wanglab/gogpt-training-data huggingface dataset:
Protein: Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) (Q6IAA8)
Organism: Homo sapiens (Human)
Function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. Involved in the control of embryonic stem cells differentiation; together with FLCN it is necessary to recruit and activate RRAGC/RagC and RRAGD/RagD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity).
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:32686708}; Lipid-anchor {ECO:0000269|PubMed:31001086}; Cytoplasmic side {ECO:0000269|PubMed:31001086}. Late endosome membrane {ECO:0000269|PubMed:20544018}; Lipid-anchor {ECO:0000269|PubMed:31001086}; Cytoplasmic side {ECO:0000269|PubMed:31001086}. Note=Recruited to lysosome and endosome membranes through N-terminal myristoylation and palmitoylation. {ECO:0000269|PubMed:31001086}.
Interaction partners:
- Ras-related GTP-binding protein D
- Ragulator complex protein LAMTOR5
- Neutral amino acid transporter 9
- Ragulator complex protein LAMTOR3
- Ras-related GTP-binding protein A
- Regulatory-associated protein of mTOR
- Ragulator complex protein LAMTOR4
- Ras-related GTP-binding protein C
- Ragulator complex protein LAMTOR2
- Ras-related GTP-binding protein B
Sequence:
MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP
Protein: LD22578p (Q8MZ45)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}.
Interaction partners:
Sequence:
MGIRQLFMDIEGTKVIFIDDHSQGYVFLPVVEEALLIPDIPKQCLGCLWDLTQPNIFISYDARIVNTHVFVRHSVQGTHTLMVGESKLNPGQFPLLLCGGEMALHIDGGQYATQSLSTHVVNPSNSQAANLQMLLKLRNYDEAYKLCKQMNQSSAWREFGEQAISDLEPDIAIRAYRQLGDAALVNALSELRYVEDLDMLIGCCCTLLAQYDQAKEHMLKGVYTRAALDLCRDLLQWDQALLLAHKNDPQEVPYIAREYAQQLEFNGNYTDALYHYEKGYKEDLINSKETETDALMDSSPEYEEHVRLCKMGIARTSIRAGDFRRGIQYAVELEDQQLLFDCAELLATVGHLTEAAGLYERGGFYDEACGHYIALKMWNKANNILPKVKSTKLHAAYAKAKENDGHYEEAIRSYRIAGDLDACVRIYLDHLCDPHAASEIVLESRSMDSAKLLAKFYQKIGDVEQALQFLVICGCVEEAFALAQRHNKLRRHGELLERYENAKSSDYLALAHYFEGEKYTLLAGKYYFLAREFTKALRFLLKASAFNNEEQVSLSLAIDCVATSNNEQLATQLIEFLLGEVDGVPKDPRYLFRLYMARKHYKDAAKTAVIIANQEQIAGNYKSARDLLYSMYQELRRNNLSVTAEMRHQFILLHRYTLVRIHVKLGNHLLAAKLLVQVAACISQFPEHIIPILTSTVIECHRAGLKKSAFTYASTLMRPDYRNQLDPRYAKKIESIVRKAPKGIKQLRDEIDGETMECPICDSNLANMEVTCYSCKTTLPICIATGQHIIKQLMTSCPQCDFLCFRAEMENILSENGECPMCGENVAPEQLLDVEDIRPYILAAS
Protein: Protein GIS4 (Q04233)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in the Ras/cAMP signaling pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Activator of stress genes 1
- Serine/threonine-protein kinase SKS1
- Protein GIS3
- UPF0507 protein YML002W
Sequence:
MQKSVRVGDYFDNDDNGLWSWYLTNLRLGDFEELIGNQLKYTLLKRFLNSHFYGDNNISARPNKKILLVSIPENVHEDISILEIFLKDYFHLEKLEHIQISKLTHSHCYNHENHYLLTDNLNNFQDPTFLEFASTSWQVQKNSKALNNNNRNSIPPPTISSSKASNGKLESNVSDDQWSNINTQTSTATRTNTNTRTLTSPDTVDINVTSVNSQSNNNDTPQDNENEVDEEDATSSIVLNFSHSRTVDSKPNRLPKIFPSYTNEDYTPSHSEIMSIDSFAGEDVSSTYPGQDLSLTTARREDESGQDEVEDHYSRVSHDLGDESIDQASYSMESSVSYTSYSSSSNSSSAHYSLSSSSRGNPKRENIDHTNATYVSELSSITSSIDNLTTSTTPEEEDNLIHHNYDAQGYGSGEDDGEEVYDDEDLSSSDYSVLSILPSISICDSLGYFRLVLQSILIQDPDTKEIFTAIRQSNNKPTMASVTDDWLLYDSNFSMNNLQILTLQDLLDIKRSFPKILFYTMVIVTNSGKQVEEEFKNPNYDNREGISKEQPLDSELSLTNDPQQYFPTAYNNGYNDYIDDEDDEDDGDDASLSEQSGPQMYIPTRMESNVTTAHRSIRTVNSIGEWAFNRHNSVTKIDKSNSNELDNSKTGESTVLSSEPHPMTQLSNSNTTSSNFSHSLKTKNSHKPNSKGNNESNSKNELKKIKSSINAMSAVERSKSLPLPTLLKSLSGIDNPTHATNKDRKRWKFQMNRFKNHKNSGSAGTDKSQRCAIM
Protein: 4,5-DOPA dioxygenase extradiol (MjDOD) (EC 1.13.11.29) (DOPA 4,5-dioxygenase) (B6F0W8)
Organism: Mirabilis jalapa (Garden four-o'clock)
Function: Opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. Produces mainly (S)-betalamic acid. Required for the coloration of flowers.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MKGTYYINHGDPLMYLKKHIKLRQFLEGWQENVVIEKPKSILIISAHWDTNVPTVNFVEHCDTIHDFDDYPDPLYQIQYRAPGAPNLAKKVEELLKESGMECEIDTKRGLDHAAWFPLMFMYPEANIPICELSVQPSKDGIHHYNVGKALSPLLQQGVLIIGSGGTVHPSDDTPHCPNGVAPWAIEFDNWLEDALLSGRYEDVNNFKKLAPNWEISHPGQEHLYPLHVALGAAGKNPKTQLIHRSWAANGVFGYSTYNFTPTTQKTD
Protein: Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1) (P58340)
Organism: Homo sapiens (Human)
Function: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9QWV4}. Nucleus {ECO:0000250|UniProtKB:Q9QWV4}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9QWV4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9QWV4}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9QWV4}.
Interaction partners:
- 14-3-3 protein epsilon
- Centromere protein U
- Nucleophosmin
- DnaJ homolog subfamily B member 6
- Nuclear receptor-binding protein
Sequence:
MFRMLNSSFEDDPFFSESILAHRENMRQMIRSFSEPFGRDLLSISDGRGRAHNRRGHNDGEDSLTHTDVSSFQTMDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQSEVLKYKPGRHNLGNTRMRSVGHENPGSRELKRREKPQQSPAIEHGRRSNVLGDKLHIKGSSVKSNKK
Protein: Schlafen 3 (A0A1L1STQ7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPGASEMKDGPEQEQRHRAGHTWKHGIRASSWLAVGNSQEKSPSVDCRSSHRTLGFSRTGVCLHTAILPTEDNGLNLWKQKGLHLGNRGSDWKTNIIVDQDTDYAELVLFIGEITLGEKNRNSMKDIQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDGMGLDLVNSLPGIMHLPHDYLDFMQHKDYFFVFVKPLKPNQKGPGITTLKTNLYRRINSISDEVKVANAVQLLKSRTDPEEKAESRPSSPGKIVCNETLNECLSLFNRDWLAYEETFCFTKSIHAEVKLTPKEKIFPKEKILELLPQTVSAFANTDGGFLFIGLDGKTQQIIGFEAEKSNLVLLESEIEKCIQQLPVTHFCGEKEKIKYTCKFIEVRKSGAVCAYVCALRVERFCCAVFAAEPESWHVEGGCVKRFTTEEWVKRQMDATAVMPGKVICCPEALYMKPFSQHEGYEHLVRTELGSLLKGTLVISKSWALDLGLQEKQEVIWDVLHISQGSLLTLYVFVQGDENLEGNSSLLGELGAELKGYYKQIALTLKQMLLNHCGYTAEIGIIVKITYLGHKTMCLYDTSTKIRYPQKYYLSAKAVKDLEKALVEILGSYESFYSLPRRNWDSFMSAFLNVGSYIVPVLRNV
Protein: Kinesin-like protein KIN-4C (AtKINESIN-4C) (F4K0J3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Kinesin-like motor protein involved in the control of the oriented deposition of cellulose microfibrils.
Interaction partners:
- Kinetochore protein NUF2 homolog
- Kinesin-like protein KIN-5A
- Increased DNA methylation 1
- Kinesin-like protein KIN-5C
- Kinesin-like protein KIN-5B
- Kinesin-like protein KIN-10A
Sequence:
MESTECVRVAVNIRPLITPELLNGCTDCITVAPKEPQVHIGSHTFTYDFVYGNGGYPCSEIYNHCVAPLVDALFKGYNATVLAYGQTGSGKTYTMGTNYSGDCTNGGVIPNVMEDIFRRVETTKDSSELLIRVSFIEIFKEEVFDLLDSNSSALLKNDSGVQAKHTALSRAPIQIRETASGGITLAGVTEAEVKTKEEMGSFLARGSLSRATGSTNMNSQSSRSHAIFTITLEQKKIAGGSCTTTEDGGEDILCAKLHLVDLAGSERAKRTGADGMRLKEGIHINKGLLALGNVISALGDEKKRKEGGHVPYRDSKLTRLLQDSLGGNSKTVMIACVSPADTNAEETLNTLKYANRARNIQNKAVINRDPATAQMQRMRSQIEQLQTELLFYRGDSGAFDELQILKHKISLLEASNRELHNELQERRVASEHFSKRAYDAQVEKDKLIMIIESVRNGKSLDEIESCQNEDVGLVNKYVSKIQELEGELLHIKNLKKTSNHQYSDDSYDVGPRSNNVLFPSSNESSDCEDKVMDVTDELEFQEKEIEHCSLQEKLDMELKELDKRLEEKEAEMKRFSSGGTSVLKQHYEKKVYDLEQEKRALQREIEGLRHNLASIPSGPGDGAQKLKEEYVQKLNTLETQVSVLKKKQDAQAQLMRQKQKSDDAAIKLQDEIHRIKSQKVQLQQKIKQESEQFRAWKASREKEVMQLKKEGRRNEYEMHKLMALNQKQKLVLQRKTEEASQVTKRLKELLDNRKASSRETLSGANGPGTQALMQAIEHEIEVTVRVHEVRSEYERQTEERARMAKEVARLREENELLKNAKISVHGDTMSPGARNSRIFALENMLATSSSTLVSMASQLSEAEERERVFGGRGRWNQVRTLGDAKSIMNYLFNLASTARCLARDKEADCREKDVLIRDLKEKIVKFSSYVRYMEIQKADLVHQVKAQTSAMKKLSADENLKNEHSMKKQETRNSTIVLEDMDTSDSEASDHEREDPDLDDEWKPEHESERESEQESVIKLNRKRNFKVGRRRSSVVMRRSYEENSETPSDDAVKSDVCCCTCSKSSSCKTMKCQCRATKGSCGPSCGCSSVKCSNRNADGKENNSISESEALENGENSQESDEKDKGQQQQVLASRGAMLLQNALADKPEEETNDDGGTRRRRKPLSDIGNTTGKSNVPRPSQRKKWKKTVLQLVPVGPPALPPTHTNTHLIPEANSVTVDSDTARMPENSDSGESNSIKLKLPRAMRSASSNGSNLLRERNADQNGSESGGNSGFVQSNSGRASGSRTSDEKENHTRRV
Protein: Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) (Q8CBD1)
Organism: Mus musculus (Mouse)
Function: Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development.
Subcellular location: Nucleus {ECO:0000269|PubMed:15879431}.
Interaction partners:
- Estrogen receptor
- Estrogen-related receptor gamma
- Hepatocyte nuclear factor 3-alpha
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Trans-acting T-cell-specific transcription factor GATA-3
- Nuclear receptor ROR-gamma
- Nuclear receptor subfamily 2 group C member 1
- Transducin-like enhancer protein 3
- Histone acetyltransferase p300
- Nuclear receptor corepressor 1
Sequence:
MTHGEELGSDVHQDSIVLTYLEGLLMHQAAGGSGTAINKKSAGHKEEDQNFNLSGSAFPSCQSNGPTVSTQTYQGSGMLHLKKARLLQSSEDWNAAKRKRLSDSIVNLNVKKEALLAGMVDSVPKGKQDSTLLASLLQSFSSRLQTVALSQQIRQSLKEQGYALSHESLKVEKDLRCYGVASSHLKTLLKKSKTKDQKSGPTLPDVTPNLIRDSFVESSHPAVGQSGTKVMSEPLSCAARLQAVASMVEKRASPAASPKPSVACSQLALLLSSEAHLQQYSREHALKTQNAHQVASERLAAMARLQENGQKDVGSSQLSKGVSGHLNGQARALPASKLVANKNNAATFQSPMGVVPSSPKNTSYKNSLERNNLKQAANNSLLLHLLKSQTIPTPMNGHSQNERASSFESSTPTTIDEYSDNNPSFTDDSSGDESSYSNCVPIDLSCKHRIEKPEAERPVSLENLTQSLLNTWDPKIPGVDIKEDQDTSTNSKLNSHQKVTLLQLLLGHKSEETVERNASPQDIHSDGTKFSPQNYTRTSVIESPSTNRTTPVSTPPLYTASQAESPINLSQHSLVIKWNSPPYACSTPASKLTNTAPSHLMDLTKGKESQAEKPAPSEGAQNSATFSASKLLQNLAQCGLQSSGPGEEQRPCKQLLSGNPDKPLGLIDRLNSPLLSNKTNAAEESKAFSSQPAGPEPGLPGCEIENLLERRTVLQLLLGNSSKGKNEKKEKTPARDEAPQEHSERAANEQILMVKIKSEPCDDFQTHNTNLPLNHDAKSAPFLGVTPAIHRSTAALPVSEDFKSEPASPQDFSFSKNGLLSRLLRQNQESYPADEQDKSHRNSELPTLESKNICMVPKKRKLYTEPLENPFKKMKNTAVDTANHHSGPEVLYGSLLHQEELKFSRNELDYKYPAGHSSASDGDHRSWARESKSFNVLKQLLLSENCVRDLSPHRSDSVPDTKKKGHKNNAPGSKPEFGISSLNGLMYSSPQPGSCVTDHRTFSYPGMVKTPLSPPFPEHLGCVGSRPEPGLLNGCSVPGEKGPIKWVIADMDKNEYEKDSPRLTKTNPILYYMLQKGGGNSVTTQETQDKDIWREPASAESLSQVTVKEELLPAAETKASFFNLRSPYNSHMGNNASRPHSTNGEVYGLLGNALTIKKESE
Protein: SPK domain-containing protein (Q9TYX9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MYTNDELTEFMDFLVEQTKDSIYPLVAKKVFKKFPNRRLIPEDKRYPRFCSHFAPKMNEFNKYSIEERIRLMYALRGKVEDDFLTRIQAHGTVELNEKHRISKFISNDGTFSLEDDRERLSIDTTGLEFVRLLDFLIEKTRDVIEPLLVTKRIFQEFSRLEPGPRHKHPDKMYNRKFRYSLAPNMNKYSDYSIEDRVRLFFAFGGEIEDDFLRTIETHGTVQLDDKRRITKYVSNDGNFKLEGIRRHIMSKPATGPEYTRFMEFLIETTKDAVEPMKVPLVLKAFKRQEGRKFTENGYGSRFHKKLAPNMSKWSKYRIEERTRMMFAMKGKVESDFLAQIEASGKVQLDKNQLIVKYTSNDGEIELGGETRLVEKKKRKSTNYHKMHQKRRKIIRSVTDETSLVAKWKRKSDSYYEMYQKRRKIGEKELSDTAEVEEVAPYDEAPNEDQDTQLNPFNAMSNLTTNGPSSNAQEWSNDEPKQEPVFEDIFIQNQHFPSEIEDVPIQEIRRIEPDTKLAYLNIGSSVQGAVITDSGEIKLHKFLNSLELILTSLESDTLDDLLNDIEGIRVRINDEILPPELVITALQTFLLGITRKSRSAASAENKSSHECLRIFKYSLLWLRSPLLWEIQQRVAEEIESHVIGEKIILVADVQQGIRNILFAVSS
Protein: Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) (P27986)
Organism: Homo sapiens (Human)
Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.
Interaction partners:
- Insulin receptor substrate 1
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Platelet-derived growth factor receptor beta
- E3 ubiquitin-protein ligase CBL
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Insulin receptor substrate 2
- Epidermal growth factor receptor
Sequence:
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVHVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
Protein: Methoxy mycolic acid synthase MmaA3 (EC 2.1.1.-) (Mycolic acid methyltransferase) (MA-MT) (S-adenosylmethionine-dependent methyltransferase) (AdoMet-MT) (SAM-MT) (A5U028)
Organism: Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Function: Involved in the biosynthesis of methoxymycolic acid. It catalyzes the O-methylation of the hydroxy group of the hydroxymycolate to form a methyl ether.
Interaction partners:
Sequence:
MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFERDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGLTLSKNQHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQPHFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDCNQFTLAK
Protein: Glutamate receptor (Q71E59)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
Interaction partners:
Sequence:
MRILVLIPLLWGLGEGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLVTPSFPAEGETQFVLQLRPSIRGALLSLLDHYDWSRFVFLYDTDRGYAVLQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQEKKFVIDLEAERLQNILEQIVSVGKHVKGYHYIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIKLMQRWNKLDQREYPGSESPPRYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPAAPWNQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELSMGNDSAMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQFEGYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLAITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKKLKLTFSEAMRNKARLSITGSLGENGRVLTPDCPKAVHSGPSYRHGPALAVVSSDLP
Protein: Negative elongation factor complex member A (H7C0W2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XLCFHGLSSAVKLKLLLGTLHLPRRTVDETPAVRSALCPFYSFLHAVLRHSNKWMKGALMEIIQLASLDSDPWVLMVADILKSFPDTGSLNLELEEQNPNVQDILGELREKVGECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKPKSATLRAELLQKSTETAQQLKRSAGVPFHAKGRG
Protein: Venom peptide 3 (OdVP3) (VP3) (C7DT09)
Organism: Orancistrocerus drewseni (Solitary wasp)
Function: Exhibits strong antimicrobial activity against the fungi C.albicans and B.cinerea, and weaker activity against the Gram-negative bacterium E.coli and the Gram-positive bacterium S.aureus.
Subcellular location: Secreted {ECO:0000269|PubMed:19857508}. Target cell membrane {ECO:0000305}. Note=Has an amphipathic alpha-helical conformation. {ECO:0000305|PubMed:21184791}.
Interaction partners:
Sequence:
MTKQSIVIVLFAAIAMMACLQRVTAEPAPEPIAAPIAEPYANPEAIASPEAKDLHTVVSAILQALGKK
Protein: Receptor-type guanylate cyclase gcy-7 (EC 4.6.1.2) (H2L002)
Organism: Caenorhabditis elegans
Function: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses toward salt ions in ASEL (ASE left) sensory neurons.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Cyclic nucleotide-binding domain-containing protein
- Cyclic nucleotide-gated channel
Sequence:
MKPFYSMSLVLFLVITLLPKPMFPQVATGTTGNVIRVGFIHCRDFQSAPITVGYRTSAAAASIAVDRLKRENLMSGWEFNFTIEFDDCVESEAAGMTVDLIEKHNVDVIIGPTMNQPTLAAFIVSNYFNRPIIAWGLVNAAQLDDFERFPNAGILSAGQRSLGVAIRAVLKRYEWSQFVYAYFTEEDTEKCVTMRNDLQQVVSYFGDIILAYSIQVADISNDGMIEALKKIQSRGRIIVTCMKDGIGLRRKWLLAAEEAGMIGDEYVYVFSDIKSKGYVVPLLGGGERPSWILSTGSDENDTRALKAFKQSIFICDMMGQGSIATNYTIFGQEIIARMKEAPYFCTKDCEGENFTVAATYAGQLHDAVYAYGVALDKMLKAGQIAQYRNATAFMRYFPQSFIGMSGNVTINEKGTRNPTLFLLALDENNNNTRMATIYVENMSATFNALYSDEGVMWASRKNNARPVDVPLCGFTGNLCPKSFVDEYLIWVIVAIVVLFLAITAAACGIYFSIQARRQEIERLNRLWQIPFIHLHQINSKQKGKGEHSVRSLQSGTSTLSSRTTVSFKTESRNFLFFSLQRESDYEPVVAKKHAYRPRLDDDKCTFMRSLRNLDQDNLNRFIGLCLDGPQMLSVWRFCSRGSIADVILKATIQMDNFFIYSLIKDMVHGLVFLHGSMVGYHGMLTSKCCLIDDRWQVKISNYGLQDLRSPEMYEKKDLLWSAPELLRAEDIKGSKEGDVYSLGIICAELITRKGVFNMEDRKEDPEEIIYLLKKGGLKSPRPDLEYDHTIEINPALLHLVRDCFTERPSERPSIETVRSQLRGMNSSRNDNLMDHVFNMLESYASSLEEEVSERTKELVEEKKKSDVLLYRMLPKTVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLASKCTPLQVVNLLNDLYTIFDGIIEKHDVYKVETIGDGYLCVSGLPHRNGNEHVRQIALMSLAFLSSLQFFRVPHLPSERINLRIGMNCGSVVAGVVGLTMPRFCLFGDAVNTASRMESNGKPGKIHVSAEANRMLHLVGGFDTESRGEVIIKGKGVMETFWLTGQGTGAVSGARHVSAKKVSKKMDEIHRQETLKSDEQLSD
Protein: cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) (I1HY48)
Organism: Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Interaction partners:
- Aldehyde dehydrogenase 1
- Aldehyde dehydrogenase 1
- Aldehyde dehydrogenase 1
- Ferulate-5-hydroxylase
- Peroxidase
- Peroxidase
- Peroxidase
- MADS-box domain-containing protein
Sequence:
MGSIASEERTVTGWAARDADGHLSPYTYTLRKTGPEDVLVKVLYCGICHTDIHQAKNHLGASKYPMVPGHEVVGEVVEVGGEVSKYSAGDVVGVGVIVGCCRECRPCKASVEQYCNKRIWSYNDVYTDGRPTQGGFSSAMVVDQKFVVRIPAGLAPEQAAPLLCAGVTVYSPLKHFGLMSPGLRGGILGLGGVGHMGVKVAKSMGHHVTVISSSGKKRAEAMDDLGADAYLVSSDADQMAAAADSLDYVIDTVPVKHPLEPYLSLLKMDGKLVLMGVIGEPLSFVSPMVMLGRKSITGSFIGSMEETEEVLKFCVEKGLTSQIEVVKMDYLNEALERLERNDVRYRFVVDVAGSKIEDAA
Protein: Moderate conductance mechanosensitive channel YbiO (P75783)
Organism: Escherichia coli (strain K12)
Function: Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:22874652}; Multi-pass membrane protein {ECO:0000269|PubMed:22874652}.
Interaction partners:
- Low conductance mechanosensitive channel YnaI
- Mechanosensing system component YbdG
- Miniconductance mechanosensitive channel MscM
- Large-conductance mechanosensitive channel
- Small-conductance mechanosensitive channel
Sequence:
MRWILFILFCLLGAPAHAVSIPGVTTTTTTDSTTEPAPEPDIEQKKAAYGALADVLDNDTSRKELIDQLRTVAATPPAEPVPKIVPPTLVEEQTVLQKVTEVSRHYGEALSARFGQLYRNITGSPHKPFNPQTFSNALTHFSMLAVLVFGFYWLIRLCALPLYRKMGQWARQKNRERSNWLQLPAMIIGAFIIDLLLLALTLFVGQVLSDNLNAGSRTIAFQQSLFLNAFALIEFFKAVLRLIFCPNVAELRPFTIQDESARYWSRRLSWLSSLIGYGLIVAVPIISNQVNVQIGALANVIIMLCMTVWALYLIFRNKKEITQHLLNFAEHSLAFFSLFIRAFALVWHWLASAYFIVLFFFSLFDPGNSLKFMMGATVRSLAIIGIAAFVSGMFSRWLAKTITLSPHTQRNYPELQKRLNGWLSAALKTARILTVCVAVMLLLSAWGLFDFWNWLQNGAGQKTVDILIRIALILFFSAVGWTVLASLIENRLASDIHGRPLPSARTRTLLTLFRNALAVIISTITIMIVLSEIGVNIAPLLAGAGALGLAISFGSQTLVKDIITGVFIQFENGMNTGDLVTIGPLTGTVERMSIRSVGVRQDTGAYHIIPWSSITTFANFVRGIGSVVANYDVDRHEDADKANQALKDAVAELMENEEIRGLIIGEPNFAGIVGLSNTAFTLRVSFTTLPLKQWTVRFALDSQVKKHFDLAGVRAPVQTYQVLPAPGATPAEPLPPGEPTL
Protein: DNA replication licensing factor mcm5 (EC 3.6.4.12) (Cell division control protein nda4) (Minichromosome maintenance protein 5) (P41389)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Role in DNA replication and essential for viability.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cell division cycle protein cdt1
- DNA replication complex GINS protein psf2
- DNA replication complex GINS protein sld5
- DNA replication licensing factor mcm6
- Origin recognition complex subunit 5
- DNA replication licensing factor mcm2
- DNA replication complex GINS protein psf3
- DNA replication licensing factor mcm3
- Cell division control protein 45 homolog
- DNA replication licensing factor mcm7
Sequence:
MAAATGWERSAVYYTPVLPGEQELDSNVSHEKNFIQFIEEFVIDNDFIYRTQLRDNLVVKQYMLNIDLRHLISYNEDLAHLLLSQPTDILPLFESAVTTVAKRLLYRSQENASTNIPTCQVTLRYDANILPIRNLTASHISKLVRVPGIIIGASTLSCRATALHLVCRNCRATRILQISGGFSGVQLPRVCEAPVLDGEKKDCPMDPFIIDHSKSTFIDQQVLKLQEAPDMVPVGELPRHILLNADRYLTNQITPGTRCVITGIFSIFQNKSVKASGAVAIRNPYIRVVGIQMDSNDGSKSTPLFSEEEEEEFLEISRTPNLYDIISNSISPAIYGNVDIKKAIACLLFSGSKKILPDGMRLRGDINVLLLGDPGTAKSQFLKFVERLAPIAVYTSGKGSSAAGLTASIQRDSVTREFYLEGGAMVLADGGIVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTILNSRTSVLAAANPIFGRYDDMKTPGENIDFQSTILSRFDMIFIVKDEHDETKDRNIARHVINLHTNLQESSETLAIGEIPFDKFRRYINYCRHKCAPNLDAEAAEKLSSQFVAIRKRVHQSEQDSNSRSTIPITVRQLEAIIRITESLAKMSLSPIASEAHATEAIRLFLTSTLAAATQSSPEVTEEVKKIEASLRKRLPIGFQASYRMLIREYVNGHGYSQHALEMALQILSSKETIQLRNGGQTVYRSGV