wanglab/gogpt-training-data huggingface dataset:
Protein: Cationic amino acid transporter 1 (Amino acid transporter 1) (Q84MA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High-affinity permease involved in the transport of the cationic amino acids (e.g. arginine, lysine, histidine, citrulline, valine, and glutamate). Transport mostly basic amino acids, and, to a lower extent neutral and acidic amino acids. May function as a proton symporter.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable sugar phosphate/phosphate translocator At3g17430
- RNA polymerase I specific transcription initiation factor RRN3 protein
- Glycosyltransferase family protein 2
- RNA polymerase I specific transcription initiation factor RRN3 protein
- WAT1-related protein At1g70260
- AT5g12260/MXC9_22
- RNA polymerase I specific transcription initiation factor RRN3 family protein
- ECA1 gametogenesis family protein
Sequence:
MASGGGDDGLRRRGCSCTKDDFLPEESFQSMGNYLKALKETPSRFMDRIMTRSLDSDEINEMKARSGHEMKKTLTWWDLMWFGIGAVIGSGIFVLTGLEARNHSGPAVVLSYVVSGVSAMLSVFCYTEFAVEIPVAGGSFAYLRVELGDFMAFIAAGNIILEYVVGGAAVARSWTSYFATLLNHKPEDFRIIVHKLGEDYSHLDPIAVGVCAIICVLAVVGTKGSSRFNYIASIIHMVVILFVIIAGFTKADVKNYSDFTPYGVRGVFKSAAVLFFAYIGFDAVSTMAEETKNPGRDIPIGLVGSMVVTTVCYCLMAVTLCLMQPYQQIDPDAPFSVAFSAVGWDWAKYIVAFGALKGMTTVLLVGAIGQARYMTHIARAHMMPPWLAQVNAKTGTPINATVVMLAATALIAFFTKLKILADLLSVSTLFIFMFVAVALLVRRYYVTGETSTRDRNKFLVFLGLILASSTATAVYWALEEEGWIGYCITVPIWFLSTVAMKFLVPQARAPKIWGVPLVPWLPSASIAINIFLLGSIDTKSFVRFAIWTGILLIYYVLFGLHATYDTAKATLKEKQALQKAEEGGVVADNSCSAT
Protein: Calcium-binding protein 4a (Q54RF4)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Nucleomorphin
- Probable serine/threonine-protein kinase roco11
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase qkgA
- Probable serine/threonine-protein kinase roco8
- Protein BUD31 homolog
Sequence:
MVTKKEFLEDLTNATNEMIKAGDKNGDNQLSKKELYELFKKCKYPNPTLVTNSLLELFDLDKDGKLSVNEVKTALLVDYIIEAETCLKKFVDSIFKADSNKDNKITWDEARQFFVTSGSNEAQAKVFANSMFEDVDSDDDKCITREELREYAIEYYEIYPTE
Protein: Endoribonuclease Arlr (EC 3.1.-.-) (EC 4.6.1.-) (Poly(U)-specific endoribonuclease homolog) (Protein Age-related lipid regulator) (Q9VZ49)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes RNA cleavage releasing a product with a 2',3'-cyclic phosphate at the 3'-end.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:37803019}. Secreted {ECO:0000305}.
Interaction partners:
- Lipid scramblase CLPTM1L
Sequence:
MRCLALSAVFLCLTLAGHFHLSDAYKNEVQITPDPLDAVETTTKKSSWFGGFKKFFGSDGTTTTTSTIAPPVVTSPKSVVVTPTAANKPPPLVISHAPLMPLGPRPDTPGSSPFGASQNPQTPPQWPSSTRATPSHPSQPSQPSQQPPLPGFASYRPQKPQPNSYDLSYGGGPQPAPAGTGRPGFGLGISSTTSTTTTAKPITSTTGKTPQQKEDFPALPGPRRPSQKEDFPALPAPKTPPGSPTPTPGSPSAWQSPLPTPQHPVHPPTKATSAATPTPTPTPSFSSSVTPTPAHGSSVGPHKDGGGGGGGGTTTVRPGFQSSGNSVATDDEIRQLTELLYTKESNSQIGNIQVNLQGRTRSIDSADEAPNPLLTVDSKALESPTIVKMRLLFNNYEHDTHVNEHVTPNERKEENDFLDAVMATPVMRQAMLFLQQKGVVSPDPKTHRDLVKELWFTQYSRGQGKIGSSGFEHVFVYEVKDGTIIGFHNWVYIGDEEKDGRFDYKGYMKEQDIGTKGKIVKIRFSHQGLNKPVNTVFVGTSPELELALYTVCFQLRPDRTCPVSLGNSKFGIVTYSWRYRGKNLIGSAYPEI
Protein: Fork head domain protein FKD8 (Forkhead box protein D5) (O73784)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MTLSQDYEQVQRTPISPEDDEIDIVGGDHSDSEREYFMRDPTEVDHSGSESSGESESDFASSTVAPKQSSSVKPPYSYIALITMAILQSPMKKLTLSGICDFISNKFPYYKEKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWSLDPASEDMFDNGSFLRRRKRFKRNQPEFTKDSLVLYHPTLSYRAYGRPYCVSGAVPAQTNPVGYLPVPDGIMVPPPFFQYQTMNIKIHDAPEIQQRPEHKTQRCSFSIDSIMAKSTESSSKSSAHHLTPDYSFVFPRPTTSCVAPSLVPVPTRTPLLKTVPFSETLRMVYPHC
Protein: WRKY-related protein 1 (I1MBG9)
Organism: Glycine max (Soybean) (Glycine hispida)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- WRKY domain-containing protein
- Autophagy-related protein
- PX domain-containing protein
- PX domain-containing protein
- Transcription factor
Sequence:
MPFRNSNMIVQKKLWRIVGFLSSVIGLICYALSSSFNHLFGEWNFLKIILYAVISFSISSIMLLLKKWKLSKSFMLKAHVGVLVLLITSVYSFVSDKAVNGKPDMLSLISCFAFAFMSLCLSKQIDLGFGADLLNFFLGCLTVQLMHIHLMLSIVAAIFCYCFMFFRSKLDSQSQIGTVEVEDHVNIEIDAEDGKREFDDNRSDFQANHSHQQVPLLRMVGDGYNWRKYEDKVVKGSANQLSYYKCTQPTCYVKKKVERTIEGEIVDIHYQGTHTHCERMHNMKRNSSSEYLYSVLPSEPVTFPDQSFASQGNGELDYHVQQQRTPQYPNEI
Protein: Dihydroflavonol 4-reductase (DFR) (EC 1.1.1.219) (Dihydrokaempferol 4-reductase) (Flavanone 4-reductase) (FNR) (EC 1.1.1.234) (Protein TRANSPARENT TESTA 3) (P51102)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional enzyme involved in flavonoid metabolism.
Interaction partners:
- Leucoanthocyanidin dioxygenase
- 2-oxoglutarate
- Flavonoid 3'-monooxygenase
- Naringenin,2-oxoglutarate 3-dioxygenase
- Flavonol synthase/flavanone 3-hydroxylase
- Probable flavonol synthase 5
- Flavonol synthase 3
- Probable flavonol synthase 4
- Probable flavonol synthase 6
- Anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase
Sequence:
MVSQKETVCVTGASGFIGSWLVMRLLERGYFVRATVRDPGNLKKVQHLLDLPNAKTLLTLWKADLSEEGSYDDAINGCDGVFHVATPMDFESKDPENEVIKPTVNGMLGIMKACVKAKTVRRFVFTSSAGTVNVEEHQKNVYDENDWSDLEFIMSKKMTGWMYFVSKTLAEKAAWDFAEEKGLDFISIIPTLVVGPFITTSMPPSLITALSPITRNEAHYSIIRQGQYVHLDDLCNAHIFLYEQAAAKGRYICSSHDATILTISKFLRPKYPEYNVPSTFEGVDENLKSIEFSSKKLTDMGFNFKYSLEEMFIESIETCRQKGFLPVSLSYQSISEIKTKNENIDVKTGDGLTDGMKPCNKTETGITGERTDAPMLAQQMCA
Protein: Protein RD3 (Retinal degeneration protein 3) (Q7Z3Z2)
Organism: Homo sapiens (Human)
Function: Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina (By similarity).
