wanglab/gogpt-training-data huggingface dataset:
Protein: Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 (EC 3.6.4.13) (DEAH RNA helicase homolog PRP16) (Protein CLUMSY VEIN) (Protein EMBRYO DEFECTIVE 3011) (Protein PSR1-INTERACTING PROTEIN 1) (F4K2E9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in pre-mRNA splicing by mediating structural transitions of the spliceosome during the catalytic step. Facilitates expression of genes involved in auxin-mediated development including male-gametophyte transmission, apical-basal patterning of embryonic and gynoecium development, stamen development, phyllotactic flower positioning, and vascular development. Also involved in root-meristem maintenance and planar polarity of root-hair positioning. Acts as a component of RNA silencing that regulates distinct classes of endogenous small RNAs. Functions as a positive regulator of plant immunity.
Subcellular location: Nucleus {ECO:0000269|PubMed:25384462, ECO:0000269|PubMed:25902521}. Note=Binds to the spliceosome. {ECO:0000250|UniProtKB:P15938}.
Interaction partners:
- Pre-mRNA-splicing factor SYF2
- Cell division cycle 5-like protein
- Tetratricopeptide repeat
- Cwf15 / Cwc15 cell cycle control family protein
- AT3G18790 protein
- U2 small nuclear ribonucleoprotein A'
- Transducin/WD40 repeat-like superfamily protein
- Pre-mRNA-processing factor 17
- Pre-mRNA splicing factor domain-containing protein
- At2g44200/F6E13.34
Sequence:
MGVDPFKTTETLEADKETNGGVPVKDKLTFKAPERKSRLGLDARAIEKKDNAKTEGEFKVPKKSAISVTSSLDEEDKSDVSGLDFGTENTRPVHSSRRYREKSSRSQSAQESTVTTENAGTSDISITPRTLSCTSSYERGGSNRHREEHRRDRSETPRSRQRNTYDEMDHYRRRESYRQSDRDYHGEKRRRYNSDWRTPGRSDWDDGQDEWERSPHGDRGSSYSRRPQPSPSPMLAAASPDARLASPWLDTPRSTMSSASPWDMGAPSPIPIRASGSSIRSSSSRYGGRSNQLAYSREGDLTNEGHSDEDRSQGAEEFKHEITETMRVEMEYQSDRAWYDTDEGNSLFDADSASFFLGDDASLQKKETELAKRLVRRDGSKMSLAQSKKYSQLNADNAQWEDRQLLRSGAVRGTEVQTEFDSEEERKAILLVHDTKPPFLDGRVVYTKQAEPVMPVKDPTSDMAIISRKGSGLVKEIREKQSANKSRQRFWELAGSNLGNILGIEKSAEQIDADTAVVGDDGEVDFKGEAKFAQHMKKGEAVSEFAMSKTMAEQRQYLPIFSVRDELLQVIRENQVIVVVGETGSGKTTQLTQYLHEDGYTINGIVGCTQPRRVAAMSVAKRVSEEMETELGDKIGYAIRFEDVTGPNTVIKYMTDGVLLRETLKDSDLDKYRVVVMDEAHERSLNTDVLFGILKKVVARRRDFKLIVTSATLNAQKFSNFFGSVPIFNIPGRTFPVNILYSKTPCEDYVEAAVKQAMTIHITSPPGDILIFMTGQDEIEAACFSLKERMEQLVSSSSREITNLLILPIYSQLPADLQAKIFQKPEDGARKCIVATNIAETSLTVDGIYYVIDTGYGKMKVFNPRMGMDALQVFPISRAASDQRAGRAGRTGPGTCYRLYTESAYLNEMLPSPVPEIQRTNLGNVVLLLKSLKIDNLLDFDFMDPPPQENILNSMYQLWVLGALNNVGGLTDLGWKMVEFPLDPPLAKMLLMGERLDCIDEVLTIVSMLSVPSVFFRPKERAEESDAAREKFFVPESDHLTLLNVYQQWKEHDYRGDWCNDHYLQVKGLRKAREVRSQLLDILKQLKIELRSCGPDWDIVRKAICSAYFHNSARLKGVGEYVNCRTGMPCHLHPSSALYGLGYTPDYVVYHELILTTKEYMQCATSVEPHWLAELGPMFFSVKDSDTSMLEHKKKQKEEKSGMEEEMEKLRRDQVESELRSKERERKKRAKQQQQISGPGLKKGTTFLRPKKLGL
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Complex I subunit B13) (Complex I-13kD-B) (CI-13kD-B) (NADH-ubiquinone oxidoreductase 13 kDa-B subunit) (Q9CPP6)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Peripheral membrane protein {ECO:0000269|PubMed:38575788}; Matrix side {ECO:0000269|PubMed:38575788}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 1
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 4
- NADH-ubiquinone oxidoreductase chain 1
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 10
Sequence:
MAGLLKKTTGLVGLAVCDTPHERLTILYTKTLDILKHFPKHAAYRKYTEQITNEKLDMVKAEPDVKKLEALLQGGEVEEVILQAEKELSLARKMLKWKPWEPLVEEPPANQWKWPI
Protein: Aclacinomycin methylesterase RdmC (EC 3.1.1.95) (Q54528)
Organism: Streptomyces purpurascens
Function: Involved in the biosynthesis of the anthracycline aclacinomycin which is an aromatic polyketide antibiotic that exhibits high cytotoxicity and is widely applied in the chemotherapy of a variety of cancers. Catalyzes the removal of the methoxy group from the C-15 position of aclacinomycin T and A to yield 15-demethoxyaclacinomycin T and A, respectively.
Interaction partners:
Sequence:
MSERIVPSGDVELWSDDFGDPADPALLLVMGGNLSALGWPDEFARRLADGGLHVIRYDHRDTGRSTTRDFAAHPYGFGELAADAVAVLDGWGVDRAHVVGLSMGATITQVIALDHHDRLSSLTMLLGGGLDIDFDANIERVMRGEPTLDGLPGPQQPFLDALALMNQPAEGRAAEVAKRVSKWRILSGTGVPFDDAEYARWEERAIDHAGGVLAEPYAHYSLTLPPPSRAAELREVTVPTLVIQAEHDPIAPAPHGKHLAGLIPTARLAEIPGMGHALPSSVHGPLAEVILAHTRSAA
Protein: Sodium/hydrogen exchanger (D5SHT8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MQVEPQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLMPKYLSSSFTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALAIRNTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPVGVDDETEQLNNYQVHSSDGYLQDVEGGGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTKYMKPLLTHSRPTLLETLPVCCNPIARLLTTTQQLTQDGSEFRRVDSDSDICIDNDTGNGLSQDGSGAAPGVGRRNSLSRVSIKYTADNHHLLASYRNIE
Protein: Rho-related GTP-binding protein RhoH (Q9D3G9)
Organism: Mus musculus (Mouse)
Function: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils (By similarity). Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17028588}. Cell membrane {ECO:0000269|PubMed:17028588}; Lipid-anchor {ECO:0000269|PubMed:17028588}; Cytoplasmic side {ECO:0000269|PubMed:17028588}. Note=Colocalizes together with ZAP70 in the immunological synapse.
Interaction partners:
- Rho-related GTP-binding protein RhoB
- Tyrosine-protein kinase ZAP-70
- Intersectin-2
- Intersectin-1
- Proto-oncogene tyrosine-protein kinase LCK
- Rho GDP-dissociation inhibitor 1
- Rho GDP-dissociation inhibitor 2
- Rho GDP-dissociation inhibitor 3
- Rho-associated protein kinase 1
- Rho-associated protein kinase 2
Sequence:
MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKNKWISEIRSNLPCTPVLVVATQTDQREVGPHRASCINAIEGKRLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRKLFSINECKIF
Protein: Somatotropin (Growth hormone) (P01248)
Organism: Sus scrofa (Pig)
Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Subcellular location: Secreted.
Interaction partners:
- Growth hormone receptor
- Somatoliberin
- Prolactin
- Appetite-regulating hormone
- Leptin
- BPI fold containing family A member 2
- Peripherin 2.
- Crystallin gamma D
- Neuropeptide Y receptor type 2
- Guanylate cyclase
Sequence:
MAAGPRTSALLAFALLCLPWTREVGAFPAMPLSSLFANAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKDEAQQRSDVELLRFSLLLIQSWLGPVQFLSRVFTNSLVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNLRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF
Protein: Glucokinase regulator (H7C1B4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
PITEKSNPLTQDLDKADAENIVRLLGQCDAEIFQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARHPFPPPRILRSLTVFPSLRAPHYQITSLLFSMSVVTLISE
Protein: Heavy metal tolerance factor 1 (G5EFD4)
Organism: Caenorhabditis elegans
Function: May play a pivotal role in the detoxification of heavy metals such as cadmium but do not depend exclusively on phytochelatins (PC) synthesis.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:15840570}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:31053883}. Late endosome {ECO:0000269|PubMed:31053883}. Recycling endosome {ECO:0000269|PubMed:31053883}.
Interaction partners:
- Glutathione gamma-glutamylcysteinyltransferase
- Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein
Sequence:
MGFSPFLDECRAEGLWPIGPSCNKIISFGVYTFFIVVNFIVLCIPNSNSANNNYRRMTDDDASSTSKLTISKILSICTIFAVICQSIFYFCFTFYFHPYTHLLLAFCVSKLFFWILSLCSFSKWRNQPSTPISLAFAFSAALLIHCIPLTDWKKYFEPTSKNRGDLTFYIIELALVTVVFFFTIVTGLFNFSGCSSRESAWNNLSKKVVTVAPYIWPTKSISLQLRVVFCLFLLIIGRLINVSLPILSKWIVDELATPDTFQYSLLFLATFLKFLQGNGAMGGFLNTVRTYLWIPIQQYTTRELEVELFKHLHSLSLRWHLSRKTGQVLRVMDRGTSSVNNILNYILFNVVPTIADIVIAVIFFFSAFNAYFGLIVFGTMALYLTVTISITEWRTQYIREANEKDNATSAIATDSLINYETVKYYGNEEFEVNRFKNAIESYQVTEWKTQASLAFLNCLQNAIIGIGMIGGSVFVVYMIVHEKTLTVGDYVLFTTYLLQLYTPLNFFGTIYRVIQKAFVDMENMFDLMNDEVEVKDLPHALPYTDPRGTISVKNLTFEYNTGLPVIKNISFEIGNGQTVALVGSSGSGKSTLIRLLFRLFESTEGSIEFDGIDVRNYTMHSLRQQIGIVPQDTVLFNDTIMYNIRFGRPDASDEEVIEAAKAAMIHEKITSLPEGYATMVGERGLKLSGGEKQRVAIARTILKKPQFIFLDEATSALDTPTERAIQKCLEKLCKSRTGVVVAHRLSTVVNADLILVLDKGIILERGNHKELLAQQGTYASMWEAQIAEQRAKSIELGEELP
Protein: Glypican-6 [Cleaved into: Secreted glypican-6] (Q9Y625)
Organism: Homo sapiens (Human)
Function: Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.; SUBCELLULAR LOCATION: [Secreted glypican-6]: Secreted, extracellular space {ECO:0000250}.
Interaction partners:
- Glypican-4
- Syndecan-2
- Glypican-5
Sequence:
MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
Protein: Elongation factor Tu (EF-Tu) (EC 3.6.5.3) (P23568)
Organism: Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00118}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL19
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein bL21
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS12
Sequence:
MAREKFDRSKPHVNVGTIGHIDHGKTTLTAAICTVLAKEGKSAATRYDQIDKAPEEKARGITINSAHVEYSSDKRHYAHVDCPGHADYIKNMITGAAQMDGAILVVSATDSVMPQTREHILLARQVGVPRMVVFLNKCDIATDEEVQELVAEEVRDLLTSYGFDGKNTPIIYGSALKALEGDPKWEAKIHDLMNAVDEWIPTPEREVDKPFLLAIEDTMTITGRGTVVTGRVERGELKVGQEIEIVGLRPIRKAVVTGIEMFKKELDSAMAGDNAGVLLRGVDRKEVERGQVLAKPGSIKPHKKFKAEIYALKKEEGGRHTGFLNGYRPQFYFRTTDVTGSISLPENTEMVLPGDNTSITVELIAPIACEKGSKFSIREGGRTVGAGSVTEVLE
Protein: Ferredoxin 1b (A2BGD1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Cholesterol side-chain cleavage enzyme
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Cytochrome P450, family 17, subfamily A, polypeptide 2
- Cytochrome P450, family 21, subfamily A, polypeptide 2
- Cytochrome P450, family 11, subfamily C, polypeptide 1
- Cholesterol 7-desaturase nvd
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- Fatty acid desaturase 6
Sequence:
MAYRMCVRVLLRSSSLLACHPGSVRSHAEFHHTVPSLCSQSQLNGSSSSKVLVHFVNQSGVKSSVFVTEGETLLDVVIKKNLDFSGFGACEGTLACSTCHLIFEENVFDKLEPMVDEEIDMLDLAYGITKTSRLGCQVTVERWMDGMTVRVPQDIKDQRGKQEAVSSK
Protein: Leucine-rich repeat protein kinase family protein (F4IB63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Dormancy-associated protein homolog 1
- Wax ester synthase/diacylglycerol acyltransferase 4
- FCS-Like Zinc finger 6
Sequence:
MESHRVFVATFMLILHLVQAQDQPGFINVDCGLLPRDSPYNALGTGLVYTSDVGLVSSGKTGKIAKEFEENNSTPNLTLRYFPDGARNCYNLNVSRDTNYMIKATFVYGNYDGHKDEPNFDLYLGPNLWATVSRSETVEEIIHVTKSDSLQVCLAKTGDFIPFINILELRPLKKNVYVTESGSLKLLFRKYFSDSGQTIRYPDDIYDRVWHASFLENNWAQVSTTLGVNVTDNYDLSQDVMATGATPLNDSETLNITWNVEPPTTKVYSYMHFAELETLRANDTREFNVMLNGNDLFGPYSPIPLKTETETNLKPEECEDGACILQLVKTSKSTLPPLLNAIEAFTVIDFLQVETDEDDAAAIKNVQNAYGLINRSSWQGDPCVPKQYSWDGLKCSYSDSTPPIINFLDLSASGLTGIIAPAIQNLTHLEILALSNNNLTGEVPEFLADLKSIMVIDLRGNNLSGPVPASLLQKKGLMLHLDDNPHILCTTGSCMHKGEGEKKSIIVPVVASIVSLAVIIGALILFLVFRKKKASKVEGTLPSYMQASDGRSPRSSEPAIVTKNKRFTYSQVVIMTNNFQRILGKGGFGIVYHGFVNGVEQVAVKILSHSSSQGYKQFKAEVELLLRVHHKNLVGLVGYCDEGENMALIYEYMANGDLKEHMSGTRNRFILNWETRLKIVIDSAQGLEYLHNGCKPLMVHRDVKTTNILLNEHFEAKLADFGLSRSFPIGGETHVSTVVAGTPGYLDPEYYKTNRLTEKSDVYSFGIVLLEMITNRPVIDQSREKPYISEWVGIMLTKGDIISIMDPSLNGDYDSGSVWKAVELAMSCLNPSSTRRPTMSQVLIALNECLVSENSRGGASRDMDSKSSLEVSLTFDTDVSPMAR
Protein: Thioredoxin-like 2-2, chloroplastic (Atypical cysteine/histidine-rich thioredoxin 2) (AtACHT2) (Q8LCT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiol-disulfide oxidoreductase that may participate in various redox reactions. Possesses insulin disulfide bonds reducing activity.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:19109414}.
Interaction partners:
- 2-Cys peroxiredoxin BAS1, chloroplastic
- NADPH-dependent thioredoxin reductase 3
- Thioredoxin-like protein CDSP32, chloroplastic
- PLAT domain-containing protein 1
- Peroxiredoxin Q, chloroplastic
Sequence:
MAGVVRLTTTSVQAIRVSSSFSSFATALNPLQPCLPPNSNLNSDKRLRLLSSSPSCSSSHYHPSSGLGSHLPLRRPKSQVVRVKVDENVAETEPPKWWERNAPNMVDIHSTEEFLSALSGAGERLVIVEFYGTWCASCRALFPKLCKTAVEHPDIVFLKVNFDENKPMCKSLNVRVLPFFHFYRGADGQLESFSCSLAKVKKAISVSPFPQLELGITLQTKRTTSLFFFDRIYQIL
Protein: RING/U-box superfamily protein (Q8GXD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMSELDLGTSQRMTETHRTTTTFLDLLRRQMSGHDLTRRKRTLKERLRFKCIGCCGPTWNLRLTNNTTLHSPTSRDDEIEELQIETGLVLESDHGSGTGMNLATALEAERYNRGESTEAEADMTPRRVSLMRLLEETAEKIVDDDGKETEILTASIGTLTGNDSVCCVCMGRKKGAAFIPCGHTFCRVCSRELWLNRGSCPLCNRPIIEILDIF
Protein: Uncharacterized protein, isoform C (A0A0B4KFJ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRTEAAVSCFLLVLHRVCCQSGNDESWLSPDPAWSDLVNDINQPGELCQCPTCPDVSPVAMEDAVALTYFKKFVNLLFQRKRFQRSLLFSLIPSQLDELERVQDARDLDVLLTKILESAEEAPLFNGRSGCSYVRHGFFSLLVDIFKDVIELTQTTEVKFILYATLAIALVVIVHKRFRVGLISIVLGGVFLCGYIQTYLECNRELDIDRMIEVVNHHHEPESSWFGRLLGYIYQASPKTKKIEMIKKSAKISISICMPDQVFFMYMNNIFIKQLEIMIEKVSVTMTKLSSGLSFPYNLLAPVLLVFLVGYTIKLCFKYILSPRAWASLLHKPAPQGTPTIHQSINARAPEGDSISGDNLKMLLNVINVRNVPKESLQRIPDVSGVQELEEKQEAPTTPSKKENLDESDSSSKSKSKSCVAEDEGFTLVDDHEDNNIDNV
Protein: SWR1 complex subunit vps71 (O59669)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- SWR complex protein 2
- RuvB-like helicase 1
- Actin-like protein arp6
- Helicase swr1
- RuvB-like helicase 2
- SWR1-complex protein 5
- Protein AF-9 homolog
- Histone H2A.Z
- SWR1-complex protein 4
- Actin-related protein 4
Sequence:
MFVTPIEHAVQKRKKQKQRSVVDPVTRERQLKRNLADLEKDNFSDIRFEIPKDLLQRRVLPISVRRILSSRKTFVNYLDETPNSRYNTCVAKPSYKPPRKFCNVCGYWGKYACQNCGTSYCSKGCEVIHSETRCMKVYA
Protein: Sad1 and UNC84 domain containing 1 (A0A8I6ALL7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus inner membrane {ECO:0000256|ARBA:ARBA00004540}.
Interaction partners:
Sequence:
MDFSRLHTYTPPQCVPENTGYTYALSSSYSSDALDFETEHRLEPVFDSPRMSRRSLRLITTTAAYSSGDGQTVDTHISTSRATPAKGRETRTVKQRSASKPAFSINHLSGKGLSSSTSHDSSCSLRSATVLRHPVLDESLIREQTKVDHFWGLDDDGDLKGGNKAATQGNGELAAEVASSNGYTCRDCRMLSARTDALTAHSAVHGPTSRVYSRDRTLRPRGASFYLDRTLWLAKYTSSSFASFIVQLFQVVLMKLNFESETYKLKGYESRAYESQSYETKSHESEAHLGHCGRMTAGELSRVDGESLCDLLVRALRRTRAAGWSVAEAMWSVLWLAVTAPGKAASGTFWWLGSGWYQFVTLISWLNVFLLTRCLRNICKVFVLLLPLLLLLGAGFSLWGQGNFFSLLPMLNWTAMQPAQRVDNPKDMHRPGPLSPSPPLKVDPMASQWPQESDMGQKIASLSAQCHNHDERLAELTVLLQKLQIRVDQVDDGREGLSLWVKDMVGQHLQEIGSIEPPDAKTDFLTLHHDHEVRLSSLEDVLRKLTEKSEAIQKELEETKLRAGSRDEEQPLLDRVQHLELELNLLKSQLSDWQHLRSSCEQADARIQETVQLMFSEDQPGGSLEWLLQKLSSRFVSKDELQVLLHDLELKLLQNITHHITVTGQAPTSEAIVSAMSQAGISGITEAQAHIIVNNALRLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALLSLFGVPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLSPTGNISSAPRDFAVYGLETEYQEEGQPLGRFTYDQEGDSLQMFHTLERPDQGFQIVELRVLSNWGHPEYTCLYRFRVHGEPIQ
Protein: Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) (Q60700)
Organism: Mus musculus (Mouse)
Function: Protein kinase which is part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.
Subcellular location: Cytoplasm. Cell membrane {ECO:0000269|PubMed:8663324}. Note=Behaves essentially as an integral membrane protein. {ECO:0000269|PubMed:8663324}.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase 7
- C-Jun-amino-terminal kinase-interacting protein 1
Sequence:
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANSVLQLHEQDTGGPGGATGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPGGLGVGPSAWDACPPALRGLHHDLLLRKMSSSSPDLLSAALGARGRGATGGARDPGSPPPPQGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTAGRGGNRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELPPSQRWPQGPNMRQSLSTFSSENPSDVEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPEREASSLPMQHQDGQGPNPEDSDCDSTELDNSNSIDALRPPASLPP
Protein: Lupanine 17-hydroxylase [cytochrome c] (EC 1.17.2.2) (Quinohemoprotein lupanine hydroxylase) (Q934G0)
Organism: Pseudomonas sp
Function: Catalyzes the first reaction in the catabolism of the alkaloid lupanine. It dehydrogenates lupanine, which can then be hydrated to produce 17-hydroxylupanine.
Subcellular location: Periplasm {ECO:0000269|PubMed:12686118}.
Interaction partners:
Sequence:
MSANKNIWIIRLGVAFVCVAIGAAQANEKDGSAVTSGNWSLLGGGNEQHYFSALKDVNKSNVKNLGLSWFTDMEAGDGLVGNPLVADGVIYQGGPPGKIYANDLKTGKNLWTYTPEVQYDKDTSWTGFWGTHVNRGLAVDDDNVYIGSYCKLLAVSRTTHKLTWSSQSCDPKKMQAITGAPRVGGGKVFIGNASGDFGGDRGHLDAFDAKTGKHLWRFYTMPGDPSKPFENDLLAKASKTWGTDYWKYTKGGVSPWDAITYDEASDTLYFGTDGPSPWSPAQRAPDAGDELFSHSIIAVDASTGAYKWHFQTVQNDGSNMSATMHIMLADLPVEGVSKRVVMTAPKNGYFYVLDASTGKFISADHYVPVNWTKGLDPKTGRPIPSNEANYWERPGEMTIPLPGDVGGHNWEAMAYNPELRTVYIPSTLVPVTVVASKDTGELDLDYYYGMRPDATIKTQGDLVAWDPLLQKEKWRAKRSLPVNGGVLATAGGLVFQGTGDGHFEAFDANTGEKLWSFHVGGSILAAPTTVEVDGDQYLIVASGNGGASGMRGIPRLMNNLQSQGPARLLAFRLGGKTELPITSTPDFPKPQYPKPTSAMAESGRHIFNANACGACHGFNAEGSTPGLPDLRRSDKLDLAVMKSIVIDGAFKPLGMPGHPHISDADLQALQAFILQKAWTAYDTQQTLKTSDTGAQ
Protein: Hxt5p (A0A1D8PSH1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Hgt12p
Sequence:
MSSVSSENNSGLFGTDVYDETKENKPKYEHEEGLEFGSDFDFDGEFEKYAAMGAAEKQSGAWMTNFKNLEFPLGVSPSVLVQTLGIFAAFCGILSGVDQSLISGASIGMDKSLHFNSHENSLVSSLMPLGAVAGSILLTPLQRFGRKKALMASCILYTIGAILCAAAPIPKELADGTFNNHRSRDVMYAGRFILGIGVGIEGGGVGVYISESVPSNKRGSLVSLYQLSIALGEVLGYAIAAIFYEVHGGWRFMVGSSLVFSTIVLIGLFFLPESPRYLVFKGKFGEAFNVFARLRDLGDRHSKIEFVQMVQAAEAERELRLTQNKSKVWFELVTIPRNRRALVYGIVMITLGQLTGINAVMYYLSTLMGRIGFSTKNSVFMSLVGGGSLLIGTIPAILYMDKFGRRVWGYNLVGFFVGLVLVGVGYSIDIETNLAAAEGVYLTGLILYMGFFGSYACLTWVVPAESFSLGTRSQGMTICSALLYLWAFTVTYNFNRMKVAMTYTGLTIGFYGGIAFLGFFYQVLFMPETKGKTLEEIDEIFEKPSRQLIKENLSGLKRFWGR
Protein: Glucan 1,3-beta-glucosidase (EC 3.2.1.58) (Exo-1,3-beta-glucanase) (O13990)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.
Subcellular location: Secreted, cell wall {ECO:0000250}. Note=Tightly bound to cell wall. {ECO:0000250}.
Interaction partners:
- Glucan 1,3-beta-glucosidase 1
- Putative beta-glucosidase
- 1,3-beta-glucan synthase component bgs4
- Invertase
- 1,3-beta-glucan synthase component bgs1
- Glucan 1,3-beta-glucosidase 2
- Alpha-glucosidase
- Uncharacterized family 31 glucosidase C30D11.01c
- Uncharacterized family 31 glucosidase C1039.11c
- 1,3-beta-glucan synthase component bgs3
Sequence:
MQFLSSFVFAALALLPLSAMAVDEAASEIASSTKPASTNGTLSFCLGVKHADGTCKYTDDYLADFEVLAPYTNMIRTYATSDCNTLEYLLPALAQSPYNFSAILGVWPTDDAHYDLEKQALMQYLPQYGVDHVRAITVGSEVLYRNDLPADVLAERIYDVRGLVQQKLGFDVPVGTADSWNLWAGGSGDVVITASDFIMSNDFPYWQGQNTSNMTNTFISDTLAALERVQSVKGTNNVTFWVGETGWPTDGPSYGEADATVDIASEFFQEALCNIRRKGIDIFFFEAFDEDWKGDSSSVEPYFGAMYSNRTLKYNLNCTSE