wanglab/gogpt-training-data huggingface dataset:
Protein: Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1) (Q03206)
Organism: Caenorhabditis elegans
Function: Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. May regulate these 2 processes by activating pak-1 and/or max-2. Plays a role, probably via mig-10, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt-1. Regulates mig-10 asymmetric distribution in HSN neurons. During the dorso-ventral axonal guidance and outgrowth of VD neurons, required together with mig-2 to inhibit growth cone filopodial protrusion mediated by netrin guidance cue unc-6 and its receptors unc-5 and unc-40. Specifically, regulates growth cone filopodial protrusion polarity, and thus migration, by promoting F-actin polarization and, together with mig-2, by restricting plus-end microtubule accumulation in the growth cone. Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration. During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation, probably by activating max-2. Furthermore, plays a role in distal tip cell polarity and migration by negatively regulating the unc-6/Netrin receptor unc-5. May be involved in signal transduction during cell migration. May be involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27415421, ECO:0000269|PubMed:8824291}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:27415421, ECO:0000269|PubMed:8824291}. Note=Co-localizes with pak-1 and cdc-42 at hypodermal cell boundaries during embryo elongation. {ECO:0000269|PubMed:8824291}.
Interaction partners:
- CED-5
- CRAL-TRIO domain-containing protein
- Serine/threonine-protein kinase pak-1
- Cell death abnormality protein 12
- DH domain-containing protein
- Serine/threonine-protein kinase max-2
- Wiskott-Aldrich syndrome protein family member
- Cell death abnormality protein 2
- Probable rho GDP-dissociation inhibitor
- Netrin receptor unc-40
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGRPINLGLWDTAGQEDYDRLRPLSYPQTDVFLVCFALNNPASFENVRAKWYPEVSHHCPNTPIILVGTKADLREDRDTVERLRERRLQPVSQTQGYVMAKEIKAVKYLECSALTQRGLKQVFDEAIRAVLTPPQRAKKSKCTVL
Protein: Exocrine gland secreted peptide 6 (A0A3B2WD20)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MEEAIPAKTKDYESNFHVSVMTSLPMMIFLVILLLPSMPTEGRVLTQTQEQSTISADQKTNQETFLDKIESKGNPGNPSIKEAIEMFSCAFDQDKTLLEDQSNSDQPSLNLSKLMTTLNKCGAQKYKVAEYVPEDGLAGHEWPEGSLVLRLLDNPV
Protein: Aspartate/alanine antiporter (Q8L3K8)
Organism: Tetragenococcus halophilus (Pediococcus halophilus)
Function: Catalyzes the electrogenic exchange of aspartate with alanine.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MNAIGNFLVGTPVFTIFICLALGYLLGKLKIGSFTLGATVGVLIVALLIGQLGVFPRDTLLGDIFFDFFMFAIGYRVGPSFISSMKKFGAKIVYATLIFLVSAFIVAYACFKMFHIGPGIAAGIIAGGLTQSAVIGSSLETISKLPISDHLKTLYSNQIPIVYTLTYVFGTIGVLIFLRDIMPKLMHIDLKKQAVKTAKELDMIPVPVIVASTHFYTINDGSSLIGQTLGTVNTKFAKGLVAAGLNDSADMASVINAGDVLAISGGIDEIGRAVQEFNLLEVTGKTKAYVSKQVVLKKNFSADVLKNAQDKGVLVATLAGDVMDPAQFSTLKPAESVTLVGQKDAVSEVQSQLGRLRAAENIINYSWFALGIALSAALGIVGTKVSGVPIALGGGTASLIVGLVQSIYRDKHAHMDTIPDSLLEFFQSIGLNLFIATVGLSAAKTFISAIQSMGISVLLIGAVISILPHIITFVICYYLMKMEPISIIGAQTGADTLSAALNDVSERVGSDASPFFAAAVAPAYAIGNIFLTLMGPIFIVLLS
Protein: Protein YOP1 (J9VRC5)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362006}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362006}.
Interaction partners:
Sequence:
MAAQSEQIKNNFLNNPYAQQVLNVANGQVSALDAELNKYPILRQLEQQTKVPKAYGVIALGFSSVLLIFFNMFGLAQPISNLIGWALPAYLSILAIESPQTNDDKQWLTYWVVFGSLNLVESMGLRAVLYWVPMYFVFKTLFTIWLMLPATRGAEILYFHFLRPMVGNVKSRSQASFGTSDPLAKEHSFNPAGTTAPSSFAHEKTL
Protein: Trafficking protein particle complex subunit 11 C-terminal domain-containing protein (Q38EF2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Trafficking protein particle complex subunit
- Transport protein particle
- Trafficking protein particle complex subunit
- COP9 signalosome complex subunit 4
- Uncharacterized protein
- Transport protein particle
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 11 domain-containing protein
- Trafficking protein particle complex subunit 11 domain-containing protein
Sequence:
MSKDGVSPSFNGAKGEKDGGVSVFSATDYMPAILANPLTVRAAVLRKPELAQSSLPELVEEGDILFDVLANPLHHPLVTVKQSGDPLVSQRRSEAARLAMQGVSSVLSLPSVVGKHFVGQPFRAILSFHNAAAYPLTTAVIRINIVTPSVRHVTLVNHECPAIEARGNVSFTVEHLLSSPGQYTLSVVATCVDVVKEQKRLTWASTIEVEHAIIEVRRSLRLLPASFGRGGDNDRQLQEKGPSASVGSSDSFFPSRRYALTVCLQNVATVPIVVENVELRVGETFQVLSSSKSAVANQVTTGPHSESNSAGEAEECDISGANVRHLSGGIEVVDDVFLSPKDKRRYFFEFTMRPEAVRSLMLGQMPLAEQVGAVAPRIVDVGYVVWDWRRPNGDSGRDGSGVVQLELPRHPMLELHVTNMEPTSPQVGTPVKFECAIVNHHTQQTVDLALRVRPELLAPAFVYAGPLAVPVGVVEPNGMTTLTLTLVPWRTGWVSLNGGLELCDTRAPGCVLWPPLPQVSPGKSDRLREPYPPVICELLVC
Protein: Heme A synthase COX15 (HAS) (EC 1.17.99.9) (Cytochrome c oxidase assembly protein COX15) (Q9FKT8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the biosynthesis of heme A.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P40086}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protoheme IX farnesyltransferase, mitochondrial
- Cytochrome c oxidase assembly protein COX11
- Surfeit locus protein 1
- Surfeit locus protein 1-like
- Cytochrome c oxidase subunit 1
- Protein SCO1 homolog 2, mitochondrial
- Protein SCO1 homolog 1, mitochondrial
- Pentatricopeptide repeat-containing protein At3g48810
- Cytochrome c oxidase copper chaperone 1
- Non-specific lipid transfer protein GPI-anchored 9
Sequence:
MFRAVGSALKRNKEAFNGIARGFTTSSHRVFTSNITAASVTSASSSPLAGNSFYGLRSLLKGQNASMFRRMSTVASISSESKEGLKLLVTGGPQAQKWVGIWLFGSAAWVFSMVVLGGVTRLTRSGLSMTDWKFTGEFPPLSDEAWAKEFEKYKQSPEYKRVNKGMNLEDFKFIYWMEYAHRMWGRGLGIMFALPFSYFLRKGYITLRLGVQLSGLFALGAGQGFIGWWMVKSGLEEPPSEYSQPRVSPYRLAAHLTSAFAIYCGLFWTALSVVMPEPPAESLAWVRGAAKVKKLALPVSLIVGITAISGAFVAGNDAGRAFNTFPKMGDTWIPDNIFEMKPLLRNFFENTATVQLDHRLLATTTLIAIGTMWWFTRKLDIHPAVKALIGSTVGMTAVQVTLGVSTLLSYVPVSLGSAHQAGALTLLTLMLLLNHTLRRPSPSLLKSLPQVAKSNFS
Protein: 23S rRNA (uracil-C(5))-methyltransferase RlmCD (EC 2.1.1.189) (EC 2.1.1.190) (23S rRNA (uracil(1939)-C(5))-methyltransferase) (23S rRNA (uracil(747)-C(5))-methyltransferase) (O31503)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the formation of 5-methyl-uridine at positions 747 (m5U747) and 1939 (m5U1939) in 23S rRNA.
Interaction partners:
- dTTP/UTP pyrophosphatase
- DNA methyltransferase A
Sequence:
MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEEKAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQKQVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDIIDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIVFITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLIGDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAKKVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRKGCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVECCVLIKLKE
Protein: Zcf7p (A0A1D8PJ96)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Zcf20p
Sequence:
MNNHNFIFNSSGDNNNNNNDDNNYYSHTNNSDNLLALGQGDSMSTFNSASPTSSISPSSNNPGLSNNSNQAPSESVLSNFFHTTNNSNPSLKKLTNRHTTSKKPKRKRATNIRACDTCAAKKVKCDANRPCGQCRTNNLECTHTRERKKTGPKTPTQKALESINNLTEVIEINANGKRKNLSRTGSNNSAVTQCSSNELTHDRTETENSNQPLSSRNSASPPISTGSSIKQCDTLKQIVGDNGNGDGNGTTDNNSVHQQNLEQLQGKLSLNDTSTSKTKEFATSPMAVPSATTIEDYIVTPFHLMENINLIGEEPSILELVRPLTVDSVILNYVRLVEFLVSNYPDSRDGNYQNNPRYQELNLIDHHDNSLYLSTLLIILTLNQIIAEVLIKLKKQKFKKFVRYPKKYLLSRPFKNFKNLCHFKVLEIFTLIEKNFIXXXXXNSPKQGP
Protein: Phosphatidylinositol transfer protein beta isoform (PI-TP-beta) (PtdIns transfer protein beta) (PtdInsTP beta) (Phosphatidylinositol-transfer protein 36 kDa isoform) (PI-TP 36 kda isoform) (Q9TR36)
Organism: Bos taurus (Bovine)
Function: Catalyzes the transfer of phosphatidylinositol, phosphatidylcholine and sphingomyelin between membranes. Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity).
Subcellular location: Golgi apparatus {ECO:0000250|UniProtKB:P53811}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P53812}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P53812}.
Interaction partners:
- PITPNM family member 3
Sequence:
MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEKDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANNPDCPQMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKKGSVRGTSAADV
Protein: FADH(2)-dependent monooxygenase TftD (EC 1.14.14.-) (Chlorophenol-4-monooxygenase component 2) (Two component enzyme D) (O87009)
Organism: Burkholderia cepacia (Pseudomonas cepacia)
Function: Oxygenase component of a two-component system that degrades 2,4,5-trichlorophenol. Uses FADH(2) supplied by TftC to oxidize 2,4,5-trichlorophenol (2,4,5-TCP) to 2,5-dichloro-p-benzoquinone, which is chemically reduced to 2,5-dichloro-p-hydroquinone (2,5-DiCHQ). Then, TftD oxidizes the latter to 5-chloro-2-hydroxy-p-benzoquinone.
Interaction partners:
Sequence:
MRTGKQYLESLNDGRVVWVGNEKIDNVATHPLTRDYAERVAQFYDLHHRPDLQDVLTFVDADGVRRSRQWQDPKDAAGLRVKRKYHETILREIAAGSYGRLPDAHNYTFTTYADDPEVWEKQSIGAEGRNLTQNIHNFLKLLREKDLNCPLNFVDPQTDRSSDAAQARSPNLRIVEKTDDGIIVNGVKAVGTGIAFGDYMHIGCLYRPGIPGEQVIFAAIPTNTPGVTVFCRESTVKNDPAEHPLASQGDELDSTTVFDNVFIPWEQVFHIGNPEHAKLYPQRIFDWVHYHILIRQVLRAELIVGLAILITEHIGTSKLPTVSARVAKLVAFHLAMQAHLIASEETGFHTKGGRYKPNPLIYDFGRAHFLQNQMSVMYELLDLAGRSSLMIPSEGQWDDSQSGQWFVKLNNGPKGNPRERVQIGRVIRDLYLTDWGGRQFMFENFNGTPLFAVFAATMTRDDMSAAGTYGKFASQVCGIEFGGAEPTAYAATADYAKALDKGLAPEPAAAESATS
Protein: Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein) (Q92990)
Organism: Homo sapiens (Human)
Function: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1. Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature. Contributes to the regulation of RPS6KB1 phosphorylation.
Interaction partners:
- E3 ubiquitin-protein ligase RBX1
- Cullin-1
- Cullin-7
- Peptidyl-prolyl cis-trans isomerase FKBP4
- F-box/WD repeat-containing protein 8
- S-phase kinase-associated protein 1
- NLR family CARD domain-containing protein 4
- NACHT, LRR and PYD domains-containing protein 3
- Peptidyl-prolyl cis-trans isomerase FKBP1A
- Cullin-4A
Sequence:
MAVEELQSIIKRCQILEEQDFKEEDFGLFQLAGQRCIEEGHTDQLLEIIQNEKNKVIIKNMGWNLVGPVVRCLLCKDKEDSKRKVYFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQSILLLLQPLQTVIQKLHNKAYSIGLALSTLWNQLSLLPVPYSKEQIQMDDYGLCQCCKALIEFTKPFVEEVIDNKENSLENEKLKDELLKFCFKSLKCPLLTAQFFEQSEEGGNDPFRYFASEIIGFLSAIGHPFPKMIFNHGRKKRTWNYLEFEEEENKQLADSMASLAYLVFVQGIHIDQLPMVLSPLYLLQFNMGHIEVFLQRTEESVISKGLELLENSLLRIEDNSLLYQYLEIKSFLTVPQGLVKVMTLCPIETLRKKSLAMLQLYINKLDSQGKYTLFRCLLNTSNHSGVEAFIIQNIKNQIDMSLKRTRNNKWFTGPQLISLLDLVLFLPEGAETDLLQNSDRIMASLNLLRYLVIKDNENDNQTGLWTELGNIENNFLKPLHIGLNMSKAHYEAEIKNSQEAQKSKDLCSITVSGEEIPNMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKTKSTSEENIGIK
Protein: Dipeptidase 2 (EC 3.4.13.19) (Membrane-bound dipeptidase 2) (MBD-2) (Q8C255)
Organism: Mus musculus (Mouse)
Function: Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4). Hydrolyzes cystinyl-bis-glycine (By similarity).
Subcellular location: Membrane {ECO:0000269|PubMed:12738806}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12738806}.
Interaction partners:
Sequence:
MSLTGLKGHWVLGHGLSVFLLVLLLLGPSQPLIWTQTKPGFSGASTTSSIPRALTKPDISSIPTTPGNPNFPDLRDRARALMQEFPLIDGHNDMPLVLRQFYQNGLQDANLRNFTHGQTSLDRLKDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRICASYSELELVTSVKALNSTQKLACLIGVEGGHSLDNSLAVLRSFYLLGVRYLTLTHTCNTPWAETSSKGVHAFYSSVTGLTSFGEKVVAEMNRLGMMVDLSHVSDAAARRALEVSQAPVIFSHSAARAVCPNARNLPDDLLQLLKKNGGIVMVTFSVGVLPCNPLANVSTVADHFDHIRSVIGSEFIGIGGDYDGTKQFPQGLEDVSTYPVLIEELLRRGWNEQELQGILRGNLLRVFRQVEQVRDKSKWQSPLEDMIPEEQLDSACHSALRPQKQHPEKNQPETPEYHILKFSHSKSSPHIVPSLAIVATLLGLIV
Protein: Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (O88343)
Organism: Mus musculus (Mouse)
Function: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:11171615}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:21317537}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Carbonic anhydrase 2
- S-adenosylhomocysteine hydrolase-like protein 1
- Carbonic anhydrase 4
- Sodium/hydrogen exchanger 3
- Sodium/hydrogen exchanger 1
- Solute carrier family 26 member 6
Sequence:
MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKAGHKEKKEKERISENYSDKSDVENADESSSSILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIADHQIETGLLKPDLKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFSNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPTIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDHNFDYLEFRLWIGLWSAFMCLVLVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSDFKVGYNTHFSCACLPPDPVNLSVSNDTTLAPEDLPTISSTDMYHNVTFDWAYLSKKECVKYGGKLVGNNCDFVPDITLMSFILFLGTYTSSMAMKKFKTSRYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGGNPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPSIKIPMDIMEQQPFLSDNKPLDRERSSTFLERHTSC
Protein: Combover, isoform B (GH01088p) (Q961X4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVHEINPNSDQGEGVVNSTSLEDVALSEMSDNRAQSIQSLHSVLETPTPDTTPSFDELQQRLEASNRNMQHLHDEQAKLLQIQNLAKTHLNEMERLRQQADSLPHNVNGGEAPKYESVQQVQDDMASLVGRMKNLTAFIHNQNELSTVLGDDGPEILAEQEALQEKLESLRTQREDMRNLVDELNSINRAARETARVIKEKEETPTPPPKPEEAAPAAPKERVVPVEYQRNVPIIRQEAANAAQRALHAQAMINQKTADIEALKAQMARLKGMLYTVSQIEESTPSMGSTLERRSEERTSVERELPAEIAQRVFALNDVTSELRAEAASLQKERDRILALKAEIERRKQQAAAAVQMGDDALKRSSLTPTPTPMRQRMTEEEDPSEVDNSLQATPTKEQLRDELRSQCERLRTEYEQKQRELEQRYVASNNTTSEADDEANDDTDSDKYFANVRTASSATLKRAPSANTVVEQRRGQQPNVPPQQAPPPPPPAPPSTLNEDDLNVTLDTLSLGNDSIPSSSNRSQYMPPPMQPVPGMWASHNSGSSWHGQQPVYGQPSSSAGTEFKKLPAAQQGGSSNGSGSNASTDAVLLQQFMQTQQMLINSVCQCNQALWHQQREIDNLNHQLHALQDRFNVVACQDHSFGLRSESVPPPVGPGMGQMPNNLCLGSSRAQSEQLFNFGAHQSAFSNYQRSCHRSGAESHHHQQQQHQAQPFLNNAAPPPPPTHFNNETPLSPPTYRSSPGPIFMNHHNNTIHQNNSNLRTQNQHANNLHSLPEGAAGGGAPGGGITLNNQVPPGNRANNYWDNFRR
Protein: HVA22-like protein e (AtHVA22e) (Q9FED2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein At1g23150
Sequence:
MTKLWTSLSALHSLAGPVVMLLYPLYASVIAIESPSKVDDEQWLAYWILYSFLTLSELILQSLLEWIPIWYTAKLVFVAWLVLPQFRGAAFIYNKVVREQFKKYGILKPKVEHQAE
Protein: Acyltransferase (EC 2.3.1.-) (Q7K1C2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367023}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367023}.
Interaction partners:
- O-acyltransferase
- phosphatidate phosphatase
- Glycerol-3-phosphate acyltransferase 4, isoform D
- RE23632p)
- Acyltransferase
- Acyltransferase
- Diacylglycerol kinase eta
- Diacylglycerol kinase 1
- Eye-specific diacylglycerol kinase
- Diacylglycerol kinase
Sequence:
MKIEWAPLRVPLERRLQILVTAFFTSMLLILLSVSFLLVAGSLIYGGLLVRSLMVTYLAYVFVHHKKTQSVVDGNGWMITRTNLLHRHYRDYFPVELVKTAELPATKNYILASFPHGILGTGIGINMGLEISKWLELFPQVRPKLGTLDQHFHVPFMREVLRCWGLVSVSKEALIRMLSKSNDPKHKDNRDGFTSNAVAILVGGAQEAMDSHPGQYILTLKNRKGFVRMAIRTGSSIVPSFSFGEVDIFDQVANPPNSLLRRFQDFVKKLTGVSPLIPVGRGFFNYTFGFLPFRRRIVQVVGAPIDVVKNEHPDSEYVDKVHGQVIESLEKLFDQYKDKYLENSKSATLVVH
Protein: CG9339-PH (Q6Q4F0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MPYHRGGDASSQADKLSGIVEESDLYEGFAPHVETSEIKTLDFYNLPKQTGKEPALRSYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLDGFYWEMVHQVFGTTELSEKPIMLPAFVDATHCLPYHLTSTGRAVADRIVNVLGYDCPDITYSPVLYPFTSILLHFMSEEEAYICLAGLVGSKEKVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQRICPGLKLERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDNIKNDIGNALIKFCKKIPVSAAKLLHAAFSIRGLSTQYISRIFIKTEMLLKSRSVLTSGSKQLIKSRSSDNLPTSQSQVNIQMMSHTLTIRELFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCNNEVFGAYCSSRWFERNVKDDKGQRQAYFGTGETFLFSLYPERAKYPWVGIEGDKDLGHSSELFMAATPKMITIGGGEGQAIWMDENIRFGKTDSCKTFNNPPLCRPATSRFGCWKSTDSWASKNLLS
Protein: Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a) (P78324)
Organism: Homo sapiens (Human)
Function: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity). Receptor for THBS1. Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Tyrosine-protein phosphatase non-receptor type 11
- Leukocyte surface antigen CD47
- OX-2 membrane glycoprotein
- Signal-regulatory protein gamma
- Triggering receptor expressed on myeloid cells 2
- Tyrosine-protein phosphatase non-receptor type 6
- TYRO protein tyrosine kinase-binding protein
- Tyrosine-protein kinase SYK
- Pulmonary surfactant-associated protein D
- Immunoglobulin lambda-like polypeptide 5
Sequence:
MEPAGPAPGRLGPLLCLLLAASCAWSGVAGEEELQVIQPDKSVLVAAGETATLRCTATSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRIGNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNERNIYIVVGVVCTLLVALLMAALYLVRIRQKKAQGSTSSTRLHEPEKNAREITQDTNDITYADLNLPKGKKPAPQAAEPNNHTEYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK
Protein: Protein BTG3 (rBTG3) (BTG family member 3) (O88677)
Organism: Rattus norvegicus (Rat)
Function: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.
Interaction partners:
- CCR4-NOT transcription complex, subunit 7.
Sequence:
MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTQILQEKYKNHWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACEDSCILYSDLGLPKELTLWVDPCEVCCRYGKKNNAFIVASFENEDENKDEISKKVSRALDKVTSDYHSGSSSSDEDTSKEVEVKPSAVATTPSPVYQISELIFPPLPMWHPLPRKKPGMYRGGGHQSHYPPPVPFAYPSPGRKNKAFRPIPVTWVPPPGMHCDRNHWINPHMLAPH
