wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q38BV9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTPKCTKQSINRKRGQGTSGLKASALVATADQGDPPPFSPSLELTFRGHRSTVLAASFRPTAVSYSYSSLDGRGSPENVWSSPCILSGGADGYVFMWSARPTVRALRFVGPHSPVRDCAWSSHGQLLASAGHDGFVRLWLPMLRRTSGLTGSSSSGGGCVGSGGENCYLWRAHEGPVRALAAAPYDDYLYTAGDDKSVKCWDLNYSPTRSSSSGKSGGHKFVCGFVGGHQNWVRTVAVSNGMSALPSHGPLVASGGDDRTVQVWDPRSRRPTHTFYEHTDSVRSVDFHPDGCSIATGSSDHTINVYDLRLNRLLQHYGAHDGAVNEVRFAPTGSWLLSASADGTAKLWDLKEGYLYCTLSAHEGGVYTSRFSDDSRHLVTAGQDGLVMMWRTGLLRTQPVYATHFYAGKCPPVGAATEPLPLPAATSINTEPRPEDGFDHTHLADSTVVNREGRRCGSRDAKELGTCLARSRRNSTDVVSGHRTSEGKRPNVGVAKSKLGNRATFSVASSQNSAVSSQRPPLAQPSLQAGGSAAAAAMAVSAEIDDCPFAACLRNDVCNGVGSGNSIAQSFSRSERRERTPVKPKTETHNGSEEFSVPNEAFHTVSMKVSVSDGGHQQGEENQRRLQPQERHHPLPTNAQVTSAVGVEGSLRGNTSGVGEEDEEMCVVEYIDDASGEARYNGWMNCAESASHHVDHSMLSRKGDEHNMNARLERLEKAYARLAEEVQVSQRHTVEVVQKQQENWELQRQQQRAEMEQLRVMMAGLVAQQDALLEALRKA
Protein: Monoterpene synthase like 1, chloroplastic (PbTPS-mono1) (EC 4.2.3.-) (R9QMR2)
Organism: Pinus banksiana (Jack pine) (Pinus divaricata)
Function: Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MALVSAVPLDSRLCLCRTLFGLTHELKAIRRTIPNLGMCRGGKSIAPSMSMSSTTFVSSEDGVPRRIGGHHSNLWDDDSIDSLSTSYEAPSYRERADRLIGEVKDMFHLISVEDGVSTSPLNDLHHRLWMVDSVERLGIDRHFKNETNAALDHVYSYWTEKGIGRGRESGATDLNSTALGLRTLRLHGYMVSSHVLDHFKNEKGQFACSAIQTDGEIRDVLNLFRASLIAFPGEKIMEEAEMFSTMFLKDALQKIPPSGLSQEIEYLLEFGWHTNLPRMETRMYIDVFGEDTTFETPYLIRERLLELAKLEFNIFHSLVKRELQSLSRWWKDYGFPEITFSRHRHVEYYTLAACIANDPKHSAFRLGFAKICHMVTILDDIYDTFGTMEELELLTAAFKRWDPSSIECLPDYMKGVYMAVYDNINETAREAQKIQGWDIVSYARKSWEALFDAHMQEARWISSGYLPTFEEYLENGKVSFGSRLTTLEPMLTLGFPLSPRILQEIDFPSNFNELICAILRLRGDTQCYKADMARGEEASSVSCYMKDHPGITEEDAVNQINALVNNLTKELNWELLRPDSGVPISYKKFYFDIWRVFHYGYKYRDGFSVASIEIKNLVTRTVVETVPL
Protein: Myelin protein zero-like protein 3 (Q3V3F6)
Organism: Mus musculus (Mouse)
Function: Mediates homophilic cell-cell adhesion.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MQLARGTVGGRGCALFPLLSILVVQGARIVLSLEISADAHVRGYVGEKIKLKCTFKSSSDVTDKLTIDWTYRPPSSSRTESIFHYQSFQYPTTAGTFRDRISWAGNVYKGDASISISNPTLKDNGTFSCAVKNPPDVYHNIPLTELTVTERGFGTMLSSVALLSILVFVPSAVVVILLLVRMGRKATGVQKRSRSGYKKSSIEVSDDTDQEDSNDCMTRLCVRCAECLDSDYEEEAY
Protein: DUF2510 domain-containing protein (O06345)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MEHDVATSPPAGWYTDPDGSAGQRYWDGDRWTRHRRPNPSAPRSPLALRVDGLRSRWLGMPAGLRLTVPVAAVLTMVGVAVYAWIRPLPDDWSQLPKRLSCQLRPGPTPPATITVASVDVSHPRGAVLRLVVRFAEPLPPSPSGSFASGFAGYLLTYTIANNGKEFAELGPQQDTDELAIRKPGESRGTEPNMRPDRNTNARRTAPDTVEINLETKRLGLDQAPVDPQLTFAAQFRTPSTVTVDFGSQFCQGERLAGQRR
Protein: Sin3A-associated protein 130, isoform A (Q9XZ09)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSAPSEGGAGGGPVGGGSTATAPSAHPAVAAKITHVKSDGGGGISIAGTPILSGGTIKVASANQVQQTSLGGTPIALNAGQATTAASIRAIGAGGQSTQVRVVMPMIKQLENVTATGRTQITAIPAAPARSGANASITVTRPVTQATYLPRASVTATQMGGVGVGVGQRLVTPLRATSSATVTPTAPTVLSSTGGFVRGATASVSRSGVALTSQPSSAVISSSNSGAWMQSQGQVQLIRTIHQPRQRIITTSAGVSNASVVTTTPVQAPTALSVSAGQPLATQQATGPGGGPQAYVATVLPQRQHQATLVYSSNVSAPNASQNPGQQFNPRFAVATPTGGVTTTTPGGTTVTPRQVRPIPLGKSFPTAKLNTTSISIRAPSIPQLNTSVTASPTAVSVSGGATVAPGRGPGAGGTALTATNLPTTRIIQLQQPATGTTQQIIGSGARLAGNVMLQPFLMSTTAAAKMGIRPPVTMTAKVQPSLTITQLNPIGKLSAGGGSGGQTMGPQGVASIQAVPVPNVSASVVNSSSVTGATSAAGGATVLPLTISGRGAGVGPGGNILTGTLTPIKNASGITLGKMMMAPASSAPGADGSSTSGATVTGFQRTWNPVVASQSQLMKIDEKGSAATIYYESMPASASTGVLSLTTTTVTQSTQAQAQLVSSAGGSLSVSSLPFASHATAGAGSGGGGSQATFTVLPSGAGGTATRTIGHQQLIIPAGPNSAPPQHMVIPLHTSVKVTTGAGNPQQATASGALVSSFMRKRDAEGSPIRAAKNLGPTLLSMASNNSGQNMPPAPGTTFNIQPVSVTVPQSVGSGLTVEALAKKERERVTHGVASSAASVPATVGPVNSTRNSRADSPASSDGSTTVSANSSPGVDQQLQDRIGDQPATGGAGGRDNSTHFNPINEMYSSHQSIQQNLGHSSLGARSGSSAFVDVQAPTPQQQQPQQVPHLVGSTQMQQGTRMNGTGNSSSSSYDCSSRKKPRRSTNDSQHSTQSQASLSLPPPSSEPTPPAGASYMQKHNNGGLLVTAATPGVAPNSAPGDANHRNSTPAVAGNKENANPVDFVIRRPRNCALLNTYKPTHKLANNHFHRYTDVKPREERRATVIDLANQPNVQGKINGWKIYHLRSQMEDLNESEVFSLGRLETMLQDLEKDKEKHSEIERVTELLKGNIQRSKIITDGINEAQNQLMKIFEHKPHVSNIITRCASKRNFKKREKI
Protein: Chloroplast protein import component Toc159 (Q9LKR1)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000256|ARBA:ARBA00023766}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00023766}.
Interaction partners:
Sequence:
MDSQTLSSSSQFHEPNNLLNGVNGHGSDSDSDDGFVSGEDEAEPSTPILVYDAKSTVQVKEKEEESFDQESPRPIAKVTADDEDEAEEEEDDSQGVGLEKEGGGGGGKDVEEVKEDEVFVEANDKGFESVDSEGGDVVGEEINNGLREEGDGGTEIETVRSDSVVVEPVSVDNSGVGVVENGDGVVDNEKLTSGGDFVVDSLRVNPLVDGGVAVVGDEVKDEVSEIDGAVAPAPVASLDNSFEAIEKVGSRSVVDEVGSSFETIEKGDEVVVDDEVVGGDVEPSKVVDSGVEIEVDDNVAHEQLSDVVLTEKAGDVVVDENVGVGAKPDEVVDIGVDEGVAQRQVSDIAPAEKGEEISEVVSQSLEAAEDEINIENRVVEGGIESRVVEGGIESRVDDAVEGEVGSNVVEVEDGSNVDNVAEKDAVSNVDDAAEKDAVSNVDRVVEVEDESHVGNTVEGEARSNADHVLQVEDETHLDNAAVGEAKSNADRVVEVEDETPLDNAAVGEAESNVDPAVKVEDDTRFDNGAEGEAESNVDRVGEVEDDTHFDNAVEEEAESNVDRVVEVEDDTHFDNAVEEEADSNVDRVIEMDDGSHVEAAVDHHIDREIDDLLSDSKDESMIFGGSDSANKYLEELEKQIRDSESSQGDRIDGQIVTDSDEEDVSDEEGGSKELFDTATLAALLKAASGAGGEDGGGITLTAQDGSRLFSVERPAGLGPSLQTGKPAVRSIRPNLFAPSMSRAGTVVSDTDLSEEDKKKLEKLQEIRIKYLRVIQRLGFTTEESIAAQVLYRLTLVAGRQIGEMFSLDAAKESASRLEAEGRDDFAFSLNILVLGKTGVGKSATINSIFGETKTSFSAYGPATTSVTEIVGMVDGVEIRVFDTPGLKSSAFEQSYNRKVLSTVKKLTKKSPPDIVLYVDRLDLQTRDMNDLPMLRSVTSALGPTIWRNVIVTLTHAASAPPDGPSGSPLSYDVFVAQRSHIVQQAIGQAVGDLRLMNPNLMNPVSLVENHPSCRKNRDGQKVLPNGQSWKPLLLLLCYSMKILSEATNISKTQEAADNRRLFGFRSRAPPLPYLLSWLLQSRAHPKLPDQAGIDNGDSDIEMADLSDSDGEEGEDEYDQLPPFKPLKKSQIAKLNGEQRKAYLEEYDYRVKLLQKKQWREELKRMRDMKKRGKNGENDYMEEDEENGSPAAVPVPLPDMVLPQSFDSDNPAYRYRFLEPNSQLLTRPVLDTHSWDHDCGYDGVNIENSMAIINKFPAAVTVQVTKDKQDFSIHLDSSVAAKHGENGSTMAGFDIQNIGKQLAYIVRGETKFKNFKRNKTAAGVSVTFLGENVSTGVKLEDQIALGKRLVLVGSTGTVRSQNDSAYGANVEVRLREADFPVGQDQSSLSLSLVQWRGDLALGANFQSQISLGRSYKMAVRAGLNNKLSGQINVRTSSSDQLQIALIAILPVAKAIYKNFWPGVTENYSIY
Protein: Uncharacterized protein (Q38BC9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTSATSISEADNPPHTYAAPGEEAVALINRRLARIHDAVEELRRTEDIETAEFQNFSARMDEEETTIRCLMDELDATKEELVEQAEHENLRLRTSELSERIQRLLWTEACLSLMEQHTMERVNTLWGHFSGGIVGVKGSGWDRQSVRLFNHPTQLQGSHPSLEESLGVRCNETLCAPVRKFAPLSPECERLMAVIRSSSCDSETVSEVLAQFGDSGSHIVNKADEEGNTALHVLCGKHNFSTAVLKLLLKAGADASAKNAQGRSPFHIACLNTSDGAAQLKRALLGAGCDVNERTDDGETAAHMCATDDRHFDSLQFLCSVDADLSAGAFFQGVWCTPIKVAQLSGERALRTLEYLKLC
Protein: LHFPL tetraspan subfamily member 4 protein (GABAA receptor regulatory Lhfpl4) (Lipoma HMGIC fusion partner-like 4 protein) (Q7Z7J7)
Organism: Homo sapiens (Human)
Function: Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs.
Subcellular location: Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TSY2}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q5U4E0}; Multi-pass membrane protein {ECO:0000255}. Note=Specifically localizes to inhibitory postsynaptic sites (By similarity). Colocalizes with GPHN, GABRG2 and NLGN2 at inhibitory postsynaptic sites (By similarity). {ECO:0000250|UniProtKB:Q5U4E0, ECO:0000250|UniProtKB:Q7TSY2}.
Interaction partners:
- Neuroligin-2
- Gephyrin
Sequence:
MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILAIIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVLPCPVAHSQGP
Protein: Mitochondrial 10-formyltetrahydrofolate dehydrogenase (Mitochondrial 10-FTHFDH) (mtFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2) (Q3SY69)
Organism: Homo sapiens (Human)
Function: Mitochondrial 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:20498374}.
Interaction partners:
- C-1-tetrahydrofolate synthase, cytoplasmic
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
- Serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
- Dihydrofolate reductase
- Cytosolic 10-formyltetrahydrofolate dehydrogenase
- Dihydrofolate reductase 2, mitochondrial
- Methionine synthase
- Trifunctional purine biosynthetic protein adenosine-3
Sequence:
MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGKADPLALAAEKDGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGEPLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVPIIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGEDQEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLEY
Protein: CheY protein (Chemotaxis response regulator) (Q53134)
Organism: Cereibacter sphaeroides (Rhodobacter sphaeroides)
Interaction partners:
Sequence:
MPLTVLAIDDSRTIRELLREALVQAGFEVHLAIDGLDGLEKLEAAKPHAVITDINMPRMDGFGFIRAVREQPQHSALPIIVLTTESAAELKAKAREAGATAWIVKPFDEAKLVSALRRVAVA
Protein: Trafficking protein particle complex subunit (Q8I1Q2)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus, cis-Golgi network {ECO:0000256|ARBA:ARBA00004222, ECO:0000256|PIRNR:PIRNR018293}.
Interaction partners:
- Trafficking protein particle complex subunit 6A, putative
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 8, putative
- Trafficking protein particle complex subunit 2-like protein, putative
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 2, putative
- Ras-related protein Rab-1A
- Tetratricopeptide repeat protein
- Ras-related protein Rab-1B
Sequence:
MSKDKYQKQGDAIFAKLEKVNSELFSFTYGALVSQLLKDLELVDEVNEQLEKMGFNIGTRLIEEFLAKSDISFCEDFEETVNVIAKVAFKMFLGISGTVTCVNKESNIFSIIFDNNPLSDFVELPKSLSSLNYCSLLCGVIKGALEQIRIKVNCYFVKDMLKGDDYYELYIQLNEVMKEEILNDEES
Protein: Radial spoke head protein 3 homolog (A-kinase anchor protein RSPH3) (Radial spoke head-like protein 2) (Q86UC2)
Organism: Homo sapiens (Human)
Function: Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:27120127}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000305}.
Interaction partners:
- N-acylneuraminate-9-phosphatase
- Protein phosphatase 1 regulatory subunit 21
- Inhibitor of growth protein 3
- Pre-mRNA-splicing regulator WTAP
- Radial spoke head protein 6 homolog A
- Radial spoke head protein 4 homolog A
- Radial spoke head protein 9 homolog
- Dystrobrevin alpha
- Dystrobrevin beta
- T-cell activation Rho GTPase-activating protein
Sequence:
MTVKPAKAASLARNLAKRRRTYLGGAAGRSQEPEVPCAAVLPGKPGDRNCPEFPPPDRTLGCWATDAAPAAGLCGAGSEPSIAPTSCAGNLPSRPPPLLSPLLASRNPCPWHYLHLSGSHNTLAPTCFKAKLHRKRGSQPPDMASALTDRTSRAPSTYTYTSRPRALPCQRSRYRDSLTQPDEEPMHYGNIMYDRRVIRGNTYALQTGPLLGRPDSLELQRQREARKRALARKQAQEQLRPQTPEPVEGRKHVDVQTELYLEEIADRIIEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILEGELFDFDLEVKPVLEVLVGKTIEQSLLEVMEEEELANLRASQREYEELRNSERAEVQRLEEQERRHREEKERRKKQQWEIMHKHNETSQKIAARAFAQRYLADLLPSVFGSLRDSGYFYDPIERDIEIGFLPWLMNEVEKTMEYSMVGRTVLDMLIREVVEKRLCMYEHGEDTHQSPEPEDEPGGPGAMTESLEASEFLEQSMSQTRELLLDGGYLQRTTYDRRSSQERKFMEERELLGQDEETAMRKSLGEEELS
Protein: Ninjurin-1 (Nerve injury-induced protein 1) (A0A0R4IDX9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis (By similarity). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal region (By similarity). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (By similarity). Acts as a mediator of both programmed and necrotic cell death (By similarity). Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Acts as a regulator of angiogenesis (By similarity). Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Also involved in striated muscle growth and differentiation.
Subcellular location: [Ninjurin-1]: Cell membrane {ECO:0000250|UniProtKB:Q92982}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q92982}. Synaptic cell membrane {ECO:0000250|UniProtKB:O70131}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASEAMELNGGVNRRDDPGARPQQGRMSRNTPLNMNHYANKKSAAESMLDIALLMANASQLKTVLELGPSFSFYIPLITLISISLTLQIIVGILLIFIVKWNLNDSSKHYILNLLENIVTALVFIVVVVNVFITAFGVQRPDDKTS
Protein: Cell division cycle protein 16, putative (Q584U1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cyclosome subunit 1, putative
- Cdc23 domain-containing protein
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 2
- Rev7, putative
- Ubiquitin-conjugating enzyme E2, putative
- Uncharacterized protein
- E2 ubiquitin-conjugating enzyme
- Anaphase-promoting complex subunit 10
- Non-specific serine/threonine protein kinase
Sequence:
MELSAVLESNAQRFLETEQPLNAVPLTAMLREVNPTSVKFSLLHATTLLAARDYDQAFRIAADVAKDFEGNMQAVAIAMKSAYELGDVRGCSAYAERLKDSPSMNVVALCYLGRCAELSGDTKRAVHNYCAALDIDPFCGEPMNALIERRLLGVNELRDTIESLRLPPEAEALRASYYARLPGEFVPKEFDKYIPRTTLLLQAARTEYERNDLQQALSLTTSLLKISPFNRECVCLHLSILVDMKATSKLFDVAHLLCSSKPHAELAVYAVGCFHFSLSNYERAGRFFTRATELDASFAEAWIAYGHCYAKLEEGEQALIVYRRAMNFFPGLPCCSTFVGMQYGRAHQWRLASHFLEEAKKAMPNDPLVLNEIGVLYMRTQRVDKAREMLEEAYKSLVNPENASEHRDCIIFNLATVYRKLQCYKQAIAFYTLYVKCRPSASHGHCALAFTHHLMGDMKMAIAHYHTALSIKADSFCRDMLDRALATEFGEASHGFAKRIEESLCSPSPDDISFLAASRTLRSDPTATSSKDHSHHPSVGRSLFFSA
Protein: Dolichyl-phosphate-mannose--protein mannosyltransferase 1 (Protein mannosyltransferase 1) (EC 2.4.1.109) (O74189)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of the cell wall proteins KRE9, PIR2, RHD3, and ALS1, as well as the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for filamentation and early phases of biofilm formation.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33775}.
Interaction partners:
Sequence:
MAKKPVTPASKVAAKQAAVRSRHQEDVFTLDPLIDPIFQKGELRSYLVTEPSPSVLKKRSIHTKEYWMLSSLLLIAFYVRMYNLSNPNSVVFDEVHFGGFARKYILGTFFMDVHPPLAKMLFGAVGAIGGFKGDFEFKSIGDKFPDSTPYIFMRQFPALLGVGTVILCYLTLRQSGVRPIIAYITTFLLIIENSNVTISRYILLDSPLIFFIAAAIYAWKKFEIQIPFTFGWYRSLLATGIALGLALSSKWVGLFTVAWVGFLCIYQLWFLIGDLSVSTKKIWGHFFARGIILLGVPIALYLGFFAIHFQLLNKEGDGGAFMSSAFRAGLQGNKIPRDITEQVGLGSVVTIRHVDTQGGYLHSHEHFYQTGSKQQQITLYPHLDSNNKWLIEPYNGTIHNETFVPLINGMKIRLKHINTGRRLHSHDEKPPVSERDWQKECSCYGYDGFAGDANDDWVVEIVNYRSQKGEAQTFVKAINTIFRLRHAMTGHYLFSSEVKLPEWGFGQQEVTSASQGKRALTHWYIETNENSILPPSEAKIINYPKLSLWQKVVESHKRMWKINQGLTSHHHWQSSPSEWPLLLRGINYWNKEHKQVYLLGNAVTWWAATLSIITFGTYVLVTVFRWHLGTPLSTNKHVFNFNVQTFSYVLGWALHYLPFFIMGRQLFLHHYLPALYFGILALGHFFEIFTGYLTSRSKYFQQVAFVLVGLFSILSLVFYVNYSSLIYGTPWTKASCELTKPFSGWDYNCGTFFDTLGEYDIQEKSLASESEIPTETVVVEAKQTPKAEPKLAKQDDHIESPAAAEPVEEKEVKEEVEQLAPPLAVDFEEETPKVEDPQVADVDASSNDEKSVEEKQQQEQQQEQEQVEDESVHQVQQ
Protein: SH3 domain protein, conserved (Q388D2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- BRCT domain-containing protein
- BTB domain-containing protein
- GTP binding protein
- Small GTPase, putative
- FUN14 family
- Heat shock protein 83
- Heat shock protein, mitochondrial, putative
- SH3 domain-containing protein
- Uncharacterized protein
- 14-3-3-like protein, putative
Sequence:
MYGGYGAGMPSMYGSGMSSMYGGYGAGMPSMYGTGMSSMYGGYGGGMSSVYGGLGGGMSSMYGGGLSSMSGTYGGMGMNGILGNPVGGAIGGNGMNGALALPGDQAGGGLLPSQPDQQQPLQFAKPLATETRRERRARRRQEKEAVERHRQQKKQLAIHSTIEVVGHVLQILFQLMRSGLELFGVGFGTYYSIKALKSIVKSQEGAVPKGISGAAVAKAAELAPSGSSAPPAGGRWKSWVLRVALFILMEILYRAHLRYRNWTARQSLRRKDSDLTLSEEDDELQDELSESEDCSSEEEWSDETVEATARSSNRHDAQHCNGGRVYVAMFDYVSPEKEGFIGFKTGDRFIVDDYTENGWCQATTATDDKKLERKGLVPGNFLRLLERETKL
Protein: Negative elongation factor E (P92204)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing.
Subcellular location: Nucleus {ECO:0000269|PubMed:12782658}. Chromosome {ECO:0000269|PubMed:12782658}. Note=Associates with polytene chromosomes. Associates with the hsp70 promoter when it is inactive, but not when it is activated. The NELF complex possibly dissociates from chromatin following phosphorylation of RNA polymerase II.
Interaction partners:
- Negative elongation factor B
- Negative elongation factor D
- Negative elongation factor A
- Transcription elongation factor SPT5
- Transcription elongation factor SPT4
- Nuclear cap-binding protein subunit 2
- DNA-directed RNA polymerase II subunit RPB3
- Cyclin-dependent kinase 9
- Nuclear cap-binding protein subunit 1
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MVYIHFPNNLTEEEQMLQAKYQKLKKKKKALQAHKAPKPEPESSLTLKRPTDARDAREVARKLIKSGAIPAIQKQTKQDQTSFKRPKGQERAKRSTSETTVASYQPFSSTQNDVAQETIISEIIKEEPRRQNLYQHFATERDREERGMPEKVPMDTAQPEKPRAGNTIFVSGNKVTEDFLKKTFNDYGTIVNVSMEIEKSRGFVSFAKPESADRAIAEIHGKNVNGINLQVQLARRQPQIEPINDASSSAVWSSIAASKSQKGSHKDHREMVQYDEDFLL
Protein: Dehydrogenase (Q7MBY8)
Organism: Vibrio vulnificus (strain YJ016)
Interaction partners:
- NADH:flavin oxidoreductase
- Glutaredoxin 2
Sequence:
MMGSDKTVYVVLGGTSGIGAELAKQLESEHTIVHVASRQTGLDISDEKSVYHYFETIGAFDHLIVTAGSYAPAGKVVDVEVTQAKYAFDTKFWGAVLAAKHGARYLKQGGSITLTSGMLSRKVVANTYVKAAINAAIEATTKVLAKELAPIRVNAISPGLTKTEAYKGMNADDRDAMYQRTQSHLPVGKVGEASDIAMAYLFAIQNSYMTGTVIDVDGGALLG
Protein: Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase) (Q969G6)
Organism: Homo sapiens (Human)
Function: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- FAD synthase
- Tumor necrosis factor receptor superfamily member 1A
- Tartrate-resistant acid phosphatase type 5
- Flavin reductase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Cytochrome b-245 light chain
- Iodotyrosine deiodinase 1
- NADPH oxidase 1
Sequence:
MRHLPYFCRGQVVRGFGRGSKQLGIPTANFPEQVVDNLPADISTGIYYGWASVGSGDVHKMVVSIGWNPYYKNTKKSMETHIMHTFKEDFYGEILNVAIVGYLRPEKNFDSLESLISAIQGDIEEAKKRLELPEHLKIKEDNFFQVSKSKIMNGH
Protein: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) (Q9Y765)
Organism: Candida albicans (Yeast)
Function: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
Interaction partners:
Sequence:
MTDSKYDYSDITPVDINTEEPQICQILYDEDYKQIMGLLLALMKAEEYSERALHITELGINELASHYTIWIYRFNILKNLPNRNLYDELDWCEEIALDNEKNYQIWNYRQLIIGQIMELNNNDFDPYREFPILEAMLSSDPKNHHVWSYRKWLVDTFDLHNDAKELSFVDKVIDTDLKNNSAWSHRFFLLFSKKHLATDNTIDEELNYVKDKIVKCPQNPSTWNYLLGIHERFDRSITQLEEFSLQFVDLEKDQVTSSFALETLAKIYTQQKKYNESRTVYDLLKSKYDPIRSNFWDYQISKLTSV
Protein: Paired-like homeodomain transcription factor LEUTX (Leucine-twenty homeobox) (Paired-like homeobox transcription factor LEUTX) (PRD-LIKE homeobox transcription factor LEUTX) (A8MZ59)
Organism: Homo sapiens (Human)
Function: Paired-like homeobox transcription factor involved in embryogenesis. May act as a regulator of embryo genome activation. Binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos.
Subcellular location: Nucleus {ECO:0000269|PubMed:27578796}.
Interaction partners:
- Divergent paired-related homeobox
- KHDC1-like protein
- Methyl-CpG-binding domain protein 3-like 2
- Tetra-peptide repeat homeobox protein 1
- Double homeobox protein 4-like protein 2
- Tripartite motif-containing protein 43
- Double homeobox protein A
- Double homeobox protein B
- PRAME family member 2
- Methyl-CpG-binding domain protein 3-like 3
Sequence:
MFEGPRRYRRPRTRFLSKQLTALRELLEKTMHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWKRQQRQQMQTRPSLGPANQTTSVKKEETPSAITTANIRPVSPGISDANDHDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV
Protein: Granulin b precursor (Progranulin-b) (Q7T3M4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MVRAAFIALLCVCVNACTALICPDGGMCEDENTCCLTPSGGYGCCPLPHAECCSDHLHCCYQGTLCDLEHSKCVNKTHVLDWVEKVEAKLQAVVCPDGESECPDDTTCCQMPDGGWGCCPMKNAVCCDDRKHCCPQGTTCDLVHSMCVSATYGSSPFLRKFAARRRKPLEKNAVDLPAEVNNIREVICPDKISKCPEDTTCCLLETGSYGCCPMPKAVCCSDQKHCCPEGTTCDLIHSTCLSANGVSEMAIKIPAVTVLKPKEEVVPCNETVACSSGTTCCKTPEGSWACCPLPKAVCCEDHIHCCPEGTLCNVAASSCDDPTELSVSVPWMEKVSTKPIAPPPNKKCDESSSCPGESTCCKLSSGDWGCCPLPEAVCCEDHVHCCPHGSVCNVAAETCETVSDSALRISVPMVKKIPAVSVPSQKQNCDETSSCPTGTTCCKLTSGSWACCPVPQAVCCADQEHCCPQGYTCDLAQSSCVRSGLPSMAWFRKEPALRETQRVEDRHMCDAHTSCPRDDTCCFINRIGKWGCCPLPKAVCCKDGDHCCPSGYTCNEEKTSCTKGLHQIPWFTKKTARVWKSSDELLGHEDVKCDSSTSCPSGSTCCILPTGQWGCCPLVKAVCCEDHEHCCPQGYICKLELGTCEKASADLSVSLTAVQMPEIQCDTFTRCAHTQSCCRLADSTWACCPYTQAVCCKDMKHCCPMGYKCDPKVQGCTKSSSSTWWNNSL