wanglab/gogpt-training-data huggingface dataset:
Protein: Rosmarinate synthase (MoRAS) (EC 2.3.1.140) (Hydroxycinnamoyl-CoA:hydroxyphenyllactate hydroxycinnamoyltransferase) (G0LD36)
Organism: Melissa officinalis (Lemon balm)
Function: Catalyzes the formation of rosmarinic acid using caffeoyl-CoA and 3.4-dihydroxyphenyllactate as substrates. Can also use 4-coumaroyl-CoA and 4-hydroxyphenyllactate as substrates. Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid.
Interaction partners:
Sequence:
MRIDIKDSTMVKPAAETPGGSVWLTNLDLLSPANYHTLSVHFYHHDGSENFFDAAALKEALSRALVDFYPYAGRLKLKDNRLEIDCNGEGVLLVEAESDGALAELGEFAPRPDLNLIPQVDYAKGISTYPLMLFQLTRFKCGGVGLGVANEHHLSDGVAALHFINTWAHLARGVPAPSPPPVFDRRSLSARNPPKPQFSHAEYQPPPTLPTPLTDTAIAYSKLKVTRDQLGALKAKCLAGDPSGKPRSTFEVLAGHIWRCVCAARGLPEDQETKLHIPFDGRAKLRLPPGYFGNAIFFATPVATCGEIESNSLAHAVKRVGDAIARLDEDYLRSSIDFLELQEDISKLAQGAHSFRCPNLWVISWVRLPVYEPDFGWGKAVYMGPWAAPFEGKSYLLPNPDNDGSLFVAITLHTQHMERFEKLFYEI
Protein: LANA (E5LC01)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGNDLHLQPRRKHVADSVDGRECGPHTLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLSPVTTSSSPIPPSHPVSPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPPEPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWATESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKECSENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEDDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGDGNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPLQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQQEPQQREPQQQEPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQQDEQQQQDEQQQQDEQQQEEQEQQEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQELEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETVEEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPHRPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQWKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHLGPDQSPITYCVYVYCQNKDTSKKVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT
Protein: Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: NT-proBNP (NT-pro-BNP) (NT-proBNP(1-76)); proBNP(3-108); Brain natriuretic peptide 32 (BNP(1-32)) (BNP-32) (Brain natriuretic peptide) (BNP); BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32) (des-SerPro-BNP) (proBNP(79-108)); BNP(3-30); BNP(3-29); Brain natriuretic peptide 29 (BNP(4-32)); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)] (P16860)
Organism: Homo sapiens (Human)
Function: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.
Subcellular location: [NT-proBNP]: Secreted {ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:25339504}. Note=Detected in blood. {ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:25339504}.; SUBCELLULAR LOCATION: [proBNP(3-108)]: Secreted {ECO:0000269|PubMed:17367664}. Note=Detected in blood. {ECO:0000269|PubMed:17367664}.; SUBCELLULAR LOCATION: [Brain natriuretic peptide 32]: Secreted {ECO:0000269|PubMed:17367664, ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:1914098, ECO:0000269|PubMed:25339504}. Note=Detected in blood. {ECO:0000269|PubMed:17367664, ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:1914098, ECO:0000269|PubMed:25339504}.; SUBCELLULAR LOCATION: [BNP(3-32)]: Secreted {ECO:0000269|PubMed:17367664}. Note=Detected in blood. {ECO:0000269|PubMed:17367664}.
Interaction partners:
- Atrial natriuretic peptide receptor 3
- Atrial natriuretic peptide receptor 1
- Natriuretic peptides A
- Atrial natriuretic peptide receptor 2
- Insulin-degrading enzyme
- C-type natriuretic peptide
- Troponin I, cardiac muscle
- C-reactive protein
- Angiotensin-converting enzyme
- Troponin T, cardiac muscle
Sequence:
MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH
Protein: Nitrate/nitrite response regulator protein NarP (P31802)
Organism: Escherichia coli (strain K12)
Function: This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins.
Interaction partners:
- Nitrate/nitrite sensor protein NarQ
- Nitrate/nitrite sensor protein NarX
- Signal transduction histidine-protein kinase/phosphatase UhpB
- Ferredoxin-type protein NapF
- Cytochrome c-552
- Putative HTH-type transcriptional regulator YhjB
- TorCAD operon transcriptional regulatory protein TorR
Sequence:
MPEATPFQVMIVDDHPLMRRGVRQLLELDPGSEVVAEAGDGASAIDLANRLDIDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQRGAQ
Protein: Outer envelope pore protein 21, chloroplastic (Chloroplastic outer envelope pore protein of 21 kDa) (gOEP21) (Q9SM57)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Voltage-dependent rectifying anion channel that facilitates the translocation between chloroplast and cytoplasm of phosphorylated carbohydrates such as triosephosphate, 3-phosphoglycerate and inorganic phosphate (Pi) depending of ATP to triosephosphate ratio in the plastidial intermembrane space; in high triosephosphate/ATP conditions (e.g. photosynthesis), export of triosphosphate from chloroplast (outward rectifying channels), but in high ATP/triosephosphate conditions (e.g. dark phase), import of phosphosolutes (inward rectifying channels).
Subcellular location: Plastid, etioplast membrane {ECO:0000269|PubMed:10523295}; Multi-pass membrane protein {ECO:0000269|PubMed:10523295}. Plastid, chloroplast outer membrane {ECO:0000269|PubMed:10523295}; Multi-pass membrane protein {ECO:0000269|PubMed:10523295}. Note=Present in non-green root plastids.
Interaction partners:
Sequence:
METSLRYGGDSKALKIHAKEKLRIDTNTFFQVRGGLDTKTGQPSSGSALIRHFYPNFSATLGVGVRYDKQDSVGVRYAKNDKLRYTVLAKKTFPVTNDGLVNFKIKGGCDVDQDFKEWKSRGGAEFSWNVFNFQKDQDVRLRIGYEAFEQVPYLQIRENNWTFNADYKGRWNVRYDL
Protein: RNA-binding protein RMD9-like, mitochondrial (P38330)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in the processing or stability of mitochondrial mRNAs.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P53140}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53140}; Matrix side {ECO:0000250|UniProtKB:P53140}.
Interaction partners:
- BEM1-interacting protein 1
Sequence:
MIRLAQQTQVLKGKPPNQFVPHPTKNSLTHPMKFNGTIAMEHHEHNYAIPYTPATFNNPALATYQVSPANHFVPHFGGNIGANNNNHLAQNNSNNSNNHHNNNRNHHHNNNRNHHQNNHNHSKYNNSNQGNSISPDSPWFHKVCAFEDCVSQTLYMSQTPRRQNMKHHSEHPNSNANPLFWDSIGRAMGLYHDLLTTPELNSDRVSKLVHLLHNGLRANRNQLTRMNKKPDYDSQSFHKEMTNYLCKSLREISEDVLNGKVELNEYGAMHLITAFKELLLFEEAVDIWKAAINGQNTYTSNIFLNPRVVGVILPILYDNGVSYPEIQALYEKSSSMINYFHPNLSVGMIRASLSASENDMALKLFQKLCQESTEMKYGYLIETHLSFIGECKDLNVAQTFFDKALNDEMPYKIDLQVSYVKSFLRNIWSQTRDFNHIYQIWYKSSLHYGRNVNHGISSSLNDTFFDIFFENYAVDKMQGFQTLQNIIQTYNNIKHIDEPFFNIILAKCTVWHDRSILEYIDKSYEAYHIPKTIVAYRILLKSMGSVDDASNAEILQRWMDLIRKSDEIGQRFIANADWAALRDATVTWTQNDRDSKKSNMNSTQISRTATPSPSLTPMDTPAPEHLFNNPQNPMDFYSHPALQAATASGAFDEFAAEAASSSIPVDGRMVLYLKIVKRYSPYCRDSRQLARLTTGTAVKYSVLQEVLNQFQTLIVNDIPIPELHNLKPTCV
Protein: PYK10-binding protein 1 (Jacalin-related lectin 30) (Jasmonic acid-induced protein) (O04314)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inhibitor-type lectin that may regulate the correct polymerization of BGLU23/PYK10 upon tissue damage. Activates BGLU21, BGLU22 and BGLU23.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15919674}.
Interaction partners:
- Beta-glucosidase 23
- Protein TRAUCO
- TSA1-like protein
- Beta-glucosidase 21
- Beta-glucosidase 22
- Transcription factor NAI1
- FIP1[V]-like protein
- Alpha/beta-Hydrolases superfamily protein
- Expressed protein
- Glucosidase 2 subunit beta
Sequence:
MAQKVEAQGGKGANLWDDGSTHDAVTKIQLAAGIDGIQYVQFDYVKNGQPEQAPLRGTKGRVLPADPFVINHPDEHLVSVEGWYSPEGIIQGIKFISNKKTSDVIGSDEGTHFTLQVKDKKIIGFHGSAGGNLNSLGAYFAPLTTTTPLTPAKQLTAFGSDDGTVWDDGAYVGVKKVYVGQAQDGISAVKFVYDKSPEEVTGEEHGKSTLLGFEEFVLDYPSEYITAVDGTYDKIFGSDGSVITMLRFKTNKQTSPPFGLEAGTVFELKEEGHKIVGFHGRADVLLHKIGVHVRPLSN
Protein: Probable solute-binding protein (Q9I2T3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable binding protein component of ABC transporter
- Inner membrane ABC transporter permease protein YejB
- Probable permease of ABC transporter
- ABC-type dipeptide transporter
- Probable binding protein component of ABC transporter
- Inner membrane ABC transporter permease protein YejB
- Probable permease of ABC transporter
- Enoyl-[acyl-carrier-protein] reductase FabI
- ABC-type dipeptide transporter
Sequence:
MRRLSFLILGLAVSLPSFAAITQSHGYAQFGTLKYPANFQHFDWTNPDAPKGGTLRLMASGSFDTLNPYTLKGTSPIGTGDFLQYGVNELNEPLMVGTGLYDPSGDEPASSYGLIAKSVEYAENRSWVVFNLRPEARFHDGRPITASDVAFSYRTLVKQGHPMYRTYLQEVKRVDILTPHRVRFVLRRSGNPLLILRLGELPVLPQHYWKDRDFRATTFTAPLGSGPYRIVEVDPGRRLVFERVKGWWGEKLPVNRGKYNFDRVVVDFYRDNGVAFEAFKAGEFDFYIEHQAKNWLNNYRFPAVLRGDVIRTEIPHQIPSQTQALFMNTRRAVFKERALRQALGEMFDFEWTNRALFSNSYLRSRSYYPNSEFAASGVPEGQEWLYLSPYRKQLPAQLFKQPFSLPTTEGRGIPRETLRHALGLLADAGWKLSGDRLLNKKGEPLRFEILLVNPSLERILQPYRENLASIGIDARLRTVDRAQYKQRLDQFDYDMILMTLPQTLSPGLEQWQYFHSSQVKVKGSKNYAGIANPVVDAMLNRLLGAHSRDEQVAAARALDRTLLWQYYSIPNWYLNSHRLAYRNRFAFVATPPYTLGLRAWWQKNLETSR
Protein: GH28017p (Q8T0I5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDCNRILRIAASFLTAPMVKLLLWTAHQELLLVQHHWYVCTRIWPNADRELEQYEMIPPAPVRMSDLNTKILTNTRLGYPALPFDDLGCPPGTRGLRPHPHDVHKYLRCGIGVKPQVEQCPRGHIFDGSSSVCVYSDSPRTSSSSFTSAEIQVNYLLCPVGAVGQFVHPFDQTKFLSCKDGKSAVQNCQPNYVFSISRRYCQLKAQLAFTDYVTLIISEISYEYSLILNACPGNINGIFLYPYDAKKYVQCSSGGRMSILSCGPQMAFSVSQRSCLPSHQVHISDRVQFWQEVQVQTTYTSQDLRGNVQSQLSSLRSCPPNVQKNYPYPFHAGHYVRCQYGALEIICCPTGQLYSLSQRQCVPRSLLSAHDYLDYSYISAELSTEFMVDRSTLSCPPQAQGLYLHPFDCTKYVRCWNQQTFIESCVVCAYAILRTIK
Protein: Uncharacterized protein C2orf74 (A8MZ97)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSFETTAITFFIILLICLICILLLLVVFLYKCFQGRKGKETKKVPCTDANGGVDCAAAKVVTSNPEDHERILMQVMNLNVPMRPGILVQRQSKEVLATPLENRRDMEAEEENQINEKQEPENAGETGQEEDDGLQKIHTSVTRTPSVVESQKRPLKGVTFSREVIVVDLGNEYPTPRSYTREHKERK
Protein: Histone-lysine N-methyltransferase SUVR5 (EC 2.1.1.-) (C2H2 zinc finger-SET histone methyltransferase) (Protein C2H2 SET) (Protein SET DOMAIN GROUP 6) (Suppressor of variegation 3-9-related protein 5) (Su(var)3-9-related protein 5) (O64827)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone methyltransferase that functions together with its binding partner LDL1/SWP1 as one of the regulators of flower timing in Arabidopsis. Mediates H3K9me2 deposition and regulates gene expression in a DNA methylation-independent manner. Binds DNA through its zinc fingers and represses the expression of a subset of stimulus response genes. May represent a novel mechanism for plants to regulate their chromatin and transcriptional state, which may allow for the adaptability and modulation necessary to rapidly respond to environment or developmental cues.
Subcellular location: Nucleus {ECO:0000269|PubMed:17224141}. Chromosome {ECO:0000250|UniProtKB:Q5DW34}. Note=Associates with euchromatic regions. {ECO:0000250|UniProtKB:Q5DW34}.
Interaction partners:
- Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM
- Lysine-specific demethylase ELF6
- Histone H4
- Ubiquitin-ribosomal protein eL40z fusion protein
- Ubiquitin-ribosomal protein eL40y fusion protein
- Histone-binding protein MSI1
- WD-40 repeat-containing protein MSI4
- Multiple organellar RNA editing factor 1, mitochondrial
- WD-40 repeat-containing protein MSI5
- WD-40 repeat-containing protein MSI3
Sequence:
MEVKMDELVLDVDVEEATGSELLVKSEPEADLNAVKSSTDLVTVTGPIGKNGEGESSPSEPKWLQQDEPIALWVKWRGKWQAGIRCAKADWPLTTLRGKPTHDRKKYCVIFFPHTKNYSWADMQLVRSINEFPDPIAYKSHKIGLKLVKDLTAARRYIMRKLTVGMFNIVDQFPSEVVSEAARDIIIWKEFAMEATRSTSYHDLGIMLVKLHSMILQRYMDPIWLENSFPLWVQKCNNAVNAESIELLNEEFDNCIKWNEVKSLSESPMQPMLLSEWKTWKHDIAKWFSISRRGVGEIAQPDSKSVFNSDVQASRKRPKLEIRRAETTNATHMESDTSPQGLSAIDSEFFSSRGNTNSPETMKEENPVMNTPENGLDLWDGIVVEAGGSQFMKTKETNGLSHPQDQHINESVLKKPFGSGNKSQQCIAFIESKGRQCVRWANEGDVYCCVHLASRFTTKSMKNEGSPAVEAPMCGGVTVLGTKCKHRSLPGFLYCKKHRPHTGMVKPDDSSSFLVKRKVSEIMSTLETNQCQDLVPFGEPEGPSFEKQEPHGATSFTEMFEHCSQEDNLCIGSCSENSYISCSEFSTKHSLYCEQHLPNWLKRARNGKSRIISKEVFVDLLRGCLSREEKLALHQACDIFYKLFKSVLSLRNSVPMEVQIDWAKTEASRNADAGVGEFLMKLVSNERERLTRIWGFATGADEEDVSLSEYPNRLLAITNTCDDDDDKEKWSFSGFACAICLDSFVRRKLLEIHVEERHHVQFAEKCMLLQCIPCGSHFGDKEQLLVHVQAVHPSECKSLTVASECNLTNGEFSQKPEAGSSQIVVSQNNENTSGVHKFVCKFCGLKFNLLPDLGRHHQAEHMGPSLVGSRGPKKGIRFNTYRMKSGRLSRPNKFKKSLGAVSYRIRNRAGVNMKRRMQGSKSLGTEGNTEAGVSPPLDDSRNFDGVTDAHCSVVSDILLSKVQKAKHRPNNLDILSAARSACCRVSVETSLEAKFGDLPDRIYLKAAKLCGEQGVQVQWHQEGYICSNGCKPVKDPNLLHPLIPRQENDRFGIAVDAGQHSNIELEVDECHCIMEAHHFSKRPFGNTAVLCKDISFGKESVPICVVDDDLWNSEKPYEMPWECFTYVTNSILHPSMDLVKENLQLRCSCRSSVCSPVTCDHVYLFGNDFEDARDIYGKSMRCRFPYDGKQRIILEEGYPVYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILDIDANINDIGRLMEEELDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYGRRPVPSEQENEHPCHCKATNCRGLLS
Protein: Surfeit locus protein 4 homolog (Q18864)
Organism: Caenorhabditis elegans
Function: Endoplasmic reticulum cargo receptor that mediates the export of the yolk proteins from intestinal cells by recruiting cargos into COPII vesicles to facilitate their secretion. Required for the endoplasmic reticulum export of the yolk protein vit-2, which is synthesized as a lipoprotein complex, from intestinal cells. Involved in endoplasmic reticulum exit sites (ERES) organization.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29643117}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localizes at endoplasmic reticulum exit sites (ERES). {ECO:0000269|PubMed:29643117}.
Interaction partners:
- GOLD domain-containing protein
- ERGIC-53-like protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Golgi SNAP receptor complex member 1
- Uncharacterized protein
- Suppressor/enhancer of lin-12 protein 9
- Transmembrane 9 superfamily member
- Peptidase M20 dimerisation domain-containing protein
Sequence:
MNQFRAPGGQNEMLAKAEDAAEDFFRKTRTYLPHIARLCLVSTFLEDGIRMYFQWDDQKQFMQESWSCGWFIATLFVIYNFFGQFIPVLMIMLRKKVLVACGILASIVILQTIAYHILWDLKFLARNIAVGGGLLLLLAETQEEKASLFAGVPTMGDSNKPKSYMLLAGRVLLIFMFMSLMHFEMSFMQVLEIVVGFALITLVSIGYKTKLSAIVLVIWLFGLNLWLNAWWTIPSDRFYRDFMKYDFFQTMSVIGGLLLVIAYGPGGVSVDDYKKRW
Protein: Glucose-dependent insulinotropic receptor (G-protein coupled receptor 119) (Q7TQP3)
Organism: Mus musculus (Mouse)
Function: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Pro-glucagon
- Gastric inhibitory polypeptide
- Pro-opiomelanocortin
- VIP peptides
- G-protein coupled receptor 55
- Pituitary adenylate cyclase-activating polypeptide
- Natriuretic peptides A
- N-arachidonyl glycine receptor
- Free fatty acid receptor 1
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
Protein: Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Dilatory protein) (A1Z7Z9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cilium-specific protein with a role in cilium/flagellum formation. May be involved in transport of components into the growing cilium. In germ cells and sensory neurons, plays a role with Cby in the building of the transition zone necessary for the formation of the ciliary cap and for the correct elongation of the axoneme.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21750193}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21750193, ECO:0000269|PubMed:27646273}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27646273}. Note=Co-localizes with the pericentriolar material (PCM) protein cp190 at centrosomes in undifferentiated sensory neurons (PubMed:21750193, PubMed:27646273). Localizes to the ciliary base, including the basal body and transition zone in sensory neurons and germ cells (PubMed:21750193, PubMed:27646273). {ECO:0000269|PubMed:21750193, ECO:0000269|PubMed:27646273}.
Interaction partners:
- Centrosomal protein Cep290
- FI07242p
- Serine/threonine-protein kinase PLK4
- GH21622p
Sequence:
MDLCLKGSQINLATRQKTKPKYTSRSLTTLHNPCPHFRPRSANFLQQRSRSSPFLGRPQSADPKFGRRLSNYFVEKELRNGGKRQVSSNDLLKSLLEEPIKRSWLCRSTCNSSESDYSLHKRTPDSSEEGEQFLVNMPVGEKVKSYSSYSGNQGLSNGALLQRTAKPDLPGRVSFSKPNMHADLDSSDCDNDKQEVRPSISAPGPLTLPSFLSKVEQADPVGQKKSVHFGSTAAEGEVLAETYEYPKCPSENCTCSTRSSSTTSTNEASASDVKCACDAPSCRFMESSKQVEPTSPTPTLPKAPSSELDVIREYKQAVEGVQVVKNHLGTDTLNNIEILPNYLDKYASPTKEKQNNLSETKNMATNSSAVNNGSVVYRPVGNPRNFGAENNFLPAVQDDRRSFANGSSDGVINNYLKVASTPPFVGKKKENVKPASADPIARSSKSKVTKSTINPAPLGKMKKAISVGSLREERKLSEYNLDKVDSWMSMQDQKQYDGKHKPGLEDLDEAQDNDTASQLSLKSNEDSRDSTYDEIVSVIKEIEEDKKRDNFSEGIPSELNLNLDSRCETADTVTVSEGKVPESGDKYKDILAYLNNVESSCDKTLMETRRSIPDSNRSEVEFVVEPDVTDEVPKLSELLMLPNHQLARRVIALSLRANELANAIHMSKEHVFQLRGEKQKSLRAEKSTAAAKLRDQKKHYEEVVTRHQGFIEQLLKDKGSLCEKVAALTRRLESQNQAWEHRLETELARTKETTMAGEKIRRERWVRENTKKIKELTVKGLEAEINKMNCDHQREVTELKRTHQMQLLDALEEARTKHEQIETSIRESCAQDREAIIEKERTAIRERFERQLEEEQRTQAEQRQKLTEEFAAERDRLQSELRQRENEHQARRQEALREQEQELEQAKFEMQERMAKQEEKYQNRVNTIEQQYQADFELWKTEHENKTKLAQAEKENAIRQHYRAERDRQLDELVVRMEADALQHKEEHELKMNRLKEKYEKDLVLAESVEKSLREKYAETRGKLAEADAQVRNSQAEVKQLQLELSHSKKMCGDIIMERDRLRDNLNADIQSELGVLNERHKQEMDQLQKRVHQTIQRQEETIEILKGDNDALRQQCLKLNAVIRQQRKDYCVK
Protein: H2-O alpha (Histocompatibility 2, O region alpha locus) (Q9QWV1)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Class II histocompatibility antigen, M alpha chain
- Histocompatibility 2, O region beta locus
- H-2 class II histocompatibility antigen gamma chain
- H2-M beta 2
- T-cell surface glycoprotein CD4
- Class II histocompatibility antigen, M beta 1 chain
- H-2 class II histocompatibility antigen, E-B beta chain
- H-2 class II histocompatibility antigen, A beta chain
- T-cell surface glycoprotein CD3 zeta chain
- Histocompatibility 2, M region locus 2
Sequence:
MVLFVELVPVLLTAMSFLSPRGVRAIKADHMGSYGPAFYQSYDASGQFTHEFDGEQIFSVDLKNEEVVWRLPEFGDFAHSDFQSGLMSISMIKAHLDILVERSNRTRAVSVPPRVTVLPKTRVELGKPNVLICIVDDIFPPVINVTWLRNSQPITKGVAQTSFYSQPNHRFRKFHYLTFVPSAEDVYDCKVEHWGLDTPLLQHWEPQVLTPPPDTIETLICGLGLVLGLMGCLLGTVLMITGTRRPSIRR
Protein: Heat shock transcription factor 1 (Q9HAV2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
EKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPXRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
Protein: Zinc finger protein 330 (Nucleolar autoantigen 36) (D6R9C8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MPKKKTGARKKAENRREREKQLRASRSTIDLAKHPCNASMECDKCQRRQKNRAFCYFCNSVQKLPICAQCGKTKCMMKSSDCVIKHAGVYSTGLAMVGAICDFCEAWVCHGRKCLSTHACACPLTDAECVECERGVWDH
Protein: Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein) (Q14746)
Organism: Homo sapiens (Human)
Function: Required for normal Golgi morphology and function.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 5
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 4
- Conserved oligomeric Golgi complex subunit 7
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 3
- Syntaxin-5
- Golgi SNAP receptor complex member 2
- Coatomer subunit beta
Sequence:
MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNPGNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREIAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISAALEDSQSSFSACVPSLSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPSGGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP
Protein: Splicing factor U2af large subunit (U2 auxiliary factor 65 kDa subunit) (U2 small nuclear ribonucleoprotein auxiliary factor large subunit (U2 snRNP auxiliary factor large subunit)) (F4JQG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364135}.
Interaction partners:
Sequence:
MSEFEDHEGNGTVADAIYDEENGGRDGEIEDQLDSKPKRESRDHERETSRSKDREREKGRDKDRERDSEVSRRSRDRDGEKSKERSRDKDRDHRERHHRSSRHRDHSRERGERRERGGGRRSRRSRSRSKDRSERRTRSRSPSKSKQRVSGFDMAPPASAMLAAGAAVTGQVPPAPPTLPGAGMFPNMFPLPTGQSFGGLSMMPIQAMTQQATRHARRVYVGGLSPTANEQSVATFFSQVMAAVGGNTAGPGDAVVNVYINHEKKFAFVEMRSVEEASNAMSLDGIIFEGAPVKVRRPSDYNPSLAATLGPSQPSPHLNLAAVGLTPGASGGLEGPDRIFVGGLPYYFTESQVRELLESFGGLKGFDLVKDRETGNSKGYAFCVYQDLSVTDIACAALNGIKMGDKTLTVRRANQGTMLQKPEQENVLLHAQQQIAFQRVMLQPGAVATTVVCLTQVVTEDELRDDEEYGDIMEDMRQEGGKFGALTNVVIPRPSPNGEPVAGLGKVFLKYADTDGSTRARFGMNGRKFGGNEVVAVYYPEDKFEQGDYGA
Protein: mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) (Q4FKP8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nuclear cap-binding protein subunit 2
- Cap-specific mRNA
- Transcription initiation protein, putative
- RNA guanylyltransferase
Sequence:
MNCRKRGESVTLMESLRTAASYDQVVKKRAGDMKSKETPFRFFSNYVKKCLIQCALDHIKVTTGRRDAIVLDLASGRGGDLGKWLHCQSPELSFATAKLPRERLTKAAYVECYDVSPECIAEAESRYKKIAPDTVCRCSFTVKDCFSEDFLLRELPLTQHFGKFDIVSIQFAFHYACDTLERIDMLLGAIARALAPEGVFIATTVDEEVLAKRVAANRMESKGLFSIHFDSEPQFEYDRLVVGTRYRFNLDGFVDCDEYVVPLDYVRDCAKQHGLEEMVKFSKHFGSFYETYKDDPSKNKERYLVGGEMELATLYRSLCFRKAS
Protein: RAB5C, member RAS oncogene family (B0BNK1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQNAAGAPGRNRGVDLQESNPASRSQCCSN