wanglab/gogpt-training-data huggingface dataset:
Protein: Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) (P23526)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine. Binds copper ions (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:28647132}. Endoplasmic reticulum {ECO:0000269|PubMed:28647132}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Interaction partners:
- Methionine synthase
- Betaine--homocysteine S-methyltransferase 1
- Cystathionine beta-synthase-like protein
- Cystathionine gamma-lyase
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
- S-adenosylhomocysteine hydrolase-like protein 1
- DNA
- DNA
- DNA
- Kynurenine--oxoglutarate transaminase 1
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
Protein: Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase) (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Q9VKX7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. Involved in cuticle differentiation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Dolichyl-phosphate beta-glucosyltransferase
- Dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase Alg3
- Alpha-1,2-mannosyltransferase Alg9
- Dol-P-Man:Man
- Dolichol-phosphate mannosyltransferase subunit 1
- UDP-glucose:glycoprotein glucosyltransferase
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- GDP-Man:Man
- Dol-P-Glc:Glc
Sequence:
MRSEILASAFLGLAVRSIISLYSYSGFDSPPMHGDYEAQRHWQEITVNLAVGEWYTNSSNNDLQYWGLDYPPLTAYHSYLVGRIGASIDPRFVELHKSRGFESKEHKRFMRATVVSADVLIYLPAMLLLAYSLDKAFRSDDKLFLFTLVAAYPGQTLIDNGHFQYNNISLGFAAVAIAAILRRRFYAAAFFFTLALNYKQMELYHSLPFFAFLLGECVSQKSFASFIAEISRIAAVVLGTFAILWVPWLGSLQAVLQVLHRLFPVARGVFEDKVANVWCAVNVVWKLKKHISNDQMALVCIACTLIASLPTNVLLFRRRTNVGFLLALFNTSLAFFLFSFQVHEKTILLTALPALFLLKCWPDEMILFLEVTVFSMLPLLARDELLVPAVVATVAFHLIFKCFDSKSKLSNEYPLKYIANISQILMISVVVASLTVPAPTKYPDLWPLIISVTSCGHFFLFFLWGNVQQFSSKLS
Protein: Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a) (Q61098)
Organism: Mus musculus (Mouse)
Function: Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q13478}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Interleukin-18 receptor accessory protein
- Interleukin-18
- Interleukin-33
- Interleukin-1 receptor accessory protein
- Interleukin-12 receptor subunit beta-2
- Interleukin-18-binding protein
- Interleukin-7 receptor subunit alpha
- Single Ig IL-1-related receptor
- Interleukin-36 receptor antagonist protein
Sequence:
MHHEELILTLCILIVKSASKSCIHRSQIHVVEGEPFYLKPCGISAPVHRNETATMRWFKGSASHEYRELNNRSSPRVTFHDHTLEFWPVEMEDEGTYISQVGNDRRNWTLNVTKRNKHSCFSDKLVTSRDVEVNKSLHITCKNPNYEELIQDTWLYKNCKEISKTPRILKDAEFGDEGYYSCVFSVHHNGTRYNITKTVNITVIEGRSKVTPAILGPKCEKVGVELGKDVELNCSASLNKDDLFYWSIRKEDSSDPNVQEDRKETTTWISEGKLHASKILRFQKITENYLNVLYNCTVANEEAIDTKSFVLVRKEIPDIPGHVFTGGVTVLVLASVAAVCIVILCVIYKVDLVLFYRRIAERDETLTDGKTYDAFVSYLKECHPENKEEYTFAVETLPRVLEKQFGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTNGARRELESGLHEALVERKIKIILIEFTPASNITFLPPSLKLLKSYRVLKWRADSPSMNSRFWKNLVYLMPAKAVKPWREESEARSVLSAP
Protein: Probable glucuronoxylan glucuronosyltransferase F8H (EC 2.4.1.-) (FRA8 homolog) (Protein FRAGILE FIBER 8 homolog) (Q6NMM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Probably involved in the synthesis of the glycosyl sequence at the glucuronoxylan reducing end.
