wanglab/gogpt-training-data huggingface dataset:
Protein: MOB kinase activator-like 1A (Mob1 homolog 1A) (Mps one binder kinase activator-like 1A) (Q9FHI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a key role in regulation of cell expansion and cell division. Required for proper plant development, the correct patterning of the root meristem and the control of root growth. Involved in both sporogenesis and gametogenesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:15469496, ECO:0000269|PubMed:21641974, ECO:0000269|PubMed:26685188}. Cell membrane {ECO:0000269|PubMed:26685188}. Vacuole membrane {ECO:0000269|PubMed:26685188}. Note=Observed at the plasma membrane and in the nucleus when associated with SIK1. {ECO:0000269|PubMed:26685188}.
Interaction partners:
- Zinc finger CCCH domain-containing protein 24
- Oxysterol-binding protein-related protein 1D
- tRNA wybutosine-synthesizing protein 2/3/4
- AT3g17020/K14A17_14
- Protein NLP2
- Sugar transport protein 2
- Rop guanine nucleotide exchange factor 14
- Protein NLP1
- Protein NLP3
- 65-kDa microtubule-associated protein 6
Sequence:
MSLFGLGRNQKTFRPKKSAPSGSKGAQLRKHIDATLGSGNLREAVRLPPGEDANEWLAVNTVDFFNQVNLLYGTLTEFCTPDNCPTMTAGPKYEYRWADGVQIKKPIEVSAPKYVEYLMDWIETQLDDETLFPQRLGAPFPQNFKDVVKTIFKRLFRVYAHIYHSHFQKIVSLKEEAHLNTCFKHFILFTHEFGLIDKKELAPLQELIESIISPY
Protein: WW domain-binding protein 2 (WBP-2) (Q969T9)
Organism: Homo sapiens (Human)
Function: Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21642474}. Nucleus {ECO:0000269|PubMed:21642474}. Note=Translocates from cytoplasm to nucleus when phosphorylated. {ECO:0000269|PubMed:21642474}.
Interaction partners:
- Transcriptional coactivator YAP1
- WW domain-binding protein 1
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome b-c1 complex subunit 7
- NEDD4-like E3 ubiquitin-protein ligase WWP2
- E3 ubiquitin-protein ligase NEDD4
- E3 ubiquitin-protein ligase NEDD4-like
- WW domain-containing oxidoreductase
Sequence:
MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVIFLSKGKDAMQSFMMPFYLMKDCEIKQPVFGANYIKGTVKAEAGGGWEGSASYKLTFTAGGAIEFGQRMLQVASQASRGEVPSGAYGYSYMPSGAYVYPPPVANGMYPCPPGYPYPPPPPEFYPGPPMMDGAMGYVQPPPPPYPGPMEPPVSGPDVPSTPAAEAKAAEAAASAYYNPGNPHNVYMPTSQPPPPPYYPPEDKKTQ
Protein: Uncharacterized protein (Q388Y2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MARCIIGARRVTFWSMEQFACLLRSFHRNGQVVVNKNESSQRFASLRPFLIDLPYSAAMKLLIRLFMLSFHFYQFVWCVALVGYFIYIYIFVKVIGCAPQQLLFLCSAREG
Protein: Voltage-gated potassium channel KCNC4 (Potassium voltage-gated channel subfamily C member 4) (Raw3) (Voltage-gated potassium channel subunit Kv3.4) (Q63734)
Organism: Rattus norvegicus (Rat)
Function: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Voltage-gated potassium channel subunit beta-3
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Ubiquitin-like protein FUBI
- Voltage-gated potassium channel subunit beta-1
- Voltage-gated potassium channel subunit beta-2
Sequence:
MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGGGAGPGDEAGDDERELALQRLGPHEGGSGPGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIHRVGNITSVRFRREVETEPILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPPQLESPIYCKSEETSPRDSTYSDTSPPAREEGMVERKRADSKQNGDANAVLSDEEGAGLTQPLASAPTPEERRALRRSGTRDRNKKAAACFLLSAGDYACADGSVQKEGSVEPKACVPVSHTCAL
Protein: Coiled-coil and C2 domain-containing protein 2A (Q9P2K1)
Organism: Homo sapiens (Human)
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}.
Interaction partners:
- Meckelin
- Tectonic-1
- B9 domain-containing protein 1
- Tectonic-like complex member MKS1
- B9 domain-containing protein 2
- Transmembrane protein 216
- Centrosomal protein of 290 kDa
- Tectonic-2
- Jouberin
- Transmembrane protein 231
Sequence:
MNPREEKVKIITEEFIENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQARIDGTFKIDIPPVLLGYSKERNMILERGFDSVRSLSEGSYITLFITIEPQLVPGESIREKFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR
Protein: Nebulin (Q04020)
Organism: Oryctolagus cuniculus (Rabbit)
Interaction partners:
Sequence:
ANKLNMDKRLYTKKWDKDKTTIHVMPDTPDILLSRVNQITMSDKLYRAGWEEEKKKGYDLRPDAISIKAAKASRDIASDYKYKQAYEQAKGKHIGFRSLEDDPKLVHFMQVAKMQSDREYKKAYEKSKTSFHTPVDMLSVVAAKKSQEVATNANYRNVIHTYNMLPDAMGFELAKNMMQ
Protein: Secreted effector protein (A0A0F6AZQ1)
Organism: Salmonella typhimurium (strain 14028s / SGSC 2262)
Subcellular location: Host membrane {ECO:0000256|ARBA:ARBA00004551}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MPITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERWFREVIGKLTTSLLYVNKNAFFDGNKIFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDKVDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVNLAHKDFQGEDLSKIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSDLTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDRTLFPHPIF
Protein: Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) (GABAAR subunit gamma-2) (P18507)
Organism: Homo sapiens (Human)
Function: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:2538761}; Multi-pass membrane protein {ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53}. Cell membrane {ECO:0000269|PubMed:2538761, ECO:0000269|PubMed:27864268}; Multi-pass membrane protein {ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53}. Cell projection, dendrite {ECO:0000250|UniProtKB:P22723}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P18508}.
Interaction partners:
- Gamma-aminobutyric acid receptor subunit alpha-1
- Gamma-aminobutyric acid receptor subunit beta-3
- Gamma-aminobutyric acid receptor subunit beta-2
- Sodium channel protein type 1 subunit alpha
- Sodium channel regulatory subunit beta-1
- Gamma-aminobutyric acid receptor subunit alpha-4
- Gamma-aminobutyric acid receptor-associated protein
- Chloride channel protein 2
- Gamma-aminobutyric acid type B receptor subunit 1
- Gamma-aminobutyric acid receptor subunit beta-1
Sequence:
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
Protein: RAR-related orphan receptor A (A0A8I6A803)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MESAPAAPDPAASEPGSSGSEAAAGSRETPLTQDAGRKSEAPGAGRRQSYASSSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSTYMDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
Protein: Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) (O60716)
Organism: Homo sapiens (Human)
Function: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.
Subcellular location: Cell junction, adherens junction {ECO:0000269|PubMed:11896187}. Cytoplasm {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Nucleus {ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:17115030}. Cell membrane {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Cell junction {ECO:0000269|PubMed:18343367}. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:P30999, ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}.; SUBCELLULAR LOCATION: [Isoform 1A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 2A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 3A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 4A]: Cytoplasm {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 1AB]: Cytoplasm {ECO:0000269|PubMed:11896187}.
Interaction partners:
- Cadherin-1
- Cadherin-17
- Transcriptional regulator Kaiso
- Cadherin-2
- Catenin beta-1
- Cadherin-5
- Afadin
- Catenin alpha-1
- Epidermal growth factor receptor
- Transforming protein RhoA
Sequence:
MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQVSYPSMQKI
Protein: Uncharacterized protein (Q2GL86)
Organism: Anaplasma phagocytophilum (strain HZ)
Interaction partners:
Sequence:
MIPLAPWKSISVVYMSGSDEYKEIIKQCIGSVKEVFGEGRFDDVVASIMKMQEKVLASSMQQDDTGTVGQIESGEGSGARLSDEQVQQLMNSIREEFKDDLRAIKRRILKLERAVYGANTPKES
Protein: Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) (Q6P9R2)
Organism: Mus musculus (Mouse)
Function: Phosphorylates RELL1, RELL2, RELT and PAK1. Phosphorylates PLSCR1 in the presence of RELT.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O95747}.
Interaction partners:
- Solute carrier family 12 member 2
- Translocation protein SEC62
- Protein transport protein Sec61 subunit gamma
- Translocation protein SEC63 homolog
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Solute carrier family 12 member 6
- Protein transport protein Sec61 subunit alpha isoform 2
- Protein transport protein Sec61 subunit alpha isoform 1
- Serine/threonine-protein kinase WNK1
Sequence:
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKERVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEPTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKILQRAPTISERSKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGRAAISQLRSPRVKDSLSSSELFAAAEPMGTLLQVPEQISAHLPQPAGQMPTQPAQVSLLPPAEPAKPAQAQSSGERSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
Protein: Galectin (G5EBV4)
Organism: Caenorhabditis elegans
Interaction partners:
- Bacterial colonization factor
- C-type LECtin
- C-type LECtin
- Galectin
- Galactoside 2-alpha-L-fucosyltransferase
- Galectin
Sequence:
MHSYHNPGVPTALSIFEPLQDGSTISVHGHVRHGHHKNFAVELLSGPNVVLHVNFRFHHEHVVVMNSQFSGMWGPEIRHKNPLHHSEHFHLSIKVHAGYYHISVNGHHLADYPHRYPYQSVQAIGLKGDVHVDKVHFEGFHFQRRWDGHVDHGHSGYNAYGTETYVAPVFVQPNFMPYGAPPPPVQNFNPYR
Protein: Guanine nucleotide-binding protein subunit beta-1 (P93397)
Organism: Nicotiana tabacum (Common tobacco)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Interaction partners:
- Guanine nucleotide-binding protein alpha subunit
- Guanine nucleotide-binding protein alpha-1 subunit.
- Extra-large guanine nucleotide-binding protein 1
- Extra-large guanine nucleotide-binding protein 1
- Extra-large guanine nucleotide-binding protein 1
- Extra-large guanine nucleotide-binding protein 1
- Extra-large guanine nucleotide-binding protein 3
- Extra-large guanine nucleotide-binding protein 3
- Extra-large guanine nucleotide-binding protein 3-like
- Extra-large guanine nucleotide-binding protein 3-like
Sequence:
MSVTELKERHMAATQTVNDLREKLKQKRLQLLDTDVSGYARSQGKTPVTFGPTDLVCCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPSGQSVACGGLDSVCSIFNLNSPIDKDGNHPVSRMLSGHKGYVSSCQYVPDEDTHLITSSGDQTCVLWDITTGLRTSVFGGEFQSGHTADVQSVSISSSNPRLFVSGSCDTTARLWDTRVASRAQRTFYGHEGDVNTVKFFPDGNRFGTGSEDGTCRLFDIRTEHQLQVYYQPHGDGDIPHVTSMAFSISGRLLFVGYSNGDCYVWDTLLAKVVLNLGGVQNSHEGRISCLGLSADGSALCTGSWDTNLKIWAFGGHRSVI
Protein: DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 130 kDa polypeptide) (P22276)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC8
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerase III subunit RPC7
- DNA-directed RNA polymerases I and III subunit RPAC2
- DNA-directed RNA polymerase III subunit RPC5
- DNA-directed RNA polymerase III subunit RPC10
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
Sequence:
MVAATKRRKTHIHKHVKDEAFDDLLKPVYKGKKLTDEINTAQDKWHLLPAFLKVKGLVKQHLDSFNYFVDTDLKKIIKANQLILSDVDPEFYLKYVDIRVGKKSSSSTKDYLTPPHECRLRDMTYSAPIYVDIEYTRGRNIIMHKDVEIGRMPIMLRSNKCILYDADESKMAKLNECPLDPGGYFIVNGTEKVILVQEQLSKNRIIVEADEKKGIVQASVTSSTHERKSKTYVITKNGKIYLKHNSIAEEIPIAIVLKACGILSDLEIMQLVCGNDSSYQDIFAVNLEESSKLDIYTQQQALEYIGAKVKTMRRQKLTILQEGIEAIATTVIAHLTVEALDFREKALYIAMMTRRVVMAMYNPKMIDDRDYVGNKRLELAGQLISLLFEDLFKKFNNDFKLSIDKVLKKPNRAMEYDALLSINVHSNNITSGLNRAISTGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISSQFEKSRKVSGPRALQPSQFGMLCTADTPEGEACGLVKNLALMTHITTDDEEEPIKKLCYVLGVEDITLIDSASLHLNYGVYLNGTLIGSIRFPTKFVTQFRHLRRTGKVSEFISIYSNSHQMAVHIATDGGRICRPLIIVSDGQSRVKDIHLRKLLDGELDFDDFLKLGLVEYLDVNEENDSYIALYEKDIVPSMTHLEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQFKRIDTLLYLMTYPQQPMVKTKTIELIDYDKLPAGQNATVAVMSYSGYDIEDALVLNKSSIDRGFGRCETRRKTTTVLKRYANHTQDIIGGMRVDENGDPIWQHQSLGPDGLGEVGMKVQSGQIYINKSVPTNSADAPNPNNVNVQTQYREAPVIYRGPEPSHIDQVMMSVSDNDQALIKVLLRQNRRPELGDKFSSRHGQKGVCGIIVKQEDMPFNDQGIVPDIIMNPHGFPSRMTVGKMIELISGKAGVLNGTLEYGTCFGGSKLEDMSKILVDQGFNYSGKDMLYSGITGECLQAYIFFGPIYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCVIAYGASQLLLERLMISSDAFEVDVCDKCGLMGYSGWCTTCKSAENIIKMTIPYAAKLLFQELLSMNIAPRLRLEDIFQQ
Protein: Zona pellucida sperm-binding protein 2 (Zona pellucida glycoprotein 2) (Zp-2) (Zona pellucida protein A) [Cleaved into: Processed zona pellucida sperm-binding protein 2] (P47983)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
Subcellular location: [Processed zona pellucida sperm-binding protein 2]: Zona pellucida {ECO:0000250|UniProtKB:P20239}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20239}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Zona pellucida sperm-binding protein 3
- Growth differentiation factor 9.
- Zona pellucida glycoprotein 4.
- Folliculogenesis specific bHLH transcription factor.
- Oviductal glycoprotein 1
- Bone morphogenetic protein 15.
- NLR family pyrin domain containing 5.
Sequence:
MACKQKGDSGSPSSRFSADWSTYRSLSLFFILVTSVNSVGVMQLVNPIFPGTVICHENKMTVEFPRDLGTKKWHASVVDPFSFELLNCTSILDPEKLTLKAPYETCSRRVLGQHQMAIRLTDNNAASRHKAFMYQISCPVMQTEETHEHAGSTICTKDSMSFTFNIIPGMADENTNPSGGKWMMEVDDAKAQNLTLREALMQGYNFLFDSHRLSVQVSFNATGVTHYMQGNSHLYTVPLKLIHTSPGQKIILTTRVLCMSDPVTCNATHMTLTIPEFPGKLQSVRFENTNFRVSQLHNHGIDKEELNGLRLHFSKSLLKMNSSEKCLLYQFYLASLKLTFAFERDTVSTVVYPECVCEPPVTIVTGDLCTQDGFMDVKVYSHQTKPALNLDTLRVGDSSCQPTFKAPSQGLTLFHIPLNGCGTRLKFKGDTVIYENEIHALWTDLPPSTISRDSEFRMTVKCHYSRDDLLINTNVQSLPPPVASVRPGPLALILQTYPDKSYLRPYGDKEYPVVRYLRQPIYLEVKVLNRADPNIKLVLDDCWATPTMDPASLPQWNIVMDGCEYNLDNYRTTFHPVGSSVTYPTHYQRFDVKTFAFISEAQVLSSLVYFHCTALICNRLSPDSPLCSVTCPVSSRHRRATGSTEEEKMIVSLPGPILLLADSSSLRDGVDSKGHRAAGYVAFKTVVAVAALAGLVAALGLIIYLRKKRTMVLNH
Protein: Phospholipid/glycerol acyltransferase domain-containing protein (Q1ZXU8)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MPEDFQHKKPRRSSSASDLGIINREKSDIIDAKLHETNVPEAKQTTVSVLVDDTLDFITAGMEAVIEDQVTNRFSAAQLPSWNLLSRTKYSFHFFNWQLTLLWIAGFMFRYYVLVPCRIALFGIAIVLMIVSTSIIGLVPNAKVRKFLNRRCMLMCMRIYSRAFSSVIRFHDKENRANKGGICVANHTSPIDVMVLSCDNCYAMIGQKQAGFLGFLQTTLSRSEHHIWFERGEAGDRAKVMDRMREHVNDENKLPIIIFPEGTCINNTSVMMFKKGSFEIGSTIYPIAVKYDTRLTDAFWNSSAQSYGRYLWSMMTSWAIICDVWYLPAMTRGENEDSISFAKRVKRAIAKKGGLIDLEWDGALKRERVSSKLVTLQQKLYFERLARTTTLNAMLEEKSSDILNIMQGISEEERDELLKQIDEQDDEEEMIRKISSLKPKFKIGDHDADEHIKSD
Protein: DEAD-box ATP-dependent RNA helicase 25 (EC 3.6.4.13) (Q94C75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- Pescadillo homolog
- Ribosome biogenesis protein WDR12 homolog
- AT5g04600/T32M21_200
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Ribosomal protein L1p/L10e family
- Probable rRNA-processing protein EBP2 homolog
- Ribosome assembly factor mrt4
- Transducin/WD40 repeat-like superfamily protein
- KRR1 small subunit processome component
Sequence:
MNSDGPKSGKKRREIRAKLVKKLTSDEDGSGKLVKDNNKSLKRGREGKSDVDEPLIKKPASTTPLVTQIAKTSDSYLSKTRFDQFPLSPLTLKGIEDAGFKTMTVVQEATLPLILQGKDILAKAKTGTGKTVAFLLPSIEAVIKAPPASRDNRHPPIIVLVVCPTRELACQAAAEANILLKYHPSIGVQVVIGGTKLPTEQRRLQKSPCQILVATPGRLKDHIDNTSGFATRLMGVKVLVLDEADHLLDMGFRREIERIIAAVPKQRQTFLFSATVSDEVRQICHVALKRDHEFVNCVQEGAGETHQKVSQMYMIASLDRHFSLLYGLLKKHITDNVGYKVIIFCTTAMVTRLVADLLGKLSLNVREIHSRKPQSYRTRVSDEFRKSKSIILVTSDVSARGVDYPDVSLVVQMGLPSDREQYIHRLGRTGRKGKEGEGVLLLAPWEEYFLSSVKDLPITKSSLPPIDHEAVKKVQKGLIQVEMTNKEAAYQAWLGYYKSQKKIARDTTRLVELANEFSRSMGLSIPPAIPVNILGKMGLKNVPGIRVAPGFDKKPAKRNYRSR