wanglab/gogpt-training-data huggingface dataset:
Protein: Dynactin subunit 2 (Q54N50)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Dynactin 150 kDa subunit
- Dynactin subunit 4
- Dynactin subunit 6
- Dynactin subunit 5
- Dynein heavy chain, cytoplasmic
- F-actin-capping protein subunit beta
- Cytoplasmic dynein 1 intermediate chain
- F-actin-capping protein subunit alpha
- Cytoplasmic dynein 1 light intermediate chain 1
- Dynamin-like protein B
Sequence:
MSEGNQPKRVLGLPDVDPSQQDTFETPDPPESISNLADESSELVNESIDRSSLKPAKSHLKFANRKFNNDNEDFSDSIYKKSVPRTGGLLKNQTVFDILPSDESKVETPLQKFQRLQYEVMSFREEMQVIADNGGEVEKDIKGVDLTHQLADLQNQLSHLLENEKLQPILDENKQVIHYSQIQNNSSKKLISEIESFTQQSLSSSTTEQNTQQPSNNNTTTNITSSSSITPNHVTYELFYTGEQSKSQQLQRIQDLEKRLAKLETATGNKTTDSVPITQSILEIKEKLSLLDTTKIDVLQQKMKTVSKEMESLKIQDETSTKALTTNEKKINDIFETMNKWDIVGQQVPAIINRLYTLRSLHEEGISFSNHVSNLEKQQNDITSLLISNSSLMNKMDDSFKSNLLTIKSNIQQLESRIETLQNRQQQQQQ
Protein: DNA polymerase IV (Pol IV) (EC 2.7.7.7) (Q74CQ6)
Organism: Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|HAMAP-Rule:MF_01113}.
Interaction partners:
- LexA repressor 2
- Beta sliding clamp
- Protein RecA
- DNA-directed DNA polymerase
- LexA repressor 1
- DNA repair protein RecN
- DNA helicase RecQ
- UvrABC system protein A
- DNA polymerase I
- Pyruvate:ferredoxin oxidoreductase
Sequence:
MSNHRTILHLDMNAFFASVEQQADPSLQGKPVAVIGSGARTIITTASYEARAHGVGTGMTTHEAKRLCPELILVIGNNREYTRISKLIFEMLGQFTPLVEVFSIDEAFLDLTGSLRLFGRADVIAREIKARIRDRFGLTCSIGIAPNKLLAKLASDMQKPDGLTIIPPENVASLMKTTPIRSLCGIGPSTEQRLKYLGISTCNDLGHFSSKILTRHFGAMGARLKQMGQGIDDSPVIPTTTEEEVKSVSHSTTLDHDLTNKDDIHKYLLMLSEMVGRRARRYKTKGKTVTLTIRYADFTTFSRQETLPSPLNRSGDIYRAVTALLDTLQLTQPIRLLGVAISNLVHASEQLPLFPEERRLTTLSQAMDQVNDRFGETTITFGTLLGQDNCSHVIAPAWRPAGIRDVKVK
Protein: TOM1-like protein 2 (Q9LNC6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds ubiquitin in vitro. Might contribute to the loading of the ESCRT machinery (Probable).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22639582}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Glutathione gamma-glutamylcysteinyltransferase 2
- Protein MODIFIER OF SNC1 1
- HAT transposon superfamily
- Protein PHOX1
- HAT transposon superfamily
- HAT transposon superfamily
- Terpenoid synthase 1
- Monooxygenase 2
Sequence:
MDKLKIAEWGEKLKTGGAQMSRMVSEKVKDMLQAPTLESKMVDEATLETLEEPNWGMNMRICAQINNDEFNGTEIVRAIKRKISGKSPVSQRLSLELLEACAMNCEKVFSEVASEKVLDEMVWLIKNGEADSENRKRAFQLIRAWGQSQDLTYLPVFHQTYMSLEGENGLHARGEENSMPGQSSLESLMQRPVPVPPPGSYPVPNQEQALGDDDGLDYNFGNLSIKDKKEQIEITRNSLELLSSMLNTEGKPNHTEDDLTVSLMEKCKQSQPLIQMIIESTTDDEGVLFEALHLNDELQQVLSSYKKPDETEKKASIVEQESSGSKDTGPKPTEQEEQEPVKKTGADDDKKHSEASGSSNKTVKEEKQAVKIELGLSSDEDEK
Protein: Ras-related protein Rab-1A (EC 3.6.5.2) (Q6NYB7)
Organism: Rattus norvegicus (Rat)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Required to modulate the compacted morphology of the Golgi. Regulates the level of CASR present at the cell membrane (By similarity). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (By similarity). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity).
Subcellular location: Golgi apparatus {ECO:0000250|UniProtKB:P62820}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P62820}. Early endosome {ECO:0000269|PubMed:21303926}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62820}. Membrane {ECO:0000250|UniProtKB:P62820}. Melanosome {ECO:0000250|UniProtKB:P62821}. Note=Alternates between membrane-associated and cytosolic forms. {ECO:0000250|UniProtKB:P62820}.
Interaction partners:
Sequence:
MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC
Protein: Probable glutamate carboxypeptidase LAMP1 (EC 3.4.17.21) (Protein LIKE AMP1) (Q7Y228)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in association with AMP1 to suppress ectopic stem cell niche formation in the shoot apical meristem (SAM) independently of cytokinin signaling pathway.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:25673776}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 78A7
- Uridine 5'-monophosphate synthase
Sequence:
MSKSKSLAFVIAALSYSFFSLFSSPPKSHYHELFISTSFSDNASVALNLHTLTRRPHVAGTVANAEAAEYVRSVFTSSALKSHVVAYQVSLTYPVHRSLVLTPTDSAKPITFLLEQEKLGDNPYANEVMPTFHGYAKSGNVSGPVVYANYGRVEDFVRLKKDMGVNVSGAVVIARYGQIYRGDIVKNAYEAGAVGVVIYTDKRDYGGDEWFPASKWMPPSGVQVGTVYNGLGDPTTPGWASVDGCERLSDEAVELSGDVPLIPSLPVSAADAEVILKTVVGDVSDGDVYPVGPGPGVLNLSYIGETVIAKIENVIGVIEGEEEPDRYVILGNHRDAWTFGAVDPNSGTAVLMEIAQRLDKLQKRGWKPRRTIILCNWDAEEYGLIGSTEWVEENREMLSSRAVAYLNVDCAVSGPGFHASATPQLDELIKVAAQEVRDPDNATQTIYESWIGSSDSVVIRRLGGGGSDYASFVQHVGVPGVDMSFGRGYPVYHSMYDDFTWMEKFGDPMFQRHVAMASVLGLVALRLADEEIIPFNYTSYALELKKSAEDLENEKLGHNIDVSTLIKSIEDLSTAAKHISLEKEAIKGALKVRELNDRLMMAERALTDRDGLSERPWYKHLIYGPSKYDDYGSKSFPGVDDAIDNAKKLNTKASWENVQHQIWRVSRAIRHASLVLKGELI
Protein: Uncharacterized protein (Q586Y7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- 50S ribosomal protein L14, putative
- Uncharacterized protein
- Uncharacterized protein
- Peptidyl-prolyl cis-trans isomerase
- 50S ribosomal protein L13, putative
- Large ribosomal subunit protein bL21m
- Tetratricopeptide repeat
Sequence:
MPICPGLCGELAAVPFRVFLGTLPTLAVEERCLRQLQPVFAWYSSRKRVKEQANEFIEIDLASCDAELLLRYSHIYYVRRQLFDELIERQMTLLDSGKAPRMAEPSLLQCLAGCNTTIADRLQLEIRQLGAAKRAASVPGRRELDPVARLEVYDYACMMRLVEEDAGAVEDAEMKARAYLPREVIESKLGHFTQLLLGSDARAALDKKDVKLLNRMIPPDYTRVGCVEKLRPFDVTAYFRFYGERINNVKVENYFKRALWGHVYRRFATTPSFLSGVSTYWARHSGLDASFTTTTMPQEVAVAVCDQQIQFPAIKFRAQYVYTSPETARQLWRTDAAVPLMRLFPLMGSRAAEDLAAGVLTDAFWMHLGLSEEENLLQDSLLLKVRRFVDEVGDMYETNIDSVLKRVDDNFKQVVPQLKAEDLQVDAPLQDGEGEDTVRETVAA
Protein: T-cell leukemia/lymphoma protein 1B (Oncogene TCL-1B) (Oncogene TCL1B) (SYN-1) (Syncytiotrophoblast-specific protein) (TCL1/MTCP1-like protein 1) (O95988)
Organism: Homo sapiens (Human)
Function: Enhances the phosphorylation and activation of AKT1 and AKT2.
Interaction partners:
- RAC-alpha serine/threonine-protein kinase
- RAC-beta serine/threonine-protein kinase
- T-cell leukemia/lymphoma protein 1A
- RAC-gamma serine/threonine-protein kinase
- Protein p13 MTCP-1
- Mediator of RNA polymerase II transcription subunit 1
Sequence:
MASEASVRLGVPPGRLWIQRPGIYEDEEGRTWVTVVVRFNPSRREWARASQGSRYEPSITVHLWQMAVHTRELLSSGQMPFSQLPAVWQLYPGRKYRAADSSFWEIADHGQIDSMEQLVLTYQPERKD
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Q76NQ0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU361143}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU361143}.
Interaction partners:
- GH11935p
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- DSec61alpha
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- dolichyl-diphosphooligosaccharide--protein glycotransferase
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
- Malectin domain-containing protein
- Mannosyl-oligosaccharide glucosidase
Sequence:
MYVSKFEASMATNFVIYLALGALLCLATANGEIVNTNVERTLDLTSQLVKTTTKISAEDSAGKPIVEYVFFTSEPSLAYIDVKDASDKSVPFKRNEPVKGEQSFTFTFPRAAAKQTFIVETVASKGIRPHPEEIRQNDKQFVKYTGNLHLYSKYRTNSQKTNVKLSSSNILSHTQVKPFSVSSNKITLGPYENVEAFSQEPLVIHYENSAPFVTVNTLERTLEISHWGNIAVQESIQMTHTGAKLKGSFSRYDFQKEGRSGLAALKSYKTYLPASASGVYYRDTNGNISTSNMNAVRDFIELELRPRFPLFGGWKTQYTLGYNVPSYEYMFNDGNKYQLKMHLIDHIYDNMAIDEATIKIILPEGSSDIRLSTPYSISRLPNELVHTYLDTIGRPVVSFSKSNLVESHISDFTLHYSFSKTSMLQEPLLVSGFIYIIFLFTIVFLRLDFSITSHAHKE
Protein: Tumor necrosis factor receptor superfamily member 10C (Antagonist decoy receptor for TRAIL/Apo-2L) (Decoy TRAIL receptor without death domain) (Decoy receptor 1) (DcR1) (Lymphocyte inhibitor of TRAIL) (TNF-related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (TRAIL receptor without an intracellular domain) (CD antigen CD263) (O14798)
Organism: Homo sapiens (Human)
Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 10
- Tumor necrosis factor receptor superfamily member 10D
- Tumor necrosis factor receptor superfamily member 10B
- Tumor necrosis factor receptor superfamily member 10A
- CASP8 and FADD-like apoptosis regulator
Sequence:
MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMITSPGTPASSHYLSCTIVGIIVLIVLLIVFV
Protein: Emp24p (Q59V63)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037847}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037847}. Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}.
Interaction partners:
- Endoplasmic reticulum vesicle protein 25
- Erp5p
- GOLD domain-containing protein
- Mitochondrial 37S ribosomal protein MRPS35
- Protein transport protein SEC23
- Erv29p
- Small COPII coat GTPase SAR1
- Protein transport protein SEC13
- Cornichon family protein
- Protein transport protein SEC24
Sequence:
MKSLFVSLFLFFISSISAHNVLIAPYGKQCFYESLNKNDELAISFQVGSRNPYNSEQYTIDFYINSPQGQTVLKKTGLDHGDETITATSSGKYSYCFSNERTGVVDLDVSFNIHGVVYVDVNDPKSGTLDYAIQKLSQLTDDVRAEQGYLVIRERTHRNTAESTNSRVKWWSVFQIFVVAANSIFQIYYLRRFFEVQSVV
Protein: histone deacetylase (EC 3.5.1.98) (D6XGM6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone deacetylase 2
- Trans sialidase, putative
- Histone deacetylase
Sequence:
MSVRERNKNPWAHGRQLDLDGDVTVRCQADPRLCTTAAIRRGKLVEPVDQVALRVGVEASGVESLVDAQGITFFGSLKNGMEVFVSGPAMLDAAKTDNDNSDLFLPDVSVAWAYDPRVLEHVPPVDRVPETPYRLQRAVEALRSAPRAAHFLPMELQSSGERSPPREGAPVGTGATAGETPSAAPSGTPLWIPPRLATLDEVTLCHNIHRYRCFIEEGTALLPPLKTDVYCNGKTSSIATRLSVGAVVDAARRALSGSPAFAFCLVRPPGHHASADTPSGFCLVNNVAIAAMQLLQDWHVKYDCGVGGSRSVPSEERDIPERPRIAIVDIDVHHGEGTQSFVEVEPQLLYLSLHRYDRGSFYPCDPAGATSYVGQHRNICNVAVDTAATDPARCEEVISDMLFARVVDDVFLPRLEQFHPNIILLSLGFDAAHGDPLGRMAVEGGFAYVVRALKRFCLQSQGTIGLVAVLEGGYSPEGVSRGVVSVAHALCYPFDDVAVVNYARLRTPKTWMELRSRLSRRMEVRTDETGGATSLSSGLSSQGLGDATSTERAIADDDVLMERHVAWCDKLVKRVLAIHAESNIIK
Protein: Nascent polypeptide-associated complex subunit alpha (Alpha-NAC) (Alpha-NAC/1.9.2) (Q60817)
Organism: Mus musculus (Mouse)
Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). Isoform 1 and isoform 2 appear to bind DNA and play roles in transcription. Isoform 1 may function as a specific coactivator for JUN, acting to stabilize the interaction of JUN homodimers with promoter elements.
Subcellular location: Cytoplasm. Nucleus. Note=The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus. {ECO:0000250}.
Interaction partners:
Sequence:
MPGEATETVPATEQELPQPQAETGSGTESDSDESVPELEEQDSTQTATQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM
Protein: GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2) (Q8VHI3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (By similarity). The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm.
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Y2G5}. Golgi apparatus {ECO:0000250|UniProtKB:Q9Y2G5}. Note=Mainly located in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9Y2G5}.
Interaction partners:
- GDP-fucose protein O-fucosyltransferase 1
- Beta-1,3-glucosyltransferase
- ADAMTS-like protein 2
- 18S rRNA aminocarboxypropyltransferase
- Alpha-
- ADAMTS-like protein 1
- GDP-fucose protein O-fucosyltransferase 4
- Endoribonuclease YbeY
Sequence:
MAALSVVCLLLAAASWRPVSASGEEFWPGQSAADILSGAASRRRYLLYDVNPPEGFNLRRDVYIRVASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVIEYEQFIAESGGPFIDQVYVLQGYAEGWKEGTWEEKVDARPCIDPLLYSQDKHEYYRGWFWGYEETRGLNVSCLSVQGSASIVAPVLLKNTSARSVMLDRAENLLHDHYGGREYWDTRRSMVFAKHLRAVGDEFRSQHLNSTDAADKMAPEEDWTKMKVKLGSALGGPYLGVHLRRKDFIWGHREDVPSLEGAVKKIRSLMKTHQLDKVFVATDAIRKEQEELRKLLPEMVRFEPTWEELELYKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACEQPTHWKIAY
Protein: Lanosterol 14-alpha demethylase (LDM) (EC 1.14.14.154) (CYPLI) (Cytochrome P450 51A1) (CYP51) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase P450) (Q64654)
Organism: Rattus norvegicus (Rat)
Function: A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:8797093}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:8797093}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Lanosterol synthase
- Squalene monooxygenase
- Transmembrane 7 superfamily member 2.
- Squalene synthase
- Methylsterol monooxygenase 1
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Delta
- Ergosterol biosynthesis 28 homolog
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
Sequence:
MVLLGLLQSGGSVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPYIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEEVYGRLTTPVFGKGVAYDVPNAVFLEQKKILKSGLNIAHFKQYVSIIEKEAKEYFKSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDKPLQDKCYLEQKTVCGEDLPPLTYEQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLINGYFPSVNYTTMIHTPENPVIRYKRRSK
Protein: ethanolamine kinase (EC 2.7.1.82) (Q386V0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Choline/ethanolamine kinase, putative
- Ethanolamine-phosphate cytidylyltransferase
- Uncharacterized protein
- Raptor N-terminal CASPase-like domain-containing protein
- Raptor N-terminal CASPase-like domain-containing protein
- Ethanolaminephosphotransferase, putative
- Ras-family member, GTP-binding protein, putative
- Small GTPase, putative
Sequence:
MEVAVGHVRHVPCTVPDDPASRMRAIREIVARHCALFMQKGGDVGRSQCASNLGNNITSGTSNGFDADRLQVVAFSGGITNEMYHVYCEGWEAHSVVMRIFGKETERVISRGDELFYQSLFIPTYVRGQNFLVYQYLYQYEPLPFVEMVKEYEKIARGIAFFHVRATLEARSDYSVTPVGGVVGAGGATVGPTNTCSRFDLEENYIVHSLTEWVEQALSETVQEKVDATKRATYASVAQQLKEEAQWLLPLMQRHSPELGESTCHNDLLSGNIMRQKSDGALKIIDFEYAKRNYFLFDIANHFNEYTGLECDYATYFPSEEHMKKFVTTYMCAMREELEKHAEEAKRRQLTDIIPGQQHFFMCDVGGVEGDKRIHRMVQLVKLLTLASHLSWSVWALLQEAVSKTDMDFLRYSQLRLSRYLETRKEFSASS
Protein: C6 finger transcription factor fumR (Fumagillin gene cluster regulator) (Q4WAY8)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of pseurotin and fumagillin.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
Interaction partners:
Sequence:
MDVNRKRMVRMASAQRSEMLVRLSGKAKRWTVGGGGEVETHTFHTFCAGQKSYKSVVRRQRPRIARRDSRPSHPIANRGMNMLVHDLGFSHRACDRCHGQKLRCRRENNSDTCVRCARAGVRCTPRPMRLRSRAQSTKNTQQQQSQSPANGGSTQQLHVNQEQGPNDTNDEHSDHFEYLPTSLLDMPTDLNMGMDPSSLQVDIHPALTAPYGPEGSVHTSQPSGPQAPSHLRTAEQAGQTRWSDAPNLDTSDELYDFSLPATMRSSFPATYHRHRASLARNMSPQPAHQQGRDDMMVDFDQAEGNPRGSDGKDSRADSGYGNELSPSDLLRSPYGDAPDSDSELQPRGNSQDQGEQSNSILDTRHQNMTSWIRRLSDTNVQLHQHMQSIPLVGTGKKTRGSGAGTSLSPMELPVDSTFKLSSQYTGLLTSICARLQACRSCNDSQALAQLALDQPSQLLVLSSYMCLLASYDRILQHIEAWLKVRLKMGVRGSAMTLDDDESSSCFPTQLPSLAVGSFEVPKTSSIQSLVLTCIMETNVMHMHSLISEIMRPVSHPATGSASKTAASGPPAAEKRPGNGAADAGDGLSTVAKVTLQAIEANEDSTLRLVHTVSRLALQRVML
Protein: Transcription factor atoh7 (Atonal bHLH transcription factor 7) (Helix-loop-helix protein zATH-5) (zATH5) (Protein atonal homolog 5) (Protein atonal homolog 7) (Protein lakritz) (Q8AW52)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity). Involved in the differentiation of retinal ganglion cells, photoreceptor population and optic nerve development. Required for retinal circadian rhythm photoentrainment (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8N100}. Perikaryon {ECO:0000250|UniProtKB:Q9Z2E5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2E5}.
Interaction partners:
- Visual system homeobox 2
- Visual system homeobox 1
- POU domain protein
- Transcription factor HES-5
- Paired box protein Pax-6
- Six3
- Insulin gene enhancer protein isl-1
- Forkhead box protein N4
- Growth-associated protein 43.
- Sine oculis homeobox homolog 3a.
Sequence:
MKPRRPSCADSGSDSDSRDPEKFESAMRRRMAANARERKRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMALNRILSDAGRHVDPQKDWLNLQFDGLQTEGYFMHYDSPVESDCMLSSFSYHYESL
Protein: AP2/ERF and B3 domain-containing transcription factor ARF14 (Protein AUXIN RESPONSE FACTOR 14) (RAV1-like ethylene-responsive transcription factor ARF14) (Q9LS06)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Alcohol dehydrogenase transcription factor Myb/SANT-like family protein
Sequence:
MDAMSSVDESSTTTDSIPARKSSSPASLLYRMGSGTSVVLDSENGVEVEVEAESRKLPSSRFKGVVPQPNGRWGAQIYEKHQRVWLGTFNEEDEAARAYDVAAHRFRGRDAVTNFKDTTFEEEVEFLNAHSKSEIVDMLRKHTYKEELDQRKRNRDGNGKETTAFALASMVVMTGFKTAELLFEKTVTPSDVGKLNRLVIPKHQAEKHFPLPLGNNNVSVKGMLLNFEDVNGKVWRFRYSYWNSSQSYVLTKGWSRFVKEKRLCAGDLISFKRSNDQDQKFFIGWKSKSGLDLETGRVMRLFGVDISLNAVVVVKETTEVLMSSLRCKKQRVL
Protein: Protein GOLVEN 10 (CLAVATA3/ESR (CLE)-related protein CLEL7) (CLE-Like protein 7) (Root meristem growth factor 5) (AtRGF5) [Cleaved into: GLV10p] (B3H5J1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Signaling peptide (root growth factor) that maintains the postembryonic root stem cell niche. Regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells.
Subcellular location: [GLV10p]: Secreted {ECO:0000305|PubMed:22307643}.; SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:22307643}. Note=The precursor is detected in the endoplasmic reticulum probably during its processing. {ECO:0000269|PubMed:22307643}.
Interaction partners:
- LRR receptor-like serine/threonine-protein kinase RGI3
- Protein GOLVEN 3
- Protein GOLVEN 1
- Protein GOLVEN 5
- Protein GOLVEN 7
- Protein GOLVEN 9
- Root meristem growth factor 10
- Protein GOLVEN 6
- CLAVATA3/ESR
- Protein GOLVEN 11
Sequence:
MSSIHVASMILLLFLFLHHSDSRHLDNVHITASRFSLVKDQNVVSSSTSKEPVKVSRFVPGPLKHHHRRPPLLFADYPKPSTRPPRHN
Protein: Cytochrome c oxidase subunit 5B, isoform A (Cytochrome c oxidase subunit 5B, isoform B) (RE06394p) (Q9VMB9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 4
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Levy, isoform A
- Cytochrome b-c1 complex subunit 9
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit
- Cyclope, isoform A
- Cytochrome b-c1 complex subunit 7
Sequence:
MASICGRMALRAAARQNVAYTPVRFCKMMNDPLEHATGIEKRELLLKAAGNDNPFDMKVFKRGAGTKENPNLIPSAFDARIVGCICEEDQTYVQWMWLQKGNQKRCECGHWFKLVEKAAV
Protein: trimethyllysine dioxygenase (EC 1.14.11.8) (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (TML hydroxylase) (TML-alpha-ketoglutarate dioxygenase) (A0A1D8PNJ2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Aldehyde dehydrogenase domain-containing protein
- low-specificity L-threonine aldolase
Sequence:
MSVALATPIKDFIELKWSDTAISKYHNIWLRDNCHCEKCHYSLTKQRLLNSATINPDIKPKSIDLKQDGLNIIWDQEDHESKYDFNWLRLHSYQPRLIPIDEKLKDGKKLLKREFWQVKEIEKNLPTVDYNKIMESTDNNNENAIKDWVLKIWKHGFCLIDNVPVTPEDTEKLCEKLNYIRPTHYGGFWDFTSDLAKADTAYTNFDISSHTDGTYWSDTPGLQLFHLLYHDGTGGTTSLVDAFKCAEILKQKYPESYEIFCRIPVPAHSAGEEKVCIQPDEYNPIFKLDDQGQLLQVRWNQSDRSTMDNWENPETDIPRFYQAIRNWVEIITSPENEMWYQMKPGQCLIFDNWRVFHSRSEFTGKRRLCGAYFERDDFVSRLKLLVLGRQAVLDAI