wanglab/gogpt-training-data huggingface dataset:
Protein: ADAM10 endopeptidase (EC 3.4.24.81) (Q9VJW9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Neurogenic locus Notch protein
- Nicastrin
- Presenilin homolog
- Gamma-secretase subunit pen-2
- Furin-like protease 1, isoforms 1/1-X/2
- Protein serrate
- Furin-like protease 2
- Suppressor of hairless protein
- Tissue inhibitor of metalloproteinase
- Tyrosine-protein kinase
Sequence:
MSSKCAFNIVFVSIIFIIIVNGYAKDISGVKRGHERLNEYISHYETLNYDHEHIRASHNRARRSVTKDQYVHLKFASHGRDFHLRLKRDLNTFSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDGRGPRSTSSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQLQQPAISPQQQPQQAFYTPKELPPRNKSRSSRTNNTSNTTTTTNSSTAAAGSGSVSGPGSGAGSSSKSKSGKSAKAKDSKSQKSQQANNSRSSSKEKGVKPVRRNIVY
Protein: Transcription factor JUNGBRUNNEN 1 (NAC domain-containing protein 42) (ANAC042) (Q9SK55)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds to the 5'- RRYGCCGT-3' consensus core sequence. Central longevity regulator. Negative regulator of leaf senescence. Modulates cellular H(2)O(2) levels and enhances tolerance to various abiotic stresses through the regulation of DREB2A.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:22345491}.
Interaction partners:
- Cytochrome P450 71A12
- Thioredoxin superfamily protein
- Dehydration-responsive element-binding protein 2A
- Steroid
Sequence:
MSGEGNLGKDHEEENEAPLPGFRFHPTDEELLGYYLRRKVENKTIKLELIKQIDIYKYDPWDLPRVSSVGEKEWYFFCMRGRKYRNSVRPNRVTGSGFWKATGIDKPVYSNLDCVGLKKSLVYYLGSAGKGTKTDWMMHEFRLPSTTKTDSPAQQAEVWTLCRIFKRVTSQRNPTILPPNRKPVITLTDTCSKTSSLDSDHTSHRTVDSMSHEPPLPQPQNPYWNQHIVGFNQPTYTGNDNNLLMSFWNGNGGDFIGDSASWDELRSVIDGNTKP
Protein: Calcium uniporter protein, mitochondrial (Q08BI9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by micu1 and micu2. At low Ca(2+) levels mcu activity is down-regulated by micu1 and micu2; at higher Ca(2+) levels micu1 increases mcu activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8NE86}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NE86}.
Interaction partners:
- Calcium uptake protein 1, mitochondrial
- Essential MCU regulator, mitochondrial
- Single-pass membrane protein with aspartate-rich tail 1a.
- Calcium uptake protein 3, mitochondrial isoform X1
- Mitochondrial calcium uptake family, member 3a.
- Mitochondrial calcium uniporter regulator 1
- Mitochondrial proton/calcium exchanger protein/H
- BCL-WAV
- Non-selective voltage-gated ion channel VDAC1
- Calcium-transporting ATPase
Sequence:
MAAKVCRSVLLLSRSSGAVASSAYPAFGVSSQRHQGTKTEALSMSLGGHQTVRRAHGLRTGGRCALFCHPSATLTAQGWKGSPSWQVQRLLCSPAAEDVSVVYQNGLPVISVRLPSRRERCQFTLKPLSDTVGVFLQQLQAEDRGIDRVTIYSADGARIASSTGIDILLMDNFKLVINDTSYLVQPPRRDLLPHEDGERLNDVKILVQQLYTTLRIEEHQLNKERELIGRLEDLNSQLQPLEKVKEELSKKAERRTTWVLWGGMAYMATQFGILARLTWWEYSWDIMEPVTYFITYGTAMAMYAYFVLTRQEYLYPDARDRQYLLFFHRGAKRTRFDIEKYNKLKDAIAEAELDLKRLRDPLQLNLPIQQIDTSKD
Protein: Pru domain-containing protein (Q38D00)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- 26S proteasome regulatory subunit 4 homolog
- Proteasome regulatory non-ATP-ase subunit 10
- Proteasome regulatory ATPase subunit 3
- 26S proteasome regulatory subunit RPN3
- Proteasome regulatory ATPase subunit 1
- Proteasome regulatory non-ATP-ase subunit 9
- Proteasome regulatory ATPase subunit 5
- Proteasome regulatory ATPase subunit 6
- Protease regulatory ATPase subunit 4
- Proteasome regulatory non-ATP-ase subunit 2
Sequence:
MKGVGSNNCFIQFRAGKMLLTDGKVVADTRRGTLSFSKESNGVVKMTWVSGSHAEHYDLPLGQVKFSRVDTCTTGRVLLFDFGKAQPPLFFWMQEKSTDNDNTYFSAVENSLVQNPSAIGSLHTHTSPLTDQARARLEGYFASALNNVRGGREQDVDLVSIVGSAKVVDALRADPDYFMCRLHPFLPEGTDSTSGIVEHVINPQVSAAAASLGLVLQTPDGFRELCAAFHVDGKKTGVVGFISGLLKQVKK
Protein: Chitinase-like protein Idgf4 (Imaginal disk growth factor protein 4) (Q9W303)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex.
Subcellular location: Secreted {ECO:0000269|PubMed:9847235}. Note=Secreted in hemolymph. It is probably transported to target tissues via hemolymph.
Interaction partners:
Sequence:
MKLYALFSLLVGSLAIGQISAAGSHHLLCYYDGNSFVREGLSKLILTDLEPALQYCTHLVYGYAGINPSSNKLVSNNEKLDLDLGSSLFRQVTGLKRKYPALKVLLSVGGDKDTVDPENNKYLTLLESSNARIPFINSAHSLVKTYGFDGLDLGWQFPKNKPKKVHGSIGKFWKGFKKIFSGDHVVDEKAEEHKEAFTALVRELKNAFRPDGYILGLSVLPNVNSSLFFDVPAIINNLDYVNLHTYDFQTPERNNEVADFPAPIYELNERNPEFNVNYQVKYWTGNRAPAAKINVGIATYGRAWKLTKDSGLTGLPPVAEADGVAPAGTQTQIPGLLSWPEVCAKLPNPANQHLKGADGPLRKVGDPTKRFGSYAYRSADDSGENGVWVGYEDPDTAAIKAEYVKREGLGGIAVVDLSFDDFRGGCTGHDKFPILRQVKSKL
Protein: Lysozyme-like protein 6 (EC 3.2.1.17) (O75951)
Organism: Homo sapiens (Human)
Function: May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6.
Subcellular location: Secreted {ECO:0000269|PubMed:28182716}. Cell surface {ECO:0000269|PubMed:28182716}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9DA11}. Note=Detected on the postacrosomal membrane of mature spermatozoa (PubMed:28182716). {ECO:0000269|PubMed:28182716}.
Interaction partners:
Sequence:
MTKALLIYLVSSFLALNQASLISRCDLAQVLQLEDLDGFEGYSLSDWLCLAFVESKFNISKINENADGSFDYGLFQINSHYWCNDYKSYSENLCHVDCQDLLNPNLLAGIHCAKRIVSGARGMNNWVEWRLHCSGRPLFYWLTGCRLR
Protein: Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82) (Q01134)
Organism: Rattus norvegicus (Rat)
Function: Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis. Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis. Has higher activity with choline. May contribute to tumor cell growth.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P35790}.; SUBCELLULAR LOCATION: [Isoform 1]: Lipid droplet {ECO:0000250|UniProtKB:P35790}. Note=Isoform 1 localizes to lipid droplets following phosphorylation by AMPK. {ECO:0000250|UniProtKB:P35790}.
Interaction partners:
- Ethanolamine-phosphate cytidylyltransferase
- Choline-phosphate cytidylyltransferase A
- Choline-phosphate cytidylyltransferase B
- Ethanolamine-phosphate phospho-lyase
- Glycerophosphocholine phosphodiesterase GPCPD1
- Choline/ethanolamine kinase
- Phosphoethanolamine/phosphocholine phosphatase
- Choline O-acetyltransferase
- Acetylcholinesterase
- Choline/ethanolaminephosphotransferase 1
Sequence:
MKTKFCTGGEAEPSPLGLLLSCGGSAAPTPGVGQQRDAAGELESKQLGGRSQPLALPPPPPPPLPLPPPPSPPLADEQPEPRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDSIASVGDEPRKVLLRLYGAILKMRSCNKEGSEQAQNENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELCLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLNQVLRLKFSREARVQQLHKFLSYNLPLELENLRSLLQYTRSPVVFCHNDCQEGNILLLEGQENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFRANIQKYPTRKQQLHFISSYLTTFQNDFESLSSEEQSATKEDMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMEYAQARFDAYFDQKRKLGV
Protein: Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) (Q6UXT9)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Sequence:
MPPWGAALALILAVLALLGLLGPRLRGPWGRAVGERTLPGAQDRDDGEEADGGGPADQFSDGREPLPGGCSLVCKPSALAQCLLRALRRSEALEAGPRSWFSGPHLQTLCHFVLPVAPGPELAREYLQLADDGLVALDWVVGPCVRGRRITSAGGLPAVLLVIPNAWGRLTRNVLGLCLLALERGYYPVIFHRRGHHGCPLVSPRLQPFGDPSDLKEAVTYIRFRHPAAPLFAVSEGSGSALLLSYLGECGSSSYVTGAACISPVLRCREWFEAGLPWPYERGFLLHQKIALSRYATALEDTVDTSRLFRSRSLREFEEALFCHTKSFPISWDTYWDRNDPLRDVDEAAVPVLCICSADDPVCGPPDHTLTTELFHSNPYFFLLLSRHGGHCGFLRQEPLPAWSHEVILESFRALTEFFRTEERIKGLSRHRASFLGGRRRGGALQRREVSSSSNLEEIFNWKRSYTR
Protein: Chromosome 11 open reading frame 54 (E9PIP1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MACAEFSFHVPSLEELAGVMQKGLKDNFADVQVSVVDCPDLTKEPFTFPVKGICGKTRIAEVGGVPYLLPLVNQKKVYDLNKIAKEIKLPGAFILGAGAGPFQTLGFNSEFMPVIQTESEHKPPVNGSYFAHVNPADGGCLLEKYSEKCHDFQCALLANLFASEGQPGKVI
Protein: Serine/threonine-protein kinase KIN4 (EC 2.7.11.1) (Q01919)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: This protein is probably a serine/threonine protein kinase.
Interaction partners:
- Mitotic check point protein BFA1
- Guanine nucleotide exchange factor LTE1
- Mitotic check point protein BUB2
- Protein TEM1
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
- Karyogamy protein KAR9
- Gamma tubulin complex adapter SPC72
- Sporulation-specific protein 12
- Protein NUD1
- Tyrosine-protein phosphatase CDC14
Sequence:
MASVPKRHTYGGNVVTDRDRHSLQRNNEILHPIHKNQRKHATFGPYIIGSTLGEGEFGKVKLGWTKASSSNEVPKQVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACRLFAQLISGVNYMHYKGLVHRDLKLENLLLDKHENLVITDFGFVNEFFEDNELMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILYAMLAGYLPWDDDHENPTGDDIARLYKYITQTPLKFPEYITPIPRDLLRRILVPNPRRRINLQTIKRHVWLKPHEAFLSIQPNYWDEHLQKERPKPPNKGDVGRHSTYSSSASSYSKSRDRNSLIIESTLEQHRMSPQLATSRPASPTFSTGSKVVLNDTKNDMKESNINGERTSASCRYTRDSKGNGQTQIEQVSARHSSRGNKHTSVAGLVTIPGSPTTARTRNAPSSKLTEHVKDSSQTSFTQEEFHRIGNYHVPRSRPRPTSYYPGLSRNTADNSLADIPVNKLGSNGRLTDAKDPVPLNAIHDTNKATISNNSIMLLSEGPAAKTSPVDYHYAIGDLNHGDKPITEVIDKINKDLTHKAAENGFPRESIDPESTSTILVTKEPTNSTDEDHVESQLENVGHSSNKSDASSDKDSKKIYEKKRFSFMSLYSSLNGSRSTVESRTSKGNAPPVSSRNPSGQSNRSNIKITQQQPRNLSDRVPNPDKKINDNRIRDNAPSYAESENPGRSVRASVMVSTLREENRSELSNEGNNVEAQTSTARKVLNFFKRRSMRV
Protein: DNA mismatch repair proteins mutS family domain-containing protein (Q9TXR4)
Organism: Caenorhabditis elegans
Interaction partners:
- DNA mismatch repair protein S5 domain-containing protein
- DNA mismatch repair protein
- Mismatch repair endonuclease PMS2
- Exonuclease 1
- ERCC1-like central domain-containing protein
- XPA C-terminal domain-containing protein
- DNA repair endonuclease XPF
- Proliferating cell nuclear antigen
- DNA repair protein RAD51 homolog
- Flap endonuclease 1
Sequence:
MSGGKDEASDKALLKILKSKSPNTIAIFSRGEYFSVYGDDATFVATNIFKSDVCVKTFTLSTDNSQQMKYISVNRGQYEKVVRETIVLLRCSVELYSSEQGEWKMTKRGSPGNTVDFEQEIGVSDQAPILAIYIHPGDDDNRVTLCAWDAGNVRIVISEYIDTPSFSQTEQCIFGLCPTEYILVNEGSVAPKAKKIASMFTRMEVHNKQQLKPKSQWSDVIESVHLDYKDEAEKQNENIKECLQILHSNAADEYSISEKYSIFNYGTHGNMLIDSCAVEALELFQLNYNYLEKSNNLTLYNVLNKCKTLPGEKLLRDWLSRPLCQIDHINERLDIVEALFENQTIRQKLRDSILARMPDCSQLARRLMRKCTLQDLNRFYQAATLLETVEMQLIQLSEAEQFAPSINRLLKSEITEILKKVERFQVLCDEFFDFDYEKENKEIRVRVDFVPEIQEISEKLEQMERVAEKLRKKYSAKFECDNLKLDKNSQYGFYFRVTLKEEKSIRKKDVHILETTKGSGVKFSVGELSDINDEFLEFHLKYTRAEEEVISMLCKKAEEFIPLIPAMAQLIATLDVFVSLSTFAATSSGIYTRPNLLPLGSKRLELKQCRHPVIEGNSEKPFIPNDVVLDKCRLIILTGANMGGKSTYLRSAALSILLAQIGSFVPCSSATISVVDGIFTRVGASDKQSQGISTFMAEMLDCSAILQRATKNSFVVIDELGRGTSTFDGFGIASAIAQDILNRIQCLSIFATHFHEMGKLAEQPGAVALQMGVQIENNEIHMLYKVFEGVAQCSFGLQVAKMVGIDENVINKAAQLLEGLEKKLVIDSKKKKELLESADIRQAILSLVK
Protein: Inactive leucine-rich repeat receptor-like serine/threonine-protein kinase At5g24100 (Q9FL63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MSRGRSFIFYFVLFLFFGSSALYSQVTGDLAGDRQALLDFLNNIIHPRSLAWNTSSPVCTTWPGVTCDIDGTRVTALHLPGASLLGVIPPGTISRLSELQILSLRSNGLRGPFPIDFLQLKKLKAISLGNNRFSGPLPSDYATWTNLTVLDLYSNRFNGSIPAGFANLTGLVSLNLAKNSFSGEIPDLNLPGLRRLNFSNNNLTGSIPNSLKRFGNSAFSGNNLVFENAPPPAVVSFKEQKKNGIYISEPAILGIAISVCFVIFFVIAVVIIVCYVKRQRKSETEPKPDKLKLAKKMPSEKEVSKLGKEKNIEDMEDKSEINKVMFFEGSNLAFNLEDLLIASAEFLGKGVFGMTYKAVLEDSKVIAVKRLKDIVVSRKDFKHQMEIVGNIKHENVAPLRAYVCSKEEKLMVYDYDSNGSLSLRLHGKNADEGHVPLNWETRLRFMIGVAKGLGHIHTQNLAHGNIKSSNVFMNSEGYGCISEAGLPLLTNPVVRADSSARSVLRYRAPEVTDTRRSTPESDIYSFGILMLETLTGRSIMDDRKEGIDLVVWVNDVISKQWTGEVFDLELVKTPNVEAKLLQMLQLGTSCTAMVPAKRPDMVKVVETLEEIERD
Protein: Probable transport accessory protein MmpS2 (P9WJT3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable transport protein MmpL2
- Uncharacterized protein Rv0508
Sequence:
MISVSGAVKRMWLLLAIVVVAVVGGLGIYRLHSIFGVHEQPTVMVKPDFDVPLFNPKRVTYEVFGPAKTAKIAYLDPDARVHRLDSVSLPWSVTVETTLPAVSVNLMAQSNADVISCRIIVNGAVKDERSETSPRALTSCQVSSG
Protein: UPF0538 protein C2C4.04c (O14037)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MTGATLTVRVIRNFEYRTLKNVVFHDIDLATTTVDQFKKIIDERIQTDPSLKIYRTTHFDTLKIYVKAQQHKTQNLAINLDHDDWILNDGAKTLSLCGIENETELSYFELAAYKAYQANPVQKWL
Protein: Envelope glycoprotein N (F5HFQ0)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Also plays a critical role in virion morphogenesis.
Subcellular location: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04037, ECO:0000269|PubMed:12771417}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04037, ECO:0000269|PubMed:12771417}. Host membrane {ECO:0000255|HAMAP-Rule:MF_04037}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04037, ECO:0000269|PubMed:12771417}. Host Golgi apparatus, host trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04037}. Note=When coexpressed with gM, localizes in the host trans-Golgi network. {ECO:0000255|HAMAP-Rule:MF_04037}.
Interaction partners:
Sequence:
MTASTVALALFVASILGHCWVTANSTGVASSTERSSPSTAGLSARPSPGPTSVTTPGFYDVACSADSFSPSLSSFSSVWALINALLVVVATFFYLVYLCFFKFVDEVVHA
Protein: Villin-like protein (O15195)
Organism: Homo sapiens (Human)
Function: Possible tumor suppressor.
Interaction partners:
Sequence:
MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKRLPEEVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAASEWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSSSVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF
Protein: Vacuolar fusion protein CCZ1 homolog (Q9XVL8)
Organism: Caenorhabditis elegans
Interaction partners:
- Vacuolar fusion protein MON1 homolog
- Vacuolar protein sorting-associated protein 39 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting-associated protein 16 homolog
- Ras-related protein Rab-7a
- Vacuolar protein sorting-associated protein 41 homolog
- small monomeric GTPase
- Vacuolar protein sorting-associated protein 33A
- Vacuolar protein sorting-associated protein 33B
Sequence:
MESIANPLYFFSNLSLNPPSCSNVVRFIDVLEFFFVAHPLSGRKEGEEHNRVMYFHPKGEQLERQTEITGFAEAVVNFTENFLSTSRREISERISENEDGFDFRTVTTQRTEHVYIRTEDDQFILGVSISKQLSLVSDYPLFQPAIRSILSDAYKMFRMFFGTFSSFIKNVPDDIPKFKERLDFFFSKYIPLLKVHKMPLLDHLGGVEFLRMSGPLYLNVVSLLSELREEFQVIEKIMFLYQDKLLYYQLSKRDLPSLFHYLTHNLLPTTLAPELEHSGRNASKGRYLRGPTDLTTDAPLLGDESLSVVHLHSDQGTEFQEELIGYQMIVYRCLNATVCMFVRNCPANGGLEIRRDSESSQSSRATPSQNGVVSRRLLRNIDQFLETELSQVASKIGDEIGDEKFPEAPDFHYIYFNPSSLSMTSSLSTSPKLPVAASGSNSTLKVPLPPVDVNRLVCDTMSNFVSETEEFGECFVKSSSDWWIVIKKVNSRLLVLIIPPSNYTSSLADVQSKTATIVRSHFEAIFFS
Protein: Chloride channel protein (Q8LPA1)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
Interaction partners:
Sequence:
SGSAGEPLLRKRTMNTTSQIAIVGANVCPIESLDYEVVENDLFKQDWRSRKKKQIFQYIVLKWTLVLLIGLLTGLVGFFNNLAVENIAGFKLLLTGNLMLKGKCRYLTAFFAYGGCNLVLAAAAAAICAYIAPAAAGSGIPEVKAYLNGVDAYSILAPSTLFVKIFGSILGVSAGFVLGKEGPMVHTGACIANLLGQGGSRKYRLTCNWLRYFKNDRDRRDLITCGSAAGVAAAFRAPVGGVLFALEEAASWWRSALLWRAFFTTAVVAVVLRSLIEFCRSGKCGLFGQGGLIMFDLSSTVATYSTPDLIAIIILGIIGGIFGGLFNFLLDKVLRVYSIINERGAPFKILLTITISIITSMCSYGLPWLAACTPCPVDAVEQCPTIGRSGNFKNFQCPPGHYNDLASLFFNTNDDAIRNLFSNGTESEFHMSTLFIFFTAVYCLGILTYGVAVPSGLFIPVILAGATYGRIVGTLLGSISDLDPGLFALLGAASFLGGTMRMTVSVCVILLELTNDLAMLPLVMLVLLISKTIADNFNKGVYDQIVVMKGLPYMEAHAEPYMRHLVAGDVVSGPLITFSGVEKVGNIVHALRFTGHNGFPVVDEPPLTEAPELVGLVTRSHLLVLLNGKMFMKDQLKTSGSFVLQRFGAFDFAKPGSGKGLKIQDLDFTDEEMEMYVDLHPVTNTSPYTVVETMSLAKAAILFRALGLRHLLVVPKTPDRPPIVGILTRHDFVEEHIHGLFPNLNPHKFHSTSMGG
Protein: Phosducin-like protein (PHLP) (Q9DBX2)
Organism: Mus musculus (Mouse)
Function: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:29290584}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- T-complex protein 1 subunit eta
- Guanine nucleotide-binding protein G
- T-complex protein 1 subunit epsilon
- Guanine nucleotide-binding protein G
- T-complex protein 1 subunit gamma
Sequence:
MTTLDDKLLGEKLQYYYSTSEDEDSDHEDKDRGRGAPAISSTPAEAELAGEGISINTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMSCRSHLDEEEEQQKQKDLQEKISGKMTLKEFGTKDKNLDDEEFLQQYRKQRMEEMRQQFHKGPQFKQVFEIPSGEGFLDMIDKEQKSTLIMVHIYEDGVPGTEAMNGCMICLATEYPAVKFCRVRSSVIGASSRFTRNALPALLIYKAGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID
Protein: Allergen dI chain C2D (Q7M745)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKGTLLLLALLVIGELGFQTTEACLSLARTYGAILTLRRTFLHGDLSQFYATVAERVAFEKIQECFREEGQKTIILNPQIMLSLYLSPECKKYYGNDLLKKIQDFLNQSNIH
Protein: RNA-binding protein Nova-2 (Astrocytic NOVA1-like RNA-binding protein) (Neuro-oncological ventral antigen 2) (Q9UNW9)
Organism: Homo sapiens (Human)
Function: Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons. Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Uniquely regulates alternative splicing events of a series of axon guidance related genes during cortical development, being essential for central nervous system development by regulating neural networks wiring. Regulates differentially alternative splicing on the same transcripts expressed in different neurons. This includes functional differences in transcripts expressed in cortical and cerebellar excitatory versus inhibitory neurons where is required for, respectively, development of laminar structure and motor coordination and synapse formation. Also the regulation the regulation of intron retention can sequester the trans-acting splicing factor PTBP2, acting as a variable cis-acting scaffolding platform for PTBP2 across various natural conditions (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:A0A1W2P872}.
Interaction partners:
- Polypyrimidine tract-binding protein 2
- Protein FAM107B
- RNA-binding protein Nova-1
- Heterogeneous nuclear ribonucleoproteins C1/C2
- Voltage-gated potassium channel regulatory subunit KCNF1
- Sodium channel protein type 1 subunit alpha
Sequence:
MEPEAPDSRKRPLETPPEVVCTKRSNTGEEGEYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLVQGTAEALNAVHSFIAEKVREIPQAMTKPEVVNILQPQTTMNPDRAKQAKLIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGINLQERVVTVSGEPEQVHKAVSAIVQKVQEDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAFPAALPAFSGTDLLAISTALNTLASYGYNTNSLGLGLNSAAASGVLAAVAAGANPAAAAAANLLASYAGEAGAGPAGGAAPPPPPPPGALGSFALAAAANGYLGAGAGGGAGGGGGPLVAAAAAAGAAGGFLTAEKLAAESAKELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFLPGTRNRRVTITGSPAATQAAQYLISQRVTYEQGVRASNPQKVG
Protein: Cyclin-G2 (O08918)
Organism: Mus musculus (Mouse)
Function: May play a role in growth regulation and in negative regulation of cell cycle progression.
Subcellular location: Cytoplasm. Nucleus. Note=Primarily found in the cytoplasm. A minor portion can be detected in some cells in the nucleus.
Interaction partners:
- Cyclin-G1
- E3 ubiquitin-protein ligase Mdm2
Sequence:
MKDLGAKHLAGGEGVQLFGLLNFYLEQEQRYQPREKGLILMEATPENDNTLCSRLRNAKVEDLRSLTNFFGSGTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLAEEEGDVPPTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHLYHAIVFCHTSERKEILSLDKLEAQLKACNCRVVFSKARPSVLALCLLNLEIETIKSVELLEILLLVKKHLKLSDTEFFYWRELVSKCLAEYSSPRCCKPDLKKLVWIVSRRTAQNLHSSYYSVPELPTIPEGGCFDGSESEDSGEDMSCGEESLSSSPPSDQECTFFFDFQVAQTLCFPP
Protein: Expressed protein (O80780)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MPPGAKKRKALKKKQQEQEATGVATNNKGFNGHGHDEHGSQDERDSDGNLSSPGSQGNEEFGTRDPSPPPLSSLGKDIVKEKAEDADFTGGQVAKGEDVIEVGRGRTDHEENGVNKQLNSCPENFTQTSREADSTSSLEISPALDSVKPMGSSVSKVVMSDKSKQVESSTDSDSLQQKSDEKEEILSPRSAEETNKEIKNVKEYEVPECSKEKSLLPSGPPVFRTSWLSCCGLFDVMAGSER
Protein: Probable G-protein coupled receptor 21 (Q8BX79)
Organism: Mus musculus (Mouse)
Function: Orphan receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MNSTWDGNQSSHPFCLLALGYLETVRFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLNHHSTSYFIQTMAYADLLVGVSCLVPSLSLLYYPLPIEEAMTCQVFGFVVSVLKSISMASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQWCAESWHTNSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKEISERQARFSSQNGETGEPQTCPDKRYAMVLFRITSVFYVLWLPYIIYFLLESSTGCSSRLASFLTTWLAISNSFCNCIIYSLSNSVFQRGLKGLSGSLCTSCASHTTAKDPYTVRCKGPPNGSHI