and thus in virion maturation. In addition, inhibits B12 repressive activity on viral DNA replication via a phosphorylation-dependent mechanism.
Subcellular location: Virion {ECO:0000269|PubMed:1448924}. Host cytoplasm {ECO:0000269|PubMed:1448924}. Note=Localizes in cytoplasmic viral factories and is a minor component of the virion. {ECO:0000269|PubMed:1448924}.
Interaction partners:
Sequence:
MNFQGLVLTDNCKNQWVVGPLIGKGGFGSIYTTNDNNYVVKIEPKANGSLFTEQAFYTRVLKPSVIEEWKKSHNIKHVGLITCKAFGLYKSINVEYRFLVINRLGADLDAVIRANNNRLPKRSVMLIGIEILNTIQFMHEQGYSHGDIKASNIVLDQIDKNKLYLVDYGLVSKFMSNGEHVPFIRNPNKMDNGTLEFTPIDSHKGYVVSRRGDLETLGYCMIRWLGGILPWTKISETKNCALVSATKQKYVNNTATLLMTSLQYAPRELLQYITMVNSLTYFEEPNYDEFRHILMQGVYY
Protein: GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (Q8I5H7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase
- Vacuolar protein sorting-associated protein VTA1, putative
- Inosine triphosphate pyrophosphatase
- Bis
- Alkaline phosphatase, putative
- 6-pyruvoyltetrahydropterin synthase
- Nucleoside diphosphate kinase
- nucleoside-diphosphate kinase
- Coronin
- Guanylate cyclase beta
Sequence:
MYKYTSINKSDKIYETHNMEEKKKKGNNNNFSGLLNNEIDDNNKKEKLKNSISKMYSNHKNRENFNECEKEDLVVIDEKDNNKKKKKNMTNTFEQDNNYNMNDNKRLGSFFKINDKCESINENVNNINKQSLKDSILFDNINEKEYFNETKEENKEGNKSNDIEKINCMKVKKKTVKKNKKKINKIINNKNKISKSNDIEEQIINISKHIYKILNISKLPKCDILKRTNRRYAETFLYLTNGYNLDIEQIIKRSLYKRMYKNNSIIKVTGIHIYSLCKHHLLPFEGTCDIEYIPNKYIIGLSKFSRIVDVFSRRLQLQEDLTNDICNALKKYLKPLYIKVSIVAKHLCINMRGVKEHDAKTITYASYKAEKENPTVHSLNIDSSVENLN