wanglab/gogpt-training-data huggingface dataset:
Protein: O-methyltransferase mpaG' (EC 2.1.1.-) (Mycophenolic acid biosynthesis cluster protein G') (A0A0B5L781)
Organism: Penicillium brevicompactum
Function: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893. MpaG' methylates farnesyl-DHMP-3C (FDHMP-3C) to yield MFDHMP-3C. The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC. 5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE. MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB). MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP. The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP). The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate. The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C. After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight. Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps. The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process. Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (Probable).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:31209052}.
Interaction partners:
Sequence:
MSAASPASIIQELASAAKQYENNESGAREALIAQSRALIASLEVPSEFIQHTFWSQPALSAIVRLATDVNLFQYLKDAQEEGLNAEALASKTGMDVSLFARLARHLVAMNVITSRNGVFYGTALSNGLAAENYQQSIRFCHDVSRPSFGAFPSFFKGNGYKTPALGTTDGPFQSAHKVDISFPQWLVGNPPYLQYFNSYMSAYRAGKPNWCDNGFYPVADRLLNGFDASVSDVLLVDVGGGRGHDIATFGSQFSPLPGRLVLQDREQVINSIPADESRQFEATTHDIFTTQPVKHARAYYMHSVPHGFGDEDAVKIMANLVPALAKGYSRVLLNEIVVDEERPVMSATNMDLIMLAHMGAKERTEADWRSILTRAGLKVVNIYSYPGVAESLIEAELA
Protein: Intermediate filament protein ifa-2 (Cel IF A2) (Intermediate filament protein A2) (IF-A2) (O02365)
Organism: Caenorhabditis elegans
Function: Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle-cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos.
Subcellular location: Cell junction, hemidesmosome {ECO:0000269|PubMed:14597206}. Note=Colocalizes with myoactin.
Interaction partners:
- Intermediate filament protein ifb-1
- Intermediate filament protein ifc-2
- Intermediate filament protein ifa-1
- Intermediate filament protein ifp-1
- Intermediate filament protein ifd-1
- Intermediate filament protein ifc-1
Sequence:
MTDPDSYRSSITSRPSFNRTVTSSSQNYGAPGSGNRVLKIVTETHSSSVSSGLSPYGQNAASTIRDNREREKKEIMELNDRLASYIEKVRFLDAQNRKLDADLKMLQGRFGKSTGSVKVMYEMEITTATNVVKQTGKDHGETEKEIRKLQDQLDELRKKFEEAQRGRAEDRLKIDDLLVTLSNLEAEINLLKRRIALLEEEVARLKKENFRLTSELQRVRIELDQETLLRIDNQNKVKTILEEIDFMKRGFETELKELQAQAARDTTSENREYFKNELANAMRDIRAEYDQIMNGNRNDMESWYQLRVQEINTQSNRQNAENNYQKEEVKRLRNQTSELRQKLSDLESRNLLLEKQIEDLNYQLEDDQRSYEAALNDKDAQIRKLREECQALMVELQMLLDTKQTLDGELKVYRQMLEGNSEGNGLRQLVEKVVRTSAINEEADTETMRVVKGEHSSRTSYQRSAKGNVAIKETSPEGKFVILENTHRAKEEPLGDWKLKRKIDGKREIVFTFPSDYILHPFQSVKIFARGQGIANPPEVLIFEGDETFGVGANVQTILYNNKGEERATHIQRQSQQTTSS
Protein: Thioredoxin 3 (PfTRX3) (Q4VWQ3)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21203490}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Small ribosomal subunit protein eS30
- UV excision repair protein RAD23
- Ribosomal protein S27a, putative
- Polyubiquitin
- Ubiquitin-like protein, putative
- Ubiquitin domain-containing protein DSK2, putative
- Ubiquitin-like protein nedd8 homologue, putative
- Putative cell division cycle ATPase
- Cell division cycle protein 48 homologue, putative
- AAA family ATPase, putative
Sequence:
MALICIGSVCFSLFHIGVIILLIINYFSSHIKKIFPSFFKNPNKEEIDKHIGNILEAKRKNKQLEQSIYIELKNTGSLNQVFSSTQNSSIVIKFGAVWCKPCNKIKEYFKNQLNYYYVTLVDIDVDIHPKLNDQHNIKALPTFEFYFNLNNEWVLVHTVEGANQNDIEKAFQKYCLEKAK
Protein: Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC-1 subunit 1) (Q22616)
Organism: Caenorhabditis elegans
Function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in gut granule biogenesis. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation.
Subcellular location: Mitochondrion intermembrane space {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- SNAPIN protein homolog
- KxDL domain-containing protein
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- BLOC-1-related complex subunit 8 homolog
- Dysbindin protein homolog
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- BLOC-1-related complex subunit 6 C-terminal helix domain-containing protein
Sequence:
MLKEHSKKQHLRREVQEKLKNEAIVAAQTLSTAVVDHLNAKVAQAYGNQKRLDVEAKRFENNSAALAKQTEQWLFITEGLNYALKEIGDVENWSKTIENDMKIITETLRRAYEAKNPPLPPNQANPASH
Protein: Acrosin-binding protein (Acrosin-binding protein, 60 kDa form) (Proacrosin-binding protein sp32) [Cleaved into: Acrosin-binding protein, mature form (ACRPB-C) (Acrosin-binding protein, 32 kDa form, mature form) (Sp32)] (Q3V140)
Organism: Mus musculus (Mouse)
Function: Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.
Subcellular location: [Isoform 2]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:27303034}. Note=Colocalized with pro-ACR in the acrosomal granules of early round spermatids. {ECO:0000269|PubMed:23426433}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:22357636, ECO:0000269|PubMed:23426433, ECO:0000269|PubMed:27303034}. Secreted {ECO:0000250|UniProtKB:Q29016}. Note=Highly enriched in acrosomal granules of round spermatids, and spread over the apical end of the nucleus in elongating spermatids. Colocalized in the acrosome of epididymal sperm with pro-ACR. {ECO:0000269|PubMed:23426433}.
Interaction partners:
- Zona pellucida-binding protein 2
- Zona pellucida-binding protein 1
- Acrosin
Sequence:
MMNLAAGFLLMLLEVLLLPGTPLSAEESPASTPGSPLSSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPPTSMTTPIVSHATATEHQAFQPWPERLNNNVEELLQSSLSLGGKDQQSSRRPGQEQRKQEQIQEHKLEEAQEQEEQEEEEEEEEAKQEEGQGTEAGLESVSRLQSDSEPKFQSQSLSSNPSFFTPRVREVESAPLMMKNIQELIRSAQEMDEMNELYDDSWRSQSTGSLQQLPHMETLMVLCYSIMENTCTMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQKCDASHKIPFISPLLSAQSISTGNQARIPDKGRFAGLEMYGGLSSEFWCNRLAMKGCEDDRVSNWLKAEFLSFQEGDFPTKICDTNYIQYPNYCSFKSQQCLLRNQNRKMSRMRCMLNERYNVLSLAKSEEVILRWSQEFSTLAIGQFG
Protein: Host cell factor 2 (HCF-2) (C2 factor) (Q5RKG2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Y5Z7}. Nucleus {ECO:0000250|UniProtKB:Q9Y5Z7}.
Interaction partners:
- Host cell factor 1
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Retinoblastoma-binding protein 5
- WD repeat-containing protein 5
- [histone H3]-lysine
- Histone-lysine N-methyltransferase 2B
- [histone H3]-lysine
- Histone-lysine N-methyltransferase
- CXXC-type zinc finger protein 1
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Sequence:
MAAPSLLNWRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGNEGIADELHVYNTVTNQWFLPAVRGDIPPGCAAHGFVCDGTRILVFGGMVEYGRYSNELYELQASRWLWKKVKPQPPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSVPATKGTVPSPRESHTAVIYCKRDSGSPKMYVFGGMCGARLDDLWQLDLETMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGENTENSPHDCEWRCTSSFSYLNLDTAEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYFWSGRDGYKKALNSQVCCKDLWYLDTEKPPAPSQVQLIKATTNSFHVKWDEVPTVEGYLLQLNTDLTHQAASPDASAAPNTLGGRTDPHRQGSNSILHNSVSDPANCTKPEHTAVAARGMSLKSKPDSRAADSSVALHSPLAPNTSNNNSCMADMLWKSEVDEICALPATKISRVEAHAAATPFSKETPSNPVAILKAEQWCDVGIFKNNTALVSQFYLLPKGKQSMSKVGNADVPDYSLLKKQDLVPGTVYKFRVAAINGCGIGPFSKLSEFKTCIPGFPGAPSTVRISKNVEGIHLSWEPPTSPSGNILEYSAYLAIRTAQVQDNPSQLVFMRIYCGLKTSCIVTAGQLANAHIDYTSRPAIVFRISAKNEKGYGPATQVRWLQGNSKKAPLS
Protein: Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (A0A8I5ZYM4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDEKGDKKNQQQQQGNNHTNGTGHPGNQDSGHAQGPPLKKVRVVPPTTTSGGLIMTSDYQVLHVSPTDLLFWGF
Protein: Syntaxin ufe1 (O94531)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Syntaxin required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
- Protein transport protein sec22
- Sad1-interacting factor 1
- Protein transport protein use1
- Protein transport protein sec20
- AP-1 complex subunit mu-1
- AP-2 complex subunit mu
- Protein sey1
- Glutathione S-transferase 3
- Dynein light chain Tctex-type
- Acetyl-CoA carboxylase
Sequence:
MTSRTNEFFGLTKNGDIDAANIPLKRISYTDPFLAEGYRIHETIVNLLVFLKKIRGAYLKDRTFSNVQRLSKPLMECSLEELSKLELDEVQRDEIEHEVSSAISSCIHQIAKLQEIVKEQQSQIPKKSGWLQGLRDPSKLSKKETLVAHHSSVLWYLQSELSDVSSVLYHLQDLRLKRGQEKRNIASDFLTKNPTDENSAVEIPESELQTFFTQQQLQELEQENDVLLQEFEHTMERLRDTGKSLADITRLQSEISAQLSIQSSAAEKLYDDALNVMDSLSGGNQQLIKAKSRSSRTARLLFCIFTVMGLLLLSLDRIV
Protein: Alpha-thujene synthase TPS3, chloroplastic (EC 4.2.3.-) ((+)-sabinene synthase TPS3) (EC 4.2.3.110) (Terpene synthase 3) (LcTPS3) (G0Y7D3)
Organism: Litsea cubeba (Aromatic litsea) (Laurus cubeba)
Function: Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products used by traditional Chinese medicine to treat headache, inflammation and intoxication (Ref.1). Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) into alpha-thujene and (1R,5R)-sabinene (Ref.1).
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MALQLLTPSFSFQHSPSPHRLTTLRYTHHTIRCTASAPSYSDLVGRRSANYKPSKWDSNFVETLESDYKKENHEMYIEKLMGDVKHLMKKVVNPIEKMELVDTIQRLGLGYLFNKEIKEVLNTIATSKATFKTKKDLHAVALQFRLLRQHGYEVSPDAFHKFKDEKGGFKESLCMDIKGMLSLYEASHLSFQGEVVLDEAREFTSTHLKAIEGNIDPVLLKKVRHSLEMPLHWRMLRLEARWYIETYDEEDRKNPSLAELAKHDFNSVQTIYQRSLKRMSRWWRDLGLGERLEFSRDRLVECFFWTTGVIFDPQFERCRGVLTKVNQLVSTIDDVYDVYGSLEELELFTDAVDRWDIRAMEQLPEYMKICYLALYNTTNDIAYEALKEEGLDVIPYLKKVWTDLCKSYIVEARWYSNGYKPTLEEYLENAWTSIAGPVALGHAYFSFGQKMPFEALNYSNTSSLIKWSSMIFRLCDDLATSSDEVARGDVPKSIQCYMYEAGVSESVARDHIKYLIDEAWKKMNECLVPSTPFLQPLINAGFNLARMAHCMYEHGDGHGFSNELDKKRVLLLLAEPFKFM
Protein: Nuclear receptor subfamily 5 group A member 2 (FTZ-F1 homolog) (zFF1) (Liver receptor homolog 1) (LRH-1) (Q90YL6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P45448}. Chromosome {ECO:0000250|UniProtKB:P45448}.
Interaction partners:
- Nuclear receptor coactivator 3
- Catenin beta-1
- Nuclear receptor subfamily 0, group B, member 1.
- Zinc finger protein 217
- Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
- Nuclear receptor subfamily 0 group B member 2
- Aromatase
- Nuclear receptor subfamily 0, group B, member 2b.
- Pancreas transcription factor 1 subunit alpha
- Homeobox protein Hox-B7a
Sequence:
MLPKVESEYLGLARSHGEQGHMPGNMQAPQFKMMDYSYDEDLDEMCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCQIDKTQRKRCPYCRFQKCLTVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMTQVMQTVPADLTITSAIQNIHSASKGLPLSHHHHHHHHHHHHSSSSAGLPPADFDRSPFVTSPVSMAMPPHAGGLQGYQAYGHFQSRTIKSEYPDPYTSSPESLMGYPYVEAYAGGSPPSFPHLVVELLKCEPDEPQVQAKILAYLQQEQASRGKHEKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHVFRQVMHAKEGSILLVTGQQVDYALIASQAGATLNNLLSHAQELVSKLRSLQLDQREFVCLKFLVLFSLDVKNLENFHLVESVQEQVNAALLDYVMCNYPQQTDKFGQLLLRLPEIRAISLQAEEYLYYKHLNGDVPCNNLLIEMLHAKRA
Protein: RNA helicase (EC 3.6.4.13) (O83538)
Organism: Treponema pallidum (strain Nichols)
Interaction partners:
- Probable peptidyl-prolyl cis-trans isomerase
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS11
- Cytidylate kinase
- Small ribosomal subunit protein uS4
- Uncharacterized protein TP_1029
- RNA helicase
- RNA-binding protein, putative
- Ankyrin, putative
- Putative ankyrin repeat-containing protein TP_0502
Sequence:
MFSYKQLPVYSQKDKILSALAHHHVIVVESPTGSGKTTQLPLILHEAGYNEGGAIGVTQPRRIAVLSVSEFIAKQVLHVQPGIVGYKMRFEDHTDVETKIKVMTDGILLQEMKLDPLLSKYSIIMVDEAHERSLNIDFILGLLKRVLQQRHDFRIVISSATINTAMFSRYFNECPVIKIDAVAYPVTVIFDPPDTPASTHTKEAEAALLEKIVCIVERVIASRDKGAILIFLPGERSIKNCITRLSHERWFRKLFLLPLYGRLSKEEQEQVFNRAPFGKRKVVIATNIAETSITIDDVTTVIDSGLVKLNSYNPLSYTASLDETPISQASCNQRRGRAGRVRAGTCYRLYSRDDFEQREPYTLEEIYRTDLSEVVMRMAELGIHDFEHFDFISPPGTHGIIGAEDTLRLLGALEDDRSLSEIGKMMCLFPLGPRQSRMIVEALRRYPHSIDDVLIAAAFLSARSPLIFSEDQEEKTKKAHGTFSDPMGDFVSFLRIYRAYAQENNKHSFCQHFYLDERIMAEISNIKEQLELIVSGMGFPLLTGGTVEEYLICVGTGMIQFVCVQEHRDSYRSLTAECIHIHPGSCVYKDRPKFIVAGEIVRTSRMYAMSVSPLSKKIAELIAPALLERRGRAEKHGTSPTRAAFLKKSTLRKGPRKRRVRVGRASLR
Protein: Sprouty-related protein with EVH-1 domain, isoform C (A0A0B4KG11)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Neurofibromin 1, isoform B
- Ras-like protein 1
- Titin
Sequence:
MTEGHESDFLVTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSPLASGHDYIIYGQRISDQSVILSCVINRDLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDGLAKSNPTIICPPLTKYDSVGEDDVFMTLDLPVESESLQKIHSSPEGSEKSHKSVSNNSDSEKLPPPPIHYISTDKTSATTSPPDAPPASAAPSPATAGQIAASENYSYVTLTAVHHDYNYPVVDQPVGAQVLNARRESISALKKRNALEAAQAMAAAQTAAGGGLACRDGGSGKPLHKPNVSDILKKETRLRCRYCHELYSEDFNRRGACEYAPDAFRSGYECISGMGCARCMIYHCMSDAEGETAQHPCDCSASEAGCSKRWLGLAILSLFVPCLWCYPPLRACHLAGIHCGLCGGQHKPHVXHLEARLQGQHDDDPRPRSEFHYHHSEQSIMNSAKRPWGAKQKQSQQSQQSQRHFYNWELSHSLGAPQHQTPPYLMQSTGRKAPQNDYGRLLF
Protein: 2-methylfumaryl-CoA isomerase (EC 5.4.1.3) (A9WC36)
Organism: Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Function: Involved in the glyoxylate assimilation cycle used to regenerate acetyl-CoA and produce pyruvate as universal precursor for biosynthesis. This reaction involves an intramolecular CoA transferase that catalyzes the reversible transfer of the CoA moiety from the C1-carboxyl group of mesaconyl-CoA to the C4-carboxyl group. It does not require free mesaconate as CoA acceptor.
Interaction partners:
- Mesaconyl-C
- Beta-methylmalyl-CoA dehydratase
- Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase
Sequence:
MKGILHGLRVVEGSAFVAAPLGGMTLAQLGADVIRFDPIGGGLDYKRWPVTLDGKHSLFWAGLNKGKRSIAIDIRHPRGQELLTQLICAPGEHAGLFITNFPARGWLSYDELKRHRADLIMVNLVGRRDGGSEVDYTVNPQLGLPFMTGPVTTPDVVNHVLPAWDIVTGQMIALGLLAAERHRRLTGEGQLVKIALKDVGLAMIGHLGMIAEVMINDTDRPRQGNYLYGAFGRDFETLDGKRVMVVGLTDLQWKALGKATGLTDAFNALGARLGLNMDEEGDRFRARHEIAALLEPWFHARTLAEVRRIFEQHRVTWAPYRTVREAIAQDPDCSTDNPMFAMVEQPGIGSYLMPGSPLDFTAVPRLPVQPAPRLGEHTDEILLEVLGLSEAEVGRLHDEGIVAGPDRAA
Protein: Uncharacterized protein (Q57Z34)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MITLKTAVNTRAPLRERAVPLDRDKRLVPSQSSLHHGIYTTFDEAYGSAPARTDPSQGNHYLTLLRSVRCGANKTNEATADTKTTVDDKACGGEMKPRGHLEGTMKSSVASLFDGVATRHSPSEWITEQQASSQSVRPVAQRDFYSTARRVERIDDDMRSGLVGNTQRTVDIMRKRATSPTLCPNPDVFPVFPAQRRLLDTDADGRCARSCLDIVDCQRLAPPSENHLGFEYAPLDRLAPKLPVSPALAVQQRLITDMSSSMPLFAGTAKVQKYAIPRYAGHVPSFPRNVDALHGNDTCPLRKWSKSYVTLATVGCGTDAGRRNKNPLVRNRSGTKAPETKPMKPKTSEVIKMTVEGSMLQTTLTQLTDAEQTLNTRVDKKPRKLF
Protein: Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8) (Q84K25)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. Involved in pollen tube growth by modulating Golgi morphology and vesicle trafficking homeostasis leading to the deposition of cell wall components and proteins at the pollen tube tip. Required for sporophytic development.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:27448097}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96MW5}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 2
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 5
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 4
- Conserved oligomeric Golgi complex subunit 7
- Vacuolar protein sorting-associated protein 54, chloroplastic
- Vacuolar protein sorting-associated protein 53 A
- Vacuolar protein sorting-associated protein 52 A
Sequence:
MAMEVGEMSQPEATASLLSLASATQQPYVSELLSFTLDRLHKEPELLRVDAERIQRQMQEVAVGNYRAFITAADALLAIRQEVSSIDKHLESLIGEVPKLTSGCTEFIDSAENILEKRKMNQALLANHSTLLDLLEIPQLMDTCVRNGNFDEALDLEAFVSKLATLHPKLPVIQALAAEVRQTTQSLLSQLLQKLRSNIQLPECLRIIGYLRRIGVFGEYEMRLQFLRCREAWLTGILEDLDQKNAYEYLKGMINCHRMHLFDVVNQYRAIFSDDTSGSEENYDGGLLFSWAMHQITSHLKTLKIMLPKITEGGSLSNILDQCMYCAMGLGGVGLDFRGLLPPLFEEAVLNLFSKNMSTAVENFQLVLDSHRWVPLPSVGFPSSGINEDSKDDVTPPSYLMEHPPLAVFINGVSSALNELRPCAPLSLKNVVAHELIKGLQAVSDSLLRYNTTRMLRLSESNLFLSLCRAFVEVVFPHCATCFGRCYPGGATIVMDAKSAYEGLGRILAASSSQEPSNKSPKVISTDTKDASENGVASQPEEKQAENPNAKEEDNSPIPLQTPEITPES
Protein: Oligo-1,6-glucosidase IMA4 (EC 3.2.1.10) (Alpha-glucosidase) (Flocculent-specific protein 2) (Isomaltase 4) (P0CW41)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides. Not required for isomaltose utilization, but overexpression allows the IMA1 null mutant to grow on isomaltose.
Interaction partners:
Sequence:
MTISSAHPETEPKWWKEATIYQIYPASFKDSNNDGWGDMKGIASKLEYIKELGTDAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWRSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVAGLPDAPVIDENSKWQLSDPFTMNGPRIHEFHQEMNKFIRNRVKDGREIMTVGEMRHATDETKRLYTSASRHELSELFNFSHTDVGTSPKFRQNLIPYELKDWKVALAELFRYVNGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLVSLSGTLYVYQGQELGEINFKNWPIEKYEDVEVRNNYDAIKEEHGENSKEMKRFLEAIALISRDHARTPMQWSREEPNAGFSGPNAKPWFYLNESFREGINAEDESKDPNSVLNFWKEALRFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYDNKTLFAALNFSSDSIDFTIPNNSSSFKLEFGNYPRSEVDASSRTLKPWEGRIYISE
Protein: Uncharacterized protein (Q57UU0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKSANVPTENVLSQVTHLTPVDVSELLVRRGGVEPVISPPRAGVYFGQLPHGFGRMVSETKNHCLHWSSHDVTRSPAVCFPVVGDILRREKRSEMIQLTHKDGATSFFAPQKRERGRIEALLFLGSAEGGHTQMFRPVHNSWSFHAQMLTGTERNGLCTTSQFMELFLKKLVMWVFYYLARTSATYITIYNLEMAFPILTAISLQDRRYLVEEAANRFALGMLSYYDDRIICRQRPPVNAVLLLSTEELRSVTSVEQASAAFIYRCQMKHNTILSALQYIIEYWGKRSTVFRSSVIQQAVSIILSHVSCTYSLLPALGAKSWIRTCTFRHMLLLLSQRGETLATSIVSTLRSSRPLKASRCAEFSKMLEQLVLTEPLAVGPVSDTSEMHEVEDVFFLESVTLESNPNTKTVWKAEKNTFRFASVPSADIPSVSDKQLIGNSADLLFATALYSCGRLQFSLPLLKCAHAKAETCLKLHLGGDLFVDSDSDSEKVVWRSLRMGKRRRKGY
Protein: Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (Q6AYI1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Ribonuclease 3
- RNA helicase
- ATP-dependent RNA helicase A
- Homeobox protein NANOG
- Serine/arginine repetitive matrix 2
- Spliceosome RNA helicase Ddx39b
- Serine/arginine-rich splicing factor 5
- Estrogen receptor
- Exosome RNA helicase MTR4
- UPF3B, regulator of nonsense mediated mRNA decay
Sequence:
MSSYSSDRDRGRDRGFGAPRFGGSRTGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVDTYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVANMHNGMNQQAYAYPATAAAAPMIGYPMPTGYSQ
Protein: Uncharacterized transporter YIL166C (P40445)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Alpha-ketoglutarate-dependent sulfonate dioxygenase
- Homocysteine/cysteine synthase
- Glutaredoxin-8
Sequence:
MSVQKEEYDIVEKAQLSVSAESLTSDSESISHNPFDDFHKAERWRKVYESSGYEGLSKFDPEFTWTKDEEKKLVRKMDLKIFLWVFIMFAFLDLIRKNIARAVSDNFIVDLKMNTNDYNLGQTVYLVIFLASELPGNLLSKRFGPERVIPVQIVLWSVICITQAGLKNRGQFIATRCLLGMVQGGFIPDNILYLSYYYTGAELTFRLSFFWCAIPLFQILGSLLASGIIEMRGIHNLAGWQYLFIIEGFLSLSVGVASFYLMRRGPTQTGESAFHKGKSLFTEYEEKIMVNRILRDDPSKGDMSNRQPVTFKEILYTLTEFDLWPLFIQGITAFISLQTVGSYLSLILKSLNYSTFLSNILAIPGQALLLINLPLAALLSRKLKEKSLCVGIANVWVLPFIVSLVALPTDTNPWIKYILLTGILGLPYTHSILAGWVSEISNSVRSRTVGTALYNMSAQVGAIIASNMYRNDDKPYYTRGNKILLGFTCFNICMAVATKFYYISRNKYKDRKWNSMTKEEQINYLDTTKDKGMKRLDYRFIH
Protein: Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Q382Q3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribonucleoside-diphosphate reductase
- thioredoxin-dependent peroxiredoxin
- thioredoxin-dependent peroxiredoxin
- dTMP kinase
- dTMP kinase
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase, putative
- Nucleoside diphosphate kinase, putative
- Guanylate kinase, putative
- Guanylate kinase, putative
Sequence:
MPPKSHKRSRKEGEVEEPLLTENPDRYVIFPIKYPDIWQKYKEAESSIWTVEEIDLGNDMTDWEKLDDGERHFIKHVLAFFAASDGIVLENLAERFMCEVQVPEVRCFYGFQIAMENIHCETYSVLIDTYVVDPDEKQRLLHAIRTIPCIEKKAKWAIEWIGSQTSFPTRLVAFAAVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLYEKYIVNKLPRDRVLEIICNAVSIEREFICDALPVRLIGMNSQLMTQYIEFVADRLLVSLGYDRHCNSKNPFDFMDMISLQGKTNFFEKKVGEYQKAGVMSSERSSKVFSLDADF
Protein: Aryl hydrocarbon receptor nuclear translocator-like 1b (BHLH-PAS transcription factor) (Basic helix-loop-helix ARNT like 1b) (Q8JIG1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADQRMDISSTMNEFMSPSSTELISSSMGSTGMDFNRKRKGSITDYEIDGFSFEDSMDTDKDKPLGRADQQMKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGAANPYTEANYKPAFLSDDELKHLILKAADGFLFVVGCDRGKILFVSESVYKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVRTDIAPSPSRLCSGARRSFFCRMKCNRSMVKMEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHPHIVPQPVNGDIRVKPTEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSFYEYFHQDDIGHLAECHRQVLQMREKINTHCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVSGSSVDGAEPGFPQLSASPQSMDSVLTAADGSGKTVPGLPGGTRAGAGKIGRMIAEEVMEIHRIRGSSPSSCGSSPLNISNSTPPPDTSSPAARKMSNGGTPDIPSAGLGSGQDSIGYPYSNSSILSDNSHIGIGDIMDEPGSSSPSSDEAAMAIIMSLLEADAGLGGPVDFSDLPWPL