wanglab/gogpt-training-data huggingface dataset:
Protein: Histone acetyltransferase Tip60 homolog (EC 2.3.1.48) (Myst family histone acetyltransferase-like protein 1) (Q9TYU5)
Organism: Caenorhabditis elegans
Function: Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92993}.
Interaction partners:
- Transcription-associated protein 1
- histone acetyltransferase
- RuvB-like 1
- Cell division cycle 5-like protein
- Enhancer of polycomb-like protein
- Histone H2A.V
- Mortality factor related protein 1
- Helicase ssl-1
- Chromatin modification-related protein MEAF6
- DNA methyltransferase 1-associated protein 1
Sequence:
MTEPKKEIIEDENHGISKKIPTDPRQYEKVTEGCRLLVMMASQEEERWAEVISRCRAANGSIKFYVHYIDCNRRLDEWVQSDRLNLASCELPKKGGKKGAHLREENRDSNENEGKKSGRKRKIPLLPMDDLKAESVDPLQAISTMTSGSTPSLRGSMSMVGHSEDAMTRIRNVECIELGRSRIQPWYFAPYPQQLTSLDCIYICEFCLKYLKSKTCLKRHMEKCAMCHPPGNQIYSHDKLSFFEIDGRKNKSYAQNLCLLAKLFLDHKTLYYDTDPFLFYVLTEEDEKGHHIVGYFSKEKESAEEYNVACILVLPPFQKKGYGSLLIEFSYELSKIEQKTGSPEKPLSDLGLLSYRSYWSMAIMKELFAFKRRHPGEDITVQDISQSTSIKREDVVSTLQQLDLYKYYKGSYIIVISDEKRQVYEKRIEAAKKKTRINPAALQWRPKEYGKKRAQIMF
Protein: ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor) (Q9Z2U4)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and in CD8+ T cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN. Is a negative regulator of pro-inflammatory cytokines expression, including IL17A, IL1B, IL6, TNFA and CXCL1. Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses.
Subcellular location: Nucleus, PML body {ECO:0000250}. Note=Accumulation into PML nuclear bodies is mediated by PML. {ECO:0000250}.
Interaction partners:
Sequence:
MAIALQPSDLVFEFASNGMDDIHQLEDPSVFPAVIVEQVPYPELVHLCSGLDLDEVHNGIIRDRTLCMTQDQILEGSILLTDDDVSTSNNVSSTEVLFNVATPSDVLDEKQIFSSPEVLSDSNSVQAINLPNFLLSTPEPDDLKKTSDAGDQKEHSEEEKVSREENLRKMGKARKRNRKTKNNRSTSPVTDPSMPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVIDDEEESPETPEDSSQASTSSTPSTSTIRRASSRVGTRASPEDKDNPPWEKPKVQHTGLQPSASLELGLSVDEEVPTTSTMLASPLQSQARLTKTVSSSPAPSNIHLGVAPVGPGSTVTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPQVSTFKDTFTLQTSFPLNTNLQENQVATQGAPLILSGLPQLLAGANPQSNPAPSQVIGAGSAGPSSQPPGTVIAAFIRTSSGTSVPVVKEGPLRSSSYVQGVVTGAPVEGLLVPEETLRELLRDQGHLQPLPSQVLSRGSHNLSLVGNQTLSPPSHPTVGLTPVAELELSSGSGPLFVTEPSVTRSPTQAPFSPFNPTSLIKMEPQDI
Protein: Alhambra, isoform B (LD39491p) (Q9VI61)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMMMDTMDTSQSQPMDVAPAVAVAATSGAALVDFTAAMVSMAATAEAESAESNNNHIDMAEYKEHRKNKKKKREKREREGKEHRHHKHRDREHREHRRHRDRDRDKERDREGHHHHPTHHHPNNSQHSTSASSSPSSASTTPSATIEYVGGSASASPSYLGGGATGTGAAVGATTTYPHNLKIRFLLSGQRTELSPPTHQTSATAEVNAPLASSTSASIAVTASATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSNIKDISSSSNQQASTASSSSAPSLYVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGPPMGGSAGAFHGGTTSAGSSSVIQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTESGNLKISYEKQTTRVQQLQEQEAPPARRSRTLDLSTASASSSSPSAVPATTSPLVVLSNQLPLNSVAASSSTGGLKFTYESQTQMDVPMMPVSAIKDSPPSSPGSEIGSAMHSATTAPGSLTGASTAATAQPGNVRKRGRKAKDATIAAAAAAAAAAAALSNSQQDLKDVRILQNGASNTPGNPAGSTPTPPATPASSNAVSSASSIITHTAAHMLGNQINPNSSVAQKLSEQLHMEVQDHSIYTPDSMNSQYAGVPFPGKQRNSTAVPSNATPAQNPLQSMFSGGGMNGNMPIPQSLEQLLERQWEQGSQFLMEQAQHFDIASLLNCLHQLQSENLRLEEHVTSLIARRDHLLAVNARLQIPLSTIASNTKAEAHGK
Protein: RmlC-like jelly roll fold protein (Q8GYZ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- UTP:RNA uridylyltransferase 1
- At5g49280
- mRNA-decapping enzyme-like protein
- Mitochondrial import receptor subunit TOM5 homolog
- Protein RRP6-like 3
- Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM3
Sequence:
MSSKMVKSSEIVGKLNLRAHQEGGFFAETFRDSSVFLSTSQLPPTFKVDRAVSTSIYFLLPSGSVSRLHRIPMAETWHFYLGEPLTVVELYDDGKLKFTCLGPDLFEGDQKPQYTVPPNVWFGSFPTKDVHFSQDGALLKAEARDSENHFSLVGCTCAPAFQFEDFELAKRSDLLSRFPQHESLITMLSYPE
Protein: Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A) (Q64093)
Organism: Rattus norvegicus (Rat)
Function: Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q8VDB9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VDB9}. Note=Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi. {ECO:0000250|UniProtKB:Q8VDB9}.
Interaction partners:
- Angiotensin-converting enzyme 2
- Collectrin
- Leucine zipper transcription factor-like protein 1
- Proton-coupled amino acid transporter 2
Sequence:
MRLAIKRRASRGQRPGPDEKRARDMEKARPQWGNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYLIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVCPLNSNRTGYDEECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTALMPYCVLIIYLVRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNDCQKHAVIVSVINSSTSIFASIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTASNLEEVKDYLASTYPNKYSEVFPHIRNCSLESELNTAVQGTGLAFIVYAEAIKNMEVSQLWSVLYFFMLLMLGMGSMLGNTAAILTPLTDSKVISSYLPKEAISGLVCLINCAVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLRAMTGRPLNWYWKAMWAFVSPLLIIGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASSTMCIPLVALGTFIRNRLKRGGSSPVA
Protein: Amphiphysin (Q6P960)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAEIKTGIFAKNVQKRINRAQEKVLQKLGKADETKDEQFEQCVQNFKRQEFEGSRLQREMKAYIAAVKGMQQASMNLTESLHEVYEPDWHGKDDVMTIGKNCDALWEDFHQKLVDSTINTLETYLTQFPDLKVRVAKRSRKLIDYDSARHHLETLQTSTMRNEKRIAKAEEDLKKAQRVFDDLNVGLQDELPTLWDSRVGFYVSTFKNVSSLEARFHREISFLCHKLYEVMNKLAEQHSDKMFTIQGAPSDSGPLRLARTPSPPDDESPDSSPAASPNHTLRPTSPGPPRPKSPSQLKMGPPKPPPPKVTPTRELQQEQIIDLFDGGFPEISVTSPQPNERPGESLLDLDFDPFKPDTSTPIGQTQSPVSQTLPWDLWTGDAAQPAQPATDAGFTANWAADFGSSATTVTDESANTQPAADGQGWPPADGWPTDSTPQPQGETATDEDATVPTFMADFDKMPEAEAEAPEGDVAEGEGEASPASEPEGGEGPVTTPPTDTQPEEITASSPPAETPTSTVESPVSAEPEAAEQAELPVEDIEKEQLSEESPDSVPVQETEKESPTEAALASVEDKESPIEETPTTDAKPEEETSSLEARPGDEPDNVEPKPTDEPDKVETQPGEVPDNIEPKPGDAPDNVEPQPGDETSKEGAANNGNEEEKMPIPSVVIEPASSNEGDDDRDGDITSPIATGDNGMIADCQTTKDSSGMPPRFLFKVETMHDFEAANPDELELKKGDIVLVVPTELAEDQDAGWLTGIRESDWQQRGASAKKGLFPENFTQRLE
Protein: Homeodomain-like transcriptional regulator (MYB transcription factor) (Putative I-box binding factor) (Similarity to Myb-related transcription factor) (Q9FIL9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- NAC domain containing protein 64
- Pentatricopeptide repeat-containing protein At5g15300
- AT5g43460/MWF20_18
- Transcription factor HHO3
- F-box/kelch-repeat protein SKIP6
- Uncharacterized calcium-binding protein At1g02270
- Probable RNA methyltransferase At5g51130
- Thioredoxin superfamily protein
Sequence:
MEVMRPSTSHVSGGNWLMEETKSGVAASGEGATWTAAENKAFENALAVYDDNTPDRWQKVAAVIPGKTVSDVIRQYNDLEADVSSIEAGLIPVPGYITSPPFTLDWAGGGGGCNGFKPGHQVCNKRSQAGRSPELERKKGVPWTEEEHKLFLMGLKKYGKGDWRNISRNFVITRTPTQVASHAQKYFIRQLSGGKDKRRASIHDITTVNLEEEASLETNKSSIVVGDQRSRLTAFPWNQTDNNGTQADAFNITIGNAISGVHSYGQVMIGGYNNADSCYDAQNTMFQL
Protein: Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Placental protein 25) (PP25) (Q9D6H2)
Organism: Mus musculus (Mouse)
Function: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:19253336}.
Interaction partners:
- Intraflagellar transport protein 27 homolog
- Intraflagellar transport protein 22 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 20 homolog
- Intraflagellar transport protein 88 homolog
- TRAF3-interacting protein 1
Sequence:
MRKVDLCSVTEGTEVILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFHKHVKIEKLVIQSYLVRTLRIEKTTSKEPLDFEQWVEKDLVHTEGQLQNEEIVARDGYATFLRFIIVSAFDHFASVHSISAEGLTVSSLP
Protein: Uncharacterized protein (Q386D1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGHSKETGRRVKKAKWKKQEGSRVVEKQTNHTVKNGQEKSKKSSQGNVDDRYVVVITNVENDFAKVHREAFPRFCCLDKKFERGCSSPSCEMERRTGTTSDASQGRAQCHYTVSARTETRSVEIAIYGKADGNVSTVFTPVPGKHAATLNGGKKSDDSAPVAKAKGKERHKREVEDDTIVECVYGLTGSGTRFDTLEDMVTSLSRKPYFTHPPKFLLNIAGNEDGAILKSPKGMKRSRESGEGEHSQSTPSVGGELRQSTVRQSEMVTASAATSSRIGAKELRQQLKDIPGFVTCWALYQQHFRLVFVSKAALFKAKHLLDQFEVDGSVRVSITLPDSAAKEFVNQLSAEENTI
Protein: Cholera enterotoxin subunit B (Cholera enterotoxin B chain) (Cholera enterotoxin gamma chain) (Choleragenoid) (P01556)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
Subcellular location: Secreted. Host cell membrane {ECO:0000305}.
Interaction partners:
- Cholera enterotoxin subunit A
- Zona occludens toxin
Sequence:
MIKLKFGVFFTVLLSSAYAHGTPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAIITFKNGAIFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAISMAN
Protein: Pumilio/PUF RNA binding protein 5, putative (Q57X89)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RNA-binding protein, putative
- RNA-binding protein, putative
- C3H1-type domain-containing protein
- RNA-binding protein, putative
Sequence:
MLRRGERLTMMAVPALNVPQSNVATQSACTHPFQVPQQCRSAWELTTSDSSPSLSAQGAATPKPAVSNTTNAAASAGCYRSHRYTHNPYASTAPRSDNDGADPVCVSGSGDGNCEAPRHVYNSAVLDSGNLSNGLVERFRAIVGELPRAACTSAGRNLLVSVLRLHHVEMTRTVVDEFRPVLPAVALDSNGCHVVRALVEFIPTGLMATLVPHFTPSLVRDLAVSSPYTRRVLQSVFERHKSDALTPIVEAIAQDSQLLAQRQQGCITIIRTIENTLPHQQRFIISRLLPALPALTMNCYGNYVVQCVLHHMDPEAVTVVVCHAFAGHWVALSCNKFASNVVEKVVRVLEGPARRALIAETVCDPVNLRRLMNDCFGNFVLQAIIDSSTSEVDFRTISQCIRPLLPTSSHGRRIESKLQCVMARAGAVGE
Protein: phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153) (O42391)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLLTIKHELFKEARKYPLYQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPICEFDMVKDPEVQDFRRNILNVCKEAVDLRDANAPHSRALYVCPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYTQLPLDTFTMPSYSRRISTATPYMNGEATAKSLWTINSALRIRILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLSYDMYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINMFDYTDTLVSGKMALNLWAVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSNPVKFPDMTVIEEHANWTISRELGFNYSYAGLSNRIARDNELRESDKEQLRAICTRDPLSEITEQEKDFLWSHRHYCVNTPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRAFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNQLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFISPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRSSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEMYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
Protein: Sperm-egg fusion protein TMEM95 (Transmembrane protein 95) (Q3KNT9)
Organism: Homo sapiens (Human)
Function: Sperm protein required for fusion of sperm with the egg membrane during fertilization.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P0DJF3}; Single-pass type I membrane protein {ECO:0000305}. Note=Following the acrosome reaction, relocalizes to the equatorial segment. {ECO:0000250|UniProtKB:P0DJF3}.
Interaction partners:
- Sperm acrosome membrane-associated protein 6
- Izumo sperm-egg fusion protein 1
- E3 ubiquitin-protein ligase DCST1
- Cilia- and flagella-associated protein 119
Sequence:
MWRLALGGVFLAAAQACVFCRLPAHDLSGRLARLCSQMEARQKECGASPDFSAFALDEVSMNKVTEKTHRVLRVMEIKEAVSSLPSYWSWLRKTKLPEYTREALCPPACRGSTTLYNCSTCKGTEVSCWPRKRCFPGSQDLWEAKILLLSIFGAFLLLGVLSLLVESHHLQAKSGL
Protein: Core gene UL37 family protein (ORF 63) (ORF63) (Q76RF5)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MDGTDALEKLTKGLSGGGGSLHQTKLLMEFQLRGLPVPALLNSSTTEQFLNTVAQLPTDLSKFIRDYRVFALVRAAYFLEPPSSIDPLEAARALGRLVDILSSQPPQNTAPAQPPTSDDTLNNCTLLKLLAHYADQIAGFKTPALPPVPPGIIGLFTCVEQMYHACFQKYWAAALPPMWILTYDPPTSPLQDWLIVAYGNKEGLLLPSGIPSEEVLAKTLVTEHHELFVSRSNSTETAVTMPVSKERALAIYRVFAKGEVVAENTPILAFTDVELSTLKPHYLFIYDFIIEALCKSYTYSCTQARLESFLSRGIDFMTDLGQYLDTATSGKQQLTHSQIKEIKYRLLSCGLSASACDVFRTVIMTLPYRPTPNLANLSTFMGMVHQLTMFGHYFYRCLGSYSPTGLAFTELQKILTRASAEQTERNPWRHPGISDIPLRWKISRALAFFVPPAPINTLQRVYAALPSQLMRAIFEISVKTTWGGAVPANLARDIDTGPNTQHISSTPPPTLKDVETYCQGLRVGDTEYDEDIVRSPLFADAFTKSHLLPILREVLENRLQKNRALFQIRWLIIFAAEAATGLIPARRPLARAYFHIMDILEERHSQDALYNLLDCIQELFTHIRQAVPDAQCPHAFLQSLFVFQFRPFVLKHQQGVTLFLDGLQTSLPPVISLANLGDKLCRLEFEYDSEGDFVRVPVAPPEQPPHVHLSHFKKTIQTIEQATREATVAMTTIAKPIYPAYIRLLQRLEYLNRLNHHILRIPFPQDALSELQETYLAAFARLTKLAADAANTCSYSLTKYFGVLFQHQLVPTAIVKKLLHFDEAKDTTEAFLQSLAQPVVQGQRQGAAGGSGVLTQKELELLNKINPQFTDAQANIPPSIKRSYSNKYDVPEVSVDWETYSRSAFEAPDDELRFVPLTLAGLRKLFVE
Protein: Carboxyl-terminal protease (EC 3.4.21.-) (Q729L4)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Peptidase, M23/M37 family
- Pyruvate:ferredoxin oxidoreductase
Sequence:
MRVTLWVVSLGLCAAVAFSGGAVFATTEESKYDALKRFSQVLDIVERYYVRDVPRKDLMNGAVKGMLQGLDPHSTFLSPEEFKEMQETTSGEFFGIGIEISSENGQLTVVSPIEDTPAFKAGLKAGDLILAVDGQPTQEMSTQEAVSRIRGPKGSEVELLILHREAKAPSTVKIVRDAIPLVSVKSKQLEQGYVWVRLTRFSERTTSDLLEALREANKRGPVKGVVLDLRNNPGGLLDQAVSVSDVFLRDGGIVSIRGRGDDTGREYNAKAQSTDVTAPMVVLINAGSASASEIVAGALRDQKRALLVGERSFGKGSVQNVIPLSDGAGLKLTVALYYTPNGRSIQAEGIDPDIEIPFEAPREDDAKPMQRFNMLREKDLSRHLENGAGGKQGKNDQSDEVRDLLERDNQLRMALQFVKRLPALKEIR
Protein: DNA-directed RNA polymerases I and III subunit RPAC1 (RNA polymerases I and III subunit AC1) (C37) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (AC40) (C40) (P07703)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I (Pol I) and III (Pol III) which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPC40 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft. Plays an important role in targeting retrotransposons Ty integration upstream of pol III-transcribed genes such as tRNA genes, allowing Ty1, Ty2 and Ty4 to proliferate and yet minimizing genetic damage.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA-directed RNA polymerase I subunit RPA12
- DNA-directed RNA polymerase I subunit RPA34
- DNA-directed RNA polymerase III subunit RPC8
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerase III subunit RPC7
- DNA-directed RNA polymerase I subunit RPA43
- DNA-directed RNA polymerase I subunit RPA49
Sequence:
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINIDTSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNLPDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFADCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIKGESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIFNVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ
Protein: Pyruvate dehydrogenase E1 component subunit alpha (EC 1.2.4.1) (Q7YU05)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQTIRRLETAAGNLYKEKIIRGFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCARGKGGSMHMYAPNFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAYLWKLPVIFVCENNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINYVNTHGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDLKVRKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRGTIAYDIDHIQERKGVNH
Protein: Mitochondrial import receptor subunit TOM5 homolog (Q8N4H5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:18331822}; Single-pass membrane protein {ECO:0000269|PubMed:18331822}.
Interaction partners:
- Mitochondrial import receptor subunit TOM7 homolog
- Mitochondrial import receptor subunit TOM6 homolog
- Mitochondrial import receptor subunit TOM40 homolog
- Mitochondrial import receptor subunit TOM22 homolog
- Mitochondrial import receptor subunit TOM70
- Mitochondrial import receptor subunit TOM20 homolog
- Mitofusin-1
- Stress-70 protein, mitochondrial
- MICOS complex subunit MIC13
- Mitochondrial import receptor subunit TOM40B
Sequence:
MFRIEGLAPKLDPEEMKRKMREDVISSIRNFLIYVALLRVTPFILKKLDSI
Protein: Group XIIB secretory phospholipase A2-like protein (Group XIII secretory phospholipase A2-like protein) (GXIII sPLA2-like) (sPLA2-GXIIB) (GXIIB) (Q99P27)
Organism: Mus musculus (Mouse)
Function: Not known; does not seem to have catalytic activity.
Subcellular location: Secreted.
Interaction partners:
- Group IIC secretory phospholipase A2
- Group 10 secretory phospholipase A2
- Group IIF secretory phospholipase A2
- Group IIE secretory phospholipase A2
- Group 3 secretory phospholipase A2
- Group IID secretory phospholipase A2
- Phospholipase A2
- Phospholipase A2 group V
- Cytochrome P450 2E1
- Polyunsaturated fatty acid lipoxygenase ALOX8
Sequence:
MKLLCGFFLLWLGLVGNLAQSDPSPKEEESYSDWGLRQLRGSFESVNSYVDSFMELLGGKNGVCQYRCRYGKAPMPRPGYKAQEPNGCSSYFLGIKVPGSMDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRTLGFVSNVEAACDSLADTVFNTVWTLGCRPFMNSQRAACICAEEEKEEL
Protein: Schlafen 4 (Q3UV66)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAGNTPQLEKDVNPQTSIEPSVQVKCPGDILQGGRHAKRGRWMASWKGFHLGRRDSDCKMNITVDQDTDYAELVLSVGEITLGEKTRDSMKDSQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDGMGLDLVNPLPGILHLPHDYLDFMQYNDYFFVFVKPWKPNQRGPGIATWKTNLYKRIFSFSVELKAADAVQFLKSRPSSHGKTVCNETLNECLSLFNRDWLAYEETFCFTKSTHAEVKLTPKEKISPKEKILELLPQTVSAFANTDGGYLFIGLDGKTQQIIGFEAEKSDLVLLESEIEKCIQQLPVTHFCEEKEKIKYTCKFIEVHKSGAVCAYVCAIRVEKFCCAVFAAEPESWHVEGSCVKRFTTEEWVKRQMDATAVMPGKVICSPEALCMKPFSQHEGYEQLVRTELGSLRKGTLVVSKSWALDLGLQEKQEVIWDVLHISQGSLLTLHVFVQGDENLEGNSSLLGKLGAELKGYYKQIALTLKQTLVNHCGYTAKIGIIVKITYLGHKTMCLYDSSAKICYPQIYYLTTKAVKDLEKALAEILGSYESFYSLPRRNWDSFMSAFLNVGSYIVYFSRNVLTHIRI
Protein: DNA polymerase IV 1 (Pol IV 1) (EC 2.7.7.7) (P9WNT3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Protein RecA
- Beta sliding clamp
- LexA repressor
- Probable bifunctional transcriptional activator/DNA repair enzyme AlkA
- DNA polymerase I
- Putative lipoprotein LppK
- Error-prone DNA polymerase
- Probable DNA polymerase III
- UvrABC system protein B
- Uncharacterized protein Rv3395c
Sequence:
MESRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARAYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIASRRVFDTVRGLVPVVEQLSFDEAFAEPPQLAGAVAEDVETFCERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVRHAEEQALLSGLPVRRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALHRLARGIDDRPVVERAEAKQISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRDGRGARTITVKLKKSDMSTLTRSATMPYPTTDAGALFTVARRLLPDPLQIGPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAHYVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGHGVVTVRFETRGSGPGSARTFPVDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDVGDR
Protein: Mind the gap, isoform E (A0A0C4DHF5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNFFVIGFLIMQAARLACGTCVLSSDFGFILDCNFKKSGLFRVRNLGGLKAHFGLGFSLGDELGFPESLGNTESDRRRAISYKNGAPPDLVGVLPSTQQQVNPPVQHPLPEKRISSRSTGAAPYNLQQVQQQQQLQLQQQKLQQQQLQQQLKLKQLLLLQQQQQQQQQLMTEARPLPLGVPAFRPIPQKQLAATQPSAPSSTPAERRVAVDTPEPRVSVNNKLVSSIDQPHSNRTFHVANPVVSQPVAVPVFQAMPQSIARIANVGKEHRTVSSHPNYLQFEEPKFDLKDVTVEELAAAANVTVDTIKHAIYVREQQLKAEHRAQLAAKLREEFMRTSTVRTTTTTTTTTTTTPRPQKSLAEHKVSKVMNAPKEYYPVGYDKNFDDNFKSKVDLPPTSFSCAKQKHFPGLYADTDLGCMVFHVCALTDDGMVRKSFLCPENTLFDQTILKCNWWFYVDCSSSTSVYDSNIPISKSYQLMKSLTYFSKYAGGQRHEQGGDKDENALDIDSLRESMEGVARRQEQAKKAELRVEEQRSMPKEDHEHVVPAEAEQQLSN
Protein: Regenerating islet-derived protein 3-beta (REG-3-beta) (Pancreatitis-associated protein 1) (Peptide 23) (REG-2) (Regenerating islet-derived protein III-beta) (Reg III-beta) [Cleaved into: Regenerating islet-derived protein 3-beta 16.5 kDa form; Regenerating islet-derived protein 3-beta 15 kDa form] (P25031)
Organism: Rattus norvegicus (Rat)
Function: Bactericidal C-type lectin which acts against several intestinal Gram-positive bacteria and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P35230}. Note=Found in the apical region of pancreatic acinar cells. {ECO:0000250|UniProtKB:P35230}.
Interaction partners:
- Regenerating islet-derived protein 3-alpha
- Interleukin 22
Sequence:
MLHRLAFPVMSWMLLSCLMLLSQVQGEDSPKKIPSARISCPKGSQAYGSYCYALFQIPQTWFDAELACQKRPEGHLVSVLNVAEASFLASMVKNTGNSYQYTWIGLHDPTLGGEPNGGGWEWSNNDIMNYVNWERNPSTALDRGFCGSLSRSSGFLRWRDTTCEVKLPYVCKFTG