wanglab/gogpt-training-data huggingface dataset:
Protein: Pre-RNA processing 21 (Yeast PRP (Splicing factor) related) (G5ECL3)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Matrin-type domain-containing protein
- Splicing factor 3A subunit 2
- Splicing factor 3B subunit 1 domain-containing protein
- Splicing factor 3B subunit 4
- Probable U2 small nuclear ribonucleoprotein A'
- PSP proline-rich domain-containing protein
- RNA helicase
- Splicing factor 3B subunit 3
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Cell division cycle 5-like protein
Sequence:
MTAVVSNREEDSMNNEPSLSGRAIIGLIYPPPDIRTIVDKTARFAAKNGVDFENKIREKEAKNPKFNFLSITDPYHAYYKKMVYDFSEGRVEAPKVPQAVKEHVKKAEFVPSAPPPAYEFSADPSTINAYDLDLIRLVALFVARNGRQFLTQLMTREARNYQFDFLKPAHCNFTYFTKLVDQYQKVLVPSTNVVAQLQDDATNKKRLIEDINYRVSWEKHQKGLKDREEAEAEKERQAYASIDWHDFVVVQTVDFQPGDTSQLPPLCTPKDVGARILLEARNEMQKAAAEMQEMDMEESDSDDEDAVQAPEAPAFTAPLPPTKQKDVIVRDYDPKRNVTQKPKAVENWIISPLTGERIPSDKLAEHVRYNTVDSQYKEDRDRHIGERSTEEPVLALGADISRNLGNFAERRTDIFGVGGEQTMIGKKLGEEDNSQQGQNKLIWDGTEETRDMITRAVQNKVTLDQQINEIHRQHGFVADPSKEKIGAQQVPRHQSTQGNVTITQGITNIPGQMPSGWPPVPPMGMPGMPNQALPPIRQMDFGGGPPAKRPRTEDDLIPEADWLKKVNGAISLNVHLPQAPEHGMDGSIVQFTIQVTAPMSELKQQIQDRYGMPVGKQKLMSDGLFVKDNMSSAFYNLADRTAIYLQVKERGGKKK
Protein: Molybdate transporter 2 (Sulfate transporter like protein 5.1) (Q0WP36)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Molybdate transporter required for vacuolar molybdate export during senescence.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:21815974}; Multi-pass membrane protein {ECO:0000269|PubMed:21815974}.
Interaction partners:
- Molybdopterin synthase catalytic subunit
- GTP 3',8-cyclase, mitochondrial
- Cyclic pyranopterin monophosphate synthase, mitochondrial
- Molybdopterin synthase sulfur carrier subunit
- Molybdopterin biosynthesis protein CNX1
- Adenylyltransferase and sulfurtransferase MOCS3
- Protein RETICULATA-RELATED 4
Sequence:
METTTTPLLPGDRSRCGWLRRRLRLKNPLSSELSGAVGDLGTFIPIVLTLTLVSNLDLSTTLIFTGFYNIATGLLFDIPMPVQPMKSIAAVAVSESPHLTPSQIAAAGASTAATLLLLGATGAMSFLYNIIPLPVVRGVQLSQGLQFAFTAIKYVRFNYDTATLKPSSSPRIWLGLDGLILALAALLFIILSTGSGNDREAEDGDLAETSSNESQSRRRRLRLLSSIPSALIVFALGLVLCFIRDPSIFKDLKFGPSKFHILRISWDDWKIGFLRAAIPQIPLSVLNSVIAVCKLSNDLFDKELSATTVSISVGVMNLIGCWFGAMPVCHGAGGLAGQYRFGARSGLSVIFLGIGKLIVGLVFGNSFVRILSQFPIGILGVLLLFAGIELAMASKDMNSKEDSFIMLVCAAVSMTGSSAALGFGCGVVLYLLLKLRTLDCSSVTLFSRSSDESQVDSEAAPRDV
Protein: Methylsterol monooxygenase 2-1 (EC 1.14.18.11) (EC 1.14.18.9) (Sterol 4-alpha-methyl-oxidase 2) (AtSMO2) (Sterol 4-alpha-methyl-oxidase 2-1) (Q9ZW22)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Non-heme iron oxygenase involved in sterols biosynthesis by catalyzing the removal of the second methyl group at the C-4 position. 24-ethylidenelophenol and 24-ethyllophenol are the preferred substrates. Together with SMO2-2, required during embryogenesis, probably by maintaining sterols and auxin homeostasis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27006488}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ergosterol biosynthetic protein 28
- 24-methylenesterol C-methyltransferase 2
- Delta
- Probable 3-beta-hydroxysteroid-Delta
- Sterol 14-demethylase
- At2g33630/F4P9.40
- 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 3
- 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2
- 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1
- 24-methylenesterol C-methyltransferase 3
Sequence:
MDSLVESGWKYLVTHFSDFQLACIGSFILHESVFFLSGLPYIFLERTGFLSNYKIQTKSNTPEAQGKCIARLLLYHCCVNLPLMMASYPVFRFMGMESSFPLPSWKVVSAQILFYFIIEDFVFYWGHRILHTKWLYKNVHSVHHEYATPFGLTSEYAHPAEILFLGFATIVGPALTGPHLITLWLWMMLRVIETVEAHCGYHFPWSPSNFLPLYGGSLILMWESFAYSADFHDYHHRLLYTKSGNYSSTFVYMDWIFGTDKGYRKLKALKET
Protein: t-SNARE affecting a late Golgi compartment protein 1 (Syntaxin TLG1) (Q03322)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: SNARE protein (of Qc type) involved in membrane fusion probably in retrograde traffic of cytosolic double-membrane vesicles derived from both, early and possibly late endosomes/PVC (prevacuolar compartment) back to the trans-Golgi network (TGN or late Golgi). It has been reported to function both as a (target membrane) t-SNARE and as a (vesicle) v-SNARE. Upon vesicle tethering to the target membrane, which requires additional proteins, a SNARE-pin is formed. This is a very stable 4 parallel alpha-helical coil bundle consisting of 4 SNARE domains (usually one of each type: Qa, Qb, Qc, and R), of which at least one is anchored in the opposite membrane. The formation of the SNARE-pin is believed to bring the two membranes in close proximity and to provide the energy to drive membrane fusion. Through its interaction with the VFT (or GARP) complex, it may also contribute to vesicle recognition specificity and tethering. Regulation of SNARE-pin formation also seems to depend on the phosphorylation state of the protein, phosphorylation by TPK1 causing inhibition and dephosphorylation by SIT4 activation.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Probably shuttling between TGN and early/late endosome.
Interaction partners:
- t-SNARE VTI1
- t-SNARE affecting a late Golgi compartment protein 2
- Vacuolar v-SNARE NYV1
- Synaptobrevin homolog 2
- Synaptobrevin homolog YKT6
- Integral membrane protein SED5
- Protein transport protein SEC22
- Synaptobrevin homolog 1
- Vacuolar protein sorting-associated protein 45
- Vacuolar protein sorting-associated protein 51
Sequence:
MNNSEDPFQQVVKDTKEQLNRINNYITRHNTAGDDDQEEEIQDILKDVEETIVDLDRSIIVMKRDENEDVSGREAQVKNIKQQLDALKLRFDRRIQESTQTTIPLEETVENSTLNTSMAENNDGGMSNPFQEQMLREQDVHLDGIHKTMQNLHIQAQTMGDELENQGQLLDNMDEGMDGVVNKLARGRRQLEWVYEKNKEKYDDCCIGLLIVVLIVLLVLAFIA
Protein: Ubiquitin C-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (AtUBP13) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) (Q84WU2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Positive regulator of root meristem development that, together with UBP12, prevents the ubiquitination and turnover of RGFR1 induced by the RGF1 hormone peptide, thus influencing PLT1 and PLT2 expression.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 14
- Ubiquitin-ribosomal protein eL40y fusion protein
- GMP synthase
- Ubiquitin-ribosomal protein eL40z fusion protein
- E3 ubiquitin-protein ligase UPL3
- E3 ubiquitin-protein ligase UPL4
- Ubiquitin-ribosomal protein eS31y fusion protein
- Ubiquitin-ribosomal protein eS31z fusion protein
- Ubiquitin-ribosomal protein eS31x fusion protein
- Ubiquitin carboxyl-terminal hydrolase 24
Sequence:
MTMMTPPPLDQQEDEEMLVPNPDLVEGPQPMEVAQTDPAATAVENPPPEDPPSLKFTWTIPMFTRLNTRKHYSDVFVVGGYKWRILIFPKGNNVDHLSMYLDVADAANLPYGWSRYSQFSLAVVNQVNNRYSIRKETQHQFNARESDWGFTSFMPLSELYEPTRGYLVNDTVLIEAEVAVRKVLDYWSYDSKKETGFVGLKNQGATCYMNSLLQTLYHIPYFRKAVYHMPTTENDAPTASIPLALQSLFYKLQYNDTSVATKELTKSFGWDTYDSFMQHDVQELNRVLCEKLEDKMKGTVVEGTIQKLFEGHHMNYIECINVDYKSTRKESFYDLQLDVKGCKDVYASFDKYVEVERLEGDNKYHAEGHDLQDAKKGVLFIDFPPVLQLQLKRFEYDFMRDTMVKINDRYEFPLQLDLDREDGRYLSPDADKSVRNLYTLHSVLVHSGGVHGGHYYAFIRPTLSDQWYKFDDERVTKEDVKRALEEQYGGEEELPQNNPGFNNPPFKFTKYSNAYMLVYIRESDKDKIICNVDEKDIAEHLRVRLKKEQEEKEDKRKYKAQAHLFTTIKVARDDDITEQIGKNIYFDLVDHEKVRSFRIQKQTPFQQFKEEVAKEFGVPVQLQRFWIWAKRQNHTYRPNRPLSPNEELQTVGQIREASNKANNAELKLFLEIERGPDDLPIPPPEKTSEDILLFFKLYDPENAVLRYVGRLMVKSSSKPMDIVGQLNKMAGFAPDEEIELFEEIKFEPCVMCEQIDKKTSFRLCQIEDGDIICYQKPLSIEESEFRYPDVPSFLEYVQNRELVRFRTLEKPKEDEFTMELSKLHTYDDVVERVAEKLGLDDPSKLRLTSHNCYSQQPKPQPIKYRGVDHLSDMLVHYNQTSDILYYEVLDIPLPELQGLKTLKVAFHSATKDEVIIHNIRLPKQSTVGDVINELKTKVELSHQDAELRLLEVFFHKIYKIFPSTERIENINDQYWTLRAEEIPEEEKNIGPNDRLIHVYHFTKEAGQNQQVQNFGEPFFLVIHEGETLEEIKTRIQKKLHVPDEDFAKWKFASFSMGRPDYLLDTDVVYNRFQRRDVYGAWEQYLGLEHIDNAPKRAYAANQNRHAYEKPVKIYN
Protein: BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Ubiquitin interaction motif-containing protein 1) (Q5U5Q9)
Organism: Mus musculus (Mouse)
Function: Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96RL1}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250|UniProtKB:Q96RL1}.
Interaction partners:
- BRISC and BRCA1-A complex member 2
- BRCA1-A complex subunit Abraxas 1
- Breast cancer type 1 susceptibility protein homolog
- BRISC and BRCA1-A complex member 1
- Lys-63-specific deubiquitinase BRCC36
- BRCA1-associated RING domain protein 1
- Mediator of DNA damage checkpoint protein 1
- TP53-binding protein 1
- E3 ubiquitin-protein ligase RNF8
- E3 ubiquitin-protein ligase RNF168
Sequence:
MPRRKKKIKEASESQNLEKKDLETSSCVSIKKKRRLEDLLIVISDSDGEETKEENGLQKTKTKQSNRSKCLAKRKVAHMSEEEQFALALKMSEQEAREVNNQEEKEEELLRKAIAESLNSCWSSAASATRSRPLAAELSSHSHQENTKDSGTTEGVWQLVPPSLCKGSHVSQGNEAEQRKEPWDHNENTEEEPVSGSSGSWDQSSQPVFENENVKCFDRCTGHLAEHTQCGKPQESTGSGYAFSKAVQGRGDTSRQCLPIPADTKGLQDTGGTVHYYWGIPFCPAGVDPNQYTNVILCQLEVYQKSLKMAQRQLVKKRGFGEPVLPRPPFLIQNECGQEDQTSDKNEGISEDMGDEAKEERQESRASVWHSETKDFQKSPIKSLKQKLLLEEEPTTSRGQSSQGLFVEETSEEGLKSSEGDNSVPTTQSIAALTSKRSLVLMPESSAEEITVCPETQLSFLEPLDLNREDSPDSRELPIEVRMAVGDKQVANREDCMKENPPPAVSSSTRVSCPLCNQDFPPTKIEQHAMYCNGLMEQETVLTRRRREAKNKSDGRTAAQPALDANRKEKCYLCKSLVPLGEYQCHVEACLQLAKVDREDGIEGTRRPRVCAPVEGKQQQRLKKSKDKGHSQGRLLSLLEQSEHRTTGVEKKPKYSEVRTFRMPSPEVEEASCSREMQSTLSQLNLNESPIKSFVPVSEATNCLVDFKEQFAFRSRTKSGRGRRRKS
Protein: Growth hormone (H6ULW9)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MAPGSWFSPLLIAVVTLGLPQEAAATFPAMPLSNLFANAVLRAQHLHLLAAETYKEFERTYIPEDQWYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMEVVRFSLVFIQSWLTPVQYLSKVFTNKLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRNEDALLKNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI
Protein: SET domain-containing protein (Q38BE1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Histone H2A
- Histone H3, putative
- Histone H3 variant
- Histone H4
- Histone H4
- Histone H2B
- Histone H2B
- Histone H2B
- Histone H2B
- Trypanothione synthetase, putative
Sequence:
MQTEALQHRMSKADLVAVFCDKGCETAMTAQLIPLARFPFKLFPVCNGPSMYRAVREIYASRNLYRCALNLCTGTAEDEELASPQVLSSLFEHFDILYGGCRYATLRQPLDVLFMMAFYAGLPLPRSTVVKADTQTDYLELRLPVKLRNANPLQSRFETVVEKKSALLRMVRQGIQSHGKLIAWEVSPVKDMGLEVLVWGAGSFAVATEPPRQQDDAFIKKWKPSIEKWAAAFSKDVLNRSGFARLRFNSSTTSEKLVLEDIDVGCSLLGLCTQLSIVASQEGLLDECVRECERAPLAPVAEVCFGGENKGYYLRASRDVPKGGLVFEDEERSFSIVTRPFVEKTWDEEKKKLFREYAWPIDADGHVYVTWDSDPNCWRPINHSCEPNCIFDENHSLNVIAARDIAKGDELTMDYCTFCDNTMKPFSCFCGSAYCREIIVPNEESLRAYGTHAWHRKVPAPHLNDL
Protein: Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II) (Q710C1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Interaction partners:
Sequence:
MGRKRNNFYMRSLFLLALGIFGLLQYNNFNYLDSRDNVLGDAVTNDSDDAILAMVPATLHKYLTPHSRNHSASGAGVLNGAALLLNASSPGAATASTISFDVYHPPNITEIKRQIVRYNDMQMVLNEDVFGPLQNDSVIIVVQVHTRITYLRHLIVSLAQARDISKVLLVFSHDYYDDDINDLVQQIDFCKVMQIFYPYSIQTHPNEYPGVDPNDCPRNIKKEQALITNCNNAMYPDLYGHYREAKFTQTKHHWIWKANRVFNELEVTRYHTGLVLFLEEDHYVAEDFLYLLAMMQQRTKDLCPQCNVLSLGTYLKTFNYYTYHSKVEVMPWVSSKHNMGFAFNRTTWSNIRKCARHFCTYDDYNWDWSLQHVSQQCLRRKLHAMIVKGPRVFHIGECGVHHKNKNCESNQVISKVQHVLRIARNSHQLFPRSLTLTVPSLMKKSKLRKGNGGWGDMRDHELCLNMTLATR
Protein: Cryptic loci regulator 2 (O13881)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for deacetylation in the mating-type region and the centromere. Acts upstream of the histone deacetylases to promote transcriptional silencing. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).
Subcellular location: Nucleus {ECO:0000269|PubMed:17289569}. Chromosome, centromere {ECO:0000269|PubMed:17289569}. Chromosome, telomere {ECO:0000269|PubMed:17289569}. Note=Associates with major heterochromatin, centromeres, sub-telomeres, rDNA and the mat locus.
Interaction partners:
- Chromatin remodeling factor mit1
- Cryptic loci regulator protein 1
- Histone deacetylase clr3
- Chromo domain-containing protein 2
- Coiled-coil quantitatively-enriched protein 1
- Histone-lysine N-methyltransferase, H3 lysine-9 specific
- Chromatin-associated protein swi6
- Silenced mating-type M-specific polypeptide Mi
- Chromatin modification-related protein rik1
Sequence:
MPAITCVWSDGRSDTWPNVNGHSRTRSVPSLKPLPHQDSKNLLYRQICGRLLAQHVFGGAGSTQPILNQLCKRLSTGNPNNTNASTVVTAPEKNVVSARHVRPNPKSSKDTLEKQPKYSSQIYLTDSFENYYLASLPTNYQLYQRDSNRENGNGKREFWLYGHPSGRPFRSVNDFLHHLYWLISDLTRNESTCCCVLCSGNMTRVRKNLQKENERMFHECKDDTYTWPSSYRLGEVVWIDINNELIPAIIVARNLINYESNQMDAVKLISDTFVEPYQYHCKQLGNSRYYFDMAAADIEPWSRHPLDLQKQEHLVAHSICQTWNLFGIFQPLEGIDMEEPKFHDENYSIPLTVLPTFGGESNSLDDHFYGIFRGAEKLWINDLCVISTSSLPSVLQKTSFMYISDIYVNEDDIVCFQGSLWTQIDKNALDYNDSADNIDEHKDDLKELPRRLQMVSKLSNTYFRCLHDKSVEYVCPFADVLGRWYEPWFVKGDLNYTSEVKERTSSRLSAVGSENWVDDDFYEYLLSEIDMVSAVVM
Protein: Small ribosomal subunit protein uS2m (28S ribosomal protein S2, mitochondrial) (MRP-S2) (S2mt) (Q924T2)
Organism: Mus musculus (Mouse)
Function: Required for mitoribosome formation and stability, and mitochondrial translation.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9Y399}.
Interaction partners:
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS10m
Sequence:
MAPAPAVLTRLLCAGVRRWPGFLQKAIPGPAEQNGRKVTGAPVPAVSEPQDGDDFQSRILDTPLQHSDFFNVKELFSVKSLFEARVHLGHKAGCRHRFMEPYIFGNRLGQDIIDLDQTALNLQLALNFTAHVAYRKGIILFVSRNRQFSHLIETTAQACGEYAHTRYFKGGLLTNAQLLFGPSVRLPDLIIFLHTLNNVFEPHVAVRDAAKMNIPTVGIVDTNCNPCLITYPIPGNDDSPQAIQLFCKLFRTTINRAKEKRRQMEALHRLQSPKGSEGSGTSPVPDKSHSP
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q2THW6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004653}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004225}.
Interaction partners:
- P-type phospholipid transporter
- Large ribosomal subunit protein mL40
- Transport and golgi organization 2 homolog
- Catechol O-methyltransferase
- Proline dehydrogenase
Sequence:
MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAIPVYNGILFLFVLANFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHMVGVVAFGLLYVLNHSEGLGAAHTTITMAVMCVAGLFFIPVIGLTGFHVVLVTRGRTTNEQVTGKFRGGVNPFTRGCYGNVEHVLCSPLAPRYVVEAPRMPLSVSLKPPFLRPELLERAVPLKVKLSDNGLKAGRSKSKGSLDQLDEKPLDLGPPLPPKMEAGTFGRDLKTPRPGSAESALSVQRTSPPTPAMYKFRPAFSTAPKTPFCGPSEQVPGPDSLTLADDSTHSLDFVSEPSLDLPDHGPGGLHPTYPPSPPLSATDAFSGALRSLSLKAASRRGGDHMTLQPLRSEGGPPTPHRGLFAPHALPNRNGSLSYDSLLNPGSPSGHACPTHPSVGMAGYHSPYLHPGPSDPPRPPPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQTDSLFGDSGVYDTPSSYSLQQASVLTEGPRGSVLRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSMSRAPRTSSSSLQADQANNNAPGPRPGSGSHRSPARQGLPSPPGTPRSPSYSGSKAVAFIHTDLPDRQPSLAMQRDHPQLKTPPSKLNGQSPGMARLGPAASPMGPNASPARHTLVKKVSGVGGTTYEISV
Protein: DASH complex subunit spc34 (Outer kinetochore protein spc34) (O14285)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore.
Subcellular location: Nucleus {ECO:0000269|PubMed:16079914}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16079914}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16079914}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:20624975}. Note=Associates with the mitotic spindle and the kinetochore. Kinetochore association occurs only during mitosis (PubMed:16079914). In the cytoskeleton, localizes to cortical microtubules (Probable). {ECO:0000269|PubMed:16079914, ECO:0000305|PubMed:20624975}.
Interaction partners:
- DASH complex subunit duo1
- DASH complex subunit ask1
- DASH complex subunit dad2
- DASH complex subunit dad1
- DASH complex subunit dad4
- DASH complex subunit spc19
- DASH complex subunit dad3
- DASH complex subunit dam1
- Kinetochore protein ndc80
- DASH complex subunit DAD5
Sequence:
MSDLLNYLQSIAATSEKLLEPENPNAARFTDAVLHTHAITDLIRDTQKEELIAAEFKSLPKDWSERLASENPADYVACIEELLDIYPMQGGREYLETLVEKYNLHMSGIENLENVLLEQKEQLQQLEKRQTDQVSARENILQRETSEIQRLEREIEKVKQLIQS
Protein: NAD-capped RNA hydrolase NudC (DeNADding enzyme NudC) (EC 3.6.1.-) (NADH pyrophosphatase) (EC 3.6.1.22) (P32664)
Organism: Escherichia coli (strain K12)
Function: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates, but uniquely prefers the reduced form of NADH.
Interaction partners:
- Nucleoside triphosphate pyrophosphohydrolase
- Nicotinate phosphoribosyltransferase
- Trifunctional NAD biosynthesis/regulator protein NadR
- Nicotinate-nucleotide adenylyltransferase
- 5'/3'-nucleotidase SurE
- NAD-dependent protein deacylase
- Protein UshA
- NH
- Soluble pyridine nucleotide transhydrogenase
- NAD kinase
Sequence:
MDRIIEKLDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLVQQQRRHDMGSVRQVIDLDVGLFQLAGRGVQLAEFYRSHKYCGYCGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGDIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCRAEYE
Protein: SCD domain-containing protein (Q38B04)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
- Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein
- Sister chromatid cohesion protein
- Double-strand-break repair protein rad21 homolog, putative
- EF-hand domain-containing protein
- Structural maintenance of chromosomes protein
- Sister chromatid cohesion protein
- Uncharacterized protein
- Structural maintenance of chromosomes protein
- DNA polymerase eta
Sequence:
MPRKVKTKVSQKPKAAKVSPTPKNERERPKNVDASGKAAKLCTEEPTAPVIVPEEGTSLMESLFTALAGGVSPSRVASDVLRLYCEGNRQELCAAILNLVGKVSGVVDGELGAAAVEGNTDMNTLLDEMFAHVPENAPAYLFSQRDPKSQKLRIAYGQFFMRLVELSYSENLMFDQFLLPTVVAWLVAMSESKARCFRHTSTATLLYVVDALSCVIQTLNGQVCADKRNKKHADAKQRVIQAVVEQRNQILTQTVHQRARDVAPEIRLLVFESLKGWILKFDEEFAENKYFRYFGMALYDKRPEIRAEALAMIQETLDSIPDSGSRMFLFLQYFSKRLVEMCNDVNLHCSQLAIGVIRRILRIFSAEAEDKQLLNNEMIDSVLLNIFSECPTIRREAGALLHDFIETRLPTDERDESAGLQAMTELLCTFAAMLRSQHGEMMPERYIVDSLYTPPQDIPPLLREYGPILKLAQSDAATDVVVALGFLSALLEKLRGRTDLGPIPKDDRKGAQEKKISADKQEAITAVIGSMSRDVGVVLTGVLERHRSDVAVVGAVAAVISAMDMEAFISLQDVSQIKSLLVLMRKVTAALPHSDQLSLVPITGAWHALVSEEHPLVVEAKGQLQELRRQVVKQLTANGSTPSRASGEAWEREQLHLWTRVSIVSSLVPMGDLLTLFKSSFLHHVEARASPELIQLVLTSLVRCVLWQLREAQEQTHEHREPTTPGGADDSGVTSDVRDVISQLIGELFRCVSLMWTAYAEHVGADATGLLVDGMLILCDLCVLPHYILSEAERNEVLDRFAQLSQLLGSKVTSAREELKKAEAGALEGDQPIPLAPLRRKVSYLESSQMRVSMGVARLMMLKRLPESAGPRVLAQWGHAPTKAVSDIFRCLFRKLRDHSGDSLSLEWSVLLAAREQSADSLSAVGVKLSSMHWPLPDKYYSACVGIVRCGIEFAATVDPTVLLALVPYCSRLLRNDAVALVSILSQREKLASSTDHTVMAFVSSLRRAAKLDGTPNILPASVTKRPRDVSPSLDLCGNSLPEHMPAPRFAGKGGVSPQTGDQRSSLGTHWVGNRMLSADGWRIPHKEVGTNLSCAGKVGMEGSNLTASSVEGEFIGSSQETHSVMGSLPTVDTPTLTLTQRTNTSCLDGFDNSEVFIATMEYE
Protein: Probable inactive purple acid phosphatase 14 (Q84LR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Probable inactive purple acid phosphatase 24
- At3g12470
- Uncharacterized protein
- CASP-like protein
- Gb|AAD55616.1
- Putative F-box/LRR-repeat protein At3g59230
- B3 domain-containing protein At5g60130
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Leucine-rich repeat
- Choline transporter-like protein
Sequence:
MEETRRRFVISSVLSVSLIYLCLSTCHVSAFDFGRRQLRFNTDGRFKILQVSDMHYGFGKETQCSDVSPAEFPYCSDLNTTSFLQRTIASEKPDLIVFSGDNVYGLCETSDVAKSMDMAFAPAIESGIPWVAILGNHDQESDMTRETMMKYIMKLPNSLSQVNPPDAWLYQIDGFGNYNLQIEGPFGSPLFFKSILNLYLLDGGSYTKLDGFGYKYDWVKTSQQNWYEHTSKWLEMEHKRWPFPQNSTAPGLVYLHIPMPEFALFNKSTEMTGVRQESTCSPPINSGFFTKLVERGEVKGVFSGHDHVNDFCAELHGINLCYAGGAGYHGYGQVGWARRVRVVEAQLEKTMYGRWGAVDTIKTWKRLDDKNHSLIDTQLLWTKNTTLEPNFGFSCSTIPQH
Protein: Large ribosomal subunit protein uL1 (50S ribosomal protein L1) (P0A7L0)
Organism: Escherichia coli (strain K12)
Function: One of the primary rRNA binding proteins, it binds very close to the 3'-end of the 23S rRNA. Forms part of the L1 stalk. It is often not seen in high-resolution crystal structures, but can be seen in cryo_EM and 3D reconstruction models. These indicate that the distal end of the stalk moves by approximately 20 angstroms. This stalk movement is thought to be coupled to movement of deacylated tRNA into and out of the E site, and thus to participate in tRNA translocation. Contacts the P and E site tRNAs.
Interaction partners:
- Elongation factor G
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein bL20
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein bS18
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL18
Sequence:
MAKLTKRMRVIREKVDATKQYDINEAIALLKELATAKFVESVDVAVNLGIDARKSDQNVRGATVLPHGTGRSVRVAVFTQGANAEAAKAAGAELVGMEDLADQIKKGEMNFDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFDADKLKENLEALLVALKKAKPTQAKGVYIKKVSISTTMGAGVAVDQAGLSASVN