wanglab/gogpt-training-data huggingface dataset:
Protein: Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) (Q9HB58)
Organism: Homo sapiens (Human)
Function: Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00185, ECO:0000255|PROSITE-ProRule:PRU00747, ECO:0000269|PubMed:10913195, ECO:0000269|PubMed:25593309}. Note=Found in the nuclear body. {ECO:0000269|PubMed:10913195}.
Interaction partners:
- Nuclear autoantigen Sp-100
- XIAP-associated factor 1
- Antiviral innate immune response receptor RIG-I
- Interferon-induced 35 kDa protein
- Sterile alpha motif domain-containing protein 9-like
- Protein mono-ADP-ribosyltransferase PARP9
- 2'-5'-oligoadenylate synthase 1
- Interferon-induced protein with tetratricopeptide repeats 3
- 2'-5'-oligoadenylate synthase 2
- Signal transducer and activator of transcription 1-alpha/beta
Sequence:
MFTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFEGLLDNSIITKRMYMESLEACRNLIPVSRVVHNILTQLERTFNLSLLVTLFSQINLREYPNLVTIYRSFKRVGASYEWQSRDTPILLEAPTGLAEGSSLHTPLALPPPQPPQPSCSPCAPRVSEPGTSSQQSDEILSESPSPSDPVLPLPALIQEGRSTSVTNDKLTSKMNAEEDSEEMPSLLTSTVQVASDNLIPQIRDKEDPQEMPHSPLGSMPEIRDNSPEPNDPEEPQEVSSTPSDKKGKKRKRCIWSTPKRRHKKKSLPGGTASSRHGIQKKLKRVDQVPQKKDDSTCNSTVETRAQKARTECARKSRSEEIIDGTSEMNEGKRSQKTPSTPRRVTQGAASPGHGIQEKLQVVDKVTQRKDDSTWNSEVMMRVQKARTKCARKSRLKEKKKEKDICSSSKRRFQKNIHRRGKPKSDTVDFHCSKLPVTCGEAKGILYKKKMKHGSSVKCIRNEDGTWLTPNEFEVEGKGRNAKNWKRNIRCEGMTLGELLKRKNSDECEVCCQGGQLLCCGTCPRVFHEDCHIPPVEAKRMLWSCTFCRMKRSSGSQQCHHVSKTLERQMQPQDQLIRDYGEPFQEAMWLDLVKERLITEMYTVAWFVRDMRLMFRNHKTFYKASDFGQVGLDLEAEFEKDLKDVLGFHEANDGGFWTLP
Protein: FI16531p1 (Male-specific transcript 36Fb) (E1JHL3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glycerol-3-phosphate dehydrogenase
- Protein dpy-30 homolog
- Don juan like
Sequence:
MVSKKRKNSDENKKKVETTFESDPYEIKFPLPEQLDPSQCRDEFIGTFIREHELRASSLRPRSTFRAASEFRSSQDLSDQGPEKGAEAMVVRQLVSQRKRLSLRKTKEEILENIKLRSTMMNDLNLKCQKAAIEFLSVRLLKQLRLFSSPWPGDTGDIPYNLFSWSMDDFLMRLAIKQVYLDVIHRERSAEDLDCLKFCKDLGQIELLIYEIREDYRNDRDLCQGSMELLRSAQYNINAPWVSTLKDNLESIRSSTLTARLFAQSSAFNIVLRHSSAMGAFEDESAQDPIEMRYQINWIRSCTDQRLYRINGREEKMRKELNDLEVQALQDEKVRNSSELIYSLEVGKLRESVRVWQERLDTDLENAEVTCTVSKLALQKVKDDIKFYKEQKDMYLQRIEEVQAIIAQEQGVFGSTRSRLSRKSVRNSERKSERMSEKKSERNSENKIGRKSERLSERRSERKSRNSKMP
Protein: Frizzled-3 (dFz3) (O77438)
Organism: Drosophila melanogaster (Fruit fly)
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Axin
- Vang-like protein
- Segment polarity protein dishevelled
- Protein wingless
- Low-density lipoprotein receptor-related protein
- Protein Wnt-5
- Protein prickle
- Protein espinas
- Wnt inhibitor of Dorsal protein
- Diego, isoform A
Sequence:
MYAASILILHLTWAVATIAANGAGHNGPVASGAGPNGLQCQPIAVSACQGLGYNMTALPNLAGHTNQLEAELQIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAPPELMELWPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGASPTSDLAGVLCPQNFSGSPFNPEECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLERIVFHNQARMHDVELQGRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTGMCYAPGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLAHHRFGQIRKRFVLFSLLYFAPTTAGVVAALCERYADSVPSCSTPDDCLSPTPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRNRLGASGTPTSSLMNQSKAAGALPKKHLYTSGKSMLPTGGITPLYAGISFHNVPVYNPNQSRV
Protein: 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (OsG6PGH2) (EC 1.1.1.44) (Q2R480)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Subcellular location: Plastid, chloroplast {ECO:0000250}.
