wanglab/gogpt-training-data huggingface dataset:
Protein: Pentatricopeptide repeat-containing protein At5g03800 (Protein EMBRYO DEFECTIVE 175) (Q9FFN1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in embryogenesis.
Interaction partners:
- Pentatricopeptide repeat-containing protein At5g14080
- Uncharacterized protein At4g19900
- Glycosyltransferase-pyrophosphoryl-undecaprenol N-acetylglucosamine transferase)
- At3g57630
- Glycosyltransferase
- At1g19710
- Glycosyltransferase
- dolichyl-phosphate beta-glucosyltransferase
Sequence:
MSTVNHHCLLNFPHIPPSIPPNHRPKLLSSLSLYRKPERLFALSASLSLSPATIHECSSSSSSSSSSFDKEETEDIESVIDGFFYLLRLSAQYHDVEVTKAVHASFLKLREEKTRLGNALISTYLKLGFPREAILVFVSLSSPTVVSYTALISGFSRLNLEIEALKVFFRMRKAGLVQPNEYTFVAILTACVRVSRFSLGIQIHGLIVKSGFLNSVFVSNSLMSLYDKDSGSSCDDVLKLFDEIPQRDVASWNTVVSSLVKEGKSHKAFDLFYEMNRVEGFGVDSFTLSTLLSSCTDSSVLLRGRELHGRAIRIGLMQELSVNNALIGFYSKFWDMKKVESLYEMMMAQDAVTFTEMITAYMSFGMVDSAVEIFANVTEKNTITYNALMAGFCRNGHGLKALKLFTDMLQRGVELTDFSLTSAVDACGLVSEKKVSEQIHGFCIKFGTAFNPCIQTALLDMCTRCERMADAEEMFDQWPSNLDSSKATTSIIGGYARNGLPDKAVSLFHRTLCEQKLFLDEVSLTLILAVCGTLGFREMGYQIHCYALKAGYFSDISLGNSLISMYAKCCDSDDAIKIFNTMREHDVISWNSLISCYILQRNGDEALALWSRMNEKEIKPDIITLTLVISAFRYTESNKLSSCRDLFLSMKTIYDIEPTTEHYTAFVRVLGHWGLLEEAEDTINSMPVQPEVSVLRALLDSCRIHSNTSVAKRVAKLILSTKPETPSEYILKSNIYSASGFWHRSEMIREEMRERGYRKHPAKSWIIHENKIHSFHARDTSHPQEKDIYRGLEILIMECLKVGYEPNTEYVLQEVDEFMKKSFLFHHSAKLAVTYGILSSNTRGKPVRVMKNVMLCGDCHEFFKYISVVVKREIVLRDSSGFHHFVNGKCSCRDLW
Protein: Protein 4.1 (Band 4.1) (Erythrocyte membrane protein band 4.1) (A0A2R8YFR9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGV
Protein: Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) (P41245)
Organism: Mus musculus (Mouse)
Function: Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (By similarity). Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond (By similarity). Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P14780}.
Interaction partners:
- Metalloproteinase inhibitor 1
- Metalloproteinase inhibitor 3
- CD44 antigen
- Metalloproteinase inhibitor 2
- Neutrophil gelatinase-associated lipocalin
- Thrombospondin-1
- Cathepsin G
- Vascular endothelial growth factor A, long form
- Proto-oncogene tyrosine-protein kinase Src
- Syndecan-1
Sequence:
MSPWQPLLLALLAFGCSSAAPYQRQPTFVVFPKDLKTSNLTDTQLAEAYLYRYGYTRAAQMMGEKQSLRPALLMLQKQLSLPQTGELDSQTLKAIRTPRCGVPDVGRFQTFKGLKWDHHNITYWIQNYSEDLPRDMIDDAFARAFAVWGEVAPLTFTRVYGPEADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGAGVQGDAHFDDDELWSLGKGVVIPTYYGNSNGAPCHFPFTFEGRSYSACTTDGRNDGTPWCSTTADYDKDGKFGFCPSERLYTEHGNGEGKPCVFPFIFEGRSYSACTTKGRSDGYRWCATTANYDQDKLYGFCPTRVDATVVGGNSAGELCVFPFVFLGKQYSSCTSDGRRDGRLWCATTSNFDTDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPLYSYLEGFPLNKDDIDGIQYLYGRGSKPDPRPPATTTTEPQPTAPPTMCPTIPPTAYPTVGPTVGPTGAPSPGPTSSPSPGPTGAPSPGPTAPPTAGSSEASTESLSPADNPCNVDVFDAIAEIQGALHFFKDGWYWKFLNHRGSPLQGPFLTARTWPALPATLDSAFEDPQTKRVFFFSGRQMWVYTGKTVLGPRSLDKLGLGPEVTHVSGLLPRRLGKALLFSKGRVWRFDLKSQKVDPQSVIRVDKEFSGVPWNSHDIFQYQDKAYFCHGKFFWRVSFQNEVNKVDHEVNQVDDVGYVTYDLLQCP
Protein: Uncharacterized oxidoreductase C4H3.08 (EC 1.-.-.-) (Q10216)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Putative acyl carrier protein, mitochondrial
- Zinc-type alcohol dehydrogenase-like protein C1773.06c
Sequence:
MDPVPSTQTQKWPGKHADLDPEPSLLRYCDGRVHVGSGKLAEKKTLLTGGDSGIGKAAAVMFAREGSDLVISCLPEERDDAEVTRDLIEREGRNCWIWEGKLDKSDNCRDLVDFALKKLGWIDVLVNNIAYQQVAQSIEDIDDEQWDLTFKTNIFSFFWVTKAAISHMKSGSSIVNCSSINAYVGRPDLLDYTSTKGAITAFTRGLSNQYAQHGIRVNAVAPGPIYTPLVSSTFPKEKIELSDQVPLGRMGQPVEVASCYLFLACSDGGYMTGQTLHPNGGTVINN
Protein: Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein homolog) (PsAPCDD1) (Q5R2J4)
Organism: Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
Function: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MSLPCCGRVRYLLLALLLHGLGEGSALLHPDSRSHPRSLEKSAWRAFKESQCHHMLKHLHNGARITVQMPPSIEGHWVSTGCEVRSGPEFITRSYRFYHNNTFKAYQFYYGGNRCTNPTYTLVIRGKIRLRQASWIIRGGTEADYQLHNVQIISHSEAVAEKLSQLVNRTCPGFVPGNSPWEQDVSYNLWREENGCECTRALNFAMHELQLIRVEKQYLHHNLDHLVEELFLGDIHTDATQRMYYRPSSYQPPLQNAKNHDHSCIACRIIYRSDEHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPICKHPTFTIYAKGRYSRGVHSSKVMGGTEFVFKVNHMKVTPMDIATASLLNVFNGNECGAEGSWQVGVQQDVTHTNGCVALGIRLPHTEYEIFKMEQNARGSYLLYNGQRPSDGSSPDRPEKRATSYQMPLVQCASSAPRPEESAEENKIGRYSSRAPKKDSSVFMLTLMLFICTGSHWNIHS
Protein: Scavenger receptor (Q58SM7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
TCDRDGRLRGEKPFCASRGCARPEDPENGHVENLSLRADVVCHDGYVLVGGRTAYCDGERWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFSTTTEPTAPTGSNEQPLVYDXMSCSGRCGTSISASNITNNGIVMGCGCNDECLSDETCCLNYLEECTKELLTTTEDDISSLPPTVTSTSTSTTRKSTTTTTTSTTTTSTTTTKRPTTTTTTTKATTTKRTTTTKKPTTTSTTPKPTTTTSTTPKSTTSTTSTTSTTPTTTTTINVFTTKKTTIMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIEGHMDTSGSTPNPALVVLYLLLGIVLVVVLANVVNRWIIPITGSKTSSEKAVRFKKAFDSLKKQRKRNSMDDQPLCDSDNDDVEYFEEMGVDIRHRTDL
Protein: Lambda-carrageenase (EC 3.2.1.162) (Q0JRK4)
Organism: Pseudoalteromonas carrageenovora (Alteromonas carrageenovora)
Function: Hydrolyzes lambda-carrageenan with inversion of anomeric configuration. Does not hydrolyze iota- and kappa-carrageenans, agarose or porphyran.
Subcellular location: Secreted {ECO:0000269|PubMed:17269933}.
Interaction partners:
Sequence:
MKIKILSAMVASSLLIGCVIPTVKASQSAIKSIETNRTITKVRTGMLSGGSSIITTSYEGTVAAYKFNGEKLWENELSGFMNHDIWVQDINGDGLVEIFAANADGNVYCINSDGSLKWTFGLNEVPMNSVTVISDADKKYVVAGGYDKNLYYISTNGELLKTIESGTYSEEGVFGDGVKPEARTHTVNFVRPVKSSDGTEKLVVLGTNNSLQSSGRFYIFEPFADLPSEKSRISIKKGIGDLRTVDFDNDGNDELTLGNSAQIGDAAISVMNLDDLSQKKSQINDIARRIDRFGYRVAQTEVVMNEGTPTYLTLFGSRILLTPESFDVNDSEILANKYSYYDMWKDKSSNKLVLASAQSGGSQVHIIDTSNPSWKSAYEELEPQGKLAAIQENTRAIERQLSNFQKPTRERAPLPVYFISESRNEIPTTIERSEFLYDSPVFLNYSTLPNVENWDRSEVLADNPKYRDKRDRRKNYTLSSEEMFNKLSAGYDNSDGISQWAGHGNDPYMISLATMKRIISSGDGKKTVNIYPEIEGHGDAFNKVLSDHFYPLAEFSSENNANLFMRNKHTFWQSTIYAPEWSELRSGRLADAFVPAMEETTDKSMEMSVAGRMGLWAAGSVDNWGERYARDNPSFDRLRQHSHQMVPNHALRQIIYKIASGARYINNFGFNQEYMSLAWELIGKGALYVPKREELLSLSPVHISMKEPDPIYRETSNNVKWTTFYDEEKDSIPYVFSRLNGTWPGAKTLPWDYSNYAADTKERRLDFIPKFPKGLVLITPVQQGKFKDEGTVRGTLADNMHPIYKDIMKEYITDGKNYYNPNGEQVMAADSVRYRQIKNKIEEKSNLLPMTVSGEAAWVVAQSAEKHLRLTLVDSGYLNPSNKVAKVKFNSVTPVAIVDVLSGETFSPDSNGVVEIPVLAGAFRFIDVKITEDLRNMQSSTL
Protein: Uncharacterized membrane protein YhhN (P0ADI9)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLWSFIAVCLSAWLSVDASYRGPTWQRWVFKPLTLLLLLLLAWQAPMFDAISYLVLAGLCASLLGDALTLLPRQRLMYAIGAFFLSHLLYTIYFASQMTLSFFWPLPLVLLVLGALLLAIIWTRLEEYRWPICTFIGMTLVMVWLAGELWFFRPTAPALSAFVGASLLFISNFVWLGSHYRRRFRADNAIAAACYFAGHFLIVRSLYL
Protein: Uncharacterized WD repeat-containing protein C17D11.16 (Q9P775)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- mRNA export factor elf1
- Nucleolar protein 12
- Ribosome biogenesis protein brx1
- Probable rRNA-processing protein ebp2
- Ribosome production factor 2 homolog
- Probable U3 small nucleolar RNA-associated protein 13
- Protein sda1
- Probable nucleolar GTP-binding protein 1
- Ribosome biogenesis protein erb1
- Ribosome assembly protein 4
Sequence:
MSIVSSVAFVPRGYASEFPKSYDIDEIEYERINQLSKLKLEDARADLQSSMEDSNKANGNGEETTDGAEGVLQTSEEVDDELKVYNLDTYDDDEEEAETEGPAAMFSNIRGLAYHENGEKDPYITIDPQEQDDLEREEMQILPTDSLLLAARTEDNLSHVEVYVYEPTEENLYVHHDFLLPTFPLCLEWLDYKVGTSDNAPGNYVAVGTFDPEIEIWDLDIIDAVYPAAVLGAGASQVNKKKKKSKKINDSYHTDAVLALSSNRNAHNLLVSGSADTTLKLWDLSTCNCVKSFTYHSDKVSCLDWYSKAPSVLLSGSYDKTAKIADLRLEEAPSSFQVTSDVENVAWDQHSENNFFIGTDNGIVYYCDARNLSKSVWQLQAHDGPISCLSVNPSVPSFVATGSTDRVVKLWNTSDSSPKMVVSRDLDVGRVFTCSFTTDESTAFHLAASGSKGVVRVWDTATNPGVRKAFESRVTEEVTKKERIVQLEDRGAGEDSSDDDDYEDIEDDDDQDAEMS
Protein: 26S proteasome regulatory subunit 7 homolog (Protein CIM5) (Tat-binding homolog 3) (P33299)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 26S proteasome regulatory subunit RPN9
- Probable 26S proteasome regulatory subunit p28
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit RPN13
- Proteasome subunit alpha type-5
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit RPN2
- Proteasome subunit alpha type-1
- Probable proteasome subunit alpha type-7
Sequence:
MPPKEDWEKYKAPLEDDDKKPDDDKIVPLTEGDIQVLKSYGAAPYAAKLKQTENDLKDIEARIKEKAGVKESDTGLAPSHLWDIMGDRQRLGEEHPLQVARCTKIIKGNGESDETTTDNNNSGNSNSNSNQQSTDADEDDEDAKYVINLKQIAKFVVGLGERVSPTDIEEGMRVGVDRSKYNIELPLPPRIDPSVTMMTVEEKPDVTYSDVGGCKDQIEKLREVVELPLLSPERFATLGIDPPKGILLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLDGFDPRGNIKVMFATNRPNTLDPALLRPGRIDRKVEFSLPDLEGRANIFRIHSKSMSVERGIRWELISRLCPNSTGAELRSVCTEAGMFAIRARRKVATEKDFLKAVDKVISGYKKFSSTSRYMQYN
Protein: WD repeat-containing protein 70 (Q9NW82)
Organism: Homo sapiens (Human)
Interaction partners:
- Protein BUD31 homolog
- Nuclear pore complex protein Nup155
- Ciliogenesis and planar polarity effector 1
- Pre-mRNA-processing-splicing factor 8
- Crooked neck-like protein 1
- Pre-mRNA-splicing factor CWC22 homolog
- SNW domain-containing protein 1
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
- Pre-mRNA-processing factor 19
Sequence:
MERSGPSEVTGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKEEEMNREKELRRQNEDIEPTSSRSNVVRDCSKSSSRDTSSSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEEEEEAEEEEEEEEEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDSGTDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSIQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDSPYWVSPAYSKTQPKTMFAQVESDDEEAKNEPEWKKRKI
Protein: Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4) (Q8N205)
Organism: Homo sapiens (Human)
Function: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).
Subcellular location: Nucleus outer membrane {ECO:0000269|PubMed:23348741}; Single-pass type IV membrane protein {ECO:0000269|PubMed:23348741}. Note=Localization at the nucleus outer membrane requires the presence of SUN1. {ECO:0000250}.
Interaction partners:
- SUN domain-containing protein 1
- SUN domain-containing protein 2
- Nesprin-3
- Kinesin-1 heavy chain
- Protein KASH5
- Nesprin-1
- Plectin
- Kinesin light chain 3
- Kinesin light chain 1
- Nesprin-2
Sequence:
MALSLPLGPRLGSEPLNHPPGAPREADIVGCTVCPASGEESTSPEQAQTLGQDSLGPPEHFQGGPRGNEPAAHPPRWSTPSSYEDPAGGKHCEHPISGLEVLEAEQNSLHLCLLGLGRRLQDLEQGLGHWALAQSGMVQLQALQVDLRGAAERVEALLAFGEGLAQRSEPRAWAALEQILRALGAYRDSIFRRLWQLQAQLVSYSLVFEEANTLDQDLEVEGDSDWPGPGGVWGPWAPSSLPTSTELEWDPAGDIGGLGPLGQKTARTLGVPCELCGQRGPQGRGQGLEEADTSHSRQDMLESGLGHQKRLARHQRHSLLRKPQDKKRQASPHLQDVRLEGNPGAPDPASRQPLTFLLILFLLFLLLVGAMFLLPASGGPCCSHARIPRTPYLVLSYVNGLPPV
Protein: Structural maintenance of chromosomes protein 4 (AtSMC4) (SMC protein 4) (SMC-4) (Chromosome-associated protein C) (AtCAP-C) (Q9FJL0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis.
Subcellular location: Nucleus. Note=Associates with chromatin. {ECO:0000250}.
Interaction partners:
- Condensin complex subunit 2
- ARM repeat superfamily protein
- Condensin-1 complex subunit CAP-D2
- Structural maintenance of chromosomes protein 2-1
- Structural maintenance of chromosomes protein 2-2
- Sister-chromatid cohesion protein 3
- Condensin-2 complex subunit H2
- Sister chromatid cohesion protein SCC2
- Protein CHROMOSOME TRANSMISSION FIDELITY 7
- Mitogen-activated protein kinase kinase kinase 21
Sequence:
MEEDEPMGGGESEPEQRKSGTPRLYIKELVMRNFKSYAGEQRVGPFHKSFSAVVGPNGSGKSNVIDAMLFVFGKRAKQMRLNKVSELIHNSTNHQNLDSAGVSVQFEEIIDLENGLYETVPGSDFMITRVAFRDNSSKYYINERSSNFTEVTKKLKGKGVDLDNNRFLILQGEVEQISLMKPKAQGPHDEGFLEYLEDIIGTNKYVEKIDELNKQLETLNESRSGVVQMVKLAEKERDNLEGLKDEAETYMLKELSHLKWQEKATKMAYEDTVAKITEQRDSLQNLENSLKDERVKMDESNEELKKFESVHEKHKKRQEVLDNELRACKEKFKEFERQDVKHREDLKHVKQKIKKLEDKLEKDSSKIGDMTKESEDSSNLIPKLQENIPKLQKVLLDEEKKLEEIKAIAKVETEGYRSELTKIRAELEPWEKDLIVHRGKLDVASSESELLSKKHEAALKAFTDAQKQLSDISTRKKEKAAATTSWKADIKKKKQEAIEARKVEEESLKEQETLVPQEQAAREKVAELKSAMNSEKSQNEVLKAVLRAKENNQIEGIYGRMGDLGAIDAKYDVAISTACAGLDYIVVETTSSAQACVELLRKGNLGFATFMILEKQTDHIHKLKEKVKTPEDVPRLFDLVRVKDERMKLAFYAALGNTVVAKDLDQATRIAYGGNREFRRVVALDGALFEKSGTMSGGGGKARGGRMGTSIRATGVSGEAVANAENELSKIVDMLNNIREKVGNAVRQYRAAENEVSGLEMELAKSQREIESLNSEHNYLEKQLASLEAASQPKTDEIDRLKELKKIISKEEKEIENLEKGSKQLKDKLQTNIENAGGEKLKGQKAKVEKIQTDIDKNNTEINRCNVQIETNQKLIKKLTKGIEEATREKERLEGEKENLHVTFKDITQKAFEIQETYKKTQQLIDEHKDVLTGAKSDYENLKKSVDELKASRVDAEFKVQDMKKKYNELEMREKGYKKKLNDLQIAFTKHMEQIQKDLVDPDKLQATLMDNNLNEACDLKRALEMVALLEAQLKELNPNLDSIAEYRSKVELYNGRVDELNSVTQERDDTRKQYDELRKRRLDEFMAGFNTISLKLKEMYQMITLGGDAELELVDSLDPFSEGVVFSVRPPKKSWKNIANLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFKNVSIVGHYVKDRTKDAQFIIISLRNNMFELADRLVGIYKTDNCTKSITINPGSFAVCQKTPA
Protein: Large ribosomal subunit protein uL29m (Q8T3V6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL22m
- Large ribosomal subunit protein uL30m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein uS5m
- Large ribosomal subunit protein uL13m
Sequence:
MSSALIKCLNLAKTVGNATVRSFLAAPKQPWQSCSAAALQTPHVQMPMQMHTSAVRRDLMEFFDDKKNWSENEVKVGRAWRTEELRIKSNKELHQLWFVLLKERNMLLTMEHECNDKMEVFPSPERIDKVKISMENLETVVRERNKAYHLLETGETGERPQKAVKNAFGLQVSYKACEHALPPFMNLKWIKSRNIGYGGRAVNRFLLKYREKLYNAKRKAKNRSRNEVMMILRRNPNFDLDVLRRQFPDVNVDKLRNEDKIRGHYVPKVGV
Protein: E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A) (Q13049)
Organism: Homo sapiens (Human)
Function: Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:37543647}. Mitochondrion {ECO:0000269|PubMed:22745133, ECO:0000269|PubMed:32918979}. Endoplasmic reticulum {ECO:0000269|PubMed:22745133}. Note=Localized in cytoplasmic bodies, often located around the nucleus. {ECO:0000269|PubMed:19349376}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 N
- Protein argonaute-1
- Stimulator of interferon genes protein
- Ubiquitin-conjugating enzyme E2 D1
- E3 ubiquitin-protein ligase TRIM56
- Ribitol 5-phosphate transferase FKRP
- Abl interactor 2
- Calpain-3
- Dysbindin
- Ubiquitin conjugating enzyme E2 V1
Sequence:
MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQARYKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRTVNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEILHFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP
Protein: Uncharacterized protein AT4g03830 (Q9M107)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein phosphatase EYA
Sequence:
MPPKRIQREVYSIDGQFGTYTSSQSTSRRLSLLKGAHGIPGRINLISPEATDSPETPSPGHACAFEIFFSECGLYFPLPDILIDFMHEFGIALPQLCPNVIRTILSLLTLAEEDNFLLSLPDLLQLYAIKKGRTQGTFFLSPRKGFRVFEDFPEKDEQWRKSFFFFRVNELTFGEKTGLFVSEWSARAASVDLLPISKTFASHFSSFVRQDLGWESLSSDRVRASGKRLRSRTDLAISSPPFEPRIFSEEEMSAPSYRAEKKMERERAKQEKDRLKSDKVVMTGTLEDSKLQAANKAKQPRAEEDGGARQKPSTLASKNDAPAPDSRTPSKATSSRDPSKRYGDKKRKQSDKDARSPARSVRVRTEERDASPSQQKEKGKKGDSQDLVKSIPLNAPFLRDTDNLLSSGHVSAPPLPFADLVRSFTHAGAPIPPLKELKPTNQENYLRFAEKLGELSDKDREIESFKQNEEENSRMVDRANSVLSRMREAEARVLALDIANTDLAAKLESGKNAYLAAIDNENRARAELLACEEKLRKLEEGQAALLADARREERRKVRAQFKDFTSKYQSFYAESEEV
Protein: Uveal autoantigen with coiled-coil/ankyrin (Q8VYF2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MADQTSDSTSPVAPLSVSSPTATKKDNTNPVDSKLTELNESRAELLNRIQNLKQDLQSWRGKLDTQVKVYREELSGLKKTLNLEVEQLREEFKDLKTTLNQQQDDVSASLKSLGLQDSKEQIDKRSEVTEEKVEALSTDDNAKEAEH
Protein: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38) (P28907)
Organism: Homo sapiens (Human)
Function: Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Subcellular location: Cell surface {ECO:0000269|PubMed:2319135}. Membrane {ECO:0000269|PubMed:8253715}; Single-pass type II membrane protein.
Interaction partners:
- Platelet endothelial cell adhesion molecule
- Hematopoietic progenitor cell antigen CD34
- Nicotinamide phosphoribosyltransferase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- B-lymphocyte antigen CD19
- NAD-dependent protein deacetylase sirtuin-1
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- NAD-dependent protein deacetylase sirtuin-3, mitochondrial
- T-cell surface glycoprotein CD4
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Sequence:
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
Protein: 26S rRNA (cytosine-C(5))-methyltransferase nsun-1 (EC 2.1.1.-) (5-methylcytosine rRNA methyltransferase nsun-1) (NOL1/NOP2/Sun domain family member 1) (RNA cytosine C(5)-methyltransferase nsun-1) (rRNA cytosine C(5)-methyltransferase nsun-1) (Q9TYV5)
Organism: Caenorhabditis elegans
Function: Methyltransferase which methylates the carbon-5 position of cytosine 2982 to 5-methylcytosine (m5C2982) in 26S rRNA. May play a role in the translation of leucine and proline codons (Probable). May be required for the translation of specific mRNAs such as mRNAs involved in gonad development, collagen production and cuticle integrity. Plays a role in ensuring the correct localization of the germline-specific protein gld-1 during development. Not required for pre-rRNA processing, the production of mature 5S, 5.8S, 18S or 26S rRNAs or global translation. Plays a role in positively regulating fertility.
Subcellular location: Nucleus, nucleolus {ECO:0000305}.
Interaction partners:
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Nucleolar complex protein 2 homolog
- Nucleolar GTP-binding protein 1
- Probable rRNA-processing protein EBP2 homolog
- Guanine nucleotide-binding protein-like 3 homolog
- Ribosome biogenesis protein BOP1 homolog
- ATP-dependent RNA helicase
- Putative rRNA methyltransferase
- RRM domain-containing protein
- Ribosome production factor 2 homolog
Sequence:
MAIVKKKKVSAASKAATEKPEVKKAVKRPVAETEAVTPKKKKLVKKVKKSAKKAHEEEPIEQVEKLQLIDDDEDGLEGLSFPGSDDEDLRDDYSDDDSDAGDHLPIEKKSAALDKQKEKIIAEGEEELQLNIANQATFELPTVEEIENEMKSVPNLEIVKQRIADVIQVLGDFKNRRDPQKSRENYVEVLKKDLCSQYGYNDYLMGKFMDLFPNGAELLEFLEANDNPRPVTIRANSLKVKRRDLAKNLINRGMNVDPAADWTKVGLVVYDSQVPVGATPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDANFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSKIRPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDANSPNGGYLVYSTCSVLVEENEAVVNFLLERRHCELVPTGLSIGVDGYTRFRDYRFHPSLSMTKRYYPHVHNIDGFYVAKIKKLSNAKMSKQGVMEKEKEKAAQKSQNKKNKAEAEASESSDDEEEKKNGVEVNGQKKPAKKQQQKKQKADGDDSDDDNNAPMKNIGSGARANKKRRNQKKAAEKQAAVKEDDGFNTVGNVKRAKKPTQFKSKVPKRAAARTGAKSVKNRRKKMLAKQQ
Protein: Replication initiator 1 (C9JYJ8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDGRRVPAQPAAEFSLTPGGYRSVGRSRRCSRGSIPRNIPKRSWKKPHPQLCSLQAEEEPMLERRCRGPLAMGLAQPRLLSGPSQESPQTLGKESRGLRQQGTSVAQSGAQAPGRAHRCAHCRRHFPGWVALWLHTRRCQARLPLPCPECGRRFRHAPFLALHRQVHAAATPDLGFACHLCGQSFRGWVALVLHLRAHSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICGNCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPRPRGRPAVTAPRPGGDAVDRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLLSHSKIHKRSEGSAQAAPGPGSPQLP