wanglab/gogpt-training-data huggingface dataset:
Protein: NXF2 (Q99NI0)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MFVQKNINSETYKQRYGLPYKRSERFYHSEYKMNYNHGFQGRKRGVNYIWSQFDRKNNHFDHYGAPYAMGMKRRRERCSYDDQYFLNVWDDSKTEEGETDLDAENETEEKWYKVTIPSGRKYEKTWLMRSIQNFCSEPFIPVDFHYDKTQARFFVQNAKTASALKDVSYRICDETSRKIAIFVSPSVVPYSVQNKFTSEQMEYIRESMMNRYDASQKALDLEKFRFDQDLMDKDIDMMLNRRSCMVATLQIIQSDIPELLSLNLTNNKLYQLDGLSDMTEKAPHVKILNLSRNKLKSFTELEKVKELKLEELWLEGNPFCNCFLDHFEYISTIHDLFPKLLRLDGEEIIVPKRNLQNGKGLIVPTRNLQNGKDLIVPTGNPQDGKDLIVPTGNPQDGKDLIVPTGNPQDGKDLIVPTKMDIEVPQPCKESCNTSEVIKNLVLQFLKEYYLFYDNGDRLRLLDAYHDQACFSLSVPFDVSDPNLNNLEEYFKYSRDLKRQQDSSMRMQLLKHTKHDIVNSLSLLPKTQHDLCSFLVDLFLHTEMMLCFSVNGLFMEVEGKCRGCIRAFTRIFIAIPCSDSRICIMNDELIVRNASPKEIQKAFTSLPAPDTSFKPLLSEEQQEMVKSFSVQSGMKLDWSQKCLQDNEWDYTKAGEAFTALQNEGKIPKEFFK
Protein: Non-structural protein V (P0C774)
Organism: Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus)
Function: Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Moderately affects the type II interferon signaling.
Subcellular location: Host cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MAEEQARHVKNGLECIRALKAEPIGSLAVEEAMAAWSEISDNPGQDRATCKEEEAGSSGLSKPCLSAIGSTEGGAPRIRGQGSGESDDDAETLGIPSRNLQASSTGLQCYHVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDDESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGGEIHELLKLQSRGNNFPKLGKTLNVPPPPNPSRASTSETPIKKGHRREIGLIWNGDRVFIDRWCNPMCSKVTLGTIRARCTCGECPRVCEQCRTDTGVDTRIWYHNLPEIPE
Protein: HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) (Q8R316)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:15235594}.
Interaction partners:
- Paired amphipathic helix protein Sin3a
Sequence:
MVWEVKTNQMPNAVQKLLLVMDKRAPGMSDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSAIYQLSSDVSHQEYPRSSWSQNTSDIPENTHREDEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSGPAFPHDHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTIWHCFLKGTRLCFHKESNKEWQDVEDFARAASCDNEEEIQMGTHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEIHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGGPGTGQEFSGSEFSKSCGSPGSSQLSSSSLYAKAVKSHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
Protein: Fanconi anemia group G protein (Q7SZH6)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MKRLRCGTAPEPGCLQAWAAECEALAGRWRAARGSAYGGAAAAARQLRGAFGELLLQMRGLPPALPMMPLELTVLYNSLLFVMGTSDCAIKGEAEGIRQGLLRVLEACGTSGQDPSTQKLWQKVLQEVTVEELQAPLHRLGALQAAWWLATSCLQNIIDLFRLLSSAEDPERAPCRAEKNELLTLLKAWRTPAEEASVSLVQSTEDLKETLCTAAAFLQGLQELEAGNLSTTLCLLQEAAGGFCSKRVLAQIYVCLGCCAQRMGKPQTALQHLKQALQVDFQCHPALSHTAAVYHELGETDAELQALYLLYEAVEKNPPSATSSSTYFLIRAELLVNTPILASLLRHHHPSEVKYLLAQRCLRDGRVADAVEHYLDFLSLLQEGLQQQVPLDGGSPLPRIPEVSLEAASALEQDGRHQDSLTVCDEVISRTTNLIPKIIQVEEKLEQPECASLETGLAGGLLSQKRESLCCLTWRAAAYLHQGWVWSKLGKGKEAIMQFSRCLNDLLRFQPRGCGVEPAESLLPEVKVLQKIRLLSLIGRGMQFLEQEKHKEALLDFQHGLQISPDDPAAASYLVQVLWKLNRKEEAADYWQKYLESPAGEDGQQERQGRHFPLYLDSCLKQATFPQNESLARCIQDYLRTTRQDSSR
Protein: E3 ubiquitin-protein transferase MAEA (Macrophage erythroblast attacher) (D6REW7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
Interaction partners:
Sequence:
MAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSGCPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKTCKKALQPSRREPAGRGAPGHGHAGLPARHAHLPVQGPSGPCTVADADPAVPVRQLPTTPAGKQFCVHPHPAGWPLSHQDT
Protein: Ddx60 protein (Q811K8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MEKEYTGFLEIMSHLILETMSKADYSSLFNDFVESEFFLIDGDSLLITCVCERSLKPGQSLHFFYLVERYLLDVISKGGQFAIVFFKDAEYAYFNVPELLTLRTALILHLQKNTTIEVWTKFSNCLSEEWNICLGQSCPYFLILADEGLNDLQTHLFNFVVIQAWAAKVNIVLFSGQTSDILRLYAYFMQSSHVMQMFFKEEKRRIMIVYKSLIQQLEKYRDMALAHLFGDLKFNDMEEKVCETVSLLKQLWPEGSDIRRVFCVTSCSLFLEMYHCYLESREKGASEEMSKVKQKTDNCLTLKDMEDFCKLHCLSVALLLHVPLSQRARSRFITANWIQDLKTVLKMKKWCEYFILSNLDMFESWSLNLLHLSGLSDEPLLRNIAFYYENENKEGLDLNVGDAIMNEYVHLWDTVSKLVRKFDVGKPIPLRTTKVHFLEKTPSPIKESSQEMMPNLGFIPMSCNLVDEFTGDILKDLPFLTSDDPIVTSLVKHKEFDELVHWHSHRPLSDDYDRTKVNSGDRRDPNHLKSLQKYHSFQRFYGESLESVTSKTITTQGPKPKKDCIKSKSTKAHETKAEIIKKKKKK
Protein: Eyes absent homolog (EC 3.1.3.48) (F1LX86)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- SIX homeobox 1
Sequence:
MEDTQDLNEQSVKKTCPESDVSEPQNSRSMEMQDLASPHALVGGSDTPGSSKLDKSGLSSTSVTTNGTGGDNMTVLNTADWLLSCNTPSSATMSLLAVKTEPLHSSETTTTTGDGALDTFTGSVITSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTAYSQTGQPYSLPAYDLGVMLPAIKTESGLPQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTADGTSSSTSTYQLQESLQGLTSQPGEFDTVQSPSTPIKDLDDRTCRSSGSKSRGRGRKNNPSPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHATASSANLCLPTGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCVNVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIMQRFGRKVVYVVIGDGVEEEQAAKKHNMPFWRISSHSDLLALHQALELEYL
Protein: Killer cell immunoglobulin-like receptor 3DL3 (CD158 antigen-like family member Z) (Killer cell inhibitory receptor 1) (CD antigen CD158z) (Q8N743)
Organism: Homo sapiens (Human)
Function: Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Killer cell immunoglobulin-like receptor 2DL3
- Killer cell immunoglobulin-like receptor 3DL1
- Killer cell immunoglobulin-like receptor 2DL1
- Killer cell immunoglobulin-like receptor 3DL2
- HLA class I histocompatibility antigen, B alpha chain
- HLA class I histocompatibility antigen, A alpha chain
- Natural killer cells antigen CD94
- HLA class I histocompatibility antigen, alpha chain G
- NKG2-A/NKG2-B type II integral membrane protein
- NKG2-C type II integral membrane protein
Sequence:
MSLMVVSMACVGFFLLEGPWPHVGGQDKPFLSAWPGTVVSEGQHVTLQCRSRLGFNEFSLSKEDGMPVPELYNRIFRNSFLMGPVTPAHAGTYRCCSSHPHSPTGWSAPSNPVVIMVTGVHRKPSLLAHPGPLVKSGETVILQCWSDVRFERFLLHREGITEDPLRLVGQLHDAGSQVNYSMGPMTPALAGTYRCFGSVTHLPYELSAPSDPLDIVVVGLYGKPSLSAQPGPTVQAGENVTLSCSSRSLFDIYHLSREAEAGELRLTAVLRVNGTFQANFPLGPVTHGGNYRCFGSFRALPHAWSDPSDPLPVSVTGNSRHLHVLIGTSVVIIPFAILLFFLLHRWCANKKNAVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQRPKTPPTDTSV
Protein: Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) (Q13164)
Organism: Homo sapiens (Human)
Function: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
Subcellular location: Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase 5
- Rap guanine nucleotide exchange factor 3
- Myocyte-specific enhancer factor 2A
- A-kinase anchor protein 6
- Myocyte-specific enhancer factor 2C
- Ribosomal protein S6 kinase alpha-3
- Nuclear factor erythroid 2-related factor 2
- Protein kinase C zeta type
- Gap junction alpha-1 protein
- Nuclear receptor subfamily 4immunitygroup A member 1
Sequence:
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
Protein: Inka box actin regulator 2 (E9PR53)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTMESREMDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGGPVPGSPEGPRTQCEHPCWEGGRGPARPTVCSPSSQPSLEQPEPTSGAFPIRCS
Protein: Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (P20004)
Organism: Bos taurus (Bovine)
Function: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Subcellular location: Mitochondrion {ECO:0000255}.
Interaction partners:
- Citrate synthase, mitochondrial
- Isocitrate dehydrogenase subunit alpha, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- Isocitrate dehydrogenase subunit beta, mitochondrial
- ATP-citrate synthase
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Citrate synthase
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
Sequence:
MAPYSLLVSRLQKALGARQYHVASVLCQRAKVAMSHFEPNEYIRYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDHLIEAQLGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRADIANLADEFKDHLVPDSGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGSVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLQCKSQFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPDADELPRAEFDPGQDTYQHPPKDSSGQQVDVSPTSQRLQLLEPFDKWDGRDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINVENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIKGLKDFAPGKPLTCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQK
Protein: ESRRA protein (Estrogen-related nuclear receptor alpha) (Estrogen-related receptor alpha) (HCG2016877, isoform CRA_b) (Q569H8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR002527}.
Interaction partners:
Sequence:
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
Protein: Ribulose bisphosphate carboxylase large chain (RuBisCO large subunit) (EC 4.1.1.39) (Q32753)
Organism: Oryza sativa (Rice)
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229, ECO:0000256|HAMAP-Rule:MF_01338, ECO:0000256|RuleBase:RU000302}.
Interaction partners:
Sequence:
MSPQTETKASVGFKAGVKDYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVVGEDNQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPTYSKTFQGPPHGMEVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTTLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGAVVGKLEGEREMTLGFVDLLRDDFIEKDRARGIFFTQDWVSMPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAAANRVALEACVQARNEGRDLAREGNEIIRSACKWSPELAAACEIWKAIKFEFEPVDKLDS
Protein: UPF0415 protein C7orf25 (Q9BPX7)
Organism: Homo sapiens (Human)
Interaction partners:
- Proteasome subunit alpha type-2
Sequence:
MSAHSMLCERIAIAKELIKRAESLSRSRKGGIEGGAKLCSKLKAELKFLQKVEAGKVAIKESHLQSTNLTHLRAIVESAENLEEVVSVLHVFGYTDTLGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWLGRGQYGDKSIIEQAEDFLQASHQQPVQYSNPHIIFAFYNSVSSPMAEKLKEMGISVRGDIVAVNALLDHPEELQPSESESDDEGPELLQVTRVDRENILASVAFPTEIKVDVCKRVNLDITTLITYVSALSYGGCHFIFKEKVLTEQAEQERKEQVLPQLEAFMKDKELFACESAVKDFQSILDTLGGPGERERATVLIKRINVVPDQPSERALRLVASSKINSRSLTIFGTGDTLKAITMTANSGFVRAANNQGVKFSVFIHQPRALTESKEALATPLPKDYTTDSEH
Protein: Alpha-(1,4)-fucosyltransferase (EC 2.4.1.-) (FT4-M) (FucTC) (Fucosyltransferase 13) (AtFUT13) (Galactoside 3(4)-L-fucosyltransferase) (Q9C8W3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in cell wall synthesis. Catalyzes alpha-1,4 glycosidic linkages and generates Lewis-a epitopes.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.
Interaction partners:
- Beta-1,3-galactosyltransferase GALT1
- Beta-hexosaminidase 1
- Alpha-mannosidase 2
- Beta-hexosaminidase 3
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Beta-1,2-xylosyltransferase
- Beta-hexosaminidase 2
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Probable alpha-mannosidase At5g66150
- Probable alpha-mannosidase At5g13980
Sequence:
MPMRYLNAMAALLMMFFTLLILSFTGILEFPSASTSMEHSIDPEPKLSDSTSDPFSDVLVAYKKWDFEVGCARFRENHKDAILGNVSSGSLQEFGCGKLKMKHVKVLVKGWTWIPDNLENLYSCRCGMTCLWTKSSVLADSPDALLFETTTPPLQRRVGDPLRVYMELEAGRKRSGREDIFISYHAKDDVQTTYAGSLFHNNRNYHISPHKNNDVLVYWSSSRCLPHRDRLAKSLLDLIPHHSFGKCLNNVGGLDSALSMYPECVAEHNAEAKWYDHLHCAMSHYKFVLAIENTAVESYVTEKLFYALDSGSVPIYFGASNVQDFVPPHSVIDGSKFGSMQELAAYVKRLGDDPVAYSEYHAWRRCGLMGNYGKTRAVSLDTLPCRLCEEISRRGGKNAGV
Protein: Acetyl-CoA carboxylase 1 (G3H9D1)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
- Acetyl-CoA carboxylase 1
- Breast cancer type 1 susceptibility protein homolog
- Fatty acid synthase
- Delta-1-pyrroline-5-carboxylate synthase
- Glutamyl-tRNA
- Biotin--protein ligase
- Sterol regulatory element-binding protein 1
- Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Sequence:
MGVQVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVIAKMQLDNPSKVQQAELHTGILPKIQSTALRGEKLHRVFHYVLDNLVNVMSGYCLPDPFFSSRVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPLNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRMSFASNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEIMGCFCDSPPQSPTFPESGHTSLYDEDKAPRDEPIHILNVAIKTDGDIEDDRLAAMFREFTQQNKATLVEHGIRRLTFLVAQKDFRKQVNCEVDQRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTTTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQIGMVAWKMSLKSPEYPDGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVAANSGARIGLAEEIRHMFHVAWVDPEDPYKGYKYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGLGAENLRGSGMIAGESSLAYDEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPIDRIIEFVPTKAPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECSQPVMVYIPPQAELRGGSWVVIDPTINPRHMEMYADRESRGSVLEPEGTVEIKFRKKDLVKTMRRVDPVYIHLAERLGTPELSPIERKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVINDILDWKTSRSFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLVEWLEKQLTEEDGVRSVIEENIKYISRDYVLKQIRSLVQANPEVAMDSIVHMTQHISPTQRAEVVRILSTMDSPST
Protein: Eva-1 homolog A, regulator of programmed cell death (C9J5M4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEV
Protein: Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein) (Q12857)
Organism: Homo sapiens (Human)
Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor SOX-9
- Nuclear factor 1 B-type
- Transcription factor PU.1
- Excitatory amino acid transporter 1
Sequence:
MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG
Protein: Protein SST2 (P11972)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Desensitization to alpha-factor pheromone. Is involved in regulating the signaling pathway for responding to mating pheromone.
Interaction partners:
- Guanine nucleotide-binding protein alpha-1 subunit
- Guanine nucleotide-binding protein subunit beta
- Pheromone alpha factor receptor
- Guanine nucleotide-binding protein alpha-2 subunit
- Cyclin-dependent kinase inhibitor FAR1
- Mitogen-activated protein kinase FUS3
- Nuclear fusion protein FUS1
- Regulator of G-protein signaling 2
- Barrierpepsin
- Pheromone a factor receptor
Sequence:
MVDKNRTLHELSSKNFSRTPNGLIFTNDLKTVYSIFLICLDLKEKKHSSDTKSFLLTAFTKHFHFTFTYQEAIKAMGQLELKVDMNTTCINVSYNIKPSLARHLLTLFMSSKLLHTPQDRTRGEPKEKVLFQPTPKGVAVLQKYVRDIGLKTMPDILLSSFNSMKLFTFERSSVTDSIIHSDYLIHILFIKMMGAKPNVWSPTNADDPLPCLSSLLEYTNNDDTFTFEKSKPEQGWQAQIGNIDINDLERVSPLAHRFFTNPDSESHTQYYVSNAGIRLFENKTFGTSKKIVIKYTFTTKAIWQWIMDCTDIMHVKEAVSLAALFLKTGLIVPVLLQPSRTDKKKFQISRSSFFTLSKRGWDLVSWTGCKSNNIRAPNGSTIDLDFTLRGHMTVRDEKKTLDDSEGFSQDMLISSSNLNKLDYVLTDPGMRYLFRRHLEKELCVENLDVFIEIKRFLKKMTILKKLIDSKHCDKKSNTSTSKNNIVKTIDSALMKQANECLEMAYHIYSSYIMIGSPYQLNIHHNLRQNISDIMLHPHSPLSEHFPTNLYDPSPASAESAASSISSTEADTLGEPPEVSLKPSKNLSNENCSFKKQGFKHQLKEYKPAPLTLAETHSPNASVENSHTIVRYGMDNTQNDTKSVESFPATLKVLRKLYPLFEIVSNEMYRLMNNDSFQKFTQSDVYKDASALIEIQEKC
Protein: Thoeris anti-defense 2-like domain-containing protein (A0A0H2UPC2)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MKNVELKEKNMTFEEILPGLKAKRKYVRTGWGGAENYVQLFDTIEQNGLALEMTPYFLINVSGEGEGFSMWSPTVCDVLATDWVEVHD
Protein: Putative mannan endo-1,6-alpha-mannosidase C1198.07c (EC 3.2.1.101) (Endo-alpha-1->6-D-mannanase C1198.07c) (Q9P6I3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass type I membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable glycosidase C21B10.07
- Uncharacterized protein C19C7.05
- Probable lipase C14C8.15
- Uncharacterized membrane protein C30D10.09c
- Uncharacterized membrane protein C18H10.18c
- Uncharacterized protein C594.02c
- SUR7 family protein pun1
- Autophagy-related protein 17
- TBC domain-containing protein C23D3.03c
- Autophagy protein 13
Sequence:
MRYLSFFFEFFFLFSFAFAFDFDVTSDDSINSALTTVTDGMLNYYQSTSHTFTAYWWMTGAGLNSMTDTYAATGNTTHLDMLISALVANKGDNNDYAPNSEKFDLGNDDQGIWGLSAMSAAEVNMTTGDSSASFTELAQAVFNEIMSRWDTSSCGGGVRWQIYSFNNGYSYKNSISNGILFQLAARLARYTNNDTYVDLAQKVWDWSTTVGFVDLDDYTVYDGASVTSNCSSITNEQWSYNVGVYLAGTAFLYNYTNGSSVWQTHMEGLMNKALDYYFTSDKIIYEPSCEPTESCNSDQTAFKGMLARFLGYTMQLAPYTVETILPYIQSSAEAAALACSGGSDGVTCGYMWYWNNGTWDDHYGLGEQISAVETFQALLAQQSATILTLDTGASSESNPDAGTDDGDTVTITPATKSDKGWAGFLTFAFSFVFLLFSIWLYF
Protein: E3 ubiquitin-protein ligase SIAH1B (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1B) (Seven in absentia homolog 1b) (Siah-1b) (Siah1b) (Q06985)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.
Interaction partners:
- Calcyclin-binding protein
- Catenin beta-1
- Axin-1
- E3 ubiquitin-protein ligase SIAH1A
- Adenomatous polyposis coli protein
- Ubiquitin carboxyl-terminal hydrolase 19
- Glycogen synthase kinase-3 beta
- Dapper homolog 1
- Beta-catenin-interacting protein 1
Sequence:
MSRQAATALSTGTSKCPPSQRVPALTDTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAVEKVANSVLFPCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
Protein: IQ motif and SEC7 domain-containing protein 3 (Q9UPP2)
Organism: Homo sapiens (Human)
Function: Acts as a guanine nucleotide exchange factor (GEF) for ARF1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17981261}. Postsynaptic density {ECO:0000250|UniProtKB:Q3TES0}.
Interaction partners:
- RNA binding protein fox-1 homolog 3
- Gephyrin
- ADP-ribosylation factor 6
Sequence:
MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRERIDELERRLDELSAENRSLWEHQQLLQAQPPPGLVPPSSAPLPAAPATAPAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQHHGQLLEQPQRGPGSRAHTPQSPHKHLGTQGAVTDKEKERPPSCCAAAGALLQHKSPSALGKGVLSRRPENETVLHQFCCPAADACSDLASQSDGSCTQAGGGMEDSVVAAAAVAAGRPSAHAPKAQAQELQEEEERPGAGAASPRAGPQHKASPGRQQPALATALCPHAPAASDYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPTAESLAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSPTAKREAALRERPAESTVEVSIHNRLQTSQHNSGLGAERGAPVPPPDLQPSPPRQQTPPLPPPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYTSSSSDSCGSTPLGGPGSPVKVTHQPPLPPPPPPYNHPHQFCPPGSLLHGHRYSSGSRSLV