wanglab/gogpt-training-data huggingface dataset:
Protein: AN1-type zinc finger protein TMC1 (Trivalent metalloid-sensitive Cuz1-related protein 1) (Q08422)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May have a role in protecting cells from metalloid-induced proteotoxicity.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL38
- Ubiquitin-ribosomal protein eS31 fusion protein
- Large ribosomal subunit protein eL30
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein eS21B
- Small ribosomal subunit protein RACK1
Sequence:
MSDINEIEIPSRKDEIRQVTPKDPMHEIEDKSTYHAKIKKSDSGTVLGAIPLNSRSSSNSSVTSTGQSSRRVTKKTTKKKKKNACYFDTCSSAASKFIGDCNFCKGHFCSKHRLMENHACNGLTSCKEQLHQRNADKLEAEQTKAPKIQI
Protein: Histidine-containing phosphotransfer protein 2 (OsAHP2) (OsHP1) (OsHpt3) (Q6VAK4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay (By similarity). Functions as positive regulator of the cytokinin signaling pathway. May play a regulatory role in salt and drought tolerance during plant development.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22383541, ECO:0000269|PubMed:24578505}. Nucleus {ECO:0000269|PubMed:22383541, ECO:0000269|PubMed:24578505}.
Interaction partners:
- Probable histidine kinase 4
- Probable histidine kinase 5
- Probable histidine kinase 3
- Probable kinase CHARK
- Two-component response regulator ORR22
- Two-component response regulator ORR21
- Probable histidine kinase 6
- Os07g0576700 protein
- Two-component response regulator ORR26
- Two-component response regulator ORR24
Sequence:
MAAAALRDQLTALLSSMFSQGLVDEQFQQLQMLQDEGGTPGFVSEVVTLFCDDADRIINEIATLLEQPVVNFDKVDAYVHQLKGSSASVGAQKVKFTCMQFRQFCQDKSRDGCLMALAVVRNDFYDLRNKFQTMLQLEQQIQAYDPKQQ
Protein: Down syndrome cell adhesion molecule 1, isoform AA (Q0E9J3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVNQYYEAEVVSEYVIRGNTAVLKCTIPSFVADFLRVEAWVASDGTEYAPEEDFDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVGPKVEIKDKVGIFVAKSNSSLALLCPAQSYPIPAFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFDFGEETVNELDMVSASCTVNKGDLPIDVAWTKNGGRVYTNDGIVVTKTSTRMSVLSIESARARHAGNYSCVATNNAGETRQWAVLAVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPSRDLPELSAEDTIRIILSNLNLVVPVVAALLVIIIAIIVICILRSKGNHHKDDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQQANGAGFTAYDTMAV
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) (P25007)
Organism: Drosophila melanogaster (Fruit fly)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Cytoplasm.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase Fkbp12
- Nucleoside diphosphate kinase
- Large ribosomal subunit protein uL4
- Elongation factor 1-alpha 1
Sequence:
MVSFCATLIRQFRHRSAAAFQIAESAILANKSITLASSACSVNRGQLQFGIQIVREYSKASKMSTLPRVFFDMTADNEPLGRIVMELRSDVVPKTAENFRALCTGEKGFGYKGSIFHRVIPNFMCQGGDFTNHNGTGGKSIYGNKFPDENFELKHTGSGILSMANAGANTNGSQFFICTVKTAWLDNKHVVFGEVVEGLDVVKKIESYGSQSGKTSKKIIVANSGSL
Protein: RNA binding motif protein 7 (J3KPD3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLYGRPIKIQFRSGSSHAPQDVSLSYPQHHVGNSSPTSTSPSSRYERTMDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH
Protein: Uncharacterized protein (Q381T6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGGGTRDEATDARYYGLRVYPLVDVLSRVPLPPLCPLAGVSKKWRCVIVPKINEVSEHVSGGICSVDRTGESEALKFLDSGVPCRLGRWRSEAVYGITGSDGMKFVTDSRWNEFPKPKIAFKAGWAGPGTHMESPAYYQLISSFKDVFERAPKGEKTSEAPDIPVDGEAATAETRDEEEDTVVPNILNLQLFHREDPSKCPAIPVLGESLVWPSFLEDGAICDNATRLSQRGAVTWWHLDDSGEFVQQTALPLKTSNGTFLPPPLTTLPENQRKYFTDIDRELYCVDDTAESIPVKLFLYGPKESYDWFMHDGESATSGKVAALDIFNTPDEALPGDPTLLPIIHVALLESGSRPLISPPNIPHIVVTLNDCIMVEQRRLAYLFMEEISYFLQKCAHWSDNPIIYDHVETDLQDESFVAGQLIPLLMSVFSGHSGLNPYEETIRRRVVMALFTLATHEKHYKLSTDSRSSLHTLLHGGNAEMSAILRQAVSYGRRVVSLEDRLKAYWEVEQYWPKPGCVMRVPLLTPPQLLSSEILAKQVTVDWFVPVVYAASSPVFGAEKNSVEEVSEQYFTMAKLSGKRQELLAYLRTRVERDSILDELF
Protein: P-type phospholipid transporter (EC 7.6.2.1) (A0A8I6GMN6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
GVLKGFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNNQNSHSLFLLFRYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACESKDGIDNVDMSSKDSGSSLIRRRSTRKSIRGPHDQDGELSTKENTRKSCAYGRALHSKINDKQNKRNQFCCHVYLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKNDTPEIQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQAGAKRS
Protein: Uncharacterized amino-acid permease C15C4.04c (O60113)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Barrier septum. Cell tip. {ECO:0000255, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized amino-acid permease C965.11c
Sequence:
MDSVSNVSVNEQGKFNDKEEGFSNLKSLKHVSHSETDFEVSNDEDNQLLELGYKPVFKREFSTWATFSFAFSISGLFATVVTTYSYPLISGGAPSAVWCWLIAGAGCMCIALSVAELVSAYPTSGGLYFTCKDLVPARSMPVVAWVVGWLNLLGQAAGVSSTDWSCAQLLLAAVSISTDLKYIPTNQHIVGVMAAVIVFHGLVNSLSTRWLDRITRFYATFHLIVLVVCMICLLAKCPKFNTGKYVFTDVQASSGWHPIGFSFLFGFLSVAWCMTDYDATAHIAEEIENAAVRAPNAIALALSITYVLGWVFNIVLAFTMGTDLDSLINSELGQPVAQIFYNVLGKKGSMAFTILSFIIINFTGITAMQANARTIWAFSRDQALPFSRYWYKINKTTTTPVIAVWLNVVFCIALNLIGLGSIEAIEAIFSVCAIALDWSYVIPIACKLIFGKRLNYKPGPWNLGWASHFVNAYAVCWTAFVSVIFLMPTVRPVTPQNMNYAVVVLAGVLLFSLVYWWSGARKSYIGPRINVDMESEDPFKTE
Protein: PITH domain-containing protein P35G2.02 (Q9P7A1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein uL3m
- Tethering factor for nuclear proteasome cut8
Sequence:
MSGPHHCSADCDEHPFESGPNDTLYSCIRKESIVTLNEAVPDSGKLVFKPWDLRYDDTDIVESDADDQLLFQVPFAGAATLKSILVRIFPNETAPHSFSLFPNRTDLDFDTIGDVQATETFEFPLTFEGSHIFEFPVKTRLYQNLQNLNIFFTKSDGSDDPTQIAYIGLRGSFVPFKGDPVVTIYEATPRPSDHPKVNQEEVFRSYY
Protein: Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2) (Q61039)
Organism: Mus musculus (Mouse)
Function: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor GATA-4
- Homeobox protein Nkx-2.5
- T-box transcription factor TBX5
- Runt-related transcription factor 2
- Interleukin-4
- Interleukin-13
- Interferon gamma
- T-cell surface glycoprotein CD4
- Interleukin-5
- Trans-acting T-cell-specific transcription factor GATA-3
Sequence:
MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ
Protein: Rab GTPase-activating protein tbc-8 (TBC domain family member 8) (I2HAA0)
Organism: Caenorhabditis elegans
Function: Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. GTPase activator for rab-2. In association with ric-19 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:22654674}. Early endosome {ECO:0000269|PubMed:22654674}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:22654674}; Peripheral membrane protein {ECO:0000269|PubMed:22654674}. Note=Co-localizes with ric-19 at cytoplasmic vesicle membranes in neurons. {ECO:0000269|PubMed:22654674}.
Interaction partners:
- Resistance to inhibitors of cholinesterase protein 19
- RUN domain-containing protein
- CARD domain-containing protein
- Rab-GAP TBC domain-containing protein
- TBC1 domain family member 23
- Ras-related protein Rab-7a
- Rab GTPase-activating protein tbc-11
Sequence:
MQMFRHSSADMWRAKKPTLERRSTDGRRSSIVDWINGLSDNNNYKSDHWVEKHDEGCERMTRNGSVCAVEESEPDVPTQHREVLLTKLKIEIKNIMAEHGAKKYLNLNSPYVTSLCIAVDACIMDGLRRRLLTLFNSPSSMSLLQIIAKSNGPAQQVLDQTREIEELRTSAIPVHLIWIREALYLKSLSTIINHFIDSKSVRRYYDNSALLLDPVKGRLVATLMMAPCMVTYRRMSNRIEQEATAEELVEGATRGSTSTVPSRPPLSITRQVSSIAASVERNGSVSRDYVFSLHHSCKSTLLYGKNNVCVAMNGSDFAKGYMSLQKFYDGNLSLKWVPNQLMHASSQPSSGHSNNGEFTNIWKNTINIEMQDIIYIHLHQKDEISPTCLTFVNCEGVQSAPFQLPAGQHSIAFLSSLETGLAPLLRLDPPLWVGTTKEKILPRLRKRSTAVANPAMLDYVFRLVRTSGVEPAPEDIEDPLAPTSHSPPIHDNCVSLPNSPYIVDNVDSIVNFQIGTACQSMRNQIMARAFYGWLTYVRHLRTIRTHLLHLVDTKTLICDDDCDPVDEKFWKQARAEPTEENEKEFLKRVYWRGIEGINTKEVRRMAWPYLLGLFEWNESPESRLEQFTSQYWQDIEEWRVLEAEVRRRDEEAFRAARARKAASPVREESCDVFEDPNEPTCSQHYDRENLITLFRANLHRIDKDVERCDRNLMFFSNKDNLESLRRVMYTYVRRNLEEGYTQGMCDLLAPLLVTFEDEALTLECFSLLMLRQRGKFPQRPGMSKCLLNLRSLIQVVDPQIYALISDIDYAQALSFAFRWFLLDFKRELSYECTYKVWEVIWAAQRLRITDDFAIFFGLATITNYHDVLITNNFDYTDMIKFFNEMAERHDCSRLLSSARTHVKCLQNLVQHLK
Protein: F28N24.3 protein (Intracellular protein transporter, putative (DUF641)) (Q9LP57)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Emb|CAB72159.1
- Alba DNA/RNA-binding protein
- Transcription factor SRM1
- Transcription factor GTE7
Sequence:
METLKKNPSVRRKSKLARTFQKVCNLRTTSTKVSSNNGIGICMLKSQNPNFDDEDDDGDSVFDLKSTSSSRSGEIKVRERNRAVLQAVVAKIFASTTSIKAAYAELQMAQRPYDNDAIQAADTAVVEELRALSELKRSFLRKELNLSPQVAIMLAEIQEQQSLMRTYEITIKKLEFEVTEKQLKIDELKMSFEESLVVNKSLEKKLSASGSVSVFDNIEIRNLNLSSFVQVLGFTLRSVRSFVKLIVKEMESASWDLDAAASAAVSVNVKNASTVFARPSHRCFAFESFVCGKMFENFGAPDFSRREEFEKLRSVDPIQYLTRNPGSSFARFVVHKYLSVVHAKMECSFFGNLNQRKLVNSGGFPDSGFFATFCEMAKRIWLLHCLAFSLSGNVTVFQLKRGCRFSQVYMESVKSGDESLFSGDNSDIRVGFTVVPGFKIGENVIQSQVYLTPVNGFTS
Protein: UvrABC system protein C (Protein UvrC) (Excinuclease ABC subunit C) (P56428)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
Interaction partners:
- UvrABC system protein B
- UvrABC system protein A
- Uncharacterized protein
- Homoserine dehydrogenase
