wanglab/gogpt-training-data huggingface dataset:
Protein: Integrin alpha-PS2 (Position-specific antigen subunit alpha-2) (Protein inflated) [Cleaved into: Integrin alpha-PS2 heavy chain; Integrin alpha-PS2 light chain] (P12080)
Organism: Drosophila melanogaster (Fruit fly)
Function: Alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Involved in the function and/or development of the olfactory system.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:19035354}; Single-pass type I membrane protein {ECO:0000269|PubMed:19035354}. Lateral cell membrane {ECO:0000269|PubMed:19035354}; Single-pass type I membrane protein {ECO:0000269|PubMed:19035354}. Basal cell membrane {ECO:0000269|PubMed:19035354}; Single-pass type I membrane protein {ECO:0000269|PubMed:19035354}. Note=During mid-oogenesis, localizes to the apical, to the lateral and to the basal membranes of follicle cells. Apical membrane localization peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte while decreases in the most posterior follicle cells. During embryogenesis, at the end of germband extension concentrates at the basal membrane of mesodermal cells, where they adhere to the ectoderm. Then, in visceral mesoderm localizes basally, whereas in somatic mesoderm is homogenously distributed.
Interaction partners:
- Integrin beta-PS
- Integrin alpha-PS1
- Integrin beta-nu
- Integrin alpha-PS3
- Integrin alpha-PS4
- Integrin alpha-PS5
- Teneurin-m
Sequence:
MSGDSIHRRRMALHCPITSLILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNRWNMANIFNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLFGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQGHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHTGTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMVAKTMEKLASNVPLNVSTLAVANVTLLPFIGAPKDAIVKTHEIFYKAEPEPLQVPDVVPLWVVVLAACAGALIFLLLVWLLYKCGFFNRNRPTDHSQERQPLRNGYHGDEHL
Protein: Growth arrest-specific 7 (Growth arrest-specific protein 7a) (K4KDS6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Intersectin-2b
- Intersectin 2a.
- Actin filament-associated protein 1
- Calcium load-activated calcium channel
- Opioid growth factor receptor-like 1
- Cyclin G-associated kinase.
- GDP-mannose 4,6 dehydratase
- WD repeat domain 36
- Transforming growth factor beta receptor type 3 precursor
Sequence:
MEMEESFDAEGSFDDPSYLSPQSPGSTSPARRQNKEIKETKITINCVTFPVSTSTPEQELLKPNEWSYCDYFWTDKRDLQGATVTGFEVLLQKQLKGKQMQKEMAEFIRERIKIEEEYAKNLSKLSMFPMAAQEEGTLGEAWAQLKKSLADEAEVHLKFSSKLQSEVEKPLLTFRGDNFKKDMKKYDHHIADLRKQLVSRYAAVEKARKALADRQKDLEVKTQQLEIKLSNKSEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTSMELEKLEVERIEMIQQHLRQYTTLRHETDMFNQSTLEPVDQLLQSVDPAKDRELWVKEHKTGDRRPVDMDI
Protein: 20S proteasome beta subunit E1 (F4HP14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKLDTSGFETSMPMIGFGSSSDMLDELSSVPSFDLPRTKEFDGFQKKAKDMLKHAKGTTTLAFIFKGGVMVAADSRASMGGYISVSSLKNSSKNMHPFDIVDFGRNTTSQSVKKIIEINPYMLGTMAGGAADCQFWHRNLGIKCRLHELANKRRISVSGASKLLANMLYSYRGMGLSVGTMIAGWDETGPGLYYVDNEGGRLKGDRFSVGSGSPYAYGVLDSGYKYDMSVEEASELARRSIYHATFRDGASGGVASVYHVGPEGWTKLSGDDVGELHYHYYPVAPATAEQVMEEATAE
