wanglab/gogpt-training-data huggingface dataset:
Protein: Peroxisomal acyl-coenzyme A oxidase 1 (AOX 1) (EC 1.3.3.6) (Long-chain acyl-CoA oxidase) (AtCX1) (O65202)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the desaturation of both long- and medium-chain acyl-CoAs to 2-trans-enoyl-CoAs. Most active with C14-CoA. Activity on long-chain mono-unsaturated substrates is 40% higher than with the corresponding saturated substrates. Seems to be an important factor in the general metabolism of root tips. May be involved in the biosynthesis of jasmonic acid.
Subcellular location: Peroxisome {ECO:0000255}.
Interaction partners:
- Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2
- Peroxisomal fatty acid beta-oxidation multifunctional protein AIM1
- 3-ketoacyl-CoA thiolase 1, peroxisomal
- 3-ketoacyl-CoA thiolase 2, peroxisomal
- 3-ketoacyl-CoA thiolase 5, peroxisomal
- Probable enoyl-CoA hydratase 1, peroxisomal
- Probable acyl-CoA dehydrogenase IBR3
- Acetyl-CoA acetyltransferase 1
- Acetyl-CoA acetyltransferase 2
- Peroxisome biogenesis protein 5
Sequence:
MEGIDHLADERNKAEFDVEDMKIVWAGSRHAFEVSDRIARLVASDPVFEKSNRARLSRKELFKSTLRKCAHAFKRIIELRLNEEEAGRLRHFIDQPAYVDLHWGMFVPAIKGQGTEEQQKKWLSLANKMQIIGCYAQTELGHGSNVQGLETTATFDPKTDEFVIHTPTQTASKWWPGGLGKVSTHAVVYARLITNGKDYGIHGFIVQLRSLEDHSPLPNITVGDIGTKMGNGAYNSMDNGFLMFDHVRIPRDQMLMRLSKVTREGEYVPSDVPKQLVYGTMVYVRQTIVADASNALSRAVCIATRYSAVRRQFGAHNGGIETQVIDYKTQQNRLFPLLASAYAFRFVGEWLKWLYTDVTERLAASDFATLPEAHACTAGLKSLTTTATADGIEECRKLCGGHGYLWCSGLPELFAVYVPACTYEGDNVVLQLQVARFLMKTVAQLGSGKVPVGTTAYMGRAAHLLQCRSGVQKAEDWLNPDVVLEAFEARALRMAVTCAKNLSKFENQEQGFQELLADLVEAAIAHCQLIVVSKFIAKLEQDIGGKGVKKQLNNLCYIYALYLLHKHLGDFLSTNCITPKQASLANDQLRSLYTQVRPNAVALVDAFNYTDHYLNSVLGRYDGNVYPKLFEEALKDPLNDSVVPDGYQEYLRPVLQQQLRTARL
Protein: Uncharacterized protein (Q585E0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYLSSAFFPTHVLFHYSRSHQHEHRNGRNSSNNSTEGQKENKSGKAGKLSVRLRLGKQSAEGCGVGLDMSRALERLLPTLVKHLVGEVVENDDWEADTTTYEGAEVKAEVEAEEKLLTAQREHENDGNGVCSTKASLNATSFSNKGSSACSSAQRWRRCIEIWRHLLGSDQLFLALLFHSGSLWAKEWSPGKQGGEILETPGPTAGAGTNSSWVEAVLWFLQLHEIPAATDSEEGGDDNKTSFVHSDEKVTEKAEFGNVCGAPSAFHIRSKERTQVQRAATGLLGDWFATVDKCGKRFARAYYFSCAIKIVALVGNATLIESIPHLHNLVQMDPRFSSHLKAFCSILCCLLVEEAQQQQPYRLRLPPPFFLLNFNLIGRGSRVGVWLPRALTGYRGAGKSTQEGDFYSCVVSCSGVVLRMPSSPPTSQGAGDIVLVVRLLDEAHMGSNDVLPLLPRTSRSSQDDERLQEKWVGRARRHAVHGSLHAGGTSPLRCWSAMCAATCSFVRIDVAESRRIVELLPPTTTAAANNNNRRAPIHQQQQQQGPTLFTVPLQRGSRASVGRDPLAAITFTLSTTARRLIGCRGLFTKQQSVHERKSNGHLSRVEKSNTNAHYPVSRFTTDAASCGDTLGAPCSAFFSRSEEELECLIECALHLQLEALLLCSTLPRDIFPVVDAWAVEATSNAIDLALATPWPVVRCLRASGFALCLMPEHQQHQSLLVAIGLFATLVQRQKERKSDRSAATGAAPYDGAANASSGAGWWEVFKVCVLGDTVIPGQFCSGFWKLVERAERSFRTSPSVRLVKKQGQSVDVDSSGVEASESPPTHGLERGPPRRLSLRRSKQQRGENVGQGDGEGGEKKICKVETMGSHRELTPFATLRFVTPRTVEVFDDYPLTSRSHSTENRRQITLTDMAVSLWWVLEQTAANIASG
Protein: phospholipase D (EC 3.1.4.4) (Q59EA4)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037868}; Lipid-anchor {ECO:0000256|ARBA:ARBA00037868}.
Interaction partners:
Sequence:
ANAQVLAAPSPCSPFAFTLSKVNMSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSAIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSNTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT
Protein: Peroxisomal leader peptide-processing protease (EC 3.4.21.-) (Trypsin domain-containing protein 1) [Cleaved into: Peroxisomal leader peptide-processing protease, 10 kDa form; Peroxisomal leader peptide-processing protease, 49 kDa form] (Q9DBA6)
Organism: Mus musculus (Mouse)
Function: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids (By similarity).
Subcellular location: Peroxisome {ECO:0000269|PubMed:17255948}.
Interaction partners:
- Lon protease homolog 2, peroxisomal
- 3-ketoacyl-CoA thiolase A, peroxisomal
- Peroxisomal membrane protein PEX14
- Peroxisomal multifunctional enzyme type 2
- Sterol carrier protein 2
- Alkyldihydroxyacetonephosphate synthase, peroxisomal
- Phytanoyl-CoA dioxygenase, peroxisomal
- Peroxisomal targeting signal 1 receptor
- Peroxisome biogenesis factor 10
- Peroxisomal acyl-coenzyme A oxidase 1
Sequence:
MGRQWGPSMRVAEQAGCVVSASRAGQPDAGSWSCSGVILSRNPGLVLCHGGIFTPFLRTGSAALTQTGTAFLPGDSCSDDLRLHVQWGPTAASPAGRADQELPGLCTPQCASLGLEPGAPSRARARPLQPPRPAQLLLLLSCPAFRSHFARLFGADAVDQWHFVSSAPDDAVSEEEEEDQLRALGWFALLRVQRGAAAEERRGPVVTVAPLGAVVKGAPLLACGSPFGAFCPDIFLNTLSRGVLSNAAGPLLLTDARCLPGTEGGGVFAARPAGALVALVAAPLCWKAREWVGLTLLCAAAPLLQVARWALARLHPGSASLSVLLPPPDVSTPRGLPLRDLGPPWAAAAVLVECGTVWGSGVVVAPRLVVTCRHVAPREAARVLVHSATPKNVAIWGQVVFATQETSPYDIAVVSLEEELNGVPTPVPAGHFHEGEPVSVVGFGVFGQACGPSVTSGILSAVVRVDGSPVMLQTTCAVHGGSSGGPLFSSGSGDLLGIVASNTRDNNTGATYPHLNFSIPITVLQPALKQYSQTGDLGGLRELDHTTEPVRVVWRLQRPLSEVPRSKL
Protein: Metallothionein-2 (MT-2) (Metallothionein-II) (MT-II) (P02798)
Organism: Mus musculus (Mouse)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Interaction partners:
- Metallothionein-1
- Metallothionein-3
- Proton-coupled zinc antiporter SLC30A1
Sequence:
MDPNCSCASDGSCSCAGACKCKQCKCTSCKKSCCSCCPVGCAKCSQGCICKEASDKCSCCA
Protein: GCMb (Glial cell missing-like protein) (Glial cells missing homolog 2 (Drosophila)) (Glial cells missing transcription factor 2) (Q68BU9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Forkhead box I3b.
- Forkhead box I3a.
- Forkhead box N1
- Sodium/hydrogen exchanger
- Solute carrier family 12 member 10, tandem duplicate 2
- Transient receptor potential cation channel subfamily V member 6 isoform X1
- Parathyroid hormone 1a.
- Cleavage and polyadenylation-specific factor 4.
- Anion exchange protein
- Calcium-sensing receptor.
Sequence:
MSKSSDQFDSSDCVCSFGMKLTWDINDPKLPQDTKQYDAFQEWTDGYVRYIYSSEDKNAQRHLSGWAMRNTNNHNCQILKKSCLGVVVCSRNCSLPDGSKLQLRPAICDKARQKQQKKLCPNCNSALELIPCRGHSGYPVTNFWRVDGKAIFFQAKGVHDHPRPESKSETEARRSAVKRRMSSPPFSQKRRLVEPEPGRYHDMAFPNIHQLTMEGPERFSIIAESNFPIQTQHYPTFQNPEPYKFPYDTHAAAMADAQSSLQKPANHRLYVTRPPCGYDFAVPGYLGSGPYPAALYKDPSSPQMETEPNKSGSSLSGVSHGSSPLGSHERSYAESSGKHHGWKQILSKGGYGDRGDYSQLPTNANHHYYNSDYPCRYTGPAAPTPAALQTIITTTTKVSYQPCPKPSVVKYGENIYDVKGLSNCNSILEEPSPNSYSDLKIPEDSGVIKSALSYQDTLPAKIERSENFEGYRYSSYSANSYPERMSHPFRYDSGEY
Protein: Protein male-specific 40 (Q24437)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8013257}. Nucleus {ECO:0000269|PubMed:8013257}.
Interaction partners:
Sequence:
MFKPGYSEAKKPKITDEFSYKQT
Protein: Protein artemis (mArt) (EC 3.1.-.-) (DNA cross-link repair 1C protein) (SNM1-like protein) (Q8K4J0)
Organism: Mus musculus (Mouse)
Function: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein likely exhibits single-strand specific 5'-3' exonuclease activity in isolation, and may acquire endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity may be required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-dependent protein kinase catalytic subunit
- X-ray repair cross-complementing protein 5
- X-ray repair cross-complementing protein 6
- DNA ligase 4
- Non-homologous end-joining factor 1
- DNA repair protein XRCC4
- DNA repair protein XRCC1
- DNA excision repair protein ERCC-5
- Serine-protein kinase ATM
- Breast cancer type 2 susceptibility protein homolog
Sequence:
MSSFQGQMAEYPTISIDRFDRENLKARAYFLSHCHKDHMKGLRAPSLKRRLECSLKVFLYCSPVTKELLLTSPKYRFWENRIITIEIETPTQISLVDEASGEKEEVVVTLLPAGHCPGSVMFLFQGSNGTVLYTGDFRLAKGEASRMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREQCLRGILELVRSWVTRSPHHVVWLNCKAAYGYEYLFTNLSEELGVQVHVDKLDMFKNMPDILHHLTTDRNTQIHACRHPKAEECFQWNKLPCGITSQNKTALHTISIKPSTMWFGERTRKTNVIVRTGESSYRACFSFHSSFSEIKDFLSYICPVNVYPNVIPVGLTVDKVMDVLKPLCRSPQSVEPKYKPLGKLKRARTIHLDSEEDDDLFDDPLPTPLRHKVPYQLTLQPELFSMKALPLDQPELRQSPGGCKAESVWSPSLANFIDCEESNSDSGEELETPPPSLQGGLGPSTLVQQNADPDVDIPQWEVFFKRRDEITGECLEHLPSSIETGGSQSPKLCSDSPKLCSDSPKLCSDSDGDSTHISSQNSSQSTHITDQGSQGWDSQCDTVLLSSQEKSGGDSTSLNKGAYKPKLKESISASQIEQDALCPQDTHCDLKSRAEVNGAPCLVELDTLSGRKSPPEKTLLSSTRADSQSSSDFEIPSTPEAELPTPEHLQCLYRKLATGQSIVVEKRKCSLLDS
Protein: HSPA8 protein (Q96IS6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
AMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
Protein: RE35509p (Uncharacterized protein, isoform C) (Q9VGG9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
Interaction partners:
Sequence:
MKRRSQTRAEQAVPPAKTTKENSGSLTVSQLSSDVIWQLASQYWTPDTKADHLPYSAKIIERIYNEEIGDGGGHSARRINMLEFSQYLEQYLWPHYQRETATHAHLMSIVIMANEKFRERVEVWTVFEKLPDQYPAFFRHVLESCLPSKKAKEASSTLRERTALLMFINHCFNSMEIELCREQAKRLVSLSMWHCLQPRRREQELREVPEWRKYWKRLLKKEKDSKPEVLWERHFMQNLIIDFLHILESIPAEGEVPRNVVHYCERFLEFIIDLEALLPTRRFFNTVLDDCHLIVRALLSPLVRREEGKLFGQLLDMLKFYTRFEINDVTGSSLTDHDMTQLHYKKITSLQRAVFAKFPSLRVFALSNVATVDNRESLEQHFGGLDGKGLLQIATFLNLVPEEVVSPLDWHRVDEQFLRELLITRHERRCSQLEALNEMPLYPTEQIIWDENVVPSEYYSGDSCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDAVSRMLPWKSEDGDVVFGGWARMALPIASFAVVEVAKPHLGEKKPSRVRADVGVTLSVRREIKAEWENLRKHDVCFLITVKPTQPYGTKYKHREPFVPQVGLVSVRGCEVEGMLDANGRVIEDGPEPRPQLQGENRCYRVWLDSNQYRLDMDDLQEGADDVYESFNILMRRKPKENNFKAVLETIRHLMNTECVVPPWLHDILLGYGDPGAAHYSNMPNQERSLEFNDTFMDYNHLEASFPQYNLKCEVPVENRQPPFRLIFEDVPIQKESDGEDPEEKPEEKLTKSILVQPYKYEARGPYPSDKPKQNSIRFTPTQVEAIRAGMQPGLTLVVGPPGTGKTDVAVQIISNIYHNHPNQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEALETEKDYSRYGRVNYVLAKRMDLLSQVQKLQEALGVSGDNAYTCETAGYFYLYNVMARWEKFQSQISVHKGEADAEKLRAEFEKEFPFGKFFADAPQPLFKGANYDELMDIACSNFRYISDIFNELEEFRAFELLRTGLDRSKYLLVKEAKIIAMTCTHAALKRKELVNLGFRYDNILMEESAQILEIETFIPLLLQNPLDGLNRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRLVRLGVPTVDLDGQGRARASICSLYKWRYKKLEDLQHIFERDEYKQANPGFVHDYQLINVEDFKGVGESEPNPYFYQNLAEAEYIVAVYMYMRLLGYPAAKISILTTYNGQKHLIRDVINARCGNNPLIGWPHKITTVDKYQGQQNDYILISLVRTKAVGHLRDVRRLVVAMSRARLGLYVFGRVSLFKNCLELQQTFKLRPLKLSLVPEDKFPTDRLASAAVASQDIKTVENMSEMAQFVYERYMAKMEELKGTLPSEEELEAMRNQLLQEDEESVPEASEEPPEKRAAKEEPLSKKKTTEAFKPTPILNEINVDDTEMGQREQIEEEATDQDKTQESAPAEES
Protein: Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) (P98194)
Organism: Homo sapiens (Human)
Function: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity. Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:21187401}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:21187401}; Multi-pass membrane protein {ECO:0000255}. Note=During neuron differentiation, shifts from juxtanuclear Golgi position to multiple Golgi structures distributed over the neural soma with a predominance in the apical dendritic trunk. {ECO:0000250|UniProtKB:Q80XR2}.
Interaction partners:
- Coagulation factor VII
- Cofilin-1
- Putative divalent cation/proton antiporter TMEM165
Sequence:
MKVARFQKIPNGENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVERSREKIQKHVSSTSSSFLEV
Protein: Transcription factor AP-2-epsilon (AP-2-epsilon) (Q6P0E7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6VUP9}.
Interaction partners:
- Odd-paired-like)
Sequence:
MLVHSYSSMERADGLSSSSPGGRLSQLNQAAYSSAPPLCHTPASDFQPPYFPPPYPQSSLSYSQSQDGGYPHLPEPYPSLNSLHQHQQAAWHSQRSRSEDAGLLSQPHRALSLDPRREYPGVPRLLTHGLGDGAAALGDGPLGMHAVHHGLDDIQGLEEASALGILDHSVIKKVPLPSKLNGSTISALSLSKEGLGLGGVSNPAEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLAPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLPAGRRKAANVTLLTALVEGEAVHLARDFGYVCETEFPARATAEYLCRQTEPDQLPTRRSMLLATKEICKEFVDLMSQDRSPLGASRPTPCLEPGVQSSLTHFSLLTHGFGTPALCAALSAFQSYLLEALKLLDKGENGGKNHHDKELKHRK
Protein: Kazal-like domain-containing protein (Q8BM18)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKTATVPMLLTLAFYLTQDAAGEKGNQDPCMKFQAQMKNGTLTCPKGNNSSQSLNDIIFQSECILCKRALEQGAPTKIMNVKVLSRANRATDPAKLNCESFKQRRKDGDFICPSDTSSVCGTDGKTYRSRCELCAENAKSQNHVDVKSEGECGSSHLETDMCSDFRAYVQDGRLGCTRESDPILGPDGRTHGNRCAMCAELFLKEAKENATRNRESRIRRDAEKELCKEFENQVRNGRLFCTRESDPIRGPDGKMHGNKCALCAEIFMRQFTEEKGKAEKNQKDAEERAKAKMEIQKRCSEFQDRARNGTLFCTRENDPIRGLDGKTHGNLCSMCQAFFKTEAEEKKAEAGSRNRRGSEESETYAKLCDEYRKARKNGQLYCTRENAPIRGPDGKIHGNTCSMCQAFFIQEDKARAKVKREAAKEMCSEFRNQARNGMLMCTRENDPVVGPDGKRHSNKCAMCASVFLLEEEEKKKDDKTEKVDAGKAKKEAVQELCRKYHTQLRNGPLRCTRRNNPIEGLDGKMYKNACFMCWAFFQQEAKKSGAGFRPKVKREVKVDCSEYLALSKRGEIFCTRENDPVRGPDGKTHGNKCAMCKAVFK
Protein: pyruvate decarboxylase (EC 4.1.1.1) (A6MUS9)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
AADGYARSRGVGACVVTFTVGGLSVLNAIAGAYSENLPLICIVGGPNSNDYGTNRILHHTIGLPDFSQELRCFQTVTCYQAVVNNLEDAHEMIDTAISTALKESKPVYISISCNLPAIPHPTFDREPVPFSLSPKLSNKIGLEAAVEAAAEFLNKAVKPVLVGGPKLRVAKACEAFVELADASGYAVAVMPSGKGLVPEHHPHFIGTYWGAVS
Protein: Carboxypeptidase Z (CPZ) (EC 3.4.17.-) (Q66K79)
Organism: Homo sapiens (Human)
Function: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10671522}.
Interaction partners:
- AF4/FMR2 family member 1
Sequence:
MPPPLPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY
Protein: RNA-binding protein, putative (Q382C7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQTCLLSNIPPCTEDELKRGLLAYGTTVSTVVVPHMRQAAVTMRTAQEAQALLQRGCISLFGQTVKVEPAASPAVPYGAGGISAGGMNNHLGGARINVVVEKCTYPVTKEVLSQVFSMVAPPANVVCGPSGPTTNGWVDYNDIATAQRVVVQLNNNSIYPDCCFMTLTLEHMGSTPRGMGEYGSQGHMPYHPQQPQHQNIHQNQQMSQQQLQAMPFGNNGFNAASARGGRGIRGRARGRGAMGGRGGPVYGSGYPMQHAPYAPGQYGAPPVDSVVIVNSVPETVALHSLWVLLEVYGNVNSLKRQFSSKTSVIAHFQNVHDARLAVQHLQGCPFHGATLTLRHFAGYVERGGKTEWNSGPATDPATQAVLFSCGYHHRTRPTASFNPTGRVRPGRYLFVSNLTEAITDDDLKDVFTNECFELDGYYRKSPTVAIVSLKDVETAVNALIAVHSHQLKERFLRVTFSHFPPAPRSGTEEEVEQALAATEAEAAEVREDVEPQDEQNE
Protein: X-prolyl aminopeptidase 1 (Q5T6H7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSETIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQKQGRQEALEWLIRETQPISKQH
Protein: NmrA-like family domain-containing protein 1 (I3L1Y8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
NIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAPDGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKVGLPPQMTPEDYEKLGFPGARDLANMFRFYALRPDRDIELTLRLNPKALTLDQWLEQHKGDFNLL
Protein: PLEKHG6 (A0A2X0TW08)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV
Protein: Resistin (Adipose tissue-specific secretory factor) (ADSF) (Adipose-specific cysteine-rich secreted protein A12-alpha) (Cysteine-rich secreted protein FIZZ3) (Q99P87)
Organism: Mus musculus (Mouse)
Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.
Subcellular location: Secreted {ECO:0000269|PubMed:11201732}.
Interaction partners:
- Toll-like receptor 4
- Adiponectin
- Leptin
- Nicotinamide phosphoribosyltransferase
- Adenylyl cyclase-associated protein 1
- Complement factor D
- Tumor necrosis factor
- Insulin-2
- Insulin-1
- Forkhead box protein O1
Sequence:
MKNLSFPLLFLFFLVPELLGSSMPLCPIDEAIDKKIKQDFNSLFPNAIKNIGLNCWTVSSRGKLASCPEGTAVLSCSCGSACGSWDIREEKVCHCQCARIDWTAARCCKLQVAS
Protein: Uncharacterized hydrolase C25B8.12c (EC 3.-.-.-) (Q9UTA6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative uncharacterized hydrolase C1020.07
- Small ribosomal subunit protein uS17m
- Putative thiosulfate sulfurtransferase, mitochondrial
- Small ribosomal subunit protein mS29
- Uncharacterized protein C15D4.13c
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein uL11m
Sequence:
MSAVDKTNNLPTLDTLQMVISDVDGTLLDKHHRFHFRTYRAMKYIREKYPNFPIVLATGKQRSAVDLIRIPLDLDAFPAAHVNGCVLYNKGKIVYADHLKPEVVMEVVEATKGNPNIANVVYDEHYVYALTPGREDMKNVKRLAEIGEKVDFSMPCEEAIEKVKSGEIKVIKMAVCEDPDKLDVVRDILGKFPREKFATTQALEFCIELIPSNSNKGTALQYITSNILPEVKNENVISFGDGQNDLSMFAIAGWSVAIKNGMPIAIEKAKAVSRVGNEEGAVGEVLERIFNIPEDYTPPPYTF
Protein: Homeobox protein dsc-1 (Defecation suppressor of clk-1) (Q93246)
Organism: Caenorhabditis elegans
Function: Transcriptional regulator which plays a role in the expulsion step of defecation by controlling enteric muscle-specific expression of exp-1 which is required for enteric muscle contraction. Not required for exp-1 expression in the PDA neuron. Also involved in controlling the length of the defecation cycle.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:16236771}. Cell projection, axon {ECO:0000269|PubMed:16236771}. Cytoplasm {ECO:0000269|PubMed:16236771}.
Interaction partners:
- Homeodomain-only protein
Sequence:
MNPHTNLNNVFDFPDLPMLLPKSEALSVTTDFSVPPVQQGAQQFHPPRNLGPQLARRWSCGDSQHADEPPASYYHNLGVALHNHFQMSNQHYLSDFDCPTTVSPISSAHETGQLPQLSPYDHIGNQDPHMFSPHAYGNSMIPDNSYFENASRSISAPNVGNSTLNPSLMSSDNAQSCGGRRRFRTNFTELQSTFLEDSFKESHYPDHKAKKYMADFLKIPEDRITVWFQNRRAKWRRKEHRQRDRTRNESFSGGSNSFDFACFSAQHPDDGPNAKHPNSFGIPNQPMSLDQFPMNTEQDFPEFPSLQEHQ