wanglab/gogpt-training-data huggingface dataset:
Protein: Energy-coupling factor transporter ATP-binding protein EcfA1 (ECF transporter A component EcfA1) (EC 7.-.-.-) (Q71WH7)
Organism: Listeria monocytogenes serotype 4b (strain F2365)
Function: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01710}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01710}.
Interaction partners:
Sequence:
MAESFVRLEHVFYKYEDTEKYAVKDVSISAQKGEWVALVGHNGSGKSTIAKLLNGLLFPEDGLIKIGHFVLSEKNIWDIRRQVGMVFQNPDNQFVGATVQDDVAFGLENHGVPHDTMVERVESALNEVGMQSYALHEPARLSGGQKQRVAIAGVLALQPDVIILDEATSMLDPRGRAEVMETIRIMREQEDITVISITHDLDEVLFADRVIVMNNGEVHSEGTPQEIFEQADAMREIGLGVPFIIELQEKLVAGGFETGSTVLSEGALLDQLWKLNSNN
Protein: Myeloid differentiation primary response protein MyD88 (Q6Y1S1)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q99836}. Nucleus {ECO:0000250|UniProtKB:Q99836}.
Interaction partners:
- Interleukin-1 receptor-associated kinase 4
- Interleukin-1 receptor-associated kinase 1
- Toll-like receptor 4
- Interleukin-1 receptor-associated kinase-like 2
- TNF receptor-associated factor 6
- Toll-like receptor 7
- Mitogen-activated protein kinase kinase kinase 7
- Toll-like receptor 9
- Toll-like receptor 2
- Toll/interleukin-1 receptor domain-containing adapter protein
Sequence:
MSAGGPRVGSVSVDSYLFSLPLVALNVGVRRRLSLFLNPRTTAAADWTSLAEEMGFEYLEIREFETRPDPTRSLLDAWQGRSGSSVGRLLELLALLDREDILYELKDRIEEDCQKYIRNQQKQESEKPLQVARVESSVPQTKELGGITTLDDPLGQTPELFDAFICYCPSDIEFVQEMIRQLEQTDYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGVQQKRLIPIKYKAMKKDFPSILRFITICDYTNPCTKSWFWTRLAKALSLP
Protein: Integrin beta (B2RYB8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}. Membrane raft {ECO:0000256|ARBA:ARBA00035630}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00035630}.
Interaction partners:
- Integrin subunit alpha L
- Integrin alpha-D
- Intercellular adhesion molecule 1
- Integrin subunit alpha X
- Intercellular adhesion molecule 2
- Talin 2
- Vascular cell adhesion protein 1
- Talin 1
- Integrin alpha-4
- Integrin subunit alpha 5
Sequence:
MLGPHTLLLILAGLLFLGSALSEECTKYKVSNCRDCIQSGPGCSWCQKLNFTGPGEPDSLRCDTRAQLLLKGCPADDIMDPKSFADLHPQYQVQRSQLSPQKVTLNLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLNNVKKLGGDLLQALNEITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKACQPPFAFRHVLKLTDNSNQFQTEVGKQLISGNLDAPEGGLDAIMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNMYKRSNEFDYPSVGQLAHKLSESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSDDSSNVVQLIKKAYYKLSSRVFLDHTTIPDTLKVTYDSFCNNRVSSIGKSRGDCDGVQINNPVTFQVKVTASECIQEQSFVIRALGFTDTVTVQVHPQCECQCRDQSRMRNLCGGKGVMECGICRCESGYIGKNCECQTQGRSSQELEGNCRKDNSSIVCSGLGDCICGQCVCHTSDIPNKVIFGQYCECDNFNCERYDGQVCGGLKRGSCSCGQCNCKEGFEGSACQCQRSTTGCLNARLVECSGRGRCQCNRCICEKGYQPPLCEECPGCPLPCSTYVFCAECLKFDKGPFQKNCSVQCANVTLQTVPFKKKPCKERDSEGCWITYTLQQKDGNAYNIHVDDDRECVKGPNVAAIIGGTVAGVVLIGVLLLVIWKALTHLTDLNEYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
Protein: S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Q91X83)
Organism: Mus musculus (Mouse)
Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Interaction partners:
- Methionine adenosyltransferase 2 subunit beta
- Betaine--homocysteine S-methyltransferase 1
- S-adenosylmethionine synthase isoform type-2
- Methionine synthase
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
- S-adenosylmethionine decarboxylase proenzyme 1
- S-adenosylmethionine decarboxylase proenzyme 2
- Tyrosine aminotransferase
- DNA
- DNA
Sequence:
MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
Protein: Ras-related protein Rab-4A (EC 3.6.5.2) (P20338)
Organism: Homo sapiens (Human)
Function: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
Subcellular location: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:1425574}. Cytoplasm {ECO:0000269|PubMed:1425574}. Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. {ECO:0000269|PubMed:1425574}.
