wanglab/gogpt-training-data huggingface dataset:
Protein: Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (AtCAND1) (Protein ENHANCER OF TIR1-1 AUXIN RESISTANCE 2) (Protein HEMIVENATA) (Q8L5Y6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (By similarity). Required for SCF(TIR1) function. Modulates SCF(TIR1) function through its interactions with the CUL1 subunit. Represses photomorphogenesis by promoting HY5 degradation in darkness.
Interaction partners:
- Cullin-1
- RING-box protein 1a
- Cullin-4
- RING-box protein 1b
- Cullin-like protein 5
- Putative cullin-like protein 4
- Cullin-2
- Elongin-C
- Cullin-3A
- NEDD8-like protein RUB3
Sequence:
MANLQVSGILEKFQMTGKDKDYRYMATSDLLNELNKDSFKIDLDLEVRLSSIILQQLDDVAGDVSGLAVKCLAPLVKKVGEERIVEMTNKLCDKLLHGKDQHRDTASIALRTVVAQIAPTLAPSILVTLTPQMIGGISGQGMSSGIKCECLEIMCDVVQKYGSLMTDDHEKLLNTLLLQLGCNQATVRKKTVTCIASLASSLSDDLLAKATVEVVKNLSNRNAKSEITRTNIQMIGALCRAVGYRFGTHLGNTVPVLINYCTSASENDEELREYSLQALESFLLRCPRDISPYCDEILNLTLEYISYDPNFTDNMEEDTDNETLEDEEDDESANEYTDDEDASWKVRRAAAKCLAGLIVSRSEMLTKVYQEACPKLIDRFKEREENVKMDVFNTFIDLLRQTGNVTKGQTDTDESSPKWLLKQEVSKIVKSINRQLREKSVKTKVGAFSVLRELVVVLPDCLADHIGSLVPGIERALNDKSSTSNLKIEALVFTKLVLASHAPPVFHPYIKALSSPVLAAVGERYYKVTAEALRVCGELVRVVRPSTAGMGFDFKPFVHPIYNAIMSRLTNQDQDQEVKECAITCMGLVISTFGDQLRAELPSCLPVLVDRMGNEITRLTAVKAFSVIATSPLHINLSCVLDHLIAELTGFLRKANRVLRQATLITMNTLVTAYGDKIGSEAYEVILVELSSLISVSDLHMTALALELCCTLMTGKSCSENISLAVRNKVLPQALTLVKSPLLQGQALLDLQKFFEALVYHANTSFYTLLESLLSCAKPSPQSGGVPKQALYSIAQCVAVLCLAAGDKNCSSTVKMLMEILKDDSGTNSAKQHLALLSLGEIGRRKDLSAHAGIETIVIESFQSPFEEIKSAASYALGNIAVGNLSNYLPFILDQIDNQQKKQYILLHSLKEVIVRQSVDKADFQNSSVEKILALLFNHCESEEEGVRNVVAECLGKMALIEPEKLVPALQVRTTSPAAFTRATVVTAVKYSVVERPEKLDEIIFPQISSFLMLIKDGDRHVRRAAVSALSTFAHYKPNLIKGLLPELLPLLYDQTVIKKELIRTVDLGPFKHVVDDGLELRKAAFECVFTLVDSCLDQVNPSSFIVPFLKSGLEDHYDLKMLCHLILSLLADKCPSAVLAVLDSLVEPLHKTISFKPKQDAVKQEHDRNEDMIRSALRAISSLDRINGVDYSHKFKGLMGDMKRSVPLWEKFQTIRNE
Protein: MFS-type transporter patC (Patulin biosynthesis cluster protein C) (A0A075TRA9)
Organism: Penicillium expansum (Blue mold rot fungus)
Function: MFS-type transporter; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria. May be involved in the secretion of E-ascladiol to be converted to patulin by the secreted patulin synthase patE (Probable).
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:30680886}; Multi-pass membrane protein {ECO:0000269|PubMed:30680886}. Cell membrane {ECO:0000269|PubMed:30680886}; Multi-pass membrane protein {ECO:0000269|PubMed:30680886}.
Interaction partners:
Sequence:
MSIDASPSESVLESQTPDRVDESIPIKAEETEKDAAPGRDIVGFRWLLVCIAVFSANLLYGLDNTIVADIQAPIAGDFNEYTRLGWLGVGFTLGSVVFILPLGKAYAIFDTKWLFLGCLTMFAAGSALCGAAPSMNAIIVGRVWAGAGGAGMYLGNLNLITILTTPKEQPVYVGLVGLIYGTGCILGPIIGGAFSDSSATWRWSFYLNLVIFGVMSPIYVFLLPSLPRPAGEGRSFFKKLVELDWVGTVLSAGMHISIILFIVFGGVEWSWTDGRNIALYVVSAVLTIAFVLSQYFCIGTTKQDRLFPGEFLRDPTMLLLYIIMACGGAALFVAVYYIPLYFQFVHGDSGIMSAVRLLPFVCFYVATILLCGYVMPKTGYFIIWYLMSGVFMLIGAVLMYTVKLDTSPSNVYGYSILMGLGMTTTQAAYAVGPAIVTPDRVAECLQFMNIGQGQSQLLGLAIASAIFQTKTLSGLTALLGDKGYSQVDIQSAVAGAQSTLMERLPPALKTAALKVIVSSISDVYVMAISAGALYVVASCLLPRRRF
Protein: Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform (AtB' delta) (PP2A, B' subunit, delta isoform) (Q9ZQY6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26517938}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine protein phosphatase 2A regulatory subunit B''beta
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''epsilon
- Serine/threonine protein phosphatase 2A regulatory subunit B''alpha
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''delta
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''gamma
Sequence:
MFKQILGKLPKKTSAKFWDNGESQTLDNNNNQGGGDEVLSQRTSSNGDTSLDCVSSFDVLPRLRDVSISEKQELFLKKLRLCCLVFDFVAEPQQNFKEKEIKRQTLLEVVDYVISSGNGKFPESVIQEATKMISANLFSNPHRQWKNKTPEALDLEEEEGSLNPSWPHLQIVYEFLLRIVASPNTDPKISKKYIDHTFVLKLLDLFDSEDPREREYLKTILHRIYGRFMVHRPFIRKTMNNILYDFIFETGKHSGIAEFLEVLGSIINGFALPLKEEHKLFLTRVLIPLHKLKCLPNYHQQLSYCVIQFVEKDCKLADTVIRGMLKYWPVTNSAKEIMFLNELEEILEATQLTEFERCMVPLSRQIAQCLSSSHFQVAERALYLWNNDHVTNLVRQNSRIILPIVFPALEKNGSSHWNQAVKNLTENVLKVLSDTNPDLFEECLHKFQEDQQKAEDTKKKNGETWRQLEEIVASMAK
Protein: Copper transport protein ctr6 (Copper transporter 6) (Q9USV7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:12244050}; Multi-pass membrane protein {ECO:0000269|PubMed:12244050}.
Interaction partners:
- Copper transport protein ctr5
- Metal-binding regulatory protein cuf1
- Uncharacterized transporter mfc1
- Cytochrome c oxidase copper chaperone
- Copper transport protein ctr4
- Copper-binding regulatory protein cuf2
- Copper-transporting ATPase ccc2
- Copper amine oxidase 1
- Metal homeostasis factor atx1
Sequence:
MNHGGNSTMRHCSMKMTFNTDYDNLCIVFKSWHIGNLSQFLLSLLAIAILGYLFERLRSFTSLKETEFQRGYAGQQSEGLLTHHSKSLKSGRPFRLCALYAVQLVFSYFLMLVAMTYNAYVILAIAIGAAFGYRRSHCDTVQTVGLCH
Protein: Transient receptor ion channel domain-containing protein (G3MTY7)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTPLMLACILNNFSIVQCLITRGHCIQIPHFITCECKTCKRETVTTHSSTRLVDVMRALSSEAYLWLATDDVFAATCAVARDLQQLASDDQLEYVETYRDLEMNVQRFLCRISDQAWRVDEFNMMVANRNYCPERMTEISSPRLQMAMDSQMRQFTCSTNSQTTIKSVFRSDWYNYGIKPKRDAWRFLRACILMPFLVMLHAFMPTKGTTMCVPLARFIAHITMYLVFLIAAILRPTIGFYFAWTDSIEVTVQALEIFMYAYVMGLALEKGILFYRVGRDGFFAFWWRWFDAALIFIFLFSLIFFTGKWGKREAFDPSSVDRMHWPSFEFSLLHEICLAIACVLSILKCFYYAQMMKSIGGSVISVGKCVGKTYTYILIMVAIIVSFSVGLNIIVDPYLNRSTMKIGDQDYTKTTDSYETIGTSSKNLFWSIFGYLGPSTFTTVVGNTGPNMDPVKHTLNSSTFEILAAVYHGILIITVLNLMTSILVKGADEVLDNEEMEFKFTRAAIYSEFLSWEMAAPPPLNLILVVAHFVHRNLLKRYYASPAWGEKPANDDVEDQAADEQYMQLLMVVFARFVASKECKYKSIWRSEFHREEKQPPRVTFLTTGAHSFLMDNTFEGFKMRSSRTMEAEGYKEYTTVQYYVPKSKTPGPAAAADAGTKVAPKDDKPQNNPVLARTGIDSPVPSSKQVMSSELSASIPRARDVTFLGV
Protein: Secretory carrier-associated membrane protein 5 (Secretory carrier membrane protein 5) (Q9JKE3)
Organism: Rattus norvegicus (Rat)
Function: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHLSLTKRLYYLWMLNSVTLAVNLVGCLAWLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISIIQAVGIPGWGVCGWIATISFFGTNIGSAVVMLIPTVMFTVVAVFSFIALSMVHKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSTTPNYTYSNEM
Protein: FRAS1-related extracellular matrix protein 3 (NV domain-containing protein 2) (Q5H8B9)
Organism: Mus musculus (Mouse)
Function: Extracellular matrix protein which may play a role in cell adhesion.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
Sequence:
MAGDSLSLPGMSLQLLVTLTCLLLTCALRERVPLSENVSHCELYLPPWGALNGGSHQNPGILIANSGFQVPQGRSVWLNPLRDLVIRVQRGDQCKVTVLDFPRLQGALSPHQFPCDFGAQQVKYTHFGSPSSTRTRIQLQVRYDAGNSTLVLPFTLQVNVVFPKLQLVARNRPLKVFKVLGCSHAIDRRVLNFASRSRCRLTVLPHPGGPLPKYGLLVDTAGNPLSRGHLADCEAFIQAGVRYQHTTTPSSPSRDYVPMLVELLGPESQGTRSVEVLAQEYFQIQVRIQKRARSTAPIPSLAALMIVEVEQSLLTALTPDVLAAEDSESDPDDLVFNILNVPEAPPGHHGGQGYVVNTDDPLGLPVSFFTQKELRELKIAYRPPTGSSEGDHVFQLKLQVVDEDGDTSEPFAFMVVVKSMNVLAPIASYRGGLVVFEGQARPLSDALSFQVSDKDNSKEIKIVAVRGLQHGQLVVHGAPAGCKNFTLADLSAGRVVYQHDGSDSYSDNIILKMEGEHHRVDFLFPITIVPVDDAAPVLTANMGLSVTEGQVVQISPFVLCATDIDSEDSAILFVLEDEHLEGKEEETHEDLAPGSYSSSQHPGNMLLRQAEPPSSLLYSDWHYVEKEGLYETVVTEWLQRDIMEGRLFFSHPGPHSPSPVAHLAFHVQDDQDPPNLSNQHFFTISIQPADTSQPQLSPETTLEMTVQGYQLTPFQQKYLQYTDQNSDEQNLWYTLLTRPTDADSNHQVQAGEIVLTDSPGRPIVHFTQTQVNHQKIAYRPPQRNLGIVPRVVQFTYKVEDTAGNSVSGTFTVFLQPLNNQPPKVINRGFAVLEGDSFILGRGELNVSDPDTNDDQIFFILVWGPQHGHLQYFKKYMVPGESFMLADVINGSISYQNSRDQTDSDVIYLEVSDGVHHIPITVQVSVQPTVADRSPGISITGTPVLATSLTVLENAASEITMDVTHGRKNTNDLMLSFIVEDKPKLGMILVNGWPAEQVTQEDLLGGAVSYVHTSGEIGFQRVHDTFSFILSKDAYHRAMRDNILERVLVEVTVLPVDNMAPKVLVRKPFIVYEGGKNLLTPQHVNIEDVDTSKDEILCTLTVQPSSGYLENLAPAPGSEVSRAGNPISAFFVKDVRVGCINYVQSIHKGIEPGADQFTFYCSDGINFSPKVLLPLTILPTNDEQPQLFTREFVVLEGMSRVIDTSLVNGVDADFPSDKHFRLTVFPQHGQITQQLATGSKPIHSFTLQEIQEPSSIAYEHDDSESTEDSFEVWLSDGRHTTHTTVPIAVILVDDEVPQLTINDGLEIETGHSEIITNHILKAIDLDSDNKSLSFVLHSEPQQGLLQRLRKPGGDAKHNLTVGMNFTQDEIDRGLIHYIHTGQGEAVDLKFDVTDGVNTLRDRYFYITIDNSNSAVPEIVSKRVTLTEGNRMTLTTELLNTSDIHSPGEQLLYSITRAPSTGHLESSDQPGEPMASFTQLQLARNKISYVHISNDKIKLDHFELRVTGGHHSESRIFRIFVTEQDNKKPTLTIQALALQRGDNIVVTPSQLTVEDEDTPADFILFTITQIPIHGRILYNGSRPVTTFTKKDLTKSLIYCHDGSETSKDSFSFTVTDGIHTGFYVFPDTSLETHVPQTVWIQISPFDDRLPQMGINRGATALKLLHTGHLGFLITNEYLQATHQGVPHRLLTYKVTRGPEHGYIVNAGLGNENTHMFTQADIDEMRVYYILNKGRGRATRDTFYFSVETRGGKQLRNQPFHLNWAWISLEKEYYIVDEDSPFFEVTLRRGYLGGTSVVSIGTKGDTAEENKDFKGKAPMLVQFSPGQSTATWRVGLIPDTKYETSETFQIILSEPGAAALEFPEMATVEIVDPEDESTVYIPEAEYQLAEAVGEFLVPVRRSGDTSQELTVICSTRPGSATGTIPSVQLSLSDYVSRPEDNTSMLHFEKDESEKTCQVLIINDSLYEEEESFSIALSLPTGGQLGAKFPTARVTILADREDEPALHFECSEYHAEESAGYVEVAVWRRGTGLSQASSVIVRSRGTEEQAAEAGTDYIGVRQHLHFSPGVSVQRLRVTILDDLPQPAFEGPEMFELLLQMPTGAVIGEPNKTTVTINDSVTNCEECV
Protein: Nascent polypeptide-associated complex subunit alpha-like protein 4 (NAC-alpha-like protein 4) (Alpha-NAC-like protein 4) (Q9SZY1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May promote appropriate targeting of ribosome-nascent polypeptide complexes.
Interaction partners:
- Nascent polypeptide-associated complex subunit beta
- Basic transcription factor 3
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein eL42z/eL42y
- Probable elongation factor 1-gamma 2
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein eL24z
- Large ribosomal subunit protein uL23z
Sequence:
MPGPVIEEVNEEALMDAIKEQMKLQKENDVVVEDVKDGDEDDDDVDDDDDEIADGAGENEASKQSRSEKKSRKAMLKLGMKPVTDVSRVTIKRSKNVLFVISKPDVFKSPNSETYVIFGEAKIDDMSSQLQAQAAQRFKMPDVASMIPNTDGSEAATVAQEEEDDEDVDETGVEAKDIDLVMTQAGVSRPKAVKALKESNGDIVSAIMELTT
Protein: Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) (Q96F86)
Organism: Homo sapiens (Human)
Function: Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:16364915}. Note=Processing bodies (PB).
Interaction partners:
- mRNA-decapping enzyme 1A
- m7GpppN-mRNA hydrolase
- Probable ATP-dependent RNA helicase DDX6
- Protein PAT1 homolog 1
- 5'-3' exoribonuclease 1
- Enhancer of mRNA-decapping protein 4
- mRNA-decapping enzyme 1B
- Protein LSM14 homolog A
- U6 snRNA-associated Sm-like protein LSm1
- U6 snRNA-associated Sm-like protein LSm4
Sequence:
MATDWLGSIVSINCGDSLGVYQGRVSAVDQVSQTISLTRPFHNGVKCLVPEVTFRAGDITELKILEIPGPGDNQHFGDLHQTELGPSGAGCQVGINQNGTGKFVKKPASSSSAPQNIPKRTDVKSQDVAVSPQQQQCSKSYVDRHMESLSQSKSFRRRHNSWSSSSRHPNQATPKKSGLKNGQMKNKDDECFGDDIEEIPDTDFDFEGNLALFDKAAVFEEIDTYERRSGTRSRGIPNERPTRYRHDENILESEPIVYRRIIVPHNVSKEFCTDSGLVVPSISYELHKKLLSVAEKHGLTLERRLEMTGVCASQMALTLLGGPNRLNPKNVHQRPTVALLCGPHVKGAQGISCGRHLANHDVQVILFLPNFVKMLESITNELSLFSKTQGQQVSSLKDLPTSPVDLVINCLDCPENVFLRDQPWYKAAVAWANQNRAPVLSIDPPVHEVEQGIDAKWSLALGLPLPLGEHAGRIYLCDIGIPQQVFQEVGINYHSPFGCKFVIPLHSA
Protein: Zic family member4 (Q08BV0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTAEPRLGPSPFGPEHMGHSAALKISPTHHYPHHHHHHNHHIAGHSEVVSSQTGAFGPVQAATVPYSMSHTAQALSAGRDFLIRRDLTAQAMPVLTDQTSGSASHHGMFVSTTGSYPGHYGHHPDPGNHTLFPGLHHDQPSTGAPGGQALNGQIRLGIPAEMYVRSDHLSQVASSRADPFAASPLHGYGGLNLNMNLSAHHHHGAGAFFRYMRQPIKQELICKWLEPEHSAKKLCSKTYSTMHELVTHVTVEHVGGPEQANHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRRFANSSDRKKHSHVHTSDKPYNCKVRGCDKSYTHPSSLRKHMKVHCKSPPPSSGYESSTPSLVSPSSDLGREPAPSALSEPLSSSSQPANLSEWYVCHSSGASGPQTPPSGSSTPGHTEGPTYGNPERRDAF
Protein: Steroid transmembrane transporter SLC22A24 (Solute carrier family 22 member 24) (Q8N4F4)
Organism: Homo sapiens (Human)
Function: Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids including estradiol-17beta-D-glucuronide (or 17beta-estradiol 17-O-(beta-D-glucuronate)), androstanediol glucuronide (or 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), and estrone 3-sulfate, as well as bile acids taurocholate and glycocholate, driven by an outward gradient of dicarboxylates such as glutarate or succinate.
Subcellular location: [Isoform 1]: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:31553721}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:31553721}.
Interaction partners:
Sequence:
MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENDRKDSRNIKQEDTCMKVTQF
Protein: Ubiquitin-like modifier-activating enzyme atg7 (ATG12-activating enzyme E1 atg7) (Autophagy-related protein 7) (AtAPG7) (Protein PEROXISOME UNUSUAL POSITIONING 4) (Q94CD5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process. Involved in the degradation of damaged peroxisomes. Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing.
Interaction partners:
- Autophagy-related protein 8h
- Autophagy-related protein 8e
- Ubiquitin-like protein ATG12B
- Autophagy-related protein 3
- Ubiquitin-like protein ATG12A
- Autophagy-related protein 8f
- Autophagy-related protein 8a
- Autophagy-related protein 8g
- Autophagy-related protein 8i
- Autophagy-related protein 8d
Sequence:
MAEKETPAIILQFAPLNSSVDEGFWHSFSSLKLDKLGIDDSPISITGFYGPCGHPQVSNHLTLLSESLPLDEQSLIASTSHGNRNKCPVPGILYNTNTVESFNKLDKQSLLKAEANKIWEDIQSGKALEDPSVLPRFLVISFADLKKWSFRYWFAFPAFVLDPPVSLIELKPASEYFSSEEAESVSAACNDWRDSDLTTDVPFFLVSVSSDSKASIRHLKDLEACQGDHQKLLFGFYDPCHLPSNPGWPLRNYLALIRSRWNLETVWFFCYRESRGFADLNLSLVGQASITLSSGESAETVPNSVGWELNKGKRVPRSISLANSMDPTRLAVSAVDLNLKLMRWRALPSLNLNVLSSVKCLLLGAGTLGCQVARTLMGWGIRNITFVDYGKVAMSNPVRQSLYNFEDCLGRGEFKAVAAVKSLKQIFPAMETSGVVMAIPMPGHPISSQEEDSVLGDCKRLSELIESHDAVFLLTDTRESRWLPSLLCANANKIAINAALGFDSYMVMRHGAGPTSLSDDMQNLDINKTNTQRLGCYFCNDVVAPQDSMTDRTLDQQCTVTRPGLAPIAGALAVELLVGVLQHPLGINAKGDNSSLSNTGNNDDSPLGILPHQIRGSVSQFSQITLLGQASNSCTACSETVISEYRERGNSFILEAINHPTYLEDLTGLTELKKAANSFNLDWEDDDTDDDDVAVDL
Protein: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2) (Q9Z2Z9)
Organism: Mus musculus (Mouse)
Function: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Interaction partners:
- Glutamine synthetase
- Glucosamine 6-phosphate N-acetyltransferase
- Glucose-6-phosphate isomerase
- N-acetylglucosamine-6-phosphate deacetylase
- Glutamine--fructose-6-phosphate aminotransferase 1
- Glucosamine-6-phosphate deaminase 1
- Mannose-6-phosphate isomerase
- Amidophosphoribosyltransferase
- Glucosamine-6-phosphate deaminase 2
- Hexokinase-2
Sequence:
MCGIFAYMNYRVPKTRKEIFETLIRGLQRLEYRGYDSAGVAIDGNNHEVKERHIHLVKKRGKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPNAVNSHPQRSDKDNEFVVIHNGIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEGAFALVFKSIHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPVLYPTCNIENVKNICKTRMKRLDSSTCLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSATDDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDHLKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLLALRYCKDRGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFISLVMFGLMMSEDRISLQNRRQEIIRGLRSLPELIKEVLSLDEKIHDLALELYTQRSLLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKQMPVIMVIMKDPCFAKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFHLAVLRGYDVDFPRNLAKSVTVE
Protein: Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ET-AR) (Q61614)
Organism: Mus musculus (Mouse)
Function: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Endothelin-3
- Endothelin-1
- Endothelin-2
- Angiotensinogen
- Endothelin receptor type B
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-13
- Kininogen-1
Sequence:
MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERSSHKDSMN
Protein: Envelope small membrane protein (E protein) (sM protein) (P59637)
Organism: Severe acute respiratory syndrome coronavirus (SARS-CoV)
Function: Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.
Subcellular location: Host endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:20861307}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-Rule:MF_04204, ECO:0000269|PubMed:21450821, ECO:0000269|PubMed:24788150}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04204}. Note=Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment (PubMed:20861307). The cytoplasmic tail functions as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04204, ECO:0000269|PubMed:20861307, ECO:0000269|PubMed:21450821}.
Interaction partners:
Sequence:
MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPTVYVYSRVKNLNSSEGVPDLLV
Protein: Protein P6 (Protein VI) (Q9XJR1)
Organism: Pseudoalteromonas phage PM2 (Bacteriophage PM2)
Subcellular location: Virion membrane {ECO:0000305|PubMed:12134022}. Note=Part of the capsid inner membrane. {ECO:0000305|PubMed:18775333}.
Interaction partners:
Sequence:
MANFLTKNFVWILAAGVGVWFYQKADNAAKTATKPIADFLAELQFLVNGSNYVKFPNAGFVLTRDALQDDFIAYDDRIKAWLGTHDRHKDFLAEILDHERRVKPVYRKLIGNIIDASTIRAASGVEL
Protein: Alpha-(1,3)-fucosyltransferase 4 (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Fucosyltransferase 4) (Fucosyltransferase IV) (Fuc-TIV) (FucT-IV) (Galactoside 3-L-fucosyltransferase) (Q11127)
Organism: Mus musculus (Mouse)
Function: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (By similarity).
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Interaction partners:
- Galactoside alpha-
- Galactoside alpha-
- E-selectin
- Type 2 lactosamine alpha-2,3-sialyltransferase
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
- Galactoside 2-alpha-L-fucosyltransferase Sec1
- Beta-1,4-galactosyltransferase 1
- Beta-1,4-galactosyltransferase 4
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
- Beta-1,4-galactosyltransferase 2
Sequence:
MAPARQELQHESRCRPSRTVDAWRAAVATRGRHMETPGYRRRTRCGGWGLPRSVSSLAAVGLLCTALTTFICWGQLPPLPWASPAPQRLVGVLLWWEPFRGRGGYPKSPPDCSLRFNISGCRLLTDRAAYGEAQAVLFHHRDLVKELHDWPPPWGARERTDKALVLRVFDDQEGAVTLTGKALETVGSRPPGQRWVWMNFESPSHTPGLRGLAKDLFNWTLSYRTDSDVFVPYGFLYSRSDPTEQPSGLGPQLARKRGLVAWVVSNWNEHQARVRYYHQLSRHVSVDVFGRTGPGRPVPAIGLLHTVARYKFYLAFENSRHVDYITEKLWRNAFLAGAVPVVLGPDRANYERFVPRGAFIHVDDFPNAASLAAYLLFLDRNVAVYRRYFRWRRSFAVHITSFWDEQWCRTCQAVQTSGDQPKSIHNLADWFQR