wanglab/gogpt-training-data huggingface dataset:
Protein: Homeobox protein SIX2 (Sine oculis homeobox homolog 2) (Q9NPC8)
Organism: Homo sapiens (Human)
Function: Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. May also be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q62232}.
Interaction partners:
- Protein phosphatase EYA1
- Protein phosphatase EYA2
- Protein phosphatase EYA3
- Sal-like protein 1
- Protein phosphatase EYA4
- Cbp/p300-interacting transactivator 1
- Paired box protein Pax-2
- Forkhead box protein D1
- Wilms tumor protein
- Protein Wnt-9b
Sequence:
MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENNENSNSNSHNPLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHGLQDSILNPMSANLVDLGS
Protein: Ribonuclease (EC 3.1.-.-) (P84867)
Organism: Pleurotus ostreatus (Oyster mushroom) (White-rot fungus)
Function: Has ribonuclease activity towards yeast tRNA, polyadenine, polycytosine and polyguanine, but lacks ribonuclease activity against polyuracil. Has antiproliferative activity towards L1210 tumor cell line with an IC(50) of 41 uM. Lacks mitogenic activity towards murine splenocytes and does not inhibit HIV-1 reverse transcriptase.
Interaction partners:
Sequence:
VRPYLVAFYESH
Protein: Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) (Q9HB71)
Organism: Homo sapiens (Human)
Function: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Subcellular location: Nucleus {ECO:0000269|PubMed:12895292}. Cytoplasm {ECO:0000269|PubMed:12895292}. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
Interaction partners:
- E3 ubiquitin-protein ligase SIAH1
- S-phase kinase-associated protein 1
- Protein S100-A6
- Catenin beta-1
- Glycogen synthase kinase-3 beta
- Axin-1
- Glycogen synthase kinase-3 alpha
- Adenomatous polyposis coli protein
- Heat shock protein HSP 90-alpha
- E3 ubiquitin-protein ligase NRDP1
Sequence:
MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF
Protein: Metal transporter cnnm-3 (CNNM family homolog 3) (A0A131MCZ8)
Organism: Caenorhabditis elegans
Function: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:27564576}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable GMP synthase
Sequence:
MSKTPWALGLLIFLLTFTSPLSSSPVRSTDNSTSSKGLLNVNSSVILEPSILPSSASKPESLHLSKVRVSGLRLEAHASSTENIVLGHNKKHNVVVVPNKNVRVVLFGQNFQDIGALTFTADGSCKDLAHFFEADFSSMTPIRVVVEMSFPKTTESKDSFKLCVSEKFYANPQFVIVEDPFTMVTTEIPPVDEYMPKWLSWICLLILLCFSGLFSGLNLGLMTLSPYELQLYIASGTEQEKRDAGRILPIRKKGNQLLCTLLIGNVVVNVGVSLLMDQLVGSGFAVLVAATSCIVVFGEIIPQALCVKLGLPIGARTIPITQVLLFLMYPLTWPISKVLDIFLKEELTRSLERNKLVEMLKLSEKSIIGGQSDEFKMVLGALELYDKTVAHAMTRYEDIFMLPHTLTLGAGMVTQILDMGYTRIPIYENDRKNIVALLFVKDLALLDPDDNHNVMKIASIYNHEVRRVLVDMPLRNMLEEFKRGEYHMALVERLVEQEDKDPIYELCGLITLEDIIEEIIQCEIIDETDAVCDNVHRKKRQRKRNHDMSQIVNTAHAKCAINIQMLAVTIQVMSTCHKIFSSNYILPTILEKLIRKNCKKVETTQFSCLKEVGVVQPKPAVLFTKGEFSNKFIMILSGRAVVTIGKEEMRLEAGAWHSFGTEVLDAMAEAIERSLNQSTSRSTVSLNTEITNNSIGFIPDFDTVILYECVFCEITAADLLLAYNSSQIMQNNTKMQVVRSNSRISLIEEIPKDAVSTPIRNGSVKLRTVSEGETVHLLPKNMECHFNKQEKYEEEEE
Protein: Actin, putative (Q386C6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cofilin/actin depolymerizing factor, putative
- Uncharacterized protein
- Tubulin alpha chain
Sequence:
MVCSTERAPVVILDGGSHHLRAGYASDGAPRLDIPALVGHPRNRGVAVAAGMNEYEIGDVALAKRGMLTVSSPIESGRVVSWENMEKLWGHVMYSELRVRPESHCFIVPQSVNTPASQKEKTLELMMETFHVHSLFLGASQVLSLYSYGLTTGLVIDSGKDRTMAVPVHEGYALGRHVAESDVAGEKLTEYFASLLRLEGYSFGTPMEMQVLNNAKEDLCYVKPPIFNMTGPSAFFSPSEFPGECDYDLSLEGAPGEGFEDGREDHSSDERVFYLPDGNAIPISTHRSLTTEALFDFGILGSQYVPKSRYMTELGEIFQPSFPMGVSWLAFAAINNCQPVIRAQLYASIVLSGGNVSFPGTRERIETEVTQLYRETHTSEAVTPIAVNDIPCRVYSAWVGGSMLAGTSMFPHLAVSRQEYEEQGHRVVHCKCQ
Protein: DNA-binding transcription factor (Q5A766)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Transcriptional regulator ADR1
- 5'-AMP-activated protein kinase subunit gamma
Sequence:
MSIKLEQQQSSVSQENNLPPTKKKTKALKSSDGTVNTRTIKVPGSKVERVAQACDRCRAKKTKCDGQNPCSTCQSVGLECIVSDRLTRKSYPKAYTETLEERVRQLEAENKKLAGLLDMRDEQLELLNGSGLTEDTSEMSENKEDDFKKVTASNLSLLDIQNSLHSHSPNENGENCPCGCSNPHAVHERPVSIAGSIYGAVAANERVPISIAGSIKLSDEEDEEDNASLLSIEDYNSRHRDQHFHFASNSTNREQSPAPGAFAAATAIAQMQKNKLFLQQQQQLENENNKQQMLTSLVAMSIPRSTEETLCVPTLLARICQTYGYDSKQAILAANSLASLKENITSNTGTSLDEERKNALNSMIMNRYETTKLSEEEAIVFTKDLINLPASRLDMDQLITVYFQEWGNALPILDKNAFLKNYMKLNYILEQGHYKEYKGESSYESIEKFGAILILVLCLAFHISKKNYLESFNPQIQSRFVTLLQHYGYLIHEFIKPNCLITQYCSIQSLQILSLALQYCLVTGDTASCYELRGRVISMAQQLRLHRCPAAVLGLSGNKEGDIDLQNFMQGERRILFWCIYCLDVYSSLNLGIPRLFKDYEIECAMPFCGKSDDYDDVNQEDNVNILIVNNTKLSIVGKVSKMALSVMSYSKVLANILDSIYSRFDNTNIHKKALQRDRMLDCWRRELPLDLKFEIDINGLSLKDSSNNFIEGNIWRNYNKQQLTLIFLYYHAKILIYLPILSRFGNHHNVGLSQKEQLSKGEGDVATIVSSISLIQQSSIQILEVLKYLTSTSSSNILPIPIHIVREQSLLALMVAKGALDYIKGGPLFSNSKQLLLDTMGNLSRDANFDIPGALNRKSFKLFEITILGILGLNINKSMTSGVNMKRKGSSALQPITKTAVERSPTVNLTNNFAASKLKTPTSNTDMVNNNQILKIEQQDPVLSQQQKQTRNISTREISNNGDIELDNSNNYADDIESLEELLNFDPFKVNVNRQMLVNEFVTDGSLGLVPFLEMNNEQLNDSSMLFDKSYNAINERKTTNHDDYISHNDSHFWK
Protein: Transcription factor jun-1 (Transcription factor AP-1 subunit jun-1) (G5ECU7)
Organism: Caenorhabditis elegans
Function: Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:24178943}.
Interaction partners:
- Transcription factor fos-1
- Transcription factor atf-7
- GLH-binding kinase 1
- Stress-activated protein kinase jnk-1
- Stress-activated protein kinase JNK
- Cyclin N-terminal domain-containing protein
- Serine/threonine-protein kinase WNK
- Homeobox protein ceh-18
- Mitogen-activated protein kinase pmk-1
- Transcription initiation factor TFIID subunit 4
Sequence:
MEEDQEEPPSSSTSSESPEVVLKAPKAPTRRRKNSKKDRRQDMEVDDGEKESTAQYCKGFYDALRVMQTTNKYEFTGGAVSSPVLPVLQTAAFSPITPASASDMHTIVMSLLGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTTAVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDSRSASRCGMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV
Protein: Receptor expression-enhancing protein 5 (Q6PBX9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q60870}; Multi-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q60870}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Reticulon.
- Reticulon
- Reticulon
- Reticulon
- Reticulon
- Reticulon
Sequence:
MAAALKQRFDNALHEKNMVTDLLAKIEAKTGVNRSYIAYAVIAFIAIYLVIGYGASLLCNLIGFVYPAYISIKAIESPAKDDDTKWLTYWVVYGVFSVVEFFADIFLSWFPFYFLAKCAFLVWCMAPTPSNGSIMLYTRIIRPFFLKNEAKIDNVMKDLTDKAAGAADKIKDEAKKATANIMFEEKKHY
Protein: Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8) (Q5W5X9)
Organism: Homo sapiens (Human)
Function: Participates positively in the ciliary Hedgehog (Hh) signaling.
Subcellular location: Cell projection, cilium {ECO:0000250|UniProtKB:Q8CHY7}. Note=Colocalizes with EVC and IQCE at the EvC zone of primary cilia. {ECO:0000250|UniProtKB:Q8CHY7}.
Interaction partners:
- IQ domain-containing protein E
Sequence:
MQESQETHISNHLDEVVAAVSITHRKKFQNKLLQTALFQPPREKLHLCEEKAKSYSNSHEYKQAVHELVRCVALTRICYGDSHWKLAEAHVNLAQGYLQLKGLSLQAKQHAEKARQILANSIVPPYSENTDVFKFSIELFHTMGRALLSLQKFKEAAENLTKAERLSKELLQCGRIIKEEWIEIEARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQALGLHDVSINHFLQAHLIILSRSPSQVEAADSAHIVAHAAVASGRHEHHDVAEQYFQESMAHLKDSEGMGRTKFLSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKCLQIQTLLYGPQDKRTLATQQAMGMLSTAPKVASKPRQASKAKVAFCTSIPQDTLLGKARPGTTAD
Protein: Antisense of depressing factor protein 1 (Q2V2Q1)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional repressor which negatively regulates transcription of FYV5 by binding to the promoter on the sense strand.
Subcellular location: Nucleus {ECO:0000269|PubMed:20195295}.
Interaction partners:
- Protein FYV5
- Ammonia regulation of amino acid uptake protein
- Vacuolar morphogenesis protein 10
Sequence:
MGKCSMKKKGVGKNVGVGKKVQKKRSISTAERKRTKLQVEKLNKSSETMIPTLLREASTQEPAKLKAETTLKAEELIKDQEKDSKVREQIRTEKSKTNDSMLKQIEMISGFSL
Protein: KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) (Q91WI7)
Organism: Mus musculus (Mouse)
Function: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q969R8}. Note=Localization to lysosomes is amino acid-independent. {ECO:0000250|UniProtKB:Q969R8}.
Interaction partners:
- KICSTOR complex protein kaptin
- KICSTOR complex protein SZT2
- KICSTOR subunit 2
- GATOR1 complex protein DEPDC5
- GATOR1 complex protein NPRL2
- GATOR2 complex protein WDR59
- GATOR2 complex protein WDR24
- Lysosome-associated membrane glycoprotein 1
- S-adenosylmethionine sensor upstream of mTORC1
- GATOR1 complex protein NPRL3
Sequence:
MRSVSYVQRVALDFSGSLFPHAICLGDVDNDALNELVVGDTSGKLSVYKNDDSRPWLTCMCQGMLTCVGVGDVCNKGKNLVVAVSAEGWLHLFDLTPTKALDASGHHETLGEEQRPVFKQHIPANTKVMLISDIDGDGCYELVVGYTDRVVRAFRWEELAEGPEHLAGQLVSLKKWMLEGQVDSLSVTPGPLGVPELVVSQPGCAYAVLLCTWNKDTGSPPASEEATGDSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIRQGHNPEGGNAGLFALCTLDGTLKLMQEADKLLWSVQVDHQLFALEKLDVTGNGLEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGQYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLLKLLEAEPEYHRLLQELRVDPEDLPAVCTLLHQTLYHPDQPLQCTPSSFQDPT
Protein: Transforming growth factor beta activator LRRC33 (Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species) (Q8BMT4)
Organism: Mus musculus (Mouse)
Function: Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:24739962, ECO:0000269|PubMed:29909984}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24739962}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
Sequence:
MEFPPLWLCLGFHFLIVEWRSGPGTATAASQGGCKVVDGVADCRGLNLASVPSSLPPHSRMLILDANPLKDLWNHSLQAYPRLENLSLHSCHLDRISHYAFREQGHLRNLVLADNRLSENYKESAAALHTLLGLRRLDLSGNSLTEDMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLCPQMVPVDWEGPPSCVDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGVLNGSISPLWAVAPTLQVLSLRDVGLGSGAAEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQQHFKTVADLSMVTCNLSSKIVRVVELPEGLPQGCKWEQVDTGLFYLVLILPSCLTLLVACTVVFLTFKKPLLQVIKSRCHWSSIY
Protein: Exocyst complex component 5 (Exocyst complex component Sec10) (B0G163)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Interaction partners:
- Exocyst complex component 7
- Exocyst complex component 3
- Exocyst complex component 4
- Exocyst complex component 8
- Exocyst complex component 6
- Exocyst complex component 2
- Exocyst complex component 1
- Protein transport protein sec1
Sequence:
MSWARNIQSRIQQQQQLQKPGGLAPPSGNETPQKQPSSPTLSALSSPITSLTNALRGSGGISQPTTNTTSLTSTSPPSPTISTTTTQVKVGQTSFTTSTNLQAAASGNNLQASIQTTNITVTSPSMASPIGTSTGIQNPNAKPSSLPSPSQSPMQTRNTSAPTNNNNNNNTATTTTPTTTTTTTTTTTTTTTTTTTPSTSTTTTPTTSSSNLGQIQQQPPTLQQQQQQIQQQQQQQPTPIKQTTPYIFPNKIQPKSLTTDMFRGSEFSHVTFVEDLTRKLVNDQMGADGLHFEPAPFNQLFLNTQLQLSQLESNIDRRLDDLAEECNDFSYDYKRKLQDLTGSYQECFQHFKKLEKGVNTIGTKAVHFGDELDSVNQQKVKAQGALSLINYLLELNSVGASSEENGGITKRSDIFTNSDRIHELAHLVKKLSSVSEDIKEISGFKQGKLETESISNSLENDLLNQFERAAERNDYDKMKQCATTLHGFNGGERCRSRYIQKLKMFFDIDSFRKDENLANNITKRLIRGNNIVDTRFEIFYTDILKDVSHEQMVIQNVFVNQTSAMAMLIIRLFEQRVRLFIENVLSLESNNVSMFLQTVHYAFNSTKKLLVDPLQSYGIVGVDLNQLLNSIFYQYQEGYIQKETTYLVSLFQSNVVEECERLQTLDRYSMYLEDGLNPEITQMFVQQTENALTRSYTLSLDNILADNIKTIFFLMLEYLFEKYSMFVLNKYIELPMIPSSSSNVDTKSIQDSISQLFRVVLSINQIVGQIQSMFQVFVLPHIQTSMIVQSQCSDQLYFNISSLENTINTGLENSLTTMIQLIEKTLLPQGRNDYLIDDYDNSVTDTCASVIKLIQSFYDMAKINLQGKNFHIYVEELGLKSQFVFINHFKKFKIGQGIGTLKLMRDLTEYRNLSKQFKSQKVDDAFELLFEISKLHLVNPENFKLVIEGGALTRMSKQDLIIFIKQRSDFKSIWLDTL
Protein: Beta-crystallin A4 (Beta-A4 crystallin) (P56374)
Organism: Rattus norvegicus (Rat)
Function: Crystallins are the dominant structural components of the vertebrate eye lens.
Interaction partners:
- Alpha-crystallin A chain
- Filensin
- Alpha-crystallin B chain
- Grifin
- Gamma-crystallin A.
Sequence:
MTLQCTKSAGHWRVVVWDEEGFQGRRHEFTAECPSVLDLGFETVRSLKVLSGAWVGFEHAGFQGQQYVLERGDYPGWDAWGGNTAYPAERLTSFRPVACANHRDSRLTIFEQENFLGRKGELSDDYPSLQAMGWDGTEVGSFHVQSGAWVCSQFPGYRGFQYVLESDHHSGDYKHFREWGSHAHTFQVQSVRRIQQ
Protein: Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) (Q00566)
Organism: Rattus norvegicus (Rat)
Function: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Subcellular location: Nucleus {ECO:0000269|PubMed:16670375}. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. {ECO:0000250|UniProtKB:P51608}.
Interaction partners:
- Histone deacetylase 1
- Paired amphipathic helix protein Sin3a
- Histone deacetylase 2
- Nuclear receptor corepressor 1
- DNA
- Cyclic AMP-responsive element-binding protein 1
- Histone-lysine N-methyltransferase
- Delta
- Transcriptional regulator ATRX
- Transcriptional regulator ATRX.
Sequence:
MVAGMLGLRKEKSEDQDLQGLKEKPLKFKKVKKDKKEDKEGKHEPLQPSAHHSAEPAEAGKAETSESSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTGRPKAAASEGVQVKRVLEKSPGKLLVKMPFQASPGGKGEGGGATTSAQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHAESPKAPMPLLPPPPPPEPQSSEDPISPPEPQDLSSSICKEEKMPRAGSLESDGCPKEPAKTQPMVAAAATTTTTTTTTVAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS
Protein: Uncharacterized protein (O53298)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- HTH-type transcriptional regulator VirS
- ESX-1 secretion system protein EccD1
- Uncharacterized protein Rv2209
- PPE family protein PPE8
- PPE family protein PPE55
- PE-PGRS family protein PE_PGRS28
- PPE family protein PPE56
- PE-PGRS family protein PE_PGRS43
- Probable membrane protein
- PPE family protein PPE34
Sequence:
MTPHYRQAAASRLDTHRTQKLRSQTNGGKDRHQLTYEQFARMLTLMGPSDLWTVERAARHWGVSASRARAILSSRHIHRVSGYPAQAIKAVTLRQGARTDLKTANHLVPAAQAFTMAETGAAIGETEDERARLRIFFEFLRGADETGTSALDLIVDEPALIGEHRFDALLAAAAEYISARWGRPGPLWSVSIERFLDTAWWVSDLPSARAFAAVWTPAPFRRRGIYLDRHDLTSDGVCVMPEPVFNRTELQRAFTALAAKLERRGVVGQVHVVGGAAMLLAYNSRVTTRDIDALFSTDGPMLEAIREVADEMGWPRTWLNNQASGYVSRTPGEGAPVFDHPFLHVVATPAQHLLAMKVVAARGVRDGEDIRLLLDRLRITSAAGVWEIVARYFPAETITDRSRLLVEDLLNQ
Protein: Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8) (P85298)
Organism: Homo sapiens (Human)
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Interaction partners:
- Proline-rich protein 5
- Endophilin-A2
- Endophilin-A3
- Endophilin-A1
- PRR5-ARHGAP8 readthrough
- Cell division control protein 42 homolog
- Transforming protein RhoA
Sequence:
MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSSHLSLPKYWDYRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL
Protein: Histone demethylase JHD2 (EC 1.14.11.67) (Jumonji/ARID domain-containing protein 2) ([histone H3]-trimethyl-L-lysine(4) demethylase JHD2) (P47156)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated H3 'Lys-4'.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
Interaction partners:
- Histone H3
- ATP synthase subunit gamma, mitochondrial
- ATP synthase subunit alpha
- ATP synthase subunit a
- ATP synthase subunit 5, mitochondrial
- ATP synthase subunit delta, mitochondrial
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- ATP synthase subunit d
- ATP synthase subunit 4
- JmjC domain-containing histone demethylation protein 1
Sequence:
MEEIPALYPTEQEFKNPIDYLSNPHIKRLGVRYGMVKVVPPNGFCPPLSIDMENFTFQPRIQNLENLDLKNRCRLFFMKQLNNFKRSVKDPSKLILREPYTIVEYSDSTHASEILKKKVYFYDVFSELIKDNRTLTDTTQSFRRKLKFRDISQLRGDISLWRTISKKFNVPIGLLKEIFEKYIASYYIFLHSLNENVHTALHADQYPKSLLSDDEDDFDLGPDSNSGSDFEEDDDDACIVCRKTNDPKRTILCDSCDKPFHIYCLSPPLERVPSGDWICNTCIVGNGYYGFTQDTHDYSLPEFQEYCKRQNSRLLPARKLSIDELEEMFWSLVTKNRRSSLTTVKYGADIHNELPGQITGFPTREFIPKNINGDELIDYLKYCDHPMNLTNLPMAHNSLLPLFKRNISGMTIPWIYIGSLFSTFCWHMEDQYTLSANYQHEGDPKVWYSIPESGCTKFNDLLNDMSPDLFIKQPDLLHQLVTLISPYDPNFKKSGIPVYKAVQKPNEYIITFPKCYHAGFNTGYNFNEAVNFTIDFWLPYGFGAITDYKLTQKACVFDMFDLMINVLDKYNKDTLLFNDAFVRQCYSSLIVFYNTELKRIRKIQAIVPRTTLLEVHTDPNDEDEEYDIFCSQCKTICSIAFVLRKNNYDSIRTYKRHKKNHLSIRQWNELSTTDSKVSILCTQDYLKSIQNLNNSDGEEPYIDDELYFTKSLKDIDSLIKQVGVKLDR
Protein: Disease resistance protein Roq1 (2' cyclic ADP-D-ribose synthase) (2'cADPR synthase Roq1) (EC 3.2.2.-) (NAD(+) hydrolase RPV1) (EC 3.2.2.6) (Recognition of XopQ 1 protein) (A0A290U7C4)
Organism: Nicotiana benthamiana
Function: Disease resistance (R) protein that specifically recognizes the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1, and triggers cell death. Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death.
Interaction partners:
Sequence:
MLTSSSHHGRSYDVFLSFRGEDTRKTFVGHLFNALIEKGIHTFMDDKELKRGKSISSELMKAIGESRFAVVVFSKNYASSTWCLEELVKILEIHEKFELIVVPVFYDVDPSTVRKQNGEYAVCFTKFEANLVDDRDKVLRWREALTKVANISGHDLRNTYNGDESKCIQQILKDIFDKFCFSISITNRDLVGIESQIKKLSSLLRMDLKGVRLVGIWGMGGVGKTTAARALFNRYYQNFESACFLEDVKEYLQHHTLLYLQKTLLSKLLKVEFVDCTDTEEMCVILKRRLCSKKVLVVLDDVNHNDQLDKLVGAEDWFGSGSRIVITTRDMKLLKNHDVHETYEIKVLEKDEAIELFNLHAFKRSSPEKEFKELLNLVVDYTGGLPLALKVLGSLLYKEDLDVWISTIDRLKDNPEGEIMATLKISFDGLRDYEKSIFLDIACFFRGYNQRDMTALFHASGFHPVLGVKTLVEKSLIFILEDKIQMHDLMQEMGRQIAVQESPMRRIYRPEDVKDACIGDMRKEAIEGLLLTEPEQFEEGELEYMYSAEALKKTRRLRILVKEYYNRGFDEPVAYLPNSLLWLEWRNYSSNSFPSNFEPSKLVYLTMKGSSIIELWNGAKRLAFLTTLDLSYCHKLIQTPDFRMITNLERLILSSCDALVEVHPSVGFLKNLILLNMDHCISLERLPAIIQSECLEVLDLNYCFNLKMFPEVERNMTHLKKLDLTSTGIRELPASIEHLSSLENLQMHSCNQLVSLPSSIWRFRNLKISECEKLGSLPEIHGNSNCTRELILKLVSIKELPTSIGNLTSLNFLEICNCKTISSLSSSIWGLTSLTTLKLLDCRKLKNLPGIPNAINHLSGHGLQLLLTLEQPTIYERLDLLRIIDMSWCSCISSLPHNIWMLKFLRILCISYCSRLEYLPENLGHLEHLEELLADGTGILRLPSSVARLNKLEVLSFRKKFAIGPKVQYSSSMLNLPDDVFGSLGSLGSVVKLNLSGNGFCNLPETMNQLFCLEYLDITFCQRLEALPELPPSIKELYVDEHLALRIMEDLVIKCKELNLIAVTKIEYQNFYRWLDSIWSDVSELLENSQKQQLDDMLQLIPFSYLSTAKREEVLKIVIHGTRIPEWFRWQDRSATTMSVNLPEYWYTENFLGFAICCSCCFYHSARSYDVEFEGSMHHYNYDSSYWKEYEEPSYDFYERDSIEITAKLTPRHKGMRTEELKKVCSFSMNVLRRATAVPNMCFAFFPFNSLCHISNLQANNPNDYGIFETCLSPGDIRHRGKQWGFNLVYKDETGGSVTHEMLINR
Protein: Lectin-like transmembrane protein (Q6DUV0)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSEQEVTYSTVRFHKSSGLQNQVRPEDNQGSREAGHKECSIPWHLIVIAFGILCVLLLVIVAVLVTNILQYKQEKHELQETLNCHHNCSTMQSDINAKEEMLRNMPLECSTGDDLLKSLNREQKRWYSETKSVLNSSKHPGGSLEIHWFCYGIKCYYFIMNKKGWHKCKQICEHYSLSLLKIDAEDELKFLQLQVTPDSYWIGFSFDKKSEKWTWIENGTSKYALNMSTYNVKSGECVFLSKTRLENNKCEHVYPCICEKRLDKFPDSLPNNS