wanglab/gogpt-training-data huggingface dataset:
Protein: Probable conserved transmembrane protein (O33206)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Probable multifunctional mycocerosic acid synthase membrane-associated Mas
- Phthioceranic/hydroxyphthioceranic acid synthase
- Mycoketide-CoA synthase
- Mycocerosic acid synthase-like polyketide synthase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Cytochrome bc1 complex cytochrome b subunit
- Probable polyketide synthase Pks17
- Uncharacterized protein Rv1708
- Possible segregation and condensation protein ScpB
- Triple specificity protein phosphatase PtpB
Sequence:
MLQRIARELLSGVAVAIVALPLAIAFGITATGTSQGALIGLYGAIFAGFFAAVFGGTPGQVTGPTGPITVVATATIAEHGLEGAFFAFILAGVFQILFGACRLGSLIRYVPHPVISGFMGGIAILIIMTQLDQVRSSSLLVLVTVVLLLASGRFIKAIPPSLLVLVLVSSVLPLAAPWLRDLRAGPVSINRTVDYIGEIPQAMPSFDFPQVANSTMLQVLLSAVAIALLGSLDSLLTSLVMDNIRGTRHRSNKELIGQGIGNIAAGLFGGLSGAGATVRSVVNVRNGGQTALSAATHSVVLFVFVAGLGAVVQYIPLAVLSGILILVAVGMFDWHAMRKAHVSPRGDVIVMFTTMIITVVVDLTIAVMVGIALSLLVHRLRSRQRKAKVTQDDTGTYRIDGPLSFLSVDGVFGSLRDGREDVSLDLQHVTYLDTSGARALLYFIDHSEKDGVAVSIKRIPPRLESQLTALADNEQRDKLRTVLESA
Protein: AP complex subunit sigma (A0A0B4KHB7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MMLFMLLFSRQGKLRLQKWYMAYPDKVKKKITRELVTTILARKPKMCSFLEWKDCKIVYKRYASLYFCCAIEQNDNELLTLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDELLIGGEIQETSKKNVLKAIASQDLLQEQEEFFYSLQ
Protein: Transportin-2 (Karyopherin beta-2b) (O14787)
Organism: Homo sapiens (Human)
Function: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Nuclear RNA export factor 1
- Importin-9
- Nuclear pore complex protein Nup153
- Importin-7
- Nuclear pore complex protein Nup98-Nup96
- Nuclear pore glycoprotein p62
- GTP-binding nuclear protein Ran
- Zinc finger CCCH domain-containing protein 14
- Nuclear transport factor 2
- Heterogeneous nuclear ribonucleoprotein A1
Sequence:
MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTGRLTSPSAIPAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV
Protein: DNA repair protein crb2 (Checkpoint mediator protein crb2) (Cut5-repeat binding protein 2) (RAD9 protein homolog) (P87074)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase. Plays a role in the response to DNA damage. Interaction with rad4 via its phosphorylation sites in the N-terminus couples the DNA checkpoint apparatus to chromatin via interaction of its C-terminal BRCT domains with epigenetic modifications on histones H4 and H2A, respectively, in the G1/S phase of the cell cycle, and facilitates recruitment of the checkpoint kinase chk1.
Subcellular location: Nucleus {ECO:0000269|PubMed:14655046, ECO:0000269|PubMed:15550243, ECO:0000269|PubMed:9407031}. Note=Recruited to sites of DNA damage, such as double stand breaks. {ECO:0000269|PubMed:18826944, ECO:0000269|PubMed:20679485, ECO:0000269|PubMed:24074952}.
Interaction partners:
- S-M checkpoint control protein rad4
- Serine/threonine-protein kinase chk1
- Serine/threonine-protein kinase cds1
- Protein kinase rad3
- BRCT-containing protein 1
- DNA repair protein rad9
- DNA damage checkpoint control protein rad1
- Mediator of replication checkpoint protein 1
- Checkpoint protein rad17
- Checkpoint protein hus1
Sequence:
MEVNDTSLHKGFGLDINSQRVFGAQAAISRNNYSKVNASINPSPPRSNDNSNKEFSYSKDVNNNGAVEELSLTQLFEVPSQAAFAKQSSQDISDDELIQHDSRKVISSPYSPKQTHTVLKRLYDRQSVISDHEKLLTPQNVSNSSQILSPFTSLLPSTLSTLKDTPLSVSQNEKNLETVGEVLVPETVAQHRTKFYDYTLDEMENETESGQVETTPTRLATSLGSPVLYGRVESTPPAFLPETSEKQYKRKFSFTEPSSEKVDNTETKFSKKTKNINDENFPNPFNVISSYETSASPSTVIDQSSQVSSIFVNKRLRKSVNNQAISRSDSLSLDTPKIDSLFTRASIKPLKPSQSPNSRRSFKNRVLAFFKGYPSFYYPATLVAPVHSAVTSSIMYKVQFDDATMSTVNSNQIKRFFLKKGDVVQSTRLGKIKHTVVKTFRSTNEQLSLIAVDALNNDMVILAHGEIEVTVPISTIYVAPVNIRRFQGRDLSFSTLKDMKFEETSFLPSHDSQRNRSSLKERDSSFVKKNLDSESNQLIFDDCVFAFSGPVHEDAYDRSALETVVQDHGGLVLDTGLRPLFNDPFKSKQKKLRHLKPQKRSKSWNQAFVVSDTFSRKVKYLEALAFNIPCVHPQFIKQCLKMNRVVDFSPYLLASGYSHRLDCTLSQRIEPFDTTDSLYDRLLARKGPLFGKKILFIIPEAKSWQKKIENTEQGQKALAHVYHALALGADVEIRPNVAHLECDLILTMDGNIVDETNCPVVDPEWIVECLISQSDIST
Protein: Uncharacterized Nudix hydrolase P35G2.12 (EC 3.6.-.-) (Q9P791)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Phosphoglucomutase
- Ribose-phosphate pyrophosphokinase 1
- Ribose-phosphate pyrophosphokinase 2
- Ribose-phosphate pyrophosphokinase 5
- Probable phosphoribomutase
- SAGA complex subunit Sgf73
- SAGA complex subunit Sus1
Sequence:
MSQDQKPKVLEVSNLENQDAKWTSLKKIRWQDEKGKIRFWEMAERTTRSEANVDAVAILAIVPIDGSPHVLCQKQFRPPIGKFCIEIPAGLVDSKESCEDAAIRELREETGYVGTVMDSTTVMYNDPGLTNANLKIILADIDMSKPENQNPQQQLDDGEYIENFPIKLSSLQEELFSLEKKGFAIDVRLSTFALGLHAGLKYLSS
Protein: Mannosyltransferase (EC 2.4.1.-) (Q585D3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363075}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363075}.
Interaction partners:
- Mannosyltransferase
- Alpha-1,3-mannosyltransferase, putative
- Dolichol-phosphate mannosyltransferase subunit 1
- 1-phosphatidylinositol 4-kinase
Sequence:
MWLFLGAVLLVLSHCFASYILPIADCDETFNFLEPMHFLMYGSGLQTWENCPRFALRSWFFSWLYVGPITIISKAVSIYNPSGLRNIDVYFLLRAFSGVVTALSEIFFVGGVRKVFGKRVAAAALTLLLFNYPITHAAVSILPTSYAMINYFVAVGCWLRTDGSLVKCITRVEGKVPSRMKRSVMGGSQFQAINFAIFGTVFSVVSSTVIGWPFAALLAVPMALDMLVRFPLASTVSLLLSLAVVVPLSVYFDTLYYNGCHGGNGKITWSALNLVRYNMFMGGEGRGPELYGVEPWYFFFKNLLLNAHLMFVACLLSPFVVLLKPSTTSWVSNATTNSDEIDAGETTGEKGRKTQKSPTTKPDTRPVEPTVSRGRGLLYISPFFLWFAFWLKVSHKEERFMSPAFPFLALAAALSFTHLTFAGTARSVNSENGAVLHSASTRAEPSGRRKQLPGCWLQRMRHTFFLTTGCIVLSFIVTVSLSRTAAIHKFYVGPQQKLYDNYATVRELARRKASDAPQKGEKTLYTLCVGREWYRFPSSFFLDPLHARIAFIRSLGVDCAMPLPFASGDGNATCQCGAEGVNDLNKAIPEQFVQDVAKDCDAVFDTVSPNEDDQESADFPRDVFKYEIGEGQTHWLLDAERTPMWCRVLYYPLGVSERCVSRRRVVLLSKQNPK
Protein: Male-specific transcript 36Fa (Q8INX4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPHKKTKHLKAVVPGMVSLEGEQFDSWEIPFPLPEQEDPSMCRDEFLKDLIREHESRVASLVVRSTVRDVSIVKRPVELQDTDVKEAEAMVVLQMAQKRQRTSVRRTMEEVIASIRLRSTIIADLIRQVQKAAIEFLSVRLLRQLRLFSMPWPGDLEETPNNLFSWSLDDFLLRLDVKQIYLDVLNRERSVKDLDCVKFCKDLSEIEHLIHEIRRDFRDDVDLCENSLHLLKNAQYHMNAPWVKSLNDNIENLASSASVALLNEQSGSLTSLRRNSSAMIVFERKSALNPIETRYQINWFKSCTDQRLTRMNERNVEIKRELQDLEVQAVQDEKVQYSSGLMYELEVGKLRESIRNWQDRLDTDLEHADVMCTVSRLALQKLKDDLKFYMEQKDMYLQRIKEVQALIDQERMIREERELAALKRMSRGSLRKSVPKSTKNFQKKSKGKSEKKSELKSEIKSDTKPEMKTERKSDMKAERKSKTMAEKSQRKSTNSKME
Protein: 6-phosphofructo-2-kinase domain-containing protein (Q9N590)
Organism: Caenorhabditis elegans
Interaction partners:
- ATP-dependent 6-phosphofructokinase 2
- ATP-dependent 6-phosphofructokinase 1
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
- Probable phosphoglycerate kinase
- Fructose-bisphosphate aldolase 1
Sequence:
MPGPAGVPQRKMTYFVPKSDNSNEQVRVPNVIALVGLPARGKTYISHKLCRYLNWIGIKTKAFNVGEYRRRACNLEEEGENEFFSPNNARGQKIRDECAKLAIEDMGRYLDNKEGEVAILDATNTTRDRRKLLMEFCRNMMHEPPFRVFFVESVCDDPDIINSNITEVKINSPDYKGIMSQEEAKEDFLKRIENYRMQYEPLDEDHDEELSYIKVINAGKSFYVHNVNGHVQSRVVYFLMNIHLLPRSIYLSRHGESEYNRIGRLGGDSPLSENGLNYAGKLREYFEKEDLDDFRVWSSQKIRAAQTASHLKDLAGHTEFWKCLDEIDAGICEGLTYEDFEARYPKQFAERDKDKYHYRYPSGESYEDLVARLEPVIMELERQSNVLVISHQAVLRCILAYFTNKNRDDLPYLKVPLHTVIKLTPKAYSCEIELFKFDIEAVNTYREKPQ
Protein: Transmembrane BAX inhibitor motif containing 4 (G3XAA5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MADPDPRYPRSSIEDDFNYGSSVASATVHIRMVLQRDCTFSKQYMRIPSAPSATLNIIRFFHLRQSGRSGMVNIFYKGPTFLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMHKLSPEEYVLAAISLYLDIINLFLHLLRFLEAVNKK
Protein: Tumor necrosis factor (TNF-alpha) (Q9DEP9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- TNFR-Cys domain-containing protein
- TNFR-Cys domain-containing protein
- TNFR-Cys domain-containing protein
- TNFR-Cys domain-containing protein
- TNFR-Cys domain-containing protein
- TNFR-Cys domain-containing protein
- TNFR-Cys domain-containing protein
- TNFR-Cys domain-containing protein
- TNFR-Cys domain-containing protein
- TNFR-Cys domain-containing protein
Sequence:
MEGYAMTPEDMERGLENSLVDSGPVYKTTVTAVAERKASRGWLWRLCGVLLIAALCAAAALLFAWCQHGRLATMQDGMEPQLEIFIGAKDTHNTLKQIAGNAKAAIHLEGEYNPNLTADTVQWRKDDGQAFSQGGFKLQGNQILIPHTGLFFVYSQASFRVKCNGPGERTTPLSHVIWRYSDSIGDKGNLLSGVRSVCQQNYGNDESNIGEGWYNAVYLSAVFQLNEGDKLWTETNRLTDVEPEQGKNFFGVFAL
Protein: Protein PAF1 homolog (Protein EARLY FLOWERING 7) (Protein VERNALIZATION INDEPENDENCE 2) (F4HQA1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3). Involved in regulation of flowering time. Required for the expression of the flowering repressors and MAD-box genes FLC, AGL27/FLM and AGL31/MAF2. Required for histone H3 trimethylation on 'Lys-4' H3K4me3 at the FLC and AGL27/FLM loci. Involved in the control of seed dormancy and germination.
Subcellular location: Nucleus {ECO:0000269|PubMed:20363855}.
Interaction partners:
- Protein CTR9 homolog
- Protein CDC73 homolog
- Protein LEO1 homolog
- Protein RTF1 homolog
- FACT complex subunit SSRP1
- FACT complex subunit SPT16
- WD repeat-containing protein VIP3
- FACT complex subunit
- Transcription elongation factor SPT4 homolog 1
- Transcription elongation factor SPT4 homolog 2
Sequence:
MASYRPPYPPLPQPPSQNSLAPPPPPPSLPPPVPPPPPSHQPYSYPPPPPPPPHAYYQQGPHYPQFNQLQAPPPPPPPSAPPPLVPDPPRHQGPNDHEKGASKQVGRRERAKPDPSKHHHRSHLPHSKKIETEEERRLRKKRELEKQRQDEKHRQQMKNSHKSQMPKGHTEEKKPTPLLTTDRVENRLKKPTTFICKLKFRNELPDPSAQLKLMTIKRDKDQFTKYTITSLEKLWKPKIFVEPDLGIPLDLLDLSVYNPPKVKAPLAPEDEELLRDDDAVTPIKKDGIRRKERPTDKGMSWLVKTQYISSINNESARQSLTEKQAKELREMKGGINILHNLNNRERQIKDIEASFEACKSRPVHATNKNLQPVEVLPLLPYFDRYDEQFVVANFDGAPIADSEFFGKLDPSIRDAHESRAILKSYVVAGSDTANPEKFLAYMVPSLDELSKDIHDENEEISYTWVREYLWDVQPNANDPGTYLVSFDNGTASYLPLPMRLNLRKKRAREGRSSDEIEHFPVPSRVTVRRRSTVSVIEHKDSGVYSSRVGASSSKMRRLEDEGGLGRSWKHEPEQDANQYSDGNEDDYSE
Protein: cDNA FLJ31867 fis, clone NT2RP7001856, highly similar to Polyhomeotic-like protein 2 (B3KPJ4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPLGPVTPALPLQCPTANLHKPGGSQQCHPPTPDTGPQNGHPEGVPHTPQRRFQHTSAVILQLQPASPVPQQCVPDDWKEVAPGEKSVPETRSGPSPHQQAIVTAMPGGLPVPTSPNIQPSPAHETGQGIVHALTDLSSPGMTSGNGNSASSIAGTAPQNGENKPPQAIVKPQILTHVIEGFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKLPQQDHTTTTDSEMEEPYLQESKEEGAPLKLKCELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFHSDRSKLQKAGAATHNRRRASKASLPPLTKDTKKQPTGTVPLSVTAALQLTHSQEDSSRCSDNSSYEEPLSPISASSSTSRRRQGQRDLELPDMHMRDLVGMGHHFLPSEPTKWNVEDVYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISMLKDS
Protein: Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) (P15261)
Organism: Mus musculus (Mouse)
Function: Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:2137461, ECO:0000269|PubMed:2530216, ECO:0000269|PubMed:2530582, ECO:0000269|PubMed:2531896, ECO:0000269|PubMed:2532365}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Interferon gamma
- Tyrosine-protein kinase JAK2
- Ifngr2 protein
- Tyrosine-protein kinase JAK1
- Signal transducer and activator of transcription 1
- Interferon alpha/beta receptor 1
- Suppressor of cytokine signaling 1
- Non-receptor tyrosine-protein kinase TYK2
- Interferon alpha/beta receptor 2
- Interferon beta
Sequence:
MGPQAAAGRMILLVVLMLSAKVGSGALTSTEDPEPPSVPVPTNVLIKSYNLNPVVCWEYQNMSQTPIFTVQVKVYSGSWTDSCTNISDHCCNIYEQIMYPDVSAWARVKAKVGQKESDYARSKEFLMCLKGKVGPPGLEIRRKKEEQLSVLVFHPEVVVNGESQGTMFGDGSTCYTFDYTVYVEHNRSGEILHTKHTVEKEECNETLCELNISVSTLDSRYCISVDGISSFWQVRTEKSKDVCIPPFHDDRKDSIWILVVAPLTVFTVVILVFAYWYTKKNSFKRKSIMLPKSLLSVVKSATLETKPESKYSLVTPHQPAVLESETVICEEPLSTVTAPDSPEAAEQEELSKETKALEAGGSTSAMTPDSPPTPTQRRSFSLLSSNQSGPCSLTAYHSRNGSDSGLVGSGSSISDLESLPNNNSETKMAEHDPPPVRKAPMASGYDKPHMLVDVLVDVGGKESLMGYRLTGEAQELS
Protein: T-box transcription factor mls-1 (Mesodermal lineage specification protein 1) (O17212)
Organism: Caenorhabditis elegans
Function: Probable transcription factor required for the cell fate specification of non-striated uterine muscle precursor cells. Furthermore, may function with the transcriptional corepressor unc-37.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Interaction partners:
- Homeobox protein mls-2
- Transcription factor unc-37
Sequence:
MNRNFSIDAILARKPVEKRKQIITKDNCKFIRVFLQSSNLWRRFHNLGTEMIVTKSGRRMFPTLSVIIAGLDPVKSYVVMVDLECIEMKRFRYSFHQSKWISTGPGESELPSRMFVHTDSPARGAHWMRAPVSFDKMKLTNNQLDNNGHIIVNSMHKYRPRVHIIEQDDSQKRHTFSFEETEFIAVTAYQNHRITSLKIESNPFAKGFRECEVQGIEMNSVGGMTGGPAFQSVFPLIFPYFANLASNMNVNK
Protein: FLYWCH transcription factor 3 (Q9XWQ6)
Organism: Caenorhabditis elegans
Function: Probable transcription factor. May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-2.
Interaction partners:
- Alpha-soluble NSF attachment protein
- Putative T-box protein 36
- C2H2-type domain-containing protein
- One cut domain family member
- Zinc finger protein lsy-27
- Zinc metalloproteinase nas-17
- FLYWCH-type domain-containing protein.
- Homeodomain-only protein
- Nuclear Hormone Receptor family
- FLYWCH transcription factor 1
Sequence:
MNLASQISQAKTGNATMEWAKNYVSKLNDGQLALLQKMYADHQAKLKASEDEKKKKEMEELKMKAQQQAILDSLTQQIPIMVDVLRSSTSPDSQPSSSSSVMSSTDEDQITVKDVLIGKINKAQRQSSPNSSKPYTPRGIRERVLFDEHLYVFDKCSYDSKKRFFRCERKNTCPARIHTPFDAERVIHKVQVHNHPPPTTFDLAHYNIDYGKVKSGHILSLNGPQQTKNLLPPSLLTPKSDLEDETLSTKTEQKNASTMNILLSMTNNCDGRKPITLRLPDLFNKISEMEIHDMEMTLTKFLLENRELRTDLISRNGDLPVFFPNAHNDELVLFVADQHENDSVFQMIRVSERNEKSIRQAIQEHLQKVSNRSLMMNISSKINVPLSQQMIDQWRTEEFIRLDSSKPNFWKIHHVSKLQD
Protein: Syndecan-1 (SYND1) (CD antigen CD138) (P26260)
Organism: Rattus norvegicus (Rat)
Function: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:P18827}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P18827}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000250|UniProtKB:P18827}.
Interaction partners:
- Fibroblast growth factor 2
- Glypican-1
- Syndecan-4
- Syndecan-2
- Matrix metalloproteinase-9
- Heparanase
- Uncharacterized protein.
- Fibronectin
- Thrombospondin-2
- Thrombospondin-4
Sequence:
MRRAALWLWLCALALRLQPALPQIVTANVPPEDQDGSGDDSDNFSGSGTGALPDMTLSRQTPSTWKDVWLLTATPTAPEPTSRDTEATLTSILPAGEKPEEGEPVAHVEAEPDFTARDKEKEATTRPRETTQLPVTQQASTAARATTAQASVTSHPHGDVQPGLHETLAPTAPGQPDHQPPSVEDGGTSVIKEVVEDETTNQLPAGEGSGEQDFTFETSGENTAVAGVEPDLRNQSPVDEGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVAFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
Protein: Claudin domain-containing protein 2 (Q8NHS1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGVKRSLQSGGILLSLVANVLMVLSTATNYWTRQQEGHSGLWQECNHGICSSIPCQTTLAVTVACMVLAVGVGVVGMVMGLRIRCDEGESLRGQTTSAFLFLGGLLLLTALIGYTVKNAWKNNVFFSWSYFSGWLALPFSILAGFCFLLADMIMQSTDAISGFPVCL
Protein: LARP4 protein (Q6P4E2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTDGMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFIPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKGLFKSENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSIYSHPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPTPYFETPLAPFPNGSFVNGFNSPGSYKTNAAAMNMGRPFQKIV
Protein: Interleukin-22 (Q198B4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSFSLMGTLAASCLLLVALWAQKADALPINSQCKLEAANFQQPYIVNRTFMLAKEASLADNNTDVRLIGEELFRGVKAKDQCYLMKQVLNFTLEDVLLPQSDRFQPYMQEVVPFLTKLSIHLSPCHISGDDQNIQKNVRQLKETVQKLGESGEIKAIGELDLLFMSLRNACV
Protein: Multidrug efflux pump accessory protein AcrZ (AcrAB-TolC multidrug efflux pump accessory protein AcrZ) (Acridine resistance protein Z) (P0AAW9)
Organism: Escherichia coli (strain K12)
Function: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01484, ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01484, ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}. Note=In sucrose cushions fractionates with both the inner and outer membranes.
Interaction partners:
- Multidrug efflux pump subunit AcrB
- Multidrug efflux pump subunit AcrA
- Outer membrane protein TolC
- Cytochrome bd-I ubiquinol oxidase subunit X
- Putative inhibitor of glucose uptake transporter SgrT
- Small protein MgtS
- Small protein MntS
Sequence:
MLELLKSLVFAVIMVPVVMAIILGLIYGLGEVFNIFSGVGKKDQPGQNH
Protein: Hypocretin neuropeptide precursor (Hypocretin) (Hcrt) (Orexin precursor) (Prepro-orexin) (Preprohypocretin) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)] (O55232)
Organism: Rattus norvegicus (Rat)
Function: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function.
Subcellular location: Rough endoplasmic reticulum {ECO:0000269|PubMed:9419374}. Cytoplasmic vesicle {ECO:0000269|PubMed:9419374}. Synapse {ECO:0000269|PubMed:9419374}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000269|PubMed:9419374}.
Interaction partners:
- Pro-MCH
- Orexin/Hypocretin receptor type 1
- Orexin receptor type 2
- Pro-neuropeptide Y
- Leptin
- Pro-opiomelanocortin
- Oxidation resistance protein 1
- Appetite-regulating hormone
- Agouti-related protein
- Protein c-Fos
Sequence:
MNLPSTKVPWAAVTLLLLLLLPPALLSLGVDAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRPGPPGLQGRLQRLLQANGNHAAGILTMGRRAGAELEPYPCPGRRCPTATATALAPRGGSRV
Protein: C2H2-type domain-containing protein (Q8BLA2)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVTHDTMSVFCPGTRLPQHPRGYSTEKPYKCEECGKAFRRASHLSQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYTCKECGKAFTQSSQLILHHRIHTGEKPYKCEACGKAFIRSSQLSRHQKVHTGEEPFECKECGKAFTQNSQLTLHQRLHTGEKLYDCKECRKVFTQLSQLILHRRIHTGEKPYECNECGKAFICGSQLSQHRKIHNGEKPYECKECGKAFIRGSLLMQHQRIHTGEKPYKCDECGKAFIRGSQLTQHQRVHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYKCKECGKNFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCSECGKAFARGLLLIQHQRIHTGEKPYQCRECGKAFIRSSQLTQHQRTHTGEKPYECRECGKAFGHGSQLTLHQRVHTGEKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCKECEKAFTRESQLMRHQRIHIRGKSLDCKECRIDFNHHSQIFI
Protein: Protein B-Myc (Q6P8Z1)
Organism: Mus musculus (Mouse)
Function: Seems to act as an inhibitor of cellular proliferation.
Subcellular location: Nucleus {ECO:0000269|PubMed:11039906}.
Interaction partners:
- Protein max
- F-box/WD repeat-containing protein 7
- Myc box-dependent-interacting protein 1
- S-phase kinase-associated protein 1
- Transformation/transcription domain-associated protein
Sequence:
MPLHVSLANGNRDLDYDSVQPYFMCDDEEEDVHHQQPPQPPAPSEDIWKKFELLPTPRPSPGHAGLYSPPCEAVAVSFAPRDHDGDSFSIADLPELPGGDAVKQSFVCDPDDETFVKNIILQDCMWNGFSASAKLVSKLDPYQAVRKEGTGVSLAADVEPATPPDCTCNT