wanglab/gogpt-training-data huggingface dataset:
Protein: Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14) (Q9VBW3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Fibroblast growth factor
- Growth factor receptor-bound protein 2
- FI23523p1
Sequence:
MVYHHHNHESRIIHCRKQLTSWRRRSLLLTIIVVTATVVSLISQEAEAHNQNAPPILYVRERNWRISETEKVGQIIDRVRAEDPDGDDLIFGIEPRFSLPGGENDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTDGSYTAKNEVFINILGERENSSGYRPQTSISNVVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKLTPITANNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLKSGTIPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIELERFPDHNYYNIVSLSGEKL
Protein: Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0281 (EC 2.1.1.-) (P9WFI9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Interaction partners:
- ESX-3 secretion system protein EccC3
- ESX-3 secretion system protein EccA3
- ESX-3 secretion system ATPase EccB3
- Uncharacterized PPE family protein PPE3
- S-adenosyl-L-methionine-dependent methyltransferase
- ESAT-6-like protein EsxG
Sequence:
MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCRAVGGSWADVLDGKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRRAAAAGARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASHGAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIYLPATAQERLFTGIDALAGRRSHVAVEDGAPMGPDEYAAKVEEERAAIAEGAEEHPFFQLVYNERCAPAAEWFGERGWTAVATLLNDYLEAVGRPVPGPESEAGPMFARNTLVSAARV
Protein: Uncharacterized protein (Q386U0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}.
Interaction partners:
- Rhodanese domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- MICOS complex subunit MIC10
- Transmembrane protein
- Mitochondrial fission process protein 1
- Thioredoxin domain-containing protein
Sequence:
MSEQRVSQPKTPVSNEEKWDHSLENFFRKTTLGLAYSILPAFLLARSAAARGAILMFATGIGSGIAYGEARYLFDHDVVFDRRHLVHIELLKPKESKIN
Protein: Mitogen-activated protein kinase kinase kinase 9 (MAP kinase kinase kinase 9) (EC 2.7.11.24) (MAPK/ERK kinase kinase 2) (AtMEKK2) (Protein SUPPRESSOR OF MKK1 MKK2 1) (O81472)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Triggers SUMM2-mediated immune responses, including cell death and defense responses. Probably inhibited by the MEKK1-MKK1/ MKK2-MPK4 kinase cascade to adjust plant defense. Seems to contribute in transducing external glutamate (L-Glu) signal that elicits large-scale changes in root architecture.
Interaction partners:
- Mitogen-activated protein kinase 4
- Disease resistance protein SUMM2
Sequence:
