wanglab/gogpt-training-data huggingface dataset:
Protein: Probable LRR receptor-like serine/threonine-protein kinase At2g23950 (EC 2.7.11.1) (Q0WVM4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Protein S40-2
- Phosphoglycolate phosphatase
- Cyclin-dependent protein kinase inhibitor SMR16
- E3 ubiquitin-protein ligase JMJ24
- Uncharacterized protein
- B3 domain-containing protein At2g24670
- Eukaryotic aspartyl protease family protein
- Nuclear envelope-associated protein 2
- Transmembrane protein
- Transmembrane protein
Sequence:
MVVMKLITMKIFSVLLLLCFFVTCSLSSEPRNPEVEALINIKNELHDPHGVFKNWDEFSVDPCSWTMISCSSDNLVIGLGAPSQSLSGTLSGSIGNLTNLRQVSLQNNNISGKIPPEICSLPKLQTLDLSNNRFSGEIPGSVNQLSNLQYLRLNNNSLSGPFPASLSQIPHLSFLDLSYNNLRGPVPKFPARTFNVAGNPLICKNSLPEICSGSISASPLSVSLRSSSGRRTNILAVALGVSLGFAVSVILSLGFIWYRKKQRRLTMLRISDKQEEGLLGLGNLRSFTFRELHVATDGFSSKSILGAGGFGNVYRGKFGDGTVVAVKRLKDVNGTSGNSQFRTELEMISLAVHRNLLRLIGYCASSSERLLVYPYMSNGSVASRLKAKPALDWNTRKKIAIGAARGLFYLHEQCDPKIIHRDVKAANILLDEYFEAVVGDFGLAKLLNHEDSHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGMRALEFGKSVSQKGAMLEWVRKLHKEMKVEELVDRELGTTYDRIEVGEMLQVALLCTQFLPAHRPKMSEVVQMLEGDGLAERWAASHDHSHFYHANMSYRTITSTDGNNQTKHLFGSSGFEDEDDNQALDSFAMELSGPR
Protein: Phospholipid scramblase (Q9SI32)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein LURP-one-related 15
- Tubby-like F-box protein 10
- Tubby-like F-box protein 1
- Tubby-like F-box protein 11
Sequence:
MIYLSRRSLSSLLRSGFNLRGDLTAAAVSCSSLFSDADGGIKKLHSRAGNAVLWRNSQLCSSQGSFFGRGGQVSGSVFRCFCSGSDTSPPSLDRKFLAQLWVADKKKLKAMEKRYKKASKHRNYTENDGFDVHFETVEPTVEQPPVSQSMSGLLKPKTSDEAKIATLLARSNLLVTRDIEWANLVLGFEQENRYIVVDVCYPEAPVGSIREQSNLLARQLLRTRRPFVASITDALGNELFRVRRPFWWLTSSIYAEIDGEEIGVVHRRWHLWRRIYDLYLGNNQFAVVENPGFWNWTFTVKDADGEVLAQIDRDWRGFGFEIFTDAGQYVIRFGKADAAAKTGPATLVEELEVKRPLTLSERAVVLTLAISLDNDYFSRHGGWGIPFMAVGE
Protein: Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Q9FV81)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000269|PubMed:18441100}. Plastid, chloroplast {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000269|PubMed:18441100}.
Interaction partners:
- Aspartate--tRNA ligase, chloroplastic/mitochondrial
- Glutamyl-tRNA
- Outer envelope protein 64, chloroplastic
- Outer envelope protein 64, mitochondrial
- Probable amidase At4g34880
- Fatty acid amide hydrolase
- Amidase 1
- Amidase family protein
- Glutamine--tRNA ligase, cytoplasmic
- Glutamyl-tRNA
Sequence:
MSTTLLRTIQLNQFSLLGTSLLRRRRSNNFSVRSCGSQTTTTHEAKQSSPTRVAPKNHKSNQLDEILRDYEAVIGIETHVQLSTLTKAFCSCSNNYGSYPNTSICPVCMGLPGALPVLNSKVVEFGVRLGLALNCDLSLKSKFDRKQYFYPDLPKGYQISQFDIPIASGGYVDVDIPLEFGGGHRRFGITRVHMEEDAGKLLHSDTGDYSQVDLNRAGVPLLEIVSEPDMRSGIEAAEYACEMQRIARYLGVSNGNMQEGSLRCDVNISIRPIGQAEFGTKVEIKNLNAFSAISRAIDFEISRQALLYNQGKADQIVTETRLWEEGAQKTVTMRKKEGLADYRYFPEPDLPEVILTQEYVDSIRASLPELPEAKRRRYEAMGLGMQDVLFLANDVSVAEYFDAVIGKGAEVKLAANWIMSDIAAYLKNEKLSINDIKLTPQELAELIAAIKDGTISGKIGKEILFELLAKGGTVKGMIKAKDLVQITDPAEIEKMVIQVVSENPKQLEQYRSGKTKLQGYFAGQVMKMSKGKANPGLLNKILLEKLNAKD
Protein: RE26896p (Q8IGU7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSTLRPVSVCDTTPLQRFESQSSSGEEPSSPTASSIIAAASGPNHNNNNNVKLDLQLPTFVDSTRSQGSLYAVASNKKPPLRGPRQIFGRILTDLCLLSCVGLPMLGFSLWGEAVKRGFFCDDSSLRHPYRDSTMPSWILYLMCGALPLTVMLVVEFFRGQDKRVHSPFPKSTMCSGYHLCHLELPTWLVECYHRMGIFIFGLGVEQLSTNIAKYSIGRLRPHFYTLCQPVMKDGTTCSDPINAARYIEEFTCAAVDITSKQLKDMRLSFPSGHASFACYSMLYLVIYLHRRMQWKQLRMLCHLLQFLLLMFAWYTALTRVSDYKHHWSDVLAGSGIGLTYAVVVTSTMW
Protein: Solute carrier family 16 member 3 (J3QQV2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
Protein: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (EC 2.4.3.3) (GalNAc alpha-2,6-sialyltransferase II) (ST6GalNAc II) (ST6GalNAcII) (SThM) (Sialyltransferase 7B) (SIAT7-B) (Q9UJ37)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins. Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Elongation factor 1-alpha 2
- Alpha-2-HS-glycoprotein
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Mucin-1
- C1GALT1-specific chaperone 1
Sequence:
MGLPRGSFFWLLLLLTAACSGLLFALYFSAVQRYPGPAAGARDTTSFEAFFQSKASNSWTGKGQACRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALWRDLHKAGILQLYQR
Protein: RNA polymerase II-associated protein 1 (Q9BWH6)
Organism: Homo sapiens (Human)
Function: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- GPN-loop GTPase 1
- GPN-loop GTPase 2
- DNA-directed RNA polymerase II subunit RPB11-a
- Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
- RNA polymerase II-associated protein 3
- DNA-directed RNA polymerase II subunit GRINL1A
- RuvB-like 1
- Integrator complex subunit 3
- DNA-directed RNA polymerase II subunit RPB3
- RuvB-like 2
Sequence:
MLSRPKPGESEVDLLHFQSQFLAAGAAPAVQLVKKGNRGGGDANSDRPPLQDHRDVVMLDNLPDLPPALVPSPPKRARPSPGHCLPEDEDPEERLRRHDQHITAVLTKIIERDTSSVAVNLPVPSGVAFPAVFLRSRDTQGKSATSGKRSIFAQEIAARRIAEAKGPSVGEVVPNVGPPEGAVTCETPTPRNQGCQLPGSSHSFQGPNLVTGKGLRDQEAEQEAQTIHEENIARLQAMAPEEILQEQQRLLAQLDPSLVAFLRSHSHTQEQTGETASEEQRPGGPSANVTKEEPLMSAFASEPRKRDKLEPEAPALALPVTPQKEWLHMDTVELEKLHWTQDLPPVRRQQTQERMQARFSLQGELLAPDVDLPTHLGLHHHGEEAERAGYSLQELFHLTRSQVSQQRALALHVLAQVISRAQAGEFGDRLAGSVLSLLLDAGFLFLLRFSLDDRVDGVIATAIRALRALLVAPGDEELLDSTFSWYHGALTFPLMPSQEDKEDEDEDEECPAGKAKRKSPEEESRPPPDLARHDVIKGLLATSLLPRLRYVLEVTYPGPAVVLDILAVLIRLARHSLESATRVLECPRLIETIVREFLPTSWSPVGAGPTPSLYKVPCATAMKLLRVLASAGRNIAARLLSSFDLRSRLCRIIAEAPQELALPPEEAEMLSTEALRLWAVAASYGQGGYLYRELYPVLMRALQVVPRELSTHPPQPLSMQRIASLLTLLTQLTLAAGSTPAETISDSAEASLSATPSLVTWTQVSGLQPLVEPCLRQTLKLLSRPEMWRAVGPVPVACLLFLGAYYQAWSQQPSSCPEDWLQDMQRLSEELLLPLLSQPTLGSLWDSLRHCSLLCNPLSCVPALEAPPSLVSLGCSGGCPRLSLAGSASPFPFLTALLSLLNTLAQIHKGLCGQLAAILAAPGLQNYFLQCVAPGAAPHLTPFSAWALRHEYHLQYLALALAQKAAALQPLPATHAALYHGMALALLSRLLPGSEYLTHELLLSCVFRLEFLPERTSGGPEAADFSDQLSLGSSRVPRCGQGTLLAQACQDLPSIRNCYLTHCSPARASLLASQALHRGELQRVPTLLLPMPTEPLLPTDWPFLPLIRLYHRASDTPSGLSPTDTMGTAMRVLQWVLVLESWRPQALWAVPPAARLARLMCVFLVDSELFRESPVQHLVAALLAQLCQPQVLPNLNLDCRLPGLTSFPDLYANFLDHFEAVSFGDHLFGALVLLPLQRRFSVTLRLALFGEHVGALRALSLPLTQLPVSLECYTVPPEDNLALLQLYFRTLVTGALRPRWCPVLYAVAVAHVNSFIFSQDPQSSDEVKAARRSMLQKTWLLADEGLRQHLLHYKLPNSTLPEGFELYSQLPPLRQHYLQRLTSTVLQNGVSET
Protein: Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) (Q8CHW4)
Organism: Mus musculus (Mouse)
Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56287}.
Interaction partners:
- Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit gamma
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 2 subunit 3, X-linked
- Eukaryotic translation initiation factor 2 subunit 3, Y-linked
- E3 ubiquitin-protein ligase ARIH1
- RNA cytosine C
Sequence:
MAATAAVPGAAAGRASKRGGGGSGGGGTQGAEEEPPPPLQAVLVADSFNRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLQKSKWCHPTSPNVVRIITSELYRSLGDVLRDVDAKALVRSDFLLIYGDVISNINICRALEEHRLRRKLEKNVSVMTMVFKESSPSHPTRCHEDNVVMAVDSATNRVLHFQKTQGLRRFSFPLSLFQGSGDGVEIRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGILMNEEVLGNQIHLHVTTREYGARVSNLHMYSAVCADVIRRWVYPLTPEVNFTDSTTQSYTHSRHNIYRGPEVSLGHGSVLEENVLLGAGTVIGSNCSITNSVIGPNCHIGDNVVLDQAYLWQGVRVAAGAQIHQSLLCDRAEVKERVKLKPYCVLTSQVVVGPDITLPEGSVISLHPPDAEEDEDDGQFSDDSGADQEKEKVKLKGYNPAEVGLEGQGYLWKAEGVNSKEDEELRQSLWGLMIKTEEESETESEGSVDPEELDSRAGSPQLDDIRVFQNEVLGTLQRGREENISCENLVLEINSLKHAYNISLKEVMQVLTLVVLEFPLQQVDGLLDPNRYCALLLPLLKAWSPVLRNYIKRAADHLEALAAIEDFFLEHETLVTSMAKVLMAFYQLEILAEETILSWFSQRDTTDEGQQLRKNQQLQRFIQWLREAEEESSEDD
Protein: Signal transducer and activator of transcription (Q9QXJ2)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
Sequence:
MAQWEMLQNLDSLFLDQLHQVYSQSILPMDVRQHLATWIEDQNWREAALGSDDAKANMLYFSILDQLNQWDHYSSDSNHFLLQHNLRKFSRDIQTFPNGPTQLAEMIFNLLLEEQRILNQAQRAQEVQPPPAPEAVVESQQLEIENRIQGLHVDIEFLVRSIRQLKDEQDVFSFRYTVFSLKKTSSSDPHQSQQAQLVQATANKVDRMRKEVLDISKGLVGRLTTLVDLLLPKLDEWKVQQQKSCIGAPPPELQLEQLEQWLTAGAKFLFHLRQLLKQLKEMSHMLRYKGDMFGQGVDLQNAQVMELLQRLLQRSFVVETQPCMPQTLHRPLILKTGNKFTVRTRLLVRLQEGSESLKAEVSVDRNSDLPGFRKFNILTSNQKTLTPEEGQRQGLIWDFGFLTLVEQRAVGAGKGNKGPLAVTEELHVISFVVEYVYQGLKMKLQTDTLPVVIISNMNQLSIAWASILWFNMLSPNPKNQQFFCQAPKAPWSLLGPVLSWQFSSYVGRGLDSEQLGMLRTKLFGKSCKMEDALLSWVDFCKRESPPGKIPFWTWLDKILELVHDHLKDLWKDGRIMGFVSRNQERRLLKKMLSGTFLLRFSETSEGGITCSWVEHQDDDKVEIYSVQPYTKEVLQSLPLTEIIRHYQVLAEENIPENPLRFLYPRIPRDEAFGCYYQEKVNFEEQRKYLKHKLIVISNRQVDELQQPLELKQDSESLEVNAELLLAHDQELPLMMQTGLVLGTELKVDPILSTAPQVLLEPAPQVLLEPAPQVPLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVQLEPAPQVLLELAPQVLLEPAPQVLLELAPQVQLEPAHLLQQPSESDLPEDLQQISVEDLKKLSNPSTEYITTNENPMLAGESSGDETSIPYHSHFDADGLLGWTLDTF
Protein: ABC transporter A family member 3 (ABC transporter ABCA.3) (Q54BT5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- TM2 domain-containing protein DDB_G0278163
- Queuine tRNA-ribosyltransferase catalytic subunit 1
- UV radiation resistance-associated gene protein
- Myb-like protein I
- RNA cytidine acetyltransferase
- AMP deaminase
Sequence:
MGEFKFQLVTLLKKNSLLKGKSKIKFIGEILAPMIVIGILFGLLYLSAIIQPDFSPRYASGFTEVVGRLKKLLVATNGPLVPYQQTIVNNLRKQIKLAHPDYTNEYIDQCFEIFQDFESMQGYFLDPENYRGVMGGLWFDENDYRYNAPKVLKYSISVDADYTNDNNIQISPRSDSQIYLRHYFTQIQTAVDQAIFMAQNVEIPMVVTGQRFPNPYIHLWQTWTDGRNMILKETGGIFITAAIFVGLFTTITNMVMEKESKILEAMKIMGLHSLPYYVSIAISSCYTIIPSTIIVIVVLKGSQLIWTTQWYILTIILILFSISLILLAFILSKFFNRSKFAGLVCFLIVLIMAGIGIAVNHINVSTTVKLIFCLLSPVAISLANYSMSMKDLELVKIVNPDWSIIVSENQVIGMLILDVVLYAALVWYIDNIISGEFGQSKPFYFFLTKSYWCKKNANENDLVDLSKAIESPLYLRKKDLDYNNSQDFELNEIHSSKATIQIRKLRKEFKTGDGKRVAVDDLSIDMYQDRIHCFLGPNGSGKSTTIGMLTGLITCTRGSALINGLDINQNIDLIRKNIGVVLQQDIIWDNLTVLEHLIFYAQLKGYSNLKEAKTEAKKMGIEVGLELKLHNKAGTLSGGQKRKLCLGIAFIGPNSNILFLDEVSSGLDPLSRSEVQDFIISKKKGKTIILSTHYMDEADLLGDTISIIAHGKLKCNGSPLFLKNRFGVGYLLTITKKSTEFNKDSVMEITNKYIKQAHILSDAGTELSIRLPMESLPMFSQYFKHLEDCKNQLLIDSYGISISTLEEVFLKIGQETLKSTPNFNDPAVKEALSTKSSGVKVGQQLKGLLIKRICTTKKDFKSFMFSIVVPLIILALGLVMYKNMRTIETFNDVTTPLTFSIDDYGDNIYVPWSISGQNQAIDLRIKNSIGKSNHSKLLPADELEDYLTLNYEGNPGAFAFGKTIIEDIEMLSFKVYYNRDYLHALPIYINFVDNLMLSNLGGVGIQTTSRPFQHIKSKFELATEKINFSAIIFFIILTLAAFALVVASHAGNIAQERAARIKRLLYISGLKKYVYWLSNLIWDYVLTFIMVIFLAVVVVIIDSKFRNQFPLFICALVLFVTAIIPLSYLFSYCWSSHGKATGFIFGIHFGIGLLMTVTCFILRIWVIKDDNDILQTITDIIDLVFFFFSPFYCFSKVMVIISNFPGTTRLGESYIANYWGIKFGLPPVCFLALHTLVWTIWIMVLDYYPELRGKYRKGRNEKSSPPPPSDEDSDVSHERSKVLSFETSNDPIIMRDFFKLYKGKGKAKDNLAVYNTSLSIPKGQTFGLLGLNGAGKSTTLGCLSGEVIPSGGEIFVNGFNIQTQRLDALRSVGFCHQYNSLIGLLSAREQIRLYCRIKGIEESKIQETVEAFIKMMDLGSIGNSNVAGYSGGNKRKVALSVAIVGNPSVCFLDEVSAGVDPVVARFMWNVITELKKDKVIILTTHSMLECSAVCDRLTIMKSGKMMCLGSIQHIKDKFGSGYSIDVKFKKEYLLSGINLFQKELPNAKLVDHHDLSASFELPNSLDSPIQLSKIFSIIERNLKPILNDYSVGQTSIDHIFLKLTNLNQQKIKNQQKESIENHIIDINNNNNNNNNNSYLKNHKKTTSNNSILTNNSTTKNFGSSNFLDLESDNTYLNNLKYLEDDDFNIEMPPYQNSLKKSF
Protein: Flavin-dependent halogenase rdc2 (EC 1.14.14.-) (Hypothemycin biosynthesis cluster protein rdc2) (Non-heme halogenase rdc2) (B3FWT7)
Organism: Metacordyceps chlamydosporia (Nematophagous fungus) (Pochonia chlamydosporia)
Function: Flavin-dependent halogenase; part of the gene cluster that mediates the biosynthesis of radicicol, a resorcylic acid lactone (RAL) that irreversibly inhibits the HSP90 molecular chaperone, an important target for cancer chemotherapy. Within the cluster, rdc2 is involved in the chlorination of the resorcylic acid lactone (RAL) structure to convert monocillin I into radicicol. Also chlorinates monocillin II to produce 6-cholomonocillin II and monocilllin IV to produce 13-chloromonocillin IV. In contrast to most fungal halogenases, rdc2 has a broad substrate specificity and can accept a variety of macrolactones as the substrates to generate chlorinated derivatives, including dihydroresorcylide, zearalenone, curvularin, or even curcumin. Rdc2 is able to dichlorinate dihydroresorcylide and monocillin IV. Dihydroresorcylide is first chlorinated at position 11 to produce 11-chlorodihydroresorcylide which can be further chlorinated by rdc2 at possition 13. Mororeover, rdc2 can incorporate bromine into dihydroresorcylide to yield the corresponding mono- and di-brominated derivatives. Finally, rdc2 is also able to halogenate the isoquinolines 4-hydroxyisoquinoline and 6-hydroxyisoquinoline into 3-chloro-4-hydroxyisoquinoline and 5-chloro-6-hydroxyisoquinoline, respectively. The radicicol cluster encodes only two apparent post-PKS enzymes, a cytochrome P450 monooxygenase (rdc4) and a non-heme halogenase (rdc2) that could introduce the epoxide and the chlorine, respectively. If this cluster includes all the genes required for radicicol biosynthesis, the remaining structural features of radicicol are presumably generated by the PKSs rdc1 and rdc5. The C-2' ketone could arise if the R-PKS rdc5 and NR-PKS rdc1 each carry out four iterations, in contrast to the five iteration-three iteration split for the hypothemycin PKSs. The origin of the cis 5',6' double bond is not known. The radicicol R-PKS rdc5 ER domain may catalyze either double bond isomerization or reduction in the third iteration (Probable).
Interaction partners:
Sequence:
MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV
Protein: DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (Q4W5Z4)
Organism: Gallus gallus (Chicken)
Function: Required for genome-wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity. Also has weak auto-methylation activity on some Cys residue in absence of DNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y6K1}. Chromosome {ECO:0000250|UniProtKB:Q9Y6K1}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y6K1}. Note=Accumulates in the major satellite repeats at pericentric heterochromatin. {ECO:0000250|UniProtKB:O88508}.
Interaction partners:
- DNA
- Uncharacterized protein.
- Histone H4
- Adenosylhomocysteinase
- Methionine adenosyltransferase 2 subunit beta
- S-adenosylmethionine synthase
- AdoHcyase_NAD domain-containing protein
- Adenosylhomocysteinase like 2
- S-adenosylmethionine decarboxylase proenzyme
- tRNA
Sequence:
MVESSDTPKDTAAVPKCPPPCPEASPAEPLPNGDLEADGAQWKGTEEGGASPKSGRPEEDETESLADGETGRALENGRCTPKEGLDAPADEGELAPSDPQKKRGRRKLLEATEKSKEEKEENNFDSLKMEGSRGRLRGGLGWESSLRQRPMQRHTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAVMNVVEETPRAEPQKEEEASPPASQQPTDPASPNVATTPEPVVADAVDKNTSKSADDEPEYEDGRGLGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLLPLSSFSSAFHQATYNKQPMYRKAIYEVLQVASSRAGKIFPACPENDETDTSKVVEIQNKQMIEWALGGFQPSGPKGLEPPEEERNPYKEVYTEMWVEPEAAAYAPPPPAKKPRKSTTEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFIGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGVYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRNVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHEARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Protein: Auxin-responsive protein SAUR76 (Protein SMALL AUXIN UP RNA 76) (Q29PU2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the regulation of ethylene receptor signaling. Promotes cell expansion and plant growth (Probable). Involved in the regulation of cell elongation.
Subcellular location: Nucleus {ECO:0000269|PubMed:24312429}. Cytoplasm {ECO:0000269|PubMed:24312429}. Cell membrane {ECO:0000269|PubMed:24312429}; Peripheral membrane protein {ECO:0000305|PubMed:24312429}.
Interaction partners:
- Leucine-rich repeat
- Auxin-responsive protein SAUR36
- Auxin-responsive protein SAUR63
- Auxin-responsive protein SAUR41
- Protein SMALL AUXIN UP-REGULATED RNA 8
- Auxin-responsive protein SAUR19
- AT4G30480 protein
- AT4g00880 protein
Sequence:
MAKGGNKLMKLKSVLKKLNSFNTKPNQPPAQTNHSRSSAVSAFPSEDLQTVYVGRTRRTYHVSSDVVSHPLFQQLAAVDGGCGSEDGSISVSCEVVLFEHLLWMLENADADESRPESVYELVEFYAC
Protein: Thyrotropin receptor (Q6TCF9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Cell membrane {ECO:0000256|RuleBase:RU361222}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361222}.
Interaction partners:
Sequence:
MVLSMMLCFILGCSMANTEDTLAASQFCAFNGSTRSFVCLGNKVLEIPRRIPTNTTFVEIKLTQISVFRRAALSELHELKRIVVSENGALERIEALAFFNLTELEEITITKSKNLVMHKDAFWRLPKLRYLTISNTGLKILPDFSKINSAALEFLFDLQDNMHIERIPSNAFLGLTNATITELRLTKNGIREIDSHAFNGTKIGKLFLMGNQQLNHIHSYAFKGAEGPVVLDISRTAVHTLPESMLKTLKLLMAVSVYSLRKLPSLELFTELTQANLTYPSHCCAFKNFKKHKSVKNQMCNVTGAHEEPDFFNFFNDHCKDVIEVTCYPTPDAFNPCEDIMGFTFLRVLIWFISVLAIVGNTVVLLVLLTSRYKLTVPRFLMCHLAFADLCMGIYLLLIAAVDIHTQSRYYNYGIDWQTGAGCHVAGFFTVFSSELSVYTLTAITLERWHTITYAMQLERQMRLRHACLVMATGWLFSLLAALMPMFGVSSYSKTSICLPMDVETLLSQGYVVLLLLLNAAAFLVVCVCYTLIYLTVRNPAFVPANADMRIAKRMAVLIFTDFLCMAPISFFAISAAFKLPLITASHAKVLLVLFYPINSCSNPFLYAFFTKTFKRDFFILTSRFGCFKRRAHIYCTEISSGQNGAVVPSPKTSDGTLYSLVHIAQVH
Protein: MOB kinase activator 3C (Mob1 homolog 2C) (Mps one binder kinase activator-like 2C) (Q70IA8)
Organism: Homo sapiens (Human)
Function: May regulate the activity of kinases.
Interaction partners:
Sequence:
MALCLKQVFAKDKTFRPRKRFEPGTQRFELYKKAQASLKSGLDLRSVVRLPPGENIDDWIAVHVVDFFNRINLIYGTMAERCSETSCPVMAGGPRYEYRWQDERQYRRPAKLSAPRYMALLMDWIEGLINDEEVFPTRVGVPFPKNFQQVCTKILTRLFRVFVHVYIHHFDSILSMGAEAHVNTCYKHFYYFIREFSLVDQRELEPLREMTERICH
Protein: Mitochondrial import inner membrane translocase subunit TIM14 (DnaJ homolog subfamily C member 21) (P91454)
Organism: Caenorhabditis elegans
Function: Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit tim-16
- Mitochondrial import inner membrane translocase subunit TIM23
- Mitochondrial import inner membrane translocase subunit TIM50
- Probable mitochondrial import inner membrane translocase subunit tim-17B.1
- Probable mitochondrial import inner membrane translocase subunit tin-44
- Heat shock protein hsp-6
- Mitochondrial import receptor subunit TOM22 homolog
- GrpE protein homolog
- COX5B-domain-containing protein
- Mitochondrial import inner membrane translocase subunit Tim10
Sequence:
MTGGLIVAGLGLAAVGFGARYVLRNQALIKKGMEAIPVAGGAFSNYYRGGFDQKMSRAEAAKILGVAPSAKPAKIKEAHKKVMIVNHPDRGGSPYLAAKINEAKDLMESSKS
Protein: Zinc finger and SCAN domain-containing protein 12 (Zinc finger protein 305) (Zinc finger protein 96) (O43309)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
Interaction partners:
Sequence:
MASTWAIQAHMDQDEPLEVKIEEEKYTTRQDWDLRKNNTHSREVFRQYFRQFCYQETSGPREALSRLRELCHQWLRPETHTKEQILELLVLEQFLTILPEELQAWVQEQHPESGEEVVTVLEDLERELDEPGEQVSVHTGEQEMFLQETVRLRKEGEPSMSLQSMKAQPKYESPELESQQEQVLDVETGNEYGNLKQEVSEEMEPHGKTSSKFENDMSKSARCGETREPEEITEEPSACSREDKQPTCDENGVSLTENSDHTEHQRICPGEESYGCDDCGKAFSQHSHLIEHQRIHTGDRPYKCEECGKAFRGRTVLIRHKIIHTGEKPYKCNECGKAFGRWSALNQHQRLHTGEKHYHCNDCGKAFSQKAGLFHHIKIHTRDKPYQCTQCNKSFSRRSILTQHQGVHTGAKPYECNECGKAFVYNSSLVSHQEIHHKEKCYQCKECGKSFSQSGLIQHQRIHTGEKPYKCDVCEKAFIQRTSLTEHQRIHTGERPYKCDKCGKAFTQRSVLTEHQRIHTGERPYKCDECGNAFRGITSLIQHQRIHTGEKPYQCDECGKAFRQRSDLSKHQRIHNRRGTYVCKECGKSFRQNSALTQHQTIHKGEKSVSV
Protein: Uncharacterized ABC transporter ATP-binding protein YejF (P33916)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Inner membrane ABC transporter permease protein YejE
- Uncharacterized protein YejA
- Inner membrane ABC transporter permease protein YejB
- Oligopeptide transport system permease protein OppC
- Nickel transport system permease protein NikC
- Glutathione transport system permease protein GsiD
- Dipeptide transport system permease protein DppC
- Probable D,D-dipeptide transport system permease protein DdpC
- Putrescine export system permease protein SapC
- Glutathione transport system permease protein GsiC
Sequence:
MTQTLLAIENLSVGFRHQQTVRTVVNDVSLQIEAGETLALVGESGSGKSVTALSILRLLPSPPVEYLSGDIRFHGESLLHASDQTLRGVRGNKIAMIFQEPMVSLNPLHTLEKQLYEVLSLHRGMRREAARGEILNCLDRVGIRQAAKRLTDYPHQLSGGERQRVMIAMALLTRPELLIADEPTTALDVSVQAQILQLLRELQGELNMGMLFITHNLSIVRKLAHRVAVMQNGRCVEQNYAATLFASPTHPYTQKLLNSEPSGDPVPLPEPASTLLDVEQLQVAFPIRKGILKRIVDHNVVVKNISFTLRAGETLGLVGESGSGKSTTGLALLRLINSQGSIIFDGQPLQNLNRRQLLPIRHRIQVVFQDPNSSLNPRLNVLQIIEEGLRVHQPTLSAAQREQQVIAVMHEVGLDPETRHRYPAEFSGGQRQRIAIARALILKPSLIILDEPTSSLDKTVQAQILTLLKSLQQKHQLAYLFISHDLHVVRALCHQVIILRQGEVVEQGPCARVFATPQQEYTRQLLALS