wanglab/gogpt-training-data huggingface dataset:
Protein: Two pore calcium channel protein 1 (Voltage-dependent calcium channel protein TPC1) (Q9EQJ0)
Organism: Mus musculus (Mouse)
Function: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis. Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (By similarity). Required for mTOR-dependent nutrient sensing.
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q9ULQ1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9ULQ1}. Endosome membrane {ECO:0000250|UniProtKB:Q9ULQ1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9ULQ1}. Early endosome membrane {ECO:0000269|PubMed:28855648}; Multi-pass membrane protein {ECO:0000269|PubMed:28855648}. Recycling endosome membrane {ECO:0000269|PubMed:28855648}; Multi-pass membrane protein {ECO:0000269|PubMed:28855648}.
Interaction partners:
- Two pore channel protein 2
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Sequence:
MAVSLDDDVPLILTLDEAESAPLPPSNSLGQEQLPSKNGGSHSIHNSQVPSLVSGADSPPSSPTGHNWEMNYQEAAIYLQEGQNNDKFFTHPKDARALAAYLFVHNHFFYMMELLTALLLLLLSLCESPAVPVLKLHTYVHATLELFALMVVVFELCMKLRWLGFHTFVRHKRTMVKTSVLVVQFIEAIVVLVRQTSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSTNPSDPYFSTLENSIVNLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKHKFKSLLLHKRTAIQHAYGLLASQRRPAGISYRQFEGLMRFYKPRMSARERFLTFKALNQSNTPLLSLKDFYDIYEVAALQWKAKRNRQHWFDELPRTAFLIFKGINILVNSKAFQYFMYLVVAVNGVWILVETFMLKGGNFTSKHVPWSYLVFLTIYGVELFMKVAGLGPVEYLSSGWNLFDFSVTAFAFLGLLALTLNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLTFYYSFAIVGMEFFNGRLTPNCCNTSTVADAYRFINHTVGNKTKVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKSQDSEVDSGIVIEKEMSKEELMAVLELYREERGTSSDVTRLLDTLSQMEKYQQNSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQKLRGSVPGPAAQQPPGSRQRSQTVT
Protein: Molybdenum cofactor sulfurase family protein (Similarity to unknown) (T19K24.17 protein) (O48588)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Nitrate reductase 1
- Nitrate reductase 2
- Peptide methionine sulfoxide reductase A2
- At1g21440
- Aspartate aminotransferase, cytoplasmic isozyme 2
- GDSL esterase/lipase At3g14220
- Inactive GDSL esterase/lipase-like protein 25
- AP2-like ethylene-responsive transcription factor At1g16060
Sequence:
MEEGLKIQSLVIYPIKSCRGISVPQATVTHTGFQWDRYWLVVNYKGRAYTQRVEPTLALVESELPKEAFLEDWEPTNDSLLVIRAPGMSPLKIPLTRPSSVAEGVSMWEWSGSAFDEGEEAAKWFSDYLGKQSRLVRFNKDTETRPSPPEFAAGYSTTFMDMFPFLVASQGSLDHLNTLLPEPVPINRFRPNILVDNCDPFGEDLWDEIKINDLVFQGVRLCSRCKVPTVNQETGVMGKAEPTETLMKFRSDNVLMPDKKPRGKVFFGKEMVWNWNLTNTEGEGKKTIKVGDTISVIRKIPSRAEAAV
Protein: Mitochondrial thiamine pyrophosphate carrier 1 (Q5A967)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004225}.
Interaction partners:
- Carnitine O-acetyltransferase, mitochondrial
- Carnitine O-acetyltransferase
- Peroxisomal hydratase-dehydrogenase-epimerase
- Carnitine O-acetyltransferase
Sequence:
MDDVDSALADNVKSFAAGGFGGICAVLTGHPFDLVKVRLQTGLYNSSVQCVKQTIAKDGLTGLYRGVLPPLLGVTPMFAVSFWGYDVGKRLVSTYTGKSIDQFEIKEISTAGFISAIPTTLVAAPFERVKVMMQIQEGNKSKSMAGVVAEMYKTGGLRSIFKGSVATLARDGPGSALYFATYEYLKKELSSPGEDLSLFAIMTAGGFAGVSMWLGVFPIDTIKSTQQSSNVPISILQTTKNIYAKGGIKAFFPGVGPALARSFPANAATFLGVELARKALDSII
Protein: Hair follicle protein AHF (Q80VU1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
EEQLRDRPFRREQERRLEREEEQLRDRPSRREQERHQEREEEQLRDRPSRREQERRLEREEEQLRDRSFRREQELRRDRKFHEEEERREELEEEQRGQERDRLRVEEQLRGQREEEQRRRQECDRKLHRELEVRQELEEERLRDRKLRREQELRRDRKFHEEEERRHEEFEEKQLRLQEPDRRFRREQELRQECVEEERLRDSKIRREQELRREREEERLRDRKIRRDQELRQGLEEEQLRRQELDRKFREEQELDQELEEERLRDRKIRREQELRREQELRREQEFRREQELRREQEFRREQELRQEREEERLRDRKIRRDQELRQGLEEEQQRH
Protein: AT5g62460/K19B1_7 (RING/FYVE/PHD zinc finger superfamily protein) (Q9FJJ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MADDQSSSTDRLVKPESLNSDRGSNQSIESSGESSRAQGSTSLSTTKSMDGKKTEEEETTEQRDVDDEEEPLIQSVECRICQEEDSVKNLESPCSCSGSLKYAHRKCVQRWCNEKGDTTCEICHKSYQPGYTAPPPPPADDTIIDIGEDWGNGVHLDLNDPRILAMAAAERHFFDADYDEYADSNSSGAAFCRSAALILMALLLLRHALNLTNNNSDDEEDDPSAFFFLFMLRAAGFLLPCYIMAWAISILQRRRQRQEAAALAAAEVAFMLHSGGGGGGQRRGGLHFAVPPELISNPHHQPEASPQ
Protein: tetrahydrofolate synthase (EC 6.3.2.17) (Tetrahydrofolylpolyglutamate synthase) (O53174)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ
Protein: Mitochondrial cox1 translation regulator ppr4 (O14275)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mitochondrial RNA-binding protein that specifically activates the translation of the cox1 mRNA.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:21727087}.
Interaction partners:
- Pentatricopeptide repeat-containing protein 6
- Protein mss51
- Uncharacterized protein C106.19
- Pentatricopeptide repeat-containing protein 5
- Mitochondrial 15S rRNA processing factor ppr3
- Cytochrome b
- DNA-directed RNA polymerase, mitochondrial
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 2
- Pentatricopeptide repeat-containing protein 7
Sequence:
MSKSFAYRHIWCFWRFNTPLLWFPQPLKYWPAFQQSHTFNSMSVFKNDNAIANQTTVNESDVKRNVEKINDIYECSNNTKSPCFPNSDSRIPLVNWKTSTNPTLQVRAYMLDLLLPFFTLDLLPFLNKVCECCNHMLLDNPKIKQDLPFAFCYLFSSYFSYKSSRQYTCSSEEISKVFRHLNRLGGSEYVLHLFAQIPKALCKELTDVRTLNHPLRSIFTFCFKNISNPPNLLKLLTKLYPRSDRANEVLYTQYLGFLTKRGDYQIAIYMFDEMYRTHHWSSFTACRLMIESLVRQNKFEEAISLYKKIIAKRPKIARDKKILNLLLYISTVSNRSPDAFKLALQSISNANQIPSFDVFSRLMSALVKYNMTEMILPLVKQYDHKFRNLYSPNIFLSIVQALVFCGDMVNIQRWYNMSRVNSELSRIKHLLNCFLNSSTVSLDVSMVLELLRDLKKKKIKVDERTLVICITIFSRRKDLFAMEKIHQYFSDQGIKTSNQAYAALLDAYIEAEDTEKIELYLGKIRRLGITEDVSINRMLMRLALDRLDWDLLEQCTKVAERKDPEGQDYLSTITMLYHVRQHELNLALRIFSGIQKPNVVHYSIAATVLGNLNQLDQLLLLEKRMESEGKAPTALSLVAFVSSYCKQGAEGLDEAKRYMSKNFQPDKRALLFNPRTANDMTYPPSLFSSLIKEYTSLGDIKEAKQVLSTYLEYFSKNITSKPDIPFAIASMRLYCSLHDTVLSRQFWDLILQVAQQNFITTDIAAVVDDKNIPSPSGVIPAYKSALNVAAETYFSFLASVNSFQELDQEWSRLEKLGFEYDDSLQNKRIIWLLYDDRLDAAIKRVYNIFLSSKRIEELIPDASSQNSIISFFLSPDSPLYFSTLKALRDKLDMAVEDDFVRISQGILVPTVKYLQTIRRDNEILFNLLAKV
Protein: 4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT) (P61922)
Organism: Mus musculus (Mouse)
Function: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Interaction partners:
- Succinate-semialdehyde dehydrogenase, mitochondrial
- Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
- Glutamate decarboxylase 1
- Glutamate decarboxylase 2
- Beta-ureidopropionase
- Aldehyde dehydrogenase X, mitochondrial
- Aldehyde dehydrogenase family 3 member A2
- Aldehyde dehydrogenase, mitochondrial
- Alpha-aminoadipic semialdehyde dehydrogenase
- 4-trimethylaminobutyraldehyde dehydrogenase
Sequence:
MAFLLITRRLACSSQKNLHLFIPGSRYISQAAAKVDIEFDYDGPLMKTEVPGPRSKELMKQLNTIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYNHPALAKLVQQPQNASTFINRPALGILPPENFVDKLQESLMSVAPRGMSQLITMACGSCSNENAFKTIFMWYRSKERGQRGFSKEELETCMVNQSPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFTTDNQQEEARCLEEVEDLIVKYRKKKRTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPSAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNVARVGKTLLTGLLDLQAQYPQFISRVRGRGTFCSFDTPDEAIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLSIFSGILADFK
Protein: Thyroid hormone receptor interactor 11 (Q3UFU7)
Organism: Mus musculus (Mouse)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLLEGTEDVPADFPNSGREENEATHSVLRSENERLKKLYTDLEEKHEASELQIKQQSSSYRSQLQQKEEEINHLKERQLALQDELLRLQSAAQSAHSGSGSAPAASASSSFSYGVSHRVSAFHEDDMDFGDVISSQQEINRLSNEVSRLESELGHWRHIAQTKVQGAQSSDQTEICKLQNIIKELKQNRSQDLDDHQHELSALQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVTVTDHSKVYEMQNTIQILQMEKVESTKQIEDLENKIKEIHKRLSSAEHDQEVWKKEQERLEVEKREMTEQCERLKLELSEAQQSALRQSDAAVEEETILPHSSSVAEVLRLQQALTDAENEIMRLRSLNQDISLAEDNQKLQMCVQTLEKEKSLLSQEKEELQVSLSKLSSEYEVIKSTASRDLDLFSQVHDLKHNLEAKEQELNQSIHENEILMAELEELDKQNQEATKHVILIKDQLSKQQSEGDSVIKKLKEELAGEKQRTHQLEDDKMNIIKELTVQKEKLTHSEQALSDLQLTKQKLEDKVEDLVDQLSKS
Protein: Transcription factor E2-alpha (Immunoglobulin-enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription regulator Pan) (P98180)
Organism: Mesocricetus auratus (Golden hamster)
Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P15806}.
Interaction partners:
- Catenin beta-1
- T-cell acute lymphocytic leukemia protein 1
- DNA-binding protein inhibitor ID-1 isoform X2
- Myogenic factor
- Rhombotin-2
- Myogenin
- LIM domain-binding protein 1 isoform X1
- Achaete-scute homolog 2
- LIM domain-binding protein 2 isoform X1
- Junction plakoglobin
Sequence:
MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKGRPASLAGTQFAGSGLEDRPSSGSWGNSDQNSSSFDPSRTYSEGAHFSESHNSLPSSTFLGPGLGGKSSERSAYATFGRDTSVSALTQAGFLPGELGLSSPGPLSPSGVKSGSQYYPSYPSNPRRRAADSGLDTQSKKVRKVPPGLPSSVYPSSSGDSYGRDAAAYPSAKTPGSAYPSPFYVADGSLHPSAELWSPPSQAGFGPMLGDGSSPLPLAPGSSSVGSGTFGGLQQQERMSYQLHGSEVNGTLPAVSSFSAAPGTYGGASGHTPPVSGADSLMGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPTYDGGLHGLSKMEDRLDEAIHVLRSHAVGTASDLHGLLPGHGALTTSFPGPVPLGGRHAGLVGGGHPEDGLTSGTSLLHTHASLPSQASSLPDLSQRPPDSYGGLGRAGAPAGASEIKREEKDDEESTSVADAEEDKKDLKAPRTRTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPPGHL
Protein: Olfactory receptor (Q7TRB9)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
MKIYRRMTHGNYSLVTEFILEGLTNRPELQMPLFFLFLGIYVVTIVANLGLITLISLNTHLHTPMYYFLFNLSFVDICYSSVFTPKMLINFVVEKNTISYTGCLTQLYFFCFFVITECYLLTAMAYDRYVAICKPLLYNVILSPRICAVFVFGAYVMGCWGSLAHTLCMARLTFCDANLVNHYLCDILPVLQLSCTSTYNNEVVVFVLVGMNIVVSTSTTFISYGFIIANILRISSTQGRAKAFNTCSSHIMTVSLFFGAAAFMYMQPSDVESMDKGKVASVFYTNVGPMLNPLIYSLRNKDVKVALKKTLKRKLFS
Protein: CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1) (Q9JLQ0)
Organism: Mus musculus (Mouse)
Function: Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Y5K6}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9Y5K6}. Cell junction {ECO:0000250|UniProtKB:Q9Y5K6}. Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles (By similarity). Located at podocyte slit diaphragm between podocyte foot processes (PubMed:10514378, PubMed:11733379). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase (By similarity). {ECO:0000250|UniProtKB:Q9Y5K6, ECO:0000269|PubMed:10514378, ECO:0000269|PubMed:11733379}.
Interaction partners:
- Nephrin
- Podocin
- Tight junction protein 1
- E3 ubiquitin-protein ligase CBL
- Synaptopodin
- Ras and Rab interactor 3
- Alpha-actinin-4
- Kin of IRRE-like protein 3
- Cadherin-3
- F-actin-uncapping protein LRRC16A
Sequence:
MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEPKDDNLPIKRERQGNVASLVQRISTYGLPAGGIQPHPQTKAIKKKTKKRQCKVLFDYSPQNEDELELIVGDVIDVIEEVEEGWWSGTLNNKLGLFPSNFVKELESTEDGETHNAQEESEVPLTGPTSPLPSPGNGSEPAPGSVAQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKTEKPLILQPLGSRTQNVEVTKPDVDGKIKAKEYCRTLFPYTGTNEDELTFREGEIIHLISKETGEAGWWKGELNGKEGVFPDNFAVQISELDKDFPKPKKPPPPAKGPAPKPDLSAAEKKAFPLKAEEKDEKSLLEQKPSKPAAPQVPPKKPTAPTKASNLLRSPGAVYPKRPEKPVPPPPPAAKINGEVSIISSKIDTEPVSKPKLDPEQLPVRPKSVDLDAFVARNSKETDDVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTQSPEKTLKLPKEDDSGNLKPLEFKKDASYSSKSSLSTPSSASKVNTAAFLTPLELKAKAEADDGKRNSVDELRAQIIELLCIVDALKKDHGKELEKLRKELEEEKAMRSNLEVEIAKLKKAVLLS
Protein: Ankyrin repeat protein (A8MS11)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAGREVKEYTNLSDPKDKKSGKGKIDDEDVTFQRMVAKMQEVAGERGGYLHGRGALDSDDLLYLKEQMEAEEDAERLLRRTEKRAFAAFKKAATQADSSPASIPLPLRVEPKPKSGIRQQDLLRKVVEVKPKRPKISTPSSPSLSPPVRSDRGPTEAKVHRDKQKEEAMPVLKKPGADRNDGKATESNGQGQNAPKGLLGLAYDSSDEED
Protein: Protein stum (Q9W2E1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for locomotion and mechanical sensing in proprioceptive neurons by transducing dendrite stretching into cellular responses. Required for transduction of mechanical stimuli in a specific subpopulation of proprioceptive neurons that sense joint angles. Probably does not constitute the mechanically activated channel and may rather serve as an accessory module required for the proper localization or function of the transduction channels.
Subcellular location: Cell projection, dendrite {ECO:0000269|PubMed:24626929}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Specifically localizes to the distal part of the sensory dendrite. Does not accumulate in any other part of the cell.
Interaction partners:
Sequence:
MQQTLSYSSSSPSPSPMPMPSASAAQTPPPNPNLTPNLNIRPSTNPIPRPRSTGGESAFQPAIIPVDYSYRTHTTRSILSAQSMAPSTFASNQSFVRQPSESDAQPYSSLFGDPVPPPLQPDDYFGTAAFETLRNGSVELPSSEEDALVAAMALNALIPAARERIFPSVPYSRTPRGSLLPYLQPPDIQILPNSSGGSSSEQLGSPNYRLLAPDDILNKPDVYDLENEVEEYTVVGQRMSFDDEEDEPTRTPSQAPAKLSVSSITTEDHRGLLSDSYSGRDWFRPAPQHFPEFTRIPRLRPSSKMIMSMKQDEGPLSPLATMIQDMNSSSSGGEERVAPNQSRPVSRDVVLSPKQYLEEQLGLERGSQRQSLEDYRMPPPPADPPPFRRTDLTEQDDSRSVEPEHSLKREMSPVIIRDSIPMGGDYRVEQPRPHKKTAFTILSTGQAASSAPRPPQQAPTRGRHASIQSTSTTTSSPAGRPQISPRRRSIFGSEPRLPELPSALGYTSHLVHQTTDDSPRPSVQFNMSGRHSRSKLAIPQKGILQQRDSLTSSIDTFTPRAQIRRGSIGRDPIRSLPYGQKIKSMETLPLINDQHRSSIPRLHYGSTMDLSRPEPAVFPPGALPRPLKPNLNPTRRQRGLLKIINKEESLTHNPPRSNWCSLDDLSRPSFDGTPNQARRRSSSTSPERRSSTQTVSDRRSSNLSSVTATTSDFSFRRPTLSTLPAAQTLSRMRRKSVQALSPNRIPNRIPSFGQRRQSIYQRDQEPKPLSRHGKIAKPSTLSPIIGTPNKDSSSAQSPNHRSSLMADAVDTPSEVSTRRDSVSRIPVRKSPDSRSSSPPKDFGIPASGRSSRASITRSPSRTMNAGSRSPSRSMHPSRTSSRESGRPGDSRSASRGPPSRPGSRLDQIGSRMDRPNSRLERSSSRAERSSSRADRPSSRFDVSNSRGNSRANSRLSINSSSLRSSSISPATMARNRSMRATTPSRRKSISLSPASAMMGRRKSISPDAVGQNRRVSSRGKPEPPEILSRRNSRSRIPTRSTKVASKSPPSSSKKRSKSPEKPKAMGSTPKSNKVGKGVTAKGSPKAKPKIAASAKPKTKTESLMKPPVKNANKTPVNGRPTTNAKKPASKAISTKDAKVEKGKETGKSVASKSNGKETESSVKSSKSQVTKTKPPGGTTSEAKKPATTKTHGITLEKGTNGTDPVGGIPPLAAQVGNAVLQAVEAVPAVTSEVTVPSTPGGKGAGGANMSKLVRMSSRMSLLSNKSTKVRSDSPQNRKVATVQEHATEKEETVGASSQPMSNDAAAILEKSQKTLENIQKTVTEATDEIHKTISENLTDLKSLENDLAADPSPTPSSGTTMARPGESASRTGTADGSIAPQSSGELPKSPFPPTQPIEASVSVLHPNESSAERIASVPEVECESSDLPTALDASESELVGNVMPTPESGADFKVDAKRRSPDGQGGSTAGSGGLAKSSSQEFLEDKDNVKKGGLCGCCSKLFMPCRRSRCSRCCRRRERNESAEDQPVLWSGNSSATTATNVQVIDETKPKRKKISDWLKSSCCRSCRKKPAIEEHEAHQEEVSKRTNQAANMSTGPRTRGKCGLCLSKVFCCRSVNRVDPTTGDETEMKQCCFCIPCRRGSRPNKKGSTVSWRDQDPELGIKPTESSVVEGASEAAMSAATDAGNDQVKEGCCKRFWLMLLCCRKRKRRESNARRQSIRAPPPSEDTRKKLHVDLVEYSSKMKGAIPVLPLYLAWFCAFCNVVFPGLGTLLSGLFCLCVGIPRFSQFDSARARIGSFIINIIVAVSQFFCVLFCFVGWGWSIWWGTIMLRCAKKLSKIKKVERLELEEEQRQAQLAEAGKNGVAEADKT
Protein: Ribonuclease MRP protein subunit POP4 (RNase MRP POP4) (RNA-processing protein POP4) (Q9ZW76)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Required for rRNA maturation, including 5.8S rRNA processing. Seems not involved in tRNA maturation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Ribonucleases P/MRP protein subunit POP1
- Uncharacterized protein At1g50910
- Protein GAMETOPHYTE DEFECTIVE 1
- Probable ribonuclease P/MRP protein subunit POP5
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein
- At4g22380
- At5g41270
- KRR1 family protein
- At4g01790
- Alba DNA/RNA-binding protein
Sequence:
MGTETVVHDQARWAMAAMERRLAVAKAQLLQQQQQKNEKDKKGTSDVDVSMKESHQADSLPTPSKTSIKKVDPKDDDSVAYTKLSHPVDENLLATNVKFSSAKGTIVDKVLHNLLRSGDSAQKYLQGTKSVKLDNYILLDNFVQSRSSASGSKKASQKDSKRSKSRMSMKRLKKSGALHIPKDLQKFDLFKPMHGMWESYMMKLIKVTGKIQLSLTLLSADLHGAFMFVAECKIASFTGVQGIMVRETSETFGIITRDDKFRVVPKKLSVFIIQLDCWKITLHGDKFISRDNIVQR
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (CI-B15) (NADH-ubiquinone oxidoreductase B15 subunit) (Q9CQC7)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O95168}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 beta subcomplex subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
Sequence:
MSGSKYKPAPLATLPSTLDPAEYDVSPETRRAQVERLSIRARLKREYLLQYNDPKRVSHIEDPALIRWTYARSANIYPNFRPTPKNSLLGAVAGFGPLIFWYYVFKTDRDRKERLIQEGKLDRKFNISY
Protein: Proteinaceous RNase P 3 (EC 3.1.26.5) (F4JKB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA).
Subcellular location: Nucleus {ECO:0000269|PubMed:20473316}.
Interaction partners:
- Protein GAMETOPHYTE DEFECTIVE 1
- Proteinaceous RNase P 1, chloroplastic/mitochondrial
- Ribonucleases P/MRP protein subunit POP1
- Proteinaceous RNase P 2
- Probable ribonuclease P/MRP protein subunit POP5
- Uncharacterized mitochondrial protein AtMg01280
- Pentatricopeptide repeat-containing protein At3g06430, chloroplastic
- Pentatricopeptide repeat-containing protein At5g04810, chloroplastic
- Pentatricopeptide repeat-containing protein At1g10270
- Small ribosomal subunit protein mL104
Sequence:
MKLKKPSLPSSLLCAVPPCLSQIRLLIPRRVRVSSSTFANAKLVTLRNHTVNLHIYYCSMAGTDNRRSRHDDESPKNPNKKKKGNRNPEKSLLINLHSCSKRKDLSAALALYDAAITSSDIRLNQQHFQSLLYLCSAFISDPSLQTVAIDRGFQIFDRMVSSGISPNESSVTAVARLAAAKGDGDYAFKLVKDLVAVGGVSVPRLRTYAPALLCFCDTLEAEKGYEVEDHMDASGIVLEEAEISALLKVSAATGRENKVYRYLQKLRECVGCVSEETSKAIEEWFYGVKASEVSDNGIGSDIELLRAAVLKNGGGWHGLGWVGEGKWIVKKGNVSSAGKCLSCDEHLACVDTNEVETEDFVNSLVTLAMERKAKMNSCEPMADFSEFQEWLEKHGDYEAILDGANIGLYQQNFADGGFSLPQLEAVVKELYNKSGSKKQPLILLHKKRVNALLENPNHRNLVEEWINNNVLYATPPGSNDDWYWLYAAAKLKCLLVTNDEMRDHIFELLSNSFFQKWKERHQVRFTFVKGCLKLEMPPPFSVVIQESEKGSWHVPITSQDKEESLRSWMCITRQSS
Protein: mRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) (VTF large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme D1 subunit) (mRNA-capping enzyme large subunit) [Includes: Polynucleotide 5'-triphosphatase (EC 3.6.1.74) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase); mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) (mRNA cap methyltransferase)] (P04298)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Catalytic subunit of the mRNA capping enzyme which catalyzes three enzymatic reactions: the 5' triphosphate end of the pre-mRNA is hydrolyzed to a diphosphate by RNA 5' triphosphatase; the diphosphate RNA end is capped with GMP by RNA guanylyltransferase and the GpppN cap is methylated by RNA (guanine-N7) methyltransferase. Heterodimeric mRNA capping enzyme catalyzes the linkage of a N7-methyl-guanosine moiety to the first transcribed nucleotide (cap 0 structure), whereas the methyltransferase OPG102 is responsible for a second methylation at the 2'-O position of the ribose (cap 1 structure). Also involved in early viral gene transcription termination and intermediate viral gene transcription initiation. Early gene transcription termination requires the termination factor VTF, the DNA-dependent ATPase NPH-I/OPG123 and the RAP94/OPG109 subunit of the viral RNA polymerase, as well as the presence of a specific termination motif. Binds, together with RAP94/OPG109, to the termination motif 5'-UUUUUNU-3' in the nascent early mRNA.
Subcellular location: Virion {ECO:0000305}. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome.
Interaction partners:
Sequence:
MDANVVSSSTIATYIDALAKNASELEQRSTAYEINNELELVFIKPPLITLTNVVNISTIQESFIRFTVTNKEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIVWEKKSLVTENRLHKECLLRLSTEERHIFLDYKKYGSSIRLELVNLIQAKTKNFTIDFKLKYFLGSGAQSKSSLLHAINHPKSRPNTSLEIEFTPRDNETVPYDELIKELTTLSRHIFMASPENVILSPPINAPIKTFMLPKQDIVGLDLENLYAVTKTDGIPITIRVTSNGLYCYFTHLGYIIRYPVKRIIDSEVVVFGEAVKDKNWTVYLIKLIEPVNAINDRLEESKYVESKLVDICDRIVFKSKKYEGPFTTTSEVVDMLSTYLPKQPEGVILFYSKGPKSNIDFKIKKENTIDQTANVVFRYMSSEPIIFGESSIFVEYKKFSNDKGFPKEYGSGKIVLYNGVNYLNNIYCLEYINTHNEVGIKSVVVPIKFIAEFLVNGEILKPRIDKTMKYINSEDYYGNQHNIIVEHLRDQSIKIGDIFNEDKLSDVGHQYANNDKFRLNPEVSYFTNKRTRGPLGILSNYVKTLLISMYCSKTFLDDSNKRKVLAIDFGNGADLEKYFYGEIALLVATDPDADAIARGNERYNKLNSGIKTKYYKFDYIQETIRSDTFVSSVREVFYFGKFNIIDWQFAIHYSFHPRHYATVMNNLSELTASGGKVLITTMDGDKLSKLTDKKTFIIHKNLPSSENYMSVEKIADDRIVVYNPSTMSTPMTEYIIKKNDIVRVFNEYGFVLVDNVDFATIIERSKKFINGASTMEDRPSTRNFFELNRGAIKCEGLDVEDLLSYYVVYVFSKR