- UPF0102 protein HP_0823
- DNA polymerase III subunit alpha
Sequence:
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQDALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKKNCIKDKKACIFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKIAPFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLNACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDTSHHSSSQCVGGMVVYENNAFQKNSYRRYHLKGSDEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGSFVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGIGEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI
Protein: Probable ubiquitin carboxyl-terminal hydrolase 9 (EC 3.4.19.12) (Deubiquitinating enzyme 9) (Ubiquitin thioesterase 9) (Ubiquitin-specific-processing protease 9) (Q9P7V9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Ubiquitin C-terminal hydrolase involved in regulating actin dynamics and/or endocytosis at cell tips and septa.
Subcellular location: Nucleus {ECO:0000269|PubMed:20838651}. Cytoplasm {ECO:0000269|PubMed:20838651}. Cell tip {ECO:0000269|PubMed:20838651}.
Interaction partners:
- UBP9-binding protein bun107
- UBP9-binding protein bun62
- Ubiquitin carboxyl-terminal hydrolase 14
- Ubiquitin thioesterase otu2
- AMSH-like protease sst2
- Probable ubiquitin carboxyl-terminal hydrolase 1
- Ubiquitin carboxyl-terminal hydrolase mug105
- Putative ubiquitin thioesterase otu1
- Ubiquitin carboxyl-terminal hydrolase 11
- Probable ubiquitin carboxyl-terminal hydrolase 7
Sequence:
MSLLRWMGMNSPGSTDRRKSTWEAELPKPSIRPETLTDRFYGLTNYGNTCYVSSVLVSLYHLKPFRDSLNSYPLPSAPPNFKSVCTKTNHPESSSSRHSKKKSMENRKSSLYGSNGINSCGCVDISNVGSESGTKHQIVVGESNCSAYGMKENIYTCLKDLYCSVSCCDCRYGICSPERFIQVLRRDNEAFRSTQQQDAHEFFNFLLNSVTETLDEYYGNHSDVMHPKWVHSLFEGTLTSETKCLTCENITSRDESFLDLSIDIENHTSVTSCLRSFSASEMLSSKNKFHCDVCKSLQEAEKRMKIKKLPKILSLHLKRFKYNETQEGHDKLFYTIVFTNEMRLFTTTEDAENAERMYYLSSVIVHVGGGPHRGHYVSIVRTKTYGWVLFDDENVTPVNENYLQRFFGDQPGQATAYVLFYTAADEEDDDVSEVDTKESIKPMSIPSQLKQESVEVSNLSSTPRSNSTITYPDMDPMVASFSSQYSHKTLDRDINSRSYFDREPSLDAERFHSRSVDASPKAVRRESRSFFPSLTRKRSKFFGSSQSNSPKDSPLRDTHKSSDEHSESKHSHTLPWQFSRSRSKR
Protein: Ras-related protein Rab-31 (EC 3.6.5.2) (Q921E2)
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes.
Subcellular location: Early endosome {ECO:0000250|UniProtKB:Q13636}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q13636}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q13636}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250|UniProtKB:Q13636}.
Interaction partners:
- Ras-related protein Rab-22A
- Rab5 GDP/GTP exchange factor
- GTPase-activating protein and VPS9 domain-containing protein 1
- Geranylgeranyl transferase type-2 subunit alpha
- Ras and Rab interactor 3
- DCC-interacting protein 13-alpha
- Rab GDP dissociation inhibitor alpha
- Rab GDP dissociation inhibitor beta
Sequence:
MMAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFHTLKKWVKELKEHGPENIVMAIAGNKCDLSDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLGPQENGNSGGIKLGNQSLQASRRCC
Protein: Proteasome subunit beta (Q7K148)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU004203}. Nucleus {ECO:0000256|RuleBase:RU004203}.
Interaction partners:
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-2
- Proteasome subunit beta
- Proteasome subunit alpha type-5
- Proteasome subunit beta type-1
- Proteasome subunit beta type-3
- Proteasome subunit beta
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-7-1
Sequence:
MALAEICKISNAPYMRPNAWSSADVEEEQKGLMCNLANPYTLAAPPFENPLHNLNQIQANGDKTGVKINFDHGTTTLGFKFKGGVLLAVDSRATGGSYIGSQSMKKIVEINQFMLGTLAGGAADCVYWDRVLSKECRLHELRNKERISVAAASKIMANIAHEYKGMGLSMGMMLAGYDKRGPGLYYVDSEGSRTPGNLFSVGSGSLYAYGVLDSGYHWDLEDKEAQELGRRAIYHATFRDAYSGGIIRVYHIKEDGWVNISNTDCMELHYMYQEQLKQQAAK
Protein: Palmitoyltransferase ERF2 (EC 2.3.1.225) (DHHC cysteine-rich domain-containing protein ERF2) (Ras protein acyltransferase) (Q06551)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10490616, ECO:0000269|PubMed:12379641}; Multi-pass membrane protein {ECO:0000269|PubMed:10490616, ECO:0000269|PubMed:12379641}.
Interaction partners:
- Ras modification protein ERF4
- GTP-binding protein RHO2
- Serine palmitoyltransferase 1
- Serine palmitoyltransferase 2
- Protein ORM1
- Serine palmitoyltransferase-regulating protein TSC3
- Phosphatidylinositol-3-phosphatase SAC1
- Protein ORM2
- Ras-like protein 2
Sequence:
MALVSRRSTRSESTSITKEEHTGEGSLTKLFFRWLVTLEGDQDINDGKGYISLPNVSNYIFFLGGRFRTVKGAKPLWLGVLLAIVCPMVLFSIFEAHKLWHTQNGYKVLVIFFYYFWVITLASFIRTATSDPGVLPRNIHLSQLRNNYQIPQEYYNLITLPTHSSISKDITIKYCPSCRIWRPPRSSHCSTCNVCVMVHDHHCIWVNNCIGKRNYRFFLIFLLGAILSSVILLTNCAIHIARESGGPRDCPVAILLLCYAGLTLWYPAILFTYHIFMAGNQQTTREFLKGIGSKKNPVFHRVVKEENIYNKGSFLKNMGHLMLEPRGPSFVSARKPHEAGDWRFMDLSPAHSFEKIQKI
Protein: Nucleoporin NUP42 (Nuclear pore protein NUP42) (P49686)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP42 is specifically important for nuclear protein and mRNA export.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.
Interaction partners:
- Nucleoporin NUP57
- Nucleoporin NUP100/NSP100
- Nucleoporin NUP116/NSP116
- mRNA export factor GLE1
- mRNA export factor GLE2
- ATP-dependent RNA helicase DBP5
- Nucleoporin NUP159
- Nucleoporin NUP2
- Nucleoporin NSP1
- Nucleoporin ASM4
Sequence:
MSAFGNPFTSGAKPNLSNTSGINPFTNNAASTNNMGGSAFGRPSFGTANTMTGGTTTSAFGMPQFGTNTGNTGNTSISAFGNTSNAAKPSAFGAPAFGSSAPINVNPPSTTSAFGAPSFGSTGFGAMAATSNPFGKSPGSMGSAFGQPAFGANKTAIPSSSVSNSNNSAFGAASNTPLTTTSPFGSLQQNASQNASSTSSAFGKPTFGAATNTQSPFGTIQNTSTSSGTGVSPFGTFGTNSNNKSPFSNLQSGAGAGSSPFGTTTSKANNNNNVGSSAFGTTNNQSPFSGGSGGTFGSASNLNKNTNGNFQSSFGNKGFSFGITPQNDANKVSQSNPSFGQTMPNTDPNISLKSNGNATSFGFGQQQMNATNVNANTATGKIRFVQGLSSEKDGILELADLAEETLKIFRANKFELGLVPDIPPPPALVA
Protein: Retinol-binding protein 2 (Cellular retinol-binding protein II) (CRBP-II) (Q08652)
Organism: Mus musculus (Mouse)
Function: Intracellular transport of retinol.
Subcellular location: Cytoplasm.
Interaction partners:
- Lecithin retinol acyltransferase
- Retinol dehydrogenase 11
Sequence:
MTKDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKIITQDGDNFKTKTNSTFRNYDLDFTVGVEFDEHTKGLDGRHVKTLVTWEGNTLVCVQKGEKENRGWKQWVEGDKLYLELTCGDQVCRQVFKKK
Protein: Dephospho-CoA kinase (E5QCF6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLVVGLSGGVATGKSTVSSVFRAHGVPIIDADQVARQVVVPGTSTYNRLRKEFGDEYFDDEHGGVLRRDKLGKLIFSNPEKRKALNGITHPAIRWEMFKQFLTLLITGTKYIVFDTPLLFESGYDKWIGTTIVVWCDFEQEVERMVTRDNISRADAESRIHAQMDIEEKKKRAKIVIDNNGNIDELREKVKHVIAQLDKSWKPYIFRVAFGIILGVVPYYFFKYIRS
Protein: Putative defense protein 1 (DFP-1) (Q0Q029)
Organism: Antheraea mylitta (Tasar silkworm)
Function: As this protein is expressed upon bacterial infection, it may have antimicrobial activity.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MMFAYIVAVVSALALTSAFPTGAPRSACFDMIPGHFANPKLEPAPYTITTPISAVKGGNSVEVTISGKTPEDTMRGILLEARQGDNIVGTWTVPPGDDFSQPMNCGEPNNAVTHKRHSESADKQTVSYVWTAPSDLEGDVVFMVTIVKDYSNFWVRQTSAPVKILSHH
Protein: dATP triphosphohydrolase (dATPase) (A0A2H5BHG9)
Organism: Acinetobacter phage SH-Ab 15497
Function: Catalyzes the hydrolysis of dATP, dADP and dAMP into dA. This step is essential for Z-genome synthesis (containing aminoadenine instead of adenine). Specifically removes dATP and its precursor dADP from the nucleotide pool of the host, preventing the incorporation of A into the phage genome and favoring the integration of the Z-base into the viral genome.
Interaction partners:
Sequence:
MDKLNIRDILRAQDVTRWQIVRTKKQSVAEHTFAVQAVLMRLVPLLISTYTAPMKVGFEERLLCECIMGAFWHDIPEVITGDIASPVKRLIRDGGDITPLDDLEKKVDPAFIKCYTAAKPLTLAIIKCADLMEMVYHLNEYGDQRANSHSWRVQHGINNAFHEHIHNCSENFPAFKWDVAHGLLIEMLDPSQETDIDSIVNGI