wanglab/gogpt-training-data huggingface dataset:
Protein: Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) (Q38CB9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton, spindle pole {ECO:0000256|ARBA:ARBA00004647}.
Interaction partners:
- ATP-dependent protease subunit HslV
- Uncharacterized protein
- Katanin, putative
Sequence:
MDDDVGLQKAIYSSLQSKRTQDAFNRFSRNAPSHGTVRSFPRNGKRNALLREGIMPTVPRSQQVRSTTGWTFSQFGDYTDRPPWVNPLDEESCIPNMPVRLQQPSDRVPGWTLMCSGGRIQRQNAMGSNILFICEEVHYAQNTKIHCNDLLALRTVAPLPQGKNIACFTAQIQSLVSQGRYAMFGMGITPRAGDERQGFCVALVHYDSSGGIFLSVEKWRMTEQDTFERLELLEPMKTLRLIRERVTITLLVSSEHFSLSINGEVVCPTLHAPGVRLGESLPILLATGGKISVREVAVVEGHKPPANKLYGRPPPFTLSPKKSDTNKKGIPIVEEEPLCSSGKAAFPDKVSNRKGKVVDKAVPKDKVLNSVAPCAPPGIAPELLERIEAEIIERSPNVEWDDIAGIPEAKRLLKEAIILPLLVPELFTGVVQPWKGVLLFGPPGTGKTMLARAVATSAKTTFFNISASSLISKYFGESEKIVRSLFHLARHYAPSTIFFDEVDALMSARGGNEHEASRRIKSEMLQQFDGLCTENDKRVLVLATTNRPWDLDEAMRRRLEKRIYIPLPDKAGRLSLLKKQTATLSLDPSVDLEEISDKRTEGFSGADMNLVVRDAAMMPMRRLIADRSPAEIAAMKEGGKMIVSPVTMNDFEDALKKIQPSVSQSSIKQFEKWAEELGSV
Protein: Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) (Q8C7R4)
Organism: Mus musculus (Mouse)
Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34 (By similarity). Essential for embryonic development. Required for UBD/FAT10 conjugation.
Interaction partners:
- Ubiquitin D
- Ubiquitin-conjugating enzyme E2 Z
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-conjugating enzyme E2 N
- Ubiquitin-conjugating enzyme E2 K
- Polyubiquitin-B
- Ubiquitin-conjugating enzyme E2 G1
- Ubiquitin-conjugating enzyme E2 R2
- Ubiquitin-conjugating enzyme E2 A
- Ubiquitin-conjugating enzyme E2 R1
Sequence:
MERSEPLAVLSCEEASCSSWGACGASKNLPTMTTESLEIDDGLYSRQRYVLGDTAMQKMAKSCVFLSGMGGLGVEIAKNLVLAGIKALTIHDTKKCQAWDLGTNFFLCEDDVVNERNRAEAVLHRIAELNPYVQVSSSSAPLDETTDLSFLEKYQCVVLTEIKLTLQKKINNFCHSHCPPIKFISADVHGIWSRLFCDFGDEFEVSDTTGEEPKEIFISNITQANPGIVTCLESHPHKLETGQFLTFREIHGMTGLNGSVQQITVISPFSFSIGDTTKLDPYLHGGIAVQVKTPKTFCFEPLESQIKHPRCLIADFSKPEAPLEIHLAMLALDQFQENYNRKPNIRCQQDSDELLKLTVSINETLEEKPEVNADIVHWLSWTAQGFLPPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADTVESLGNPGHEEFLPRGDRYDAIRACIGNTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTGREKGMVTVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAAEATLKINPQLKIDAHLNKVCPATESIYSDEFYTKQDIIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEIIVPQLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQAYPSAEDVLQKIQNGQSLEGCFQVIKLLSRRPRIWSQCVELARLKFEKYFNHKALQLLHCFPLETRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQSAAKLYATVYCIPFSEKDLSVNSLMDILSEVKIEEFKPSNKVVQTDETARKPDHVPVSSEDERNAVFQLEEALSSNKATKSDLQMTVLSFEKDDDRNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATSTAAVSGLVALEMIKVAGGYPFDAYKNCFLNLAIPIIVFTETSEVRKTEIRNGISFTIWDRWTVHGKEDFTLSDFINAVKENYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPSTEKKYVDLTVSFAPDADGDEDLPGPPVRYYFSHDTNE
Protein: Chromatin modification-related protein YNG2 (ESA1-associated factor 4) (ING1 homolog 2) (P38806)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:10805724, ECO:0000269|PubMed:11544250, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Actin-related protein 4
- Enhancer of polycomb-like protein 1
- Chromatin modification-related protein EAF1
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
- Chromatin modification-related protein EAF3
- SWR1-complex protein 4
- Histone acetyltransferase ESA1
- Chromatin modification-related protein EAF6
- Protein AF-9 homolog
- Chromatin modification-related protein EAF5
Sequence:
MDPSLVLEQTIQDVSNLPSEFRYLLEEIGSNDLKLIEEKKKYEQKESQIHKFIRQQGSIPKHPQEDGLDKEIKESLLKCQSLQREKCVLANTALFLIARHLNKLEKNIALLEEDGVLAPVEEDGDMDSAAEASRESSVVSNSSVKKRRAASSSGSVPPTLKKKKTSRTSKLQNEIDVSSREKSVTPVSPSIEKKIARTKEFKNSRNGKGQNGSPENEEEDKTLYCFCQRVSFGEMVACDGPNCKYEWFHYDCVNLKEPPKGTWYCPECKIEMEKNKLKRKRN
Protein: SKA complex subunit 1 (Spindle and kinetochore-associated protein 1) (Q9XWS0)
Organism: Caenorhabditis elegans
Function: Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (By similarity). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. In the complex, it mediates the interaction with microtubules.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23085020}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:23085020}.
Interaction partners:
- Spindle and Kinetochore-Associated protein homolog
- Kinetochore protein ndc-80
- Protein zwilch homolog
- Reverse transcriptase domain-containing protein
- Probable deoxycytidylate deaminase
- Kinetochore protein Nuf2 homolog
- Mitotic checkpoint serine/threonine-protein kinase bub-1
- Maternal embryonic leucine zipper kinase
- Kinesin-like protein
- Outer kinetochore KNL1 complex subunit knl-1
Sequence:
MESFIDRITEETDENFRICRENIPNFETTISPLLNTMKNIKLLLDDAAFDQQKLENNCEETCMNCTKSQLNDFLGIKVEASTIVDVKSQLVPQSKESSALVETNEPNEQGLSSKPKENDIRIVPQITDEEFKTIPKYQLGRLTLEMMNEIVSKMDDFLMKKSKILGKTNKQLTRSDREVLDNWRELEMKARKRLPTTLFFIETDIRPMLQDRLRPSFAKAIPCLRHIRRIREERCGPLTFYYP
Protein: Cadherin-related neural recepter 5 (O88192)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
FSSKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSLECSIHLEVIVDRPLQVFHVEVEVRDINDNPPVFPETNKNIVIAESRPPETRFPLDGASDADIGVNSALTYRLDPSDYFALDTQNNRERTSSLSLVLKKSLDREEIQEYSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFDRFVYKVKVLEDALNGTLVINLNATDPDEGINGDIIYSFRRPVSPAVVHAFNIDSNSGEVRTKGLLDFEEIKLYEIPVEAVDKGNIPMTGHCTLLVELLDVNDNAPEVTITSLSLPVREDAQPSTVIALVSVSDRDSGDNGQVTCSLTPHLPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDRGSPSLWSTASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPSLGSNVTLQVFVLDENDNAPTLLPHRAVGAVGTVSELVPRSVGSGHVVAKVRAVDADSGYNAWLSYELQLAAGGMRSPFRVGLYTGEISTTRSLDEADAPRQRLLVLVKDHGEPALTATATVLVSLVENGQAPKISSLASESTASSEASLVTVNVYLIIAICAVSSLLVITLLLYTALRCSARSTDGACAPGKPMLVCSSAVGSWSYSQQRRQRVCSGEGPPKTDLMAFSPSLPPVLGSAEDTCQRERQVEHLKEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Protein: Uncharacterized transporter C757.13 (O74923)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- U4/U6.U5 small nuclear ribonucleoprotein component snu23
- UPF0494 membrane protein C212.04c
- WW domain-containing protein C11B10.08
- Uncharacterized transcriptional regulatory protein C11D3.11c
- Uncharacterized cox1 intron-2 37.2 kDa protein
Sequence:
MSSITSRVSSRSSHELTEKKSGVTNDFKNSFEVGEVKRLPDAEGTADAVAQELLADDDFTYTAKEARRVLWKIDLVMMPVMCITYMIQYLDKTALSYAALYGMKTDTHIDGHTYSSMTTLFYAGYLVAQYPAAILMQKCRLSYFIFCNVFLWSAMVCLMAACRNGPSLLGLRFLAGIFEASITPAFINITAMWYRREEQPMRTLCWYAFNGIAQIIGSILSYGLGHIHGKVASWRYVFIVIGLMSLGWGVVFVFIPSNPSKARFLSSREKRIALERVRDNRTGLENKQFKWKHAYEAFLDPQVIMITLFTGVCMITNGIGVFSTLIIKGLGYNELHSAVLNMPLGAIEVAAMFISGVLCKVFKNGRLLIGVFMNCLTLAGCLMIWKIPDSNPYGRLVGVWFTMWVPASSALLLSLISSNVAGYTKKTVTSATVFVFYSVGNIVSPQLFKSGQTPEYIEGIQAMIVSLCIIIAIAFVLTGYYIYENKRRDRLLAEDPSLGESIKNEEFMDLTDRQQPKFRYRW
Protein: Probable plasma membrane ATPase (PAT2) (EC 7.1.2.1) (P-type H(+)-ATPase) (Proton pump) (P54679)
Organism: Dictyostelium discoideum (Social amoeba)
Function: P-type plasma membrane H+-ATPase (proton pump). The proton gradient it generates drives the active transport of nutrients by H(+) symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Subcellular location: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:9421912}.
Interaction partners:
- Inorganic pyrophosphatase
- Vacuolar proton translocating ATPase 100 kDa subunit
Sequence:
MDNNQIPKNSPESSAINSAESSPKSNVSSDVLHENHHKEQQQLQQQLQQEQQQQQLPTTPQSEPTQRVNNNEEGIEMDRIAENSNINVPSDVGESSLKTISGYPSSKNTEAGSSSSGKKEEDYNYRSTWVPKLHQELFENPEVLESRRTKQRASNYRKTLEREKEGIKPLDNILEELKANANGLTKAEAQKRLEEVGPNAIPDVKRYPILEFLYFMWNPLSWTMEVAAIVSIALLDWVDFILICALLLLNATIGFIEENTAGNAVEALKNSLVSQIRCMRDGEWVMLPSPDLVPGDVVMLKIGAIIPADCRVIEAEQVKIDQSSLTGESLPVTKKIGDEVYSGSAMKQGEAKCVVTATGVNTFFGRAANLVQETEGHGHLQVILRNIGLFCISFIAIWVLVELLVDFLGYDGYCHGVGGGRCLPLNNALVLLVGGIPIAMPTVLSVTMAIGATQLSKKKAIVSRLASIEELAAMDILCSDKTGTLTLNILTVDEPLPVGDTPKEDIVFHAFLACSEGEDQDAIDKAISNYCRDTYPNVDYSGNEIVKHYPFNPEDKKAMGLVNANGKQFKTAKGAPQIILREADNYKQVGEAVEKEIENLADRGYRALGVSVSYDAPDFKVWHFEGLIPLFDPPRHDTEDTIKRALEMGVSVKMITGDQLAIAKETARRLGMGGNLFTIPYLENNDLGISEGEVIEMADGFAEMWPEHKYKVVDQLQKRKHVVGMTGDGVNDAPALKKAQIGIAVAGATDAARSVSDIVLTSSGLSVIIDAIISSRKIFQRMRNYVIYSVAATVRICTTFGILTVAWNFKFPTIATVIIAILNDGTMLTISKDRVRARNEPDQWNLFEVFTMALCYGFYLVGSTIVFFAIIHDGTWFHDAINLRILTDNELRGLIYLQVSISGLATIFVSRSQGFSYFERPGNLVIFAFVMSQIVATFIGVYGFRGYPHDSFSDNPDYPVHGTNFQGCGWGWAVCAWIWCFLWYIPMDFIKLGVTYILRGKIEPINKDALRKIYGWFGKEIPKEATQVSHKVAEQQAKRDALHAQETHHKSVVTDNKV
Protein: Post-GPI attachment to proteins factor 6 (EC 3.1.1.4) (GPI processing phospholipase A2) (GPI-PLA2) (Protein M83) (Transmembrane protein 6) (Transmembrane protein 8) (Transmembrane protein 8A) (Q9HCN3)
Organism: Homo sapiens (Human)
Function: Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane. In contrast to myomaker (TMEM8C), has no fusogenic activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27881714}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:21752829}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGRAGTGTGGEAVAAVVAGPLLLLLLARPPPASAGYSGKSEVGLVSEHFSQAPQRLSFYSWYGSARLFRFRVPPDAVLLRWLLQVSRESGAACTDAEITVHFRSGAPPVINPLGTSFPDDTAVQPSFQVGVPLSTTPRSNASVNVSHPAPGDWFVAAHLPPSSQKIELKGLAPTCAYVFQPELLVTRVVEISIMEPDVPLPQTLLSHPSYLKVFVPDYTRELLLELRDCVSNGSLGCPVRLTVGPVTLPSNFQKVLTCTGAPWPCRLLLPSPPWDRWLQVTAESLVGPLGTVAFSAVAALTACRPRSVTIQPLLQSSQNQSFNASSGLLSPSPDHQDLGRSGRVDRSPFCLTNYPVTREDMDVVSVHFQPLDRVSVRVCSDTPSVMRLRLNTGMDSGGSLTISLRANKTEMRNETVVVACVNAASPFLGFNTSLNCTTAFFQGYPLSLSAWSRRANLIIPYPETDNWYLSLQLMCPENAEDCEQAVVHVETTLYLVPCLNDCGPYGQCLLLRRHSYLYASCSCKAGWRGWSCTDNSTAQTVAQQRAATLLLTLSNLMFLAPIAVSVRRFFLVEASVYAYTMFFSTFYHACDQPGEAVLCILSYDTLQYCDFLGSGAAIWVTILCMARLKTVLKYVLFLLGTLVIAMSLQLDRRGMWNMLGPCLFAFVIMASMWAYRCGHRRQCYPTSWQRWAFYLLPGVSMASVGIAIYTSMMTSDNYYYTHSIWHILLAGSAALLLPPPDQPAEPWACSQKFPCHYQICKNDREELYAVT
Protein: Chorismate mutase 2 (PhCM2) (EC 5.4.99.5) (D2CSU5)
Organism: Petunia hybrida (Petunia)
Function: Mediates the conversion of chorismate to prephenate.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:B4FUP5}.
Interaction partners:
Sequence:
MACGDYDDKLSLDLIRDSLIRQEDTIIFNLIERIKFPINSTLYKKPSSWFPDFTGSLFQYLFQETEALQSKVGRYLSPEENPFFPDNLPASIVPPSKCPPVLHPVAESININEKILDVYLNQLLPLFCTEADEGNYATTAACDIQLLQAISRRIHYGKFVAEVKFRDCSDEYTPLILAQQDRDALMKLLTFEVVEEMVKKRVAKKAMIFGQEVTLVDNAKEVKCKVDPLLVSRLYDEWIMPLTKHVQVEYLLRRLDQNKLTSI
Protein: Homeobox protein GBX-2 (Gastrulation and brain-specific homeobox protein 2) (P52951)
Organism: Homo sapiens (Human)
Function: May act as a transcription factor for cell pluripotency and differentiation in the embryo.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Proto-oncogene Wnt-1
- Fibroblast growth factor 8
- Paired box protein Pax-2
- Homeobox protein OTX2
- Sonic hedgehog protein
Sequence:
MSAAFPPSLMMMQRPLGSSTAFSIDSLIGSPPQPSPGHFVYTGYPMFMPYRPVVLPPPPPPPPALPQAALQPALPPAHPHHQIPSLPTGFCSSLAQGMALTSTLMATLPGGFSASPQHQEAAAARKFAPQPLPGGGNFDKAEALQADAEDGKGFLAKEGSLLAFSAAETVQASLVGAVRGQGKDESKVEDDPKGKEESFSLESDVDYSSDDNLTGQAAHKEEDPGHALEETPPSSGAAGSTTSTGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAGNANSKTGEPSRNPKIVVPIPVHVSRFAIRSQHQQLEQARP
Protein: Anion exchange protein 4 (AE 4) (Anion exchanger 4) (Solute carrier family 4 member 9) (Q8K4V2)
Organism: Rattus norvegicus (Rat)
Function: Probable apical anion exchanger of the alpha-intercalated cells of kidney. May participate in HCO3(-) absorption.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:12225984}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the basolateral membrane of both alpha-intercalated cells and beta-intercalated cells in the cortical collecting duct (CCD) kidney cells (PubMed:12225984). Localized in the basolateral membrane of the submandibular gland (SMG) duct (By similarity). {ECO:0000250|UniProtKB:A0A494BA31, ECO:0000269|PubMed:12225984}.
Interaction partners:
- Carbonic anhydrase 2
Sequence:
MKLPGQEDFEGSDAHENVCSEQLDGDLGPGSGLDGPSDIDNGKAQGCKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDIGAGRWSAPHVPTLALPSLQKLRGLLAEGIVLLDCPARSLLELVEQVVRVESLSPELRGQLQALLLQRPQHHIQTTGIRPCRRSNAFRKASRDEDTLLKHQNPLRQKLPPGAEAAAVLAGELGFLEQPLAAFVRLQNPVVLEPLTEVVLPSRFFCLLLGPSTLGRSYHETGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLQEVTALPPGRWDRTARIPPPKCLPSQHKRFPSKLQEVTSLSRQSAALAENKHHHGPHTPIPELQRTGRLFGGLVQDVRRKACWYPSDFLDALHPQCFSAVLYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGATFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLIRAYPIQRPGSPAYSCFCQYPGTGGNASEFDSTMFKDTEDVLNVHPGLVNASFLPPSECIRQGGYPRGPSCHTVPDIAFFSLLLFFTSFLCAIALKHVKNSRLFPSVVRKVFSDFSSVLAILLGCGLDAFLGLATPKLLVPTEFKPTLPGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHMDSLRRESKACVPGEDPNFLGIREQRLTGLVVFILTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSMQFMKRVQLLLMPRKHQPDVLLLRHVPLIRVHLFTAIQLACLGLLWVIKSTPAAIVFPLMLLGLVAVRKALEWIFSPQELLWLDELMPEEEKTIPENRPEPEHLFSGNDSENSELMYQPKAPEINISVN
Protein: Calcium-dependent protein kinase 9 (OsCDPK9) (OsCPK9) (EC 2.7.11.1) (Q6AVI8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger (By similarity). Functions in signal transduction pathways that positively regulate responses to drought, osmotic, and dehydration stress. Regulates expression of stress-associated genes in response to drought. Involved in tolerance to drought stress by increasing proline and soluble sugars, and improving stomatal closure. Required for pollen maturation and spikelet fertility.
Subcellular location: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Os09g0438000 protein.
- Respiratory burst oxidase homolog protein B
- Os12g0541300 protein
- Os11g0537400 protein
- Os08g0453700 protein
- Os01g0734333 protein
- Os01g0734200 protein
- Os01g0734466 protein
- Os05g0528000 protein.
- Os01g0835500 protein.
Sequence:
MGNTCCVAPATTDEVGAPPRDHHHAAKKSPAPSATTTTATRQRHGQEPKPKPKPRARAKPNPYDWAPPRVLPARGGAAASAVRVLEGVVPHHPRLRVTDKYQLGRELGRGEFGVTHLATDRATRERLACKSIPKRRLRTAVDVADVRREVAIMASLPDHPALVRLRAAYEDADAVHLVMELCDGGELFDRIVARGRYTERAAAAAARTVAEVVRACHAHGVMHRDLKPENFLYAGKAEDAQLKAIDFGLSVFFRPGERFREIVGSPYYMAPEVLRRDYGPEVDIWSAGVILYILLCGVPPFWAETEQGVARAILRGAADFDREPWPRISRAAKSLVRQMLDVDPRRRPTAQQVLDHPWLHHAARAPNVPLGDVVRARLKQFSLMNRLKKKAMRVIAEHLSVEEVEVIKDMFALMDTDNNGRVTLQELKDGLTKVGSKLAEPEMELLMEAADVDGNGYLDYGEFVAVTIHLQRLSNDNHLRTAFLFFDKDGSGYIDRAELADALADDSGHADDAVLDHILREVDTDKDGRISYEEFVAMMKSGTDWRKASRQYSRERFKTLSNSLIKDGSITMAR
Protein: Nicastrin (F4J819)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAMGLIRLLSIAFTLVLLSILPLHLSLADEITSIESVPDLQKLMYVAVDGFPCVRLLNLSGEIGCSNPGINKVVAPIIKLKDVKDLVQPHTILVTADEMEDFFTRVSTDLSFASKIGGVLVESGSNFQQKLKGFSPDKRFPQAQFSPYENVEYKWNSAASSIMWRNYNFPVYLLSESGISAVHEILSKKKMKHGTYTSDVAEFNMVMETTKAGTHNSEACLQEGTCLPLGGYSVWSSLPPISVSSSNNRKPVVLTVASMDTASFFRDKSFGADSPISGLVALLGAVDALSRVDGISNLKKQLVFLVLTGETWGYLGSRRFLHELDLHSDAVAGLSNTSIETVLEIGSVGKGLSGGINTFFAHKTRVSSVTNMTLDALKIAQDSLASKNIKILSADTANPGIPPSSLMAFMRKNPQTSAVVLEDFDTNFVNKFYHSHLDDLCKKSHSLSFSSFRSKPHFALLIPFWCCIAANINSSSVVAAASVVARTLYILASDNKDTSNSALGSIHVNASFVEELLTCLLACEPGLSCNLVKDYISPTNTCPGNYAGVILGEPSSKPYLGYVGDVSRFLWNFLADKTSVQKGNTTSVCSKGVCSKTDEVCIKAESNKEGTCVVSTTRYVPAYSTRLKYNDGAWTILPQNSSDSMGMVDPVWTESNWDTLRVHVYTVQHSAYDNAVLVAGITVTTLAYIGILAAKSIITKALKQD
Protein: Anaerobic sulfatase-maturating enzyme homolog YdeM (AnSME homolog) (P76134)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized sulfatase YdeN
- Uncharacterized protein YidF
- UPF0718 protein YraQ
- Uncharacterized sulfatase YidJ
- Putative sulfatase AslA
Sequence:
MHVTAKPSSFQCNLKCDYCFYLEKESQFTHEKWMDDSTLKEFIKQYIAASGNQVYFTWQGGEPTLAGLDFFRKVIHYQQRYAGQKRIFNALQTNGILLNNEWCAFLKEHEFLVGISIDGPQELHDRYRRSNSGNGTFAKVIAAIERLKSYQVEFNTLTVINNVNVHYPLEVYHFLKSIGSKHMQFIELLETGTPNIDFSGHSENTFRIIDFSVPPTAYGKFMSTIFMQWVKNDVGEIFIRQFESFVSRFLGNGHTSCIFQESCKDNLVVESNGDIYECDHFVYPQYKIGNINKSELKTMNSVQLTAQKKRIPAKCQQCAYKPICNGGCPKHRITKVNNETVSYFCEGYKILFSTMVPYMNAMVELAKNRVPLYHIMDVAKQMENN
Protein: Exostosin-like 2 (EC 2.4.1.223) (Alpha-1,4-N-acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Q9ES89)
Organism: Mus musculus (Mouse)
Function: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Exostosin-like 3
- Beta-1,3-galactosyltransferase 6
- Glycosaminoglycan xylosylkinase
- Xylosyltransferase 1
- Xylosyltransferase 2
Sequence:
MMRGCHICKLPGRVMGIRVLRFSLVVILVLLLVAGALTNLLPNIKEDKMLTLRREIKSPSKSALDSFTLIMQTYNRTDLLLRLLNHYQAVPSLHKVIVVWNNVGEKGPEELWNSLGPHPIPVIFKPQTANKMRNRLQVFPEVETNAVLMVDDDTLISAQDLVFAFSIWQQFPDQIIGFVPRKHVSTSSGIYSYGGFELQTPGPGNGDQYSMVLIGASFFNSKYLELFQKQPAAVHALIDETQNCDDIAMNFLVTRHTGKPSGIFVKPINMVNLEKETNGYSGMWHRAEHFLQRSYCINKLVNIYDGMPLKYSNIMISQFGFPYANHKSKM
Protein: Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) (Sid 329) (Q9R0Q6)
Organism: Mus musculus (Mouse)
Function: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q92747}. Nucleus {ECO:0000250|UniProtKB:Q8AVT9}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin-related protein 2
- Actin-related protein 3
- Actin nucleation-promoting factor WASL
- Actin-related protein 2/3 complex subunit 1B
- Actin nucleation-promoting factor WAS
Sequence:
MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWTKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGIWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGNRLAWVSHDSTVSVADASKSVQVSTLRTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDVPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM
Protein: Brevinin-1DYb (Brevinin-1CDYb) (P0C5W7)
Organism: Rana dybowskii (Dybovsky's frog) (Korean brown frog)
Function: Antimicrobial peptide. Has low activity against the Gram-positive bacterium S.aureus and the Gram-negative bacterium E.coli (MIC<15 uM). Has a strong hemolytic activity.
Subcellular location: Secreted {ECO:0000269|PubMed:17688900}.
Interaction partners:
Sequence:
MFTLKKSLLLLFFLGTISLSLCEEERNAEEERRDYPEERDVEVEKRFLSLALAALPKLFCLIFKKC
Protein: RNA polymerase sigma factor FliA (RNA polymerase sigma factor for flagellar operon) (Sigma F) (Sigma-28) (A0A0F6B2T8)
Organism: Salmonella typhimurium (strain 14028s / SGSC 2262)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00962}.
Interaction partners:
Sequence:
MNSLYTAEGVMDKHSLWQRYVPLVRHEALRLQVRLPASVELDDLLQAGGIGLLNAVDRYDALQGTAFTTYAVQRIRGAMLDELRSRDWVPRSVRRNAREVAQAMGQLEQELGRNATETEVAERLGIPVAEYRQMLLDTNNSQLFSYDEWREEHGDSIELVTEEHQQENPLHQLLEGDLRQRVMDAIESLPEREQLVLTLYYQEELNLKEIGAVLEVGESRVSQLHSQAIKRLRTKLGKL
Protein: Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (PPAR-interacting protein 4) (PIP4) (dUTP pyrophosphatase) (P70583)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (By similarity). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. Essential for embryonic development (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8910358}. Nucleus {ECO:0000269|PubMed:8910358}. Note=Binding to PPAR induces translocation to the nucleus. {ECO:0000269|PubMed:8910358}.
Interaction partners:
- Thymidylate synthase
- Thymidine kinase, cytosolic
- Inosine triphosphate pyrophosphatase
- Deoxycytidylate deaminase
- dTMP kinase
- Nucleoside diphosphate kinase homolog 7
- Adenylate kinase 9
- Nucleoside diphosphate kinase A
- Nucleoside diphosphate kinase 6
- Nucleoside diphosphate kinase B
Sequence:
MPLLCALLRSRLQPSLLRSLTLTSAQSLSCGGSRGVRTWSARTGPGACADPAVSVSKRARAEDDASLRFVRLSEHATAPTRGSARAAGYDLYSAYDYTIPSMEKALVKTDIQIAVPSGCYGRVAPRSGLAVKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERILYPDLEEVQTLDNTERGSGGFGSTGKN