wanglab/gogpt-training-data huggingface dataset:
Protein: Cell division control protein (Q9VSM9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR001767}.
Interaction partners:
- Double parked, isoform A
- Origin recognition complex subunit 2
- DNA replication licensing factor Mcm3
- Origin recognition complex subunit 6
- DNA replication licensing factor Mcm5
- Origin recognition complex subunit 5
- DNA replication licensing factor MCM4
- DNA replication licensing factor Mcm2
- DNA replication licensing factor Mcm6
- DNA replication licensing factor Mcm7
Sequence:
MAAVRRSTRLSSISKATAASPLPPSTQTPRRSEVWKRRQPKKVLADSDEEEEVVTAIYDLTSPVSENNENRNVLNKMDKISRRRTSQVQVAQSELPKTPRSTKKTVQSAGSSRAKREEENREATARFLEGEQDSEVDPLHGSPPKQRKLQPLPQHLISPSRLLDRLSIDERQEEEVEATTHKTETAEQQPKHQAKDEAKPRPKQQEDPLAQKQQEKPPTKQPNKNQTKEKSNIQTNEETQQNNLPSPSRNKYQNARRVLNSAETQNLPGRESQLQELREFFSNHLESQTSGSLYVSGQPGTGKTACLSLLLRDPDFSKRLQRVYINCTSIASVGAVYKKLCTELQLKVSGRTERDHLEAIQRHLKTAKRMLLLVLDEIDQLCTSRQEVLYTIFEWPALPGSRILLVGIANSLDLTDRALMRLNARCELKPRLMHFPPYSKQQIVEIFKSRLAEAEVLDVFPPVTLQLLAAKVSAISGDVRRALDIGRRVVEIAEQQKRDGEKEFNMKALQLEGKDAVEAKEKQDTLKPVQVTQVAAVLNKVYGASQNLEEDIEASFPLQQKLMLCTLVLMLRNERNKDISMGRLHEVYRRVCAKRNILALDQAEFTGTVDLVETRGILRIMRKKEPRLHKVLLQWDEEEVHAALSDKQLIASILSDTACLSK
Protein: Polycomb protein SCMH1 (Sex comb on midleg homolog 1) (Q8K214)
Organism: Mus musculus (Mouse)
Function: Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Polycomb complex protein BMI-1
- Polycomb group RING finger protein 2
- E3 ubiquitin-protein ligase RING2
- Polyhomeotic-like protein 1
- Chromobox protein homolog 2
- E3 ubiquitin-protein ligase RING1
- Chromobox protein homolog 8
- Polyhomeotic-like protein 3
- E3 SUMO-protein ligase CBX4
- Polyhomeotic-like protein 2
Sequence:
MLVCYSVLACESLWDLPCSIMGSPLGHFTWDKYLKETCSVPAPVHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIKIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGAEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPSPSSDVSTEKPSIHSTKTVLEHQPGQRGRKPGKKRGRTPKILIPHPTSTPSKSAEPLKFPKKRGPKPGSKRKPRTLLSPPPTSPTTSTPEPDTSTVPQDAATVPSSAMQAPTVCIYLNKSGSTGPHLDKKKIQQLPDHFGPARASVVLQQAVQACIDCAYHQKTVFSFLKQGHGGEVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLTATEYNHNHDRYLPGETFVLGNSLARSLETHSDLMDSALKPANLVSTSQNLRTPGYRPLLPSCGLPLSTVSAVRRLCSKGVLKGKKERRDVESFWKLNHSPGSDRHLESRDPPRLSGRDPSSWTVEDVMQFVREADPQLGSHADLFRKHEIDGKALLLLRSDMMMKYMGLKLGPALKLSFHIDRLKQVFWKRETILWSREGLSREVWPISEDTALGHFFSGMDKVFGSLSKR
Protein: Protection of telomeres protein 1 (Q3TNS5)
Organism: Mus musculus (Mouse)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSAPVAPSTYTPLNLLKEGTVVNVCGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCMLFSRDYDTLPSVYKVGDIVCFQGLKIQAYKNELQAISKFGFASLTFDGTLGAPIILRTLSKRFNFTAQDYSMVEALRTWASTHISASSNLVQLSDAQPMQYYDLTCQLLGKAQVDGVSFLLKVWDGTRTKIPSWRVCIQDVAFEGDLSHILQLQNLVVDIVVYDNHVQVAKSLKIGSFLRIYSLHTKLQPINSESTTSLVRLEFHLHGGTSYGRGIRVLPESNYDVDQLKKALESVDLEAIQTSDDTYQSDNVENCLTSSSSESDLVSLYEVERCQPLCATTLTGYHHLEKTSLCDILKQRAPRQYRIRAKLRSYKPRRLPQSVKLFCPKCHLLQEIPSEENVDKILQDATATAPDCKLQDTPLYDSEVWTTEGQGGRQVAVHFVKNDGVLPHSSECLVLIEGGRLCEISRLSSMFHSVIPVRSGPEDLELVDLAAPFLIRGKVCHYGCKQCSNLKTIQNLSIIPNKRLWIPSSVAEVLGIVPLQYVFVMTFMFDDGTGVLDVYLKDSEKFFQIPASEVLTDDDLQRNLEQIMNVICPPGIKIGRQHFKGASFSSLKIHLVCI
Protein: Probable methylmalonyl-CoA mutase small subunit (MCM) (EC 5.4.99.2) (P9WJK7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.
Interaction partners:
- Probable methylmalonyl-CoA mutase large subunit
- Conserved protein
- Conserved protein
- Probable GTPase Rv1496
- Succinate--CoA ligase subunit beta
- Succinate--CoA ligase subunit alpha
- 2-oxoglutarate oxidoreductase subunit KorA
- Putative citrate synthase 2
- Citrate synthase 1
- 2-oxoglutarate oxidoreductase subunit KorB
Sequence:
MSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYTAFDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPACDVMLALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATAATELAATVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGGGAAVVHAETSLPMMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRLARRAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYAAGFEALRDRSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICGTDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA
Protein: von Hippel-Lindau tumor suppressor homolog (Q19213)
Organism: Caenorhabditis elegans
Function: Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size. Mediates resistance to enteropathogenic E.coli. Mediates susceptibility to B.thuringiensis pore-forming toxins. Not involved in P.aeruginosa susceptibility.
Interaction partners:
- Hypoxia-inducible factor 1
- Cullin-2
- RNA polymerase II transcription factor SIII p18 subunit
- RING-box protein 1
- Elongin-C
- Hypoxia-inducible factor prolyl hydroxylase
- Zyg eleven-related protein 1
- Elongin-C
- Regulator of hypoxia-inducible factor 1
- Leucine-Rich Repeat protein
Sequence:
MSDGSMDDDGRLFPDLGSSTHDNREIRVRFLNRCAYPVDVFWLNPSKQPTKYGTLAQKKYLDIKTFKDHPWVARRSFDGCKVLVNEKEVFWPEPAPRMNLIVRNHCVITMKVQSLREIAGRSFLRHNPTEVPNKIKGLPRELQFEVKHFLDRKQEYSEIVCRSIPPPGPQRPQQ
Protein: Uncharacterized protein (A0A178VUV0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTICMCCDSHLVAKSILNPWNSPRITKLGFVPVVRRFPATTTVKASAVDSPESSSNFAKRMDQAWIISQQPSPVGCSSCNSKGHVECKWCAGTGFFILGDNMLCQVPSRNTSCVICSGQGSASCSDCKGTGFRAKWLEKPPVPT
Protein: Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2) (Q5EP34)
Organism: Influenza A virus (strain A/Vietnam/1203/2004 H5N1)
Subcellular location: Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04063}. Host nucleus {ECO:0000256|HAMAP-Rule:MF_04063}. Note=PB1 and PA are transported in the host nucleus as a complex. {ECO:0000256|HAMAP-Rule:MF_04063}.
Interaction partners:
Sequence:
MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERSESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEEKFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLLAWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFEDCKDVSDLRQYDSDEPESRSLASWIQSEFNKACELTDSIWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAVGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIAQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLAHALK
Protein: Putative actin-23 (EC 3.6.4.-) (Q55EU6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Arginyl-tRNA--protein transferase 1
- Actin-related protein 2/3 complex subunit 1
Sequence:
MCKAGFAGDDAPCTVFPSIVGRPRHTGVMVGMCQKGSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFEAEMQTATSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPPERKYSVWIGSILASLSTFQQMWISKEEYDESGPSIVHRKCF
Protein: polynucleotide adenylyltransferase (EC 2.7.7.19) (Q9NDU2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MWNSEPTHRQHHQHNGNSTSGGPPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEISVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVTECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDEILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGV
Protein: AP-1 complex subunit mu-2 (Adaptor protein complex AP-1 subunit mu-2) (Adaptor protein-1 mu-adaptin 2) (Adaptor-related protein complex 1 subunit mu-2) (At-muB2-Ad) (Clathrin assembly protein complex 1 mu-2 medium chain) (Mu1-adaptin 2) (Protein HAPLESS 13) (O22715)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Required for KNOLLE localization at the cell plate to mediate cytokinesis. Functions redundantly with AP1M1 in multiple post-Golgi trafficking pathways leading from the TGN to the vacuole, the plasma membrane, and the cell-division plane.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:23543752, ECO:0000269|PubMed:23733933, ECO:0000269|PubMed:23766365}; Peripheral membrane protein {ECO:0000305|PubMed:11598180}; Cytoplasmic side {ECO:0000305|PubMed:11598180}. Early endosome membrane {ECO:0000269|PubMed:23766365}; Peripheral membrane protein {ECO:0000305|PubMed:11598180}; Cytoplasmic side {ECO:0000305|PubMed:11598180}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000305|PubMed:23733933}; Peripheral membrane protein {ECO:0000305|PubMed:11598180}; Cytoplasmic side {ECO:0000305|PubMed:11598180}.
Interaction partners:
- AP-1 complex subunit sigma-1
- AP-1 complex subunit sigma-2
- AP-4 complex subunit epsilon
- AP-1 complex subunit gamma-1
- AP-1 complex subunit gamma-2
- AP-4 complex subunit sigma
- Beta-adaptin-like protein C
- Beta-adaptin-like protein B
- Clathrin heavy chain 2
- Beta-adaptin-like protein A
Sequence:
MAGAASALFLLDIKGRVLVWRDYRGDVSAAQAERFFTKLIEKEGDSQSNDPVAYDNGVTYMFVQHSNVYLMIASRQNCNAASLLFFLHRVVDVFKHYFEELEEESLRDNFVVVYELLDEMMDFGYPQYTEARILSEFIKTDAYRMEVTQRPPMAVTNAVSWRSEGIQYKKNEVFLDVIENVNILVNSNGQIVRSDVVGALKMRTYLTGMPECKLGLNDRVLLEAQGRATKGKAIDLEDIKFHQCVRLARFENDRTISFIPPDGAFDLMTYRLSTQVKPLIWVEAQIESHSRSRVEMLIKARSQFKERSTATNVEIELPVPTDASNPTVRTSLGSASYAPEKDALVWKIKSFPGNKEYMLRAEFHLPSITAEEATPERKAPIRVKFEIPYFTVSGIQVRYLKIIEKSGYQALPWVRYITMAGEYELRLV
Protein: Protein S100-G (9 kDa CaBP) (Calbindin-D9k) (Cholecalcin) (S100 calcium-binding protein G) (Vitamin D-dependent calcium-binding protein, intestinal) (CABP) (P02634)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Calbindin
- Transient receptor potential cation channel subfamily V member 6
- Parvalbumin alpha
- Plasma membrane calcium-transporting ATPase 1
- 45 kDa calcium-binding protein
- Transient receptor potential cation channel subfamily V member 5
- Calretinin
Sequence:
MSAKKSPEEMKSIFQKYAAKEGDPNQLSKEELKLLIQSEFPSLLKASSTLDNLFKELDKNGDGEVSYEEFEVFFKKLSQ
Protein: Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) (Q9WU70)
Organism: Rattus norvegicus (Rat)
Function: Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane (By similarity). Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9620695}. Cell membrane {ECO:0000269|PubMed:9620695}; Peripheral membrane protein {ECO:0000269|PubMed:9620695}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9620695}; Peripheral membrane protein {ECO:0000269|PubMed:9620695}. Synapse {ECO:0000269|PubMed:9620695}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:9620695}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles.
Interaction partners:
- Multifunctional fusion protein
- Syntaxin-1A
- Syntaxin-11
- Synaptosomal-associated protein 23
- Syntaxin-4
- Syntaxin-1B
- Syntaxin-3
- Syntaxin-2
- Vesicle-associated membrane protein 3
- Beta-soluble NSF attachment protein
Sequence:
MRKFNIRKVLDGLTAGSSSASQQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAVLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPTKPVQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSIKFWDASAITLQVLYKLKTSKVFEKSRNKDDRQNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVVTEVIPMLEVRLLYEINDVETPEGEQPPPLSTPVGSSTSQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLALNSSYGLVVFGNSNGIAMVDYLQKAVLLNLSTIELYGSNDPYRREPRSPRKSRQPSGAGLCDITEGTVVPEDRCKSPTSGSSSPHNSDDEQKVNNFIEKVKTQSRKFSKMVASDLAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCETFTRKADSSPSPCLWVGTTVGTAFVITLNLPLGPEQRLLQPVIVSPSGTILRLKGAILRMAFLDAAGCLMPPAYEPWTEHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSVCLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANSGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLSDLEERTAAMMSSADSFSKHAHEMMLKYKDKKWYQF
Protein: Prolactin like (Prolactin-like protein) (C6ZDB7)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MALGRPAERAGPGAALALLWLLVRAAAPPAVCPPGDAGCRLLSVADLFDRVIRHSGRIHSLSTELEKYLTPRDNELGRPARKCHTATMLTPNGKEYAQKITREELTYLILKLLQAWKEPLSRFNQHIENLQELPGESLSKAKQISNMVHELETGVEKVTEKMQSMGIISNSLHGMASSEAAGLSISNEANVMSDSDFIHCFRRDSNKVQSYLKILKCRIMPENSC
Protein: Cycloartenol synthase LCA (EC 5.4.99.8) (A0A125SXN3)
Organism: Lycopodium clavatum (Stag's-horn clubmoss)
Function: Oxidosqualene cyclase involved in the biosynthesis of cycloartenol.
Interaction partners:
Sequence:
MWSLKIAEGGGPWMSSLNDHVGRQIWQYDDNGGTPQERSAIDALQAQFTRNRHDVRHSSDSIMRFQFSKDNPLPPLPLQVKVKGHEQLTRDIVEKTLRRALRFYSTIQANDGHWPGDYGGPMFLMPGLVITLYITGALRVILSEQHQLEMCRYLYNHQNNDGGWGLHIEGHSTMFGTILTYVTLRLLNQGSGAHAAMEKARAWILDHGGATAAPSWGKFWLAALGIFDWSGVDPLPPEMWLLPYILPVYPGRMWCHCRMVYLPMSYIYGRRYSSPLTKLTSDIRNEIYVVPYEEVNWDSARNDCAREDLYYPHPFLQDLLWATLHKCVEPILMHWPGSLLRQRALAMVIEHIHYKDENTRYVCIGPVNKVINMLCCWVENPNSEAFKKHLPRVLDYLWLAEDGMKMQGYNGTQLWDTAFAVQALVSTQLLDECGSMLKKAHHYIERSQVQEDCAGDLRRWFRHISKGAWPFSTRDHGWPISDCSSEGLKASLELSSLSGDLVGDPIPAQRLYDCVNVILSYQNPNGGIATYESTRSYAWLELLNPAETFGDIVIDYPCVECTSACVQALAAFKRKYPEHRSKEIATTIRQGSMYIKNVQRSDGSWYGSWGVCFTYGTWFGIMGLLASGETYSTSASLRNACSFLLSKQLPSGGWGESYLSSQDKTYTHLEGDEAHLVNTSWAMLALIASGQVERDPTPLHKAXVLLVNAQFENGDYPQQEIIGVFNRNCMISYSAYRNIFPIWALGAYQCKVLGH
Protein: Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) (P10070)
Organism: Homo sapiens (Human)
Function: Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development.
Subcellular location: Nucleus {ECO:0000269|PubMed:26565916}. Cytoplasm {ECO:0000250|UniProtKB:Q0VGT2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q0VGT2}. Note=STK36 promotes translocation to the nucleus. In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus. {ECO:0000250|UniProtKB:Q0VGT2}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:9557682}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:9557682}.
Interaction partners:
- Suppressor of fused homolog
- Kinesin-like protein KIF7
- THO complex subunit 2
- Speckle-type POZ protein
- Ubiquitin carboxyl-terminal hydrolase CYLD
- THO complex subunit 3
- F-box/WD repeat-containing protein 1A
- Protein smoothened
- Sonic hedgehog protein
- Protein patched homolog 1
Sequence:
METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGVPQHLLPPFHAPLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQMTLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSSSSNCLSDTNQNKQSSESAVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLRKHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPAGLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASPLGAGRPHNASSADSYDPISTDASRRSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGGPPPTPLPGLERMSLRTRLALLDAPERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHEAPGGGARRASDPVRRPDALSLPRVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTDGGLARGAYSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDEGTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNKNNMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFGQYPGYSPQGLQASPGGLDSTQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTISGALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSPTGRHRGVRAVQQQLAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGAPDHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT
Protein: Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) (P16177)
Organism: Rattus norvegicus (Rat)
Function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Tachykinin-3
- Protachykinin-1
- Metastasis-suppressor KiSS-1
- Progonadoliberin-1
- Tachykinin-4
- NMDA receptor synaptonuclear signaling and neuronal migration factor
Sequence:
MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS
Protein: Signal transducer and activator of transcription 3 (C0PUF7)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
SLLTSLLKSAFVVETQPSMPQGKGPLVLRTNVQFSVKTRFLVKFPELNHAMKVNVSMDREAPLVKGYRRFNVLGTNSKALNMAESMSGGMVADFRHLTLKEQKSGGGGKGIHDLSLSVTEELHIINFNTEFLLHDMSVSLETSSLPVVIISNSSQQQSAWASILWFNMLCLEPKNLLFFANCPAATWPQLGEMLSWQFLSSTTRGLEANQLDMIAHKLFGKQQSYDACKISWTKFSKENVPNTNFTFCVWFDGILFMVKTHLENLWKDGSIMGFVSKGKEKTLLKKKRRGTFLLRFSESIRDGGITFSWVDYSPTGEPDVRSVQPFTKVDLCQIPFHEIIRNFQILEEENVPENPLLFLYPDTPKVEAFGKYYTEKSGADSQFFKYIRTKLVFVSKENTLEAKSLMYSDTVEGEGSGPMNPRYGLGGEAVEPSTFLPLPPSPDPMFPDAMVNPDEDLNPTFQEFLDDQSIYDCGDFLSDDTTFLEGALPGLPFTALLQPCE
Protein: Serine-repeat antigen protein 6 (EC 3.4.22.-) (Cysteine protease SERA6) (Q9TY96)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Cysteine protease which plays an essential role in merozoite egress from host erythrocytes. May cleave host SPTB/beta spectrin and ANK1/ankyrin-1 which disrupts host erythrocyte actin cytoskeleton and leads to host erythrocyte cell membrane rupture.
Subcellular location: Parasitophorous vacuole lumen {ECO:0000269|PubMed:22984267}. Parasitophorous vacuole membrane {ECO:0000269|PubMed:22984267}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
Sequence:
MICPIFFLYIINVLFTQYFIKCEGNKVTVISHNNGHNDNLDVNKNGVISQENVFDTSESLNLPSNKKVGSDDLNTTTISFTVPDNLENEVKVVSSSESGKGATVSHTKVTSEGLSDTQPNVTQSVSSSTHTPGSLDSTMSTEQHSSVSQSSLPTESSSETLNKATVPEIPIQINSGLLKNYNGVKVTGSCGSYFRVYLVPHILIYALTKYSVIQLESLFNDNARIDVEHKGELQNKCSEGYHFKLVVYITHNVLNLKWKTYKPNEESKSEDSDVRKYRIPKLERPFTSIQVYTANSKAGVIETKNYNIRTDIPDTCDAIATDCFLNGNVNIEKCFQCTLLVQKKDKSHECFKYVSSEMKKKMNEIKVKAQDDFNPNEYKLIESIDNILSKIYKKANKPFEISKDLINLEDLDYQFKNELLEYCKLLKKVDTSGTLEEYELGNAEDIYNNLTRLLKSHSDENIVTLQGKLRNTAICIKNVDEWILNKRGLTLPSESPSESSSKSDSYLNTFNDKDKNEDKDDMSKNSKEEFKNDDKENSDDQNNNDSNKKDDENNINNGDTNYVYDFDDDDYDNNSYEKDMYESPIKENKNGVIDLEKYGNQIKLKSPYFKNSKYCNYEYCNRWRDKTSCISQIEVEEQGNCGLCWIFASKLHFETIRCMRGYGHFRSSALYVANCSKRKPIDRCEEGSNPLEFLRILDEKKFLPLESNYPYSYTSAGNSCPKLPNSWTNLWGDTKLLFNKKVHRYIGNKGFISHETSYFKNNMDLFIDMVKREVQNKGSVIIYIKTQDVIGYDFNGKGVHSMCGDRTPDHAANIIGYGNYINKKGEKRSYWLIRNSWSYYWGDEGNFRVDMLGPKNCLYNFIHTVVFFKLDLGTIHVPKKKSWKKNVYFLRHNPDFMYSLYYNNYEPETSQDFESENDYDNAFVHGQSNESDETNKEGKNVHNSVEKKIQILHILKHIKDSQIKRGLVKYDNINETKDEHTCSRVNSQDAEKYEECKKFCLTKWNECKDHYSPGYCLTDLYKGEDCNFCYV
Protein: Anion exchange protein (Q9VT48)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU362035}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362035}.
Interaction partners:
- Sodium/hydrogen exchanger
Sequence:
MSFSSASGRENNVRKLSFLGFNTKKKSGNEDPDEVLLDSEMDKVFAGNSARKDKFDVNTFQDNSQLPIGSRKKNSIRTNDLNIEEDSEYESQTEPLNNAQNYDDIPEDFPLVSERAGHGDHSDNSVDEKHVQFGGKKKIPPSLSYDEQPTDQSHERKRRRSRHQYYRQRKFSHQDSVEPKNKLEENGDAGARRISVQPEDTALEEADLNELRSHRSDDPRALRRHKIHHSSIKLRELPQITISPFTNKKPEVDHSPHEIFVQLDELTGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVAHEHATNESLLNATASVTTNITQMVMNISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIGFDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDGSEMKKNDDDEPDFYEQTNIPA
Protein: E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (RING-type E3 ubiquitin transferase CHIP) (G5ECY6)
Organism: Caenorhabditis elegans
Interaction partners:
- Ubiquitin-conjugating enzyme E2 13
- Heat shock protein 90
- Ubiquitin conjugation factor E4 ufd-2
- Smad protein daf-8
- Ubiquitin-conjugating enzyme E2 2
- UBIQUITIN_CONJUGAT_2 domain-containing protein.
- Heat shock protein 110
- RING-type domain-containing protein
- BAG domain-containing protein
- BAG family molecular chaperone regulator 1
Sequence:
MSSGAEQHNTNGKKCYMNKRYDDAVDHYSKAIKVNPLPKYYQNRAMCYFQLNNLKMTEEDCKRALELSPNEVKPLYFLGNVFLQSKKYSEAISCLSKALYHNAVITNAPDIENALKRARHQKYEEEESKRIVQDVEFHTYLESLIEKDRQENSENPEELQRADMAKKRLTELTLATQEKRQNREVPEMLCGKITLELMKEPVIVPSGITYDREEIVQHLRRIGHFDPVTRKPLTENEIIPNYALKEVIEKFLDDNPWAKYEPGGMV