wanglab/gogpt-training-data huggingface dataset:
Protein: Protein commissureless 1 (Protein commissureless) (Q24139)
Organism: Drosophila melanogaster (Fruit fly)
Function: Controls axon guidance across the CNS midline by preventing the delivery of Robo to the growth cone.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Roundabout 1, isoform A
- E3 ubiquitin-protein ligase Nedd-4
- Roundabout 2, isoform B
- LP22668p
Sequence:
MISTTDYPTVETTTTAEELYAEYISAPASSMSPAAIAEHLQQNQITFEIPSAHDLRHIDALNSFNALLQRIGNAAVSYDPAPPSGWSPDGSISTEQLSKSVVLDLADLRDRSEESGESSWWSQIFGDADMHVIINYLWIGVVSSLVILSLVFILFSCYFYRKFRTWKKCNKDIRAQIHAASDSYSSHLVGCDASRLLLHQQMQHPHHRSSEAGFYQIESPPCYTIATGLPSYDEALHHQPRHFAYGMKFVYPSLAAVHHHHHCISNWEKQEPLNKLQKCKLSAAAAVEEDKADSSSSTSASASPSSSESSNLATATPAICINMPSGRQDEEVDNSDSDSAIAVAVAVAQSLQPAAPADDDCASLVVVVAA
Protein: M6, isoform G (M6-D isoform) (H9A9K2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGECCQSCMARIPYATLIATLMCLLGVGIFCFTMYRGASLTVIMVDQVFHLRLIWIEAVQMIFVIIGAGMAALGFMILFVGFLATGATRYKVYRAWRSRVGGRISCAVLMGITYLLNFVWSLILCFLVVVTFIYTMFWNMCTSVEHSQSCIDLTQFRKPLNIHKDKPSNTTSIPQILCSRQTRNWRT
Protein: Protein TOPAZ1 (Testis- and ovary-specific PAZ domain-containing protein 1) (E5FYH1)
Organism: Mus musculus (Mouse)
Function: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22069478}.
Interaction partners:
Sequence:
MRPPATPPDPTKEPGCKGTTRGLRKRGLPLTPEPGEGGGCSLEARGCEEESRQKQRMVTQASGREETEGDKLAKENGKITEAPSDDPQPGTDLVRKTSITSSESLQTVECSEFQNMAFLQSLDKEELGEGIKRRMRIKKCKSLENPPLEITKNEATQNIKVEFQDELFKNTPKHSCNSLSPGVEKNCSFELHDYSFLHSEGCNNENNFEDKPHDVCLHTEENSLKLKKENLRNLAEKDDTRTTTKLLKTEKSVIASKLLLEESHLYQNKNNGLTSCLQSEKNKYSVEENNTGRKHRKKMKSGKEEKNINLTLSNVCNNSVLVLQENQMGMEGKEAETLEPKKSFLKALRKINHNTLPPVDHLCLPKTVGKTSSRHHINAMLQKTLESSLKEDIKNTSESLGCKRIEPEKYNKSMISSTVKSPSDGHHMEKRSPRGDLRSETEESKVSCCRTIPMTGKRVWPFYSCARISAQCWKKTSLSDLNYSLLGPLENVRQHDSIIHQMNQTHLPDSKLLQPSLTERTTESSRKEMYDSDLSCLSSVSSVESTVMDIKEAMSHDKKTKLEEPSRNGAEVVSNATEDTQLSNITQSLTGNKKRKGNLSKLNLTVASQESQETNNCANKTVHRKVCITKQTLVAPDLVKILNTGRLTNFKIPLLKNKTGKRGAVSARSSEREAYSPLELLDSLSGVEAKQNRNKENICTTSGPQSLNLHSCIAPGQASSHSFYNKNSCTSSSFTKKGYDNKACNHISEPGNIISNKESISMKIENNTFSCDLGYIDQSSFCSKKQEAFVPISSEISGRKMTKSISELKLGFPDILKAYEDDVLLIDVIQDDPELFGISSEGDLSFASEVSKISQEPRVSEDQPTADFKHMHLPGKKEPGDLSKEVALLDPGLLKLESCPSLSAAKEPQHDPEGAAISLEATEETVVSGSLEGLSEQARASDSDAKCISSDKATVMEEQESTHEIFKSKDSRNVESATECQLATLGPNPLCSSALPVNLSSHQDVVSTPWINDVRFPGRHSVLQLQNPETCEIFKREKNMGVFQKPLGLLIPHRYCKLHFNTLRGCERAQCKFVHVPEQGDEKICMDVFRKYISVNEQRLLHRAAYIFLEYYRKFPPGIHFSLQVLNDLLISLLKHCLLKEVFQVVQLSIMAKMLPALKILLKIFEYVAAMKLRNAVPALIEIFCKFIEAGMVPDPEHLNYIVKLLHQAQASQQEISAVLQAKSRLRVRQLKKNWKCDLDSALSEVETCKEKSDWTKLGNLYISIKMSCEEFADLQRFCACVAETLTEDYKEERPGVPFCEFAETVSKDPQYSEVDKTLLGRIGISAVYFYHRLLLWAKGRKVLDILYELKIHFTSLKGLTGPEKEAPRCQIVNVAAEIFIKSGSLDGAIWVLRESEWIINTPLWPCDRMDVLNRHNLLCTIAHEILGKNLYKQTFEVLRNLPSFQNSQEMMGVSQSSLLFNELLDACIESNSLGISSSVAEFMVAKSIPIDFSFLRRLITSLGRSCLWLKARAHYKSALSLGCYPPLEGNLHRKLLLVPSYLSEIEMLLAMEIFLVSNASGIQSAGMGAPTQVLQIVLKRCEESKSRSKDEYQAAVERLVMAARISDPKLFIKHMTVNINKEQVYSLEHCSALKWLKENMKWAGKVWLFTNH
Protein: Serine/threonine-protein kinase BSK4 (EC 2.7.11.1) (Brassinosteroid-signaling kinase 4) (F4HU55)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Functions redundantly with BSK3, BSK6, BSK7 and BSK8.
Subcellular location: Cell membrane {ECO:0000305|PubMed:12912986}; Lipid-anchor {ECO:0000305|PubMed:12912986}.
Interaction partners:
- Serine/threonine-protein phosphatase BSU1
- Protein BRASSINOSTEROID INSENSITIVE 1
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Shaggy-related protein kinase eta
- Shaggy-related protein kinase iota
- Protein BRASSINAZOLE-RESISTANT 1
- Putative acyl-activating enzyme 19
Sequence:
MGGQSSKIGTCCSHKTTALEAPDVENKENGEVNGVHSFREYSLEQLKIATSCFALENVVSEHGETAPNVVYQGKLENHMKIAIKRFSGTAWPDPRQFLEEARLVGQLRSKRMANLLGYCCEGGERLLVAEFMPNETLAKHLFHWDTEPMKWAMRLRVALYISEALEYCSNNGHTLYHDLNAYRVLFDEECNPRLSTFGLMKNSRDGKSYSTNLAFTPPEYLRTGRITAESVIYSFGTLLLDLLTGKHIPPSHALDLIRDRNLQTLTDSCLEGQFSDSDGTELVRLTSCCLQYEARERPNIKSLVTALISLQKDTEVLSHVLMGLPQSGTFASPPSPFAEACSGKDLTSMVEILEKIGYKDDEDLSFMWTEQMQEAINSKKKGDIAFRRKDFSEAIEFYTQFLDLGMISATVLVRRSQSYLMSNMAKEALDDAMKAQGISPVWYVALYLQSAALSVLGMEKESQIALTEGSILEARKISASTQN
Protein: Myosin-4 (MYOSIN VIII B) (AtVIIIB) (F4JIU4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables (By similarity).
Interaction partners:
- F-box/LRR protein
- Membrane lipoprotein lipid attachment site-like protein, putative
- AT4g27380/M4I22_190
- AT4g20040/F18F4_140
- AT4g27390/M4I22_200
- Non-canonical heme oxygenase HOZ, chloroplastic
- Transcription factor IND
- Dynein light chain
- UDP-N-acetylglucosamine transferase subunit ALG14
Sequence:
MMKSSVKEILESLRLLDSSERSSSLPSPSTFRAPMPLIRQSLPAKFRNAISLESKTIEKEDKDWSTEQITQSAEKEKTGNEVVKISTAQMSRAKNSHDPEWINSAEYFVREKLCVWCRVAANGQWHLGKIHSTSSSDDVCVMLSANDDVRTMEEIFPANPEILEGVEDLTQLSYLNEPSLLYNLRVRYSQDLIYSKAGPVLIAVNPFKNVQIYGEEFLSAYQKNALDAPHVYAVADAAYDDMMREEKNQSIIISGESGAGKTETAKYAMQYLEALGGGSFGVENEILKTNCILEAFGNAKTSRNDNSSRFGKLMEIHFSAKGKICGAKLETFSLDQSRVAQLCNGERCYHIFYQLCAGASPILKERLKIKAASEYNYLNQSNCLTIDRTDDAQKFHKLMEAFNIVQIPQEYQERTFALLAAVLWLGNVSFEVIDNENHVEVVADEAVTNVAMLMGCNSKKLMVVLSTCKLQAGRDCIAKRLTLRQATDMRDSLAKIIYASLFNWLVEQINISLEVGNSRTGRSISILDIYGFESFKDNSFEQFCINYANERLQQHFNRHLFKLEQEEYEGDGIDWTKVEFIDNQECLNLIEKKPIGLVSLLNEESNFPKATDTTFANKLKQHLNANSCFKGERGRGFRIKHYAGEVLYNTNGFLEKNRDPLHVDLIQLLSLCKCQLLNLFSTKMHHDFLKPATFSDSMNQSVIAKFKGQLFKLMNKLEDTTPHFIRCIKPNSNQLPGLYEENHVLQQLRCCGVLEIVRISRSGYPTRLTHQELAVRYGCLLLDTRISQDPLSTSKAILKQCNLPPEMYQVGYTKIYLRTGVISVLEERKKYVLRGILGLQKQFRGYQTREYFHNMRNAAVILQSYIRGENARRNYIVVGESAIVSTAITKELDAAIHLQYMVRKWLARKLLNSTQQKNKPRNEKKKTRRKSTKRVSEDKELLSEQFEVQPCVLADLQSRVLKVEAAIMQKEDENTALQEELQRFEERWLENETRMKSMEDTWQKHMSSMQMSLAAACKVLAPDKTASHGTDSEDTMSFGTPTKELKGSLSDVNNLSTEFDQRSVIIHEDPKSLVEVKSDSISNRKQHAEELRRLKSRFEKWKKDYKTRLRETKARVRLNGDEGRHRNWWCKKSY
Protein: Acetyl-CoA carboxylase, isoform E (EC 6.4.1.2) (A8DY67)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLKRRASKRFVLVESGEDNANGSGSASGSGSGSGVGTAVIPQFVAVDCGQNESNNNHVGEMSASISNHNSSNNQSSPSLLSVPVVGTLKPSMSRGTGLGQDRHQDRDFHIATTEEFVKRFGGTRVINKVLIANNGIAAVKCMRSIRRWAYEMFKNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGSNNNNYANVELIVDIALRTQVQAVWAGWGHASENPKLPELLHKEGLVFLGPPERAMWALGDKVASSIVAQTAEIPTLPWSGSDLKAQYSGKKIKISSELFARGCVTNVEQGLAAVNKIGFPVMIKASEGGGGKGIRRVDTTEEFPGLFRQVQAEVPGSPIFVMKLARGARHLEVQLLADQYGNAISLFGRDCSIQRRHQKIIEEAPAIVAQPEVFEDMEKAAVRLAKMVGYVSAGTVEYLYDPEGRYFFLELNPRLQVEHPCTEMVADVNLPAAQLQIGMGIPLYRLKDIRLLYGESPWGSSVIDFENPPNKPRPSGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAASGGLHEFADSQFGHCFSWGENRQQARENLVIALKELSIRGDFRTTVEYLITLLETNRFLDNSIDTAWLDALIAERVQSEKPDILLGVMCGSLHIADRQITESFSSFQTSLEKGQIQAANTLTNVVDVELINDGIRYKVQAAKSGANSYFLLMNSSFKEIEVHRLSDGGLLISLEGASYTTYMKEEVDRYRIVIGNQTCVFEKENDPSLLRSPSAGKLINMIVEDGAHVSKGQAYAEIEVMKMVMTLTSQEAGTVTFVRRPGAVLDAGSLLGHLELDDPSLVTKAQPFKGQFLQPENAPVPEKLNRVHNTYKSILENTLAGYCLPEPFNAQRLRDIIEKFMQSLRDPSLPLLELQEVIASISGRIPISVEKKIRKLMTLYERNITSVLAQFPSQQIASVIDSHAATLQKRADRDVFFLTTQSIVQLVQRYRNGIRGRMKAAVHELLRQYYDVESQFQYGHYDKCVGLVREHNKDDMQTVVNTIFSHSQVAKKNLLVTLLIDHLWANEPGLTDELANTLSELTSLNRAEHSRVALRSRQVLIAAHQPAYELRHNQMESIFLSAVDMYGHDFHPENLQRLILSETSIFDILHDFFYHSNRAVCNAALEVYVRRAYTSYELTCLQHLELSGGLPLVHFQFLLPTAHPNRLFSRMSSPDGLDQAAAESLGNSFVRTGAIAAFDSFEHFEMYSDEILDLLEDFVSPAMVNAKVLEAVEAADSISDSRHSTSINVSLSDPVTRANAAEEAKSTEPIHIVSVAVRETGELDDLQMAQIFGNYCQEHNEELFQRRIRRITFAALKKRQFPKFFTFRARDKFTEDRIYRHLEPASAFHLELNRMKTYDLEALPTANQKMHLYLGKAKVSKGQEVTDYRFFIRSIIRHSDLITKEASFEYLQNEGERVLLEAMDELEVAFSHPHAKRTDCNHIFLNFVPTVIMDPAKIEESVTKMIMRYGPRLWKLRVLQAELKMVIRQSPQSPTQAVRLCIANDSGYFLDISMYTEQTEPETGIIKFKAYGEKQGSLHGHPISTPYMTKDFLQQKRFQAQSNGTTYVYDVPDMFRQMTERHWREFSKARPTVDIRTPDKILIECKELVLEGDNLVEMQRLPGENNCGMVAWRIVLATPEYPNGREIIVIANDLTYLIGSFGIKEDVLFAKASQLARQLKVPRIYISVNSGARIGLAEEVKAMFKIAWEDPEEPDKGFKYLYLSTEDYAQVANLNSVRAILIEDEGEQRYKITDIIGKDDGLGVENLRYAGLIAGETSQAYEEIVTIAMVTCRTIGIGSYVVRLGQRVIQIDNSHIILTGYAALNKLLGRKVYASNNQLGGTQIMFNNGVTHKTEAIDLDGVYTILDWLSYIPAYIGCDLPIVLPNDRIERPVDFMPTKSPYDPRWMLGGRVNPVNANDWENGFFDRDSWSEIMASWAKTVVTGRARLGGVPVGVIAVETRTVEVEMPADPANLDSEAKTLQQAGQVWYPDSSYKTAQAIKDFGREELPLIVFANWRGFSGGMKDMYEQIVKFGAYIVDGLREYKKPVLIYLPPNAELRGGAWAVLDSLINPRYMETYADPEARGGVLEPEGIVEIKYKEKDLVKTIHRLDPTTIALKKELDEANASGDKVRAAQVDEKIKARIAVLMHVYHTVAVHFADLHDTPERMLEKECISEIVPWRDSRRWLYWRLRRLLLEDAYIKKILRAQDNLSVGQAKQMLRRWLVEEKGATEAYLWDKNEEMVSWYEEQINAESIVSRNVNSVRRDAIISTISKMLEDCPDVALDAVVGLCQGLTPVNRGVVVRTLAQMQLNEETSNSNQG
Protein: CUB1 family protein C30C2.08 (Q9P6K3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in bleomycin tolerance with links to DNA repair and/or proteasome function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Eukaryotic translation initiation factor 4 gamma
- Polyadenylate-binding protein, cytoplasmic and nuclear
Sequence:
MMSYEPAEPVPVEEQPILEKLIGIRQRLAVLKRDRTRFIEKNEVFHLKDELVEQMNLLDSRRSTNSTRTIVDSQLEDCLHLLSLFYLAIGRNNDLPAFFVQLGTVRRLLEYNLEGACYTQNDLKPLKERLERIRAAIVEGSKKEDASPVVVKYLNNKLAVCDRNYSEAQHNISKISPELIGIQTRLVSIHRQIDGFAVRPTSDPGFIDRTMEQLKEIEEMKDSNGMFCDADHVPLQGQELCNGILEECFSFLEDAKTKEGLSDEMKSSPKLQQIYHRLDELLNKLKHLTLTHRWTLRETDLYVYRASLAEIDSMRIDGQFLDEQGNAPAGQRILLYLLRRCYAYIYQLLSSSEPVSEELMAVHNQLRTVKRCLLEVQRSGGICSERDLYPYQMKLASLENLRVNGKFLASDHSVPEGQELVNSLLTQCHQLIEELRDEKHQHDIEEREGSENTDGNL
Protein: Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) (Q9WVS8)
Organism: Mus musculus (Mouse)
Function: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11139578}. Nucleus {ECO:0000269|PubMed:11139578}. Nucleus, PML body {ECO:0000250}. Note=Translocates to the nucleus upon activation. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Isoform 1 is detected in cytoplasm and nucleus. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000250}. Note=Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000250}. Note=Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation (By similarity). {ECO:0000250}.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase 5
- Ribosomal protein S6 kinase alpha-3
- Nuclear factor erythroid 2-related factor 2
- Ribosomal protein S6 kinase alpha-1
- Ribosomal protein S6 kinase alpha-2
- Rap guanine nucleotide exchange factor 3
- Ribosomal protein S6 kinase alpha-6
- Nuclear receptor subfamily 4 group A member 1
- Gap junction alpha-1 protein
- Protein kinase C zeta type
Sequence:
MAEPLKEEDGEDGSGEPPGRVKAEPVHTAASVVAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPVCPDVEMPSPWAPSGDCAMESPPPALPPCSDPAPDTVDLTLQPAPPASELAPPKREGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMARPPAPAPAPAPAPAPAPSSAQPTSTPTGPVSQSTGPLQPAGSIPGPASQPVCPPPGPVPQPAGPIPAPLQTAPSTSLLASQSLVPPSGLPGSGAPEVLPYFPSGPPPPDPGLTPQPSTSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLSDLPDLQEP
Protein: Inorganic triphosphatase (PPPase) (EC 3.6.1.25) (Adenosinetriphosphatase) (ATPase) (Polyphosphatase) (A3DIJ8)
Organism: Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)
Function: Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes vigorously the hydrolysis of inorganic triphosphate (PPPi), however it can also catalyze the hydrolysis of ATP to ADP and phosphate. It can use ribonucleotides such as GTP, CTP, or UTP and deoxynucleotides such as dATP, dGTP, dCTP, and dTTP.
Interaction partners:
- Nucleoside diphosphate kinase
- GTP diphosphokinase
- Anaerobic ribonucleoside-triphosphate reductase
- Riboflavin biosynthesis protein RibBA
- GTP cyclohydrolase 1
Sequence:
MGKEIEKKFIVSGDAYKSLAKGVLYRQGYIFFDKDKSVRVRVFNDKGYLTVKGTSTGISRLEYEYEIPVGEANEILEYLCEKPVIEKLRYKFQFEGFTWEVDEFLGENEGLVIAEIELPDENAVFKKPDWIGREVTGDPRYLNSNLVKNPYKNFKE
Protein: Sphingosine-1-phosphate transporter MFSD2B (Major facilitator superfamily domain-containing protein 2B) (mMfsd2b) (Q3T9M1)
Organism: Mus musculus (Mouse)
Function: Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology. Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation. Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate). Release of sphingosine-1-phosphate is facilitated by a proton gradient. In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport. In addition to export, also able to mediate S1P import. Does not transport lysophosphatidylcholine (LPC).
Subcellular location: Cell membrane {ECO:0000269|PubMed:29045386, ECO:0000269|PubMed:29563527, ECO:0000269|PubMed:33863882}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the cell membrane and intracellular membranes. {ECO:0000269|PubMed:29045386}.
Interaction partners:
- Sphingosine-1-phosphate transporter SPNS2
Sequence:
MSVPHGPTPAPVAEPHTQEPGSDKRDGRLSVCTKVCYGIGGVPNQVASSASAFYLQLFLLDVAQIPAAQVSLALFGGKVSGAVADPVAGFFINKSRRTGSGRLMPWALGCMPLIALAYFFLWFLPPFTSLRGLWYTSFYCLFQALATFFQVPYTALTMILTPSPRERDSATAYRMTMEMAGTLMGATVHGLIVSSAHGSQRCEDTVHPRSPAVSPDVARLYCIAAAVVALTYPVCGSLLCLGVKEQPDTSAPASGQGLNFFTGLAITSQHPPYLSLVVSFLFISAAVQVEQSYLVLFCTHASKLQDHVQNLVLIILVSAVLSTPLWEWVLQRFGKKTSAFGICVMVPFSILLAAVPSAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHRCGPGVETIFYSSYVFFTKLSGAGALGISTLSLEFAGCEAGACQQAEEVVVTLKVLIGAVPTCMILIGLCILLVGPTPKMPRQDTSSQLSLRRRTSYSLA
Protein: Matrix protein (S5TDC0)
Organism: Vesicular stomatitis New Jersey virus
Subcellular location: Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus membrane {ECO:0000256|ARBA:ARBA00037802}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037802}. Virion {ECO:0000256|ARBA:ARBA00004328}.
Interaction partners:
Sequence:
MSSFKKILGLSSKSHKKSKKLGLPPPYDESSPMEIQPSAPLSNDFFGMEDMDLYDKDSLRYEKFRFMLKMTVRSNKPFRSYDDVTAAVSQWDNSYIGMVGKRPFYKIIALIGSSHLQATPAVLADLNQPEYYATLTGRCFLPHRLGLIPPMFNVSETFRKPFNIGIYKGTLDFTFTVSDDESNEKVPHIWEYMNPKYQSQIQKEGLKFGLILSKKATGTWVLDQLSPFK
Protein: Free fatty acid receptor 2 (G-protein coupled receptor 43) (Q76EI6)
Organism: Rattus norvegicus (Rat)
Function: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Peptide YY
- G-protein coupled bile acid receptor 1
- Pro-neuropeptide Y
- Appetite-regulating hormone
- G protein-coupled receptor 84
- Free fatty acid receptor 4
- Olfactory receptor 51E2
- Glucose-dependent insulinotropic receptor
- Olfactory receptor
- Pro-glucagon
Sequence:
MTPDWHSSLILTAYILIFLTGLPANLLALRAFVSRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQAQLDVVLPVRLELCLVLFFVPMTVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFHLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLLRNPGSSMLGRGAEETVEGTKTDRGGSQTEGAQSSDFVTE
Protein: Cation/calcium exchanger 2 (Protein CATION EXCHANGER 8) (Q9FKP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Membrane-localized H(+)-dependent K(+) and Na(+) transporter.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Vacuolar cation/proton exchanger 2
- Vacuolar cation/proton exchanger 5
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- At5g19500
- Chloroplastic calcium uniporter protein
- Magnesium/proton exchanger
- ADP,ATP carrier protein
- Sodium/calcium exchanger NCL
- Putative vacuolar cation/proton exchanger 6
- Putative DNA repair protein recA homolog 4
Sequence:
MGFSFSSNRFGYLTVTFLLVISCLLLGFFTNPVDSSALRPKSEHDCSALKHFHDYKSKCAYLKSIDPCASQGFFDYLSFLYCNFEGFPILGQFLLFLWLLLLFYLLGHTASEYFCSSLESLSKLLNLSPTVAGVTLLSLGNGAPDLFASLVSFMGESKGTYDVGLNTVVGGSGFVTCVVVGIISISLHKRRVRIERAAFIRDICFFCAAIGSLALILVYGKINFWGALGFCSLYAVYVAFVVLSWRFGGDQGAESDLESIHKRGSLSEPILQRDGLEEIEDGVVNGEHQIVDDDDDHQRYYYWKRLVIWAITLPLNLPRILTIPVVSEDKWSKPLAVASVTFAPVLLSFLWNWKRKPTSFEAGVVYLIGCLIGIALGFIAGATTKKLTPPKKWLLPWLAGGFVMSMTWSYISAQELVALLTSLGYIFGVSPSILGLTVLAWGNSIGDLITNLTMALHDGNEGAQVAVSGCYAGPIFNTLFALGISLVGCAWEAYPLSIVIKTDPRLLESLGFLVAGLVWSFLVLFSNRMRLGGVMGIGLLVIYLASLSLRIMQTVGDAH
Protein: 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8) (A3QFI1)
Organism: Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Function: Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity.
Interaction partners:
- D-amino-acid dehydrogenase
- 4-hydroxy-tetrahydrodipicolinate synthase
- Aldehyde dehydrogenase
- Pyrroline-5-carboxylate reductase
- Pyrroline-5-carboxylate reductase
Sequence:
MLKGTFFCVDAHTCGNPVRLVTSGHPDLKGRTMSEKRQDFLAQYDWIRKALMFEPRGHDMMSGAFLYPPCSDNADAAILFIETSGCLPMCGHGTIGTITAALESGLLTPKMPGQLTIDVPAGQIKVQYQQTGAKVDWVKIFNVPAYLAHKDVVLDIPGLGPLKIDVSYGGNYYAIVDPQANFPGLRHWSAGDILRWSPIVREVAHRELNCVHPDDPTVNGVSHVLWTGDTISEGSNGANAVFYGDKAIDRSPCGTGTSARLAQLYSRGELKVGDEYTHESIIGSQFVGRIEAATKVGAFDAIMPSIKGWARITGHNAITVDDNDPYAFGFQVV
Protein: Uncharacterized protein (Q581B9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPPKQHKEKKKKKKKSTPEDDLDEPYHRWLDETYYIARTHREHAAAVHMKFINTAIKACTTAIVPYNEMLLLTTGIPTCETEVVPMVSVPSIIRSLGFNPTTKQLMQIGWITALVKEPPAEFLSDVLSRTLWESENENKLKRCMLMTHIDFESCDLLTSRKKLENVGLQLLQTGSFVFDPSQVPRVFLPAVDLLRRVPVVVQRSDADTLDKVFETIWAAANTCERGTGGIRQMNIAALHKTLTTAMRSHRKTSETMEEPSLTKVEMESLLSFVCGEGGNVDEDTFALTAV
Protein: Prostaglandin E2 receptor EP4 subtype (Prostanoid EP4 receptor) (Q2N1D9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MEPTVPTIPAIMFIFGVISNLIAIVVLCKSRREQKETTFYTLVCGLAVTDLLGTVLASPVTIATYVKGAWPDGDPLCQYFGFVLLFFSLAGLSIICAMSIERYIAINHAYFYNDYVDKRLAGVTLLAIYASNILFCALPSVGFGEVKMQYPQTWCFIDWRTNVSAHAAFSYMYAGCSSLLILVTVVCNVLVCGALIRMHRRFVRRTSLGTDPQRAADPGRSRSFSRLAGAEIQMVILLIATSAVVLICSIPLVVQVFLNQLYKTPVEKRLDKNPDLLAIRFASTNPILDPWIYILLRKAVLSKVVENIKCLFCRSDSRGQQTQNSLLCINGQQFSSRDSPSGVSRELQDVSSTSQTSLNLAKAPAGGQNSSSESCRCSSHDGQCKKQSLQMSITNDSVQEKSI
Protein: Tachykinins (dTk) [Cleaved into: Tachykinin-related peptide 1 (TK-1) (dTK-1) (APTSSFIGMR-amide); Tachykinin-associated peptide 1 (TAP1) (DEEHDTSEGNWLGSGPDPLDYADEEADSSYAEN-amide); Tachykinin-related peptide 2 (TK-2) (dTK-2) (APLAFVGLR-amide); Tachykinin-associated peptide 2 (TAP2) (FIPINNRLSDVLQSLEEERLRDSLLQDFFDRVAGRDGSAV-amide); Tachykinin-related peptide 3 (TK-3) (dTK-3) (APTGFTGMR-amide); Tachykinin-associated peptide 3 (TAP3) (Brain peptide PALLAGDDDAEADEATELQQ); Tachykinin-related peptide 4 (TK-4) (dTK-4) (APVNSFVGMR-amide); Tachykinin-associated peptide 4 (TAP4) (Brain peptide DVSHQHY); Tachykinin-associated peptide 5 (TAP5) (AALSDSYDLRGKQQRFADFNSKFVAVR-amide); Tachykinin-associated peptide 6 (TAP6) (Brain peptide SDLEGNGVGIGDDHEQALVHPWLYLWGE); Tachykinin-related peptide 5 (TK-5) (dTK-5) (APNGFLGMR-amide)] (Q9VGE8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Stimulates gut muscle contractions. Required for the response to the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. The Gr68a gustatory receptor is required for detection of the pheromone and Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) which leads to courtship suppression through release of tachykinin from a cluster of 8-10 neurons in the SEZ.
Subcellular location: Secreted {ECO:0000255}.
Interaction partners:
- Short neuropeptide F
- Tachykinin-like peptides receptor 99D
- Allatostatin-A
Sequence:
MRPLSGLIALALLLLLLLTAPSSAADTETESSGSPLTPGAEEPRRVVKRAPTSSFIGMRGKKDEEHDTSEGNWLGSGPDPLDYADEEADSSYAENGRRLKKAPLAFVGLRGKKFIPINNRLSDVLQSLEEERLRDSLLQDFFDRVAGRDGSAVGKRAPTGFTGMRGKRPALLAGDDDAEADEATELQQKRAPVNSFVGMRGKKDVSHQHYKRAALSDSYDLRGKQQRFADFNSKFVAVRGKKSDLEGNGVGIGDDHEQALVHPWLYLWGEKRAPNGFLGMRGKRPALFE