wanglab/gogpt-training-data huggingface dataset:
Protein: Cleavage and polyadenylation specificity factor subunit 3-II (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit II) (AtCPSF73-II) (CPSF 73 kDa subunit II) (Protein EMBRYO SAC DEVELOPMENT ARREST 26) (Q8GUU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. May function as mRNA 3'-end-processing endonuclease and also be involved in the histone 3'-end pre-mRNA processing.
Subcellular location: Nucleus {ECO:0000269|PubMed:16897494, ECO:0000269|PubMed:19573236}.
Interaction partners:
- Integrator complex subunit
- Protein SIEL
- Embryo defective 2739
- ARM repeat superfamily protein
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 1
- FIP1[V]-like protein
- 30-kDa cleavage and polyadenylation specificity factor 30
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- DNA-directed RNA polymerase II subunit 4
Sequence:
MAIDCLVLGAGQEIGKSCVVVTINGKKIMFDCGMHMGCDDHNRYPNFSLISKSGDFDNAISCIIITHFHMDHVGALPYFTEVCGYNGPIYMSYPTKALSPLMLEDYRRVMVDRRGEEELFTTTHIANCMKKVIAIDLKQTIQVDEDLQIRAYYAGHVLGAVMVYAKMGDAAIVYTGDYNMTTDRHLGAAKIDRLQLDLLISESTYATTIRGSKYPREREFLQAVHKCVAGGGKALIPSFALGRAQELCMLLDDYWERMNIKVPIYFSSGLTIQANMYYKMLISWTSQNVKEKHNTHNPFDFKNVKDFDRSLIHAPGPCVLFATPGMLCAGFSLEVFKHWAPSPLNLVALPGYSVAGTVGHKLMAGKPTTVDLYNGTKVDVRCKVHQVAFSPHTDAKGIMDLTKFLSPKNVVLVHGEKPSMMILKEKITSELDIPCFVPANGETVSFASTTYIKANASDMFLKSCSNPNFKFSNSTQLRVTDHRTADGVLVIEKSKKAKIVHQDEISEVLHEKNHVVSLAHCCPVKVKGESEDDDVDLIKQLSAKILKTVSGAQIHESENCLQVASFKGSLCLKDKCMHRSSSSSSEAVFLCCNWSIADLELGWEIINAIKLNH
Protein: Glyceraldehyde-3-phosphate dehydrogenase, NADP-dependent (EC 1.2.1.9) (A0A6L8PK77)
Organism: Bacillus anthracis
Interaction partners:
Sequence:
MTTSNTYKFYLNGEWRESSSGETIEIPSPYLHEVIGQVQAITRGEVDEAIASAKEAQKSWAEASLQDRAKYLYKWADELVNMQDEIADIIMKEVGKGYKDAKKEVVRTADFIRYTIEEALHMHGESMMGDSFPGGTKSKLAIIQRAPLGVVLAIAPFNYPVNLSAAKLAPALIMGNAVIFKPATQGAISGIKMVEALHKAGLPQGLVNVATGRGSVIGDYLVEHEGINMVSFTGGTNTGKHLAKKASMIPLVLELGGKDPGIVREDADLQDAANHIVSGAFSYSGQRCTAIKRVLVHENVADELVSLVKEQVAKLSVGSPEQDSTIVPLIDDKSADLVQGLVDDAVEKGATIVIGNKRERNLIYPTLIDHVTEEMKVAWEEPFGPILPIIRVSSDEQAIEIANKSEFGLQASVFTKDINKAFAIANKIETGSVQINGRTERGPDHFPFIGVKGSGMGAQGIRKSLESMTREKVTVLNLV
Protein: Isocitrate dehydrogenase [NAD(+)] 1, mitochondrial (PtIDH1) (EC 1.1.1.41) (B7G620)
Organism: Phaeodactylum tricornutum (strain CCAP 1055/1)
Function: Performs an essential role in the oxidative function of the tricarboxylic acid cycle and respiration (By similarity). Catalyzes the decarboxylation of isocitrate to produce 2-oxoglutarate and generate NADH to provide electrons for energy production. No activity with NADP(+).
Subcellular location: Mitochondrion {ECO:0000255, ECO:0000305|PubMed:32824636}.
Interaction partners:
- Citrate synthase
- malate dehydrogenase
- Succinate--CoA ligase subunit beta, mitochondrial
- 3-isopropylmalate dehydrogenase
- ATP-citrate synthase
- Succinate--CoA ligase subunit alpha, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal domain-containing protein
- Glutamate dehydrogenase
- Acyl-coenzyme A oxidase
Sequence:
MSSLSTLRILHSTAGRRWASYYGIYPKSAACSSSSVAIARFFSTAADRPPKHAMLSVENKVVAPPMVYIAGEEMTRYACDLVVKSWLEPYFDLSQWEYFDLSCVNRDNTNDQVLRDAVTAGQRIGAIFKEPTITPSAIQKKAFGLKNSLGSPNGAMRAGWNGITISRDTIHIDGIELGYKRPVFFERHAVGGEYGAGWSKVGRGTLLTTYLPSDGRDPFVVDKRDLTDQHNVVVTYHNPYDNVEPLAHLFFQRCLDANITPYVVTKKTVFKWQEGFWAVMKDVFDEHYKSRFEEKGLLQACGGDLQHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSPGFITSNLVGKAPDGSLIKEFEASHGTVSDLWNDHLAGKETSLNPLGLVEAIVGALQHAAVLDAEKNPDDEHKVKARDQIFNFTTTLRTAMHNTFRYGQGTRDMSGPSGYTTEDFVRKVAWRLQRYLDAQYDEAPPPQLGEPSRKLRRNYDIDEEAINGLFQKYDKNGDGFIDFEEFTRMLVKMNLAPLLTKKEKEKKPDV
Protein: Glutathione gamma-glutamylcysteinyltransferase (EC 2.3.2.15) (Phytochelatin synthase) (PC synthase) (A5JYS0)
Organism: Caenorhabditis elegans
Function: Involved in the synthesis of phytochelatins, which are heavy metal binding proteins required for the detoxification of heavy metals such as cadmium, arsenic and copper.
Interaction partners:
- Heavy metal tolerance factor 1
- Metallothionein-2
- Metallothionein-1
Sequence:
MSQRRHFKMSVTAKNFYRRPLPETCIEFSSELGKKLFTEALVRGSANIYFKLASQFRTQDEPAYCGLSTLVMVLNALEVDPEKVWKAPWRFYHESMLDCCVPLENIRKSGINLQQFSCLAKCNRLKSTVSYGDNSPDFLKKFRTSLVNSVRSDDQVLVASYDRSVLGQTGSGHFSPLAAYHEDSDQVLIMDVARFKYPPHWVKLETLQKALCSVDVTTKLPRGLVELELKKGTRPLIMYGLKAYVNINDSDFATSVISWNQFLLCDPLEDDEEEFQLCCRKFGQCFAPHAMCCTQKTFDADQKNSCTECSTDQNEACKMICSEIRRTRFAEVFSSSAVAALLIAWPFEKGYSERSDRIGNLAEKYKNEFSAETMNEMNQLTTQIRTLISCSKPPVVININKPDATSNKCCKNKIGQSCACANDVNL
Protein: Type II secretion system protein L (T2SS protein L) (E0SLF6)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004377}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004377}.
Interaction partners:
- Type II secretion system protein M
- Type II secretion system protein J
- Type II secretion system protein H
- Type II secretion system protein E
- Type II secretion system core protein G
- Type II secretion system protein C
- Type II secretion system protein K
- Secretin OutD
- Type II secretion system protein I
- Type II secretion system protein F
Sequence:
MNRAENASGKQQLILRLSTETSDSLEWLIWSVSRHQTLTQGSGTLERLQTVLADYPVMSVRVLVPSTDVTFHSLSLPRQSRRQLLQAIPFMLEEQVASDIDQLHFAVMEMQGDNATVAVVQKSRLRSWLNQCETLGVPVETMVPDVMALPRTDSAWSAISHQNLWLFRLDSGIGMAAEDSWYQSLLAGFQPLPAVHCYSPVPASALTWQPQPVTDLLTLAAQASLPISMDLRQGEYAPVKPWKQAVLPWRNVLIALFAWLLLVLGESVWTHYQLYRQADYWRQESVRMYRKLFPDEKQVVNPRAQMQRHLQEARSGMSGFALTEQMNRLQQLVAQNDGVSLQSLSYDRSRDELRLSLRATSYAQMEQFRQQAQAYFQIPPGEMKQEKDHVEGQLILRSQP
Protein: Sycp3 like Y-linked (A0A087WNQ6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
METLKVFLGTGDVRNDIYKTLHIKRKWMETYVKESFKGSNQKLERFCKTNERERKNINNKFCEQYITTFQKSDMDVQKFNEEKEKSVNSCQKEQQALKLSKCSQNQTLEA
Protein: ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) (Q8R4Z4)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
Interaction partners:
- Probable ATP-dependent RNA helicase DDX20
- Myc proto-oncogene protein
- Forkhead box protein O3
- Max dimerization protein 1
- Histone deacetylase 2
- T-box transcription factor TBX18
- T-box transcription factor TBX15
- Protein max
- Histone deacetylase 5
- Myc box-dependent-interacting protein 1
Sequence:
MKAGCSIVEKPEGGGGYQFPDWAYKAESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVMPNYPFINIRSSGVVPQSAPPVPTASSRFHFPPLDSHSPTGDVQPGRFSASSLSASGPESGVTTDRKVEPSDLEDGSASDWHRGMDFMPSRNALGGGAVGHQKRKPDILLPLFTRPAMYPDPHSPFAISPVPGRGGVLNVPISPALSLTPTMFSYSPSPGLSPFTSSSCFSFNPEEMKHYLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQMHPEEPSQFSIKLQPPPAGRKNRERVESREEAVRGSVPASAPVPSRIKVEPATEKDPDSLRQSTQGKEEQTQEVDSMRSRTIEEGKGTGFAHPSPTWPSVSISTPSDEPLEGTEDSEDRSVREPGVPEKKEDALMPPKLRLKRRWNDDPEARELNKTGKFLWNGAGPQGLATTATAAADA
Protein: Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) (Q53HL2)
Organism: Homo sapiens (Human)
Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:18946085}. Cytoplasm {ECO:0000269|PubMed:18946085}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15561729}. Chromosome, centromere {ECO:0000269|PubMed:20739936}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. {ECO:0000269|PubMed:18946085}.
Interaction partners:
- Inner centromere protein
- Aurora kinase B
- Baculoviral IAP repeat-containing protein 5
- Shugoshin 1
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Cell division cycle protein 20 homolog
- Cyclin-dependent kinase 1
- ATP synthase F
- G2/mitotic-specific cyclin-B1
- Kinesin-like protein KIF20A
Sequence:
MAPRKGSSRVAKTNSLRRRKLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMNWLDYFALGGNKQALEEAATADLDITEINKLTAEAIQTPLKSAKTRKVIQVDEMIVEEEEEEENERKNLQTARVKRCPPSKKRTQSIQGKGKGKRSSRANTVTPAVGRLEVSMVKPTPGLTPRFDSRVFKTPGLRTPAAGERIYNISGNGSPLADSKEIFLTVPVGGGESLRLLASDLQRHSIAQLDPEALGNIKKLSNRLAQICSSIRTHK
Protein: Protein phosphatase EYA2 (EC 3.1.3.48) (Eyes absent homolog 2) (O00167)
Organism: Homo sapiens (Human)
Function: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10906137, ECO:0000269|PubMed:12500905}. Nucleus {ECO:0000269|PubMed:10906137, ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19497856}. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2 (PubMed:10906137). Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus (PubMed:10906137, PubMed:12500905). {ECO:0000269|PubMed:10906137, ECO:0000269|PubMed:12500905}.
Interaction partners:
- Homeobox protein SIX1
- Homeobox protein SIX4
- Homeobox protein SIX2
- Paired box protein Pax-3
- Dachshund homolog 2
- Dachshund homolog 1
- Myogenin
- Homeobox protein MOX-1
- Homeobox protein SIX6
Sequence:
MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL
Protein: Activated in Blocked Unfolded protein response (O16502)
Organism: Caenorhabditis elegans
Interaction partners:
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- LiPocalin-Related protein
- Activated in Blocked Unfolded protein response
Sequence:
MRFTSLAIAFLACALVVSGSVIREKRQCGCAQPQQSQCSCQQVQQTQSCSCQSAPVQQQSPSCSCAQPQQTQQVQVQSTQCAPACQQSCQQQCQASPSVSQCQPQCQQQCQAQCTPMYNPPTTTTTTQAPVVQYQQCQPVCQQQCQSTCVQQQQPAAQCQPQCQQQCNVACDSPSTTTQAPQVIQIQLEIQQAQAQCQPQCQQQCQSSCVQQQQPSTQCEPACNTQCSDICQQTAQATQQVYNQNMNQNTNTQMYNPYNTNTNQNANCAPACQPACDNSCTSQQAQPVYQQAQPTYQVQQTTAAPMYDPYNNQGSANCAPACQPACDNSCTSQQTQPMYQPYDTTTEAPAQVIQIVLQTSVAQSSQCAPQCEQSCQQQCVQQQQPAAQCQTACQSSCSNSCQTAQPATTACQQSPQQSSCSCQANYSPCGNGQCCRRK
Protein: Zinc metalloproteinase partitagin (EC 3.4.24.-) (P85975)
Organism: Hippasa partita (Funnel-web spider) (Hippasa deserticola)
Function: Zinc metalloproteinase that causes hemorrhage in mice following intradermal injection and impairs hemostasis in its prey. In skin tissues, it degrades components of the basement membrane surrounding blood vessels and capillaries. In muscle tissue, it degrades the extracellular matrix, thus causing muscle necrosis. However, it lacks direct toxicity on myocytes. Hydrolyzes alpha-2 chain (COL4A2) of type IV collagen more slowly than the alpha-1 chain (COL4A1). Hydrolyzes fibronectin (FN1). It also impairs hemostasis by acting on fibrin(ogen) and platelets. Shows fibrinolytic activity, with a selective degradation of gamma-dimer (FGG). Shows fibrinogenolytic activity by preferentially cleaving the Bbeta chain, and later gamma-chain. Aalpha-chain remains resistant to proteolytic digestion. Weakly inhibits collagen-triggered platelet aggregation of human plasma rich platelet.
Subcellular location: Secreted {ECO:0000269|PubMed:17555860}.
Interaction partners:
Sequence:
AYDPDPYKRYSAEHTFFLL
Protein: Steroidogenic acute regulatory protein, mitochondrial (StAR) (START domain-containing protein 1) (StARD1) (P49675)
Organism: Homo sapiens (Human)
Function: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P51557}.
Interaction partners:
- Non-selective voltage-gated ion channel VDAC1
- Translocator protein
- STARD3 N-terminal-like protein
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Steroidogenic factor 1
- Non-selective voltage-gated ion channel VDAC2
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Adrenodoxin, mitochondrial
- Cytochrome P450 11B2, mitochondrial
- Non-selective voltage-gated ion channel VDAC3
Sequence:
MLLATFKLCAGSSYRHMRNMKGLRQQAVMAISQELNRRALGGPTPSTWINQVRRRSSLLGSRLEETLYSDQELAYLQQGEEAMQKALGILSNQEGWKKESQQDNGDKVMSKVVPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELAAEAAGNLVGPRDFVSVRCAKRRGSTCVLAGMATDFGNMPEQKGVIRAEHGPTCMVLHPLAGSPSKTKLTWLLSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLESHPASEARC
Protein: AHA1, activator of heat shock protein ATPase homolog 1a (Activator of 90 kDa heat shock protein ATPase homolog 1a) (Q5RIK5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Stress-induced-phosphoprotein 1
- Heat shock protein HSP 90-alpha 1
- Prostaglandin E synthase 3
- Heat shock protein 90, alpha
- Peptidyl-prolyl cis-trans isomerase D
- Peptidylprolyl isomerase G
- peptidylprolyl isomerase
- Endoplasmin
- Heat shock protein HSP 90-beta
- Cysteine and histidine-rich domain-containing protein 1
Sequence:
MLIIGTERDVTSWSQDAINGLLLGIRVEGEEGTCEITDVSNIDGEASINNRKGKLIYFYEWVVKASWTGTNKIGIKYKGIVEIPNLSDENDMDDLDISVTLCKDQPNTPLTDLMRREGVKKIRMALGNYVKHLKTEFAQGMILPTENALFQQNQEAKAKVKLDKTQIGSPSTANAPSTGVKIATVSFSLKDTFLTSPEELYRIFITQEMVQAFTHLAAFVDGRCGGKFRLLEGNVHGQFAELIPDKKIAMRWRFASWPAGHAATVILNFVNQGSETELILEAKGVPSNEEERMKEGWQRYYFNAIKQTFGFGALLY
Protein: 5-methylthioadenosine/S-adenosylhomocysteine deaminase (MTA/SAH deaminase) (EC 3.5.4.28) (EC 3.5.4.31) (Q72B14)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Interaction partners:
- Purine nucleoside phosphorylase
- SPFH domain/Band 7 family protein
Sequence:
MPLPCDTILQAALIVTQDDARTVIEDGAIAIHEGRIAAVGQRDAIVGNWHGVTVIDMGESLIMPGLVNAHTHASMTLLRGLADDLPLMDWLTGHIFPVEKGLTGELVELGALLGCAEMLRTGTTAFSDMYLIEDATLRAVDRAGLRCLAGEAIFAFPSPAYADPETAFDLVRAQHDRWKHHARAALAVAPHAVYTSTPAILARCRDLAEELGLPIHLHLAETATETAQCIEQHGARPVPYCDGLGLLTPRTTLAHCVDLTEGEIDLLAERGVTVAHCPESNMKLASGIAPATAMLGRGMTLGLGTDGAASNNSLNMFTEMTSCALLHKVHHMDPTCAPASAVLDMATRGGAHALHMQGIGRIEAGCPADIIALDLRAPNMQPIFNPASHLVYAATGHETRLTMVGGEVLYLDGCYTRFDMDDLLKEVRKARTWAMEQVRAAR
Protein: CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b) (A8K4G0)
Organism: Homo sapiens (Human)
Function: Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- TYRO protein tyrosine kinase-binding protein
- CMRF35-like molecule 6
- CMRF35-like molecule 1
- Hematopoietic cell signal transducer
- CMRF35-like molecule 8
- High affinity immunoglobulin epsilon receptor subunit gamma
- CMRF35-like molecule 2
- Triggering receptor expressed on myeloid cells 1
- CMRF35-like molecule 5
Sequence:
MWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQGWETYIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVKVIVDPEGAASTTASSPTNSNMAVFIGSHKRNHYMLLVFVKVPILLILVTAILWLKGSQRVPEEPGEQPIYMNFSEPLTKDMAT
Protein: Cobalamin binding intrinsic factor (Gastric intrinsic factor) (Intrinsic factor) (IF) (INF) (P52787)
Organism: Mus musculus (Mouse)
Function: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Cubilin
- Potassium-transporting ATPase subunit beta
- Trefoil factor 2
- Protein amnionless
Sequence:
MAWLTLYLLSVLWAVAGTSTRAQSSCSVPPDQQPWVDGLQALMENSVTDSDFPNPSILIAMNLAGAYNVEAQKLLTYQLMASDSADLTSGQLALTVMALTSSCRDPGSKVSTLLKKMENWSPSSPGAESSAFYGPGLAILALCQKSSEATLPIAVRFAKTLMMEPSPFNVDTGAVATLALTCMYNKIPVGSQENYRDLFGQALKAIVEKISLRIKADGIIGDIYSTGLAMQALSVTPEQPTKKWDCEKTMHTILNEIKQGKFQNPMSIAQILPSLKGKTYLDVPQVTCGPDHEVPPTLTDYPTPVPTSVSNITVIYTINNQLRGVDLLFNVTIEVSVKSGSVLLAVLEEAQRKNSMFKFETTMTSWGLIVSSINNIAENVNHKTYWEFLSGKTPLDEGVAYYIPFNHEHITANFTQY
Protein: Battenin (F7F0I2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Lysosome membrane {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361113}.
Interaction partners:
Sequence:
MSWEALRARGGALRILRETDSEPQTPPLDNLSVLWKNAVGFWILGLCNNFSYVVMLSAAHDILKQEQASGNQSHVEPGPTPMPHNSSSRFDCNSISTAAVLLADILPTLVIKLLAPLGLHLLPYSPRVLVSGVCSAGSFVLVAFSQSVGLSLCGVVLASISSGLGEVTFLSLTAFYPSAVISWWSSGTGGAGLLGSLSYLGLTQAGLSPQHTLLSMLGIPVLMLASYFLLLTSPEPLDPGGQDEAETAARQPLIGTETPESRPGTSWDLSLQERWTVFKGLLRYIIPLVLVYFAEYFINQGLFELLFFRNTSLSHAQQYRWYQMLYQAGVFASRSSLQCCRIRFTWILALLQCLNLAFLLADVCLTFLPSIYLIFIVILYEGLLGGAAYVNTFHNIALETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCHLP
Protein: Transmembrane protein 120 homolog (Q9U1M2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Bestrophin homolog
Sequence:
MNIDSLKNEWEELNKEFAELESCNRRYIELLEQLHSHQQICFNEIKHQRYRMNQITTSLRQFKGPVPAEDKEKVDDLHKMTLKRKAQLHEIEQSLPAKSGRYLQIILGDVNVSILNRNDKVRYKDDYEKFKLILNVIGLIMAFFNLIFNYRALELAFIFLLVWYYCTLTIRESILKVNGSRIKGWWRAHHFISTVAAGVLLVWPQGEHWQIFRMQFMYFNVYISIVQYLQFGYQKGLLYRLKALGERHNMDITIEGFHSWMWRGLSFLLPFLFIGYGYQAYNAWTLYKLAYSPPDAPWHVSVMSGLFLLLFVGNMATTLWVVPEKIRERAKERYRLQSMGKSMKLRKEMKNSASDLDLSSGSKLSPTATTTTSIATATQTPAEKKET
Protein: Non-selective voltage-gated ion channel VDAC3 (VDAC-3) (rVDAC3) (Outer mitochondrial membrane protein porin 3) (Q9R1Z0)
Organism: Rattus norvegicus (Rat)
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). Involved in male fertility and sperm mitochondrial sheath formation (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21796}. Membrane {ECO:0000250|UniProtKB:Q9Y277}. Note=May localize to non-mitochondrial membranes. {ECO:0000250|UniProtKB:Q9Y277}.
Interaction partners:
- Non-selective voltage-gated ion channel VDAC1
- Non-selective voltage-gated ion channel VDAC2
- ADP/ATP translocase 1
- Creatine kinase U-type, mitochondrial
- Creatine kinase S-type
- ADP/ATP translocase 2
- Cytochrome c, somatic
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- ADP/ATP translocase
- Peptidyl-prolyl cis-trans isomerase D
Sequence:
MCSTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLIFTQKWNTDNTLGTEISWENKLAEGLKLTVDTIFVPNTGKKSGKLKASYRRDCFSVGSKVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLCQNNFALGYKAEDFQLHTHVNDGTEFGGSIYQRVNEKIETSINLAWTAGSNNTRFGIAAKYRLDCRTSLSAKVNNASLIGLGYTQSLRPGVKLTLSALVDGKNFNAGGHKVGLGFELEA
Protein: 60S ribosomal export protein NMD3 (Nonsense-mediated mRNA decay protein 3) (P38861)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. Unlikely to play a significant role in nonsense-mediated mRNA decay (NMD).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11086007}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11086007}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.
Interaction partners:
- Cytoplasmic 60S subunit biogenesis factor REI1
- Eukaryotic translation initiation factor 6
- Large ribosomal subunit protein uL16
- Probable metalloprotease ARX1
- Large subunit GTPase 1
- Nucleolar GTP-binding protein 1
- Ribosome biogenesis protein RLP24
- Exportin-1
- Bud site selection protein 20
- Ribosome assembly factor MRT4
Sequence:
MEFTPIDPHQHQNAATLLCCNCGTPIDGSTGLVMCYDCIKLTVDITQGIPREANISFCRNCERFLQPPGQWIRAELESRELLAICLRRLKGLTKVRLVDASFIWTEPHSRRIRIKLTVQGEAMTNTIIQQTFEVEYIVIAMQCPDCARSYTTNTWRATVQIRQKVPHKRTFLFLEQLILKHNAHVDTISISEAKDGLDFFYAQKNHAVKMIDFLNAVVPIKHKKSEELISQDTHTGASTYKFSYSVEIVPICKDDLVVLPKKLAKSMGNISQFVLCSKISNTVQFMDPTTLQTADLSPSVYWRAPFNALADVTQLVEFIVLDVDSTGISRGNRVLADITVARTSDLGVNDQVYYVRSHLGGICHAGDSVMGYFIANSNYNSDLFDGLNIDYVPDVVLVKKLYQRKSKKSRHWKLKRMAKEHKDIDASLDYNSRAQKQEMERAEKDYELFLQELEEDAELRQSVNLYKNREANVPPEEHEMDEDEDEDAPQINIDELLDELDEMTLEDGVENTPVESQQ
Protein: Histone H1.2 (P26569)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Probable histone H2A.3
- At5g08780
- Winged-helix DNA-binding transcription factor family protein
- Winged helix-turn-helix transcription repressor DNA-binding protein
- Winged-helix DNA-binding transcription factor family protein
- Regulator of chromosome condensation
- Putative regulator of chromosome condensation
- Protein SET DOMAIN GROUP 40
Sequence:
MSIEEENVPTTVDSGAADTTVKSPEKKPAAKGGKSKKTTTAKATKKPVKAAAPTKKKTTSSHPTYEEMIKDAIVTLKERTGSSQYAIQKFIEEKHKSLPPTFRKLLLVNLKRLVASEKLVKVKASFKIPSARSAATPKPAAPVKKKATVVAKPKGKVAAAVAPAKAKAAAKGTKKPAAKVVAKAKVTAKPKAKVTAAKPKSKSVAAVSKTKAVAAKPKAKERPAKASRTSTRTSPGKKVAAPAKKVAVTKKAPAKSVKVKSPAKRASTRKAKK