wanglab/gogpt-training-data huggingface dataset:
Protein: Tektin-3 (A6H782)
Organism: Bos taurus (Bovine)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:27883267, ECO:0000269|PubMed:37327785}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000269|PubMed:19478333, ECO:0000269|PubMed:26268136, ECO:0000269|PubMed:27883267}; Peripheral membrane protein {ECO:0000305}. Note=In spermatozoa, preferentially localizes to the flagella, but also found in the head (By similarity). In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (By similarity). Not detected in the central axonemal region of the flagellum (By similarity). Associates with the acrosome membrane in the equatorial segment of the sperm head (PubMed:27883267). Also detected just below the plasma membrane in the post-acrosomal region where it might localize to the postacrosomal dense lamina (PubMed:27883267). However, other studies report little or no expression in the postacrosomal region (By similarity). Translocates from the postacrosomal region to the equatorial segment after sperm activation (PubMed:27883267). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (PubMed:27883267). Some studies report strong expression in the anterior acrosomal cap region (PubMed:19478333, PubMed:26268136). However, other studies report little or no expression in the acrosomal cap (PubMed:27883267). {ECO:0000250|UniProtKB:Q4V8G8, ECO:0000250|UniProtKB:Q9BXF9, ECO:0000269|PubMed:19478333, ECO:0000269|PubMed:26268136, ECO:0000269|PubMed:27883267}.
Interaction partners:
- EF-hand domain-containing protein 1
- RIB43A-like with coiled-coils protein 2
- Tektin-2
- Outer dynein arm-docking complex subunit 4
- Tektin bundle-interacting protein 1
- EF-hand domain-containing family member C2
- Calaxin
- Outer dynein arm-docking complex subunit 1
- Tubulin beta-4B chain
- Tektin-4
Sequence:
MELLGSTLTATYAHPRPTPTNFLPAISTMASTYRDRFPHYNLTHSLSLPWRPSTYYKAASNWPTLDPYCTRSQRVSESTMLPFVSNRTTLFTRYTPDDWYRSNLTNFQESNTSRHNSERLRVDTSRLIQDKYQQTRKTQADSTQNLGERVNDIGFWKSEIIHELDAMIGETNELTDIKKRLERALMETEAPLQVARECLFHREKRMGIDLVHDEVEKELLTEVDTILCCQERMKLYLDKAIAQLAANRAAQHELEKDLSDKQSAYRIDDKCHHLRNTSDGVSYFHGVERVDATVSVPESWAKFTDDNILRSQSERAASAKLRDDIQNVLVVTANEMWNQFNKVNLAFTNRIAETADAKNKIQTHLAKTLQEIFQTEMTIESIKKAIVEKSAFLKVAQTRLDERTRRPNIELCRDMAQLRLVNEVYEVDDTIQTLQQRLRDAEDTLQSLAHTKATLEHDLAVKANSLYIDQDKCMSMRRSFPSTLRLVGFC
Protein: Diabetes and obesity regulated, isoform C (Q8IRB4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, autophagosome {ECO:0000256|ARBA:ARBA00004419}. Nucleus, nuclear body {ECO:0000256|ARBA:ARBA00034306}.
Interaction partners:
Sequence:
MAKSMSKKSNNEEDDSLPRSDSEEELSVVEVSQPRGGSNNASSPMVTVATGTAFNCRRRQGVNSCSLYSGPRPQQQRNYLQRSRVSRPLSISTLSPPRSVPALGAGDHDTLTQSLYVASPSGSDQGQDHGQGANVLMEESCMSVYHSIRSTQEGTDSFVNLDLGVSTEVPQQREEPEPEAEPQDQRQALQEQQRAPNARFDSHAAVQLKQQTLARQSQKSKNKKEHQQLCRSAIKRANKVRDFQAKANRPRRSEMQHCKLVSGANNNRSKCCY
Protein: Bcl-2-interacting killer (Apoptosis inducer NBK) (Bik-like killer protein) (O70337)
Organism: Mus musculus (Mouse)
Function: Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity.
Subcellular location: Endomembrane system {ECO:0000250|UniProtKB:Q13323}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:9525867}; Single-pass membrane protein {ECO:0000255}. Note=Around the nuclear envelope, and in cytoplasmic membranes. {ECO:0000250|UniProtKB:Q13323}.
Interaction partners:
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- Bcl-2-like protein 2
- Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
- Phorbol-12-myristate-13-acetate-induced protein 1
- Bcl-2-like protein 11
- Activator of apoptosis harakiri
- Bcl-2-binding component 3
- Bcl-2-related protein A1
- Bcl-2 homologous antagonist/killer
Sequence:
MSEARLMARDVIKTVPHDQVPQPPVASETPSMKEPVRDVDLMECVEGRNQVALRLACIGDEMDLCLRSPRLVQLPGIAIHRLAVTYSRTGVRGIFRSLIRSLTNLRENIWSWRVLTPGAWVSPDQDPGQLFPMVLLVFLLLGGAWYLQLQ
Protein: Plexin-A2 (A0A2R8QPJ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Sema domain, immunoglobulin domain
- Neuropilin-1a
- Sema domain, transmembrane domain
- Sema domain, immunoglobulin domain
- Semaphorin-2A
- Sema domain, transmembrane domain
- Semaphorin-3D
- Sema domain, seven thrombospondin repeats
- Semaphorin 7A
- Semaphorin-3aa
Sequence:
MGGQQDSQRTLKQSPGQGFTLSFTCWLLVLILPVVCCEQSFTTFYPERREWAFNHLTVHKTTGALYIGAVNRVYKLSGNLTLLVSHDTGPEDDNKACYPPLIVQPCSEPLISTNNINKLLLIDYSQNRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNQTGTMYGVIVPSQGKDGTLFIGTAVDGKQDYFPTISSRKLPRDPESSAMLDYELHTDFVSSLIKIPSDTLALVSHFDIYYIYGFASGNFVYFLTVQPETPENSMSSSGPSNDLFYTSRIVRLCKDDHKFHSYVSLPIGCVRNRVEYRLLQAAYLGKPGRVFAASLNISAQDDVLFAVFSKGQKQYHHPPDDSALCVFSIRDINARIKERMQSCYQGEGNLELNWLLGKDVPCTKAPVPIDDSFCGLDINQPLGGSQLVTGHTLYTESRDRMTSVTSYVYNGFCVAFVGTKSGRLKKIRVDGPPQGGVQYETLSVIKDGNSILRDMAFSLDNSYIYVMSERQVTRVPIESCEQYSTCGECLSSGDPHCGWCVLHNICSQRDRCERANEPYRFAATLNQCVKATVYPDSIAVSEPSVPLLVKVTDVPDLSAGITCSFGNLTEVEGRVNGNQILCISPAAKDVPIIPADQDWSGVELRLNSKETGQMLISTEVKFYNCSVHQLCLSCVTSSFRCHWCKYRNLCTHDPSSCSFQEGRVNASEDCPQLVRSEEILIPAGEVKPITLKARNLPQPQSGQRGYECVLHIQGVSHRVTALRFNSSSVQCQNSSYLYEGMRISELPVDFSVVWNGNFIIDNPENIKVHLYKCGAQRDSCGVCLKAERKFQCGWCSMEGRCTLRQHCPMTNPYTSRWLHLASTNVKCTNPRITEVTPVAGPPEGGTRVTIRGVNLGLSFSDMVNNVQVAGVQCTPQENGYIIAEQIVCEMDAAPVDSKAGPVHLCVGECKPELQTRSSQLYSFVMPSVTGLSPSRGPESGGTKVTIMGENLGAGSSVTVLFGNQTCEFYERTMTEIVCYSAPSLTGVGSVQISVSVDRAQVRDILAFEYIDDPTVQRIEPEWSIASGHTPLVVTGTNLDVIQEPRIRIKYGGRESVNVCKVLNTTTMSCFAPSLTAEYRPGLDSVKHADEFGFIFNNVQALLVYNNTNFMYYPNPFFEPLSTNGVLEQKPGSPIILKGKNLVPSAAGGVKLNYTVLIGETPCSVTVSESQLLCEPPNLTGQYKIMVQVGGLHVSPGSVNILSDSLLTLPAIVSIAAGGGLLLIIVILVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRAGIPYLDYRTYAMRVLFPGIEDHPVLRELEVSGNGQLCVEKALKLFAQLINNKVFLLTFIRTLEMQRSFSMRDRGNVASLIMTALQGRLEYATDVLKHLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLILNCVNPENENSPEIPVKVLNCDTITQVKEKILDAVYKNMPYSQRPKAVDMDLEWRQGRMARVVLQDEDITTKIENDWKRLNTLMHYQVSDRCVVALVPKQTSSYNIPPTTSISRTSISRYDSTFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADKHGIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKNWVERYYADISRLPAISDQDMNAYLAEQARLHSSEFNMLSALNEIYSYISKYSEEITAALDQDETAKKQRLAYKVEQLIAAMSLES
Protein: Putative cysteine transferase (Q83XN4)
Organism: Streptantibioticus cattleyicolor (Streptomyces cattleya)
Interaction partners:
Sequence:
MDPEAGSRARGLKGVHRVSANSGGIGGVPGPHNGLTDVPGVRVGHAGRTGDGWLTGVTVVLAPPGGAVAAVDVRGGGPGTRETDALDPRNLVQTIDAVVLTGGSAFGLDAAGGVAAWLEEQGRGFPVGADPSQVVPVVPAAALFDLGRGGTWRARPDAALGRAAVEAAAARPEGDPVEQGGVGAGTGAVVGGLKGGIGTASVVLDSGATVAALAAVNAAGSAVDPATGVLYGARTGLPGEFAGYGVPDAIGADTHARARARLAEAAEETARRRAGGAATLNTTLAVVATDATLTRAQAQKLAGTAHDGLARAVRPVHLLSDGDTVFALSTGRRPLLPDRPDATAARAFGVHLEAGALNEVLAAGADVLTRAVVHAVLAATGVDTPGGVHPSYRELYARP
Protein: Autophagy-related protein 8c (Autophagy-related ubiquitin-like modifier ATG8c) (AtAPG8c) (Protein autophagy 8c) (Q8S927)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.
Subcellular location: Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P38182}; Lipid-anchor {ECO:0000250|UniProtKB:P38182}. Vacuole membrane {ECO:0000250|UniProtKB:P38182}; Lipid-anchor {ECO:0000250|UniProtKB:P38182}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8LEM4}.
Interaction partners:
- Protein NBR1 homolog
- Autophagy-related protein 3
- Ubiquitin-like modifier-activating enzyme atg7
- Cysteine protease ATG4b
- Cysteine protease ATG4a
- Autophagy protein 5
- Serine/threonine-protein kinase ATG1c
- Autophagy-related protein 18b
- Ubiquitin-like protein ATG12A
- Serine/threonine-protein kinase ATG1t
Sequence:
MANSSFKLEHPLERRQIESSRIREKYPDRIPVIVERAERSDVPNIDKKKYLVPADLTVGQFVYVVRKRIKLSAEKAIFVFVKNTLPPTAAMMSAIYDENKDEDGFLYMTYSGENTFGLV
Protein: Cytochrome P450 2C37 (EC 1.14.14.1) (CYPIIC37) (P56654)
Organism: Mus musculus (Mouse)
Function: A cytochrome P450 monooxygenase that metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to primarily produce 12-hydroxyeicosatetraenoic acid (12-HETE). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 2C50
- Cytochrome P450 2C54
- Cytochrome P450 1A2
- Cytochrome P450 3A25
- UDP-glucuronosyltransferase
- Cytochrome P450 2E1
- Epoxide hydrolase 1
- Estradiol 17 beta-dehydrogenase 5
- Cytochrome P450 2U1
- Carboxylesterase 1C
Sequence:
MDPILVLVLTLSCLFLLSLWRQSSERGKLPPGPTPLPIIGNILQIDVKDICQSFTNLSKVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRFPVFDKATNGMGLAFSKGNVWKNTRRFSLMTLRNLGMGKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLMEKLNEITKILSSPWLQICNTYPALLDYCPGSHKQFFKNYASIKNFLLEKIKEHEESLDVTIPRDFIDYFLINGGQEDGNQPLQNRLEHLAITVTDLFSAGTETTSTTLRYAILLLLKYPHVTAKVQEEIEHVIGKHRSPCMQDRSRMPYTDAMIHEVQRFIDLIPNSLPHEVTSDIKFRNYFIPKGTTVITSLSSVLHDSTEFPNPEKFDPGHFLDENGKFKKSDYFIPFSTGKRICAGEGLARMELFLFLTSILQNFNLKPLVHPKDIDVTPMLIGLASVPPAFQLCFIPS
Protein: Uncharacterized protein, isoform B (A0A0B4LH29)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glycogen [starch] synthase
- FI19480p1
- Major facilitator superfamily
- Uncharacterized protein, isoform M
- Uncharacterized protein, isoform A
- glycogenin glucosyltransferase
- DNA polymerase delta subunit 2
- DNA polymerase delta catalytic subunit
- DNA polymerase zeta catalytic subunit
- DNA polymerase zeta subunit 2
Sequence:
MHPHTTELLTSADIEDGKVEFDKATGATTTYKVIEGGYEVITTSPQPNGTIKTQVRTFWDPKPVSEEDLKKEQENKKLVQKRLGKEIRIDERTTMLTRAIEGGYEEVYTTINEDGTRSSRTKTFYDSVPTEVDEKTAAKLNKNKKNVTRKSSVDSTDSTESSRRIVQKQQKNLVQNYDEQTNSTTTSERRVSVTQNIEITENNRTVRKNSLQEQNVKAITTTSNTSSSDKKQKKKPKSSAPPPPADFFQNDTTSVASKRVPGGVEYTYSTQLDSGKTITTSKTVYEEEEVELTEEEIRQYKKTLKDAEKHKNVSTTKKLKSESGTKKIVPSENPGDVTTVETIKIEGGTEYHYTTVTSEGIVKKAVKTVYDPVPSQKSNPDDTDEEEIIEEYEEEIIEPGEKNVKTIETVKQLPSKFEEEVTITHERKEKKVKKSMVISQ
Protein: glutaminase (EC 3.5.1.2) (Q66V97)
Organism: Aspergillus oryzae (Yellow koji mold)
Interaction partners:
Sequence:
MKSPIPDYLRQVLEKARPDDSGQLANYIDVLAKADPSKMAIALSTVDGNLYSAGDDEVEFSIQSISKAFVYAIAIEDAGLPRVLEKIGVEPSGDAFNKLSLQPGTNRPMNPMINAGAIAAHTLVAGESASAEERVDHILKVLSKLAGRQLKVDEEVYEAELKDANRNMAIGYMLKAAGIISCDPQDAVRGYIRQGSITTNVRDLAMMAATLANAGVNPITGEEIMPHQSARQVLSVMTTCGMYDAAGDWVSRVGMPAKSGVAGGIIGALPGQVGIAVFSPKLDERGNSFRGVKMFEQLSSEMGLHMMDISQVGRATVRTWTLTIAGGAKQPDEREQEVPVFGLRGAVRFAGSERLTRAIVRELTPPNPDDPGSGRHADASAVIFSLKDTYSLNYVALRIISEDMRRLLAADKNVVVIDPVKVLKIDGNPAFKEKSPCVVNDEAEARRYIGGQGCRAVSHSDEFY
Protein: Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD28 and CTLA-4-like protein) (CCLP) (CD28-related protein 1) (CRP-1) (CD antigen CD278) (Q9WVS0)
Organism: Mus musculus (Mouse)
Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9Y6W8}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- ICOS ligand
- CD40 ligand
- T-lymphocyte activation antigen CD80
- T-lymphocyte activation antigen CD86
- Cytotoxic T-lymphocyte protein 4
- Programmed cell death 1 ligand 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Tumor necrosis factor receptor superfamily member 5
- Programmed cell death 1 ligand 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Sequence:
MKPYFCRVFVFCFLIRLLTGEINGSADHRMFSFHNGGVQISCKYPETVQQLKMRLFREREVLCELTKTKGSGNAVSIKNPMLCLYHLSNNSVSFFLNNPDSSQGSYYFCSLSIFDPPPFQERNLSGGYLHIYESQLCCQLKLWLPVGCAAFVVVLLFGCILIIWFSKKKYGSSVHDPNSEYMFMAAVNTNKKSRLAGVTS
Protein: Cyclin-dependent kinase-like 5 (E2E1S0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSTKRKPYHVESSTLSNRSQSTKGGALQTHHRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSSTRSQQNRHSFMESSQSKAGTLQPSEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETNTSRYFPSSCLDLNSPTSPTPTRHTDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGIDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARPSVKESSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSDSSSGTNHSKRQPGFDPWKSPENISHSDQLKEKEKQGFFRSMKKKKKKTQTVPNTDGPDLLTLQKAIHSSSTASSRPKEWRPEKLSDLQTQIPPPTGFLALSPRGPTGCINVELPRLLWRDKREDQSPNLPLTSIC
Protein: Glyceraldehyde-3-phosphate dehydrogenase 1 (GAPDH 1) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) (PL-insensitive glyceraldehyde-3-phosphate dehydrogenase) (Q82IZ2)
Organism: Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MTVRVGINGFGRIGRNVFRAAATRGADLEIVAVNDLGDVATMAHLLAYDSILGRFPEEVTAEPGAIRAGDTTVKVLAERDPAALPWGDLGVDVVIESTGIFTDAAKARAHVDGGAKKVIIAAPASNEDVTVVLGVNQDAYDPERHTIISNASCTTNCLGVLAKVLHDAVGIESGMMTTVHAYTQDQNLQDAPHKDLRRARAAGLNIVPTSSGAAKAIGLVLPELQGRLDAFALRVPVPTGSVTDLTVTASRSTTVEEVKEAYAKAAAGAYKGLLSYTEAPIVSTDIAGDPASCVFDAELTRVLGSQVKVVGWYDNEWGYSNRLIDLALLVGDTL
Protein: Protein SUPPRESSOR OF GENE SILENCING 3 (SlSGS3) (A5YVF1)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Required for post-transcriptional gene silencing and natural virus resistance.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:18165314}. Note=Accumulates in inclusion bodies in the cell periphery. May interact with the ER network from the perinuclear region out to the cell periphery (By similarity). {ECO:0000250}.
Interaction partners:
- AGO7
- ABC transporter E family member 1
- ABC transporter E family member 2
- Protein DCL, chloroplastic
- Tr-type G domain-containing protein
- GTP-eEF1A C-terminal domain-containing protein
- Translation elongation factor EFTu/EF1A C-terminal domain-containing protein
- RNA-dependent RNA polymerase
- Uncharacterized protein
- AGO5
Sequence:
MSFSKWGGKPSNSSEKQKASSTPTVEEINRGVGDIGLNSEQNEGWEVYARKPKNKGGSSAGKQWAPQNPSPKAWGNQNTKAWGHPDVGKKSGTRNNAGSGRGSGNNWSTPSDPQKLARPHLYDGGFPSSAPVPPALKNGWDWSSRVASAHPKDNSQVAAAADDDKASEHDAEDNELDFLDESDDDLHSDDFDSDVGEMSYETRKKNPWFNQLFHSLDSLTVTEINEPERQWHCPACKGGPGAIEWFTGLQSLMTHAKTKGLRVKIHRELAELLEEDLRQRGTSVVPPGEVYGRWGGMEFKDKEIVWPPMVIIMNTRLDKDENDKWIGMGNQELLEYFSSYAAVKARHSYGPQGHRGMSLLIFEASAVGYIEADRLSEHFSENGRNRDAWERRSARFYPGGKRLLYGYMADKKDIDNFNQHSAGKSKLKFEMRSYKEAVWNPAKQMREDNQQLIWFKNKAAKHQMQAKALEESLSLVSEKHRQTLEENKIVRLKTKMHHEQIKEEMEFQEQFFKDQIKIIHDARTAREDNFEKTQQEQREMVKQSNANTASVEDHRVRAEKVAKFIKLQDKEMEEFVEERENLMRTHDDRIAALRRKYWEEEVELERKFDLELSKLMEKYSPKQSDEVNSSGTM
Protein: Phytochrome A type 3 (AP3) (P06593)
Organism: Avena sativa (Oat)
Function: Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc. It also controls the expression of its own gene(s) in a negative feedback fashion.
