wanglab/gogpt-training-data huggingface dataset:
Protein: Alpha-2B adrenergic receptor (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR) (P30545)
Organism: Mus musculus (Mouse)
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P18089}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18089}. Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. {ECO:0000250|UniProtKB:P18089}.
Interaction partners:
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Alpha-2A adrenergic receptor
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
Sequence:
MSGPAMVHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPHPAAGGVPASAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPNWSALPRSVQDQKKGTSGATAEKGAEEDEEEVEECEPQTLPASPASVFNPPLQQPQTSRVLATLRGQVLLSKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRQWTQTGW
Protein: Proton-coupled zinc antiporter SLC30A2 (Solute carrier family 30 member 2) (Zinc transporter 2) (ZnT-2) (Q9BRI3)
Organism: Homo sapiens (Human)
Function: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity. Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells. By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution.
Subcellular location: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:19496757}; Multi-pass membrane protein {ECO:0000255}. Zymogen granule membrane {ECO:0000250|UniProtKB:Q2HJ10}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:19496757, ECO:0000269|PubMed:25808614}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:25808614, ECO:0000269|PubMed:30893306}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:21289295}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to lysosomes is induced by TNF-alpha. {ECO:0000269|PubMed:25808614}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:19496757}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter ZIP13
- Zinc transporter ZIP5
- Zinc transporter ZIP4
- Zinc transporter SLC39A7
- Zinc transporter ZIP12
- Zinc transporter ZIP10
- Zinc transporter ZIP1
- Metal cation symporter ZIP14
- Zinc transporter ZIP6
Sequence:
MEAKEKQHLLDARPAIRSYTGSLWQEGAGWIPLPRPGLDLQAIELAAQSNHHCHAQKGPDSHCDPKKGKAQRQLYVASAICLLFMIGEVVGGYLAHSLAVMTDAAHLLTDFASMLISLFSLWMSSRPATKTMNFGWQRAEILGALVSVLSIWVVTGVLVYLAVERLISGDYEIDGGTMLITSGCAVAVNIIMGLTLHQSGHGHSHGTTNQQEENPSVRAAFIHVIGDFMQSMGVLVAAYILYFKPEYKYVDPICTFVFSILVLGTTLTILRDVILVLMEGTPKGVDFTAVRDLLLSVEGVEALHSLHIWALTVAQPVLSVHIAIAQNTDAQAVLKTASSRLQGKFHFHTVTIQIEDYSEDMKDCQACQGPSD
Protein: Disease resistance RPP13-like protein 4 (Disease resistance protein ZAR1) (Protein HOPZ-ACTIVATED RESISTANCE 1) (AtZAR1) (Q38834)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: CC-NB-LRR receptor-like protein required for recognition of pathogenic bacteria type III effectors (T3E) such as Pseudomonas syringae HopZ1a and HopF2a and Xanthomonas campestris pv. campestris (Xcc) XopAC/AvrAC; this recognition requires ZED1-related kinases (e.g. PBL2, ZRK3 and ZED1/ZRK5). Confers allele-specific recognition and virulence attenuation of HopZ1a. Immunity mediated by RPP13L4/ZAR1 is independent of several genes required by other resistance protein signaling pathways such as NDR1 and RAR1. Together with ZED1/ZRK5, involved in the regulation of the ambient temperature-sensitive intersection of growth and immune response in the absence of pathogens.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30948527}. Nucleus {ECO:0000269|PubMed:28652264}. Note=Associates with the plasma membrane in the presence of the Xanthomonas campestris effector XopAC/AvrAC. {ECO:0000269|PubMed:30948527}.
