wanglab/gogpt-training-data huggingface dataset:
Protein: BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] (P70444)
Organism: Mus musculus (Mouse)
Function: Induces caspases and apoptosis. Counters the protective effect of BCL2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9873064}. Mitochondrion membrane {ECO:0000269|PubMed:9873064}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P55957}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269|PubMed:9873064}.; SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p15]: Mitochondrion membrane {ECO:0000269|PubMed:9873064}. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000269|PubMed:9873064}.; SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p13]: Mitochondrion membrane {ECO:0000269|PubMed:9873064}. Note=Associated with the mitochondrial membrane. {ECO:0000269|PubMed:9873064}.
Interaction partners:
- Apoptosis regulator BAX
- Bcl-2-like protein 1
- Bcl-2 homologous antagonist/killer
- Apoptosis regulator Bcl-2
- Caspase-8
- Bcl-2-related protein A1
- Bcl-2-like protein 11
- Bcl-2-binding component 3
- Phorbol-12-myristate-13-acetate-induced protein 1
- Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Sequence:
MDSEVSNGSGLGAEHITDLLVFGFLQSSGCTRQELEVLGRELPVQAYWEADLEDELQTDGSQASRSFNQGRIEPDSESQEEIIHNIARHLAQIGDEMDHNIQPTLVRQLAAQFMNGSLSEEDKRNCLAKALDEVKTAFPRDMENDKAMLIMTMLLAKKVASHAPSLLRDVFHTTVNFINQNLFSYVRNLVRNEMD
Protein: AAA+ ATPase domain-containing protein (Q57ZQ6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Kinesin, putative
- IST1 homolog
- ATP-dependent Clp protease subunit, heat shock protein 78
- ATP-dependent Clp protease subunit, heat shock protein 100
Sequence:
MLSCLRQIHHRKKKEPCVLSTAPAEEGANLLRRAVYDTIVSSEHHHIQTLQESQRIIESSEFETLEEKKAMQRMGSFMVSVVQKHMQAVTFESTLAATCRKQQRQKPRGVSNVIMGSEEEVGQLLLMNRTMALGTTCTFLEGLINHDKELALAPILCTSEEREAEPVRHPSVQDPVPFLRQSHPALGAILLDTAEQAVGATQKDGRELSMTQGSGTLSQLGNRFTQSTLTQQREGVLKRRRQDDNSDNDNDGSVTSSCKRNPSFVVRIGEGVLKSRKQCDPDVEGTVTGSLPTPATDQTKRQETQRSEQNRIVQSQRSATSSQPHTQKGQPLPSGTTDENSAPRLSPLTGSTAKVSGSLQRSQLASGEGEAIERAENSSTANRRGDPWTGRHNAHGSRAGKGGDEENERGPGSSAGGFVTACEQLKMDLKAGRGVPPQFSMERRKPAPGVRYPGFTPPFQRQPVRPNGDVPSADKGTQDSTGGTPPPPPPTGSVSSTVKSNRLSPARRLKQRSRASSSDDDRSDFPSSLLLPDGSIPPILQSLDARLVAQVASEIIEHSGGGGGVGWNAIAGLEHAKRSVEEVIVWPLQRPEFFVGLRGPPRGLLLFGPPGTGKTMIARAIANRAQCTFFNISASSVMSKWMGDGEKLVRCLFAVAVVKQPSVIFIDEIDSLLSMRSEGEMDAVRRVKTEFLVQLDGVATNQGDRVLLIGATNRPDELDEAARRRLEKRLYIPLPDINARAQLIKMLLEQTGTNCGQAVGQSAESAGKAASSVSDMDEKSIMHVATATEGYSGSDIKQLCSEAAMYAVRELKEKLKDLEIRELRPIQRKDFVRALRRSRPSVGADEVRRYVEWNKKFGSFPTGVMDADEEEEEEDEGEGEGEATIKR
Protein: LD03592p (Synaptosomal-associated protein 29kDa) (Q9W1I8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Vesicle-associated membrane protein 7
- Syntaxin 17, isoform B
- LD23667p
- LD34211p
- Syntaxin-1A
- Autophagy-related 14
- Alpha-soluble NSF attachment protein
- HL02043p
- Neuronal synaptobrevin, isoform J
- Secretory 22, isoform B
Sequence:
MAHNYLQPVHDHFDDVDRFEDVDDDLFLQNKRTGAAKLPQQRSTNPFEMDDDDEEEITSSPSVAAQRLAYAEKRRAIEQRTLDSTNKSLGLLYETQEVGKATAVELAKQREQLEKTSHQLDEISSTLRFSQRHLTGLKSVFGGLKNYLSGNRDQPPTATGSPTGSQSSQEANSNINQGACGGASPSAPLSPAERYDNHPVSQLRGDPSSTYQPQRQAANPFQAQIDSNLEEMCSNLSVLKMLATDLGGEIESQNELLDNMNYKIEDVDLKIHKQNKDMSKLLKK
Protein: Protein delta homolog 1 (DLK-1) (Adipocyte differentiation inhibitor protein) (Preadipocyte factor 1) (Pref-1) [Cleaved into: Fetal antigen 1 (FA1)] (Q09163)
Organism: Mus musculus (Mouse)
Function: May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation.
Subcellular location: Membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O70534}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- CD209 antigen-like protein A
- Insulin-like growth factor 2
- Neurogenic locus notch homolog protein 2
- Retrotransposon-like protein 1
- Thyroxine 5-deiodinase
- Insulin-like growth factor-binding protein 1
- Growth factor receptor-bound protein 10
- Scm-like with four MBT domains protein 2
- Retrotransposon-derived protein PEG10
Sequence:
MIATGALLRVLLLLLAFGHSTYGAECDPPCDPQYGFCEADNVCRCHVGWEGPLCDKCVTAPGCVNGVCKEPWQCICKDGWDGKFCEIDVRACTSTPCANNGTCVDLEKGQYECSCTPGFSGKDCQHKAGPCVINGSPCQHGGACVDDEGQASHASCLCPPGFSGNFCEIVAATNSCTPNPCENDGVCTDIGGDFRCRCPAGFVDKTCSRPVSNCASGPCQNGGTCLQHTQVSFECLCKPPFMGPTCAKKRGASPVQVTHLPSGYGLTYRLTPGVHELPVQQPEQHILKVSMKELNKSTPLLTEGQAICFTILGVLTSLVVLGTVAIVFLNKCETWVSNLRYNHTFRKKKNLLLQYNSGEELAVNIIFPEKIDMTTFNKEAGDEEI
Protein: Phosphoacetylglucosamine mutase 2 (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Q09770)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Glucosamine 6-phosphate N-acetyltransferase
- Probable UDP-N-acetylglucosamine pyrophosphorylase
- Probable glutamine--fructose-6-phosphate aminotransferase
- Phosphoacetylglucosamine mutase 1
- UPF0654 protein C11D3.01c
- Phosphoglucomutase
- Ornithine carbamoyltransferase, mitochondrial
Sequence:
MSDAEDSDSIVNEFVTAIVRESDKFAKVHSYPMQYGTGGYRADAELLSSVAFRTGVIASFLSAKLHGQPVGLMVTASHNASSENGLKIVNILSSLDSSKWEAYLDQVVNADSADELTVCLTSILKKAKIIPGSEARVFVGYDSRSTSEILAQAVIDGIVVCKAKYENFGLLTTPQLHYMVKASQTYGTPDAIGEPTERGYFEKLSKAYQSLMTGKKIKGTVLIDAANGVGAAKIKELAKYIDPKLFPIEIVNDNIDNPELLNNSCGADFVRTQQKPPNGISAPKHARCASFDGDADRIVYFAFGSHSFHLLDGDKICALFAQFLIDLIRSTGLDLQVGIVQTAYANGASTAFFQKTLKVPVLCVSPGLKHLYHAAQAYDVGVFFEANGHGTILVSHAALSKIISHEVLSPAQFNALKTLKTVFELINQTDGDAITNLLLVEVILAHKNCTLKEWNQLYSEIPSRLIRCEVEDRSIYTTTDAEQKLVTPEGLQEKIDALVAKYTGGRAFVRSSGTEDAVRVYAEASSRGESEDLALRIVELLH
Protein: 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12) (Q03393)
Organism: Homo sapiens (Human)
Function: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
Interaction partners:
- GTP cyclohydrolase 1
- Sepiapterin reductase
- Receptor-type tyrosine-protein phosphatase alpha
- Tyrosine-protein phosphatase non-receptor type 12
- Tyrosine-protein phosphatase non-receptor type 7
- Carbonyl reductase 1])
- Aldo-keto reductase family 1 member B1
- Aldo-keto reductase family 1 member C3
- Alkaline phosphatase, placental type
- Alkaline phosphatase, tissue-nonspecific isozyme
Sequence:
MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE
Protein: SPX domain-containing membrane protein At4g11810 (Q9T050)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- At1g20770
- Phosphate transporter PHO1 homolog 10
- Inorganic pyrophosphatase 2
- Transmembrane protein
- Transcription factor bHLH7
- Inorganic pyrophosphatase 1
- Inorganic phosphate transporter 1-4
- Probable inorganic phosphate transporter 1-5
- Phosphate transporter PHO1 homolog 1
- Transcription factor UNE12
Sequence:
MVAFGKKLKERSIEEWQEYYINYKLMKKKVKQYGPQIEVGSLDRRHVLKDFSRMLDHQIEKIALFMLEQQGLLSSRLQKLREWHDTLQDEPDLSQIAKLREAYRAVGQDLLKLLFFIDMNAIGIRKILKKFDKRFGYRFTNYYVKTRADHPYSQLQQVFRHVGLGAVVGAISRNLHELQNNEGSYLSIYDQPVLPLQDPVVDSIKNAVDRLTHSTNFLNFMAQHALIMQDDEDLLMLPPDEQAEKEEGRYHFMSLLLNLANTFLYMVNTYIIVPTADDYSMSLGAAATVCGVVIGAMAVAQLFSSVYFSAWSNKSYFKPLIFSSIVLFFGNLLYALAYDFNSLALLLIGRLFCGFGSARAVNRRYISDCVPLKIRMQASAGFVSASALGMACGPALAGLLQTDFKIKNVTFNQDTLPGWVMAVAWLLYLVWLAISFREPAREPEEIHTSQESTSEQIFCGEADQDGNIEKGLKKPLLLASEETEHDEEDDGDGSEESSDDSRKPANSFVAAYKLLTPSVKVQLLIYFMLKYAMEILLSESSVVTTYYFGWSMSSVSIFLFCLGLTVLPVNLVVGSYISNMFEDRQILLASEIMVCIGIVLSFHVVIPYTVPQYVISGFIMFVSAEVLEGVNLSLLSRVMSSRLSRGTYNGGLLSTEAGTIARVIADATITLAGFLGQSMLLNVTLLPSLIICVLSILATCYTYNSLY
Protein: Type II secretion system core protein G (Q9I5P4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004377}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004377}.
Interaction partners:
- Type II secretion system protein K
- Type II secretion system protein HxcR
- Probable type II secretion system protein
- Probable type II secretion system protein
- Type II secretion system core protein G
- Probable type II secretion system protein
- Type II secretion system core protein G
- Type II secretion system protein I
- Type II secretion system protein F
- Type II secretion system protein K
Sequence:
MDVVQFSSSPKGHRGQRGFTLIEIMVVVVILGILAAMVVPKVLDRPDQARATAARQDISGLMQALKLYRLDQGRYPSQAQGLKVLAERPADASASNWRSYLERLPNDPWGKPYQYLNPGVNGEIDVFSLGADGQPGGEGINADIGSWQL
Protein: Alliin lyase 1 (Alliinase-1) (EC 4.4.1.4) (Cysteine sulphoxide lyase 1) (Q01594)
Organism: Allium sativum (Garlic)
Function: Able to cleave the C-S bond of sulfoxide derivatives of Cys to produce allicin, thus giving rise to all sulfur compounds which are responsible for most of the properties of garlic, such as the specific smell and flavor as well as the health benefits like blood lipid or blood pressure lowering.
Subcellular location: Vacuole.
Interaction partners:
Sequence:
MVESYKKIGSCNKMPCLVILTCIIMSNSLVNNNNMVQAKMTWTMKAAEEAEAVANINCSEHGRAFLDGIISEGSPKCECNTCYTGPDCSEKIQGCSADVASGDGLFLEEYWKQHKEASAVLVSPWHRMSYFFNPVSNFISFELEKTIKELHEVVGNAAAKDRYIVFGVGVTQLIHGLVISLSPNMTATPDAPESKVVAHAPFYPVFREQTKYFNKKGYVWAGNAANYVNVSNPEQYIEMVTSPNNPEGLLRHAVIKGCKSIYDMVYYWPHYTPIKYKADEDILLFTMSKFTGHSGSRFGWALIKDESVYNNLLNYMTKNTEGTPRETQLRSLKVLKEVVAMVKTQKGTMRDLNTFGFKKLRERWVNITALLDQSDRFSYQELPQSEYCNYFRRMRPPSPSYAWVKCEWEEDKDCYQTFQNGRINTQNGVGFEASSRYVRLSLIKTQDDFDQLMYYLKDMVKAKRKTPLIKQLFIDQTETASRRPFI
Protein: Phytochrome-associated serine/threonine-protein phosphatase 1 (AtFyPP1) (EC 3.1.3.16) (Q9SX52)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalytic subunit of protein phosphatase 6 (PP6) (Probable). Dephosphorylates phosphorylated phytochromes, with a preference toward Pfr forms. Plays a major role in the photoperiodic control of flowering time in long days by modulating phytochrome signals in flowering time control (By similarity). Involved in the regulation of polar auxin transport in roots. Dephosphorylates directly the auxin efflux carriers PIN1 and PIN2, thus promoting their proper polar localization in root cell plasma membrane. Acts antagonistically with the protein kinase PID to regulate the reversible phosphorylation of PIN and polar targeting, subsequently impacting polar auxin transport and plant development. Involved in the regulation of abscisic acid (ABA) signaling during seed germination and postgermination seedling growth. Functions as negative regulator of ABA signaling through direct dephosphorylation and destabilization of ABI5. Acts antagonistically with the protein kinase SRK2E/SNRK2.6 to regulate ABI5 phosphorylation and ABA responses. Involved in the regulation of phosphorylation status in hypocotyl phototropism. Involved in the negative regulation of photomorphogenesis by controlling the stability and transcriptional activity of PIF3 and PIF4 proteins in the dark, via the regulation of their phosphorylation status.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9LHE7}.
Interaction partners:
- PP2A regulatory subunit TAP46
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
- SIT4 phosphatase-associated family protein
- SIT4 phosphatase-associated family protein
- At1g07990/T6D22_5
- SIT4 phosphatase-associated family protein
- Serine/threonine-protein phosphatase 6 regulatory subunit
- Serine/threonine-protein phosphatase 4 regulatory subunit-like protein
Sequence:
MDLDQWISKVKDGQHLSEDELQLLCEYVKEILIEESNVQPVNSPVTVCGDIHGQFHDLMKLFQTGGHVPETNYIFMGDFVDRGYNSLEVFTILLLLKARHPANITLLRGNHESRQLTQVYGFYDECQRKYGNANAWRYCTDVFDYLTLSAIIDGTVLCVHGGLSPDVRTIDQIRLIERNCEIPHEGPFCDLMWSDPEDIETWAVSPRGAGWLFGSRVTTEFNHINNLDLVCRAHQLVQEGLKYMFQDKGLVTVWSAPNYCYRCGNVASILSFNDNMEREVKFFTETEENNQMRGPRTGVPYFL
Protein: Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) (Q9TT37)
Organism: Oryctolagus cuniculus (Rabbit)
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).
Subcellular location: Cell membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P07340}; Single-pass type II membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000250|UniProtKB:P14094}.
Interaction partners:
- FXYD domain-containing ion transport regulator
- Sodium/potassium-transporting ATPase subunit alpha-1
- Sodium/potassium-transporting ATPase subunit alpha
- Sodium/potassium-transporting ATPase subunit alpha
- Sodium/potassium-transporting ATPase subunit alpha
- Sodium/potassium-transporting ATPase subunit beta-2
- Sodium/potassium-transporting ATPase subunit beta-3
- Phospholemman
- Potassium-transporting ATPase alpha chain 2
- cAMP-dependent protein kinase
Sequence:
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQVPQIQKTEIAFRPSDPKSYEEYVVNIVRFLEKYKDSAQKDDMVFEDCGDVPSEPKERGEFNNERGQRKVCRFKLNWLGNCSGIDDETYGYKDGKPCIIIKLNRVLGFKPKPPKNDSLEFSPGTKYNPNVLPVQCTGKRDEDKEKVGSMEYFGMGDYAGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS
Protein: AT-rich interaction domain 1B (A0A0G2JVD3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAARSAAAARARAGSCERRAPSGPRPAPGARDLETGARGAVAAAAPGPILGGGDGGLNNVHHHPLHPRHDLNMAHSASAAAAASSNSAQSGGSEAALKEGGSAAALSSSAAVAASSSSAGPGSAMETGLLPNHKLKAVGEAPAAPPHQQHHHHHAHHHHHHHAHHLHHHHHALQQQLNQFQQPPQPQQQPPPPPPQQQQHPTANNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGSQADPQGQPLLSKPGDEDDAPPKMGEPAGSRYEHPGLGAQQQPAPVAVPGGGGGGPAAVSEFNNYYGSAASASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAGAPSSMDPLQNSHEGYPNSQYNHYPGYSRPGAGGGGGGGGGGGGSGGGGGGGGAGGAGGAAAAAAAAGAGAVAAAAAAAAAAAAGGGGGGGYGGSSSGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGAAAAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPDYSSSSAPPPPSQPQSQAAAAAGAAAGGQQAAAGMGLGKDLGAQYAAASPAWAAAQQRNHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGTHPHSQPQQSSPYPGGAYGPPGAQRYPLGMQGRAPGALGGLQYPQQQMPPQYGQQGVSGYCQQGQQPYYNQQPQPSHLPPQAQYLQPQSQQRYQPQQDMSQEGYGTRAQPPLAPGKSNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMSQYGPQQTGPSMSPHPSPGGQMHPGISNFQQSNSSGTYGPQMSQYGPQGNYSRTPTYSGVPSASYSGPGPGMGINANNQMHGQGPTQPCGAMPLGRMPSAGMQSRPFPGNMSSVPPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLVASSSPYSQPMNNNSNLMGTQAQPYSMTPTMVNSSTASMGLTDMMSPSESKLSVPLKADGKEEGVPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSSTTGEKITKVYELGTEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDAKKQPKLQPPSPANSGSLQGPQTPQSTGSSSMAEVPGDLKPPTPASTPHGQGTPMQSGRSSTVSVHDPFSDVSDSAYPKRNSMTPNAPYQQGMGMPDMMGRMPYEPNKDPFSGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGTSYDRRHEAYGQQYPGQGPPTGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYGSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYNRERMQGPGQMQPHGIPPQMMGGPMQSSSNEGPQQNMWATRNDMPYPYQNRQGPGGPAQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQSSYQTPPSLPNHISRAPSPASFPRSLESRMSPSKSPFLPAMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQRALDHRTGKKDDSQSSEDDSGKEEDDAECLEEEEEEEEEEEEEEEEEEEEEEDSKKTESEGKSSSALAAPDTTADPKETPRQASKFDKLPIKIVKKNNLFVVDRSDRLGRVQEFNSGLLHWQLGGGDTTEHILTHFESKMEIPPRRRPPAPLSSTGKKKELAGKGDSEEQPEKSIIATIDDVLSARPGALPEDSNPGPQTESGKFPFGIQQAKSHRNIRLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDTLAARAIAVQKGSIGNLIGFLEDGVTMAQYQQSQHTLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
Protein: Potassium channel protein (Q81HW2)
Organism: Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLSFLLTLKRMLRACLRAWKDKEFQVLFVLTILTLISGTIFYSTVEGLRPIDALYFSVVTLTTVGDGNFSPQTDFGKIFTILYIFIGIGLVFGFIHKLAVNVQLPSILSNRKKE
Protein: Immunoglobulin superfamily member 11 (IgSF11) (Brain and testis-specific immunoglobulin superfamily protein) (Bt-IGSF) (P0C673)
Organism: Mus musculus (Mouse)
Function: Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity).