Protein: Transcription factor bHLH91 (Basic helix-loop-helix protein 91) (AtbHLH91) (bHLH 91) (Transcription factor EN 25) (bHLH transcription factor bHLH091) (Q8GX46)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor DYT1
- Short-chain dehydrogenase reductase ATA1
- Transcription factor MYB35
- Transcription factor MYB80
- ATA20 protein
- Protein EXORDIUM-like 6
- 3-ketoacyl-CoA synthase 7
- Cytochrome P450 703A2
Sequence:
MYEESSCFDPNSMVDNNGGFCAAETTFTVSHQFQPPLGSTTNSFDDDLKLPTMDEFSVFPSVISLPNSETQNQNISNNNHLINQMIQESNWGVSEDNSNFFMNTSHPNTTTTPIPDLLSLLHLPRCSMSLPSSDIMAGSCFTYDPLFHLNLPPQPPLIPSNDYSGYLLGIDTNTTTQRDESNVGDENNNAQFDSGIIEFSKEIRRKGRGKRKNKPFTTERERRCHLNERYEALKLLIPSPSKGDRASILQDGIDYINELRRRVSELKYLVERKRCGGRHKNNEVDDNNNNKNLDDHGNEDDDDDDENMEKKPESDVIDQCSSNNSLRCSWLQRKSKVTEVDVRIVDDEVTIKVVQKKKINCLLLVSKVLDQLQLDLHHVAGGQIGEHYSFLFNTKIYEGSTIYASAIANRVIEVVDKHYMASLPNSNY
Protein: Shavenoid, isoform C (A0A0B4KEL5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRLQSLPLLLLLAVVTLPPATPTSAARPLTHPRARNHYPSEDLAEEPLMPASLLLEELQQTNGQLVNLTRQHDGDTFHTSGLSSACNADTCIGLSSGTASLVRSTGDGSGQGNDGLNPATSSLGGGQMELLTRRLKLQKGRGQVANIDASGETGCTCRCLPYQRAYREDLGICVDDIHECSLSPFVSGSSSEKIPFVFLPLKGQIIYPSREISFASIHTPVCAVTGAQYLGSNGWSDLRNPIDTDYPFRMFRDEGRSFLLWLGEADLRQKMQGRLIVVHLVCRDMTVALNASNHVKGEPLMPPRNVHSPCVAFRVNGSPVKYAHNVPEVFFQPANSTTLASTSDGMTMREYVVIGICSLLLGLIYVASVFLYLYMKKRKRHSSRHSLDNLTNDINYPKNDQVTYGAPFSRVGSIYSSNSMGLGNGNESNTRTSIGSLKEDMGIVKNNPLLQHFPQLSEREHNSGFASDISNSNSECEMEEKIKLSKSPKPSGGTDNAAMDVDDFLQDNECLPAENVAVIDELMSEEKLENLRAMVSGNVRKKLYFNPAYFEPHLLAEPPQAAIEFLQKIREVIAIAKYKMASKRYQPSLNIIPEEQHPESSSSSPMFNIPLQQSLAGKGMGDKRNSIEQWLQSVPNSDATPAPKTLDRPAPPTAKKPSSGSPNKGSLRKEISAPKERPPPPPMQKSKADEGNAKSSSPAPSGPHSSRSTGKSSPEQSPKPKTNVGSTYEGFSAFSVAANVYGFAETGGEIYNNPKFMLADSPAASLRSASSRSKSMKKRSEVLDQFAAANSTPTSLTSFDRQHYNMLRNMKAPEVIYDSLKREFAAHIPTPDYDSTIEKRIKDIYSSTQSSIPSVPTPDYSSLSRKSLKQFQPDSPIYRRKSPQYLIVDYETDSLERLEPSKRKSSHSSSSPSSDVSSQLSPSLSTALPLEEEMEISHTVYDRMNGFRKEGEMKKRLAAKHQHPHPGQQQRQKEAAARIKYDTPFRGSMTIEVEHEPPSDLERTDSDQFEPDTLDRKPKKQSFCDISAWDGHKPIDSDFSQISSLPDLSRQISPAPNQGIKPRTASFILRSSNSFRNLREIYESPLIAQDNIKYEKKVAQTPEEEGRILTLEAKHSRRQRLMETSPTHSVMDITKVNKTTITISSPKPADKAPPTRPKVNQHYCPPLVQSKRPLPPPPPNSSEHQAPDEDAYSLHSEITGTSEFENSCNNTMSSAISATTEERTHAKGSRSPKINAKIPEEDYEGMYNKKINSLRNDYSLTKYLNRRKSQREEVSKAGPDSPKDVAPEPEFGGSNKSVKEVDVAQFDALSISSRSNRSSSHLSERTKEMYRNAGVPVGIAYPQRAASSSGNASAGGNVQTVYRCEIEQAQLTAGMQIAIGLKDRAKKAKDLKNAWRKFVTMAANKFSPSQSPAPTYGSKTAAGFLEDDGIASIIEDAAQSAGMGQPGSQTYYEQRFGQLDSGYMSTDSTELYKRNVYDRYNFKMPCGRGQIIRVDTIEDNEEESGPNDNRFEDLEHMVSPSHSRRSPENNAVVACDLSDAESDKTLTRSHSQTNSQERNVRGSTTTMSSYSSDENGRGRSTCCGSSETDEETNAEDMWESGAESIETHSVLYKMIRKS