Interaction partners:
Sequence:
MSSSRPASSSSSRNRQSSQARVLAQTTLDAELNAEYEESGDSFDYSKLVEAQRDGPPVQQGRSEKVIAYLQHIQKGKLIQTFGCLLALDEKSFNVIAFSENAPEMLTTVSHAVPSVDDPPRLGIGTNVRSLFSDQGATALHKALGFADVSLLNPILVQCKTSGKPFYAIVHRATGCLVVDFEPVKPTEFPATAAGALQSYKLAAKAISKIQSLPGGSMEVLCNTVVKEVFDLTGYDRVMAYKFHEDDHGEVFSEITKPGLEPYLGLHYPATDIPQAARLLFMKNKVRMICDCRARSIKVIEAEALPFDISLCGSALRAPHSCHLQYMENMNSIASLVMAVVVNENEEDDEAESEQPAQQQKKKKLWGLLVCHHESPRYVPFPLRYACEFLAQVFAVHVNREFELEKQLREKNILKMQTMLSDMLFREASPLTIVSGTPNIMDLVKCDGAALLYGGKVWRLRNAPTESQIHDIAFWLSDVHRDSTGLSTDSLHDAGYPGAAALGDMICGMAVAKINSKDILFWFRSHTAAEIRWGGAKNDPSDMDDSRRMHPRLSFKAFLEVVKMKSLPWSDYEMDAIHSLQLILRGTLNDASKPKREASLDNQIGDLKLDGLAELQAVTSEMVRLMETATVPILAVDGNGLVNGWNQKAAELTGLRVDDAIGRHILTLVEDSSVPVVQRMLYLALQGKEEKEVRFEVKTHGPKRDDGPVILVVNACASRDLHDHVVGVCFVAQDMTVHKLVMDKFTRVEGDYKAIIHNPNPLIPPIFGADEFGWCSEWNAAMTKLTGWNRDEVLDKMLLGEVFDSSNASCPLKNRDAFVSLCVLINSALAGEETEKAPFGFFDRSGKYIECLLSANRKENEGGLITGVFCFIHVASHELQHALQVQQASEQTSLKRLKAFSYMRHAINNPLSGMLYSRKALKNTDLNEEQMKQIHVGDNCHHQINKILADLDQDSITEKSSCLDLEMAEFLLQDVVVAAVSQVLITCQGKGIRISCNLPERFMKQSVYGDGVRLQQILSDFLFISVKFSPVGGSVEISSKLTKNSIGENLHLIDLELRIKHQGLGVPAELMAQMFEEDNKEQSEEGLSLLVSRNLLRLMNGDVRHLREAGVSTFIITAELASAPTAMGQ
Protein: dihydrofolate reductase (EC 1.5.1.3) (Q76S40)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MDPTLYCVVAVDTKLGIGKNRCLPWPALRGDMRRFRQLTTDCAPGKQNMVVMGRRTWLSIPAGCRPLAGRINVVLSRTLETPPPGAHFLASSLDAALGLARSPELAQQIDKVWVIGGGDLYREALTGPWPVRLFLTRVLHDFACDVFLSHDSLAAYARVNPKPGEQERVFQERGIFYMFETYIKVTQSSDTALPDLERPRPATPPFSETS
Protein: LP02193p (Q8MSU1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLASPSPSKSSLSASREYIDLGSSGSLDRCSVNQPVPAAKDKEPHQQLYEICQGQGAGQDEDEAQQAITFTHEVFIDCPYADLPAGHLSLQRSTKYGQLQRIVPKRLFFDQTRKCYCGILNDWMLCYADGPTACRPSSTLYLKSSSIEIEHFGEGKRRDICFQITTDDPNKKFVYQANNEVDAKEWIHAIEAAIRGDAGAHSALKTPPPRKLPTPPVQKKSTYTAADIIYEEPSPVYGLIDSSSMVLPKLPEKSNSPSALARRFEYDVPKCPAQPLQDTSSRVASVSGELESLGLLNEGDIKVQPQPSSLHGSISLDFQARVKTVHSELSTQLSAAGPSPDRLKKAAKKSYSNGSEPEMLSPLTSPVQTPTKDQKKQRKSTTSPQSSPVSKDCDKLARNWFLSRLNKSTGLKATNTGSASPTNAKCKQSEKENLLTEAELGEGYDASPGDRYHGLPGSPPTSPCLKAEAKSKVNMIINQFESSGHLSTMFSVEALAANALASLTSFCESDGCNNYEPIMPLATTPSSFLKKV
Protein: Naphthalene 1,2-dioxygenase system, small oxygenase component (ISP NAP) (Naphthalene 1,2-dioxygenase ISP beta) (Naphthalene 1,2-dioxygenase subunit beta) (ND subunit beta) (NDO subunit betaa) (O52383)
Organism: Ralstonia sp
Function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. Also able to use styrene as substrate. The beta subunit seems to have a structural role in the holoenzyme.
Interaction partners:
Sequence:
MMINTQEDKLVSAHDAEEFHRFFVGHDSDLQQEVTTLLTREAHLLDIQAYNAWLEHCVAPEIKYQVISREFRSTSERRYQLNDAVNIYNENYQHLKVRVEHQMDPQNWANSPKIRFTRFVTNVTAAKDKIVPDLLHVRSNLILHRARRGNQVDVFYATREDKWKRIEGGGIQLVERLVDYPERILQTHNLMTFL
Protein: Zinc finger CCCH domain-containing protein 2 (OsC3H2) (Protein DELAY OF THE ONSET OF SENESCENCE) (OsDOS) (Q9FU27)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in leaf senescence delay. May repress jasmonic acid (JA) signaling role in promoting leaf senescence. May regulate panicle development and pollination/fertilization process.
Subcellular location: Nucleus {ECO:0000269|PubMed:16778011}.
Interaction partners:
Sequence:
MMMMGEGVSSVPPWSHLPVSGVDVLGGGGGGGDEMTPYVIAALRDYLPANDVGVGADEEEEAAAMAAAVDAYACDEFRMYEFKVRRCARGRSHDWTECPFAHPGEKARRRDPRKYHYSGTACPDFRKGGCKRGDACEYAHGVFECWLHPARYRTQPCKDGTACRRRVCFFAHTPDQLRVLPAQQSSPRSVASSPLAESYDGSPLRRQAFESYLTKTIMSSSPTSTLMSPPKSPPSESPPLSPDGAAAIRRGSWPGVGSPVNDVLASFRQLRLNKVKSSPSGGWSYPSSSAVYGSPKAATGLYSLPTTPLASTATVTTASSFMPNLEPLDLGLIGDEEPVQRVESGRALREKVFERLSRDGAISGDATAFATAGVGLDVDWVSDLIN
Protein: Liposome tubulation protein MamY (Q2W8K3)
Organism: Paramagnetospirillum magneticum (strain ATCC 700264 / AMB-1) (Magnetospirillum magneticum)
Function: Causes tubulation when added to magnetosome-derived liposomes, binds liposomes; may be involved in constriction of the cell inner membrane to form mature magnetosomes. Binds preferentially to cardiolipin, a component of bacterial membranes, with very poor to no binding of other tested (phospho)lipids. Addition of cardiolipin to magnetosome-derived lipids increases tubulation. May function with MamX, MamZ amd Mms6 (By similarity).
Subcellular location: Magnetosome membrane {ECO:0000269|PubMed:20345667}; Multi-pass membrane protein {ECO:0000255}. Note=Primarily associated with immature magnetosomes with small magnetite crystals, but longer than the usual magnetosome chain. {ECO:0000269|PubMed:20345667, ECO:0000269|PubMed:27481925}.
Interaction partners:
- Magnetosome protein MamX
- Magnetosome protein MamZ
- Cell division protein FtsZ
Sequence:
MAIAAIMGDVLMLMGFNKAAFGKLNSASRAALIGAVIWAVLSIVYLTIFNGWKNLFTMLPHEFFIVLLSIALPIGLTVLILMLSRIVKSVDTLKSEVTTLSRNDVSSEGSVAMLADLFREHRAAIAAQVEAQVEATTQLIRLNQEGRALAAPAQASGTDEAMTLLAQLFREHREAVAAQLEAQASATAQLVQVTRDSRDGIVDELRSQRVLSQEITQELSQITQSRTVAPAPPGLDPSQRIDRMRALAEVLGLALNDLSMTATQVLTEHLNAAHGDRDGTRKFISTLTTAYFAGDKNVFFRSLVQEAVNRSEQLRRCAEDTESVRQQISKILREAREIRSLVAACDPNDLVRIVFEDGELWALEKALAEHFLIDGSPVWTETAPDSGMD
Protein: N-sulfoglucosamine sulfohydrolase (sulfamidase) (B1ATE0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MHCPGLACCTILLVLGLCGAHSRNVLLIVADDGGFESGVYNNTAIATPHLDALSRHSLIFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVQSLPLLLNQAGVRTGIIGKKHVGPETVYPFDFAFTEENSSVMQVGRNITRIKQLVQKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGYIPDWTPQIYDPQDVMVPYFVPDTPAARADLAAQYTTIGRMDQERQDQPVLARYSRAFAGVISRAPTALGPGQRRLREPSRPHPYHPGLVLHPVPQLCHLWLKDDPAHRPIPPAGAGGRAPLGHCLQQPEPPRGHHVLPDALGVPPELPPHSQPELQDAISHRPRFLCLADLPGPPEPNHHRPAHGLVQGPPPLLLPGTLGTLRHQPGPSRDTEPGR