Interaction partners:
- Rabenosyn-5
- Rab GTPase-binding effector protein 1
- RUN and FYVE domain-containing protein 1
- Rab11 family-interacting protein 1
- Ras-related protein Rab-5A
- TBC1 domain family member 16
- Early endosome antigen 1
- A-kinase anchor protein 10, mitochondrial
- Rab5 GDP/GTP exchange factor
- Rab GDP dissociation inhibitor alpha
Sequence:
MSQTAMSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFVQCARKILNKIESGELDPERMGSGIQYGDAALRQLRSPRRAQAPNAQECGC
Protein: Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) (Q9BXK1)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Paired amphipathic helix protein Sin3a
Sequence:
MSAAVACVDYFAADVLMAISSGAVVHRGRPGPEGAGPAAGLDVRAARREAASPGTPGPPPPPPAASGPGPGAAAAPHLLAASILADLRGGPGAAPGGASPASSSSAASSPSSGRAPGAAPSAAAKSHRCPFPDCAKAYYKSSHLKSHLRTHTGERPFACDWQGCDKKFARSDELARHHRTHTGEKRFSCPLCSKRFTRSDHLAKHARRHPGFHPDLLRRPGARSTSPSDSLPCSLAGSPAPSPAPSPAPAGL
Protein: Uncharacterized protein (A1ZBV0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO04221p1
- GEO09613p1
- Uncharacterized protein, isoform A
- LD15563p
- Brother of bearded A
- Scavenger receptor class C, type II, isoform A
Sequence:
MKFVAILLLSSLTIAMVLAFPDNDDKNVLVPADMQHVAPLAAAADPPTSADQVSNSIRGPRHLLSKLFQPKTVVVQPVIVEQVAPRQYPGYAQPYPYYNQGRRYW
Protein: Histocompatibility 13 isoform 1 (A0A0S2Z5V7)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|ARBA:ARBA00004366}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004366}; Lumenal side {ECO:0000256|ARBA:ARBA00004366}.
Interaction partners:
Sequence:
MDSALSDPHNGSAEAGGPTNSTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSVRCARGKNASDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSHTISPFMNKFFPASFPNRQYQLLFTQGSGENKEEIINYEFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGEVTEMFSYEESNPKDPAAVTESKEGTEASASKGLEKKEK
Protein: High mobility group nucleosome binding domain 1 (A6NL93)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPKRKVSSAEGAAKEEKPPAKVEAKPKKAAAKDKSSDKKVQTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD
Protein: Dof zinc finger protein DOF5.4 (AtDOF5.4) (OBF-binding protein 4) (Q8LDR0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence. Enhances the DNA binding of OBF transcription factors to OCS elements (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein AUXIN SIGNALING F-BOX 3
- Transcription factor RSL2
- Transcription factor TGA4
- Xyloglucan endotransglucosylase/hydrolase protein 9
Sequence:
MQDIHDFSMNGVGGGGGGGGRFFGGGIGGGGGGDRRMRAHQNNILNHHQSLKCPRCNSLNTKFCYYNNYNLSQPRHFCKNCRRYWTKGGVLRNVPVGGGCRKAKRSKTKQVPSSSSADKPTTTQDDHHVEEKSSTGSHSSSESSSLTASNSTTVAAVSVTAAAEVASSVIPGFDMPNMKIYGNGIEWSTLLGQGSSAGGVFSEIGGFPAVSAIETTPFGFGGKFVNQDDHLKLEGETVQQQQFGDRTAQVEFQGRSSDPNMGFEPLDWGSGGGDQTLFDLTSTVDHAYWSQSQWTSSDQDQSGLYLP
Protein: Glucosamine-6-phosphate deaminase (EC 3.5.99.6) (GlcN6P deaminase) (GNPDA) (Glucosamine-6-phosphate isomerase) (Q8DV70)
Organism: Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
Interaction partners:
- N-acetylglucosamine-6-phosphate deacetylase
- Glutamine--fructose-6-phosphate aminotransferase
- Glucose-6-phosphate isomerase
- Mannose-6-phosphate isomerase
- Phosphoglucosamine mutase
- Fructokinase
Sequence:
MKTIKVKNKTEGSKVAFRMLEEEITFGAKTLGLATGSTPLELYKEIRESHLDFSDMVSINLDEYVGLSADDKQSYAYFMKQNLFAAKPFKKSYLPNGLAADLAKETEYYDQILAQYPIDLQILGIGRNAHIGFNEPGTAFSSQTHLVDLTPSTIAANSRFFEKAEDVPKQAISMGLASIMSAKMILLMAFGEEKAEAVAAMVKGPVTEEIPASILQTHPKVILIVDEKAGAGI
Protein: Arginine N-methyltransferase, putative (EC 2.1.1.-) (Q4GYA9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Arginine N-methyltransferase, putative
- Metallo-beta-lactamase domain-containing protein
- Small ribosomal subunit protein uS5
- Disulfide isomerase, putative
Sequence:
MTVDANAASSTTTTTDYYFDSYSHYGIHMEMLKDCHRTTSYRDAMWRNAYLFKDKVVLDVGCGTGILSMFAAKAGARKVIGVDCSTVAVQAREIVRDNGFEDVITIIQGKVEEIQLDEKVDIIISEWMGYFLLYESMLNTVLYARDNLGTPDVKMFPDKANMHVCGITDEQYIQERFNIWDNVQGIDFSYFKRLSFIEPLVDTVERSQIVTNVAPLVSFDINTVKEADLSFTSEFALEAQASRGKRNGGNSIIYVHALSVHFDTPFTAGHEVVILDTTPYSPPTHWRQTVLYLFNPLRMRAGERATFRMKCSPNALNGRDLDISLHVDFEGALQISHYDQDFRLR
Protein: Mevalonate kinase (MK) (EC 2.7.1.36) (Q86AG7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid biosynthesis.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Diphosphomevalonate decarboxylase
- phosphomevalonate kinase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
- Probable acetyl-CoA acetyltransferase
- GMP synthase
- Farnesyl diphosphate synthase
- hydroxymethylglutaryl-CoA lyase
- Acetyl-CoA C-acyltransferase
- 2-Hydroxyacid oxidase
Sequence:
MISNQDNIIQVSAPGKIILFGEHAVVLEKTAIASALSLRTTVTFTPNTNNTLLLDFPDLAGFGVREWSLDEFKKLDHFPNDIDILKPIECSELFQQELNKIIDIKGIHTFLFLFCALTKCTKAYNIKITSDLPIGAGLGSSASFCVSICAGLLKAFDTYICGGCKQCIGGQGQQQQICNEQLNLINLWSLQGEKIMHGTPSGIDNAVATFGKALTFTRKNGYKILENGIPPLRILITNTRVSRSTKTLVEGVIQRSKLYPTLIDPVSNLIDTISSQCIESFNQYHTDKDYEKLQQTMDLMFDMNQHLLSGCYGVGHSSIDTIVSITKSLGFHTKLTGAGGGGCVITLLKQDTTIDQLSNLKLTLSSNGFESWEATIGDPGVSINILPIQK
Protein: F-box/kelch-repeat protein At1g51550 (Q9C8K7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- UPF0235 protein At5g63440
- Protein RETICULATA, chloroplastic
- At1g19540
- Probable inactive receptor kinase At4g23740
- Cysteine-rich repeat secretory protein 18
- V-type proton ATPase subunit c3
- Phosphatidylinositol/phosphatidylcholine transfer protein SFH6
- Putative clathrin assembly protein At2g01600
- At1g48690
- Probable cysteine protease RD21C
Sequence:
MAAESTRNSSPPSTSQSSSPIINLPDDHLLTILLLLPVDSILSFSMTCKRYKSLACSDSLWEALCEREWGPTSVDALKLSSLRDGFSWMLMFQRVYKMDSVCCHKISDPDDDDEESSSFPIPRASHSLNFVNDHLVLFGGGCQGGRHLDDTWTSYVDKSNQSILKWKKVKSGTPSGRFGHTCIVIGEYLLLFGGINDRGERLNDTWIGQVFCHEGLSWKLLNVGSLQRPRPPPRGAHSACCIAEKKMVVHGGIGLNGVRLGDTWILELSEDFSSGTWHMVESPQLPPPRSGHTLTCIRENQVVLFGGRGLGYDVLDDVWILDIQEPCEEKWIQIFYDFQDVPEYASLPRVGHSATLVLGGRILIYGGEDSYRHRKDDFWVLDVKTIPSSGLKPQGLSLNGSSVWKKLDRISYGPKSRSFHRACADCSGRFLYVFGGMVDGLLQPAASSGLRFDGELFMVELVLGFSDLDHQQRPGKSM
Protein: Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase) (Invertebrate-type lysozyme) (P86383)
Organism: Meretrix lusoria (Hard clam) (Common Orient clam)
Function: Has bacteriolytic activity against Gram-positive bacteria M.luteus. Also has chitinase activity.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P83673}.
Interaction partners:
Sequence:
FAGGIVSQRCLSCICKMESGCRNVGCKMDMGSLSCGYFQIKEAYWIDCGRPGSSWKSCAASSYCASLCVQNYMKRYAKWAGCPLRCEGFAREHNGGPRGCKKGSTIGYWNRLQKISGCHGVQ
Protein: Serrate RNA effector molecule homolog (Arsenite-resistance protein 2 homolog) (Q5TUF1)
Organism: Anopheles gambiae (African malaria mosquito)
Function: Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Nuclear cap-binding protein subunit 2
- Nuclear cap-binding protein subunit 1
- AGAP006733-PA
- Phosphorylated adapter RNA export protein
- RNA helicase
- RNA helicase
- AGAP007874-PA
- Serine/arginine repetitive matrix protein 1
- Peptidyl-prolyl cis-trans isomerase
- peptidylprolyl isomerase
Sequence:
MGDSDDEYDRKRRDKFRGERSAGGGGDSYGRGADRPDRSRGRDDWPDRVRPRQDYRDYRPPPRDRGYSPAREGPTVKRMRGDTWGDEGRHRFGAHDGYGMYGYAHDHFGMHPTVGPYGHQHATHQREPVVSGDMQTQPCMMTLKQFLATQDDSISDSDAITKYNEYKLEFRRQQMNEFFVAHKDEEWFKIKYHPEESQKRKEEQLSFLKRRCEVFLELLKSKEIGKVSVDASNTDALLRLLDTVVIKLEGGTEEDLKVLDIKPSVVEAAARTPATLNEEKVKTESKVDATAKELAVKMEEDSSKQETETDVLSVPQSEEDARNGNSKIKEELSKSMDDGNENGDKSKSNDAQKSEKEIAEVEHEAHKHESEDRKKRSRSDSGSSSSSSSSSSSSESEEEKDERMNKEDNEDEENMRIPEEEKKSDSADTMDNINRDKEVDEGKPVCDAEDLNTADDRDDNADQNKEQNEFEETTKDKNSSDPVNDENKENSDKKSQQEGDSKAETIDLAKDPADGGSRALHRTSSIFLRNLAPSITKAEVEAMCRRYNGFLRVAIADPLLERRWFRRGWVTFKREVNIKEICWNLNNIRLRDCELGAIVNKDLSRRVRPVNGITCHKTVVRSDIKLGAKIAHNLDDKWGLWKETPTAASGTGEAGDKNGSEVQPEESFGLQSKNPVLQNITDYLIEEASAEEEELLGLSEDSKKVSEGELIERDPQLIEVLDRLILYLRIVHSVDFYNHCEYPYEDEMPNRCGIIHARGPPSQSKVMSNEIQEYIRTFEGKMASFLTRMVDIDETDMKKLGAKDAEAEVEKFITANTQELAKDKWLCPLSGKKFKGPDFVRKHIFNKHAEKVEEVRKEVEYFNNYLKDSKRPQLPEHPGNAKKPGSEGATSATANASVGAGGYRNQPFGMSHSYAPMYASYAAASMMAPNPRGRAGFGRGGRMGGPDYRPVIHYRDLDAPREPDEFL
Protein: Hepcidin-2 (Q7T273)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Liver-expressed antimicrobial peptide 2
Sequence:
MKLSNVFLAAVVILTCVCVFQITAVPFIQQVQDEHHVESEELQENQHLTEAEHRLTDPLVLFRTKRQSHLSLCRFCCKCCRNKGCGYCCKF
Protein: Annexin-2 receptor (Annexin II receptor) (AXIIR) (Q3ZCQ2)
Organism: Homo sapiens (Human)
Function: May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.
Interaction partners:
- Annexin A2
- Protein S100-A10
Sequence:
MEQHFLGCVKRAWDSAEVAPEPQPPPIVSSEDRGPWPLPLYPVLGEYSLDSCDLGLLSSPCWRLPGVYWQNGLSPGVQSTLEPSTAKPTEFSWPGTQKQQEAPVEEVGQAEEPDRLRLQQLPWSSPLHPWDRQQDTEVCDSGCLLERRHPPALQPWRHLPGFSDCLEWILRVGFAAFSVLWACCSRICGAKQP
Protein: DNA mismatch endonuclease Vsr (EC 3.1.-.-) (Type II nicking enzyme) (V.EcoKDcm) (Very short patch repair protein) (Vsr mismatch endonuclease) (P09184)
Organism: Escherichia coli (strain K12)
Function: Deamination of 5-methylcytosine in DNA results in T/G mismatches. If unrepaired, these mismatches can lead to C-to-T transition mutations. The very short patch (VSP) repair process in E.coli counteracts the mutagenic process by repairing the mismatches in favor of the G-containing strand. This enzyme is an endonuclease that nicks double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the thymidine residue that is mismatched to 2'-deoxyguanosine. The incision is mismatch-dependent and strand-specific.
Interaction partners:
- DNA-cytosine methyltransferase
- DNA mismatch repair protein MutL
- DNA mismatch repair protein MutH
Sequence:
MADVHDKATRSKNMRAIATRDTAIEKRLASLLTGQGLAFRVQDASLPGRPDFVVDEYRCVIFTHGCFWHHHHCYLFKVPATRTEFWLEKIGKNVERDRRDISRLQELGWRVLIVWECALRGREKLTDEALTERLEEWICGEGASAQIDTQGIHLLA
Protein: PANX2 protein (Q495U3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF
Protein: Ankyrin-repeat and fibronectin type III domain containing 1 (A0A140LIW7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XNYCSKMTQQMQNLHLSQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFDEAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDLDAVQLLLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSLESRAMHLNTLVQEAQDRVSELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEVPANACLMVSSSTSLTVSFQEPLSVNAAVVTRYKVEWSMSKDFSPLAGEIIMDNLQTLRCTITGLTTGQQYFVQVSAYNMKGWGPAQTTTPVCASPSNWKDYDDREPRHKGQSEVLESLLQQVRALHQHYSCRESSKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIATIFYYKDNMLVTNEDQIPIVEIDDSHTSSITQDFLWFMKLSCMWEDIRWLRQSVPISMSSSTVLQTRQKMLAATAQLQNLLGTHNLGRLYYEPIKDRHGNILIVTIREVEMLYSFFNGKWMQISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLSPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENHNISKEEWEWIQKLSGSESMESVDHNADCPMQLFFYELQMAVAALLKQINIPRHQARNFRLYTQEVLEIGHNVSFLLLLPASDDVCTAPGQNNPYTPHSGFLNLPLQMFELVHFCSYREKFISLYCRLSAVVELDSLNTQQSLREAISDSEVAAAKQRHQQVLDFIQQIDEVWREMRWIMDALQYARYKQPVSGLPITKLIDSSSEQNLKKISSTSSHIDCLPSTSPSPEMHRRKAVSESQPCSDEEGCSEVFLPTDSDYDSSDALSPRDLDLVYLSSHDIAQQALSGLSGSAPDVLQVHDMKASMGPGQDPQGPGQGPDTDHSCVEFLHSLTLTGLAPKNHAKMVAGTRPPLGFLGKRKPGKHQHYGGFSRHHRWLRMHSETQSLSLSEGVYTQHLSQACGLAEDPGEAEGPGPVVDGPRGLPLAHAASLPEERRSCLQDPRRPLQRVYVEPYSDTLAGQDPKLWTSLSPTPAGRSSLPSSTSSEMSPDPTSPVSEILSSML
Protein: Plant invertase/pectin methylesterase inhibitor superfamily protein (F4JCN4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MQQSFTFQLLPVDFFSPKITDSSSSNFLRSKNHYPSMESINTLKGYDKVSDQENQIHHHHHSPLPKPSSFSRKTLIATGSVVSLLLILSVVALTAGAFTHSPPHHPPISSASLKSLCSVTRYPETCFNSLSSSLNESDSKLNPESILELSLRVAAKEISNLSISFRSINDMPEDAAVGDCVKLYTDALSQLNDSITEIERKKKKGGNNWLTEEVVGDVKTWISAAMTDGETCSDGIEEMGTIVGNEIKKKMEMANQMMSISLAIVSQMKKLLLIFH
Protein: Small integral membrane protein 14 (Q96QK8)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24499674}; Single-pass membrane protein {ECO:0000269|PubMed:24499674}.
Interaction partners:
Sequence:
MAEGGFDPCECVCSHEHAMRRLINLLRQSQSYCTDTECLQELPGPSGDNGISVTMILVAWMVIALILFLLRPPNLRGSSLPGKPTSPHNGQDPPAPPVD
Protein: Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60) (Q3U2J5)
Organism: Mus musculus (Mouse)
Function: Catalyzes the trimethylation of 'Lys-116' in calmodulin.
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q7Z624}. Nucleus {ECO:0000250|UniProtKB:Q7Z624}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus {ECO:0000250|UniProtKB:Q7Z624}.
Interaction partners:
- Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
- Calmodulin-1
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Prolyl endopeptidase-like
- Histidine protein methyltransferase 1 homolog
- Methyltransferase-like protein 22
- N-lysine methyltransferase KMT5A
- Histone-lysine N-methyltransferase EHMT2
Sequence:
MESQVAAAGAAETEAEAGKRPAMGSASQGSLVSAPKGAVRWQLLRQVLKQKQLDDHLRHVSVRRFESFNLFSVTEATKKGTEKEAGVWVQYTSIFYPKYSISVRHNSGSLNVEDVLTSFDNTGNVCIWPSEEVLAHYCLKHSHIFRDLAVCELGGGMTCLAGLMVAISADVKEVLLTDGNEKAIRNVDSIIACNKKTGVFKTPKISSRVLRWDNETDVSQLEGHFDIVMCADCLFLDQYRASLVDAIKRLLQPTGKAVVFAPRRGNTFNQFCNLAEKAGFSLQRHENYDEPISNFHSKLKKEGSDIYEENLHYPLLLILTKTG
Protein: Glycine betaine/carnitine transport binding protein GbuC (Q9RR44)
Organism: Listeria monocytogenes serotype 1/2a (strain 10403S)
Function: Part of the ABC transporter complex GbuABC involved in glycine betaine uptake. Involved, with BetL and OpuC, in osmoprotection and cryoprotection of Listeria. Can also uptake carnitine when carnitine is abundant in the growth medium.
Subcellular location: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
Sequence:
MLKKLITTAVLAMLIFTLAACGTTLAPYDAKKDLGEQINYTITGIDAGAGIMLATQNAIKDYHLDDDNWQLQTSSTAAMTSTLQKAMKDKRPIVVTGWTPHWMFTKFDLKFLDDPKNVYGNAENIHTIVRKGLKEDKPSAYQVLDNFFWTAEDMSEVMLEVNDGVDPEEAAKKWIKNNPDKVAKWTDGVEKVDGDEIKLTYVAWDSEIASTNVVAEALKQVGYKPTIQAMEIQPMWASVATDAADGMVAAWLPNTSGIYYKDYKGKFEDLGPNLKGAKIGLAVPKYMTNINSIEDLKTSK
Protein: Necdin isoform A (Necdin-like protein isoform 1) (X5D982)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSEQSKDLSDPNFAAEAPNSEVHSSPGVSEGVPPSATLAEPQSPPLGPTAAPQAAPPPQAPNDEGDPKALQQAAEEGRAHQAPSAAQPGPAPPAPAQLVQKAHELMWYVLVKDQKKMIIWFPDMVKDVIGSYKKWCRSILRRTSLILARVFGLHLRLTSLHTMEFALVKALEPEELDRVALSNRMPMTGLLLMILSLIYVKGRGARESAVWNVLRILGLRPWKKHSTFGDVRKLITEEFVQMNYLKYQRVPYVEPPEYEFFWGSRASREITKMQIMEFLARVFKKDPQAWPSRYREALEEARALREANPTAHYPRSSVSED
Protein: PIH1D1/2/3 CS-like domain-containing protein (Q580K1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Regulator of nonsense transcripts 1, putative
- Telomerase reverse transcriptase
- RRM domain-containing protein
- Nuclear cap-binding protein subunit 2
Sequence:
MSYSDIQSLAQLLDRNHGFKRPDGQSVGYSLQETAPTAVVNHGDSAAAPNPSNIPLPATVIDQQLCLPIPSESREAKRIQAKQHQARRPKGYAIWTDDELNEVHQFRKDTTTKPRDGVEEPEYTILHQEKVTAEDLYLGMDFTRTGSSGLLVKVTMPKQARIADVAIEVDPYEFRLSSTKYFLRAALPQKVFAGKAYVRWNVENKTLEACLYVDDSDRLV