wanglab/gogpt-training-data huggingface dataset:
Protein: Phospholipid-inositol phosphatase (PLIP) (EC 3.1.3.-) (5-Phosphatidylinositol phosphatase) (Q86IG3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Exhibits phosphatidylinositol-phosphate phosphatase activity. Has a preference for phosphatidylinositol 5-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)) in vitro. May be involved in membrane trafficking by dephosphorylating phosphatidylinositides.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12878591}.
Interaction partners:
Sequence:
MNENEGIIIENINNDSGSTYLMNILGILIPIKIVVTIYLFSKARLPVGFARYFGRLYHFMTNPIRLGLQIAGLRGPFISQLDDNVYLGAMPMGSDVTLLFYKYKINSIVNLCDEYQGPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQYYSSYCLNSNINSTTSI
Protein: Tubulin-tyrsoine ligase-like protein, putative (EC 6.3.2.-) (Q384Y9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRNMMEPVIARPRKQVATAVLISETLSSTLHVREESMGGAAGTGHISEDGGSKVGVLRADAPLSVNPSRRRCSGSMARPRLDAGTLGSPFAKSTKKTIRELIDMSGTSVKEEVVEKQDKTVIIQHSTIRKPVGIDMRGGSISTPKKINVSPKPISPIRRGWHSAGSAGKVGERTPCETTRERDSSASRSPVHRRSAGSAMSRLESNVSTPNSSKNSTVSRGAIGAFGPFSPLSSLRLTDLERPGTRSTPLNSLTKTPGSRRARPQYKIVNLALCKYPLLRIIAQENGFKIQELEDDLERNNFNIVWSDTVLPLTRLVRLANWQRTNHFPSMYLLCRKGHLGITLGRMRKVMPSHYIFYPRTWSLRSERHQFARFLMALRSKKLSKFFIMKPNSGCQGRGIMITRDPLNAVEDLDNYIVQEYITRPLLLEGRKFDLRVYVLLTSIRAPSIFLFNDGLVRQCAELYERPTDANVKNTCKHLTNYAVNKHNPEYVFNDDPANCNVGNKRNFKFFNEWLESCGKSVEQFWARVAHVICKTILVAQPQIANVYNSCFPRHNSGYSCFEVLGFDILVDNKMKPWLMEVNHTPSLVTDTPLDYEVKHALISEVWDILDVKVTDRKRDERKERDEFIQRMMRPPVNTANTHTTTAQKRQNSGDTANGVATNGSSSNANQASNATGAGSSSTQDGMTEWEKTVEGRRAAEDSRLRNFRRIYPSDNSDWQALYDMILAQARALCSGPLVPGADDRLRRVDTTSVAGSLQPSQSGGSTAERSGRGGAPEAIGEGSVQSAAGVLRLGQRQRPQEASPSYRKTRRVTGTTTPTPTPGAQVQKTPLELNQGTTVPQAPLLRPPQLPPSMELANVVVHQKERRPTLMNRVCLPDSTLAEKVVTVTTGRESDGHGRGATADLGVGLRKTHVVSARILSPVGKASPGLITTSPPESPTADRIEALRSLQKRLDQEAECEISTTQENAEREDSFHLDE
Protein: Putrescine N-methyltransferase 3 (A0A1U7VVY4)
Organism: Nicotiana sylvestris (Wood tobacco) (South American tobacco)
Interaction partners:
- ornithine decarboxylase
- ornithine decarboxylase
- ornithine decarboxylase
- N-carbamoylputrescine amidase
- Putrescine N-methyltransferase 4 isoform X1
- Putrescine N-methyltransferase
- LOW QUALITY PROTEIN: spermine synthase
- Probable polyamine oxidase 4
- Probable polyamine oxidase 4
- Probable polyamine oxidase 2 isoform X1
Sequence:
MEVISTNTNGSTIFKNGAIPMNGYQNGTSKHQNGHQNGTSEHRNGHQNGISEHQNGHQNGTSEHQNGHQNGTISHDNGNELQLLGSSNSIKPGWFSEFSALWPGEAFSLKVEKLLFQGKSDYQDVMLFESATYGKVLTLDGAIQHTENGGFPYTEMIVHLPLGSIPNPKKVLIIGGGIGFTLFEMLRYPTIEKIDIVEIDDVVVDVSRKFFPYLAANFSDPRVTLVLGDGAAFVKAAQAGYYDAIIVDSSDPIGPAKDLFERPFFEAVAKALRPGGVVCTQAESIWLHMHIIKQIIANCRQVFKGSVNYAWTTVPTYPTGVIGYMLCSTEGPEVDFKNPVNPIDKETTQVKSKLAPLKFYNSDIHKAAFILPSFARSMIES
Protein: Neuropeptide-like peptides nlp-40 [Cleaved into: Peptide P1 (P1); Peptide P2 (P2); Peptide P3 (P3); Peptide P4 (P4)] (Q9N4D8)
Organism: Caenorhabditis elegans
Function: Neuropeptide ligand for the G-protein coupled receptor aex-2. Activates and regulates the rhythmic calcium influx in DVB GABergic neurons during the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds.
Subcellular location: Secreted {ECO:0000305|PubMed:23583549}. Cytoplasmic vesicle {ECO:0000269|PubMed:23583549}. Note=Secreted by intestinal cells and subsequently endocytosed by coelomocytes. Co-localizes with snt-2 on the cell surface. {ECO:0000269|PubMed:23583549}.
Interaction partners:
- G-protein coupled receptor aex-2
- C2 domain-containing protein aex-1
- Saposin B-type domain-containing protein
Sequence:
MKLVILLSFVATVAVFAAPSAPAGLEEKLRALQEQLYSLEKENGVDVKQKEQPAAADTFLGFVPQKRMVAWQPMKRSMINEDSRAPLLHAIEARLAEVLRAGERLGVNPEEVLADLRARNQFQ
Protein: Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2) (P07954)
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable).
Subcellular location: [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:27037871}.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm, cytosol {ECO:0000269|PubMed:20231875, ECO:0000269|PubMed:22509282, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:27037871}. Nucleus {ECO:0000269|PubMed:20231875, ECO:0000269|PubMed:26237645}. Chromosome {ECO:0000269|PubMed:26237645}. Note=Translocates to the nucleus in response to DNA damage: localizes to DNA double-strand breaks (DSBs) following phosphorylation by PRKDC. {ECO:0000269|PubMed:26237645}.
Interaction partners:
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Malate dehydrogenase, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Citrate synthase, mitochondrial
- NADP-dependent malic enzyme
- NAD-dependent malic enzyme, mitochondrial
- NADP-dependent malic enzyme, mitochondrial
- Aspartate aminotransferase, mitochondrial
Sequence:
MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK
Protein: Proline rich 13 (F8VZP4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGYLDSIGWRTHLNMWNPNAGQPGPNPYPPNIGCPGGSNPAHPPPINPPFPPGPCPPPPGAPHGNPAFPPGGPPHPVPQPGYPGCQPLGPYPPPYPPPAPGIPPVNPLAPGMVGPAVIVDKKMQKKMKKAHKKMHKHQKHHKYHKHGKHSSSSSSSSSSDSD
Protein: Kynurenine aminotransferase (EC 2.6.1.-) (EC 2.6.1.63) (EC 2.6.1.7) (AeKAT) (Q17CS8)
Organism: Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Also catalyzes the irreversible transamination of several amino acids including cysteine, tyrosine, glutamine, methionine, histidine and phenylalanine. Can use various keto-acids as the amino group acceptor.
Subcellular location: Mitochondrion {ECO:0000255}.
Interaction partners:
- Aspartate aminotransferase
- Kynurenine 3-monooxygenase
- Kynurenine formamidase
- Aspartate aminotransferase
- 5-methyltetrahydrofolate:homocysteine methyltransferase
- thioredoxin-disulfide reductase
- Cystathionine beta-synthase
- Cystathionine beta-synthase
- Adenosylhomocysteinase
- Adenosylhomocysteinase
Sequence:
MMFLRNHNSVGGAIRTAVVLQDLQFIVSNKSSALTGAVSSVHRQQIRTMSSTSNETMHNKFDLPKRYQGSTKSVWVEYIQLAAQYKPLNLGQGFPDYHAPKYALDALAAAANSPDPLANQYTRGFGHPRLVQALSKLYSQLVDRTINPMTEVLVTVGAYEALYATIQGHVDEGDEVIIIEPFFDCYEPMVKAAGGIPRFIPLKPNKTGGTISSADWVLDNNELEALFNEKTKMIIINTPHNPLGKVMDRAELEVVANLCKKWNVLCVSDEVYEHMVFEPFEHIRICTLPGMWERTITIGSAGKTFSLTGWKIGWAYGPEALLKNLQMVHQNCVYTCATPIQEAIAVGFETELKRLKSPECYFNSISGELMAKRDYMASFLAEVGMNPTVPQGGYFMVADWSSLDSKVDLTQETDARKDYRFTKWMTKSVGLQGIPPSAFYSEPNKHLGEDFVRYCFFKKDENLQKAAEILRKWKGSS
Protein: Protein slowmo (Q9V3U9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required to regulate peristaltic movement and also for germline proliferation in males and females.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14673704}.
Interaction partners:
- AT19138p
- TP53-regulated inhibitor of apoptosis 1
- Protein preli-like
- Glutaredoxin domain-containing cysteine-rich protein CG12206
Sequence:
MKIWTSEHIFNHPWETVTQAAWRKYPNPMTPSIIGTDVVERRVVDGVLHTHRLVQSKWYFPKWTHALIGTAKTCFASERSTVDPERKQMVLKTNNLTFCRNISVDEVLYYEPHPSDASKTLLKQEATVTVFGVPLSHYMEDLLTSTISTNAGKGRQGLEWVIGLINTEVKGIARGTDELLHNTRRSIDEVTESARKSMDEISAQAAKAAKAMHIT
Protein: Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (A4QNV7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MEGENTLITENTSLYMNISAGLNASSSVSLSVSEYSDAEVVLISILIGILVLVIVFGNALVISAIVRFQRLQTVTNYFISSLACADLVMGLMVVPFGACYILLNTWHFGNFFCEFWTATDVLCVTASIETLCVIALDRYIAIMWPLRYQSMLTKRKACGMVIGVWAVAALISFLPIHMEWWVSDEPEALSCLEEPTCCDFNTNAAYAVTSSIISFYIPLVIMAFVYSRVFQEARRQLQKIDRIEGRIRTQSLSTQEGNEIKNRRTKFCIKDHKALKTLGIIMGTFTLCWLPFFVLNVVAAIWKMDNIMLPFRILNWIGYANSAFNPLIYCRSPEFRCAFQEILCWRPSHLRSTRSKKGYLYSGHSWKVHTKTTRPREPSPACETEIGAECLTAGTKNKNGNYNKTVTSI
Protein: 9-cis-epoxycarotenoid dioxygenase NCED6, chloroplastic (AtNCED6) (EC 1.13.11.51) (Q9LRM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity. Catalyzes the first step of abscisic-acid biosynthesis from carotenoids. Contributes probably to abscisic acid synthesis for the induction of seed dormancy.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:12834401}. Note=Partially bound to the thylakoid.
Interaction partners:
- Xanthoxin dehydrogenase
- Zeaxanthin epoxidase, chloroplastic
- Abscisic acid 8'-hydroxylase 2
- Abscisic-aldehyde oxidase
- Phytoene synthase 1, chloroplastic
- B3 domain-containing transcription factor ABI3
- Abscisic acid 8'-hydroxylase 1
- Protein ABSCISIC ACID-INSENSITIVE 5
- Gibberellin 3-beta-dioxygenase 1
- Ethylene-responsive transcription factor ABI4
Sequence:
MQHSLRSDLLPTKTSPRSHLLPQPKNANISRRILINPFKIPTLPDLTSPVPSPVKLKPTYPNLNLLQKLAATMLDKIESSIVIPMEQNRPLPKPTDPAVQLSGNFAPVNECPVQNGLEVVGQIPSCLKGVYIRNGANPMFPPLAGHHLFDGDGMIHAVSIGFDNQVSYSCRYTKTNRLVQETALGRSVFPKPIGELHGHSGLARLALFTARAGIGLVDGTRGMGVANAGVVFFNGRLLAMSEDDLPYQVKIDGQGDLETIGRFGFDDQIDSSVIAHPKVDATTGDLHTLSYNVLKKPHLRYLKFNTCGKKTRDVEITLPEPTMIHDFAITENFVVIPDQQMVFKLSEMIRGGSPVIYVKEKMARFGVLSKQDLTGSDINWVDVPDCFCFHLWNAWEERTEEGDPVIVVIGSCMSPPDTIFSESGEPTRVELSEIRLNMRTKESNRKVIVTGVNLEAGHINRSYVGRKSQFVYIAIADPWPKCSGIAKVDIQNGTVSEFNYGPSRFGGEPCFVPEGEGEEDKGYVMGFVRDEEKDESEFVVVDATDMKQVAAVRLPERVPYGFHGTFVSENQLKEQVF
Protein: DNA repair protein RAD52 homolog isoform X1 (RAD52 homolog, DNA repair protein) (F1QXE3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- DNA repair protein RAD51 homolog
- Replication protein A 70 kDa DNA-binding subunit
- FA complementation group M.
- Helicase ATP-binding domain-containing protein.
- WRN RecQ-like helicase.
- Structure-specific endonuclease subunit MUS81
- DNA helicase
- DNA ligase
- X-ray repair cross-complementing protein 5
- Exonuclease 1
Sequence:
MDYSSGRQEEKKPHTTNTCFGQYSYSAEEYQAVQNALRQKLGPEYISTRQAGGGQKVCYIEGHKVISLANEMFGYNGWSHSISQQNVDFVDLINGKFYVGVSAFIKVQLKDGSFHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALKCFGNALGNCILNKEYLIAINKIPKQPPPPLDADKTKRSDLEPSVEKARFDSLAQTNSRQFTKLEKSANIPIEQMGNLPVREGHESATGPRTSLTNTTALPGNTTTHQDTENRPSNTSRSASDTTELSSSDPLLDSKQQRKLRQQQLQQKFRQEMEAKKLLQEKKDQQPTLHIKQEQGVGPVNHSTPNGHLVTKQEQYMADDPEMWDFTLDGIDMLDDPSTRSTDPPRPSTPNQHTMTTRSKTPQRPQCLRPPAQPQGHFRSSTAGGPSSPYRHGQMMKKRRLDT
Protein: Hephaestus, isoform Y (A0A0B4K6W9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein K, isoform C
- Heterogeneous nuclear ribonucleoprotein A1
- Smooth, isoform T
- LD40489p
- Uncharacterized protein, isoform C
Sequence:
MMSCPIPMPMPISSLHKSEFEPVNIGVKQMQLLHAPASTHPHPHPHQHPQHSAASAAAYQAMQVHQQQHQQQQQAAVFHHQVAAIAAQQQQQQQQAQVQHQQQMQQQFHYQAQAQAQAQAMLQTYMQLQVNSAVGVSTAPATPTKPVAAQIPGAISGPIAGPVPVSVPTQFFTAPSTPLTIIPAAAVASSAMFATAATPTSAATTPTNNVNNTVNLSAVSRTTTTTTKKQPQAVADAVLSAVGGNVGTAVGGGTISSLLGPEPLPIMPHHLPLASVRGCSSASSGCSSASSDCSMPSPTSLHLSSPKKVRIDEQYIYKLNYLRGSDELLSQAAVMAPASDNNNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSVNGLGAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGYSNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSKSNI
Protein: Meiotically up-regulated gene 35 protein (O94435)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MTNERHDELACLGIFPLKNPKQLDGVVTPILQLRVKFLAPTDRWWEGLVINKDLSKEESEELWKFLQSFDPRSAKFVGRGTPEDHVISYLFEAGKYEFEVFFYQKDHSLKLMGLYDKTQKQLLRRDSSGDLTSTDKERDVSPVSHSEKPYWDRYDLDQPSNQDVEESRNLVQEPKHRSKKYDRLGLDELVMEQTASLWKICSRNGMSVDEFLRFIRMGLESNFQHSNQVIPTHF
Protein: Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) (P28562)
Organism: Homo sapiens (Human)
Function: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q91790}.
Interaction partners:
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 8
- Mitogen-activated protein kinase 11
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 9
- Protein c-Fos
- Mitogen-activated protein kinase 13
- mRNA decay activator protein ZFP36
Sequence:
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
Protein: RNA helicase (EC 3.6.4.13) (A7LCX1)
Organism: Sus scrofa (Pig)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSSDGYSADQNFCYLISCFRARVKRYIQVEPVLDYLTFLPAEVKEQIQRAVATTGNINAAELLLNTLEKGVWPPGWTRMFVQALRETGNSLAARYVNPDLTDLPSPSFESSHDECLQLLNLLQPTVVDKLLVTDVLDKCVEEQLLTGEDRNRVSAAENDGNESGVRELLKRIVQKENWFSTFLTVLRQTGNDALARELTGTDCCESNAESDDLLGENGPEVQEPLLLATDQPSLDVSDIEKSSLESSFADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEETVAQRASPEPELHLRPYQLEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKEASEPGKVIVLVNKVPLVEQLFRKEFEPFLKKWYRVTRLSGDTQLKITFPEVVKSCDVIISTAQILENSLLNSEEGEDPGVQLSDFSLIIIDECHHTNKEAVYNNIMRRYLKQKLKNNKLKKEEKPVIPLPQILGLTASPGVGGAKKQAKAEEHILKICANLDAFTIKTVKKNINQLKDQIKEPCKKFVIADDTREDLFKDRLLEIMTNIQTFCQISPMSDFGTQPYEQWLIQMEKKAARDGNRKDRVCAEHLKKYNEALQINDTIRRIDAYNHLKTFYNDEKEKKFEVLEDDSDDNGDDSDNDEDENDEKKPSKLDESDIFLMTLFLRNKKILKKLAENPEYENEKLTKLRNTIMEHFTRTEESARGIIFTKTRQSAYALSQWITDNKKFAEVGVKAHHLIGAGHSSEFKPMTQNEQREVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAQSGSGVIERETVNDFREKMMYKAIDRVQNMKPEEYAHKILELQMQSIMEKKMKIKRSIAKQCKDNPSLISFLCKNCSVLACSGEDIHIIEKMHHVNMTPEFKNLYIVRGNKALQTKFADYQTNGEIICKKCGQAWGTMMVHKGLDLPCLKIKNYVVAFKNNLFKKQYKKWVELPITFPDLNYSEYCLSSDED
Protein: Islet amyloid polypeptide (Amylin) (D3Y4D2)
Organism: Sus scrofa (Pig)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
KCNMATCATQHLANFLDRSRNNLGTIFSPTKVGSNTY
Protein: Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) (Q9Y617)
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
Interaction partners:
- Phosphoserine phosphatase
- D-3-phosphoglycerate dehydrogenase
- C-terminal-binding protein 1
- C-terminal-binding protein 2
- Serine hydroxymethyltransferase, mitochondrial
- Glyoxylate reductase/hydroxypyruvate reductase
- Serine hydroxymethyltransferase, cytosolic
- Asparagine synthetase
- Delta-1-pyrroline-5-carboxylate synthase
- Bifunctional epoxide hydrolase 2
Sequence:
MDAPRQVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSHRSSDFAKIINNTENLVRELLAVPDNYKVIFLQGGGCGQFSAVPLNLIGLKAGRCADYVVTGAWSAKAAEEAKKFGTINIVHPKLGSYTKIPDPSTWNLNPDASYVYYCANETVHGVEFDFIPDVKGAVLVCDMSSNFLSKPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFALRECPSVLEYKVQAGNSSLYNTPPCFSIYVMGLVLEWIKNNGGAAAMEKLSSIKSQTIYEIIDNSQGFYVCPVEPQNRSKMNIPFRIGNAKGDDALEKRFLDKALELNMLSLKGHRSVGGIRASLYNAVTIEDVQKLAAFMKKFLEMHQL
Protein: Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) (Q8CG73)
Organism: Mus musculus (Mouse)
Function: Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins. Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21565611}. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26150391}. Cell junction, tight junction {ECO:0000269|PubMed:21565611}. Note=In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. Localizes to the ciliary transition zone. {ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22927466, ECO:0000269|PubMed:26150391}.
Interaction partners:
- Nephrocystin-4
- Nephrocystin-1
- Centrosomal protein of 290 kDa
- X-linked retinitis pigmentosa GTPase regulator
- 26S proteasome non-ATPase regulatory subunit 2
- Meckelin
- Jouberin
- Transmembrane protein 231
- IQ calmodulin-binding motif-containing protein 1
- Nephrocystin-3
Sequence:
MSGPSDETAGDLPVKDTGLNLFGVGGLQETSTARTVKTRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELERQNEVLKNRLISAKQQLQVQGHRQTSYSRVQARVNTGRRRASASAGSQECPGKGLRFQNVDEAETVQPTLTKYSNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLKRKENEIELSLLQLREQQATDQRSNIRDNVETIKLHKQLVEKSNALSVIEGKFIQLQEKQRTLRISHDALMANGDELNKQLKEQRLKCCSLEKQLHSVRFSERRVEELQDRINDLEKERELLKENYDKLYNSAFSAAHEEQWKLKEQQMKVQIAQLETALKSDLTDKTEVLDKLKTERDQNEKLVQENRDLQLQCLQQKQRLHELQSRLKFFNQESDINADDLSEALLLIKAQKEQKNGDLSFLEKVDSKINKDLDRSMKELQATHAETVQELEKTRNMLIMQHKINKDYQMEVETVTQKMENLQQDYELKVEQYVHLLDIRAARIQKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLRASGDKELVTFCTYAFYDFELQTTPIVRGLYPEYNFTSQYLVHVNDLFLQYIQKNTVTLELHQAHSTDYETIAACQLRFHEILEKSGRIFCTTSLVGTKGDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKKPEKMQLSSQQAATTAQISPAESTDGNLNELHVTVKCCTGLQSRASYLQPHAYVVYKFFDFPDHDTAIVPSSNDPQFDDHMCFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYMGKVNVPLISLAHDKCISGIFELMDKEKHAAGTIQVILKWKFTYLPPSGSITTEDLGKFVCREEPEAVQRLPPKSSDVTSVVAPKPKPRQRLTFVDKKVSFADTISHPSPETSPPPKDIKDSSPEVGPKPENGLSAVAYPSKESGVAKVEENVGEMQQGKEDDISFLSEGQLASGSVASSEDETEITEELEPEDEDRSASDSDDCIIPSSVSTNTKQPSEEIRIEIIALNLNDSQITREDTIQRLFIECRFYSLPAEETPMSLPKPQSGQWVYYNYSNVIYLDKENNPAVRDILKAILQRRELPHRSVRFTVVSDPPEDEQDLECEDIGVAHVDLADLFQKGRDIIEQDIDVLDARTDGGTIGKLKVTVEALHALRSVYEQNRKDLEA
Protein: Transducin/WD40 repeat-like superfamily protein (Q9M1E5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MARPRRRNTEIGDGFTEIFNREIGFSHPITISRRISASEGRVKKLDLYGKLNGHEGCVNAVEFNSTGDVLVSGSDDRQIMLWNWLSGSRKLSYPSGHCENVFQTKFIPFTDDRTIITSGADGQVRLGQILENGKVETKRLGRHHGRVYKLAVLPGDPNVFYSCGEDGFVQHFDIRSNSATMVLYSSPFTQGCRRHHSSSRIRLNSIAIDPRNSYYLAVGGSDEYARVYDTRRVQLAPVCRHVLPDAPVNTFCPRHLRETNSVHITGLAYSKAGELLVSYNDELIYLFEKNMGYGSSPVSVSPEKLQEMEEPQVYIGHRNAQTVKGVNFFGPNDEYVTSGSDCGHIFIWKKKGGKLVRAMVGDRRVVNQLESHPHIPLLASCGIEKSVKLWTPMSNDVLSLPEKIDKVMELNRVGREDQSRVTLTPDVIMHVLRLQRRQTSAFTERRYVSTDIGSDEGNDARFIASLVANDDESSDRECTVS
Protein: Cathepsin B (EC 3.4.22.1) (B5X4P4)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
- NACHT, LRR and PYD domains-containing protein 3-like isoform X2
- NACHT, LRR and PYD domains-containing protein 3-like
- Cathepsin B
- NACHT, LRR and PYD domains-containing protein 3-like
- Cathepsin B
- Cathepsin D
- Cathepsin D
- Cathepsin D-like
- Cathepsin D
- Cathepsin D
Sequence:
MWCALFLVLGSGLSISWARPHLPPLSHEMVNFINKANTTWKAGHNFHNVDYSYVKRLCGTLLKGPKLSTMVQYTEDMELPKNFDPRLQWPNCPTLKEVRDQGSCGSCWAFGAAEAISDRVCIHSNAKVSVEISSEDLLSCCESCGMGCNGGYPSAACDFWTKEGLVSGGLYDSHIGCRPYSIPPCEHHVNGTRPPCKGEEGDTPQCTNQCEPGYTPGYKQDKHFGKRSYSVPSDEKEIMKELYKNGPVEGAFTVYEDFLLYKSGVYRHVSGSAVGGHAIKVLGWGEEGGIPYWLAANSWNTDWGENGFFKIVRGEDHCGIESEMVAGIPL
Protein: Branched-chain amino acid ABC transporter, ATP-binding protein (Q5LSR0)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Interaction partners:
- Branched-chain amino acid ABC transporter, ATP-binding protein, putative
- Branched-chain amino acid ABC transporter, permease protein
- Branched-chain amino acid ABC transporter, permease protein
- Branched-chain amino acid ABC transporter, periplasmic substrate-binding protein
- Branched-chain amino acid ABC transporter, permease protein
- Branched-chain amino acid ABC transporter, permease protein
- Regulatory protein, putative
- Branched-chain amino acid ABC transporter, ATP-binding protein
- Branched-chain amino acid ABC transporter, permease/ATP-binding protein
- Branched-chain amino acid ABC transporter, permease protein
Sequence:
MLKLQDLTLHYGHSQILHGISMEAALGEITCVMGTNGVGKTSLIKAISGTHPRSGGEMILDGEPLGVLPAHQLAHKGVAYVPQGREIFPLLTVRENLETGFGCLPASDRLIPDEIFELFPVLKQMQNRRGGDLSGGQQQQLAIARALITRPRLLLLDEPTEGIQPNIIQQIGQVIRHLRSQGTMAIILVEQYFEFAYDLADRFVVLRRGEVLVAGRKGELSKADVLKGVSV
Protein: Epithelial sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Amiloride-sensitive sodium channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) (Q9WU39)
Organism: Mus musculus (Mouse)
Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subcellular location: Apical cell membrane {ECO:0000305|PubMed:10409305}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51170}.
Interaction partners:
- Epithelial sodium channel subunit beta
- E3 ubiquitin-protein ligase NEDD4-like
- Epithelial sodium channel subunit alpha
- E3 ubiquitin-protein ligase NEDD4
- Protein unc-80 homolog
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Cystic fibrosis transmembrane conductance regulator
- Serine/threonine-protein kinase Sgk1
- Sodium/hydrogen exchanger 3
- Sodium channel protein type 5 subunit alpha
Sequence:
MAPGEKIKAKIKKNLPVRGPQAPTIKDLMHWYCLNTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKDVLDSTPRKRREAGSMRSTWEGTPPRFLNLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNRENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLVHQQNEYPFIEDVGTEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKDWWARRRTPPSTETPSSQQGQDNPALDTDDDLPTFTSAMRLPPAPEAPVPGTPPPRYNTLRLDSAFSSQLTDTQLTNEF