wanglab/gogpt-training-data huggingface dataset:
Protein: J domain-containing protein (P91189)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
- Protein disulfide-isomerase A6 homolog
- Heat shock 70 kDa protein C
- LRRCT domain-containing protein
- Endoplasmic reticulum chaperone BiP homolog
- Glycerol kinase
- Protein kinase domain-containing protein
- Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein
- Saposin B-type domain-containing protein
- Endoplasmin homolog
- Heat shock protein hsp-6
Sequence:
MTIYQHLLILWSSLFASTFAGTAEEVAKHLELGSQFLARAQFADALTQYHAAIELDPKSYQAIYRRATTYLAMGRGKAAIVDLERVLELKPDFYGARIQRGNILLKQGELEAAEADFNIVLNHDSSNNDVQEKTALIEQHRQLRHQIKSAYAGGDCATVEEYINHIIEIQVWDASLYRMRAKCLEERGELKKAIHDMRIVSKLSTDSTDTMFETSKLLYTVGDLEESLNVIRECLKLNPDHKSCYPFYKKLRKVVKSLESMKKKVENSDWMACLEEGQKTMKFDPTPSVQLNVFRITNRCQREAGHISEAIAECNEILNDDPSDADILCERAEAHILDEDYDSAIEDYQKATEVNPDHREAKEGLEHAKRLKTQAGKRDYYKILGVKRNASKREITKAYRKLAQKWHPDNFSDEEEKKKAEKKFIDIAAAKEVLQDEEKRRQFDQGVDPLDPEAQRQGGGHHGGFGHGFPHGFHHFGGGGGGEHSFKFNWG
Protein: Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) (O74890)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative leucine--tRNA ligase, cytoplasmic
- Putative leucine--tRNA ligase, mitochondrial
- Isoleucine--tRNA ligase, mitochondrial
- Isoleucine--tRNA ligase, cytoplasmic
- Tyrosine--tRNA ligase, cytoplasmic
- Valine--tRNA ligase
- Probable cysteine--tRNA ligase
- Tryptophan--tRNA ligase, cytoplasmic
- Tryptophan--tRNA ligase, mitochondrial
- NEDD8-activating enzyme E1 catalytic subunit
Sequence:
MSRLLACLKQLQARSLIHNTTLLQPSCNVNSVYLGADPTAASLHVGNLVALMPLVHFFLNGFPVFTVIGDATAQLGDPSGRSTSRKQMAETTRTANSNSIHNQLKDLSSSILSYAQDCNYPFSQMPSSSQWSIVRNSSWYENLKLLKFLSSVGPHVRVSQMLARDSVTTRLQSPSGLSFAELTYQLLQAYDYSYLYENHSVNLQIGGSDQWGNITAGTDLVRRTHPNANVYALTTPLLTSSSGQKLGKSAGNAIWLDPKLTDSYSLYQYFISAPDDLACKCLDMLTLLPLEQLEQIKAEHEKDPSQRIVHKYLASNVVRMVHGKKALELAQIQTKLLHGAHQAPFGFYSEAPQQGDSFPSLPEIRALFKDCKFYRTIDSSIKDQPFSRLLRTLQIYTSRKEATEHILSGAVSLGHKPILDSNYKFPDNSLFVLRAGKRTFVLDSL
Protein: Nitrogen regulatory IIA protein (PTS IIA-like nitrogen regulatory protein PtsN) (A0A0H3NI89)
Organism: Salmonella typhimurium (strain SL1344)
Interaction partners:
Sequence:
MINNDTTLQLSSVLNQECTRSGVHCQSKKRALEIISELAAKQLSLPPQVVFEAILTREKMGSTGIGNGIAIPHGKLEEDTLRAVGVFVQLETPIAFDAIDNQPVDLLFALLVPADQTKTHLHTLSLVAKRLADKTICRRLRAALNDEELYQIITDTEGEQNEA
Protein: V-type proton ATPase subunit a (V-ATPase a subunit) (Vacuolar ATPase 91 kDa subunit) (Vacuolar proton pump a subunit) (Vacuolar proton translocating ATPase subunit a) (O13742)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
Subcellular location: Vacuole membrane {ECO:0000250|UniProtKB:P32563}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- V-type proton ATPase subunit B
- V-type proton ATPase subunit d
- V-type proton ATPase subunit E
