wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein 597 (Q96LX8)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Structural maintenance of chromosomes protein 6
- E3 SUMO-protein ligase NSE2
- Structural maintenance of chromosomes protein 5
- Non-structural maintenance of chromosomes element 1 homolog
- Non-structural maintenance of chromosomes element 3 homolog
- Non-structural maintenance of chromosomes element 4 homolog A
- M-phase phosphoprotein 8
- N-alpha-acetyltransferase 60
Sequence:
MASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLVPYPEKSSEDGVGNPEAKILSGTPTYKRRVISLLVTIENHTPLVELSEYLGTNTLSEILDSPWEGAKNVYKCPECDQNFSDHSYLVLHQKIHSGEKKHKCGDCGKIFNHRANLRTHRRIHTGEKPYKCAKCSASFRQHSHLSRHMNSHVKEKPYTCSICGRGFMWLPGLAQHQKSHSAENTYESTNCDKHFNEKPNLALPEETFVSGPQYQHTKCMKSFRQSLYPALSEKSHDEDSERCSDDGDNFFSFSKFKPLQCPDCDMTFPCFSELISHQNIHTEERPHKCKTCEESFALDSELACHQKSHMLAEPFKCTVCGKTFKSNLHLITHKRTHIKNTT
Protein: Phosphoenolpyruvate/phosphate translocator (Q8I0U9)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MNVLTRTLIITIFFNLQIYIGKCLNHDNIKNIKNVPMNFHLKNTNGKIYQKNKRPSQINRKNTNKQAFNIPVFSIPNYKPKYNTCTKTKNIAFVNSRINQAHNRNIQVTKAAELNAIKKIKNDKKFTLFNSGNRDNIKTYEHDINKGIIDDISTTNNSYSNIGDTSENTYQPNNFNNTLTEKKPCTFLNKAVEVGKTVSLLGMWYVCNIFYNIENKKALNILNMPITIAITQIYVGLPIFLIPWLLKLRNQPELFYDEQELKRINMSDRNALIKGFQKYVLFLKKYSSIMKQSIYHGYAHLLSVIAMGAGAISFVHIVKASAPLFAAFFSYFFMNNKMSIYTYSSLVPIVFGVSLASIKELSFTYKALYSTLSANVLSTMRAIEAKIMMGKNLDKLGRNLTPENIFALLTLSSAIFLTPALYIDSHKWKDAYEYLMNNKNVLKVLGRHVLMSGVWFYLYNQLSFISLNRLNHITHAVASTVKRVFLILTSYFIFGTKFSFLGGLGSSIAVGGTFVYSLVKKKFG
Protein: Probable transcriptional regulatory protein (Probably LuxR/UhpA-family) (O53720)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv1354c
Sequence:
MSKLLPRGTVTLLLADVEGSTWLWETHPDDMGAAVARLDKAVSGVIAAHDGVRPVEQGEGDSFVLAFACASDAVAAALDLQRARLAPIRLRIGVHTGEVALRDEGNYAGPTINRTARLRDLAHGGQTVLSGVTESLVIDRLPDKAWLVDLGTHALRDLSRPERVMQLCHPELRIDFPPLRVANDDVAHGLPVHLTRFVGRGAQITEVHRLVTDNRLVTLTGAGGVGKTRLAAQLAAQIAGEFGRAWFVDLAPITDPDLVPVTVAGALGLHDQPGRSTTDTVLRFLGGRPALVVLDNCEHLLDATAALVLALVKACRGVRLLATCREPLRVEGEVSYRVPSLSLSDEAVEMFCYRAQRVRPDFRLTDDNSAAVTEICKRLDGLPLAIELAAARLRSMTLDEIIDGLRDRFALLTGGARTAAHRQQTLWASVDWSYTLLTEPERTLFRRLAVFVGCFFVDDAQAVACSGDVQRYQVLDEITLLVDKSLVMADDNSGRTCYRLCETMRHYALEKLSEAGEVDAVFARHRDYYTALAARVDNPGPSDYSHCLDQAETEIDNLRAAFVWNRENSDTEGALALASSLLRVWMTRGRIQEGRAWFDSILADENARHLEVAAAVRARALADKALLDIFVDAAAGMEQAQQALVIAREVDEPALLSRALTACGLIAVAVARADAAASYFAEAIDLARAVDDRWRLAQILTFQAVDAVVAGDPVAARPAAQEARELAAAIGDHSNALWCRWCLGYAQLMRGELAAAAAQFGEVVDEAEASQEVLHKANSLQGLAFALAYQGELSAARAAADAALEAAELGEYFAGMGYSALTTAALAAGDVQTAQHASEAAWRNLSLALPLSAAVQRAFNAQAALAGGDLSAARRWCDDAVQSMTGHHLAMALATRARIAVAEGKREEAERDAHKALACAAESGAHLDLPDVLECLAGLASDAGTHHAAARLFGAAEAIRQQIGSVRFAIYRSDYVQSVTALRDAMGEKDFDAAWAEGAALSIKETIAYAQRGHSWRKRPATGWESLTPTEIDVVRLVGEGLANKDIATRLFVSPRTVQTHLTHVYTKLGFTSRLQLAQAAARRT
Protein: Lipase (Q7ZTR9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MLWLVLSLVILTSGLVQYGQSALDGTGLDPEVNMNISEIIRHWGYPAEEFEVVTEDGYILSINRIPHGVKNKNEEVKPVVFLQHGLLAAGSNWVTNLPNNSLGFVLADAGFDVWIGNSRGNTWSCKHVSLDPRQKEYWKFSHDEMAKKDLPAVINFITKMTGQEQIFYVGHSQGTTIAFMAFSTMPELASKIKMFFALAPVATVGMTKSPMTKLSVIPEFLIWDLFGQKDFFPQNELIKFFATEFCSRKPLSVLCGNVFFLLCGFDEKNLNMSRTPVYTAHCPAGTSVQNMIHWAQAVKSSKLMAYDYGRAGNMAHYNQSTPPLYNIQDMMVPTAVWSGGQDTLADPKDVALLLTQIPKLVYKRDIKHWEHLDFIWGMDAPQEMYEKMIEIMRENV
Protein: High-affinity branched-chain amino acid transport system permease protein BraD (P21627)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein
- High-affinity branched-chain amino acid transport system permease protein BraE
- High-affinity branched-chain amino acid transport ATP-binding protein BraF
- High-affinity branched-chain amino acid transport ATP-binding protein BraG
- Branched chain amino acid ABC transporter ATP binding protein
- Amino acid binding protein
- Probable permease of ABC branched-chain amino acid transporter
- High-affinity branched-chain amino acid transport ATP-binding protein
- Aliphatic amidase expression-regulating protein
- Branched chain amino acid ABC transporter membrane protein
Sequence:
MPEIYHYLQQLVNGLTVGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYIAFIAITLLAMMGLDSVPLMMLAAFAASIIVTSAFGYSIERVAYRPLRGGNRLIPLISAIGMSIFLQNAVMLSQDSKEKAIPTLLPGNFVFGESSMNGVVISYMQILIFVVTFLVMFGLTLFISRSRLGRACRACAEDLKMTNLLGINSNNIIALTFVIGAALAAVAAVLLGMQYGVINPGIGFLAGIKAFTAAVLGGIGSIPGAMLGGLLLGVAEAFGADVFGDQYKDVVAFGLLILVLLFRPTGILGRPEVEKV
Protein: AP-1-like transcription factor YAP1 (Phenanthroline resistance protein PAR1) (Pleiotropic drug resistance protein PDR4) (P19880)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription activator involved in oxidative stress response and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes and components of the cellular thiol-reducing pathways, including the thioredoxin system (TRX2, TRR1), the glutaredoxin system (GSH1, GLR1), superoxide dismutase (SOD1, SOD2), glutathione peroxidase (GPX2), and thiol-specific peroxidases (TSA1, AHP1). The induction of some of these genes requires the cooperative action of both, YAP1 and SKN7. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Oxidative stress (as well as carbon stress, but not increased temperature, acidic pH, or ionic stress) induces nuclear accumulation and as a result YAP1 transcriptional activity. Activation by hydrogen peroxide or thiol-reactive chemicals elicit distinct adaptive gene responses. Nuclear export is restored when disulfide bonds are reduced by thioredoxin (TRX2), whose expression is controlled by YAP1, providing a mechanism for negative autoregulation. When overexpressed, YAP1 confers pleiotropic drug-resistance and increases cellular tolerance to cadmium, iron chelators and zinc.
Subcellular location: Nucleus {ECO:0000269|PubMed:11274141, ECO:0000269|PubMed:9130715, ECO:0000269|PubMed:9857197}. Cytoplasm {ECO:0000269|PubMed:11274141, ECO:0000269|PubMed:9130715, ECO:0000269|PubMed:9857197}. Note=Oxidized YAP1 is found predominantly in the nucleus, while reduced YAP1 is continuously exported to the cytoplasm by CRM1/exportin 1. Nuclear import requires the karyopherin PSE1/KAP121 and is independent on YAP1 oxidation state. {ECO:0000269|PubMed:11274141, ECO:0000269|PubMed:9130715, ECO:0000269|PubMed:9857197}.
Interaction partners:
- Transcription factor SKN7
- Thioredoxin-2
- Thioredoxin-1
- YAP1-binding protein 1
- Thioredoxin reductase 1
- Glutathione reductase
- Peroxiredoxin TSA1
- Glutathione peroxidase-like peroxiredoxin HYR1
- Arsenical-resistance protein ARR1
- Exportin-1
Sequence:
MSVSTAKRSLDVVSPGSLAEFEGSKSRHDEIENEHRRTGTRDGEDSEQPKKKGSKTSKKQDLDPETKQKRTAQNRAAQRAFRERKERKMKELEKKVQSLESIQQQNEVEATFLRDQLITLVNELKKYRPETRNDSKVLEYLARRDPNLHFSKNNVNHSNSEPIDTPNDDIQENVKQKMNFTFQYPLDNDNDNDNSKNVGKQLPSPNDPSHSAPMPINQTQKKLSDATDSSSATLDSLSNSNDVLNNTPNSSTSMDWLDNVIYTNRFVSGDDGSNSKTKNLDSNMFSNDFNFENQFDEQVSEFCSKMNQVCGTRQCPIPKKPISALDKEVFASSSILSSNSPALTNTWESHSNITDNTPANVIATDATKYENSFSGFGRLGFDMSANHYVVNDNSTGSTDSTGSTGNKNKKNNNNSDDVLPFISESPFDMNQVTNFFSPGSTGIGNNAASNTNPSLLQSSKEDIPFINANLAFPDDNSTNIQLQPFSESQSQNKFDYDMFFRDSSKEGNNLFGEFLEDDDDDKKAANMSDDESSLIKNQLINEEPELPKQYLQSVPGNESEISQKNGSSLQNADKINNGNDNDNDNDVVPSKEGSLLRCSEIWDRITTHPKYSDIDVDGLCSELMAKAKCSERGVVINAEDVQLALNKHMN
Protein: Large ribosomal subunit protein uL2 (50S ribosomal protein L2) (P9WHA5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
Interaction partners:
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein bL36
- Small ribosomal subunit protein bS20
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein bL35
Sequence:
MAIRKYKPTTPGRRGASVSDFAEITRSTPEKSLVRPLHGRGGRNAHGRITTRHKGGGHKRAYRMIDFRRNDKDGVNAKVAHIEYDPNRTARIALLHYLDGEKRYIIAPNGLSQGDVVESGANADIKPGNNLPLRNIPAGTLIHAVELRPGGGAKLARSAGSSIQLLGKEASYASLRMPSGEIRRVDVRCRATVGEVGNAEQANINWGKAGRMRWKGKRPSVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGKPEGRTRNANKSSNKFIVRRRRTGKKHSR
Protein: UPF0265 protein YeeX (P0A8M6)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Inner membrane protein YeeA
- ATP-dependent 6-phosphofructokinase isozyme 1
- Putative RNA-binding protein YbcJ
Sequence:
METTKPSFQDVLEFVRLFRRKNKLQREIQDVEKKIRDNQKRVLLLDNLSDYIKPGMSVEAIQGIIASMKGDYEDRVDDYIIKNAELSKERRDISKKLKAMGEMKNGEAK
Protein: Ceramide kinase (mCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Q8K4Q7)
Organism: Mus musculus (Mouse)
Function: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Shows a greater preference for D-erythro isomer of ceramides (By similarity). Binds phosphoinositides (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8TCT0}. Cell membrane {ECO:0000250|UniProtKB:Q8TCT0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8TCT0}.
Interaction partners:
- Ceramide glucosyltransferase
- Acid ceramidase
- Neutral ceramidase
- Sphingomyelin phosphodiesterase
- Ceramide synthase 2
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Alkaline ceramidase 2
- Sphingomyelin phosphodiesterase 2
- Ceramide synthase 4
- Ceramide synthase 5
Sequence:
MGAMGAAEPLHSVLWVKRRRCAVSLEPARALLRWWRSPEPGPSAPGADARSVLVSEIIAVEEKDDCEKHASSGRWHKMENPFAFTVHRVKRVRHHRWKWARVTFWSADEQLCHLWLQTLRGLLESLTSRPKHLLVFINPFGGKGQGKRIYEKTVAPLFTLASITTEIIITEHANQAKETLYEINTDSYDGIVCVGGDGMFSEVLHGVIGRTQQSAGIDPNHPRAVLVPSTLRIGIIPAGSTDCVCYSTVGTNDAETSALHIIIGDSLAIDVSSVHYHNTLLRYSVSLLGYGFYGDLIKDSEKKRWMGLVRYDFSGLKTFLSHQYYEGTLSFLPAQHTVGSPRDNKPCRAGCFVCRQSKQQLEEEEKKALYGLENAEEMEEWQVTCGKFLAINATNMSCACPRSPGGLSPFAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQEDQFDFTFVEVYRVKKFHFTSKHVEDEDNDSKEQEKQKFGKICKDRPSCTCSASRSSWNCDGEVMHSPAIEVRVHCQLVRLFARGIEEES
Protein: Paired box protein Pax-2a (No isthmus protein) (Pax[Zf-b]) (Q90268)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.
Subcellular location: Nucleus.
Interaction partners:
- LIM/homeobox protein Lhx1
- Homeobox protein OTX2
- Early growth response protein 2b
- Fibroblast growth factor 8
- Ventral anterior homeobox 1
- E3 SUMO-protein ligase EGR2a isoform 1
- Eyes absent homolog
- Sonic hedgehog protein
- Wilms tumor protein homolog
- Ventral anterior homeobox 2
Sequence:
MDIHCKADPFSAMHLSHIGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFHPSSDGTGTPLSTAGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDDVLWSGNHLDGRKIGYHGSDGSGPNSDSQGSVESLRKHLRADAFTQQQLEALDRVFERPSYPDVFPTSEHIKPEQANEYSLPALNPGLDEVKPSLSTSVSSDLGSSVSQSYPVVTGREMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSDFSGNPYSHPQYTTYNEAWRFSNPALLSSPYYYSAASRGSGPPTAATAYDRH
Protein: AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (Developmentally and sexually retarded with transient immune abnormalities protein) (Desrt) (MRF1-like) (Modulator recognition factor protein 2) (MRF-2) (Q8BM75)
Organism: Mus musculus (Mouse)
Function: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver (By similarity). Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:12215486}.
Interaction partners:
- Lysine-specific demethylase PHF2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- Protein polybromo-1
- Homeobox protein NANOG
Sequence:
MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWAHSDFSKWRCGLRATPVKTEAFGRNGQKEALLRYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENESVCDEFAPNLKGRPRKKKTCPQRRDSFSGSKDPNNNCDGKVISKVKGEARSALTKPKNNHNNCKKTSNEEKPKLSIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENNTQENENKTKVSGNKRIKQEMAKNKKEKENTPKPQDTSEVSSEQRKEEETLNHKSAPEPLPAPEVKGKPEGHKDLGARAPVSRADPEKANETDQGSNSEKEAEEMGDKGLAPLLPSPPLPPEKDSAPTPGAGKQPLASPSTQMDSKQEAKPCCFTESPEKDLQGAPFSSFSATKPPLTSQNEAEEEQLPATANYIANCTVKVDQLGSDDIHTALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIAREDLCSGLSQGHHSQSSDHTAVSRPSVIQHVQSFKNKASEDRKSINDIFKHDKLSRSDAHRCGFSKHQLGSLADSYILKQETQEGKDKLLEKRAVSHAHVPSFLADFYSSPHLHSLYRHTEHHLHNEQSSKYAARDAYQESENGAFLSHKHPEKIHVNYLASLHLQDKKVAAAEASTDDQPTDLSLPKNPHKLTSKVLGLAHSTSGSQEIKGASQFQVVSNQSRDCHPKACRVSPMTMSGPKKYPESLARSGKPHQVRLENFRKMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPAKEASGKEKASEQESEGNKGAYGGHSGAASEGHKLPLSTPIFPGLYSGSLCNSGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAGINPQAAFPSSQLSSVHPSTKL
Protein: Rap1 GTPase-GDP dissociation stimulator 1-A (Rap1gds1-A protein) (RalB-binding protein A) (XsmgGDS-A) (smgGDS-A) (O93614)
Organism: Xenopus laevis (African clawed frog)
Function: Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P52306}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P52306}. Mitochondrion {ECO:0000250|UniProtKB:P52306}.
Interaction partners:
Sequence:
MDNLNDALEKLKLTGTECTSDKLDGCFDCLLQALGHNNTESSEKIQQSGILQLFASILNSQSSCASKVAHIVAEIAKNELMRIPCVEAGLIPPLVQLLHSKDQEVLLQTGRALGNICYDNHEGRRAVDQEGGAQIVVDHLRSMCTLTDPSSEKLMTVFCGMLMNYSSENDSLQTQLIQMGVIPILVDLLGVHSQNTALTEMCLVAFGNLAELESSKEQFAGTNIAEEIVKLFKKQTEHEKREIIFEVLAPLAENDAIKMQLVEAGLVECLLDVVQQTVNSEKDDDIAELKTSSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWLPSNNHQLQLAGALAIANFARNDGNCIHMVDSEIVQKLLDLLDRHVEDGNVTVQHAALSALRNLAIPVVNKAKMLSAGVAEEVLKFLRSEMPPVQFKLLGTLRMLIDAQAEAAEQIGKNEKLAERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIRTIVQSGGIKHLVTMATSEHVIMQNEALVALGLIAALELQAAEHDLESAKLVEVLHRLLLDERSAPEIKYNSMVLICAAMGSVPLHKEVQKLAFLDVVSKLRSHENKTVAQQASLTEQKLTVQS
Protein: AMP-dependent synthetase/ligase domain-containing protein (Q584V5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 50S ribosomal protein L13, putative
- Large ribosomal subunit protein uL3m
- Peptidyl-prolyl cis-trans isomerase
- KOW domain-containing protein
- 50S ribosomal protein L17, putative
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
- Uncharacterized protein
- Ribosomal protein L9 domain-containing protein
- Large ribosomal subunit protein bL21m
- C2H2-type domain-containing protein
Sequence:
MLRRLAGCVAFRKNVVRPFMNSTALLSSSPAAVSAPVIPKSSNEGKDYSVASGSVDTPVLDQLVGYYVNIQSRKMYYKDFLRIEHQAVRWAFADIRKNSEALAHGLLQTGLRPGQRVLAIQPCNCETFVLQLACAKIGALLAVVPHHNISADKLRFYLNEFQPHHLIAREWIVVPEVKQGVLVERNMHFWDMIYNVIPELGLSYPGQRFQWVHSQEFFFLKKVVITDHNMNLLGVTPMRKMLVWGPFSYYEQRLRRLSALLHPDDPILALEDPHPALEDKLHITYSHRNCINAGFLFGNLMGLKAESRFGVMPNHHVDPVGAIVAPYAALTTGAVLVHIHSDMFTDDHAINGIEKLCVEEVVGMLGKKSDFDLLLRHAGNFDADQYEHLKWVVLFEDASEPTVGDEYLQKLAKELGLEDVFVFRGPLESAYMVMWRSLKRARWEMVPHVEAKVVGDRGTADARILAANTRGNLKLKGPHISAGYYNNAGLLTELVDERGFCSTSREAVMDERGQLTLHGTQLY
Protein: Homeobox protein Nkx-2.1 (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP) (P50220)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1.
Subcellular location: Nucleus {ECO:0000269|PubMed:22955271}.
Interaction partners:
- Paired box protein Pax-8
- Transcription factor GATA-6
- Pulmonary surfactant-associated protein B
- Mothers against decapentaplegic homolog 3
- Hepatocyte nuclear factor 3-alpha
- LIM/homeobox protein Lhx6
- Thyrotropin receptor
- Surfactant protein C
- Hepatocyte nuclear factor 3-beta
- Forkhead box protein E1
Sequence:
MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQSHAQQQAQQQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAGLQGQVSSLSHLNSSGSDYGAMSCSTLLYGRTW
Protein: Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) (Q9CX86)
Organism: Mus musculus (Mouse)
Function: mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.
Subcellular location: Nucleus {ECO:0000250}. Note=Component of ribonucleosomes. {ECO:0000250}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein K
- Serine/arginine-rich splicing factor 1
- Heterogeneous nuclear ribonucleoprotein U
- Serine/arginine-rich splicing factor 3
- Serine/arginine-rich splicing factor 2
- Heterogeneous nuclear ribonucleoprotein M
- Heterogeneous nuclear ribonucleoprotein Q
- ELAV-like protein 1
- Heterogeneous nuclear ribonucleoprotein U-like protein 2
- Heterogeneous nuclear ribonucleoproteins C1/C2
Sequence:
MENSQLCKLFIGGLNVQTSESGLRGHFEAFGTLTDCVVVVNPQTKRSRCFGFVTYSNVEEADAAMAASPHAVDGNTVELKRAVSREDSARPGAHAKVKKLFVGGLKGDVAEGDLIEHFSQFGAVEKAEIIADKQSGKKRGFGFVYFQSHDAADKAAVVKFHPIQGHRVEVKKAVPKEDIHAGGGGARAARGGRGGGRGRGGGGGGGGRDQNGLAKGGGGGGGGYNSYGGYGGYGAYGGGGGGGGSYGGSDYGNGFGGFGSYSQHQSSYGPMKSGGGGGGGGSWGGRSNSGPYRGGYGGGYGGGSF
Protein: Tripeptidyl-peptidase sed2 (EC 3.4.14.10) (Sedolisin-B) (Q70J59)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:16517617}.
Interaction partners:
- Probable dipeptidyl peptidase 4
Sequence:
MFSSLLNRGALLAVVSLLSSSVAAEVFEKLSAVPQGWKYSHTPSDRDPIRLQIALKQHDVEGFETALLEMSDPYHPNYGKHFQTHEEMKRMLLPTQEAVESVRGWLESAGISDIEEDADWIKFRTTVGVANDLLDADFKWYVNEVGHVERLRTLAYSLPQSVASHVNMVQPTTRFGQIKPNRATMRGRPVQVDADILSAAVQAGDTSTCDQVITPQCLKDLYNIGDYKADPNGGSKVAFASFLEEYARYDDLAKFEEKLAPYAIGQNFSVIQYNGGLNDQNSASDSGEANLDLQYIVGVSSPIPVTEFSTGGRGLLIPDLSQPDPNDNSNEPYLEFLQNVLKMDQDKLPQVISTSYGEDEQTIPEKYARSVCNLYAQLGSRGVSVIFSSGDSGVGAACLTNDGTNRTHFPPQFPAACPWVTSVGGTTKTQPEEAVYFSSGGFSDLWERPSWQDSAVKRYLKKLGPRYKGLYNPKGRAFPDVAAQAENYAVFDKGVLHQFDGTSCSAPAFSAIVALLNDARLRAHKPVMGFLNPWLYSKASKGFNDIVKGGSKGCDGRNRFGGTPNGSPVVPYASWNATDGWDPATGLGTPDFGKLLSLAMRR
Protein: Pheromone receptor transcription activator (Protein map1) (P78926)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: In response to mating-pheromone signaling or nitrogen starvation, it interacts with mat1-Pc. This activates the expression of one of two mating-type-specific genes sxa2 or map3, which leads to inactivation of the P-factor. May also interact with mat1-Mc.
Subcellular location: Nucleus.
Interaction partners:
- Serine/threonine-protein kinase sck1
- Serine/threonine-protein kinase sck2
Sequence:
MMDERKLSNFQIDGEKAYTGSSQGNSYLEDRQKRQNTFTKRKAGIFKKANELALLTGSEVMVLVVSETGLVHTFSTPKLENVVKSPEGQKLITESLINATTDQNESQASQAKQSSAQLSDSESGYPLDHEEMRISEENGPSHIENLNFFSDIDNFSKTSAEEIASKLFSSVSPTHETLQFDHGLQNLEGFQANEHPEMFADHSIDFYNSNNVDIPALSMLTSQTSSSSTLNLPPEPASREVKIFPKQGKRIFSPSTGIDYETTGQHSVNSPPSTYKHRRSLNKSFATRSEPQTPRKNKIRDSLQSSPLNFPPRDRPPLIPISRIAVPSTIETEERQYRGNQKIINFYAKIFEPNSGLGTSSEGASSSFPDVDPNLAQNGVPYYSLPDIDHNQFDHLRR
Protein: Metallo-beta-lactamase superfamily protein,putative (P71840)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Protein Rv0786c
- Phosphoribosylformylglycinamidine synthase subunit PurS
- Phosphoribosylformylglycinamidine synthase subunit PurQ
Sequence:
MHRPPWLAQLRRRLRIGVQLGSRVVLEQGRQPRDVYVIGVLVGDQDRGQTGDSLEAVRESTGIEEQAGLTELSEEAGMAEMRELHVYDCALMGAFPMRLILATMLVAGRLLATLMAAPSAQAEPETCPPICDQIPATAWISTHAVPLNSQYRWPAMAGAAVAVTRATPRFGFEQVCATPAFPHDSRDWAVAGRVTVVHPDGQWQLQAQVLHWRGDTARGGQIAASVFGTAVAALRACQLGAPLQSPSVTDDEPTRMAAVISGPVIMYTYLVAHVSSSTISELTLWSSGPPQVPWPTVADSAVLDALTAPLCEAYIGSCP
Protein: Small ribosomal subunit protein mS23 (37S ribosomal protein S25, mitochondrial) (O42911)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein mS47
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein mS45
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS10m
Sequence:
MPKFNANGLLRSFAAEMKKPWTAESLWYETVAKHPPTFQYARRIVPLYDPNKVKSRGKRLRKSMYQPQEIQWPEDKLRKRFYRDHPWELARPQIIAENDGNDQQYCDWSHMDQPRKALSGESVVQRTLWLIENSNMPVENAYDQARKEFYHLRAEQEIQQRVAHDQAQALGAVFTKSDLELGYEMDQNALNSWFDNASQYAEANRTKFTDPSVDISKTTQ