wanglab/gogpt-training-data huggingface dataset:
Protein: BPI fold-containing family B member 4 (Ligand-binding protein RY2G5) (Long palate, lung and nasal epithelium carcinoma-associated protein 4) (P59827)
Organism: Homo sapiens (Human)
Function: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).
Subcellular location: Secreted {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12837268}.
Interaction partners:
- BPI fold-containing family A member 2
- BPI fold-containing family A member 1
- BPI fold-containing family A member 3
Sequence:
MWMAWCVAALSVVAVCGTSHETNTVLRVTKDVLSNAISGMLQQSDALHSALREVPLGVGDIPYNDFHVRGPPPVYTNGKKLDGIYQYGHIETNDNTAQLGGKYRYGEILESEGSIRDLRNSGYRSAENAYGGHRGLGRYRAAPVGRLHRRELQPGEIPPGVATGAVGPGGLLGTGGMLAADGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGKSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLADVLPDLLCPIVDVVLGLVNDQLGLVDSLIPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGGLIDYPLGWPAVSPKPMPELPPMGDNTKSQLAMSANFLGSVLTLLQKQHALDLDITNGMFEELPPLTTATLGALIPKVFQQYPESCPLIIRIQVLNPPSVMLQKDKALVKVLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEVLVEKIFDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA
Protein: Aprataxin-like protein (EC 3.6.1.71) (EC 3.6.1.72) (Hit family protein 3) (O74859)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable tyrosyl-DNA phosphodiesterase
- ATP-dependent DNA helicase II subunit 1
- DNA ligase 3
- Bifunctional polynucleotide phosphatase/kinase
- ATP-dependent DNA helicase II subunit 2
- DNA ligase 4
- DNA topoisomerase 1
- DNA ligase 1
- DNA-
- Flap endonuclease 1
Sequence:
MSVHKTNDAFKVLMNSAKEPIVEDIPKKYRKQSFRDNLKVYIESPESYKNVIYYDDDVVLVRDMFPKSKMHLLLMTRDPHLTHVHPLEIMMKHRSLVEKLVSYVQGDLSGLIFDEARNCLSQQLTNEALCNYIKVGFHAGPSMNNLHLHIMTLDHVSPSLKNSAHYISFTSPFFVKIDTPTSNLPTRGTLTSLFQEDLKCWRCGETFGRHFTKLKAHLQEEYDDWLDKSVSM
Protein: Chloroplast geranylgeranyl diphosphate synthase (EC 2.5.1.29) (F8UR58)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Interaction partners:
Sequence:
MSFVNSITTWVPAQSIYCLENGRSSSMRSNLCHPLKNQLPISFFLSGTIRKPIFSCSRLSISAIITKEQTQEESESKSKKEVAFSSSSSFDFKAYMIGKANSVNKALEDAVLVREPLKIHESMRYSLLAGGKRVRPMLCIAACELFGGTESVAMPSACAVEMIHTMSLMHDDLPCMDNDDLRRGKPTNHKVFGEDVAVLAGDALLAFAFEHIATATKGVSSERIVRVVGELAKCIGSEGLVAGQVVDVCSEGIADVGLEHLEFIHIHKTAALLEGSVVLGAIVGGANDEQISKLRKFARCIGLLFQVVDDILDVTKSSQELGKTAGKDLVADKVTYPKLLGIDKSREFAEKLNREAQEQLAEFDPEKAAPLIALANYIAYRDN
Protein: Chromatin assembly factor 1 subunit FSM (CAF-1 subunit FSM) (CAF-1 p150 homolog) (Protein FASCIATA 1 homolog) (Protein FLATTENED SHOOT MERISTEM) (B2ZX90)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Component of the chromatin assembly factor complex (CAF-1) involved in chromatin assembly following DNA replication and DNA repair. Required for several aspects of development, including apical meristem maintenance by regulating the durations of the S- and G2-phases of the cell cycle through its chromatin assembly activity.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Chromatin assembly factor 1 subunit FAS2 homolog
- DNA polymerase alpha catalytic subunit
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM5
- Os05g0553800 protein
- Os01g0685200 protein
- Proliferating cell nuclear antigen
- DNA replication licensing factor MCM3
- Os05g0173700 protein
- DNA replication licensing factor MCM2
Sequence:
MEGGKLLGVAHPEPANNIDADLRYDLGQSRMQVDGPVVLNRSAELEPSDSMAIDDVPVEASSQPAPAKQSPALMDTIVEVQKQLKRKRASSGPALAAADKDALVAGCCQELEGLLEYYREVSGHRMQFEVGNLSTNAAIGCLLEESSLGLSKLVDEIYEKLKGMEGVSATSVRSSVLLIGQRMMYGQSSPDADVLEDESETALWCWEVRDLKVIPLRMRGPLSTRRTARKKIHERITAIYSTLSVLEAPGAEAQVNDMRKASLKLSKALNLEGIKSLVERATQKSNIERGAKNTGSTAKEPMQEMVKSNNDTGIIENVDDSQLQKNTSTNEKDTQKAQKQVEKELKQKEKEEARMRKQQKKQQEEALREQKRREKEEAEMKKQQRKQEEEAQKEQKRREKEEAETRKQQKKQQEEAEKEQKRREKEAVQLKKQLAIQKQASMMERFFKNKKDSEKLEKPGGKDSGVQTTDPCTTNKEVVPLVTSIIDSSFSQKENWALEDLRRLQISGWQKLSSYNRSSRWGIRNKPKKEAFKELKLQKTSDNMLEEILSPNEDTCHNLSQENEPDKSANDVDMLPAVELQFHGTNHANPLPTRSIKRKLLQFDKSNRPAYYGTWRKKSAVVGPRCPLKMDPDLDYEVDSDDEWEEEDPGESLSDCEKDNDEVMEEDSKITDEESEDSFFVPDGYLSDNEGIQIESLLDDKDEASSSPPDQCAEVEEFRALLRQQKVLNTLTEQALRKSQPLVISNLTHEKAELLTAGDLKGTSKIEQLCLQVLSMRICPGGATIDLPVIDSSSANAEETNQLNVKSSPAAASAIPDTDLAEIVKVIGSCRDGINKLVESLHQKFPNVSKSQLKNKVREISEFVDNRWQVKKEVLSKLGLSSSPASSKKPKSIATYFSKRCLPPEEAILASPELRLKSKTTQNVNGDTDIPRINLLPSSQ
Protein: Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (O14522)
Organism: Homo sapiens (Human)
Function: May be involved in both signal transduction and cellular adhesion in the CNS.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- 6-pyruvoyl tetrahydrobiopterin synthase
Sequence:
MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
Protein: Probable multidrug resistance protein EmrK (P52599)
Organism: Escherichia coli (strain K12)
Function: Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs.
Subcellular location: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}; Periplasmic side {ECO:0000305}.
Interaction partners:
- Probable multidrug resistance protein EmrY
- Outer membrane protein TolC
- Multidrug export protein EmrB
- Multidrug resistance protein MdtA
- Probable aminoglycoside efflux pump
- Multidrug efflux pump subunit AcrB
- HTH-type transcriptional regulator YdeO
- Multidrug efflux pump subunit AcrA
- Multidrug resistance outer membrane protein MdtP
- Multidrug resistance protein MdtE
Sequence:
MEQINSNKKHSNRRKYFSLLAVVLFIAFSGAYAYWSMELEDMISTDDAYVTGNADPISAQVSGSVTVVNHKDTNYVRQGDILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSAEVASARIQYQQSLEDYNRRVPLAKQGVISKETLEHTKDTLISSKAALNAAIQAYKANKALVMNTPLNRQPQVVEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQSLMAVVPARQMWVNANFKETQLTDVRIGQSVNIISDLYGENVVFHGRVTGINMGTGNAFSLLPAQNATGNWIKIVQRVPVEVSLDPKELMEHPLRIGLSMTATIDTKNEDIAEMPELASTVTSMPAYTSKALVIDTSPIEKEISNIISHNGQL
Protein: Flagellum transition zone component (Q38AB3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQSGVGNITTPTSPQQLVVEAPAELLETCGVQYPAAADVNEGEVVDSKALSAAPGERDVLGCGPTLLSLLYSTQKKDEVGHRAVTPMLWECNGAQERCHSSKRDFTTCVKARKSPPPGSATGSGTGAIRDVLRPYRESHSKRFRAKVVDCRAALSVDDQIITLKNENAKYKAQLLTKDVQLKELEAALRAFRAPRVPVPSGVTEPAEVGGCYNGTDTEVARLTRENGEVWRRLQQSHAQLAVWKRDARVSKLQELKMELAVYQAEVARLAAEVPSSGGAGGAQNHPARSKLQREAETSRAKDLFIAELKERASENATALRKCMDDAMRTKSTLEQVREENELISKELCLFRKTALALTRVQEELRATQCELAEARERLQAFEQMMHTVGGPEEVKAVVKERDALLTLLKQHNAREAAYHQEFFTRQREMKESMERCLQEAVQQERALAQDREMQLRRSCLMWKERCERLLPDKLFEQGRLIEGGGTVVEDEEQQTELHQLPKKIVTPFMDNSQRQRLLTKHIDDVLIVRQVSSTSTPASSSTTLSPVSGLSKLSITDTTQSQSSSHGMQISHPGNEDASSPVKGNVMSSQKGSSGDAPVPPTERTDPDGGAVSYPASSAVISAERTSLVENSKGDIVTSISTEEGAVQLPRGLMTAGVDSSDDSGSELSDLAVGIEEGKTPSFRLHGNSDGQLIPEVVSRMPLTLRTVSSDGVAAVLTVASPPPRVSVPPAPVPRESAGSIASSENKLSDVNVAVPPPRVSVPPAPVPRESAGSIASSENELSDVNVAVPPPRVSVPPAPVPRESAGSIASSENELSDVNVAVPPPRVSVPPAPVPRESAGSIASSENELSDVNVAVPPPRVSVPPAPVPRESAGSIASSENKLSDVNVAVPPPRVSVPPAPVPRESAGSIASSENELSDVNVAVPPPRVSVPPAPVPRESAGSIASSENKLSDVNVAVPPPRVSVPPAPVPRESAGSIASSENKLSDVNVAVPPPRVSVPPAPVPRESAGSIASSENELSDVNVAVPPPRVSVPPAPVPRESAGSIASSENELSDVNVAVPPPRVSVPPAPVPRESAGSIASSENKLSDVNVAVPPPRVSVPPAPVPRESAGSIASSENKLSDVNVAVPPPRVSVPPAPVPRESAGSIASSENKLSDVNVAVPPPRVSVPPAPVPRESAGSIASSENELSDVNVAVPPPRVSVPPAPVPRESAGSIASSENELSDVNVAVPPPRVSVPPAPVPRESAGSIASSENKLSDVNVAVPPPRVSVPPAPVP
Protein: Protein TUNAR (pTUNAR) (Beta cell and neural cell-regulin) (BNLN) (TCL1 upstream neural differentiation-associated RNA) (A0A1B0GTB2)
Organism: Homo sapiens (Human)
Function: In neurons, plays a role in the regulation of intracellular Ca(2+), possibly by acting as an activator of ATP2A2/SERCA2, thus increasing the efficiency with which Ca(2+) is removed from the cytoplasm (By similarity). Inhibits differentiation of embryonic stem cells into neurons and inhibits neurite outgrowth, likely as a result of its role in intracellular Ca(2+) regulation (By similarity). In pancreatic beta cells, lowers Ca(2+) levels in the endoplasmic reticulum and enhances glucose-stimulated insulin secretion.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:34513312}; Single-pass membrane protein {ECO:0000255}. Extracellular vesicle membrane {ECO:0000250|UniProtKB:A0A1B0GQX2}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MVITSENDEDRGGQEKESKEESVLAMLGIIGTILNLIVIIFVYIYTTL
Protein: Fiber-specific MADS protein (G0X3E3)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRGRVQLKRIENKINRQVTFSKRRSGLLKKAHEISVLCDAQVALMVFSSKGKLFEYATESCMERILERYERYSFTEIQCATDEIQQNGNWTWEHAKLKARMETLQRNLRINLWLNQFLSFRKRTKNCKNRITYLQRRRRRKLMWSRHIGS
Protein: Myelin basic protein (MBP) (Myelin A1 protein) (P04370)
Organism: Mus musculus (Mouse)
Function: The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function.
Subcellular location: [Isoform 13]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 12]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 11]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 10]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 9]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 8]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 7]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 6]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 5]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 4]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.
Interaction partners:
- Myelin proteolipid protein
- Calmodulin-like protein 4
- Myelin-associated glycoprotein
- Calmodulin-4
- Calmodulin-like protein 3
- Calmodulin 5
- Myelin-oligodendrocyte glycoprotein
- 2',3'-cyclic-nucleotide 3'-phosphodiesterase
- Glial fibrillary acidic protein
- Myelin-associated oligodendrocyte basic protein
Sequence:
MGNHSGKRELSAEKASKDGEIHRGEAGKKRSVGKLSQTASEDSDVFGEADAIQNNGTSAEDTAVTDSKHTADPKNNWQGAHPADPGNRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDPTAASGGLDVMASQKRPSQRSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFSGDRGAPKRGSGKDSHTRTTHYGSLPQKSQHGRTQDENPVVHFFKNIVTPRTPPPSQGKGGRDSRSGSPMARR
Protein: Maturase (Q5QJU0)
Organism: Oryza eichingeri
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Interaction partners:
Sequence:
PFDKPRNISLSLIQVEIQMEKFEGYSEKLKFPRQYFVYPLLFQEYIYVFAHDYGLNGSELVEIFGSNNKKFSSLLVKRLMIRMYQQNFWINLVNRPNQDRLLDYNNYFYSEFYSQILSEGFAIVVEIPFSLREQSCPEEKEIPKFQNLRSIHSIFPFLEDKFLHLHYLAHIEIPYPIHLDILLQLLQYRIQDVPSLHLLRFFLNYYSNWNSFITSMKSIFILKKENKRLFRFLYNSYVSEYEFFLLFLRKQSSCLRLTSSGTFLERIHFSRKMEHFGVMYPAFFRKTIWFVMDPLMHYVRYQGKAILASKGTLLLKKKWKCYLVRLWQYSFSFWTQPQRIHLNQLANSCFDFLGYFSSVPINSLLVRNQMLENSFLIDTQMKKFDTKVPVTPLIGSLAKAQFCTGSGHPISKPIWTDLSDWDILDRFGRICRNLFHYHSGSSKKKTLYRLKYILRLSCARTLARKHKSTVRAFMQWLGSVFLEEFFTEEEQVFSLMFAKTTYFSFRGSHSERIWYS
Protein: Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) (SynDIG4) (O35449)
Organism: Mus musculus (Mouse)
Function: Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression.
Subcellular location: Cell membrane {ECO:0000305|PubMed:22632720}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6MG82}. Synapse {ECO:0000305|PubMed:22632720}.
Interaction partners:
- Constitutive coactivator of PPAR-gamma-like protein 2
Sequence:
MSSEKSGLPDSVPHTSPPPYNAPQPPAEPPIPPPQTAPSSHHHHHHHYHQSGTATLPRLGAGGLASAAASAQRGPSSSATLPRPPHHAPPGPAAGAPPPGCATLPRMPPDPYLQETRFEGPLPPPPPAAAAPPPPAPAPTAQAPGFVVPTHAGAVGTLPLGGYVAPGYPLQLQPCTAYVPVYPVGTPYAGGTPGGPGVTSTLPPPPQGPGLALLEPRRPPHDYMPIAVLTTICCFWPTGIIAIFKAVQVRTALARGDLVSAEIASREARNFSFISLAVGIAAMVLCTILTVVIIIAAQHHENYWDP
Protein: Southpaw (Q7ZZT5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MQPVIACASFALFVLRVVDCVWIDKNGAFIKDHRTAFFGAYSSQFYPRYPLYMMQLYRDFSGNKMLTTPASVDNPALHQSDFVLSLIAQDCHQTEERWTVSFDMSSLSASDNIQLSELRIRLPAFSASRRVTVDIFHQHKQHCASDSVFCRNKKLFLGSVKSVDVSQSSSSWRVFNITELLQQWLIQGMDTPDRVTAPDYDQGSGSGSGDDFIESLTSSWPRKIQHPTAERVMIVVFYKETVTHSASSLMNTVAQSKYVTLNRPADGTQGRRHKRNRVERMRMTDDRNVTGKPTPSEEQQASLCRRVDMWVDFDQIGWDEWIVHPKRYNAYRCEGECPSPLDETYNPTNHAYMQSLLKLYQPERVSCPSCVPLRLSSLSMLYYEGDGVVMRHHEDMIVEECGCH
Protein: Eukaryotic translation initiation factor 4C (Q4V9N9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI
Protein: Plastocyanin minor isoform, chloroplastic (P11490)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I. Seems to be a minor plastocyanin in Arabidopsis.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:11719511}; Peripheral membrane protein {ECO:0000269|PubMed:11719511}; Lumenal side {ECO:0000269|PubMed:11719511}. Note=Loosely bound to the inner thylakoid membrane surface in chloroplasts.
Interaction partners:
- Photosystem I reaction center subunit III, chloroplastic
- Photosystem I reaction center subunit V, chloroplastic
- Photosystem I reaction center subunit XI, chloroplastic
- Photosystem I reaction center subunit psaK, chloroplastic
- Plastocyanin major isoform, chloroplastic
- Ferredoxin-2, chloroplastic
- Cytochrome b6-f complex iron-sulfur subunit, chloroplastic
- Oxygen-evolving enhancer protein 2-1, chloroplastic
- Oxygen-evolving enhancer protein 1-1, chloroplastic
- Oxygen-evolving enhancer protein 3-1, chloroplastic
Sequence:
MAAITSATVTIPSFTGLKLAVSSKPKTLSTISRSTSATRAPPKLALKSSLKDFGVIAVATAASIVLAGNAMAMEVLLGSDDGSLAFVPSEFTVAKGEKIVFKNNAGFPHNVVFDEDEIPSGVDASKISMDETALLNGAGETYEVTLTEPGSYGFYCAPHQGAGMVGKLTVK
Protein: LisH domain-containing protein (O62505)
Organism: Caenorhabditis elegans
Interaction partners:
- Cilia- and flagella-associated protein 157
- Protein CASP
- Ectopic P granules protein 2
Sequence:
MSDSNTPNPPGTEERLVQQLDSYFSNTATGNETGEASAPAAPNNAAGTSDQDRPPNLAPILMLSYLNHCMSKKSFTPEDIQKSVWEQKSKKLSQEDWEFCKYFISSKELLLQLAPGKKRKTQAQALIELILKKFPGVGVEMLTRLLDPSESAYIIYDVIEQVKCEPKCDAESIKQEEFMYSQKINKKIRENNKCFKFSMVFERLRNGSSLPEEKPFAPLEFRTITSEYSNIYTQMVKATTYVELMDVMSKLKTTRLSVNELYFSAKHMQNPEKDTQDEFWEAESEKVLELQPLMIDPQLESTSRQRLKILQELALQQKMLKEVDEIISMSFELVTKSLSTGNPHNPADVQSLMINSNAPSIPDQRKNDWMEYYNLNPLGQYPISSHFPRSDRIGPKLPAVIQKISIRYCLSKEIEVIETIDEWKCREFCTYDHNLKDFRRHKCEICEVEVQECDLSLRQTKWCSHIEDQVLLMYNRVNGRLEQYVFSFETKGFKEVYCSCIEVTYRGKNGPEEPVLLTNGSEHVVIKEADPGVVKLQLVGENHVEIPAVPVQQLSAEEIEMQDAYDSSSESGSESEVESESDSESESESEHESEQISYNKTFISTLPMFKVRHCPLSRKDVLYVRSNNLGQYEKYDYHPTYHRFEPFKCSKCKDATSEDHLVPKYAEHCPETNEFVIHTENLFTERMEQYIYDSMTQGFRQVYYPQFLYDPSKDHTSNVFVTVNYLSTVITRDKDGRFKKEKFCDNLKKFVAIPEVEVNTFTVQELEKKKNKRRVDSDSDSFEHIEIPDMVSASP
Protein: Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR) (Q9NUK0)
Organism: Homo sapiens (Human)
Function: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
Subcellular location: Nucleus {ECO:0000269|PubMed:11929853}. Cytoplasm {ECO:0000269|PubMed:11929853}. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
Interaction partners:
- CCHC-type zinc finger nucleic acid binding protein
- CUGBP Elav-like family member 1
- Chloride channel protein 1
- KH domain-containing RNA-binding protein QKI
- Myotonin-protein kinase
- Muscleblind-like protein 1
Sequence:
MTAVNVALIRDTKWLTLEVCREFQRGTCSRADADCKFAHPPRVCHVENGRVVACFDSLKGRCTRENCKYLHPPPHLKTQLEINGRNNLIQQKTAAAMFAQQMQLMLQNAQMSSLGSFPMTPSIPANPPMAFNPYIPHPGMGLVPAELVPNTPVLIPGNPPLAMPGAVGPKLMRSDKLEVCREFQRGNCTRGENDCRYAHPTDASMIEASDNTVTICMDYIKGRCSREKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAATTPATSVPFAAPTTGNQLKF
Protein: H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) (O60832)
Organism: Homo sapiens (Human)
Function: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Subcellular location: [Isoform 1]: Nucleus, nucleolus {ECO:0000269|PubMed:10556300, ECO:0000269|PubMed:10591218, ECO:0000269|PubMed:12429849}. Nucleus, Cajal body {ECO:0000250|UniProtKB:P40615}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21820037}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit 2
- Telomerase reverse transcriptase
- H/ACA ribonucleoprotein complex subunit 3
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- Telomerase Cajal body protein 1
- Nucleolar protein 58
- Protein SHQ1 homolog
- H/ACA ribonucleoprotein complex subunit 1
- Nucleolar protein 56
- rRNA 2'-O-methyltransferase fibrillarin
Sequence:
MADAEVIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEYVDYSESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAKAGLESGAEPGDGDSDTTKKKKKKKKAKEVELVSE
Protein: Keratin, type I cytoskeletal 24 (Cytokeratin-24) (CK-24) (Keratin-24) (K24) (Type I keratin-24) (Q6IFX1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MFCSAQKGSCSSRVSSSGAVGSRGCTGSGSSYGLGGGSAWGFQGSSSSWGLSGGSKGSIGGGFSSCSVRGGFGAGSSFGGGSGFGGGSSGGVSSYGGSLGGGLGGIGGYDGGLLSGSEKQTMQGLNDRLANYLDKVRALEEANTDLETKIKDWYGRHGSGKDGPGRDYSQYCSVIEDLKNQIISATCENARLALQIDNARLAADDFRMKYEHELCLRQSLEADINGLRKVLDEMTMTRCDLEMQIEGLTEELVFLRKNHEEEMKCLQGSSGGDVTVEMNATPGTDLTKLLNDMRAQYEAMAEQNRQEAEKQFNERSACLQAQISTDAGAANCAKSEVMELRRTVQTLEIELQSQLALKCSLEGTLADTEARYVAQLSGIQTQISSLEEQLSQIRGETQCQSAEYECLLDIKTRLEQEIETYRRLLNGDGGGCDYRNLVSRQVVLNDSNFGSCSGQEKDPSKTRVTKTIIEEVVDGKVVSSQVSNISEVKIK
Protein: ABRE binding factor 4 (F4JB53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGTHINFNNLGGGGHPGGEGSSNQMKPTGSVMPLARQSSVYSLTFDELQNTLGGPGKDFGSMNMDELLKSIWTAEEAQAMAMTSAPAATAVAQPGAGIPPPGGNLQRQGSLTLPRTISQKTVDEVWKCLITKDGNMEGSSGGGGESNVPPGRQQTLGEMTLEEFLFRAGVVREDNCVQQMGQVNGNNNNGFYGNSTAAGGLGFGFGQPNQNSITFNGTNDSMILNQPPGLGLKMGGTMQQQQQQQQLLQQQQQQMQQLNQPHPQQRLPQTIFPKQANVAFSAPVNITNKGFAGAANNSINNNNGLASYGGTGVTVAATSPGTSSAENNSLSPVPYVLNRGRRSNTGLEKVIERRQRRMIKNRESAARSRARKQAYTLELEAEIEKLKKTNQELQKKQAEMVEMQKNEQLKETSKRPWGSKRQCLRRTLTGPW