MKKSSDKSPVRQHDTATQINSDAVSSSTSFTDSDSTCSFLTPSMEFPDRISFRRIDFSEAAPTGVVLPSTSSELTRSNSSENKIPNEDISVSTSSRYLVFDKILALMKKSPGRRGDKTSPARRLDRSDAVRRNIDYDAGEDSSSLLITRSLDFPNRTSFRVDGVDDGEIDRIYQYIGVSGPEDFAISSDAWKARMEHERSSSDVVNKLKSLDLDSREAGPSGGVVASSSMNHKFQGHDLSEAGSIGVVVASNFTLSESNKIENLNSLRDKEIVDGDMVENRCGIERKPTILVKSRGYLVHNDDVGVGGGIKGVRPPVLNVPRADKEVVDGGTVESKSGIEWKPTILVKSKGYLVSNDGGIKGVTSPVLNLRPTDKEVVDSGTVENRRGIKGVRPSVLKPPPVMKLPPVDLPGSSWDILTHFAPDSEIVRRPSSSSSSENGCDEEEAEDDKVEKEETGDMFIQLEDTTDEACSFTTNEGDSSSTVSNTSPICVSGGSINTSWQKGQLLRQGSFGSVYEAISEDGDFFAVKEVSLLDQGSQAQECIQQLEGEIALLSQLEHQNILRYRGTDKDGSNLYIFLELVTQGSLLELYRRYQIRDSLISLYTKQILDGLKYLHHKGFIHRDIKCATILVDANGTVKLADFGLAKVSKLNDIKSRKETLFWMAPEVINRKDNDGYRSPADIWSLGCTVLEMCTGQIPYSDLEPVEALFRIRRGTLPEVPDTLSLDARHFILKCLKLNPEERPTATELLNHPFVRRPLPSSGSGSTSPLIRR
Protein: Uncharacterized protein (Q57TY3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVFSTHGIRVVYNTANVDRSLYAVVHCSDGKYAEVSKDHLNRLKFIEKSSEEEDIEFDYPEAVLESLAQWTLKYGMDGVAVSSTVRPCIYRNVQHVLKDDWEREFFTTRLMNDLNIMHYLQTINAAEKYEMKGFHDFLCVCLSCKLRNEEDTELVHKIMGLEDFVEIGPSDLDEAACRYTWLDQAIKPTVRR
Protein: Epididymis secretory sperm binding protein (A0A384MDT2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MMLSTEGREGFVVKVRGLPWSCSADEVMRFFSDCKIQNGTSGIRFIYTREGRPSGEAFVELESEEEVKLALKKDRETMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYGGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSSFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVEFATHEDAVAAMAKDKANMQHRYVELFLNSTAGTSGGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDYQSNLA
Protein: Sialic acid-binding Ig-like lectin 12 (Siglec-12) (Myeloid inhibitory siglec) (MIS) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (Sialic acid-binding Ig-like lectin E) (Siglec-E) (mSiglec-E) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Q91Y57)
Organism: Mus musculus (Mouse)
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Mucin-1
- Amine oxidase [copper-containing] 3
- Tyrosine-protein phosphatase non-receptor type 11
- Toll-like receptor 4
- Toll-like receptor 2
- Elongation factor 1-alpha 2
Sequence:
MLLLLLLLLLWGIKGVEGQNPQEVFTLNVERKVVVQEGLCVLVPCNFSYLKKRLTDWTDSDPVHGFWYREGTDRRKDSIVATNNPIRKAVKETRNRFFLLGDPWRNDCSLNIREIRKKDAGLYFFRLERGKTKYNYMWDKMTLVVTALTNTPQILLPETLEAGHPSNLTCSVPWDCGWTAPPIFSWTGTSVSFLSTNTTGSSVLTITPQPQDHGTNLTCQVTLPGTNVSTRMTIRLNVSYAPKNLTVTIYQGADSVSTILKNGSSLPISEGQSLRLICSTDSYPPANLSWSWDNLTLCPSKLSKPGLLELFPVHLKHGGVYTCQAQHALGSQHISLSLSPQSSATLSEMMMGTFVGSGVTALLFLSVCILLLAVRSYRRKPARPAVVAPHPDALKVSVSQNPLVESQADDSSEPLPSILEAAPSSTEEEIHYATLSFHEMKPMNLWGQQDTTTEYSEIKFPQRTAWP
Protein: Cyclin-H (O76513)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cyclin-dependent kinase 7
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIH subunit 3
- General transcription factor IIH subunit 4
