wanglab/gogpt-training-data huggingface dataset:
Protein: Inverted formin-2 (Q0GNC1)
Organism: Mus musculus (Mouse)
Function: Severs actin filaments and accelerates their polymerization and depolymerization.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}.
Interaction partners:
- Alpha-actinin-4
- Nephrin
- Podocin
- Dynamin-1-like protein
- CD2-associated protein
- Short transient receptor potential channel 6
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Sequence:
MSVKEGAQRKWAALKEKLGPQDSDPTEANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHALTLDALDHYKMVCSQQYRFSVIMSELSDSDNVPYVVTLLSVINAIILGPEDLRSRAQLRSEFIGLQLLDILTRLRDLEDADLLIQLEAFEEAKAEDEEELQRISDGINMNSHQEVFASLFHKVSCSPASAQLLSVLQGLMHLEPAGRSGQLLWEALENLVNRAVLLASDAQACTLEEVVERLLSIKGRPRPSPLDKAHKSVQTNSVQNQGSSSQNTTTPTTKVEGQQPVVASPCQHVGSIQSSSVDIAPQPVALEQCITALPLPTPPLSSSTPVLPPTPPPLPGPGATSPLPPPPPPLPPPLPGSGTTSPPPPPPPPPPLPPPLPGSGTISPPPPPPPPPLPGTGAVSPPPPPPLPSLPDSHKTQPPPPPPPPLPGMCPVPPPPPLPRAGQIPPPPPLPGFSVPSMMGGVEEIIVAQVDHSLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVARERNSMWATLGSPCTAAVEPDFSSIEQLFSFPTAKPKEPSAAPARKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTSMIQAGDTSKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLSNADQFYVLLLDIPCYPLRVECMMLCEGTAIVLDMVRPKAQLVLTACESLLTSQRLPVFCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEKSHPDLLQLSRDLEPPSQAAGINVEIIHSEASANLKKLLEAERKVSASIPEVQKQYAERLQASIEASQELDKVFDAIEQKKLELADYLCEDPQQLSLEDTFSTMKTFRDLFTRALKENKDRKEQMAKAERRKQQLAEEEARRPRDEDGKPIRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTEASGRVAPTDPPKATEPATASNPTQGTNHPASEPLDTTAADEPQGWDLVDAVTPSPQPSKEEDGPPALERRSSWYVDAIDFLDPEDTPDAQPSEGVWPVTLGDGQALNPLEFSSNKPPGVKSSHQDATDPEALWGVHQTEADSTSEGPEDEAQRGQSTHLPRTGPGEDEDGEDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVQGRVSKGTSKRRKKRPSRNQEEFVPDSDDIKAKRLCVIQ
Protein: ATP-dependent RNA helicase RhlE (EC 3.6.4.13) (Q9I689)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00968}.
Interaction partners:
- Polyribonucleotide nucleotidyltransferase
- Ribonuclease E
- Nucleotide-diphospho-sugar transferase
- Large ribosomal subunit protein uL3
- Bifunctional NAD
- Ribonuclease R
- Large ribosomal subunit protein uL4
- Ribosomal large subunit pseudouridine synthase C synthase)
- Large ribosomal subunit protein uL13
Sequence:
MSFSSLGLSEALARAVEAAGYSQPTPVQQRAIPAVLQGRDLMVAAQTGTGKTGGFALPVLERLFPAGHPDREHRHGPRQARVLVLTPTRELAAQVHDSFKVYARDLPLNSTCIFGGVGMNPQIQALAKGVDVLVACPGRLLDLAGQNKVDLSHVEILVLDEADRMLDMGFIHDVKKVLAKLPPKRQNLLFSATFSKDIVDLANKLLHNPERIEVTPPNTTVERIEQRVFRLPAPQKRALLAHLVTVGAWEQVLVFTRTKHGANRLAEYLTKHGLPAAAIHGNKSQNARTKALADFKANDVRILVATDIAARGLDIDQLPHVVNYELPNVEEDYVHRIGRTGRAGRSGEAISLVAPDEEKLLKAIEKMTRQRIPDGDAQGFDPEAVLPEVAQPEPREAPQKQPRRDKERRSSRERKPKDAQASNPDSNVAAAQDGTEKPAGKRRRRGGKNKENREAGQAQQPRQSREARPAKPNRPPEVDGNRDPEEFLDDDFDNFGNRADYVSPYQGQENKGRGRRGGQQKPQGGTGQQGRGQGQGQARGKSQGAAQGGARGQGAGQGKAKKPRAGKPRGQGRENASRMSDAPLREPSEYGTGKQPSRQPVVINKRDLVRMDRFPTAEQLDELEPRRKGERPALLTRNR
Protein: Glutamate receptor-interacting protein 2a (B0V3R3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Syntabulin
- Kinesin-like protein
- Tripartite motif-containing 36.
- FRAS1-related extracellular matrix protein 3 precursor
- Glutamate receptor
- Glutamate receptor, ionotropic, AMPA 2a.
- FRAS1-related extracellular matrix 2a
- Kinesin-like protein
Sequence:
MFPPLLSALLELARKFRVQRSCQRQWDSSENYTNALPAFQKTPSAWSQTTPTPSHRSVSSGVSANTSGFHSYNCGSQSAYPNTYPSSTLPSYPSSPRCSATKRRHRRKEHKSSLSLASSTVGAGGQVVHLESAEVLLRGDPLTGFGLQLQGGVFATEPLSAPAAIRFIEPDTPAERCGVLQVGDRILSINGIPTEDGTLEEANQLLRDAALANKIALEVEFDVAESVIPSSGTFQVKLPKRRGVELGITISASKKAGKPLIISEIQKGSIAHRIGTLEPGDRLLAIDNVRLDNCGMEEAMMVLQQAEGMVKLRIQKDEDNLDELESSGSVIFTVELKRHGGPLGITISGTEEPFNPILISSLTRNGLAHRTGALHIGDRVLAINNMSLKGKPLSEAIHLLQTAGDTVTLKIKKRSDPLLDSERGSPSRTASCVSDMEDDRSDSFRRGKYSDLLRQTTPPSLDSAMDSWDSSALDAGYGSQGVYIHRPSDFTLHPSDWRQTNHRSPLMSRRPAHRPTVYDGRLSEEDWTYSGSVSPACGHNYNSTTDAQENYWSQALQDLETCGQSEILRELEATIMSGSTLSLGEDFEKQNESKTKFLELSPENTSVNTPEDLKENSPSVPLELHKICIQKDADSRDFGFSVSDGLLEKGVYVNMIRPDGPADQAGLRPYDRILQVNHARTRDFDCCLAVPLITEAGENLQLVISRNPLAQAHDWPPKDCQDTSQQSAQNPRKVDL
Protein: Annexin (Q5T3N1)
Organism: Homo sapiens (Human)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004187}. Cell membrane {ECO:0000256|ARBA:ARBA00004296}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004296}; Extracellular side {ECO:0000256|ARBA:ARBA00004296}. Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Cell projection, phagocytic cup {ECO:0000256|ARBA:ARBA00004231}. Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004284}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000256|ARBA:ARBA00004263}. Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004481}. Lateral cell membrane {ECO:0000256|ARBA:ARBA00004124}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
Interaction partners:
Sequence:
MNLILRYTFSKMAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFG
Protein: Protein-glucosylgalactosylhydroxylysine glucosidase (E7EMA9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEDAGEDPTTFAAHSLPSDPRLLATVTNAYLGTRVFHDTLHVSGVYNGAGGDTHRAMLPSPLNVRLEAPAGMGEQLTETFALDTNTGSFLHTLEGPRFRASQCIYAHRTLPHVLAFRVSIARLAPGSGPITLLLRSAFSPESPDLDLHQGPDFQGARYLYGHTLTPEQPGGPQQEVHMLWTPAPPDLTLGEGEEARTWDFLTAVGGSQAEAQACLTEALQLQARGALYTAHAQAWAQLWVECGLDVVGPLQLRQALRGSLYYLLSALPQPKAPGYICHGLSPGGLSNGSREECYWGHVFWDQDLWMFPSILMFHPEAARAILEYRIRTLDGALENAQNLGYQGAKFAWESADSGLEVCPEDIYGVQEVHVNGAVVLAFELYYHTTQDLQLFREAGGWDVVRAVAEFWCSRVEWSPREEKHLTCASPTLTTGVEGRPLRLCTEHHLGLVCPGVMSPDEYHSGVNNSVYTNVLVQNSLRFAAALAQDLGLPIPSQWLAVADKIKVPFDVEQNFHPEFDGYEPGEVVKQADVVLLGYPVPFSLSPDVRRKNLEIYEAVTSPQGPAMTWSMFAVGWMELKDAVRARGLLDRSFANMAEPFKVWTENADGSGAVNFLTGMGGFLQAVVFGCTGFRVTRAGVTFDPVCLSGISRVSVSGIFYQGNKLNFSFSEDSVTVEVTARAGPWAPHLEAELWPSQSRLSLLPGHKVSFPRSAGRIQMSPPKLPGSSSSEFPGRTFSDVRDPLQSPLWVTLGSSSPTESLTVDPASE
Protein: Ras-related protein RABA2b (AtRABA2b) (Q9LNW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intracellular vesicle trafficking and protein transport.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18239134}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:18239134}; Lipid-anchor {ECO:0000305|PubMed:18239134}. Note=During cytokinesis located to the growing margins of the cell plate.
Interaction partners:
- Kinesin-like protein KIN-14E
- RING-type E3 ubiquitin transferase
- Protein C2-DOMAIN ABA-RELATED 10
- Geranylgeranyl transferase type-2 subunit beta 1
Sequence:
MANRIDHEYDYLFKIVLIGDSGVGKSNILSRFTRNEFCLESKSTIGVEFATRTLQVEGKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDITKRQTFENVLRWLRELRDHADSNIVIMMAGNKSDLNHLRSVADEDGRSLAEKEGLSFLETSALEATNIEKAFQTILSEIYHIISKKALAAQEAAGNLPGQGTAINISDSSATNRKGCCST
Protein: Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Q99KI0)
Organism: Mus musculus (Mouse)
Function: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P16276}.
Interaction partners:
- Citrate synthase, mitochondrial
- Isocitrate dehydrogenase subunit alpha, mitochondrial
- Citrate synthase
- Isocitrate dehydrogenase subunit
- Isocitrate dehydrogenase cytoplasmic
- Isocitrate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase subunit gamma 1, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- ATP-citrate synthase
Sequence:
MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPSEYIRYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRTDIANLAEEFKDHLVPDPGCQYDQVIEINLNELKPHINGPFTPDLAHPVADVGTVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPDADELPRSDFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPSDYNKIHPVDKLTIQGLKDFAPGKPLKCVIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
Protein: Histone deacetylase complex subunit SAP30 homolog (SIN3-associated polypeptide 30) (Q9VXB3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the class 1 Sin3A-histone deacetylase (HDAC1/Rpd3) complex (HDAC). Appears to be a non-essential subunit of this complex which is not required for cell cycle regulation of progression through the G2 phase of the cell cycle.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Histone deacetylase complex subunit SAP18
- FI07430p
- Paired amphipathic helix protein Sin3a
- Histone deacetylase HDAC1
- BRMS1 transcriptional repressor
- Protein deacetylase HDAC6
- Chromatin assembly factor 1 p55 subunit
- Inhibitor of growth protein
- Hat-trick, isoform D
- Sin3A-associated protein 130, isoform C
Sequence:
MNNGFSTGEEDSRGHTDQTCCLIDDMERCRNQAGYASYSKRIQKTVAQKRLKLSSDPAAQHIYICDHHKERIQSVRTKRRRKDSEDDSNETDTDLHEFPDLYQLGVSTLRRYKRHFKVQTRQGMKRAQLADTIMKHFKTIPIKEKEIITFFVYMVKMGSNKLDQKNGLGNDTT
Protein: Morf4 family associated protein 1 (A0A8L2R539)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRPLDAVELAEPEEVEVLEPEEDFEQFLLPVIHEMREDIASLTRERGRAPVRNRGKLWEMDNMLIQIKTQVEASEESALNHLQGAGGAEPRGPRAEKADEKAQEMAKMAEMLVQLVRRIEKSESSFPANGFWLSDGDWLT
Protein: G1/S-specific cyclin-D2 (Vin-1 proto-oncogene) (Q04827)
Organism: Rattus norvegicus (Rat)
Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P30279}. Cytoplasm {ECO:0000250|UniProtKB:P30279}. Nucleus membrane {ECO:0000250|UniProtKB:P30279}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250|UniProtKB:P30279}.
Interaction partners:
- cyclin-dependent kinase
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase inhibitor 1C
- Cyclin-dependent kinase inhibitor 1
- Retinoblastoma-like protein 2
- Retinoblastoma-associated protein
- Cyclin-dependent kinase 4 inhibitor C
- Cyclin-dependent kinase 4 inhibitor B
Sequence:
MELLCCEVDPVRRAVPDRNLLEDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKTHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSVKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQKEKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVNALTCDALTELLTKITHTDVDCLKACQEQIEAVLLNSLQQFRQEQHNGSKSVEDPDQATTPTDVRDVDL
Protein: Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase) (Q9V9S8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the ferrous insertion into protoporphyrin IX. Terminal enzyme in heme biosynthesis. Contains four conserved cysteines that function as cluster ligands and play a crucial role in maintaining protein structure.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22315}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22315}; Matrix side {ECO:0000250|UniProtKB:P22315}.
Interaction partners:
- Protoporphyrinogen oxidase
- Uroporphyrinogen decarboxylase
- Frataxin homolog, mitochondrial
- Protoheme IX farnesyltransferase, mitochondrial
- Heme oxygenase
- Holocytochrome c-type synthase
- Oxygen-dependent coproporphyrinogen-III oxidase
- hydroxymethylbilane synthase
- Delta-aminolevulinic acid dehydratase
- 5-aminolevulinate synthase
Sequence:
MFLHNTKFCRLASGLAGGVRNLSGQKPKTAILMLNMGGPTHTDQVHDYLLRIMTDRDMIQLPVQSRLGPWIAQRRTPEVQKKYKEIGGGSPILKWTELQGQLMCEQLDRISPETAPHKHYVGFRYVNPLTENTLAEIEKDKPERVVLFSQYPQYSCATSGSSFNSIFTHYRSNNLPSDIKWSIIDRWGTHPLLIKTFAQRIRDELAKFVETKRNDVVILFTAHSLPLKAVNRGDAYPSEIGASVHMVMQELGQTNPYSLAWQSKVGPLPWLAPATDDAIKGYVKQGLKNFILVPIAFVNEHIETLHELDIEYCDELAKEVGVEEIRRAATPNDHPLFIDALTNVVADHLKSQQAVNPKFLMRCPMCSNPKCRESKSWYRQLCSN
Protein: ATP-sensitive inward rectifier potassium channel 11 (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11) (Q61743)
Organism: Mus musculus (Mouse)
Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q14654}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14654}.
Interaction partners:
- ATP-binding cassette sub-family C member 9
- ATP-binding cassette sub-family C member 8
- ATP-sensitive inward rectifier potassium channel 8
- Gamma-aminobutyric acid type B receptor subunit 2
- Gamma-aminobutyric acid type B receptor subunit 1
- Rap guanine nucleotide exchange factor 4
- Hexokinase-4
- Insulin-2
- Insulin-1
- Rap guanine nucleotide exchange factor 3
Sequence:
MLSRKGIIPEEYVLTRLAEDPAEPRYRTRERRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNGIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS
Protein: Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) (Q9I235)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Tryptophan 2,3-dioxygenase
- Kynurenine formamidase
- Catalase A
- Catalase
- Catalase HPII
- Probable amino acid permease
- Anthranilate synthase component 1, pyocyanine specific
- Anthranilate synthase component 2
Sequence:
MTTRDDCLALDAGDPLADLRQLFALPDGVIYLDGNSLGARPRAAVERAAEVVAAEWGEGLIRSWNSADWRGLPERLGDKLAPLIGARAGEVVITDTTSINLFKVLSAALRIQEEDAPGRKVIVSESSNFPTDLYIAEGLTDMLQRGYRLRLVDDPEQLPAAIDADTAVVMLSHVNYKTGYLHDMREVTRLVHENGALAIWDLAHSAGALPLDLHAADADYAIGCTYKYLNGGPGSPAYVWVAPRLRERVWQPLSGWFGHSRQFAMEPRYQPGEGITRFLCGTQPITSLALVECGLDIFARTDMQRLRDKSLALADLFIELVESRCERFGLTLVTPREHARRGSHVSFEHAQGYAIVQALIDRGVIGDYREPGILRFGFTPLYTRFVEVWDAVQALLEILQSEAWKEPRYQVRHKVT
Protein: MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) (Q13368)
Organism: Homo sapiens (Human)
Function: Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:24503895}. Apical cell membrane {ECO:0000269|PubMed:16519681}. Cell junction, adherens junction {ECO:0000269|PubMed:16519681}. Note=Localized in apical villi of Mueller glia cells (By similarity). Localized at the apical membrane in the developing cortex and colocalized with apical proteins and adherens junction proteins (By similarity). Localized at the outer limiting membrane (OLM), and outer plexiform (OPL) of retina (PubMed:16519681). {ECO:0000250|UniProtKB:O88910, ECO:0000269|PubMed:16519681}.
Interaction partners:
- Protein lin-7 homolog C
- Cell adhesion molecule 1
- Protein lin-7 homolog A
- Cell adhesion molecule 3
- Glutamate receptor ionotropic, NMDA 2A
- Protein lin-7 homolog B
- Glutamate receptor ionotropic, NMDA 2B
- F-box/SPRY domain-containing protein 1
- Tyrosine-protein kinase Lck
Sequence:
MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVSWVR
Protein: Cellular retinoic acid binding protein I (B0FLN8)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKIGESFEEETVDGRKCRSLATWENENKIYCKQTLIEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE
Protein: Phosphomannomutase 2 (PMM 2) (EC 5.4.2.8) (Q9Z2M7)
Organism: Mus musculus (Mouse)
Function: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Mannose-6-phosphate isomerase
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- Mannose-1-phosphate guanylyltransferase regulatory subunit alpha
- Phosphomannomutase 1
- Hexokinase-1
- Hexokinase-3
- Hexokinase HKDC1
- Hexokinase-2
Sequence:
MATLCLFDMDGTLTAPRQKITEEMDGFLQKLRQKTKIGVVGGSDFEKLQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCKQNIQGHLGEDVIQDLINYCLSYIANIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKEHIRQKFVADLRKEFAGKGLTFSIGGQISIDVFPEGWDKRYCLRHLEHAGYKTIYFFGDKTMPGGNDHEIFTDPRTVGYTVTAPEDTRRICEGLFP
Protein: Alpha-2-HS-glycoprotein (Fetuin-A) (C9JV77)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLKLDGKFSVVYAKCDSSPADSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGGAEVAVTCMVFQTQPVSSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVLLAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPGRIRHFKV
Protein: DNA mismatch repair protein MLH1 (MutL protein homolog 1) (Post meiotic segregation protein 2) (P38920)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of different MutL heterodimers that form a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats, the repair of heteroduplex sites present in meiotic recombination intermediates, and the promotion of meiotic crossing-over.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA mismatch repair protein MSH3
- DNA mismatch repair protein MSH2
- DNA mismatch repair protein MSH6
- MutS protein homolog 5
- DNA mismatch repair protein PMS1
- DNA mismatch repair protein MLH3
- Exodeoxyribonuclease 1
- DNA mismatch repair protein MLH2
- ATP-dependent helicase SGS1
- MutS protein homolog 4
Sequence:
MSLRIKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGSGINKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAWRVSYAEGKMLESPKPVAGKDGTTILVEDLFFNIPSRLRALRSHNDEYSKILDVVGRYAIHSKDIGFSCKKFGDSNYSLSVKPSYTVQDRIRTVFNKSVASNLITFHISKVEDLNLESVDGKVCNLNFISKKSISPIFFINNRLVTCDLLRRALNSVYSNYLPKGNRPFIYLGIVIDPAAVDVNVHPTKREVRFLSQDEIIEKIANQLHAELSAIDTSRTFKASSISTNKPESLIPFNDTIESDRNRKSLRQAQVVENSYTTANSQLRKAKRQENKLVRIDASQAKITSFLSSSQQFNFEGSSTKRQLSEPKVTNVSHSQEAEKLTLNESEQPRDANTINDNDLKDQPKKKQKLGDYKVPSIADDEKNALPISKDGYIRVPKERVNVNLTSIKKLREKVDDSIHRELTDIFANLNYVGVVDEERRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDFANFGKINLQSTNVSDDIVLYNLLSEFDELNDDASKEKIISKIWDMSSMLNEYYSIELVNDGLDNDLKSVKLKSLPLLLKGYIPSLVKLPFFIYRLGKEVDWEDEQECLDGILREIALLYIPDMVPKVDTSDASLSEDEKAQFINRKEHISSLLEHVLFPCIKRRFLAPRHILKDVVEIANLPDLYKVFERC
Protein: Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Q9D1L0)
Organism: Mus musculus (Mouse)
Function: Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y6H1}. Mitochondrion {ECO:0000250|UniProtKB:Q9Y6H1}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9Y6H1}. Note=Mainly localized in the intermembrane space. {ECO:0000250|UniProtKB:Q9Y6H1}.
Interaction partners:
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- ATP synthase peripheral stalk subunit d, mitochondrial
- Cytochrome c oxidase subunit 8A, mitochondrial
- Cytochrome c oxidase subunit 6A1, mitochondrial
- ATP synthase peripheral stalk subunit F6, mitochondrial
- Parkinson disease protein 7 homolog
- MICOS complex subunit Mic25
- Vacuolar protein sorting-associated protein 35
- F-box only protein 7
Sequence:
MPRGSRSRTSRVTPPASRAPQMRAAPRRAPAAQPPAAAAPSAVGSPAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGGSAEPAKPDITYQEPQGAQLQNQQSFGPCSLEIKQFLECAQNQSDVKLCEGFNEVLRQCRIANGLM
Protein: NTPase, isoform C (EC 3.6.1.42, EC 3.6.1.6, EC 3.6.1.64) (NTPase, isoform D) (Q8IPZ6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDAVEIMDGTDEGIFSWFTVNFLLGRLSKTNQAAALDLGGGSTQVTFSPTDPDQVPVYDKYMHEVVTSSKKINVFTHSYLGLGLMAARHAVFTHGYKKEDTVLESVCVNPIIANRTWTYGNVQYKVSGKENGKSSAEQPIVDFDACLELVKSKVMPLVKPKPFTLKQHAVAAFSYYFERAIESGLVDPLAGGETTVEAYRKKAQEICAIPNDEQPFMCFDLTFISTLLREGFGLNDGKKIKLYKKIDGHEISWALGCAYNVLTSDEKFSNS