wanglab/gogpt-training-data huggingface dataset:
Protein: Protein CLP1 homolog (Crowded by cid) (Q7K284)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
Interaction partners:
- Pre-mRNA cleavage complex 2 protein Pcf11
- Cleavage stimulation factor 64 kD subunit
- Protein suppressor of forked
- Factor interacting with poly
- LD44919p
- Cleavage and polyadenylation specificity factor subunit 4
- tRNA splicing endonuclease subunit 54
- Cleavage and polyadenylation specificity factor 73
- YTH domain-containing protein 1
- Probable cleavage and polyadenylation specificity factor subunit 2
Sequence:
MSEDQGKDYTLESDSELRFEIEQKDAKVLVSLVSGFAELFGTELVKKKQYEFGVGAKVAIFTYQGCVLHVSGKMDVCYISKETPMVQYVNCHAALEQFRMEAEEKDRYGPVAMVVGPMDVGKSTLCRILLNYAVRVGRRPLYADLDVGQGSIAISGSVATILIERPANVEEGFAKTAPLVYHFGHKSPSGNSVLYNAVVSKMAEVTLQSLNSNKRTKSSGIIINTCGWVKGSGYAHLLHAAKAYGACAIFVLDQERLYNELLRDVPKGVHVVLLPKSGGVVERSKELRHEARDQRIKEYFYGNTRAPFYPFSFEVKFQDLRLYKIGAPPLPDSCMPIGMKAEDNKTKVVAVTPTPALIHHVLALSFAESVEDDVIGTNVAGFCCVTEVDMERQAVMLLSPQPRPLPPNALLLWSELQFMDNHT
Protein: Two-component response regulator ARR4 (Response regulator 1) (O82798)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling. Modulates red light signaling through its interaction with the phytochrome B photoreceptor.
Subcellular location: Nucleus {ECO:0000269|PubMed:27274065}.
Interaction partners:
- Phytochrome B
- Histidine-containing phosphotransfer protein 3
- Histidine-containing phosphotransfer protein 1
- Histidine kinase 4
- Histidine-containing phosphotransfer protein 5
- Histidine kinase 3
- Histidine kinase 2
- Histidine kinase 5
- Auxin-responsive protein IAA3
- Auxin transporter protein 1
Sequence:
MARDGGVSCLRRSEMMSVGGIGGIESAPLDLDEVHVLAVDDSLVDRIVIERLLRITSCKVTAVDSGWRALEFLGLDNEKASAEFDRLKVDLIITDYCMPGMTGYELLKKIKESSNFREVPVVIMSSENVLTRIDRCLEEGAQDFLLKPVKLADVKRLRSHLTKDVKLSNGNKRKLPEDSSSVNSSLPPPSPPLTISPESSPPLTVSTESSDSSPPLSPVEIFSTSPLSSPIDDEDDDVLTSSSEESPIRRQKMRSPGLD
Protein: Small integral membrane protein 1 (B3DHH5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Regulator of red blood cells formation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:B2RUZ4}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:B2RUZ4}.
Interaction partners:
Sequence:
MESNGASVQYNRWSEDNITLQEPQSRSRLLGIYNRVFTGRLVIMFKIAASLTVMVVMYIAGYITGFYVHQCG
Protein: Sodium channel regulatory subunit beta-1 (B3F0A3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Perikaryon {ECO:0000256|ARBA:ARBA00004484}.
Interaction partners:
Sequence:
MQECVRHLLILCVFCTLLVCVCRGACAEVDSDTEAVAGQGFTLGCISCKMRGEVEATATVDWLFRARGEADFVHIYTYDGSSENIIDERFLDRLEWHGSRNTLDLQDASVDITNVTFNDSGVFRCVFNRVLIYEHYEFSKVTSKDVHLTVVAKATRGTASIVSEVMMYVSIIGLQLWLLVEMIYCYRKIAAAGEEALRASAAEYLAIASESKDNCAGVQVAE
Protein: Dimethylallyl tryptophan synthase (Q2UG12)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- Beta-cyclopiazonate dehydrogenase
Sequence:
MEISKKAATLLPKPFYVLSQALNLSNKDHTKWWYSTAPMFATMMAGAGYDVHAQYKFLCIHREVIIPALGPYPEKGQPMHWKSHLTRFGLPFELSFNYSKSLLRFAFEPLGSLTGTKDDPFNTQAIRPVLQDLKAMVPGLDLEWFDHFTKALVVSEEEARTLLDRDIEIPVFKTQNKLAADLEPSGDIVLKTYIYPRIKSIATGTPKERLMFDAIKAADKFGKVATPLAILEEFIAERAPTLLGHFLSCDLVKPSESRIKVYCMERQLDLASIEGIWTLNGRRNDPETLDGLDALRELWQLLPVTEGLCPLPNCFYEPGTSPQEQLPFIINFTLSPKSALPEPQIYFPAFGQNDKTIAEGLATFFESRGWGGLAKSYPADLASYYPDVDLQTANHLQAWISFSYKGKKPYMSVYLHTFEAFSAAAQEVAMCHDGHNP
Protein: Ionotropic receptor 52c (A1ZA16)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MVWLIIILFCLGNSSSQILDVTNNSHLDFDYRLFGLLQRLQVEKSYDTLLVYGEDCAIPSLFERLQVPAVLVSSGSTNFDWNFSSLTLILSCNFQDEREENYRTLMKLQTSRRLILLKGHIKPESVCDFYSKKEQHNVAMVKENFYQLEVVYSCRLFQDQNYEKLNLFDGKSIYKDQFRNMHGAPIRTLSDKEPPRTIPYIDSKTGEEKFKGYVGMLISQFVKKVNATMQIREDLIKDDEEVSFVDITNFTSNDILDIGICEARTLEMSNYDAISYPYLMSSYCFMAPLPDSLPFSDVYMAIVAPSILIMFLIIFCICSVLIIYIQERSYRSLTIRSVLMNDICLRGFLAQPFPFPRQYNRKLKLIFMLVCFSSLISTTMYTAYLQAFLWGPPIEPRLTSFDDVKKSRYTMAINIYEREFLEALNVSLEDVEIYDYGKFSKLRSTFNTNYLFPVTALQWFTINEEQKLFKYKIFYYCDAFCLNQFDILSIPLRRHLPYRDIFEEHMLLQKEFGLTKYWIDQSYRDMIRANLTTFKDFSPLLENDYIEVHNLYWVFTMYFVGMGMGLCFFILEILRPLRYWRNCKIKCEYCYAFLKNFAK
Protein: VP2 (Q5MJR2)
Organism: Avian infectious bursal disease virus (IBDV) (Gumboro disease virus)
Subcellular location: Virion {ECO:0000256|ARBA:ARBA00004328}.
Interaction partners:
Sequence:
QTQQIVPFIRSLLMPTTGPASIPDDTLEKHTLRSETSTYNLTVGDTGSGLIVFFPGFPGSIVGAHYILQSNGNYKFDQMLLTAQNLPASYNYCRLVSRSLTVRSSTLPGGVYALNGTVNAVTFQGSLSELTDVSYNGLMSATANINDKIGNVLVGEGVTVLSLPTSYDLGYVRLGDPIPAIGLDPKMVATCDSSDRPRVYTITAADDYQFSSQYQSGGVTITLFSANIDAITSLSVGGELVFQTSVQDLVLGATIYLIGFDGTAVTTRAVAANNGLTAGTDNPIPFNLVFPTNEITQPITSIKLEIVTSKRGGQTGDQMSWSASGSLAVTIHGGNYPGALRPVTLVAYERVATGSVVTVAGVSNFELIPNPELAKNLVTEYGRFDPGAMNYTKLILSERDRLGIKTVWPTREYTDFREYFMEVADLNSPLKIAGAFGFKDIIRAIRRIAVPVVSTLFPPAAPLAHAIGE
Protein: Exported protein 2 (Q8IKC8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Heat shock protein 101
- Translocon component PTEX150
- Thioredoxin 2
- Translocon component PTEX88
Sequence:
MKVSYIFSFFLLFFVYKNTNTVVCDNGYGDLAATSALTTVIKDPISLTIKDIYEHGVKNPFTKIIHKLKKFIRYRKVLRWSRMWWVLLVREIVGDNTIEKKTEKALREIWDQCTIAVYNNTLNAVESKPLLFLHGILNECRNNFATKLRQDPSLIVAKIDQIIKSQIYRFWVSEPYLKIGRSHTLYTHITPDAVPQLPKECTLKHLSSYMEEKLKSMESKKNIESGKYEFDVDSSETDSTKDDGKPDDDDDDDDNFDDDDNFDDDTVEEEDASGDLFKNEKKDENKE
Protein: Ribosomal protein S6 kinase B2 (A0A8I6AFY6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAVFDLDLETEEGSEGEGEPEFNPADVCPLGELRAAGLETVGHYEEVELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGSHYIALAGLELTT
Protein: glutathione transferase (EC 2.5.1.18) (A0A384P5J0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
Protein: Dynamin-1 (EC 3.6.5.5) (Dynamin) (Q08DF4)
Organism: Bos taurus (Bovine)
Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q05193}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q05193}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P21575, ECO:0000250|UniProtKB:P39053}. Presynapse {ECO:0000250|UniProtKB:P21575}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000269|PubMed:11959911}. Note=Associated to the membrane in a helical polymer shape in a GTP bound state. Transiently recruited to endocytic clathrin-coated pits (CCPs) at a late stage of clathrin-coated vesicle (CCV) formation. {ECO:0000250|UniProtKB:Q05193}.
Interaction partners:
- Src substrate cortactin
- Mitochondrial fission 1 protein
- Hematopoietic lineage cell-specific protein
- Dynamin-3
- Amphiphysin
- Dynamin-2
- Intersectin 2
- SH3 domain containing GRB2 like 2, endophilin A1
- Clathrin heavy chain 1
- Intersectin-1
Sequence:
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDLAFEATVKKQVQKLKEPSIKCVDMVVSELTATIRKCSEKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKASGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPTGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSQPIGSGKSIPS
Protein: RRM domain-containing protein (D5MCP9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLQRMQYPQVYQSYYGYHPAAVYQQHYDVNSLASQMGGMHVGGGNPQANGGGDMYGAHMYGQNAGGQGGQGVGQGGQGGNQQFYNPNNGRNKKPMNPQ
Protein: Nucleophosmin (Q566X7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
RLTGPVRAKMEDNIKDLSRPQMYLFGCSLKGDKKEHKVDLDDDEAEHQLSLKSVCLGAEAEDKFHTVETEGLTYDGKTTKITLAVLKPSVLPSLSLGGFEVTPPVSFRLQSGGGPVYISGQHFVSVKESDDEDEEEEENNTSPVKRPSNMTLAKVPQKKLKMDSDEDEDSDDDDDDDDDDDDDEEDDDKQEKPAVKSPVKSTQKTPEKKKSADKQNGSPDKKAGTSGKPQTQTPQKVKDKSAAGPSGKTPSIPSLSEVKSKLTSAAKEGKPFPKTEQKFENFARSSFKISDKQVIKDLWNFVQSLKK
Protein: 5-methylthioadenosine/S-adenosylhomocysteine deaminase (MTA/SAH deaminase) (EC 3.5.4.28) (EC 3.5.4.31) (A3DEQ2)
Organism: Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)
Function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Interaction partners:
- Purine nucleoside phosphorylase
- Polyamine aminopropyltransferase
- Purine nucleoside phosphorylase
- Adenosylhomocysteinase
- Flagellar hook-associated protein 1
- Flagellar hook-associated protein 1
- Cell division protein ZapA
Sequence:
MNILIKNADIITCNASDDVLQGAFLGIKDGYIDFIDTKEDALKDFKADRIIDAKGKLVMPGLVNAHTHSGMTILRNFANDLALEDWLFGNVLPVEEKLTPEDIYWGTLLGIAEMIKSGTTTFADMYLHMEEVARAVSETGIRANLCRSPLKDSDKSVEDAVRCFEYFKKWDNSFNGRIKVYIEVHSVYLFDEPSLRMSAEVAKEINTGIHIHVQETLKECEDSNKKYGMSPAEICCKTGIFDVPVIAAHCVHLSDGDMGIIRDKGVNVIHNPTSNLKLGSGIAKVDDMLKNGINVALGTDGAASNNNLNMFEEMHLAALIHKGVHMDPTLIGASCALKMATVNGAKALGFGGEIGEISKGMKADLILIDMDKTHLCPVNDPVSAVVYSAQSSDVDTVIIDGNIVMENRELKTIDEEKVKFNVKEIAKRVLR
Protein: Late embryogenesis abundant protein At3g53040 (LEA domain-containing protein At3g53040) (Q9LF88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function in the proximal abscission zone cells to prevent water loss after floral organ shedding (Probable). May be involved in the reestablishment of desiccation tolerance in germinated seeds (Probable).
Interaction partners:
- Late embryogenesis abundant protein
- Late embryogenesis abundant protein
- AT1G27990 protein
- At2g23110
- Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 8
- Reticulon-like protein B13
- SNF1-related protein kinase regulatory subunit gamma-like PV42b
- Oleosin
- Late embryogenesis abundant protein 18
Sequence:
MASGQREAERSAKAERAEAAASLAAEDLKDINKGDVTYKLTERTTTTEPERPGLIGSVMKAVQGTKDAVIGKSHDTAESTREGADIASEKAAGMRDTTGEVRDSTAQKTKETADYTADKAREAKDKTADKTKETADYAAEKAREAKDRTADKTKETAEYTAEKAREAKDKTADKLGEYKDYTAEKAKEAKDTTAEKLGEYKDYTVDKAKEAKDKTAEKAKETAEYTSDKARETKDKTAEKVGEYKDYTAEKAKETADKAREAKDKTAEKVGEYRDYTAEKATETKDAGVSKIGELKDSAVDTAKRAMGFLSGKTEETKQKAVETKDTAKEKMDEAGEEARRKMEEMRLEGKKLDEDASRKTQQSTESAADKAHETKDSVAQRGEEGKGSIMGALGNMTGAIKSKLTGATTPSDEETRASAHGDESTGKTVVAVDVKDTRPGYVATVLKEADQMTGQTFNDVGEIDDEEKVRIVVGEKKL
Protein: Phosphoinositide phosphatase SAC8 (AtSAC8) (EC 3.1.3.-) (Protein SUPPRESSOR OF ACTIN 1A) (AtSAC1a) (Protein SUPPRESSOR OF ACTIN 8) (Putative transmembrane protein G5p) (AtG5) (SAC domain protein 8) (SAC1-like protein AtSAC1a) (Q96328)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12713536}; Multi-pass membrane protein {ECO:0000269|PubMed:12713536}.
Interaction partners:
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2B
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C
- Phosphatidylinositol 4-kinase alpha 1
- Phosphatidylinositol 4-kinase alpha 2
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
- Phosphatidylinositol 4-kinase beta 2
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D
- Phosphatidylinositol 4-kinase beta 1
- 1-phosphatidylinositol-3-phosphate 5-kinase FAB1B
Sequence:
MEIAPSTSRFKLYDQFELLEFPDKYVVKPIESPEEGFSVNRRDGNIKPLDENASSGSPTRVSTIYGVGGTIRLLAGTYLLVITSREEVGNFLGLPIFRVTAMKFLPCNEALRFATAQEKKDETYFRTLLQALETTPGLYFSYETDLTLNLQRRCKLAEGWNRKPMWKQADPRYVWNWHLLEDLIECKLDGFIIPILQGSYQVAELKLKNSPAVVSIMSRRCTRRLGTRMWRRGANLEGDAANFVESEQIVEINGFKFSLLQVRGSIPLLWEQIVDLSYKPRLKINKHEETPKVVQRHFHDLCQRYGEIMAVDLTDQHGDEGALSKAYATEMEKLPDVRYVSFDFHQVCGTTNFDNLGVLYEQIGDEFEKQGYFLVDADENILEEQKGVIRSNCIDCLDRTNVTQSFMGQKSLNLQLQRIGVCDSTECISTFEDDYTKFRTIWAEQGDEVSLQYAGTYALKGDLVRYGKQTMTGAIKDGLSAMSRYYLNNFQDGVRQDALDLISGRYTVGTHSPSQLQPIGSQPSFLPVASALLIGGVTVTSFTIHQAGRNTQQYLASALWAGVTAGVVAMIKANGRHLTSRPRLCHLI
Protein: Sphingomyelin phosphodiesterase (EC 3.1.4.12) (EC 3.1.4.3) (Acid sphingomyelinase) (ASMase) [Cleaved into: Sphingomyelin phosphodiesterase, processed form] (Q04519)
Organism: Mus musculus (Mouse)
Function: Converts sphingomyelin to ceramide. Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly. However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form (By similarity).
Subcellular location: Lysosome {ECO:0000250|UniProtKB:P17405}. Lipid droplet {ECO:0000250|UniProtKB:P17405}. Secreted {ECO:0000269|PubMed:8702487}. Note=The secreted form is induced in a time- and dose-dependent by IL1B and TNF as well as stress and viral infection. This increase of the secreted form seems to be due to exocytosis of the lysosomal form and is Ca(2+)-dependent. Secretion is dependent of phosphorylation at Ser-506. Secretion is induced by inflammatory mediators such as IL1B, IFNG or TNF as well as infection with bacteria and viruses. {ECO:0000250|UniProtKB:P17405}.; SUBCELLULAR LOCATION: [Sphingomyelin phosphodiesterase, processed form]: Secreted, extracellular space {ECO:0000269|PubMed:35705808}. Note=This form is generated following cleavage by CASP7. {ECO:0000269|PubMed:35705808}.
Interaction partners:
- Sphingomyelin phosphodiesterase 2
- Sphingomyelin phosphodiesterase 3
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Lysosomal acid glucosylceramidase
- Ceramide glucosyltransferase
- Ceramide kinase
- Phosphatidylcholine:ceramide cholinephosphotransferase 2
- Ceramide synthase 2
- Sphingomyelin phosphodiesterase 4
- Ceramide synthase 5
Sequence:
MPHHRASSGQDHLRAGWEQRLERSLPAPRVGLLWMGLGLALVLALFDSTVLWVPARAYPLPSEGHSVKFSAIAPPLQSAFGWQNLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPNGSLPDANRLWSRPLLC
Protein: Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (mLAT2) (Solute carrier family 7 member 8) (Q9QXW9)
Organism: Mus musculus (Mouse)
Function: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28108384, ECO:0000269|PubMed:29355479, ECO:0000269|PubMed:31231240}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UHI5}. Basolateral cell membrane {ECO:0000269|PubMed:10574970}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UHI5}. Note=When coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. {ECO:0000250|UniProtKB:Q9UHI5}.
Interaction partners:
- Amino acid transporter heavy chain SLC3A2
- Large neutral amino acids transporter small subunit 4
- Large neutral amino acids transporter small subunit 3
- Amino acid transporter heavy chain SLC3A1
- Monocarboxylate transporter 10
- Neutral amino acid transporter B
Sequence:
MEKGARQRNNTAKNHPGSDTSPEAEASSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGIITAVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEFFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANIAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCLSTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKVSLLFPIIYLLFWAFLLIFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFNDFIKSLTLVSQKMCVVVYPQEGNSGAEETTDDLEEQHKPIFKPTPVKDPDSEEQP
Protein: Calcium uniporter protein, mitochondrial (DdMCU) (Q54LT0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:24889638}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- EF-hand domain-containing protein
- Inositol 1,4,5-trisphosphate receptor-like protein A
Sequence:
MNSFVIRNGFGLVRTFNTRLFTTSTQNLEGELKTILGQAKVSKLQEKLKLDPRSKITFNDFKGIAKEVGIEEKEINSVSNALAQSGSIIYLPNSLNENLKTSVFTKPAHIYQSLEHILDIENKGVGLNKLIESKKSEINSLRQKIQPLEEKKQVIDRKAHRRATAIIWTGLGYCFAQAAILARLTWWDLSWDIIEPVSYFLTFGSVLIGYTYFTMTKTEFTYEALNHRLFSKRQDKLFKRNNFPKEDYENLVQAIDKKEKELKELELATKYDHTH
Protein: Arrestin family protein 1 (O42956)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in cytokinesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Rho1 guanine nucleotide exchange factor 3
- Rho1 guanine nucleotide exchange factor 2
- Rho1 guanine nucleotide exchange factor 1
- Meiotically up-regulated gene 170 protein
- Uncharacterized protein C557.05
- GTP-binding protein rho1
Sequence:
MTSPCTLIRQFSPLEIRPLPHLDFQAGFNGIPTSAPRLVGIVQVRSKEIHQPLALVQITLELWKIESVVIPSLGISNHLSDNKCLARQVLFPLHSEHPENNIPPNDNNYSISDLSIKSPPPSLTSDWIVDSYASDQDNPSVHTHNRTTPPIPPPHLPNASGSSVYQPPYTPFRSVSTTSSSNDTSITPFGDQTPILSSSSDPYATHRVWSMDLPFEIPFPENSEIPSTFELNRSGTICSTKYELRAHMSLLGVPDITTTVPVSLSRYDNLSSWGMYNSPTNIRQVSSDGRVVVEVSIPKLCIGPSDLVSVFVSIMPNNGSKIRVQQLSLSLVEYITFIHPSSSSPIVRKKKVLRYEEDLDDMKLTSEGLSKSLSKPFPDIDFEDANITGFTTTSDLYSVQYMLVIKVQLYRARNIEITNPIIVSPVERSRSQALLNEIQTRVLDVRQSHGGVVLEENVRIVRASDFSKNNMFAYLNDDIVLLS
Protein: PppA (Q9I757)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- non-specific serine/threonine protein kinase
- Type VI secretion system-associated protein TagF
- Type VI secretion system component TssM1
- AAA+ ATPase ClpV1
- Type VI secretion system spike protein VgrG1a
- Fha1
- Sulfatase-modifying factor enzyme-like domain-containing protein
- Probable ATP-binding component of ABC transporter
- Glycine zipper domain-containing protein
- Type VI secretion system baseplate component TssK1
Sequence:
MVPNSVSYYRSASYSHVGMVRKVNEDASLDAPEAGLWVVADGMGGHAAGDFVSSLIVDTLRRIPAASSLPAYVGALRTGLAQVNERVRQEAGLRGVSVMGSTLVLLAARGNQASCLWAGDSRLYRLRGGVLEAISRDHSYVQELLDNALISEEEARHHPRANVVTRAVGVHEQLELSEAALHVLPGDSFLLCSDGLNKTADDSELRDVLSHSDPYAVVRSLVHLGLTRGAPDNITALVVRAF
Protein: Sperm motility kinase 1 (EC 2.7.11.1) (Q9QYZ4)
Organism: Mus musculus (Mouse)
Function: May play a role in sperm motility, especially in the regulation of flagellar function.
Interaction partners:
Sequence:
MEKFHAQYEMLETIGQGGCAKVKLARHRLTGTHVAVKMIPKREYWCKLLMFEAELLMMFNHPNIISLLQVIETKKKVYLIMELCEGKSLYQHIQNAGYLQEDEARPLFKQLLSAMNYCHNQGIVHRDLTPDNIMVEKDGRVKNIDFGLSTHVKPGQKLNLFCGTYPFSAPEVLLSRPYGGPKIDVWTLGVVLYFMVIGKIPFDAASIEKLRKQIVAGKYSAPCRLSVKLQHLINLLMTDNPELRPTVAEVMVHPWITKGSGVFPDPCEEQIPLKPDPAIVKPMGHIGFQAQDIEDSLRQRKFNETMASYCLLKKQILKECDRPIRDQPMNPSVTPFPSLVDTPTFHLGLRRRETEPTGLRLSANRQVSVCGKSTSKKRDRSFIWPGVLSRPINTTPTMDQTHTRTRSVPCIYSNVCTIHPNSIDESTEGHTSASAEDKPVHSRGWPRGIKGWTRKIGNAMRKLCCCIPSKETSHLGQSRVCPKK
Protein: Sorting nexin-32 (Sorting nexin-6B) (Q86XE0)
Organism: Homo sapiens (Human)
Function: May be involved in several stages of intracellular trafficking.
Interaction partners:
- Sorting nexin-2
- Sorting nexin-1
- Sorting nexin-6
- Sorting nexin-5
- Sorting nexin-7
- Sorting nexin-8
- Sorting nexin-4
Sequence:
METYAEVGKEGKPSCASVDLQGDSSLQVEISDAVSERDKVKFTVQTKSCLPHFAQTEFSVVRQHEEFIWLHDAYVENEEYAGLIIPPAPPRPDFEASREKLQKLGEGDSSVTREEFAKMKQELEAEYLAIFKKTVAMHEVFLQRLAAHPTLRRDHNFFVFLEYGQDLSVRGKNRKELLGGFLRNIVKSADEALITGMSGLKEVDDFFEHERTFLLEYHTRIRDACLRADRVMRAHKCLADDYIPISAALSSLGTQEVNQLRTSFLKLAELFERLRKLEGRVASDEDLKLSDMLRYYMRDSQAAKDLLYRRLRALADYENANKALDKARTRNREVRPAESHQQLCCQRFERLSDSAKQELMDFKSRRVSSFRKNLIELAELELKHAKASTLILRNTLVALKGEP