wanglab/gogpt-training-data huggingface dataset:
Protein: serine C-palmitoyltransferase (EC 2.3.1.50) (Q8ILT9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- NAD
- GDP-L-fucose synthase
- Delta-aminolevulinic acid dehydratase
- indole-3-glycerol-phosphate synthase
Sequence:
MHLKGLMDYNYFLGLEVLQNFDIVNYLIAGIVLLALILAVFNEDASAGSPRLSWVLGEFLPIQHSIFALNSNVEKKLFRKRSSKIYTFITCLYNLFVELRNSITEGNFIMLVKGWFLKVLNKIILYKNLLLLKYRSQSKRHLFYMLVKKKYNLPIQKEENEMQSYLDAKRELIRLNRWSFMWRVSNVKNEFLLCEKRKARPISSYSYLDFIREPLVQNNAIQAAMEWSTGNHGPRMLGGNSQILRDLEKVVGNFFGRNDSILAVCGFLACMSGIVAVATHEDIILYDSRTHACVKMGIQICGAKAYSFKHNDYNHLEVLLIKYRYKYRNCWVCIESVYSMDGDIPHLPTFKKLCIQHKAKLYVDEAHGLGVLGKTGRGIEEHFNMPGTADIIVGTFSKSIGGVGGYIVASDEVIEFLDFHCIGNVFSAPLPAYCAGGALKAFELIDTQPWRIQKLKFNTKYLRNGLKTGMGHWPKDYPESYKYIIEGDDATSVIPVIFPNDPDRLFKICNLLLKMNWMISAVVYPACPLKYPRFRVTATSAYTIEYMNEFISDIVRATVRVKPSPLDTQLII
Protein: Ubiquitin-protein ligase E3A (EC 2.3.2.26) (F1M7B8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR037201}. Nucleus {ECO:0000256|PIRNR:PIRNR037201}.
Interaction partners:
- Cellular tumor antigen p53
- Tuberin
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Catenin beta-1
- Hamartin
- Transcriptional repressor NF-X1
- Disks large homolog 1
- Proteasome
- Protein scribble homolog
- Disks large homolog 2
Sequence:
MATACKRSSGESQSEDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGASNNSEIKMNKKEEFKEVDYLTEEKVYEIYEFCREREDYSPLIRVIGRIFSSAEALVQSFRKVKQHTKEELKSLQEKDEDKDEDEKEKAACSAAAMEEDSEASSSRMGDSSQGDNNVQKLGPDDVTVDIDAIRRVYSSLLSDEKIETAFLNALVYLSPNVECDLTYHNVYTRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYSADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGDVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETEIGVKTLDCRKPLISFEEFINEPLNDVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATRLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFCDLGDSHPILYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVSLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML
Protein: 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (EC 2.3.1.29) (Glycine acetyltransferase) (P0AB77)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
Interaction partners:
- L-threonine 3-dehydrogenase
- Low specificity L-threonine aldolase
- Serine hydroxymethyltransferase
- Glycine dehydrogenase
- NADP-dependent 3-hydroxy acid dehydrogenase YdfG
- ATP-dependent dethiobiotin synthetase BioD 1
- Protein HtrL
Sequence:
MRGEFYQQLTNDLETARAEGLFKEERIITSAQQADITVADGSHVINFCANNYLGLANHPDLIAAAKAGMDSHGFGMASVRFICGTQDSHKELEQKLAAFLGMEDAILYSSCFDANGGLFETLLGAEDAIISDALNHASIIDGVRLCKAKRYRYANNDMQELEARLKEAREAGARHVLIATDGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVGFVGENGRGSHEYCDVMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNSLAPAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVAQKFARELQKEGIYVTGFFYPVVPKGQARIRTQMSAAHTPEQITRAVEAFTRIGKQLGVIA
Protein: V-type proton ATPase subunit D (V-type proton ATPase subunit d) (Vacuolar proton pump subunit D) (Q9H3H0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000256|ARBA:ARBA00029434}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029434}.
Interaction partners:
Sequence:
MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKIXNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEKDEDLLFE
Protein: peptidoglycan lytic exotransglycosylase (EC 4.2.2.n1) (Murein hydrolase A) (Q9JPQ6)
Organism: Neisseria meningitidis
Interaction partners:
Sequence:
MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPGRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP
Protein: Glutathione S-transferase (EC 2.5.1.18) (A0A140VJK4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
Protein: CBS domain-containing protein CBSCBSPB4 (Q0WLC7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- DUF21 domain-containing protein At4g14240
- Putative DUF21 domain-containing protein At3g13070, chloroplastic
- Pentatricopeptide repeat-containing protein At5g10690
- Probable arabinose 5-phosphate isomerase
- CBS domain-containing protein CBSX6
- CBS domain-containing protein CBSX2, chloroplastic
- Coatomer subunit epsilon-2
- CBS domain-containing protein CBSX1, chloroplastic
- GMP synthase
Sequence:
MANQGGPSRKSLSFSGHSFQGRKKASENEGGGGGGSDLLPRRSLTSSRSSISLSGERSGERTVKRLRLCKALTVPDSTTLFEACRRMAARRVDALLLTDSNALLCGILTDRDIATKVIAKQLNLEETPVSKVMTKNPVFVLSDTIAVEALQKMVQGKFRHLPVVENGEVIALLDIAKCLYDAIARMERSVEKGKAIAAAVEGVEKNWGTSIAGPNTFMETLRERIFKPSLSTIIPENTKVLKVGLDETVLGVTMKMVEYQSSAAMVMVENKLVGILTSKDILMRVISQNLPQETTTVEKVMTPNPESATVDMAIVEALHIMHNGKFLHLPVLDKDGDVVAVIDVIHITHAAVTTAGSTAGINNETANSMMQKFWDSAMALSPNEDGDETRSEEESMKLSSEIEVTKSFSYPNTFAFKLQDKKGRMHRFMCETQSLTTLITAILQRMGDDIEPDNLPQIMYEDEDNDKVVLASDNDLGAAVEHAKSIGWKGLKLHLDYTEERGHRRGLSSEDMDYDQSNSWAAAYKTVAAGAALAAGLGVLVYLKRNSN
Protein: Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) (Q9WUK4)
Organism: Mus musculus (Mouse)
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cell cycle checkpoint protein RAD17
- Replication factor C subunit 5
- Replication factor C subunit 4
- Replication factor C subunit 3
- Replication factor C subunit 1
- Chromosome transmission fidelity protein 18 homolog
- Proliferating cell nuclear antigen
- Sister chromatid cohesion protein DCC1
- Chromosome transmission fidelity protein 8 homolog
- ATPase family AAA domain-containing protein 5
Sequence:
MEVQESGCDPSESGAQEPSPVPSKTAGHYELPWVEKYRPLKLNEIVGNEDTVSRLEVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQVLTRLMNVIEKEKVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGYINSENVFKVCDEPHPLLVKEMIQHCVDANIDEAYKILAHLWHLGYSPEDVIGNIFRVCKTFPMAEYLKLEFIKEIGYTHMKVAEGVNSLLQMAGLLARLCQKTMAPVAS
Protein: Ferric leghemoglobin reductase-2 (O81413)
Organism: Glycine max (Soybean) (Glycine hispida)
Interaction partners:
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- 2-oxoglutarate dehydrogenase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Sequence:
MAMANLARRKGYAVVLSSRSSLCLTRWRGFASGSDENDVVVIGGGPGGYVAAIKAAQLGLKTTCIEKRGTLGGTCLNVGCIPSKALLHSSHMYHEAKHAFANHGVKFSSVEVDLPAMMAQKDKAVSNLTKGIEGLFKKNKVNYVKGYGKLVSPSEVSVDTTEGGNTVVKGKHIIIATGSDVKSLPGITIDEKKVVSSTGALALTEIPKRLIVIGAGYIGLEMGSVWGRLGSEITVVEFASEIVPTMDAEVRKQFQRSLEKQGMKFKLKTKVVGVDTSGDGVKLTLEPAAGGDQTTLEADVVLVSAGRTPFTAELGLDKIGVETDKIGRILVNERFATNVSGVYAIGDVIPGPMLAHKAEEDGVACVEYIAGKVGHVDYDKVPGVVYTMPEVASVGKTEEQVKELGVEYRVGKFPFLANSRAKAIDNAEGLVKILAEKETDKILGVHIMAPNAGELIHEAAIALQYDASSEDIARVCHAHPTMSEAVKEAAMATYDKPIHI
Protein: NAD(P)-linked oxidoreductase superfamily protein (Q949S6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAASSSIPPSTAVTSVVRKSLLLSTTFSFPASSLSPSTKLPQRHIQRLLLASSSASASTVPSDSKPAKKETVYFDGGAHYGDLLANLILGLTILWLPLTLAAVSRAFNLRYRFTNLRVTVISGLTGDDRSDFSYKVIKDVQVVPRFIGEWGDIIITLKDGTKVDLRSVPKFREIAKYCLSMADQPAVLKESGAKGF
Protein: Doublesex cognate 73A (RE23490p) (Q9VV62)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Lipase
Sequence:
MVRLSAAWSCCFLALIALVSTVASSAADYPGVIELVGYSNRRARTYFQEQPRSNPNPKPGLTSAKTRADIETVKRNIRKYDRLLELDTKNLPEQQKDMLARIVERVARLKESLDIEEQQFNQQEATSSRSSSSTTTSASSTQESQTEAETELDQEPIEQSTQLPTGATEAETDPTLILDETTLLELQNTMNEQAAMSTIMKEMPTTTDMSQQEAESEVPDEEGETTSPNLTTQSEAATTSDESLTDSTDPDDQFVAARSNNNIAAITAADDADGTTTTTANTGSQQRTLTTMGKLKNRATKRPFAHKVTAALKRGGQRPSSVSAAAASAAAASKPSSSTTTAAAASSTTQKQKLATNSFQQKQQQAKPLQKVTPSIGGGGSSNPSSASIPSATTNSAAPSLPIEQLYTRTPQANIPLAAAAAAATSSASAAAAAGSAGSGATPATYSSQHDSMVYDGHVNASALIDSLNTNAREEYYQQKLGAGNKDNKKTATAKPTKYHYYPHNQHIYLLPECAIQQVCNAVYVRLNYTQPLCACPSRYRDPCSASLNEDDQHTTKLVGDTKKKAITLAKTCEATTEMRECRSPKDWSLLALQNTRTGKSHYLVICRCPDHFKMEGPMAHDQPTYASVPGIRVFGMMCVKPGYSVRKPSNQPPKRYQLQKPFYRPSVGTTVGGQKDSYGRPIYGGSSSSGSSAISSNYQPQDSSFQSGGSSSYQYLNRPESGVSHSSANFRPDQFSINNFPSSNYGRNNERRGDLPPIEAISSGSGTGAEEQPSSSTPAAEEEEARTTVQAEQETEPAEEAVPAATAELTTTAEEAALGSRTRRSLPDTDDYEPEFPWDRVLEFQQSIIWD
Protein: Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) (Q9UBQ7)
Organism: Homo sapiens (Human)
Function: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidizes D-glycerate to hydroxypyruvate.
Interaction partners:
- Alanine--glyoxylate aminotransferase
- 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- Glycerate kinase
- 2-Hydroxyacid oxidase 1
- 2-Hydroxyacid oxidase 2
- Lactoylglutathione lyase
- Glycerol-3-phosphate phosphatase
- Glycine dehydrogenase
- D-amino-acid oxidase
- Alanine--glyoxylate aminotransferase 2, mitochondrial
Sequence:
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLSDHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLLTTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHRTRNTMSLLAANNLLAGLRGEPMPSELKL
Protein: Transmembrane alanine and glycine rich protein (O07219)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MNGQRGQLSTLIGRTLLGLAATAVTAVLLAPTVAASPMGDAEDAMMAAWEKAGGDTSTLGVRKGDVYPIGDGFALDFAGGKMFFTPATGAKYLYGPLLDKYESLGGAADSDLGFPTINEVPGLAGPDSRVSTFSAADNPVIFWTPEHGAFVVRGALNAAWDKLGSSGGVLGAPVGDETYDGEVTAQKFSGGEVSWNRATKEFTTVPAVLAEQLKGLQVAIDPSAAINMAWRAAGGAAGPLGAKKGGQYPIGGDGIAQDFVGGKVFFSPATGANAVEGEILAKYESLGGPVSSDLGFPIANETDGGFGPSSRIVRFSAADKPVIFWTPDHGAFVVRGAMVAAWDKLRGPNGKLGAPVGDQTVDGDVVSQKFTGGMISWNRAKNTFTTDPANLAPLLSGLQVSGQNQPSTSAMPPPGKKFTWHWWWLGAAALGVLLVVMVALVVFGLRRRRRGYDAAAYDDDRAGDVEYGTAADGDWPPDEDFGSEHFGFGDQFPPEPVAPDAGSTPRVSWPRGAGAAVGDAEHLPGEEGYGSDLLSGPSNVGVEEEDTDAVDTTPTPVVSQADLSEVGPDLIVPERVVPETFVPQAFVPEAVAPEAVPPDVHAADLADTGLPAAAVSAAEDRGGRHAAAEPPEPPSAGVRPAIHLPLEDPYQMPNGYPVKASVSFGLYYPPGSALYHDTLAELWFASEEVAQVNGFIRAD
Protein: Hormone receptor 83 (RT11831p) (Q9VI12)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSNFSACAVCGDQSSGKHYGVSCCDGCSCFFKRSVRRGSSYACIALVGNCVVDKARRNWCPSCRFQRCLAVGMNAAAVQEERGPRNQQVALYRTGRRQAPPSQAAPSPTPHSQALHFQILAQILVTCLRQAKANEQFALLDRCQQDAIFQVVWSEIFVLRASHWSLDISAMIDGCGDEQLKRLICEAHQLRADVLELNFMESLILCRKELAINAEYAVILGSHSKAALISLARYTLQQSNYLRFGQLLLGLRQLCLRRFDCALSCMFRSVVRDILKTL
Protein: Tetraketide alpha-pyrone reductase 2 (EC 1.1.1.-) (Protein CINNAMOYL-COA REDUCTASE-LIKE 6) (Q9CA28)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the biosynthesis of hydroxylated tetraketide compounds that serve as sporopollenin precursors (the main constituents of exine). Acts on tetraketide alpha-pyrones and reduces the carbonyl function on the tetraketide alkyl chain to a secondary alcohol function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21193572}.
Interaction partners:
- Type III polyketide synthase A
- Type III polyketide synthase B
- Cytochrome P450 703A2
- Cytochrome P450 704B1
- 4-coumarate--CoA ligase-like 1
- Putative acyl-activating enzyme 19
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Pentatricopeptide repeat-containing protein At4g08210
- ABC transporter G family member 26
- No exine formation 1
Sequence:
MSEYLVTGGTGFIASYIIKSLLELGHTVRTTVRNPRDEEKVGFLWEFQGAKQRLKILQADLTVEGSFDEAVNGVDGVFHTASPVLVPQDHNIQETLVDPIIKGTTNVMSSCAKSKATLKRIVLTSSCSSIRYRFDATEASPLNESHWSDPEYCKRFNLWYGYAKTLGEREAWRIAEEKGLDLVVVNPSFVVGPLLGPKPTSTLLMILAIAKGLAGEYPNFTVGFVHIDDVVAAHVLAMEEPKASGRIICSSSVAHWSEIIELMRNKYPNYPFENKCSNKEGDNSPHSMDTRKIHELGFGSFKSLPEMFDDCIISFQKKGLL
Protein: Prostate and testis expressed protein 14 (Secreted seminal-vesicle Ly-6 protein 1) (SSLP-1) (Q3UN54)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000269|PubMed:16940290}.
Interaction partners:
- Prostate and testis expressed protein 4
- Prostate and testis expressed 10
- Prostate and testis expressed protein 13
- Prostate and testis expressed protein 3
Sequence:
MEKYLLLLLLGIFLRVGFLQALTCVSCGRLNSSGICETAETSCEATNNRKCALRLLYKDGKFQYGFQGCLGTCFNYTKTNNNMVKEHKCCDHQNLCNKP
Protein: FI06405p (Q9W453)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Serine protease K12H4.7
Sequence:
MFGLGQLLAVALLLIFLPSGLRGATTRTHLDTKAIRPRFNADPGRIINGTEASLGATRHQVGIRKALNDGYFFGTGHLCGGSLIRPGWVLTAAHCFVDQIIYDGTFVPKEEFIVVMGNLDRYNRTNTLTFTIEERIMQLDKFDLSTYDKDIALLMLNGTVPTGHPTIRPIALNRFAIPEGVVCQVTGWGNTEDGYVSDILMTVDVPMISEEHCINDSDLGHLIQPGMICAGYLEVGEKDACAGDSGGPLVCQSELAGVVSWGIQCALPRLPGVYTEVSYYYDWILQNMGENGEGSGEESGEGSGEGSGEGSGEGSGEGSGDDGSGDDEDGSGDGGGAMAAVAGSLTLLLPGILALRLMATQF
Protein: Protein kinase, putative (EC 2.7.1.-) (Q57YD1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- glutathione-specific gamma-glutamylcyclotransferase
Sequence:
MLLHYRTLAMATSRKQVVGKYELGKVLASGYFDCRTRICTHIVTGAQYVVRIYSKSTLAEAQWMWDRTRDAIHVMRTLPKHENIIEISELFETESSLYILMQLFAPMHLTKMYTTVGESGQRERVPIQRTKALFLQVVRGLRHMHDCSVVHLGLAPDHVMVNDRDHVKIGNLVSCKYVPKGTKLCRDIRGTMHTVAPEVLRNGEYDPYLADSWSMGVLLYFMLHNGRYPHDGANTTKNILYNRIRPPDPKLPAEALNLLQQLLSHNPGSRMRVEQIADHPFFATEHKDVDTGRTEQQAARYTGVVPNLWASRTAHIPVVLRAPLKERVQYSGNREDAAAYLIQMCYKAFRGRKRRFSDRFLSTQPRGSINRSRSQVVEVVCPSSRSRRRKNYQTPHGDTEAAFGQERTHLSSQHYQQRWSAVTNTEMQQGELGSRTSSINSGFAKCGEGPADPAEGSSFFGFSGSESEGSPMNATQGSHFNFSLKSGNLPLTLPPLRRQGGPCKLGCDPTLDAPVGTPPNSTFDGPDNASPTTASVCNEVVRAASFRLRVPSMLHLKAAEAFSRDLDLRGPGFTHFNTRVDPGRRCPVCDRPPAQRMNRKQPYLNTPYEYKEGKFTIKTVADSD
Protein: Transposon Ty1-PR1 Gag-Pol polyprotein (Gag-Pol-p199) (TY1A-TY1B) (Transposon Ty1 TYA-TYB polyprotein) (p190) [Cleaved into: Capsid protein (CA) (Gag-p45) (p54); Ty1 protease (PR) (EC 3.4.23.-) (Pol-p20) (p23); Integrase (IN) (Pol-p71) (p84) (p90); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Pol-p63) (p60)] (P0C2I9)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMNTWDTDKYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDTGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSHYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
Protein: Glycosyl hydrolase (Q584E6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGFWPRSLLARDYEVPKRPIFHLEGWDVVQGTDAATYVSGVVPDGVMYGTNGCLGVRHHCESETVGYRTSLYMNGVYHSAPLNAYVDSEALPEEIQVGATVCEVTLDCFIDGESGTLGEAPSQRLNLRDATYSSTSVDVVSGDGGLTFDSTYRQVVSLNELDLWCAETVCTNFSIDALSSGTDFASQNNSESSAKHIEEDMYSTESSTYSVVFIVSVTVSLDDWYLVGGDSTEKLLIESTTSGILVGTETEASCTVECGDRTYKIVPEQQVRNVPEDFYTPHRDCGFSHAAYVSESESEHPHSSRAAWRGTSGSRGRVCFQKQFPYTITPDNVPQKVTLSFHARHHNGGLPLSRPFPSFADVVAEQRLVLDNFWSTFWIDIQRQDELPPNRMKLGLIFNSFRLFCVSRNLQNGLPQAGCSTTKSNLLYDLQQYVYHGIYYILTSPSSALALLRSLYCMLSQARMNALRLSLEHGAVYPRRTITGTECWHCSTLNNARFHVNAEVGYIINMYFSAVESIATSDRLWLLELMLETARVWSQVGEWVENEGVFRLDNIAGPDEYNGNAAGNFYVHLSAKLHLRNAYNLYEEQQKIVGDEAIFCLLQGINMDISELENFRTISNEIVVRRDNHLDVFLVHDHFDTLKEWKGERPKHPLSMNYHPLAIYRHKVVNIPEVLLGMLLYPAEFERKDLLQNLSYYAPLCTHDSAESLAIVACVEFRANGRFTHGMPLLCSLASLDLDNIIYAADEGLDFGAMSATWIAVVMGIGGVKITSRSLHLDPSFPAGLSVLSFTLHWRGATLRTRVEKDCITYDLMAGDSIRFIHASRHRIHLHSGCRQSVARKQVAIPQPMSSMHGEFAGAIFLCETLFDSVMEMNFIAWGKTLESLYENYRALHLRHIPPLTAEEFVDKVIYQAEHREIAFSGIHNVLLDRGIDLPLGSPDDAEIVETRYGLANAKVAELEEMWSREAPCVNPAMRALLRDLEDNGIPLALVSYSRTLKTLMQYHPEEALRFLTAIDGDEAHERHIKSRPHLDIFVRAAEKIHVEPSRCLIFSSHIDSNFKVSELSYFRMVFDVEDPFAARVRGSKTCEYPSMLRPAAADGDVRPLVINLKRDKFPTTVDGLESILCGPVASGSDLAAAGDAPPSDPCS
Protein: Potassium channel AKT1 (Q38998)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins. Is essential with POT5/HAK5 for high-affinity potassium uptake in roots during seedling establishment and postgermination growth under low potassium conditions.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16814720}; Multi-pass membrane protein {ECO:0000269|PubMed:16814720}.
Interaction partners:
- Potassium channel KAT3
- CBL-interacting serine/threonine-protein kinase 23
- Calcineurin B-like protein 9
- Calcineurin B-like protein 1
- Calcineurin B-like protein 10
- Potassium transporter 5
- CBL-interacting serine/threonine-protein kinase 6
- Calcineurin B-like protein 4
- Sodium transporter HKT1
- Sodium/hydrogen exchanger 7
Sequence:
MRGGALLCGQVQDEIEQLSRESSHFSLSTGILPSLGARSNRRVKLRRFVVSPYDHKYRIWEAFLVVLVVYTAWVSPFEFGFLRKPRPPLSITDNIVNAFFAIDIIMTFFVGYLDKSTYLIVDDRKQIAFKYLRSWFLLDLVSTIPSEAAMRISSQSYGLFNMLRLWRLRRVGALFARLEKDRNFNYFWVRCAKLVCVTLFAVHCAACFYYLIAARNSNPAKTWIGANVANFLEESLWMRYVTSMYWSITTLTTVGYGDLHPVNTKEMIFDIFYMLFNLGLTAYLIGNMTNLVVHGTSRTRNFRDTIQAASNFAHRNHLPPRLQDQMLAHLCLKYRTDSEGLQQQETLDALPKAIRSSISHFLFYSLMDKVYLFRGVSNDLLFQLVSEMKAEYFPPKEDVILQNEAPTDFYILVNGTADLVDVDTGTESIVREVKAGDIIGEIGVLCYRPQLFTVRTKRLCQLLRMNRTTFLNIIQANVGDGTIIMNNLLQHLKEMNDPVMTNVLLEIENMLARGKMDLPLNLCFAAIREDDLLLHQLLKRGLDPNESDNNGRTPLHIAASKGTLNCVLLLLEYHADPNCRDAEGSVPLWEAMVEGHEKVVKVLLEHGSTIDAGDVGHFACTAAEQGNLKLLKEIVLHGGDVTRPRATGTSALHTAVCEENIEMVKYLLEQGADVNKQDMHGWTPRDLAEQQGHEDIKALFREKLHERRVHIETSSSVPILKTGIRFLGRFTSEPNIRPASREVSFRIRETRARRKTNNFDNSLFGILANQSVPKNGLATVDEGRTGNPVRVTISCAEKDDIAGKLVLLPGSFKELLELGSNKFGIVATKVMNKDNNAEIDDVDVIRDGDHLIFATDS
Protein: DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3) (Q8T8S1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000269|PubMed:26792857}. Note=Predominantly localizes to the cell membrane in eye imaginal disk cells. {ECO:0000269|PubMed:26792857}.
Interaction partners:
- Nedd8-conjugating enzyme UbcE2M
- Cullin homolog 1
- RING-box protein 1A
- IP10645p
- Ubiquitin-like protein NEDD8
- LD21810p
- Cullin 3, isoform F
- Cullin 6
- RING-box protein 1B
- Cullin-5
Sequence:
MGNCLKCFQSAAEQSMPTNASSPNSHNSNSNACQTATSLANCYESVGINPNANERCALETDELLSSRTPLKPAKANNCDTKRNSFKSLGLLNGSAPTMSDIITTAVQESMEVSHQTLSKLFDVYKDPDDEEMILTDGIERLCNDLNYQPDEFAILVLAWCLDASQMCRFTKVEFIEGLHKMRADTIDSIRVRLEQTIEMLKADAEMFKQLYRFTFRFGLEPDQRVLSLEMAIDLWKLVFTVQTPDLFSNWIHFLEKHPNIRRIPKDTWNMYLNFTEQCDIQNYDDTEAWPSLFDDFVDYEKSRALVSSGIHDDDNNNDDPLQSHVKAEDPGLVS
Protein: tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (Q581V8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Tryptophan--tRNA ligase, cytoplasmic
- Tyrosyl/methionyl-tRNA synthetase, putative
Sequence:
MRRASHVCTSCELLGFQKQFLMLSNRGNSSGDNDVIDTSGGKFRNGNGDGKDDDVVTPWNVSATGVRGVNYDRVLVRFKSQPIGEPLLKRMQDVCVERVKCNNSERGHNAERSAVGEEVQPLHHFFRRGIAFSHRDFDIALTNVQEALRSGTQGAYLYTGRGPSTRTMHLGHVIPFMLTRYLQDALGLPLVIQITDDEKFFFRDVPLHDNRCSDGIDIVTENIKDIIAFGFDPKRTFIFRNTSYMGSMYPTVVRLQRTMTLSAVKNTLGLIDNDNIGKASFAATQAAPCFSSSFPCILGEQDFEKPLQCIVPCAIDQDPYFVLARASASRMKYRAPALLHTKFLPALKGMRLKMSSSAEESGVITLHDSPEQVQKKMKKAFSGGSGTLDDMKTKGVDLEADVAYQFIRFFSPDDEMVGEVSAKYVVGEMNSCYVKSLAADVVVRHVLRNWQAKRKLVTDEEVRRFTEVRNIMA