wanglab/gogpt-training-data huggingface dataset:
Protein: tRNA 2-selenouridine synthase (EC 2.9.1.3) (Selenophosphate-dependent tRNA 2-selenouridine synthase) (P33667)
Organism: Escherichia coli (strain K12)
Function: Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
Interaction partners:
- Selenide, water dikinase
- Protein nucleotidyltransferase SelO
- Selenocysteine-specific elongation factor
- L-seryl-tRNA
- tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC
- Uncharacterized protein YqeB
- Uncharacterized protein YqeC
- tRNA-specific 2-thiouridylase MnmA
Sequence:
MQERHTEQDYRALLIADTPIIDVRAPIEFEHGAMPAAINLPLMNNDERAAVGTCYKQQGSDAALALGHKLVAGEIRQQRMDAWRAACLQNPQGILCCARGGQRSHIVQSWLHAAGIDYPLVEGGYKALRQTAIQATIELAQKPIVLIGGCTGSGKTLLVQQQPNGVDLEGLARHRGSAFGRTLQPQLSQASFENLLAAEMLKTDARQNLRLWVLEDESRMIGSNHLPECLRERMTQAAIAVVEDPFEIRLERLNEEYFLRMHHDFTHAYGDEQGWQEYCEYLHHGLSAIKRRLGLQRYNELAARLDAALTTQLTTGSTDGHLAWLVPLLEEYYDPMYRYQLEKKAEKVVFRGEWAEVAEWVKAR
Protein: Diacylglycerol O-acyltransferase 2-like protein 6 (EC 2.3.1.-) (Diacylglycerol O-acyltransferase candidate 3) (hDC3) (Q6ZPD8)
Organism: Homo sapiens (Human)
Function: Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters. Able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG).
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAFFSRLNLQEGLQTFFVLQWIPVYIFLGAIPILLIPYFLLFSKFWPLAVLSLAWLTYDWNTHSQGGRRSAWVRNWTLWKYFRNYFPVKLVKTHDLSPKHNYIIANHPHGILSFGVFINFATEATGIARIFPSITPFVGTLERIFWIPIVREYVMSMGVCPVSSSALKYLLTQKGSGNAVVIVVGGAAEALLCRPGASTLFLKQRKGFVKMALQTGAYLVPSYSFGENEVFNQETFPEGTWLRLFQKTFQDTFKKILGLNFCTFHGRGFTRGSWGFLPFNRPITTVVGEPLPIPRIKRPNQKTVDKYHALYISALRKLFDQHKVEYGLPETQELTIT
Protein: ATP-dependent RNA helicase (EC 3.6.4.13) (F5H5U2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEHVTEGSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKYKRNKIFMEFRKLQSAFVHRCGRTARIGHGGSALVFLLPMEESYINFLAINQKCPLQEMKPQRNTADLLPKLKSMALADRAVFEKGMKAFVSYVQAYAKHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVNTDTIPFKDKIREKQRQKLLEQQRREKTENEGRRKFIKNKAWSKQKAKKEKKKKMNEKRKREEGSDIEDEDMEELLNDTRLLKKLKKGKITEEEFEKGLLTTGKRTIKTVDLGISDLEDDC
Protein: Sec-independent protein translocase protein TATB, chloroplastic (Protein HIGH CHLOROPHYLL FLUORESCENCE 106) (Protein TWIN-ARGININE TRANSLOCATION B) (Q94G16)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000305|PubMed:14653819, ECO:0000305|PubMed:19854178}; Single-pass membrane protein {ECO:0000305|PubMed:14653819, ECO:0000305|PubMed:19854178}. Note=The C-terminus is located in the stroma. {ECO:0000250}.
Interaction partners:
Sequence:
MTPSLAIASSTSTMLLCPKLGTCSMSLSTCTPTSHSKIHHFHLYSLGKRLFTPWNGFKQLGFSTKPKKPLFHFIGKKGRCKGKVVYASLFGVGAPEALVIGVVALLVFGPKGLAEVARNLGKTLREFQPTIREIQDVSREFKSTLEREIGIDDITNPLQSTYSSNVRNTTPTPSATEITNNSQTAVDPNGKVDESKAYSSEEYLKITEEQLKAVAAQQQEQTSSPKEDEIEQQIQPPANETAATVPPPQKPESESSLPSDL
Protein: Probable WRKY transcription factor 56 (WRKY DNA-binding protein 56) (Q8VWQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MEGVDNTNPMLTLEEGENNNPFSSLDDKTLMMMAPSLIFSGDVGPSSSSCTPAGYHLSAQLENFRGGGGEMGGLVSNNSNNSDHNKNCNKGKGKRTLAMQRIAFHTRSDDDVLDDGYRWRKYGQKSVKNNAHPRSYYRCTYHTCNVKKQVQRLAKDPNVVVTTYEGVHNHPCEKLMETLSPLLRQLQFLSRVSDL
Protein: Eukaryotic translation release factor 3, isoform C (M9PD08)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSKGAGSRYIYSFSQWRKKTDPADSWDVDDAVITPEDEEVEDAEFTEGEATPKVSKKKVVKVEENRSKREHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWYLSWALDTNQEERDKGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQTREHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGLSGYGLKDQIPETLCPWYRGPAFIPFIDELPSLNRKSDGPFIMPIVDKYKDMGTVVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSPGFVLCDAANPIKTGKIFDAQVVILEHKSIICAGYSAVMHIHCAAEEVTVKALICLVDKKSGDKSKTRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVVE
Protein: Regenerating islet-derived protein 3-gamma (REG-3-gamma) (Pancreatitis-associated protein 1B) (PAP-1B) (Pancreatitis-associated protein IB) (PAP IB) (Regenerating islet-derived protein III-gamma) (REG III) (Reg III-gamma) [Cleaved into: Regenerating islet-derived protein 3-gamma 16.5 kDa form; Regenerating islet-derived protein 3-gamma 15 kDa form] (Q6UW15)
Organism: Homo sapiens (Human)
Function: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P42854}. Cytoplasm {ECO:0000250|UniProtKB:P42854}.
Interaction partners:
- Regenerating islet-derived protein 3-alpha
- Interleukin-22
- Interleukin-22 receptor subunit alpha-2
Sequence:
MLPPMALPSVSWMLLSCLILLCQVQGEETQKELPSPRISCPKGSKAYGSPCYALFLSPKSWMDADLACQKRPSGKLVSVLSGAEGSFVSSLVRSISNSYSYIWIGLHDPTQGSEPDGDGWEWSSTDVMNYFAWEKNPSTILNPGHCGSLSRSTGFLKWKDYNCDAKLPYVCKFKD
Protein: SMAD family member 3 (H0YKE2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAEC
Protein: At2g43770 (Putative splicing factor) (Transducin/WD40 repeat-like superfamily protein) (O22826)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein STABILIZED1
- Small nuclear ribonucleoprotein Sm D2
- Pre-mRNA-processing factor 19 homolog 2
- Transducin/WD40 repeat-like superfamily protein
- Pre-mRNA-splicing factor SPF27 homolog
- 110 kDa U5 small nuclear ribonucleoprotein component CLO
- 109 kDa U5 small nuclear ribonucleoprotein component GFL
- Pre-mRNA-processing-splicing factor 8B
- Pre-mRNA-processing-splicing factor 8A
- Small nuclear ribonucleoprotein E
Sequence:
MEIMSRENETALSGPRPMEWSTVPHSASQGPGPNGKNRTSSLEAPIMLLSGHPSAVYTMKFNPAGTLIASGSHDREIFLWRVHGDCKNFMVLKGHKNAILDLHWTSDGSQIVSASPDKTVRAWDVETGKQIKKMAEHSSFVNSCCPTRRGPPLIISGSDDGTAKLWDMRQRGAIQTFPDKYQITAVSFSDAADKIFTGGVDNDVKVWDLRKGEATMTLEGHQDTITGMSLSPDGSYLLTNGMDNKLCVWDMRPYAPQNRCVKIFEGHQHNFEKNLLKCSWSPDGTKVTAGSSDRMVHIWDTTSRRTIYKLPGHTGSVNECVFHPTEPIIGSCSSDKNIYLGEI
Protein: Maternally expressed PAB C-terminal protein (Poly(A)-binding protein-like) (Q9LT82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Encodes almost entirely the C-terminal domain of poly(A)-binding proteins (PABPs). Plays a role in normal seed development and growth.
Interaction partners:
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
- Homeodomain-like superfamily protein
- Formin-like protein 5
- Homeobox-leucine zipper protein HDG6
- Histone-lysine N-methyltransferase MEDEA
- MADS-box transcription factor PHERES 1
- Transcriptional activator DEMETER
- Homeobox-leucine zipper protein HDG9
- Homeobox-leucine zipper protein HDG8
- Nudix hydrolase
Sequence:
MNRLCFFNKVVKVARGDSPPFDLASLPPKEQRDLIGETLFFMVEELEPQFAPKITGMILELDQDKVLHLLVTPKAFKEMVKEAMEVLAHSFLQQMKIARGKRC
Protein: Homeobox C4 (Q86TF7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPSYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (Q57VN8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361146}.
Interaction partners:
- Kinesin, putative
Sequence:
MISPKDTSNYGTLAGRGRERQAFLSTGLTRSDGSVAVEVELEDRIGIGIKGELHTLFSCVGDAKPLYEELGGVEGIAERLGTSITDGIDSFSVENRRAVYGRNELPEEAPLTFWKIFKAAWSDRMIILLTLAACVSLILGLTVPEPGHEKVDYKTGWIEGTAILMAVIAVTSASSIQDYRKELKFRALVEENSAQPISVIRDGHKVTVDVTEIVVGDLVSLSPGLVIPVDGLYVRGLSVVVDESSVTGENDLKKKGAEHPILLSGTVVSTAEDAYILACAVGESSFGGKLLMESRLDGEPRATPLQERLDELAGFIGRIGIGAAVILMSLLSLFYILLVLRGKEELRAKKFLDIFLLCVTIVVVAVPEGLPLAVTIALAYSQSQMQKDNNQVRRLCACETMGNATQICSDKTGTLTQNRMTVVQGYIGMRRFRVSNPGDPSSTVNLEGVSSDAQSLLMLGLALNSSSEKELLPGNVGAESDLLSRWTWRTDKGNKTDQAILDFVDRVLISVPGSCNDKELPHQKLRMTNRSRGFAIFPFTSERKFMTAVVAGADGVVMQYVKGGSDRVLGMCNRYLSSEGREEPLTEEVTEMITAQIRSIAGDANRTIGVAYGRIGTDGAVPEEEPEGPFVWLALLGIQDPLRPEVVDAVRMCQRAGVTVRMCTGDNLDTAVAISRQCGIYNRLRGDLALTGKDFRNLVYDTYGDEANMEKFWPVLDRMMVMGRSQPLDKQLLVLMLMLRGEVVAVTGDGTNDAPALRLANVGFVMRSGTDIAVKSGDIVLLDDNFRSVQRAVVWGRTVNDNIRKFLQLQLSINIASIVVVFVGSFLSAHDMSPLTTVQLLWVNLLMDTLAALALATEQPTEDCLNRGPSSPRAPLVSRRMWLTILTATVVQVVSVLLLTQYGGKWLKAKGKELPTVVFNVFIFFTIFNMFNARKVYDEVNVFEGLFIRSKSFLVIVVCCVGFQVLAVEVLKEFMSCVPLRAEQWIASILIASLTLVFVSVSRLIPVSEPSFEKGAELEDMEPGARRIAVKLAEDVEHHSSASNNVGSYMRFGQRLVARAQWQRVREHVTMRGVSQFWWSRHSHPRERGWRRMSAWCEERIR
Protein: Pumilio domain-containing protein C4G8.03c (Q09829)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Pumilio homology domain family member 6
- Poly
- Putative NADPH dehydrogenase C23G7.10c
Sequence:
MVNRDAYNELNLNKKSQETNRKPSPLSSYTSISRELDYANQSPFSSNSFSPTELKARTSATFDVRSASTSPINASDFHKYSHDPFQRLFKAKGNASFSKTKSFPSSVTYSPSEETFPLTSGMNKSVHEYPFTLSESAISSSHKSSIPERRNFDSSVSVSNPLLHWNNVDTLLRDGSLENVNNSRQDQFLPYKTFSSTISNSDFLHRESSFSSLIDEESKLASLRNLNINDRPPLPVLKNSERNLLHRQLLSNHPFFSQNNVSLSTNSKNYSTDFTKIQSDSSLLQNRQQNHRIETDQLSHFPDHLDPSRIPSPYQPSSLQPLESRKLHSKVDVHSKKLNALSQLNPILRSENVLQNDNHHSSLSMDNDPTNVSTKNRNNQTVGEHPYVDDNKKKKKGPAKPKEKATLGKTVNSFFGSHSTSNYSKVPLSAKLTGEKSDDLSNLLKNKGKKKSQDNQIPHLVGFLGHLSTICKDQYGCRYLQKLLDENPKVNASLFFPEIRQSVVQLMIDPFGNYMCQKLFVYASREQKLSMLNGIGEGIVDICSNLYGTRSMQNIIDKLTSNEQISLLLKIIIPSLTTLACDNNGTHVLQKCIAKFPPEKLEPLFLSMEENLITLATNRHGCCILQRCLDRTNGDIQERLVNSIIKSCLLLVQNAYGNYLVQHVLELNIQPYTERIIEKFFGNICKLSLQKFSSNAIEQCIRTASPSTREQMLQEFLSFPNIEQLLDDCYANYVMQRFLNVADESQKFLILRSISHVIPKIQNTRHGRHILAKLTSSTSS
Protein: Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) (Q6ZN18)
Organism: Homo sapiens (Human)
Function: Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:29499137}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:29499137}.
Interaction partners:
- Histone-binding protein RBBP7
- Histone-binding protein RBBP4
- Polycomb protein EED
- Polycomb protein SUZ12
- Histone-lysine N-methyltransferase EZH2
- Protein Jumonji
- Histone-lysine N-methyltransferase EZH1
- PHD finger protein 1
- Metal-response element-binding transcription factor 2
- Polyhomeotic-like protein 1
Sequence:
MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ
Protein: protein-serine/threonine phosphatase (EC 3.1.3.16) (O49973)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
MAVPPLLLVAVAVAALSILVLVVFAFRRCRRRRQRHPLQAAAVAPTPVAVQDEDIDRPLLSENQSDHSRQNISFLGSSVGEPSKIQTNRSNTSPRSHAIADTGRIYPAECCVTQGETHVINVENDTSEEFQLGSTLRRTPPPKWPTPDQKHRRRVSGDDNHNGSVPLKDNTYHSRLDLEVIAGPSHGISCSRQSSRPSMLPITLGRVPPSDLVLKDSEVSGKHAQINWNGKTLKWELVDMGSLNGTFLNSQAVHHPSAGSRHWGEPAELAHGDIITLGTSSKLSVQILLQNQRVPAGVGMASDPMVARRSGKKLPMEDISFCQCPLQGVEHFGLFGIFDGHGGDGAAKAVSKILPEHLGYILSHPETKERVQSYSDASDVLRYAFTLTEDTIDHQYEGCTGTALLIWFDQNKDCFAQCANLGDSACVMSVNGKTIDMTEDHRVTSATERARIARTGQPLRDGEARLSGLNLARMFGDKFLKEQDPRFSSEPYVSQAVRITKACTAFAVIASDGLWDVISTKRAVQLVVEGKERRSSGDATSAAARVASRVLDEARSLRTKDNTSVIFVDFDVLRRDPCISPVD
Protein: Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) (Q9H3N1)
Organism: Homo sapiens (Human)
Function: May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11152479, ECO:0000269|PubMed:22045338, ECO:0000269|PubMed:27502484, ECO:0000269|PubMed:31304984, ECO:0000269|PubMed:37648867}; Single-pass type I membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:22045338, ECO:0000269|PubMed:27502484, ECO:0000269|PubMed:31304984}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000305|PubMed:30425049}. Note=Predominantly found in the endoplasmic reticulum (PubMed:11152479). Secreted in the extracellular space following thrombin stimulation (PubMed:30425049). Localizes to mitochondria-associated endoplasmic reticulum membrane (MAM); palmitoylation is required for MAM localization (PubMed:22045338, PubMed:27502484, PubMed:31304984). {ECO:0000269|PubMed:11152479, ECO:0000269|PubMed:22045338, ECO:0000269|PubMed:27502484, ECO:0000269|PubMed:30425049, ECO:0000269|PubMed:31304984}.
Interaction partners:
- Calnexin
- Thioredoxin
- Thioredoxin-related transmembrane protein 2
Sequence:
MAPSGSLAVPLAVLVLLLWGAPWTHGRRSNVRVITDENWRELLEGDWMIEFYAPWCPACQNLQPEWESFAEWGEDLEVNIAKVDVTEQPGLSGRFIITALPTIYHCKDGEFRRYQGPRTKKDFINFISDKEWKSIEPVSSWFGPGSVLMSSMSALFQLSMWIRTCHNYFIEDLGLPVWGSYTVFALATLFSGLLLGLCMIFVADCLCPSKRRRPQPYPYPSKKLLSESAQPLKKVEEEQEADEEDVSEEEAESKEGTNKDFPQNAIRQRSLGPSLATDKS
Protein: EF-hand domain-containing protein (Q57WB3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSATEAVVEPKAPDVCTEANERPPTESGVAAPVKRLFDLLQEDSKERVVRLLTAFRELTLLEQESLAQEMGVTLPKEEKWRAPCPLIARQPSGPSLEVRRRDPSYVALCPSVSSALRELGSKEAARRLPDADLRKLVEGALGEDGVYLTVPESDGEGCAAASERVGVVDDGKPPLLVRSRCYQALRLARDEEIETDAQYTRPRVLNVTGIPLEESDVWEWFNLLDVARNGTVGVDAFLTSVRELDRGFGTSSKVQEAFEDESRSLSVDGQLSFDKFAYLVTRFSRY
Protein: Large ribosomal subunit protein bL9m (39S ribosomal protein L9, mitochondrial) (Q5SZR1)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MAAPVVTAPGRALLRAGAGRLLRGGVQELLRPRHEGNAPDLACNFSLSQNRGTVIVERWWKVPLAGEGRKPRLHRRHRVYKLVEDTKHRPKENLELILTQSVENVGVRGDLVSVKKSLGRNRLLPQGLAVYASPENKKLFEEEKLLRQEGKLEKIQTKAGEALGVVVAPHTLKLPEEPITRWGEYWCEVTVNGLDTVRVPMSVVNFEKPKTKRYKYWLAQQAAKAMAPTSPQI
Protein: Forkhead box C1-B (Q9DE24)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine-induced endothelial cell migration. Plays a role in epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q61572}.
Interaction partners:
Sequence:
MQARYPVSSQSPLGVVPYIPGDQGFYRTATGGGYTGMPAPMSMYSHATHEQYPGGMARAYGPYAPAQQPKDMVKPPYSYIALITMAIQNSSDKKITLNGIYQFIMERFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVLREKEDRDRQGKDNPGQACEQDAQQPVKLRDIKTENGACTPPHDSTPPLSTVPKTESPDRSGGSACSGSPQSQTPQQAFSMDTIMTGLRGSPQHAAELPASRAALPGSVSLTYSPTPQPAHYSPPCGQPATYHCNMQATSLYTGDRGHGDDTLPEYTNTTNASSISHPHQSSSQESQHLQQNRLAPWYLNQSGELGHLSASYPGQQQNFHAVREMFETQRIALNSSPVTGSNSCQMAFPSSQPLYRASGAFVYDCSKF
Protein: Sphingosine kinase 2 (EC 2.7.1.91) (F2Y4A3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the production of sphingolipid metabolites. Phosphorylates sphingosine and various l sphingoid long-chain base (LCB) products, such as phytosphingosine (PHS, 4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-erythro-dihydrosphingosine, but has a very few activity toward D,L-threo- dihydrosphingosine. Is required for abscisic acid (ABA) signaling that mediates stomatal closure, inhibition of seed germination and root elongation. May function upstream of PLDALPHA1 and phosphatidic acid (PA) in an amplification response to ABA that mediates stomatal closure.
Subcellular location: Vacuole membrane {ECO:0000305|PubMed:21330371}; Peripheral membrane protein {ECO:0000305|PubMed:21330371}. Note=Associated with the tonoplast.
Interaction partners:
- Alkaline ceramidase
- Sphingosine-1-phosphate lyase
- Neutral ceramidase 1
- 3-dehydrosphinganine reductase TSC10B
- 3-dehydrosphinganine reductase TSC10A
- Sphinganine C4-monooxygenase 2
- Sphinganine C4-monooxygenase 1
- Neutral ceramidase 3
- Neutral ceramidase 2
- Sphingolipid delta
Sequence:
MENDQFMCPTDIITGIVFIDGELAMLTLTADGELRWTEYGLRQYLSMKKDVLGFIVEGKQIRVKAVVEKEAGGICCGQFGGDFVRKDFVFEPLIDQNGWCYKLRQYLDSLGRPKRLLVFVNPFGGKKSAREIFVKEVKPLFEDADVQLEIQETKYQLHAKEFVKSMDVSKYDGIVCVSGDGILVEVVNGLLERADWRNALKLPIGMVPAGTGNGMIKSLLDTVGLRCCANSATISIIRGHKRSVDVATIAQGNTKFFSVLMLAWGLIADIDIESEKFRWMGSARIDFYALQRIICLRRYNGRILFLPAPGFEGYGQPASCSLYQEPHVSDKEVGYQGPETKFEDLEWREMKGPFVTIWLHNVPWGSENTLTAPAAKFSDGYLDLIVLKNCPKLVLLSLMRQTSSGTHVESPYIVYIKVKAFVLEPGALVDEPDKEGIIDSDGEVLARGKRTYKCDQKALMSYDKLQVTVDQGLATLFSPEY
Protein: Galactose-binding protein (Q2TS30)
Organism: Carcinoscorpius rotundicauda (Mangrove horseshoe crab) (Limulus rotundicauda)
Interaction partners:
Sequence:
MKNIMYFSLVMLLLTFLVVSPTLAEWTHINGKLSHLTVTPRFVWGVNNVHDIFRCTRPCTGSNWIKVEGSLKQIDADDHEVWGVNSNDNIYKRPVDGTGSWTQIKGGLKHVSASGYGYIWGVSSKDQIFKCPKPCNGEWELVDGSLKQVDGGRDLVYGVNQNDEIYRRPVDGSGVWENIPGKLKHISGSGSWEVFGVNCNDQIFRCKKPCSGQWVRLPGHLKQCDASGDSLMGVNSNDDIFESVPASKSCWLNPFL
Protein: Protein prickle (Protein spiny legs) (A1Z6W3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12015986, ECO:0000269|PubMed:12642492, ECO:0000269|PubMed:12941693, ECO:0000269|PubMed:15937478}; Peripheral membrane protein {ECO:0000269|PubMed:12015986, ECO:0000269|PubMed:12642492, ECO:0000269|PubMed:12941693, ECO:0000269|PubMed:15937478}; Cytoplasmic side {ECO:0000269|PubMed:12015986, ECO:0000269|PubMed:12642492, ECO:0000269|PubMed:12941693, ECO:0000269|PubMed:15937478}. Note=Localized to the proximal wing cell boundary where fz and dsh localization is antagonized by binding the dsh DEP domain and preventing dsh cortical localization. Localization to the anterior photoreceptor cell membrane. {ECO:0000269|PubMed:12015986, ECO:0000269|PubMed:12642492, ECO:0000269|PubMed:12941693, ECO:0000269|PubMed:15937478}.
Interaction partners:
- Diego, isoform A
- Segment polarity protein dishevelled
- Vang-like protein
- Frizzled
- Frizzled-3
- Protocadherin-like wing polarity protein stan
- Dishevelled associated activator of morphogenesis, isoform D
- Protein espinas
- Rho-associated protein kinase
- Protein inturned
Sequence:
MSSLSTGGGAGGSSGGPGGADAAAAPAAGQATVTATGNMEPAMVPRTANLLACKQWWRVCFLYGDQQKYYRQLYSKAAAQRLADANQEPDNARDREYDTVDCDLIAGQLDAVEDADDGIDLGDHSSTPKGGATTAGRPLFPHSSSPRRSKKLLRSLRAHVRGEKLPKNDTTTANESSEVTQRNARVTVLDDPFLFGIDADHLGDLVVRGKRYSTLDATENMARFYAEQEATAQVLEIIEQEEESPEQEAPKPALPPKQKQQRPVPPLPPPPANRVTQDQGTQPAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEVATGAAQQESNEPISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSGGMGLPSSSSASALYAAQAAAGILPTSPLPLQRHQQYLPPHHQQHPGAGMGPGPGSGAAAGPPLGPQYSPGCSANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHPAGGTSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRPHPQAPLPARIPSSHASSSPPMSPQQQQQHQATFNQAMYQMQSQQMEAAGGLVDQSKSYAASDSDAGVVKDLEHGGHMGGGDLTDFSGGRASSTSQNLSPLNSPGDFQPHFLPKPMELQRDGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLLENPHTASMPELAGKLVAPPAHMQHLSQLHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPPELMGSPTHSAGDRSLNTPMSTQSASHAPPHPVSILSGASSSSPMSGEPAKKKGVRFEGIPDTLPRSRSYSGNGAGTSGGGERERDRDKDKEGGGRHGHGHSSRRRRRRKSSSSSSHHRSGSGHRSHSTTRADTYAPAQPLSSSYQGPPSVLQAANLVHESPSRQQREREREREREESEESDVCSTCSSSSSSSEDYMMMYQLPQRRHYGGVRVSYVPNDALAYDRKRKPSELGGDKDKNCIIS
Protein: Nicotinic acetylcholine receptor alpha4, isoform G (M9PDC9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MVHGAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRIPIIEQKDLDFSGTSAGRCRPPQ