wanglab/gogpt-training-data huggingface dataset:
Protein: Attacin-D (Q9VEH5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Diptericin B
- Cecropin-B
- Metchnikowin
- Defensin
- Cecropin-C
- Elevated during infection
- Diptericin A
- Cecropin-A1
- Drosocin antimicrobial peptides
- Peptidoglycan-recognition protein SD
Sequence:
MECQASGNPKSGAATAQCGVRVGDDLANARAGVFASTPGAGGPVTKGVYGAVNANGHALSLQHGHIEGVGSTTTAAAQANLFQSNNAALNATAFHSHSRSHDQFGGGLNLQTGTGHQAAVGVTRVPQFGMTAVQASGTANLYTSPSGNLNLNATGSANHHLRGPMRGKSDFGTGVNLRYNF
Protein: Photosystem I P700 chlorophyll a apoprotein A2 (EC 1.97.1.12) (PSI-B) (PsaB) (Q6ENH5)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
Subcellular location: Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Interaction partners:
- Photosystem I reaction center subunit III
- Photosystem I iron-sulfur center
- Photosystem I reaction center subunit II
- Photosystem I P700 chlorophyll a apoprotein A1
- Uncharacterized protein
- NAD
- Photosystem I reaction center subunit IX
- Photosystem I reaction center subunit VIII
- Chlorophyll a-b binding protein
- Photosystem I reaction center subunit psaK, chloroplastic
Sequence:
MELRFPRFSQGLAQDPTTRRIWFGIATAHDFESHDDITEERLYQNIFASHFGQLAIIFLWTSGNLFHVAWQGNFESWIQDPLHVRPIAHAIWDPHFGQPAVEAFTRGGAAGPVNIAYSGVYQWWYTIGLRTNEDLYTGALFLLFLSTLSLIGGWLHLQPKWKPSLSWFKNAESRLNHHLSGLFGVSSLAWTGHLVHVAIPASRGEYVRWNNFLDVLPYPQGLGPLLTGQWNLYAQNPDSSNHLFGTTQGAGTAILTLLGGFHPQTQSLWLTDIAHHHLAIAFIFLIAGHMYRTNFGIGHSIKDLLEAHTPPGGRLGRGHKGLYNTINNSIHFQLGLALASLGVITSLVAQHMYSLPSYAFIAQDFTTQAALYTHHQYIAGFIMTGAFAHGAIFFIRDYNPEQNEDNVLARMLDHKEAIISHLSWASLFLGFHTLGLYVHNDVMLAFGTPEKQILIEPIFAQWIQSAHGKTTYGFDILLSSTSGPAFNAGRTLWLPGWLNAVNENSNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWVTFYWHWKHITLWQGNVSQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLSVWAWMFLFGHLVWATGFMFLISWRGYWQELIETLAWAHERTPLANLIRWRDKPVALSIVQARLVGLAHFSVGYIFTYAAFLIASTSGKFG
Protein: Protein-tyrosine phosphatase 2 (AFU_orthologue AFUA_3G10970) (C8V9H4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MAHPTIKIDTSVQANKRSHPDNEDGVGVVDGSDDDNPEMELGDNEHVPPFLRQSVLDIRHKFEELEYMQGTRILEGSRANDPSHRWALDADPEVRARNRYANVQAWANSRIHLRVPEGECDFINASPIVLRDSVSQEERKYIATQGPRLDDLYHFWNMVFHETGEVAVVVMLTQTMEAGREKCSQYFPLEIENPMYLRQDNSNPHLESEQQELEGGDVLGHITLLESTWDLECRSEIRRLQLTLGSDSKTVWHFLFAGWADYSKPVGDDRDALLHLIKLSASKASSPQNPRIVHCSAGVGRTGTFIALDHLLQELESGQLLKVTDEDIDPVFETVNLMREQRMMMVYNEMQLIFIYEVLREQVDIILEKTYGISRQRSVARSAKIAKLSEEDYLPAPKPELEAAGDLSDTRAPEHSDTD
Protein: Secretory component protein shr3, putative (AFU_orthologue AFUA_4G09660) (C8VPQ8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MTLRYGSFATFLIVCPTSFFLGIIFSLFPYDYPILWSTSPTDSTAYDSLETHLRLLHASPPLIPRILHIVIFLGLAGLIMKLWKPSESNMLFDGASLVLYACGITVYVANIVKGLRLASGGVYGAELANAPDEVGQILGREDSLKVLSASNTILALVLVGVLVLQAGQWYAERKDAQEDESFAAVKGEGKGKGATKKKAN
Protein: Collectin-10 (Collectin liver protein 1) (CL-L1) (Collectin-34) (CL-34) (Q9Y6Z7)
Organism: Homo sapiens (Human)
Function: Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration.
Subcellular location: Secreted {ECO:0000269|PubMed:28301481}. Golgi apparatus {ECO:0000250|UniProtKB:Q8CF98}. Cytoplasm {ECO:0000269|PubMed:10224141}.
Interaction partners:
- Collectin-11
- Mannan-binding lectin serine protease 2
- Ficolin-2
- MBL associated serine protease 1
- Ficolin-3
- Mannose-binding protein C
- Ficolin-1
- Myeloid cell surface antigen CD33
- Collagen alpha-1
- Killer cell immunoglobulin-like receptor 3DL1
Sequence:
MNGFASLLRRNQFILLVLFLLQIQSLGLDIDSRPTAEVCATHTISPGPKGDDGEKGDPGEEGKHGKVGRMGPKGIKGELGDMGDQGNIGKTGPIGKKGDKGEKGLLGIPGEKGKAGTVCDCGRYRKFVGQLDISIARLKTSMKFVKNVIAGIRETEEKFYYIVQEEKNYRESLTHCRIRGGMLAMPKDEAANTLIADYVAKSGFFRVFIGVNDLEREGQYMFTDNTPLQNYSNWNEGEPSDPYGHEDCVEMLSSGRWNDTECHLTMYFVCEFIKKKK
Protein: Cd69 molecule (A0A0G2JYI2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MNSEECSITENSSSHLERGQRVGKYNCPGFYENLESFDHHAASCKNEWFSYNGKCYFFSTTTKTWALAQKSCSEDDATLAVIDSEKDMAFLKRYAGGLKHWIGLRNEASQTWKWANGKEFNSWFNVTGSKKCVSLNHTDVASVDCEANLHWICSKASL
Protein: DUF4139 domain-containing protein (Q584R7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nucleoside diphosphate kinase-like domain-containing protein
- Uncharacterized protein
- DNA
Sequence:
MSSVSSDHIELIPSLKGVTVFSDRAQLAFVASTALECGTHIIHLRPEGNWEDMITNTLLVKVQDGSNRHVAVHDVRLKHTDLTEEVREGVRVLKDSIDELQGKIDAVTDKKKVQSAVEAAVEKIEKKLMIMGERDCPSRAHKQLTDTTAITLFLSQPSSWMELICFISGRKRHVRECLLELKDEETKLQASLSKLQEELGEMQRGKRRQRRNTTVEVTLTVREQPTELKLNVSFVVTGASWKPLYDMRVSSSASTMDLTYYAQVQQRTPIDWNKVQLKVSTAAPHFGTQPPKLATWRISLKPPIANLKPRLLAMNLRGMPMPCAAKAVDTTDCNAAPREARVKQAIVSSSSPFSGAISSFHVLGLTTVRNNNRLVKVAIAKQTFPVELEYHAVPKSDKRVFRTAKAKNTSPYIFLPGKSHIFVDSTFMCGSRLDLVPAGADFSASLGADERVEVVRKEVKRTRSIVTRVVRSPLVRMDHVYEFSVKGTVQRETTLLVRDQCPLSPDDEVKVCVVEPSSKALKGRLTADGMKCAMDQMGMIEWKLKLSPGANNHVFRYAFQVEHPERLTVRGV
Protein: Uncharacterized lyase C29B12.13 (EC 4.-.-.-) (O14034)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MPEYEGNCLCKAIHLKAIIEEPKLSCCHCETCRIWCSSPFMAFSCTQKPSVSENENVGKYASSSFAERIFCKNCGTTLYFAYTNGKNPYFINAWLFKGIENITFDAQVCIDDKPDCYDFANKTSMFTVDEVMKSIVK
Protein: Negative elongation factor E (NELF-E) (RNA-binding protein RD) (P19426)
Organism: Mus musculus (Mouse)
Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:31399344}. Chromosome {ECO:0000269|PubMed:31399344}. Note=Localizes to chromatin (PubMed:31399344). Phosphorylation by the P-TEFb complex promotes its release from chromatin (PubMed:31399344). {ECO:0000269|PubMed:31399344}.
Interaction partners:
- Negative elongation factor B
- Negative elongation factor A
- Negative elongation factor D
- Transcription elongation factor SPT5
- Transcription elongation factor SPT4-A
- DNA-directed RNA polymerase II subunit RPB1
- Nuclear cap-binding protein subunit 1
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- Nuclear cap-binding protein subunit 2
Sequence:
MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSGPASQGGVKRSLSEQPVVDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSMSADEDLQEPSRRPQRKSLYESFVSSSDRLRELGQDGEEAEAPGAGDGPPRGFDWSYEEHGSARSSASPPRSRSRDRSHDRSRDRDRDKERDRDRDRDRDRDRDKDKDRDRDRDRDKERDRDRDRDRDRERDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDL
Protein: Protein RseC (P46187)
Organism: Escherichia coli (strain K12)
Function: May play a role in reduction of the SoxR iron-sulfur cluster. May work together with the RsxABCDGE complex.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sigma-E factor regulatory protein RseB
- Anti-sigma-E factor RseA
- ECF RNA polymerase sigma-E factor
- Ion-translocating oxidoreductase complex subunit C
- Intermembrane phospholipid transporter YhdP
- Ion-translocating oxidoreductase complex subunit G
Sequence:
MIKEWATVVSWQNGQALVSCDVKASCSSCASRAGCGSRVLNKLGPQTTHTIVVPCDEPLVPGQKVELGIAEGSLLSSALLVYMSPLVGLFLIASLFQLLFASDVAALCGAILGGIGGFLIARGYSRKFAARAEWQPIILSVALPPGLVRFETSSEDASQ
Protein: Transmembrane protein 150C (Tentonin 3) (B9EJG8)
Organism: Homo sapiens (Human)
Function: Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25608530}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000305|PubMed:25608530}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker (PubMed:25608530). {ECO:0000269|PubMed:25608530}.
Interaction partners:
Sequence:
MDGKKCSVWMFLPLVFTLFTSAGLWIVYFIAVEDDKILPLNSAERKPGVKHAPYISIAGDDPPASCVFSQVMNMAAFLALVVAVLRFIQLKPKVLNPWLNISGLVALCLASFGMTLLGNFQLTNDEEIHNVGTSLTFGFGTLTCWIQAALTLKVNIKNEGRRVGIPRVILSASITLCVVLYFILMAQSIHMYAARVQWGLVMCFLSYFGTFAVEFRHYRYEIVCSEYQENFLSFSESLSEASEYQTDQV
Protein: U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) (Q62376)
Organism: Mus musculus (Mouse)
Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:17656373}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17656373}. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000269|PubMed:17656373}.
Interaction partners:
- U1 small nuclear ribonucleoprotein A
- Small nuclear ribonucleoprotein Sm D2
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein F
- Serine/arginine-rich splicing factor 1
- Small nuclear ribonucleoprotein-associated protein B
Sequence:
MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKDERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGGGGGGSGGGGGGDMAEPSEAGDGAPDDGPPGELGPEGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDREHKRGERGSERGRDEARGGGGSGQDNGLEGLGSDGRDMYMEAEGGDGYMAPENGYLMEAAPE
Protein: RE39037p (Q8SYR8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLALLASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIFNIFGSNKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSSHSNGSADDHHDDGDDQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEITLYA
Protein: Receptor for retinol uptake stra6 (Stimulated by retinoic acid gene 6 protein homolog) (F1RAX4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Retinol transporter. Accepts retinol from the extracellular retinol-binding protein rbp4, mediates retinol transport across the cell membrane, and then transmits retinol to the cytoplasmic retinol-binding protein rbp1. Required for normal vitamin A homeostasis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27563101}; Multi-pass membrane protein {ECO:0000269|PubMed:27563101}.
Interaction partners:
- Plasma retinol-binding protein II
- Calmodulin
- Transthyretin
- Aldehyde dehydrogenase 1 family member A3
- Retinol dehydrogenase 10-B
- Cytochrome P450 26A1
- Short-chain dehydrogenase/reductase 3
- Cytochrome P450 26B1
- Spalt-like transcription factor 2.
- Beta-carotene oxygenase 1.
Sequence:
MSAETVNNYDYSDWYENAAPTKAPVEVIPPCDPTADEGLFHICIAAISLVVMLVLAILARRQKLSDNQRGLTGLLSPVNFLDHTQHKGLAVAVYGVLFCKLVGMVLSHHPLPFTKEVANKEFWMILALLYYPALYYPLLACGTLHNKVGYVLGSLLSWTHFGILVWQKVDCPKTPQIYKYYALFGSLPQIACLAFLSFQYPLLLFKGLQNTETANASEDLSSSYYRDYVKKILKKKKPTKISSSTSKPKLFDRLRDAVKSYIYTPEDVFRFPLKLAISVVVAFIALYQMALLLISGVLPTLHIVRRGVDENIAFLLAGFNIILSNDRQEVVRIVVYYLWCVEICYVSAVTLSCLVNLLMLMRSMVLHRSNLKGLYRGDSLNVFNCHRSIRPSRPALVCWMGFTSYQAAFLCLGMAIQTLVFFICILFAVFLIIIPILWGTNLMLFHIIGNLWPFWLTLVLAALIQHVASRFLFIRKDGGTRDLNNRGSLFLLSYILFLVNVMIGVVLGIWRVVITALFNIVHLGRLDISLLNRNVEAFDPGYRCYSHYLKIEVSQSHPVMKAFCGLLLQSSGQDGLSAQRIRDAEEGIQLVQQEKKQNKVSNAKRARAHWQLLYTLVNNPSLVGSRKHFQCQSSESFINGALSRTSKEGSKKDGSVNEPSKEAESAAASN
Protein: Ly6/PLAUR domain-containing protein 6 (D3ZTT2)
Organism: Rattus norvegicus (Rat)
Function: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs (By similarity). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (By similarity). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q86Y78}. Cytoplasm {ECO:0000250|UniProtKB:Q86Y78}. Cell membrane {ECO:0000269|PubMed:27344019}; Lipid-anchor, GPI-anchor {ECO:0000255}. Synapse, synaptosome {ECO:0000269|PubMed:27344019}. Membrane raft {ECO:0000250|UniProtKB:Q66IA6}. Cell projection, dendrite {ECO:0000269|PubMed:34631692}. Perikaryon {ECO:0000269|PubMed:34631692}. Note=Colocalizes with alpha-3:beta-4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus. {ECO:0000269|PubMed:34631692}.
Interaction partners:
- Ly-6/neurotoxin-like protein 1
- Secreted Ly6/Plaur domain containing 1
- Lymphocyte antigen 6 family member H.
- Frizzled-8
Sequence:
MEPSPALAWLLLLSLVADCLKAAQSRDFTVKDIIYLHPSTTPYPGGFKCFTCEKAADNYECNRWAPDIYCPRDTRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGYKICTSCCEGNICNLPLPRNDTDATFATTSPINQTNGHPHCVSVIVSCLWVWLGLTL
Protein: E3 ubiquitin-protein ligase AIRP2 (EC 2.3.2.27) (Protein ABA INSENSITIVE RING PROTEIN 2) (AtAIRP2) (RING-type E3 ubiquitin transferase AIRP2) (Q9M022)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses E3 ubiquitin-protein ligase activity in vitro when associated with the E2 enzyme UBC8 in vitro. Plays combinatory roles with AIRP1 in the positive regulation of the abscisic acid-mediated drought stress response. Plays a positive role in abscisic acid- and high salinity-regulated seed germination through the ubiquitin-proteasome-dependent down-regulation of ATP1/SDIRIP1.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:21969385}.
Interaction partners:
- Probable pterin-4-alpha-carbinolamine dehydratase, chloroplastic
- E3 ubiquitin-protein ligase AIRP1
- E3 ubiquitin-protein ligase SDIR1
- RING/U-box superfamily protein
- E3 ubiquitin-protein ligase RHA2A
- RING-H2 finger protein ATL43
- RING-type E3 ubiquitin transferase
- RING-H2 finger protein ATL14
- Probable E3 ubiquitin-protein ligase XERICO
- E3 ubiquitin-protein ligase MPSR1
Sequence:
MRKSFKDSLKALEADIQFANTLASEYPEEYDGGYVQMRLSYSPAAHLFLFLLQWTDCHFAGALGLLRILIYKAYVDGKTTMSLHERKTSIREFYDVLFPSLLQLHGGITDVEERKQKEICDKRYRKKDRTDKGKMSEIDLEREEECGICLEIRNKVVLPTCNHSMCINCYRNWRARSQSCPFCRGSLKRVNSGDLWIYTCSAEIADLPAIYKENLKRLLIYIDKLPLVTSDPNLVPYAPLPR
Protein: Tubulin gamma chain (Gamma-tubulin) (P53378)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. TUB4 is an important spindle pole body component that organizes both cytoplasmic and nuclear microtubule arrays.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Interaction partners:
- Spindle pole body component 110
- Spindle pole body component SPC97
- Spindle pole body component SPC98
- Gamma tubulin complex adapter SPC72
- DASH complex subunit ASK1
- Cell division control protein 31
- Protein STU2
- Spindle pole body component SPC42
- Cell division control protein KAR1
- Dynein heavy chain, cytoplasmic
Sequence:
MGGEIITLQAGQCGNHVGKFLWSQLAKEHAIGTDGLSQLPDSSTERDDDTKPFFRENSRNKFTPRAIMMDSEPSVIADVENTFRGFFDPRNTWVASDGASAGNSWANGYDIGTRNQDDILNKIDKEIDSTDNFEGFQLLHSVAGGTGSGLGSNLLEALCDRYPKKILTTYSVFPARSSEVVVQSYNTILALRRLIEDSDATVVFDNASLLNISGKVFRNPNIDLQHTNQLISTIISSVTNSIRFPSYMYSSMSSIYSTLIPSPELHFLSPSFTPFTSDYIHDDIAHKGHSSYDVMLDLLDPSNSLVSTAMNNPTYFNVYNTIIGNVEPRQISRAMTKLQQRIKFPSWSSSAMHVNIGRRSPYLPLQPNENEVSGMMLSNMSTVVNVFENACNTFDKVFAKGAFLNNYNVGDLFQSMQNVQDEFAESREVVQSLMEDYVAAEQDSYLDDVLVDDENMVGELEEDLDADGDHKLV
Protein: Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) (O75069)
Organism: Homo sapiens (Human)
Function: May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21593558, ECO:0000269|PubMed:24454821, ECO:0000269|PubMed:30220460}; Multi-pass membrane protein {ECO:0000255}. Note=Concentrates in discrete patches along peripheral endoplasmic reticulum tubules. {ECO:0000269|PubMed:30220460}.
Interaction partners:
- Amyloid-beta precursor protein
Sequence:
MKRCRSDELQQQQGEEDGAGLEDAASHLPGADLRPGETTGANSAGGPTSDAGAAAAPNPGPRSKPPDLKKIQQLSEGSMFGHGLKHLFHSRRRSREREHQTSQDSQQHQQQQGMSDHDSPDEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASLHSSSGGGSSGSSSRRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRSSSTTDTALLLADGSNVYLLAEEAEGIGDKVDKGDLVALSLPAGHGDTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVFVSTIANFITPLMKTRLRITSTTLLVLVLFLLWKHWDSLTYLLEHVLLPS
Protein: Probable GTP-binding protein EngB (P38424)
Organism: Bacillus subtilis (strain 168)
Function: Necessary for normal cell division and for the maintenance of normal septation.
Interaction partners:
- Ribosome biogenesis GTPase A
- Uncharacterized protein YqeH
- GTPase Der
- GTPase Obg
- Small ribosomal subunit biogenesis GTPase RsgA
- Large ribosomal subunit protein bL17
- Putative TrmH family tRNA/rRNA methyltransferase YacO
- Large ribosomal subunit protein uL3
- 23S rRNA
- tRNA modification GTPase MnmE
Sequence:
MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLINRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITTREELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVRQTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR
Protein: Trem-like transcript 4 protein (TLT-4) (Triggering receptor expressed on myeloid cells-like protein 3) (Triggering receptor expressed on myeloid cells-like protein 4) (Q3LRV9)
Organism: Mus musculus (Mouse)
Function: Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs). Does not bind nucleic acids. May participate in antigen presentation.
Subcellular location: Cell membrane {ECO:0000305|PubMed:19155473, ECO:0000305|PubMed:22210914}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- CMRF35-like molecule 2
- Trem-like transcript 1 protein
Sequence:
MAWRYSQLLLVPVQLVFLASVCCPGVWGSTVSEELHRMVGQSLSVQCQYKPKEESYVLKTWCRQTAPSKCTRVVTTSEPRKAARELQHTIWDDPEAGFFNITMTQLTEDDSAFYWCGPYYPSLREVTVLRNISLVVSPAPSTLPSQTIAPLPESTATIFMPFPVLTTSPEETTDSSINGTGHRNQSSSSPGWTSPGLLVSVQYGLLLLKALMLSVFCVLLCWRSGQGREYMAETMELSKLPHISKSLDTVSHISGYEKKANWY
Protein: Calcium-binding protein 4 (CaBP4) (P57796)
Organism: Homo sapiens (Human)
Function: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19338761}. Presynapse {ECO:0000250|UniProtKB:Q8VHC5}. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors. {ECO:0000250|UniProtKB:Q8VHC5}.
Interaction partners:
- Voltage-dependent L-type calcium channel subunit alpha-1F
- Protein S100-G
- Nyctalopin
- Metabotropic glutamate receptor 6
- Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Probable G-protein coupled receptor 179
- C-terminal-binding protein 2
- Protein S100-A6
- Sodium/potassium/calcium exchanger 1
Sequence:
MTTEQARGQQGPNLAIGRQKPPAGVVTPKSDAEEPPLTRKRSKKERGLRGSRKRTGSSGEQTGPEAPGSSNNPPSTGEGPAGAPPASPGPASSRQSHRHRPDSLHDAAQRTYGPLLNRVFGKDRELGPEELDELQAAFEEFDTDRDGYISHRELGDCMRTLGYMPTEMELLEVSQHIKMRMGGRVDFEEFVELIGPKLREETAHMLGVRELRIAFREFDRDRDGRITVAELREAVPALLGEPLAGPELDEMLREVDLNGDGTVDFDEFVMMLSRH
Protein: Muscarinic acetylcholine receptor M5 (P08912)
Organism: Homo sapiens (Human)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Interaction partners:
- Metabotropic glutamate receptor 5
- Muscarinic acetylcholine receptor M3
- Guanine nucleotide-binding protein G
- Muscarinic acetylcholine receptor M1
- Guanine nucleotide-binding protein G
- Kininogen-1
- Guanine nucleotide-binding protein subunit alpha-11
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
Protein: C3H1-type domain-containing protein (Q388W9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSQDNRAKYVQNGVMEVFDPNFKYLYLVPAHFVLHVPPARLNISRLVICRNYRSGVPNSCAKEESCRFVHADVDYSTLEAHPIHVNYIWRHEDHCTYERLPAGDVLEVCSQENPQEHELISSELVLVTRGSVAHHNALPHSLMRCPLYTTNRMCSRGERCSFIHTLCVDPTVVGDFKRAPARTAAVTPTPRSPAVASATDSQKMPRTFASGTPMLSDFCISSPEREAPALSMGAGGYTALSFRVDAAGEPLPATCSVIPRCRVTARVRTSTVVKSRPTLVAAFSDASVSRRSAMATNSRPASYCHNPYYPVLCRS