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- V-type immunoglobulin domain-containing suppressor of T-cell activation
Sequence:
MTRRRSAPASWLLVSLLGVATSLEVSESPGSVQVARGQTAVLPCAFSTSAALLNLNVIWMVIPLSNANQPEQVILYQGGQMFDGALRFHGRVGFTGTMPATNVSIFINNTQLSDTGTYQCLVNNLPDRGGRNIGVTGLTVLVPPSAPQCQIQGSQDLGSDVILLCSSEEGIPRPTYLWEKLDNTLKLPPTATQDQVQGTVTIRNISALSSGLYQCVASNAIGTSTCLLDLQVISPQPRSVGVIAGAVGTGAVLIVICLALISGAFFYWRSKNKEEEEEEIPNEIREDDLPPKCSSAKAFHTEISSSENNTLTSSNTYNSRYWNNNPKPHRNTESFNHFSDLRQSFSGNAVIPSIYANGNHLVLGPHKTLVVTANRGSSPQVLPRNNGSVSRKPWPQHTHSYTVSQMTLERIGAVPVMVPAQSRAGSLV
Protein: Os02g0548100 protein (Q6YYG5)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MSQEEQRHGRQLPLATSGVITFNGVPLSPLTAGAESDGDDDDVVIVDACNNGKRKVGDGEEEGRGSQGGDDDDDVVAVHGGGGGGGNRACMFAVRERERRRRMNDMFAGIRRLVPNLPEKSSRVEIIDGAIAYIKMLQGEEVRMEAQKQELQRERDRLAMEVAAAAGGAGASSSSSSAAAAAVTVAAYGPAGAVGSSSSSAAAAARANTVVPVPQRAARGATAPTPRPVAPPQAGTWPLPAPAAMPPPPPPPTGAAAVAPPPSLKTWSWGDNVVVSVLGNIGNMTVRAPLRRTGVLAMASAALKRYNITAVTSLSGTDASRTQNMFMFYTIIDMPDRQPQFVHPKVFEAMYRAAAAEIAAWINCY
Protein: Cell cycle associated protein Mob1-2 (Q95UM8)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MKRFKAKLFDSDRTYKPKKKHKEGTERYNLHKFAKSLVRSGDLSAAVKLPQGADLNHWLSVHTVDFYNITNVLYGSLTEFCTNSSCPVMSSGPRYEYLWRDPPEYPKATKVSAPEYVRLLMEWIERQINDERVFPSEDRNPYPPDFADRVKACFKRLFRVYAHVYYSHFAKIRELQEESHINTALKHFMYFVWEFDLIPREEVSPLRELLVNLMGQRAKEKLEVP
Protein: Golgi reassembly stacking protein (GRASP homologue), putative (Q386P4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
Interaction partners:
- Vesicle tethering protein Uso1/P115-like head domain-containing protein
- Sec1 family transport protein, putative
- Syntaxin 5
- peptidylprolyl isomerase
- Uncharacterized protein
- Protein transport protein SEC23
- Protein transport protein SEC23
- 26S proteasome regulatory subunit 4 homolog
- Cornichon protein
- Vesicle-associated membrane protein, putative
Sequence:
MGQGKSDAKRPLKDIEGLQIVRVLPYSPSHSAGLIPFFDIITAVDGKQMEVDGESVEKFKYYVAGRRDETITLTVYNLYIHNYRDVHCVASSTWGGGGLLGCSVEWCQAEKCVERCWHVVDVIPGSPVAKCGEIKEGRDYIIGIQKADELVTALIKDEDDLYTRVELWRTAQSAALRRLQRNSFVPTGASREDRGLQTAGQLLLLVYDSVNIEVKEVLVDFGNDIYAPLGMNLATGLLHLIPSPPKSLADNGRVTGTVGISATSAGDDSSCSVNSSSNLPTVTAFVLATGGVLRIGKTAPTVLAPPKPGATGSPNGPPPPFTSPVVTEMQAPQMLPEFPSRVHVPPQKYHAAANSTAFPKEIEGVHEQPPTPLFPMEGIPNGLHAPLPNPAGLFMNTVSPRKWQEDVAAVATIPAAEGNPSCATTSHDPPVPSYSAQQHTQQQFGLPFSQASYQQQPPPQIIRQSLLPDVTNMVDEQLPVSRVPPPLAFPIIKPATPSR
Protein: Acetyltransferase (O53594)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved protein
- Secreted protein
- Glutathione S-transferase domain-containing protein
- N-acetylmuramoyl-L-alanine amidase CwlM
Sequence:
MSARITALRLEAFEQLPKHARRCVFWEVDPAILGKDDHLADPEFEKEAWLSMVMLEWGSCGQVATAVPDERSHAEPPCLGYVLYAPPSAVPRAQRFPTAPVSADAVLLTSMGIERGQADDDLPHSLIARVIEELVRRGVRALEAFGRTPAATDLQNPGAVTPDVRPVLEALGDCCVEHCIIDANFLMDVGFVVVAPHPYFPRLRLELDKGLGWKAEVEAALERLLENARLQEPIAAGSTAGNTS
Protein: Ras-related protein Ral-B (EC 3.6.5.2) (P36860)
Organism: Rattus norvegicus (Rat)
Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P11234}; Lipid-anchor {ECO:0000250|UniProtKB:P11234}; Cytoplasmic side {ECO:0000250|UniProtKB:P11234}. Midbody {ECO:0000250|UniProtKB:P11234}. Note=During late cytokinesis, enriched at the midbody. {ECO:0000250|UniProtKB:P11234}.
Interaction partners:
- Exocyst complex component 2
- Exocyst complex component 8
- RalA-binding protein 1
- Ral guanine nucleotide dissociation stimulator
- Ral guanine nucleotide dissociation stimulator-like 2
- Phospholipase D1
- Ral guanine nucleotide dissociation stimulator like 1
- Phospholipase D2
- Ras-related protein Ral-A
- Ras-related C3 botulinum toxin substrate 1
Sequence:
MAANKGKSQGSLVLHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARGKAEEWGVQYVETSAKTRANVDKVFFDLMREIRAKKMSENKDKNGRKSGKSKKSFKERCCLL
Protein: Uncharacterized protein 4 (P86738)
Organism: Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone)
Subcellular location: Secreted {ECO:0000269|PubMed:21050442}.
Interaction partners:
Sequence:
MNSLIFLAVICSTAYVAFAQNTPIRPPFLPGPPAAGAPRIPAKGVAGLARQPQKSLLNNPYLMMMGDKYFEVAALDMLMDPSSQVSPIQQMVIAKSADLSPVDMMVANRLRGAQGTGMRSMYFPAILAMM
Protein: S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) (Q13126)
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Subcellular location: Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03155}.
Interaction partners:
- Methylthioribose-1-phosphate isomerase
- Spermine synthase
- Adenine phosphoribosyltransferase
- Spermidine synthase
- Cyclin-dependent kinase inhibitor 2A
- Bifunctional epoxide hydrolase 2
- 5'-nucleotidase
- Melanocyte-stimulating hormone receptor
- Cyclin-dependent kinase 4 inhibitor B
- 5'-deoxynucleotidase HDDC2
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH