wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q580Q1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Flagellar attachment zone protein 1 conserved domain-containing protein
Sequence:
MEVEDFMAVSPSTVVELNVSPDSSMKIVDYSHRHSLVISDRASSPNSRHSGRVSCRSSVRDEAQTSDELFRKQRVVRCMQIERERAARSKMERAEHDDWLRLRSVERSEVVKHMTDEQIVELLQREAREIERERLEAEEAIRRGVEEAAARQRQRTSQNLNNRSSTEFSHRGGQRPLASDIANRTCTDSGDTVGDRMRASADIKSVTKLLGPQRAGTEAGSKALTKPSTAAVGKFPQALATAADVHLTSGDKLTPKGSTTHVRGDEPPGANNSATTTTAPVTDVATSTRSRPERLSDIVTKLQRAQEDALALRGEMKSLKQAQQEAEMRFRVESERADNEAKAKRMFAKRADTYKASVEELQRKTAEVEAELRTLRQRETRNQTMQKVKDELKMATEQIRALEEENKDLKDRQQELYNENARLSSNVRRISGASQGELLPEFEGIFEGVSGDMNASGSEMGNTGQDREALGSFVVKYNMLVDQFEELQRQSAEQQLEIQRIISENKGLKNRSQGQPPAASKRQPVSEATVRSEGASGDGKEMEHLRWEARKYKQEAIETRKELKALKESSENEISSLKEWCERLKVKCKRQTDDIKKYMSQNKAVDATKGETKEKSPDTAEDVDGAKAACAAEVGRLQDEILQLRSRLSESTKKEQAAISLAESLKREKVDPYSRDKRKEEELQRQVDTLTRTVKERREAEARWKESQQATENELKSLLAELTASHKTIENLKHEVSSLREEQKACTPLKQEHSDENAELRSTVTAINTENEELREKIATLQKELEELRRRYIDLEREAEERNANAQKEINELRRENENLRRPPATKVNSNKCCQ
Protein: Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) (X2JKM9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|HAMAP-Rule:MF_03022}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000256|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|HAMAP-Rule:MF_03022}. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles. {ECO:0000256|HAMAP-Rule:MF_03022}.
Interaction partners:
Sequence:
MALPRKLISKIYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGISVIGWEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISLDRVIPFYQPPNSLPNFKHNSTNRKSFTRGNQKFRLSVGGAKPAQVQEEHEGDKSGLSSPNYSLEVVNEAVLESAETSPMSSLPPVHLASMAGSSADLAPHHVVYGGAIDSALRQGKYSRVPDNMASYGSSYGAIDTRLMSLNEPSSLHKPDIYNLYPLDKNEEADVQQLEFNLNDSNPPILNNYDNYEMAEDFPVNQNLNYITNNYKPVPATSTINASSKSIKKTTTTTLHKRTTNNMAGAKQTSTGIFGGSKLSQVSSVSSMELHKLDDNMVLKKSSSSNVVNKNKRPMGSAQSQFSKENNQQKNINVEIITKPPMRSRTTLDMRTSHQAKTQEKQIHQQPMNNRIIMDDHDFDMLSRSHEAVLQELSNRQSSLDLLRHATRSHDVLGALRQARSCGKSIFIDLLGAILEKPSSWNLDFCMFVLPEIYELLQSQHKFHFTRACDTLRIILSNFLPTIQENLDSWAANGLGVDVTREDRQRKCAECQRWLLQIKNLPESTHFGSTLSQLQNIIIF
Protein: Breast carcinoma-amplified sequence 4 (Q8TDM0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- BCAS3 microtubule associated cell migration factor
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- SNARE-associated protein Snapin
- Dysbindin
Sequence:
MQRTGGGAPRPGRNHGLPGSLRQPDPVALLMLLVDADQPEPMRSGARELALFLTPEPGAEAKEVEETIEGMLLRLEEFCSLADLIRSDTSQILEENIPVLKAKLTEMRGIYAKVDRLEAFVKMVGHHVAFLEADVLQAERDHGAFPQALRRWLGSAGLPSFRNVECSGTIPARCNLRLPGSSDSPASASQVAGITEVTCTGARDVRAAHTV
Protein: Tripartite motif-containing 25 (Q6P7B3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAELFPLAEELSCSICLEPFKEPVTTPCGHNFCRSCLNETWVVQGPPYRCPQCRTVYQVRPQLHKNTVLCAVVEQFLQAEQARTPVDDWIPPTRSAASSSDTQVSCDHCLKEVAVKTCLVCMASFCQEHLRPHIDSPAFQDHPLQPPVRDLLRRKCSRHNRLREMFCPEHGECICHICLVEHKTCSPTILSQASADLENKLRQKLTIMYSHINGASKALEDVKSKQQNVQESMKRKMLQLRQEYLEMKAVIDAAETSSTHKLKEEEKRVYGKLDTIYQVLLKKKNEMQNLKAEVELILAKGDEFEFLEKAAKLQEVSTKPVYIPKIDLDHDLIKGVYQGALDLKSELKLSLKQLQEKKAEEPCNSGNVGDHAQSTSKPTRPAKKTAPDKKTKKTPGAAGAAGAAGAAGAAGPTSYSSSSNKLPTFGAPGQATIPDATLKPNAPQPNSAAVKAKVLENFLTMSRTELLEYFVKVVFDYNTAHNKVALADNYTTASVADGLQHYRSHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGVCYGSMDRQGPESRLGRNPSSWCVEWFNNKISAWHNNMEKTLPSTKATRVGVLLNCDHGFVIFFAVTEKVYLMYKFKVDFTEALYPAFWVFSAGTTLSICSK
Protein: N-(5'-phosphoribosyl)anthranilate isomerase (PRAI) (EC 5.3.1.24) (P43073)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Tryptophan synthase
- Multifunctional tryptophan biosynthesis protein
- Anthranilate phosphoribosyltransferase
- Imidazoleglycerol-phosphate dehydratase
- anthranilate synthase
- Orotidine 5'-phosphate decarboxylase
- 3-isopropylmalate dehydrogenase
- aminodeoxychorismate synthase
- Alpha-aminoadipate reductase
- Phosphoribosylaminoimidazole carboxylase
Sequence:
MKVVKICGIKTVEAASVAIDNGANLLGCILVPNRARTIDLEVAKQIARMVKRDRNPPPKFAGGTSTQHFEQVAQWIIENGPFLVGVFRNQPKEEVFRIAREVGLDFIQLHGSEDKLEFLGTEFGLIPRYVVPDELDLLEEQSLSLTQCVSLPLLDSEVGGEGKLLDWTFIEKLPTKAILAGGLTPENLPTFDNILGYDVSGGVETNGVKDSLKIIKFIQKGHAQSS
Protein: Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) (P51141)
Organism: Mus musculus (Mouse)
Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15353129}; Peripheral membrane protein {ECO:0000269|PubMed:15353129}; Cytoplasmic side {ECO:0000269|PubMed:15353129}. Cytoplasm, cytosol {ECO:0000269|PubMed:15353129}. Cytoplasmic vesicle {ECO:0000269|PubMed:15353129}. Note=Localizes at the cell membrane upon interaction with frizzled family members.
Interaction partners:
- Axin-1
- Glycogen synthase kinase-3 beta
- Disheveled-associated activator of morphogenesis 1
- Low-density lipoprotein receptor-related protein 5
- Low-density lipoprotein receptor-related protein 6
- Prickle-like protein 1
- Prickle-like protein 2
- Vang-like protein 2
- Predicted gene 21981
- Proto-oncogene FRAT1
Sequence:
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNRDEAARTNGHPRGDRRRDLGLPPDSASTVLSSELESSSFIDSDEEDNTSRLSSSTEQSTSSRLVRKHKCRRRKQRLRQTDRASSFSSITDSTMSLNIITVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTIPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAITRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAIVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSMLKHGFLRHTVNKITFSEQCYYVFGDLCSNLASLNLNSGSSGASDQDTLAPLPHPSVPWPLGQGYPYQYPGPPPCFPPAYQDPGFSCGSGSAGSQQSEGSKSSGSTRSSHRTPGREERRATGAGGSGSESDHTVPSGSGSTGWWERPVSQLSRGSSPRSQASAVAPGLPPLHPLTKAYAVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
Protein: DNA replication factor Cdt1 (Double parked homolog) (DUP) (Q9H211)
Organism: Homo sapiens (Human)
Function: Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments. Potential oncogene (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:26842564}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:22581055}. Note=Transiently localizes to kinetochores during prometaphase and metaphase. {ECO:0000269|PubMed:22581055}.
Interaction partners:
- Origin recognition complex subunit 1
- Geminin
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM4
- Origin recognition complex subunit 4
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM2
- Origin recognition complex subunit 2
- DNA replication licensing factor MCM3
Sequence:
MEQRRVTDFFARRRPGPPRIAPPKLACRTPSPARPALRAPASATSGSRKRARPPAAPGRDQARPPARRRLRLSVDEVSSPSTPEAPDIPACPSPGQKIKKSTPAAGQPPHLTSAQDQDTISELASCLQRARELGARVRALKASAQDAGESCTPEAEGRPEEPCGEKAPAYQRFHALAQPGLPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEECNVGQIKTVYPASYRFRQERSVPTFKDGTRRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQKLVEHVKEHHKAFLASLSPAMVVPEDQLTRWHPRFNVDEVPDIEPAALPQPPATEKLTTAQEVLARARNLISPRMEKALSQLALRSAAPSSPGSPRPALPATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACARMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQTRAEEGL
Protein: Serine/threonine-protein kinase sid2 (EC 2.7.11.1) (Q09898)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Part of a signaling pathway. Required for initiation of medial ring constriction and septation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm.
Interaction partners:
- Maintenance of ploidy protein mob1
- Septum-promoting GTP-binding protein 1
- Septation initiation network scaffold protein cdc11
- Cell division control protein 15
- Septation initiation protein sid4
- Cell division control protein 7
- Cell division control protein 14
- Cell division control protein 16
- Tyrosine-protein phosphatase CDC14 homolog
- Serine/threonine-protein kinase plo1
Sequence:
MNRVNDMSPVEGDLGLQLSSEADKKFDAYMKRHGLFEPGNLSNNDKERNLEDQFNSMKLSPVASSKENYPDNHMHSKHISKLPIASPIPRGLDRSGELSYKDNNHWSDRSSTGSPRWENGSMNLSVEEMEKVVQPKVKRMATICQMFFLDHYFEQLHYLYTRKQRARLFEEQLLKEPDSRRDELVKRYNGRERVYLRKRRTRISHGDFQTITQVGQGGYGSVWLARKRDTKEIVALKIMNKSVLHKMDEIRHVLTERDILTTANSEWLVRLLYAFQDTSNIYLAMEFVPGGDFRTLLSNSGVLRDHHAKFYATEMFLAIDALHQLGYIHRDLKPENFLVGASGHIKLTDFGLSSGIISKKKIESMKIRLQEVNNVVVPERSMRERRQVFRTLLSQDPVYAHSVVGSPDYMAPEVLRGENYNHSVDYWSLGCIMYECLSGFPPFSGSNVNETWSNLKNWRKCFQRPHYDDPRDLEFNWRDDAWDFVCHCITDPKDRFCSLKQVMQHPYFSKIDWKNVRTAYRPPFVPDLNSEIDAGYFDDFTNENDMSKYKEVHEKQAAIANMVNTFNKPKRNAFIGFTFRHQKNSHPTSSSSALSSPLSAPSFGTLL
Protein: Anti-sigma-F factor antagonist RsfB (Anti-anti-sigma F factor RsfB) (P9WGE1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Positive regulator of sigma-F (SigF) activity. Binds to anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription.
Interaction partners:
- Multidomain regulatory protein Rv1364c
- Anti-sigma-F factor RsbW
- Anti-sigma-F factor antagonist RsfA
- GTPase Obg
- Uncharacterized protein Rv2240c
- Anti-sigma factor antagonist
- 6-phosphogluconate dehydrogenase, decarboxylating
- Putative anti-anti-sigma factor Rv2638
- Uncharacterized protein Rv1354c
Sequence:
MSAPDSITVTVADHNGVAVLSIGGEIDLITAAALEEAIGEVVADNPTALVIDLSAVEFLGSVGLKILAATSEKIGQSVKFGVVARGSVTRRPIHLMGLDKTFRLFSTLHDALTGVRGGRIDR
Protein: Probable ribonucleotide transport ATP-binding protein mkl (P9WQL5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known, could be involved in the transport of ribonucleotides.
Interaction partners:
- Conserved integral membrane protein YrbE1B
- Conserved integral membrane protein YrbE1A
- Conserved hypothetical integral membrane protein YrbE3A
- Conserved hypothetical integral membrane protein YrbE2B
- Conserved integral membrane protein YrbE4B. Possible ABC transporter
- Conserved hypothetical integral membrane protein YrbE3B
- Conserved integral membrane protein YrbE4A. Possible ABC transporter
- Conserved hypothetical integral membrane protein YrbE2A
- Mce-family protein Mce1A
- Possible Mce-family lipoprotein LprK
Sequence:
MRYSDSYHTTGRWQPRASTEGFPMGVSIEVNGLTKSFGSSRIWEDVTLTIPAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSIIIDGTDIIECSAKELYEIRTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLALVGLGGDEKKFPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTAYLSQLIMDINAQIDATILIVTHNINIARTVPDNMGMLFRKHLVMFGPREVLLTSDEPVVRQFLNGRRIGPIGMSEEKDEATMAEEQALLDAGHHAGGVEEIEGVPPQISATPGMPERKAVARRQARVREMLHTLPKKAQAAILDDLEGTHKYAVHEIGQ
Protein: Dynactin 150 kDa subunit (Q54VD6)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Dynactin subunit 2
- Dynactin subunit 4
- Dynein heavy chain, cytoplasmic
- Cytoplasmic dynein 1 intermediate chain
- Dynactin subunit 5
- Dynactin subunit 6
- Cytoplasmic dynein 1 light intermediate chain 1
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha
Sequence:
MSEEGKSLPPGTRVSINGKPELGLGTVKYCGMTKFSPGRWVGIELDSAAGKNDGTVQGERYFDCKPAHGLFVKPNMAVIVEEQPQTQTQPQPQQTSNIDDGIDDSKLMPAPITTPSKIAATSGIRPPSSTGIRPPSSLGKGRPSLTGSSSTTSSSSSSSSTTTTTTTPTSSIKKPSESGIRRPSTIPSSTTTTTSTTSTSPTSTSPLTSPPPEKKSEPSPPTTTTISPPPPTVVEPTPIEQPQPTPSKISRPPSSASSRPTGIPKPSGLKEPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPIITPNPTITTTTTPIPTPSTPLPPSTSNSITLTPPSTQKKQSKIIQGEDEEEEEEINDLLNKSLATERMNQAVQENIDKMMTTINDLKEDKNRSQEEINSLKDRLKEAVASKDKQIKENEKQIKENEKQIQQLEKTIAIKEKENENLLKTQHRNEDKEKSEFEKEKQSLLEQISNLNENLELLTLDKEVTEEKLEMTELEFEQVKEELEMMRIEYDSLKIQLDEKPTRSIDESLPTDVLVLQEQNDKLKEALVKLRDITMNDKHELSKKTKELETLSKQVQSLTEKSNKLEMELSIKIEETLELKLALEDAEVSESLITDLTDKNLSLNEELEELKVSIADLESFRDLSEELSENQVALEKSLRLEVNSKDIEILNIQSQMTNLQIKNQENEKTILQFRDLVGRLQHKLEEMRRKEEEQSEHQHSWSAIQQQLLSKNIQLQNQMIKATALEIDHQLEQSKSVESQVHLAFVYEYLPEQTFQLDNDAIKMLLLLKRIILKSELAQKYLNRTYKVEEIGNKVAGGDSDQMLLTSGQVAHSLSIIHILEHLAISTTWLTETLERSSSDQWLRSGRSIKDMLNQERILDNLLQLIKLEQFGSSYSSTDLEKLCQRIDSILTNIFGNITNSTNDSGSNNTSSNNNNNNNVDQIFKPEWSILLNYILGIQYNIKQIMLNDINITTTITHNDQFIFPHKEMSKVLSVCRKVVKNLLTKPYLSQSSIVRDLLKTSEHTCKSILLELVQSLPKIQDESINSGGGGSGSGSGNLNNNLNDLLIKIQARSDLIISNSNSLNKNNDEFSNDDYQDQEESKLSSSLEKVFYRMNVQLSDVVETIIAGDLNLSEKDKQALTKQSPWAERANQLKQSLGEVGQLRDIIQSKDAELLENLKTIKAKEAELIEEKRKEESFDKRIRILQKSENEVTEKLAKEIKSREDNEKNFRQALNLLRNEKNSLEHDSKNMQNKILALQQELQKKLNTPLSPMIANQELLRSVDDINVLSLKKAIRFLRNENLKLKSQKSIKELCELNLIQNYRHQQQIKQQQQQQSNNSSTSSTSSSTPTLLEQQAKKQQIKFNEIVEYSKQVNHMMSSILESTATPKVLDLSNKSISSSSSSSSSSNDRTSANEIEKQKLLIKQQERKVKQLQSKMTNFISSSTCQFGLNNYADANQSRMLKESIPLKIANITIPNLNINNINNNNNNTNSLMLDKDIQEALNSKTLSIQLFTNPQTFKEIHQVFVK
Protein: LP02106p (Q95R99)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHTIQQITAGAAGGAGAVQLTPGLVPLVTSTLISHNAAAQQQSQKQQAAAAAAAQQQAAAAAAAQQQAAQQQAAAAHQQHQQQVAAQHQQQAAVAAHQQQQQQLQQQQQLLQLSIQQAAHHHQQEQHRQQQQQQHQQQQQQQHHQQQQQGHPQAPPPQQQQQPPPIALISDPSALARAAIQLQHLPANVEQHPVVY
Protein: Putative delta 6-desaturase (Q98SW7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGGGGQQTESSEPAKGDGVGPDGGRGGSAVYTWEEVQKHCHRSDKWLVIDRKVYNITQWAKRHPGGIRVISHFAGEDATDAFVAFHPDPNFVRKFLKPLLIGELATTEPSQDHGKNAVLVQDFQALRDRVEREGLLRARPLFFSLYLGHILLLEALALGLLWVWGTSWSLTLLCSLMLATSQSQAGWLQHDYGHLSVCKTSSWNHVLHKFVIGHLKGASANWWNHRHFQHHAKPNVFSKDPDVNSLHVFVLGDKQPVEYGIKKLKYMPYHHQHQYFFLIGPPLVIPVFFTIQIFQTMFSQRNWVDLAWAMTFYLRFFCCYYPFFGFFGSVALISFVRFLESHWFVWVTQMNHLPMEIDHERHQDWLTMQLSATCNIEQSTFNDWFSGHLNFQIEHHLFPTMPRHNYHLVAPLVRALCEKHGLPYQVKTLQKAIIDVVGSLKKSGDLWLDAYLHK
Protein: Nucleoredoxin (EC 1.8.1.8) (Q6DKJ4)
Organism: Homo sapiens (Human)
Function: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P97346}. Nucleus {ECO:0000250|UniProtKB:P97346}.
Interaction partners:
- Segment polarity protein dishevelled homolog DVL-1
- Neuroligin-1
- Band 4.1-like protein 5
- Thioredoxin
- Neurexin-1
- Contactin-associated protein 1
- Leucine-rich repeat transmembrane neuronal protein 2
- Neurexin-2
- Segment polarity protein dishevelled homolog DVL-2
- Protein crumbs homolog 3
Sequence:
MSGFLEELLGEKLVTGGGEEVDVHSLGARGISLLGLYFGCSLSAPCAQLSASLAAFYGRLRGDAAAGPGPGAGAGAAAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRKLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVNDFLAEKLKPEPI
Protein: Tubulin-folding cofactor D (AtTFCD) (Protein CHAMPIGNON) (Protein EMBRYO DEFECTIVE 133) (Protein TITAN 1) (Q8L5R3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates microtubule function in seed development. Required for development of both embryo and endosperm tissue. Not essential for cell viability. Probably involved in the binding of beta-tubulin in the multimeric supercomplex.
Interaction partners:
- ADP-ribosylation factor-like protein 2
- Tubulin-folding cofactor B
- Tubulin-folding cofactor E
- Prefoldin subunit 4
- Gamma-tubulin complex component
- Mitotic spindle checkpoint protein MAD2
- Gamma-tubulin complex component
- Mitotic spindle checkpoint protein MAD1
- Protein NEDD1
- Transducin family protein / WD-40 repeat family protein
Sequence:
MASRAEEMSPTKIEIETAVKIEEEEDDEHDSKERVLQRYFLQEWKLVKSLLDDIVSNGRVVDPTSVHKIRSIMDKYQEQGQLVEPYLESIVSPLMFIIRSKTVDLEAKPDEILEIIKPISIIIYALVTVCGYKAVIKFFPHQVSDLELAVLLLEKCHSTNSVSALRQESTGEMEAKCVTLLWLSILVLVPFDISSVDTSIADDKTFGVDDLAPLVLKILGFCKDYLCSAGPMRRISGLLLSKLLTRPDMGKAFSSFFEWTYEVLSCKEDSVTNHFRLLGVMEALSAIFKTASRKVLLDVLPIVLNDVTVLSKSNAAAKSSLLRKYLIKLTQRIGLVCLPHRSPSWRYVAQTASLSENMSTSSSQRLAPDHTVTAILQPESLDDQEDEDMDVPEILEEIIEMLLSGLRDTDTVVRWSAAKGIGRVTSRLTSVLSDEVLSSVLELFSPGEGDGSWHGGCLALAELARRGLLLPRSFPLVVPVIVKALHYDVRRGPHSVGSHVRDAAAYVCWAFGRAYSHKDMKNVLDQLAPDLLIVGSFDREVNCRRAAAAAFQENVGRQGNYPHGIDIVSIADYFSLSSRVNSYLQVAVSIAQYEGYLYPFVDELLYNKICHWDKSLRELAAEALAPLVKYEPKHFANYVLEKLIPCTLSTDLCMRHGATLAAGEVVLALHQCGYVLSADSQKRMAGIVPSIEKARLYRGKGGEIMRLAVSRFIECISLSHVTLAERTERILLDTLTENLRHPNSQIQNAAVSAVKQLVQSYLVGNDKKSVDLILKHLKHLTDPNVAVRRGSALALGVLPYELLTAKWKDIVLKLCSACKIEVNPEDRDAEARVNAVKGLTSVCETLTQKRASDPGNDDLSLFLLIKTEVMDTLLKALDDYSVDNRGDVGSWVREAAVHGLEKCTYILCKKMETYSEGDYNDDTSSLFDSNLATRLIGGMLKQGVEKMDKLRETAAKVLQRILYHKSVSVPHVPYREKLEEILPNKANLQWAVPAFSFPRFVQLLKLRCYSKEVMSGLVISIGGLQDSLRKASLVALLEYMREGEAKDPKEQQSRESALGDDILWILQEYKKCDRVMVPCLQTIEILFSSKIFLNQESYTFSFYAGVMDSLAIELRASKDFTKLKAGLAILGYIASVSHFISTKAFSQLLSFLGHRYPMIRKAAAEQVYLALLQNGILVTEEKMEKVIEIISESCWEADMETTKTQRLELCELAGLDHEVVFKTRNRLVIKDIAGNKSAADENASYSSLVDSSGF
Protein: Maleate isomerase (EC 5.2.1.1) (Maleate cis-trans isomerase) (O24766)
Organism: Alcaligenes faecalis
Function: Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.
Interaction partners:
- Succinate dehydrogenase flavoprotein subunit
- N-carbamoylsarcosine amidase
- N-carbamoylsarcosine amidase
- 2,5-dihydroxypyridine 5,6-dioxygenase
- 2,5-dihydroxypyridine 5,6-dioxygenase
- 2,5-dihydroxypyridine 5,6-dioxygenase
- Aspartate ammonia-lyase
- Arylmalonate decarboxylase
- Alpha/beta hydrolase
- Alpha/beta hydrolase
Sequence:
MKTYRIGQIVPSSNTTMETEIPAMLQARYAEFPEERFTFHSSRMRMMHVNPEELKAMDIASDRCAVELSDARMSVMAYACLVAIMAQGDGYHRVSQARLQNTVKENGVEIPVLSSAGALVDTLKEFGYKKVSIITPYMKPLTKRVADYIEAEGIEVQDSISLEVSDNLEVGLLNPENLLEHVKRLNHDGVDAVILSACVQMPSLPAIQRAQDQIGKPVLSAAVWTVYQMLKNLGLETRVPNAGHILSGVKPQA
Protein: Putative RNA-binding protein Luc7-like 1 (Q9CYI4)
Organism: Mus musculus (Mouse)
Function: May bind to RNA via its Arg/Ser-rich domain.
Interaction partners:
- U1 small nuclear ribonucleoprotein C
- Pre-mRNA-processing factor 39
- Small nuclear ribonucleoprotein E
- RNA-binding protein 25
- U1 small nuclear ribonucleoprotein 70 kDa
- Small nuclear ribonucleoprotein-associated protein N
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLGRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKFSRSRSRDRYRRHRSRSRSHSRGHRRASRDRSTKYKFSRERSLREESWEYGRNERGPTDWRLENSNGKTASRRSEEKEAGEI
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (Q9V433)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- DEAD-box ATP-dependent DNA helicase Fancm
- Crossover junction endonuclease MUS81
- DNA topoisomerase 3-alpha
- DNA topoisomerase 3-beta
- Serine/threonine-protein kinase ATR
- DNA repair protein Rad51 homolog
- DNA replication ATP-dependent helicase/nuclease
- Flap endonuclease 1
- DNA topoisomerase 1
- Double-strand break repair protein
Sequence:
MAHESAVHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDLLQTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQPVAQFSTPSFRKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYCRTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTERAIKQFEKITEFCERTTCRHKLFSDFFGDPTPDCSGQCDVCKRPKKAEKALEIFHRLCMDDAFKSHISLQDCADLYEGGRPGIKRAAQEYAGGESGSDDDSGQSHSSMAKRAKKESQDFIKQQFNLRKQISAARQLEQETIAQISRVRMAEATEKKIAGLQATHREKYLTALIDALKANVDKCKDEPGQQPKSVLKYNDYEAMSVNMEYDVFRQNKVANMYRHALVKEISTIKKLTEQTKLLPLLVDYIPKPETSSKGAWTGGSVAYFERKLKELEEQRPQSLKEVPKALKDRKGFKQENSKQTSISSFFKKEIKEEPIDSPIQEERVNIKSEQMDLEESTPKDIASNHVKEESVTPESSSSDRELELQPDSIIGERKFKLMSNGDGSYDTHRRKRVSHETQPKEKESIKTKSSMQHLFGSFKSESEESNQSLNGFKTARQMLEENNSKLEGVPEKLPIKDGEKRVLENRADSIGFTSAREMLERSKQREGDDKSSNKLEKLGFISAREMLEKNKLNERCLDKKDVKEKKLESRETKRSLQNNELQHKQEEDRKDKASHRKTSKESLSNLKKEGSDSRVLQKDTKPETRNHQKTDVSKNVVQWLNPYYKRKIATKELFKALAKLLTQRICDGSLGDGDAGKCYIKETFHGLQMINNDQDIEKYFIKSK
Protein: DND microRNA-mediated repression inhibitor 1 (Dead end protein homolog 1) (F1RGE0)
Organism: Sus scrofa (Pig)
Interaction partners:
- Nanos C2HC-type zinc finger 3
- Deleted in azoospermia-like protein.
Sequence:
MQSKRECELWCERVNPENKAALEAWVRETGIRLVQVNGQRKYGGPPPGWVGSPPPAGSEVFIGRLPQDVYEHQLIPLFQRVGRLYEFRLMMTFSGLNRGFAYARYSSRRGAQAAIATLHNHPLRPSCPLLVCRSTEKCELSVDGLPPGLSRRALLLALQPLGPGLQEALLLPSPGPAPAQIALLKFSSHRAAAMAKKALVEGQSHLCGEQVAVEWLKPDLKQRLRQQLMGPSLRCLQSEGSQLALARDKLESQGARAALQLLCQRMKLGTPVFLTKCLGTGPATWHHFWYQVVIPGHPVPFSGLIWVVLASDGQDGHEVAKEAVSARLLETLSESGASLLRSAVAEAGTMVQQ
Protein: POU domain, class 6, transcription factor 1 (Brain-specific homeobox/POU domain protein 5) (Brain-5) (Brn-5) (P56223)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MPGISSPILTNAQGQVIGALPWVVNSASVATPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPSTPESPAKSEVQPIQPTQAVPPPAVILTSPAPALKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP
Protein: Vasculin (GC-rich promoter-binding protein 1) (mGPBP) (Q6NXH3)
Organism: Mus musculus (Mouse)
Function: Functions as a GC-rich promoter-specific transactivating transcription factor.
Subcellular location: Nucleus {ECO:0000269|PubMed:14612417}.
Interaction partners:
Sequence:
MAQHDFAPAWLNFPTPPSSTKSSLNFEKHSENFSWTENRYDVSRRRHNSSDGFDSGIGRPNGGNFGRKEKNGWRTHGRNGTENINHRGGYHGGNSRSRSSIFHSGKSQGLHENSIPDNETGRKEDKRERRQFEAEDFPSLNPEYEREPNQNKSLAAGVWDYPPNPKSRTPRMLVIKKGNTKDLQLSGFPVAGNLQSQPVKNGTGPSVYKGLVPKPAVPPTKPTQWKSQTKENKVGTSFSHESTYGVGNFNTFKSTAKNISPSTNSVKECNRSNSSSPVDKLNQQPRLTKLTRMRSDKKSEFLKALKRDRVEEEHEDESHAGSEKDDDSFNLHNSNTTHQERDINRNFDENEIPQENGNASMISQQIIRSSTFPQTDVLSSSLEAEHRLLKEMGWQEDSENDETCAPLTEDEMREFQVISEQLQKNGLRKNGILKNGLICDFKFGPWKNSTFKPTIENDDTETSSSDTSDDDDV
Protein: Olfactory receptor 5D14 (Olfactory receptor OR11-141) (Olfactory receptor OR11-150) (Q8NGL3)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MMMVLRNLSMEPTFALLGFTDYPKLQIPLFLVFLLMYVITVVGNLGMIIIIKINPKFHTPMYFFLSHLSFVDFCYSSIVTPKLLENLVMADKSIFYFSCMMQYFLSCTAVVTESFLLAVMAYDRFVAICNPLLYTVAMSQRLCALLVAGSYLWGMFGPLVLLCYALRLNFSGPNVINHFFCEYTALISVSGSDILIPHLLLFSFATFNEMCTLLIILTSYVFIFVTVLKIRSVSGRHKAFSTWASHLTSITIFHGTILFLYCVPNSKNSRQTVKVASVFYTVVNPMLNPLIYSLRNKDVKDAFWKLIHTQVPFH