wanglab/gogpt-training-data huggingface dataset:
Protein: Tenascin C (A0A8I6GHT4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MGAVTWLLPGIFLALFALTPEGGVLKKVIRHKRESGLNLTLPEENQPVVFNHIYNIKLPMGSQCSVDLESTSGEKDLSPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELEMLVSSLREQCTMGTGCCLQPAEGRLDSRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPECPGNCNLRGQCLDGQCICDQGFTGEDCSQLACPNDCNDQGKCVNGVCVCFEGYAGLDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCFNNCNNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNNCQGHGQCEEGQCVCNEGFAGADCSEKRCPADCHHHGRCLNGQCECDDGFTGADCGELQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGHCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGSDCAELSCPGDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVAGRCICNEGYTGVDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSQIEVRDITDTTALITWSKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLKPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGVGVSAVKGDKEGDPATINAATEIDAPRDLQVSETTQDSLTLFWKTPLAKFDRYRLNYSLPTGQSIEIQLPKDATSHVLTDLEPGQEYTVLLTAEKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLRLNWTADDLAYEYFVIQVQEANKVETAHNFTVLGNLRTADIPGLKAATPYRVSIYGVARGYKTPVLSAETFTGKTPSLGEVTVAEVGWDALKLNWTAPEGAYTNFFIQVLEADMTQTVQNLTVPGGLRSVDLPGLKAATRYYITVRGVTQDFSTAPLSVEVLTAKEPEIGNLNISDVTPESFNLSWTATDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIVYLSGIAPSIRTKTISTTATTEAEPEVDNLLVSDATPDGFRLSWTADEGIFDSFVIRIRDTKKQSEPQEITLPSPDRTRDITGLREATEYEIELYGISRGRRSQPVSAIATTAMGSPKEIMFSDITENAATVSWRAPTAQVESFRITYVPVTGGPPSMVTVDGTDTETRLVRLTPGVEYHVSVIAMKGFEESDPVSGSLITALDGPSGLLTANITDSEALAMWQPAIATVDSYVISYTGERVPEITRTVSGNTVEFELHDLEPATEYTLSVFAEKGHQKSSTIATKFTTDLDSPRELTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTARIQALSGSLRSKLIQTIFTTIGLLYPFPRDCSQAMLNGDTTSGLYTIYINGDKTQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGLDNLSKITAQGQYELRVDLQDHGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCALSYKGAFWYKNCHRVNLMGRYGDNNHSQGVNWFHWKGHEYSIQFAEMKLRPSNFRNLEGRRKRA
Protein: KEP1 (Q9TZN6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
METPSEFTEKQPPTHDHQPRLNEVAQKFLADLDEERQLWSADFPLCALLIDEAVDRVYCTGRIPGKEFYADVYKQKPMKITQKVFVPVKQYPKFNFTGKILGPKGNSLRRLQEETQCKIAIKGRSSIRDRNKEEQLRSTGDPRYAHLQKDLFLEVSTVATPAECYARIAYALAEIRKYLIPDKNDEVSHEQLRELMEMDPESAKNIHGPNLEAYRSVFDKKFGGNSNGAPKYINLIKRAAENPPEVDDVEEVAYEYEHRMPPKRPPTGYEYSKPRPSIIPTNAAAYKRPYPTDMKRMREPPIKSYKPNPYTILKKYK
Protein: 5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1) (Q9JM14)
Organism: Mus musculus (Mouse)
Function: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10681516}.
Interaction partners:
- Cytosolic 5'-nucleotidase 1A
- Cytosolic 5'-nucleotidase 3A
- Cytosolic purine 5'-nucleotidase
- 7-methylguanosine phosphate-specific 5'-nucleotidase
- Cytosolic 5'-nucleotidase 1B
- Deoxyuridine triphosphatase.
- Thymidylate kinase
- Thymidine kinase 2, mitochondrial
- Deoxycytidine kinase
- Thymidine kinase, cytosolic
Sequence:
MAVKRPVRVLVDMDGVLADFESGLLQGFRRRFPEEPHVPLEQRRGFLANEQYGALRPDLAEKVASVYESPGFFLNLEPIPGALDALREMNDMKDTEVFICTTPLLKYDHCVGEKYRWVEQNLGPEFVERIILTRDKTVVMGDLLIDDKDNIQGLEETPSWEHILFTCCHNQHLALPPTRRRLLSWSDNWRGIIESKRASL
Protein: Photosystem II D2 protein (PSII D2 protein) (EC 1.10.3.9) (Photosystem Q(A) protein) (P0C436)
Organism: Oryza sativa subsp. indica (Rice)
Function: Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01383}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01383}.
Interaction partners:
- Photosystem II CP43 reaction center protein
- Photosystem II CP47 reaction center protein
- Cytochrome b559 subunit alpha
- Cytochrome b559 subunit beta
- Photosystem II protein D1
- Cytochrome b6-f complex subunit 4
- Photosystem II reaction center protein H
- Cytochrome b6
- Complex 1 LYR protein domain-containing protein
- HMA domain-containing protein
Sequence:
MTIALGRVTKEENDLFDIMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFALIGFMLRQFELARSVQLRPYNAISFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSAIGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
Protein: Frizzled class receptor 7a (Frizzled homolog 7a) (Frizzled-7a precursor) (Q6NV44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Protein Wnt-11
- Glypican 4
- Protein Wnt-5b
- Protein Wnt
- Tyrosine-protein kinase RYK
- E3 ubiquitin-protein ligase znrf3
- Protein Wnt-2
- Protein Wnt
- Protein Wnt
- Low density lipoprotein receptor-related protein 5
Sequence:
MAFLKMQHCCGITRYFLLLFTVALQTTSGQYHGEKGISIPEHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSMDLKFFLCSMYAPVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAGSPTSNPTPYVPELITLQPNLVVRPNQQFTCPLQLKVPTYLKYHFMGEKDCGAPCEPTRPNGLMYFREEEVKFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGFFLEDKVVCIDKFSDDGYKTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDMLTGVCYVGIYNVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTWHMQTCKRFAVPCPVNNFAPMSPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKRLSNSNQGETTV
Protein: T3SS component (B7UMA5)
Organism: Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Interaction partners:
Sequence:
MLDRILSIRKSRANRLRESMAKINSQIKEVDGKLDDCEQSIKESIASKQAYCASLVNLDKVSLYKYQIKNNAFDEQKQRLYEKKSSLSKEKRSLLDSQKRTKENLQHVNKSVEKLSFAIKEHYFD
Protein: Protein SSD1 (Protein SRK1) (P24276)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Can suppress the lethality due to deletion of SIT4, and partially the defects due to BCY1 disruption. Is implicated in the control of the cell cycle G1 phase.
Interaction partners:
- Exosome complex exonuclease RRP6
- Exosome complex component SKI6
- Exosome complex component RRP46
- Exosome complex protein LRP1
- Exosome complex component CSL4
- Exosome complex component RRP43
- Exosome complex component RRP45
- Exosome complex component RRP4
- Exosome complex component RRP40
- Exosome complex component RRP42
Sequence:
MSKNSNVNNNRSQEPNNMFVQTTGGGKNAPKQIHVAHRRSQSELTNLMIEQFTLQKQLEQVQAQQQQLMAQQQQLAQQTGQYLSGNSGSNNHFTPQPPHPHYNSNGNSPGMSAGGSRSRTHSRNNSGYYHNSYDNNNNSNNPGSNSHRKTSSQSSIYGHSRRHSLGLNEAKKAAAEEQAKRISGGEAGVTVKIDSVQADSGSNSTTEQSDFKFPPPPNAHQGHRRATSNLSPPSFKFPPNSHGDNDDEFIATSSTHRRSKTRNNEYSPGINSNWRNQSQQPQQQLSPFRHRGSNSRDYNSFNTLEPPAIFQQGHKHRASNSSVHSFSSQGNNNGGGRKSLFAPYLPQANIPELIQEGRLVAGILRVNKKNRSDAWVSTDGALDADIYICGSKDRNRALEGDLVAVELLVVDDVWESKKEKEEKKRRKDASMQHDLIPLNSSDDYHNDASVTAATSNNFLSSPSSSDSLSKDDLSVRRKRSSTINNDSDSLSSPTKSGVRRRSSLKQRPTQKKNDDVEVEGQSLLLVEEEEINDKYKPLYAGHVVAVLDRIPGQLFSGTLGLLRPSQQANSDNNKPPQSPKIAWFKPTDKKVPLIAIPTELAPKDFVENADKYSEKLFVASIKRWPITSLHPFGILVSELGDIHDPDTEIDSILRDNNFLSNEYLDQKNPQKEKPSFQPLPLTAESLEYRRNFTDTNEYNIFAISELGWVSEFALHVRNNGNGTLELGCHVVDVTSHIEEGSSVDRRARKRSSAVFMPQKLVNLLPQSFNDELSLAPGKESATLSVVYTLDSSTLRIKSTWVGESTISPSNILSLEQLDEKLSTGSPTSYLSTVQEIARSFYARRINDPEATLLPTLSLLESLDDEKVKVDLNILDRTLGFVVINEIKRKVNSTVAEKIYTKLGDLALLRRQMQPIATKMASFRKKIQNFGYNFDTNTADELIKGVLKIKDDDVRVGIEILLFKTMPRARYFIAGKVDPDQYGHYALNLPIYTHFTAPMRRYADHVVHRQLKAVIHDTPYTEDMEALKITSEYCNFKKDCAYQAQEQAIHLLLCKTINDMGNTTGQLLTMATVLQVYESSFDVFIPEFGIEKRVHGDQLPLIKAEFDGTNRVLELHWQPGVDSATFIPADEKNPKSYRNSIKNKFRSTAAEIANIELDKEAESEPLISDPLSKELSDLHLTVPNLRLPSASDNKQNALEKFISTTETRIENDNYIQEIHELQKIPILLRAEVGMALPCLTVRALNPFMKRV
Protein: Kinteoplast poly(A) polymerase complex 1 subunit (Q381K1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Small ribosomal subunit protein mS41
- tRNA pseudouridine synthase A-like protein
- 30S ribosomal protein S8, putative
- Uncharacterized protein
- Uncharacterized protein
- Ribosomal protein S9
Sequence:
MRHTIPFFRRSAFVPAPGSSLLNPRSQRAKVRRMVAAQKAQGENFERQALYAELGGSPSARAPRSKGERSKEATRRVGCEVAERAKHMTDAEWEGVPVDEKHAFAKYMHKVLQEHPTETTEQQRRRYFETTMADVFELDPRKTVRDEYERVKLGLPVHLKNPQYSLGVSQAVYDAADASLFDPENVHRLENAMTHVKQVFADYVHKKREGVSTEAERRMLANLTAELNLETQKHLANMFKYAEMRLRQVKLEERHHQLAEIERLRRMAQQRGGVKGRKGGSRKMSRMERLKRVINRAVGLDIAVAETVLTEMQAQEEFLQFCEVFARLTLGSGFKHTGKDENLSAYIESLRKLYSMDAATLSTLDVVQYYSSKEGAHPVDWAKRWYERALLLPLQSTPEYQKLLQIQQRDESTVKHIKETAGTGHAFACEAEAEVARIKTQKVVNLVEKMFMDPKDKRLESLHEKRLRYLAHMQMERQIRCVRENAKLFDGVENMPEAAQCRELYEKIMEKKTAQCNMTSPPEGEGSAIQSAKTEGDHCEVGPGMFNVYDDAEASSLFEKIREITLRVIRDRHVQSAAATKARMLNRIIRSLKGGEQSIAEELRALHQQRKEKMTMRILGIIENDVKTEMEWLQNMEEAERPPLLPIPENMSYVSAADVQAWRELREDDERKAANPFERRRRTFQPELLGQAWSVPNKPLLFWGTGVSAVQQALRHVAEDAERKRQGLLLAPPYPCAENPWGWRLAKDILDDNN
Protein: Ubiquitin (C0H4U7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- NEDD8-activating enzyme E1 catalytic subunit
- Ubiquitin carboxyl-terminal hydrolase UCHL3
- NEDD8-conjugating enzyme UBC12, putative
Sequence:
MIKKVHICLFIIFFYVIFLIHICKGIRLQNYKNERINNRHMLNTIRNNVSIYQNKHISNNNTKENKCNIMINYYDKSNIFCKSFLLSMEEKDNIKNIKKKIEEIYGIPLTLQEILYDNKKLENNITIQNIIKDKQIKILNLRLITILPHLFLQKDDDNNTNKRNDVSSSSSSSSLYNNEYIKSNKRITYLKNKLTYYGYLTLLNEYKKLSHILENKKYILKNDDILESFKSFDQEFEKTLKNNNINLHKIKKEINKLKHIDKKKLLLRLEVDYPLMSNNLTKRIKQLFQYYYMGDITTIIKFSIFFYILYKYADYPNHIKKFFLYLSILFLISPFKPFYKFSHFLFFSVPNNILFSGFTNILSASYQQILMCQ
Protein: Trypanosoma glutamic acid/alanine-rich protein domain-containing protein (Q57YD8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTRFTCFTAVVLLCMPFAVGKNNNLTLEQTVTLCNALKQFRGLKDAVRDLKYWITTESLKISNAKTRSDEYVTLAEDVLWENRNATDPVERAKRVASNVTEAAKKAETASIETEFRAENIEEIRSNRIAALERMLKEVAGHNSNWRVRSAAEKCKGAAESVSSDSLNGTLLELFSTLPEGASEGLEDDTRESSGELWKLEFVLYNVVTWRSVALKGESTVKELVEGTKASITRKYNLTLNQTQAVCLMVEQYRGLKGAVDAFTEQAVSRSAMVSKVEERSQADAKRPGGHMDQVKRAVAEVAKAVSKAQNVFKKVSRYARNLKSIRAHYLPLMENTLRKIAGNAADEKAKKAAEVCGETAWVVTPKSLDDMRKKLMDNFPNLSERLESDTRVVSHMLEDLNTSTQLITIASIAVRRKEVKLNKTMEVAGVASLIEFGEGRLSSMGSAASNKNHNLRLLLFSLTFTLVGLL
Protein: Probable WRKY transcription factor 13 (WRKY DNA-binding protein 13) (Q9SVB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- ABC transporter G family member 36
Sequence:
MGAINQGISLFDESQTVINPINTNHLGFFFSFPSHSTLSSSSSSSSSSPSSLVSPFLGHNSLNSFLHNNPSSFISHPQDSINLMTNLPETLISSLSSSKQRDDHDGFLNLDHHRLTGSISSQRPLSNPWAWSCQAGYGSSQKNNHGSEIDVDDNDDEVGDGGGINDDDNGRHHHHDTPSRHDKHNTASLGVVSSLKMKKLKTRRKVREPRFCFKTLSEVDVLDDGYRWRKYGQKVVKNTQHPRSYYRCTQDKCRVKKRVERLADDPRMVITTYEGRHLHSPSNHLDDDSLSTSHLHPPLSNFFW
Protein: Probable actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) (P58798)
Organism: Caenorhabditis elegans
Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Probable actin-related protein 2/3 complex subunit 3
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit
- Actin-related protein 3
- Probable actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 5
- Probable actin-related protein 2/3 complex subunit 5
- CRIB domain-containing protein
- SPIN90/Ldb17 leucine-rich domain-containing protein
- Structure-specific endonuclease subunit SLX1 homolog
Sequence:
MSATLQPYLEAVRHTLQAALCLEQFSSQVVERHNKPEVEVQTSKELLMTPVVVARNKQERVLIEPSVNSVRISIAIKQSDEIEKILCHKFTRFMCQRADNFFVLRRKPLPGYDISFLITASHTEAMFKHKLVDFLLHFMQEIDKEISEMKLSLNARARVSAEEFLKRFN
Protein: Calcium-transporting ATPase 3, endoplasmic reticulum-type (AtECA3) (EC 7.2.2.10) (Q9SY55)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to an endomembrane compartment (Probable). Involved in calcium-enhanced root growth, in tolerance to toxic levels of manganese and in secretory processes. Has a crucial role in manganese nutrition, but is not involved in transporting copper, iron or zinc.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18024560}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:18567829}; Multi-pass membrane protein {ECO:0000255}. Prevacuolar compartment membrane {ECO:0000269|PubMed:18567829}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Metal tolerance protein 11
- GDT1-like protein 3
- Putative metal tolerance protein C3
- Alpha carbonic anhydrase 2
- Probable metal-nicotianamine transporter YSL4
- Vacuolar cation/proton exchanger 4
- Metal transporter Nramp3
- Metal transporter Nramp2
- Alpha carbonic anhydrase 4
- ATPase GET3C
Sequence:
MEDAYARSVSEVLDFFGVDPTKGLSDSQVVHHSRLYGRNVLPEEKRTPFWKLVLKQFDDLLVKILIVAAIVSFVLALANGETGLTAFLEPFVILLILAANAAVGVITETNAEKALEELRAYQANIATVLRNGCFSILPATELVPGDIVEVTVGCKIPADLRMIEMSSNTFRVDQAILTGESCSVEKDVDCTLTTNAVYQDKKNILFSGTDVVAGRGRAVVIGVGSNTAMGSIHDSMLQTDDEATPLKKKLDEFGSFLAKVIAGICVLVWVVNIGHFSDPSHGGFFKGAIHYFKIAVALAVAAIPEGLPAVVTTCLALGTKKMARLNAIVRSLPSVETLGCTTVICSDKTGTLTTNMMSVSKICVVQSAEHGPMINEFTVSGTTYAPEGTVFDSNGMQLDLPAQSPCLHHLAMCSSLCNDSILQYNPDKDSYEKIGESTEVALRVLAEKVGLPGFDSMPSALNMLSKHERASYCNHYWENQFKKVYVLEFTRDRKMMSVLCSHKQMDVMFSKGAPESIIARCNKILCNGDGSVVPLTAAGRAELESRFYSFGDETLRCLALAFKTVPHGQQTISYDNENDLTFIGLVGMLDPPREEVRDAMLACMTAGIRVIVVTGDNKSTAESLCRKIGAFDNLVDFSGMSYTASEFERLPAVQQTLALRRMTLFSRVEPSHKRMLVEALQKQNEVVAMTGDGVNDAPALKKADIGIAMGSGTAVAKSASDMVLADDNFASIVAAVAEGRAIYNNTKQFIRYMISSNIGEVVCIFVAAVLGIPDTLAPVQLLWVNLVTDGLPATAIGFNKQDSDVMKAKPRKVGEAVVTGWLFFRYLVIGVYVGLATVAGFIWWFVYSDGGPKLTYSELMNFETCALRETTYPCSIFEDRHPSTVAMTVLVVVEMFNALNNLSENQSLLVITPRSNLWLVGSIILTMLLHVLILYVHPLAVLFSVTPLSWAEWTAVLYLSFPVIIIDELLKFLSRNTGMRFRFRLRKADLLPKDRRDK
Protein: Ephrin type-B receptor 4b (EC 2.7.10.1) (Eph receptor B4b) (Eph-like receptor tyrosine kinase rtk8) (O73878)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells (By similarity). Involved in somitogenesis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P54760}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P54760}.
Interaction partners:
- Ephrin-B2b
- Efnb3 protein
- Ephrin-A5b
- Ephrin-B1
Sequence:
MDRVCWIMALSWFWMVSTGLVSAEEEVLMNTKLETSDLRWTIYPSGDPEWEEMSGLDEEGNSVRTFQVCPMDSSVSHWLRTRFIPRHGASQVYVEIRFTMMECSAMPASFRTCKETFNLYYYQSDEDTASATHPAWMENPYSKVDTVAADFLLRRGGERKSNVKTVRVGPLSKKGFYLAFQTQGACMALLSVRVFFKKCPAVSRAFSSFPETLPHSLVQQAEGVCVDNSAPTGQSTAPPTMFCGEDGQWVGPPSSTCACKPGYEPVDSDRCRACGLGQYKASVGGSLCRVCPDNSNTHFAGSSLCVCRPGYHRATSDLPDSACTKPPSAPRSIIYQINDTVVTLEWSEPLDRGGRSDLSYSVECMHCRGSLCVQCADSITYRPGQMGVPGRRVIIRGLLPHTTYTFTVLAQNGVSAVSHTSPASSSVNITTSRDVAVPVSGIRRIKASESSVSISWTVPPQTQHSIQDYQLRYSLKGQDDGWQYVSSRSSSVVLNDLSRASQYQVQVRARTAAGYGHFSSAVSISTLPDDEESPSRLMLTGVLVAIGLLILIAVVIVAVFCFRRSTRRRDPDPDKSGQFLMGQGIKVYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVCRGRLKVPGKKENYVAIKTLKGGYTDKQRRDFLSEASIMGQFQHPNIIHLEGVITASCPVMILTEYMENGALDSFLRLNDGQFTPIQLVGMLRGIASGMKYLSEMSFVHRDLAARNILVNSNLVCKVSDFGLSRFLTENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPECPASLHQLMLDCWQKERSSRPRFCAIVSALDRLIRNPASLKITGRIPDGPSHPLLDQRAPPPLSHCSSVADWLRAIKMERYEDAFMQAGFTAIQHITHISTEDLLRIGVTLAGHQKKILSSVQTLRIHGGSLRY
Protein: LD23870p (RNA-binding protein S1) (Q9VHC0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone deacetylase complex subunit SAP18
- RE04053p
- Acinus, isoform A
- Eukaryotic initiation factor 4A-III
- Pinin, isoform B
- RNA-binding protein 8A
- Dorsal interacting protein 4
- IP10578p
- FI21285p1
- Regulator of nonsense transcripts 1 homolog
Sequence:
MARAQSLAGEGEKEKDNKEKVAKEKDGKATSGSSRRDRERKRRGSASSSSDSRSSTSDSSSSRSSSGSSRSSSSSSSDSSSSSSSSSSDSDRSEKNRRRGGGAAGKDKDKDKPSARSRSRSRTRSPRRVSKSPRPGSKARKEPERDRDRRSRSRDRARRAGSNDRAAADSNNVKRERSRSASRSRSPRRRGRGSVERTPPPKRRERSRSRTRSPSPKQVRIHVGRLTRNVTKDHVFEIFSSFGDVKNVEFPVDRFHPNFGRGVAFVEYATPEDCESAMKHMDGGQIDGQEITVSPVVLVKQRPPMRRPSPPMRRPQNNRWRSPPQFNRFNNRGGGGGGGGGRRQSPMRNRRSPRRRSRSPIRRRRRSNSSDSSR
Protein: Immunoglobulin lambda variable 2-11 (Ig gamma lambda chain V-II region DOT) (Ig lambda chain V-II region BOH) (Ig lambda chain V-II region BUR) (Ig lambda chain V-II region NIG-58) (Ig lambda chain V-II region TRO) (Ig lambda chain V-II region WIN) (P01706)
Organism: Homo sapiens (Human)
Function: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular location: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
Interaction partners:
Sequence:
MAWALLLLSLLTQGTGSWAQSALTQPRSVSGSPGQSVTISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSKRPSGVPDRFSGSKSGNTASLTISGLQAEDEADYYCCSYAGSYTFH
Protein: POU domain, class 2, transcription factor 3 (Octamer-binding protein 11) (Oct-11) (Octamer-binding transcription factor 11) (OTF-11) (Transcription factor Skn-1) (P42571)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation. The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P31362}.
Interaction partners:
- POU domain protein
- POU domain, class 2, transcription factor 1
- Transient receptor potential cation channel, subfamily M, member 5
- DDB1- and CUL4-associated factor 11
Sequence:
MVNLEPMHTEIKMSGDVADSTDARSTFGQVESGNDRNGLDFNRQIKTEDLGDTLQQSLSHRPCHLSQGPTMMPGNQMSGDMASLHPLQQLVLVPGHLQSVSQFLLSQTPPGQQGLQPNLLSFPQQQSTLLLPQTGPGLTSQAVGRPGLSGSSLEPHLEASQHLPGPKHLPGPGGNDEPTDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSASTPSSYPTLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPVKPPIYNSRLVSPSGSLGSLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQNNSKAAMNPSSAAFNSSGSWYRWNHPAYLH
Protein: LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein (A0A1D8PCT5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MADFRQFRNIFLVVLFFNLCYFLKIYRNNKIQNEILNFRHSYYNYYNDDQISIGYLKEEDSLPEEQELLQLLHKVKRNENNTYWLANTTMEYPSIMLNALDFLPPPENEPQYITWYNNPKLYYEPRLTLAVYLDELKHQLKLHNPDNSKTKDHMIKLPFSWSDWVDLTMLNSEIMKPIGLKNNCEWLQKEANKRTRFPDFCKDLVDLSDEEIDEIGLSKDQLPGFIVKSSPMNKAPHMEVMLQGKSYLYTQQENPLTLVFLTSNGTYEAQLTEKREKLLQTDLFHRFLKRRKIDCKQAHGVVPVEFNPQSEFRKLLRAIPPRPLDPKDDLHGISKIVSNKGDRNILRQLNLDPSTFHYTQQNVEQQIASYETRLSKIEKVITDELNYDLNVLETNRLTRHELNHYRGLKYANSFSVDVEPTYYKLATLKKNQYNLDSGWHYEWRFFNGAMRYLKDETWSYEQMEVREQIILDRLLRNWFKFAEAKGIVSWIAHGPLLSWYWDGLMFPFDIDIDLQMPSSELNRLAANYNMTLVIEDLNEGYGKYLIDCSTFIHHRNVAGRDNHIDARFIDVDTGTYIDITGMGLNDEKPPPQYDNYINEKTEANESVELYMDRRKHWLNYEKINPLRYSMLGGVPVFVPNDIMSMLNHEYPRGTKSHYYDGYYYVPLLRLWLQESKILTAFKPEQYEAVTDEARQENILELIKNLRHEDAFQLLTSSNDILIEYYLTQKYTGLHVREKQLMMDEASERSILDLEHNEQYNSLTSNFYIGPPLRKCLFDFEYYGRFKHMAKQTVSTIVENEKMEESKTF