wanglab/gogpt-training-data huggingface dataset:
Protein: Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) (Q7Z6M1)
Organism: Homo sapiens (Human)
Function: Rab9 effector required for endosome to trans-Golgi network (TGN) transport.
Subcellular location: Cytoplasm. Endosome membrane {ECO:0000269|PubMed:14530284}. Note=Interaction with PIKFYVE and subsequent phosphorylation recruits it to the endosomal membrane. {ECO:0000269|PubMed:14530284}.
Interaction partners:
- Vesicle-associated membrane protein 3
- Perilipin-3
- Mitochondrial import inner membrane translocase subunit Tim21
- Ras-related protein Rab-9A
Sequence:
MKQLPVLEPGDKPRKATWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKEDSNSLTLNHEAEKEDSADKVMSHSGDSHEESQTATLLCLVFGGMNTEGEIYDDCIVTVVD
Protein: E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (xPOSH) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (Q6NRD3)
Organism: Xenopus laevis (African clawed frog)
Function: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway (By similarity). Plays an essential role in the anterior neural development.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q71F54}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q69ZI1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q69ZI1}.
Interaction partners:
Sequence:
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVSSRKELRCPECRTLVECGVDELPSNILLVRLLDGIRQRPRKAGDGGSAGNSTNALRAQGSVTTNGGLNDAQNTQSGQQRIQARSPPVRGVPQLPCAKALYNYEGKEPGDLKFNKGDIIVLRRQVDENWYHGEINGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFLKDDILTVIRRVDENWAEGMLGDKIGIFPISYVEFNSAAKQLIELDKPSGADTGEGSSGTSHSGNSQKQADAKKNTKKRHSFTSLTMSNKSSQSVQNRHSMEISPPVLISSSNPTAAARISELTGLSCSAPSQDMNPPLLPPPPMATPVITSASSGAAAVAQRNIIGPVEQVPHLRTSARPSVFIAIYPYIPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRALTTATPAKVAMATATTSNVVNLVTPTPPGAPCQKLPVSGVEFAKTSSTNGVSPAGVPGCHIQTSPQSKVLLHMSGQMTVNQARNAVRTAAAHSQDRPTAAVTPIQAQTPAASALPQQAAASQQVPPPLSAPAAYINAAMNISRPSVPAASAASSALPTAAFEAESSWKSSSGLSGCSFSENVSAPLNSAANKQDKDSKKEKKGLLKLLSGASTKRKPRSSPPHSPTQEVEQTNSEAAAALEGAVGPDIVPVIVNGRAAPCTVDCDSVSASTPAQDNRKPASLDNNIPIAPPPRQPCSSLGSVLNDSRPCERYRVMVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI
Protein: 26S proteasome regulatory complex subunit p50 (GH12068p) (Regulatory particle triple-A ATPase 5 (EC 5.6.1.5)) (Q9V3V6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- 26S proteasome regulatory subunit 4
- GH11341p
- Proteasomal ubiquitin receptor ADRM1 homolog
- Proteasome subunit alpha type-5
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 13
- Regulatory particle triple-A ATPase 4
- 26S proteasome non-ATPase regulatory subunit 14
Sequence:
MAQTLEDKSIWEDGEESLGEEVMRMSTDEIVSRTRLMDNEIKIMKSEVIRITHEIQAQNEKIKDNTEKIKVNKTLPYLVSNVIELLDVDPQEEEDDGSVTVLDNQRKGKCAVIKTSTRQAYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPAEYDARVKAMEVDERPTEQYSDIGGLDKQIQELIEAVVLPMTHKEKFKNLGIHPPKGVLLYGPPGTGKTLLARACAAQTKSTFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPAIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFSSTADIKVIAATNRVDILDPALLRSGRLDRKIEFPHPNEEARARIMQIHSRKMNVSNDVNFEELSRSTDDFNGAQCKAVCVEAGMIALRRSANSVTHEDFMDAIMEVQAKKKANLNYYA
Protein: Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) (Q9UKV0)
Organism: Homo sapiens (Human)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Histone acetyltransferase KAT5
- Histone deacetylase 1
- Myocyte-specific enhancer factor 2B
- Nuclear receptor corepressor 1
- Histone acetyltransferase p300
- Forkhead box protein P3
- Myocyte-specific enhancer factor 2A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Nuclear receptor corepressor 2
- Myocyte-specific enhancer factor 2C
Sequence:
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS
Protein: Probable serine/threonine-protein kinase PBL23 (EC 2.7.11.1) (PBS1-like protein 23) (F4JEQ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in plant defense signaling.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O48814}; Lipid-anchor {ECO:0000250|UniProtKB:O48814}.
Interaction partners:
- At4g12735
- F-box protein At5g03100
- Transmembrane protein, putative
- Beta-glucosidase 8
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Protein SODIUM POTASSIUM ROOT DEFECTIVE 2
- Amidophosphoribosyltransferase 3, chloroplastic
- Protein TRANSPARENT TESTA 9
- Amidophosphoribosyltransferase 1, chloroplastic
- UDP-galactose/UDP-glucose transporter 3
Sequence:
MKINCLFCCMSHRRFNRRSSSRQSIKDCIDAKNNITTFDNISFKTDSSRRRYISEEIAKLGKGNISAHIFTFRELCVATKNFNPDNQLGEGGFGRVYKGQIETPEQVVAVKQLDRNGYQGNREFLVEVMMLSLLHHQNLVNLVGYCADGDQRILVYEYMQNGSLEDHLLELARNKKKPLDWDTRMKVAAGAARGLEYLHETADPPVIYRDFKASNILLDEEFNPKLSDFGLAKVGPTGGETHVSTRVMGTYGYCAPEYALTGQLTVKSDVYSFGVVFLEMITGRRVIDTTKPTEEQNLVTWASPLFKDRRKFTLMADPLLEGKYPIKGLYQALAVAAMCLQEEAATRPMMSDVVTALEYLAVTKTEEDGQTVEGEEEEEEDERSKL
Protein: Pentatricopeptide repeat-containing protein At1g51965, mitochondrial (Q9ZU27)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000305|PubMed:25732537}.
Interaction partners:
- RCC1 domain-containing protein RUG3, mitochondrial
- NADH dehydrogenase subunit 2.
- NADH-ubiquinone oxidoreductase chain 2
- Transmembrane 9 superfamily member 4
- Nuclear intron maturase 1, mitochondrial
- DEAD-box ATP-dependent RNA helicase 53, mitochondrial
- Transcription termination factor MTERF15, mitochondrial
- RNA helicase
- Nuclear intron maturase 4, mitochondrial
- Nuclear intron maturase 2, mitochondrial
Sequence:
MKLLRRRFFNSVNTITRPNRRHYATKYVAKVTSSSPSGRSLSAEVSLPNPLPADVRGYPLPRRHLICRATNLITGASNLSDAFSDLSDYLSSLSLSLTPDEASEILKSLNSPLLAVEFFKLVPSLCPYSQNDPFLYNRIILILSRSNLPDRFDRVRSILDSMVKSNVHGNISTVNILIGFFGNTEDLQMCLRLVKKWDLKMNSFTYKCLLQAYLRSRDYSKAFDVYCEIRRGGHKLDIFAYNMLLDALAKDEKACQVFEDMKKRHCRRDEYTYTIMIRTMGRIGKCDEAVGLFNEMITEGLTLNVVGYNTLMQVLAKGKMVDKAIQVFSRMVETGCRPNEYTYSLLLNLLVAEGQLVRLDGVVEISKRYMTQGIYSYLVRTLSKLGHVSEAHRLFCDMWSFPVKGERDSYMSMLESLCGAGKTIEAIEMLSKIHEKGVVTDTMMYNTVFSALGKLKQISHIHDLFEKMKKDGPSPDIFTYNILIASFGRVGEVDEAINIFEELERSDCKPDIISYNSLINCLGKNGDVDEAHVRFKEMQEKGLNPDVVTYSTLMECFGKTERVEMAYSLFEEMLVKGCQPNIVTYNILLDCLEKNGRTAEAVDLYSKMKQQGLTPDSITYTVLERLQSVSHGKSRIRRKNPITGWVVSPL
Protein: Ribosomal protein L24 (O77067)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MRTIDCEFSHFAVHPGHGRRYVPFAFLSTKPVLTFARPKCFAMYMRKKNPRFIAWTRTYRRIHRKTTTDRVGRRRAARTVRAERAIVGAELSYIQEVRAKAKKVDRTAKGKAVREEMAARKAAKK
Protein: Forkhead box protein Q1 (HNF-3/forkhead-like protein 1) (HFH-1) (Hepatocyte nuclear factor 3 forkhead homolog 1) (Q9C009)
Organism: Homo sapiens (Human)
Function: Plays a role in hair follicle differentiation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Interaction partners:
- GDP-mannose 4,6 dehydratase
- Cytochrome P450 1B1
Sequence:
MKLEVFVPRAAHGDKQGSDLEGAGGSDAPSPLSAAGDDSLGSDGDCAANSPAAGGGARDTQGDGEQSAGGGPGAEEAIPAAAAAAVVAEGAEAGAAGPGAGGAGSGEGARSKPYTRRPKPPYSYIALIAMAIRDSAGGRLTLAEINEYLMGKFPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWMLNPNSEYTFADGVFRRRRKRLSHRAPVPAPGLRPEEAPGLPAAPPPAPAAPASPRMRSPARQEERASPAGKFSSSFAIDSILRKPFRSRRLRDTAPGTTLQWGAAPCPPLPAFPALLPAAPCRALLPLCAYGAGEPARLGAREAEVPPTAPPLLLAPLPAAAPAKPLRGPAAGGAHLYCPLRLPAALQAASVRRPGPHLPYPVETLLA
Protein: Ubiquitin-conjugating enzyme E2 variant 2 (Ubc-like protein MMS2) (Q9D2M8)
Organism: Mus musculus (Mouse)
Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 N
- Ubiquitin-ribosomal protein eS31 fusion protein
- Helicase-like transcription factor
- Ubiquitin-conjugating enzyme E2 A
- Ubiquitin-conjugating enzyme E2 W
- Ubiquitin-conjugating enzyme E2 B
- Polyubiquitin-C
- E3 ubiquitin-protein ligase RNF8
- Polyubiquitin-B
- Ubiquitin-conjugating enzyme E2 G1
Sequence:
MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVILQELRRLMMSKENMKLPQPPEGQTYNN
Protein: MHC class Ib antigen (Q6W9J7)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MESSAFFTLLFTLYLLLGASLALAQTFKGSHSLRYFDIAVSRPGLEETHYMTVGYVDDTEFVHFDNEAENPRFEPRVPWMEQMGQKYWDDQTRIAKAAEQQIRVYFQKLRDYYNQSQNSSHTIQRMTGCYIGPDGHLLHAYRQFGYDGQDYLTLNEDLSTWTAADAAAVVTRREWEATNVAEFWRVYLEGPCMVWLFKYLTVGNETLLRTEPPKAYVTHHPRPEGDVTLRCWALGFYPSDIIMIWQRDGEDQTQDMDVIETRPAGDGTFQKWASVVVPSGKEQNYTCHVHHEGLPEPLTLRWSRPPQSFIFIIIVAVGLVLLGASVATLVMWKKSSGGERGSL
Protein: Carnitine O-palmitoyltransferase I (EC 2.3.1.21) (Q2UZM8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAEAHQAVAFQFTVSPDGIDLQLSHEALRQIYLSGLHSWKKKFIRFKNGVMTGVYPGSPTGLMLVVGLYMGRAKYVQADPSLALFTKVGAHLPVSRYMSFEKQQVVGGVLVGTGLWVAIFFTMRTALKWLLSWHGWMYAHHGTVSWRTRIWLVLVKIFSGRRNPQLYSFQTSLPQLPLPSVKDTINRYLESAHPLMDDEQYLRMEGLAKDFEKGLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPIMVNSNYYAMDFLYVFPTSLQAARAGNAIHAIMLYRRMLDRAQIKPLMLQNTIPMCSAQYERMFNTSRIPGVDTDTIQHMQDSRHIVVYHRGRYFKVPMFYDGKVLSPRAVEQQMERILADPSEPQPGEECLAALTAGDRVPWAEAREAYLRQGRNQQALDTVEKAAFFVTLDDTEQRYKAEDPVRSLDSYAKSLLHGKCYDRWFDKSFNLIVFRNGTMGLNAEHSWADAPIIGHLWEHVLSMDPVKLGYTEEGHCKGNPHPSLPGPQRLQWNIPAECQTAIASSLMVAKALADDVDSHIIPFNCFGKGLIKKCRTSPDAFIQIALQLAHFRDKGRFCLTYEASMTRMFREGRTETVRSCTVETCAFARSMVEDNPRELRLKLLKEAATRHQQLYRLAMTGGGIDRHLFCLYVVSKYLGEDSAFLKEVLSEPWRLSTSQTPLQQVELFDLARHPEYVSSGGGFGPVADDGYGVSYIILGENLINFHISSKHSSPETDSHRFGNLIKQAMLDILALFQLDANALA
Protein: Ubiquitin carboxyl-terminal hydrolase-related protein (F4IGQ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKRTTFLEDAERVKLYNDARALFANGDHIKALEIIEDIILVHKEDEKSWILHSEQGEMFNDLAGKAENPYVDFTYMLGSVGCYSKDVLLSRPWAHGLHYLAQESGSVMYYKKCVNVAKQGLSVTFPDASESFAQLLLENLKNDMKENLETLIKDAESNIADSKTVELKGLLQQDFEPEVLESKKRPELVKNEFKGLRSFWLGLDVNVKRDFMKVSIAKLIGFVKGVHHRPGRDALKQILDSAKEDRKWTFWMCRTKCSKKFSSAEECKNHLEKEHAADYKPFSEMDMAKRIGKDWTRKISLGSWEPVDIAAAVEMIKNRLPEVKAFSYKNGWSKEWPLAEDEERSKLLKEIKFFLVMFCDLKILPCSIRDWMKRYSVTHLKNLNVSEQSLVDSHLVDTPQSICFLECHKLSYILNLLKRIKCERDDGTNLVRRAVDSILDSTRSKEKIDFDPQFSFLLLDRRLLKSNNGPFVDEGEINVFDPNVHYAKAHAQGDDIVSWLTDYNSVEKTFPRPIREHNLDIWVAVLRAVQFTCRTFGTKYAKKVQLFDYLAAIVAAEKLCKSEYERRRKLKEDQWNSYASLLCDKCEECFSRKNFLKRKLFLSVVRDILEEASDLTFDLPDIEGCMNLIREHKSLNDDIVLKSLICLNSVVIFKILLIDSKILLVDNSRISLLNNLTRLSLFDNRTYILQLLKPFLLNEIVNMESKAKSDAAVADLLLEEEKKNPKPSPIQSKKKKNTSKKRNSTSMSSPLSKPGEHLEPETTSPTVEEDSMELGDTVNQEEVMKNMLGEDSQSEHLESALSEASARYNSALDMTLKALLNIKILKEDLMHNMQPLQHHLEDQVPSVLQNFFTAFVSEEIKTEGVYSYLLSDLLALLEEVLSMSSGAAEVLVAILEFWHCWKNAERESLVTRLFTLEEKERMSCRKCRKKPNYPEQSSYGIVMAADSIRDLKCALGNIEFVDILKVIRMDYTMLCDIKNGGCGIANFIHHIISKCPPIFTIVLEWEKSETEKEISETTKAFEWEIDISRLYAGLEPKTNYRLASMVGCDEKQEHICIAYEKNRWVNLRRDALAGEDVGNWKSVVRFCGERKVRPEILFYEVVRSMA
Protein: Uncharacterized protein (Q382W4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVASEANDVVSFLSKVGERYKQHRELLRRKFLEDERRDCPFKPTLSKYTSHRKPSKGSECVEAVEKRLYQLHVRQQELAEERQAAHNKRESAELKAVMRPPRLTAQARSLSPRDPAEVSRQWLQKREEKLIRLREAIIKGDLDAMQSKPTISSYAEANITAERRNGKSIEDYLLAEHEARRERMHHHYEGGTTASGRSSSPLRRVDSQPVFRPRISNYARRLSLPGRVVDRLLSKKSRKGDALRDENCTFAPRVSSTSTRLLRYFYKNPNVSVYDRLCDESYMRPNGCYAKKGSSHVEPGSFGVPHINETSRAIVERKRTGDDAPLRTYQLRSPTERLHACRDPTASSGRHRRHCQHMISEQLEKEISQCTFRPRVDEESNQMWRRRLQQLKGGGHPRNVSGLRELLWRRSETRMKEELRRQRELQEQKEVEECTFHPKVGRAPRRRVECALSVPERNEAWQQRRQKKLNCTREEVERSETSECSFHPSVSSLHSAASVPASNVAGYDSHLRRHAESRRIIREMQEWWRPKSHISRNSGSARRVRSQPQKREKEWWDLPQKCELSSFTRTCSPTSWDDQLSSSQLGS
Protein: Acyl-[acyl-carrier-protein] dehydrogenase MbtN (Acyl-ACP dehydrogenase MbtN) (EC 1.3.99.-) (Mycobactin synthase protein N) (P9WQF9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the dehydrogenation at the alpha-beta position of ACP-bound acyl chains. This results in the introduction of a double bond in the lipidic chain, which is further transferred to the epsilon-amino group of lysine residue in the mycobactin core by MbtK.
Interaction partners:
- Medium/long-chain-fatty-acid--[acyl-carrier-protein] ligase MbtM
- Acyl carrier protein MbtL
- Probable fatty oxidation protein FadB
- Lysine N-acyltransferase MbtK
- Electron transfer flavoprotein subunit beta
- Electron transfer flavoprotein subunit alpha
Sequence:
MTAGSDLDDFRGLLAKAFDERVVAWTAEAEAQERFPRQLIEHLGVCGVFDAKWATDARPDVGKLVELAFALGQLASAGIGVGVSLHDSAIAILRRFGKSDYLRDICDQAIRGAAVLCIGASEESGGSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADHIMVVARSVDHDPTSRHGNVAVVAVPAAQVSVQTPYRKVGAGPLDTAAVCIDTWVPADALVARAGTGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMSRRQFGQTLFEHQALRLRMADLQARVDLLRYALHGIAEQGRLELRTAAAVKVTAARLGEEVISECMHIFGGAGYLVDETTLGKWWRDMKLARVGGGTDEVLWELVAAGMTPDHDGYAAVVGASKA
Protein: histidine kinase (EC 2.7.13.3) (O52237)
Organism: Myxococcus xanthus
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAHNGSIGGHADMSSGRGINRCQGTEGDEPLSEAVVVLRNVRSAVGGIVDFECVSANVHAERWLGGEEGSLVHNRLLEEAPWAWDGGLFSACVRVVTRRAPEIARVSRQSPMGTVWLLARVSPCDDGVVLFLEDLTERMAAEEALRRDHDLLHAVIESATDAIYVKDVSGRYILINPATASAFHRAPREILGRTDAELLGADRAAPTLAHDREVMSSGHTATYEGAEGGPGTDRIWHTTKGVLRRGDGTVYGLFAICRDVTARRRQELEREEEARFQERFIGVLGHDLGNPLAAVRLSSAALLARDTLPPEVRRVVARIDGSAERMARLVKQLLDFTRARMAGGIPLRPHEVCMEDVCRRIISELEPAHPECCVRLEVDGESRGIWDEERLGQVLSNLLGNALQHSPEGSSVRVRLAAKDSLFQRVEVHNGGPPIPESLRPRLFSPFHGVPPEPGQPKPKHQGLGLGLYIVSQIVTAHGGWLDVASSADTGTCFSVTLPRVTRPLGGPPGKTA
Protein: Prominin, isoform D (B7YZQ3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDQRNLTLPTPAATTIMSSSSAAMSAGFASLGGPTTSALTGSTIALATTTTTAPPTTTPATFFTYSIPGMDIAPGPFIFTYVSEFLSLITPEELPLDSIRDVLHKNTSLLDFASNAIKIESGFIALMSVFAILALVPLIATCAWCCGRRSTQEEVDHIRNAPCHIRDESLEESLRCRKSAGLVTLWVVFILLTLSDFSIFYANSRLSAGIEMTPEMVKSAVHDVEVFLKDTHLQIKQKLDNGFHVSVERVVKDLEDVDVLLGEPIQAEISAHTGLELAYDSLTTLSLANAELIYRVLMLQETVGRALKLSQEAAARMEELQIQLSVLQRQCTYRDRPLCDTLRIRSFEENGVVDALKTLQEDQSIFRMRYLGEIEFGATVKNLTSEVGVSRSIFSNFPQQVKHDTAYERNYTLEQLASIRHRTTANAQQLTSTVNGLLRRLEDTWSSLQPAYNELKEWADAYWSVGWIAGTVIVWVMLFMLMSYCCFLCESNAKSGVVFFIAVMLICLASICLTIFGVFSLAVGGNAEVFVCRSLYDEDYNMLGKLLDKPGYAYAREPQTGIIGELLRPVGVNRSVVNVGLGQALRGCEQNQASYNVFQLDAFVNTSKIADLRQFPKVSTAIDAISVSGRTLLSLTQSVQNILDNMLQTSSFNLTTYRSSVGAPTPEKDLATFIDQMQRVALQIQDVATSSRMTTLGSRSKRLQASILQPLENLQNEILYHLTALELQRDPWAKQVNQTLNHLKSIQSYLENKAGEICHNMTRDYRDRLKAYLTTSKATMESQLGDTTTKCRPFYDTFDASRTFLCRNMVDFINGLTFFIFLTLLLWAIGTPVGLNLITVQTRLNVMQAAQARSKGRHRRSDRSPEHEQRSGSRGRKKQRTSSSATSGRSGKRDQSRERSTSSTARPKPPLRRTATEETLDLADEESTPSRQQQQQPPPQRRQESDRERVRERDQRSRERELSRGRDASAMNTPVRSRSRQQLRHDPEDDNWGSSSGPSRANSRERDRESSQTRKILNIWQSRNKAKTPLRRQGTEEFDFEDAHDDRGWQAQTQNQVQNQSRAHNQSSVSPEQRPDPRSHRSNLRTKPKLRSTNADRASSEAIRRPITPVLSVNSDIPAAIPMPRTPMRLKSKVSLTARAVQDIVNKRNQRLQRTGTDEFDLDDSDAYGAGGHLDADVAAARRTPPRGAPPPPPPPAAGLNSDRTVRWNEDETEDFDFEEVDAPKSPMYLSHNLQ
Protein: LD40944p (Q7K4G8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform B
- RE17222p
Sequence:
MEADITPLAETNGEQRQNPQESAQNQEQPQPRQDLAGKSVGSADDGVSGTVGQIMDYLEDDAGATADQDAEMGEAEYLDGEMPQEDESETPQTEKANEGCQESSNKKDLQESAAKDDFSKEKSGEDGEKDTDKEKKATHLHEDNNDDAEKDGDEADAEDEDDVEKPEDEDGTEEGDEAIEEDEDALDEDEDPNEEVEEIEPDFETGTDAEGELITGDEPGDLADVPIRERKKEEPVDEDQCRVCTSKEELVCLFKKQIDATPADMLLVICPNVSILPKDFMPQFICTKCMGSLTIAIQLRKQLETTDQELRKRLSRSKNKVRRPRGYVVIDAPVTDSSEDEDELDDEFKVSDVAGTTSADSDSADSDDSEKEKKKPGPRGRPRKKPLKRGTDSDGEPSSAQKKKYQPSSTASVGPFECPNCDLTFSRKQSYVLHRKTHERIEHACPICGKKFKVEWAYKTHMQRHEQERAHFRCELCPKIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQAVGCQRHKEDSVRIKEEQSRFKQESRSKDDRHHGNNSSKRRPGEGRDLFKAVAPPTTTYWSDSFSD
Protein: Equilibrative nucleoside transporter 3 (hENT3) (Solute carrier family 29 member 3) (Q9BZD2)
Organism: Homo sapiens (Human)
Function: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:15701636, ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:15701636}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000269|PubMed:19164483}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:19164483}; Multi-pass membrane protein {ECO:0000305}. Note=Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes (PubMed:15701636). Detected at the cell surface only in certain placental cells (PubMed:19164483). {ECO:0000269|PubMed:15701636, ECO:0000269|PubMed:19164483}.
Interaction partners:
- Equilibrative nucleoside transporter 2
- Equilibrative nucleoside transporter 1
- Solute carrier family 28 member 3
- Sodium/nucleoside cotransporter 1
- Sodium/nucleoside cotransporter 2
- CD63 antigen
Sequence:
MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSLGIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLVANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTSSWTRGFFAVTIVCMVILSGASTVFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATVFLVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRPILKKTASLGFCVTYVFFITSLIYPAICTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADLCGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSSLLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI
Protein: Shikimate kinase 1 (SK 1) (EC 2.7.1.71) (Shikimate kinase I) (SKI) (P0A6D7)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- 3-dehydroquinate synthase
- Quinate/shikimate dehydrogenase
- Shikimate dehydrogenase
- 3-phosphoshikimate 1-carboxyvinyltransferase
- 3-dehydroquinate dehydratase
- Chorismate synthase
- Shikimate kinase 2
- Bifunctional chorismate mutase/prephenate dehydratase
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
- Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
Sequence:
MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADVGWVFDLEGEEGFRDREEKVINELTEKQGIVLATGGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLHVETPPREVLEALANERNPLYEEIADVTIRTDDQSAKVVANQIIHMLESN
Protein: Large ribosomal subunit protein eL27B (60S ribosomal protein L27-B) (P0C2H7)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein eL34A
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL29A
- Large ribosomal subunit protein eL37B
- Large ribosomal subunit protein eL37A
- Large ribosomal subunit protein uL22A
- Large ribosomal subunit protein uL22B
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL30
- Ribosome biogenesis protein RLP7
Sequence:
MAKFLKAGKVAVVVRGRYAGKKVVIVKPHDEGSKSHPFGHALVAGIERYPSKVTKKHGAKKVAKRTKIKPFIKVVNYNHLLPTRYTLDVEAFKSVVSTETFEQPSQREEAKKVVKKAFEERHQAGKNQWFFSKLRF
Protein: Right handed beta helix domain-containing protein (Q581R3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPPKRAGSRKRKEVLPDPQTLPSGTCNYYIGEWFVNKEIDSLSDISHSVVEAHTKSNGEVSVLPRTVVLIPPATLGDVNTHYAVEVADNLRVESIPRSAVEPKPKAIPVEGEESFDPLSTREKKEEEGDSVVPDDTLPSAAAVQKVGSSEAAAEVVIQGTVHIEGIVPRIVITPDLPEPPVVPKKKKSDARKNSKRKEEEQKRLAEEARIYEEKVNAAVAAAREEEEYRMQFAHPERWPNVQFANMTFNGQVIVAHAHVKFRNCCFTSRSKDTTQLLVAQYCKVECERCTFDQPQKGSVYGWPMSNIILTECYFKGASSSRDGCTLPVANACESRPTCVGLHTDACKITVKDCEFSALGTGVIMRGTFPGSCAGQPAMSIKNCKFYGIYAAGIVLDSVNGVELAGNKVDECEYYALDCVKGEGIRVYQNTFLSKIRVQKGAHARFLNNETGTIPFTVEEVENPNWQPVY
Protein: OX-2 membrane glycoprotein (CD antigen CD200) (P41217)
Organism: Homo sapiens (Human)
Function: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Cell surface glycoprotein CD200 receptor 1
- Tyrosine-protein phosphatase non-receptor type substrate 1
- CX3C chemokine receptor 1
- Receptor-type tyrosine-protein phosphatase C
- Fractalkine
- B- and T-lymphocyte attenuator
- Triggering receptor expressed on myeloid cells 2
- Leukocyte surface antigen CD47
- B-lymphocyte antigen CD19
- T-cell surface glycoprotein CD8 alpha chain
Sequence:
MERLVIRMPFSHLSTYSLVWVMAAVVLCTAQVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVNKGYWFSVPLLLSIVSLVILLVLISILLYWKRHRNQDRGELSQGVQKMT
Protein: UspA domain-containing protein (A0A0H3LA33)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Interaction partners:
Sequence:
MSKPRKQHGVVVGVDGSLESDAAACWGATDAAMRNIPLTVVHVVNADVATWPPMPYPETWGVWQEDEGRQIVANAVKLAKEAVGADRKLSVKSELVFSTPVPTMVEISNEAEMVVLGSSGRGALARGLLGSVSSSLVRRAGCPVAVIHSDDAVIPDPQHAPVLVGIDGSPVSELATAVAFDEASRRGVELIAVHAWSDVEVVELPGLDFSAVQQEAELSLAERLAGWQERYPDVPVSRVVVCDRPARKLVQKSASAQLVVVGSHGRGGLTGMLLGSVSNAVLHAARVPVIVARQS