wanglab/gogpt-training-data huggingface dataset:
Protein: Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1) (O14576)
Organism: Homo sapiens (Human)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Subcellular location: Cytoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19229290}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19229290}.
Interaction partners:
- Cytoplasmic dynein 1 light intermediate chain 1
- Cytoplasmic dynein 1 heavy chain 1
- Dynactin subunit 2
- Dynactin subunit 1
- Dynein light chain 1, cytoplasmic
- Protein bicaudal D homolog 2
- Cytoplasmic dynein 1 light intermediate chain 2
- Dynein light chain roadblock-type 1
- Dynein light chain 2, cytoplasmic
- Cytoplasmic dynein 1 intermediate chain 2
Sequence:
MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWVYDVGELAVPHNDEWTRFARTLVEIRANRADSEEEGTVELSA
Protein: Diguanylate cyclase (Q9I594)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- cyclic-guanylate-specific phosphodiesterase
- Cyclic di-GMP phosphodiesterase RocR
- GGDEF domain-containing protein
- EAL domain-containing protein
- Sensory/regulatory protein RpfC
- cyclic-guanylate-specific phosphodiesterase
- Cyclic di-GMP phosphodiesterase PA2567
- histidine kinase
- Probable two-component response regulator
- cyclic-guanylate-specific phosphodiesterase
Sequence:
MEPSPRTAAAVKSGACLLTSTLIARLLEGWVAPDDARLPEEYAAQVTQPRRCIEMSNFNSHDRVSLCSQPAARLMLSPITRPHRMPLRTRLLWLFLPLLAASLGGIWLLSESILLSRFDREDQQRLQEGATVLHNRLDFELKRHLDIVRTYAWWDASYDFIQRPNETFEQENLDHEMLDDLGFDFVLFLDDRGHLQLKQWSPPAPDQRVLFGAPSASDQALLEALQQRAIRLGALDFRGRTDHSLSELLLVDNLPTLLVSVPISNNQGSAPAKGAILAGYFLDRERLANLREQMQADLQPMPNIATDSTWKPLRSRSGSTHNQALLSPRRFIGEHVQQVSVQYLSSSGEPQLRFDITKKRLLYIQGEKAINFFLGASLLVALGAFLVGYLALELWVLRRVQRLNREVAEVGRNAHSIRLSDFGNDELGQLAGEMNQMLERLEHSEARDRAILQSMRDGYFEMDVDGVILTVNPALCQLLGQTRETLIGHPYYELLGEDDLARARQPFQRAMQSGAGKTFAIPLQRADGSLGYFEATVSLIHDLQGELRGYRGIVRDVSDQIAYQQQLLEMAYRDPLTGLGNRKAFDEQLGQALLRAGSGGSELALLYLDLDRFKEVNDRFGHDIGDALLRTVAERVRSTLRQPDKAYRLGGDEFAVLLEDSQENNPQRLAERLLAALVQPIALNGERIDFVTPSIGIALYPRHAGDAEGLVRAADSAMYEAKRQRNHYCLYQAPA
Protein: Protostome-specific GEF, isoform G (M9PGC1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPTMTRMHRHSSSSAVVEESRGRRRGVGVPGVGDANKENFGVHFMSSPFGNASLIALQDLSNVHGKSPQRRSFSEGSGPRQATPQLAALRCLPRTTGGAVALEDSQLSSSRMGDTTLDRMLDAIIESARKEVRCTKTLPGAGATTSTTILADNAEWSETSVHEMEVRTPTHLKRQRVVRRKNPHKTTTINQTQSHQAKKLEPLQLVPSTKRCLSFSSSSASSDLDEDEQQVAKRSSLASPTTTPPSHCTTTTSSISSSSSSNGGADMEASQRGSIDVSIAFDAKEQQLNVHVIRCRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGSMSSGYQRTAVHRHSGRPYFDQRFNFQISSGEETAGQYLQLAVWHRDRHLKRSEFLGCSTFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISIDSMGKEDPLLPQQPQQPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQATGSQSSASKANESNANHLNNGTSGGRRQSTMPNSGGSSVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWTHPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIFRRSGAGATTITSTDLGQNNVHISTRLGAAVGLGSEEHTLATTATGTTTVMSLQRTTSTRIQPLANSMSRPATACSGTTSSIEAAKRRLHLPQVTFSKESIVPVTDNRRRFLLQLISREQNFTAALHFGVDRFVQPLGERKDLISPNDHRTLFQNIDELLRIAEDILEQLCSSDQQDQEPQMNFASRVYLSKTTAICAAYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAVPRKRPDLTMFIHRPLQHFREILKLMQLLAGNCHVDTEEHKNFSTVINELQAAYREITVSSGLMEPLGEGRPLLTLQDLESRMVFTKCKPFTLAVQGRQWIFGGDLSRVEGRSVKPYWTLLFSDIIVFAKVSRDRVLFITEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAPDLTRTPKRGARRKSLILRAPSLELKAVWQNLLQRQIFLVNAALGSTPLSSPLDSPDVLNTLVPLSDIGLTTASMGSMKLPSLDSIHLKQQQKQQRTNNSHGHVHSATGVATDRTADRSHGHNHGIHGGHVEQIELLIDEKCRILNKTGTPKSSALHLANWMKGQLDKQQQQARLAAIARSQENVSAEDEQLIFNSDSEQDERITYWTRQQLEKRTKELNLAKENGGLSARPNFGGKRLSGVEELSMSATSDIYSTSEAEGVTSVISQSHSTTSDSQITVRSSPIVLDKLAVCRHCHKNCQQSGPGGARPGGGGGVNNSSSTPVLLCNSLKVQHSQSSPNRCCKLSNGIAGATEMANPKNSNRTGTGTGSVTSMSSSTITGELSSKVVASSSRRETGDTESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSLPNGHCSAGVGGGSPKPLPPPRRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGGSPAKYAACHCRCTPEDFTHAQLSPDKMEHQTCKLLESPKQTTTTLEQKQEDEQLSLMLIGLAQLAPAATLCGQERIPKEENSTPTIAVVPPTPDSVLTKTSTHVWDNSGCSSNGGGTSTTSTATTTTKQPRQAIIENIPEDSCDESPLDEEPPYRPMSSALRRFGTMSSLEKLPSDDRMDEADELDDDLDSFKPNGHDGNSPQNEEDDEDADSERALVQNDLGASSSSGVIVNGEGLASGAWTNRAGAYVSDKMSFFEESRAFIDKYLGRWNAGDAQQQHQQGTASETDEQMDECTSGATSGEEVWGTPTSGGDNDDQDLQLINSENTHSSPTKSSTSLNDDDDTELMMDELLMAPPMTASTIRGLLPRRRLEPLFEEETESDEEKTQQDSDDIKKKVVVKLVKL
Protein: Ubiquitin-conjugating enzyme E2 6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 6) (Ubiquitin carrier protein UBC6) (Ubiquitin-protein ligase UBC6) (P33296)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8396728}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 7
- ERAD-associated E3 ubiquitin-protein ligase DOA10
- Holocytochrome-c synthase
- ERAD-associated E3 ubiquitin-protein ligase HRD1
- Alpha-1,2-mannosyltransferase ALG9
- Transcription factor tau 95 kDa subunit
- Coupling of ubiquitin conjugation to ER degradation protein 1
- SAGA complex/transcription factor TFIID complex subunit TAF10
- E3 ubiquitin-protein ligase RSP5
- Protein transport protein SEC61
Sequence:
MATKQAHKRLTKEYKLMVENPPPYILARPNEDNILEWHYIITGPADTPYKGGQYHGTLTFPSDYPYKPPAIRMITPNGRFKPNTRLCLSMSDYHPDTWNPGWSVSTILNGLLSFMTSDEATTGSITTSDHQKKTLARNSISYNTFQNVRFKLIFPEVVQENVETLEKRKLDEGDAANTGDETEDPFTKAAKEKVISLEEILDPEDRIRAEQALRQSENNSKKDGKEPNDSSSMVYIGIAIFLFLVGLFMK
Protein: General transcription factor IIH subunit (Q9VNP8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR015919}.
Interaction partners:
- General transcription factor IIH subunit 4
- General transcription and DNA repair factor IIH helicase subunit XPD
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIH subunit 3
- General transcription factor IIH subunit 1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- Cyclin-H
- General transcription factor IIE subunit 1
- Transcription initiation factor IIE subunit beta
- Cyclin-dependent kinase 7
Sequence:
MADDEQEDQKEYRWETGYEKTWEAIKDDEDGMLDGAIAEIIQKAKRQRQAQKSKQNRLGMMRHMFVVLDCSESMSVPDLKPTRLRCTVKLLELFIEEFFDQNPISQLGLIALKAKRAEKVTELTGTSRVHLKALESLANVSLTSEPSLQNGLDLALKSLKVVPSHASREIVIIMGSLTTCDPVDINLTIDELKKEGIRCSVISLSAEIHVARYLTQQTMGTFGAVLDDAHFRDQLMSQVDPPPAAKTQHNSLIRMGFPHTKNEVEGKDAPLSMCMCHIENLEEPSELTTTGHHCPQCNSKYCELPVECQSCGLTLVSAPHLARSYHHLFPVPNFEELPFEAMPASSSDLTSDVRECYGCAKALGQGVDKVADKVVFRCGFCKQFFCVDCDIFIHDTLHACVGCNTIPGVDGLVYQQSSKSDQVDAHPGPSKQRGQCGM
Protein: Histone H3.X (Histone H3.Y2) (P0DPK5)
Organism: Homo sapiens (Human)
Function: Primate-specific variant histone H3, which constitutes a core component of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (Probable).
Subcellular location: Nucleus {ECO:0000269|PubMed:20819935}. Chromosome {ECO:0000305|PubMed:20819935}.
Interaction partners:
- Cytokine-like nuclear factor N-PAC
Sequence:
MARTKQTARKATAWQAPRKPLATKAARKRASPTGGIKKPHRYKPGTLALREIRKYQKSTQLLLRKLPFQRLVREIAQAISPDLRFQSAAIGALQEASEAYLVQLFEDTNLCAIHARRVTIMPRDMQLARRLRGEGAGEPTLLGNLAL
Protein: Co-chaperone protein SBA1 (P28707)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a co-chaperone.
Interaction partners:
- ATP-dependent molecular chaperone HSC82
- ATP-dependent molecular chaperone HSP82
- Peptidyl-prolyl cis-trans isomerase CPR6
- Hsp90 co-chaperone AHA1
- Hsp90 co-chaperone Cdc37
- Hsp90 co-chaperone HCH1
- Heat shock protein STI1
- Peptidyl-prolyl cis-trans isomerase CYP7
- Serine/threonine-protein phosphatase T
- Cell division control protein 48
Sequence:
MSDKVINPQVAWAQRSSTTDPERNYVLITVSIADCDAPELTIKPSYIELKAQSKPHVGDENVHHYQLHIDLYKEIIPEKTMHKVANGQHYFLKLYKKDLESEYWPRLTKEKVKYPYIKTDFDKWVDEDEQDEVEAEGNDAAQGMDFSQMMGGAGGAGGAGGMDFSQMMGGAGGAGSPDMAQLQQLLAQSGGNLDMGDFKENDEEDEEEEIEPEVKA
Protein: PRADC1-like protein (PAP21-like protein) (Q9W1W9)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in iversification of muscle cell fates.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9BSG0}.
Interaction partners:
Sequence:
MLIAWLVLAATLSRSIRASTTISIPITTQDIIAGDVFFEILSPSELEYTYRLRPAKDFGSAFSERLEGVPLVITDPPGACQEIRNARDLNGGVALIDRGECSFLTKTLRAEAAGALAAIITEYNPSSPEFEHYIEMIHDNSQQDANIPAGFLLGKNGVIIRSTLQRLKRVHALINIPVNLTFTPPSKINHPPWLGW
Protein: Zinc finger CCCH-type with G patch domain-containing protein (A0A0S2Z5X3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAVEAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPCPFFLEGKCRFKENCRFSHGQVVSLDELRPFQDPDLSSLQAGSACLAKHQDGLWHAARITDVDNGYYTVKFDSLLLREAVVEGDGILPPLRTEATESDSDSDGTGDSSYARVVGSDAVDSGTCSSAFAGWEVHTRGIGSRLLTKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLDQCVETLQKQTRVGKAGTNKPPRCRGRGARPGGRPAPRNVFDFLNEKLQGQAPGALEAGAAPAGRRSKDMYHASKSAKRALSLRLFQTEEKIERTQRDIRSIQEALARNAGRHSVASAQLQEKLAGAQRQLGQLRAQEAGLQQEQRKADTHKKMTEF
Protein: Guanylyl cyclase-activating protein 1 (Guanylate cyclase activator 1A) (Q6PFM5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGDSSSMSATELSACKCHQWYRKFMTECPSGQLTFYEFKKFFGLKNLSEKSNAYVNTMFKTFDIDDDGCIDFMEYVAALSLVLKGGVQQKLRWYFKLFDMDGSGCIDKDELLLIFKAVQAINGAEPEISAEDLADMVFNKIDVNGDGELSLEEFMEGISADEKISEMLTQSLDLTRIVSNIYNDSYIEQEAEIIEDQA
Protein: Carboxylic ester hydrolase (EC 3.1.1.-) (A0A8J8XQI9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
LQTQHTMVTEIHFLLWILLLCMLFGKSHTEEDVIITTKTGRVRGLSMPILGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFPGNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCSKENEKEIITCLRSKDPQEILLNEKLVLPSDSIRSINFGPTVDGDFLTDMPHTLLQLGKVKTAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRREFQEGLNMYFPGVSSLGKEAILFYYVDWLGDQTPEVYREAFDDIIGDYNIICPALEFTKKFAELEINAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQGNSTVWPVFTSTEQKYLTLNTEKSKINSKLRAPQCQFWRLFFPKVLEITGDIDEREQEWKAGFHRWSNYMMDWKNQFNDYTSKKETCTDL
Protein: Negative elongation factor E (A0A8J8XR86)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVTVENDVLGSALEPGANMLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSGTASQGGVKRSLSEQPVVDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSMSADEDLQEPSRRPQRKSLYESFVSSSDRLRELGQDGEEAEAPGAGEGPPRGFDWSYEEHSGARSSASPPRSRSRDRSHDRSRDRDRDKERDRDRDRDRERDKDKDRDRDRDRDKERDRDRDRERDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDL
Protein: Paired box protein Pax-1 (HuP48) (P15863)
Organism: Homo sapiens (Human)
Function: This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein MOX-1
- Zinc finger protein 582
- Protein phosphatase EYA1
- Basic helix-loop-helix transcription factor scleraxis
Sequence:
MKFTLGLGSRAWRVSWEGAAAAAAGPGAGGSALRCRAQRVSSPRLGRRGSRLSGALPLCLSRGGGGAQALPDCAGPSPGHPGHPGARQLAGPLAMEQTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSLAQPGPYEASKQPPSQPTLPYNHIYQYPYPSPVSPTGAKMGSHPGVPGTAGHVSIPRSWPSAHSVSNILGIRTFMEQTGALAGSEGTAYSPKMEDWAGVNRTAFPATPAVNGLEKPALEADIKYTQSASTLSAVGGFLPACAYPASNQHGVYSAPGGGYLAPGPPWPPAQGPPLAPPGAGVAVHGGELAAAMTFKHPSREGSLPAPAARPRTPSVAYTDCPSRPRPPRGSSPRTRARRERQADPGAQVCAAAPAIGTGRIGGLAEEEASAGPRGARPASPQAQPCLWPDPPHFLYWSGFLGFSELGF
Protein: Synaptobrevin (P18489)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9W0C1}; Single-pass type IV membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27323327}; Single-pass type IV membrane protein {ECO:0000255}. Note=Neuronal synaptic vesicles (By similarity). In embryos, expressed in the plasma membrane of tracheal cells (PubMed:27323327). {ECO:0000250|UniProtKB:P63027, ECO:0000269|PubMed:27323327}.
Interaction partners:
- Syntaxin-1A
- Synaptosomal-associated protein 25
- Synaptosomal-associated protein
- Alpha-soluble NSF attachment protein
- Synaptotagmin 1
- LD27967p
- Complexin
- Unc-13, isoform E
- Syntaxin-5
- Syntaxin-4
Sequence:
MENNEAPSPSGSNNNDFPILPPPPNANDNYNQFGDHQIRNNNAAQKKLQQTQAKVDEVVGIMRVNVEKVLERDQKLSELGERADQLEQGASQFEQQAGKLKRKQWWANMKMMIILGVIAVVLLIIVLVSVWPSSSDSGSGGGNKAITQAPPH
Protein: Anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase (EC 2.4.1.297) (3-O-glucoside-2''-O-glucosyltransferase) (In3GGT) (Protein dusky) (Dy) (Q53UH4)
Organism: Ipomoea nil (Japanese morning glory) (Pharbitis nil)
Function: Glycosyltransferase that mediates the glucosylation of anthocyanidin 3-O-glucosides to yield anthocyanidin 3-O-sophorosides. 3-O-sophoroside derivatives are required for the bright blue or red color of flowers.
Interaction partners:
Sequence:
MGSQATTYHMAMYPWFGVGHLTGFFRLANKLAGKGHRISFLIPKNTQSKLESFNLHPHLISFVPIVVPSIPGLPPGAETTSDVPFPSTHLLMEAMDKTQNDIEIILKDLKVDVVFYDFTHWLPSLARKIGIKSVFYSTISPLMHGYALSPERRVVGKQLTEADMMKAPASFPDPSIKLHAHEARGFTARTVMKFGGDITFFDRIFTAVSESDGLAYSTCREIEGQFCDYIETQFQKPVLLAGPALPVPSKSTMEQKWSDWLGKFKEGSVIYCAFGSECTLRKDKFQELLWGLELTGMPFFAALKPPFEAESIEAAIPEELKEKIQGRGIVHGEWVQQQLFLQHPSVGCFVSHCGWASLSEALVNDCQIVLLPQVGDQIINARIMSVSLKVGVEVEKGEEDGVFSRESVCKAVKAVMDEKSEIGREVRGNHDKLRGFLLNADLDSKYMDSFNQKLQDLLG
Protein: Zinc finger protein 415 (Q09FC8)
Organism: Homo sapiens (Human)
Function: Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53.
Subcellular location: Nucleus {ECO:0000269|PubMed:17055453}. Cytoplasm {ECO:0000269|PubMed:17055453}. Note=Isoforms 1, isoform 2, isoform 4 and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3 localized only to nucleus.
Interaction partners:
Sequence:
MPELYTEDFIQGCDVGELQEPGLPGVLSYVGAQERALDHRKPSTSSKKTKRVEIDQRCENRLECNGAISAHCNLRLPDSNDSPASASRVAGITDLSRNCVIKELAPQQEGNPGEVFHTVTLEQHEKHDIEEFCFREIKKKIHDFDCQWRDDERNCNKVTTAPKENLTCRRDQRDRRGIGNKSIKHQLGLSFLPHPHELQQFQAEGKIYECNHVEKSVNHGSSVSPPQIISSTIKTHVSNKYGTDFICSSLLTQEQKSCIREKPYRYIECDKALNHGSHMTVRQVSHSGEKGYKCDLCGKVFSQKSNLARHWRVHTGEKPYKCNECDRSFSRNSCLALHRRVHTGEKPYKCYECDKVFSRNSCLALHQKTHIGEKPYTCKECGKAFSVRSTLTNHQVIHSGKKPYKCNECGKVFSQTSSLATHQRIHTGEKPYKCNECGKVFSQTSSLARHWRIHTGEKPYKCNECGKVFSYNSHLASHRRVHTGEKPYKCNECGKAFSVHSNLTTHQVIHTGEKPYKCNQCGKGFSVHSSLTTHQVIHTGEKPYKCNECGKSFSVRPNLTRHQIIHTGKKPYKCSDCGKSFSVRPNLFRHQIIHTKEKPYKRN
Protein: Secretory carrier-associated membrane protein (Secretory carrier membrane protein) (Q9NHD7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363122}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363122}.
Interaction partners:
Sequence:
MSGSGLDENPFGEPNLDNPFADPAIQQARRLQSGAALVSLEDYNPFEEQAKPQLQINSTNTAAVVQPLSQNIPPPQTSSLGASAPSTSIQITSEELQRRQEELDRKAAELDRREQQLQGNVPQLNNWPPLPDNFCVKPCFYQDFEVEIPPEFQKLVKRLYYIWIFYTMTLLANVIGGLIFWFHAGEFETFFLAIFYTMLFSPASYVCWFRPAYKAFRNDSSFNFMVFFFIYFFQTLYSIVQAVGFNKMGYCGFITAIGQFDGQASGIIVGILLLNVAFCFTAVAVANVLMITKIHSIYRSTGASMAKAQAEFTTEFLRNQHVQEAASSAVNTAINSQFNNSRY
Protein: RNA polymerase sigma-54 factor RpoN (Q74BZ1)
Organism: Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Interaction partners:
- Sigma-54-dependent transcriptional response regulator PilR
- HAD superfamily hydrolase
- histidine kinase
- DNA-directed RNA polymerase subunit alpha
- DNA-binding transcriptional regulator NtrC)
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit omega
- RNA polymerase sigma factor SigA
- Ribosome hibernation promoting factor
Sequence:
MAIEMRQQMKMTQQLVMTPQLQQAIKLLQLSRLELQDLVRQEMEENPLLEESQEAEEVKEQDLVELSEKEDAPAPAEQDFREVTTGEETRESDWDSYLEGYNYSSGEQYYDDEDRPSYENILTRKGTLADHLMWQLNMTKLSDEEARASAEIIGNIDEDGYLRATVEEVALACSVSESVAESALKKIQEFDPMGVGARSLRECLLIQVEQLGMAGSVVDGILRNHLHDLETRKYKQIAKSLGVDVDSILMAAKIIAGLDPKPGRVYGSEDVHYISADIFVYKIADDYVVVLNDEGLPNLRISPFYAGEIKNGAAVDAKAEEYINEKSRSAMWLIKSIHQRQRTIYKVAKSIVKFQREFLDRGIEHLRPLVLRDVAEDIGMHESTISRVTTNKYMQTPQGLFEMKYFFNSGISTTEGDFIASESVKNKIKEIVDSEDPRKPYSDQRIAELLSAHTINIARRTVTKYREMLKIGSSSERKRHF
Protein: Ras-related protein Rac2 (P48554)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Rho GDP-dissociation inhibitor 3
- non-specific serine/threonine protein kinase
- Stress-activated protein kinase JNK
- Trio, isoform A
- non-specific serine/threonine protein kinase
- Mitogen-activated protein kinase kinase kinase
- Myoblast city, isoform B
- Ras-related protein Rac1
- RE12101p
- Protein vav
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDAKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRAKWFPEVRHHCPSVPIILVGTKLDLRDDKQTIEKLKDKKLTPITYPQGLAMAKEIAAVKYLECSALTQKGLKTVFDEAIRSVLCPVVRGPKRHKCALL
Protein: BCL-6 corepressor (H7BYY2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLNINGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLYSPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTPSASPAIPPLVHCADKSLPWKMGVSPGNPVDSHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTYSEFHKHYARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDVDASKADHMKKMAPTVLVHSRAGSGLVLSGSEIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQRSSSCPRMGGTDAVITNVSGSVSSAGRPASASPAPNANADGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEPSFKANENGLPPSSIFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVVKSDKLVYVDLLREEPDAKTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALREELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPFLEPPLGSDGPAVTFGKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAYCERAMMRFSELEMKEREGGHPATKDSEMCKFSPADWERLKGNQDKKPKSVTLEEAIAEQNESERCEYSVGNKHRDPFEAPEDKDLPVEKYFVERQPVSEPPADQVASDMPHSPTLRVDRKRKVSGDSSHTETTAEEVPEDPLLKAKRRRVSKGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSEESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQ
Protein: E23 (Q9GZ10)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPMNLMIVESVEAVDMGSSDNDNETTEQVPLVSASRRNLAKIVADCRLQIEVEPATSAVAAAAAAAASVASPPATSDATAATSVASSDSSASSSASSTSSSSSSSSSTSSEFTHTSQTTIPSTDNLTSSNGLANIGKSILVDAKSNSPASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHIDSGSVFLNREPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNSYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQLCVLSSRNFREAKPRMLSKLNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSFPSEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCTSLKLFFLMLIFLLINTIVAQSVGFFIGACCMDMNVSITLSALYTLATQLFGGYLSSRIPEGLSWIRYTSMIHYAYQNMQLLEFSEGAAIGCGSPSSYEICKQQSTEFIPYEEILKAQNSTSPLWLNTLILMMFFLVFRCLGYAVLRFLRCPKKT
Protein: Ubiquitin-like-specific protease ESD4 (EC 3.4.22.68) (Protein EARLY IN SHORT DAYS 4) (AtESD4) (Q94F30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins. Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5. Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3. Acts predominantly as an isopeptidase, cleaving SUMO-conjugated proteins better than SUMO peptides. Plays an important role in the control of flowering time.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:14507998, ECO:0000269|PubMed:17513499}; Peripheral membrane protein {ECO:0000269|PubMed:14507998, ECO:0000269|PubMed:17513499}. Note=The nuclear envelope localization is independent of the presence of the nuclear pore anchor NUA.
Interaction partners:
- Small ubiquitin-related modifier 1
- Small ubiquitin-related modifier 2
- Small ubiquitin-related modifier 3
- Small ubiquitin-related modifier 5
- Putative small ubiquitin-related modifier 7
- Putative small ubiquitin-related modifier 4
- SUMO-conjugating enzyme SCE1
- Putative small ubiquitin-related modifier 8
- Putative small ubiquitin-related modifier 6
- E3 SUMO-protein ligase SIZ1
Sequence:
MGAVAINRKRSDESFNFINQQSTNPLRNSPYFQASKKRRFSFAMSEDSGKPASSNPTISRISRYPDAKAPLRREIHAPSRGILRYGKAKSNDYCEKDANFFVRKYDDAKRSALEALRFVNKGKDFVDLGDEVEKEEVVSDDSSVQAIEVIDCDDDEEKKNLQPSFSSGVTDVKKGENFRVEDTSMMLDSLSLDRDVDNDASSLEAYRKLMQSAEKRNSKLEALGFEIVLNEKKLSLLRQSRPKTVEKRVEVPREPFIPLTEDEEAEVYRAFSGRNRRKVLATHENSNIDITGEVLQCLTPSAWLNDEVINVYLELLKERETREPKKYLKCHYFNTFFYKKLVSDSGYNFKAVRRWTTQRKLGYALIDCDMIFVPIHRGVHWTLAVINNRESKLLYLDSLNGVDPMILNALAKYMGDEANEKSGKKIDANSWDMEFVEDLPQQKNGYDCGMFMLKYIDFFSRGLGLCFSQEHMPYFRLRTAKEILRLRAD