- V-type proton ATPase subunit F
- V-type proton ATPase subunit H
- Probable V-type proton ATPase 20 kDa proteolipid subunit
- V-type proton ATPase subunit D
- V-type proton ATPase subunit C
- V-type proton ATPase subunit c
- V-type proton ATPase catalytic subunit A
Sequence:
MSPSLFRSEEVSLVQLYLPTESARPIMSALGELSTIHFKDLNPDVVAFQRSFVREIRRLTDTERLLRYLHSEIDLNGIHVPDHNLPPSYESVLESSTIEDIIERITRLEARVRQLVESSQLLEARYLQQLEFANVLTKADAFFSKSGNTVDPLRNNYETSSIFSGEDDTTAPLIENALELGTTGTFDSEETSPQMNTTLDFVSGIIPTVKFQFLERILWRTLRGNLFIHQVRADDSLIHGAEKNEEKTIFLVIAHGTQILLRIRKISESLGATLFPVEEDAPGRTSQIQQANVSISDLNAVLENTRSALYTELTFIAEHISAWEAVLHKDKTVFQVMNLFNYDQNHKCLIAEGWCPTANLPMVQKTLRNISDLTDSQAPTILNVVHTSEQPPTYFRVNKFTEGFQSIIDSYGIATYREVNHGIVAIVTFPFLFAIMFGDLGHGAIMASVALMFVLYEKTLGAKKDLDEIVGMVFYGRYIVLLMGLFSMYVGFVYNDLFSKPMSIFSSRWVWPVKSEEAIARAVQVGTYPIGIDPTWHSADNNLLFMNSYKMKLSIILGVIHMTFCLFLSLSNYRFFKRKLDIYAVFVPSLIFLEAIFGYLVITIVYKWCIDWKAKDLQPPSLLNMLILMFLSPGTLEDQLYPGQKYLQVGLVIAALICVPWLLIVKPFVLWRRHSNEENKYQSLNSDLPNVDEADALMAVDSQEKQAEPFELGEVVIHQVIHTIEFCLGCVSHTASYLRLWALSLAHNQLSSVLWNMTLANGFRMTGIVGSIFVVILFGFWFIATCVVLVAMEGTSAMLHSLRLHWVEGMSKHFEGEGYAFTPFTFKVTAE
Protein: HscB mitochondrial iron-sulfur cluster cochaperone (J-type co-chaperone HSC20, isoform CRA_c) (B0QYH2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWRGRAGALLRVWGFWPTGVPRRRPLSCDAASQAGSNYPRCWNCGGPWGPGREDRFFCPQCRALQAPDPTRDYFSLMDCNRSFRVDTAKLQHRYQQLQRLVHPDFFSQRSQTEKDFSEKHSTLVNDAYKTLLAPLSRGLYLVS
Protein: NPL4-like protein 2 (O82264)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.
Interaction partners:
- Putative ubiquitin-dependent proteolytic protein
- AT2G21270 protein
- At2g29070
- Cell division control protein 48 homolog A
- Cell division control protein 48 homolog E
- Cell division control protein 48 homolog D
- AT5G65740 protein
- DNA excision repair protein ERCC-1
- AT3g18860/MCB22_3
- DNA repair endonuclease UVH1
Sequence:
MMMLRIRSRDGLERVTAEGAHITVSQLKTLIADQLQIPLHKQTLSTNRDLLLAKTPADLLAFTDLTDPNLPLSSLNLGHGSMLYLAYDGERSIPGAPPVTPAGSFGRKMTVDDLIARQMRVTRQETSHCDSVSFDRDAANAFQHYVNESLAFAVKRGGFMYGTVTEEGQVEVDFIYEPPQQGTEANLILMRDADEEKRVDAIAMGLGMRRVGFIFNQTVVQDKTEYTLSNAEVLQAAELHAESELKEWVTAVVKLEVNEDGGADVHFEAFQMSDMCIRLFKEEWFETEIMPDDDPKLSKMKKEVVVGVKDLKEVDNDFFLVLVRILDHQGPLSSTFPIENRSSRATMRALKTHLDRAKSLPLVKKMSDFHLLLFVAQFLDVSSDVPALAECVRLQSPVPEGYALLIESMANTC
Protein: RNA polymerase sigma factor sigE, chloroplastic/mitochondrial (Sigma factor E) (Sigma-E) (RNA polymerase sigma factor sig5) (Atsig5) (Sigma factor 5) (Q9ZNX9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein. Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites (e.g. psbA and psbD) and are then released. Essential for blue light-mediated transcription of psbD, which encodes the photosystem II reaction center protein D2. Plays a role in reproduction. Required during female gametophyte development.
Subcellular location: [Isoform 1]: Plastid, chloroplast.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:21123745}.
Interaction partners:
- Small ribosomal subunit protein uS9m
- Photosystem II D2 protein
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- Phytochrome-interacting ankyrin-repeat protein 2
- DNA-directed RNA polymerase subunit alpha
- Large ribosomal subunit protein bL28c
- Photosystem II protein D1
- 50S ribosomal protein L33
- DNA-directed RNA polymerase 3, chloroplastic
Sequence:
MGVVSISSSAARSPLGLGNDLLTHRSSLKKPSIVAFKADDSSNSALIIPPREQVLIPAEKHNEKKREVTRRKPCKTPKKPLSLEHNSAPSCSLGVDYNEAAARLESIYKLSPATTTLVEDDVEDGGSKAKVSRRRKRKESGEEKKVVVRNNVKKEKRMSLDKRIALKRNVQEKPVVASVDKKVTKRQQEEEKIERLVRDYSASNDIVSLDWKKMKIPPVLSSTEHAWLFKLMQPMKALLEVKDVLQKSLGREPREAEIAGEINMTAGEVKKKIEIGRAARNKLIKHNLRLVLFVMNKYFHEFTNGPKFQDLCQAGMRGLITAIDRFEPKRKFRLSTYGLFWIRHAIIRSMTTSNFTRVPFGLESVRVEIYKAKTELWFEMGRPPTEDEVVERLKITPERYREVLRAAKPVLSLNSKHSVTQEEFINGITDVDGVGANNSRQPALLRLALDDVLDSLKPKESLVIRQRYGLDGKGDRTLGEIAGNLNISREMVRKHEVKALMKLKHQARVDYLRQYIV
Protein: Battenin (Q5U392)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Lysosome membrane {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361113}.
Interaction partners:
- Uncharacterized protein.
- CLN6 transmembrane ER protein a.
- Major facilitator superfamily domain-containing protein 8
- Palmitoyl-protein thioesterase 1
- 3-hydroxy-3-methylglutaryl-CoA lyase.
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
- Tripeptidyl-peptidase 1
- Cathepsin D
- Cathepsin F
Sequence:
MDRSVNSGTASTSDTEGRCQRWRNCVAFWLLGLCNNFAYVVMLSAAHDILQKQESQNTTAPSPAPNGTNIEFRNSSNSSRYDCNPVSTAAVLLADILPTLLIKLTAPFYIHKVPYGFRVLVCFFTAVVSFLMVSFSSTISMSIIGVIFASVSSGLGELSFLSLSVFFSSDVLSGWGSGTGAAGVAGALLYSALTQAGLTPQVTLWIMLVVPVILAVSYFVLLVFPHSFPQWRCPEVSQSLSRGLNSEERRALIEEDTDTDEDSEPALEDQDDKHIGPLTFTEKKYIIKGLLKFIFPLALVYFAEYFINQGLMELLYFPDSRLSHAEQYRWYQTVYQIGVFVSRTSLFCFKIRKIFLMSLLQCANAVLLVFAVYYQFLPNISVVFVIIAFEGLLGGAAYVNTFFFIREESVEREREFAMATATVGDSLGIAFSAAAAFPVHHYFCSL
Protein: ATP-binding cassette transporter sub-family G member 2a (Broad substrate specificity ATP-binding cassette transporter ABCG2) (Q2Q447)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MADTRVELTGVLDLQNHVNTGVSSSPSRRGATVSFHNINYSLKMKSGFCKSKSTKKNILIGLNGIMKPGLNAILGATGSGKSSFLDVLAARKDPAGLSGEVLIDGAPQPPNFKCLSGYVVQDDVVMGTLTVRENLRFSAALRLPKSIKQREKDEKVERLIQELGLSKVADSRVGTQLIRGVSGGERKRTNIGMELIIDPPVLFLDEPTTGLDASTANSVLMLLKKMGNNGRTIILSIHQPRYSIYRLFDSLTLLVGGKLVYHGPAQDALSYFSQIGYTCEPHNNPADFFLDVINGDSSAVTLNKLYEEVDQDQLSSSLKGIEDRLVEEYQRSSIFQQTHADLQRIVQGQDYSTRPKSRTITYSTSFCHQFHWVLKRTFRNLMLNPQTSVAQIGVMIFLALVVGAIFFGVAENSSGIQNRMGALFFITTNQCFSSVSAAELFIAERKLFVHEYISGYYRVSVYFLSKILSDILTLRTIPAVIFSCVAYFMIGLKPAAEAFFIFLFSIIMVSYTATAMTLAISADQTVVAIANIFMTISFVFMMIFSGLLVNLPSVATWLNWLKYFSIPRYGLSALQINEFTGLFFCDNRNNSGSVCSSGEEFFQEQGIDYSAWGLWQNHLALGIMTFIFLCIAYLKLRFIKKFT
Protein: C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191) (P51675)
Organism: Mus musculus (Mouse)
Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P32246}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32246}.
Interaction partners:
- C-C motif chemokine 5
- C-C motif chemokine 9
- C-C motif chemokine 3
- C-C motif chemokine 7
- C-C motif chemokine 4
- C-C motif chemokine 2
- C-C motif chemokine 8
- C-C motif chemokine 6
- Eotaxin
- C-X-C motif chemokine 10
Sequence:
MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTHRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF
Protein: DExH-box ATP-dependent RNA helicase DExH14 (EC 3.6.4.13) (BRR2 homolog C) (AtBRR2C) (Pre-mRNA-splicing helicase BRR2C) (Q9FNQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-processing-splicing factor 8A
- Pre-mRNA-processing-splicing factor 8B
- Protein STABILIZED1
- ATP-dependent RNA helicase DEAH12, chloroplastic
- Transcription regulator/ zinc ion binding protein
- Cwf15 / Cwc15 cell cycle control family protein
- Pre-mRNA-splicing factor 18
- Small nuclear ribonucleoprotein Sm D2
- Nuclear protein-like
- Probable small nuclear ribonucleoprotein F
Sequence:
MVHNSPCNKHKTTSISWTRILAGRCTGLFVQVSNRRRFRTQAIAFFLGEPTRGENTTEEKNPKRHKYRDFVMLVQLPRLTSSLREPFDIDQAYLRRKTILQTLNKPRSSGNRLDESDLAKRIVHQWEGASLEVRQAYKQFIGAVVELIDREVPSDEFREVAFSAYRLFNNPVEEDDSDINDNISISGKKLELQNLVGHAVSDANVKNVASFAQALYSIQPTHQSETYADEVNGGAEFGADLVFNLPARFLVEASLDETGFVDVESNDAHTSFSEGWSGVSDTKNNLSAGKFNLSWLRDACGRMVRETNSQLSREELAMAICRFLDSDKPGEEIAGDLLDLVGDGAFETVQDLIMHRKEIVDAIHHGQMILKSDKAASNTQSRMPTYGTQVTVQTESAKQIEKLRRKEEKKNKRNADLGLESEISEANFSSLLEASEKKTAFEDLIGSGEANSLALALPQGTVRKHLKGYEEVFIPPTPTAQMKPGEKLIEIKELDDFAQAAFHGYKSLNRIQSRIFQTVYHTNENILVCAPTGAGKTNIAMISVLHEIKQHFRDGYLHKNEFKIVYVAPMKALAAEVTSAFSRRLAPLNMVVKELTGDMQLTKTELEETQMIVTTPEKWDVITRKSSDMSMSMLVKLLIIDEVHLLNDDRGAVIEALVARTLRQVESTQTMIRIVGLSATLPSYLQVAQFLRVNTDTGLFYFDSSYRPVPLAQQYIGITEHNFAARNELLNEICYKKVVDSIKQGHQAMIFVHSRKDTSKTAEKLVDLARQYETLDLFTNETHPQFQLMKKDVMKSRNKDLVKFFEAGFGIHHAGMLRSDRTLTERLFSDGLLKVLVCTATLAWGVNLPAHTVVIKGTQLYDAKAGGWKDLGMLDVMQIFGRAGRPQFDKSGEGIIITSHDKLAYYLRLLTSQLPIESQFISSLKDNLNAEVVLGTVTNVKEACAWLGYTYLSIRMKLNPLAYGIGWEEIIADPSLSLKQRALVADAARSLDKAKMMRFDEKSGNFYCTELGRVASHFYIQYSSVETYNEMLKRHMNESEIINMVAHSSEFENIVVREEEQHELETLARSCCPLEVKGGPSNKHGKISILIQLYISRGSIDAFSLVSDASYISASLARIMRALFEICLRKGWCEMTLFMLEYCKAVDRQLWPHQHPLRQFERDLPSDILRKLEERRDDLDHLYEMEEKEIGALIRYNPGGRLVKQHLGYFPSIQLAATVSPITRTVLKVDLLITPNFIWKDRFHGTALRWWILIEDTENDYIYHSDLFTLTKRMARGEPQKLSFTVPIFEPHPPQYYVHAVSDSWLHAETYFTISFHNLALPEARTSHTELLDLKPLPVTSLGNKLYESLYKFSHFNPIQTQIFHVLYHTDNNVLVGAPTGSGKTISAELAMLRLFSTQPDMKVVYIAPLKAIVRERMNDWKKHLVAPLGKEMVEMTGDYTPDLVALLSADIIISTPEKWDGISRNWHTRSYVKKVGLVILDEIHLLGADRGPILEVIVSRMRYISSQTERSVRFVGLSTALANAGDLADWLGVGEIGLFNFKPSVRPVPIEVHIQGYPGKYYCPRMNSMNKPAYAAICTHSPTKPVLIFVSSRRQTRLTALDLIQFAASDEHPRQFLSVSEEDLQMVLSQITDQNLRHTLQFGIGLHHAGLNDHDRSAVEELFTNNKIQVLVSTSTLAWGVNLPAHLVIIKGTEYFDGKTKRYVDFPLTEILQMMGRAGRPQFDQHGKAVILVHEPKKSFYKKFLYEPFPVESSLKEKLHDHFNAEIVSGTIGNKEDAVHYLTWTYLFRRLMANPAYYGLEGTQDETICSYLSRLVQTTFEDLEDSGCLKVNEDSVEPTMLGTIASQYYLCYMTVSMFGSNIGPDTSLEAFLHILAGASEYDELPVRHNEENYNKTLSDRVRYPVDNNHLDDPHVKANLLFQAHFSQLALPISDYNTDLKSVLDQSIRILQAMIDICANSGWLSSSLTCMRLLQMVMQGMWSDQDSSLWMIPCMNDLLLGSLTARGIHTLHQLLNLPRETLQSVTENFPASRLSQDLQRFPRIQMNVRLQKKDSDGKKKPSTLEIRLEKTSKRNSSRALAPRFPKVKDEAWWLVLGDTSTSELFAVKRVSFTGRLITRMELPPNITSFQDTKLILVSDCYLGFEQEHSIEQLARRG
Protein: Isoflavone reductase homolog P3 (EC 1.3.1.-) (P52577)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- RING-H2 finger protein ATL48
- Small ribosomal subunit protein uS19y
- Probable quinone oxidoreductase
- Methionine aminopeptidase 1A
- non-specific serine/threonine protein kinase
- Large ribosomal subunit protein uL11x
Sequence:
MATEKSKILVIGGTGYIGKFLVEASAKAGHSTFALVREATLSDPVKGKTVQSFKDLGVTILHGDLNDHESLVKAIKQVDVVISTVGSMQILDQTKIISAIKEAGNVKRFLPSEFGVDVDRTSAVEPAKSAFAGKIQIRRTIEAEGIPYTYAVTGCFGGYYLPTLVQFEPGLTSPPRDKVTILGDGNAKAVINKEEDIAAYTIKAVDDPRTLNKILYIKPSNNTLSMNEIVTLWEKKIGKSLEKTHLPEEQLLKSIQESPIPINVVLSINHAVFVNGDTNISIEPSFGVEASELYPDVKYTSVDEYLSYFA
Protein: Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) (Q8BGC3)
Organism: Mus musculus (Mouse)
Function: Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q6ZSM3}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:26376857}; Multi-pass membrane protein {ECO:0000255}. Note=Interaction with isoform 2 of BSG is required for its localization to the plasma membrane. {ECO:0000250|UniProtKB:Q6ZSM3}.
Interaction partners:
Sequence:
MTKITRVSLASPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDRSVPEKNHNRESQREDCKQASPYSPLTKECTETRLCCSLQQEYGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVRIVKRMKRTQVPFPVKDSDPKLQLWTNGSVAYSVARELDQKDEEPLPKARSGCNLT
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A8JR46)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- X-box-binding protein 1
- Endoplasmic reticulum chaperone BiP
- Cytoplasmic aconitate hydratase
- Cytoplasmic aconitate hydratase
- Atf6, isoform C
- Uridine 5'-monophosphate synthase
- E3 ubiquitin-protein ligase HRD1
- RE14391p
- Eukaryotic translation initiation factor 2 subunit 1
- Cryptocephal, isoform A
Sequence:
MRFCVVVCCVLFLLASGLIASATAKSQQGDSAEVVSSGEDEKTDCTDLARDEEALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLGQMGSLKKLPYTIPQLVANAPCRSSDGILYSGKKSDTWYMVDPKTGRREKVMGFGDATVDGKEGEQIGWATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIVTLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAILEESKTGNVNTVKLFQSLYVGEHQKGLYALPSLVDKNTPRISTAPPIKLLDGPTGDQNSNQETDPRTIYINDVLQEHAGIMLGHYNMPNEGNGNLQLSPTTASSKVVQSLATIHNYNDGYGLLANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSNKVQAFINEWFMEHPSGKVHQILIVIVLGMIALFWYTCSTMRELQKQSENGSKTFAIAQNGSNGSTGSNGSNANAEDLVDLGNGQVRVGKISFSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMRSQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLDDWNVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSICSNEPIFKPYYSAGYLFTRPWYFDADDALFPMLMLDPKPLPKIGSPKKTPSPASSQAQQLKQRKGLYNFRKPNDELPIPGVGLQRNLELDGQSLEPDGKRDVFANFKFRRYSKPGNNRNYNGGHKEAQDKEKYVIWTLPPSTQD
Protein: Phosphate regulon transcriptional regulatory protein PhoB (P23620)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.
Subcellular location: Cytoplasm.
Interaction partners:
- Phosphate regulon sensor protein PhoR
- Phosphate-specific transport system accessory protein PhoU homolog
- Phosphate-binding protein PstS
- Phosphate import ATP-binding protein PstB
- Alkaline phosphatase L
- histidine kinase
- Two-component sensor PhoQ
- Membrane protein component of ABC phosphate transporter
- Phosphate transport system permease protein PstA
- histidine kinase
Sequence:
MVGKTILIVDDEAPIREMIAVALEMAGYECLEAENTQQAHAVIVDRKPDLILLDWMLPGTSGIELARRLKRDELTVDIPIIMLTAKGEEDNKIQGLEVGADDYITKPFSPRELVARLKAVLRRTGPGDSEAPIEVGGLLLDPISHRVTIDGKPAEMGPTEYRLLQFFMTHQERAYTRGQLLDQVWGGNVYVEERTVDVHIRRLRKALGEVYENLVQTVRGTGYRFSTKS
Protein: Elongation factor 1-alpha, putative (Q38DU6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosomal RNA-processing protein 43
- Protein pelota homolog
- RNasePH-like protein exosome-associated protein 1 Rrp42 homologue
- Exosome component CSL4
- Exosome complex exonuclease RRP40
- Ribosomal RNA processing protein 45
- Ribosomal RNA processing protein 4
- 40S ribosomal protein S23, putative
- 40S ribosomal protein S15, putative
- Small ribosomal subunit protein uS5
Sequence:
MNRHRKFYNELDDYMDDDYYEEEDYYYEEGEGYYGGEEAQQPAGVSRTDNLEGQKPEESDIHRLDKQDVDYELLQTLLPGFYEQLLTTNGTCRCDTPRAVEALRACNYDVCQAVSAVTSTVVRPAVSTPIPGKGRSLKVGSTAKRETSMTASTKEQIGAAVDFSPSSAQLQQQRQQQQQQHKGKKDMVKEIAPDPSKLDCTFIVAGHVDAGKSTTIGHLLLMLGKVTQSEVDRNEKNARQMKKESFKFAWLLDQSEEERRRGVTIDAGSYCFETEHRRIHVLDAPGHKDYVLNMMSSAAQADAALLVVTAGTSEFEVGLAHGTKEHLVILKMLGVGHIVVAVNKMDSVGYSQERYDFVVRELKYLLKQVHFKEDAVAGFCPVSGIQGTNINVVDVGLTPWYKGPSLVVLLDQCPLESRMMGTLLRLSVQDVQDSRIFCKVECGNVQKGEKLLFVPADVKVQVRSIEKPTMGGLVPAAFAGDTIVIDTASSLVGLGPGCVGCKAGSGDATRCSTDFKARIQTYTTLQKSILPGARFTMVCHALTVQLQVLVLVSKMDRCGNWSSGMVKCIPKSTQAIIVFRAERKVALEPAEVCRSLGRFVLQQDGETVAGGLVESIML
Protein: D-lactate dehydrogenase [cytochrome], mitochondrial (AtD-LDH) (EC 1.1.2.4) (D-lactate ferricytochrome C oxidoreductase) (Glycolate dehydrogenase) (Q94AX4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the stereospecific oxidation of D-lactate to pyruvate. Involved in the detoxification of methylglyoxal and D-lactate, but probably not involved in the metabolization of glycolate.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14966218}.
Interaction partners:
- Hydroxyacylglutathione hydrolase cytoplasmic
- Probable hydroxyacylglutathione hydrolase 2, chloroplastic
- Hydroxyacylglutathione hydrolase 2, mitochondrial
- NADP-dependent malic enzyme 3
- Hydroxyacylglutathione hydrolase 1, mitochondrial
- NADP-dependent malic enzyme 4, chloroplastic
- NADP-dependent malic enzyme 1
- NADP-dependent malic enzyme 2
- Plastidial pyruvate kinase 2
- L-lactate dehydrogenase
Sequence:
MAFASKFARSKTILSFLRPCRQLHSTPKSTGDVTVLSPVKGRRRLPTCWSSSLFPLAIAASATSFAYLNLSNPSISESSSALDSRDITVGGKDSTEAVVKGEYKQVPKELISQLKTILEDNLTTDYDERYFHGKPQNSFHKAVNIPDVVVFPRSEEEVSKILKSCNEYKVPIVPYGGATSIEGHTLAPKGGVCIDMSLMKRVKALHVEDMDVIVEPGIGWLELNEYLEEYGLFFPLDPGPGASIGGMCATRCSGSLAVRYGTMRDNVISLKVVLPNGDVVKTASRARKSAAGYDLTRLIIGSEGTLGVITEITLRLQKIPQHSVVAVCNFPTVKDAADVAIATMMSGIQVSRVELLDEVQIRAINMANGKNLTEAPTLMFEFIGTEAYTREQTQIVQQIASKHNGSDFMFAEEPEAKKELWKIRKEALWACYAMAPGHEAMITDVCVPLSHLAELISRSKKELDASSLLCTVIAHAGDGNFHTCIMFDPSSEEQRREAERLNHFMVHSALSMDGTCTGEHGVGTGKMKYLEKELGIEALQTMKRIKKTLDPNDIMNPGKLIPPHVCF
Protein: TATA box binding protein (Q66HB1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Transcription initiation factor IIB
- TATA-box binding protein associated factor 4
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor IIA subunit 1
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 11
- General transcription factor IIF subunit 2
Sequence:
MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPVQNTNSLSILEEQQRQQQQQQQQQQQQQQQAVATAAASVQQSTSQQPTQGASGQTPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT
Protein: Transient receptor potential cation channel, subfamily C, member 7 (A0A8I6GIF7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLGSNTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSVFVASFTARFMAFLKASEAQLYVDQYVQDVTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKRCENDLEMGMLNSKFRKTRYQAGMRNSENLTANSTFSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI
Protein: GH09291p (Q95U41)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPPQNEVIIVSNDMNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSSTVHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSNELVKRQPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVRGRRGIEVLVGGSGGSDVDSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSLTNNHNHETIDEEEEVVIRPKARVPAVVKSANAQGLTKEEIELRNLRKKTRKRTRKFEIDGVQMTTTTSRVIYGDDENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQDRRFEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIRLLKQEVDLFPKDKRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATINRNFLQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRMLQRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRYMQEERRFEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQLVPRKQVCMQIPV