wanglab/gogpt-training-data huggingface dataset:
Protein: Derlin-1 (AtDerlin1-1) (Q8VZU9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Protein OS-9 homolog
- Cell division control protein 48 homolog A
- ERAD-associated E3 ubiquitin-protein ligase component HRD3A
- NPL4-like protein 1
- AT2G21270 protein
- NPL4-like protein 2
- ERAD-associated E3 ubiquitin-protein ligase HRD1B
- ERAD-associated E3 ubiquitin-protein ligase HRD1A
- Derlin-2.2
- Heat shock 70 kDa protein BIP1
Sequence:
MSSPGEFYNSLPPITKAYGTLCFFTTVATQLGLVAPVHIALIPELVLKQFQIWRLITNLFFLGGFSINFGIRLLMIARYGVQLEKGPFERRTADFLWMMIFGSFTLLVLSVIPFFWTPFLGVSLVFMLLYLWSREFPNANISLYGLVTLKAFYLPWAMLALDVIFGSPIMPDLLGIIAGHLYYFLTVLHPLATGKNYLKTPKWVNKIVARWRIGAPVASVRQAGGVGAAGPGAGGGVGGGGAYSSARAPPESSNTAFRGRSYRLTD
Protein: Vitamin B12 transporter BtuB (Cobalamin receptor) (Outer membrane cobalamin translocator) (P06129)
Organism: Escherichia coli (strain K12)
Function: Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Is also a receptor for bacteriophages BF23 and C1, and for A and E colicins.
Subcellular location: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_01531, ECO:0000269|PubMed:12595710, ECO:0000269|PubMed:12652322, ECO:0000269|PubMed:2687240, ECO:0000269|PubMed:2982793}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01531, ECO:0000269|PubMed:12595710, ECO:0000269|PubMed:12652322, ECO:0000269|PubMed:2687240, ECO:0000269|PubMed:2982793}.
Interaction partners:
- Protein TonB
- Outer membrane porin F
- Biopolymer transport protein ExbD
- Biopolymer transport protein ExbB
- Tol-Pal system protein TolB
- Vitamin B12-binding protein
- Glutamate racemase
- Vitamin B12 import system permease protein BtuC
- Nucleoside-specific channel-forming protein Tsx
- Outer membrane protein A
Sequence:
MIKKASLLTACSVTAFSAWAQDTSPDTLVVTANRFEQPRSTVLAPTTVVTRQDIDRWQSTSVNDVLRRLPGVDITQNGGSGQLSSIFIRGTNASHVLVLIDGVRLNLAGVSGSADLSQFPIALVQRVEYIRGPRSAVYGSDAIGGVVNIITTRDEPGTEISAGWGSNSYQNYDVSTQQQLGDKTRVTLLGDYAHTHGYDVVAYGNTGTQAQTDNDGFLSKTLYGALEHNFTDAWSGFVRGYGYDNRTNYDAYYSPGSPLLDTRKLYSQSWDAGLRYNGELIKSQLITSYSHSKDYNYDPHYGRYDSSATLDEMKQYTVQWANNVIVGHGSIGAGVDWQKQTTTPGTGYVEDGYDQRNTGIYLTGLQQVGDFTFEGAARSDDNSQFGRHGTWQTSAGWEFIEGYRFIASYGTSYKAPNLGQLYGFYGNPNLDPEKSKQWEGAFEGLTAGVNWRISGYRNDVSDLIDYDDHTLKYYNEGKARIKGVEATANFDTGPLTHTVSYDYVDARNAITDTPLLRRAKQQVKYQLDWQLYDFDWGITYQYLGTRYDKDYSSYPYQTVKMGGVSLWDLAVAYPVTSHLTVRGKIANLFDKDYETVYGYQTAGREYTLSGSYTF
Protein: DNA polymerase delta subunit 2 (Pol31 polymerase delta subunit) (Q9W088)
Organism: Drosophila melanogaster (Fruit fly)
Function: Accessory component of both the DNA polymerase delta complex and possibly the DNA polymerase zeta complex (By similarity). As a component of the delta complex, participates in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair (By similarity). Appears to promote the function of the DNA pol-delta complex accessory subunit PolD3 in both embryonic and postembryonic somatic cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:31100062}. Nucleus, nucleoplasm {ECO:0000269|PubMed:31100062}. Note=In embryos, accumulates in the nucleus during interphase but disperses into the nucleoplasm at the onset of mitosis. {ECO:0000269|PubMed:31100062}.
Interaction partners:
- DNA polymerase delta subunit 3
- DNA polymerase delta catalytic subunit
- DNA polymerase zeta catalytic subunit
- DNA polymerase zeta subunit 2
- DNA polymerase alpha catalytic subunit
- DNA polymerase epsilon catalytic subunit 1
- DNA primase large subunit
- DNA polymerase alpha subunit B
- DNA primase small subunit
- Proliferating cell nuclear antigen
Sequence:
MTNRLETKYENLSSIFRLKGHDYQKQFFHLYAHRLAEMTRLLTPLAQKKWGNKEPIKKLCELRGEQDVHCILIGTIFKHQAHKPSILRDISEENQLAPQPPRQNYSDPEDKIVLEDELQRVRLQGKLNGQLLATGVVCAALGGTDSDGFFNVEDILFYESGPQKPLAPIKRSRLLVLASGLDQLQAHKFVEALNLFQYWLAGSLGNNKEAGSMVRLIVAGNSVRASAMAHVPTLQVARTQANANDTVQAVSQLDQWFASWARSLPVDIMPGPYDPANFMLPQQPFHKCMFPQAAQLATFQAVTNPYSCRLDEALVVGTSGQNVSDLLRSTSLDSALEALRCTLTWGHVAPTAPDTLACYPYIESDPFILRECPHVYYAGNCESFATELHEGSEGKRTRLVCVPSFSKTQSVAVVDLDTLDCRMVNFSVDAE
Protein: Major facilitator superfamily protein (F4IMD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEEYRLGELRHLLTTVFLSGFSEFLVKPVMTDVTVAAVCSGLNETCSLAVYLTGVEQVTVGLGTMVMMPVIGNLSDRYGIKTLLTLPMCLSILPPAILAYRRDTNFFYAFYITKILFDMVCQGTVDCLAHAYVAKNVCGRKRISMFGVLAGVRSISGVCATFSARLLPIASIFQVAAISFFFGLVYMRVFLKERLHDDDEDDCDEDDNTSGRNHHDGGDLTMLAEPILRDAPTKIHIVLNTKYSSLKDMVSLIKNSTILVQTLVVTFFATFAQSGMQSAFLYFLKARFGFNKNDFAELILLVTIIGSISQLFILPKLVSAIGERRVLSTGLLMDSVNAACLSVSWSAWVPYATTVLVPVTMFVVLLQDKWDPVNRGRSKDAYPG
Protein: GTP-binding protein 10 (Protein obg homolog 2) (ObgH2) (A4D1E9)
Organism: Homo sapiens (Human)
Function: May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:17054726}. Chromosome {ECO:0000269|PubMed:17054726}. Note=Found in the dense fibrillar compartment region of the nucleolus. At the onset of mitosis moves to the chromosome surface and remains there until anaphase. Gradually re-assembles into the nucleolus at late anaphase to telophase.
Interaction partners:
- Mitochondrial assembly of ribosomal large subunit protein 1
- Probable ATP-dependent RNA helicase DDX28
- Large ribosomal subunit protein uL11m
- rRNA methyltransferase 3, mitochondrial
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein mL62
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL32m
Sequence:
MVHCSCVLFRKYGNFIDKLRLFTRGGSGGMGYPRLGGEGGKGGDVWVVAQNRMTLKQLKDRYPRKRFVAGVGANSKISALKGSKGKDCEIPVPVGISVTDENGKIIGELNKENDRILVAQGGLGGKLLTNFLPLKGQKRIIHLDLKLIADVGLVGFPNAGKSSLLSCVSHAKPAIADYAFTTLKPELGKIMYSDFKQISVADLPGLIEGAHMNKGMGHKFLKHIERTRQLLFVVDISGFQLSSHTQYRTAFETIILLTKELELYKEELQTKPALLAVNKMDLPDAQDKFHELMSQLQNPKDFLHLFEKNMIPERTVEFQHIIPISAVTGEGIEELKNCIRKSLDEQANQENDALHKKQLLNLWISDTMSSTEPPSKHAVTTSKMDII
Protein: PID domain-containing protein (A5JYR4)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAQKSDISVETANATSGKPNPPSPKSRLAMLKRTKKASNASSDPFRFQNNGISYKGKLIGEQDVDKARGDAMCAEAMRTAKSIIKAAGAHKTRITLQINIDGIKVLDEKSGAVLHNFPVSRISFIARDSSDARAFGLVYGEPGGKYKFYGIKTAQAADQAVLAIRDMFQVVFEMKKKQIEQVKQQQIQDGGAEISFQSKKEGGVAVADLLDLESELQQIERGVQQLSTVPTNCDAFGASPFGDPFVDSFNSTATSNGTANMSGTQVPFGGLQLPQVQQMQMPMVQIPQQSHQNWPTSGAGSFDAWGQQQQQQQMHHAHSTPAFGTNGFSDTNPFASAFNTQAPPPPLPTVAPTQYRDPFSVHSSAIPNSNIDWTGTGTTKENMAPSTNIQQQQSSLHHASTFANFGDNKAETWSEKKVTSLEEAFTKLVDMDALVGGQGIKETKKNPFEHILNPPKASLNSMSTTCSAAQMAATQQHTTSSHADPFGDDFFR
Protein: Adenylyl cyclase-associated protein (CAP) (P36621)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.
Interaction partners:
- Adenylate cyclase
- Protein app1
- Cofilin
- Actin
- Twinfilin
- Profilin
- Centractin
- Actin-like protein arp10
- Uncharacterized WD repeat-containing protein C9G1.05
- Actin-related protein 2
Sequence:
MSDMINIRETGYNFTTILKRLEAATSRLEDLVESGHKPLPNMHRPSRDSNSQTHNISFNIGTPTAPTVSTGSPAVASLHDQVAAAISPRNRSLTSTSAVEAVPASISAYDEFCSKYLSKYMELSKKIGGLIAEQSEHVEKAFNLLRQVLSVALKAQKPDMDSPELLEFLKPIQSELLTITNIRDEHRTAPEFNQLSTVMSGISILGWVTVEPTPLSFMSEMKDSSQFYANRVMKEFKGKDDLQIEWVRSYLTLLTELITYVKTHFKTGLTWSTKQDAVPLKTALANLSASKTQAPSSGDSANGGLPPPPPPPPPSNDFWKDSNEPAPADNKGDMGAVFAEINKGEGITSGLRKVDKSEMTHKNPNLRKTGPTPGPKPKIKSSAPSKPAETAPVKPPRIELENTKWFVENQVDNHSIVLDSVELNHSVQIFGCSNCTIIIKGKLNTVSMSNCKRTSVVVDTLVAAFDIAKCSNFGCQVMNHVPMIVIDQCDGGSIYLSKSSLSSEVVTSKSTSLNINVPNEEGDYAERAVPEQIKHKVNEKGELVSEIVRHE
Protein: C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)] (P19876)
Organism: Homo sapiens (Human)
Function: Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
Subcellular location: Secreted.
Interaction partners:
- C-X-C motif chemokine 5
- C-X-C chemokine receptor type 2
- C-X-C motif chemokine 6
- Growth-regulated alpha protein
- C-X-C chemokine receptor type 1
- Eotaxin
- C-X-C motif chemokine 2
- Cytokine SCM-1 beta
- C-X-C motif chemokine 10
- C-X-C motif chemokine 11
Sequence:
MAHATLSAAPSNPRLLRVALLLLLLVAASRRAAGASVVTELRCQCLQTLQGIHLKNIQSVNVRSPGPHCAQTEVIATLKNGKKACLNPASPMVQKIIEKILNKGSTN
Protein: T. brucei spp.-specific protein (Q383Q7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPRGGTDYLEALSVPKHDVTGVKGEGVPLRKRLQPVQVTGYDSTAKIGRSTRRQELRAALLEEELRGGGLCGGCRRVALCVSVFALLAVLAVAAMMYFPQGREILLPLLSQLRGYLGV
Protein: 2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase) (P9WQB3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (alpha-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Active on small alpha-keto acids such as 3-methyl-2-oxobutanoate, pyruvate, alpha-ketovalerate, and alpha-ketobutyrate; only uses acetyl-CoA. Complements an E.coli deletion.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00572}.
Interaction partners:
- 3-isopropylmalate dehydratase large subunit
- 3-isopropylmalate dehydratase small subunit
- Dihydroxy-acid dehydratase
- Branched-chain-amino-acid aminotransferase
- Propanal dehydrogenase
- Putative acetolactate synthase small subunit
- Acetolactate synthase large subunit IlvB1
- Acetolactate synthase large subunit IlvG
- Putative acetolactate synthase large subunit IlvX
- Biotin-dependent acyl-coenzyme A carboxylase alpha3 subunit
Sequence:
MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR
Protein: AT29177p (Q8MSL0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDEEGHDLLGKRTMDFKVSYLDTGLASTYFSEADQLVVPPSTSPTAHALPPPVTPTRPNRRYKTQLRDFLSTCRSKRKLQQQNQPQTQQTSPLGGQVGSPAPAVAVEYLPDPAAAVAAAYSNLNPMYTTSPYASAADNLYMGSSMPANAFYPVSENLFHQYRLQGAVGGYYTDYPHSGAPASAYVANGFLSYDGYAIASKADEKWQETGKYYSGYSSGYGSPTSTPQQIPLKTPKSSPQVMEVISCSSDGPSPVGGATPNGVGSVTPKVELAGTTAAAAAGQDPYERQTVLMWGTTHSSGVPLNSHGGRTGAGNPASPQRSTPLGNGLGYASANNNNNDLEPATAAKWNGTKELPGKSGSASTPESYQMQHDDSGLYSASSHTTSPQQQQQQQLQQSQRGVGSNVSAPSSSLTSTGTDQQAVHPSSCHQQQQQQQQQHHHAHPHPHSHHHHHHHHHHETAHQHSSEVWTPASYTQYSQYFTYHHPHPHPHHPSAGGGGHVPAQSHHLHHGHR
Protein: Small ribosomal subunit protein mS23 (28S ribosomal protein S23, mitochondrial) (MRP-S23) (S23mt) (Q2NL27)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10938081, ECO:0000269|PubMed:24799711}.
Interaction partners:
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein bS1m
- Small ribosomal subunit protein mS34
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein mS29
Sequence:
MAGSRLETVGSIFTRTRDLIRAGVLKEKPLWFDVYNAFPPLREPVFRRPRLRYGKAKSPTQDIYYHEDQIRAKFYAAYGSGPKAFDLFNPNFKSTCQRFVEKYIELQKLGETDEEKLFVEAGKALLAEGVILRRVEKARTQQEGSQVSRKSESMGVESQTALEENPPLKEVPQAQHLESPGEESKGLSPP
Protein: RNA helicase (EC 3.6.4.13) (A6M930)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI
Protein: Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1) (P05121)
Organism: Homo sapiens (Human)
Function: Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis.
Subcellular location: Secreted {ECO:0000269|PubMed:2430793}.
Interaction partners:
- Urokinase-type plasminogen activator
- Vitronectin
- Tissue-type plasminogen activator
- Urokinase plasminogen activator surface receptor
- Plasminogen
- Prolow-density lipoprotein receptor-related protein 1
- Plasminogen activator inhibitor 2
- Type-1 angiotensin II receptor
- Vitamin K-dependent protein C
- C-C motif chemokine 2
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Protein: DNA-binding response regulator PhoP2 (Q1D8M8)
Organism: Myxococcus xanthus (strain DK1622)
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
Sequence:
MNTATSTPPLRPAILIVEDDAHLRVGLRDNLLDEGYLVAEAPSTRDAERLLQERAFDLLILDVMLPGEDGYSFCRRLRTQGNKSMVLMLTARSLEDDILRGFEVGAQDYLTKPYRLRELLARVRALVRRSGTAPPEQMGFSSFTLDLGRRQVSRADGSVVELTRTEFDLLAFLLRHQDRALPRGEILDAVWGRDVVVDPRTVDNFVSSLKKKLGWTSTSGFSIHTIRGVGYRMEVASS
Protein: Cytochrome bo(3) ubiquinol oxidase subunit 2 (Cytochrome b562-o complex subunit II) (Cytochrome o ubiquinol oxidase subunit 2) (Cytochrome o subunit 2) (Oxidase bo(3) subunit 2) (Ubiquinol oxidase chain B) (Ubiquinol oxidase polypeptide II) (Ubiquinol oxidase subunit 2) (P0ABJ1)
Organism: Escherichia coli (strain K12)
Function: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:6365921}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:6365921}.
Interaction partners:
- Cytochrome bo
- Protoheme IX farnesyltransferase
- Cytochrome bo
- Cytochrome bo
- NADH-quinone oxidoreductase subunit H
- NADH-quinone oxidoreductase subunit C/D
- NADH-quinone oxidoreductase subunit M
- Succinate dehydrogenase cytochrome b556 subunit
- NADH-quinone oxidoreductase subunit N
- Cytochrome bd-I ubiquinol oxidase subunit 1
Sequence:
MRLRKYNKSLGWLSLFAGTVLLSGCNSALLDPKGQIGLEQRSLILTAFGLMLIVVIPAILMAVGFAWKYRASNKDAKYSPNWSHSNKVEAVVWTVPILIIIFLAVLTWKTTHALEPSKPLAHDEKPITIEVVSMDWKWFFIYPEQGIATVNEIAFPANTPVYFKVTSNSVMNSFFIPRLGSQIYAMAGMQTRLHLIANEPGTYDGISASYSGPGFSGMKFKAIATPDRAAFDQWVAKAKQSPNTMSDMAAFEKLAAPSEYNQVEYFSNVKPDLFADVINKFMAHGKSMDMTQPEGEHSAHEGMEGMDMSHAESAH
Protein: SRGAP3 protein (Q8IXS7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASEAYMSKINIAKRRANQQETEMFYFTNGPDDVFPICHPRL
Protein: Synaptotagmin-5 (Synaptotagmin IX) (Synaptotagmin V) (SytV) (P47861)
Organism: Rattus norvegicus (Rat)
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:12966166}; Single-pass membrane protein {ECO:0000269|PubMed:12966166}. Recycling endosome membrane {ECO:0000269|PubMed:12966166}; Single-pass membrane protein {ECO:0000269|PubMed:12966166}. Note=In mast cells, localizes to the endocytic recycling compartment.
Interaction partners:
Sequence:
MFPEPPTPGSPAPETPPDSSRIRQGAVPAWVLATILLGSGLLVFSSCFCLYRKRCRRRMGKKSQAQAQVHLQEVKELGRSYIDKVQPEIEELDPSPSMPGQQVLDKHQLGRLQYSLDYDFQTGQLLVGILQAEGLAALDLGGSSDPYVSVYLLPDKRRRHETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVNLGRPVQAWRELQVAPKEEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGTAVGGAGLRHWADMLANPRRPIAQWHSLRPPDRARPIPAP
Protein: Muscarinic acetylcholine receptor M4 (P08173)
Organism: Homo sapiens (Human)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Kininogen-1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
Protein: Uncharacterized protein (Q57U79)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Peptidyl-prolyl cis-trans isomerase
- Uncharacterized protein
- 50S ribosomal protein L13, putative
- Uncharacterized protein
- Uncharacterized protein
- Large ribosomal subunit protein uL4m
- Uncharacterized protein
- Uncharacterized protein
- Tetratricopeptide repeat
Sequence:
MRRCGNDRAVALLRATTEAMRLVRLKLSPDRTRNEEIQDRQNAFVWSDEHIFRPHQHFTHDPCSWSRSLEQSMKKQRKLSMVERLRSLEQRQLEEKQSASATAGGSSKCANHMDGEKAEGPRFYGAVGDSEDLKEYVANEDYFYTMQQEEKPNDPPLQELVDEVQSLHVLLSSPRYEDTPLATVERLQCAYSEALRCVFDRVRNASVGKTMSCNALLFSWSLLLQGLPALLESLAEKRTEECLVRALSTVHEALNIVLQEFNRITHSKERVELLPLEGWIESLDVVTHPLTNKDYTSLKGNIRLPESSFKPQCKLDSATVEFVHSRAIQAAAIRMIENDQSDVETEPLDPYHLYILLRCMVRLAEKGVNDSHIHRAALLTGMVGERIFSSLERTVAPPRRYSLRHALLGKQLRDASKPHAIPLDVCAPPGGVKKPPTAADDVLLLTRACTLLMNVATNVLPQTKFKVLETVDTVLKTLSYAPNYDLSTADTVIFSNMVLEELHHVDEASATDRHLRVLLLLSRLRLSMCADRSALSHLLSCLCNLLPPHSIQQDKLREWKRLRGLVMRHLLYSVRGEEVEQHYTRVLKSSETWVEHLAFGQYSGGLPLSLWLEACHIYLTAGRKLTVSCAEALITLRGRCKDGGVLRSSNSAGVCPLDFVSVTLLAQLLEVVSHGCCSADDLVASPVAWDKVRQTIQGAIGEDENTIQLLRAGRLCVADRQATGSLVTTYP
Protein: Microphthalmia-associated transcription factor (Q08874)
Organism: Mus musculus (Mouse)
Function: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Subcellular location: Nucleus {ECO:0000269|PubMed:8622664}. Cytoplasm {ECO:0000250|UniProtKB:O75030}. Lysosome membrane {ECO:0000250|UniProtKB:O75030}. Note=When nutrients are present, recruited to the lysosomal membrane via association with GDP-bound RagC/RRAGC (or RagD/RRAGD): it is then phosphorylated by MTOR. Phosphorylation by MTOR promotes ubiquitination and degradation. Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus. Phosphorylation by MARK3/cTAK1 promotes association with 14-3-3/YWHA adapters and retention in the cytosol. {ECO:0000250|UniProtKB:O75030}.
Interaction partners:
- Transcription factor E3
- Transcription factor EB
- Mitogen-activated protein kinase 3
- Tyrosinase
- Mitogen-activated protein kinase 1
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
- Transcription factor PU.1
- L-dopachrome tautomerase
- Melanocyte-stimulating hormone receptor
- Transcription factor Jun
Sequence:
MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSSSSAEHSGASKPPLSSSTMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVAVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRHQVKQYLSTTLANKHASQVLSSPCPNQPGDHAMPPVPGSSAPNSPMAMLTLNSNCEKEAFYKFEEQSRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHANRHLLLRVQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQELVQHQADLTCTTTLDLTDGTITFTNNLGTMPESSPAYSIPRKMGSNLEDILMDDALSPVGVTDPLLSSVSPGASKTSSRRSSMSAEETEHAC