wanglab/gogpt-training-data huggingface dataset:
Protein: Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) (P27615)
Organism: Rattus norvegicus (Rat)
Function: Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:1715871, ECO:0000269|PubMed:1859403}; Multi-pass membrane protein {ECO:0000269|PubMed:1715871, ECO:0000269|PubMed:1859403}.
Interaction partners:
- Thrombospondin-1
- Toll-like receptor 4
- Leukocyte surface antigen CD47
- Toll-like receptor 2
- Toll-like receptor
- CD63 antigen
- Apolipoprotein B-100
- Glucosylceramidase
- Thrombospondin-2
- Tyrosine-protein kinase Lyn
Sequence:
MARCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFDSWEKPPLPVYIQFYFFNVTNPEEILQGEIPLLEEVGPYTYRELRNKANVQFGENGTTISAVTNKAYIFERNQSVGDPTVDLIRTINIPLLTVVEMAQQPFLREIIEAMLKAYQQTLFVTHTVHELLWGYKDEVLSLVHIFRPDVSPNFGLFYERNGTNDGEYVFLTGEDNYLNFTKIVEWNGKTSLDWWTTDTCNMINGTDGDSFHPLISKDETLYIFPSDFCRSVYITFSSFENVEGLPAFRYKVPAEILANSSENAGFCIPEGNCMDAGVLNVSICKNGAPIIMSFPHFYQADEKFVSAIKGMRPNKEEHESFVDINPLTGIILRGAKRFQINTYVKKLDDFVETGNIRTMVFPVMYLNESVLIDKETASQLKSVINTTLIVTNIPYIIMALGVFFGLIFTWLACRGQGSTDEGTADERAPLIRT
Protein: Phenolphthiocerol/phthiocerol polyketide synthase subunit E (EC 2.3.1.292) ((Phenol)carboxyphthiodiolenone synthase subunit E) (Beta-ketoacyl-acyl-carrier-protein synthase I) (Phthiocerol synthesis polyketide synthase type I PpsE) (P9WQE1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the PpsABCDE complex involved in the biosynthesis of the lipid core common to phthiocerols and phenolphthiocerols by successive additions of malonyl-CoA or methylmalonyl-CoA extender units. PpsA can accept as substrate the activated forms of either icosanoyl (C20), docosanoyl (C22) or lignoceroyl (C24) groups from FadD26, or a (4-hydroxyphenyl)-C17 or (4-hydroxyphenyl)-C19 fatty acyl from FadD29. PpsA initiates the biosynthesis and extends its substrate using a malonyl-CoA extender unit. The PpsB and PpsC proteins add the second and third malonyl-CoA extender units. PpsD adds an (R)-methylmalonyl unit and PpsE adds a second (R)-methylmalonyl unit. The incorporation of the methylmalonyl units results in formation of two branched methyl groups in the elongated product.
Interaction partners:
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Phenolphthiocerol/phthiocerol polyketide synthase subunit D
- Doxorubicin resistance ATP-binding protein DrrA
- Phthiocerol/phthiodiolone dimycocerosyl transferase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit A
- Phenolphthiocerol/phthiocerol polyketide synthase subunit B
- Doxorubicin resistance ABC transporter permease protein DrrB
- Long-chain-fatty-acid--AMP ligase FadD26
- Probable doxorubicin resistance ABC transporter permease protein DrrC
- Thioesterase TesA
Sequence:
MSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKESIVTLSEQELRDAGVSDKTLADPAYVRRAPLLDGIDEFDAGFFGFPPLAAQVLDPQHRLFLQCAWHALEDAGADPARFDGSIGVYGTSSPSGYLLHNLLSHRDPNAVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVAVHLACLSLLSGECDMALAGGSSLCIPHRVGYFTSPGSMVSAVGHCRPFDVRADGTVFGSGVGLVVLKPLAAAIDAGDRIHAVIRGSAINNDGSAKMGYAAPNPAAQADVIAEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQGLRAAFEVSQTSRSAPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKALPATLHYTSPNPELRLDQSPFVVQSKYGPWECDGVRRAGVSSFGVGGTNAHVVLEEAPAEASEVSAHAEPAGPQVILLSAQTAAALGESRTALAAALETQDGPRLSDVAYTLARRRKHNVTMAAVVHDREHAATVLRAAEHDNVFVGEAAHDGEHGDRADAAPTSDRVVFLFPGQGAQHVGMAKGLYDTEPVFAQHFDTCAAGFRDETGIDLHAEVFDGTATDLERIDRSQPALFTVEYALAKLVDTFGVRAGAYIGYSTGEYIAATLAGVFDLQTAIKTVSLRARLMHESPPGAMVAVALGPDDVTQYLPPEVELSAVNDPGNCVVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHTSAMDPMLGQFQEFLSRQQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQISSPIRFADELDVVLAAPSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRLMRHPLQDVDDRDTFLRALGELWSAGVEVDWTPRRPAVPHLVSLPGYPFARQRHWVEPNHTVWAQAPGANNGSPAGTADGSTAATVDAARNGESQTEVTLQRIWSQCLGVSSVDRNANFFDLGGDSLMAISIAMAAANEGLTITPQDLYEYPTLASLTAAVDASFASSGLAKPPEAQANPAVPPNVTYFLDRGLRDTGRCRVPLILRLDPKIGLPDIRAVLTAVVNHHDALRLHLVGNDGIWEQHIAAPAEFTGLSNRSVPNGVAAGSPEERAAVLGILAELLEDQTDPNAPLAAVHIAAAHGGPHYLCLAIHAMVTDDSSRQILATDIVTAFGQRLAGEEITLEPVSTGWREWSLRCAALATHPAALDTRSYWIENSTKATLWLADALPNAHTAHPPRADELTKLSSTLSVEQTSELDDGRRRFRRSIQTILLAALGRTIAQTVGEGVVAVELEGEGRSVLRPDVDLRRTVGWFTTYYPVPLACATGLGALAQLDAVHNTLKSVPHYGIGYGLLRYVYAPTGRVLGAQRTPDIHFRYAGVIPELPSGDAPVQFDSDMTLPVREPIPGMGHAIELRVYRFGGSLHLDWWYDTRRIPAATAEALERTFPLALSALIQEAIAAEHTEHDDSEIVGEPEAGALVDLSSMDAG
Protein: Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] (P42574)
Organism: Homo sapiens (Human)
Function: Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis. Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15003516}.
Interaction partners:
- Caspase-8
- E3 ubiquitin-protein ligase XIAP
- Poly [ADP-ribose] polymerase 1
- Caspase-9
- Apoptotic protease-activating factor 1
- Baculoviral IAP repeat-containing protein 2
- Cytochrome c
- Baculoviral IAP repeat-containing protein 3
- Cyclin-dependent kinase inhibitor 1
- DNA fragmentation factor subunit alpha
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Protein: Zinc finger protein AZF2 (Zinc-finger protein 2) (Q9SSW2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor involved in the inhibition of plant growth under abiotic stress conditions. Can repress the expression of various genes, including osmotic stress and abscisic acid-repressive genes and auxin-inducible genes, by binding to their promoter regions in a DNA sequence-specific manner. Acts as a negative regulator of abscisic acid (ABA) signaling during seed germination. Probably involved in jasmonate (JA) early signaling response. May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade. May act as a positive regulator of leaf senescence. Has been identified as a suppressor of the deficiency of yeast snf4 mutant to grow on non-fermentable carbon source.
Subcellular location: Nucleus {ECO:0000269|PubMed:15333755, ECO:0000269|PubMed:21852415}.
Interaction partners:
- Cysteine proteinase inhibitor 2
- C2H2 and C2HC zinc fingers superfamily protein
Sequence:
MALEAMNTPTSSFTRIETKEDLMNDAVFIEPWLKRKRSKRQRSHSPSSSSSSPPRSRPKSQNQDLTEEEYLALCLLMLAKDQPSQTRFHQQSQSLTPPPESKNLPYKCNVCEKAFPSYQALGGHKASHRIKPPTVISTTADDSTAPTISIVAGEKHPIAASGKIHECSICHKVFPTGQALGGHKRCHYEGNLGGGGGGGSKSISHSGSVSSTVSEERSHRGFIDLNLPALPELSLHHNPIVDEEILSPLTGKKPLLLTDHDQVIKKEDLSLKI
Protein: Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Protein LHP1-INTERACTING FACTOR 2) (Q9ASP6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that binds DNA on GAGA-like motif and 5'-(C/G)ACGTG(G/T)C(A/G)-3' consensus motif in the promoters of target genes. Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus (By similarity). Required during flower development and for cell fate determination. Acts both as an antagonist and as a promoter of polycomb LHP1 gene regulation activity, depending of target genes, to regulate the transcription of stress-responsive and flowering genes. May regulate histone H3 trimethylation on lysine 27 (H3K27me3). Recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and acetylated at 'Lys-9' (H3K9ac), leading to epigenetic activation. When in complex with LHP1, recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and 'Lys-27' (H3K27me), mostly corresponding to stress-responsive genes. May function as a suppressor of cell-autonomous immune responses involving glucosinolates, salicylic acid (SA) and jasmonic acid (JA) pathways toward pathogenic bacteria and fungi.
Subcellular location: Nucleus {ECO:0000269|PubMed:21304947}. Cytoplasm {ECO:0000269|PubMed:21304947}. Microsome {ECO:0000250|UniProtKB:Q7TMK9}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250|UniProtKB:Q7TMK9}.
Interaction partners:
- Chromo domain-containing protein LHP1
- F23A5.30 protein
- E3 ubiquitin-protein ligase RKP
- RNA-binding
- Serine/arginine-rich splicing factor SC35
Sequence:
MSDARDNDDRVDFEEGSYSEMEDEVEEEQVEEYEEEEEEDDDDDDVGNQNAEEREVEDYGDTKGGDMEDVQEEIAEDDDNHIDIETADDDEKPPSPIDDEDREKYSHLLSLPPHGSEVFIGGLPRDVGEEDLRDLCEEIGEIFEVRLMKDRDSGDSKGYAFVAFKTKDVAQKAIEELHSKEFKGKTIRCSLSETKNRLFIGNIPKNWTEDEFRKVIEDVGPGVENIELIKDPTNTTRNRGFAFVLYYNNACADYSRQKMIDSNFKLEGNAPTVTWADPKSSPEHSAAAAQVKALYVKNIPENTSTEQLKELFQRHGEVTKIVTPPGKGGKRDFGFVHYAERSSALKAVKDTERYEVNGQPLEVVLAKPQAERKHDPSSYSYGAAPTPAPFVHPTFGGFAAAPYGAMGAGLGIAGSFSQPMIYGRGAMPTGMQMVPMLLPDGRVGYVLQQPGMPMAAAPPQRPRRNDRNNGSSGGSGRDNSHEHDGNRGGRRYRPY
Protein: Uncharacterized protein (Q580J4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MALGGSLLALRKDIWARANKLLRVQRTAAAQTMYYQPSNIVPLRCIAPTAVVGTPYGAYVNQYVSELQAWCRASDEAVVATQKQLQRLAAERERTKYLFRRQLLLFIPITAVAPFFLREYVDRICAERTHEFLRKHAEERCSLKWIAI
Protein: Protein OSCP1a (Zgc:171454 protein) (A8KB18)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSQRTLPLLIINLGGEMIYILDQRLRAPDESDEKTQRGCWTEDDRKRVMNDIVSTMFSKVFLEELLRPQDLYSHRALRTVLTRIAHTSIMRLNPASMDKLYDLMTMAFKYQLVLCPRPQDLLLITFNHTDAIKELVKDNPSLVNQINEAQRLLIEVYTPLSDGELQLIRHTLLLLFQDMQIRVSIFLKEKIQNPNGHFVLQTSGPVPYGFQVPGLIRLFNAKGREVTRTRFPSGGSYTSALNPGSLDLYGDRVTLLGTNMYSTPSPEDMNPSSTNTSRGKPKQADSTPNPLATEELNLLAKLMGGMEVQKLSNVDAAFRVNLLALNQEEESSGTSEGTDQHSSAVINIQATQDELASTELARIAEEFDEEGNQTEELGNKGDDLLAMMDEL
Protein: Reverse transcriptase Ty1/copia-type domain-containing protein (Q2F946)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MDEEYGALMRNNTWHLVPATQGRNLIDCKWVYKIKRKADGTIDRYKARLVAKGFKQRYGIDYEETFSPVVKAATIRLILSLAVSNGWSLRQLDVQNAFLHGVLEEDVYMRQPPGYEDKSKLDYVCKLDKALYGLKQAPRAWFSRLSMKLQNLGFQPSKADASLFFYKKGTISIFVLIYVDDIIVASSCEKATSALLQDLKEEFALKDLGALHYFLGIEVNKVHDGIILTQEKYATDLLKRVGMHGCKEINTPLSTTDKLLAKEGEPLGAEDSTRYRSIVGALQYLTLTRPDIAFPVNKVCQYLHAPTSLHWTAVKRILRYLKGSLGLGLRICKSDSTLVSAFSDADWAGCPDDRKSTGGFAVFLGANLISWNAWKQATVSRSSTEAEYKALANATAEIISVQTLLKERGIAQPRAACLWCDNIGATSLSANPVFHARTKHIEVDYHFVRERVSQGLLDIRFVPSGDQVADGFTCNRPRRQYIQGGLHCGG
Protein: WD repeat-containing protein 5B (Q4V8C4)
Organism: Rattus norvegicus (Rat)
Function: May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.
Interaction partners:
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Retinoblastoma-binding protein 5
- 5'-AMP-activated protein kinase subunit gamma-1
- Histone-lysine N-methyltransferase
- WD repeat-containing protein 5
- Menin
- Protein dpy-30 homolog
- CXXC-type zinc finger protein 1
- Host cell factor 1
- [histone H3]-lysine
Sequence:
MATEHLPAERAQSPLSAPQRVEEPQKPNYALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIFASFSVTGRKWVVSGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTENIIASAALENDKTIKIWSSDY
Protein: Protein wos2 (p21) (Q11118)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Cell cycle regulatory protein that interacts with cdc2 in the control of the M-G1 transition.
Interaction partners:
- Heat shock protein 90 homolog
- 40 kDa peptidyl-prolyl cis-trans isomerase
- Heat shock protein sti1 homolog
- Uncharacterized protein C1711.08
- Serine/threonine-protein phosphatase T
- NAD reductase coq12
- Tuberous sclerosis 1 protein homolog
- Cell division cycle protein 48
- Histone deacetylase clr3
- Hsp90 co-chaperone Cdc37
Sequence:
MSLNTQIPEVLWAQRSNKDDAEKNVIYLTVLIPDAVDPKINLTPEKLVIDSKSGANAHYAVQIDFFKDIDVEKSKYSVTGRYIFFVLYKKELQEEFWPRLTKEKLRLHWLRTDFDRWVDEDEQEAQPEVSPFGAGGMPDLSALGGMGGMDFSQFGNLGGAGAGEDASDSEPELEEEEEVGSNEKKE
Protein: Myosin IEa (Unconventional myosin-Ie isoform X1) (E7FDV0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGSRGHYRYHWQSHNVKQSGVDDMVLLSKINEDAIVENLKKRYMDDYIFTYIGPVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMMIDRENQCVIISGESGAGKTVAAKYIMGYISKVSGGGPRVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSSGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASGDQKSSLGITSLDYYTYLNQSGSYKVDDINDKHDFQETLHAMDVIGISGIDRTMVLQIVAGILHLGNINFREAGNYAAVENDEFLAFPAFLLGIDQERLKEKLTSRKMDGKWGGKSESIDVTLNVEQACFTRDALSKALHSRVFDYLVESINKAMVKEHQELNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQDEYVQEGIRWTQIEYFNNKIVCDLIESKINPPGIMSILDDVCATMHAKGEGADQTMLQKLRMQINNHEHFNSWNQGFIIHHYAGKVSYDAEGFCERNRDVLFTDLIELMQSSEIAFIRALFPENLNAEKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFRKFLNRYAILTKESWPTWRGDEKQGVLHLLRSVNMDQDQYQLGHTKIFIKAPESLFLLEETRERKFDGYARTIQTAWRKYCARKKYVQMREEASDLLLNKKERRRHSLNRNFVGDYLGMDDRPELRQFMGKREKIDFADKVNKFDRRFKSIKRDLILTPKSVYLIGREKVKQGPEKGLVKEVLKRKIDVEKILAVSLSTLQDDFMILHEDEYDSLLECVFKTEFISLLARRYEERTQRKLPLKYSNTMEMKLKKEKWGPWNAGGSRQVQFMQGQGDVAVLRPSNKMLQVSIGPGLPKNSRPTKKGITQSQPNRSRTHHHTPTRAAPGPPVAHQNGGLKNANHRNSQHHNNQRPTSENTARPFLPTNVSQLKERGSRHAPQQPNLDFLRVPDQGAAGRNRQPTDNGGMAHRQSTNRPAPGGGRPKPAPKPKPQVPQCKALYAYDAQDTDELSFNADDIIEIIKEDASGWWTGRLRGKQGLFPNNYVTKI
Protein: RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (Fox-1 homolog Fxh) (Hexaribonucleotide-binding protein 2) (RNA-binding motif protein 9) (RNA-binding protein 9) (Q8BP71)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity).
Subcellular location: Nucleus. Cytoplasm.
Interaction partners:
- KH domain-containing RNA-binding protein QKI
- RNA-binding protein 24
- Heterogeneous nuclear ribonucleoprotein H
- Heterogeneous nuclear ribonucleoprotein H2
- Muscleblind-like protein 1
- RNA-binding protein Nova-1
- Ataxin-1
- U1 small nuclear ribonucleoprotein C
- Polypyrimidine tract-binding protein 1
- CUGBP Elav-like family member 1
Sequence:
MAEGGQAQQQPPQLGPGAAARGMKRESEVELPVPGAGADGPEPGLSKRPRTEEAADGGMQNEPLTPGYHGFPARDGQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQPHGEQSSNSPSNQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNEAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY
Protein: Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) (A2BGT0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q70CQ3}.
Interaction partners:
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-C
- Polyubiquitin-B
- Si:ch211-202a12.4.
- Ubiquitin-ribosomal protein eL40 fusion protein
- DUSP domain-containing protein.
- Transcription and mRNA export factor ENY2
- Peroxisomal biogenesis factor 5.
- Ubiquitin-specific peptidase 19.
- Ubiquitin-specific peptidase 8
Sequence:
MPWCKQGTTDKLVREFLRTGAAARNKMMKNWGVIGGIAAAMAAGVYVLWGPISDRRKKRKGMVPGLLNLGNTCFMNSLLQGLAACPSFIRWLEDFTSQNSADRERTERETQLSRSLMQLLKALSSHDPGEDDVLDAGGLLEALRLYRWHISSFEEQDAHELFHVLTSSLEEEQERQPRVAHLFDMQTLEKSVESKEKNISCRSGGPLHPIPSLWRTRHPFHGRLTSYMACKRCEQQSPVHYDSFDSLSLSIPSIQWGRPVTLDQCLQHFISSETIKEVECENCTKQQAGELVNGEVLESQRTTFVKQLKLGKRLTWSKEGSPIKRQEHVQFTEYLSLDRYKHCSAAQSQQKTSRTNKAKASADPKDKAIANGVDSEHCNNNKPQSNGTFPSVFLHSPGLSSQLNLTYDYSTSEYLFRLTAVLVHHGDMHSGHFITYRRCPAAPRGTSPFSSQWLWVSDDSVRKASLQEVLSSSAYLLFYERMQRPGLRVEE
Protein: Protein-serine/threonine kinase (EC 2.7.11.-) (O82423)
Organism: Zea mays (Maize)
Subcellular location: Mitochondrion matrix {ECO:0000256|RuleBase:RU366032}.
Interaction partners:
Sequence:
MASEPVARAVAEEVARWGAMRQTGVSLRYMMEFGARPTERTLLLAAQFLHKELPIRIARRALDLDSLPFGLSTKPAILKVKDWYVESFREIRSFPEVRNQKDELAFTQMIKMIRVRHTNVVPAIALGVQQLKKDLGGPKAFPPGIHEIHQFLDRFYMSRIGIRMLIGQHVALHDPDPEPGVIGLINTKMSPMTVARIASEDARAICMREYGSSPDVDIYGDPGFTFPYVTPHLHLMIFELVKNSLRAVQERYMDSDKLAPPVRIIVADGAEDVTIKISDEGGGIPRSGLSRIFTYLYSTAENPPDLDGHNEGVTMAGYGYGIPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLGDSEEPLP
Protein: Nucleolar protein 19 (P53317)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Ribosome biogenesis factor required for cleavage of pre-rRNA at A0, A1 and A2 sites. Essential for the incorporation of UTP25 in pre-ribosomes.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:21941128}.
Interaction partners:
- Protein SQS1
- Casein kinase II subunit alpha
- U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 13
- Casein kinase II subunit alpha'
- rRNA biogenesis protein RRP36
- Casein kinase II subunit beta
- U3 small nucleolar RNA-associated protein 22
- Probable ATP-dependent RNA helicase DHR2
- Something about silencing protein 10
Sequence:
MSRAKELQEKLNLQAKLQSTFSNNTAAVLDWLKESDETGISNDTERNKQLKDHKELEDGKKAFFKLPVLQIGSGLHFRTQDDASAKEDIHTIGEFIEGDKKVSSLAKKKKRSDPGLQRNNMYRITKDDTKAMIALKRKMRKGEKEGLRKKQEHSKSSVSNSYSASDEEDEDAGTMPQKSTKKKFGLLFDKKKKARK
Protein: Mannitol operon repressor (Mannitol repressor protein) (P0AF10)
Organism: Escherichia coli (strain K12)
Function: Involved in the repression of the expression of the mannitol mtlADR operon. Does not bind the operator/promoter regulatory region of this operon. Therefore, seems to belong to a new class of transcription factors in bacteria that may regulate gene expression indirectly, perhaps as a part of a larger transcriptional complex.
Interaction partners:
- Mannitol-1-phosphate 5-dehydrogenase
- Phosphocarrier protein HPr
- PTS system mannitol-specific EIICBA component
- Uncharacterized protein YibL
Sequence:
MVDQAQDTLRPNNRLSDMQATMEQTQAFENRVLERLNAGKTVRSFLITAVELLTEAVNLLVLQVFRKDDYAVKYAVEPLLDGDGPLGDLSVRLKLIYGLGVINRQEYEDAELLMALREELNHDGNEYAFTDDEILGPFGELHCVAALPPPPQFEPADSSLYAMQIQRYQQAVRSTMVLSLTELISKISLKKAFQK
Protein: 26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5) (Q7KMP8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 2
- 26S proteasome non-ATPase regulatory subunit 11
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome regulatory subunit 6B
- 26S proteasome non-ATPase regulatory subunit 6
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome regulatory subunit 4
- GH11341p
- 26S proteasome non-ATPase regulatory subunit 1
- Proteasomal ubiquitin receptor ADRM1 homolog
Sequence:
MSNPQPNVTAYLATQKKTTNKELAAEWTLIEELYNEKLWNELTIKLVTFVRHESLQDETALLQLYQNFLSTFETKINPYGLIQILEVVVDNIGDKKEAIEFLEKMKDKVKICDEAVWYLQVMQGNLYLSNLNDLNATKKIIEELRDVLEEAGNVTPVHGKYYMLASQYYRRVGKHSDYYRCGLQFLGCSMDEYPRDQWAQQAFFLGLAALLGDGVYNIGELLAHPILESLKGTENEWLMELLKAFNTGDINKFNDMKKIWSKIPDLAAQEVKLRQKISLLCLMEMTFKRSAIERAISFTDIAQETKLPAKEVELLIMKALALDLVRGEIDQVAGVVNMSWVQPRVLNRSQIVGMASTLDTWMGAITNMEKLMENRAAEILTN
Protein: Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH) (Q9HBB8)
Organism: Homo sapiens (Human)
Function: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}. Cell projection, microvillus membrane {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:32209652}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}.
Interaction partners:
- Cadherin-related family member 2
- Harmonin
- Cadherin-23
- Unconventional myosin-VIIb
- Cadherin-17
- Ankyrin repeat and SAM domain-containing protein 4B
- Catenin beta-1
Sequence:
MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTDVPPSPEAGGTTGPWTSTTSEVPRPPEPSQGPSTTSSGGGTGPHPPSGTTLRPPTSSTPGGPPGAENSTSHQPATPGGDTAQTPKPGTSQPMPPGVGTSTSHQPATPSGGTAQTPEPGTSQPMPPSMGTSTSHQPATPGGGTAQTPEAGTSQPMPPGMGTSTSHQPTTPGGGTAQTPEPGTSQPMPLSKSTPSSGGGPSEDKRFSVVDMAALGGVLGALLLLALLGLAVLVHKHYGPRLKCCCGKAPEPQPQGFDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGSPTAVRSILTKERRPEGGYKAVWFGEDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGRGGGPYDAPGGDDSYI
Protein: Retinol-binding protein 2 (A0A8A1UAJ7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
HEILGISDPQTLAHVLTVGVQSSLNDPRLFISYEPSTLEAPQQAPALTDLTREELLAQIQRNIRHEVLEDNVGYLRVDDLPGQEVLSELGEFLVSHVWKQLTSTSSLVLDLRHCAG
Protein: Uncharacterized protein (Q57WK9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYFEEEENNDDYNKAEGDESPRSRASSNVSDMPMPPLPPPTPPADVYGLATEEIYSIIKELRRQIDDPTTHHDIKAMLKKEPSILLAVTRVLHESGLLRRGVVNAHGQVEEQIVPLPEAPAPPLPTGYSSWV
Protein: Protein transport protein sec9 (O74786)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in cell separation, a final step of cytokinesis and in the assembly of the forespore membrane. May have a role in the transport of secretory proteins to these growing sites.
Interaction partners:
- Syntaxin-like protein psy1
- Synaptobrevin homolog 1
- Probable vesicular-fusion protein sec17 homolog
- Protein transport protein sec22
- Exocyst complex component sec6
- Protein transport protein sec1
- Uncharacterized protein C1F3.03
- Syntaxin pep12
- Integral membrane protein sed5
- Vesicular-fusion protein sec18
Sequence:
MKKLFKKKKGVSPHMYMLPEESNSNTATNAPSYSVGGTTANSYSSNSYNDNNNSNSTYGSSNNYGNYGSSNNYGSYGASNTYGSNGSSNNYGNYGATNSNGDAGYSITPIRNDPYARKDMPPMKSSAAVTERPSMHRSAPSQDTLDLKKQELFAGARIQNDDESTTDTIPHNDDGTEGDEYGEGYRDGYEEDQEVEAIKQKIQFVKQDSLSSTRNALLMAGNAEQMGLATLANLGEQTEKIATAEKELDISKIHAKRAEEQARELKTLNRSMFAIHVPKPWGKAKRVAAEEARLAAKRDAERQDEMLNRQFAYRSQKRIDQAMKDNMKSNKKKGDSKGVSILERSHYQFEPDAEDDAMEKEIDGNLDQIGALATRLKGLAYATGQEIDSQNARLGSIHDKSDRLDTDVYLNVERLRHIH