wanglab/gogpt-training-data huggingface dataset:
Protein: Solute carrier family 9 (sodium/hydrogen exchanger), member 6 (D3Z0Q9)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004195}.
Interaction partners:
Sequence:
MDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYTLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLF
Protein: tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) (P15565)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs.
Subcellular location: [Isoform 1]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Predominantly targeted to the nucleus.
Interaction partners:
- Multisite-specific tRNA:
- tRNA
- tRNA
- tRNA pseudouridine synthase 4
- tRNA-dihydrouridine
- tRNA
- tRNA acetyltransferase TAN1
- tRNA
- tRNA
- tRNA dimethylallyltransferase
Sequence:
MEGFFRIPLKRANLHGMLKAAISKIKANFTAYGAPRINIEDFNIVKEGKAEILFPKKETVFYNPIQQFNRDLSVTCIKAWDNLYGEECGQKRNNKKSKKKRCAETNDDSSKRQKMGNGSPKEAVGNSNRNEPYINILEALSATGLRAIRYAHEIPHVREVIANDLLPEAVESIKRNVEYNSVENIVKPNLDDANVLMYRNKATNNKFHVIDLDPYGTVTPFVDAAIQSIEEGGLMLVTCTDLSVLAGNGYPEKCFALYGGANMVSHESTHESALRLVLNLLKQTAAKYKKTVEPLLSLSIDFYVRVFVKVKTSPIEVKNVMSSTMTTYHCSRCGSYHNQPLGRISQREGRNNKTFTKYSVAQGPPVDTKCKFCEGTYHLAGPMYAGPLHNKEFIEEVLRINKEEHRDQDDTYGTRKRIEGMLSLAKNELSDSPFYFSPNHIASVIKLQVPPLKKVVAGLGSLGFECSLTHAQPSSLKTNAPWDAIWYVMQKCDDEKKDLSKMNPNTTGYKILSAMPGWLSGTVKSEYDSKLSFAPNEQSGNIEKLRKLKIVRYQENPTKNWGPKARPNTS
Protein: Larval serum protein 1 alpha chain (Hexamerin-1-alpha) (P11995)
Organism: Drosophila melanogaster (Fruit fly)
Function: Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:3097321}.
Interaction partners:
- Larval serum protein 1 beta chain
- Larval serum protein 1 gamma chain
- Larval serum protein 2
- General odorant-binding protein 99b
- Fat body protein 2
- Fat-body protein 1
Sequence:
MKFAIAFLACVAVVTATAYHKTHDIKVADKAFLMKQKFLFEIVYRVEDPLMFEEYIAMGKQFYFDKEHYTHFDLYMEKFFEAHKAHALLPKGEFFGALVKHHAKQARGLFNFFYYAKDWETFMTNVAFARMHFNEGMFVYALTLAVIHRDDFHGLVLPAIHEIFPQFFFNSKFVMEAEKFDYEMWMKTSLYEKEYMDVYHKIPTFSSYEHGYKQGMAYGYGKTHGHGQTYEHEFGSMYQTSDYMYMKDFKTWQWWKLMGLGEHWYSESNYILRENIYEYNQESNWLTMMKDVKKFYMPVDYSRDLYLYNEESKLSYFTEDLGWNSYWYYLNMDYSFFLDGKTFGLQNDRRGEWWLYNVHQLLSRYHMERLSHGLGEIPQFSWFHQIEMGYDPQLIYYNGIGYSYRKNYYELETYGNFEMLDKITGFQQRIQNIVELGYYQTTDGHMIDLRKPESIEIIGNMLQGNVDAIDNIFFQFWYMLAHMYFADTHYYQMEVYPNVMLNFETMMRDPMFYMFYKSIAQVYFQFMHHLPKYTKEQLLMPGVTLKHVEVSELVTYFDLVDFDVTNMLNGKMVFHEGQFLWDKSLFARQMRLNHKPFSYTYTIDSARDEKVVIRAFLGPKFDEYGRMISLTDNRMNFMEIDEFTYTLKTGSNLITRKSTDFAWTVKDRTTYTELYYYTMMAFDGKYDYPLDLTEPHCGFPDRLVLPMGWKKGMPMQMFFMVVPYMAPQHEQFSTFDYTYSCGIGSGARHVDSLPFGYPFDREINEYEFHVPNMYFKDVTIYHADTMEKYYNYKEYTNYGHFDYSFFNDYYTKYFKL
Protein: E3 ubiquitin-protein ligase ARK2C (EC 2.3.2.27) (RING finger protein 165) (RNF165) (Q6ZSG1)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:E9QAU8}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 D2
- Ubiquitin-ribosomal protein eL40 fusion protein
- Polyubiquitin-C
Sequence:
MVLVHVGYLVLPVFGSVRNRGAPFQRSQHPHATSCRHFHLGPPQPQQLAPDFPLAHPVQSQPGLSAHMAPAHQHSGALHQSLTPLPTLQFQDVTGPSFLPQALHQQYLLQQQLLEAQHRRLVSHPRRSQERVSVHPHRLHPSFDFGQLQTPQPRYLAEGTDWDLSVDAGLSPAQFQVRPIPQHYQHYLATPRMHHFPRNSSSTQMVVHEIRNYPYPQLHFLALQGLNPSRHTSAVRESYEELLQLEDRLGNVTRGAVQNTIERFTFPHKYKKRRPQDGKGKKDEGEESDTDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICRVDIETQLGADS
Protein: Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) (Q16584)
Organism: Homo sapiens (Human)
Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12529434}. Note=Location is cell cycle dependent.
Interaction partners:
- Cell division control protein 42 homolog
- C-Jun-amino-terminal kinase-interacting protein 1
- Dual specificity mitogen-activated protein kinase kinase 7
- C-Jun-amino-terminal kinase-interacting protein 2
- C-Jun-amino-terminal kinase-interacting protein 3
- Mitogen-activated protein kinase kinase kinase kinase 1
- Dual specificity mitogen-activated protein kinase kinase 4
- Fos-related antigen 1
- Glutamate receptor ionotropic, kainate 2
- Ferritin heavy chain
Sequence:
MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP
Protein: carbonyl reductase (NADPH) (EC 1.1.1.184) (Q9PT38)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MSKKVAVVTGANKGIGLAIVRELCKAKFTGDVILTARNEKLGNEAVKMLKSEGFEVSYHHLDICDQGSAKQLSNFLQKTYGGLDVLINNAGMAFKNDATETFGEQAEVTMRTNFWGTLWVCHALLPLLRPNARVVNVSSFVSKKALDTCSPQLQAKFRDTELSEEELCLLMGQFVIAAQQGNHQAQRWPNTAYGTTKIGVTVLSRIQAHYLTKTRAADGILLNACCPGWVRTDMAGSKAPKSPEEGAQTPTYLALLPEGAKEPHGQLVWDKTVQEW
Protein: N-acetylgalactosaminide beta-1,3-galactosyltransferase (EC 2.4.1.122) (O77361)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
Sequence:
MKVGIIFFCLFFFVVLGACNNVKERIFKNIKKRTKFIILNEPIVDLSFSENLFHTLLFDLDVDKNLYTLDESLLNLENLNYSSIFRLLVDTYKNIKENEDDNKNIRYIFLGTSFSRIHPLNFEYFLRKLNKYIYNGNIYEKGNVDIRGILEEYNKEIEEKKLEKQKLNKIKDKNNNNNNNNNSKFSKDGDNEDFNNKNDLYNPSDKLYNNNDDIDVHELLEEIITKEKRFFLNDDDDNDSNDKYILKTDEVNKYKGFFIGYGFNDDIPSVIHHYNFDKNFLFPSLNSGIILDITLLKNIYEVSNILLSNNEKDQSIHIDYIYEVTKYIKENLRVRLTHSENVCLNEEQNIHLLDNDPNNFEIYKYYQVLNLFKDYNKNTEEKQYEKIGHENVRHEETSSEGNENLNRNTKHNNDNNNDNNNYSEDAIAELLLSYFNVFYPISTCMCYSIRSKHESLMDYDKYHMINLENDIKLKHYIKETEEIHFNSIEEYKMKLNRINYKYDTLLEEHENLVTHKNILIGIKTSINTEEERIPHIKNTYDNKENTQIIFNTFNYDNKLKEKNTFGFYNNSLLQNALENDNIDLDIIYMSDKESQKYDNLYFNSKVTSKEGLCEKLKHMIYYYYEEYVMKNSEKKYFFIADDDTFVNVKNLIDVTNLTLNTCSHSKKYMYDKYIKSYDFVKENEALFLQNFPKKTLFLYSYLKDTFAKTIQTLKKYDYVPKYCQGGILSKKHKNNDSDDDHDHHVGNKQNNDSTNHQDIEKNQVNVINNNNNNNNNKAKSIPIYLGRRYSYNTFSTNSNEYFYDYLTGGAGILINDETAKRIYECKECTCPSTNSSMDDMIFGKWAKELGILAINFEGYFQNSPLDYNKKYINTLVPITYHRLNKNRTTKESRDMYFNYLVNYNRNDKEQNKDIYVDYLDRNHKNMIDNVFHYFFYVNMYDEKNKVVTKIEHNADMNSKKNKSKNPQKLNNTQGDKNVNDDENVNDDENVKGDENVKGDENVKGDEYMKGDENVKGDENVKDDENVKDDENIKGDDNNYNVDNMENIDDIINMVESVDDDVMERNKKGTGKEKKDDKNHNNKEKATDVKKSSVPTNNIDKNEDTTKYVIKMNEKIYNRMQESGKYKQLFDINKFFKKEIEGHPYFQKIKKKNEKAKKEKEKMNQLKKQKDYTNNYFHTSNMQGNFNQQKMGNYQNQENEENDFFDQRPEIEEDAINPMDYEEYMENLSNFEDDGEPYDEYDDYDDFVNTINADKLKINDQNKHLYEQIKDIAQPPVNFQNDQNSNTFDFDTDEL
Protein: Regulator of G-protein signaling 2 (RGS2) (Q9JHX0)
Organism: Rattus norvegicus (Rat)
Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P41220}. Cytoplasm {ECO:0000250|UniProtKB:P41220}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P41220}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Adenylate cyclase type 3
- cGMP-dependent protein kinase 2
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha
- Neurabin-2
- Guanine nucleotide-binding protein subunit beta-5
Sequence:
MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQTFIKPSPEEALLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
Protein: Fibroblast growth factor 20 (FGF-20) (Q9EST9)
Organism: Rattus norvegicus (Rat)
Function: Neurotrophic factor that regulates central nervous development and function. May play an important role in dopaminergic neurons in the substantia nigra.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Fibroblast growth factor receptor
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor
- Fibroblast growth factor receptor 4
- Klotho
- Pro-epidermal growth factor
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 3
- Fibroblast growth factor 23
- Platelet-derived growth factor receptor alpha
Sequence:
MAPLTEVGAFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRGALERGARGGPGSVELAHLHGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYLGMNGKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRPVDPERVPELYKDLLVYTG
Protein: histidine kinase (EC 2.7.13.3) (Q9X180)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Interaction partners:
Sequence:
MVPERLKQIKGIRILESEDEIPQEGFTCRFGKHTVVANDEESFEIVRLYKRLTVYELLLSLVDSICVHPKEEALRFSLKKVREFLDAEEVYLIEGDASYSSKGEKLSIDEIKKKHPGASVREWRNKLHLVVVREGAFDEEEEVLCTKLLEFIGNVSEKLWRLKEEVQKLKKSYEEQLKVSEIQKEHIKKMRIIYYVSQAMRSVYDPNNLYRVILLSLVSERGFNFDRAVLLKKDEGTGSLMVVSAVGGDTLQEHEELKRYLRKRTLRYTDLVQFLREEALTFSFETKFNEKIRGKRFYYREHPIFERVVLRKSIVRTSRETLEKIRYEIEDVISILENDEFIVFPLVGRWDTLGVVVVDNKFSKKEVTDLDLDVLKLFSESAGLALENAYNYENLRKKTLDLQRQNELVEHLRNFSESILESLETAIITLSKDGRITEWNKKAEQLFGLKKENVLGRRLKDLPDFEEIGSVAESVFENKEPVFLNFYKFGERYFNIRFSPFRNAKTQLLEGVIITIDDVTELYKYEEERKRRERLSILGEMTARVAHEIRNPITIIGGFIMRMKKHLDDPETLKKYINIITNELSRLETIVKEILEYSKERQVLEFTEFNLNELIREVYVLFEEKIRKMNIDFCFETDNEDLRVEADRTRIKQVLINLVQNAIEATGENGKIKITSEDMYTKVRVSVWNSGPPIPEELKEKIFSPFFTTKTQGTGLGLSICRKIIEDEHGGKIWTENRENGVVFIFEIPKTPEKR
Protein: Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30) (P28908)
Organism: Homo sapiens (Human)
Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:8391931, ECO:0000305|PubMed:8999898}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:8839832}.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 8
- Low affinity immunoglobulin gamma Fc region receptor III-A
- Low affinity immunoglobulin gamma Fc region receptor III-B
- TNF receptor-associated factor 5
- TNF receptor-associated factor 3
- Tumor necrosis factor receptor superfamily member 5
- Tumor necrosis factor receptor superfamily member 4
- CD27 antigen
- TNF receptor-associated factor 1
- Tumor necrosis factor ligand superfamily member 4
Sequence:
MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK
Protein: Gag-Pol polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; Capsid protein p27, alternate cleaved 1; Capsid protein p27, alternate cleaved 2; Spacer peptide (SP) (p3); Nucleocapsid protein p12 (NCp12); Protease p15 (EC 3.4.23.-); Reverse transcriptase beta-subunit (RT-beta); Reverse transcriptase alpha-subunit (RT-alpha) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (pp32); p4] (O92956)
Organism: Rous sarcoma virus subgroup B (strain Schmidt-Ruppin) (RSV-SR-B)
Function: Capsid protein p27: Self-associates to form the irregular polyhedron core composed of hexamers and pentamers, that encapsulates the genomic RNA-nucleocapsid complex. Assembles as a tube in vitro. Binds to inositol hexakisphosphate (IP6), which allows the assembly of the polyhedral capsid.
Subcellular location: [Matrix protein p19]: Virion {ECO:0000250|UniProtKB:P03354}.; SUBCELLULAR LOCATION: [Capsid protein p27, alternate cleaved 1]: Virion {ECO:0000250|UniProtKB:P03354}.; SUBCELLULAR LOCATION: [Capsid protein p27, alternate cleaved 2]: Virion {ECO:0000250|UniProtKB:P03354}.; SUBCELLULAR LOCATION: [Nucleocapsid protein p12]: Virion {ECO:0000250|UniProtKB:P03354}.
Interaction partners:
Sequence:
MEAVIKVISSACKTYCGKTSPSKKEIGAMLSLLQKEGLLMSPSDLYSPGSWDPITAALSQRAMVLGKSGELKTWGLVLGALKAAREEQVTSEQAKFWLGLGGGRVSPPGPECIEKPATERRIDKGEEVGETTVQRDAKMAPEETATPKTVGTSCYHCGTAIGCNCATASAPPPPYVGSGLYPSLAGVGEQQGQGGDTPRGAEQPRAEPGHAGLAPGPALTDWARIREELASTGPPVVAMPVVIKTEGPAWTPLEPKLITRLADTVRTKGLRSPITMAEVEALMSSPLLPHDVTNLMRVILGPAPYALWMDAWGVQLQTVIAAATRDPRHPANGQGRGERTNLDRLKGLADGMVGNPQGQAALLRPGELVAITASALQAFREVARLAEPAGPWADITQGPSESFVDFANRLIKAVEGSDLPPSARAPVIIDCFRQKSQPDIQQLIRAAPSTLTTPGEIIKYVLDRQKIAPLTDQGIAAAMSSAIQPLVMAVVNRERDGQTGSGGRARRLCYTCGSPGHYQAQCPKKRKSGNSRERCQLCDGMGHNAKQCRRRDSNQGQRPGRGLSSGPWPVSEQPAVSLAMTMEHKDRPLVRVILTNTGSHPVKQRSVYITALLDSGADITIISEEDWPTDWPVVDTANPQIHGIGGGIPMRKSRDMIELGVINRDGSLERPLLLFPAVAMVRGSILGRDCLQGLGLRLTNLVGRATVLTVALHLAIPLKWKPDHTPVWIDQWPLPEGKLVALTQLVEKELQLGHIEPSLSCWNTPVFVIRKASGSYRLLHDLRAVNAKLVPFGAVQQGAPVLSALPRGWPLMVLDLKDCFFSIPLAEQDREAFAFTLPSVNNQAPARRFQWKVLPQGMTCSPTICQLVVGQVLEPLRLKHPSLRMLHYMDDLLLAASSHDGLEAAGEEVINTLERAGFTISPDKIQREPGVQYLGYKLGSTYVAPVGLVAEPRIATLWDVQKLVGSLQWLRPALGIPPRLMGPFYEQLRGSDPNEAREWNLDMKMAWREIVQLSTTAALERWDPALPLEGAVVRCEQGAIGVLGQGLSTHPRPCLWLFSTQPTKAFTAWLEVLTLLITKLRASAVRTFGKEVDILLLPACFREDLPLPEGILLALRGFAGKIRSSDTPSIFDIARPLHVSLKVRVTDHPVPGPTVFTDASSSTHKGVVVWREGPRWEIKEIADLGASVQQLEARAVAMALLLWPTTPTNVVTDSAFVAKMLLKMGQEGVPSTAAAFILEDALSQRSAMAAVLHVRSHSEVPGFFTEGNDVADSQATFQAYPLREAKDLHTTLHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGVNPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVAAQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNSQGQAMVERANRLLKDKIRVLAEGDGFMKRIPASKQGELLAKAMYALNHFERGENTKTPVQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVKNRDTDKVIWVPSRKVKPDITQKDEVTKKDEASPLFAGSSDWIPWGDEQEGLQEEAASNKQEGPGEDTLAANES
Protein: Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) (P48437)
Organism: Mus musculus (Mouse)
Function: Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
Subcellular location: Nucleus {ECO:0000269|PubMed:23723244}. Note=RORG promotes its nuclear localization. {ECO:0000269|PubMed:23723244}.
Interaction partners:
- Podoplanin
- Lymphatic vessel endothelial hyaluronic acid receptor 1
- Vascular endothelial growth factor C
Sequence:
MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDVDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQVYDSTDSENDEDGDLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGSNKERDHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGSVQMPSSTDQTEALPLVVRKNSSEQSASGPATGGHHQPLHQSPLSATAGFTTPSFRHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMSDISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
Protein: protein kinase C (EC 2.7.11.13) (Q5ANK2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- GTP-binding protein RHO1
- Mitogen-activated protein kinase kinase kinase
- Serine/threonine-protein kinase PKH2
- non-specific serine/threonine protein kinase
- M-phase inducer phosphatase
- Gag1-like clamp domain-containing protein
- Rho family guanine nucleotide exchange factor
- Rho family GTPase
- Cell division control protein 42 homolog
- Rho family guanine nucleotide exchange factor
Sequence:
MSTSQPSQQQNPEQVVNDIRQKIEKERKIIQGFNDVKRNTNNPEVIQKCKSKIIESQSMIDYYQETMNKLTRQMSRLNTNSSSRTASRSSVISEYKPSYSNFDLIKYECPSLGNKIQFMLQYLEFKLQVENKYSEANKKLSHLYLMDGDKSSSNAAEGGRAESDQRIQLLEKALKKYQKFSINDHEFDRDYEIMDSTKHSRKLLTGRLTVSITCIRDVDHIATALAKKRETVVVIKVDDLEKARTKPSKNDNWNEEMVIDVDKSHEIELAVMDKQNGIYVPVAVNWFSLFDLAEEIRKKKVAKDQGSSGWLPAANLPQTGGSGAGTGSSMTGGASYGATSPLPAHNDLRPSVSPSSDAKENKVSVSTWLSLEPGGQMLINLNFEKSITNGKQFRGPLGRHGAIRQKKEEVFEKHGHQFVQKQFYNIMSCALCGEFLRYTGYQCQDCKFLCHKKCYQKVVTKCISKSGSDYDAAQLNHRIPHRFEPITNHGTKWCCHCGYILPWGKKNVRKCTECGVMCHAQCTHLVPDFCGMSLQMANEILATIESTKVSPKKAQHQQSHAKPLPPKPPIESKPSMDSEETLHNEPSYKSLRPASVVHQDTNFVSKLPTTVQNKYQEPVELPPQQQNQVVPSTRRRGHGSTDLSFETGYGQQQHQHHRDVPQIVVEDHQHYNSNDNRDVEMEESKDEFDNFDYNNKYTENEILTDVQQDQVRSPFADQIQGVPETSHAKQQNQQVQQVQQQEELGHQRTHSSGKFGKSKRRKRKVGLDDFQFLAVLGKGNFGKVMLAESRHTSKLCAIKVLKKDFIVENDEAESVKSEKRVFLTANKEMHPFLLNLHCCFQTENRIYFVMEYISGGDLMWHIQKNRFTAKRAKFYACEVLLGLKYFHDNGIVYRDLKLDNILLTTKGHIKIGDYGLCKEDMWHKSTTSTFCGTPEFMAPEIVAGKAYDRSVDWWAFGVLLFQMLLCQSPFKGDDEDDIFNAIENDEVKYPINLSRQTVLVLQALLTKDPSQRLGSGPKDAEEIMEHPYFHDVNFDDVLNCRIPAPYIPEVQSEHDYSNFDKEFTSETPRLTPVETVLTSEMQEQFRGFSHISDNATI
Protein: AAA-ATPase At5g40000 (EC 3.6.1.-) (F4KFX5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMMMGDSFGSIGSSMASLFFLWATIQQIFPDHLKITIKEFLLSSFQQLCFAQRVSDHFTNLFSPYVEIHFPESDEYSFNQAFSAIDTYLDSKATDKTKHLRGSQVKESKGLVLKRNEAKVRDEYKGANVWWERVVDNDGNRYYKLTFHNRARTLITNSYIKYVVEEGKSIIVKNKQTRLFTNNLSTQWVFGQNMWRSIEFEHPASFQTLAMDPKKKEEIVNDLIAFSNGKEYYKKIGKAWKRGYLLYGPPGTGKSTMISAMANLLNYNIYDLELTAVKNNSELKKLLTATSSKSIIVIEDIDCSADFTSNRIKKESNSRERYGKEDKDENSVTLSGLLNFIDGIWSACGQERIVVFTTNHLEKLDPALIRRGRMDMHIELSYCTYEAFKILAKNYLDLDGDDAHPLFSEIKALLEETKISPADVAENLMARNQQIDVDKSLNLLISALEEENQYQRSQQEKKKSKFKIFG
Protein: Ribosome biogenesis protein NOP53 (Q9NEU5)
Organism: Caenorhabditis elegans
Function: May play a role in ribosome biogenesis, being required for integration of the 5S RNP into the ribosomal large subunit.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NZM5}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9NZM5}.
Interaction partners:
- Putative rRNA methyltransferase
- Nucleolar GTP-binding protein 1
- mRNA transport homolog 4
- Nucleolar GTP-binding protein 2
- Ribosomal L1 domain-containing protein
- Protein SDA1 homolog
- RRM domain-containing protein
- NLE domain-containing protein
- Ribosome production factor 2 homolog
- Pescadillo homolog
Sequence:
MVAGKRTGAAKGSRHNKKYWRKGTNIDDIEDSIHIKSRQAATGGVISEMKDEDLFIVDRTATANKPVVPKLTKKQQAALEKITKNITQEHVTLPKPSTTSKILKKPAKLPRGNAILALKKGPKAAAPAAKKKNFDVWTTDLTPKIPKSKLENQEAAEHFLKVVKKKQPKTPGKSITSLLPAVQIAEGGASYNPESAEYQEYVAKIAGEEQKLIDHEAKIKAGIEPQWEKVTTEHERFLEMAEGLRIHPKYGKDDEEEEEAGNSEKSMKTGGEAEPKSQRVECDRMTKEQKKKKAKAQKLDKEEKRRLEEKAKEQDSHNVYRTKQLHKELDEEEKQRHEESEVRKKEKLINKLTKRQQLGKGKFVDAEDPFLLQEELTGNLRQLKPQGHVLDDRMKSLQRRNMLPIGGDKEKRRIKNRLKSKVVEKRSAKNIVKGSRVI
Protein: Amino acid ABC transporter (A0A0H2UQP0)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MREIMLLQLFSLYFESLILTTILVLIFLGIWIGLRAMSGVDKTARARQAHLYDMIMIGVLVVPVLSFAVMSLILVFKA
Protein: Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3) (Q86YD5)
Organism: Homo sapiens (Human)
Function: May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSANSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV