wanglab/gogpt-training-data huggingface dataset:
Protein: ATP-dependent RNA helicase mtr4 (EC 3.6.4.-) (O14232)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates (By similarity). Required for heterochromatic gene silencing at centromeric repeats by either exosome- or RNAi-mediated degradation of heterochromatic transcripts.
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Protein air1
- Poly
- Poly
- Exosome complex component rrp43
- Exosome complex component csl4
- Exosome complex exonuclease dis3
- Exosome complex component rrp45
- Exosome complex component mtr3
- Exosome complex component rrp46
- Exosome complex component rrp40
Sequence:
MFGGELDDAFGVFEGKVPKSLKEESKNSQNSQNSQKIKRTLTDKNASNQEQGTKKLESSVGEQESATKRAKIENLKDNQDLIPNNDVNGIHINNSAVADTKHKPKIGDIAADDISNEVSIKNEGDTIPEATVADSFEQEASLQVAGKVGMTEAKSSTEEVVELRHQVRHQVSIPPNYDYVPISKHKSPIPPARTYPFTLDPFQAVSIACIERQESVLVSAHTSAGKTVVAEYAVAQSLRDKQRVIYTSPIKALSNQKYRELLAEFGDVGLMTGDVTINPDATCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWEETIILLPDKSHFVFLSATIPNAMQFAEWITKIHRQPCHVVYTDFRPTPLQHYLFPSGSDGIHLVVDEKSNFREENFQRAMSALMEKQGDDPAAMATKGNAKKGKTGKGGVKGPSDIYKIVKMIMVKNYNPVIVFSFSKRECEALALQMSKLDMNDQTERDLVTTIFNNAVNQLSEKDRELPQIEHILPLLRRGIGIHHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTNVRKFDGKTFRWISGGEYIQMSGRAGRRGLDDRGIVILMIDEKMDPPVAKSMLKGEADRLDSAFHLSYNMILNLLRVEGISPEFMLERCFFQFQNSLEVPKLEAKLEESQQHYDSFTILDERPLEEYHTLKTQLERYRTDVRTVVNHPNFCLSFLQGGRLVRVKVGNEDFDWGVVVNVSKRPLPKGQSNEYLPQESYIVHTLVMVASDTGPLRIRSGHLPEVHPPAAEDKGKFEVVPFLLSSLDGIAHIRVFLPNDLKSQGQKLTVGKALSEVKRRFPEGITLLDPVENMNIKEPTFIKLMKKVNILESRLLSNPLHNFSELEEKYAEYLRKLALLEEVKDLKKKLSKARSIMQLDELNSRKRVLRRLGFTTSDDVIEVKGRVACEISSGDGLLLTELIFNGMFNDLTPEQCAALLSCLVFQEKSEVENQRMKEELAGPLKILQEMARRIAKVSKESKQELNEEEYVNSFKPSLMEVVYAWAHGASFAQICKMTDVYEGSLIRMFRRLEELIRQMVDAAKVIGNTSLQQKMEDTIACIHRDIVFSASLYL
Protein: Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1) (Q96MT3)
Organism: Homo sapiens (Human)
Function: Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:14645515}. Cytoplasm, cytosol {ECO:0000269|PubMed:14645515}. Note=A smaller amount is detected in the cytosol.
Interaction partners:
- Vang-like protein 2
- Segment polarity protein dishevelled homolog DVL-1
- Vang-like protein 1
- Segment polarity protein dishevelled homolog DVL-2
- Segment polarity protein dishevelled homolog DVL-3
- Ankyrin repeat domain-containing protein 6
- BTB/POZ domain-containing protein KCTD7
- Cystatin-B
- Cadherin EGF LAG seven-pass G-type receptor 1
- Rho GTPase-activating protein 21
Sequence:
MPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGTSFASEEFWKGRVEQETPEDPEEWADHEDYMTQLLLKFGDKSLFQPQPNEMDIRASEHWISDNMVKSKTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELELDHGASGYNHDETQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGENKPRPSLYSLQNFEEMETEDCEKMSNMGTLNSSMLHRSAESLKSLSSELCPEKILPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGNYDIEIRQPPMSERTRRRVYNFEERGSRSHHHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYAHATSDYGLQNPGMNRFLGLYGEDDDSWCSSSSSSSDSEEEGYFLGQPIPQPRPQRFAYYTDDLSSPPSALPTPQFGQRTTKSKKKKGHKGKNCIIS
Protein: Granzyme-like I (Q58J84)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Interaction partners:
Sequence:
MKALHILLLAAAFISLTFNATHGEEIINGKKAKKNSFQYMASVQSKGKHICGGFLISPSYVLTAAHCFQSNLSVVLGTQNIDAKRNELRRYAVKSMHIHPSYKENPRYGSDIMLLKFSGKVNLNKDLKVIKISSNHKRVKPNTKCQVAGWGKTETQKTVNDLMVTDVSTIDITVCKKQWNKENVELPAKILCAGGYGTKSGACQGDSGGPLVCSGLAVGIVSFNLHDNCSYPNVPNVYTEISAYADWINKVIKRDA
Protein: Tubulin-specific chaperone D (Tubulin folding cofactor D homolog) (Q19493)
Organism: Caenorhabditis elegans
Function: Tubulin-folding protein; involved in the first step of the tubulin folding pathway (By similarity). Plays a role in microtubule polymerization.
Interaction partners:
- ADP-ribosylation factor-like protein 2
- Tubulin-specific chaperone E
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- ATP synthase mitochondrial F1 complex assembly factor 2
- Carbonic anhydrase
- Beta carbonic anhydrase 1
- Hydroxyacid-oxoacid transhydrogenase, mitochondrial
- Tubulin-specific chaperone B
- C-CAP/cofactor C-like domain-containing protein
- Tubulin-specific chaperone A
Sequence:
MDEDAPVDESNEGIIGCLPSAVNIHHIEEIKELVDQLPIIFKLENECDETAAEVNYLRYSRLLHLYQEQPRLLDKWIPEIVANLVDLVTLIGIDVSKPRAMTPLSRESLKYLSDLCIVRGSKTIVRLLPHQVHLLDPLLQTLEYYETSQLSDHNQRNVLLMWLWIVVKNPFDLRRFDPTGDPDNVITRIMNVALHYMKWDWNSSQASAALVIAHCLSRTDGIPKVLSFLSRLLDSIKTHHENKKLLLADLILLLAILKHVDRRVLTGHIGTIHEQLSFLYPIDEKKGGLICKCLVKVVQRIGLIALKPRTCSWSYNRGKRLLEGMLDDNEEYSDEPSFSNKVNSNQSCNNEIDKENQWNDGDELENSEIVEFALMHVLEALSHSDTAVRWSAAKGVGRITVRLPNFDLATQVVGSIISSHFGEVAEYSSWHSHGACLALAELAHRGVLLPSLLEDIVPALELSLVFEDVMGRHQNGNQVRDAACYAVWALSRTYEPSMMAPYLQRLASALLCGALFDRQVNLRRAASAALQEMVGRQKNVSHGIPLIQSVDYFAVTNRQKCYEHLCVPVAEYSTYSAIILRHLITKKVVHWDEKIREQAAISLEKISEIRLENVSDDYYMEILDDFLKASCETRISPFLRHGYLLASGHLIKGLTSRGMDFSSKQTEIAWIPHILWPFCDMTTQPGALIRRTLCKFIQLVSASKKVLLLEKDKSEWLDVLLQLITDPREIIRSLAKTAVGEFVMTYLMNDEELIQKVKTRVIAAMTKCSDESERIGMGMICESLNSEAVDYEMFESLCNTILTPTSSDAKWALARQQTVFALNRISVNSSTETFNRIGQKCFETLYKAMTDYTTSANGDIGRFVREASMRAMSTILVDAKTEPPFLDEHVIKSAKYMVQQSAERISRTRECACACLKSLVKCEITGRCLPHIDLLMNIYSEPMDFISDRTVFQLKPLLDLGSEYYEQLILGIVVSAGGLAEGTQKTAKQLLLDHQREICENKPRFDHFLSTCADLFQRARKVNRIGNSFMQILPQIFGNLGIYEQCPETSESIIEMVDTMKTIAVRSSMMSRQRLSIDSLGELLNCGKKSTVYRSALTMILDTLNSQQPVLRKSAAERLYEHLCCAEESDDEVLEVLATTNWQDENDNVLKQAVAGISEKLIF
Protein: DNA-binding protein (Q7AKQ8)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Interaction partners:
- RNA polymerase sigma factor WhiG
- Regulator
- Probable cell division protein WhiA
- Bifunctional protein PyrR
- Sporulation-specific cell division protein SsgB
- AraC-family transcriptional regulator
- Regulator, BldB
- Aerial mycelium formation
- Regulator
- Transcriptional regulator
Sequence:
MSSEYAKQLGAKLRAIRTQQGLSLHGVEEKSQGRWKAVVVGSYERGDRAVTVQRLAELADFYGVPVQELLPGTTPGGAAEPPPKLVLDLERLATVPAEKAGPLQRYAATIQSQRGDYNGKVLSIRQDDLRTLAVIYDQSPSVLTEQLISWGVLDADARRAVASHDEL
Protein: ABC transporter B family member 23, mitochondrial (ABC transporter ABCB.23) (AtABCB23) (ABC transporter of the mitochondrion 1) (AtATM1) (Iron-sulfur clusters transporter ATM1) (Protein STARIK 2) (Q9FUT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Not involved in the export of cyclic pyranopterin monophosphate (cPMP) from mitochondria into the cytosol.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:17517886, ECO:0000305|PubMed:25732537}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:17517886}.
Interaction partners:
- ABC transporter E family member 1
- ABC transporter E family member 2
- Protein AE7-like 2
- Protein AE7-like 1
- ABC transporter B family member 29, chloroplastic
- ABC transporter B family member 27
- ABC transporter B family member 26, chloroplastic
Sequence:
MMRGSRFLLSRASLYHRLRSDHHHHSFSSFIKRSSIQRSPAINAFFTDPSPSPSPVNARVFFFSTSTSTPNQDQTKTASSKKILRTISSYLWMKDNPELRFRVIAALACLIGAKFLNVQVPFLFKLSIDLLSSYSSSTITDSNPYLLAAFATPSSVLIGYGIARSGSSAFNELRTAVFSKVSLRTIRSVSRKVLSHLHDLDLRYHLNRETGALNRIIDRGSRAINTILSAMVFNVVPTILEISMVTGILAYNFGPVFALITSLSVGSYIAFTLVVTQYRTKFRKAMNQADNDASTRAIDSLVNYETVKYFNNEDYEARKYDDLLGRYEDAALQTQKSLAFLDFGQSFIFSTALSTSMVLCSQGIMNGEMTVGDLVMVNGLLFQLSLPLYFLGGVYRETVQGLVDMKSLFQLLEERSDIGDKDTETKLPPLVLRGGSISFENVHFSYLPERKILDGISFEVPAGKSVAIVGSSGSGKSTILRMIFRFFDTDSGNVRIDGQDIKEVTLESLRSCIGVVPQDTVLFNDTIFHNIHYGNLSATEEEVYDAARRAVIHDTIMKFPDKYSTAVGERGLMLSGGEKQRVALARAFLKSPAILLCDEATNALDSKTEAEIMKTFRSLASNRTCIFIAHRLTTAMQCDEIIVMEKGKVVEKGTHQVLLEKSGRYAKLWTQQNSTLEV
Protein: Ribosomal RNA-processing protein 15 (Q06511)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Constituent of pre-60S ribosomal particles. Required for large subunit rRNA maturation, in particular processing of the 27S pre-rRNA at the A3 and B1 sites to yield 5.8S and 25S rRNA.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ribosome biogenesis protein BRX1
- Ribosome biogenesis protein 15
- Ribosomal RNA-processing protein 1
- Ribosome production factor 1
- Ribosome biogenesis protein SSF1
- Nucleolar protein 16
- ATP-dependent RNA helicase HAS1
- Ribosome biogenesis protein RLP7
- Nucleolar GTP-binding protein 1
- Ribosome biogenesis protein NSA1
Sequence:
MGSKHRVDTKDKKRTRKNAEFGREKRNSGNQELSNEPEKDTIMEGDEAEEDEQNSSSDESSKIIDNEQSDAEEDDDEEEEDDDFPRKKKSKNSKHDDGSTGFSAAVNAILSSHLKAYDRKDPIMARNKKVLKQSESEKLEYKAKKALLAEKKKLLGKARKTDIIPIASGEDRSENIRKVLEKETALRKIAQKGAVKLFNAILATQVKTEKEVSENLSEIKNKEEKKELITEVSKEKFLDLVKAAAGSDNE
Protein: NTF2 domain-containing protein (O18697)
Organism: Caenorhabditis elegans
Interaction partners:
- Cilia- and flagella-associated protein 157
- Protein CASP
- RILP-like protein 1
Sequence:
MSFIAYPCAVPTQRQVPMSPPTTPRILMKLCPIMEIPIIGGPRQNGTYNVFIFDLKIRKFIPHRCSSCAVKILEDHLSPMYASGSVIFMRNEVTQEVEQYVYSFETGGFQQVDYPELVYSAEKFTESSFIVMIENSDGKKVLIERGGNEAVRKLEYRLGKCVEMPKVEVQLLAAEEFDDADPWSDNDSLSSEHLDYNETLPAFKTTFCQDFQMYVLYIITSRGHYEKYIYNQSTSQFEILDCEKCPDTTREVDLLPKYAEFCEEIQAYVIHVFNSFTDRMEQYVFDSKIQGFVEVNQPELKYDSSKDQDPTSSIFFVLKGTTVIMRGAQGRLKKEVYCSIKKHFVEVPNSVIKSFDTQFMEKKQKMDKKKKAKKIKKSKKKASKESQELDVLVEKIRLCDDPFSDGPSCSTSPDIPEDAPDDGMSILKQKFVESLTTLYGGSLPPYVQKELEQI
Protein: Collagen IV NC1 domain-containing protein (Q8BNS7)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
Interaction partners:
Sequence:
GVPGFPGVKGEMGMMGPPGPPGPLGNPGRSGAPGLKGDDGMQGQPGLPGPAGEKGGKGEPGLPGPPGPMHPDFLGSKGEKGEPGLPGIPGLSGPKGYQGLPGDPGQPGLSGQPGSPGLPGPKGNPGLPGPPGLTGPPGPKGNIGDMGFPGPQGVDGPPGPPGFPGQPGSPGLPGQKGSKGEPGVSGIGLPGLPGPKGEPGLPGYPGNPGIKGSVGETGLPGLPGNPGAKGQPGLPGFPGTPGLPGPKGMNGPPGNPGFPGEPGPVGAGGRPGPPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGIPGPPGLPGLSGQKGDGGSPGLPGNPGLPGSKGEPGFQGFPGMPGPPGPPGSPGQALEGPKGNPGPQGPPGRPGPPGTEGPRGPPGNGGIKGERGNPGPPGQPGLPGLKGDQGPPGLPGNPGRPGLNGMKGDPGLPGVPGFPGMKGPIGVPGSTGPDGEPGLTGPPGPPGLPGPSGQSIVIKGDPGPPGIPGQPGLKGLPGLPGPQGLPGPIGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGARGLDGPPGPDGLQGPPGPPGTTSVAHGFLITRHSQTTEAPQCPRGTVHIYEGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLSTPEPMPMNMEPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPHCPQGWDSLWIGYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANSYSFWLATVDMSDMFNKPQSETLKAGDLRTRISRCQVCMKRT
Protein: Endoglucanase 21 (EC 3.2.1.4) (Endo-1,4-beta glucanase 21) (Q9STW8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Endonuclease 1
- Ubiquitin-like superfamily protein
Sequence:
MYGRDPWGGPLEINAADSMTDDDRSRNLQDLDRATPSRPLDETQQSWLLGPKVLKKKKYVDLGCILVSRKIFLWTLGTIVVTALLSGFITLIVKTLPHHHHKEPPPDNYTIALRTALKFFNAQQSGKLPKNIYNVSWRHDSCLQDGKGDPGQCYKDLVGGYYDAGDSIKFNFPMSYAMTMLSWSVIEYSAKYQAAGELEHVKELIKWGTDYFLKTFNSSADNIYVMVEQVGSGVSGRGSELHNDHYCWMRPEDIHYKRTVSQCYSSCSDLAAEMAAALASASIVFKDNRLYSKNLVHGAKTLYRFATTSRNRYSQNGKESSKFYNSSMFEDELLWGGAWLYYATGNVTYLERVTSHHMAEKAGAFGNSPYYGVFSWDNKLPGAQLLLTRMRLFLSPGYPYEDMLSEFHNQTGRVMCSYLPYYKKFNRTNGGLIQLNHGAPQPLQYVANAAFLAALFSDYLEAADTPGWYCGPNFYTTEFLRNFSRSQIDYILGKNPRKMSYVVGYGQRYPKQVHHRGASIPKNMKETCTGGFKWKKSKKNNPNAINGAMVAGPDKHDGFHDIRTNYNYTEPTLAGNAGLVAALVALSGEKAVGGIDKNTMFSAVPPLVMATPPPPAPWTP
Protein: Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) (Q9ES88)
Organism: Mus musculus (Mouse)
Function: Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (By similarity). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (By similarity). Has a critical role in renal dicarboxylate transport.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q13183}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MATCWQALWAYRSYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLEYFKDTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLQGSQKDVEEGNSNPSFELQEASPQKEETKLDNGQAVSVSSEPRAQKTKEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFPENSNVVNFASWFGFAFPTMVILLLLAWLWLQVLFLGVNFRKNFGFGEGEEERKQAAFQVIKTQHRLLGPMSFAEKAVTFLFVLLVVLWFTREPGFFPGWGDTAFANKKGQSMVSDGTVAIFISLIMFIIPSKIPGLTEDPKKPGKLKAPPAILTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTPLQHVPPSATVLILSLLVAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSWSIPIFKLDTFPTWAYSNTSQCLLNPPNSTVPGH
Protein: Rapamycin-insensitive companion of TOR2 (Q57YZ3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Serine/threonine-protein kinase TOR
- Serine/threonine-protein kinase TOR
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- PI3K/PI4K catalytic domain-containing protein
- non-specific serine/threonine protein kinase
- Rac serine-threonine kinase, putative
- Raptor N-terminal CASPase-like domain-containing protein
- Raptor N-terminal CASPase-like domain-containing protein
Sequence:
MVTTGLSPGALSLLQNAGINLKDFSRAQASYEKLCVELSKGASAAGEGDATAASSMEDLQRLCDAWGEYTVVAQAYFRKVSLAALEQLVSRPRGESSATERAEKLNELCAIGEKWHVGRETMFKLDHPEKLAAVVVEALDSSSCIMRLLALRLARIFAADTEFLRCLFSKGGAGLIGMCFDHENTTELEYVLSLCRRLIELHKASAEPYHELPFGWVYRIAALLDLQDPVPNLLLKRRSQALCVAVMLLRQFPQMATTASLHITLLRYCIEKGAATRDEVQSVLEVILDMFDSPETRQYLGYNDLDVLYAPFLYSTNMCSTEDLTLMNGAKEVLVMLMRNWVGVLWVCSETKGLRAVIDILHLPCDLDRKMVLLTLFNKLLYQLAPHRGITLVEPWRGFKEKQELFPATPNEPADSEGSFVLNTPLGRGHNSSESMISEHVFGDWCDEPDEFVPTTKAIGYHVLDPILGRVLLMLSHHGLPIALVSVIQDPNSSSVLTHAALSLLQDMLTLMDTVLPEKPVKRLHTALNKAVGRLALEGCLSLEGVLSSRIPQRGKTAKGIATTATVAVGNVVGSGWVSALSTASVATYGLGALEQDDADFKRMLKDTNVEGGNSFLSWNYDLLLLLFQGPLKSIRRFRWVLNETLFFRNLIAFYLPVINTSTRTFLTLQPREATPQVCMLGMVMLDLFLSTREGTAALDSFGFSGAMAACLEEVIRGTPYVLNKQRVGKRVGQTLLRMVGRYSMTANGLVVLKDSNMFSTINRMFVELSGERVSAPYPDDTLQEVCLQLLRCMNLGAVPNYGVCEWIRQMFRSALCNESDEIRLCAVKQLRDALWRDFSTSMRWGIETLVQALHDDHSRVVECAFKLLLNVCFCSDEALDYLISLSPTVLMESDTIRENAKQLDLNTLLYCIVGRPSGFRFLQCYGWVEQELRRWEETESANHVTTVENMQSGRALGSGADFREGMSALFRHRHNRTYSDTGLTFQKPITATAGPDSQVTLPSGIFPSHFAAVLCKSNEGCTLFKHSNLWQRSVRRILEQPMLPDIVYECGTFGERDNIDDDDVDMDGTTADDDDANALIEEDPSFVGRWGTEAAKTSTAKQDEKHALRLSREGHLPSSHSVKLLSASRGYQAAGQTYTIECVGDVSELKDAILCVCHAASSDAGFSLMRSVPMLQNQLMALSRFADTASVSSICIVGKCLLARSRRAAEKLTEISHYVVNESNAYMSADGVPYSVAFADNRPSNWTAIGRRDNPSRVSCSPPYFAHMRYDGEMVDGNSKNDEETTDSVGSTPSPVDSRDSSTFCDVIKGLSATSTRILHHIFALSNPVRRDAARQMLSQTLKHQPHIFVNPQMRWLLRHCAQAFRMRYDDRKFIASILEEAPLTKPTPLVRKTVVFVPEPQRG
Protein: MADS-box transcription factor 8 (MADS-box protein 24) (OsMADS24) (OsMADS8) (Q9SAR1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor. May be involved in the control of flowering time.
Subcellular location: Nucleus {ECO:0000269|PubMed:19561057}.
Interaction partners:
- MADS-box transcription factor 6
Sequence:
MGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSGQSMTRTLERYQKFSYGGPDTAIQNKENELVQSSRNEYLKLKARVENLQRTQRNLLGEDLGTLGIKELEQLEKQLDSSLRHIRSTRTQHMLDQLTDLQRREQMLCEANKCLRRKLEESNQLHGQVWEHGATLLGYERQSPHAVQQVPPHGGNGFFHSLEAAAEPTLQIGFTPEQMNNSCVTAFMPTWLP
Protein: Bacilliredoxin BrxB (Brx-B) (Bacilliredoxin YqiW) (Dithiol bacilliredoxin) (P54534)
Organism: Bacillus subtilis (strain 168)
Function: S-bacillithiolation is the formation of mixed disulfide bonds between protein thiols and the general thiol reductant bacillithiol (BSH) under oxidative stress. BSH is an equivalent of glutathione (GSH) in Firmicutes. This protein is a dithiol bacilliredoxin, which debacillithiolates (removes BSH) the S-bacillithiolated OhrR (OhrR-SSB) in vitro and in vivo NaOCl-generated S-bacillithiolated MetE (MetE-SSB). Involved in maintaining redox homeostasis in response to disulfide stress conditions.
Interaction partners:
- Bacilliredoxin reductase Bdr
- Monothiol bacilliredoxin BrxC
- Putative cysteine ligase BshC
- N-acetyl-alpha-D-glucosaminyl L-malate synthase
- Organic hydroperoxide resistance transcriptional regulator
- Putative metal-dependent hydrolase YfiT
- Probable N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 2
- N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1
Sequence:
MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTTLVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSSPSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV
Protein: Elongation factor G-1, mitochondrial (EF-Gmt) (mEF-G 1-1) (Elongation factor G1-1) (Q9C641)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03061, ECO:0000269|PubMed:14671022}.
Interaction partners:
- Diphthine--ammonia ligase
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Protein STABILIZED1
- At4g01000
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- Large ribosomal subunit protein bL28c
- Large ribosomal subunit protein uL10c
- Large ribosomal subunit protein bL31c
- At1g43860
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MARFPTSPAPNRLLRLFSSNKRSSSPTAALLTGDFQLIRHFSAGTAARVAKDEKEPWWKESMDKLRNIGISAHIDSGKTTLTERVLFYTGRIHEIHEVRGRDGVGAKMDSMDLEREKGITIQSAATYCTWKDYKVNIIDTPGHVDFTIEVERALRVLDGAILVLCSVGGVQSQSITVDRQMRRYEVPRVAFINKLDRMGADPWKVLNQARAKLRHHSAAVQVPIGLEENFQGLIDLIHVKAYFFHGSSGENVVAGDIPADMEGLVAEKRRELIETVSEVDDVLAEKFLNDEPVSASELEEAIRRATIAQTFVPVFMGSAFKNKGVQPLLDGVVSFLPSPNEVNNYALDQNNNEERVTLTGSPDGPLVALAFKLEEGRFGQLTYLRVYEGVIKKGDFIINVNTGKRIKVPRLVRMHSNDMEDIQEAHAGQIVAVFGIECASGDTFTDGSVKYTMTSMNVPEPVMSLAVQPVSKDSGGQFSKALNRFQKEDPTFRVGLDPESGQTIISGMGELHLDIYVERMRREYKVDATVGKPRVNFRETITQRAEFDYLHKKQSGGAGQYGRVTGYVEPLPPGSKEKFEFENMIVGQAIPSGFIPAIEKGFKEAANSGSLIGHPVENLRIVLTDGASHAVDSSELAFKMAAIYAFRLCYTAARPVILEPVMLVELKVPTEFQGTVAGDINKRKGIIVGNDQEGDDSVITANVPLNNMFGYSTSLRSMTQGKGEFTMEYKEHSAVSNEVQAQLVNAYSASKATE
Protein: Pentatricopeptide repeat-containing protein OGR1, mitochondrial (Protein OPAQUE AND GROWTH RETARDATION 1) (B8YEK4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in multiple sites RNA editing events in mitochondria. Essential for C-to-U RNA editing at seven specific sites of nad2, nad4, cox2, cox3 and ccmC transcripts, all coding for proteins involved in the mitochondrial electron transport chain coupled to ATP generation. Required for normal growth and development.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19453459}.
Interaction partners:
Sequence:
MSVSAAARHLESLLPRLASLRHYLQFHARLLTSGHLGAHPGLRARFLDRLALSPHPAALPHALLLLRSLPTPATNDLNAALRGLAASPHPARSLLLLAGRLLPALLPRPDALSLSFALKASARCSDAHTTVQLHALVLRLGVAADVRLLTTLLDSYAKCGDLASARKVFDEMTVRDVATWNSLLAGLAQGTEPNLALALFHRLANSFQELPSREEPNEVTIVAALSACAQIGLLKDGMYVHEFAKRFGLDRNVRVCNSLIDMYSKCGSLSRALDVFHSIKPEDQTLVSYNAAIQAHSMHGHGGDALRLFDEMPTRIEPDGVTYLAVLCGCNHSGLVDDGLRVFNSMRVAPNMKHYGTIVDLLGRAGRLTEAYDTVISMPFPADIVLWQTLLGAAKMHGVVELAELAANKLAELGSNVDGDYVLLSNVYASKARWMDVGRVRDTMRSNDVRKVPGFSYTEIDGVMHKFINGDKEHPRWQEIYRALEDIVSRISELGYEPETSNVLHDIGEEEKQYALCYHSEKLAIAFGLIATPPGETLRVIKNLRICGDCHVVAKLISKAYGRVIVIRDRARFHRFEDGQCSCRDYW
Protein: Tektin-3 (Q6X6Z7)
Organism: Mus musculus (Mouse)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Required for normal sperm mobility.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A6H782}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q4V8G8}. Note=In spermatozoa, preferentially localizes to the flagella, but also found in the head (By similarity). In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (By similarity). Not detected in the central axonemal region of the flagellum (By similarity). Associates with the acrosome membrane in the equatorial segment of the sperm head (By similarity). Also detected just below the plasma membrane in the post-acrosomal region where it might localize to the postacrosomal dense lamina (By similarity). However, other studies report little or no expression in the postacrosomal region (By similarity). Translocates from the postacrosomal region to the equatorial segment after sperm activation (By similarity). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (By similarity). Some studies report strong expression in the anterior cap region (By similarity). However, other studies report little or no expression in the acrosomal cap (By similarity). {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8, ECO:0000250|UniProtKB:Q9BXF9}.
Interaction partners:
- Sperm-associated antigen 8
- RIB43A-like with coiled-coils protein 2
- Tektin-2
- EF-hand domain-containing protein 1
- Piercer of microtubule wall 1 protein
- EF-hand domain-containing family member C2
- EF-hand domain-containing family member B
- Tektin-1
- Tektin-4
- Cilia- and flagella-associated protein 52
Sequence:
MELLGSTLTATYAHPPPASASFLPAIGTITSSYKDRFPHRNLTHSLSLPWRPNTYYKTAYNYPTLAPYSSRSQRVCESTMLPFVSNRTTFFTRYTPDDWYRSNLVSFQESNSSRHNSERLRVDTSRLIQDKYQQIRKTQAHSTQNLGERVNDLAFWKSEITHELDEMIGETNALTDIKRRLERGLIETEGPLQVSRECLFHREKRMGIDLVHDEAEKELLAEVDTILCCQERMRQHLDKANAQLASDRSAQHELEKDLSDKQAALRIDDKCQHLRNTSEGVSYFRGVERVDATVSVPETWAKFTDDNVLRSQSERAASAKLREETENLLIVTANEMWNQFNKVNLAFTNRIAETVDAKNKIHTHLTKTLQEIFQIEMTIESIKKAIKEKSAFLKVAQTRLDERTRRPNVELCRDMAQLRLVNEVYEVDETIQTLQQRLRDSEDTLQSLAHTKATLEHDLAVKANTLYIDQEKCMSMRNSYPSTLRLVGYC
Protein: V-type proton ATPase subunit H (B3KUZ7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRSPEEKQEMLQTEGSQCAKTFINLMTHICKEQTVQYILTMVDDMLQENHQRVSIFFDYARCSKNTAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTVSSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIRFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAAARS