wanglab/gogpt-training-data huggingface dataset:
Protein: Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine-protein kinase NKIAMRE) (Q8IVW4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRVIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKENPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQEDPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGMEVKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW
Protein: Probable flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Gp48) (O64238)
Organism: Mycobacterium phage D29 (Mycobacteriophage D29)
Function: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Interaction partners:
Sequence:
MKVQLIASTILEDPSWAGTDYVGDDETVTSADELAEFAGRNCYLSFDRPNPKTRENVDYLNHILDVGHESVLEHSSATFYIEASRSVLTELERHRHLSFSVVSQRYVDPTELGIHVPPAFTELSGSDADKAKEVLLDVQSFAQEAYEYLVHIFSDAGFPRKKAREAARAVLPNMTNSPMVVTGNHRAWRYVIKNRWHEAADAEIRELAGELLRQLREIAPNTYQDIPTEPYSYGG
Protein: C-type LECtin (Q9NAK5)
Organism: Caenorhabditis elegans
Interaction partners:
- C-type lectin domain-containing protein
- C-type lectin domain-containing protein
- VWFA domain-containing protein
- Lysozyme-like protein 2
- CUB_2 domain-containing protein
- CUB-like domain-containing protein
- CUB-like domain-containing protein
- Sulfhydryl oxidase
Sequence:
MQFYSVLLLVSLLLLLTISEASYPPVCTSGFTLINGKCLRIFVDVSTHTAAEKTCKGYGATLVTVKNSIDNRAIADFTGNNANLFWMGLYCFDSDVSKCLWDDATGSAEVYDNFAAGFPHIALGNCVYYSVQGALAGMWLSSDCNDRRSFICELPASHADPCPYNYNGFCYTFHNTASTYTKGQKICEQECGNLASIHSANENRYIMTFGGRATKEDLLLGGMWPADDVYNWVDGSLWEYENFDPINVRDSVCVIMSNGDSRPIALGMWYSGECKNEYSVVCKRPAGIQCPPNPTIVPVTPMPAVQSFCNSSVMAPSEITSPHFPYNYYNSDFCSYQISTLGSYNVLLRFSTFDTEKVNDVVTVYDGDSTNDPVIGVYAGSFYPFTVISTGNKMLVTFKTDKSNTRQGFSGRITSYSTTESGERD
Protein: Ataxin 2 (A0A2R8Y5A6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVKYLELELLRYVPNMPQQRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL
Protein: Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein) (P60953)
Organism: Homo sapiens (Human)
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22843693}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15642749}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15642749}. Midbody {ECO:0000269|PubMed:15642749}. Cell projection, dendrite {ECO:0000250|UniProtKB:P60766}. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase (PubMed:15642749). Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells (PubMed:15642749). Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1 (PubMed:15642749). Colocalizes with NEK6 in the centrosome (PubMed:20873783). In its active GTP-bound form localizes to the leading edge membrane of migrating dendritic cells (By similarity). {ECO:0000250|UniProtKB:P60766, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:20873783}.
Interaction partners:
- Rho guanine nucleotide exchange factor 7
- Rho GTPase-activating protein 1
- Intersectin-1
- Activated CDC42 kinase 1
- Ras GTPase-activating-like protein IQGAP2
- Actin nucleation-promoting factor WASL
- Partitioning defective 6 homolog beta
- Ras GTPase-activating-like protein IQGAP1
- Serine/threonine-protein kinase PAK 1
- Serine/threonine-protein kinase PAK 6
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
Protein: Uncharacterized protein YHR212W-A (P0CX91)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MPYHYLFLALFTYLATSNVVSGSTQACLPVGPRKNGMNVNFYKYSLLDSTTYSYPQYMTSGYASNWN
Protein: Fanconi anemia group I protein homolog (Q54BR4)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Fanconi anemia group D2 protein homolog
- RING-type domain-containing protein
- WD repeat-containing protein 48 homolog
- DNA helicase
- Uncharacterized protein
- Fanconi-associated nuclease 1 homolog
- PARP catalytic domain-containing protein
- Ubiquitin domain-containing protein
- Ubiquitin domain-containing protein
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MGKSKKTIDSKDKSKKHKRVNEHSENELDEEEIKHSDEEVQEEEVEEVEEVEEVEEDEEERRERKERKRKEKKERKEKRKLKKKEKKNRDNNEDEDEDVDSNENDGIDIDDGDENSDHIDNVNNNNNNSSSDKDEENIKNQNEKNKKKKDSQQQKQQQQPKIIAYNNPYRNKNYNGKRFDEFIIEESKKRIPINNNSNNNNNNENETNEDIDENNDDLMFSSQNQKKKQKNNNNNNNNNMTSSKLDIDNLYLIFLSMQDDTDEIAKFLTKRIHERKEIFEYIQVVMKSIMSEKDLKEQKELRGKMFEKFLNEFITYDNIVSIDEKQLEQCIDFLLTECDGLSRHTYREIANLIADSISTIRKPPILQLIPRVFEQLSYQSDCKSVVDQEADESFKSSIVDTICKQRWDPLVFSLIVSMFNDMTLTKAHLELVVAKIFKDGRELHLDEYPALMNNVMLLSRQGLKGKILFSICEFFGELDLRYPPDHHGTQDNGLSYIESFVLTQLTLSIRSDPEIAREYLKLNQNPSHFVIGLLMSMSKIPRHKLIAIDCLKSLSNQVVRKGTDNIEQLFLGAVSKNWENVLDPFVNFAISLMDSNGLVITEQIKSLRIVGGKILFELYVRHNSIRDKIIDEIVGRIVMKSNQISQNWFNLLGRIAEEQQFTIRKYLSKLKELFDYLQYYNASTVKQLIGALKPLLLSDGASFLNNVIIVLKKSMFAREVEARASAVTGFIELLKCVSEILLSINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNRNNNEHLEKLRNFKIEVFSNLRRALTQQCEIRSILYQGFIDLIGFEKGNGMEFADDIFELLNIQSLHYLELSGNNNSPINIDECLELKQNQVCLVEPIDRLIYCIQYCLNHVFTREHEKLYDQFSKEEAKQNPQPSTQQQKQSLFSNSQSRKPTLLTAQQRINVNRKVLDSLKNIKKSSSRIDLEKTFLKFEALMNECRLDSFELRKFGVSNTKAVAASQLLIGVLEALIENSSLQFQPSFGRILALFSLYSDIKNFQSENQAAIKSSSNSNTSKSKKSKKGSKNNDNNGDDDEDDDINDDNTGSDENGENDENDSDNNKKSKSKKTSSSSSKTSSSSSSSSSSSNNVTSNEFPSQKCTQTILKIIYNSNEFNRNNIQHKNFLTYIYTTLSNLLTKLSNSTKSLKKTTDLDSHNKSLRITMEFFKEILPFVYQEFSYQEWITPPKLEKKTDTKKVLVHSLALSCFLTIVQFVNENGNEANLHIVFNNTIDEIKKKEFEKAVLSYKRDHEYYEQQQLQRIAKRSGKSKQQQQNNNRGGNSDDDGDQIMENVEEEEEEELIEPVEPNRESFKPERGPKVIQSISVCIETIIVQHLFPEYYTDLECLFNILTILYSHIQDVQTCFLFLKKISSKHAIESPTLANIILKSIIDMCNSKNSPITETLAKYVLASQGTYKNQSQPVDAYNKPIPPKVLAIINSKTVATAINLLLSNEESVIDRSRERISQFKKDWNSIGKSMSSSNSSNDKIAIDAFNDRNKLASTLNSTCQVLNQLAITKIAGSPHEKFLKLIKKLYTVLTTFINFLIQITTGAITPEIEDLINQSSLLYSYVVDFIEWTNNSLEKDTNNNNNTKKLSKLDLQRMGRESKLLPTITFTLTKYETTVIKYQKKLGGRFILGKHFKEIKFREFFIDTDKLAGIITNDDDGNPVKPPPKKKISKQAPKKSSAGTKRKVRSNDENDDTDGVGDNNDDDDDDDTSPKKKRSVNVSKPKKLYPKYKKK
Protein: Splicing factor 3b subunit 1, isoform A (Splicing factor 3b subunit 1, isoform B) (Q9VPR5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Probable ATP-dependent RNA helicase DDX46
- Splicing factor 3B subunit 5
- LD21442p
- LD45152p
- Splicing factor 3B subunit 4
- Splicing factor 3A subunit 1
- PHD finger-like domain-containing protein 5A
- Splicing factor 3B subunit 6
- Splicing factor 3B subunit 3
- Splicing factor 3A subunit 2
Sequence:
MENIPRTHEDIEAQISVIQEKKTELAKTTAAAAGVGLLDSGGFFDSDLYDDDAAKGKGRYEGYNTSIAANDAEEVDEDEDDGFPVPQKRTTYTAPASVLKDVTQGKEDVDPMADRRRPTIADREDEYRQKRRHIIISPERADPFADGGKTPDVGSRTYTDIMREQMLKGEESELRRRILEKTKEGTLVKTVTSSSTSNGDLPAPKDGGRKRGRWDQTVSDSFIPAKMATPSSAATPTWEDKTPGDHRWDETPGHKGSETPGATPGLGTRIWDATPAHAVTPGHETPGHEKSARRNRWDETPKTERETPGHSGWAETPKPDRTGSGGGAESISIESTPGASKRRSRWDETPSNATPAITPTNASAMTPNMTPSMTPHVTPGHATPMLTPGGSTPIGVKAMAMATPSAGALAAMTPEQLQAYRWEKEIDERNRPYTDEELDQIFPPGYKILPPPAGYVPLRTPGRKLMATPTPIAGTPAGFFIQVEDKNAKFMDNQPKGQNLPFMKPEDAQYFDKLLVDVNEDSLSPEELKERKIMKLLLTIKNGSPPMRKSALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDHYARIEGREIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLKALVEIIEHGLVDEQQKVRTITALAIAALAEAATPYGIESFDSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCATDGVEPQYIKEEILPHFFKFFWNHRMALDRRNYRQLVDTTVEIANKVGASEIINRVVDDLKDENEQYRKMVMETVEKIMGNLGAADIDSRLEEQLIDGILYAFQEQTTEDVVMLNGFGTIVNQLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGPEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAESCRPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVCPLLEDALMDRDLVHRQTACSAIKHMSLGVYGFGCEDALTHLLNYVWPNIFETSPHLVQAFMDSVDGLRVSLGPIKILQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDALIAGYPRITNDPKNQYERYELDYTL
Protein: Ankyrin repeat 30A-like protein (DUF662) (At3g09980) (Q8RXZ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Carboxylesterase SOBER1
- Protein OXIDATIVE STRESS 3 LIKE 4
- LIMR family protein At5g01460
- CASP-like protein 5A2
- Ternary complex factor MIP1 leucine-zipper protein
- Probable carboxylesterase SOBER1-like
- Putative RRM-containing protein family protein)
- Nuclear polyadenylated RNA-binding protein
- Protein OXIDATIVE STRESS 3 LIKE 3
- Protein RALF-like 31
Sequence:
MKEMQAIETSQPTTVAPAVHSRQLGAQLSGSMSFSSQMSKEDEEMSRTALSAFRAKEEEIEKKKMEIRERVQAQLGRVEEETKRLALIREELEGLADPMRKEVAMVRKKIDSVNKELKPLGHTVQKKEREYKEALEAFNEKNREKVQLITRLMELVGESEKMRMKKLEELSKNIDSIH
Protein: Cell differentiation protein rcd1 (Q92368)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: A differentiation-controlling factor that is essential for the onset of sexual development. Induces ste11 when sexual development is invoked through nitrogen starvation.
Interaction partners:
- Poly
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- General negative regulator of transcription subunit 3
- General negative regulator of transcription subunit 1
- General negative regulator of transcription subunit 2
- Putative general negative regulator of transcription C16C9.04c
- ABC transporter domain-containing protein C20G4.01
- RNA binding exosome specificity factor Mmi1
- Uncharacterized RNA-binding protein C644.16
- Cleavage and termination factor 1
Sequence:
MENLESPNYEPALVYEWIIQLVSGTSREQALVELSRKREQYEDLALILWHSYGVMTALLQEIISVYPLLNPPTLTGPTSNRVCNALALLQCIASHPETRIHFLNAHITLFLYPFLNTLSKSKPFEYLRLTSLGVIGALVKNDSPEVINFLLSTEIIPLCLRIMENGSELSKTVAIFIVQKFLCDDVGLQYICQTYERFYAVASVLNNMVMQLVDSFAFRLLKHVIRCYLRLSDNPRAREALRHCLPEPLRDATFAQVLKDDHNTKKCLAQLLINLSDVAVVNQ
Protein: Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) (Q9UKT9)
Organism: Homo sapiens (Human)
Function: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Subcellular location: Nucleus {ECO:0000269|PubMed:10369681}. Cytoplasm {ECO:0000269|PubMed:10369681}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:17646674, ECO:0000269|PubMed:34155405}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:17646674}.; SUBCELLULAR LOCATION: [Isoform 11]: Nucleus {ECO:0000269|PubMed:17646674}.; SUBCELLULAR LOCATION: [Isoform 14]: Nucleus {ECO:0000269|PubMed:17646674}. Cytoplasm {ECO:0000269|PubMed:17646674}.; SUBCELLULAR LOCATION: [Isoform 12]: Cytoplasm {ECO:0000269|PubMed:17646674}.
Interaction partners:
- Protein cereblon
- Zona pellucida-binding protein 2
- DNA-binding protein Ikaros
- Paired box protein Pax-5
- Transcription factor COE1
- Gasdermin-B
- Zinc finger protein Eos
- Runt-related transcription factor 3
- Runt-related transcription factor 1
- Zinc finger protein Pegasus
Sequence:
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK
Protein: Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) (Q8TF42)
Organism: Homo sapiens (Human)
Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}.
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- Epidermal growth factor receptor
- SHC-transforming protein 1
- Probable phosphoglycerate mutase 4
- Phosphoglycerate mutase 1
- Tyrosine-protein kinase ZAP-70
- Growth factor receptor-bound protein 2
- Lymphocyte cytosolic protein 2
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- Polyubiquitin-C
Sequence:
MAQYGHPSPLGMAAREELYSKVTPRRNRQQRPGTIKHGSALDVLLSMGFPRARAQKALASTGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQICGKNKAHNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSNFIGLFVKEDSAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASHLPTLEKLAQNIDVKLGCDWVATIFSRDIRFANHETLQVIYPYTPQNDDELELVPGDFIFMSPMEQTSTSEGWIYGTSLTTGCSGLLPENYITKADECSTWIFHGSYSILNTSSSNSLTFGDGVLERRPYEDQGLGETTPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYWLSQCFDAKGRYIRTNLNMPHSLPQRSGGFRDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGLQQENHLKIRVEPGLFEWTKWVAGSTLPAWIPPSELAAANLSVDTTYRPHIPISKLVVSESYDTYISRSFQVTKEIISECKSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFVQMVRKIPYLGFCSCEELGETGIWQLTDPPILPLTHGPTGGFNWRETLLQE
Protein: 26S proteasome regulatory subunit RPN1 (HMG-CoA reductase degradation protein 2) (Proteasome non-ATPase subunit 1) (P38764)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- Proteasome subunit alpha type-6
- 26S proteasome regulatory subunit 6A
- Proteasome subunit beta type-7
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit RPN2
- Probable proteasome subunit alpha type-7
- Proteasome subunit beta type-3
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-5
- 26S proteasome regulatory subunit 6B homolog
Sequence:
MVDESDKKQQTIDEQSQISPEKQTPNKKDKKKEEEEQLSEEDAKLKTDLELLVERLKEDDSSLYEASLNALKESIKNSTSSMTAVPKPLKFLRPTYPDLCSIYDKWTDPNLKSSLADVLSILAMTYSENGKHDSLRYRLLSDVSDFEGWGHEYIRHLALEIGEVYNDQVEKDAEDETSSDGSKSDGSAATSGFEFSKEDTLRLCLDIVPYFLKHNGEEDAVDLLLEIESIDKLPQFVDENTFQRVCQYMVACVPLLPPPEDVAFLKTAYSIYLSQNELTDAIALAVRLGEEDMIRSVFDATSDPVMHKQLAYILAAQKTSFEYEGVQDIIGNGKLSEHFLYLAKELNLTGPKVPEDIYKSHLDNSKSVFSSAGLDSAQQNLASSFVNGFLNLGYCNDKLIVDNDNWVYKTKGDGMTSAVASIGSIYQWNLDGLQQLDKYLYVDEPEVKAGALLGIGISASGVHDGEVEPALLLLQDYVTNPDTKISSAAILGLGIAFAGSKNDEVLGLLLPIAASTDLPIETAAMASLALAHVFVGTCNGDITTSIMDNFLERTAIELKTDWVRFLALALGILYMGQGEQVDDVLETISAIEHPMTSAIEVLVGSCAYTGTGDVLLIQDLLHRLTPKNVKGEEDADEEETAEGQTNSISDFLGEQVNEPTKNEEAEIEVDEMEVDAEGEEVEVKAEITEKKNGESLEGEEIKSEEKKGKSSDKDATTDGKNDDEEEEKEAGIVDELAYAVLGIALIALGEDIGKEMSLRHFGHLMHYGNEHIRRMVPLAMGIVSVSDPQMKVFDTLTRFSHDADLEVSMNSIFAMGLCGAGTNNARLAQLLRQLASYYSREQDALFITRLAQGLLHLGKGTMTMDVFNDAHVLNKVTLASILTTAVGLVSPSFMLKHHQLFYMLNAGIRPKFILALNDEGEPIKVNVRVGQAVETVGQAGRPKKITGWITQSTPVLLNHGERAELETDEYISYTSHIEGVVILKKNPDYREEE
Protein: Zinc finger protein 819 (E9Q5X9)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKKVKDSPMGKVDFPHQRCGQGEAEHDSHQMCVKAAFPNDVSRVITTGGSYCSIIEEPWQGGDPKTSDPQNHIPPSSSGAFFSQKTLITDGREAAGGSIPLGAHVISTQKRSLRCCPCEKTLQPHLQADRDHQSSATEQPDGIVDSCQSFTQGLPTAVCPIHSTGEEARRGDQCASVPSPQQPFMQHGTLSQDKPVEYTKYEKVFTAGSALCQQQTTNPLETHFICHICGKSFLQKSELSFHPGTDRGETHHGCPGCRKSLPSTSSLQARHGTHTKEKPYRCPDCGKSFSYASHLKIHLRIHTGERPYVCSDCGKAFSQKSVLTTHRRIHTGERPYTCNHCGKLFVYASDLKKHSRFHTGEKPYECRDCGKLFNNKSHLPVHYRIHTGEKPYRCCDCGKSFRRKSHLKVHSRTHTGEKPYECPDCGRAFSHSSVLSTHQRIHTGERPYLCSDCGKAMSSKAQLNEHRRIHTGEKPYVCSECGKAFSCRSSLQAHRRTHSREKPFVCHTCGKGFLHKSQLSSHQQTHTGENP
Protein: Rap guanine nucleotide exchange factor (GEF) 1 (A0A5F8MPI9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGNAVEKQKPLRQSHLCPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKIPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTDREMEILNKTTSVSPSAELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPPQAACNLSPLPESLGESGPPFLGHPFQLPLGSCLQQEGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
Protein: SPI-2 type 3 secretion system translocon protein SctB (SPI-2 T3SS translocon protein SctB) (Secreted effector protein SseD) (Secretion system effector D) (Q9R803)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. May act as a translocator that mediates translocation of SPI-2 TTSS effector proteins from intraphagosomal bacterial cells into the host cells.
Subcellular location: Secreted {ECO:0000269|PubMed:11159962, ECO:0000269|PubMed:11567004}. Cell surface {ECO:0000269|PubMed:11159962, ECO:0000269|PubMed:11567004}. Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Note=Secreted via the type III secretion system 2 (SPI-2 T3SS) (PubMed:11159962, PubMed:11567004). After secretion, localizes mainly on the surface of the bacterial cell (PubMed:11159962, PubMed:11567004). {ECO:0000269|PubMed:11159962, ECO:0000269|PubMed:11567004}.
Interaction partners:
- SPI-2 type 3 secretion system translocon protein SctE
- Secretion system effector
- Secretion system chaparone
- Type III secretion system chaperone SseA
- Secreted effector protein SseB
- Secretion system apparatus protein SsaL
- Secretion system apparatus lipoprotein SsaJ
- Secretion system apparatus protein
- Secretion system chaparone
- Secretion system effector
Sequence:
MEASNVALVLPAPSLLTPSSTPSPSGEGMGTESMLLLFDDIWMKLMELAKKLRDIMRSYNVEKQRLAWELQVNVLQTQMKTIDEAFRASMITAGGAMLSGVLTIGLGAVGGETGLIAGQAVGHTAGGVMGLGAGVAQRQSDQDKAIADLQQNGAQSYNKSLTEIMEKATEIMQQIIGVGSSLVTVLAEILRALTR
Protein: Vinculin (Metavinculin) (C7EYJ3)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}. Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004278}. Cell projection, podosome {ECO:0000256|ARBA:ARBA00004188}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVSAVQAAVSNLVRVGKETVQTTEDQILKRAMPPAFIKVENACTKLVRAAQMLQADPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGLLEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNTKSQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALALIDSKMNQAKGWLRDPNAPPGDAGEQAIRQILDEAGKAGELCAGKERREILGTCKTLGQMTDQLADLRARGQGATPMAMQKAQQVSQGLDLLTAKVENAARKLEAMTNSKQAIAKKIDAAQNWLADPNGGSEGEEHIRGIMSEARKVAELCEEPKERDDILRSLGEIPALTAKLSDLRRHGKGDSPEARALAKQIATSLQNLQSKTNRAVANTRPVKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGRRLANVMMGPYRQDLLAKCDRVDQLAAQLADLAARGEGESPQARAIAAQLQDSLKDLKARMQEAMTQEVSDIFSDTTTPIKLLAVAATAPSDTPNREEVFEERAANFENHAARLGATAEKAAAVGTANKTTVEGIQATVKSARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANMQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEHLHLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEAINQPMMMAARQLHDEARKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGNKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ
Protein: tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Q9U6H7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPLIVSSSIMIHAKLIYTFEDAQLDGQIVAALDVNTVANAVYAHNYGSNLVKTRNIQSLSVKEVTKLQANMLLMSPPCQPHTRQGLQRDTEDKRSDALTHLCGLIPECQELEYILMENVKGFESSQARNQFIESLERPGFHWREFILTPTQFNVPNTRYRYYCIARKGSDFPFAGGKIWEEMPGAIAQNQALSQIAEIVEENVSPDFLVPDDVLTKRVLVMDIIHPAQSRSMCFTKGYTHYTEGTGSAYTPLSEDESHRIFELVKEIDTSNQDASKSEKIVQQRLDLLHQVRLRYFTPREVARLMSFPENFEFPPETTNRQKYRLLGNSINVKVVGELIKLLTIK