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIH subunit
- General transcription factor IIH subunit 1
- General transcription factor IIE subunit 1
- Cyclin-dependent kinase 9
Sequence:
MYPVSSQKRSWTFANEGQLMEFRVEQNSKYIESHEEEAQGRDLNEHFLTSAEERLLLKQYEIYLFDFCRRFEPTMPKCVVGTAFHYFKRFYLNNSPMDYHPKEILATCVFVACKVEEFNVSINQFVNNIKGDRNKATDIVLSNELLLIGQLNYYLTIHNPFRPIEGFLIDIKTRSNMQNPDRLRPHIDSFIDSTYYSDACLLHTPSQIALAAVLHAASREQENLDSYVTDLLFVSAREKLPGLIDAVRKIRIMVKQYQQPDREKVKAIEKKLDKCRNQANNPDSELYKERLRRLYTDEDDMPAEDASFHIADVSSDTSAMNISQ
Protein: SET domain-containing protein 2 (A0A8I6AUV5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKQLPSQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPIFKGVASSRFLPKGTKTKVNLEEQGRQKVSFSFSLTKKTLQNRFFTALSNEKQSDSPHSPATPQVDSNPKAKMEAGDTFPATEESSPPKSRVELGRIHFKKHLLHVTSRPQLATTTTVASLLPPTTQLPVAIAESTVDSPPSSPPPPPPPPQVSSPSPPAPISEPVALPHPPVTALMTSTPGPLPVDAAVRAQKEPPMKSVPESLELDMKQDIVSNSLEEHTNQTLKEQADNALQKEDSHIGKEEEVSDGSKISLSSKKASSKKKSSQFEGTFLGSESDEDSVRTSSSQRSHDLKSSTSIEKERDFKKSSAPSKSEDLGKSSRSKTERDDKYFSYSKLERDTRYVSTRCRSERDRRRSRSRSRSDRVSRTSLSYSRSERSHYYDSERRYHRSSPYRERTRYSRPYTDNRARESSDSEDEYKKTYPRRTSAHSYRDLRTSSSYSKFDRDCKTETSYLEMERRGKYSSKLERESKRTSEHEAIKRCCSPPNELGFRRGSSYSKHDNNSTSRYKSALSKSISKSDKFKNSFCCTELNEENKQSHSFSLQTPCSKGSELRTINKIPEREKTGSPSPSNQLNDSPTFKKLDESPILKPEFIGHDSHESIKELELPKMKNDQLRNFCSIELNVNGSPETETDVATFRTSKPDAISMTSDDSVTGSEVSPLIKGCVLSSNGFQSVGRCRERDADDACRQHNKSKSPFRETEPLLSPHHDKVMSLPVKTIDYSKTLIKEPVDKRHSCCKTKDSDRYCSPNESSEAENREISSNCFVNVHLDSKTVVCDNRELTDQHSEFTCDGYKQSIGSTSSASLNHFDDLYESVGSSGISSLQSLPSGIRCEENTSPALDTVQSKKGIDFLKYVGKETDVVSALPDSGKAFSSWENRHNMLSGQSLQESQEEGSSTLHERRGRSEVSLDEEEQRGHTHISDDSEVVFPYDLNLTMEDSDGVTYTLKCDSSGNAPEIVSTVHGDYSASSASSSDESDSEDTESDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDGLESRRHAYEEKFESMASKGCSQTEKFFLHKGTERNPETSYSQFSRKIDNHLPEIAHSQSDGVDSTSHTDVKSDSVGHLNSEDAIRAKMSRPQELPVYCDDFEDLPNTSRQQMIFSNRPDSSRLGKAELSFSSSCDISRMDGLHSSEELRNLGWDFSQQERPTTTYQQPDSSYGTCGTHKYQQSAEHYGGTHDYWQGNGYWDPRSAGRPPGTGVVYDRIQGQVPDSLTDDREEEENWDQRSGSHFSSPSNKFFFHQKDKGSVQAPEISSNSIKDSLVINERKDFSKNFEKNDIKERGPPKKRRQELESDSESDGELQARKKVRVEIEQGQSSVPQHSELVGPSCAMDDFRDPQRWKEFAKLGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEVACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLKLIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPQLSEGDGYSSENTSRAHTPLNTPDPSAKPSTEVDTDTPKKLIFRRLKIISENSMDSAVSDVTSELECKDGKEDLDQLETVTVEEDEELQSQQLLPSQLCESKVESESTIDVSKLPISEPEADTETEPKDSNGTKLEETIAEETPSQDEEEGVSDVESERSQEPPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKESTVTERGRDTAAFRDQTAPKTPNRSREREPDKQSQNKEKRKRRGSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPFDSLGYNASHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTESLAAPPSVPVVPHGAASVEVSSSQYAAQSESVVHQDSSVPGMPVQTPGPVQGQNYSVWDSNQQSVSVQPQYSPAQSQATIYYQGQTCSTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPPEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKCVPYS
Protein: Gnt-II system L-idonate transporter (L-Ido transporter) (L-idonate transporter) (5-keto-D-gluconate transporter) (L-idonate/5-ketogluconate/gluconate transporter) (P39344)
Organism: Escherichia coli (strain K12)
Function: Transports L-idonate, D-gluconate and 5-keto-D-gluconate, from the periplasm across the inner membrane.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable 3-phenylpropionic acid transporter
- Siroheme synthase
- 5-keto-D-gluconate 5-reductase
- Thermosensitive gluconokinase
- Uncharacterized protein YjgR
- HTH-type transcriptional regulator IdnR
- L-idonate 5-dehydrogenase
Sequence:
MPLIIIAAGVALLLILMIGFKVNGFIALVLVAAVVGFAEGMDAQAVLHSIQNGIGSTLGGLAMILGFGAMLGKLISDTGAAQRIATTLIATFGKKRVQWALVITGLVVGLAMFFEVGFVLLLPLVFTIVASSGLPLLYVGVPMVAALSVTHCFLPPHPGPTAIATIFEANLGTTLLYGFIITIPTVIVAGPLFSKLLTRFEKAPPEGLFNPHLFSEEEMPSFWNSIFAAVIPVILMAIAAVCEITLPKTNTVRLFFEFVGNPAVALFIAIVIAIFTLGRRNGRTIEQIMDIIGDSIGAIAMIVFIIAGGGAFKQVLVDSGVGHYISHLMTGTTLSPLLMCWTVAALLRIALGSATVAAITTAGVVLPIINVTHADPALMVLATGAGSVIASHVNDPGFWLFKGYFNLTVGETLRTWTVMETLISIMGLLGVLAINAVLH
Protein: Inositol 5-phosphatase 4 (RhoGAP domain-containing protein) (Q8I7P3)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasmic vesicle, phagosome membrane {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004146}.
Interaction partners:
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Phosphatidylinositol 4-kinase
- Phosphatidylinositol 3-kinase 1
- phosphoinositide 5-phosphatase
- SAC domain-containing protein
- 1-phosphatidylinositol 4-kinase
- 1-phosphatidylinositol 4-kinase
- LIM-domain containing phosphatase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Sequence:
MGDIQNTDNIESNIDNNNNNNVSLESSSSSQNNNTNTTTTTTTTSVDNLQVGVLSISDQSTPTIETPNQQQQQQQDDNNRGVSNETIKASLDGLKHNSLKTTFPNSTNHQYIDVNTQWITNKLKERESEFTEKRGMSIFLGTWNVNGKKPSESLDPWLKDPSMSLQPDIYAIGFQELDLTAEALLLGDTTRSLPWEQHILNTLQGDYVKLLSKQLVGILLCVYVKKEHKPHIANVQSDIAAVGIMGMMGNKGGVAIRFSFYNTTICILNSHLNAHMDNVLRRNQDMKDISKNIKFINESSTDHSTINIFDHDQLFWIGDLNYRIPLPDNEVKEKIKKKDFYNLFLVDQLNQQMKAGAVFEGFQEPPISFAPTYKYDAGTEEYDSSEKKRTPAWCDRILWKTHKKAENVGILSYKRAELISSDHRPVSASFVIKIKVVIPDSKNRIYQEIVKELDKKENDSMPDANISTNMVDFETIKFMQPISKQLIFENIGQVIARFQFIPKLDETILCKPWLKISPLAGMMIPKEKVTIDLTIYVDNLTSGLFNINNNSTNSTNESMDDILILHLENGKDYFISISGKFQKTCFGNTLDNLVRYPHPIRNNLPIPPEQKKLSIPKELWRIIDYIYYNGLKEEGLFIKSGVTKEMELIRDCLDTAEPFSSISFSIHSMAETLIRFLESLVEPVIPFNMYQQALDASSSPLSCKTLVSHLPSVNYNVFFYLISFLIETLSNQKENDLKPDQLAIIFSTVLLRPSPQSQLSQFPPDATTVKKKADLILHFLISKDLIN
Protein: Proteasome inhibitor PI31 subunit (Q5QPM7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
Sequence:
MAGLEVLFASAAPAITCRQDALVCFLHWEVVTHGYFGLGVGDQPGPNDKKSELLPAGWNNNKDLYVLRYEYKDGSRKLLVKAITVESSMILNVLEYGSQQVADLTLNLDDYIDAEHLGDFHRTYKNSEELRSRIVSGIITPIHEQWEKANVSSPHREFPPATAREVDPLRIPPHHPHTSRQPPWCDPLGPFVVGGEDLDPFGPRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPPGPRPDRRGQ
Protein: Metabotropic glutamate receptor 2 (Q80T43)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
DAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVA
Protein: Transcription initiation factor TFIID subunit 8 (TBP-associated factor 8) (O94706)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification, facilitation of DNA opening and initiation of transcription (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 7
- SAGA complex/transcription factor TFIID complex subunit Taf10
- SAGA complex/transcription factor TFIID complex subunit Taf12
- Transcription initiation factor TFIID subunit 2
- SAGA complex/transcription factor TFIID complex subunit Taf6
- Transcription initiation factor TFIID subunit 13
- SAGA complex/transcription factor TFIID complex subunit Taf9
- SAGA complex/transcription factor TFIID complex subunit Taf5
- TATA-box-binding protein
Sequence:
MEAVIANILQQLGFDSMTKAAEASFVEAVDKYLRNSFRELALHTQLSKHTIPTTKDVALWLNLLNIPMSSLQTELEKYLKPLPPAINDELDRLANESQDIPSKFKSSLDSKMVSQLLGSLAVSQNRPAYVVNHLPPFPASHTYMATPVYPVRPTSPKQIRELATQESRLAEHALRKILNVNQPRSADSPRHASFEKACSELNLDVSSFHLVNWESQKWSSQR
Protein: Phosphorylase b kinase regulatory subunit (A0A8I5ZLG9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}.
Interaction partners:
Sequence:
MRSRSNSGVRLDGYARLVQQTILCYQNPVTGLLSASHDQKDAWVRDNIYSILAVWGLGMAYRKNADRDEDKAKAYELEQNVVKLMRGLLQCMMRQVDKVEKFKHTQSTKDSLHAKYNTATCSTVVGDDQWGHLQVDATSLFLLFLAQMTASGLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIPELNASSVGMAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQSILFSMLPRASTSKEIDAGLLSIISFPAFAVEDVHLVNVTKNEIISKLQGRYGCCRFLRDGYKTPREDPHRLHYDPAELKLFENIECEWPVFWTYLIIDGVFNGDAVQVQEYREALEGILIRGKDGIHLVPELYAIPPDKVDEEYKNPHTVDRIPLGKLPHLWGQSLYILSSLLAEGFLATGEIDPLNRRFSTSVKPDVVVQVAVLAENSHIKGLLKQHGINVQSIADVHPIRVQPGRILSHIYAKLGQNKNMKLSGRPYRHIGVLGTSKLYVIRNHIFTFTPQFTDQHHFYLALDNEMIVEMLRIELAYLCTCWRMTGRPTLTFPVTHTMLTNDGSDIHPAVLSTIRKLEDGYFGGARVKLGILAEFLTTSFYTYLTFLDPDCDEKLFGDISDRSFSPDSESDLGGYLEDSSHQESQDELDQYISHLLQSTSLKCYLPPLCKKSEDSHVFSAVHSTRDILSVMAKAKGLETPFFPMILPTRVLSGHRKSLNLVDSPQPFLKKTPEYDYQWPRDDQDEVDCEKLVGQLKDCSNLQDQADILYILYVIKGPRWDTNLFGQHGVTVHSLLGELYGKAGLNQEWSLIRYISGLLRKKVEVLAEACADLLSHQKQLTVGLPPEPREKTISTPLPPEELTELIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLFAEMLRLRIGLIIQVMATELARSLNCSGEEASESLMNLSPFDMKSLLHHILSGKEFGVERSVRPIHSSMSSPAISIHEVGHTGVTKTERSGISRLRSEMKQRSSTPSSPTGTSSTDSGGHHLGWGEQQGQWLRRRRLDGAINRVPVGFYQRVWKILQKCHGLSIDGYVLPSSTTQEMTPCEIKFAVHVESVLNRVSQPEYRQLLVEAIMVLTLLSDTEMDSIGGIIHVDQIVQLANQLFLQDQVSFGTTDILEKDQATGICHLFYDSAPSGAYGTMTYLTKAVASHLQDLLPSSGCQMQ
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1 (Oligosaccharyl transferase 48 kDa subunit) (Oligosaccharyl transferase subunit beta) (O59866)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000250|UniProtKB:P33767}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P33767}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Uncharacterized protein C553.06
- Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit ost2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3
- Probable protein transport protein Sec61 subunit gamma
- Probable mannosyl-oligosaccharide glucosidase
- Dol-P-Glc:Glc
- Protein transport protein sec61 subunit beta
- Protein transport protein sec61 subunit alpha
Sequence:
MKSALCIALALTWSLLVQAARQTVLAVADHDIGGYSTFLQSLTDRDFDVKTSYIKDESAKLFEYGERLYDNLILLSSQSKSLGPVFSPKSLLEFVQSGGNLFVVAGSQLPEGIRELGRQLDMFLAERQSVVVDHFNHAEGSDDIILLDGISENPYIISDETRAAGPILYKGIGHYLGPNPQTQPILRGNPTSYIYNTKTEAEVSKNPWAAGTQLFLVSVLQSSTGERVGLSGSIDMLKDEYLSPQSPSFSKSNFLFARDLTNWVFQRKGVLQATNMTYGKVAEPLESRNASCYRIKDEMIFSIDISLLEDGQQTPYVADDVQLELIMLDPYYRVNLVPVPSDSQTSQHYEAVLVAPDHYGDFTFKIEYKRPGLTPIEEKSTFTLRQFFHNEFPRFLPHAYPYYASCFSVLGAFLLFCGIWLLQKPAKPVVPSAKKQN
Protein: Sodium/potassium-transporting ATPase subunit beta-2 (Protein nervana 2) (Sodium/potassium-dependent ATPase subunit beta-2) (Q24048)
Organism: Drosophila melanogaster (Fruit fly)
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit alpha
- Multidrug resistance protein homolog 65
- Sodium/potassium-transporting ATPase subunit beta-1
- Neurexin-4
- Neuroglian
- Sodium/potassium-transporting ATPase subunit alpha
- GH05443p
- Uncharacterized protein, isoform A
- G-protein coupled receptor moody
- Lachesin
Sequence:
MPTITEDCIDGFQQYYSRPPERPKKKSLKQMVYDSEDNSYFGRSMDSWAKIGIFYVAFYGVLAALVAICMWAFFQTLDPRIPKWTLDRSLIGTNPGLGFRPLPPVDNVESTLIWYKGTQHENYKHWTDSLDDFLAVYKVPGLTPGRGQNIYNCDYNQPPPKGQVCDVDIKTWSPCTKENNYSYHKSAPCIFLKLNKIYGWIPEYYNRSNDLPANMPASLKTYIAEVEKTQPEKLNTIWVSCEGENPADQENIGAVNYLPIRGFPGYFYPYQNSEGYLSPLVAVHFQRPKRGIIINVECRAWARNIIHDRKERIGSVHYELLID
Protein: Aldehyde-alcohol dehydrogenase 2 [Includes: Alcohol dehydrogenase (ADH) (EC 1.1.1.1); Acetaldehyde dehydrogenase (ACDH) (EC 1.2.1.10)] (Q24803)
Organism: Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)
Function: This enzyme has two NAD(+)-dependent activities: ADH and ACDH. May be a critical enzyme in the fermentative pathway.
Interaction partners:
Sequence:
MSTQQTMTVDEHINQLVAKAQVALKEYLKPEYTQEKIDYIVKKASVAALDQHCALAAAAVEETGRGIFEDKATKNIFACEHVTHEMRHAKTVGIINVDPLYGITEIAEPVGVVCGVTPVTNPTSTAIFKSLISIKTRNPIVFSFHPSALKCSIMAAKIVRDAAISAGAPENCIQWIEFGGIEASNKLMNHPGVATILATGGNAMVKAAYSSGKPALGVGAGNVPTYIEKTCNIKQAANDVVMSKSFDNGMICASEQAAIIDKEIYDQVVEEMKTLGAYFINEEEKAKLEKFMFGVNAYSADVNNARLNPKCPGMSPQWFAEQVGIKVPEDCNIICAVCKEVGPNEPLTREKLSPVLAILKAENTQDGIDKAEAMVEFNGRGHSAAIHSNDKAVVEKYALTMKACRILHNTPSSQGGIGSIYNYIWPSFTLGCGSYGGNSVSANVTYHNLLNIKRLADRRNNLQWFRVPPKIFFEPHSIRYLAELKELSKIFIVSDRMMYKLGYVDRVMDVLKRRSNEVEIEIFIDVEPDPSIQTVQKGLAVMNTFGPDNIIAIGGGSAMDAAKIMWLLYEHPEADFFAMKQKFIDLRKRAFKFPTMGKKARLICIPTTSGTGSEVTPFAVISDHETGKKYPLADYSLTPSVAIVDPMFTMSLPKRAIADTGLDVLVHATEAYVSVMANEYTDGLAREAVKLVFENLLKSYNGDLEAREKMHNAATIAGMAFASAFLGMDHSMAHKVGAAFHLPHGRCVAVLLPHVIRYNGQKPRKLAMWPKYNFYKADQRYMELAQMVGLKCNTPAEGVEAFAKACEELMKATETITGFKQANIDEAAWMSKVPEMALLAFEDQCSPANPRVPMVKDMEKILKAAYYPIA
Protein: Trypsin-4 (EC 3.4.21.4) (Q9R0T7)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space {ECO:0000305}.
Interaction partners:
- Chymotrypsinogen B
- Anionic trypsin-2
- Collagenase 3
- Proteinase-activated receptor 2
- Plasminogen
- Serine protease inhibitor Kazal-type 1
- Carboxypeptidase A1
- Amyloid-beta precursor protein
- Chymopasin
- Proteinase-activated receptor 1
Sequence:
MRALLFLALVGAAVAFPVDDDDKIVGGYTCRENSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKSRIQVRLGEHNINVLEGNEQFVNSAKIIKHPNFNSRTLNNDIMLIKLASPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVNNPDLLQCLDAPLLPQADCEASYPGKITNNMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGYGCALKDNPGVYTKVCNYVDWIQNTIAAN
Protein: Interferon lambda-3 (IFN-lambda-3) (Interleukin-28B) (IL-28B) (Q8CGK6)
Organism: Mus musculus (Mouse)
Function: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Interferon lambda receptor 1
- Interleukin-10 receptor subunit beta
- Interferon lambda-2
- Interferon alpha/beta receptor 1
- Interferon gamma receptor 1
- Interleukin-20 receptor subunit alpha
- Interferon alpha/beta receptor 2
- Interleukin-10 receptor subunit alpha
- Interleukin-6 receptor subunit alpha
- Interleukin 20 receptor beta
Sequence:
MLLLLLPLLLAAVLTRTQADPVPRATRLPVEAKDCHIAQFKSLSPKELQAFKKAKGAIEKRLLEKDMRCSSHLISRAWDLKQLQVQERPKALQAEVALTLKVWENINDSALTTILGQPLHTLSHIHSQLQTCTQLQATAEPKPPSRRLSRWLHRLQEAQSKETPGCLEDSVTSNLFQLLLRDLKCVASGDQCV