Protein: Condensin-2 complex subunit CAP-D3 (Protein CHROMOSOME-ASSOCIATED POLYPEPTIDE D-3) (AtCap-D3) (O24610)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids (By similarity). Required for plant vigor, fertility, chromatin condensation and sister chromatid cohesion both during mitosis and meiosis. Necessary to maintain normal structural integrity of the meiotic chromosomes during the two nuclear divisions of gametogenesis, especially to prevent interchromosome connections at metaphase I. Seems also involved in crossover formation during meiotic prophase I. Prevents centromeric and pericentromeric heterochromatin repeats association.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:23929493, ECO:0000269|PubMed:27385818}. Chromosome {ECO:0000269|PubMed:23929493, ECO:0000269|PubMed:25065716, ECO:0000269|PubMed:27385818}. Note=Observed throughout euchromatic nucleoplasm (PubMed:23929493, PubMed:27385818). Associates with the chromosomes throughout meiosis (PubMed:25065716). {ECO:0000269|PubMed:23929493, ECO:0000269|PubMed:25065716, ECO:0000269|PubMed:27385818}.
Interaction partners:
- Condensin-2 complex subunit H2
- ARM repeat superfamily protein
- Structural maintenance of chromosomes protein 2-1
- Structural maintenance of chromosomes protein 2-2
- Structural maintenance of chromosomes protein 4
- Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein 3
- Retinoblastoma-related protein 1
- Structural maintenance of chromosomes protein 5
- Structural maintenance of chromosomes protein 6A
Sequence:
MDEELLLTRILAGIEGGDDESDYHELVTDLKSLLDTDDDEILNRFYGSLSSMASSFLRCISAAMDSPVESGRLAILASDAYLSLLLSTNCPVFTFFSPIAFLSLLGSIRRYLKRRDDSAGQGSNSQREKGNKKKRGRGKRNLGYEDGEETEEGGFDAKLMFIVLEKLGSVLSFVHLDRFPDSLKSLVQTVSEIPLLALEHSGVLNYDRLMEMCGKILGGVLNSDHGDMALTAAEISKSLTPLLLMGKHQARSFALGFVSRKLMSLAKDNPELKKVVSNLPKFLVHKAPEKAEPRGFAVEAVLEIVKAMEVEGQSEFVDFVMKMCQGKSNFRVLAVDIIPLLISSLGNPLGDISSENGLKDSWGLGCIDALVQRCSDTSALIRARALSNLAQVVEFLSGDERSRSILKQALGFNGETSEGKGAVTDLLKKRCVDEKAAVRRAALLLVTKLTSLMGGCFDGSILKTMGTSCSDPLISIRKAAVSAISEAFRICTDEIVTTEWLHSVPRMIMDNETSIQEECENVFHELVLERILRAGNVLSPDSASLPNNRNTTSKDLDRDIEALFPEGVLVLLRELCNSEVSPWVTKICGSLGKKKRLKPRVALALQCIIKESESLWLSRSMPINRWTAPAGAWFLLSEVSVYLSKSVEWEFLHHHWQLLDKNDVQGLDEQGDEQGVECNSSTWAGDRVCLLQTISNVSLQLPAEPAADLADNLLKKIENFNLHSAEVDAHVKALKTLCKKKASTSEEADMLVKKWVEQVSLKASKVTEKYIEGVSSHNHSFVTPATLGSRRSKRLDTVSKKLSKAVTAVYTIGSCVIIYPSADTTKIVPFLHTVITSGNSDSKLKNKLPQANVCLKQKAPLLYSQSWLTMAKMCLADGKLAKRYLPLFAQELEKSDCAALRNNLVVAMTDFCVHYTAMIECYIPKITKRLRDPCEVVRRQTFILLSRLLQRDYVKWRGVLFLRFLLSLVDESEKIRRLADFLFGSILKVKAPLLAYNSFVEAIYVLNDCHAHTGHSNPDSKQSRTKDQVFSIRGNDERARSKRMQIYVTLLKQMAPEHLLATFAKLCAEILAAASDGMLNIEDVTGQSVLQDAFQILACKEIRLSVSRGASSETADIEEEGGDAATAKGRAITHAVRKGLIQNTIPIFIELKRLLESKNSPLTGSLMDCLRVLLKDYKNEIEEMLVADKQLQKELVYDMQKHEAAKARSMANQGVACGTSHRNGEPEASAASEENVRDSGLESRVVSAAADVVAAKAARSVLREVNGGAATPPLSAMSVPKLRSSRGVSQSGRPSADVLESLRRRPTFMSDDES