wanglab/gogpt-training-data huggingface dataset:
Protein: Megakaryocyte and platelet inhibitory receptor G6b (ITIM-receptor G6b-B) (Immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing platelet receptor) (D7PDD4)
Organism: Mus musculus (Mouse)
Function: Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (By similarity). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner (By similarity).
Subcellular location: Cell membrane {ECO:0000305|PubMed:23112346}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O95866, ECO:0000255}.
Interaction partners:
- Tyrosine-protein phosphatase non-receptor type 11
- Platelet glycoprotein VI
- Tyrosine-protein phosphatase non-receptor type 6
- C-type lectin domain family 1 member B
Sequence:
MALVLPLLPLLLSKVQGNPEVSLEGSPGDRVNLSCIGVSDPTRWAWAPSFPACKGLSKGRRPILWASTRGTPTVLQHFSGRLRSLDNGIKRLELLLSAGDSGTFFCKGRHENESRTVLQVLGDKAGCRPAGSTHGYEYPKVLIPLLGVGLVLGLGVAGVVWRRRRLSPPPPPPPPPGPLPTFAPVINAEPQRPLEQESKISGHLDQEPSLHYADLDHSVLGRHRRMSTVVSGDASTVYAVVV
Protein: Histone deacetylase 4 (HD4) (EC 3.5.1.98) (P56524)
Organism: Homo sapiens (Human)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q6NZM9}.
Interaction partners:
- Nuclear receptor corepressor 2
- Nuclear receptor corepressor 1
- Runt-related transcription factor 2
- Ankyrin repeat family A protein 2
- 14-3-3 protein gamma
- Myocyte-specific enhancer factor 2C
- Heat shock protein HSP 90-alpha
- Myocyte-specific enhancer factor 2A
- Histone deacetylase 5
- B-cell lymphoma 6 protein
Sequence:
MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL
Protein: Alpha-1-antitrypsin 1-1 (AAT) (Alpha-1 protease inhibitor 1) (Alpha-1-antiproteinase) (Serine protease inhibitor 1-1) (Serine protease inhibitor A1a) (Serpin A1a) (P07758)
Organism: Mus musculus (Mouse)
Function: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
Subcellular location: Secreted {ECO:0000269|PubMed:11961105, ECO:0000269|PubMed:8619829}.
Interaction partners:
- Albumin
- Neutrophil elastase
- Alpha-1-antitrypsin 1-2
- Vitamin K-dependent protein C
- Alpha-1-antitrypsin 1-3
- Alpha-1-antitrypsin 1-4
- Fibrinogen alpha chain
- Pregnancy zone protein
- Fibrinogen beta chain
- Alpha-2-HS-glycoprotein
Sequence:
MTPSISWGLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDESTTVKVPMMTLSGMLHVHHCSTLSSWVLLMDYAGNATAVFLLPDDGKMQHLEQTLSKELISKFLLNRRRRLAQIHFPRLSISGEYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTIDETGTEAAAVTVLQMVPMSMPPILRFDHPFLFIIFEEHTQSPIFLGKVVDPTHK
Protein: Mas-related G-protein coupled receptor member B5 (Q7TN44)
Organism: Rattus norvegicus (Rat)
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MPDSPTESYGPDREYHVFISLFLCRNTSGKFLSVGPATPGWSINNTVVKENYYTEKLSCIITFNTLNFLTATISVVGTAGNATVLRLLGFHMHRYAFSVYVFNLAGADFLYLCTQTVYSLECVLQFDNSYFYFLLTILMFAYLAALCMIPAISTERCLSVTWPIWYHCQRPRHTSATVCALFWAFSLLLRLLLGQGCGFLFGKYDYYFCRYCSFITTAFLIVLFVVPFVSSLAMLTKIICGSHRIPVTRFYVTIAVTVLVFTFFGLPVGIISLLLPRIVVFRGVFYIYKIVTFLYSVNCCANPIIYFLIGSIRHHRLQRQSLKLLLQRAMQDTPEEEGGVKGPSQKSNELEIV
Protein: Alpha-2-HS-glycoprotein (Fetuin-A) (B0JYN6)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKSFVLLFCLAQLWGCHSIPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPLANCSVRQQTQHAVEGDCDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVSVSVEFAVAATDCIAKEVVDPTKCNLLAEKQYGFCKGSVIQKALGGEDVRVTCTLFQTQPVIPQPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI
Protein: Recombination protein RecR (P0A7H6)
Organism: Escherichia coli (strain K12)
