wanglab/gogpt-training-data huggingface dataset:
Protein: Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57) (P49441)
Organism: Homo sapiens (Human)
Function: Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism.
Interaction partners:
- Inositol monophosphatase 2
- Inositol monophosphatase 1
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
- Inositol-tetrakisphosphate 1-kinase
- Inositol polyphosphate-4-phosphatase type I A
- Inositol polyphosphate-5-phosphatase A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- Inositol polyphosphate 4-phosphatase type II
- Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Sequence:
MSDILRELLCVSEKAANIARACRQQEALFQLLIEEKKEGEKNKKFAVDFKTLADVLVQEVIKQNMENKFPGLEKNIFGEESNEFTNDWGEKITLRLCSTEEETAELLSKVLNGNKVASEALARVVHQDVAFTDPTLDSTEINVPQDILGIWVDPIDSTYQYIKGSADIKSNQGIFPCGLQCVTILIGVYDIQTGVPLMGVINQPFVSRDPNTLRWKGQCYWGLSYMGTNMHSLQLTISRRNGSETHTGNTGSEAAFSPSFSAVISTSEKETIKAALSRVCGDRIFGAAGAGYKSLCVVQGLVDIYIFSEDTTFKWDSCAAHAILRAMGGGIVDLKECLERNPETGLDLPQLVYHVENEGAAGVDRWANKGGLIAYRSRKRLETFLSLLVQNLAPAETHT
Protein: Decorin (Bone proteoglycan II) (Q803T1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|PIRNR:PIRNR002490, ECO:0000256|RuleBase:RU364097}.
Interaction partners:
Sequence:
MKSACLSLLLVSVCWALPFRQSGFMDFVMEDEPASGDGPGPELPTTRKPHVERLPMMPEGPEVPFCPFRCQCHLRVAQCSDLGLKTVPEKIPLDTTLLDLQNNKITEIKENDFKGLKGLQTLILVNNKITIIHAKAFSSLINLERLYLSKNLLKEVPANIPKSLQELRIHENQINKIKKSSFAGMANVIVMELGSNPLSSSGVDNGAFADLKRVSYIRIADTNLTSIPKGLPSSLFELHLDGNKITKVTADSLKGLKNLSKLGLSHNEISVVENGSLANVPHLRELHLENNALTAVPAGLADHKYIQVIYLHSNKIAAVGTEDFCPPGYNTKKAMYSGISLFSNPVPYWEVLPITFRCVFDRSAIQLGNYRKK
Protein: Neuregulin 1 (Pro-neuregulin-1, membrane-bound isoform isoform IIa) (A0A0R4IDP7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAILPGRSSSLTVSVLYGAAVCLSLWTRVVRCGSFACSPPGASVQELARRSGVVFEGKLQEEERAERNWTETPMNASRQVRVRVQQVWQLKAGGLIKDSVVSLVWFEGGRCFQLNTGIRYMFFIEPTNDTSVFTAVFPPVETKRTVRKDVSQVLCQDCAEPKLKNLRSVTVEDGKKTVLKCEILAGNPAPNVKWYKNGKELTGKNKPKSIKIKKKKQGKISELLIRKSTEGDAGLYTCEAVNSLGKTNTTANLFIINTATSTTPSAKTSSHVTPCNESEKEYCVNHGKCFTLEVTPGNIRRLCRCPPGFTGNRCQNRDPVRVVDHKQAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRERNAAAKGPQHPHPPPENLQLVNHYMPTNPVPAHMTDKEAETSLSTNEFTSPTHPSTAITHSSSQCWSNGKAESVVSDSHAVLMKPSAENCQHGTPSHRGRLNATGGVHQLNDYLKNSREAQGSNRDSPYSERYVSAMTTPTRLSPVGLLSPVTPSSPPSEMSAPLSSLATSVPSMLTSPSGEEERPLLFRTPPILRDKSASTQGRKSGHNLRNSAHYNHGLDIPSPPPSPLHIEEEIDCLEQYKSTSVPSSAPHSPSAARTQPSGQAAPEQAVSGSNSESSSSESETEDERVGEDTPFLGLQNPLAAGSLVLDGLEGSRTNPALHLSPQHELQNRLTAVMANQDPIAV
Protein: Rapid alkalinization factor 23 (AtRALF23) (Protein RALF-like 23) (Q9LUS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity). Regulates negatively brassinolide (BL)-mediated signaling pathway (e.g. BL-induced hypocotyl elongation and branching limitation).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- GPI-anchored protein LLG2
- Receptor-like protein kinase FERONIA
- GPI-anchored protein LLG1
- Receptor-like protein kinase THESEUS 1
- Receptor-like protein kinase ANXUR1
- Subtilisin-like protease SBT6.1
- GPI-anchored protein LORELEI
- Receptor-like protein kinase ANXUR2
- Ferritin-4, chloroplastic
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
Sequence:
MRGLSRNSGAAAIFAILLILAVHNWSVAVSSQSTEFAGDFPPFETECRGTIAECSVSAALGDGGDLFYGGGEMGEEFEMDSEINRRILATRRYISYGALRRNTIPCSRRGASYYNCRRGAQANPYSRGCSAITRCRRS
Protein: Transcription factor YY1 (Transcriptional repressor protein YY1a) (YY1 transcription factor a) (Yy1a protein) (Q7T1S3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone deacetylase 1
- Histone-lysine N-methyltransferase EZH2
- RING1 and YY1-binding protein A
- Lethal
- RuvB-like 1
- INO80 complex ATPase subunit.
- Actin-related protein 8
- Actin-related protein 5
- INO80 complex subunit C
- Nuclear factor-related to kappaB-binding protein.
Sequence:
MASGETLYIEADGSEMPAEIVELHEIEVETIETTVVGGDDDEHQPMIALQPLVTDDPNHVNHQEVILVQTREEVVGCDDSDLHADDSFEDQILIPVPVPVAEEEYIEQTLVTVSGKNPSGRMKKGGGSGKRVVKKSFLNSAEASGRKWEQKQVQIKTLEGEFSVTMWASDDKKDVDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDSPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ
Protein: Coiled-coil domain-containing protein 22 (Q9JIG7)
Organism: Mus musculus (Mouse)
Function: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.
Subcellular location: Endosome {ECO:0000250|UniProtKB:O60826}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O60826}.
Interaction partners:
- Coiled-coil domain-containing protein 93
- COMM domain-containing protein 1
- COMM domain-containing protein 8
- COMM domain-containing protein 2
- COMM domain-containing protein 1
- COMM domain-containing protein 4
- Vacuolar protein sorting-associated protein 26C
- COMM domain-containing protein 10
- COMM domain-containing protein 3
- COMM domain-containing protein 6
Sequence:
MEEADRILIHSLRQAGTAVPPEVQTLRAFTTELVVEAVVRCLRVINPDVGSGLSHLLPPAMSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPSDASEDADQPAGDSAIFLRAIGSQIRDQLALPWVPPLLRTPKVQRLQGSALQQPFHSSRLVLPELNSSGELWEFQASPLLLPAPTQVPQLQGRAASLLEHHASQLCQHVNRDCPGDEDRVRWASRVPSQEDSRAPQQRLHKQLIEHLRQSWGPLGAPTQVRDLGEMLQTWGARAMTGVPKGSRFTHSEKFTFHLEPQVQAAQVADVPATSQRLEQDTRAAQEQELESLREQLASVNHNIEEVEADMKTLGINLVQVETECRQSELSVAEQEQALRLKSRTVELLPDGAANLAKLQLVVESSAQRLIHLASQWEKHRVPLLAEYRHLRRLQDCRELESSRRLAEIQELHHSVRAAAEEARRKEEVYKQLVSELETLPKDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETEMGKKTLSNLEKICEDYRALRQENAGLLGRVREA
Protein: Primase-associated factor LEF-2 (P41418)
Organism: Autographa californica nuclear polyhedrosis virus (AcMNPV)
Function: Plays an essential role in viral DNA replication. Does not seem to participate in the initiation step but is rather important for the amplification of DNA. Also required for expression from the vp39 and polh promoters.
Subcellular location: Virion {ECO:0000269|PubMed:20219928}. Host nucleus {ECO:0000269|PubMed:20219928}. Host cytoplasm {ECO:0000269|PubMed:20219928}. Note=Colocalizes with the active viral DNA replication sites in the nucleus of infected cells. {ECO:0000269|PubMed:9060674}.
Interaction partners:
Sequence:
MANASYNVWSPLIRASCLDKKATYLIDPDDFIDKLTLTPYTVFYNGGVLVKISGLRLYMLLTAPPTINEIKNSNFKKRSKRNICMKECVEGKKNVVDMLNNKINMPPCIKKILNDLKENNVPRGGMYRKRFILNCYIANVVSCAKCENRCLIKALTHFYNHDSKCVGEVMHLLIKSQDVYKPPNCQKMKTVDKLCPFAGNCKGLNPICNY
Protein: Cytokine receptor-like factor 2 (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor) (Type I cytokine receptor delta 1) (Q8CII9)
Organism: Mus musculus (Mouse)
Function: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Interaction partners:
- Thymic stromal lymphopoietin
- Interleukin-7 receptor subunit alpha
- Tyrosine-protein kinase JAK2
- Interleukin-33
- Interleukin-7
- Interleukin-4
- Interleukin-13
- Interleukin-5
- Tyrosine-protein kinase JAK3
- Interleukin-9
Sequence:
MAWALAVILLPRLLAAAAAAAAVTSRGDVTVVCHDLETVEVTWGSGPDHHGANLSLEFRYGTGALQPCPRYFLSGAGVTSGCILPAARAGLLELALRDGGGAMVFKARQRASAWLKPRPPWNVTLLWTPDGDVTVSWPAHSYLGLDYEVQHRESNDDEDAWQTTSGPCCDLTVGGLDPARCYDFRVRASPRAAHYGLEAQPSEWTAVTRLSGAASAASCTASPAPSPALAPPLLPLGCGLAALLTLSLLLAALRLRRVKDALLPCVPDPSGSFPGLFEKHHGNFQAWIADAQATAPPARTEEEDDLIHPKAKRVEPEDGTSLCTVPRPPSFEPRGPGGGAMVSVGGATFMVGDSGYMTL
Protein: E3 ubiquitin-protein ligase hel2 (EC 2.3.2.27) (Histone E3 ligase 2) (RING-type E3 ubiquitin transferase hel2) (Q76PD2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ribosome assembly protein 4
- Upstream activation factor subunit spp27
Sequence:
MSPSGPNLNNKEHNRASEKKNSRTHNKKTNRNQSKEKPVSSRSVETPKNAVCLEPVGTDPVSNVATVDASKEEQDEDEQICFICAEGITYSCVLPCNHRMCHVCALRLRALYKTKECTFCKTEWDTVLITKDHEIDIHDVDLAKLPFQDEKLGIVYSDEHAQEESNLLLQFNCPEDACDITCKGWFDLKLHAKVKHHKFFCDLCVKNKKVFTHEHTLFSKKGLTKHNEVGDQGSDLEITGFKGHPKCEFCNTHFYDDDELFKHCREKHERCYICDQVAGRPTHQYFKNYDSLERHFEKDHYICRERECLERKFVVFGTEIDLKAHQLDEHPHNFTQRELREARRIIPQFSYDPPGASGRNRRERTSSTPSEQSTSVNETANSLSNLHLSRGEIAHLRQEEYVREQQARHRDFGFTLSNPAPTSARPATSTRTISRGKTRTLRNEDFPSLAEVANQNSSSAPSVPVSAPRLSGKSASRNHVPSPPKGTKSPMASSEQAQHQQVIDRMQKLTNYDDHKINDFKFAVSSFRGNVMPAREAVARITKLVAKPHEQLSGVFNQIANLLENKEKSRELLEAWQEWKILNAKDDTRIGTTNSNLLRLKRSNRTAAQTASVWNRIERAAAHDGPSLSAPSSSINLANITSRPTNSSAANTPSWGVRKARASALNARSEEDFPALPPSTSKRISVQLGKKQARPVDSWGSTPNTSSNRNSNTMGVSKKKNGKKQTVLFHIG
Protein: Calnexin-independence factor 1 (O59792)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Induces a stably inheritable state of calnexin independence called the Cin state when overexpressed.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:19351719}.
Interaction partners:
- Calnexin homolog
Sequence:
MSEEIITESIVKNFGSAETSVGEKQPKRKRSEVRAEKLKARKLQKAAEIVQKQKENRKILKDVSLKRLSKSLDRSLPSENTIDQISFNHAMSEEDASGYQIGDKHKNLLLYKLSSSSGSVFTENLYSTIQEFLSAQKVDIADSKNTYVFGSTFDKKSHALVKTSDSVRSLKYGSFVKACAPLFRFASGIIKAHAPHFHQALLKLELAPSALRFGVFPNFSLQSVSNGYMSMESNFSSIKYGFVVIIIVGELNDVELKIPAISHSLKLKDGSILVLRSSLLHQWYSLPKQSILYEIRLFAMSSLWHYEKNKSIKIAKKDDI
Protein: Proteasome regulatory non-ATP-ase subunit 9 (Q387U2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proteasome subunit beta
- Ubiquitin carboxyl-terminal hydrolase
- Proteasome regulatory ATPase subunit 6
- Proteasome regulatory non-ATP-ase subunit 10
- Proteasome regulatory non-ATP-ase subunit 2
- Proteasome regulatory non-ATPase subunit 8
- Protease regulatory ATPase subunit 4
- Proteasome regulatory ATPase subunit 3
- Proteasome subunit beta
- Proteasome regulatory ATPase subunit 5
Sequence:
MEERTLQYLDGIIITLRQAGSYGTAEILERAREELAGAQWCEMTDSLLQAVHDPIVLKSAYELHENVLRTVRMEMSPVAYVKLLHTVCFSPNVSLQMALELVDNAVTSLSINPSEQGGNAARCIRALLLLDRQNGCDHIIPLEAAAQEAHNILDSVENFIHSKQMHEVDPVLTALHCQARGKDYKMRRQYTQYYKNAFETVKSAERAEMAILESDMMTLAYDTAIAALLSEEIHNFGKFLNYQCFTERLAASAEHLWILEWLRICNDGKVEEFEQYAETHRSHIESNPVLTRALASVVHKVRLMALLHLVFYTPFNERTFAFDLIARRCAVPLKRVEPLLLAALAQGIIIGKIDGLSEEVHITWVEPRVLSLQEVKELAEHVSHWKKKVMALSQSVMEITQQTPN
Protein: Small ribosomal subunit protein uS7cz/uS7cy (30S ribosomal protein S7, chloroplastic) (P61841)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS12cz/uS12cy
- Large ribosomal subunit protein uL2cz/uL2cy
- Small ribosomal subunit protein uS8c
- Large ribosomal subunit protein uL16c
- Small ribosomal subunit protein uS14c
- Small ribosomal subunit protein uS9c
- Ribosomal protein S12
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS14m
- Large ribosomal subunit protein uL14c
Sequence:
MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRALKKIQQKTETNPLSVLRQAIRGVTPDIAVKARRVGGSTHQVPIEIGSTQGKALAIRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
Protein: Protein ARK2N (ARKadia-like protein 1) (Arkadia (RNF111) N-terminal like PKA signaling regulator protein 2N) (Q96B23)
Organism: Homo sapiens (Human)
Function: AMPK substrate important for exercise capacity and skeletal muscle function. Required for normal contraction-induced signaling.
Subcellular location: Nucleus {ECO:0000269|PubMed:31341047}.
Interaction partners:
- Small ubiquitin-related modifier 1
Sequence:
MKMEEAVGKVEELIESEAPPKASEQETAKEEDGSVELESQVQKDGVADSTVISSMPCLLMELRRDSSESQLASTESDKPTTGRVYESDSSNHCMLSPSSSGHLADSDTLSSAEENEPSQAETAVEGDPSGVSGATVGRKSRRSRSESETSTMAAKKNRQSSDKQNGRVAKVKGHRSQKHKERIRLLRQKREAAARKKYNLLQDSSTSDSDLTCDSSTSSSDDDEEVSGSSKTITAEIPDGPPVVAHYDMSDTNSDPEVVNVDNLLAAAVVQEHSNSVGGQDTGATWRTSGLLEELNAEAGHLDPGFLASDKTSAGNAPLNEEINIASSDSEVEIVGVQEHARCVHPRGGVIQSVSSWKHGSGTQYVSTRQTQSWTAVTPQQTWASPAEVVDLTLDEDSRRKYLL
Protein: Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2-containing protein 5) (O54928)
Organism: Mus musculus (Mouse)
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Interaction partners:
- Tyrosine-protein kinase JAK2
- Interleukin-4 receptor subunit alpha
- Elongin-C
- Cullin-5
- Non-receptor tyrosine-protein kinase TYK2
- Signal transducer and activator of transcription 3
- Elongin-B
- Suppressor of cytokine signaling 3
- Signal transducer and activator of transcription
- Signal transducer and activator of transcription 1
Sequence:
MDKVGKMWNNLKYRCQNLFSHEGGSRNENVEMNPNRCPSVKEKSISLGEAAPQQESSPLRENVALQLGLSPSKTFSRRNQNCAAEIPQVVEISIEKDSDSGATPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDTEKKFGRTRSGLQRRERRYGVSSMQDMDSVSSRAVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDGSAIPQTNCDSEEDSTTLCLQSRRQKQRQVSGDSHAHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
Protein: ferredoxin--NADP(+) reductase (EC 1.18.1.2) (Q41736)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
VAVGASKVLCMSVQQASRSKVSVAPLHLESAKEPPLNTYKPKEPFTATIVSVESLVGPKAPGETCHIVIDHGGNVPYWEGQSYGVIPPGENPKKPGAPQNVRLYSIASTRYGDNFDGRTGSLCVRRAVYYDPETGKEDPSKNGVCSNFLCNSKPGDKIQLTGPSGKIMLLPEEDPNATHIMIATGTGVAPFRGYLRRMFMEDVPNYRFGGLAWLFLGVANSDSLLYDEEFTSYLKQYPDNFRYDKALSREQKNRSGGKMYVQDKIEEYSDEIFKLLDGGAHIYFCGLKGMMPGIQDTLKKVAERRGESWDQKLAQLKKNKQWHVEVY
Protein: Nebulin-related-anchoring protein (N-RAP) (Q80XB4)
Organism: Mus musculus (Mouse)
Function: May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.
Subcellular location: Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. {ECO:0000269|PubMed:11732910, ECO:0000269|PubMed:15765519, ECO:0000269|PubMed:9295142}.
Interaction partners:
- Xin actin-binding repeat-containing protein 1
- Kelch-like protein 41
- Tripartite motif-containing protein 54
- Myotilin
- Telethonin
- Titin
- Alpha-actinin-3
- Leiomodin-3
- Myomesin 2
- Leiomodin-2
Sequence:
MNVQACSRCGYGVYPAEKISCIDQTWHKACFHCEVCKMMLSVNNFVSHQKKPYCHAHNPKNNTFTSVYHTPLNLTLKKSVAAMGGIDGKEDGEPFKSVLHWDMKSKAGAGAASRLMNERDYWPGYAEGNTWCPGALPDPEIVRMVEARQSLGEGYTEDREQQQGKGSFPAMITPAYQRAKAANQLASQVQYKRGHDERVSTFTPVADTPELLRAKAGGQLQNDVRYTEDGGQQRGKGSFPAMITPAYQIAKRATELASDVRYHQQYHREMKGMASPVGAEGGMTKDSVDRCGQVYSEECDEPRGKGSFPAMITPAYQNAKKANELVSDIKYRQDFHKMKGAAHFHSLAAQDNLVLKRAQSVSKLVSEVEYKKGLENSKGHSINYCETPQFRNVSKISKFTSDNKYKENYQTQLRGHYDGVGMDRRMLHALKVGSLASNVAYKADYKHDVVDYNYLATATPFYQTTMRLVPLKDVNYRQNIDRMKFSSVTNTPQIVQAKINAQQLSHVNYRADYERNKLNYTLPQDAPQLLKAKANAELFSEVKYKEGWQKTKGKGFEMKLDAMSLLAAKASGELASSVKYKEEYEKMKGRALGATDSKLLHSLQVAKMSSEVEYKKGFEESKTHFNLPMDMVNLRHAKKAQALASDLDYRKKLHDYTVLPEDMKTQWAKKAYGLQSELQYKADLAWMRGVGWLTEGSLNLEQAKKAGQLISEKNYRQRVDELKFTSVADSSQMEHAKKSQGLQNAVAYKAGNEQSVHQYTISKDEPLFLRARANAAQLSETLYKSSWEKQKAKGFELRLDSLAFLTAKAKRDLASEVKYKEDYERSRGKLIGAKSAQGDSQMSHSLQMSKLQSDLEYKKGFEDTRSQCHISLDMVHLVHARQAQHLATDVGYRTASHCFTALPTDMKVEWAKKAYGLQSDNQYRADMKWMKGTGWVATGSLHVEQAKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGENVKHHYTQTADLPEVLLAKLNAMNISETRYKESWSRLRDGGYKLRLDALPFQAAKASSEVISDYKYKEAFERMKGQMLGSRSLEDDLSLAHSVHATSLQSDVNYKKGFEHAKAHFHLPLDMVTLVHAKKAQTLASDQDYRHPLPQHTVLAEDLRLSCAKKAHKLQSENLYRSDLNFMRGVPCVVPGTLEIEGRKKASELISESKYRQHPGSFKYTAVTDTPNLLHAKYSNQITNERLYKAAGEDARHQYTMTLGLPEFIRAKTNAANLSEAKYKEAWHNLRAQGYKLTIDALPFQAARASGDIASDFLYRHEFVKERGQLIGVRNVSDDPRLLHCLRMGQLQSENQYRKEAASSQAQCHLPMDMMYLVHARKAQALASDHDYRTQCHEFTALPEDLKMAWAKKAHALQSEFRYKADLMGMKGTGWLALQSPQIESAKKAGDLISETKYRKKPDSIKFTTVVDSPDLIHAKESYMHCNERLYRLGDAASLHRYTPIPDHPDFTRARMNAMHLSDKVYRNAWEQSRAGGYDFRLDAIPFQTARVSRDIASDFRYKEAFLRDRGLQIGYRSISDDPRTTHFLRVGRLQSDNEYRKAFAKGRSQFHSRADQPGFLQAKRSQQLASDVLYRQPLPQHTSDPEQLGLKHARKAHQLQSDVKYKSDLNLTRGVGWTPPGSYKVEMARRAAELANRRGPGIRGASVEPEAAAALGDHQSRGVNPDASEILHIHKKKTLLM
Protein: Magnetosome protein MamZ (Probable magnetosome permease MamZ) (Q2W8K5)
Organism: Paramagnetospirillum magneticum (strain ATCC 700264 / AMB-1) (Magnetospirillum magneticum)
Function: Required for correct biomineralization of the magnetosome; probably converts and then transports some form of iron. It is partially functionally redundant with MamH. May function with MamX, MamY amd Mms6.
Subcellular location: Magnetosome membrane {ECO:0000269|PubMed:27481925}; Multi-pass membrane protein {ECO:0000255}. Note=Tagged protein forms straight lines with a punctate pattern extending along most of the cell associated with its inner curvature, in the correct position to be associated with magnetosomes, but longer than the usual chain. {ECO:0000269|PubMed:27481925}.
Interaction partners:
- Protein-methionine-sulfoxide reductase catalytic subunit MsrP
- Magnetosome protein MamX
- Cell division protein FtsZ
- Liposome tubulation protein MamY
- Sulfite oxidase and related enzyme
Sequence:
MPRNAEAPAKGTTADDFAPTQWNIIYLLMTVGALMAALSISIQPLLLDKIFGIAFEKEGAVNADIQVVAEIVSIVCVGWFGLLSDRIGRVRIIALGFLIAVVGAAVSLLSLQVGLAFGAAGLVLFYLTRVLLTVGADTVQLQLSTLVGDVSSRANRPRLMGNLVFMMVFGGTMLAAIVMQMADYPGGVFLIMCLPLLAGIAGFQLTRRNLRDVAPPQPASEDDEHPLRQVWTVITSDPRMQLAFAAAFYTRADVIILSLFFSLWCISVSDLVGVTRTFATAHAAVMIGLLGLAVLAAVPLWRSFIERHSRISAIGASLSLAALGYIWLGMFANPFNWLVALPLLMVGIGHAGCFVTLQVLTVDASPKPILGAMVGAGYLVGGLGTVMLVQSGGYYFDALGPRAPFILMGTGKMLVTLYAAWLLANGIDETCDHHLKSARTVDWKPLVFLTAALPFVWLVGRSVIEGYISNGSLGEAPVGFVNRYLGDWAFTFLIISLAMRPVQEITGIKTLAKYRRMIGLFAFFYAVMHVLAYVALEWALNLGDMMGDIYKRPFILLGLVAFALLIPLAFTSANSQIKRIGGKRWKKLHSATYVINALVALHFILAANHENGEPYVYAAAVIVLLWYRFHQWRGGNVLRALRIG
Protein: eIF4G1 protein (B2RU06)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQGGFRSLQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASVAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Protein: Bifunctional enolase 2/transcriptional activator (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase 2) (2-phosphoglycerate dehydratase 2) (LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1) (P25696)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Multifunctional enzyme that acts as an enolase involved in the metabolism and as a positive regulator of cold-responsive gene transcription. Binds to the cis-element the gene promoter of STZ/ZAT10, a zinc finger transcriptional repressor.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12032082, ECO:0000269|PubMed:12953116}. Nucleus {ECO:0000269|PubMed:12032082}. Mitochondrion outer membrane {ECO:0000269|PubMed:12953116}. Note=Found in circular or rod-shaped bodies that colocalizes with mitochondrion marker. {ECO:0000269|PubMed:12953116}.
Interaction partners:
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1
- Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2
- Phosphoglycerate kinase 3, cytosolic
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1
- Phosphoglycerate mutase-like protein 4
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2
- Phosphoglycerate kinase 1, chloroplastic
- Glucose-6-phosphate isomerase 1, chloroplastic
- Pyruvate kinase
- Triosephosphate isomerase, cytosolic
Sequence:
MATITVVKARQIFDSRGNPTVEVDIHTSNGIKVTAAVPSGASTGIYEALELRDGGSDYLGKGVSKAVGNVNNIIGPALIGKDPTQQTAIDNFMVHELDGTQNEWGWCKQKLGANAILAVSLAVCKAGAVVSGIPLYKHIANLAGNPKIVLPVPAFNVINGGSHAGNKLAMQEFMILPVGAASFKEAMKMGVEVYHHLKSVIKKKYGQDATNVGDEGGFAPNIQENKEGLELLKTAIEKAGYTGKVVIGMDVAASEFYSEDKTYDLNFKEENNNGSQKISGDALKDLYKSFVAEYPIVSIEDPFDQDDWEHYAKMTTECGTEVQIVGDDLLVTNPKRVAKAIAEKSCNALLLKVNQIGSVTESIEAVKMSKKAGWGVMTSHRSGETEDTFIADLAVGLSTGQIKTGAPCRSERLAKYNQLLRIEEELGSEAIYAGVNFRKPVEPY