wanglab/gogpt-training-data huggingface dataset:
Protein: Erythrocyte vesicle protein 1 (Q9U0I6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Rhoptry protein RHOP148
Sequence:
MYKKCFILYPIFFPSLYIYIIKNDHLNSEQSSFSRIIAEYCDTKKNEFFLGESILGATSSRSTSLNIEQNKNTNIIKDKNEQSYDEHIVMNPNTNRALSINTVFNYNKENKEKKIFSFSEFPKEFNILDVVWPYMKQPKELFKKSSVITFLMDHYFRHELYILESRIAMKPRRRTYEAPCFEHDDFELERDFFFLEDCDEDHQFFNKYKSYFFSLNVLDHCKSLRTKKQKCNNMKDDEVSNINDDEVSNINDDEVSNINDDEVSNIKDDVVRNINDDVVRNINDDEVHHTNDDKVNHTNDDKVNHTNDDKVNHTNDDKVNHTNDDKVNHTNDDNVNHTNDDKVNHTNDDKVNHTNDDKVNHTNDDKVNHTNNYYNDKKNNAGDIKTNNSIREEKKLEHPDRNIEKKIDLITYNKKRIEEYYDSIISYFFGLIILYHNKKETNLNYYTKFLTLDKYKNMYNCLNNDISKIYEKAILFSHEEFCIIQKKDLKPHGLRGNIKYYYFFNRIVSTSLYLLHEILQKLDGKMYTFQKLPLKIQNHLINLPDIRIKEIKKRMRQQKKKNQNSLLESSSYKDLYYVSSEYYDYVSKCLIWSNYYFFNYMSTTIVYSVKKRSYEYIQKEKSKINLFLEYAHNDIIEYIKDITYYFKLIVNKIESKRLFSEPVMLCFQLFSDHYLYLLKNILSILLIHIEKPVTRKSNRDLKKIFNCIKDQENITKNILDEFHSKNKIRYNPTEFLIYKFFSSIQYKQNIAHKYIIQSNINIISLMLKIFNYFHILVISLIFYLNLHSMYTLFIDLDIDDTLKFQHDQEFLNYFKRYQDFNNQLFDSFRSDDR
Protein: Large ribosomal subunit protein bL33c (50S ribosomal protein L33, chloroplastic) (P0C456)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Large ribosomal subunit protein bL32c
- Small ribosomal subunit protein bS16c
- Small ribosomal subunit protein uS8c
- Large ribosomal subunit protein bL36c
- Small ribosomal subunit protein uS11c
- Large ribosomal subunit protein uL14c
- Uncharacterized protein
- Small ribosomal subunit protein uS2c
- Small ribosomal subunit protein bS18c
- Small ribosomal subunit protein uS15c
Sequence:
MAKGKDVRIRVILQCVSCVRKGANEESAGISRYSTQKNRHNTPGQLELRKFCRYCRKHTIHAEIKK
Protein: Single-stranded DNA-binding protein (SSB protein) (Gp32) (Helix-destabilizing protein) (P03695)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Single-stranded DNA-binding protein that participates in viral DNA replication, recombination, and repair (Probable). Coats the lagging-strand ssDNA as the replication fork advances. Stimulates the activities of viral DNA polymerase and DnaB-like SF4 replicative helicase, probably via its interaction with the helicase assembly factor. Together with DnaB-like SF4 replicative helicase and the helicase assembly factor, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions and mediates homologous DNA strand exchange. Promotes also the formation of joint molecules. mRNA specific autogenous translational repressor.
Interaction partners:
Sequence:
MFKRKSTAELAAQMAKLNGNKGFSSEDKGEWKLKLDNAGNGQAVIRFLPSKNDEQAPFAILVNHGFKKNGKWYIETCSSTHGDYDSCPVCQYISKNDLYNTDNKEYSLVKRKTSYWANILVVKDPAAPENEGKVFKYRFGKKIWDKINAMIAVDVEMGETPVDVTCPWEGANFVLKVKQVSGFSNYDESKFLNQSAIPNIDDESFQKELFEQMVDLSEMTSKDKFKSFEELNTKFGQVMGTAVMGGAAATAAKKADKVADDLDAFNVDDFNTKTEDDFMSSSSGSSSSADDTDLDDLLNDL
Protein: E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (FXI-T1) (Protein deltex-1) (Deltex1) (mDTX1) (RING-type E3 ubiquitin transferase DTX1) (Q61010)
Organism: Mus musculus (Mouse)
Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86Y01}. Nucleus {ECO:0000250|UniProtKB:Q86Y01}. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear. {ECO:0000250|UniProtKB:Q86Y01}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 2
- Neurogenic locus notch homolog protein 3
- Neurogenic locus notch homolog protein 4
- E3 ubiquitin-protein ligase Itchy
- Notch-regulated ankyrin repeat-containing protein
- Delta and Notch-like epidermal growth factor-related receptor
- Probable E3 ubiquitin-protein ligase DTX2
- E3 ubiquitin-protein ligase DTX3L
Sequence:
MSRPGQGVMVPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPIAPAAPPAPPPPPPPLPPGGPPGALVVRPSATFAGAALWAAPATGPTEPAPPPGVPPRSPSAPNGAPTPGQNNLSRPGPQRSTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRNKSVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFADTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAMAKA
Protein: diguanylate cyclase (EC 2.7.7.65) (A0A0H2X3K2)
Organism: Xanthomonas campestris pv. campestris (strain 8004)
Interaction partners:
Sequence:
MAEQPEHPNRPRGGLRRLLPWGGAGTARPATLPSVLGERDGAGLAAHQLVPAKAKSGAHDPAAATALLIRLFSHAAHPEALLLAFAEGIASLHGELGDMGVRLSTAYAAGDWPGYGRALRQLIDKYIRTIDTGDSLAEGRTEAEQLRDLLRHALGNALATLLQRSPELAEEAQTLASALRHWRPGHELITLEQRLRELSHQIGLRAEDASEQQNLLLGLFDLLLENVGELLDDRSWLQGQISVVRQLIAGPMDVGSIEQARGTLREVIYKQGLLKQGIADSKTAMREMMVSFVDRLDGMATSTGEYHDRVAGYSQAIGDARSIPDLNRLLQDVLQDTAGVQAQALAARDELLSARRQVEEAEHRIASLEQELKDVAGLVREDQLTGALNRRGFEELFEREATRTQRSGQPLCVAMLDLDDFRRLNETHGHAGGDAALRHTVDVAKSVLRTTDAIARFGGEEFVLLLPDSTIFEASAAVIRLQRALAQRSLLHEDVRVFVSFSGGVAMRRTDEAQDEVIRRADRAMYDSKAAGKNRVISAD
Protein: Nudix hydrolase 23, chloroplastic (AtNUDT23) (EC 3.6.1.-) (ADP-ribose pyrophosphatase) (EC 3.6.1.13) (FAD diphosphatase) (EC 3.6.1.18) (P93740)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use FAD and ADP-ribose as substrates.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18815383}.
Interaction partners:
- Bifunctional riboflavin kinase/FMN phosphatase
- FAD synthetase 2, chloroplastic
- FAD synthetase 1, chloroplastic
- Purple acid phosphatase 4
- Purple acid phosphatase 8
- Purple acid phosphatase 7
- Purple acid phosphatase 3
- Purple acid phosphatase 17
- Flavin mononucleotide hydrolase 1, chloroplatic
- Chaperone DnaJ-domain superfamily protein
Sequence:
MLKAVQILGWSSGLTISQRLTKTRKSSTVSFISSSLNLSSVTSSSPRRIFSFKPTRMSSSLPGSDPVANSPTFVSVQSAGDVRKIKFCQWCGGPTKHEIPDGEEKLRAICTHCGKIAYQNPKMVVGCLIEHEGKVLLCKRNIQPSHGLWTLPAGYLEVGESAAQGAMRETWEEAGATVEVISPFAQLDIPLIGQTYVIFLAKLKNLHFAPGPESLECRLFALDEIPFDSLAFSSIYVTLNLYLEDLKKGKLKFHYGTINKRPGSSPSDIRAFSLDYHLQP
Protein: Putative N-acetyltransferase subunit ARD1 (Q9NFL8)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MQVRRATMEDMYQMQHCNLRCLPENYNLRYYLYHILSWPQLLYVQEDNNGNVVGYVLAKMEEEEHAEKVFGHITSIAVLRTHRRLGIASRVMNAALHEMEHEYDANFCSLHVRKTNDAALHLYQNTLNFRCANVESKYYVDEEDAYHMKRFFKGSNPGFYVTESRQLVRQPNTGAGAAAGSAAEASGQRPDKKNSVDKQKEQLELAAELLEEDLKSSGKGRRQPHQQHQKGGKHGKGKK
Protein: Probable trehalose-phosphate phosphatase H (AtTPPH) (EC 3.1.3.12) (Trehalose 6-phosphate phosphatase) (Q8GWG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance (By similarity).
Interaction partners:
- Trehalase
- Alpha,alpha-trehalose-phosphate synthase 1
- Probable alpha,alpha-trehalose-phosphate synthase 10
- Probable alpha,alpha-trehalose-phosphate synthase 2
- Probable alpha,alpha-trehalose-phosphate synthase 9
- Probable alpha,alpha-trehalose-phosphate synthase 11
- Probable alpha,alpha-trehalose-phosphate synthase 4
- Alpha,alpha-trehalose-phosphate synthase 5
- Probable alpha,alpha-trehalose-phosphate synthase 7
- Probable alpha,alpha-trehalose-phosphate synthase 3
Sequence:
MVRFIEENTKLVEKETGNKSNNDVTTTKKKALQDIIINNGVGLINSWVDSMRACSPTHLKSLLKQSSWLTEHPSALDMFEEILHLSEGKQIVMFLDYDGTLSPIVDDPDRAFMSRKMRRTVRKLANCFPTAIVSGRCIEKVYNFVKLTELYYAGSHGMDIKGPEQGSKYEQILQDSKSLLCQPATEFLPMIDEVYHKLVEKTKSTPGAQVENNKFCVSVHFRRVDENNWSDLANQVRSVMKDYPKLRLTQGRKVLEVRPIIKWDKGKALEFLLESLGYANCTDVFPLYIGDDRTDEDAFKVLRERRQGLGILVSKFPKETSASYSLQEPDEVMEFLQRLVEWKQLRSGA
Protein: Ion transport domain-containing protein (Olfactory channel) (G5EBV8)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Cyclic nucleotide-gated channel
- Transient receptor potential cation channel subfamily A member 1 homolog
- Transient receptor potential channel
- Cyclic nucleotide-binding domain-containing protein
- Guanine nucleotide-binding protein alpha-17 subunit
- Serpentine receptor class r-10
- Ion transport domain-containing protein
- Cyclic nucleotide-binding domain-containing protein
- Degenerin mec-10
- Degenerin mec-4
Sequence:
MGGGSSRNKTEPRGEGVKLAFDPDEKWSNLYREREKNHLYKWVAVRKGGELINIYERDGEEGVLKFAEEKLLTILYDEGQNPKLVTYSDYIKWKKGVNVQLGLSEESVDMQQSRFKEHYALWKLNKRGVEGENLIHLLLNREQQVCYEIARILLKRFPGMANDIYLGDEQFGQSALHLAIVHDDYETVSLLLNSKADVNARACGNFFLPEDFKLTNKITDYQGYAYYGEYPLAFAACFGNKDIYDLLIQFGANPNLQDSFGNTILHMCVINYSSSMYSYAVRHWAKPADPHVVNHAGFTPLTLATKLGRKQIFEEMLEIMKVEFWRFSDMTCSAYPLNTLDTIQPDGSTNYDSALMTVINGSTPEHLDMIGSEVIQRLLADKWKAFAQRKLIERLVLLIVQLITLSIVVYIRPTELPRLYMEDPQWDDYIRTACELLTILNCIFFVGYQQLGEIRTQGMRGYLRNLKTAPAKAVFCIANLFLLLCIPFRLMKKHEIEEALFVFALPGSWIFLLFFARSAKLTGPFVQMIYSMIAGDMIRFAIISAIFLVSFSQVFYFVGKDMDAKQKLEDTNPHACRISGYTIYTYNTFPETFITLFRASMGGYDYEEFSCANYQALTKTLFVLYMFVMPIMMINILIAMMGNTYTTVIAQAEKAWRQQYAQIVMVLERSVGKERLAASQLEYSIRLDQEGSSGMEVRGLMVIKQTKKTRARQRKQAIYNWKTIGRKVIHTIDKVGTEQAVLLLHGHDRLDRVYEDHVQPEKVPSRSRTPTRIGTTLNSSKRLKTTTMVVGAAVTNTHEVRTDEAVNSMLLSAPPSLSGEGATMDWQPSITPVEERSESKSQEDRSEASTPNLGIHRTTPKADSPIRVVEYSRTIRVRAADTIPSIELPNIPTKQTSSTPPHRAVSPRLRADMFRRHQQPASFDQSPPLPPTNDKSE
Protein: Protein teflon (Q7K4M4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Specifically required in males for proper segregation of autosomal bivalents at meiosis I. Expression is required in the male germ line prior to spermatocyte stage S4. May have a role as a bridging molecule maintaining adhesion to hold autosome bivalents together via heterochromatic connections.
Subcellular location: Nucleus {ECO:0000269|PubMed:11139508, ECO:0000269|PubMed:16816414}. Chromosome. Note=Male meiotic chromosomes. {ECO:0000269|PubMed:11139508, ECO:0000269|PubMed:16816414}.
Interaction partners:
- Something that sticks like glue, isoform A
- Stromalin-2
Sequence:
MSKFLDMLSGSQCVSLEKCGDVVVSTNDCMIALYCHFCRDLFTQLPEFLRHLQSNHSDVLHFTKEHNVYSVEELLSGEQGKAHEDAQSAGHNSSSGDSSSLMNSEDSRAIEGSEDNSDNSPMKPEQIGKQSEINLLAEVTNILLQTNDKELKPENGVFNRPRKKANNESSSLKICDLKSHTIARTSRKRMSMVKNRILRVLDSDLSAKLEIKPPEPNSKLSITEPIQEDNIPGTCFDTPTKPIPSSSQLSVRKSSLTEANQICTKYAEKKTAPTMPKLLNCVPKPILTSQQAHTNAEISEINETYHLAASQVTKTTKTFPVKITQIDILQPVKLPKTLITPINEEGVSDQVENSTNNINNAQSLPKENTKKFFKKRSELGIKAQGSPNKFFKIIKSKANPIIVKRVQTTSAKASTNKIQIRSNDKTNCFASEFNSTKIRKLKMENCVDLKSEDPCANTNTRLNKLATISSCEILKAVGLPAITDNPIEDTLLPDELETIRKKADQFIKIYRKYDSIWNYRKICPPAKPDFISQQIFALTREVNKTMLCNLANSDIKGIINQISVWHYNIYTQYIDLDTISENARYTLKLFSFLPVSFAYFCKCCDDIFILKKEYLKHLISHQVRFQCTKCIKVFKYKGYYEKHLRNAHS
Protein: V-type proton ATPase subunit c' (V-ATPase subunit c') (Proteolipid protein vma11) (V-type proton ATPase 16 kDa proteolipid subunit 2) (V-ATPase 16 kDa proteolipid subunit 2) (Vacuolar proton pump 16 kDa proteolipid subunit 2) (Vacuolar proton pump c' subunit) (Q9URZ8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
Subcellular location: Vacuole membrane {ECO:0000250|UniProtKB:P32842}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- V-type proton ATPase subunit d
- Probable V-type proton ATPase 20 kDa proteolipid subunit
- V-type proton ATPase subunit B
- V-type proton ATPase subunit E
- V-type proton ATPase subunit F
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit a
- V-type proton ATPase subunit H
- V-type proton ATPase subunit D
- V-type proton ATPase subunit c
Sequence:
MSSNLCPIYSSFFGFAGVCASMVFSCLGAGYGTALAGRGIAAVGAFRPEIVMKSLIPVVMSGIIGVYGLVMSVLIAGDMSPDNDYSLFSGFIHLSAGLAVGLTGVAAGYAIGVVGDRGVQSFMRQDRIFVSMVLILIFAEVLGLYGLIVGLILQTKTSNVCY
Protein: Dyschronic, isoform C (Q9VU98)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Interaction partners:
Sequence:
MRLGGSGIPYDGDPLTMSAAGNDYAELCDLGPSRWSARPYGYNATAAAAASFGLGPSMGGTQSSSSVPTGGSAGLSGHHLRSSGAPGPSSFEAEDIGMAFGMISPPPGSGPYVGSSAAAGGSRVGNSTSSLRGAGGRSGLYYSPPGTSYTIVERPHSPHYYFNSAGVPTKGGSLPGRGSAYLSSSPASHMAAGTAGTLPTSTAASGRSMGQHASSNGNKKRPISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWDAYSPTGTRARRKGQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPARDLPVTADDLEIIAATGRSPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQTGSNQSSSSLSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRGSETLLPEYEPDAEQELATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSAEQNGGSTTEQTHEHNPNVVPDHRGNLHITVKKTKPILGIAIEGGANTKHPLPRIINIHENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALIFLEA
Protein: TBC1 domain family, member 18 (F1LJ00)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQLKIVSNGDEQLEKAMEEILRDSEKRPSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQLILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQYPFPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL
Protein: Protein IQ-DOMAIN 4 (AtIQD4) (F4IUJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Nucleus, nucleolus {ECO:0000269|PubMed:28115582}.
Interaction partners:
- Glycine/proline-rich protein
- IQ-domain 29
- At1g23060/T26J12_16
- Tryptophan aminotransferase-related protein 3
- At5g61865
- Mitochondrial import inner membrane translocase subunit PAM16 like 2
- Mitochondrial import inner membrane translocase subunit PAM16 like 1
- Tryptophan aminotransferase-related protein 4
- Phosphatidylinositol 4-phosphate 5-kinase 3
- Mitochondrial import inner membrane translocase subunit TIM44-1
Sequence:
MGKNWLTCVSVACLSPGKDKKNQKPEKPKRKWSFGKQKSRESFDFPLEETPPVDPSPSSVHRPYPPPPPLPDFAPQPLLPPPSPPPPPPAYTINTRIYGESKESKNRQALALASAVAAEAAVVAAHAAAEVIRLTTPSTPQIEESKEETAAIKIQNAYRCYTARRTLRALRGMARLKSLLQGKYVKRQMNAMLSSMQTLTRLQTQIQERRNRLSAENKTRHRLIQQKGHQKENHQNLVTAGNFDSSNKSKEQIVARSVNRKEASVRRERALAYAYSHQQTWRNSSKLPHQTLMDTNTTDWGWSWLERWMASRPWDAESIDDQVSVKSSLKRENSIKSSPARSKTQKSASQSSIQWPVNNDTKSRKIEVTNRRHSIGGGSSENAKDDESVGSSSSRRNSLDNTQTVKSKVSVETTSNVSNAQTVKPKANVGAKRNLDNTKTLKSKSSVGTTGNLANTEAVKSKVNVGTTSMPKKEVVADKKKPPQMVLPKKRLSSSTSLGKTKKLSDSDKATTGVANGEKKRRNGGSS
Protein: Eukaryotic translation initiation factor 5B (Translation initiation factor IF-2) (Q586X2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 40S ribosomal protein S15, putative
- Eukaryotic translation initiation factor 1A, putative
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S23, putative
- 40S ribosomal protein S13, putative
- 60S ribosomal protein L2, putative
- 40S ribosomal protein S5, putative
- 40S ribosomal protein S14
- Small ribosomal subunit protein uS4
- 60S ribosomal protein L10, putative
Sequence:
MPPKGPKAAPKGAPARKGGPPAAMIAKLKQHMEKQKEEEERLRREREEEEKRLREEERLAEEQRRFEEEERARERQRRKEEERLARKMGTKESRNDVLERMAAAGFIVPDVEKVREQQKKEREAPRPKQQKQKPTQKQEEDAADERAAKAGHESDEDSLDLPVEDDGEVTEPTESDAEVDEEDWEAMMERDDRREQRKINNERIRKRRAEMVEERLKAKEARKRAKEEERRAKEHVLESVTKLRSPICCVLGHVDTGKTSLLDRIRATNVQGGEAGGITQQIGATFFPRESIVEATADLNQKYQHQLNVPGLLVIDTPGHESFTNLRSRGSSLCDIAILVVDIMHGLEPQTRESIRLLREKKCPFIVALNKVDRLYDWVAHKDMDIEQTLSLQKPNVRDEFSTRLVQVKQELLAEGLNSELYYHNKEVRKVVSIVPTSAKTGEGICDLILLEVQLVQQFMEGKVTYKDDLQCTILEVKPTTGYGFTIDAILINGELHEGDNICLCGQNGPVFTQIRALLTPQPMKELRVRGEYIHHKTMKAAMGIKIAANELEYVIPGSHLLVVRPGDDKEAVAKEVMKDANSITDQLSPDGVGVTVQSSTLGSLEALLSFLNKMKIPVASASIGPLHKRHMINVLSMKRKSPRHAVVLAFDVEISDDARDIAKKNDIDMFEAKIIYHLFDMFTRYINEYEKREKDKARAIAVFPVQLTILDDAIHNTDPIILPVKVKCGQLHPGTPLAFMRGDTPHLIGRVMSLERDKKSITVGRVGCECSVKINSGESGMTFGRQFDKSDELFSLISRPSVNAIKLFKDELTEDDINLLATLIKVLKVPPR
Protein: Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) (P97440)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (By similarity). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (By similarity). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18036581}. Nucleus {ECO:0000269|PubMed:18036581}. Note=Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase. Through the S phase, partially redistributes to the cytoplasm. Binding to histone mRNA is necessary for cytoplasmic localization. Shuttles between the nucleus and the cytoplasm. Imported in the nucleus by the Importin alpha/Importin beta receptor (By similarity). Polyribosome-associated. {ECO:0000250|UniProtKB:Q14493}.
Interaction partners:
- 3'-5' exoribonuclease 1
- U7 snRNA-associated Sm-like protein LSm11
- MIF4G domain-containing protein
- Eukaryotic translation initiation factor 4E
- U7 snRNA-associated Sm-like protein LSm10
- Nuclear cap-binding protein subunit 1
- Heterogeneous nuclear ribonucleoprotein Q
- Y-box-binding protein 1
- Small nuclear ribonucleoprotein-associated protein B
- Regulator of nonsense transcripts 1
Sequence:
MACRPRSPPGYGSRRDGGASPRSPARWSLGRKRRADGRDRKPEDSEEGELQTADHRPESFTTPEGHKPRSRCSDWASAVEEDEMRTRVNKEIARYKRKLLINDFGRERKSSSGSSDSKESMSSVPADVETDESVLMRRQKQINYGKNTIAYDRYIKEVPRHLRQPGIHPRTPNKFKKYSRRSWDQQIKLWKVALHFWDPPAEEGCDLQEIQPVDLGEMETEFTESSSESQTSSQDNFDVYAGTPTKVRHVDCQVEDEFDLEACLTEPLKDFSAMS
Protein: LexA repressor (EC 3.4.21.88) (A0L9E2)
Organism: Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
Function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Interaction partners:
- Protein RecA
- Uncharacterized protein
Sequence:
MTDRKEHKMKPGRRPTEGMTPSQERIMQVIRNAIDRDGLPPTVKEIAEALGMKTPSAHEQVQKLVKKGFIRRTPRKARSIEIVEQSPEEEPVEKKPDVARLVPVPIIGEVAAGIPILAVENHIGELLMDSRTARGPCFALKVKGDSMIDAEIFEGDYVVVRHQALAENGDIVVAILDGEATVKRLYISEETIELRPENRSYQPIVVPPGGDIRILGKVLAVRGHGAANNNE
Protein: dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (Q8IEA6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 2-oxoglutarate dehydrogenase E1 component
- Dihydrolipoyl dehydrogenase
- Dihydrolipoyl dehydrogenase, apicoplast
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- 3-methyl-2-oxobutanoate dehydrogenase
- 2-oxoisovalerate dehydrogenase subunit alpha
- Pyruvate dehydrogenase E1 component subunit beta
- Acetyl-CoA acetyltransferase, putative
- Glycine cleavage system H protein
Sequence:
MTKNLVFRLNKSLLHHVKSFNRTFLNHKYNSNANIEGSLKRYFSIETIKVPRLGDSITEGTINEWKKKVGDYVKADETITIIDTDKVSVDINSKVSGGLSKIFADVGDVVLVDAPLCEIDTSVEPPEDICKTKEEVGESKNNENNYTFNQLNRDIKDEAHIKDEVSKNEKDIFVKDPICFGNDYESINERTERRVRMLPIRKRIAERLKESQNTCALLTTFNECDMSKAMLLRSELNDIFQKKYSCKLGFVSLFMYASTLALKKMPNVNAYIENDEIVYKNYIDISVAVATPNGLTVPVIRNCQNKNLPQLELALSDLATKARSNKLSIDDFSGGTFTISNGGVFGSMLSTPIINMPQSAILGMHTIKNRPVVVNNEIVIRPIMYLALTYDHRLLDGREAVQFLCAIRDYIENPNLMLIDC
Protein: TIAM Rac1 associated GEF 1 (D3ZWV8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Cell division control protein 42 homolog
- small monomeric GTPase
- Ras-related C3 botulinum toxin substrate 1
- small monomeric GTPase
- CD44 antigen
- Partitioning defective 3 homolog
- GTPase HRas
- GTPase NRas
- Serine/threonine-protein kinase PAK 1
- Ankyrin-3
Sequence:
MGNAESQNVDHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKAIHRNSEVSTRSSSTPSIPQSLAENGLEPFSQEGALDDFGDPIWVDRVDMGLRPVSYTDSSVTPSVDGSIVLTAASVQSMPDSEESRLYGDDAAYLAEGGRRQRPYTSNGPTFMETASFKKKRSKSADIWREDSLEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETGASPRQLSTCQRANSLGDLYAQKNSGVKANGGPRNRFSSYCRNLVSDIPDLAKHKMPPAAVETPTYSNYNTLPCRKSHCLSEGATNPQISLSKSMQGRRAKTTQDVNTGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPPTGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSVPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACAAAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDAKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLGFASRPTKLASGTLGVARVGTCDKHGCQRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPTINQVFGEGTDAVKRSLEGIFDDSVPDGKREKEVVLPSVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKAHQLDHSAHYLRLKFLMENKMQFYVPQPEEDIYELEAIYDGILIKIEICPKVTQNIHIEKSDAAADNYGFLLSSVDEDGVRRLYVNSVKETGLASKKGLKAGDEILQINNRAAGTLNSSMLKDFLSQPSLGLLVRTYPEPEGGVELLENPPHRVDGPVDLGESPLTFLTSNPGHSLSSEQGSSAETAPEEGEGPDLESSDETDHSSKSTEQVTAFCRSLHEMSPSDSSPSPQDATSPQLATTRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPRQQHSSTLESYLIKPIQRVLKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTSVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYEEWDPFRFRHMIPTEALQVRALPSADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKSVHSILRDKHRRQLLKTESLPSAQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLARNRFTIDSDAISASSPEKEPQQPPGGGDTDRWVEEQFDLAQYEEQDDIKETDILSDDDEFCESAKGASVDIDLQEQLQAASISQRARGRKTLDSHASRMTQLKKQAALSGINGGLESASEEVIWVRREDFAPSRKLNTEI