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:19224953}; Single-pass type II membrane protein {ECO:0000305|PubMed:19224953}.
Interaction partners:
- Probable beta-1,4-xylosyltransferase IRX14H
- Probable beta-1,4-xylosyltransferase IRX9H
- Beta-1,4-xylosyltransferase IRX14
- Probable galacturonosyltransferase-like 1
- Beta-1,4-xylosyltransferase IRX9
- Probable galacturonosyltransferase 12
- UDP-glucuronate:xylan alpha-glucuronosyltransferase 1
- Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 4
- UDP-glucuronate:xylan alpha-glucuronosyltransferase 2
- Xylan O-acetyltransferase 1
Sequence:
MSLDIKKPNITKTKKKKTGFVVKMQLNNNRGGNKRNIFIFFFFRNYYTWILWFCLSLYFFTSYFSVEDQSSPSSIRLLSNHKTSSSLPSRALIESSAIKTTSIGLFTGMKIYVYDLPASYNDDWVTASDRCASHLFAAEVAIHRALLSSDVRTLDPDEADYFFVPVYVSCNFSTSNGFPSLSHARSLLSSAVDFLSDHYPFWNRSQGSDHVFVASHDFGACFHAMEDMAIEEGIPKFMKRSIILQTFGVKYKHPCQEVEHVVIPPYIPPESVQKAIEKAPVNGRRDIWAFFRGKMEVNPKNISGRFYSKGVRTAILKKFGGRRRFYLNRHRFAGYRSEIVRSVFCLCPLGWAPWSPRLVESAVLGCVPVVIADGIQLPFSETVQWPEISLTVAEKDVRNLRKVLEHVAATNLSAIQRNLHEPVFKRALLYNVPMKEGDATWHILESLWRKLDDRSYRRSRVLSQREVDM
Protein: Protein bicaudal D homolog 1 (Bic-D 1) (Q8BR07)
Organism: Mus musculus (Mouse)
Function: Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
Subcellular location: Golgi apparatus {ECO:0000269|Ref.4}.
Interaction partners:
- Ras-related protein Rab-6A
- Dynactin subunit 2
- Cytoplasmic dynein 1 light intermediate chain 1
- Dynactin subunit 1
- Cytoplasmic dynein 1 heavy chain 1
- Cytoplasmic dynein 1 light intermediate chain 2
- Protein bicaudal D homolog 2
- Ras-related protein Rab-6B
- piRNA biogenesis protein EXD1
- Cytoplasmic dynein 1 intermediate chain 2
Sequence:
MAAEEALKTVDQYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDGLKQELEQLREAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLNKILEMQNELKQSRAVVTNVQAENERLSAVVQELKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYINLSDSHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLGKLNGDYRTPTTRKGESLHPVSDLFSELNISEIQKLKQQLIQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQNSKEIKAELDCEKGRNSAEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTEEKTKYESKIQMYDEQVTNLEKTSKESGEKMAHMEKELQKMTGIANENHNTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLSRRGVSSPVESRTSSEPVSKENTETSKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLLPPYRHSAHN
Protein: NAC domain-containing protein 87 (ANAC087) (Q9FK44)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to the promoter regions of genes involved in chlorophyll catabolic processes, such as NYC1, SGR1, SGR2 and PAO.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
Interaction partners:
- Gb|AAF63169.1/surp domain-containing protein)
- Bifunctional nuclease 1
Sequence:
MAVVVEEGVVLNHGGEELVDLPPGFRFHPTDEEIITCYLKEKVLNSRFTAVAMGEADLNKCEPWDLPKRAKMGEKEFYFFCQRDRKYPTGMRTNRATESGYWKATGKDKEIFKGKGCLVGMKKTLVFYRGRAPKGEKTNWVMHEYRLEGKYSYYNLPKSARDEWVVCRVFHKNNPSTTTQPMTRIPVEDFTRMDSLENIDHLLDFSSLPPLIDPSFMSQTEQPNFKPINPPTYDISSPIQPHHFNSYQSIFNHQVFGSASGSTYNNNNEMIKMEQSLVSVSQETCLSSDVNANMTTTTEVSSGPVMKQEMGMMGMVNGSKSYEDLCDLRGDLWDF
Protein: Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] (Q9ET78)
Organism: Mus musculus (Mouse)
Function: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads. Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.
Subcellular location: [Junctophilin-2]: Cell membrane {ECO:0000269|PubMed:10949023}; Peripheral membrane protein {ECO:0000269|PubMed:10949023}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:10949023}; Single-pass type IV membrane protein {ECO:0000269|PubMed:10949023}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10949023}; Single-pass type IV membrane protein {ECO:0000269|PubMed:10949023}. Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (PubMed:10949023). In heart cells, it predominantly associates along Z lines within myocytes (PubMed:10949023). In skeletal muscle, it is specifically localized at the junction of A and I bands (PubMed:10949023). {ECO:0000269|PubMed:10949023}.; SUBCELLULAR LOCATION: [Junctophilin-2 N-terminal fragment]: Nucleus {ECO:0000269|PubMed:30409805}. Note=Accumulates in the nucleus of stressed hearts. {ECO:0000269|PubMed:30409805}.
Interaction partners:
- Triadin
- Ryanodine receptor 1
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Calsequestrin-2
- Ryanodine receptor 3
- Caveolin-3
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Ryanodine receptor 2
- Synaptophysin-like protein 2
- Myc box-dependent-interacting protein 1
Sequence:
MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPAADGPMLPSPPVPRGGFALTLLATAEAARPQGLFTRGTLLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDAAAPFDADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKYRHNVLVKGTKRRVLPLKSSKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLAKELAPDFYQPGPEYQKRRLLQEILENSESLLEPPERGLGTGLPERPRESPQLHERETPQPEGGPPSPAGTPPQPKRPRPGASKDGLLSPGSWNGEPGGEGSRPATPSDGAGRRSPARPASEHMAIEALQPPPAPSQEPEVAMYRGYHSYAVRTGPPEPPPLEDEQEPEPEPEPEVRRSDSAPPSPVSATVPEEEPPAPRSPVPAKQATLEPKPIVPKAEPKAKARKTEARGLSKAGAKKKGRKEVAQAKEAEVEVEEVPNTVLICMVILLNIGLAILFVHLLT
Protein: Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) (Q95107)
Organism: Bos taurus (Bovine)
Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O00401}. Nucleus {ECO:0000250|UniProtKB:O00401}. Cytoplasm {ECO:0000250|UniProtKB:Q91YD9}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated. Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm. {ECO:0000250|UniProtKB:Q91YD9}.
Interaction partners:
- Cell division control protein 42 homolog
- Hematopoietic lineage cell-specific protein
- Actin-related protein 2
- Src substrate cortactin
- WAS/WASL-interacting protein family member 1
- Intersectin-1
- Actin-related protein 2/3 complex subunit 2
- Cofilin-1
- Actin-related protein 3
- WAS/WASL interacting protein family member 2
Sequence:
MSSGQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQINNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHSSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPGVGAPPPPPNRMYPPPLPALPSSAPSGPPPPPPPLSVSGSVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTPAGSKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVTDAPESTPPAPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDDEDFEDDDEWED
Protein: General transcription factor IIE subunit 2 (Transcription initiation factor IIE subunit beta) (TFIIE-beta) (Q9D902)
Organism: Mus musculus (Mouse)
Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P29084}.
Interaction partners:
- General transcription factor IIE subunit 1
- General transcription factor IIH subunit 2
- General transcription factor IIH subunit 3
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIF subunit 2
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIH subunit 4
- Cyclin-H
- General transcription factor IIH subunit 1
Sequence:
MDPSLLRDRELFKKRALSTPVVEKRAVPSESPSSSSSKKKKAKVEHGGSSGSKQNSDHNNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMTEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDNHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVSRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVASIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDITPGK
Protein: O-methyltransferase gsfD (EC 2.1.1.-) (Griseofulvin synthesis protein D) (D7PI18)
Organism: Penicillium aethiopicum
Function: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections. The first step of the pathway is the formation of the heptaketide backbone by gsfA which is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units. The resulting benzophenone can undergo a spontaneous dehydration to form norlichexanthone. However, the true precursor for the griseofulvin biosynthesis is not norlichexanthone, but the heptaketide benzophenone that is O-methylated at 3-OH by gsfB to produce griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C. Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B. The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin. Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin.
Interaction partners:
Sequence:
MSTPEQWIQEFEALCSRASILFPSGIEDENIRIRALRIAEKAVHQLHTPMTFAEAQTWAPLELFGAGVACEMGIFDVLSKSSVPLSPVDIATELNTDPALVARIMRLLDAHYMVDQVTLGQYAANAITRDYVQPYRKGNVMTQVALMPSYFALPAWLRDNDYKVRPDANHCAWQVGANTTKTFWEMPRTTQEDDFVTFYPFEAVFSTSNVDDILFVDIGGGLGHQAMRVRSAFPRSRGRIIVQDLPQVTNKITTASLPDVEIMDHDMADPQPVKGARVYYLRGVLHNHADHISIKYLSQFAAAMSPESRLLIHEALATDLNPTKNITRFDLSMLASCGGAQRSEAEQKALLEKVGLEVSGVWSTPRDWSIMEARLKRE
Protein: Uncharacterized protein YejA (P33913)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Inner membrane ABC transporter permease protein YejB
- Uncharacterized ABC transporter ATP-binding protein YejF
- Inner membrane ABC transporter permease protein YejE
- Probable cyclic di-GMP phosphodiesterase PdeN
- Glutathione import ATP-binding protein GsiA
- Periplasmic oligopeptide-binding protein OppA
Sequence:
MIVRILLLFIALFTFGVQAQAIKESYAFAVLGEPRYAFNFNHFDYVNPAAPKGGQITLSALGTFDNFNRYALRGNPGARTEQLYDTLFTTSDDEPGSYYPLIAESARYADDYSWVEVAINPRARFHDGSPITARDVEFTFQKFMTEGVPQFRLVYKGTTVKAIAPLTVRIELAKPGKEDMLSLFSLPVFPEKYWKDHKLSDPLATPPLASGPYRVTSWKMGQNIVYSRVKDYWAANLPVNRGRWNFDTIRYDYYLDDNVAFEAFKAGAFDLRMENDAKNWATRYTGKNFDKKYIIKDEQKNESAQDTRWLAFNIQRPVFSDRRVREAITLAFDFEWMNKALFYNAWSRTNSYFQNTEYAARNYPDAAELVLLAPMKKDLPSEVFTQIYQPPVSKGDGYDRDNLLKADKLLNEAGWVLKGQQRVNATTGQPLSFELLLPASSNSQWVLPFQHSLQRLGINMDIRKVDNSQITNRMRSRDYDMMPRVWRAMPWPSSDLQISWSSEYINSTYNAPGVQSPVIDSLINQIIAAQGNKEKLLPLGRALDRVLTWNYYMLPMWYMAEDRLAWWDKFSQPAVRPIYSLGIDTWWYDVNKAAKLPSASKQGE
Protein: Uncharacterized protein P8B7.26 (O94274)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Note=Localizes at the cell tip and barrier septum.
Interaction partners:
- Uncharacterized WD repeat-containing protein C17D11.08
- S-adenosylmethionine synthase
Sequence:
MFDSTKKSLHSMSDSANRFQNKITSKLPGEHGEDAMYDIRSVHGTGPRLSIKYVDVTKLPPPPKHASQLRAGGSSTGSTPRTASPAVGNQDYSKPSYSQPSYSQPSQPPKEPALPSRGTPSLPSRPGSRPSVLNQEQVPPPPVRPNVMSQMPPPPSYSSSGSYSQTYQSNANYTASSPLPTASANAPLPVPPPRRVSQNSSYASGSVPAATAASTASPVKKPPPPAPPKPRRLAARTSSNSSGVSSPTSVPPPVQRNTRPNL
Protein: LD30050p (Murashka, isoform A) (Murashka, isoform B) (Q8SX72)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLNSNATGGNNHGGSSRRPFTRNSSSVRSQRGGGGGLGGRMVYSPHTHPHVQQQQQQQQQQQQQGQQRSSNNGNNNLWLGNSPWCNVNLNGGNSGNNNNNGGNNNNNNGGNISSNNNSNNVNNKDANPNCHSQGQGPGNSPNLGHNHQRGYNNGNNNRGIGNGIVNGNTNGPPDYMNYRRGVCPAQSRDYSGNGNGNNNGHGHNGRRYMSDNLNNPSSSMNGLINSGHHQRNYNDRNLNNHFGNSEQNGGPDHRDRAEGSSYNFMRNGGGSGGGGYGRNGSHYQHMAYGNNNGASTSTGGPGLMGELPSGSGLSGSSLSLNNGPGGLNSDSPSRKRRRISGRPPNGPQPQHRCPMAHMQQGSPPLRRPRLRDVATSTQQQQQQYGHQVHHPQQQQQQPPSNYHPMHHHQPQPHYVPQQQVPPPHVQRSPWDLGSSGGSSGGATSSSSVGPILQQVQAPPQPPSHQQAVGYPQAPPQPASLMVDLNLNQVPVNLQLRPSEPFWASFCTYPIPAQARLAPCHLHGVYTQPFPAAPPPGLAAPPLQQQHQPLIQAQQMISQATLTAQQQQRDVVAIATANLGPIEAPGAHGHPHAHPHAHPHAHQLPPGIHITPLSGAAAAAATHHLHSTAAAAAAVAAGAQITTAQQILFSSDRRTFPPHRRIPRFWTANHGHRHVLPPQSLAAHQAPVQIQATSGIINPGFLLNFLAMFPLSPYNQHDLSSGDTNETENYEALLSLAERLGEAKPRGLTRNEIDQLPSYKFNPEVHNGDQSSCVVCMCDFELRQLLRVLPCSHEFHAKCVDKWLRSNRTCPICRGNASDYFDGVDQQQQSQATAGAAAALSGTSGGSAGVAGTSEASAATANPQQSQAA
Protein: Casein kinase II subunit beta (CK II beta) (Phosvitin) (P28021)
Organism: Xenopus laevis (African clawed frog)
Function: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Participates in Wnt signaling.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P67870}.
Interaction partners:
Sequence:
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTMR
Protein: Chromosome-associated kinesin KIF4 (Chromokinesin) (P33174)
Organism: Mus musculus (Mouse)
Function: Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Required for mitotic chromosomal positioning and bipolar spindle stabilization.
Subcellular location: Nucleus {ECO:0000269|PubMed:7929562}. Chromosome {ECO:0000269|PubMed:7929562}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:7929562}.
Interaction partners:
- Protein regulator of cytokinesis 1
- Kinesin-like protein KIF20A
- Kinesin-like protein KIF11
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Kinesin-like protein KIF22
- Abnormal spindle-like microcephaly-associated protein homolog
- Kinesin-like protein KIF23
- Maternal embryonic leucine zipper kinase
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Disks large-associated protein 5
Sequence:
MKEEVKGIPVRVALRCRPLVSKEIKEGCQTCLSFVPGEPQVVVGNDKSFTYDFVFDPSTEQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEINKKSDFEFTLKVSYLEIYNEEILDLLCSSREKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLREGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIINIDPQAAELNHLKQQVQQLQILLLQAHGGTLPGDINVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRHAACKVDLQKLVETLEDQELKENIEIICNLQQVIAQLSDEAAACMTATIDTAGEADTQVQSSPDTSRSSDVFSTQHALRQAQMSKELIELNKALALKEALAKKMTQNDNQLQPIQFQYQDNIKNLESEVLSLQREKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLQEQSKLLKLKESTEHTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQKEVAEKRKETQSRGMESTAARMKNWLGNEIEVMVSTEEAKRHLNGLLEERKILAQDVAQLKEKRESGENPPLKLRRRTFSYDEIHGQDSGAEDSIAKQIESLETELELRSAQIADLQQKLLDAESEDRPKQRWESIATILEAKCAIKYLVGELVSSKILVSKLESSLNQSKASCIDVQKMLFEEQNHFAKIETELKEELVKVEQQHQEKVLYLLSQLQQSQMTEKQLEESVSEKEQQLLSTLKCQEEELRKMQEVCEQNQQLLQENSAIKQKLTLLQVASKQKPHLTRNIFQSPDSSFEYIPPKPKPCRIKEKCLEQSFAVEGLQYYSEPSVAEQDNEDSDDHADEEWIPTKLVKVSKKSIQGCSCKGWCGNKQCGCRKQKSDCNVSCSCDPTKCRNRHQNQDNSDAIELNQDSENSFKLEDPTEVTSGLSFFHPICATPSSKILKEMCDADQVQLKQPVFVSSSDHPELKSIASESQENKAIGKKKKRALASNTSFFSGCSPIQEESH
Protein: Probable metabolite transporter C2H8.02 (Q9Y7Q9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Golgi apparatus {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Uncharacterized RING finger protein C6B12.07c
- Uncharacterized transporter C3B8.04c
Sequence:
MGFKLNPFSKKPKDEEPLPLEQYEASEQKILGLVTKKEAKLLAIAGTGFLLDSYDLFIINLVSPILAYLYWGGLTGHQDYPSGIRGVVNAATNIGNIMGQLLFGFLGDFFGRKFVYGKEMMVVIIATILIICLPDRIPTPTAKMMWLFAFRVMLGIGIGGDYPMSASITSEQSLINRRGALLAWIFSNQGWGTLAGCVATLIILACFEKPLNDRGEYTKLNGVWRIQFGIALFPAVIVLIPRLRMQESEQFKNSKNMKSPGEGDLDSASQIELHDFKKKESLTAEFTTSSPSTASLSDKKNPGSVHIRPNNEVAPSSAPSRAPSTTSVESNTEGKESDIQTGSSFVSYFKEWRHAKLLIGSALSWFLLDIAFYGINLNQSVILQEMGFNKGVNEYHILQKNAIGNLIIAVAGYIPGYWVSVVLIEVMGRKWIQIQGFLICCLLFGVLAGTWETISTGGRFACVALAQFFFNFGPNTTCFVIPAEVFPSRVRAFSHGICAACGKAGAILSALLFNKLTEVIGFGNVLWIFFGCMVAGAVVTLILPETANRDADLIDRLEIAAMQQGRTSIIDRSEKWAWWKHGI
Protein: Endoplasmic reticulum transmembrane protein (Q9W0M4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367026}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367026}.
Interaction partners:
- Krueppel target at 95D, isoform A
- Mitochondrial fission 1 protein
- Ubiquitin-conjugating enzyme E2 N
- LD30122p
- dynamin GTPase
Sequence:
MSLVWTLIAGFLYAEIALVLLLVLPVLTPYRWNRFFKSKFLSMLGQQAHIYFLLIMGILVIFLLEAIREMRKYSGLQQSNEVHLNVEMQHSMKLFRAQRNFYISGFAIFLALVIRRLVNLICTQANLMAQSEASFKQAQSATAAARSLLENKNTEKAKEAGEDTTLIELNKLRERVQELTSDLNREKKDKEAVKSQAESINREYDRLTEEYSKLQKKITIGGGGNKDD