wanglab/gogpt-training-data huggingface dataset:
Protein: TBC1 domain family member 7 (Q385K7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004656}.
Interaction partners:
- Small GTP-binding protein Rab1, putative
- Small GTP-binding protein RAB6, putative
- Vacuolar protein sorting 33, putative
- AP-3 complex subunit delta
- Phosphoinositide-binding protein, putative
- Exocyst complex component Sec10-like alpha-helical bundle domain-containing protein
Sequence:
MKGDDSVHGDATTDLQSPREDVVTMASDGDHMIRKSLKDSNSDAPIFGELLDAEVTVNPMKLREASRAGIPPLYRSAVYRYLLGVSFVDKSREMTVERMQEKDFEQLEATFAQIVACDEKGGSTRCHASHALFAANCDTMMTRRESKFVNGYRCSDRFSTFGCTTWLAVLARLKYMPQFVGNHERRQRIESAWRALYVCHSEATPDEVNYIFELAIAFEAVYSTARDIYFSVESIYHLLTHHNNVLQNKQCLQHHCGVFLMLFRATNFELYRHFVTEGVSVLDWVPGILTTLLAGRLHVEDLLRLWDVYFADAQNCLGFPLHPYVCLAILAEMTEVLIECEKSGIIELLQNMPRMRMGCIIQRAIALKESVLSQGLL
Protein: Lutropin subunit beta (Lutropin beta chain) (Interstitial cell-stimulating hormone) (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta) [Cleaved into: LH beta-1; LH beta-2; LH beta-3] (P01231)
Organism: Ovis aries (Sheep)
Function: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The LH alpha 3/LH beta 3 heterodimer was shown to have potent renotropic and weak gonadotropic activity.
Subcellular location: Secreted.
Interaction partners:
- Lutropin-choriogonadotropic hormone receptor
- Glycoprotein hormones alpha chain
- Uncharacterized protein
- Nuclear transport factor 2.
- Paralemmin-1
Sequence:
MEMLQGLLLWLLLGVAGVWASRGPLRPLCQPINATLAAEKEACPVCITFTTSICAGYCLSMKRVLPVILPPMPQRVCTYHELRFASVRLPGCPPGVDPMVSFPVALSCHCGPCRLSSTDCGGPRTQPLACDHPPLPDILFL
Protein: Calaxin (EF-hand calcium-binding domain-containing protein 1) (Q9D3N2)
Organism: Mus musculus (Mouse)
Function: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Regulates ciliary and flagellar motility and is required for cilia-driven determination of body laterality.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:31240264}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9HAE3}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9HAE3}.
Interaction partners:
- Piercer of microtubule wall 1 protein
- Outer dynein arm-docking complex subunit 2
- EF-hand domain-containing family member C2
- Outer dynein arm-docking complex subunit 4
- Armadillo repeat-containing protein 3
- Outer dynein arm-docking complex subunit 3
- Cilia-and flagella-associated protein 96
- IQ motif and ubiquitin-like domain-containing protein
- Outer dynein arm-docking complex subunit 1
- Piercer of microtubule wall 2 protein
Sequence:
MNRKKLQKLTDTLTKNCKHFDKFEVKCLITLFYNLVGDVAERPGVVTGLDRNVFRNILHVTFGMTDDMIMDRVFRGFDKDNDGCISVSEWIHGLSLFLRGTLDEKMKYCFEVFDLNGDGFISKEEMFHMLKNSLLKQPSEEDPDEGIKDLVEITLKKMDHDHDGKLSFVDYEKAVREENLLLEAFGPCLPDPKSQMEFEAQVFKDPNEFNDM
Protein: Uncharacterized protein C1450.03 (Q9Y7N1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable U3 small nucleolar RNA-associated protein 18
- Periodic tryptophan protein 2 homolog
- U3 small nucleolar RNA-associated protein 21 homolog
- U3 small nucleolar RNA-associated protein 17
- U3 small nucleolar RNA-associated protein 4
- U3 small nucleolar ribonucleoprotein protein mpp10
- Uncharacterized WD repeat-containing protein C3D6.12
- rRNA processing protein rcl1
- Nucleolar protein 58
- U3 small nucleolar ribonucleoprotein protein imp4
Sequence:
MAATTGNIIKFEENADSKDLLEQCLNCSDVGVVSNTVRNMDGTIAADLARTLIPAMLINMQPSLAIWLHWIIVTHGGYLTTVMDLQDSLVQLHEKLVQSAHLMTKIFSLSGKLNMVLSQEEMRQRRLDFSSEDGEEEEENDYIDEDVDEAGYDIEVVDEAENDDMDNDLEANADAFDESNLEASLSPNAELSPRKSHIDHDFVIPEDEMLSEEEEQEVEKQILPKFVVPESPRKTSRKSR
Protein: Calcium-binding protein 1 (CaBP1) (Caldendrin) (O88751)
Organism: Rattus norvegicus (Rat)
Function: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling (By similarity). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15095872}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15095872}. Note=Occurs in both the cytoplasmic and cytoskeletal compartment of cell somata and dendrites.
Interaction partners:
- NMDA receptor synaptonuclear signaling and neuronal migration factor
Sequence:
MSSHIAKSESKTSLLKAAAASGGSRAPRHSSARDPGLRGRRLPGPCPDSPATCGDPSSRRPLCRPVPRDEGARGSRRGLPQAHCRPRETLPPARGRDGEERGLAPALSLRGSLRSRGRGDPAPAGTPEADPFLHQLRPMLSSAFGQDRSLRPEEIEELREAFREFDKDKDGYINCRDLGNCMRTMGYMPTEMELIELSQQINMNLGGHVDFDDFVELMGPKLLAETADMIGVKELRDAFREFDTNGDGEISTSELREAMRKLLGHQVGHRDIEEIIRDVDLNGDGRVDFEEFVRMMSR
Protein: LON peptidase N-terminal domain and RING finger protein 3 (RING finger protein 127) (Q496Y0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MESVRIEQMLSLPAEVSSDNLESAERGASAAQVDMGPHPKVAAEGPAPLPTREPEQEQSPGTSTPESKVLLTQADALASRGRIREALEVYRQLSERQQLVAEQLEQLVRCLAEKVPQGEALAPAPPDEGSTASGTVAAEETGAAAAAAATEVWDGFKCRKCHGFLSDPVSLSCGHTFCKLCLERGRAADRRCALCGVKLSALMVATGRARGARRAGQQPPPPLRVNVVLSGLLGKLFPGPARASQLRHEGNRLYRERQVEAALLKYNEAVKLAPNDHLLYSNRSQIYFTLESHENALHDAEIACKLRPMGFKAHFRKAQALATLGKVEEALREFLYCVSLDGKNKRARCEAQRDNLELPHCSSQEEAAARGDGSSLMDPAKVKGDGQQHHMKDQEEEEEKWDATSPKAASSKTGKCQEKKRKHCQIESQEETGMPNKASKQDPPTDQGDKPALSLPLASFDASDLECALCMRLFYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDGLSQCLASRKYSKNVIMEELIAKFLPEELKERRKLYEEEMEELSNLNKNVPIFVCTMAYPTVPCPLHIFEPCYRLMIRRCIETGTRQFGMCLGDPVKGFAEYGCILEIRNVQFFADGRSVVDSIGKRRFRVLHQSQRDGYNTADIEYIEDQKVQGEDCAELMGLHNCVYQQASLWFHSLKLSLKNRILNHFGPMPEKDADPQMNPNGPAWCWWMLAVLPLESRAQLPFLAMRSLKDRLNGIRRVLAFISRNQN
Protein: Kalirin RhoGEF kinase b (EC 2.7.11.1) (Zgc:136817) (Q1RLV0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MEIIKDPSAQEDKTPERGSFPVLGSDTPSDQTPRDPETEQKNKALRGRMFVLNEMVQTERDYVKDLGVTVEGFMRRIGEKGVPEDMTGKDKIVFGNIHQIYDWHKEFFLCELEKCLQDHDKLAELFIKHERRLHMYVIYCQNKPRSEFVVAEYDKYFEGVQQEINSRLAISDYLIKPIQRITKYQLLLKDFLKYSTKAGLDCKEIEKAVELMSLVPKQCNDMMNLGRLQGYEGKLTAQGKLLQQDTFFVTEQDSGVLSRSKERRVFLFEQIVIFSELLRKGSSTPGYQFKKSIKVSYLSMEEQVESDPYKFVLLCRGSSERLTLQAANVDIKKEWVQSIRELLDMQINFLTALQNPQAALTSQLSNSNRSSSSQPSTPLKPNTAPNGSPAQKNNKHAEEDLDEGECNGLSSVLVTQDYNAVKEDEICVVVGEKVQIMASNQQNMCLVYRPANSQSPAAEGWVPGHVLSSTR
Protein: Transmembrane protein 130 (G3V0E7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEKGLSSTIRVVGHVPGEFPVSVWVTAADCWMCQPVARGFVVLPITEFLVGDLVVTQNTSLPWPSSYLTKTVLKVSFLLHDPSNFLKTALFLYSWDFGDGTQMVTEDSVVYYNYSIIGTFTVKLKVVAEWEEVEPDATRAVKQKTGDFSASLKLQETLRGIQVLGPTLIQTFQKMTVTLNFLGSPPLTVCWRLKPECLPLEEGECHPVSVASTAYNLTHTFRDPGDYCFSIRAENIISKTHQYHKIQVWPSRIQPAVFAFPCATLITVMLAFIMYMTLRNATQQKDMVENPEPPSGVRCCCQMCCGPFLLETPSEYLEIVRENHGLLPPLYKSVKTYTV
Protein: DnaJ protein homolog XDJ1 (P39102)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16689936, ECO:0000269|PubMed:16823961}.
Interaction partners:
- J protein JJJ2
- Pre-mRNA-splicing factor CWC23
- Auxilin-like clathrin uncoating factor SWA2
- Zuotin
- Diphthamide biosynthesis protein 4
- J domain-containing protein 1
- ER-localized J domain-containing protein 5
- Mitochondrial DnaJ homolog 2
- Mitochondrial import inner membrane translocase subunit TIM14
- Heat shock protein SSA3
Sequence:
MSGSDRGDRLYDVLGVTRDATVQEIKTAYRKLALKHHPDKYVDQDSKEVNEIKFKEITAAYEILSDPEKKSHYDLYGDDNGAASSGGANGFGDEDFMNFFNNFFNNGSHDGNNFPGEYDAYEEGNSTSSKDIDIDISLTLKDLYMGKKLKFDLKRQVICIKCHGSGWKPKRKIHVTHDVECESCAGKGSKERLKRFGPGLVASQWVVCEKCNGKGKYTKRPKNPKNFCPDCAGLGLLSKKEIITVNVAPGHHFNDVITVKGMADEEIDKTTCGDLKFHLTEKQENLEQKQIFLKNFDDGAGEDLYTSITISLSEALTGFEKFLTKTFDDRLLTLSVKPGRVVRPGDTIKIANEGWPILDNPHGRCGDLYVFVHIEFPPDNWFNEKSELLAIKTNLPSSSSCASHATVNTEDDSNLTNNETISNFRIIHTDDLPEGIRPFKPEAQDSAHQKARSSYCCIQ
Protein: Regulatory protein rop (RNA one modulator) (ROM) (P03051)
Organism: Escherichia coli
Function: Regulates plasmid DNA replication by modulating the initiation of transcription of the primer RNA precursor. Processing of the precursor of the primer, RNAII, is inhibited by hydrogen bonding of RNAII to its complementary sequence in RNAI. ROP increases the affinity of RNAI for RNAII and thus decreases the rate of replication initiation events.
Interaction partners:
Sequence:
MTKQEKTALNMARFIRSQTLTLLEKLNELDADEQADICESLHDHADELYRSCLARFGDDGENL
Protein: Cag pathogenicity island protein (Cag6) (O25261)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- Cag pathogenicity island protein
- VirB11 homolog
Sequence:
MELGFNEAERQKILDSNSSLMGNANEVRDKFIQNYASSLKDSNDPQDFLRRVQELRINMQKNFISFDVYYNYLNNLVLASYNRCKQEKTFAESTIKNELTLGEFVAEISDNFNNFMCDEVARISDLVASYLPREYLPPFIDGNMMGVAFQILGIDDFGRKLNEIVQDIGTKYIILSKNKTYLTSLERAKLITQLKLNLE
Protein: Effector Vd424Y (EC 3.2.1.8) (Endo-1,4-beta-xylanase) (G2X4G0)
Organism: Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137) (Verticillium wilt)
Function: Secreted effector that localizes to the host nucleus to contribute to the virulence process. Induces host innate immunity responses; triggers BAK1-and SOBIR1-dependent cell death, salicylic acid signaling and jasmonic acid signaling.
Subcellular location: Secreted {ECO:0000269|PubMed:34233072}. Host nucleus {ECO:0000269|PubMed:34233072}.
Interaction partners:
Sequence:
MVSFTSLLAAFSVVSGVLTSPIAVVPEVNTALAKRTPSSTGTSGGFYYSFWTDTPNSVTYTNGDAGKFSVSWKNNNGNHVGGKGWRTGSARTIKYSGSYKPNGNSYLAIYGWTRSPLIEYYIVESFGTYNPSTGATSKGQFTVDGSVYDLYTSTRTNAPSIEGTRTFTQFWSVRRTKRTSGSVNTGAHFAAWKKAGMNLGSHDYQILAVEGYKSSGSATMTVS
Protein: UDP-xylose and UDP-N-acetylglucosamine transporter (ER GDP-fucose transporter) (Solute carrier family 35 member B4 homolog) (Q9W429)
Organism: Drosophila melanogaster (Fruit fly)
Function: Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc), GDP-fucose and UDP-xylose. Functions redundantly with nac in the O-fucosylation of Notch, positively regulating Notch signaling. Involved in the biosynthesis of heparan sulfate-glycosaminoglycan (HS-GAG) and in Dpp signaling in the wing imaginal disk.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19948734}; Multi-pass membrane protein {ECO:0000269|PubMed:19948734}.
Interaction partners:
- UDP-sugar transporter UST74c
- GDP-fucose transporter, Golgi
- AMP deaminase
- Adenosine 3'-phospho 5'-phosphosulfate transporter 1
- UDP-galactose transporter senju
Sequence:
MALNLKALLGMLFVFIGCCSNVVFLELIIQIDPGAGNLITFAQFLFIALEGLVFTSKFFTVRPKIALKDYVILVALFFGANVCNNYAFNFNIPMPLHMIFRSGSLMANMIMGIVLLKKRYNLRQYSSVAMITAGIILCTLVSSGDVKDNTHHSLKVDTSYSDFFWWTVGIGLLTIALLVTAYMGIYQEVIYKKYGKHPSEALFFTHMLPLPGFLIMAGNIVQHFGIAWSSEPVAVPLLGAIGLEWKFPLMLFYLLCNVVTQYVCISAVYVLTTECASLTVTLVVTLRKFVSLLFSIIYFRNPFTLNHWVGTILVFFGTILFANVINQVRDAYRARSSRKTHFDTAPLAKKVE
Protein: Zinc finger protein 44 (M0R160)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALCYGTFWGYPKMLEAANLMEGLVDIGPWVTLPRGQPEVLEWGLPKDQDSVAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNLNCIGMKWENQNIDDQHQNLRRNPRLSETWLQNFILIHYGHLVALSDGGLLQFSTGQGLPVTQAGVQ
Protein: Integrin alpha-11 (Q9UKX5)
Organism: Homo sapiens (Human)
Function: Integrin alpha-11/beta-1 is a receptor for collagen.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Integrin beta-1
- Integrin beta-5
- Integrin beta-3
- Integrin beta-8
- Integrin beta-7
- Integrin beta-6
- Integrin alpha-5
- Integrin alpha-2
- Integrin alpha-10
- Integrin alpha-1
Sequence:
MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGAPLETNGYQKTGDVYKCPVIHGNCTKLNLGRVTLSNVSERKDNMRLGLSLATNPKDNSFLACSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINILKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVLGYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDGVLLGAVGAYDWNGAVLKETSAGKVIPLRESYLKEFPEELKNHGAYLGYTVTSVVSSRQGRVYVAGAPRFNHTGKVILFTMHNNRSLTIHQAMRGQQIGSYFGSEITSVDIDGDGVTDVLLVGAPMYFNEGRERGKVYVYELRQNLFVYNGTLKDSHSYQNARFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELATGLQYFGCSIHGQLDLNEDGLIDLAVGALGNAVILWSRPVVQINASLHFEPSKINIFHRDCKRSGRDATCLAAFLCFTPIFLAPHFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAVLLSSGQELCERINFHVLDTADYVKPVTFSVEYSLEDPDHGPMLDDGWPTTLRVSVPFWNGCNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFFRAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKPNSSLERYDGIGPPFSCIFRIQNLGLFPIHGMMMKITIPIATRSGNRLLKLRDFLTDEANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINCNIRLVPNQEINFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPTPKVLE
Protein: CMRF35-like molecule 9 (CLM-9) (CD300 antigen-like family member G) (Triggering receptor expressed on myeloid cells 4) (TREM-4) (CD antigen CD300g) (Q6UXG3)
Organism: Homo sapiens (Human)
Function: Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q1ERP8}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q1ERP8}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q1ERP8}. Note=Transcytoses across the cytoplasm. {ECO:0000250|UniProtKB:Q1ERP8}.
Interaction partners:
- L-selectin
- Endomucin
Sequence:
MRLLVLLWGCLLLPGYEALEGPEEISGFEGDTVSLQCTYREELRDHRKYWCRKGGILFSRCSGTIYAEEEGQETMKGRVSIRDSRQELSLIVTLWNLTLQDAGEYWCGVEKRGPDESLLISLFVFPGPCCPPSPSPTFQPLATTRLQPKAKAQQTQPPGLTSPGLYPAATTAKQGKTGAEAPPLPGTSQYGHERTSQYTGTSPHPATSPPAGSSRPPMQLDSTSAEDTSPALSSGSSKPRVSIPMVRILAPVLVLLSLLSAAGLIAFCSHLLLWRKEAQQATETQRNEKFCLSRLTAEEKEAPSQAPEGDVISMPPLHTSEEELGFSKFVSA
Protein: Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) (Q4KLN6)
Organism: Rattus norvegicus (Rat)
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Inhibits Wnt signaling (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P31350}. Nucleus {ECO:0000250|UniProtKB:P31350}. Note=Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells. {ECO:0000250|UniProtKB:P31350}.
Interaction partners:
- Ribonucleoside-diphosphate reductase
- Adenylate kinase 9
- ribonucleoside-diphosphate reductase
- Nucleoside diphosphate kinase 6
- UMP-CMP kinase
- Nucleoside diphosphate kinase homolog 7
- Nucleoside diphosphate kinase A
- Guanylate kinase
- Nucleoside diphosphate kinase B
- Nucleoside diphosphate kinase
Sequence:
MLSVRAPLATIADQQQLHLSPLKRLSLADKENTPPTLSSARVLASKAARRIFQDSAELESKAPTKPSIEEEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDSKEREYLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEQRVKEIITNSVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSNSTENSFTLDADF
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (E9PEW0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTYESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKRQDSGTMKKPHTTEEIGVPISRNGSTLGLKSQNGCIPPKLPSGSPSPKLSQTPTHMPTILDDPGKKVKKPAPPLPTGMG
Protein: Protein HBS1 (EC 3.6.5.-) (Q9W074)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (By similarity). In the presence of pix and pelo, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (By similarity). Together with pelo and in presence of pix, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (By similarity). Together with pelo, required for transposon silencing in the ovary and testis. Together with pelo, promotes meiosis and spermatid individualization during spermatogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:30824860}.
Interaction partners:
- Protein pelota
- Combover, isoform A
- Csl4
- Ribosomal RNA-processing protein 42
- LD23303p
- FI07225p
- Exosome complex component RRP45
- FI06805p
- LP07472p
- Exosome complex component RRP4
Sequence:
MSRHRIVRTMDYNDEYDGYDDIYGHSVEDEHCISPTDAQQWLYDRARGQQSISAFISKNKDIQEEEADEDEDEDAAFAKARRDSESFQMPQLDEIEQAKLSSCVDEVRSVVGDAVSERRIVETSMKFDYDMQKILDEILNEETNKSAKPAVNKMKAPAAPVLPKTVSKTVPTPPPKISLKEPRRGFEIPSPKVPSSPVVSGRNTPVDISAGDDISRSSATVFKVSKEQAVRNARQLYEKERADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGEFESGFELGGQTREHAILVRSLGVNQLGVVINKLDTVGWSQDRFTEIVTKLKSFLKLAGFKDSDVSFTPCSGLTGENLTKKAQEPALTNWYSGRHLLDVIENFKIPERAIDRPLRMSVSDIYKGTGSGFCISGRVETGVLCLNDKVLVGASREQAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVGCIISDPQTPIPVTTRFQARIIVFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASIHKSTGEVVKKKPRCLGNNSCALVELETSRPICIERYADFKELGRVMLRVAGVTIAAGMVTKIR
Protein: C-C motif chemokine 5 (SIS-delta) (Small-inducible cytokine A5) (T-cell-specific protein RANTES) (P50231)
Organism: Rattus norvegicus (Rat)
Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Subcellular location: Secreted.
Interaction partners:
- C-C chemokine receptor type 5
- C-C chemokine receptor type 3
- Macrophage inflammatory protein-1 alpha receptor
- C-C motif chemokine
- C-X-C chemokine receptor type 3
- C-C motif chemokine ligand 24
- Platelet factor 4
- C-C motif chemokine ligand 26
- C-C motif chemokine ligand 27
- C-X-C motif chemokine 10
Sequence:
MKISAAASLTVILVAAALCTPVPASPYGSDTTPCCFAYLSLALPRAHVKEYFYTSSKCSNLAVVFVTRRNRQVCANPEKKWVQEYINYLEMS
Protein: Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (F1SPH6)
Organism: Sus scrofa (Pig)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Endosome {ECO:0000256|ARBA:ARBA00004177}. Nucleus, Cajal body {ECO:0000256|ARBA:ARBA00004408}.
Interaction partners:
- Cyclin A1
- Cyclin E2
- G1/S-specific cyclin-E1
- Cyclin D1
- Cyclin-dependent kinase inhibitor 1
- S-phase kinase-associated protein 2
- Cell division control protein
- Retinoblastoma-associated protein
- Cellular tumor antigen p53
- G2/mitotic-specific cyclin-B1
Sequence:
MENFQKVEKIGEGTYGVVYKAKNKVTGEVVALKKIRLDTRVMPENVQSERLGKRKEASDLGSRTPRGVGFCRKRETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHARCCGEHRRNGRHSLCPLCSYLEVAASQGGGMTAVSTPHPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Protein: Intraflagellar transport protein 172 homolog (Osmotic avoidance abnormal protein 1 homolog) (Outer segment 2) (Q9W040)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the maintenance and formation of cilia.
Subcellular location: Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Intraflagellar transport 52
- Tetratricopeptide repeat protein 30 homolog
- Intraflagellar transport protein 57 homolog
- No mechanoreceptor potential B, isoform D
- Outer segment 5
- Intraflagellar transport protein 122 homolog
- Clusterin associated protein 1
- TRAF3-interacting protein 1
- GH11140p
- Intraflagellar transport protein 46 homolog
Sequence:
MQLKYLRTLLEGQEQIQRIAGLAWSPNQQRLAIATADRHILLYDDAGERRDKFSTKPANPANGKNSYVIRGLAFSPDSTKLAVGQSDSIVYVYKLGESWNDKKVICNKFPQASAVTALIWLTSGSIIAGLEDGKVRALHSKSNKSQSLYGGDSICISLAANTKGTGFLSGHNDGTIIRYFMTDEATEPLGRVVQHPVPPFALAWPQGGFCAGGCDQRIVFYDSMGRQLRTFDHSRTEGEREFTVAACSPNGQAVAFGSFDRIRIFAWSPRQGAWSESATKEVACLYTLSSLLWRRDGARLALGSVSGAVLLFESVLRRTVWQDKFELIFVAPSQLLVRSLTEPSQALTIESQLGLEIDDVRIMGRDNYLVARTEESLILCDLTRNLSSEVPWTASGHHERFYFENPTVCLIFNVGELSLVEYGENSILGSVRTEFVNPHVISVRLNERGNAKENKKLAFLLDAKTICVVDLISRMTSGQISHETKIDWLELSETAHKLLFRDKKLRLILVDNYTGKKQTLLSNISFVQWVPQSDVVVAQSNSNLAIWYNIDLPEHVTMQSVRGEAIEVLRENGRTVVRSQDGPSEHNYQLDEGLVEFGTAVNDSDFGRAVHFLESLGDKPAAKAMWHNLALIALEDGNLRVAQRCYAALGNVSKAYYLAGMIQQADEFEESSGSPGILCPEVRAKLALLGSDLRTAERIYLEQGDIESALKMYQQLGMWDEAVALAERRGYNRIAELKQQHMDYLLSSEQQEKAGQVLEEQGDLQQAMSLYMKANKPARAARLALKTPHILQDEQVMLQVTEGLVRSELYELAGDIAHRLSRPEAALALYRKGGAYARALEIGRVVAPQEVTALEEEWGDWLVSRKQLDASINHYIEAGATQKALEAAVGAKQWRKAVQIAKVLDEPELIQRYAVDLAKHLAFAGDLDGAEDMLVRANLHKDAIELLNRHGKWERAYLIGEKHLKAEQVRELFVQLAGTLEEQGKFRDAEKVLIAVNEPDLAIAMYKRRELYDSMIRLVERYHKDLLDSTHLHLARQLESRGKLKNAEMHFVASGDWKSAVHMYCSSGRWEDGYRVAKLKGTEGASQQVAYMWAKSMPTEGAVRLLSKLGLLDTAVGFACDSGQFEFAMELCKFAGKPTDEVHLKIAMSLEDEGKFEAAEAEFLKANKPREAILMYQHAGDWQAALNVAENHLPDAVGEVLIGQASAALETSNYKDYEALLLRAHRPDLIIEHYKQESLYEDALRIAEEHYPSALNDLRRLQAQLQRGQAQAQAGEDAASISRSYLQKAAEFAKKEQFRKAAECLMQIDSSNAEDASTLERALLRAAEICNQFLEGQDAQELAQSLGPRLLAIKQIGPAAQLYLAADMPKQAVDVFIKTEQWSKARRLAKEIDPDLQLLAYVEQQQKASLKHEGNIEQLADIDIVSALDLLAEHGEWQRCLEKAKGLNPALLQKYVAVYAAQLIREGNCTTALGLYLSYGAPPIEAHFNIYTRIALDCLALREEQTERGTTWRQLRDFLFRLLQSLKATPAQSQTKFAASMEQFLLIAHYYATRAACKEVQALQPVALRLSLALLRHTDLLPVDKGFYEAGMDLRQAGREAEAFVMLNHYLDVCEAIEEGSGQLVDHSDLASTDFPSSVPLPEDIHLKNDPSLHEEVREWVLAVSMDQQVDQQLPTDDRGLYESSLGPNDLPCMLSGFPVRGRQPVTFQGSSNQVNRDVWSKFSVALKMSPGSGIADIISFTEKWQGAANYVMH
Protein: Hym1p (Q5AHK0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- non-specific serine/threonine protein kinase
- Sog2p
- CBK1 kinase activator protein MOB2
- Serine/threonine-protein kinase CBK1
- Cas4p
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Sec63 complex subunit
Sequence:
MAFLFKRNPKTPPELVRALNDQVSKLDYASPDNAKKYQDECARYLKNMKVILHGDDEVEPQPDQITQLAQEIYSTDCLYYLVVNLRKLDFDSRKDVVILFSTLLRRTMANKSPTVDYLVHSKPEIITMLIKGPENLEIGLICGQILRDCIKFEVINRFVLYSPSFYNFFKYVQIPTFEIATDAMMTLHELLTTHRKLVSEFLGNNYDVFITAINKLITSKNYVTKRQSVKLLNELVSQRSNQQFLSKFFDDANNLKLTMLLLSDKSKNLQLEGFHTLKFFVANPKRSQKVTDILIKNKANFIEFFKTFDIASFHDSNIIEERDYTLGEIKNLPDRIH
Protein: DOT1 like histone lysine methyltransferase (F6S070)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGVFTHAVPSASAHPFGAGVGSGAVCSSATLGLSPLQAAASTSASSFQAAASVETRPPPPPPLLPPQHLGRPPAGPPVLHAPPPPNVALPPPPALLASNPEPVLLQSLASLPANNAFLPPSSAASLQPANASLSVKLASLPHKVSRPSFTVHHQPLPRLALAQAAPAAPQASTSGPSAVWVSLGMPPPYAAHLSGVKPR