Interaction partners:
- Probable serine/threonine-protein kinase PBL2
- Serine/threonine-protein kinase ZRK1
- Non-functional pseudokinase ZED1
- Toll/interleukin-1 receptor-like protein
- Probable disease resistance protein At5g45510
- Similarity to unknown protein
- RING-type E3 ubiquitin transferase
- Heavy metal-associated isoprenylated plant protein 33
- Heavy metal-associated isoprenylated plant protein 43
- AT5G12460.1
Sequence:
MVDAVVTVFLEKTLNILEEKGRTVSDYRKQLEDLQSELKYMQSFLKDAERQKRTNETLRTLVADLRELVYEAEDILVDCQLADGDDGNEQRSSNAWLSRLHPARVPLQYKKSKRLQEINERITKIKSQVEPYFEFITPSNVGRDNGTDRWSSPVYDHTQVVGLEGDKRKIKEWLFRSNDSQLLIMAFVGMGGLGKTTIAQEVFNDKEIEHRFERRIWVSVSQTFTEEQIMRSILRNLGDASVGDDIGTLLRKIQQYLLGKRYLIVMDDVWDKNLSWWDKIYQGLPRGQGGSVIVTTRSESVAKRVQARDDKTHRPELLSPDNSWLLFCNVAFAANDGTCERPELEDVGKEIVTKCKGLPLTIKAVGGLLLCKDHVYHEWRRIAEHFQDELRGNTSETDNVMSSLQLSYDELPSHLKSCILTLSLYPEDCVIPKQQLVHGWIGEGFVMWRNGRSATESGEDCFSGLTNRCLIEVVDKTYSGTIITCKIHDMVRDLVIDIAKKDSFSNPEGLNCRHLGISGNFDEKQIKVNHKLRGVVSTTKTGEVNKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQFPRSMEDLHNLQILDASYCQNLKQLQPCIVLFKKLLVLDMTNCGSLECFPKGIGSLVKLEVLLGFKPARSNNGCKLSEVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKLMSISINCYDSYGDDLITKIDALTPPHQLHELSLQFYPGKSSPSWLSPHKLPMLRYMSICSGNLVKMQEPFWGNENTHWRIEGLMLSSLSDLDMDWEVLQQSMPYLRTVTANWCPELESFAIEDVGFRGGVWMKTPLHRT
Protein: Histone acetyltransferase GCN5 (EC 2.3.1.48) (O76216)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSGGPSITIKSQPIDGNNTGNAAAQQQQQAANGAATAGASGAAGSAQNPGHGGAASGAGSVPAEGTRQNSLQRIQQRKQKVFNLPVPQKLAKLSMYSACQSEGCRCTGWKTPQENRHRDVESSYCPEFNEECRNTSCRHSLRSHIAHLDNISSSSMNELLGAIIDMENLFMSMQRVEDEDTKKVYQYLFRLLRQCVLTRQQAVIRGPLGDPPFETPCITKAVLSLVFYKYNHLSTPELQTMTEVAKTFLNFLNHYNFESPSTRRGDLTHEDASNYKINYTRWLVFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCVSQQLKKKCISERDRFPEDKRSIITLMPKFLETLRAELLKDDSPIWDTSYRPSNSFVIQQRKRNQEVASVPIGPSAASIGGNKRTSVGEPLHKRIKKEPTDRPSSENLDDLPADVVMRAMKSVSESKTTNKAEILFPVNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPREYISQLVFDTKHKTLALIKENQPIGGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDVKLARPVYAGYIKEYDSATLMHCELHPSIVNTQFIAVIRSQSEILKELIAQRHNEVQKVRPGLTCFKEGLPVIPVESIPGLREIGWKPQNRPARSSRPLEESTDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVPDYYDHIKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMRELGLWDK
Protein: Acid phosphatase (EC 3.1.3.2) (P08091)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Secreted, cell wall.
Interaction partners:
- Thiamine-repressible acid phosphatase pho4
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1
- Probable metabolite transport protein C1271.09
- Putative inorganic phosphate transporter C8E4.01c
- Uncharacterized transcriptional regulatory protein C27B12.11c
- Alkaline phosphatase
- Thiamine-repressible acid phosphatase SPBC21H7.03c
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2
- Probable thiamine biosynthetic bifunctional enzyme
- Probable acid phosphatase SPBC4.06
Sequence:
MFLQNLFLGFLAVVCANAQFAEFTAFDGKFDFKEHLTSRSPYHKPYFYGPSIDFPTTCKIKQVHTLQRHGSRNPTGGNAAFDAVGIANFQQRLLNGSVPIDYSVSGNPLSFVPTWTPVIEAANADALSSSGRVELFDMGRQFYERYHELFNASTYNIYTAAQQRVVDSALWYGYGMFGEDVHNFTNYILVSENATAGSNSLSSYNACPASDADDFTTPALEAWRNVYMPPIRQRLNPYFSNYNLTNDDILNLYGICSYEIALQDYSEFCKLFNSVDFLNFEYEGDLSFSYGMGNSVKWGSIFGGAYANSLANSLRSVENNTQQVFFAFTHDANIIPVETALGFFTDNTPENPLPTSYQVHSHSMKASEFVPFAGNLITELFQCEDSKYYVRHLVNEEVFPLSDCGFGPSNTSDGMCELYAYLNSPVRVNGTSNGIQNFDTLCNASAVAAVYPY
Protein: Odorant receptor 85a (Q9VHS4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Odorant receptor 85b
- Odorant receptor 47a
- Odorant receptor 56a
- Putative odorant receptor 92a
- Odorant receptor 67d
- Odorant receptor 67a
- Odorant receptor 10a
- Odorant receptor 43a
- Odorant receptor 88a
- Odorant receptor 65a
Sequence:
MIFKYIQEPVLGSLFRSRDSLIYLNRSIDQMGWRLPPRTKPYWWLYYIWTLVVIVLVFIFIPYGLIMTGIKEFKNFTTTDLFTYVQVPVNTNASIMKGIIVLFMRRRFSRAQKMMDAMDIRCTKMEEKVQVHRAAALCNRVVVIYHCIYFGYLSMALTGALVIGKTPFCLYNPLVNPDDHFYLATAIESVTMAGIILANLILDVYPIIYVVVLRIHMELLSERIKTLRTDVEKGDDQHYAELVECVKDHKLIVEYGNTLRPMISATMFIQLLSVGLLLGLAAVSMQFYNTVMERVVSGVYTIAILSQTFPFCYVCEQLSSDCESLTNTLFHSKWIGAERRYRTTMLYFIHNVQQSILFTAGGIFPICLNTNIKMAKFAFSVVTIVNEMDLAEKLRRE
Protein: RapA guanosine triphosphatase-activating protein B (Q54SS8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Mediates the deactivation of rap1 during multicellular development and is required for normal morphogenesis. Also required for the correct patterning of specific subtypes of prestalk cells.
Interaction partners:
- Oxidation resistance protein 1
Sequence:
MFSHCEGYRIEGGVTDGETNWNNNFNQNNNNNDNNKVMASIYKQQFYGKPHKTFMSLSSPNGPILVCIKKVGNSSDDFYLLVCTEKGFEEVRANKDSLQKSKTTRSFLKMRPTSLNVITSVRPELTKVPLCKVTDKSIQEELVKVCEPEFNKVIKSALLYCKESQRDDNDMLKNISSNVSQEYNDFLNFLGEKVELKDFSKFNGGLDIKNNSHGTHSIYSQINDVEVMYHVATMLPFFPSDPKQSERRKLISLDRVVIIFNDGSKPMSPNCIKSKSTQIIILIQPIKNFVGNSKTTIGISNDENRVVGEQPSPSLTTTTTTTTTTSPTINSNSPTPSNKIKYRVSISNRDEVPNYGPPLPDPPIFEKDDSFRNFLYQKMVGGAASLRNTPAFTSKNSEKASALINVISKYSTKGMEQI
Protein: Elongation factor 1-gamma, putative (Eurofung) (Q5AYR7)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Elongation factor 1-beta
- Elongation factor 1-alpha
- Elongation factor 3
- mRNA-nucleus export ATPase
- Elongation factor 2
- Small ribosomal subunit protein uS5
- 60S acidic ribosomal protein P0
- Small ribosomal subunit protein uS2
- 60S ribosomal protein L6
- 40S ribosomal protein S3
Sequence:
MAFGKLYGRPDNTRTIAVLVAAKHNDLELELVETQANPAADFNKSDAYTKIQPLGKIPAFEGANGFTLSEVIAIAVYVTSQNEKTTLLGKTKQDYASILRWLSFANSELLVSFGSWFRPLLGLDPYNKKNVEDASKAALKKLGVLNTHLTANTYLVGERITLADLFTASLLTRAFATVIDKKVRADYPAVTRWYQTIIDQSAFKAVVENPVLIDEAIKYTPPKKEEKPKKEAAPAAAAPAAEEDKPAPKPKHPLEALGKPTLILDDWKRTYSNEDTRSVAMPWFWQNYKPEEYSLWKVNYKYDNELKLTFMANNLIGGFHARLEASRKYLFGCQGVYGENYACVNRGVFLVRGQEALPAFDVAPDYESYEFIKLDHTNEADRKYVEDIWAWDTPVVVDGKELPNVDGHVFK
Protein: 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) (Q9U1K8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTMTASDKYTYQRTVLCLARVLAGIQPTPWDKVHVHLATHSTSHSASPPGNRLFALTLSGGHKTDMRGRSGGGGKAVQTLFRYCPQENAAGVFCLDTRAQDAVIALGIYFLEGGCQHEGQIVPYLLRLAKRSHSVGGKVQLLLEHPAVRHSGQVSGFARGDHPESGGNAERAGQHSQVEQGQQLRTAAHHPVQGHGAAALRLGAIDGSLCQQRSTAAVPHFSARAAAHPEGRRPRRHRLEQQCQRHCGGSFSSSERLAATHHFRPIIPRSMSGSLAQAQNASYDDGRQRCAGGKPSKPSLHSYFSVPYDPRTHFFTRYGSSFNQFPNMRVCESPTKGGPRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVTLLRELLQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNVMANAACVDLLVWAIRDETEADKLCGRLSQKLNLELSHKIVMDHMPLLMVCLEGLGKLAHKFPNIAGTSISYLRDFLVAPSPILGKLHDHAMQSLAQQKKEKELTPFKIAVQHSDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKVPSEQNALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQFHHVSDAVVNALGNIAANIQGDAEMLELLGKLLELFVQIGLDGERSYDNTPGAQKASSRAGNLGMLIPVIAVLVRRLPPIKNPRQRLHKLFKDFWAYCVVMGFTNARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRELNYTLAIKSDSVNELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENADEPSLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTPYTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQIPY
Protein: SnoRNA-binding rRNA-processing protein (A0A1D8PRE0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Ribosome biosynthesis protein
- Ribosomal RNA small subunit methyltransferase NEP1
- Rrp9p
- Ltv1p
- Pre-rRNA-processing protein PNO1
- rRNA adenine N
- RNA cytidine acetyltransferase
- rRNA-processing protein
- GTPase
- rRNA-processing protein
Sequence:
MGKITTSDTKTKQRHNPLLKDISSQGGNLRTVPRSSSSSSSQKKKSSKKQRHNDEDDEENGGGEGFLDASSSRKILQLAKEQQDELEQEDEIQNKPSFAQSFKNQQIDSEEEEEEDEYSDFEEEEEVEEIVYDEEDAEVDPKDAELFNKYFQSNGEANNNDDDNSFQPTINLADKILAKIQEKESQQQQQQQSSPDNSNEDAVLLPPKVILAYEKIGQILSTYTHGKLPKLFKILPSLKNWQDVLYVTNPNSWTPHATYEATKLFVSNLSSNEATVFIETILLPRFRDSIENSDDHSLNYHIYRALKKSLYKPGAFFKGFLLPLVDGYCSVREATIAASVLTKVSVPVLHSSVALTQLLTRDFNPATTVFIRVLIEKKYALPYQTLDELVFYFMRFRNATINQDENMENMDIDQEKTTKVNNGPQLPVVWHKAFLSFATRYKNDLTDDQKDFLLETVRQRFHPLIGPEIRRELLS
Protein: TEA domain family member 1 (Q3USK5)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR002603}.
Interaction partners:
Sequence:
MERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREIQAAIKVSSHIQVLARRKSRDFHSKLKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPTSAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
Protein: ATP synthase subunit alpha, mitochondrial (F4IMB5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}.
Interaction partners:
- ATP synthase subunit b, chloroplastic
- ATP synthase subunit d, mitochondrial
- ATP synthase subunit beta-3, mitochondrial
- ATP synthase subunit beta-2, mitochondrial
- ATP synthase subunit beta-1, mitochondrial
- ATP synthase subunit 9
- ATP synthase subunit a, chloroplastic
- ATP synthase subunit 9, mitochondrial
- ATP synthase gamma chain 1, chloroplastic
- ATP synthase subunit gamma, mitochondrial
Sequence:
MITRLFAQLVSLSIVTYWNDAIVATNFSWLFITFFVMTFTFRTFSRYFKKPIIWTFYFFLCLIAFLLLWAARIHINILFSFAFGDVYSFFMAGVFLFYGFGELLPIGSDSDVGEASWVVNPATGASGSGGNGWTESAANDPAREVSLAPFPLQLTHPVPFPAEPGSPDPVSPPPPIASFYSRIERAESLHAGNIELAEDLQRIQEMERNLENERSPYRGRELAARIDWEVRELEGKVARNRAWDMVRDAQLDIWRQGLDQELVRQQENESRLEERRAAELTNLFESRIRNFYANFQVDEIGRVVSVGDGIAQVYGLNEIQAGEMVLFANGVKGMALNLENENVGIVVFGGDTAIKEGDLVKRTGSIVDVPAGKAMLGRVVDAMGVPIDGKGALSDHEQRRVEVKAPGILERKSVHEPMQTGLKAVDSLVPIGRGQRELLIGDRQTGKTTIAIDTILNQKQINSRATSESETMYCVYVAIGQKRSTVGQLIQTLEEANALEYSILVAATASDPAPLQFLAPYSGCAMGEYFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKRSDQTGAGSLTALPVIETQAGDVSAYIPTNVISITDGQICLETELFYRGIRPAINVGLSVSRVGSAAQLKAMKQVCGSSKLELAQYREVAAFAQFGSDLDAATQALLNRGARLTEVPKQPQYAPLPIEKQILVIYAAVNGFCDRMPLDRISQYEKAIPNSVKPELLQALKGGLTNERKMEPDAFLKERALALI
Protein: Trans-3-hydroxy-L-proline dehydratase (T3LHyp dehydratase) (t3HypD) (EC 4.2.1.77) (Trans-L-3-hydroxyproline dehydratase) (Q92WR9)
Organism: Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Function: Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp), albeit with 150-fold lower efficiency. May be involved in the degradation pathway that converts t3LHyp to L-proline, which would allow R.meliloti to grow on t3LHyp as a sole carbon source. Displays no proline racemase activity.
Interaction partners:
Sequence:
MRSTKTIHVISAHAEGEVGDVIVGGVAPPPGDTIWEQSRWIAREQTLRNFVLNEPRGGVFRHVNLLVPPKHPDADAAFIIMEPEDTPPMSGSNSICVSTVLLDSGILPMKEPVTEITLEAPGGLVRVRAECRDGKAERIFVENLPSFAERLDAKLEVEGLGTLTVDTAYGGDSFVIVDAAAMGFALKPDEAHDIARLGVRITNAANAKLGFHHPENPDWRHFSFCLFAGPVERTAEGLRAGAAVAIQPGKVDRSPTGTALSARMAVLHARGQMGLSDRLTAVSLIGSTFSGRILGTTEVGGRPAVLPEISGRAWITGTHQHMLDPSDPWPEGYRLTDTWGAR
Protein: Beta-glucosidase 42 (AtBGLU42) (EC 3.2.1.21) (Q9FIW4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glucosidase that hydrolyzes scopolin and various beta-glucosides, cellooligosaccharides (mainly cellotriose) and laminarioligosaccharides. Can use p-nitrophenyl-beta-glucosides (pNP beta-Glc) and p-nitrophenyl-beta-D-fucosides (pNP beta-D-Fuc) as substrates, and, to a lower extent, beta-galactosides, beta-mannosides and beta-xylosides. Involved in the secretion of root-derived phenolics upon iron ions (Fe) depletion. Promotes disease resistance toward B.cinerea, H.arabidopsidis and P.syringae pv. tomato DC3000. Required during rhizobacteria-mediated (e.g. P.fluorescens WCS417r) broad-spectrum induced systemic resistance (ISR) against several pathogens.
Interaction partners:
- Transcription factor MYB72
- Feruloyl CoA ortho-hydroxylase 1
- ABC transporter G family member 37
- Ferric reduction oxidase 2
- Fe
- Scopoletin 8-hydroxylase
- Transcription factor MYB10
- Xanthotoxin 5-hydroxylase CYP82C4
- Transcription factor ORG3
- Oligopeptide transporter 3
Sequence:
MAQKLNLLNLAVPPVTHRSNFPSTFTFGVATSAYQIEGGWNEGKKGPSIWDKFTHIEGKILDGSNGDVAVDHYHRYKEDVDLIGQLGFGAYRFSISWSRIFPDGLGTEVNEEGIAFYNDLINTLLEKGIQPYVTLYHWDLPSHLQEAIGGWTNRKIVDYFGLYADACFANFGDRVKHWITLNEPLQTSVNGHCIGIFAPGRNEKPLIEPYLVSHHQVLAHATAVSIYRSKYKESQGGQIGLSVDCEWAEPNSEKPEDKVAADRRIDFQLGWFLDPLFFGDYPASMRQKLGDNLPRFTPEEKEFMLQNSWDFLGLNHYTSRLISHVSNKEAESNFYQAQELERIVELENGDLIGERAASDWLYAVPWGIRKTLNYMSKKYNHPPIFITENGMDDEDDGSASIHDMLDDKRRVDYFKSYLANVSQAIEDGVDIKGYFAWSLLDNFEWAQGYTKRFGLVYVDYKNGLTRHPKSSAYWFMKFLKGDEENKGKKE
Protein: Transcriptional activator protein DAL81 (Regulatory protein UGA35) (P21657)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2), urea (DUR1 and DUR2), arginine and allantoin.
Subcellular location: Nucleus.
Interaction partners:
- Protein DAL82
- Transcriptional activator protein UGA3
- Nitrogen regulatory protein DAL80
- Urea amidolyase
- Nitrogen regulatory protein GLN3
- 4-aminobutyrate aminotransferase
- Succinate-semialdehyde dehydrogenase [NADP
- Glutamyl-tRNA
- Ureidoglycolate lyase
- Allantoicase
Sequence:
MDPHQSPADNAASPTKSVKATTKNSSTNNNVNSNNSNNNSNHDILNFNDNYTTILQHLANDHPNILREKGGSQQQQHQQQQQQQQQQQQQQQQQSLDTLLHHYQSLLSKSDNAIAFDDNVSNSADHNGSNSNNNNNNNDISSPGNLMGSCNQCRLKKTKCNYFPDLGNCLECETSRTKCTFSIAPNYLKRTSSGANNNMPTSSNSKRMKNFEDYSNRLPSSMLYRHQQQQQQQQQQQRIQYPRSSFFVGPASVFDLNLTKHVRLDNVDQIQLSKTLSLRKVSPTAQFILQDDFDTTLHSKQEYEVDLVENLVHPHGHLLVEIFFKLIHPFLPILHERVFLEKYSRSYRELTAPLLASIYSLALQYWDFHPALLGFPKPDVTAQLNNIALETFYARVGRPKLSIIQTGLLILQCRSECHNNWVLCSSVVALAEELGLGVECNDWKLPKWEKDLRKRLAWAVWLMDKWCALNEGRQSHLILGRNWMIKLLNFDDFPLNSPTILNSLQNDQSGSSPSSSNDVKNHQIAFGNLPIFNINPTLEDFKNGTLMFQQMVSLSIILGEIMDTFYTQGSMTINKSIEQVLKLAKPLQLKLREWYHSLPKNLSMSYATPQKLNSNSTLTLAYFATEITLHRKIICALNPQTPKELVQVCRTAARTRLVAAIEFIRDLKNEHINAFWYNCSTGNLMLIGTFAALLYVTSATKEEAMIFRDYVRNYTWVLKIGSKYFDKLSNALNNMHLLFAQIPGLLTDEPVVVSPNSNINSVNPQRSGVQSQIPIQFNVGSPAMTEQGSPLNQWKNLPQEILQQLNSFPNGTTSTTTPVNPTSRQTQLESQGSPAINSANNNSNNTPLPFAPNKSSKKTSQSSPNVTPSHMSRHPPSNTSSPRVNSSTNVNSNTQMNASPLTSINETRQESGDAADEKTAGRERTANEESSTELKDDNPNSNQETSATGNQTIKMNDDKNVTINTRETPL
Protein: Ornithine decarboxylase antizyme 1 (ODC-Az) (P54370)
Organism: Rattus norvegicus (Rat)
Function: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination (By similarity). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).
Interaction partners:
- Ornithine decarboxylase
- Antizyme inhibitor 2
- Antizyme inhibitor 1
- Polyubiquitin-C
- Eukaryotic translation initiation factor 1
- Elongation factor 1-gamma
- Antizyme inhibitor 2
- Proteasome subunit beta type-6
- Proteasome subunit alpha type-7
- Large ribosomal subunit protein eL27
Sequence:
MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRVALHCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQCTLTEAKQVTWRAVWNGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLRADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED
Protein: Retrotransposon Gag-like protein 8B (Mammalian retrotransposon derived protein 8B) (Q17RB0)
Organism: Homo sapiens (Human)
Interaction partners:
- Retrotransposon-derived protein PEG10
Sequence:
MEGRVQLMKALLARPLRPAARRWRNPIPFPETFDGDTDRLPEFIVQTSSYMFVDENTFSNDALKVTFLITRLTGPALQWVIPYIKKESPLLSDYRGFLAEMKRVFGWEEDEDF
Protein: SVP1-like protein 2 (P50079)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in piecemeal microautophagy of the nucleus (micronucleophagy).
Subcellular location: Endosome membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Note=Recruitment to endosomes depends on binding to phosphatidylinositol 3-phosphate.
Interaction partners:
- Autophagy-related protein 2
- Autophagy-related protein 9
- Vacuolar protein sorting-associated protein 30
- Autophagy-related protein 18
- Autophagy-related protein 21
- Ubiquitin-like modifier-activating enzyme ATG7
Sequence:
MDVRRPIREAVNNRRKPKFLSVSFNQDDSCFSVALENGFRIFNTDPLTSKLSKTFKESATNQSRGTGIGYTRMLYRTNYIALVGGGKRPRHALNKLIIWDDLLQKETITLKFMSSIKDVFLSRIHIVVVLENTIEIFQFQTNPQRICPILDIPPNGSVDYVVCSSKHLQSQASQSQSKILEIIAFPSNKCVGQIQVADLSQIKYNSQNPKESALLPTSIIKAHKNPIKLVRLNRQGTMVATCSVQGTLIRIFSTHNGTLIKEFRRGVDKADIYEMSFSPNGSKLAVLSNKQTLHIFQIFETTNTETNTPDHSRANGSSHPLKNYIPKGLWRPKYLDSVWSICNAHLKNPIFDAHRNDNSGDVTHDNEFYKDRCRIGWCQDSNNREQDDSLVLVWQNSGIWEKFVILEKEQQDSSKTHYSLNESLRNEDTKSAGEPTRWELVRESWREL