Protein: PHO4-like protein (C8V3P3)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MEQDPSMSWSDMPPPGEDDFSNFLEFGFPDLEGQHGPTDHFPSRSVAQAAAMATSTAPPQQQQVVCMNSDGVSDQSQSYNRMPGDFPVELPGQGQQGMLHNSSYSNGPMTPAFYAQKPQMFHSSQQQQPVQPQSSQPYNPQGQMMIPPTPNSIELHGNAAPYPQRVGDNSEMYDRYTRMMEEQALYTPLVSPAMTPLESQFRQPEYTIPGEYFSPLSSPAIEAQHPNPNGFPIHSGPLTEVNFVHSPVDNAFPLSSAPPSPGLARKYKRRSSAASKTFQSRAKKQQSPSVRPLARTRSRLTDEVMTTLSEGQINPTPNPPQNGSRSHFGSAESSGQDSVSPEPLSEPLMPPPALPPSRKSPAIAPQARQQQNPSEPATPAMLMRMQRSPLARSAPDHNLTPTQRPMNQVQDEVMEDVILPEAANPSAQLFRPQVARIDTAMPTSTSSQGVSLNATAHSAPHQVSLSEKPPASIAPSPRTAAMPSPSGPVPKKSDTPKLGPVSRKRQSLSSSHPSPSLRPKISPNIQPLVAGDTSAAYLAGIKSNYQQILEGTLLPGVSYPETLAENLSSKRTNHKLAEQGRRNRINTALKEIETLIPAAYVQMRLHKEAATCNGKGEKEKERTGNQPISKASTVEMAIDYIKSLKAELDATKVKLAAAEAKLGTSETAKEAHGSNGQQNEEKAVDEINTTDRTSDPNNAQSSTAGES
Protein: RecQ-mediated genome instability protein 1 (Q57ZC8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RecQ mediated genome instability protein 1 OB-fold domain-containing protein
- DNA 3'-5' helicase
Sequence:
MEQPSAEFLNSNFEYLASLDPPGVVRQLPPLHDGGGLLPHDFQLSVPEGAIGQKIVPSIILQVNEVADVSLPLAQRLREIAPTGADTEGVCTEITEPGSLEETLRSLESKDNSARHHGRRQRLLRLVLTDGFVRVFAVEDCRRGCDALRTGVVLGSKLRLFAPLRLLNGVIILESEKTELLGGFVKEIQSFWEDYAVKKLHELSGRPGRIAQASSATNMNTNTNTATFSSAPAPRIAGDTNHSGVAPGPTQQQHQKQHQKQHQKQQQRQQQQQQLLEYRHQTNEGVSGPVVQPSPPAAASAQPTPPTRPAARLTPTPEPLSHPRVTQEYFVPATPTPEQPPTATPPFSTAIGKITDVMSDLTIRDGENCSPGEPPSFSLKVLLSVQQPLTPSLDVGEDGAIVVDLGNAWLQRALGMNVASFRSLTSSQLPNDLARINQLVDEVGRTLENFGIAEFHIRRRLSDGILEVVHVRQLE
Protein: Photosystem I reaction center subunit N, chloroplastic (PSI-N) (P49107)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function in mediating the binding of the antenna complexes to the PSI reaction center and core antenna. Plays an important role in docking plastocyanin to the PSI complex. Does not bind pigments.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:18431481}; Peripheral membrane protein; Lumenal side.
Interaction partners:
- Photosystem I reaction center subunit XI, chloroplastic
- Photosystem I reaction center subunit psaK, chloroplastic
- Photosystem I reaction center subunit III, chloroplastic
- Photosystem I reaction center subunit V, chloroplastic
- Photosystem I chlorophyll a/b-binding protein 3-1, chloroplastic
- Chlorophyll a-b binding protein 6, chloroplastic
- Photosystem I P700 chlorophyll a apoprotein A1
- Chlorophyll a-b binding protein 4, chloroplastic
- Photosystem I reaction center subunit VI-2, chloroplastic
- Photosystem I chlorophyll a/b-binding protein 2, chloroplastic
Sequence:
MAAMNSSVLTCSYAIAGSGSVELNQKVGLVNSSVGFGQKKQMIMPVIKAQRVVGDDVDGSNGRRSAMVFLAATLFSTAAVSASANAGVIDEYLERSKTNKELNDKKRLATSGANFARAFTVQFGSCKFPENFTGCQDLAKQKKVPFISEDIALECEGKDKYKCGSNVFWKW
Protein: Ribosomal protein S6 kinase (EC 2.7.11.1) (A0A384MDW3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL
Protein: SAFB like transcription modulator (H0YL55)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKDSEASKPKDGQDAIAQSPEKESKDYEMNANHKD
Protein: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) (Q9VHJ8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03220}.
Interaction partners:
Sequence:
MASFLARTGGPLIETVRPAAIKKILGLAPIAVQQLRNLNVQEHVSYSLLNEAKIPTPRFAVAKNGKEANDIATKLKTDNLVLKAQVLAGGRGKGTFKNGLKGGVRVVYDPQTAEELSSKMIDQLLVTKQTGAAGRICKKVMVAERKFPRREFYFAVMMERAFNGPVLIASKEGGVDIEEVAASSPDAILYEPIDIGTGLTSEQAEKIVKKVGLGGDGEDTHVQMLLNLYDLFVKKDALLVEINPYAEDAMSGFFALDAKLRFDDNAEFRQKELFALRDWTQEDPKEVEAAKYNLNYIALDGTIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGATAEAVKAAFKIITSDPKVLCILVNIFGGIMRCDVIAEGIISATKDLNLNMPVVVRLQGTKVKEARELIRTSGLKILARDDLDKAADLAVHLAQIVKLAREMKMDVNFEIPDAQKGKGDCKKDQKQPDSKGGKKSEKKDDKKSDCTKKEEKKKEEKKDICEKKGKK
Protein: Protein TIC 214 (Translocon at the inner envelope membrane of chloroplasts 214) (AtTIC214) (P56785)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000269|PubMed:23372012}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein TIC 100
- Protein TIC 56, chloroplastic
- Protein Ycf2
- Chloroplastic ATP-dependent Clp protease proteolytic subunit 1
- DNA-directed RNA polymerase subunit beta''
- Photosystem I assembly protein Ycf3
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic
- DNA-directed RNA polymerase subunit alpha
- Maturase K
- DNA-directed RNA polymerase subunit beta'
Sequence:
MMVFQSFILGNLVSLCMKIINSVVVVGLYYGFLTTFSIGPSYLFLLRARVMDEGEEGTEKKVSATTGFIAGQLMMFISIYYAPLHLALGRPHTITVLALPYLLFHFFWNNHKHFFDYGSTTRNEMRNLRIQCVFLNNLIFQLFNHFILPSSMLARLVNIYMFRCNNKMLFVTSSFVGWLIGHILFMKWVGLVLVWIQQNNSIRSNVVIRSNKYKFLVSELRNSMARIFSILLFITCVYYLGRIPSPIFTKKLKGTSETGGTKQDQEVSTEEAPFPSLFSEEGEDLDKIDEMEEIRVNGKDKINKDDEFHVRTYYNYKTVSENLYGNKENSNLEFFKIKKKEDHFLWFEKPFVTLVFDYKRWNRPNRYIKNDKIENIVRNEMSQYFFYTCQSDGKERISFTYPPNLSTFFEMIQKRIPSFTKEKKTFDQVSTYWSLIHEEKRENLKKEFLNRIEALDKEWSVENILEKTTRFCYNEAKKEYLPKIYDPFLHGISRGRIKKLPPFQIITETYRKNNLGGSWINKIHGLLLKINYKKFEQTIEKFNRKSLSIEKKLSFFSEPQQEEKINSEEEIKTFKFLFDIVRTDSNDQTLIKNFMDFPEINKKVPRWSYKLISELEELEGENEENVPMEPGIRSRKAKRVVVFTDKEPHGEIYTNLKDNQNSDQNDEMALIRYSQQSDFRREIIKGSMRSQRRKTVIWEFFQAKVHSPLFFDRIDKLFFFSFDIWGLKKKIIKNFIWKKKIDKKEEEQSKREETRRIEIAETWDSFLFAQIIRGSLLVTQSILRKYIILPLLIIIKNSVRMLLFQFPEWSQDLKDWKREMHVKCTYNGVQLSETEFPRNWLTDGIQIKILFPFYLKPWHKSKFQASQKARLKKTKDKGEKNDFCFLTVWGMETELPFGSAQRKPSFFEPISKELKKRIKKLKKKSFVVLKIFKERAPIFLKVAKETKNWILKNFIFIKGISKRNLIPLFGPREIYELNEPKKDSIISNQMIHELSVQNKSLEWTNSSLSEKKIKNLIDRKKTIRNQIEEISKEKQNLTNSCTKLRYDSKIIESSKKIWQTFKRKNTRLIRKSIFFFKFCIEQMSIAIFLGIINIPRITTQLFFESTKKILDKYIYKNEENGEKKKNTLYFISTIKNLISNKKKMSYDLCSLSQAYVFYKLSQIKVSNFCKLKAVLEYNICITSFFVKNKIKVFFQEHGIFHYELKNKTFLNSEVNQWKNWLRSQYQYNLPQISWARLVTQNWKNKINKDSLVLNPSLTKEDSYEKKKFDNYKKQKFFEADSLLNPKHNVKKDSIYNLFCYKSIHSTEKNFDMSIGIALDNCLVSSFLEKYNIRGMGEIRHRKYLDWRILNFWFTKKVTIEPWVDTKSKKKYINTKVQNYQKIDKITQTDLANKKRNFFDWMGMNEEILNQRITNFEFFFFPEFFLFSSTYKMKPWVIPIKLLLLNFNENINVNKKIIRKKKGFIPSNEKESLRFYNLNKEEKESAGQVELESDKETKRNPEAARLNQEKNIEENFAESTIKKRKNKKQYKSNTEAELDLFLTRYSRFQLRWNCFFNQKILNNVKVYCLLVRLNNPNEIAVSSIERGEMSLDILMIEKNFTFAKLMKKGILIIEPVRLSVQNDGQLIIYRTIGISLVHKNKHKISKRYKKKSYINKKFFEKSITKYQNKTVNKKKNNYDFFVPEKILSPKRRREFRILICFNLKKKNARDTNSRFDKNIQNLTTVLHKKKDLDLDKDKNNLINLKSFLWPNFKLEDLACMNRYWFNTTNGNHFSMIRIRMYTRFPIP
Protein: Palmitoyltransferase ZDHHC23 (EC 2.3.1.225) (DHHC-containing protein 11) (Zinc finger DHHC domain-containing protein 23) (DHHC-23) (zDHHC23) (Q5Y5T3)
Organism: Mus musculus (Mouse)
Function: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes. Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8IYP9}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q8IYP9}; Multi-pass membrane protein {ECO:0000255}. Note=Neuronal soma and dendrites. {ECO:0000250|UniProtKB:Q76IC6}.
Interaction partners:
- Palmitoyltransferase ZDHHC22
- Zinc finger protein 69
Sequence:
MKPVKKKKTEEPELEPLCCCEYIDRNGEKNHVAACLCDCQDLDEGCDRWLTCQSLRPETCERITDTISDRLRIPWLRGAKKVNISIVPPLVLLPVFLHVASWHFLLGVVVLTSLPMLALWYYYLTHRRKEQTLFFLSLGLFSLGYMYYVFLREVVPQGRVGPTQLALLTCGLLLILLALYRAKKNPGYLSNDKSPSNSQIECPVKKGQEKTKGFPGTDASGSLNNRTLKDDVRGSSRVGLDSPAKVKEDWCAKCQLVRPARAWHCRICGICVRRMDHHCVWINSCVGESNHQAFILALSIFLLTSVYGISLTLNTICRDRSLFTALFYCPGVYANYSSALSFTCVWYSVIITAGMAYIFLIQLINISYNVTEREVQQALRQKTGRRLLCGLIVDTGQYNRGFLRNWLQFSTLGTHTVHTPAEDIV
Protein: Probable S-adenosylmethionine synthase 3 (AdoMet synthase 3) (EC 2.5.1.6) (Methionine adenosyltransferase 3) (MAT 3) (P50305)
Organism: Caenorhabditis elegans
Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Interaction partners:
- Hcy-binding domain-containing protein
- Probable methionine synthase
- Tyrosine aminotransferase
- S-adenosylmethionine decarboxylase proenzyme
- Probable methylenetetrahydrofolate reductase
- PABS domain-containing protein
- Serine hydroxymethyltransferase
- Trifunctional purine biosynthetic protein adenosine-3
- U6 small nuclear RNA
- Alanine--glyoxylate aminotransferase
Sequence:
MSQHKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDSDDVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQVTIEYASEGGACVPLRVHTVVISTQHSPDISLDDLRKELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKSGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALNEGELLKIVNDNFDLRPGMIIKDLDLKKPIYEPTAENGHFGHNEFPWEQPRHLQIDVELLKKIGGKTISNGNGIAH
Protein: N-acetylgalactosaminide beta-1,3-galactosyltransferase (EC 2.4.1.122) (Q9VQH6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MGVRPNRKRLELMLMLLIGLAWGILLSELMKRTRWQNHADRLKEESSPFPSSQRSRNLRTPPTIAPSTTNPPPDILAARLFNETRVLCMVLTSPKTHHTRAIHIKRTWGRRCNKLIFMSTKADKELGSVALNVREGYSNLWPKTRAALQYVYKHHFQKYDWFLKADDDTYFIMENLRAFLHAHNFREPVYFGNKFRQHVKEGYMSGGAGYVLSKMALHRLIKLGFSNSSICTNRNYGYEDVELGRCLAGVGVVGGDSRDEQGLSRFIPFSPLHWYPQPPDWYQPLLYYTSPDNSSDCCSNTAISFHYNNAQEFYVLEYIIYKLRIFGINRELGPLPKKKASSRPMSINLQTTKEENGHIALIKMMPRKNVTTPNYRTKTTSKFKK
Protein: Nucleolin (Protein C23) (P09405)
Organism: Mus musculus (Mouse)
Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P19338}. Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.
Interaction partners:
- Nucleophosmin
- 4-hydroxyphenylpyruvate dioxygenase
- Heterogeneous nuclear ribonucleoprotein K
- Y-box-binding protein 1
- rRNA 2'-O-methyltransferase fibrillarin
- Heterogeneous nuclear ribonucleoprotein U
- Midkine
- Calreticulin
- Collagen alpha-1
- Calreticulin
Sequence:
MVKLAKAGKTHGEAKKMAPPPKEVEEDSEDEEMSEDEDDSSGEEEVVIPQKKGKKATTTPAKKVVVSQTKKAAVPTPAKKAAVTPGKKAVATPAKKNITPAKVIPTPGKKGAAQAKALVPTPGKKGAATPAKGAKNGKNAKKEDSDEDEDEEDEDDSDEDEDDEEEDEFEPPIVKGVKPAKAAPAAPASEDEEDDEDEDDEEDDDEEEEDDSEEEVMEITTAKGKKTPAKVVPMKAKSVAEEEDDEEEDEDDEDEDDEEEDDEDDDEEEEEEEPVKAAPGKRKKEMTKQKEAPEAKKQKVEGSEPTTPFNLFIGNLNPNKSVNELKFAISELFAKNDLAVVDVRTGTNRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGRDSKKVRAARTLLAKNLSFNITEDELKEVFEDAMEIRLVSQDGKSKGIAYIEFKSEADAEKNLEEKQGAEIDGRSVSLYYTGEKGQRQERTGKTSTWSGESKTLVLSNLSYSATKETLEEVFEKATFIKVPQNPHGKPKGYAFIEFASFEDAKEALNSCNKMEIEGRTIRLELQGSNSRSQPSKTLFVKGLSEDTTEETLKESFEGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDFKPQGKKTKFE
Protein: Calnexin homolog (O82709)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MVDRKEIPLAMGLLAVLLFFVASSSSFHLVRASDEVDDAIFYESFDEDFDNRWIVSGKEEYNGVWKHSKSEGHDDFGLLVSEPARKYAIVKELDAPVSLKDGTVVLQFETRLQNGLECGGAYIKYLQTQESGWKPKGFDNESGYSIMFGPDRCGATNKVHFIFRHKNPKTGKHVEHHLKFPPSVPSDKLSHVYTAVLKDDNEVSILIDGEEKKKANFLSSEDFEPALIPSKTIPDPDDKKPEDWDERAKIPDPEAVKPEDWDEDAPREIIDEEAEKPEPWLDHEPEVDDPEAKPEDWDDEEDGEWEAPKIENPKCEAAPGCGEWKRPTKSNPAYKGKWSAPYIDNPNYKGIWKPQEIPNPEYFELEKPDFEPIAAIGIEIWTMQDGILFDNVLIAKDDKIAESYRETTWKPKFNIEKEKQKHEEEAAAAAAARSESEGIAGIQKKAFDLLYKIADIAFLSGQKEKIIEIIEKGEKQPNLTIGIIVSVVIVFVSIFFRLIFGGKKPANVEANVEKKKTNTETTSKQDGGEKEDNKEKEETANPPRRRPKRDN
Protein: Homer protein homolog 1 (Homer-1) (VASP/Ena-related gene up-regulated during seizure and LTP 1) (Vesl-1) (Q9Z2Y3)
Organism: Mus musculus (Mouse)
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24153177}. Postsynaptic density {ECO:0000269|PubMed:24153177}. Synapse {ECO:0000269|PubMed:24153177}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z214}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. The N-terminal of isoform 2 may facilitate trafficking of the complex with GRM5 from the endoplasmic reticulum (ER) to the plasma membrane (PM).
Interaction partners:
- Metabotropic glutamate receptor 1
- SH3 and multiple ankyrin repeat domains protein 3
- SH3 and multiple ankyrin repeat domains protein 1
- Homer protein homolog 2
- Metabotropic glutamate receptor 5
- Disks large homolog 4
- Homer protein homolog 3
- Glutamate receptor ionotropic, NMDA 1
- Vesicular glutamate transporter 1
- Disks large-associated protein 1
Sequence:
MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFPHSAGDRTQALSHASSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHSHKTELNQTVQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRSNLKTLLEILDGKIFELTELRDNLAKLLECS
Protein: Cell division control protein 10 (P25342)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
Subcellular location: Membrane {ECO:0000269|PubMed:14562095}; Peripheral membrane protein {ECO:0000269|PubMed:14562095}. Bud neck {ECO:0000269|PubMed:14562095}. Note=Present at the bud neck during cell division. Probably interacts with phosphoinosides such as phosphatidylinositol 4-phosphate or phosphatidylinositol 5-phosphate.
Interaction partners:
- Cell division control protein 12
- Cell division control protein 3
- Cell division control protein 11
- Seventh homolog of septin 1
- Serine/threonine-protein kinase GIN4
- Sporulation-regulated protein 3
- Sporulation-regulated protein 28
- Probable serine/threonine-protein kinase KCC4
- Protein BNI4
- Bud site selection protein 4
Sequence:
MDPLSSVQPASYVGFDTITNQIEHRLLKKGFQFNIMVVGQSGLGKSTLINTLFASHLIDSATGDDISALPVTKTTEMKISTHTLVEDRVRLNINVIDTPGFGDFIDNSKAWEPIVKYIKEQHSQYLRKELTAQRERFITDTRVHAILYFLQPNGKELSRLDVEALKRLTEIANVIPVIGKSDTLTLDERTEFRELIQNEFEKYNFKIYPYDSEELTDEELELNRSVRSIIPFAVVGSENEIEINGETFRGRKTRWSAINVEDINQCDFVYLREFLIRTHLQDLIETTSYIHYEGFRARQLIALKENANSRSSAHMSSNAIQR
Protein: WAT1-related protein At2g40900 (F4IJ08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Amino acid permease 2
- Protein GLUTAMINE DUMPER 1
- Amino acid permease 8
- Amino acid transporter ANT1
- Amino acid permease 1
- Amino acid permease 3
- Amino acid permease 5
- Plasmodesmata-located protein 6
- Plasmodesmata-located protein 8
- Plasmodesmata-located protein 7
Sequence:
MGLRMSESAKPYFAMVCLQFGYAGMNLVTKTVLDRGMSHYVLVAYRNAFATAAIAPFALLSERKVRSKMTFPIFMRIFLLALLGPVIDQNLYYIGLKLTSPTFSSAVSNIVPAITIILATLFRMEKVEMRKVRCLVKVMGTLVTVVGSILMIFYKGPFINFFRSHLTAASSPPTADYLKAAVFLLLASLSWASFFVLQAATLKKYSAHLSMSTMVCFMGTLQSLALAFVMEHNPSALNIGFDMNLLASAYAGIMSSSIAYYVQGLMMQRKGPVFVTAFNPLIVVIVSIMSFFVLGQGIYLGGVIGVVVLMVGVYAVLWGKHVDDDGEETRHEDNVVAVKCCSGNNGLTIMPKIDEADEEDVETGKATSEKESSVPEVVVVVFCSENVHSVSRPN