wanglab/gogpt-training-data huggingface dataset:
Protein: Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1-M) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (CPT I) (CPTI-M) (Carnitine palmitoyltransferase 1B) (Q924X2)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q92523}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acetyl-CoA carboxylase 2
- Carnitine O-palmitoyltransferase 2, mitochondrial
- Carnitine O-palmitoyltransferase 1, liver isoform
- Palmitoyl thioesterase CPT1C
- Long-chain-fatty-acid--CoA ligase 1
- Fatty acid CoA ligase Acsl3
- Long-chain-fatty-acid--CoA ligase 5
- Mitochondrial carnitine/acylcarnitine carrier protein
- Long-chain-fatty-acid--CoA ligase 4
- Lipid transferase CIDEA
Sequence:
MAEAHQAVAFQFTVTPDGVDFRLSREALRHIYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATVGSNYCKVDISMGLVDCIQRCLPERYGHFGTPQTEALLSMVIFSTGVWATGIFFFRQTLKLLLSYHGWMFEMHSKTSHATKIWAICVRLLSSRRPMLYSFQTSLPKLPVPSVPATIHRYLDSVRPLLDDEAYYRMETLAKEFQDKTAPRLQKYLVLKSWWATNYVSDWWEEYVYLRSRSPLMVNSNYYAMDFVLIKNTNVQAARLGNAVHAMIMYRRKLDREEIKPVMALGMVPMCSYQMERMFNTTRIPGKETDLLQHLSESRHVAVYHKGRFFKVWLYEGSRLLKPRDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAEARQTFFSSGKNKMSLDAIERAAFFVTLDEDSHCYNPDDETSLSLYGKALLHGNCYNRWFDKSFTLISCKNGLLGLNTEHSWADAPIIGHLWEFVLGTDTFHLGYTETGHCVGEPNTTLPPPQRLPWDIPEQCREAIENSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDKGKFCLTYEASMTRMFREGRTETVRSCTNESAAFVQAMMKGSHKKQDLQDLFRKASEKHQNMYRLAMTGAGIDRHLFCLYIVSKYLGVSSPFLAEVLSEPWSLSTSQIPQFQICMFDPKQYPNHLGAGGGFGPVADDGYGVSYMIAGENTMFFHISSKYSSSETNAQRFGNHIRQALLDIAELFKISKTDS
Protein: OsmC-like protein (Q583X0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRSSMKFGLRQILSEELGKAAIFLRFKANEYIASTARACQTLTGAETNPEQANKRRKHRQVYEEILRQRQQVAQEAARRAMEGKSLRERLMASASAALKGLKEATSTNAGALALLQHCTAAHAAEVAVEQGIDVKSVTMQVEERKTGSQVGSETVVVGYIDAPNTSEEEMMAFAEQLSKKCPMANAMRGKIEWRRANGEVQHNDEQTTGNDNSVGSTSDKAGDAGSIPHGMPGTRYYSHESMRRGAGGVGDGDELHLPGVTKGSGKGPDK
Protein: Basic helix-loop-helix (BHLH) DNA-binding superfamily protein (F4K9L3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MELPQPRPFKTQEFRTGRKPTHDFLSLCSHSTVHPDPKPTPPPSSQGSHLKTHDFLQPLECVGAKEDVSRINSTTTASEKPPPPAPPPPLQHVLPGGIGTYTISPIPYFHHHHQRIPKPELSPPMMFNANERNVLDENSNSNCSSYAAASSGFTLWDESASGKKGQTRKENSVGERVNMRADVAATVGQWPVAERRSQSLTNNHMSGFSSLSSSQGSVLKSQSFMDMIRSAKGSSQEDDLDDEEDFIMKKESSSTSQSHRVDLRVKADVRGSPNDQKLNTPRSKHSATEQRRRSKINDRFQMLRQLIPNSDQKRDKASFLLEVIEYIQFLQEKADKYVTSYQGWNHEPAKLLNWSNNNQQLVPEGVAFAPKLEEEKNNIPVSVLATAQGVVIDHPTTATTSPFPLSIQSNSFFSPVIAGNPVPQFHARVASSEAVEPSPSSRSQKEEEDEEVLEGNIRISSVYSQGLVKTLREALENSGVDLTKASISVEIELAKQSSSSSFKDHEVREPVSRTRNDNVKQTRKPKRLKTGQ
Protein: DNA-binding response regulator, LuxR family, near polyamine transporter (E0SE56)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Interaction partners:
- Type III protein secretion system sensor kinase
- histidine kinase
- RNA polymerase sigma-54 factor rpoN
- Sensor protein
- Sensor protein uhpB
Sequence:
MDRLIKLMIADDHVIMREGLKQIFALDDNLEVVAEAGTGSQVLAQLRESQVDLLLLDMSMPGICGEELIIRIVAQYPRLPILVLSMYSEPQIARRVLKSGALGYITKDKDPEALLSAIRRVAQGARYIDHSIAEQIVFADCQTRGDGRNELLTSREHQIMVMLAQGLGVNAIAEMLAISNKTVSTHKSRLMEKMQFTTNADIVKYALSQRLIA
Protein: Proliferating cell nuclear antigen (PCNA) (Q9PTP1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P12004}.
Interaction partners:
- Replication factor C
- Replication factor C
- Polymerase
- DNA polymerase.
- Replication factor C
- DNA mismatch repair protein
- Activator 1 subunit 5
- DNA polymerase eta
- DNA ligase
- Replication factor C subunit 1
Sequence:
MFEARLVQGSILKKVLEALKDLITEACWDVSSSGISLQSMDSSHVSLVQLTLRSDGFDSYRCDRNLAMGVNLSSMSKILKCAGNEDIITLRAEDNADALALVFETLNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSQIGDAVMISCAKDGVKFSASGELGTGNIKLSQTSNVDKEDEAVTIEMNEPVQLIFALNYLNFFTKATPLSKTVTLSMSADIPLVVEYKIADMGHVKYYLAPKIDEESS
Protein: Actin-related protein 2/3 complex subunit 2-B (Q6IRB1)
Organism: Xenopus laevis (African clawed frog)
Function: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q0IH88}. Cell projection {ECO:0000250|UniProtKB:Q0IH88}. Nucleus {ECO:0000269|PubMed:29925947}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 3-A
- Actin-related protein 2/3 complex subunit 3-A
- Actin-related protein 3-B
- Actin-related protein 2/3 complex subunit 3-B
- Actin-related protein 2/3 complex subunit 5-B
- Actin-related protein 2/3 complex subunit 1A-A
- Actin-related protein 2
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 5-A
Sequence:
MILLEVNNRIIEEILTLKFENAAAGNKPEVVEVTFADFDGVLYHVSNPNGDKAKVMISISLKFYKELQEHGADEVLKNVYGNFLVAPESGYNVSLLYDLEALPSNKDSVIHQAGMLKRNCFASVFEKYFKFQEEGKEGEKRAVIHYREDETMYVEAKKDRVTVVFSTVFKDDDDVVIGKVFMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTSANARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFAAR
Protein: Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC 1.1.1.8) (Q7JMU1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLSRLSSIFRYFGTTSTIATMSPKKVTIIGSGNWGSAIARIVGSTTKSFPDEFDPTVRMWVFEEIVNGEKLSEVINNRHENIKYLPGKVLPNNVVAVTDLVESCEGSNVLVFVVPHQFVKGICEKLVGKIPADTQAISLIKGVSTEKRGGLKLISEEIKEILKIEVSVLMGANLAPEVANDNFCEATIGCKRKAEDGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVEHYYPGSNLQTFFESCGIADLITTCYGGRNRKVCEAFVKTGKSMAEVEKELLNGQSAQGPLTAEEVYLMMHKTGLDAKFPLFTAVHKICAGEMKPAELVDCLRNHPEHM
Protein: Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Q4V9P5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MIPIAVVVCVMGGWCTVYLADTLLRSSSSVKNRYESWLSSNGFTLSPFHIKWHTGIFNRLFARCAHFNPHFLYIWFSAGMVFGVLAMFGSVVLLSKTLLQTLHQMMADTPDGSHEQVLQVVVPGVNLPVSQLAYFFIAILVSGVIHEFGHGVAALREQVRLNGFGMFMFVIYPGAFVDLFTTHLNLISPVQQLRIFCAGVWHNFMLCVVALSFLFLLPIFLFPFYYTGAGALVTEVAEGSPSSGPRGLFLGDLITQLEDCTVRGVQDWHSCVQHLSHNPQTGYCVHTAKLHLSYTQGRAFKRLDGTMECCGNNSLTDLCFSYSNNVESKLFACLPVRKTIEASRTCHTNTDCQTDFTPSLCLIPSLENQTRLIRVKHPPQTDMLFVGYSSHLQYSVSLTNFVPRLGFLHPDLPVMLETFCKYLVSLSGALAVVNAVPCFALDGQWMLTAFLEATLSSVIQERNNRELIGFFFLLGGSALLAANVALGLWMVTAR
Protein: Pep7p (Q59UQ8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Vacuolar protein sorting-associated protein 45
- Rab family GTPase
- Rab family GTPase
- Rab family GTPase
- Rab family GTPase
- N-acetyltransferase domain-containing protein
- Uncharacterized protein
- N-acetyltransferase domain-containing protein
Sequence:
MQTSSTPPRKINRISFSDQGFSIGDSEYNAPGSPIKRSHWKQSSSVNRCTLCDTTLSVKNGIVNCRKCGELFCNEHTHYKVRLRNPDKGETTPQYDSRGVWCRCCETCFFNKQKSTEVNSVDLTEQFKQKRLAKVEAQQLHRTRIQRNFIKLTDSLMNKSSVDGIANWSPNTKNCSICFVEFNLFIRRHHCRLCGSVVCDDPNGTRKGCSMNVPLVKLVEKLPQLNYTHEYEEIDENLRFRCCIDCKNSLLFDWKRNLDSDNKVLTMYEAMLLQRQQIEKLMPQYEQLVGDNDDSSKLRNKLVHVLKELEILVFQFRDEFFTRDNERIVIRIGYEQYEKVITNIYQGVAVFLQDNLLKYKQITEKYKQKTEIPRTPSPPRLTKKEIREMREQLMVMNEQKFLVENLIKEYTKARRFDELDSLIANKNELNETIARLESELGEFGF
Protein: Cyclin B1 (D6RHI0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGL
Protein: Bactericidal permeability-increasing protein (BPI) (Q67E05)
Organism: Mus musculus (Mouse)
Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P17213}. Cytoplasmic granule membrane {ECO:0000269|PubMed:15590754}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000269|PubMed:15590754}.
Interaction partners:
- Myeloperoxidase
- Lipopolysaccharide-binding protein
- Cathepsin G
- Lactotransferrin
Sequence:
MTWAPDNVRKWSALLLLAIIGTALTAATDPGFVAMISQKGLDFACQQGVVELQKELQAISVPDFSGVFKIKHLGKGSYEFYSMAVDGFHIPNPKIEMLPSDGLRVFIKDASIKINGKWMSRKNFLKAGGNFELSIQGVSISTDLILGSDSSGHITTICSNCDSHIDSVHIKISGSMLGWLIRLFHRKIETSLKNIIYKKICKIVRDSVSSKLQPYLKTLSVITRVDDVTSVDYSLLAPLTTTNQFLEGQLKGEFFWRGHRDPLPIHPPVMRFVPNGAYMVCMGISDYFFNTEVLAYQQSGTLKMTLGGQLLSNNGRFQLNTDFLRTFLPKVAKMFPSMGVQLLISAPVPVHLSIQPSGLSFNPKLETQAFVVLPNASLVPLFVLGMKTNASLEVDAEENRLVGEMKLGSRWLLELKESKFGPFKVEYLEDVINYLVSTLVLPKINERLRRGFPLPLPAGIRFSHFTFYPYQNFLLLEADLHLI
Protein: NAC domain containing protein 50 (ANAC050) (Q9SQX9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that binds to the motif 5'-(C/T)A(C/A)G-3' in the promoter of target genes. Binds also to the 5'-CTTGNNNNNCAAG-3' consensus sequence in chromatin. Can bind to the mitochondrial dysfunction motif (MDM) present in the upstream regions of mitochondrial dysfunction stimulon (MDS) genes involved in mitochondrial retrograde regulation (MRR). Together with NAC051/NAC052 and JMJ14, regulates gene expression and flowering time by associating with the histone demethylase JMJ14, probably by the promotion of RNA-mediated gene silencing.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:26617990}.
Interaction partners:
- Lysine-specific demethylase JMJ14
- Leucine-rich repeat protein kinase family protein
- Sulfite exporter TauE/SafE family protein 1
- F-box/LRR-repeat protein At3g59250
- protein-synthesizing GTPase
- WPP domain-containing protein 3
- Protein GAMETE EXPRESSED 3
Sequence:
MGRESLAVVSSPPSATAPSTAVSATSLAPGFRFHPTDEELVSYYLKRKVLGKPVRFDAIGEVDIYKHEPWDLAVFSKLKTRDQEWYFFSALDKKYGNGARMNRATNKGYWKATGKDREIRRDIQLLGMKKTLVFHSGRAPDGLRTNWVMHEYRLVEYETETNGSLLQDAYVLCRVFHKNNIGPPSGNRYAPFMEEEWADGGGALIPGIDVRVRVEALPQANGNNQMDQEMHSASKDLININELPRDATPMDIEPNQQNHHESAFKPQESNNHSGYEEDEDTLKREHAEEDERPPSLCILNKEAPLPLLQYKRRRQNESNNNSSRNTQDHCSSTITTVDNTTTLISSSAAAATNTAISALLEFSLMGISDKKENQQKEETSPPSPIASPEEKVNDLQKEVHQMSVERETFKLEMMSAEAMISILQSRIDALRQENEELKKKNASGQAS
Protein: Systemic RNA interference defective protein 1 (Systemic RNAi enabling protein) (Q9GZC8)
Organism: Caenorhabditis elegans
Function: Plays a role in RNA-mediated gene silencing by acting cell-autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent. Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11834782, ECO:0000269|PubMed:12970568, ECO:0000269|PubMed:17381285}; Multi-pass membrane protein {ECO:0000269|PubMed:11834782, ECO:0000269|PubMed:12970568, ECO:0000269|PubMed:17381285}. Note=Enriched at the cell periphery and also to the punctate structures of cytoplasm.
Interaction partners:
- Systemic RNA interference defective protein 2
- Piwi domain-containing protein
- Systemic RNA interference defective protein 5
- Tyrosine-protein kinase sid-3
- ENTH domain-containing protein
- DRBM domain-containing protein
- RNA-directed RNA polymerase
- Cuticle collagen rol-6
- RSD-2 domain-containing protein
- Argonaute protein hrde-1
Sequence:
MIRVYLIILMHLVIGLTQNNSTTPSPIITSSNSSVLVFEISSKMKMIEKKLEANTVHVLRLELDQSFILDLTKVAAEIVDSSKYSKEDGVILEVTVSNGRDSFLLKLPTVYPNLKLYTDGKLLNPLVEQDFGAHRKRHRIGDPHFHQNLIVTVQSRLNADIDYRLHVTHLDRAQYDFLKFKTGQTTKTLSNQKLTFVKPIGFFLNCSEQNISQFHVTLYSEDDICANLITVPANESIYDRSVISDKTHNRRVLSFTKRADIFFTETEISMFKSFRIFVFIAPDDSGCSTNTSRKSFNEKKKISFEFKKLENQSYAVPTALMMIFLTTPCLLFLPIVINIIKNSRKLAPSQSNLISFSPVPSEQRDMDLSHDEQQNTSSELENNGEIPAAENQIVEEITAENQETSVEEGNREIQVKIPLKQDSLSLHGQMLQYPVAIILPVLMHTAIEFHKWTTSTMANRDEMCFHNHACARPLGELRAWNNIITNIGYTLYGAIFIVLSICRRGRHEYSHVFGTYECTLLDVTIGVFMVLQSIASATYHICPSDVAFQFDTPCIQVICGLLMVRQWFVRHESPSPAYTNILLVGVVSLNFLISAFSKTSYVRFIIAVIHVIVVGSICLAKERSLGSEKLKTRFFIMAFSMGNFAAIVMYLTLSAFHLNQIATYCFIINCIMYLMYYGCMKVLHSERITSKAKLCGALSLLAWAVAGFFFFQDDTDWTRSAAASRALNKPCLLLGFFGSHDLWHIFGALAGLFTFIFVSFVDDDLINTRKTSINIF
Protein: Signal transducer and activator of transcription 1 (A0A0G2JX93)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Signal transducer and activator of transcription
- Interferon regulatory factor 9
- Tyrosine-protein kinase
- Tyrosine-protein kinase JAK2
- Signal transducer and activator of transcription 3
- Interferon regulatory factor 1
- Histone lysine acetyltransferase CREBBP
- Protein inhibitor of activated STAT, 1
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase
Sequence:
MTYEGDPIPAQRVHLLERATFLIYNLFKKLLIKLPELNYQVKVKASIDNNRRFVLCGTHIKAMSSEESSNGSLSVEFRHLGCHMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSDQLNMLAEKLTVQSNYSDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHSVEPYNKARLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVPRKHVVRLFPAAASLPPQFANRVAAAPPVANLWFLWKSEEGTRYPGTGVGNRHDGTANPTPVLCKGKFFLTAELRPKALGWKFRLELEVSFTCVLFLQRMSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIHNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEHEIKTLEDLQDEYDFKCKTSQNRESEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQSWFTIVAESLQQVRQQLKKLEELEQKFTYEQDPITKNKQVLSDRTFVLFQQLIQRLLVKLQELNYNLKVKVSFDKDVNEKNTVKGSKHFKDLCLALYRFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGNRTNETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKKHLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQSTENLLPMSPEEFDEMSKIVGSEFDSMVSSVAGVFPPWEDLRQAGTASDLESAVRSPEKGLSLSLFLSPPPSPYLRPSPPLSLMSLCFS
Protein: L-galactono-1,4-lactone dehydrogenase, mitochondrial (EC 1.3.2.3) (Q9SU56)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biosynthesis of ascorbate. Catalyzes the final step of ascorbate biosynthesis. Uses L-galactono-1,4-lactone and L-gulono-1,4-lactone as substrates, but not D-galactono-1,4-lactone, D-gulono-1,4-lactone, L-mannono-1,4-lactone or D-galactonic acid. Also active with phenazine methosulfate and 1,4-benzoquinone as electron acceptors. Involved in the regulation of the accumulation of the mitochondrial respiratory complex I. Structural part of one of the plant-specific mitochondrial complex I assembly intermediates, lacking the whole distal (PD) module. Prevents the binding of the plant specific P1 protein (CPN60/HSP60), responsible for the linkage of the proximal (PP) to the distal (PD) module.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:18799460}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- L-galactose dehydrogenase
- Monodehydroascorbate reductase 3
- Probable truncated L-gulonolactone oxidase 7, mitochondrial
- Glutathione S-transferase DHAR2
- L-ascorbate peroxidase 3
- Glutathione S-transferase DHAR1, mitochondrial
- Monodehydroascorbate reductase, chloroplastic/mitochondrial
- L-ascorbate oxidase
- Monodehydroascorbate reductase 4, peroxisomal
- Monodehydroascorbate reductase 2
Sequence:
MLRSLLLRRSVGHSLGTLSPSSSTIRSSFSPHRTLCTTGQTLTPPPPPPPRPPPPPPATASEAQFRKYAGYAALAIFSGVATYFSFPFPENAKHKKAQIFRYAPLPEDLHTVSNWSGTHEVQTRNFNQPENLADLEALVKESHEKKLRIRPVGSGLSPNGIGLSRSGMVNLALMDKVLEVDKEKKRVTVQAGIRVQQLVDAIKDYGLTLQNFASIREQQIGGIIQVGAHGTGARLPPIDEQVISMKLVTPAKGTIELSREKDPELFHLARCGLGGLGVVAEVTLQCVARHELVEHTYVSNLQEIKKNHKKLLSANKHVKYLYIPYTDTVVVVTCNPVSKWSGPPKDKPKYTTDEAVQHVRDLYRESIVKYRVQDSGKKSPDSSEPDIQELSFTELRDKLLALDPLNDVHVAKVNQAEAEFWKKSEGYRVGWSDEILGFDCGGQQWVSESCFPAGTLANPSMKDLEYIEELKKLIEKEAIPAPAPIEQRWTARSKSPISPAFSTSEDDIFSWVGIIMYLPTADPRQRKDITDEFFHYRHLTQKQLWDQFSAYEHWAKIEIPKDKEELEALQARIRKRFPVDAYNKARRELDPNRILSNNMVEKLFPVSTTA
Protein: Palmitoyltransferase ZDHHC1 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 1) (Q8R0N9)
Organism: Mus musculus (Mouse)
Function: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:23687301}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8WTX9}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000250|UniProtKB:Q8WTX9}.
Interaction partners:
Sequence:
MNICNKPSNKTAPEKSVWTAPSQDSGPSPELQGQRSRRNGWSWPPHPLQIVAWLLYLFFAVIGFGVLVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVSIDPADANVRDKSYSGPLPIFNRSQHAHVIEDLHCNLCDVDVSARSKHCSACNKCVCGFDHHCKWLNNCVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNQHFEVLKNHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTTYEYIVQHRPAQEAKETHKELESCPRKVRSIQEMEFYMRTFSHVRPEPSGQARTAALNANPSQFLATQGQVEPPLPSSSDTLALPPRIQPQKKRKRRVYRLPRSGVLDRELPLPRLRETGTPSRRSSSSSDSTSASPVHAGGSAGAYYSASAESMEEIPVAQTRLGSAALGAPGARGRESGLALQARSPAVFVSPSSGEPGTPGGGDGLP
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (K7EIY6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSN
Protein: Erythrocyte membrane protein 1, PfEMP1 (Q8IBD8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MARPSGSAGGGAGGKKEDESAKHMFDRIGKEVYDEIVKKDVGAEAYKEALKGKLQKAASTISELAGITDTCKRVQKYYEHFNVGAARGKRYPCTNLKRNTNEERFSNTLGGQCTNKKMKCSNGEGACAPYRRLHLCHHNLETIETTSKTSTDTLLAEVCMAAYYEGESLTRQHVKHKLTNSDVNINICTVLARSFADIGDIVRGKDLFYGNTYESTQRKVLDDNLKTIFENIKKSDTKLTKLNDEQIREYWWEANRETVWKAITCSDDLKNSSYFRTTACAGTRTNDKCRCTKSSGAKVDDQVPTYFDYVPQYLRWFEEWAEDFCRKKNKKIKDVKTNCRDEKEKYCSGNGYDCRKTIYKKGKLVIGEHCTNCSVWCRLYEKWIDNQKKEFLKQKNKYTKEMKKYKNGESRSGSDGNKYDGYESKFYKILKGGYEKVNNFLELLNEEKECKGISEVKEKIDFKTVDNGFDKNINSPGTFYHSEYCKPCPGCGVKLEDNVWKEKKGGTCDRRKLYTTITNAESTNIDVLSFGDKREDRETKLKAFCPKTNGDTTNGVHGSGDCGGTNSDPSLCEKWKCYKHEHVQKVKNGEDDDDDDDVDGNYVKNGGGLCILPNPKKKEEEKTKKSEKEPDEFQKTFNEFFYFWIGRFLNDSMYWRGKVGGCLKNKSEKCKNECNTKCDCFLKWITQKKTEWDKIVQHFKKQDFGPQVENGGSGMLGGLMSCPDFVLKTVLKLEDLFENIKSGYGNVKETEGINKILDEEQKKNKEEADDGVGGGGIDFAAFAVSCTEDGVAKQNTTIDKLLNQEDKDATECKKCEEQAARARSAETNDEPPGSPPRSEEVESEEEEEEEEEDEDHGPDDEEAKTAEGAGEGEGAEAPKEVVPGPKDAEVPAATTTTQNDVKVCKTVAEALKTSLTDACTLKYVTGKNYGWKCIPTSGGDKTATSEGSSESGRRIAKRSVETSGSSGGSGATGKSDGSICIPPRRRKLYLGGFKRLTDGTSVSSEPTTATSSPSPKGDSLLTAFVESAAVETFFLWHKYKAENTKTQSESLLLPPQPVPVVDNDNPQNQLLSGKIPPDFLRQMFYTLGDYRDILFSGSKDEKSSTYNDILKGDKEMKAKEEKIKEKITSFFQNGDSQPPNGKHVTQTSDKTPQQTWWQAHGPDIWNGMVCALTYKEDTSGAKGESAKIEQDNEVETKLKEKLQKDKDYHYDTVTLKDEQSGGDSTLNNPKLKNFVEIPTYFRYLHEWGQNFCKERKKRLQKIEGDCRVEDGSKNCSGYGEDCKDNLLNKPYDTLPSFNCRSCGIECRKYKNWIKGKRKEFEEQKQEYSKQKTDAEGNNNGNEFYTKLEECPEVKDFLQKLEPCKKDNGEGKTIFQDEAEAFGHKKYCDPCSQFKIDCKNGKCKSGDTKVNCNRKNTIDATEIENIKTNTKEVTMLVSDGNKKFFHGLNKCRFAGIFEGIRKDEWKCGEICGYNVCKPINVNDLKVNGTQNQNQIIIITAFVKLWVEYFFEDYKKIKHKISHCINSGNKSTCTNDCPNKCKCVKEWVEEKTNEWKTLKERFNDQYKNDSQIYPVRSILEELIPQIDVTIDKKNYTSLEELEKTLKCNGSDKSQNGTQKDIIECLLGNLKDKIETYPSSTSGSEQCTTPPSNLDDYTHTDDDDAHEKEKQSPKFCKDGVVPEKSKVPESEDDSTKTSESTKKGESSIEDIFKTCPYDNDTCNNYRNKNNIGCPPKTHHTNLNHWKNTLIKFDKGKSTDMNDGILIPPRRRQLCFRNIRKFHGRIDSEQKFREYFIADVYNEAKQLSRYYAKDNEKILEAIKNSFADYGNIVKGDDMLGDGLSEIIQKILVKLNEKKSNAEKLALQQLWENNKKYVWYVMLCGYKQGNHSVKNIENECTLPTTESEDQFLRWFQEWGKIFCTRKKELKEEVKQQCSNSICTKHKTIENRCQKACKKYSNFISTNQNVYLLLKSQYDKNYKRDKTGGREAHDYLKIKCKNGKCDCIVQNFIDDDKWEKPYETLDKNLKSKCECIKPKPTCTTNTAETEKKKEEENDQLPAPKEQTDPGSDTPPPLPTPSKPDELLPIQADQPFDPTILQTTIPFGIALALGSIAFLFLKKKTKSTIDLLRVINIPKSDYDIPTKLSPNRYIPYTSGKYRGKRYIYLEGDSGTDSGYTDHYSDITSSSESEYEELDINDIYAPRAPKYKTLIEVVLEPSGNNTTASGNNTTASGNNTTASGNNTTASDTQNDIQNDGIPSSKITDNEWNTLKDEFISQYLPNTEPNNNYRSGNSPTNTNITTTSRHNMEEKPFITSIHDRNLYTGEEISYNINMSTNSMDDPKYVSNNVYSGIDLINDTLSGNKHIDIYDEVLKRKENELFGTNHTKKNTSTNSVAKLTNSDPIHNQLELFHKWLDRHRDMCEKLKNDNERLAKLKEEWENETHSGDINSGIPSGKLSDIPSDNNIHSDIHPSDIHSGKLSDIPSGKQVLNTDVSIQIHMDNPKTTNEFTYVDSNPNQVDDTYVDSNPDNSSMDTILEDLEKYNEPYYDVQDDIYYDVHDHDASTVDSNAMDVPSKVQIEMDVNTKLVKEKYPISDVWDI
Protein: DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed] (Q99LZ3)
Organism: Mus musculus (Mouse)
Function: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Subcellular location: Nucleus {ECO:0000269|PubMed:16338220}. Chromosome {ECO:0000250|UniProtKB:Q7ZT48}. Cytoplasm {ECO:0000269|PubMed:16338220}.
Interaction partners:
- DNA replication complex GINS protein PSF2
- Cell division control protein 45 homolog
- DNA replication complex GINS protein PSF3
- DNA replication licensing factor MCM4
- DNA replication complex GINS protein PSF1
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM2
Sequence:
MTEVLDLHGQDSDGGSEEMVLTPAELIEKLEQAWMNEKFAPELLESKAEIVECVMEQLEHMEENLRRAKKGDLKVSIHRMEMERIRYVLSSYLRCRLMKIEKFFPHILEKEKVRSEGEPSSLSPEEFVFAKEYMDHTETHFKNVALKHMPPNLQKVDLLRAVPKPDLDSYVFLRVKERQENILVEPEADEQRDYVIDLEVGSQHLIRYKTIAPLVASGAVQLI
Protein: Transcription factor bHLH13 (Basic helix-loop-helix protein 13) (AtbHLH13) (bHLH 13) (Transcription factor EN 39) (bHLH transcription factor bHLH013) (Q9LNJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Protein TIFY 10A
- Protein TIFY 5A
- Protein TIFY 3A
- Protein TIFY 6A
- Protein TIFY 10B
- Bidirectional sugar transporter SWEET15
- Protein TIFY 11A
- Protein TIFY 7
- Protein TIFY 9
- Protein TIFY 11B
Sequence:
MNIGRLVWNEDDKAIVASLLGKRALDYLLSNSVSNANLLMTLGSDENLQNKLSDLVERPNASNFSWNYAIFWQISRSKAGDLVLCWGDGYCREPKEGEKSEIVRILSMGREEETHQTMRKRVLQKLHDLFGGSEEENCALGLDRVTDTEMFLLSSMYFSFPRGEGGPGKCFASAKPVWLSDVVNSGSDYCVRSFLAKSAGIQTVVLVPTDLGVVELGSTSCLPESEDSILSIRSLFTSSLPPVRAVALPVTVAEKIDDNRTKIFGKDLHNSGFLQHHQHHQQQQQQPPQQQQHRQFREKLTVRKMDDRAPKRLDAYPNNGNRFMFSNPGTNNNTLLSPTWVQPENYTRPINVKEVPSTDEFKFLPLQQSSQRLLPPAQMQIDFSAASSRASENNSDGEGGGEWADAVGADESGNNRPRKRGRRPANGRAEALNHVEAERQRREKLNQRFYALRSVVPNISKMDKASLLGDAVSYINELHAKLKVMEAERERLGYSSNPPISLDSDINVQTSGEDVTVRINCPLESHPASRIFHAFEESKVEVINSNLEVSQDTVLHTFVVKSEELTKEKLISALSREQTNSVQSRTSSGR