wanglab/gogpt-training-data huggingface dataset:
Protein: Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5) (Q61762)
Organism: Mus musculus (Mouse)
Function: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11349004, ECO:0000269|PubMed:8226976}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Voltage-gated potassium channel subunit beta-2
- Voltage-gated potassium channel subunit beta-1
- Ubiquitin-like protein FUBI
- Sodium channel protein type 5 subunit alpha
- A-type potassium channel modulatory protein KCNIP2
- Voltage-gated potassium channel subunit beta-3
- Potassium voltage-gated channel subfamily A member 4
- Disks large homolog 4
- Disks large homolog 1
- Calcium-activated potassium channel subunit alpha-1
Sequence:
MEISLVPMENGSAMTLRGGGEAGASCVQSPRGECGCPPTAGLNNQSKETSPRRRATHEDAGQGGRPLPPMPQELPQPRRPSAEDEEGEGDPGLGTVEEDQAPQDSGSLHHQRVLINISGLRFETQLGTLAQFPNTLLGDPVKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGANGSGSGVLSSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIFPYFITLGTELAEQQPGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGSHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGIQRRESGLDTGGQRKVSCSKASFCKTGGPLESTDSIRRGSCPLEKCHLKAKSNVDLRRSLYALCLDTSRETDL
Protein: Putative mannan endo-1,6-alpha-mannosidase C970.02 (EC 3.2.1.101) (Endo-alpha-1->6-D-mannanase C970.02) (O74556)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Meiotically up-regulated gene 191 protein
- Autophagy-related protein 17
- TBC domain-containing protein C23D3.03c
- Autophagy protein 13
Sequence:
MSLTIFISLATILFSFAEAISVDLNDTSSVDLATSLVADGLLNYYAGQHKGGTIGMFLPPAYWWEAGAAWNGLLNRYIATGNSTYNELVKTSMLYQSGEDSDYMPSNYTTSEGNDDQAFWGLTVISAAEANFSNPAADEPQWLELAQAVFNQQVTRWDTDHCNGGLRWQITEFNSGYNYKNTVSNGAFFQLAARLARFTDNDTYAEWANVAYDWSQRIGFIQEDYTVFDGSSIKDNCSSIEITQWTYNIGLYMAGAAYMYNYTNSTVWKTRVEGFANKTAKTFFFKDIMFEPVCEIALSCNYDQTSFKGFLTRFMVYTAQMAPFTAPLLEPLLISTAKAAAGACCGGYDGVTCGVQWWWNNDTWDGLYGLGEQMSALEAIQAPLLLKSLQVFKASNGGSSTGDPNAGLYTAPVSFANKNFENLRKHWMLLGFFLLVPTLVLY
Protein: Glutaredoxin 5 (D4ADD7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- BolA-like protein 1
- Iron-sulfur cluster assembly 1 homolog, mitochondrial
- BolA-like protein 2
- BolA-like protein 3
- Iron-sulfur cluster assembly 2 homolog, mitochondrial
- Iron-sulfur clusters transporter ABCB7, mitochondrial
- Iron-sulfur cluster assembly enzyme ISCU
- Glutaredoxin-3
- Mitochondrial glycine transporter
- Iron-sulfur cluster co-chaperone protein HscB
Sequence:
MRLPGKAHRYGVSDMIGGIEPVLSNHETHPRAYPMRTSSGPAGHQGLCKPSGGRRSGDQRAGMSASLSRAAAALLRWGRGAGGGVLPRAGVRAASSGGQAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLEDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIRSALIDEKDQDSK
Protein: Virion infectivity factor (Vif) (SOR protein) [Cleaved into: p17; p7] (Q77YG0)
Organism: Human immunodeficiency virus type 1 (HIV-1)
Subcellular location: Host cell membrane {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|HAMAP-Rule:MF_04081}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|HAMAP-Rule:MF_04081}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|HAMAP-Rule:MF_04081}. Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04081}. Virion {ECO:0000256|ARBA:ARBA00004328, ECO:0000256|HAMAP-Rule:MF_04081}. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion. {ECO:0000256|HAMAP-Rule:MF_04081}.
Interaction partners:
Sequence:
MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSGKARGWFYRHHYESPHPRISSEVHIPLGDARLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSPRCEYQAGHNKVGSLQYLALAALITPKKIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH
Protein: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (F2Z4B7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDRLTQSLDSDKPKEPVKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQVTEPKVPQKLPAGRHTSKHGTLRGPSSSSNRTTKPSHANYSLDDITAQLEQASLSMDEAAQQSLVEDPKPLVTNQHRRTASAGTVSDAEARSISNSSRSSITSAASSMDSLDIDKVTRPQELDLTTHQGQPITEHAISLSCPSKQAKHHSDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETISELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDCCLALKHPQIQKKSQYIKYLCCDDARTLHQWVNGIRIAKYGKQLYTNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTLPTGHIRSQSTVSSIFSEAWKRGTQLEESSK
Protein: Cyclin K, isoform A (Cyclin K, isoform B) (Cyclin K, isoform C) (LD21709p) (Q961D1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cyclin-dependent kinase 9
- Cyclin-dependent kinase 12
- DLim1
- RE70879p
- Trivet, isoform I
- FI22161p1
- AT27166p
- Cyclin-H
- Transcription elongation factor SPT5
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MPCWYYDKKELRETPSILDGISFETERRYRKEGARFIMECGTKMGLGHNTMATGVVYFHRFYMFHSFRSFPRYVTACCCLFFAGKVEETPKKCRDIIKTARGILTDNYFYSFGDDPKEEVMTLERILLQTIKFDLQVEHPYTFLLKYAKCFKGDQQKLQKMVQMAWNFVNDSLSTVVCLQWEPEIIAVALIHLASKLSKFTVQDWEGRQPQQQRWWDMFVSDVTMEILEDICHQVLDLYQSTQKEALQPTSPPQKPPSRADSPKSGKLTNSTGIGPLSVPQQPPPPVCGNGGVLEVSNIQSIKSLASGVPIIGPSDSQNLLQGPTPPGQPSGYHIYHAPPPPPPPVVPMPPYPSSGWGVQQTVVGHYSGSAAPPPPMPPSLPPGASGYYNAGGRPSQQRY
Protein: Protein NRT1/ PTR FAMILY 5.1 (AtNPF5.1) (Q8VZR7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MEAAKVYTQDGTVDLQGRPVLASKTGRWRACSFLLGYEAFERMAFYGIASNLVNYLTKRLHEDTISSVRNVNNWSGAVWITPIAGAYIADSYIGRFWTFTASSLIYVLGMILLTMAVTVKSLRPTCENGVCNKASSLQVTFFYISLYTIAIGAGGTKPNISTFGADQFDSYSIEEKKQKVSFFNWWMFSSFLGALFATLGLVYIQENLGWGLGYGIPTVGLLVSLVVFYIGTPFYRHKVIKTDNLAKDLVQVPIAAFKNRKLQCPDDHLELYELDSHYYKSNGKHQVHHTPVFRFLDKAAIKTSSRVPCTVTKVEVAKRVLGLIFIWLVTLIPSTLWAQVNTLFVKQGTTLDRKIGSNFQIPAASLGSFVTLSMLLSVPMYDQSFVPFMRKKTGNPRGITLLQRLGVGFAIQIVAIAIASAVEVKRMRVIKEFHITSPTQVVPMSIFWLLPQYSLLGIGDVFNAIGLLEFFYDQSPEEMQSLGTTFFTSGIGLGNFLNSFLVTMIDKITSKGGGKSWIGNNLNDSRLDYYYGFLVVISIVNMGLFVWAASKYVYKSDDDTKEFSGGGCVQMEAKALDTSPLSI
Protein: thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) (Q9VUM4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Peroxiredoxin 2
- Sulfiredoxin
- Peroxiredoxin-5
- AT22380p
- Thioredoxin-2
- Thioredoxin-1
- Proteasome subunit beta
- Thioredoxin-T
Sequence:
MRMLNINQVAPNFTTNAVVSGGYRNFALTDLRGRYVLLVFYPADFSYVCPTELQAFSDRAPEFRNVGCEVLACSTDSHFVHCAWMNTPRKNGGLGELDIPLLADKNMKIARDYGVLDEDTGLALRALFIIDREGRIRQITVNDMGVGRSVDEALRLVQAFQFSDEFGEVCPVNWRPGAKTMKADATGKEEYFKHAI
Protein: Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML) (Q5VTD9)
Organism: Homo sapiens (Human)
Function: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:16688220}.
Interaction partners:
- Lysine-specific histone demethylase 1A FAD-dependent demethylase 1A)
- REST corepressor 1
- Erythroid transcription factor
- T-cell acute lymphocytic leukemia protein 1
- Histone deacetylase 1
- Rhombotin-2
- Histone deacetylase 2
- Endothelial transcription factor GATA-2
- Integrin alpha-IIb
- Multiple epidermal growth factor-like domains protein 8
Sequence:
MPRSFLVKSKKAHTYHQPRVQEDEPLWPPALTPVPRDQAPSNSPVLSTLFPNQCLDWTNLKREPELEQDQNLARMAPAPEGPIVLSRPQDGDSPLSDSPPFYKPSFSWDTLATTYGHSYRQAPSTMQSAFLEHSVSLYGSPLVPSTEPALDFSLRYSPGMDAYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDICGKTFGHAVSLEQHTHVHSQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK
Protein: Quick-to-court, isoform L (M9PCM5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MANGKPRNLSLQLNGGSDISSSGTSSSSSNNKESSPRTTRTPRTPQTPQTPQTPASGVAASVAETPHSCIRQGNCVKANQVKLSTLHESKISPRTPPVTPDSPSTYLDDDIDSMYSFATTTSGRSTMSCEHPYVARNGTTFSGRKMKYVVHCSNYAGQVGPDYLTPTQRAQRQIRRLKELLCIARQDLEQKDTELLRLTREVVELRLFKASLSSPEERSASSDAVTVREAELKTSQDVSPIVDMVDEGNAKGSPRHLSRQQQQQANHSLQAMQMSAEMQSSYADSGHFEDLTMSSVHSKDSQTQSEACGTATPDGEADVGCGAGGDSASNLENYELQRQELISMYEHRIEELIRSQDSATSDLKRSHNDKVEALLQKLAECNTRYSDMVPDYEQAKQRIRELEKQLEDLQRKLIEHEEKQNKMYLHMYQQGQEAERISRADQALDLAQRQPESKVSINELLHQLQSTQDELENIRTIYRRLLEAQKNRTHVDPEVTLQFLKSAIFYFLTDKENSQGHLQAIESILEFTDAEKQKISAANRTPK
Protein: AT-hook motif nuclear-localized protein 16 (Protein TRANSPOSABLE ELEMENT SILENCING VIA AT-HOOK) (Protein TEK) (Q9SJG4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs). Encodes a nuclear matrix protein that acts in the maintenance of genomic integrity by silencing TEs and repeat-containing genes through epigenetic machinery. Acts as a chromatin remodeling factor that modifies the architecture of FLC and FWA chromatin by modulating both H3 acetylation and methylation leading to the regulation of FLC and FWA expression. Negatively regulates floral repressors including MAF4 and MAF5. Plays a transcription activation role in anther development. Regulates the expression of arabinogalactan proteins (AGPs) involved in the formation of the nexine layer of the pollen wall. Binds AGP6, AGP11, AGP23 and AGP40 promoters.
Subcellular location: Nucleus {ECO:0000269|PubMed:24804694}.
Interaction partners:
- Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- WD-40 repeat-containing protein MSI5
- 26S proteasome regulatory subunit RPN13
- Proteasome subunit beta type-6
- Proteasome subunit beta type-4
- 26S proteasome non-ATPase regulatory subunit 12 homolog A
- 26S proteasome non-ATPase regulatory subunit 12 homolog B
Sequence:
MAGGTALTPTSVGSKSVPMRNHEATERGNTNNNLRALPKAVQPVSSIEGEMAKRPRGRPAGSKNKPKPPIIVTHDSPNSLRANAVEISSGCDICETLSDFARRKQRGLCILSANGCVTNVTLRQPASSGAIVTLHGRYEILSLLGSILPPPAPLGITGLTIYLAGPQGQVVGGGVVGGLIASGPVVLMAASFMNAVFDRLPMDDDEAASMQNQQYYQNGRSRPLDDIHGLPQNLLTNGNSASDIYSWGPAQRVMSKP
Protein: E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) (Q9NQ86)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28087737}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q80WG7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q80WG7}. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250|UniProtKB:Q80WG7}.
Interaction partners:
- Centromere protein H
- Trimethyllysine dioxygenase, mitochondrial
- T-cell receptor-associated transmembrane adapter 1
- Gamma-butyrobetaine dioxygenase
Sequence:
MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKELLLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
Protein: Response regulator GacA (Global activator) (Q51373)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.
Interaction partners:
- histidine kinase
- histidine kinase
- Sensory/regulatory protein RpfC
- histidine kinase
- cAMP-activated global transcriptional regulator Vfr
- HTH-type quorum-sensing regulator RhlR
- RNA polymerase sigma factor RpoS
- Transcriptional activator protein LasR
- UvrABC system protein C
- Translational regulator CsrA
Sequence:
MIKVLVVDDHDLVRTGITRMLADIEGLQVVGQADCGEDCLKLARELKPDVVLMDVKMPGIGGLEATRKLLRSQPDIKVVVVTVCEEDPFPTRLMQAGAAGYMTKGAGLEEMVQAIRQVFAGQRYISPQIAQQLALKSFQPQQHDSPFDSLSEREIQIALMIANCHKVQSISDKLCLSPKTVNTYRYRIFEKLSITSDVELALLAVRHGMVDAAS
Protein: Protein ELYS homolog (Q9VWE6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the nuclear pore complex. Binds to transcriptionally active chromatin including regulatory regions.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:28366641, ECO:0000269|PubMed:28472469}. Chromosome {ECO:0000269|PubMed:28366641, ECO:0000269|PubMed:31784359}. Note=Interacts with chromatin. {ECO:0000269|PubMed:28366641, ECO:0000269|PubMed:31784359}.
Interaction partners:
- Nuclear pore complex protein Nup107
- Nuclear pore complex protein Nup133
- Nucleoporin Nup37
- Nuclear pore complex protein Nup160 homolog
- Nucleoporin seh1
- Nucleoporin 43kD
- Nuclear pore complex protein Nup98-Nup96
- Protein SEC13 homolog
- Nuclear pore complex protein Nup154
- Nuclear pore complex protein Nup75
Sequence:
MEWHEVELDGSRTIAFPERIVPGFGREPSAHLDAAEYLGGIIRDGQWGWVTWRYGSDATLLVCSMSTGDYLSWHCFWSESDDLGPRKSIRCVEELFPGEHERPAMLAICLESWNSGDQRPIDCPLSTQVLIYAIRNSQVLRRFDLHGITCSALTFLDKRIYGLTRLRRFKGCLAVATEEGTVLLVDLNSDSLQASTQRRSLCSPSSKDEPSDGNLYFVSSEESKRQLSSKLTHCRSKGAHLAVRMDVASIGISCLMGISMAPGYAAGLEDGRILIYDLINFDVTTDLNSPVKRKGVNRAVKRMCLIMPPDDPKPCFYICALYQNIDVLQMMLHSVCYRGSYRDRETHTIRFKDYRSRTVRNRQILDGGICSVIGCATASTFSFAGDNGTLLIVISWHSSADKKNKLVLFDINQWYKDEMPTSVHKNEVPNYMSGYILSGLQTGLALDLRSTTILHFVSLQRYDEHFYPNSLTFDCSLLTPTGKRYYAQDGVQHRFLNALRCDRATLFLRPQIYHEDIVRLRLLPQFCELNPNATFSKIAMYELILSVALEHNCGALLNDCARSWMDGSFLCNMIDNTQLSLSTLTNWILKRAGQIKTRCSELCHGIFDYGGYPLDQRERREFQVLSGQLRELVRLQSYIVEQGRRRLTSSILDDCRANERALKTVLEYQRVLLWFIDHGLLPEGQHMDNLVPGEQAFVRLQHEYSEKRAQGKILYIDSLGKRASFPEPYPPDSLHAYIHLMLSPDIELCHKHALILYLLMDLNQQLVGRFQIAFQLDKDLATSLRCFWYLDHGDYERGVEELYKEPAPAKNLKSWQMRLLIDKLLAEGAVKAAKKVVSRPPGPLSSALHMKVLLANENITEAFQIARLDDDEDGQPLLERFFRHCIEIRRFKVLAELYLREPEERLLYSLLRQCRSRQTDCVQLIMLLQKSKFIEAVSFMDEVAAERERDESSNTILPAYSATMGPVTQNIAGTYLRIRDTLEPYQKTGPLEPFSCQLVKQNASGQLGGIFQSSAVSAHWATQCESPPKMTPVSIQSKIGYTNVPFLRHAQYGHSELPLPRRIVKPVPHQVVEKRQRELEDQRTNLQDQRQLGTERPNKRPCLMVERMVEDVKDYVRSIREKSSNQMEQEEVKQNEATNLLQPPNFLQARQSTTIRQSSSSPQPIPPILKGSGAVDAVKRAPPVATFTALAGPKRFRFVPPIPLRTDKSDKSTEMGSEGAAEGEEETDEIIVEIESRSEPRSACSYESDEEDEFLSPLVSANVSLVDPVPSRNSPHYFAPPAGPQPRNSLLHGGNGSGSKIGTATGSESSSGFGSFSTVQPAQTSSHSQFVPTVCSSKMGETQSQVFSSGSCGIKISERTTICGEMESTDLGAELTAAPSAQWSLPSARPAIQGHHQMMDTTLGMSTYDVASLEQQDTQDVENEEELKLGDTKSLEEQQNPQDEQKPEQEQDQDEDQAQEPLATGGQLAFLSNSEGTAQEPLSSPIYSLSSEDSNVSSAGIRNPMLPTLHTDDPMYSIVVESPGSITTSRSVTHTPTSFLPSDTNVSQTSSPQAPHGEDGDGTPISLYRANSLETVDDLDTTKGSLEEEEEYDDDDCVIALDGTEVRGYVARPQQSAASSSAELFAFKDECQEEAAGVPSPFLSLGATVNSDSDVADTIVLDSDEETAKEKDTQPEQRKDWPMEEETPSNESVATVEFSEQKQPRADMDIGMEVDAVPDVLEVLEVPEMEPLPVLSDVDIEMAVDEVPNVLEVLEVPELEPLPAGQATQSSGLGEIPEEDVDAEAEEQVVVKVEHVADEQPKEGDKTESKEASEEETQHNPEPLLPEEEDSRHSLKLIFSGDEDEEEQDVPTRAIHTLRPRRSFTEHQDSPRTLRPRRVSQEHRDSPTPVAGRTMSLRSTDAPTLSPASNPPVSTPKRRGLQHKYLLEVIDEHSPSDLSLPRTRSRTRLSVDSEATSSRPGTPTMTKARGKRATSQAPPTASPSVRRSLRGHSEPPAALSAQLVRKPKTARAGVRSRKTSSGVQSPVAVSPTPIDAPIDVPDSTAPEEEQPRLRRTARRRISELSDQSANGTGDLRSEASSSRTGSKSNSAASTQNRELRPRLRRTSKSEH
Protein: Formate hydrogenlyase transcriptional activator FhlA (P19323)
Organism: Escherichia coli (strain K12)
Function: Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. Also activates expression of hyf operon (encodes the silent hydrogenase-4 gene cluster).
Interaction partners:
- Formate dehydrogenase H
- Formate hydrogenlyase subunit 5
- Formate hydrogenlyase subunit 2
- Formate hydrogenlyase regulatory protein HycA
- Hydrogenase 3 maturation protease
- RNA polymerase sigma-54 factor
- Carbamoyl dehydratase HypE
- Hydrogenase-1 large chain
- Hydrogenase-2 large chain
- Formate channel FocA
Sequence:
MSYTPMSDLGQQGLFDITRTLLQQPDLASLCEALSQLVKRSALADNAAIVLWQAQTQRASYYASREKDTPIKYEDETVLAHGPVRSILSRPDTLHCSYEEFCETWPQLDAGGLYPKFGHYCLMPLAAEGHIFGGCEFIRYDDRPWSEKEFNRLQTFTQIVSVVTEQIQSRVVNNVDYELLCRERDNFRILVAITNAVLSRLDMDELVSEVAKEIHYYFDIDDISIVLRSHRKNKLNIYSTHYLDKQHPAHEQSEVDEAGTLTERVFKSKEMLLINLHERDDLAPYERMLFDTWGNQIQTLCLLPLMSGDTMLGVLKLAQCEEKVFTTTNLNLLRQIAERVAIAVDNALAYQEIHRLKERLVDENLALTEQLNNVDSEFGEIIGRSEAMYSVLKQVEMVAQSDSTVLILGETGTGKELIARAIHNLSGRNNRRMVKMNCAAMPAGLLESDLFGHERGAFTGASAQRIGRFELADKSSLFLDEVGDMPLELQPKLLRVLQEQEFERLGSNKIIQTDVRLIAATNRDLKKMVADREFRSDLYYRLNVFPIHLPPLRERPEDIPLLAKAFTFKIARRLGRNIDSIPAETLRTLSNMEWPGNVRELENVIERAVLLTRGNVLQLSLPDIVLPEPETPPAATVVALEGEDEYQLIVRVLKETNGVVAGPKGAAQRLGLKRTTLLSRMKRLGIDKSALI
Protein: Smooth, isoform AA (A0A0B4K8A2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEILPIKEIGNGRSPLLQEPLYGKSLFSIPENVVMLESQPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN
Protein: MICOS complex subunit MIC60 (Mitofilin) (Q5A044)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- MICOS complex subunit MIC10
- SAM complex subunit
- Sam51p
- MICOS complex subunit
- MICOS complex subunit
- NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial intermembrane space import and assembly protein 40
- Translocase of outer membrane 40 kDa subunit
Sequence:
MIRITSRSVKGAAGIRSVSSSTVRLNIAPKVVSPPVPPPVKPQGSEIPPPPPPPPPPPKAKRFSLFGFLFKTTLLATVVYGGTLYAATKNDKVMDFVIDKQLPFHEELIDLIENGSTEDLQEAWEQLKNKFTDVKLPTKDDIDELTQKLEHRGEDIIKETKKKIASTHIGHKSGTDLTPTEQLQRGVEIESVKKDVAHLPLIELNSDLGKSVDETVKQTITSFNNFIQSIDASSLATKDDKLITSINTSVNQLASRLNSLTKDFDNELQNKLKVSQTELFSSFTKKELELTENLLHQFSTEKQQLEAKLNQKLSQEIQAARAAISQAASNAVAMVRIEQTKNFEKLVSEKLNEERNGRLANLEKLNDRIVELEKFAEGFETQIVSNHKKAIIHQAVSKLKSLLLAPAAGDKPQPIKPYIDELTKIATDDEVLALAIKDLSPLITNESTHSILTNAQLLSRWEQLAPELRSASLLPPNAGLLGHLASIVFSKLLLPVKGVKEDGKDIESVIGRVESSLARGELDIAVEEAANLKGWSRKLANDWVVEGRKRLEIEFLLGLIESESKII
Protein: Rubrerythrin diiron-binding domain-containing protein (Q729F3)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Hydrogenase, putative
- Hydrogenase, iron-sulfur cluster-binding subunit, putative
- Hydrogenase, putative
- Heterodisulfide reductase, C subunit
- Heterodisulfide reductase, A subunit
- Heterodisulfide reductase, B subunit
Sequence:
MAEFFNAADVTAAAIRIEQRGQDVYRQAVAMTTNPEVRALFEHLAAEEAKHEATFRAMADRVGPVELPAWSIAAEYVEYLHALLDSHALFTQSGTLTSLKGAADDHATALQMAIQFEKDTLLFFTEMRNLVPASEKAAVDACIDEERAHLRALTAMLVQAKRS
Protein: Battenin (A0A8I6ALZ9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Lysosome membrane {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361113}.
Interaction partners:
Sequence:
MGSSESSWRRLEDSEREETDSEPQTPPLDNLSVLWKNAVGFWILGLCNNFSYVVMLSAAHDILKQEQASGNQSHAVLLADILPTLVIKLLAPLGLHLLPYSPRVLVSGVCSAGSFVLVAFSQSVGLSLCGVVLASISSGLGEVTFLSLTAFYPSAVISWWSSGTGGAGLLGSLSYLGLTQAGLSPQHTLLSMLGIPVLMLASYFLLLTSPEPLDPGGQDEAETAARQPLIGTETPESRPGTSWDLSLQERWTVFKGLLRYIIPLVLVYFAEYFINQGLFELLFFRNTSLSHAQQYRWYQMLYQAGVFASRSSLQCCRIRFTWILALLQCLNLAFLLADVCLTFLPSIYLIFIVILYEGLLGGAAYVNTFHNIALETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCHLP