wanglab/gogpt-training-data huggingface dataset:
Protein: Mitogen-activated protein kinase (EC 2.7.11.24) (Q23993)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSVSMSLVQGGAAGGAPQGASAILAAAAPYYQPPAVPQDVQPDRPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFTTSAGMRQYTADFEPSAGQPFDDLWERKLTSVQQVKEEMHKFIAEQLQTGRVPLCINPQSAAFKSFGQPMRMRKSTTTTTTTTTTTTCTAAPAAAPIRRRLLLRCPREPIQVQIEILGARSPLTRTTRYRHA
Protein: Hydantoinase/oxoprolinase family protein (Q729V7)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Histone deacetylase family protein
- beta-N-acetylhexosaminidase
- Pyridoxal phosphate biosynthetic protein PdxA
Sequence:
MFLGIDVGGTHTDAVVMDGRRVVCSCKVPTDHHDLLSSVRQAMRTLLETVEPAAVTRINLSTTLSTNAIVEGRTEEVGVVVAGGPGIDPEHVRVGRFYQSVPGSIDHRGVEIAGIDADSLDAVAGRYCREGVRVYAAVGKFSTRNPAHEQAIGGKLMECGDFVSMGHRLSGQLNFPRRVATAYYNSAVWRVYNAFADAIENAAREMGLAAPIHVLKADGGTMPLAVSREVPVESILSGPAASVMGIVALCDIREDCVILDVGGTTTDIAVFASGAPVIERDGIDVGSYATLVRALRTHSIGVGGDSRLHVQAGAVRVGPERMGPSMALGGTQPTLIDALNYMGKAHVGEVEASRRGIRDLAALWDMFPERLASEAVTTAVRRIAEAVTELVDAINARPVYTIMELLQGRRVDPVRAYVMGGPAEVLRPLLADALGRRVDVPEQYAVANAIGAALTRTTAELELFADTEKGVLFIPTLDVRREVGTRYDIEAAKRDAGQALLEHLASLGVDDDEAAVEVVEATSFNMVDDYGTAGRNIRVKCQVRPGILGA
Protein: Large ribosomal subunit protein mL50 (39S ribosomal protein L50, mitochondrial) (L50mt) (MRP-L50) (Q2KI49)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11551941}.
Interaction partners:
- Large ribosomal subunit protein mL44
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein mL63
- Large ribosomal subunit protein mL51
- Small ribosomal subunit protein bS18m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL2m
- Large ribosomal subunit protein mL39
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein mL53
Sequence:
MAALWVAGVGRKSLTVVASGAPRREFWSRLRKEKQPVVAETVEEVKKEPILVCPPLRSQAYIPPKDLQSRLESHVKEVFGSSVPTSWQEISLEDVHMKFSFLARLADDLGHAVPNSRLHQMCRVRDVLDFYTVPVQDRSKFDELIASNLPPNLKITWGY
Protein: BTB/POZ domain-containing protein 3 (Q10225)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Cullin-3
- BTB/POZ domain-containing protein 2
- BTB/POZ domain-containing protein 1
- Cullin-1
- RING-box protein pip1
- Elongin-C
- Cullin-associated NEDD8-dissociated protein 1
- Probable ubiquitin carboxyl-terminal hydrolase 12
Sequence:
MASQDQNTGTTHVELQGGENSKKLFSKYDLWSKAMDEKKLSSSLFTVNDTQEFLELCEACRRGDLEVVKSLVENYNTPINQVDQFDYSPLVLASLCGHEPVVKFLLENGALCERDTFQGERCLYGALNDNIRRMLLSYDITKAIDESQPYASHITSLLSNSALHFTTDIVFAGQYGRVFAHKFYLAARSSYFKSKFSKLGPSEHEIEVKHFAKEFESILRYLYLDTNAVFTKQYNNALLSIGKKFQLNDFIALYEKDREQLHSRDWKKIQLAKTQNDLGEFLDYIISNYKVPIESLNQPSDQYSFHDAYLQSYTHRYPVHRAIMCRCEYFLDMLAGPFLESNQELPVLSLPFSSSVVEIVLKFLYTDKTDIAPELALDVVYVADMLSLDKDRSLKSLASIVITKQEEPIDSIYDILRTAWDTSTPRLEQYASEYMANHLEHLIDDPEFCELVKESADRILQRQETDTIELIDDIRYFLSKRFGIYHEDLCIDGVVDTLTPYESEYNQKMEMIDDLLDKLELQA
Protein: Cell wall protein CWP1 (Glycoprotein GP40) (P28319)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the cell wall.
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Identified as covalently-linked GPI-modified cell wall protein (GPI-CWP) as well as protein covalently linked via an alkali-sensitive bond not requiring the GPI-derived structure. Can also be double-anchored to the cell wall through both types of linkages. Incorporated into the birth scar of a daughter cell.
Interaction partners:
- ERAD-associated E3 ubiquitin-protein ligase HRD1
- Cell wall protein SED1
- Covalently-linked cell wall protein 14
- Cell wall mannoprotein PIR3
- Congo red hypersensitive protein 1
- Cell wall mannoprotein PIR1
- Glucan 1,3-beta-glucosidase
- Mannan endo-1,6-alpha-mannosidase DFG5
Sequence:
MKFSTALSVALFALAKMVIADSEEFGLVSIRSGSDLQYLSVYSDNGTLKLGSGSGSFEATITDDGKLKFDDDKYAVVNEDGSFKEGSESDAATGFSIKDGHLNYKSSSGFYAIKDGSSYIFSSKQSDDATGVAIRPTSKSGSVAADFSPSDSSSSSSASASSASASSSTKHSSSIESVETSTTVETSSASSPTASVISQITDGQIQAPNTVYEQTENAGAKAAVGMGAGALAVAAAYLL
Protein: Non-histone protein 10 (High mobility group protein 2) (Q03435)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ino eighty subunit 5
- Chromatin-remodeling ATPase INO80
- Ino eighty subunit 1
- Ino eighty subunit 3
- RuvB-like protein 1
- RuvB-like protein 2
- Actin-related protein 4
- Ino eighty subunit 4
- Transcription initiation factor TFIID subunit 14
- Actin-related protein 5
Sequence:
MSVEEKKRRLEELKDQNVVLGLAIQRSRLSVKRLKLEYGVLLERLESRIELDPELNCEDPLPTLASFKQELLTKPFRKSKTKRHKVKERDPNMPKRPTNAYLLYCEMNKERIRQNGSLDVTRDLAEGWKNLNEQDRKPYYKLYSEDRERYQMEMEIYNKKISNIDADDDKEENEQKIKNNEEGSSTKVADSKGGEDGSLVSSN
Protein: Microcystinase C (MlrC) (Q93CA6)
Organism: Sphingomonas sp
Function: Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC). Cleaves both linear MC and the tetrapeptide degradation product of MC. Cleaves the Adda-Glu peptide bond of linear MC heptapeptides.
Interaction partners:
Sequence:
MLDRRTLMGGILSMAGSKATGAALPGRRLRVFVATLGTETNSFSPLPTGLDAFRATMLWRPGEHPDFATEATGPLWAARERAREGRYEVIEGTCAFAMPGGPVSAQAYQLLRDEILDQLRRAMPVDIVAFGLHGAMLAFGEDECEADLLERARAIVGPDVALGAELDLHAHLSQRLVRAADVLVAFKYYPHIDYVERARDLLDLLERIRAGEIMPTSSLFNCQMVAGLATQSSPMKELVADLFEFERRGEVLSGSLIQGFRAGDVARMGSKVLIYTNNDQPAAASIAQDFGRRYQAMASIMKGNGPERSFAADIELAKAATAYPVILVDSSDNPGGGASGDNMALARAMLDNDLVPSCIGPIWDPLAVQLGFEAGLGADFSLRVGGKVGEASGLPLDVRGKITGLAENVTQNLQGSRPPLGRVVCISTAGLDIIVSEIRDQCYGPDMFRALGVEPANKRYVAVKSSEQWRIGFGDMGRSVIYVASSQQSSIRHYHKRSRPMWPFEPV
Protein: Lysine-specific demethylase (EC 1.14.11.65) (A0A8I6AC36)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369087}.
Interaction partners:
Sequence:
MADAAASPVGKRLLLLFADPTASASASAPTAAAAVSGDPGPALRTRAWRAGTVRAMSGAVPQDLAIFVEFDGCNWKQHAWVKVHAEEVLALLLEGSLVWAPRKDPVLLQGTRVPVAQWPALTFTPLVDKLGLGSVVPVEYLVDRELRFMSDANGLHLFQMGTDVQNQILLEHAALRETVNALVSDQKLQEIFSRGPYSVQGHRVKVYQPEGEEAWLCGVVSRQDSISRLMEVSISETGEIKSVDPRLIHVMLMDNSTPQSESSRSSSLASSGFGVSLSSLSQPLTFGSGRSQSNGVLATENKPLGFSLSRSSASESQKDSDLSKNLFFQCMSQNLPSSNYFTSGSEGVADDSSSRDSFRQSLESLSSGLGKGRPVLGADTKPGPKAGSSVDRKVPAESMPTLTPAFPRSLLNTRTPENHENLFLQPPKLSREEPSNPFLAFVEKVEHSPFSSFASQASGSSSSATTVTSKATPSWPESHSSADSASLAKKKPLFITTDSSKLVSGVLGSALSTGGPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLLKTFSTVFGRHAGSFLSSPAEFAQENKAPFEAVKRFSLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKSGLKGPPEHLMGKLGPDGGRSAELLLGKGKGKQAPKGRPRTAPLKVGQSVLKDVSKVRKLKQSGEPFLQDGSCINVAPHLHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRLVFTRKGVLRVEGFLSPQQSDPDAMNLWIPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAWKRAVRGVREMCDVCETTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWLKCAKGQSHEPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQSKSVLRPAVTNGISQLPSITPSASSGNETTFSSGGGTVATTNPEPEQAPKGAGADSRAEEPLKAEGSASNSNSELKAIRPPCPDTAPPSSALHWLADLATQKAKEETKDAGSLRSVLSKESHSPFGLDSLNSTAKGSPLTPKLFNSLLLGPTASNSKTEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFSSSSAGAKSKASLPNFLDHIIASVVENKKTSDSSKRSCNLTDTQKEVKEMVMGLNVLDPHTSHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKLKDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDEEVLRTIDEGDADEVTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQILRKRLFEEYGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNIIYHAVKDAVGTLKAHESKLARS
Protein: Proton-activated chloride channel (PAC) (fPAC) (Transmembrane protein 206) (Q7SY31)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Displays channel activity with distinct kinetic properties compared to the human ortholog channel.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9H813}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H813}.
Interaction partners:
- MANSC domain-containing 1.
- Plexin b2a.
- Reticulophagy regulator 3
Sequence:
MPIGFNKACLKNVFTVILVLIYLALTAVAVFLAYQTISDFMDKLNHPVMSVSYKEVEEFAAPGIVLFPGKAHLLSCMHHYHDNIPPLVALENLAKRECMKEEVIYHGPYSNQTEKRALVFRGPTDVRNRELIFLQLSRNETEEDFSAISYMIFAKFSDMLESSDKAAFMMDCERNYSMWTFSGGFRTWVKMSLVRTSGRRNESVEFRQESSVVKYIDKRPPLEQTNELFFIVFQWRDPFIQQVKDIVTANPWNTIAILCGVFMALFKAADFAKLSIKWMIRIRKRHIRAKMREMNQIS
Protein: Abscisic-aldehyde oxidase (EC 1.2.3.14) (Aldehyde oxidase 3) (AO-3) (AtAO-3) (AtAO4) (Indole-3-acetaldehyde oxidase) (IAA oxidase) (EC 1.2.3.7) (Q7G9P4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: In higher plants aldehyde oxidases (AO) appear to be homo- and heterodimeric assemblies of AO subunits with probably different physiological functions. AO-delta may be involved in the last step of abscisic acid biosynthesis, at least in leaves and seeds. In vitro, AO-delta oxidizes abscisic aldehyde to abscisic acid (ABA). In vitro, AO-delta also uses 1-naphthaldehyde, indole-3-aldehyde (IAld), benzaldehyde and cinnamaldehyde as substrate; the AAO2-AAO3 dimer also uses abscisic aldehyde as substrate.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Xanthoxin dehydrogenase
- Abscisic acid 8'-hydroxylase 2
- Abscisic acid 8'-hydroxylase 1
- Abscisic acid 8'-hydroxylase 3
- Abscisic acid 8'-hydroxylase 4
- Molybdenum cofactor sulfurase
- Zeaxanthin epoxidase, chloroplastic
- 9-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic
- Beta-D-glucopyranosyl abscisate beta-glucosidase
- 9-cis-epoxycarotenoid dioxygenase NCED9, chloroplastic
Sequence:
MDLEFAVNGERFKIDSVDPSTTLLEFLRLNTPFKSVKLGCGEGGCGACLVVLSKYDPELDQVKECCINSCLTLLCSVNGCSITTSEGLGNTKKGFHPIHKRFAGFHASQCGFCTPGMCISLYSSLANAENNSSKDFTVSEAEKSVSGNLCRCTGYRPIVDACKSFASDVDIEDLGLNSFWKKGESKEVMFKNLPPYNPKDHLVTFPEFLKKKEKVDNGSDHLKYRWTTPFSVAELHNIMEAANSGDSLKLVVGNTGTGYYKDEERFDRYIDISNIPEMSMIKKDEKGIEIGAAVTISNAIDALEKESKSSYVFKKMATHMEKIGNRSIRNSGSIGGNLVMAQSRKFPSDVTTLLLAVDASVYMLNGRKTEKVTLQEFLELSPVLDSKRVLLKVEIPSWTAPSGDDTEFLFESYRAAPRSIGNALPYLNAAFLALVSRQEASRKGVTVEKCFLAFGSYGGDHSIRAIEVETFLTGKLLSYSVLYEAVGLLKGIIVPGKDTLHSEYRKSLAVGYLFEFFYPLIESGHRICSLDSGNKHNNSHVDTVKSLPFLSSSQQVLESNEFKPIGEAVIKVGAALQASGEAVFVDDIPTLPDCLHGAFIYSTEPLAKIKSLSFRENVTPTGVFAVLTFKDIPQQGQNIGSKTLFGPGPLFADELTRCAGQRIALVVADTQKHADMAAKLAVVEYDTKNLEQPILTVEDAVKRSSFFEVHPMFYPEPVGDVIKGMEEAERKIISSELRLGSQYFFYMEPQTALALPDEDNCVKVFSSSQAPEYVHSVIATCLGIQEHNVRVITRRVGGGFGGKAVKSMPVATACALGAYKLQRPVKMFLNRKTDMIMAGGRHPMKINYNVGFRSDGKLTALELTMLIDAGLEPDVSPIMPRNIMGPLRKYDWGALSFDVKVCKTNCLSRTAMRAPGEVQGSYIAESIIENVASSLQMDVDAVRKINLHTYDSLRKFYNHIAGDPDEYTLPLLWEKLEISSKFKERSEMVKEFNLCNVWRKRGISRVPIVHQVMQRPTPGKVSILSDGSVVVEVGGIEIGQGLWTKVQQMVAYGLGMVKCEGNEKLLDRIRVVQSDTLGMIQGGFTAGSTTSESSCEAVRLCCVILVERLKPIMDQMMMEKSGSVTWNILIQQAYGQYINLSASTLYKPEYSSMEYLNYGVGVSEVEVDLVTGKTEILRSDIIYDCGKSLNPAVDLGQTEGAFVQGIGFFMMEEYTTDEKGLVVQQGTWDYKIPTVDTIPKHFNVEIVNTGHHKNRVLSSKASGEPPLLLAASVHCATRSAIREARKHSLSSNFIDGSDSEFELPVPATMPVVKSLCGLYSVEKYLQGKIKGQ
Protein: Sterol O-acyltransferase 2 (EC 2.3.1.-) (ASAT) (Sterol-ester synthase) (P84285)
Organism: Candida albicans (Yeast)
Function: Sterol O-acyltransferase that catalyzes the formation of stery esters.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15184069}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGRTNTSDQLNAISDKNTKRKSLALDNEYHNNSSSEDDSSKIELSYTIPDNNNIISQETTTSVEDVLSLSSAPQNELRLRKQKSNNQDSPVDLNGVIVDVSKREKIFLKRKRQIDNKHGSDKSKYLSRFNDITFKAKSSTIFESDEFYKTDFFGMYVLFWLATAFAMVNNLIHTYFENSTPILQWTVVKVFKRDLFKVGLVDLAMYLSTYFAFFVQYACKNGYLSWKKVGWWLQAAFDGLFLFFWLWIASEYCLDFPWIAKVFLVLHSLVFIMKMHSYAFYNGYLWSIYKEGLYSEKYLDKLTNGKVTLPKGHTKNETEKVLQESIAFTKYELEYQSHATTENPDDHHVFDIDQTDKSIAKLQQEGLIKFPQNITLFNYFEYSMFPTLVYTLNFPRTKRIRWSYVFGKTFGIFGLIFLMILIAENNLYPIVLRCEIARKLPVSERIPQYFFLLMDMIPPFLMVYLFTFFLIWDAILNAIAELSKFADRDFYGPWWSCTDFSEFANQWNRCVHKFLLRHVYHSSISAFDVNKQSAAIITFLLSSLVHELVMYVIFGTLRGYLLLFQMSQIPLIIMSRSKFMKDKKVLGNIICWFGFISGPSIICTLYLVF
Protein: Grasp65 (Q9VW57)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
Interaction partners:
- GH05665p
- Golgi matrix protein 130 kD
- General vesicular transport factor p115
- Syntaxin-5
- Protein transport protein SEC23
- WD40 repeat-containing protein SMU1
- Golgi microtubule-associated protein, isoform D
- Secretory 24CD, isoform C
- Serine/threonine-protein kinase polo
- Golgin-84
Sequence:
MGSSHSIHVPGGGTEGYHVLKVQDNSPGQKAGLEAFFDFIVAIAGTRLDQDNDMLKELLRQNVDKPVRLTVYSSKTQTVRELTLTPSNNWGGQGLLGVSIRFCSFEGANESVWHILEVHPNSPAELAGLRAYSDYVIGADAIRHENDDLFTLIETHEQQPLKMYVYNLDDDACREVTIKPNTAWGGEGALGCGIGFGYLHRIPVQAEPVTSSSAAVPAAAAAESTAPLLTAGGAAPAGAQVAQVVSPTLPYIPPLANTFGSTNAEVRPPTIEPPAQSLFKTYFNPDEATDALTAALESQATIAEPVSVPAPPAVADVSVAQPQVQVPAPAQPLPPPANIFIPGVFDPSTQQNANALGGIPAAQLPFPQATAAPAAVPMFSAPQQAYMSAPAALSYPAGAQTVPSYPQVQPSMGGLFPTQPTPLPPQMAHVFAPPVPPQAGAAPAAGNDELSGPAVNQAGN
Protein: Self-incompatibility protein S1 (Q40975)
Organism: Papaver rhoeas (Common poppy)
Function: Exhibits specific pollen self-inhibitory activity thus preventing self-fertilization.
Subcellular location: Secreted {ECO:0000305|PubMed:8134385}.
Interaction partners:
Sequence:
MNIFYVIVLLSFFLSKSSGFFPVIEVRIMNRRGNGRSIGIHCRSKDNDLQNQTVTSGHDMSFSFREDFFHTTHFYCDLQWDKETKFGFYSYQAKRDDDGRCSSQCLWKIMDDGLYGFDQEHQIWQIYHLIKKERKEGRT
Protein: Nebulin (Q62412)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
FTSVTDSLEQVLAKNNAITMNKRLYTEAWDKDKTQIHIMPDTPEIMLARMNKVNYSESLYKLANEEAKKKGYDLRSDAIPIVAAKASRDIASDYKYKDGYRKQLGHHIGARNIKDDPKMMWSMHVAKIQSDREYKKDFEKWKTKYSSPVDMLGVVLAKKCQILVSDIDYKHPLHEWTCLPDQNDVIHARQAYDLQSDNVYKSDLQWMRGIGWVPIGSLDVVKCKRAAEILSDNIYRQPPNKFKFTSVTDSLEQVLAKSNALNMNKRLYTEAWDKDKTQIHIMPDTPEIMLARQNKINYSESLYRQAMEEAKKEGYDLRSDAIPIVAAKASRDIASDYKYKEAYRKQLGHHIGARAIHDDPKMMWSLHIAKVQSDREYKKEFEKYKTRYSSPVDMLGIVLAKKCQTLVSDVDYKHPLHEWTCLPDQNDVIQARKAYDLQSDNLYKADLEWMKGIGWVPIGSLEVVKAKRAHEILSDNIYRQRPDTLKFTSITDSLEQVLAKNNAITMNKRLYTEAWDNDKKTIHVMPDTPEIMLAKLNRINYSDKLYKVSLEEARRQGYDLRVDAIPIRSAKASREIASDYKYKEGYRKQLGHHIGARNIKDDPKMMWSMHVAKIQSDREYKKDFEKWKTKYSSPVDMLGVVLAKKCQILVSDIDYKHPLHEWTCLPDQNDVIQARKAYDLQSDAVYKADLEWLRGIGWVPIGSVEVEKVKRAGEILSDRKYRQPADQLKFTCITDTPEIVLAKSNAITMSKHLYTEAWDADKASIHVMPDTPEILLAKSNSANISHKLYTKGWDESKMKDYDLREDAISIKSAKASRDIASDYKYKEAYEKQKGHHIGAQSVEDDPRILCAMHAGKIYSDREYKKEFQKWKTKFSSPVDMLGVVLAKKCQTLVSDVDYRNYLHNWTCLPDQNDIIQAKKAYELQSDSVYKADLEWLRGIGWMPEGSIEMTRVKGAQDLVNERLYRTRPEALKFTSIVDTPEVVLAKANSLQMSERLYQEAWNKDKTNISLPLDTPAMLQAQINALQISNKLYQKDWDEAKQKGYDLRADAIEIKHAKASREIASEYKYKEGYRKQLGHHVGFRSLQDDPKLVWSIHAAKIQSDREYKKAYEKSKGIYNTPLDMMSIVQAKKCQVLVSDVDYRNYLHQWTCLPDQNDVIQAKKAYELQSDNVYKSDLPWMKGIGWLTEGSV
Protein: Clathrin interactor 1 (A0A0G2JW94)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Clathrin heavy chain 1
- AP-1 complex subunit beta-1
- Phosphatidylinositol-binding clathrin assembly protein
- Epidermal growth factor receptor pathway substrate 15
- Clathrin light chain B
- Clathrin coat assembly protein AP180
- Cyclin-G-associated kinase
- Clathrin light chain A
- AP-2 complex subunit alpha
Sequence:
MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYNERYDPEPKSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKARRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASPDQNASTHTPQSSAKPSVPSSKSSGDLVDLFDGSGQTTGGATDLFGGFADFGSAAASGSFPSQATSGNGDFGDWSAFNQAPSGPVASGGELFGSAPQPAVELISGSQPALGPPPAASNSSDLFDLMGSSQATMTSSQSMNFSLMSTNTVGLGLPMSRSQPLQNVSAVLQKPNPLYNQNADMVQKSASKTLPSTWSDPSVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPLNVMTQSFGAVNLSSPSNMLPVRPQTNPLMGGPMPMNMPGVMTGTMGMAPLGNTAGMSQGIVGMNMNMGMSASGMGLTGTMGMGMPSMAMPSGTVQPKQDAFANFANFSK
Protein: Heterogeneous nuclear ribonucleoprotein A0 (B5X3S8)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MTNQLCKLFVGGLNVETTDDGLRQHFEQYGQLTDCVVVQNQQLQRSRCFGFVTYSSAEEADAAMAARPHVVDGTNVELKRAVAREDAGRPEALAKVKKIFIGGLKDDIEDDHLNDYFSQFGAIEKAEVISDKQTLKKRGFGFVYFEDNDSADKAVVLKFHTINGHKVEVKKALTKQEMQSAGGRGRGGRGMRGSQNGYDGGRGGGYGNYGGNYGGNDGGYGGGYGNGGGYGNQGGYGGGYGDQMGSSYGGNGYNDFGEDYGQQSSGYGAMKGGNYSGRSAAPYSRGGGSGYSRGGYGGY
Protein: Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF) (O43915)
Organism: Homo sapiens (Human)
Function: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Subcellular location: Secreted.
Interaction partners:
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor receptor 3
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor B
- Vascular endothelial growth factor C
- Lymphatic vessel endothelial hyaluronic acid receptor 1
- Neuropilin-2
- Fibroblast growth factor receptor 1
- High affinity nerve growth factor receptor
- Angiopoietin-1 receptor
Sequence:
MYREWVVVNVFMMLYVQLVQGSSNEHGPVKRSSQSTLERSEQQIRAASSLEELLRITHSEDWKLWRCRLRLKSFTSMDSRSASHRSTRFAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRRSIQIPEEDRCSHSKKLCPIDMLWDSNKCKCVLQEENPLAGTEDHSHLQEPALCGPHMMFDEDRCECVCKTPCPKDLIQHPKNCSCFECKESLETCCQKHKLFHPDTCSCEDRCPFHTRPCASGKTACAKHCRFPKEKRAAQGPHSRKNP
Protein: Variant-surface-glycoprotein phospholipase C (VSG lipase) (EC 4.6.1.14) (Glycosylphosphatidylinositol-specific phospholipase C) (GPI-PLC) (P09194)
Organism: Trypanosoma brucei brucei
Function: By hydrolysis of the attached glycolipid, releases soluble variant surface glycoprotein containing phosphoinositol from the cell wall of T.brucei after cell lysis. It also cleaves similar membrane anchors on some mammalian proteins. VSG lipase may play a role in processes such as parasite differentiation or antigenic variation.
Subcellular location: Membrane; Peripheral membrane protein.
Interaction partners:
Sequence:
MFGGVKWSPQSWMSDTRSSIEKKCIGQVYMVGAHNAGTHGIQMFSPFGLDAPEKLRSLPPYVTFLLRFLTVGVSSRWGRCQNLSIRQLLDHGVRYLDLRMNISPDQENKIYTTHFHISVPLQEVLKDVKDFLTTPASANEFVILDFLHFYGFNESHTMKRFVEELQALEEFYIPTTVSLTTPLCNLWQSTRRIFLVVRPYVEYPYARLRSVALKSIWVNQMELNDLLDRLEELMTRDLEDVSIGGVPSKMYVTQAIGTPRNNDFAVAACCGACPGSHPDLYSAAKHKNPHLLKWFYDLNVNGVMRGERVTIRRGNNTHGNILLLDFVQEGTCTVKGVDKPMNAVALCVHLNTNQTARS
Protein: Kelch-like ECH-associated protein 1B (A0A2R8Q1W5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting nfe2l2/nrf2 nuclear accumulation and expression of phase II detoxifying enzymes (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Z2X8}. Nucleus {ECO:0000250|UniProtKB:Q9Z2X8}. Note=Mainly cytoplasmic. {ECO:0000250|UniProtKB:Q9Z2X8}.
Interaction partners:
- Cullin 3
- Nuclear factor
- Nuclear factor, erythroid 2-like 2b.
- Kelch-like protein 9 isoform X1
- Kelch-like family member 13
- E3 ubiquitin-protein ligase RBX1
- Rho-related BTB domain-containing 1.
- Rho-related BTB domain-containing 2b.
- Rho-related BTB domain-containing 2a.
- Kelch-like ECH-associated protein 1A
Sequence:
MTECKAEVTPSASNGHRVFSYTLESHTAAAFAIMNELRRERQLCDVTLRVRYCPLDTHVDFVAHKVVLASSSPVFRAMFTNGLKECGMEVVPIEGIHPKVMGRLIEFAYTASISVGEKCVIHVMNGAVMYQIDSVVQACCDFLVEQLDPSNAIGIASFAEQIGCTELHQKAREYIYMNFSQVATQEEFFTLSHCQLVTLISRDELNVRCESEVFHACVAWVQYDREERRPYVQALLQAVRCHSLTPHFLQRQLEHFEWDAQSKDYLSQIFRDLTLHKPTKVIPLRTPKVPQLIYTVGGYFRQSLSFLEAFNPCSGAWLRLADLQVPRSGLAACVISGLLYAVGGRNNGPDGNMDSHTLDCYNPMNNCWRPCAHMSVPRNRIGVGVIDGMIYAVGGSHGCTHHNSVERYDPERDSWQLVSPMLTRRIGVGVAVINRLLYAVGGFDGTHRLSSAECYNPERDEWRSIAAMNTVRSGAGVCALGNYIYVMGGYDGTNQLNTVERYDVEKDSWSFSASMRHRRSALGVTTHHGRIYVLGGYDGNTFLDSVECFDPETDSWTEVTHMKSGRSGVGVAVTMEPCHKELIPCQC
Protein: Putative exoribonuclease DIS3 (Q9BI20)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQTLREFTRKTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTNVVLDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAKAEAEGILVTTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIEDTNRHIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCRELPNGNLEVGVHIADVSHFIRPGKRTGHGGSGPGETTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKEEDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVETTTEGTDSQAVSAAPPSKKTKKDKKKK
Protein: Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1) (Q8TA86)
Organism: Homo sapiens (Human)
Function: Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- U4/U6 small nuclear ribonucleoprotein Prp31
- U4/U6 small nuclear ribonucleoprotein Prp3
- Pre-mRNA-processing-splicing factor 8
- Fascin-2
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Peripherin-2
- Inosine-5'-monophosphate dehydrogenase 1
- E3 ubiquitin-protein ligase Topors
- Ceramide kinase-like protein
- Kelch-like protein 7
Sequence:
MSSRPGREDVGAAGARRPREPPEQELQRRREQKRRRHDAQQLQQLKHLESFYEKPPPGLIKEDETKPEDCIPDVPGNEHAREFLAHAPTKGLWMPLGKEVKVMQCWRCKRYGHRTGDKECPFFIKGNQKLEQFRVAHEDPMYDIIRDNKRHEKDVRIQQLKQLLEDSTSDEDRSSSSSSEGKEKHKKKKKKEKHKKRKKEKKKKKKRKHKSSKSNEGSDSE