wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein kinase akt-1 (EC 2.7.11.1) (Protein kinase B akt-1) (PKB akt-1) (Q17941)
Organism: Caenorhabditis elegans
Function: Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Plays a role in maintaining the gonadal basement membrane through it's role in inhibiting daf-16 activity. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development.
Interaction partners:
- Forkhead box protein O
- Phosphatidylinositol 3-kinase age-1
- 3-phosphoinositide-dependent protein kinase 1
- Phosphoinositide 3-kinase adapter subunit
- DAF-15
- Target of rapamycin homolog
- Protein skinhead-1
- Glycogen synthase kinase-3
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
- Serine/threonine-protein kinase akt-2
Sequence:
MSMTSLSTKSRRQEDVVIEGWLHKKGEHIRNWRPRYFMIFNDGALLGFRAKPKEGQPFPEPLNDFMIKDAATMLFEKPRPNMFMVRCLQWTTVIERTFYAESAEVRQRWIHAIESISKKYKGTNANPQEELMETNQQPKIDEDSEFAGAAHAIMGQPSSGHGDNCSIDFRASMISIADTSEAAKRDKITMEDFDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQRCKHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISFGDKTSTFCGTPEYLAPEVLDDHDYGRCVDWWGVGVVMYEMMCGRLPFYSKDHNKLFELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGPEDALEICRADFFRTVDWEATYRKEIEPPYKPNVQSETDTSYFDNEFTSQPVQLTPPSRSGALATVDEQEEMQSNFTQFSFHNVMGSINRIHEASEDNEDYDMG
Protein: Homeobox protein YHP1 (Q04116)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional repressor required to restrict transcription of ECB-dependent genes to the G1/M phase by repressing their transcription during S late phase. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. Binds the IMEI regulatory region in vitro, its relevance in vivo is however unclear.
Subcellular location: Nucleus.
Interaction partners:
- Pheromone receptor transcription factor
- Homeobox protein YOX1
- Forkhead transcription factor HCM1
- Cyclin-dependent kinase 1
- Regulatory protein SWI4
- Fork head protein homolog 1
- Fork head protein homolog 2
- Transcription factor MBP1
- Transcriptional factor SWI5
- Morphogenetic regulator of filamentous growth protein 1
Sequence:
MESRNTVLPSLPNIITGTSNSPFQLHTLPNTNFPSDDQGDIRLPPLAASAHIVRPVVNIYKSPCDEERPKRKSPQAVDFLSQRVTTSMTPLSKPKKLSSHSPFTPTVRVCSKEQPPQSMHSYKKVNILTPLSAAKAVLTPTTRKEKKRSFAFITHSQETFPKKEPKIDNARLARRKRRRTSSYELGILQTAFDECPTPNKAKRIELSEQCNMSEKSVQIWFQNKRQAAKKHKNSGNTSHCKVHSNDSMSMISYSDAALEITSTPTSTKEAITAELLKTSPANTSSIFEDHHITPCKPGGQLKFHRKSVLVKRTLSNTGHSEIIKSPKGKENRLKFNAYERKPLGEVDLNSFKN
Protein: 6-aminohexanoate-dimer hydrolase (EC 3.5.1.46) (6-aminohexanoic acid linear oligomer hydrolase) (Nylon oligomers-degrading enzyme EII) (P07061)
Organism: Paenarthrobacter ureafaciens
Function: Involved in nylon oligomer degradation.
Interaction partners:
Sequence:
MNARSTGQHPARYPGAAAGEPTLDSWQEAPHNRWAFARLGELLPTAAVSRRDPATPAEPVVRLDALATRLPDLEQRLEETCTDAFLVLRGSEVLAEYYRAGFAPDDRHLLMSVSKSLCGTVVGALIDEGRIDPAQPVTEYVPELAGSVYDGPSVLQVLDMQISIDYNEDYVDPASEVQTHDRSAGWRTRRDGDPADTYEFLTTLRGDGGTGEFQYCSANTDVLAWIVERVTGLRYVEALSTYLWAKLDADRDATITVDQTGFGFANGGVSCTARDLARVGRMMLDGGVAPGGRVVSQGWVESVLAGGSREAMTDEGFTSAFPEGSYTRQWWCTGNERGNVSGIGIHGQNLWLDPRTDSVIVKLSSWPDPDTRHWHGLQSGILLDVSRALDAV
Protein: Omega-hexatoxin-Hv1a (Omega-HXTX-Hv1a) (Omega-atracotoxin-Hv1a) (Omega-ACTX-Hv1) (Omega-AcTx-Hv1a) (Omega-atracotoxin-Hv1) (Omega/kappa-atracotoxin-Hv1a) (Omega/kappa-HXTX-Hv1a) (P56207)
Organism: Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Function: Reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels in cockroach DUM neurons. Is lethal to many insect species but not toxic to mammals. May target the insect high-voltage-activated calcium channel Dmca1D. Also inhibits acarines calcium channels. An extremely high toxin concentration partially inhibits Cav1.2/CACNA1C, Cav2.1/CACNA1A and Cav2.2/CACNA1B calcium channel of rats. As for omega-AcTx-Hv2a, the phenotypic effect of injection of this toxin into lone star ticks (Amblyomma americanum) is curling of all eight legs into closed loops.
Subcellular location: Secreted {ECO:0000269|PubMed:9228949}.
Interaction partners:
Sequence:
SPTCIPSGQPCPYNENCCSQSCTFKENENGNTVKRCD
Protein: POTRA domain-containing protein (Q9HVG7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004442}.
Interaction partners:
- Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS domain-containing protein
- Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS domain-containing protein
- ShlB/FhaC/HecB family hemolysin secretion/activation protein
- Adhesive protein CupB5
- Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS domain-containing protein
- ShlB/FhaC/HecB family hemolysin secretion/activation protein
- TIGR01459 family HAD-type hydrolase
- POTRA domain-containing protein
- Uncharacterized protein
- POTRA domain-containing protein
Sequence:
MKPSQWTLRWVTLCGCGMLAASAAAVELPGTVQPSQLDERFKPRSEPQAKPEAPLVVPKQVAPQGSEQIRFKLREIRIEGNTRYDKAVLESYYQHMLGEQVSLAELVDLANRLTAKYRQDGFLLTQVVVPEQSIEGGKVRLQVIEGYLEHVQIKGTVDGPRVRVEELLAPLTEKRPLDADTLERGLLLVGDLPGVNVQSVLSPGQALGSSNLDVALQQQRYEGFVSLDNRGSHYTDPTTLAFGATEFSRLGFYEQIDVLGAISPFSDATRYIQLRGTLPLGGMFAGDTLQIMGSYSKVNPDIPDSVFPFDSVSKSTEGSISYNHPFIRSRSQNLSGGLALQWKDTETRLRDFASDASNPGRDHVRVFQQRLTYDWVDRWMGINLAEVRNNIGLDMWGATKKDDERRSREVADGRFVYLNGNIGRLQGLGGPWSVYGELQWQYSFDPLLPSERFGVGGSGIGRGFAPGNITGDRGFALKLEPRYGQAVGYSWLRSYQAYAFYDWGKTYNLDVDDDEQQKLGSIGAGVRFNLTDQLSFNPEIARQVIGEPADQRDGKRETRVLFNVVARF
Protein: Uncharacterized protein unannotated coding sequence from BAC F9L11 (Q94K21)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA polymerase epsilon catalytic subunit A
- Proline-rich extensin-like family protein
- AT3g10020/T22K18_16
- Proline-rich extensin-like family protein
- Proline-rich extensin-like family protein
- Adenine phosphoribosyltransferase 5
- Enoyl-CoA delta isomerase 3
- Glutathione S-transferase U27
- Adenine phosphoribosyltransferase 3
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Sequence:
MLLVTLIAEMMKEYTVVLAGVVEHLFSQAPFPRRIRLHILYSLPFHSSNTSLPLLLPSPPPYSRSS
Protein: Ribonucleoside-diphosphate reductase subunit alpha (EC 1.17.4.1) (Protein B1) (Ribonucleotide reductase) (P32282)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Interaction partners:
Sequence:
MQLINVIKSSGVSQSFDPQKIIKVLSWAAEGTSVDPYELYENIKSYLRDGMTTDDIQTIVIKAAANSISVEEPDYQYVAARCLMFALRKHVYGQYEPRSFIDHISYCVNAGKYDPELLSKYSAEEITFLESKIKHERDMEFTYSGAMQLKEKYLVKDKTTGQIYETPQFAFMTIGMALHQDEPVDRLKHVIRFYEAVSTRQISLPTPIMAGCRTPTRQFSSCVVIEAGDSLKSINKASASIVEYISKRAGIGINVGMIRAEGSKIGMGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVENLLVLKNNKGVEENRIRHMDYGVQLNDLMMERFGKNDYITLFSPHEMGGELYYSYFKDQDRFRELYEAAEKDPNIRKKRIKARELFELLMTERSGTARIYVQFIDNTNNYTPFIREKAPIRQSNLCCEIAIPTNDVNSPDAEIGLCTLSAFVLDNFDWQDQDKINELAEVQVRALDNLLDYQGYPVPEAEKAKKRRNLGVGVTNYAAWLASNFASYEDANDLTHELFERLQYGLIKASIKLAKEKGPSEYYSDTRWSRGELPIDWYNKKIDQIAAPKYVCDWSALREDLKLFGIRNSTLSALMPCESSSQVSNSTNGYEPPRGPVSVKESKEGSFNQVVPNIEHNIDLYDYTWKLAKKGNKPYLTQVAIMLKWVCQSASANTYYDPQIFPKGKVPMSIMIDDMLYGWYYGIKNFYYHNTRDGSGTDDYEIETPKADDCAACKL
Protein: Frizzled-6 (Fz-6) (mFz6) (Q61089)
Organism: Mus musculus (Mouse)
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity). Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear.
Subcellular location: Membrane {ECO:0000269|PubMed:10097073}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10097073}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:16495441}. Apical cell membrane {ECO:0000269|PubMed:16495441}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16495441}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:31073040}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with FZD3 at the apical face of cells (PubMed:16495441). Localizes to the endoplasmic reticulum membrane in the presence of LMBR1L (PubMed:31073040). {ECO:0000269|PubMed:16495441, ECO:0000269|PubMed:31073040}.
Interaction partners:
- Protein Wnt-11
- Protein Wnt-5a
- Protein Wnt-4
- Proto-oncogene Wnt-1
- Tyrosine-protein kinase RYK
- Low-density lipoprotein receptor-related protein 6
- Low-density lipoprotein receptor-related protein 5
- Protein Wnt-5b
- Protein Wnt-7a
- Protein Wnt-16
Sequence:
MERSPFLLACILLPLVRGHSLFTCEPITVPRCMKMTYNMTFFPNLMGHYDQGIAAVEMGHFLHLANLECSPNIEMFLCQAFIPTCTEQIHVVLPCRKLCEKIVSDCKKLMDTFGIRWPEELECNRLPHCDDTVPVTSHPHTELSGPQKKSDQVPRDIGFWCPKHLRTSGDQGYRFLGIEQCAPPCPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFVGFLLGNSTACNKADEKLELGDTVVLGSKNKACSVVFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGAPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYELVNRITWEMTWFSDHCHQYRIPCPYQANPKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHGAPGPHRLKVISKSMGTSTGATTNHGTSAMAIADHDYLGQETSTEVHTSPEASVKEGRADRANTPSAKDRDCGESAGPSSKLSGNRNGRESRAGGLKERSNGSEGAPSEGRVSPKSSVPETGLIDCSTSQAASSPEPTSLKGSTSLPVHSASRARKEQGAGSHSDA
Protein: Nopp140, isoform B (Q7KTV5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTDLLKIADAIVLEYLQSKDKNLAKVFQQKTKAASVAKSSPKLSEILQFYQTKSPKKIPAIKATAGDSSEDSDSDSESDAAPKKPATAPALTNGKAVKKAASSTSEDSDSEEEKKPAAKATPAKAVGKKAKSSSEDSSSEEEAPKKAAPVKAPPAKAAPAKKVESSSEDSSSEEEPAKPAVKATTTKVAPAKKADSSSEESSSDEETKPAAKPVAKAAPAKKAASSSEESDSDDEPAAKKPAVQPAAKPAPKAAASSSEDSSSEEEVKPAAKSAAKLAPAKKGASSSDDSSSEDEAPKKAATLAKPISKAAPTKKADSSTEDSSSEDDAPKKVAPAKATPAKAIPAKKAASSDDSSSEEEAPKKAAPANATPARAPPAKKAASSDDSSSEEEAPKKAAPAKATPAKATPAKKAASSDDSSSEEEAPKKAAAPAKATPAKKAKSSSEDSDSDEEEAPKKPAAKAVAKAASSEDSDSSEDEKPAKAAPKALAKSAKAASSDSDDSSDEETPAVKPAVKKTAAPAKKADSSSDESDSGEESGEVKPNSATNGNEKTAQKRKFSGGDQDEATPNKKYNNFVKSGEQQKNDFTSTPNNTFSRNHNMNNSGGGSGRRSPFRRVRTEDVVVDSRVQDMSFEAKKNAAGSWGERANKDLKHTRGKSFKHEKTKKKRGSYRGGQIDVGVNSIKFD
Protein: Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (N-acetyl-beta-glucosaminidase subunit beta) (F1QUU0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000256|ARBA:ARBA00037865}. Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
Sequence:
MLCLLKFTPLFLVVAVCHGWLFGDLFEKQKELDEISLWPLPQKYQSSAVAFKLSAASFQIVHAKQSTAGPSCSLLENAFRRYFEYMFGELKRQEKSRKKAFDSDLSELQVWITSADPECDGYPSLRTDESYSLSVDETSAVLKAANVWGALRGLETFSQLVYEDDYGVRNINKTDISDFPRFAHRGILLDSSRHFLPLKVILANLEAMAMNKFNVFHWHIVDDPSFPFMSRTFPELSQKGAYHPFTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGNGIKDLLTPCYSGSSPSGSFGPVNPILNSSYEFMAQLFKEISTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMNQQGFGTDYSKLESFYIQRLLDIVAATKKGYMVWQEVFDNGVKLKDDTVVEVWKGNDMKEELQNVTGAGFTTILSAPWYLDYISYGQDWQRYYKVEPLDFTGQFLQSNSF
Protein: Eukaryotic translation initiation factor 4C (I7MK25)
Organism: Tetrahymena thermophila (strain SB210)
Interaction partners:
- 40S ribosomal protein S15
- 40S ribosomal protein S18, putative
- 40S ribosomal protein S5
- 40S ribosomal protein S15a
- 40S ribosomal protein S23
- 40S ribosomal protein S11, putative
- Small ribosomal subunit protein uS10
- Translation initiation factor SUI1
- Small ribosomal subunit protein uS5
- Ribosomal protein S9 component of cytosolic 80S ribosome and 40S small subunit
Sequence:
MPKNKGRGGKNYRRGKNENETKRELVFKEEGMEYAQVIKMLGNGRLEVFCFDGKRRIGHICGRLKKKVWISMDDIVLVGLRDFQDDKCDILLKYLPDEVRNLKQYGEIDENIKINDKSGADQADVVFEDSDSDDKDDDDDDEDEQPTRQTNTRVNQMVESSDEEDNKETGNYEEQKYDQKHQNKKDDIDIDDI
Protein: Candida glabrata strain CBS138 chromosome M complete sequence (Q6FJ18)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Nucleoporin NSP1
- Candida glabrata strain CBS138 chromosome G complete sequence
- Protein kinase C-like 1
- Candida glabrata strain CBS138 chromosome D complete sequence
Sequence:
MIGGKSSPKSMKNSIGSTLRKWRSTLRKVTHDTLNSLDEVTANEEKIDALFDGEGGKTVNWGPVRTSKNGLVQVHEEDMLEEDVTNDLKSSSFGFEKSTTAQPVGIQGLLKSGSIEQISSGSRSLVGGVGGTSMRLSEESEEGGSTTGTSNKHEQLTIMKSSSGGSQGVSHKEKLTYDNFDAVAECNKLRQRSDKPFVGGPKIWEKRRKLWCEPSVSAEEIAHRRENGRGVFDAIPEAYHTSVYKKLVVDNKPLKEPLNLSHAMKVINAGWIDTKKWANAGKGLP
Protein: Electron transfer flavoprotein subunit alpha (Alpha-ETF) (H0YLU7)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|PIRNR:PIRNR000089}.
Interaction partners:
Sequence:
MFRAAAPGQLRRAASLLRFQSTLVIAEHANDSLAPITLNTITAATRLGGEVSCLVAGTKCDKVAQDLCKVAGIAKVLVAQHDVYKGLLPEELTPLILATQKQFNYTHICAGASAFGKNLLPRVAAKLEVAPISDIIAIKSPDTFVRTIYAGNALCTVKCDEKVKVFSVRGTSFDAAATSGGSASSEKASSTSPVEISEWLDQKLTKSDRPELTGAKVVVSGDGVSLLLPRLECNGTISAHRHLHLPGSSDSPASASRVAGITVETEVLHVGQAGLEILTSGDPPTSASQSVGITGRGLKSGENFKLLYDLADQLHAAVGASRAAVDAGFVPNDMQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADYGIVADLFKVVPEMTEILKKK
Protein: Dynein regulatory complex protein 1 (P0DL09)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23354437}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337, ECO:0000269|PubMed:29167384}.
Interaction partners:
Sequence:
MDELQSQTEREARILARRKRIQERLAALREGDHGGGKEGENKEEIGKGKQQIIESKRRLMRVKYRTDQDVSSVRVAGDDRENQHRIQEEQTRQDLRAKLLAEAEQSARQNAAVAMRWADLFSIEVPQDLYNEIESQRQACERIIASKDKLIGEIKGELKKKDDEFVKTLKRQAEDIDTLLQYMSRQFVEVQNAYKEELDEIENAFLQERSDLLESNRREMQELFDKRSRLEQDFMDRYLAAVEAYQSQLEGHRQMDAEEYHILKIRLETDIQNLEQHLEAMRATYQLNTEKLEYNYRVLKEREKENTQTIESQKKKLSRQRDILSSLKQRYAETDRRYRDDNMKLTDEYKRITEQFKDLQSKFRHFELVDTKKYKEVWGMKEADVAALVRQLLQADKVLHEQQLGWDWRPPDDAVFAPVHGDAGSGGGAAAAATGGAAGGAAAAGGVGPNGEEESEEDAAARVREAELAERLRDGRNWGALGLLCDEAGFLIDIKARNMIERLPKDEQGQVKAEAILRSLGIADGSAFDALLEALSADSNIELRAKGMVAPQGRGMAEEKSDRGGTAVLVHPDEAVRRLKAFVEVYGTGPSRGPGGGGGGGGGMSGPMRVQGAMRRAAEREQEFWSRMTHVISDKHTRVWGALEKQLEKYLALLQERAGSLRDVESLQHQNNELRALLNQYLSSRINDELQIPPTQII
Protein: Rab4 protein (Rab4, isoform A) (Rab4, isoform B) (Q7KY04)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
- LD29542p
- LD23155p
- FI04439p
- non-specific serine/threonine protein kinase
- Ras-related protein Rab5
- Rabaptin-5-associated exchange factor for Rab5
- Vacuolar protein sorting-associated protein 35
- Ras-related protein Rab6
- Rab proteins geranylgeranyltransferase component A
Sequence:
MSETYDYLFKFLIIGSAGSGKSCLLHHFIESKFKDDSSHTIGVEFGSRIVNVGGKSVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASPNIVILLVGNKKDLEEARDVTFLEASTFAQENELIFLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQYGGAALRNLQTRQRSINKPDCTCRV
Protein: GH07829p (Neuroligin 4, isoform D) (B6IDZ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Esterase P
- Esterase-6
- Beta-glucuronidase
- Beta-glucuronidase
- Cytidine deaminase
- cytidine deaminase
- Cytidine deaminase
- Neurexin 1, isoform F
- UDP-glycosyltransferase family 37 member A2
Sequence:
MGESQLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTTLANASSDTLASGFEAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPEPIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLLQAAAAAAAAAANDVKPPPPHICSNTGMQQQQQVGGGSGGALNNGGIEGSKVTTDNLGNVTYSTSSKQQQQHQQQQQQQQREHMQIKGMTGTQTFGRSGSGSGGGAGGGAGSASGGASVVVSGSSVSYNPGMMTLPKSGGLHHAATLNYARNTTALNMSGGGTALVDSRGNVLLTSTAVGPGMAGTGAGGGSSGGGGGGDCMTLPRNLGLAAAGRHNPTTAELQQYQQQQQSSKHQSNGAVLTGMQSHHIRGPRPPLRTASSTTTNSSSNNSAMGVAVGVGGGVGNMLLDQTPSGGSSSSGVSSAPSSSKGHHTHSHSHAAHLVHSHGDGLVLTSASPVGGQQQQHPQQHQHPQQQQQVPQAAMDEMRV
Protein: Large ribosomal subunit protein eL34A (60S ribosomal protein L34-A) (O42846)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL22
Sequence:
MAQRVTYRRRLAYNTRSNRTRIIKTPGNNIRYLHIKKLGTIPRCGDTGVPLQGIPALRPREFARLSHNKKTVQRAYGGCLSANAVKDRIVRAFLIEEQKIVKQKLKQLSSQK
Protein: NAD-dependent protein deacetylase sirtuin-3 (EC 2.3.1.286) (NAD-dependent protein delactylase sirtuin-3) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3) (mSIR2L3) (Q8R104)
Organism: Mus musculus (Mouse)
Function: NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation.
Subcellular location: [Isoform L]: Mitochondrion matrix {ECO:0000269|PubMed:19241369, ECO:0000269|PubMed:19333382, ECO:0000269|PubMed:23283301}.; SUBCELLULAR LOCATION: [Isoform S]: Cytoplasm {ECO:0000269|PubMed:11056054}.
Interaction partners:
- NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
- Forkhead box protein O3
- NAD-dependent protein deacylase sirtuin-5, mitochondrial
- Acetyl-coenzyme A synthetase 2-like, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- Nicotinamide phosphoribosyltransferase
- NAD-dependent protein deacylase sirtuin-6
- NAD-dependent protein deacetylase sirtuin-7
- Superoxide dismutase, mitochondrial
- NAD-dependent protein deacetylase sirtuin-2
Sequence:
MALDPLGAVVLQSIMALSGRLALAALRLWGPGGGRRPISLCVGASGGFGGGGSSEKKFSLQDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLILGTSLEVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLDLMQRERGKLDGQDR
Protein: Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) (P62320)
Organism: Mus musculus (Mouse)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62318}. Nucleus {ECO:0000269|PubMed:19470752}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000250|UniProtKB:P62318}.
Interaction partners:
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein-associated protein B
- U6 snRNA-associated Sm-like protein LSm7
- Pre-mRNA-processing-splicing factor 8
- U1 small nuclear ribonucleoprotein C
- U6 snRNA-associated Sm-like protein LSm3
Sequence:
MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR
Protein: SUMO1 activating enzyme subunit 1 (M0QYM8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRA
Protein: Uncharacterized protein (Q385Z3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHHNEFNSVEMELREIEQDFTSGNMSAFGTPATREGFVRELCKIADIETQIYYKTCGLLNSEASGDHKLRTMMYSTAEPPHGPVTNSSSNNSGTGTPKGQGQRRQSVDLNNSSHDAERSNHVANNSDIGNAMKHSSSSASVPRNSEVPGGMEFDNTVTNQQPLPWRRDAGLTERPFQDISKHFKILEGEFNVIGEHMRQISTHLLRLNEIAEQGKAGSMGIAP