wanglab/gogpt-training-data huggingface dataset:
Protein: SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes) (Q925Q9)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration (By similarity). Has an essential role in the stimulation of B cell activation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96B97}. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse, synaptosome. Cell junction, focal adhesion. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions. Colocalized with MAGI2 in synaptosomes. Colocalizes with ZFP36 in the cytoplasm (By similarity). Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). {ECO:0000250|UniProtKB:Q8R550, ECO:0000250|UniProtKB:Q96B97}.
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- E3 ubiquitin-protein ligase CBL-B
- Receptor protein-tyrosine kinase
- B-cell linker protein
- Disabled homolog 1
- E3 ubiquitin-protein ligase CBL-C
- Polyubiquitin-C
- SOS Ras/Rac guanine nucleotide exchange factor 1
- Growth factor receptor-bound protein 2
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MVEAIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKDVKKDLLSNKAPEKPMHDVSSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGFLPASLLPFPAHGAKGKTTFEGTILYRAAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPATSTPDPSKTEMDSRTKTKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPSDFDKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPETLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLNRPGVLPPRRPERPVGPLTHTRGDSSKIDLAGSTLSGILDKDLSDRSNDIDLEGFDSVISSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGIDVSKKTSRTVTISQVSDNKASLPPKPGTMAAASSGPASLSSVASSPMSSSLGTAGQRASSPSLFSAEGKAKTESAVSSQAAIEELKMQVRELRTIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
Protein: Smr (Small MutS Related) domain-containing protein (Q9LT11)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable DNA helicase MCM9
- Replication protein A 70 kDa DNA-binding subunit B
- Origin of replication complex subunit 1A
- Nucleosome assembly protein 1;2
Sequence:
MSWMKGKSSGWTAFDLKQRQKQGLESEVEGDPFPPVSTSVNASFGVRGRLRRNHEPSEKSFSSVLLPPSRFPALTENKDCGNQERGGCCRRKPDTLSLPVNSHDLAFTKLKEMNSWADDNLIRDVLLSTEDDFEMALAFLKGMVSSGKEDEEPTSKIEGYSSDNRRSEYRTFEKTVTSSVKMAARSTFEDAGKYDLENSDGSSFLVNASDNEKFPDDISELDSIIQRLQSIPIEPEWEEDDLYLSHRKDALKVMRSASNHSRAAQNAFQRYDHASAKQHSDKAREDWLAAEKLNAEAAKKIIGITNKDNDIWKLDLHGLHATEAVQALQERLQMIEGHFTVNRSVSPNRGRSKNAALRSASQEPFGRLDEEGMHCQRTSSRELRNSLQVITGIGKHSRGQASLPLAVKTFFEDNRYRFDETRPGVITVRPKFRHS
Protein: Fumarate reductase iron-sulfur subunit (EC 1.3.5.1) (Quinol-fumarate reductase iron-sulfur subunit) (QFR iron-sulfur subunit) (P0AC47)
Organism: Escherichia coli (strain K12)
Function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used during anaerobic growth, and succinate dehydrogenase is used during aerobic growth. The QFR enzyme complex binds 2 quinones in or near the membrane; 1 near the [3Fe-4S] cluster (QP is proximal to the [3Fe-4S] cluster, on the cytoplasmic side of the membrane) while QD (the distal cluster) is on the other side of the membrane. It is not clear if both of the quinol-binding sites are functionally relevant.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:10373108}; Peripheral membrane protein {ECO:0000305|PubMed:10373108}; Cytoplasmic side {ECO:0000305|PubMed:10373108}.
Interaction partners:
- Fumarate reductase subunit C
- Fumarate reductase flavoprotein subunit
- Succinate dehydrogenase flavoprotein subunit
- Fumarate reductase subunit D
- Succinate dehydrogenase cytochrome b556 subunit
- NADH-quinone oxidoreductase subunit C/D
- Succinate dehydrogenase hydrophobic membrane anchor subunit
- Succinate--CoA ligase subunit beta
- Succinate--CoA ligase subunit alpha
- Probable pyruvate-flavodoxin oxidoreductase
Sequence:
MAEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTADQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR
Protein: Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB) (P14679)
Organism: Homo sapiens (Human)
Function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Subcellular location: Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000250|UniProtKB:P11344}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P11344}.
Interaction partners:
- Melanocyte protein PMEL
- P protein
- Melanoma antigen recognized by T-cells 1
- Microphthalmia-associated transcription factor
- Membrane-associated transporter protein
- Tyrosine 3-monooxygenase
- Aromatic-L-amino-acid decarboxylase
- Melanocyte-stimulating hormone receptor
- L-dopachrome tautomerase
- Thyroid peroxidase
Sequence:
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
Protein: Forkhead box protein N4 (Q8K3Q3)
Organism: Mus musculus (Mouse)
Function: Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:22323600}.
Interaction partners:
- Pancreas transcription factor 1 subunit alpha
- Visual system homeobox 1
- Transcription factor Atoh7
- Visual system homeobox 2
- Neurogenic differentiation factor 4
Sequence:
MIESGIWSRMSEMIRSSGHSHHCSPQEYRFLPPVGDDDLPGDLQSLSWLTAVDVPRLQQMANGRIDLGSSGVTHPHPGALAGTADLHVGAAPRPLLRRSQTAVVPRGVLGLSPIGNHRASAEQMNQFPAGGQASSGLQEMPQLYSPATQIPFPLPLGSQQCPPAGLYGSPFSARPSYPQAHGAMHASQEPHPKHYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVETKSSGSSRKGCLWALNLARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKRGEPKAPMLTHATTVAMAHSCLAISQLPPKPLMTLSLQSVPLHHQLQPQAHLAPDSPAPAQTPPLHALPSLSPGPLPQPAMGRVPGDFLNINSDMNTEVDALDPSIMDFALQGNLWEEMKEDSFSLDTLEAFGDSPLGCDLGAPSLTPVSGNSDQSFPDVQVTGLYAAYSTAADGVAPSAANSAQYLGTPGNKPIALL
Protein: Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) (P35658)
Organism: Homo sapiens (Human)
Function: Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:8108440}. Note=Cytoplasmic side of the nuclear pore complex. {ECO:0000269|PubMed:8108440}.
Interaction partners:
- Nuclear pore glycoprotein p62
- Nuclear pore complex protein Nup88
- Exportin-1
- Nuclear pore complex protein Nup133
- Nuclear pore complex protein Nup98-Nup96
- Nuclear pore complex protein Nup85
- Nuclear pore complex protein Nup107
- E3 SUMO-protein ligase RanBP2
- Nuclear pore complex protein Nup93
- Nuclear pore complex protein Nup205
Sequence:
MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGGWRS
Protein: Protein TITANIA (OsTITANIA) (OsTTA) (Protein LOW CADMIUM 5) (Q10PC5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor that functions as regulator of metal transporter genes responsible for essential metals delivery to shoots and normal plant growth. Required for the maintenance of metal transporter gene expression, such as IRT1, IRT2, ZIP1, ZIP9, NRAMP1 and NRAMP5.
Subcellular location: Nucleus {ECO:0000269|PubMed:30194869}.
Interaction partners:
- Nitrate reductase 1
- Nitrate reductase
- Nitrate reductase
- protein-serine/threonine phosphatase
- Os04g0589400 protein
- Small ribosomal subunit protein uS2c
- Os01g0220300 protein
- Os06g0255200 protein
- Os02g0102400 protein
- Os08g0513300 protein
Sequence:
MFGDSDGSKDANPGAPPSTTDPPFPNRELTLSSYLCEKPTLASAAAGGGGGAGPSSPPNPAAAAAGDDGKHCVERDFLHLSAPKRGDPPGDDSSVVGGKKPRLDSLQLSLSLNSDGPAAPPSSQPPLASLLQPVPATDGDLRGAAAAAAVPAAPARRTYSATTARTRSINSDDMSYSYSIFSHNPSCSLTHNSTDIYAAGEGTNGSVHSRFNFRPMGDGSVAFATPPLKEGTSSFFPTELPARMAAAAAAAAASAGGSFDGGRGGLHASRPDKILRDIVSDSVTAMAQVLQDFPSERLELLREAVRGMIDSHEKRDELASLQRKLERRSDLTTETLGRANRTQLEILVAIKTGIATFVTGKGRVPSSELVEMFLMTRCRNLNCKSTLPVDDCDCKICSTKKGFCSACTCSVCHKFDCAANTCTWVGCDVCGHWCHVACALERNLIRPGPTLKGPIGTTEMQFQCLACNHSSEMFGFVKEVFNCCAENWNAETLMKELDFVRKIFAGCEDFEGKGLHAKAEEVLSLLGKKIISPLDATNSILQFFKYGVTDYSVTGSTSKGILAAQASQSTDMRSLQTPTITPPKSSFNFKTTTSILDTDALKPSPKPLSIEPHFSTASKEDDSSLETIVKCKEAEAKLFQKLADDARKEVDSYRQIVRSRTQKLEEEYAAKLAKVCFQETEEKRRKKLEELKMLENSHYDYLKMKMRMQTDIQGLLERMEATKKMWV
Protein: Evasin-1 (EVA1) (P0C8E7)
Organism: Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Function: Salivary chemokine-binding protein which shows chemokine neutralizing activity and binds to host chemokines CCL3, CCL4 and CCL18. Binds to CCL3 with 1:1 stoichiometry.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MTFKACIAIITALCAMQVICEDDEDYGDLGGCPFLVAENKTGYPTIVACKQDCNGTTETAPNGTRCFSIGDEGLRRMTANLPYDCPLGQCSNGDCIPKETYEVCYRRNWRDKKN
Protein: ATP-dependent zinc metalloprotease FTSH 1 (EC 3.4.24.-) (Q8I526)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Prohibitin
- ATP-dependent protease subunit ClpQ
- Prohibitin
Sequence:
MSSKYDNQSFLSTGSDKYGEQENSVLLHDEEDEYINENKKKRNERDKKFRYYENFFNRRRSKKWNYFIIFFLGVCLGFAIWPFFMTIITYRLFYKDNFNNTNYRTNNSSTSLKSYGNEKNKKSDNNGKVPMKDQSPNKVSPHFKPIRFEEIAGIDESKLELLEVVDFIKNREKYHEMGARMPKGVLLVGPPGSGKTMLARAVATEANVPYIYTSGPEFIEIYVGQGAKRIRQLFAHARSVAPSIVFIDEIDAIGGKRSSGSVNGAGQREHDQTLNQLLVEMDGFSNTVHIMVIGATNRIDTLDSALLRPGRFDRIVYVPLPDINGRKKILEIYIKKIKSDLKLEDIEKIARLTPGFSGADLENVVNEATILATRNNKSLVTINELYEARDKVSMGPERKSLRQSDHQRRITAYHEAGHAIVAYFLQPKTDPIHKATIISRGNALGYVEQIPVDDRHNYFKSQMEAKLAVCMGGRTAEEIVFGKSETSSGASSDISRATEIAYKMVTEWGMSDKLGPLNYKKRMGDGYSSNRLSAQTVSSIEVEVKSLVEKGKSLSEEILRRHRKELDNLAFALLDKETLSGEEIKNIIDPNNSKNYSGKVEMLKNDTKKNEKKSNSVSKNKSTISEDYDKNQNNVEQNYQSHDHTLVKNEENLNNMKNDIDDNNTRDGQVNSDSFVKRKEVTDQDINGKELSEMDNKEIKENKKLDGEELNKIIIDNDKMGDMKKNIKEVIKKMKKKQSKGSYKTYKNVLKSVSEHKELKTQKKADENKIVADNNEKSSNNSLDKNNTQGSIDEKGYKNNNNNNNNMVKNINELFEENFPEYKKYDNENNDFVKTKENYFDNFNEVIDISHIKNVDEMKKFNIFEHNLNKLFLFDIFKSD
Protein: Protein TOS4 (Target of SBF protein 4) (Q06266)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds to the promoters of genes with functions important for the G1/S (start) transition; primarily genes involved in pheromone response, polarized growth and transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:15282802}.
Interaction partners:
- Probable histone deacetylase HOS2
- Histone deacetylase RPD3
- Transcriptional regulatory protein ASH1
- SET domain-containing protein 3
- Cyclin-dependent kinase 1
- Transcriptional regulatory protein DOT6
- Transcriptional regulatory protein UME1
- Transcriptional regulatory protein UME6
- Transcriptional regulatory protein SIN3
- Transcriptional regulatory protein PHO23
Sequence:
MSSQFPSSPYRTVDPYSPPNYKQQPNCPSSNYEKAGKTASESIGNFGKGDYPTPFPSSSIGRVSSPVRSNKVDAIPSSPAFPGQLAETSPKFSSKLSSPSRHTRVINAELDPSKISTITVGRNSSQCDVALCKNKFISRVHASITYLPQTNEVKIHCFSMNGLIVTYRKQFDCYQLKDTMNNNNRAYRLVPRFSNEKCVKEIQDEGGFINFTLEEGDTVYMTYYKGIMLDFRQVLLRISLKEKNSSSEPLRFEKKAEFESESETKHMGSIRKHPLIFTDTSMDRPKKILKDSNKISIGSDSGVAERMLNHFLNSKSSPLSSVSSVDHEEQTLRQDSLSSDKNPMTMKKPKLNKRVLPSKPKKSVKENLDELSRRNIDVMHLQHILTNHLAFANVQQTPLFQLQQVNSQISELSRDELRSILSDAKCVGVIYRHGKDAAGKPLDEEYFYDLENDDDYERRNLVSSLKGGRTGLRSCRRTHKQYFWKKPAK
Protein: LIM domain containing 2 (J3QQM5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFQAAGAAQATPSHDAKGGGSSTVQRSKSFSLRAQVKETCAACQKTVYPMERLVADKLIFHNSCFCCKHCHTKLSLGSYAALHGEFYCKPHFQQLFKSKGNYDEGFGRK
Protein: Translocon at the outer membrane of chloroplasts 64 (Q9MUK5)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Chaperone receptor mediating Hsp90-dependent protein targeting to chloroplasts. Bi-functional preprotein receptor acting on both sides of the membrane.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MKSMASPSSQIWVILGLGLAGIYVLTRKLTQAVKEDFGAFLLKLKLLPPPPPAPPKAPHPLSSLNFAISDIFDIEGHVSTFGHPEWARTHEPASSTASAVSALVESGATCIGTTVVDELAYGISGENKHFGTPTNPAVPNRVPGGSSSGAAVAVAANFVDFSLGVDTSGGVRVPAGFCGILGFRPSHGAVSHVGIIPVSTSLDTVGWFAKDPDVLRRVGHILLQAPFVMQRNPRQIIIADDCFQHLNVPLDRTSQVVIKATEKLFGKQVLKHINFEDYISSKVSSLKACSIQKSNGVLKSSSLKLLANVMQSLQRHEFEHTHSEWMSIVKPDLHPAVSAQLHEKFEVSELEIENSKSVRSELRVAVNSLLKDEGVLVIPTVADPPPKLGGKEFLSHDYQSRALSLLSIASISGCCQVTVPLGFFDKNPVSVSLIARHGGDRFLLDTLKTMYTVLQEQADIAAPSKSSKSVVSKEQSAEISKEKGNQAYKDKQWQKAIGFYTEAIKLCGNNATYYSNRAQAYLELGSYLQAEEDCTTAISFDKKNVKAYFRRGTAREMLGYYKEAIDDFKYALVLEPTNKRAASSAERLRKLFQ
Protein: Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome) (P79739)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers. May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein. Microsome membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein.
Interaction partners:
- Aldehyde dehydrogenase 1 family, member A2
- Retinol dehydrogenase 10-B
- Aldehyde dehydrogenase 1 family member A3
- Short-chain dehydrogenase/reductase 3
- Retinol dehydrogenase 10-A
- Retinol dehydrogenase 20
- Arginyl-tRNA synthetase
- Dehydrogenase/reductase
- Epidermal retinol dehydrogenase 2
- All-trans-retinol 13,14-reductase
Sequence:
MGLYTLMVTFLCTIVLPVLLFLAAVKLWEMLMIRRVDPNCRSPLPPGTMGLPFIGETLQLILQRRKFLRMKRQKYGCIYKTHLFGNPTVRVMGADNVRQILLGEHKLVSVQWPASVRTILGSDTLSNVHGVQHKNKKKAIMRAFSRDALEHYIPVIQQEVKSAIQEWLQKDSCVLVYPEMKKLMFRIAMRILLGFEPEQIKTDEQELVEAFEEMIKNLFSLPIDVPFSGLYRGLRARNFIHSKIEENIRKKIQDDDNENEQKYKDALQLLIENSRRSDEPFSLQAMKEAATELLFGGHETTASTATSLVMFLGLNTEVVQKVREEVQEKVEMGMYTPGKGLSMELLDQLKYTGCVIKETLRINPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADVFPNKEEFQPERFMSKGLEDGSRFNYIPFGGGSRMCVGKEFAKVLLKIFLVELTQHCNWILSNGPPTMKTGPTIYPVDNLPTKFTSYVRN
Protein: Pentalenene synthase (PS) (EC 4.2.3.7) (Pentalenolactone biosynthesis protein A) (Sesquiterpene cyclase) (Sesquiterpene synthase) (Q82IY4)
Organism: Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Function: Catalyzes the cyclization of farnesyl diphosphate (FPP) to the tricyclic sesquiterpene pentalenene in the biosynthesis of neopentalenolactone antibiotic.
Interaction partners:
Sequence:
MPQDVDFHIPFPSRRSPDFERARADHLSWPRALGLIGTDAAAERHSRGGYADLAARFYPSATGADLDLGVDLMSWFFLFDDLFDGPRGEDPQETRKLTDAVAAALDGPLPTSAPPIAHGFADVWRRTCQGMSPAWRARSARHWRNYFSGYVDEAVSRHLNTPYDSAGHYLAMRRQTIGVQPTVDLAERSCHCEVPQRVFDSAVLFAMLQIATDTNLILNDIASLEKEEARGELNNMVFILMREHGWTRGRSIAHMQDGVRTRLEQFLLLEACLPKVYDTFELTAQERESAEKYRMDGVRSVIRGSYDWHRSSGRYAADYAIAASYQGYLEELGSTL
Protein: T-complex protein 1 subunit gamma (Q8JHI7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MMGRPVLVLSQNIKRESGRKVQIGNISAAKTIADIIRTCLGPRAMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEQFLEQQMHPTVVIGAYRQALDDMLNILKDISTPVDVSNRDMMLKIINSAINTKALSRWSTLACNIALDAVRTVELDENGREEIDIKKYAKVEKVPGGIIEDSCVLRGVMVNKDVTHPRMRRLIKNPRIVLLDCSLEYKKGESQTDIEIAREEDFARILQMEEEYVQQICEDIIRLKPDLIFTEKGISDLAQHYLMKANITAIRRIRKTDNNRIARACGARIASRTDELTENDVGTGTGLFEVKKIGDEYFTFVTECKDPKACTILLRGASKEILAEVERNLQDAMQVCRNVLLDPYLLPGGGAVEMEVSHRLTERSRAMTGVEQWPYRAVAQALEVVPRTLIQNCGASAIRVLTSLRAKHTQEGNSSWGVNGETGTLADMEQLGIWEPLAVKAQTYKTAVETAILLLRIDDIVSGHKKKGDGEQTGGAPMEDRE
Protein: 10 kDa chaperonin 1, chloroplastic (Q9M1C2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as co-chaperone for protein folding in chloroplasts.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Chaperonin 60 subunit beta 3, chloroplastic
- Chaperonin 60 subunit beta 2, chloroplastic
- Chaperonin 60 subunit beta 1, chloroplastic
- Chaperonin 60 subunit alpha 2, chloroplastic
- Chaperonin 60 subunit alpha 1, chloroplastic
- Chaperonin 60 subunit beta 4, chloroplastic
- Chaperonin CPN60, mitochondrial
- Protein groES
- ATP-dependent Clp protease proteolytic subunit 6, chloroplastic
- ATP-dependent Clp protease ATP-binding subunit CLPT2
Sequence:
MASSFITVPKPFLSFPIKTNAPTLPQQTLLGIRRNSFRINAVSTKWEPAKVVPQADRVLVRLEVLPEKSSGGVLLPKSAVKFERYLTGEVVSVGSEVGEVEPGKKVLFSDMSAYEVDFGTEDAKHCFCKESDLLAIVQ
Protein: Transcriptional regulator YqjI (P64588)
Organism: Escherichia coli (strain K12)
Function: Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression.
Interaction partners:
- NADPH-dependent ferric-chelate reductase
Sequence:
MSHHHEGCCKHEGQPRHEGCCKGEKSEHEHCGHGHQHEHGQCCGGRHGRGGGRRQRFFGHGELRLVILDILSRDDSHGYELIKAIENLTQGNYTPSPGVIYPTLDFLQEQSLITIREEEGGKKQIALTEQGAQWLEENREQVEMIEERIKARCVGAALRQNPQMKRALDNFKAVLDLRVNQSDISDAQIKKIIAVIDRAAFDITQLD
Protein: Protein TIC 22, chloroplastic (Translocon at the inner envelope membrane of chloroplasts 22) (AtTIC22) (Q9SZB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in protein precursor import into chloroplasts. Imported into the intermembrane space via the Toc translocon. May be involved in the import pathway used by proteins without a cleavable N-terminal pre-sequence (By similarity).
Subcellular location: Plastid, chloroplast intermembrane space {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Protein TIC110, chloroplastic
- Protein TIC 40, chloroplastic
- Protein TIC 55, chloroplastic
- Protein TOC75-3, chloroplastic
- Protein TIC 62, chloroplastic
- Short-chain dehydrogenase TIC 32, chloroplastic
- Protein TIC 21, chloroplastic
- Translocase of chloroplast 159, chloroplastic
- Translocase of chloroplast 34, chloroplastic
- Protein TIC 100
Sequence:
MESSVKPNPFLSFSSFIHHQCTRFSSDLSARIEDTKRFAETLATRRFSLPTPPPFASVSQSKSGTPTTTLSPSLVAKALAGTSVFTVSNTNNEFVLISDPTGGKSIGLLCFRQEDAEAFLAQARLRRRELKTNAKVVPITLDQVYLLKVEGISFRFLPDPIQIKNALELKSSGNKNGFDGVPVFQSELLVVRKKNRRYCPVYFSKEDIERELSKYTRASRGDQQIMVGSLEDVLRKMEMSEKNSGWEDVIFIPPGRSYAQHMQDLIKE