Function: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
Interaction partners:
- DNA repair protein RecO
- Nucleoid-associated protein YbaB
- DNA replication and repair protein RecF
- DNA polymerase III subunit tau
- Single-stranded-DNA-specific exonuclease RecJ
- Protein RecA
- DNA repair protein RecN
- DNA helicase II
- ATP-dependent DNA helicase RecG
- ATP-dependent DNA helicase RecQ
Sequence:
MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQEVCNICSNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLAEEKITEVILATNPTVEGEATANYIAELCAQYDVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIRF
Protein: Retrotransposon hot spot (RHS) protein, putative (Q585H2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSRANSPAAPQGNNENPQVAGNFGAAMRRPRDENVPPPAAQPPQIRQRTEGGPNWTMDSKVRDVLLEDYAGLRDMTVNDFIQKFVGGTFAVAEAENVRMPIFVQSPEDYILDARLLGRVRGTDEFKTVKTAIDLSEKVDYLDEKEISTLSQWEEKGKGEIREFVGPVARGRLDAAVIAAKRAEKRAAQASDGAVYLEGVYDSIYNAKWSYVMSGYDEEPLGMKVFDGRPPHMWTEEEVDINPLPANLDARVPERPYGLEIFVLTSEKGWPYNRFALDDAEICWENFKHVYIRREIMRVWYIIQRGLQGRWVEKADITPRHIVIGTPGIGKSYGVGSFLLHSLLHFHEGMFDVVAYFTDGIAYLIYNKKPGEEGRVEEYEDVKAAVRVIAALVFKKKKGHIIVDICKNAQTPPDGLPVHAWGVTLLTSPDEAHFHHWSKDKRDVGIIINCDDVRDMKAFVAWTKLSVASGYAALDEEAQARIVEELENEWETIKSRINVVGPVPRCVYNSAGYTKRVSQAKKMITSINGDNKSHYEDIMGKIADWRNDKVTHRLVKIVRVRDAGESVDEYRCRPLSVCIGNAIFFKLLAIDVEKMAICQVTMSDESAAANVFESRALLSLLFPRVFKVIAENLKYLQRPGGLEEKRCILNDMAPQQLRLIGQKALPATHQQPIDNCEYMVLYRPATGNEPVVDGFFFVEGRFRRNRDGAAPPTTPNIAVLLQVTKSERHPTTTDKVKKFRENMARYFSDWGAFSRNMVWEMIYINSVNGGVITRWQLCDGDNPAEAADMWRNMAQYQVTLREEMQGQLMRAYRDECWYRDAPLLAMEPAPQPRNEQAGAQGG
Protein: S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase, chloroplastic (Urophorphyrin III methylase) (EC 2.1.1.107) (Urophorphyrin methylase 1) (AtUPM1) (Q42606)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required for siroheme biosynthesis. Catalyzes the two successive C-2 and C-7 methylation reactions involved in the conversion of uroporphyrinogen III to precorrin-2 via the intermediate formation of precorrin-1. It is a step in the biosynthesis of siroheme. Promotes nitrogen and sulfur assimilation as well as photosynthesis efficiency by triggering chlorophyll, nitrite reductase (NiR) and sulfite reductase (SiR) biosynthesis.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:9006913}.
Interaction partners:
- Porphobilinogen deaminase, chloroplastic
- Ferredoxin--nitrite reductase, chloroplastic
- Sirohydrochlorin ferrochelatase, chloroplastic
- Uroporphyrinogen decarboxylase 1, chloroplastic
- Uroporphyrinogen decarboxylase 2, chloroplastic
- Assimilatory sulfite reductase
- Uroporphyrinogen-III synthase, chloroplastic
- 5'-adenylylsulfate reductase 1, chloroplastic
- Rieske
- 5'-adenylylsulfate reductase 3, chloroplastic
Sequence:
MALVQRIPISSSSIRNWQQARTNLTPICCLHYNTASSSSSPFTEKHSVERYQRDQWLYKAVEPTPPSTPSPSPFEDEVFVRENDIASQLPELKKLLAVLKEKRVKGCKGGDCGPGDVYLVGTGPGDPELLTLKAVRVIQSADLLLYDRLVSNDVLELVAPDARLLYVGKTAGYHSRTQEEIHELLLNFAEAGATVVRLKGGDPLVFGRGGEEMDFLQQQGIRVQVIPGITAASGIAAELGIPLTHRGVATSVRFLTGHSRKGGTDPLFVAENAADPDTTLVVYMGLGTLPSLAQKLMDHGLPSDTPAVAVERGTTPLQRTVFAELKDFATEIQSAGLVSPTLIIIGKVVELSPLWPHCTKESSCLVETR
Protein: Mitosis inducer protein kinase cdr1 (EC 2.7.11.1) (Protein kinase nim1) (P07334)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: This protein, a dose-dependent mitotic inducer, appears to function as a negative regulator of mitosis inhibitor wee1 by phosphorylating and inactivating it.
Interaction partners:
- Mitosis inhibitor protein kinase wee1
- M-phase inducer phosphatase
- Mitosis inducer protein kinase cdr2
- Mitosis inducer protein blt1
- Mitosis inhibitor nif1
- Protein arginine N-methyltransferase skb1
- Cyclin-dependent kinase 1
- Anillin-related medial ring protein mid1
- Rho guanine nucleotide exchange factor gef2
- Kinesin-like protein 8
Sequence:
MVKRHKNTIGVWRLGKTLGTGSTSCVRLAKHAKTGDLAAIKIIPIRYASIGMEILMMRLLRHPNILRLYDVWTDHQHMYLALEYVPDGELFHYIRKHGPLSEREAAHYLSQILDAVAHCHRFRFRHRDLKLENILIKVNEQQIKIADFGMATVEPNDSCLENYCGSLHYLAPEIVSHKPYRGAPADVWSCGVILYSLLSNKLPFGGQNTDVIYNKIRHGAYDLPSSISSAAQDLLHRMLDVNPSTRITIPEVFSHPFLMGCTSLSSMDSTTPPTPSLSIDEIDPLVVDCMCVLWKKSSSKKVVRRLQQRDDNDEKYVYKVLSEILRDDMLKKQRFDENKYLSLYDLIHDNNLFTKASISTTSLVKSNVSTNSRKSSNFEDELARRVSSPLSALNQMSQSPIPIRVSSDKDYDSYACHEVVSNPSTLDDDYNYMFVCPPEEYTYSTDNVRTDSLDLQSLPTPTLEQLESVPFNRYGYVRIFPSTTLSSTASGYYTPDSLSTPEPSIDGLTNLDDVQVGGFVQGSGNQNRRPISFPVISNMQPNITNVRSASAPLCSSPVPSRRYSQYATNARYTPRKVSSGSVLRKISSFFRKD
Protein: Aldo-keto reductase family 1, member B8 (A0A8I5ZN93)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAFVKLSTKAKMPIVGLGTWKSPPDKVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWPTFFEKSLVKKAFQKTLLDLKLDYLDLYLIHWPQGFQSGNVFLPTDDKGNVLTSKYTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGIVVTAYSPLGSPDRPSAKPEDPVLLEIPKIKEIASKHKKTAAQVLIRFHIERNVAVIPKSVTPSRIQENIQVFDFQLSEEDMAAILSFNRNWRACGLFA
Protein: AUGMIN subunit 6 (Q94BP7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Contributes to the assembly of the acentrosomal spindle and phragmoplast microtubule arrays as part of the augmin complex.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22505726}. Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:22505726}. Note=Preferentially localizes to microtubules minus ends. {ECO:0000269|PubMed:22505726}.
Interaction partners:
- AUGMIN subunit 3
- Guanine nucleotide-binding protein subunit beta
- AUGMIN subunit 1
- AUGMIN subunit 4
- AUGMIN subunit 7
- AUGMIN subunit 5
- AUGMIN subunit 8
- AUGMIN subunit 2
- HAUS augmin-like complex subunit
- Extra-large guanine nucleotide-binding protein 1
Sequence:
MTMDREKERELELESAMYTNCLLLGLDPNVIGLGASNGTPRVGLFRHSNPKLGEQLLYFILSSLRGPAQSSKDFDKVWPIFDSAQSRDFRKVVQAIISELESQGALPRSNSRVSSLATCCGPRFVELLWQLSLHALREVHRRTFPADVASNPLPSSLTDVSFSHAATLLPVTKARIVLERRRFLKNAETAVQRQAMWSNLAHEMTAEFRGLCAEEAYLQQELEKLNDLRNKVKQEGEVWDDLVSSSSQNSHLVSKATRLWDSIMARKGQHEVLASGPIEDLIAHREHRYRISGSALLAAMDQSSQVPRAELLSAHSDDSASLADDKELSDGSYTNMHDHSLVDSFETASSQASDETLSRVDDRGGKINQTVDVAEVIRRWTHALQRIHKQSLLLAKANDGDGPDILRTASDGGTSGHVESLAATLTEHQQHLASFQVLINQLKEVSPAIQKSISECTEMVNSLPPTLPPVTRSNGQASSLLQSQGSGRIMEGVSNDVAELTSTMSNVQLEKVSASPTLKLPQLFSSTPTSSGKGGNGQKRQTMASQVNKMESLSEKNSTDQALSNARPDNLPTDTSSSFVHNLKKSVREAALLIPSSAGSSRDSQSDEGSEHYFVPLSATGFSRFPSETKALPLRGSRALTSLSEPSFLEPNVPDSFAPSKYSDIPDTYDDLDSFKDYDNGNGFLSVAGSNSVASDAQQSFYDIDDQVFSPPLLMDSSLLSDAYEDLLAPLSETEAALMEH
Protein: Non-structural protein V (P11207)
Organism: Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5)
Function: Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Efficiently blocks type I IFN signaling following infection by behaving as a substrate receptor for CUL4-DDB1 E3 ligase complex and targeting host STAT1 for proteasomal degradation.
Subcellular location: Host cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MDPTDLSFSPDEINKLIETGLNTVEYFTSQQVTGTSSLGKNTIPPGVTGLLTNAAEAKIQESTNHQKGSVGGGAKPKKPRPKIAIVPADDKTVPGKPIPNPLLGLDSTPSTQTVLDLSGKTLPSGSYKGVKLAKFGKENLMTRFIEEPRENPIATSSPIDFKRGRDTGGFHRREYSIGWVGDEVKVTEWCNPSCSPITAAARRFECTCHQCPVTCSECERDT
Protein: Lymphocyte antigen 6E (Ly-6E) (Stem cell antigen 2) (Thymic shared antigen 1) (TSA-1) (Q64253)
Organism: Mus musculus (Mouse)
Function: GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion. Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9575182}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Lymphocyte antigen 6A-2/6E-1
Sequence:
MSATSNMRVFLPVLLAALLGMEQVHSLMCFSCTDQKNNINCLWPVSCQEKDHYCITLSAAAGFGNVNLGYTLNKGCSPICPSENVNLNLGVASVNSYCCQSSFCNFSAAGLGLRASIPLLGLGLLLSLLALLQLSP
Protein: Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) (Q9Y512)
Organism: Homo sapiens (Human)
Function: Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:15644312}; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q6AXV4}. Mitochondrion {ECO:0000269|PubMed:25781180}.
Interaction partners:
- MICOS complex subunit MIC19
- Mitochondrial import receptor subunit TOM40 homolog
- MICOS complex subunit MIC60
- Metaxin-2
- Metaxin-1
- Mitochondrial import receptor subunit TOM22 homolog
- Metaxin-3
- DnaJ homolog subfamily C member 11
- MICOS complex subunit MIC25
- MICOS complex subunit MIC10
Sequence:
MGTVHARSLEPLPSSGPDFGGLGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIICEIGDVFKAKNLIEVMRKSHEAREKLLRLGIFRQVDVLIDTCQGDDALPNGLDVTFEVTELRRLTGSYNTMVGNNEGSMVLGLKLPNLLGRAEKVTFQFSYGTKETSYGLSFFKPRPGNFERNFSVNLYKVTGQFPWSSLRETDRGMSAEYSFPIWKTSHTVKWEGVWRELGCLSRTASFAVRKESGHSLKSSLSHAMVIDSRNSSILPRRGALLKVNQELAGYTGGDVSFIKEDFELQLNKQLIFDSVFSASFWGGMLVPIGDKPSSIADRFYLGGPTSIRGFSMHSIGPQSEGDYLGGEAYWAGGLHLYTPLPFRPGQGGFGELFRTHFFLNAGNLCNLNYGEGPKAHIRKLAECIRWSYGAGIVLRLGNIARLELNYCVPMGVQTGDRICDGVQFGAGIRFL
Protein: AT3g54190/F24B22_150 (Transducin/WD40 repeat-like superfamily protein) (Q9C5G8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- F-box protein At4g35930
- At4g17760
- F-box protein SKIP27
- F-box protein At1g61340
- F-box protein At4g05010
- Calcium-dependent lipid-binding family protein
- Putative disease resistance protein At4g10780
- Heat shock 70 kDa protein 17
- Fumarate hydratase 2
Sequence:
MEGRRITASPRPCSGRRIVAKKRSRPDGFVNSVKKLQRREISSRKDRAFSISTAQERFRNMRLVEQYDTHDPKGHCLVALPFLMKRTKVIEIVAARDIVFALAHSGVCAAFSRESNKRICFLNVSPDEVIRSLFYNKNNDSLITVSVYASDNFSSLKCRSTRIEYILRGQPDAGFALFESESLKWPGFVEFDDVNGKVLTYSAQDSVYKVFDLKNYTMLYSISDKNVQEIKISPGIMLLIFKRAASHVPLKILSIEDGTVLKSFNHLLHRNKKVDFIEQFNEKLLVKQENENLQILDVRNAELMEVSRAEFMTPSAFIFLYENQLFLTFRNRNVSVWNFRGELVTSFEDHLLWHPDCNTNNIYITSDQDLIISYCKADTEDQWIEGNAGSINISNILTGKCLAKITPSSGPPKDDESSSSNCMGKNSKQRRNAVAEALEDITALFYDEERNEIYTGNRHGLVHVWSN
Protein: DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (C53) (DNA-directed RNA polymerase III 47 kDa polypeptide) (P25441)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC9
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase III subunit RPC1
- DNA-directed RNA polymerase III subunit RPC10
- DNA-directed RNA polymerase III subunit RPC5
- DNA-directed RNA polymerase III subunit RPC3
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
Sequence:
MSSNKGNGRLPSLKDSSSNGGGSAKPSLKFKPKAVARKSKEEREAAASKVKLEEESKRGNDKKHFNNKNKRVTGAGGQQRRMAKYLNNTHVISSGPLAAGNFVSEKGDLRRGFIKSEGSGSSLVQKGLETIDNGAESSENEAEDDDNEGVASKSKKKFNMGKEFEARNLIEDEDDGESEKSSDVDMDDEEWRSKRIEQLFPVRPVRVRHEDVETVKREIQEALSEKPTREPTPSVKTEPVGTGLQSYLEERERQVNEKLADLGLEKEFQSVDGKEAAAELELLNADHQHILRKLKKMNNKPERFMVFQLPTRLPAFERPAVKEEKEDMETQASDPSKKKKNIKKKDTKDALSTRELAGKVGSIRVHKSGKLSVKIGNVVMDIGKGAETTFLQDVIALSIADDASSAELLGRVDGKIVVTPQI
Protein: Insulin growth factor-like family member (Q6B9Z0)
Organism: Mus musculus (Mouse)
Function: Probable ligand of the IGFLR1 cell membrane receptor.
Subcellular location: Secreted {ECO:0000269|PubMed:21454693}.
Interaction partners:
- IGF-like family receptor 1
Sequence:
MKIRNACAVLIEVLLFILEGVTGARKISTFSGPGSWPCNPKCDGRTYNPSEECCVHDTILPFKRINLCGPSCTYRPCFELCCPESYSPKKKFIVKLKVHGERSHCSSSPISRNCKSNKIFHGEDIEDNQLSLRKKSGDQP
Protein: G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) (Q9NQ84)
Organism: Homo sapiens (Human)
Function: This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.
Interaction partners:
- Metabotropic glutamate receptor 2
Sequence:
MAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAVAGAGIVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTEWLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCGRYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVLFYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQKGQSMFVENKAFSMDEPVAAKRPVSPYSGYNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAEDMYSAQSHQAATPPKDGKNSQVFRNPYVWD
Protein: WNK lysine deficient protein kinase 2 (H0Y7J9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEARA
Protein: Glutaryl-CoA dehydrogenase, mitochondrial (EC 1.3.8.6) (D3ZT90)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
- Peroxisomal bifunctional enzyme
- Enoyl-CoA hydratase, mitochondrial
- Trifunctional enzyme subunit alpha, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- 2-oxoadipate dehydrogenase complex component E1
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 1
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Sequence:
MVPAMLTGYMSLRGVSAWLLSRKLGLRFSRVPRTWSSAAAHTEKTQIRSVKSSRPVFDWKDPLVLEEQLTADEKLIRDTFRNYCQERLMSRILLANRNEVFHRDIVYEMGELGVLGPTIKGYGCAGVSSVAYGLLTRELERVDSGYRSMMSVQSSLVMHPIYTYGSEEQRQKYLPRLAKGELLGCFGLTEPNHGSDPGSMETRARHNPSNKSYTLSGTKTWITNSPVADLFVVWARCEDNCIRGFLLEKGMRGLSAPRIEGKFSLRASATGMIIMDSVEVPEENVLPNVSSLAGPFGCLNTARYGITWGVLGAAEFCLHTARQYALDRIQFGVPLARNQLVQKKLADMLTEITLGLHACLQLGRLKDQDKATPEMVSLLKRNNCGKALDIARQARDILGGNGISDEYHVIRHAMNLEAVHMTSML
Protein: Zgc:103778 (Q5PR25)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MIGIAAASFFSNICQFGGCGLHFESLAELIVHIEDNHIDTDPRVLEKQELQQPTYVALSYINRFMTDAARREHESLKKKVQPKLSLSLMGSLSRSSVATPPRHNSGNLTPPVTPPITPVL