Subcellular location: Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q8BRE0}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8BRE0}. Endosome {ECO:0000250|UniProtKB:Q8BRE0}. Nucleus {ECO:0000269|PubMed:26100624, ECO:0000269|PubMed:29030614}. Cytoplasm {ECO:0000269|PubMed:26100624, ECO:0000269|PubMed:29030614}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:29030614}. Note=Colocalizes with GUCY2E and GUCY2F in rods and cones photoreceptors. Colocalizes with GUK1 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer (By similarity). Strong dot-like perinuclear staining in the epithelial cells (PubMed:29030614). {ECO:0000250|UniProtKB:Q8BRE0, ECO:0000269|PubMed:29030614}.
Interaction partners:
- Retinal guanylyl cyclase 1
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
- Peripherin-2
- Spermatogenesis-associated protein 7
- Lebercilin
- Aryl-hydrocarbon-interacting protein-like 1
- X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
- Retinol dehydrogenase 12
- Retinoid isomerohydrolase
- Lecithin retinol acyltransferase
Sequence:
MSLISWLRWNEAPSRLSTRSPAEMVLETLMMELTGQMREAERQQRERSNAVRKVCTGVDYSWLASTPRSTYDLSPIERLQLEDVCVKIHPSYCGPAILRFRQLLAEQEPEVQEVSQLFRSVLQEVLERMKQEEEAHKLTRQWSLRPRGSLATFKTRARISPFASDIRTISEDVERDTPPPLRSWSMPEFRAPKAD
Protein: Putative membrane fusion protein (Q9RG60)
Organism: Pseudomonas aeruginosa
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004519}.
Interaction partners:
Sequence:
MHIQWTGSLRGLLAALVALFLLGCEEAADAGKTAEAPAEVGVIVARPAPIGITSELPGRLEAYRQAEVRARVAGIVTRRLYEEGQDVRAGTVLFQIDPAPLKAALDISRGALARAEASHAAAADKLKRYADLIKDRAISEREYTEAQTDARQALAQIASAKAELEQARLRLGYATVTAPIDGRARRALVTEGALVGEDSPTPLTRVEQIDPIYVNFSQPAGEVAAMQRAIREGQVKGVADKDIAVRLVLADGSEYPLAGELLFSDLAVDPGTDTIAMRALFRNPHRELLPGGYVQVRLQRAVNPQAITVPRDALIRTAQSAVVKVVNPKGLVEDVEVRADTLQGRDWIISRGLKGGEWVIVENAAQHAAGSSVQAVVRQPASADAPSPLAASPAGQ
Protein: RNA binding protein (Autoantigenic, hnRNP-associated with lethal yellow) long isoform variant (RNA binding protein, autoantigenic (HnRNP-associated with lethal yellow homolog (Mouse))) (cDNA FLJ77422, highly similar to Homo sapiens RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)), transcript variant 1, mRNA) (Q53GL6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLKLQASNVTNKNDPKSINSRVFIGNLNTALVKKSDVETIFSKYGRVAGCSVHKGYAFVQYSNERHARAAVLGENGRVLAGQTLDINMAGEPKPDRPKGLKRAASAIYSGYIFDYDYYRDDFYDRLFDYRGRLSPVPVPRAVPVKRPRVTVPLVRRVKTNVPVKLFARSTAVTTSSAKIKLKSSELQAIKTELTQIKSNIDALLSRLEQIAAEQKANPDGKKKGDGGGASGGGGGGGGSGGGGSGGGGGGGSSRPPAPQENTTSEAGLPQGEARTRDDGDEEGLLTHSEEELEHSQDTDADDGALQ
Protein: E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (RING finger protein 14) (F1RB95)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UBS8}. Nucleus {ECO:0000250|UniProtKB:Q9UBS8}.
Interaction partners:
- Family with sequence similarity 177 member A1.
Sequence:
MSADQEAKEDELLALASIYDEEEFHRAESGKEGEIHLCLELPPNFKLLVKGQKSAEHNISFLPPLVLSFDLPDDYPSTSAPIFTISSKWLTRVQITALCRKLDELWEENQGNVVLFTWIQFLKEETLDFLGIQSPLEIQRSGSQPQCEPAQKHAADASGEKSKVQDLDPRAVQEVDAQTDILTQLLDFDEAQKQRVFDGKAFCCGICYSEKLGCDCLLFKECEHVYCKACIKEYFQIQIKDGKVQCLNCPEPKCASTATPTQVKLLVGEDEFARYDRLLLQSSLDLMADVVYCPRMSCCMAVMVEPDSTMGICPSCRYAFCTLCRRSYHGLSHCIATADELRSLRDEYLSSSEEGKKFLEKRFGKRVIQRAVEESFSTDWLKTNCKQCPCCGTNIQKAHGCNKMTCSSCQKYFCWICLGALSRVNPYSHFNNPDSPCYNQLFHGMEMEEDEAFGSDEDD
Protein: General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) (Q9Z1Z0)
Organism: Mus musculus (Mouse)
Function: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recycles between the cytosol and the Golgi apparatus during interphase. {ECO:0000250}.
Interaction partners:
- Syntaxin-5
- Golgi SNAP receptor complex member 1
- Golgi SNAP receptor complex member 2
- BET1-like protein
- BET1-like protein
- Ras-related protein Rab-1A
- Golgin B1
- Sec1 family domain-containing protein 1
- BET1 homolog
- Ras-related protein Rab-1B
Sequence:
MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTDRSDSEIIAYALDTLYNIISNDEEEELEENSTRQSEDLGSQFTEIFIKQPENVTLLLSLLEEFDFHVRWPGVRLLTSLLKQLGPPVQQIILVSPMGVSRLMDLLADSREIIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIITEEGNSDGGIVVEDCLILLQNLLKTNNSNQNFFKEGSYIQRMKPWFEVGEENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGIPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNEKGQGEIVATLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQGNATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLENYTKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELKQQVSTLKCQNEQLQTAVTQQASQIQQHKDQYNLLKVQLGKDNHHQGSHGDGAQVNGIQPEEISRLREEIEELKSQQALLQGQLAEKDSLIENLKSSQASGMSEQASATCPPRDPEQVAELKQELTALKSQLCSQSLEITRLQTENCELLQRAETLAKSVPVEGESEHVSAAKTTDVEGRLSALLQETKELKNEIKALSEERTAIQKQLDSSNSTIAILQTEKDKLDLEVTDSKKEQDDLLVLLADQDQKILSLKSKLKDLGHPVEEEDESGDQEDDDDEIDDGDKDQDI
Protein: Forkhead box protein N4 (A2BGM5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Interaction partners:
- BarH-class homeodomain transcription factor
- Pancreas transcription factor 1 subunit alpha
- Visual system homeobox 2
- Transcription factor atoh7
- Class E basic helix-loop-helix protein 22
- T-box transcription factor TBX2b
- POU domain protein
- Neurogenic differentiation factor 1
- Visual system homeobox 1
- LIM/homeobox protein Lhx1
Sequence:
MTVQSKLQGRGKFKKRFFRAGQQVPRPTLELSSVWLSKIFYNPEQHHNKQKMIESGITTRMSGIHENPGQSHHTSAQDYRLLTTDPSQLKDELPGDLQSLSWLTSVDVPRLQQIGGGRPDFTSSAQSSLLERQTAQLNSMTVAGGAGSAIHLQSEMQHSPLAINSMPQFSPGFPCAASVYQTAPQQVLTFTQANQQCSPGGLYGNYNSQNLFPQPRITAHSQDLQPKCFPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKMSGSSRKGCLWALNPAKIDKMEEEMQKWKRKDLPAIRRSMANPDELDKLITDRPESCRQKSVDPGMTRLPSCPPGQTLPLAAQMQPQPVVTLSLQCLPMHQHLQLQLQNQSRLAPSSPAPAQTPPLHTVPDMTNSSLPQHPAKQHTDFYTVHTDVNSEVDALDPSIMDFAWQGNLWEEMKDDSFNLEALGTLSNSPLRLSDCDLDTSSVTPVSSAGGLPYPDLQVTGLYSSYSAIDALSNQYMNTQGGTKPIVLL
Protein: Flagellar biosynthesis protein FlhF (Flagella-associated GTP-binding protein) (Q44758)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Function: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Flagellar biosynthesis protein FlhA
- ATP-binding protein
- Flagellar motor switch protein FliM
- Flagellar biosynthetic protein FlhB
- Flagellar M-ring protein
- Flagellar protein FliZ
- Purine-binding chemotaxis protein
- Flagellar biosynthetic protein FliR
- Flagellar assembly protein FliH
- ATP-binding protein
Sequence:
MVQYFTEKGPTYNEVIEIIKKKYGKNARVMTYKTVPHGGILGLFSKDWVEVSGYVRYDIGNQQINVEDEKRKILQSIKREENSSIEDVLKEVKSLKTELAHKKENINHPTITKIEDILRENDFSENYIKDINEFIKREFSLSDLDDYERVREDVVLYIAKTIKCSGSIIDNLKKRVFILVGPTGVGKTTTIAKLAAIYGINGESKSLNIKIITIDNYRIGAKKQIQTYGDIMGIPVRAIESFKDLKDEITDSKDFDLILVDTIGKSPKDFMKLAEMKELLNACGRDAEFHLAVSSTTKTSDVKEIFHQFSPFNYKTVIFTKVDETTCVGNLISLIYEMKKVVSYVTDGQIVPHNISVAEPLTFIRRINGYRISDDAEFIKKIKSKSYY
Protein: Altered inheritance of mitochondria protein 36, mitochondrial (Found in mitochondrial proteome protein 39) (Q03798)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:14562095}; Single-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MLRPLRKSVLASCRHCFKVCGGLPQKQLPLFSPLLLRARYSSTDSSTKRSNKSDKIDAPGFKKIFLVAIIGTVIFVKTVQSLDKNKPKTTLSEEEFENVVKGLKRRVAIFPQGEVDIKFSLSPSIEETRKVLQKSQGDDINELQFVDPVKVIDYYRTLRDDRYEALLNEYYKKYGCDTYAYNLPTGMLVMLLGRYFKENFKTGDKLVVVNFPHSIADATRFENEVSIVSKIFVPRKLSGSDVCKYYETVGKADII
Protein: Putative cell agglutination protein pfl6 (Adhesin pfl6) (Pombe flocculin 6) (P0CU05)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in agglutination during conjugation or other aspects of colony formation (By similarity). Induces flocculation when overexpressed.
Subcellular location: Cell surface {ECO:0000305|PubMed:17870620}.
Interaction partners:
Sequence:
MNFFLYFRTIFLIQLYFFNYSTFGCSASSTSVQSDTTNQVSVSCPKYTTIYTSGTSPDTKTIYPESTSTKSITTSTQSHSSPVIVVSTVGTVTETTISGSTEYTTTIPAEGITSGTVEIVEPTAGTVTETITSGTLPFTTTLAQASGTVSGTVEIVSPKNNPTTVYSGTVATTETFSSSTVVVIPTAICDGVRGLEYAVYDYTISSSMNEFCYPKNGQTDVFAFNEPAYFGSSDLDQSSPLFTGVFSSTDDIPEWASSWYLPPYPPQASDMASTYCACKVIVYQFFLRIPETDTYTLVVNNVDDVFFGWFGDKAISGWSNNNFDAYSYWHESPNMGLGTVGMGNFTVGNYPEGYFLPVRFVVANGAYIGGFDFYFTSDSTGPLATTSYSYTKTCTQQFLPFGQGNGGVNGPTEKLS
Protein: Appendage-associated protein (Q5SF93)
Organism: Anaplasma marginale (strain Virginia)
Function: Associates with actin filament appendages that are formed in the inclusion appendages of the parasitophorous vacuole during infection of the host erythrocyte.
Subcellular location: Secreted {ECO:0000269|PubMed:15557651}.
Interaction partners:
Sequence:
MSRGGSPGCGRRIAEELRLAEDARLRLALLGRCIVKGSPAQVRKELRAELKAIDAEWRPVIARESLRKELDAIDAEWQHAITFWHISRAIIGSIELSKELDAIDAEWRPVIVRESLRKELKAIDAEWRPAIRLESAYRAIIGSIELSKELKAIDAETQHAVELRRALRTIEGRIELSRELKAIDAEWAPRIAQAKEIAQARESLRKELNDIDAEWAPKIAQAKEIAQAKAELAAATDALKRAADKLQALGKMDTTSTPGTDLIGVVTTAVTTTLAGTQPAPGTDLVGVATPSTALGQPAPSTALTSVAAEVATPSTALGV
Protein: Lactotransferrin (Lactoferrin) (EC 3.4.21.-) (P08071)
Organism: Mus musculus (Mouse)
Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
Subcellular location: Secreted. Cytoplasmic granule {ECO:0000250}. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils (By similarity). {ECO:0000250}.
Interaction partners:
- Myeloperoxidase
- Cathepsin G
- Neutrophil gelatinase-associated lipocalin
- Neutrophil elastase
- Alpha-lactalbumin
- Albumin
- Clusterin
- Myeloblastin
- Transferrin receptor protein 1
- Low-density lipoprotein receptor-related protein 2
Sequence:
MRLLIPSLIFLEALGLCLAKATTVQWCAVSNSEEEKCLRWQNEMRKVGGPPLSCVKKSSTRQCIQAIVTNRADAMTLDGGTMFDAGKPPYKLRPVAAEVYGTKEQPRTHYYAVAVVKNSSNFHLNQLQGLRSCHTGIGRSAGWKIPIGTLRPYLNWNGPPASLEEAVSKFFSKSCVPGAQKDRFPNLCSSCAGTGANKCASSPEEPYSGYAGALRCLRDNAGDVAFTRGSTVFEELPNKAERDQYKLLCPDNTWKPVTEYKECHLAQVPSHAVVSRSTNDKEEAIWELLRQSQEKFGKKQASGFQLFASPSGQKDLLFKESAIGFVRVPQKVDVGLYLTFSYTTSIQNLNKKQQDVIASKARVTWCAVGSEEKRKCDQWNRASRGRVTCISFPTTEDCIVAIMKGDADAMSLDGGYIYTAGKCGLVPVLAENQKSSKSNGLDCVNRPVEGYLAVAAVRREDAGFTWSSLRGKKSCHTAVDRTAGWNIPMGLLANQTRSCKFNEFFSQSCAPGADPKSNLCALCIGDEKGENKCAPNSKERYQGYTGALRCLAEKAGNVAFLKDSTVLQNTDGKNTEEWARNLKLKDFELLCLDDTRKPVTEAKNCHLAIAPNHAVVSRTDKVEVLQQVLLDQQVQFGRNGQRCPGEFCLFQSKTKNLLFNDNTECLAKIPGKTTSEKYLGKEYVIATERLKQCSSSPLLEACAFLTQ
Protein: Paracaspase (EC 3.4.22.-) (Q9GPM2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not required for DIF-induced autophagic cell death and necrotic cell death.
Interaction partners:
- Vacuolar proton translocating ATPase 100 kDa subunit
Sequence:
MSETFIHSVSENQIIVNDLENNNDYDNEDNVFIDSSVYNQECFMEILKKLEDGKPIHEVVRFTSHSSYTHTIVKTIQGLFLYVVLKSVNIYGSYYDFQRYIGPSMMIGTYACPLYRVQYRINKNDSTGAIIKYSNNLDECETYFNHLCKVFNVLTKRLSLNSICCGVGLSDSFYLMNTKTIKKSSRTRISFIIGNSKYSQHRKLDGVINDVNSFYCALLGCSFHSDNIVWLIDSDLRTFYDKWYTFLQLVQSFQSYIEVVVYYAGHGRSDNGNLKLIMTDGNPVQLSIIASTLTESIKNSDSLCLFIVDCCRDGENVLPFHYPIESFDDKKNIAVLFACKYGELSYESLELNAGIFTRSFVKTITERKNNNISTICNLTDIAIKRIYKNYSGCSLIGNFDCSLLEF
Protein: E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A) (Q5VTR2)
Organism: Homo sapiens (Human)
Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
Subcellular location: Nucleus {ECO:0000269|PubMed:19037095, ECO:0000305|PubMed:16337599}.
Interaction partners:
- E3 ubiquitin-protein ligase BRE1B
- Ubiquitin-conjugating enzyme E2 A
- Ubiquitin-conjugating enzyme E2 B
- Parafibromin
- Histone H2B type 2-E
- RNA polymerase II-associated factor 1 homolog
- WW domain-containing adapter protein with coiled-coil
- RNA polymerase-associated protein RTF1 homolog
- Ubiquitin-conjugating enzyme E2 N
- Histone H2B type 1-B
Sequence:
MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYIG
Protein: DNA-binding protein RAP1 (Repressor/activator site-binding protein) (SBF-E) (TUF) (P11938)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96TL7}. Chromosome, telomere {ECO:0000250|UniProtKB:Q96TL7}.
Interaction partners:
- Regulatory protein SIR3
- Protein RIF2
- Telomere length regulator protein RIF1
- Pre-rRNA-processing protein FHL1
- ARS-binding factor 1
- Regulatory protein SIR4
- Protein IFH1
- Transcription initiation factor TFIID subunit 1
- Glycolytic genes transcriptional activator GCR1
- Cell division control protein 13
Sequence:
MSSPDDFETAPAEYVDALDPSMVVVDSGSAAVTAPSDSAAEVKANQNEENTGATAAETSEKVDQTEVEKKDDDDTTEVGVTTTTPSIADTAATANIASTSGASVTEPTTDDTAADEKKEQVSGPPLSNMKFYLNRDADAHDSLNDIDQLARLIRANGGEVLDSKPRESKENVFIVSPYNHTNLPTVTPTYIKACCQSNSLLNMENYLVPYDNFREVVDSRLQEESHSNGVDNSNSNSDNKDSIRPKTEIISTNTNGATEDSTSEKVMVDAEQQARLQEQAQLLRQHVSSTASITSGGHNDLVQIEQPQKDTSNNNNSNVNDEDNDLLTQDNNPQTADEGNASFQAQRSMISRGALPSHNKASFTDEEDEFILDVVRKNPTRRTTHTLYDEISHYVPNHTGNSIRHRFRVYLSKRLEYVYEVDKFGKLVRDDDGNLIKTKVLPPSIKRKFSADEDYTLAIAVKKQFYRDLFQIDPDTGRSLITDEDTPTAIARRNMTMDPNHVPGSEPNFAAYRTQSRRGPIAREFFKHFAEEHAAHTENAWRDRFRKFLLAYGIDDYISYYEAEKAQNREPEPMKNLTNRPKRPGVPTPGNYNSAAKRARNYSSQRNVQPTANAASANAAAAAAAAASNSYAIPENELLDEDTMNFISSLKNDLSNISNSLPFEYPHEIAEAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSGDLMVFPRYFLNMFKDNVNPPPNVPGIWTHDDDESLKSNDQEQIRKLVKKHGTGRMEMRKRFFEKDLL