wanglab/gogpt-training-data huggingface dataset:
Protein: Macrophage galactose N-acetyl-galactosamine specific lectin 2 (F6QSC4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
NFQNLEREEKNQEMRNGDKKGGMESPKFALIPSQSFLWRILSWTHLLLFSLGLSLLLLVVISVIGSQNSQLRRDLGTLRAILDNTTSKIKAEFQSLDSRADNFEKGISSLKVDVEDHRQELQAGRDLSQKVTSLESTLEKREQALKTDLSDLTDHVQQLETDLKALTCQLANLKNNGSEVACCPLHWTEHEGSCYWFSESEKSWPEADKYCRLENSHLVVVNSLEEQNFLQNRLANVLSWMGLTDQNGPWRWVDGTDFDKGFKYVCRLQLAPLYLGLSYLFSIFSDPRDLGGPSGNMADGQIWSAQFFIFRNWRPLQPDNWHGHMLGGGEDCAHFSYDGRWNDDVCQRHYHWICETELGKASSAHSPQLIASVP
Protein: DENN domain-containing protein 2D (Q9H6A0)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23182661}.
Interaction partners:
- RNA polymerase II elongation factor ELL
Sequence:
MEGQVVGRVFRLFQRRLLQLRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQKKPREKTVK
Protein: CW14 protein (T30E16.22) (Q9SLT5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein PHLOEM PROTEIN 2-LIKE A2
- Ethylene-regulated transcript 2
Sequence:
MGGCVSTPKSCVGGKIRSSKRRKTRTRRKIQKKRVVSSSRLSDGSFDNNPTFRASVDEAWFDSNLAFETDCDDDFHSVQEDTLSVNGCERISVSSMSSVKDSNLGGSARNSLSDVISQSKSESALIDTKQAVFIDEISSNADGSSNKDEGLLENCGILPSNCLPCLNSTVPSIEKRRSLSSSPPSTRKKAAVKLSFKWREGHPTGPLFSTTMQLQRPMAGSQVPFCPLEKKMFDSWSIIEPGSFRVRSKTYFRDKKKELAPNYAAYNPFGVDVFLSQRKVNHIAQYVELPVVTTTPTKLPSILVVNVQIPLYPAAIFHGETDGEGMNFVLYFKLSDNYLKELPPHFQESIQRLLDDEVEKVRGYTTDTNVPFRERLKILGRVANVDDLQLNGAEKKLMNAYNEKPVLSRPQHEFYSGENYFEIDIDMHRFSYISRKGFEAFLDRLKNCVLDVGLTIQGNKPEELPEQILCCIRLNGIDYMNYHQLALSQEVL
Protein: Protein zerknuellt 1 (ZEN-1) (P09089)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:2892759}.
Interaction partners:
- Protein twist
- Protein decapentaplegic
- Transcription factor Zelda
Sequence:
MSSVMHYYPVHQAKVGSYSADPSEVKYSDLIYGHHHDVNPIGLPPNYNQMNSNPTTLNDHCSPQHVHQQHVSSDENLPSQPNHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMSYSQDPREGTAAAEKRPMMAVAPVNPKPDYQASQKMKTEASTNNGMCSSADLSEILEHLAQTTAAPQVSTATSSTGTSTNSASSSSSGHYSYNVDLVLQSIKQDLEAAAQAWSKSKSAPILATQSWHPSSQSQVPTSVHAAPSMNLSWGEPAAKSRKLSVNHMNPCVTSYNYPN
Protein: Centriole, cilia and spindle-associated protein (Q6P3G4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in embryonic development, including proper left-right asymmetry formation. Also required for proper cilia beating. Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6IQ19}. Cell projection, axon {ECO:0000250|UniProtKB:Q6IQ19}. Cell projection, cilium {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6IQ19}. Note=Localizes at specific foci at the apical surface of neuroepithelial cells where cilia form along the brain ventricle lumen. {ECO:0000269|PubMed:22493317}.
Interaction partners:
- Centrosomal protein 120.
- Centrosomal protein of 135 kDa
Sequence:
MVTKRIRSEYMKKFKDPKWDTYAKCYEDLLKYRLSRRLLEQAHKPWFWGEWGSETASSGKSTPLSRNKVEPLKTLDEKPERSACVTPEPAAEAETQAAEVQDREHADTNLVPCDAEVAHPEGEEVRGKERSPAVNPDSDTQIQNMSKSKRRSSHKYTRSKVKPQAPKDPDKENRHPFALYGAGEKQTDMASKKTHNVGPAASTAEIHESALRAKTRREVEKQIKRFDKQRARSADLEKSRNKIIPDFNPWMTEYMRCFSARSR
Protein: Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme (PPIase) (EC 5.2.1.8) (Rotamase) (P15425)
Organism: Drosophila melanogaster (Fruit fly)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction.
Subcellular location: Membrane {ECO:0000269|PubMed:1707759}; Single-pass membrane protein {ECO:0000269|PubMed:1707759}.
Interaction partners:
- Calphotin
- LD47550p
- rRNA 2'-O-methyltransferase fibrillarin
- rRNA 2'-O-methyltransferase fibrillarin
- Opsin Rh1
- NADH-ubiquinone oxidoreductase chain 4
- Neither inactivation nor afterpotential protein G
- Inactivation-no-after-potential D protein
- LD47749p
- RNA cytidine acetyltransferase
Sequence:
MKSLLNRIILCSAFLAVASGLSFTVTSRIYMDVKHNKKPVGRITFGLFGKLAPKTVANFRHICLRGINGTSYVGSRFHRVVDRFLVQGGDIVNGDGTGSISIYGDYFPDEDKALAVEHNRPGYLGMANRGPDTNGCQFYVTTVGAKWLDGKHTVFGKVLEGMDTIYAIEDVKTDTDDFPVEPVVISNCGEIPTEQFEFYPDDFNILGWIKAAGLPVTSSFCVLLIFHYFFRQLNMYC
Protein: Prefoldin subunit beta (GimC subunit beta) (O58268)
Organism: Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Function: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Prefoldin subunit alpha
- Uncharacterized protein PH0533
- Phosphoesterase
- CpXC domain-containing protein
- DNA-directed RNA polymerase subunit Rpo12
- tRNA-binding domain-containing protein
- Thermosome subunit
- Cupin type-2 domain-containing protein
- Peroxiredoxin
Sequence:
MQNIPPQVQAMLGQLDTYQQQLQLVIQQKQKVQADLNEAKKALEEIETLPDDAQIYKTVGTLIVKTTKEKAVQELKEKIETLEVRLNALNRQEQKINEKVKELTQKIQAALRPPTAG
Protein: Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) (P58876)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H2A type 1-C
- Histone H4
- Histone H3.2
- Histone H3-like centromeric protein A
- Histone H2A type 1-D
- Histone H2A.J
- Histone H2B type 1-H
- Histone H2A type 1-B/E
- Histone H2A type 2-A
- Histone H2B type 1-C/E/F/G/I
Sequence:
MPEPTKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Protein: Pentatricopeptide repeat-containing protein At1g62910 (Q9LQ16)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein arginine N-methyltransferase 1.6
- mRNA guanylyltransferase
- 14-3-3-like protein GF14 psi
Sequence:
MQRSISLTAKRLFVHWNLQGIGNPPTVPSFFNLCGSGCWERSFASASGDYREILRNRLSDIIKVDDAVDLFGDMVKSRPFPSIVEFNKLLSAVAKMNKFELVISLGEQMQTLGISHDLYTYSIFINCFCRRSQLSLALAVLAKMMKLGYEPDIVTLSSLLNGYCHSKRISDAVALVDQMVEMGYKPDTFTFTTLIHGLFLHNKASEAVALVDQMVQRGCQPDLVTYGTVVNGLCKRGDIDLALSLLKKMEKGKIEADVVIYNTIIDGLCKYKHMDDALNLFTEMDNKGIRPDVFTYSSLISCLCNYGRWSDASRLLSDMIERKINPNVVTFSALIDAFVKEGKLVEAEKLYDEMIKRSIDPDIFTYSSLINGFCMHDRLDEAKHMFELMISKDCFPNVVTYSTLIKGFCKAKRVEEGMELFREMSQRGLVGNTVTYTTLIHGFFQARDCDNAQMVFKQMVSVGVHPNILTYNILLDGLCKNGKLAKAMVVFEYLQRSTMEPDIYTYNIMIEGMCKAGKVEDGWELFCNLSLKGVSPNVIAYNTMISGFCRKGSKEEADSLLKKMKEDGPLPNSGTYNTLIRARLRDGDREASAELIKEMRSCGFAGDASTIGLVTNMLHDGRLDKSFLDMLS
Protein: Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit) (Q9ULK0)
Organism: Homo sapiens (Human)
Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Subcellular location: Postsynaptic cell membrane {ECO:0000305|PubMed:38060673}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
Sequence:
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIELSALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSATMPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI
Protein: Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNaseY) (Deoxyribonuclease I-like 3) (DNase I-like 3) (O89107)
Organism: Rattus norvegicus (Rat)
Function: Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (By similarity). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:9665719}. Secreted {ECO:0000250|UniProtKB:O55070, ECO:0000250|UniProtKB:Q13609}. Note=May first pass through the ER membrane before being imported in the nucleus. Contradictory reports exist about the subcellular localization under normal physiological conditions. Under conditions of cell death, may diffuse and/or be actively transported to the nucleus (By similarity). {ECO:0000250|UniProtKB:O55070, ECO:0000305}.
Interaction partners:
- Deoxyribonuclease-2-alpha
Sequence:
MSLYPASPYLASLLLFILALHGALSLRLCSFNVRSFGESKKENHNAMDIIVKIIKRCDLILLMEIKDSNNNICPMLMEKLNGNSRRSTTYNYVISSRLGRNTYKEQYAFLYKEKLVSVKAKYLYHDYQDGDTDVFSREPFVVWFQAPFTAAKDFVIVPLHTTPETSVKEIDELADVYTDVRRRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPNFVWLIGDQEDTTVKKSTSCAYDRIVLRGQEIVNSVVPRSSGVFDFQKAYELSEEEALDVSDHFPVEFKLQSSRAFTNSRKSVSLKKKKKGSRS
Protein: Pyridoxal-phosphate-dependent serine hydroxymethyltransferase, putative (DUF632) (F4J3B3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGCCQSRIDSKEIVSRCKARKRYLKHLVKARQTLSVSHALYLRSLRAVGSSLVHFSSKETPLHLHHNPPSPSPPPPPPPRPPPPPLSPGSETTTWTTTTTSSVLPPPPPPPPPPPPPSSTWDFWDPFIPPPPSSSEEEWEEETTTATRTATGTGSDAAVTTAPTTATPQASSVVSGFSKDTMTTTTTGSELAVVVSRNGKDLMEIIKEVDEYFLKAADSGAPLSSLLEISTSITDFSGHSKSGKMYSSSNYECNLNPTSFWTRGFAPSKLSEYRNAGGVIGGNCIVGSHSSTVDRLYAWEKKLYQEVKYAESIKMDHEKKVEQVRRLEMKRAEYVKTEKAKKDVEKLESQLSVSSQAIQSASNEIIKLRETELYPQLVELVKGSMYESHQVQTHIVQQLKYLNTIPSTEPTSELHRQSTLQLELEVQQWHHSFCNLVKAQRDYIQSLTGWLRLSLFQFSKNPLVRSSYESKIYSFCEEWHLAIDRIPDKVASEGIKSFLTAVHGIVAQQADEHKQKKRTESMLKDFEKKSASLRALESKYSPYSVPESRKKNPVIEKRVKVEMLKGKAEEEKSKHEKSVSVTRAMTLNNLQMGFPHVFQAMVGFSSVCMQAFESVYNQAKSIGEDQEEVKRLLP
Protein: High-affinity choline transporter 1 (O02228)
Organism: Caenorhabditis elegans
Function: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Vesicular acetylcholine transporter unc-17
- Proline dehydrogenase 1, mitochondrial
- Choline O-acetyltransferase
- Transcription factor unc-3
- LIM/homeobox protein lim-6
- Probable vesicular glutamate transporter eat-4
- Probable delta-1-pyrroline-5-carboxylate synthase
- GLutamate Receptor family
- Soluble guanylate cyclase gcy-33
Sequence:
MADLLGIVAIVFFYVLILVVGIWAGRKSKSSKELESEAGAATEEVMLAGRNIGTLVGIFTMTATWVGGAYINGTAEALYNGGLLGCQAPVGYAISLVMGGLLFAKKMREEGYITMLDPFQHKYGQRIGGLMYVPALLGETFWTAAILSALGATLSVILGIDMNASVTLSACIAVFYTFTGGYYAVAYTDVVQLFCIFVGLWVCVPAAMVHDGAKDISRNAGDWIGEIGGFKETSLWIDCMLLLVFGGIPWQVYFQRVLSSKTAHGAQTLSFVAGVGCILMAIPPALIGAIARNTDWRMTDYSPWNNGTKVESIPPDKRNMVVPLVFQYLTPRWVAFIGLGAVSAAVMSSADSSVLSAASMFAHNIWKLTIRPHASEKEVIIVMRIAIICVGIMATIMALTIQSIYGLWYLCADLVYVILFPQLLCVVYMPRSNTYGSLAGYAVGLVLRLIGGEPLVSLPAFFHYPMYTDGVQYFPFRTTAMLSSMATIYIVSIQSEKLFKSGRLSPEWDVMGCVVNIPIDHVPLPSDVSFAVSSETLNMKAPNGTPAPVHPNQQPSDENTLLHPYSDQSYYSTNSN
Protein: P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor) (P49650)
Organism: Mus musculus (Mouse)
Function: Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P47900}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47900}.
Interaction partners:
- Guanine nucleotide-binding protein G
- P2X purinoceptor 1
- P2X purinoceptor 7
- Prothrombin
- P2X purinoceptor 4
- P2X purinoceptor 2
- Adenosine receptor A2a
- P2X purinoceptor 3
- P2X purinoceptor
- Adenosine receptor A1
Sequence:
MTEVPWSVVPNGTDAAFLAGLGSLWGNSTVASTAAVSSSFQCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGTRKNKTVTCYDTTSNDYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVKALIYNDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL
Protein: ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (H3BM52)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120, ECO:0000256|RuleBase:RU367099}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300, ECO:0000256|RuleBase:RU367099}. Cytoplasm {ECO:0000256|RuleBase:RU367099}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367099}. Mitochondrion intermembrane space {ECO:0000256|RuleBase:RU367099}.
Interaction partners:
Sequence:
XLEGESFALSFSSASDAEFDAVVGYLEDIIMDDEFQLLQRNFMDKYYLEFEDTEENKLIYTPIFNEYISLVEKYIEEQLLQRIPEFNMAAFTTTLQHHKDEVAGDIFDMLLTFTDFLAFKEMFLDYRALPRTICGTRSYLQPMNGIILDVTSPIGSAHDDRTHLGKTDSVM
Protein: Protein transport protein SEC23 D (AtSEC23D) (Protein transport protein SEC23/SEC24-like 1) (AtSec23/Sec24L1) (Protein transport protein SEC24 D) (Q9ZQH3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (By similarity). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). May contribute to COPII-coated vesicles formation and ER-Golgi vesicle transport. Together with SEC23A, essential for pollen wall development and exine patterning, probably by regulating endoplasmic reticulum (ER) export of lipids and proteins (e.g. sporopollenin) necessary for pollen wall formation. Also involved in plastid physiology in anther tapetal cells.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:29390074}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15303}; Cytoplasmic side {ECO:0000250|UniProtKB:P15303}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:29390074}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15303}; Cytoplasmic side {ECO:0000250|UniProtKB:P15303}. Membrane {ECO:0000250|UniProtKB:P15303}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15303}; Cytoplasmic side {ECO:0000250|UniProtKB:P15303}. Note=Observed at endoplasmic reticulum exit sites (ERESs), characteristic for COPII-coated vesicles localization. {ECO:0000269|PubMed:29390074}.