Interaction partners:
- Glucose-6-phosphate 1-dehydrogenase
- Ribulose-phosphate 3-epimerase, chloroplastic
- Ribulose-phosphate 3-epimerase, cytoplasmic isoform
- Glucose-6-phosphate 1-dehydrogenase
- Glucose-6-phosphate 1-dehydrogenase
- Os01g0926300 protein
- Os08g0154300 protein.
- Glucose-6-phosphate 1-dehydrogenase
- Glucose-6-phosphate 1-dehydrogenase
- Probable 6-phosphogluconolactonase 4, chloroplastic
Sequence:
MASPAPAPPAASSSAAGSAPPPRIGLAGLATMGQNLALNIAEKGFPISVYNRTAAKVDATVSRAEAEGALPVLGHRDPRGFVLSLSRPRTVVLLVQAGRAVDATIDALVPYLDAGDAIVDGGNEWYQNTERRIEEAAARGILYLGMGVSGGEEGARNGPSLMPGGHIDAYNNIRDILEKAAAQTEDGACVTFVGPGGAGNFVKMVHNGIEYGDMQLIAEAYDVLRRVGGLSNSEIADVFAEWNRGELESFLVEITADIFTVADPLDGSGGGGLVDKILDKTGMKGTGKWTVQQAAELAIAAPTIAASLDGRYLSGLKDERVAAAGVLEAEGMPSGLLETINVDKKMLVDRVRQALYASKICSYAQGMNLLRAKSVEKGWNLNLAELARIWKGGCIIRAKFLDRIKKAYDRNPELANLIVDREFAREMVQRQNAWRWVVARAVEAGISTPGMSASLSYFDTYRCSRLPANLIQAQRDLFGAHTYERIDRPGSFHTEWTKLARKSNGAAI
Protein: EF-hand domain-containing protein (Q4QIT3)
Organism: Leishmania major
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}. Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Interaction partners:
- Calcium uniporter protein C-terminal domain-containing protein
- Calcium uniporter protein C-terminal domain-containing protein
- Calcium uniporter protein C-terminal domain-containing protein
- Prohibitin
Sequence:
MTVVLCRSYETPTYLIPYYLRDVRSRFLHYASVRKRKGGPMYMTVEDFVLALLASPEKVLPNPDIVQDLQRLFESMDANGDGYISFPEFRFLMSLLTSDPHEVEALFSIVSTDNSGTLSLEEFANVLRGATKDEGVVRSLLKPSTRRNGIVRALFGDETAPRRCSFRELEALIHSVRTEVWKAEFRQYDVEKHNRITAEEFAALIARQVLGSHLPYYLVGNIRRLHGSGDVVTLDMWLGLNEVMLYAEQLAANVEMFSGSGMSVTKRDFPRLMSMAGVPALPQATIDIIFAVFDKNGDGSMEMDELLFIMRKKVKYHYSAPPHERKSLPKRFLECSSDVLAGLGR
Protein: Inhibin beta B chain (Activin beta-B chain) (Q04999)
Organism: Mus musculus (Mouse)
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subcellular location: Secreted.
Interaction partners:
- Inhibin beta A chain
- Follistatin
- Activin receptor type-2A
- Activin receptor type-2B
- Activin receptor type-1B
- Activin receptor type-1C
- Activin receptor type-1
- Bone morphogenetic protein receptor type-1B
- Bone morphogenetic protein receptor type-1A
- Inhibin alpha chain
Sequence:
MDGLPGRALGAACLLLLVAGWLGPEAWGSPTPPPSPAAPPPPPPPGAPGGSQDTCTSCGGGGGGFRRPEELGRVDGDFLEAVKRHILSRLQLRGRPNITHAVPKAAMVTALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAETDGLASSRVRLYFFVSNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVKVYFQEQGHGDRWNVVEKKVDLKRSGWHTFPITEAIQALFERGERRLNLDVQCDSCQELAVVPVFVDPGEESHRPFVVVQARLGDSRHRIRKRGLECDGRTSLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGPVNSCCIPTKLSSMSMLYFDDEYNIVKRDVPNMIVEECGCA
Protein: peptidylprolyl isomerase (EC 5.2.1.8) (Q8ISE5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTVNKRDAGATRPRCFFDISLGGLGMGRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKLQYKGVIFHRVVKDFMVQAGDFSAGNGTGGESIYGGTFEDESFEKKHDRPFLLSMANRGKNTNGSQFFITTQPAPHLDNIHVVFGQVISGQELVRQLEGLPVDRNSRPLQDAAIANCGELVRQTKAKKEKKHKRRSTATEDSNSEESEAEAKVVRKAKKKKRSRKDTKSESDSEDNETSRGNGKHDQTTQDDDEDREEGELHPLVTITKIDPNEIPEVSNKFLMRAERSKSLDREERGARGQDRDRGKDQDRSRNNFGWSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRSRSTTPPHWKHAQKRTIKLSDLERIEEESKMREEEMKRREHERKRRHEEATKNPKQSFFELSHASTYGGKITPDRFSPEHKAKSKDTADRGKAKEREKAGEKDKARDVTPVKRRKSMDMNALDYEQQTESEVESEDEEQLKVKPPSKQDIRVEPSTSKDRNAKRDERKPTEEKAKPKRSRSRSPRRQSPARRQQRSPARRPGQNYNQNQNQNQNQNQNQNQLNRGNRRNPFADRDRRRRSRSQDNEYRNRYPLSPIRGRGSPSGDRRRQQRSRSQNRRQDSPSQRRQLSPGRKRQDSPSKKRPNSTERKWRDSPERKRDDSHDRKREASPNWKRDDSPARKRKDSANRKREDSQDKKIQDSKRQEDSAGKKREDSPSKKRKDSDKKRQDSPVKRQESPGRKRQDSPERKRRDSPDRRRKDSPARRRQESSGRRRQDSDGRRRRESSGNRRSRSRGRWHSSSRSRSPSTSRSRRRRSRSPLPKLTSALPMSEEREKAAREKMQKRAEAAMLMKEHMRNEIAKEEERRMEKQRQDDLDKERTTRELNELERLKAETLRKLHEEDSVDPDAAASAGSASKTDATSTGAKSKRDSSSENRHREKKRKHKKSKKSSGRSDND
Protein: Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) (A0A494C1T8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
Protein: Mf4 protein (Myofilin, isoform L) (Myofilin, isoform M) (Q70VI1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFKNHLEMIGRNESPSKKAKFWQSYIRSLKGSEDIRAHEAPRASRPYSSYLDSPSYRSIYDEPATANERVQSSGYRYLPVSRDTYGYSPRAIYDHHYSRTIPANYDAEKAWNDHLKRMQEIERRYPSRYGLYLRDKPLTPNSLVPLEYEPEDKLLAELNKARRSASPFRPARTTRAGSEPYVPPPSYWNREGSVPRGGPSVFDRATSLAPFTRPSFRASSLEPLDELFERKLPAIAEADSAPADAPSRPLGIFERAGSPSPTPVKAGRWGPRPTEVAYDAEGLPIFHPRNRFRDLLSPSPNLPISSIVRDPFWWDVDDLVPFRATSVPRASSPVARDSYLSPVKNRYLWSKHPARPLTPHRSIL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q57V67)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAQVADECKALSSELFLSKYRIMKGIGKGSFGEAVLVRSKEDGKRYVAKAIESAAMSAKEKRDVQNEIRILAAANHPNIIRYHEHFEDGTLIFIVMEYADGGDLNTRIKDAKKNDPVVPFEPKLAMFWFLQICMALKYLHDNHILHRDLKTANIFLTAKNVVKLGDFGISTVVQNTLACAKTVCGTPYYFSPELCQNKPYNNKSDVWALGVILYELLTLQRPFLARSLKELLKKILVGQYEPIPSTVPAEIRGLCGALLQVNPVQRPSINRILESPFVQESLKGFSADLEKQAEKERAEYEARNPKITKPVKPVSTPEKPKEYPKEPQLSQKEQMAKLRGMNRESIKAMLAEQAAAGPPQEQQQQSPSKSEQDDGHHEVDDDGEYIEQKKLIVEQSKNIVGKTNLGGHPEEFGDGPSDSSPQEDMIILSSGKSVPASQVRAILEKEIGVKLLNEAAELVNQLMLNNEISNVDIQKQLNELLGAQHAHHSNAITKLCVYEGKKM
Protein: Nodal (P43021)
Organism: Mus musculus (Mouse)
Function: Essential for mesoderm formation and axial patterning during embryonic development.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Activin receptor type-1B
- Left-right determination factor 2
- Left-right determination factor 1
- Activin receptor type-2A
- Activin receptor type-2B
- Activin receptor type-1C
- Teratocarcinoma-derived growth factor
- Embryonic growth/differentiation factor 1
- Inhibin beta A chain
- Inhibin beta C chain
Sequence:
MSAHSLRILLLQACWALLHPRAPTAAALPLWTRGQPSSPSPLAYMLSLYRDPLPRADIIRSLQAQDVDVTGQNWTFTFDFSFLSQEEDLVWAELRLQLPGPMDIPTEGPLTIDIFHQAKGDPERDPADCLERIWMETFTVIPSQVTFASGSTVLEVTKPLSKWLKDPRALEKQVSSRAEKCWHQPYTPPVPVASTNVLMLYSNRPQEQRQLGGATLLWEAESSWRAQEGQLSVERGGWGRRQRRHHLPDRSQLCRRVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLEHHKDMIVEECGCL
Protein: DNA repair nuclease/redox regulator APEX1 (APEN) (REF-1) (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (Apurinic-apyrimidinic endonuclease 1) (Redox factor-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] (G3V5Q1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus {ECO:0000256|RuleBase:RU362131}. Cytoplasm {ECO:0000256|RuleBase:RU362131}. Mitochondrion {ECO:0000256|RuleBase:RU362131}.
Interaction partners:
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMM
Protein: Uncharacterized protein (Q35963)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MYSIFDLLFEDFHFSFSSLLSDSPPHSTDVFPSNLLLLSYHSSPRSSRPTGSSSFRRAKLLSEPLRAGSGVGCVHSAGAESQHPSGGHTWAAEALPNGRKDIQC
Protein: Protein-serine/threonine kinase (EC 2.7.11.-) (F1NLP2)
Organism: Gallus gallus (Chicken)
Subcellular location: Mitochondrion matrix {ECO:0000256|RuleBase:RU366032}.
Interaction partners:
- Acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
- L-lactate dehydrogenase A chain
Sequence:
MRLLRALLRCASPGSIPQQVDFYSRFSPSPLSMKQFLDFGSENACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYVQSLQEILDFKDKSSEDSGAIHSFTDTVIKIRNRHNDVIPTMAQGVIEYKESFGIDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKINPAHPKHIGSIDPSCNVVGVIRDGYESAKSLCDLYYMSSPELVLEELNIKSPGQPMQVVYVPSHLYHMVFELFKNAMRATMEHNADRCIYPPIHVHVTLGNEDLTVKMSDRGGGVPMRKIDRLFNYMYSTAPRPRVETSRATPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESIERLPVYNKAAWKHYKANHEADDWCVPSSEPKDMTTFRST
Protein: Protein BIM1 (P40013)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds microtubules.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Karyogamy protein KAR9
- Protein STU2
- Nuclear fusion protein BIK1
- Tubulin alpha-1 chain
- Tubulin beta chain
- Kinesin-like protein KAR3
- Tubulin alpha-3 chain
- Kinesin-like protein KIP2
- Kinesin-like protein KIP3
- Aurora kinase
Sequence:
MSAGIGESRTELLTWLNGLLNLNYKKIEECGTGAAYCQIMDSIYGDLPMNRVKFNATAEYEFQTNYKILQSCFSRHGIEKTVYVDKLIRCKFQDNLEFLQWLKKHWIRHKDESVYDPDARRKYRPIITNNSATKPRTVSNPTTAKRSSSTGTGSAMSGGLATRHSSLGINGSRKTSVTQGQLVAIQAELTKSQETIGSLNEEIEQYKGTVSTLEIEREFYFNKLRDIEILVHTTQDLINEGVYKFNDETITGHGNGNGGALLRFVKKVESILYATAEGFEMNDGEDELNDKNLGEHGTVPNQGGYANSNGEVNGNEGSNHDVIMQNDEGEVGVSNNLIIDEETF
Protein: Claudin-12 (P56749)
Organism: Homo sapiens (Human)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular location: Cell junction, tight junction. Cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Claudin-3
- Claudin-4
- Claudin-2
- Claudin-8
- Claudin-1
- Claudin-5
- Claudin-7
- Tight junction protein 1
- Claudin-17
- Claudin-15
Sequence:
MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYVTIASAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHTYSQPYSARSRLSAIEIDIPVVSHTT
Protein: Expressed protein (Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family) (Q9SJV8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MPPPPSSSRAGLNGDPIAAQNQQPYYRSYSSSSSASLKGCCCCLFLLFAFLALLVLAVVLIVILAVKPKKPQFDLQQVAVVYMGISNPSAVLDPTTASLSLTIRMLFTAVNPNKVGIRYGESSFTVMYKGMPLGRATVPGFYQDAHSTKNVEATISVDRVNLMQAHAADLVRDASLNDRVELTVRGDVGAKIRVMNFDSPGVQVSVNCGIGISPRKQALIYKQCGFDGLSV
Protein: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35) (P35913)
Organism: Homo sapiens (Human)
Function: Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP. Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal.
Subcellular location: Membrane; Lipid-anchor. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:20940301}.
Interaction partners:
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
- Guanine nucleotide-binding protein G
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
- Guanine nucleotide-binding protein G
- Peripherin-2
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Cyclic nucleotide-gated channel alpha-1
- Retinal guanylyl cyclase 1
- Protein RD3
Sequence:
MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYVLHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL
Protein: Ig-like domain-containing protein (A0A4W8)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MLLSRLLPLLWVLKWASGNCFILPREVIGTYPSLTLELQSVTVQEGLCVLVPCHLIEYPMNRWSDAAFGYWFHEGENTHPDSLVATNKPYQLVQKEMQSRFHFSGDCSLDIRDAQKGDNGSYFFRLEKGGKTWNFCEERISVHVTDLTHSPNISIPQTLELGRPTNVMCSVPWACERGTPPIFSWMSAALISLGPTTTLSSVLTLTPRLQDHGTNLTCQVTFPGAGVTVQKTIQIDVTWKPRPLADVVQVAMGEAAIKFLLLGICFFFLSKRSHTKRVERPATHMDQAHAVMD
Protein: Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor) (P79763)
Organism: Gallus gallus (Chicken)
Function: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P23945}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23945}.
Interaction partners:
- Follitropin subunit beta
- Glycoprotein hormones alpha chain
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Aromatase
- TGF_BETA_2 domain-containing protein.
- Steroidogenic acute regulatory protein, mitochondrial
- Growth/differentiation factor 9
- TGF_BETA_2 domain-containing protein.
- 3Beta_HSD domain-containing protein.
Sequence:
MSLGLTCLLILLASCSGCQHHTCLCEGRIFICQEIKVVQLPRDIPTNATELRFVLTKMRVIPKGAFTGLHDLEKIEISQNDALEIIEGNVFSSLPKLHEIRIEKANKLMKIDQDAFQHLPSLRYLLISNTGLSFLPVVHKVHSFQKVLLDVQDNIHIRTIERNTFMGLSSESVILRLNKNGIQEIKDHAFNGTCLDELNLSDNYNLEKLPEKVFQGAIGPVVLDISRTRISFLPSHGLEFIKKLRARSTYKLKKLPDVNKFRSLIEANFTYPSHCCAFTNRKTQNTEFYPICSMSPAKQDLGEQTGKRKHRRSAAEDYISHYGTRFGPVENEFDYGLCNEVVDFVCSPKPDAFNPCEDIMGYNVLRVLIWFINILAITGNTTVLIILISSQYKLTVPRFLMCNLAFADLCIGIYLLFIASVDIQTKSRYYNYAIDWQTGAGCNAAGFFTVFASELSVYTLTVITLERWHTITYAMQLNRKVRLRHAVIIMVFGWMFAFTVALLPIFGISSYMKVSICLPMHIETPFSQAYVIFLLVLNVLAFVIICICYICIYFTVRNPNVISSNSDTKIAKRMAILIFTDFLCMAPISFFAISASLRVPLITVSKSKILLVLFYPINSCANPFLYAIFTKTFRRDFFILLSKFGCCEMQAQIYRTETSSSAHNFHTRNGHYPTASKNSDGTIYSLVPLNHLN
Protein: Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1) (Q8WUH2)
Organism: Homo sapiens (Human)
Function: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11278302}. Early endosome {ECO:0000269|PubMed:25266290}. Note=Colocalizes with TGF-beta receptors in the absence of signaling.
Interaction partners:
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting-associated protein 8 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein sorting-associated protein 33A
- Vam6/Vps39-like protein
- Vacuolar protein sorting-associated protein 33B
- Ras-related protein Rab-5A
- Charged multivesicular body protein 2a
Sequence:
MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKELFRSGQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKRFLMSYLNEVRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQDSTRSDLYEYIVDFLTYCLDEELVWAYADWVLQKSEEVGVQVFTKRPLDEQQKNSFNPDDIINCLKKYPKALVKYLEHLVIDKRLQKEEYHTHLAVLYLEEVLLQRASASGKGAEATETQAKLRRLLQKSDLYRVHFLLERLQGAGLPMESAILHGKLGEHEKALHILVHELQDFAAAEDYCLWCSEGRDPPHRQQLFHTLLAIYLHAGPTAHELAVAAVDLLNRHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHARRTMQVALGLARSENLIYTYDKMKLKGSSIQLSDKKLCQICQNPFCEPVFVRYPNGGLVHTHCAASRHTNPSSSSPGTRT
Protein: Calreticulin-3 (Protein PRIORITY IN SWEET LIFE 1) (O04153)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Required for elongation factor Tu receptor (EFR) accumulation and for EFR, but not flagellin-sensing 2 (FLS2) signaling.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:19717464}.
Interaction partners:
- Endoplasmin homolog
- UDP-glucose:glycoprotein glucosyltransferase
- Heat shock 70 kDa protein BIP3
- Calnexin homolog 1
- Calnexin homolog 2
- Calreticulin-2
- Calreticulin-1
- Heat shock 70 kDa protein BIP2
- Heat shock 70 kDa protein BIP1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Sequence:
MGLPQNKLSFFCFFFLVSVLTLAPLAFSEIFLEEHFEGGWKSRWVLSDWKRNEGKAGTFKHTAGKWPGDPDNKGIQTYNDAKHYAISAKIPEFSNKNRTLVVQYSVKIEQDIECGGAYIKLLSGYVNQKQFGGDTPYSLMFGPDICGTQTKKLHVIVSYQGQNYPIKKDLQCETDKLNHFYTFILRPDASYSVLVDNKEREFGSMYTDWDILPPRKIKVKNAKKPEDWDDREYIDDPNDVKPEGFDSIPREIPDRKAKEPEDWDEEENGLWEPPKIPNSAYKGPWKAKRIKNPNYKGKWKNPWIDNPEFEDDPDLYVLKSIKYAGIEVWQVKAGSIFDNILICDDPAYARSIVDDYFAQHRESEKELFAEAEKERKAREDEEARIAREEGERRRKERDHRYGDRRRRYKRPNPRDYMDDYHDEL
Protein: Dynamin associated protein 160, isoform G (M9PBF6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNSAVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINEFSIACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPVVPVVAPPVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLPGQTSFEDKRKENYVKGQAELDRRRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKDKVENISKEIESKKEDINTNDVQMSELKAELSALITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTGSSSAWEETGTTVTDPYAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKLEVGEVAPVAAVEAPVDAQVATVADTYNDNINTSSIPAASADLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQKADVGTASTAAAEPVESLDQETTLNGNAAYTAAPVEAQEQVYQPLPVQEPSEQPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEPAESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTSGNV