wanglab/gogpt-training-data huggingface dataset:
Protein: Microfibrillar-associated protein 1B (Spliceosome B complex protein MFAP1B) (C0HKD9)
Organism: Mus musculus (Mouse)
Function: Involved in pre-mRNA splicing as a component of the spliceosome.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P55081}.
Interaction partners:
Sequence:
MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRLEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKREREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT
Protein: GRAM domain containing 1B (A0A1B0GUD6)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
Sequence:
MPAANMMENRPLPALQVPEPQGAPEGSPVWSSSSTPTLRRRRFKMRRMKNVQEQSLEAGLARDLPAVLAPGKEFLQLPSIEITPSSDEDTPWSNCSTPSASPRRKRFLLRKWLRVRERKECSESSSQQSSQQSSHDDDSSRFLSPRAREESTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH
Protein: Large ribosomal subunit protein bL33c (50S ribosomal protein L33, chloroplastic) (P56796)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Large ribosomal subunit protein bL20c
- Large ribosomal subunit protein bL36c
- Large ribosomal subunit protein uL14c
- Large ribosomal subunit protein bL32c
- Small ribosomal subunit protein bS16cz
- Small ribosomal subunit protein bS18c
- Small ribosomal subunit protein uS8c
- Large ribosomal subunit protein uL16c
- Large ribosomal subunit protein uL2cz/uL2cy
- Small ribosomal subunit protein uS14c
Sequence:
MAKGKDVRVTIILECTSCVRNDIKKEAAGISRYITQKNRHNTPSRLELRKFCPYCYKHTIHGEIKK
Protein: AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) (Q9JKC8)
Organism: Mus musculus (Mouse)
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular location: Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Interaction partners:
- AP-3 complex subunit delta-1
- AP-3 complex subunit beta-1
- AP-3 complex subunit beta-2
- AP-3 complex subunit sigma-2
- AP-3 complex subunit sigma-1
- AP-3 complex subunit mu-2
- AP-2 complex subunit alpha-1
- AP-1 complex subunit gamma-1
- AP-4 complex subunit epsilon-1
- AP-1 complex subunit gamma-like 2
Sequence:
MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLAWDVGKITPQKLPSLKGLVNLQSGAPKPEENPNLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT
Protein: Carnitine O-palmitoyltransferase 1, liver isoform isoform X2 (Carnitine palmitoyltransferase 1Ab (liver)) (K7DY29)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Carnitine O-palmitoyltransferase 2, mitochondrial
- Acetyl-CoA carboxylase beta.
- Acyl-CoA synthetase long chain family member 2.
- long-chain-fatty-acid--CoA ligase
- Long-chain-fatty-acid--CoA ligase ACSBG1
- Acyl-CoA synthetase long chain family member 4a.
- Long-chain-fatty-acid--CoA ligase
- Enoyl-CoA delta isomerase 2.
- Enoyl-CoA delta isomerase 1
- Family with sequence similarity 171 member A2b
Sequence:
MAEAHQAVAFQFTVTPDGIDLHLCHEALRQIYLSGIHSWKKRFIRFKNGVMTGVYPGSPSGLVVVLVGYMSSTKYAKIDPSLGILTKLSTHLPVSKYITEDGQRIVGGVLVGTGLWIAVTFVMRNALKYLLSWHGWMFNQHGTLSLKTKIWLVLVKLFSGPKPMLYSFQSSLPRLPVPPVKDTVRRYLESARPLMDDEQYKRMEGLAKDFEKNLGPKLQWYLKLKSWWTSNYVSDWWEEYIYLRGRSPIMVNSNYYAMDFLYVNPTSLQAARAGNSIHAMMMYRRKLDRAQIKPLMVLNTIPMCSSQYERMFNTSRVPGVETDVLQHVNESKHIAVYHKGRFYKVWMFYDGRLLLPREIEQQMERILADKSEPQPGEEFLAALTAGDRVPWAKARSQFFIRGKNKQSLDAVEKAAFFVTLDDSEQRYEPDNPIQSLDSYGKSLLHGKCYDRWFDKSLNLIVFKNGTMGLNAEHSWADAPIVGHLWEQVLSSDPVRLGYTEEGHCKGNPHPNMPGPQRLQWDIPEECQTVISSSLKVANTLADDVDMHIFPFNDFGKGLIKKCKTSPDGFIQLALQLAHFRDKGKFCLTYEASMTRLFREGRTETVRSCTNETCAFVHAMMDEKATREERLKLLKAATEKHQNLYKLAMTGKGIDRHLFCLYLVSKYLGEDSPFLKEVLSEPWRLSTSQTPLQQMELFDLKKHPEYVTSGGGFGPVADDGYGVSYIILGEDLINFHISSKHSSHETDSHRFGSNIKQAMLDILDLFQLDIKPNKK
Protein: Uncharacterized protein YHR097C (P38809)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MNQTGRTIGGPQNGVNTVINPFRVSPSEDRVSSRDETPRNYNNPFLNEDDTRRAHNSSVSNSRQERLPSYEEAAGTPKQQAPYPKEKKRSSGSNSHQHNHHHHRRTSHGHRDKDKQKSKSRTKVKPPKNVDTIDKMDVTGLFGGSFHHDGPFDACTPQRNKNNKVAPVLAFPADGPNNTVGGRTSKKSTLDEVFGRETVDDDSETLNQLQDRAYLFNKANSSTTTLDAIKPNSKNITQFDSKMKTELVHGPITMGLGSTTFLDGAPASSAAIEQDVINHAQESRRKNSIARKKSLPSRRHLQVNNNNLKLVKTHSGHLEQKDVDDNRTSVPVTATQGSGHEDVVKKENTGNKLLRRVKSLKTSKKH
Protein: Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (A7E2K4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- FAU ubiquitin-like and ribosomal protein S30 fusion a ubiquitously expressed
- Large ribosomal subunit protein P1
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein uS2
- 40S ribosomal protein S15
- Large ribosomal subunit protein eL19
- Ribosomal protein L3
- Small ribosomal subunit protein eS19
Sequence:
MRYVAAYLLAALGGKDSPSTGDIKKILESVGIEADDVRMSKVVAELNGKNVEEVIAQGFSKLASVPSGGAVAVSSAAAPSSGGSAAAPAAEEKKEEKKEESEESDDDMGFGLFD
Protein: Protein Wnt-3a (Q2LMP1)
Organism: Gallus gallus (Chicken)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity).
Subcellular location: [Isoform 1]: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:17488271}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17488271}.
Interaction partners:
- Low-density lipoprotein receptor-related protein
- Porcupine O-acyltransferase.
- Wnt inhibitory factor 1
- Frizzled-4
- Frizzled-2
- Frizzled-1
- Notum, palmitoleoyl-protein carboxylesterase.
- Axin-1
- Frizzled-7
- Secreted frizzled-related protein 2
Sequence:
MASFGYFLFLCGLSQALSSYPIWWSLAIGHQYSSLGTQPILCGSIPGLVPKQLRFCRNYVEIMPSVAEGVKIGIQECQHQFRGRRWNCTTVNDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSATICGCDTRHKGSPGEGWKWGGCSEDVEFGSMVSREFADARENRPDARSAMNRHNNEAGRTSIIELMHLKCKCHGLSGSCEVKTCWWSQPDFRVIGDYLKDKYDSASEMVVEKHRESRGWVETLRPKYNFFKAPTEKDLVYYENSPNFCEPNPETGSFGTRDRICNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVRCQECIRVYDVHTCK
Protein: Oleate hydroxylase FAH12 (CpFAH) (CpFAH12) (EC 1.14.-.-) (Oleate Delta(12)-hydroxylase) (B4YQU1)
Organism: Claviceps purpurea (Ergot fungus) (Sphacelia segetum)
Function: Oleate hydroxylase involved in the biosynthesis of ricinoleate. Exhibits delta(12) hydroxylase activity on 16C and 18C monounsaturated fatty acids (e.g. oleic and palmitoleic acids), and, to a lower extent, gamma(3) hydroxylase activity on ricinoleic acid. It uses cytochrome b5 as an electron donor. May act on both oleic acid (18:1(9cis)) and eicosenoic acid (20:1(11cis)) (By similarity).
Subcellular location: Microsome membrane {ECO:0000250|UniProtKB:Q41131}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASATPAMSENAVLRHKAASTTGIDYESSAAVSPAESPRTSASSTSLSSLSSLDANEKKDEYAGLLDTYGNAFTPPDFSIKDIRAAIPKHCYERSTIKSYAYVLRDLLCLSTTFYLFHNFVTPENIPSNPLRFVLWSIYTVLQGLFATGLWVIGHECGHCAFSPSPFISDLTGWVIHSALLVPYFSWKFSHSAHHKGIGNMERDMVFLPRTREQQATRLGRAVEELGDLCEETPIYTALHLVGKQLIGWPSYLMTNATGHNFHERQREGRGKGKKNGFGGGVNHFDPRSPIFEARQAKYIVLSDIGLGLAIAALVYLGNRFGWANMAVWYFLPYLWVNHWLVAITFLQHTDPTLPHYNREEWNFVRGGACTIDRDLGFIGRHLFHGIADTHVVHHYVSRIPFYNADEASEAIKPIMGKHYRSDTAHGPVGFLHALWKTARWCQWVEPSADAQGAGKGILFYRNRNKLGTKPISMKTQ
Protein: Ras-related protein Rab-38 (EC 3.6.5.2) (Q8QZZ8)
Organism: Mus musculus (Mouse)
Function: Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7. Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P57729}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome {ECO:0000269|PubMed:26620560}. Melanosome membrane {ECO:0000250|UniProtKB:P57729}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization. {ECO:0000250|UniProtKB:P57729}.
Interaction partners:
- Ankyrin repeat domain-containing protein 27
- BLOC-3 complex member HPS4
- BLOC-3 complex member HPS1
- Geranylgeranyl transferase type-2 subunit alpha
- Rab proteins geranylgeranyltransferase component A 1
- AP-3 complex subunit beta-1
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
Sequence:
MQTPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGVDFALKVLHWDPETVVRLQLWDIAGQERFGNMTRVYYREAMGAFIVFDVTRPATFEAVAKWKNDLDSKLTLPNGKPVSVVLLANKCDQGKDVLMNNGLKMDQFCKEHGFVGWFETSAKENINIDEASRCLVKHILANECDLLESIEPDIVKPHLTSPKVVSCSGCAKS
Protein: Radixin (cDNA, FLJ93349, Homo sapiens radixin (RDX), mRNA) (B0YJ88)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Interaction partners:
Sequence:
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
Protein: Fibronectin type-III domain-containing protein (A0A060WMK8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Uncharacterized protein
- Interferon/interleukin receptor domain-containing protein
- Fibronectin type-III domain-containing protein
- Fibronectin type-III domain-containing protein
- Fibronectin type-III domain-containing protein
- Interferon alpha-2-like
- Fibronectin type-III domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Type I interferon b3
Sequence:
MVGIGLAHISLIFVLCQRHVDSYVPPPVNVSLICHNFHNVIYWNYSEPSLQPQFNVEMTRKYSGAALVCSNTSLYHCDVSSFTKVIEEGYRFILTAVGQNTNSPEISFTYDDTVYSDVVVHCSLDFPPVNISAVSDQIIKVQFIHPFHIYKYAIIKNERPDHKEFHYMVVAEDPLKEHSFTCSYKQHHVCEAEIPVDGKMDRHCVKMKGKMNNVHVSAHQNICIEGKHGDSGPSYTALYIVIPIVAMVVIAFIVWLIYRXXXXXXXLCFGLPIEPELCFGLPIEPELCFGLPIEPALCFGLPIEPALCFASS
Protein: Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2) (P13056)
Organism: Homo sapiens (Human)
Function: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Nucleus, PML body {ECO:0000250}. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. {ECO:0000250}.
Interaction partners:
- Nuclear receptor-interacting protein 1
- Histone deacetylase 3
- Nuclear receptor subfamily 2 group C member 2
- Nuclear receptor corepressor 1
- Histone deacetylase 4
Sequence:
MATIEEIAHQIIEQQMGEIVTEQQTGQKIQIVTALDHNTQGKQFILTNHDGSTPSKVILARQDSTPGKVFLTTPDAAGVNQLFFTTPDLSAQHLQLLTDNSPDQGPNKVFDLCVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLTATPTFVTDSESTRSTGLLDSGMFMNIHPSGVKTESAVLMTSDKAESCQGDLSTLANVVTSLANLGKTKDLSQNSNEMSMIESLSNDDTSLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSSVAGMEGSVHLITGDSSINYTEKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSTERRKLLMEHIFKLQEFCNSMVKLCIDGYEYAYLKAIVLFSPDHPSLENMEQIEKFQEKAYVEFQDYITKTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNIRIDSVIPHILKMEPADYNSQIIGHSI
Protein: Omega-hexatoxin-Hv2a (Omega-HXTX-Hv2a) (Omega-atracotoxin-Hv2a) (AcTx-Hv2) (Omega-AcTx-Hv2a) (P82852)
Organism: Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Function: Potent inhibitor of insect (bee brain), but not mammalian (rat trigeminal neurons), voltage-gated calcium channels (Cav). As for omega-AcTx-Hv1a, the phenotypic effect of injection of this toxin into lone star ticks (Amblyomma americanum) is curling of all eight legs into closed loops, followed by death.
Subcellular location: Secreted {ECO:0000269|PubMed:11522785}.
Interaction partners:
Sequence:
LLACLFGNGRCSSNRDCCELTPVCKRGSCVSSGPGLVGGILGGIL
Protein: scyllo-inositol 2-dehydrogenase (NADP(+)) IolU (EC 1.1.1.371) (NADP(+)-dependent scyllo-inositol dehydrogenase 2) (NADP(+)-dependent SI dehydrogenase 2) (O05265)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the NADPH-dependent reduction of scyllo-inosose (SIS) to scyllo-inositol (SI) in vitro, but is unable to dehydrogenate scyllo-inositol and myo-inositol. Is less efficient than the functional paralog IolW. Under physiological conditions, may primarily function as an NADPH-dependent oxidoreductase that reduces carbonyl group(s) in its substrates. Cannot use NADH instead of NADPH.
Interaction partners:
- scyllo-inositol 2-dehydrogenase
- Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
- Inosose dehydratase
- Inosose isomerase
- scyllo-inositol 2-dehydrogenase
- Uncharacterized oxidoreductase YrbE
- Putative oxidoreductase YteT
- Uncharacterized oxidoreductase YfiI
- Glycerol-3-phosphate cytidylyltransferase
- Probable tartrate dehydrogenase/decarboxylase
Sequence:
MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAAKHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKETEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFRSGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILSYDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPKPAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA
Protein: Zinc finger A20 and AN1 domain-containing stress-associated protein 9 (AtSAP9) (O49663)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in environmental stress response.
Interaction partners:
- Ubiquitin receptor RAD23d
- Zinc finger AN1 and C2H2 domain-containing stress-associated protein 13
- Immune-associated nucleotide-binding protein 1
Sequence:
MGSEQNDSTSFTQSQASEPKLCVKGCGFFGSPSNMDLCSKCYRGICAEEAQTAVAKAAVEKSFKPSPPRSLFIAEPPAVVVEPKPEKAAVVVVSAEPSSSAVPEANEPSRPARTNRCLCCNKKVGIMGFKCKCGSTFCGEHRYPETHDCSFDFKEVGRGEIAKANPVVKADKIQRF
Protein: Sensitive to high expression protein 9 homolog, mitochondrial (Q9P6N3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
Sequence:
MLQRLSQSIKGFAARFPKIYNKGNGSVQQTILQASQRLNELTGYSSIEALKNAVVKQETKLRDFRLSAAEARKRYIEAVEKRSSSQREVNELLQRRSSWSTIDLERFTKLYRDDYSNKEEEIKAQEDVDVAERRVEEAQNGLVRSILSRYHEEQVWSDKIRQASTWGTWGLMGINVVLFVVVQLILEPRKRKRLVREAVDHIDKERELEINDELKKISEKLDKKGEAVGQALELTSPKIDNKNLPKNSASLILPPINYDTFHSFLDSLKYFLSRFLSTDYRIQLTYRQLSILATKFTVGGGVIIYTFIHLFGLAFKR
Protein: Arabinose 5-phosphate isomerase GutQ (API) (G-API) (EC 5.3.1.13) (Phosphosugar aldol-ketol isomerase) (P17115)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). It appears that the physiological function of G-API may be to synthesize the regulatory molecule A5P, which in turn participates in the induction of the gut operon through an unknown mechanism. It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs).
Interaction partners:
- 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
- Glucitol operon activator protein
- Glucitol operon repressor
- 2-dehydro-3-deoxyphosphooctonate aldolase
- 3-deoxy-manno-octulosonate cytidylyltransferase
- Tetraacyldisaccharide 4'-kinase
- 3-deoxy-D-manno-octulosonic acid transferase
- UDP-3-O-acyl-N-acetylglucosamine deacetylase
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- UDP-3-O-
Sequence:
MSEALLNAGRQTLMLELQEASRLPERLGDDFVRAANIILHCEGKVVVSGIGKSGHIGKKIAATLASTGTPAFFVHPAEALHGDLGMIESRDVMLFISYSGGAKELDLIIPRLEDKSIALLAMTGKPTSPLGLAAKAVLDISVEREACPMHLAPTSSTVNTLMMGDALAMAVMQARGFNEEDFARSHPAGALGARLLNKVHHLMRRDDAIPQVALTASVMDAMLELSRTGLGLVAVCDAQQQVQGVFTDGDLRRWLVGGGALTTPVNEAMTVGGTTLQSQSRAIDAKEILMKRKITAAPVVDENGKLTGAINLQDFYQAGII
Protein: Immunity-related GTPase family M protein 3 (EC 3.6.5.-) (Interferon gamma-induced GTPase) (Q9DCE9)
Organism: Mus musculus (Mouse)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:18765738, ECO:0000269|PubMed:9099712}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18765738, ECO:0000269|PubMed:23785284}. Lipid droplet {ECO:0000269|PubMed:23785284}. Note=Delivered to the parasitophorous vacuole via the cell endoplasmic reticulum early after invasion (PubMed:18765738). It then condenses into vesicle-like structures on the vacuole just prior to parasitophorous vacuole disruption (PubMed:18765738). Mainly associates with lipid droplets and 'self' cytoplasmic vacuoles, while it only weakly coats 'non-self' pathogen-containing vacuoles (PubMed:23785284). {ECO:0000269|PubMed:18765738, ECO:0000269|PubMed:23785284}.
Interaction partners:
- Immunity-related GTPase family M protein 2
- Signal transducer and activator of transcription 1
- Guanylate-binding protein 3
- Guanylate-binding protein 2
- Guanylate-binding protein 7
- GTP-binding protein
- Immunity-related GTPase family M protein 1
- Interferon regulatory factor 9
- Interferon-inducible GTPase 1
- Guanylate-binding protein 6
Sequence:
MDLVTKLPQNIWKTFTLFINMANYLKRLISPWSKSMTAGESLYSSQNSSSPEVIEDIGKAVTEGNLQKVIGIVKDEIQSKSRYRVKIAVTGDSGNGMSSFINALRFIGHEEEDSAPTGVVRTTKKPACYSSDSHFPYVELWDLPGLGATAQSVESYLEEMQISTFDLIIIVASEQFSSNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRENLQQAQVRDPPLFLISCFSPSFHDFPELRNTLQKDIFSIRYRDPLEIISQVCDKCISNKAFSLKEDQMLMKDLEAAVSSEDDTANLERGLQTYQKLFGVDDGSLQQVARSTGRLEMGSRALQFQDLIKMDRRLELMMCFAVNKFLRLLESSWWYGLWNVVTRYFRHQRHKLVIEIVAENTKTSLRKALKDSVLPPEIH
Protein: KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) (Q969R8)
Organism: Homo sapiens (Human)
Function: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:28199306}. Note=Localization to lysosomes is amino acid-independent. {ECO:0000269|PubMed:28199306}.
Interaction partners:
- GATOR1 complex protein DEPDC5
- KICSTOR complex protein SZT2
- GATOR1 complex protein NPRL2
- KICSTOR subunit 2
- KICSTOR complex protein kaptin
- GATOR2 complex protein WDR24
- GATOR2 complex protein WDR59
- Lysosome-associated membrane glycoprotein 1
- S-adenosylmethionine sensor upstream of mTORC1
- GATOR1 complex protein NPRL3
Sequence:
MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKVSVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLLVAVSAEGWFHLFDLTPAKVLDASGHHETLIGEEQRPVFKQHIPANTKVMLISDIDGDGCRELVVGYTDRVVRAFRWEELGEGPEHLTGQLVSLKKWMLEGQVDSLSVTLGPLGLPELMVSQPGCAYAILLCTWKKDTGSPPASEGPTDGSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIKQGHGTESSGSGLFALCTLDGTLKLMEEMEEADKLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLVKLLETKPEYHSLLQELGVDPDDLPVTRALLHQTLYHPDQPPQCAPSSLQDPT
Protein: NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (H3BNV2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
Sequence:
MKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK