wanglab/gogpt-training-data huggingface dataset:
Protein: Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) (Q3KNJ2)
Organism: Mus musculus (Mouse)
Function: DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends. Interacts with POLL (DNA polymerase lambda); promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL (By similarity). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary. Associates with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (By similarity). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (By similarity). Binds DNA in a length-dependent manner (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9H9Q4}. Chromosome {ECO:0000250|UniProtKB:Q9H9Q4}. Note=Localizes to site of double-strand breaks; recruitment is dependent on XRCC5-XRCC6 (Ku) heterodimer. {ECO:0000250|UniProtKB:Q9H9Q4}.
Interaction partners:
- X-ray repair cross-complementing protein 6
- DNA repair protein XRCC4
- DNA-dependent protein kinase catalytic subunit
- DNA ligase 4
- X-ray repair cross-complementing protein 5
- Protein PAXX
- TP53-binding protein 1
- Protein artemis
- Serine-protein kinase ATM
- DNA repair protein XRCC1
Sequence:
MEELEQDLLLQPWAWLQLAENSLLAKVSITKHGYALLISDLQQVWHEQVDTSVVSQRAKELNKRLTAPPAALLCHLDEALRPLFKDSAHPSKATFSCDRGEEGLILRVQSELSGLPFSWHFHCIPASSSLVSQHLIHPLMGVSLALQSHVRELAALLRMKDLEIQAYQESGAVLSRSRLKTEPFEENSFLEQFMAEKLPEACAVGDGKPFAMSLQSLYVAVTKQQIQARQAHKDSGETQASSSTSPRGTDNQPEEPVSLSSTLSEPEYEPVAASGPMHRARLVKSKRKKPRGLFS
Protein: Ciliary microtubule associated protein 1A (Outer dense fiber of sperm tails protein 3) (Outer dense fiber protein 3) (Sperm tail protein SHIPPO 1) (Transcript induced in spermiogenesis protein 50) (Q96PU9)
Organism: Homo sapiens (Human)
Function: Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q920N1}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q920N1}. Note=Expressed in the cytoplasmic lobe of spermatids. {ECO:0000250|UniProtKB:Q920N1}.
Interaction partners:
- Outer dense fiber protein 4
Sequence:
MTEEVWMGTWRPHRPRGPIMALYSSPGPKYLIPPTTGFMKHTPTKLRAPAYSFRGAPMLLAENCSPGPRYNVNPKILRTGKDLGPAYSILGRYQTKTMLTPGPGDYFPEKSTKYVFDSAPSHSISARTKAFRVDSTPGPAAYMLPMVMGPNTVGKASQPSFSIKGRSKLGGFSDDLHKTPGPAAYRQTDVRVTKFKAPQYTMAARVEPPGDKTLKPGPGAHSPEKVTLTKPCAPVVTFGIKHSDYMTPLLVDVE
Protein: Uncharacterized FAD-binding protein C1783.01 (Q9US28)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Sulfite reductase subunit beta
Sequence:
MISHVLVKDTSCLKVRTSYKCFVKYFPKCSVQSSFHSYDELAFSRRLYNLPRTLLNSRYYSNHSHGLVHGSKSPPSSQFLVPSFLQFNGQLKALCNNSAFQALPIKLSDLQKHWPSLKPHPLPPKRVSLGIPSISNPPVDTVISDSPTSPHPPSFVQPHPPYGIFAAPILDVRVLTNPGAVKRTYNLCLDISKYPLLEGKDWKIGGSFGIMPPNSDAEVLHLAHLLKIPQHELYVTKVLRTNGGRWPTIWGEDKPRCLYTSLYHIFKWCSDFISKPPTKSLIRLLAEHTLNPVEKSVLLALSDFRQDESYCRICTQSCVTLPDILEAFPSCHPPVDHLISALPQLMPRWYSISNDPSLANKRLEMAFTVQEYHSPNGQSRTGICTGFLEDLALAFLKARHDGSLANKKFTVPMFRGVQQNPFAKEFHNDGPMCLIGAGVGIAPFRGFVQRRLANAACTGKVWIIQGCRDQKLDELYHGEWNTVPGHHKNPKCRAKKLVVESRNGRREYVQDAVRRHGDVIWDVLSHKNGRIYLCGSGNSFVSEIEKALMDVAMKYGKLSKEEAQKELKNWQKPMNCKLIKEVW
Protein: Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Q6P6V0)
Organism: Rattus norvegicus (Rat)
Function: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19343716}. Secreted {ECO:0000250|UniProtKB:P06744}.
Interaction partners:
- GDH/6PGL endoplasmic bifunctional protein
- Phosphoglucomutase-1
- Glucose-6-phosphate 1-dehydrogenase
- Mannose-6-phosphate isomerase
- ATP-dependent 6-phosphofructokinase, platelet type
- ATP-dependent 6-phosphofructokinase, liver type
- Transaldolase
- ATP-dependent 6-phosphofructokinase, muscle type
- Triosephosphate isomerase
- Transketolase
Sequence:
MAALTRNPEFQKLLEWHRANSANLKLRELFEADPERFNHFSLNLNTNHGHILLDYSKNLVNKEVLHMLVDLAKSRGVEAARDNMFSGLKINSTEDRAVLHVALRNRSNRSIMMDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKAITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLANLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTDKVKEFGIDPKNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWMDQHFMKTPLDKNAPVLLALLGIWYINFYGCETHAMLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDYQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRNGLHHKILLANFLAQTEALMKGKSPEEARKELQAAGKSPEELEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSSAVTSHDSSTNGLIGFIKLQRDTKID
Protein: GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) (Q6Y7W6)
Organism: Homo sapiens (Human)
Function: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay. Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA. May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors.
Interaction partners:
- Eukaryotic translation initiation factor 4E type 2
- Growth factor receptor-bound protein 10
- E3 ubiquitin-protein ligase ZNF598
- Probable ATP-dependent RNA helicase DDX6
- F-box only protein 7
- GRB10-interacting GYF protein 1
- Ubiquitin carboxyl-terminal hydrolase isozyme L1
- Leucine-rich repeat serine/threonine-protein kinase 2
- 85/88 kDa calcium-independent phospholipase A2
- Serine protease HTRA2, mitochondrial
Sequence:
MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY
Protein: Basal-body rod modification protein FlgD (P75936)
Organism: Escherichia coli (strain K12)
Function: Required for flagellar hook formation. May act as a scaffolding protein.
Interaction partners:
- Flagellar basal-body rod protein FlgF
- Flagella basal body P-ring formation protein FlgA
- Flagellar hook-associated protein 3
- Flagellar hook protein FlgE
- Flagellar M-ring protein
- Flagellar basal-body rod protein FlgC
- Flagellar P-ring protein
- Flagellar hook-length control protein
- Flagellar basal-body rod protein FlgG
- Flagellar hook-associated protein 1
Sequence:
MSIAVTTTDPTNTGVSTTSSSSLTGSNAADLQSSFLTLLVAQLKNQDPTNPMENNELTSQLAQISTVSGIEKLNTTLGSISGQIDNSQSLQASNLIGHGVMIPGTTVLAGTGSEEGAVTTTTPFGVELQQAADKVTATITDKNGAVVRTIDIGELTAGVHSFTWDGTLTDGSTAPNGSYNVAISASNGGTQLVAQPLQFALVQGVIRGNSGNTLDLGTYGTTTLDEVRQII
Protein: Cytochrome P450 81F4 (EC 1.14.-.-) (Q9SZU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in indole glucosinolate biosynthesis. Catalyzes hydroxylation reactions of the glucosinolate indole ring. Converts indol-3-yl-methylglucosinolate (I3M) to 1-hydroxy-indol-3-yl-methylglucosinolate (1OH-I3M) intermediate. This hydroxy intermediates is converted to 1-methoxy-indol-3-yl-methylglucosinolate (1MO-I3M) by indole glucosinolate methyltransferase 1 and 2 (IGMT1 and IGMT2).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Indole glucosinolate O-methyltransferase 1
- Indole glucosinolate O-methyltransferase 2
- Probable 2-oxoacid dependent dioxygenase
- Indole glucosinolate O-methyltransferase 5
- Cytosolic sulfotransferase 16
- Flavin-containing monooxygenase FMO GS-OX5
- Cytosolic sulfotransferase 18
- Transcription factor MYB34
- Flavin-containing monooxygenase FMO GS-OX2
- Probable inactive 2-oxoglutarate-dependent dioxygenase AOP2
Sequence:
MFNYVIILPLALFLLAYKFFFTSKKQRYYLPPSPSYSLPILGHHLLIKPPVHRLFHRLSNIHGPIFYLRLGSRRAVVISSSSLARECFTGQNDVIVSNRPRFLTSKYIAYNYTTIATTSYGDHWRNLRRICSLEIVSSKRLANFLHIRKEEIQRMLTRLSRDARVGKEVELESILYDLTFNNIVRMVTGKIYYGDDVSDKEEAELFKKLFTFITTNSGARHPGEYLPFMKIFGGSFEKEVKAAAKVIDEMLQRLLDECKSDKDGNTMVNHLLSLQQDDPEYYTDIIIKGLMLGIMVASSETSALTIEWAMASLLNHPKVLDKVKLEIDEIIGQDRLIEESDIANLPYLQNVVSETLRLHPAAPVLVPRSTAEDIKIGGYDVPRDTMVMVNAWAIHRDPDLWTEPERFNPERFNGGEGEKDDVRMLIAFGSGRRICPGVGLAHKIVTLALGSLIQCFDWKKVNEKEIDMSEGPGMAMRMMVPLRALCKTRPIMNKLPAYTKV
Protein: Mitoguardin 1 (A0A2R8YFQ8)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
Interaction partners:
Sequence:
MSEETVSESQFSLKTAALRVFDLPLTWYYSLSQIKFSPVAKKLFVVTAVSAISVIFLAHHFKRKRGKKKGKILPWEPEHLILEYTKRAASDKGSSCSSSRQNLTLSLSSTKDKGSQVCNYANGGLFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRNRQAEDEACGSIKLGAGDAIAEENVDDIISTEFIHKLEALLQRAYRLQEEFEATLGASDPNSLADDIDKDTDITMKGNVEDFGLRDTLSIASTDSFASAAELAEHREVRHTYSLESLCHCPFYEEAMHLVEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQVILSESANRIFLAESGRKILSALIVKARKNPKKFEDVFDEMIYFLEQTDHWGSTEMELAARGVKNLNFYDVVLDFILMDSFEDLENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKVNIMFIKYQNGIIF
Protein: Antitoxin MazE6 (P9WJ87)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6.
Interaction partners:
- Endoribonuclease MazF6
- Antitoxin MazE3
- Endoribonuclease MazF9
- Antitoxin MazE9
- Probable antitoxin MazE1
- Probable antitoxin MazE2
- Endoribonuclease MazF3
Sequence:
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDDEW
Protein: DNA ligase (EC 6.5.1.1) (F1Q9E8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA helicase
- X-ray repair cross-complementing protein 5
- Non-homologous end-joining factor 1
- DNA-dependent protein kinase catalytic subunit
- DNA repair protein XRCC4
- DNA repair protein RAD52 homolog
- DNA repair protein XRCC1
- Exonuclease 1
- Protein artemis
- Excision repair cross-complementation group 4.
Sequence:
MESVSKSDAKPQAFVAAQVPFIHLCTVLEKIQKTKLRPDKSKILKEFIDSWRNFHAALHKDNPDTADSFYAVMRLIVPSFERERMAYGIKENMLAKLYIEVLGLPKNGDEANKLLNYRAPTTSQGEAGDFALMAYFVLKKRCTSQGNLSIKEVNDFLDSVAINNASKQKDQVKKSLLHLITQSSALEQKWLIRMILKDMKLGISKETVLQVFHPDAPEFYNVTTDLNKVCRQLHDPSVSLSEVSIDLFSAFKPMLAAVANIRQIEKQMGNRPFYIETKLDGERIQLHKAGDVYKYYTRNSYEYTQQFGASPLEGSLTPYIHNVFSPHVVNCILDGEMMAYNPKTETFMQKGSKFDIKRLVDDSDLQTCFCVFDVLLINNQKFGKEPLKKRYESLETVFSPIKGRIHLVSKSEGRTMQEVVNSLNEAIDNREEGIMVKDPMSIYKPDKRGEGWLKIKPEYVDGLMDELDLLIVGGYWGKGRRSGMLSHFLCAVAEVPSPGEKPTVFHTLCRIGSGYTLKELYDLGVKLAKHWKVYNKNNPPAAILCGTEKPEVYIEPRNSVILQVKAAEIVTSEMYKTDCTLRFPRIERIREDKEWHQCMTLDDLNQFRSKASGKLASRHLNIHEDQPEKKKRKIVAKPKKTIGVIDHFKSQDLSKVAKETDMFEEVEFCVINGDDEHSKAELEKGVARCGGIVVQNPGKDTYCAIAAVQNMRVKNLISSDQHDVVWATWLLECLENKQVIPWQPRHMIHMSPSTREHFAKEYDQYGDSYYVDTSEQQLRDVIERISSAEVKSLSVAQIEAENAWDDLPTSIFRPYSAYFDRCADIGDPKSVICGTCLDTRALEFRFHGGKVVEKLKEGISHVVVEDMKRALDLKTLRRLHAKKFKIVHESWVTDSIKAGHVKDEIDYLI
Protein: SD05793p (SD09244p) (Q8I0S0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSMSGVGIDINQEQELDFINIFHNSQPTAMLTSSEDPYLATYSQATSTSSTTKFITEEPLLADMTSFDISYTSSQELGFGLVEDVSGSFASSCSDVAAAIPAPIQHPIITNIKRSAPAPVESQPTKRSRLMLQIKTELAPAFSPTTPEIINQLLNDDRFEAPTTSTSTSTSNTSISSSTHADIVEDLRSAEEETTTDFSAPNTPHSNYSASSSCAAPTCQTGYGGFLTAPTSPAYSTASTSVFSPSPASGISGKRKRGRPAKDHADGPDPVLMSSMKSEEERKAYQDRLKNNEASRVSRRKTKVREEEEKRAEDTLLAENLRLRARADEVASRERKFKKYLMERQRQKSTYVKQEQD
Protein: WD repeat-containing protein 55 (Q9CX97)
Organism: Mus musculus (Mouse)
Function: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:18769712}. Cytoplasm {ECO:0000269|PubMed:18769712}.
Interaction partners:
- Protein Red
- Ribosome biogenesis protein WDR12
- Tetratricopeptide repeat protein 27
Sequence:
MDPTCEESPAEDSNNEEEDLDSTKAAPRIRDTPEDIVLEAPASGLAFHPTRDLLAAGDVDGDVFVFAYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQLERRISKAHSAPINSVLLVDENALVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCIVPVTENLLCTGSTDGIIRAVNILPNRVVGTVGQHAGEPVEALALSHCGHFLASSGHDQRLKFWDMTQLRTVVVDDYRRRKKKGGPLRALSSKAWSTDDFFAGLREDEEDAKAPEEVVRESDDDDDDSD
Protein: Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (Q01974)
Organism: Homo sapiens (Human)
Function: Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Protein Wnt-5a
- Inactive tyrosine-protein kinase transmembrane receptor ROR1
- Frizzled-1
- Immunoglobulin kappa variable 1-33
- Probable non-functional immunoglobulin heavy variable 3-16
- Vang-like protein 2
- Protein Wnt-11
- Frizzled-2
- Frizzled-5
- Frizzled-4
Sequence:
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA
Protein: Allatostatin A receptor 1, isoform B (Allatostatin A receptor 1, isoform D) (Allatostatin receptor) (FI18263p1) (Galanin receptor) (Q9U721)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- IP03705p
- Allatostatin-A
Sequence:
MAGHQSLALLLATLISSWPKASWGATGNGSIISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTEEEIWSLVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVVWCGSPPPLMTNQQVTKTTRTATGNGTSNIEML
Protein: Amino acid transporter, putative (Q57WK5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MTNQSSGGNDRGRRDTDPFAHAGDVKLSSDAIALDVTQKGQDDVVKEVKPSLFTVLLEKFIPHGGLWSCALNLASATLGAGICSLPTGFNLSGIVMSCIYLVCVAVGTVYSLNLLAKVAVKTGSRNYGEAARMVMGPLTGYYAAALMIAMCFGGNVAYIIIIGIILKAVLNRDGVPEYLKSESGNRLMTSMVWLVIILPMCIPKQVNSLRHLSFVGVMFIVYFSCVVIGHSINKIINEGVADGIVYMRTGNSALDGLSLFLFSFICQSNAFEIFREMKHRSPQRFTIYGTVGMSICAVLYFLVGLFGYLEFGGDAIDTVLSLYDPGENVALAIAYIGVAIKITVAHALHAIPIRDGLYHCVGWHVDTVPYWKHVVVVVTINFTSLIIGLFIPKASTVFGLVGAFCGGHIGLVLPPLFYMYSGGFTREKVGNIDFFGAYLLLFVGVVAVVFGTVSTIYNTVP
Protein: RING finger protein 145 (Q7ZWF4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- GTP:AMP phosphotransferase AK3, mitochondrial
- Rho guanine nucleotide exchange factor 3
- EH domain-containing protein 3
- UbiA prenyltransferase domain-containing protein 1
Sequence:
MAMKARLESVLNVGLRIPSIMLLEVLYRWDVSSFFQKIQRSSLNNNPVFQYKYIALYLHYVGYILSLVLLTLPRQHLVQLYLYVLTALLLFAGHQLSRDYVRGELDSGYEGPLYLEPLSMNRFTTALIGQVVVCTLCSCVMQTRQIWLFSAHLLPLVARLCLVPLETIVFINRFAMIFTGLEVLYFIASNLLVPYNLAKTAYRELVQVVEVYGLLALGMSLWNQLVLPVLFMCFWLVLFALQIYTYFSTRDQPPSRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDNAMHRGMTEGITLLILAVQTGLIELQVIHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFRMDFWLLIIISSSILTSLQVLGTLLIYVLFMVEEFRKAPVENMDEVIYYVNGTYRLLEFLVAVCVVAYGVSETLFGEWTVMGSTIILVHSYYNVWLRAQLGWQSFLLRRDAVHKIQSMPTASTLQLQQHNDICSICFQDMKSAVITPCSHFFHAACLKKWLYVQETCPLCHGQLKSQLQPTSSPGTPTQGTPAANQNPREVEQEQRQPQVELNTEEGIRAEEMKTSAEQKLGMDLLPGSLNTQPKECDLVAEGSAGTASNLKGDDYYDDDDVSTSDVNCAS
Protein: Solute carrier organic anion transporter family member (B4DJE6)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU362056}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU362056}.
Interaction partners:
Sequence:
MENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETKVKGKENECKDIYQKSTVLKDDELKTKL
Protein: Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (Q6PJG9)
Organism: Homo sapiens (Human)
Function: Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity).
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase S
- Disks large homolog 4
- Interleukin-1 receptor accessory protein-like 1
Sequence:
MAPPLLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGRDAEASPAPLVLSFSGNPLHCNCELLWLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEATARVELRVLALPHGGNSSAEGGRPGPSDIAASARTAAEGEGTLESEPAVQVTEVTATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPASPLCHALQAHVLGGTLTVAVGGVLVAALLVFTVALLVRGRGAGNGRLPLKLSHVQSQTNGGPSPTPKAHPPRSPPPRPQRSCSLDLGDAGCYGYARRLGGAWARRSHSVHGGLLGAGCRGVGGSAERLEESVV
Protein: F-actin-capping protein subunit alpha-1 (CapZ alpha-1) (P47753)
Organism: Mus musculus (Mouse)
Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0PFK5}.
Interaction partners:
- F-actin-capping protein subunit beta
- Protein S100-B
- Capping protein, Arp2/3 and myosin-I linker protein 2
- F-actin-capping protein subunit alpha-2
- Dynactin subunit 2
- WASH complex subunit 5
- Dynactin subunit 1
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- Myotrophin
- Dynactin subunit 4
Sequence:
MADFEDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQFTPVKIEGYDDQVLITEHGDLGNSRFLDPRNQISFKFDHLRKEASDPQPEDVDGGLKSWRESCDSALRAYVKDHYSNGFCTVYAKTIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPSAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSVTVSNEVQTTKEFIKIIESAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
Protein: Putative glycerol-3-phosphate transporter 1 (G-3-P transporter 1) (Glycerol-3-phosphate permease 1) (AtG3Pp1) (G-3-P permease 1) (Protein PHOSPHATE STARVATION-INDUCED GENE 3) (AtPS3) (Q9C5L3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Inorganic pyrophosphatase 1
- Adenylyl-sulfate kinase 2, chloroplastic
- Adenylyl-sulfate kinase 1, chloroplastic
- ATP sulfurylase 1, chloroplastic
- 5'-adenylylsulfate reductase 2, chloroplastic
- Adenylyl-sulfate kinase 3
- HAD superfamily, subfamily IIIB acid phosphatase
- Putative U-box domain-containing protein 50
- Putative F-box protein PP2-B6
- 5'-adenylylsulfate reductase 1, chloroplastic
Sequence:
MGSLMQSEPEMEKKPIGIRFLERIKGSKLSYSAYQAIVLIVTFLAYASYHAARKTTSIVKSALDPQSPDTGLNSLLLRFTSFGSSVKEEGGWAPFNGPDGTVLLGEIDVAFLAVYAFGMYFAGHLGDRMNLRIFLTVGMIGTGLFTSLFGVGYWGNIHSFYYFLIMQMLAGLFQSSGWPSVVAVVGNWFNKKKRGLIMGIWNAHTSVGNITGSLIAAAMLRYGWGWSFVVPGVIIVVIGLVNYAFLPVSPENVGAERDEVLDSSSEKIGNSVNEPLLLSSSDSETDDKKRAVGFIEAWRIPGVAPFALCLFFAKLVAYTFLYWLPFYVSHTAIEGEYLSDETAGNLSTMFDVGGVVGGIMAGYISDRIGARAITAASFMYCSIPALFFYRSYGHVSLLANASLMFLTGMLVNGPYALITTAVSADLGTHSSLKGNSRALATVTAIIDGTGSVGAAVGPLLTGYISSRGSWTAVFTMLMGAAFVAGLLLTRLVMAEVAEKIAESRPSEECRSPVDYVQDHVMEV