wanglab/gogpt-training-data huggingface dataset:
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0B4KF69)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Serine-arginine protein 55
- LD40489p
- Cell division cycle 5, isoform A
- Zinc finger matrin-type protein CG9776
- Arginine and glutamate-rich protein 1
Sequence:
MNKADVNRRVLAIQAKKKRHKNRKRGKQNGTNPQEQSNSSQNQNPKPSSNPIPEPNRSSENLQAPDNANNSHLNAPSSAAFSKATATATASTSSGGSAGTPDQYQPPKKTQAKAKPNTQKEHQQQPPRSSSNESYESETFSDNEDQELMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYPSLVSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAGQPSRKQREERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWLRXDTMQPGCWLRATQPATADGDGGALAGTGTGKGTRARATALKGGSPAVPADGEVGRGYIESSASVATLASISSIASTSAAAMAALKARPYLVAPFVTTASAPPTPHPHASISTSTARTAPATPTRRRIAPEDDLNLVEDLDVALAQIEDTQTHTKNKSQRFFWRKALRRVFQRRK
Protein: Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] (Q28685)
Organism: Oryctolagus cuniculus (Rabbit)
Function: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
Subcellular location: [Alpha-dystroglycan]: Secreted, extracellular space {ECO:0000250}.; SUBCELLULAR LOCATION: [Beta-dystroglycan]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Cell membrane, sarcolemma {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}. Note=The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3 (By similarity). Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity). Colocalizes with ERM proteins in Schwann-cell microvilli (By similarity). In peripheral nerves, localizes to the Schwann cell membrane. {ECO:0000250}.
Interaction partners:
- Dystrophin
- Neurexin-1
- Laminin subunit alpha-2
- Alpha-sarcoglycan
- Utrophin
- Sarcospan
- Sarcoglycan delta
- Gamma-sarcoglycan
- Neuroglobin
- Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Sequence:
MRMSVGLSLLLPLWGRTFLLLLCVAVAQSHWPSEPSEAVRDWENQLEASMHSVLSDLHEALPTVVGIPDGTAVVGRSFRVTIPTDLIGSSGEVIKVSTAGKEVLPSWLHWDPQSHTLEGLPLDTDKGVHYISVSAAQLDANGSHIPQTSSVFSIEVYPEDHSEPQSVRAASPDLGEAAASACAAEEPVTVLTVILDADLTKMTPKQRIDLLHRMQSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCSLNQNSVPDIRGVEAPAREGTMSAQLGYPVVGWHIANKKPPLPKRIRRQIHATPTPVTAIGPPTTAIQEPPSRIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTTRTRGAIIQTPTLGPIQPTRVSDAGTVVSGQIRATVTIPGYVEPTAVATPPTTTTKKPRVSTPKPATPSTDSSATTTRRPTKKPRTPRPVPRVTTKAPITRLETASPPTRIRTTTSGVPRGGEPNQRPELKNHIDRVDAWVGTYFEVKIPSDTFYDKEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGGLSAVDAFEIHVHKRPQGDKAPARFKAKFVGDPAPVVNDIHKKIALVKKLAFAFGDRNCSTVTLQNITRGSIVVEWTNNTLPLEPCPKEQITGLSRRIAEDNGQPRPAFTNALEPDFKATSIAITGSGSCRHLQFIPVAPPGIPSSVTPPTEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGKLTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPSQSVPETTPLNQDTVGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP
Protein: Lysophosphatidic acid receptor 4 (LPA receptor 4) (LPA-4) (G-protein coupled receptor 23) (P2Y purinoceptor 9) (P2Y9) (P2Y5-like receptor) (Purinergic receptor 9) (Q99677)
Organism: Homo sapiens (Human)
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Lysophosphatidic acid receptor 1
- Lysophosphatidic acid receptor 2
- Lysophosphatidic acid receptor 3
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein G
- Lysophosphatidic acid receptor 5
- Angiotensinogen
- Lysophosphatidic acid receptor 6
Sequence:
MGDRRFIDFQFQDSNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSVSLFVFCFRMKMRSETAIFITNLAVSDLLFVCTLPFKIFYNFNRHWPFGDTLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPATLSQIGTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQAITNCFLERFAKIMYPITLCLATLNCCFDPFIYYFTLESFQKSFYINAHIRMESLFKTETPLTTKPSLPAIQEEVSDQTTNNGGELMLESTF
Protein: T. brucei spp.-specific protein (Q582N9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGTIEGTTVDFDPNPLQCPTKTILVGNEDATAGVLPRTSRHIDFTDDGKLFEGHFTLQASSLKSIIQVLADQQAEQRVIINDLQDQVNNLRQQTSKMRKSVPTLQLPASVGGSAKSFSKEYESLEQRVKSLEGFRSLWGARTEDVDGLISIYGDPVVTPDEYTTYIMNLQPFRVVRSEARHFVTSQAEQQKQAVRTVGGERNERTRGARSARLADPGDAADDGSRTPREGGSRAPRDGSQSGRDDSRGSRRFRKRQSADDDSKPAREDDSGAPRDDSQSGRDGSRGPRSARNRQAHDAERKSSRDDDSRTVRDDNNFANDDNRSGRDETRGRRRVREPQSNDDGTRSPIEESHANRDDTRPGRDDSRGSRRQRNRQSHEDDLKSFHEEDARTHRGGPRGARDRVTYGEHLDSRDGLRQDNIGDGDTISDLSKRLQLLEQRVRSVHGGHKNNAQGSASEQLSPTSDATGAKDLQAREDIEELSRFVAKRFKELERSIAKVQGGDLNVTAPKAGMGARKSETPPKRRERSPTVMSKGQTGAGGSGPGPSGAVESDLLQKAGKPREIAPSYTPVVDEVARDDAAAALEQVELLEKYVVRKLKELTPSLSKGVSDTHISSPPIGSTSTQPPERPSGESHVPRGADRSASEKVAVDQAAREDTSRLFELVHDLEDDWGKRWASLEERLRIIGRAAVNKGSVNAAAPGTIDRRAREDASISLMRVQQLEREISSFRRLLMKRNGAPMEVGLFEGRMQSGGASKLVVDARDQKEPNDNGCAGLGAVLEGADSQSRVLALEKEVESRMEEVNRALATLRTAQVGQDFPDLSFLGDDTGTRKSTAPSQIVISTREMDLAAAGNFRRPTPDTKTYAAMLVMSSYDPAQPFHGSYSNYDQGNPIVLRPPQMETFATPLVRREPQDNLTPRTRGEAGVAVGTPQHEKSPVNKAATQSGEAGLSPSGTGSCPIRMSGPAPHPPDGSAICPVAPHKQSVMQHLGDMRSVSSRVRGRESTRMGSQNILGRETVLGTKGRAGLGLVAESSALGHRTPCVVPNCAWCAVQNVKATVKTAR
Protein: ADAM metallopeptidase domain 28 (A0A8I6A4L8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MQQWRLLVVWFLLSPVPASAIKELPKAKNYEVVYPIRLHLLHKRETKEPEPKETFETELRYKMTVNGKVVELYLKKNNKLLAPGYLETYYNSSGNKVTTSPQIMDSCYYQGHIINEKDSAASISMCQGLRGYFSQADERYFIEPLSSEILDEQAHALFKDDPKEDQENSNCGVDDALWLQGLHQDVVLPATRLIKLNDGMVQEPKKYIEYYVVLDNGEFKKYNKNLDEIRKRVHEMANYVNMLYNKLDAHVALVGMEIWTDEDKIKITPDANTTLENFSKWRGNDLLKRKHHDVAQLISSTDFSGSTVGLAFMSSMCSPYHSVGIVQDHSNYHLRVAGTMAHEMGHNLGMIHDYLSCKCPSEVCVMEQSLRFHMPTDFSSCSRDNYRRFLEEKLSHCLFNSPLPSDIISTPVCGNQLLEMNEDCDCGTPKECTNKCCDAETCKIKAGFQCALGECCEKCQLKKPGVVCRAAKDECDLPEMCDGKSSHCPVDRFRVNGFPCQNGHGYCLKGNCPTLQQQCMDMWGPETKVANKSCYKQNEGGSKYGYCHVENGTHMPCKAKDAMCGKLFCEGGSGDLPWKGLTIAFLTCKLFDPEDINQGVDMVANGTKCGNNKVCINAECVDMEKTYKSANCSSKCKGHAVCDHELQCQCKEGWAPPDCEDSATVFRVSIMVGVLFPLAAIFVVIAIVIHHQSARRKQRRVQRLPPIKDAKLHKQKCRPQKVKDIQPQELITKPNFPPPPIPVS
Protein: Thymosin beta (Q45QT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR001828}.
Interaction partners:
- Actin alpha 1, skeletal muscle b.
- Actin, cytoplasmic 1
- Actin, cytoplasmic 2
- Thymosin beta
- Thymosin beta
- Wilms tumor protein homolog
- T-box transcription factor 18.
- Profilin
Sequence:
MSDKPNLEEVTSFDKTKLKKTETQEKNPLPSKETIEQEKQAGSS
Protein: Peroxisomal (S)-2-hydroxy-acid oxidase GLO4 (EC 1.1.3.15) (Glycolate oxidase 4) (GOX 4) (OsGLO4) (Short chain alpha-hydroxy acid oxidase GLO4) (Q8H3I4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Oxidase that catalyzes the oxidation of a broad range of 2-hydroxyacids to the corresponding 2-oxoacids, with a reduction of O2 to H2O2. May be involved in a general medium- and long-chain fatty acid catabolic pathway such as alpha-oxidation.
Subcellular location: Peroxisome {ECO:0000250}.
Interaction partners:
- alanine--glyoxylate transaminase
- Malate synthase
- Isocitrate lyase
- glycerate dehydrogenase
- Catalase isozyme C
- Os04g0107500 protein
- Os04g0106400 protein
- Alanine aminotransferase 2
- Catalase isozyme A
- Catalase isozyme B
Sequence:
MEDNLPVNVREYQELAKKALPKMAYDYINGGAEDEHTLRENIAAYTRIILRPRVLVDVSKIDMSTTLLGYTMRSPIIVAPTGGHKLAHPEGEKATARAAASCNAIMVLSFSSSCKIEDVASSCNAIRFYQLYVYKNRNVSATLVRRAESCGFKALLLTVDTPMLGRREADIRNKMVFPRSGNLEGLMTTDDHDTTNGSQLERFARATLDPSLSWKDIEWLKSITSMPIFLKGIVTAEDARRAVEAGVAGVIVSNHGARQLDYAPATIAALEEVVRAVAGAVPVLVDGGIRRGTDVFKALALGARAVMVGRPVFFGLAARGEAGARHVIEMLNGELEVAMALCGCRSVGEITRSHVMTEGDRIRSLL
Protein: GH10642p (Hebe, isoform B) (Hebe, isoform D) (Hebe, isoform E) (Hebe, isoform F) (Q7K568)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- IP04456p
- Uncharacterized protein, isoform A
- GEO12575p1
- Uncharacterized protein, isoform C
Sequence:
MAETINNKPSIQIRSGLPSPLPDKSPSPATKLLISHGKPNFTIAKSPKIDENGNGNPLSAQPSANNNYNAYKSANSSVANSQKFIVGTKFNGVFKPSNAAATWATNGSTNGNGTAESENEVAKVVLRRPKVADSPPPAEGEDENVPEFIRRQRLIQERLAKENVLDFESRRSGYFTHVMISPDSPNRTSFVETMASPAIVPALEIPAPVAEKVEEEEKVEVQPQVAAVTTSALITKPEPEDPVSNGHSEEPKNSDVGPEEVAKAIEQVNQAVAGEDEAEVEATPEPVPEPTPEPVAAERKAEAVVEEPTQAPAAVEAKVEVVEPAAPVQNGQKEEEKAVPATNGLKEEEAAPATNGHKEEADAITISHTNGQSSDGPSIPTPDPSGALGVNYEPKTVVSFSQELGSGENKYPDTVKVVSEVPAESNGELKELTKLKFDIQSDDQNEVQVTPVLRAE
Protein: Auxin-responsive protein IAA9 (Indoleacetic acid-induced protein 9) (Q38827)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin response factor 5
- Auxin response factor 7
- Auxin response factor 8
- Auxin response factor 6
- Protein AUXIN SIGNALING F-BOX 2
- Auxin transporter protein 1
- Auxin response factor 18
- Auxin response factor 4
- Auxin response factor 3
Sequence:
MSPEEELQSNVSVASSSPTSNCISRNTLGGLKEHNYLGLSDCSSVGSSTLSPLAEDDKATISLKATELTLGLPGSQSPARDTELNLLSPAKLDEKPFFPLLPSKDEICSSSQKNNASGNKRGFSDTMDQFAEAKSSVYTEKNWMFPEAAATQSVTKKDVPQNIPKGQSSTTNNSSSPPAAKAQIVGWPPVRSYRKNTLATTCKNSDEVDGRPGSGALFVKVSMDGAPYLRKVDLRSYTNYGELSSALEKMFTTFTLGQCGSNGAAGKDMLSETKLKDLLNGKDYVLTYEDKDGDWMLVGDVPWEMFIDVCKKLKIMKGCDAIGLAAAPRAMEKSKMRA
Protein: Uncharacterized protein YMR295C (Q03559)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Uncharacterized protein YGR017W
Sequence:
MMHFRKKSSISNTSDHDGANRASDVKISEDDKARLKMRTASVADPILDAVQEAQPFEQAADTFHDNMNRQSYFSNEEGHVLCDVFGQPITQADISNPTRARDERPLDTIRSFEYAVSGDPVWAQQLETPTYGFRVRPDFPVFGAAVTYDANGMPQQVGGASSQMYGEQAVYQPQQHVQTEEKQKKKKKGLFGRMKKK
Protein: Zinc transporter ZIP9 (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (ZIP-9) (Q8BFU1)
Organism: Mus musculus (Mouse)
Function: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (By similarity). Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9NUM3}. Cell membrane {ECO:0000250|UniProtKB:Q9NUM3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NUM3}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9NUM3}. Mitochondrion {ECO:0000250|UniProtKB:Q9NUM3}. Nucleus {ECO:0000250|UniProtKB:Q9NUM3}.
Interaction partners:
- Zinc transporter ZIP11
- Zinc transporter SLC39A7
- Zinc transporter 7
- Zinc transporter ZIP13
- Proton-coupled zinc antiporter SLC30A5
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter ZIP1
- Zinc transporter ZIP12
- Zinc transporter 6
- Zinc transporter ZIP10
Sequence:
MDDFLSISLLSVAMLVGCYVAGIIPLAVNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEEVLEGKHHQTSEMKQNGIASDKAAEISSVHEHEHSHDHTQLHAYIGVSLVLGFVFMLLVDQIGSSHVHSSDDPETARPSSSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPAMSMLTYLGLSKSSKEALSEVNATGVAMLFSAGTFLYVATVHVLPEVGGMGHSHKPDTTGGRGLSRLEVAALVLGCLIPLILSIGHQH
Protein: Pre-mRNA-splicing factor CEF1 (PRP nineteen-associated complex protein 85) (PRP19-associated complex protein 85) (Q03654)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing and cell cycle control. Required for the binding of the NTC complex (or PRP19-associated complex) components to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Its absence leads to an arrest of the cell cycle, possibly due to the inefficient splicing of TUB1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
- Pre-mRNA-splicing factor BUD31
- Splicing factor YJU2
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22
- Small nuclear ribonucleoprotein Sm D2
- Pre-mRNA-splicing factor RSE1
- Small nuclear ribonucleoprotein-associated protein B
- Small nuclear ribonucleoprotein E
- Pre-mRNA-splicing factor PRP9
- Pre-mRNA-splicing factor CWC26
Sequence:
MPPVPIYVKGGVWTNVEDQILKAAVQKYGTHQWSKVASLLQKKTARQSELRWNEYLNPKLNFTEFSKEEDAQLLDLARELPNQWRTIADMMARPAQVCVERYNRLLESEDSGGAALSTGVTDLKAGDINPNAETQMARPDNGDLEDEEKEMLAEARARLLNTQGKKATRKIRERMLEESKRIAELQKRRELKQAGINVAIKKPKKKYGTDIDYNEDIVYEQAPMPGIYDTSTEDRQIKKKFEQFERKVNRKGLDGNKDKPSKKNKDKKRKHDENEHVEKAALGESTTLTDEYKKPKLILSAPGTKQGKVTYKKKLESKRQKLIEAQATGTVLTPKELLPHDSGQEDNERSNIKSGKQLKSRIRKFLVQMFASLPSPKNDFEIVLSEDEKEEDAEIAEYEKEFENERAMNEEDNFIEPPSQNDAPRVSLVAVPLAYSTLPIPEFKNNPQSAIDNKYNLLVANAINKEPHMVPEDTVDFLKEVESRMQHITQGRTSMKIQFKTAMPPTEVLLESIQSKVESIEQLQRKLQHVQPLEQQNNEMCSTLCHHSLPALIEGQRKYYADYYAYRQEIRSLEGRRKRLQAMLNSSSSI
Protein: 5'-3' exoribonuclease 1 (H7C5E4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XTNEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDERLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIENFLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMKGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALFALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTANIMPSSSHLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHHKSTPISSSRRKSRKLAVNFGVSKPSE
Protein: UBX domain-containing protein 4 (Q9P7L2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
Sequence:
MATIYACRGFHRVPVKLSPSSTLQEVILSSYKQLGFSDWHNLELLHGDKKVDTSLLLRLSGIINGAKLIVKESATNQSGKSSSSISPQSKKIKVALQLPGAARIIDEASSETSIKQLLERHSLLTKVSHVLINGRNFKSEEFDNPLLLYGIREGSILIRLFPIKAQQSIVSEQAPVSQTFNGDVKEKKNADLMDIESENKKDDIVESFPKYPVDAHKLLEPLPTPIPSLPSTPSSYQNLPSQSLTGESLPTVSNQEKDEGVIEKVAVNNTPSVSSKSPFPKKKSFSSMLAQVKKEKAENNGSDGYDLQPTKSQLELYQSILRKRANQVSSTSLTKSSSPKPLPSSAIVKFDFGNGKSIVHEFSKDDNIETLRAFVASHLSPEESTSFQLTFSNYEALPTTGLIVEHIGRAVVRVHTISDPVYAQR
Protein: Antifreeze protein Maxi (5a-like AFP) (Type 1 hyperactive antifreeze protein) (AFP Hyp-1) (B1P0S1)
Organism: Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus)
Function: Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point by about 1.1 degrees at a concentration of 0.1 mg/ml, and by about 1.5 degrees at a concentration of 0.2 mg/ml. Binds to nascent ice crystals and prevents further growth.
Subcellular location: Secreted {ECO:0000269|PubMed:15141201, ECO:0000269|PubMed:15716269}.
Interaction partners:
Sequence:
MALSLFTVGQFIFLFWTISITEANIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP
Protein: RNA-binding protein 7 (RNA-binding motif protein 7) (Q9Y580)
Organism: Homo sapiens (Human)
Function: RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). Participates in several biological processes including DNA damage response (DDR) and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:25852104}. Nucleus {ECO:0000250|UniProtKB:Q9CQT2}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:21855801}.
Interaction partners:
- Exosome RNA helicase MTR4
- Zinc finger CCHC domain-containing protein 8
- Splicing factor 3B subunit 2
- Exosome complex component RRP40
- Exosome complex component RRP43
- Serrate RNA effector molecule homolog
- Exosome complex component 10
- Exosome complex component RRP42
- Nuclear nucleic acid-binding protein C1D
- Splicing factor 1
Sequence:
MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLYGRPIKIQFRSGSSHAPQDVSLSYPQHHVGNSSPTSTSPSRYERTMDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH
Protein: At1g69250 (F4N2.20) (Nuclear transport factor 2 (NTF2) family protein with RNA binding (RRM-RBD-RNP motifs) domain-containing protein) (Putative RNA-binding protein; 63745-61607) (Q9LDI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 24
- RNA-binding
- Cysteine-rich receptor-like protein kinase 18
- Nuclear transport factor 2 family protein
- Zinc finger protein CONSTANS-LIKE 13
- NTF2-like protein
Sequence:
MATEGVVPSAQDIAAEFVRQYYHVLGQLPHEARRLYVDASVVSRPDVTGTMMSFTSVEAINKHILSCDFENTKFEVLSVDSQNSLEDGIFIMVIGFMTGKDNQRRKFSQMFYLARQNTLVVLNDMLRYVDQEDSSTTETPCEPVTEIVRPADGLKKAEKTELKQKNVASVEKSVNAAVEKNAAPLDNGKMKQSEKAVITQKVTEPDAAPQPDGAKRSFADIVGSMAKNAAPFQVKSPVQAPVQKPKYVGQPRAAAAPQKPAYVSKSIKKNDQKVIEVPGTSIFVANLPLNAMPPQLFELFKDFGPIKENGIQVRSSRGNANPVCFGFISFETVASVQSVLQAAKNTPFMLADRKLRVKEKEVDYDGSKPSGKTKGGSNKTQNGSADSSKTENGSADDSKTNGSAEDGEKEFKQVKSRRNRKKSEAAH
Protein: Collagen alpha-1(XXV) chain (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)] (Q99MQ5)
Organism: Mus musculus (Mouse)
Function: Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=After proteolytic cleavage, CLAC is secreted. {ECO:0000250}.
Interaction partners:
- Collagen alpha-1
- Furin
Sequence:
MLVKKLAGKGGGRESGSEDPRPLGQRCAGTMPSCTALATLLSVVAVAFCFYLGVKTNDLQARIAALESAKGTPSFHPLSDTVDELKAMVQEKVERLLAQKSYEHMAKIRTAREAPLECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGPLGPPGQKGSIGAPGTPGMDGQKGEPGSPGAAGQSGLPGPKGEPGKEGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGTKGDRGEAGPPGRGERGDPGAPGPKGKQGESGARGPKGSKGDRGDKGDSGALGPRGPPGQKGDPGATEIIDYNGNLHEALQRITTLTVTGPPGPPGPQGLQGPKGEQGSPGIPGVDGEQGLKGSKGDMGDPGVPGEKGGLGLPGLPGANGVKGEKGDTGLPGPQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGASGLDGKPGSRGADGPIGPHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK
Protein: Deoxyribonuclease TATDN1 (EC 3.1.21.-) (Hepatocarcinoma high expression protein) (Q6P1N9)
Organism: Homo sapiens (Human)
Function: Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules (By similarity). Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MSRFKFIDIGINLTDPMFRGIYRGVQKHQDDLQDVIGRAVEIGVKKFMITGGNLQDSKDALHLAQTNGMFFSTVGCHPTRCGEFEKNNPDLYLKELLNLAENNKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMKRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFPGI
Protein: RE50040p (Q9VCC2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Protein BCCIP homolog
- NADH:ubiquinone oxidoreductase subunit V3
- Ergic53, isoform A
- Protein transport protein SEC23
Sequence:
MTKPTREHCSLALLALLVAPFVVLGEDMPREPDYMKREHSLVRPFQGVGVILPHWDFLGNTMVTSNYIRLTPDLQSKSGALWNYSPVMTRNWEVHVGFKVHGKGTELFGDGFAIWYTKERMQTGPVFGSKDHFSGLAIILDTYSNHNGPHNHQHPYLSAMVNNGSWSYDHDRDGTHTQLAGCEVRFRNVEYETLVSIRYENDILSVSTDLENRNEWKNCFVVANVELPTGYHFGMSATTGDLSDNHDIHSFKFYDLDLNVNHDEIIRRSNIIPNAKTFEPPREHKEDPKPGMSNAKIFFILLFVVVVAAAVAIFAISYFKDRNARKRFY