Interaction partners:
- Protein transport protein SEC13 homolog B
- Protein transport protein SEC31 homolog B
- Protein transport protein SEC31 homolog A
- Protein transport protein SEC13 homolog A
- Protein transport protein SEC16B homolog
- Protein transport protein SEC16A homolog
- small monomeric GTPase
- Protein transport protein SEC24 C
- Protein transport protein SEC24 B
- Protein transport protein SEC23 B
Sequence:
MAVRATVSRFPIDSDAQEASGLPWGLTVTPFAAKDENGIGPACGSNGHLLPRCENCYAYFNTYCELDQWAWNCSLCGTLNGLPSDAIARYSNPHSIPEMTSSFIDLEMPLDGSEEEMTQARPVYVAAIDISSSEEFLELTKSALLAALEALSPGALFGLVTFSHKIGLYDVQGPIPVVKNVFIPPDGESSLSLELEDVMPLLQFLAPVETCKDRIAAALETLRPITSWERSAGAGQGMDSVLMGGRGFGTAMEALFNYLGSEFGNTFALARVFAFLSGPPDYGRGQLDTSRYGEQYASKRVDADRALLPEQTPFYKDLATIAVQSGVCVDLFAVTNEYTDLASLKFLSIESGGSLFLYSSTDDSTLPQDMFRMLNRPYAFNCVLRLRTSTEFKPGNSFGHFFPDPQYENLQHIICCDSYATYAYDFEFADNTGFSRHSGEQPVVQIAFQYTVVVPPEGLSNSEMSSSSRGKHTLQRRLRIRTMQFGTAHNINEIYDSVDHEVVLSLLVHKVILASLEDGVREGRALLHDWLVILTAQYNDAFNLVQYKNGNKSMSSQIDITFSQCPQLEPLPRLVFALLRNPLLRFHEEGVHPDYRIYLQCLFSVLDPSSLHCGIYPALMSYSTPDTLAYPRHSLSRAALITSGSPIFFLDAYTTLIVFYSSTADPSIPFPPPQDCLLRQTINKVKQERSITPKLVFIRGGRDDATVFENYLIEEQDVDGNGFASAMGFVSFLDDISQRVTEYMK
Protein: LysM and putative peptidoglycan-binding domain-containing protein 1 (Q96S90)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASPSRQPPPGGSGLLQGSRARSYGSLVQSACSPVRERRLEHQLEPGDTLAGLALKYGVTMEQIKRANRLYTNDSIFLKKTLYIPILTEPRDLFNGLDSEEEKDGEEKVHPSNSEVWPHSTERKKQETGAGRANGEVLPTPGQETPTPIHDLSASDFLKKLDSQISLSKKAAAQKLKKGENGVPGEDAGLHLSSPWMQQRAVLGPVPLTRTSRTRTLRDQEDEIFKL
Protein: Thrombin-like enzyme elegaxobin-2 (SVTLE) (EC 3.4.21.-) (Elegaxobin II) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (P84787)
Organism: Protobothrops elegans (Elegant pitviper) (Trimeresurus elegans)
Function: Thrombin-like snake venom serine protease that clots rabbit fibrinogen. Only the beta chain of fibrinogen (FGB) is cleaved, releasing fibrinopeptide B. Human and bovine fibrinogen are unaffected. Also cleaves Met-Lys and Arg-Ser bonds in heat-denatured bovine plasma kininogen to release Lys-bradykinin.
Subcellular location: Secreted {ECO:0000269|PubMed:12676434, ECO:0000269|PubMed:15500847}.
Interaction partners:
Sequence:
VIGGDECNINEHPFLVLVYYDEYQCGGTLINEEWVLTAAHCDGENMEIHLGMHSKKVPNKDRRRRVPKEKFFCDSSKNYTKWNKDIMLIRLNRPVRKSAHIAPLSLPSSPPSVGSVCRIMGWGTISPTEETYPDVPHCANINLLDYEVCRAAYPELPATSRTLCAGILEGGKDSCGGDSGGPLICNGQFQGIVSWGGDPCAQPHEPGSYTNVFDHLDWIKGIIAGNTDATCPL
Protein: Fcy2p (A0A1D8PJQ2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- uracil phosphoribosyltransferase
- Cytosine deaminase.
Sequence:
MTENYDLEQQETQAPENQVNVEKILLDKSNVDEDPITSTIEQSSTSNSSLKKPTNWVDKIGLRINAEIRGIERVPESERHDNSLLSPFLVFLSPNMVISGLSIGSLGPVAYNLDFRTSIIIITIFCIIGSIPVGFFSAFGMRFGIRQQILSRYFTGNIMGRIFALFNVISCIGWNAVNVIPCAQLLNSVGPLPPWAGCLILVGCTCIFAVFGYKTVHLYEKYSWIPNFIVFMIIIAKFSQTHAFNWGEKKSGPTEAGNVLNFISAIFGFTVGWIPSSADYTVYMPANTNPWKVAFAMTTGLSLPAMFTAILGAAIGTSVNLKGSRFEQAYNKNSTGGLIYEILCGDNNNQGYRFIIVVFALGAIANGIPGSYSLSLAIQCIWSQCARVPRIAWCILGNLVALAFSISAYYKFQDTMSNFLSIIAYNVSIYLSISLTEHFIYRRGFSGYDVTDFNNYKTMPVGIAGVVAFCFGICSTVLSMNQTWYQGVIARKIGDNGGDISFEMNIMFAFIGYNLVRPFELKYFGR
Protein: Ectodysplasin A receptor (Tumor necrosis factor receptor superfamily member EDAR precursor) (A0A0R4IGE7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Ectodysplasin A
- Ectodysplasin-A receptor-associated adapter protein
- Paired box protein Pax-9
- Sodium/potassium/calcium exchanger 5
- Lymphoid enhancer-binding factor 1
Sequence:
MGHKGGRTPSFLLHFLLVSSMSTVSAEYSSCGENEFYNHTTSSCQPCPQCQAGQEPYMNCGYGTKDDDYSCVSCPAGKFSKGKYEICRRHKDCDALYRATVLTPGTSDSDAECGHCLPGYYIQENRPQNIYGMVCHSCQNAPRNIKECMRSTPPASGRAPSVSSSSTTIFPQPEKDPTGQGHLATALIIAMSTIFIMAIAIVMIIMFYILKSKPSGPVCCSGQLIKAVEAQTNMQEEKKEAQENVVIFQEKDEFDKLKPSSPKTAKSENDASSENEQLLSRSIDSDEEAAQDKQGAADLCLLSLVHLTRDKSCTTNTINNNNNNHCSRATGIHSRRKKILDLYTKACSVAEGLSPTELPFDCLERSSRMLSATYSTDKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPDLLARLLQIERLDAVETLCCDILSGTQNCTNPPLSSRCASV
Protein: Small ubiquitin-related modifier 3-like (SUMO-3-A) (Q6NV25)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
Interaction partners:
- SUMO-conjugating enzyme UBC9-A
- Si:ch1073-55a19.2.
- SUMO-conjugating enzyme UBC9-B
- SUMO-activating enzyme subunit 1
- SUMO-activating enzyme subunit 2
- FinTRIM family, member 52, pseudogene.
- Proliferating cell nuclear antigen
- RING finger protein 4
- Ubiquitin-like protein NEDD8
- NEDD8 ubiquitin-like modifier, like.
Sequence:
MSEDKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSIRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGSC
Protein: Transcription factor IIIA (A0A1X7SBT5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
LDPPAVVAESVSSLTIADAFIAAGESSAPTPPRPALPRRFICSFPDCSANYSKAWKLDAHLCKHTGERPFVCDYEGCGKAFIRDYHLSRHILTHTGEKPFVCAANGCDQKFNTKSNLKKHFERKHENQQKQYICSFEDCKKTFKKHQQLKIHQCQHTNEPLFKCTQEGCGKHFASPSKLKRHAKAHEGYVCQKGCSFVAKTWTELLKHVRETHKEEILCEVCRKTFKRKDYLKQHMKTHAPERDVCRCPREGCGRTYTTVFNLQSHILSFHEESRPFVCEHAGCGKTFAMKQSLTRHAVVHDPDKKKMKLKVKKSREKRSLASHLSGYIPPKRKQGQGLSLCQNGESPNCVEDKMLSTVAVLTLG
Protein: Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) (Q6TYB5)
Organism: Mus musculus (Mouse)
Function: Involved in axonal outgrowth and fasciculation.
Interaction partners:
- Short coiled-coil protein
Sequence:
MAADGDWQDFYEFQEPAGSVQEQENCNASPEAGAGAHAGGDSFPALASSLEEKLSLCFRPTSEAEPPRAAVRPITECSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLSEKGMNDGLLFDASDEEELREQLDMHSIIVSCVNEEPLFTADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSSMSSYEERVKRLSVSELNELLEEIEAAIKQYSEELVQQLALRDELEFEKEVENSFISALIEVQNKQKEHKETAKKKKKLKSGSSQNGRSERSHMPGTYLTTVIPYEKKSGPPSVEDLQILTKILHAMKEDSEKVPSLLTDYILKVLCPT