wanglab/gogpt-training-data huggingface dataset:
Protein: Nucleoside diphosphate kinase homolog 7 (NDK 7) (NDP kinase homolog 7) (3'-5' exonuclease NME7) (EC 3.1.-.-) (Protein kinase NME7) (EC 2.7.-.-) (nm23-H7) (Q9Y5B8)
Organism: Homo sapiens (Human)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24807905, ECO:0000269|PubMed:38538594}. Nucleus {ECO:0000269|PubMed:24807905}. Cytoplasm {ECO:0000269|PubMed:24807905}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:24807905}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189, ECO:0000269|PubMed:37258679}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q5E9Y9}. Cell projection, cilium {ECO:0000269|PubMed:38538594}. Note=Localizes to centrosomes through its assembly into gamma-tubulin ring complex. The centrosomal content of NME7 varies during the cell cycle, being highest in mitosis and lowest in early G1. {ECO:0000269|PubMed:24807905}.
Interaction partners:
- Mitotic-spindle organizing protein 1
- Gamma-tubulin complex component 5
- Gamma-tubulin complex component 4
- Protein NEDD1
- Mitotic spindle organizing protein 2B
- Inosine triphosphate pyrophosphatase
- Adenylate kinase 9
- Cancer-related nucleoside-triphosphatase
- Guanosine-3',5'-bis
- Thymidylate kinase
Sequence:
MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFKILDN
Protein: Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin) (Q86XR8)
Organism: Homo sapiens (Human)
Function: Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.
Interaction partners:
- Centrosomal protein of 63 kDa
- Serine/threonine-protein kinase PLK1
- Centrosomal protein of 152 kDa
Sequence:
MAAASVSAASGSHLSNSFAEPSRSNGSMVRHSSSPYVVYPSDKPFLNSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSLCWDY
Protein: Alpha v integrin subunit variant (Integrin alpha V) (Integrin alpha-V isoform 1 preproprotein) (A2RQD8)
Organism: Sus scrofa (Pig)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Interaction partners:
Sequence:
MASLPRRRLRLRPRRLLLLLPGFLLPLCGAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSMFLLVGAPKANTTQPGIVEGGQVLKCDWSSHRGCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSKNIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPKVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLHNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQKASGNFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRPTGLNAVPSQILEGKWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAVLYRARPVITVNAGLEVYPSILNQDNKTCPLPGTDLKVSCFHVRFCLKADGKGTLPTKLNFQVELLLDKLKQKGAIRRALFLHNRFPGHSKNMTISRGGQMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYTTAADVTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYVGDDNPLTLIVKAQNQGEGAYEAELIVSIPPQADFIGVVRNSEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVQQQSEMDTSVKFDLQIQSSNLFDKVSPVVSYKVDLAVLAAVEIRGVSSPDHIFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLNLQWPYKYNNNTLLYILQYDIDGPMNCTSDMEINPLRIKISNSQTEKNDTVGGQGDRNHLVTKRDLTLIEGDVHTLGCGIAECLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDIFNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET
Protein: Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) (P17655)
Organism: Homo sapiens (Human)
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).
Subcellular location: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.
Interaction partners:
- Calpain small subunit 1
- Calpastatin
- Calpain-1 catalytic subunit
- Talin-1
- Talin-2
- BH3-interacting domain death agonist
- Cellular tumor antigen p53
- Bcl-2 homologous antagonist/killer
- Cyclin-dependent kinase 5 activator 1
- Apoptosis regulator BAX
Sequence:
MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL
Protein: Transport permease protein (Q9HTB8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|RuleBase:RU361157}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361157}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- ABC subunit of A-band LPS efflux transporter
- Probable ATP-binding component of ABC transporter
- Alginate biosynthesis protein AlgA
- Glycosyltransferase WbpX
- D-rhamnosyltransferase WbpZ
- Glycosyltransferase WbpY
- GDP-6-deoxy-D-mannose reductase
- GDP-mannose 4,6-dehydratase
- Transport permease protein
- O-antigen translocase
Sequence:
MLLGLSRSLWGYRGFVLGSVKREFQSRYRGSLFGALWTVLNPLSMIVVYTVIFSQVMRARLPGVDDGLAYSVYLCAGLLTWGLFAEITSRSQSMFIENANLLKKISFPRICLPVIVLLNAGVNFAIILALFLGFLALSGRLPGAALLALVPLLAIQVLFAAGLGMILGVLNVFFRDVGQLFGICLQFWFWLTPIVYPIGILPEGIRSLIELNPMTALMRSYQQLFLHGQWPDWPSLLPITLLALLLCALGLRLFRQRVGEMVDEL
Protein: RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (RdRp) (Replicase) (Transcriptase) [Includes: cap-snatching endonuclease (EC 3.1.-.-)] (P23456)
Organism: Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Function: RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate (By similarity). During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. Cleaves ssRNA substrates but not DNA (By similarity). Seems to downregulate the expression of its own and heterologous mRNAs through its endonuclease activity (By similarity).
Subcellular location: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q9YQR5}.
Interaction partners:
Sequence:
MDKYREIHNKLKEFSPGTLTAVECIDYLDRLYAVRHDIVDQMIKHDWSDNKDSEEAIGKVLLFAGVPSNIITALEKKIIPNHPTGKSLKAFFKMTPDNYKISGTTIEFVEVTVTADVDKGIREKKLKYEAGLTYIEQELHKFFLKGEIPQPYKITFNVVAVRTDGSNITTQWPSRRNDGVVQYMRLVQAEISYVREHLIKTEERAALEAMFNLKFNISTHKSQPYYIPDYKGMEPIGANIEDLVDYSKDWLSRARNFSFFEVKGTAVFECFNSNEANHCQRYPMSRKPRNFLLIQCSLITSYKPATTLSDQIDSRRACSYILNLIPDTPASYLIHDMAYRYINLTREDMINYYAPRIQFKQTQNVREPGTFKLTSSMLRAESKAMLDLLNNHKSGEKHGAQIESLNIASHIVQSESVSLITKILSDLELNITEPSTQEYSTTKHTYVDTVLDKFFQNETQKYLIDVLKKTTAWHIGHLIRDITESLIAHSGLKRSKYWSLHSYNNGNVILFILPSKSLEVAGSFIRFITVFRIGPGLVDKDNLDTILIDGDSQWGVSKVMSIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQYAIRSVFANHFLLAICQKMKLCAIFDNLRYLIPAVTSLYSGFPSLIEKLFERPFKSSLEVYIYYNIKSLLVALAQNNKARFYSKVKLLGLTVDQSTVGASGVYPSFMSRIVYKHYRSLISEVTTCFFLFEKGLHGNMNEEAKIHLETVEWALKFREKEEKYGESLVENGYMMWELRANAELAEQQLYCQDAIELAAIELNKVLATKSSVVANSILSKNWEEPYFSQTRNISLKGMSGQVQEDGHLSSSVTIIEAIRYLSNSRHNPSLLKLYEETREQKAMARIVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAIAKNISEEYISYGGEKKILAIQGALEKALRWASGESFIELSNHKFIRMKRKLMYVSADATKWSPGDNSAKFRRFTSMLHNGLPNNKLKNCVIDALKQVYKTDFFMSRKLRNYIDSMESLDPHIKQFLDFFPDGHHGEVKGNWLQGNLNKCSSLFGVAMSLLFKQVWTNLFPELDCFFEFAHHSDDALFIYGYLEPVDDGTDWFLFVSQQIQAGHLHWFSVNTEMWKSMFNLHEHILLLGSIKISPKKTTVSPTNAEFLSTFFEGCAVSIPFVKILLGSLSDLPGLGYFDDLAAAQSRCVKALDLGASPQVAQLAVALCTSKVERLYGTAPGMVNHPAAYLQVKHTDTPIPLGGNGAMSIMELATAGIGMSDKNLLKRALLGYSHKRQKSMLYILGLFKFLMKLSDETFQHERLGQFSFIGKVQWKIFTPKSEFEFADMYTSKFLELWSSQHVTYDYIIPKGRDNLLIYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCRLDGEWVTFREVLAAANSFAENYSATSQDMDLFQTLTSCTFSKEYAWKDFLNGIHCDVIPTKQVQRAKVARTFTVREKDQIIQNSIPAVIGYKFAVTVEEMSDVLDTAKFPDSLSVDLKTMKDGVYRELGLDISLPDVMKRIAPMLYKSSKSRVVIVQGNVEGTAEAICRYWLKSMSLVKTIRVKPHKEVLQAVSIFNRKEDIGQQKDLAALKLCIEVWRWCKANSAPYRDWFQALWFEDKTFSEWLDRFCRVGVPPIDPEIQCAALMIADIKGDYSVLQLQANRRAYSGKQYDAYCVQTYNEVTKLYEGDLRVTFNFGLDCARLEIFWDKKAYILETSITQKHVLKIMMDEVSKELIKCGMRFNTEQVQGVRHMVLFKTESGFEWGKPNIPCIVYKNCVLRTSLRTTQAINHKFMITIKDDGLRAIAQHDEDSPRFLLAHAFHTIRDIRYQAVDAVSNVWFIHKGVKLYLNPIISSGLLENFMKNLPAAIPPAAYSLIMNRAKISVDLFMFNDLLKLINPRNTLDLSGLETTGDEFSTVSSMSSRLWSEEMSLVDDDEELDDEFTIDLQDVDFENIDIEADIEHFLQDESSYTGDLLISTEETESKKMRGIVKILEPVRLIKSWVSRGLSIEKVYSPVNIILMSRYISKTFNLSTKQVSLLDPYDLTELESIVRGWGECVIDQFESLDREAQNMVVNKGICPEDVIPDSLFSFRHTMVLLRRLFPQDSISSFY
Protein: Copia-like retroelement pol polyprotein (Mitochondrial ATP synthase subunit G protein) (Q9STR3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
- AT4g29480/F17A13_300
- Copia-like retroelement pol polyprotein
Sequence:
MASKLLQLKSKACEASKFVSKHGTTYYKQLLDKNKMYIQEPATIEKCNELSKQLLYTRLASIPGRSESFWKEVNHVKGLWKNRADLKVEDAGIAALFGLECFAWYCAGEIVGRGFTFTGYYP
Protein: Neuralized-like protein 2 (Q9BR09)
Organism: Homo sapiens (Human)
Function: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Spermatogenesis-associated protein 25
Sequence:
MAAASEPVDSGALWGLERPEPPPTRFHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGRPEAEAAAPSRPPTLLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYELNVLPPTARRSRLGVLFCPRPDGTADMHIIINGEDMGPSARGLPAAQPLYAVVDVFASTKSVRLVQLEYGLPSLQTLCRLVIQRSMVHRLAIDGLHLPKELKDFCKYE
Protein: Mitogen-activated protein kinase kinase kinase kinase (EC 2.7.11.1) (Q8SYA1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAAAHSHHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGLPAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLSGDAVVGGNGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQQIGLLENMGKSPRTRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMSLSGKSCQLYRHDLVALHSKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPVFEMIITPELEYPIVCTGVRKAMNGCLKLELINMNSASWFHSEDLEYDAMATMVPRRDLLKVVRVHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY
Protein: tRNA endonuclease vms-1 (EC 3.1.-.-) (P34511)
Organism: Caenorhabditis elegans
Function: Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Component of an evolutionarily conserved system for ubiquitin-mediated mitochondria-associated protein degradation (MAD) (By similarity). Dispensable for viability and growth but is required for protection against oxidative stress and for wild-type life span.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21070972}. Mitochondrion {ECO:0000269|PubMed:21070972}. Note=translocates from the cytosol to mitochondria upon exposure to hydrogen peroxide.
Interaction partners:
- Ubiquitin fusion degradation protein 1 homolog
- Ubiquitin conjugation factor E4 ufd-2
- Ubiquitin fusion degradation protein 3 homolog
- Major sperm protein 32
- Transitional endoplasmic reticulum ATPase homolog 2
- Eukaryotic translation initiation factor 6
- UBX domain-containing protein 6
- Transitional endoplasmic reticulum ATPase homolog 1
- Transmembrane GTPase fzo-1
- Nuclear export mediator factor NEMF
Sequence:
MGFTLKSLEFLQGVEPFRIDENHENEGASEEEEVLISAETDAGMSLMLEWKMRLSEDSDQCTTCNCPVDFGDRAVLLEHYQSLFHRTNTLRKARNMTVYTEEDFEGIENSENDLTSSQTTIGLESDDEEFDALLLPANRSFFIKNGSVFSVPRNILHVGERDVSSVTFLRPFDCAIFLWNGGHFAAAMFENDKMTVQKSFHRYVARAKQGGVQSQHDSGGKGAAKSAGAQLRRYNEQKMKEEIQSIMSSWKSRLQKTPLLFIRCAAYHRNIFFEADAGIETRDDRIRTIPFETKRPNIDEISDCWQRLQQVSEHGAESDFRAEMLEVREKRKKLARKVAGKKRKDGGMQMICEWSDDDENEDISKEKKTHHIKVRTIKKPEETVVQWPRLDDEWRQKTYNYVRQDSVEALKEHLASLNEDVTSEANDYLRNAKIPPNRSTFLHVSAANDARKCLKYFLEEVNCDSSTKDGAGLPPYSSSANSDVKSIFIDYRVKNETAGNWARTHIPEPKKKVELTEEQEREQAERKKEKKARQKEKEKLKKEIAKRDVEEMEERQKYVNMSEREKRALAVDRRLAGLPPILRCHQCGVQLPPTPFQYSHYNFCSTSCVAEHRKANPQ
Protein: No mechanoreceptor potential A, isoform F (A0A0B4LF37)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRPRKGIHVLLTTLVVSLSLSKINGQTTCKNGLGRVLYERLPNQQLQGYDDDVVRDTAPPFRVLEKCQDLCLRDRSGSNNLVRTCTSFDFQPGSRITSFGGNSEYEESLCYLTSEQAGPEGIGSLMLVPNSVHFNEICLTSSRPERECPSRRYVFERHPRKKLKLPISDIKEITAANRSDCEDKCLNEFSFVCRSANFDSTMRSCTLSRFTRRTHPELMEDDPNSDYLENTCLNAERRCDGLAVFVKEENKRLGGPFEVDIFNNMTLEECQTMCLRAEKYFCRSVEFDDQSKQCILSEEDSISQKDDISISSSPTHHFYDLVCLDNQRANDYPDNSVTSHLFSSGRRPDTAFQRYRNSRLGGEFHSEITGRSLSECLDECLRQTSFQCRSAVYSDRFRTCRLSRYNQKDGMRIIYDADYDYYENLMLNVVGGGADGDGGGHGGSSDGKRPGDQSGSNWRQPNKHDDRYGSGGSSVGGGSHGGTGSGGSRLPPGEGVDYGRPYDRYPDIAGNEYDRNPYGGDRDRDRYPPDRYGSRYPTGGDGIGYNRPYDRFPDDYGLERPPPPFYDYDYEERYGDRYGPYDREYDGPPGRRPPSGGPYGRYDSPFNRPYGGNGLDDRPLPLPGLGLSHPPTPYGGGGAGHVGVGVGVNSGPPRPPITRCEESDNFKQIAARHKMRRHFVRRALIVPSLIQCERECIESRDFVCRSFNYRDSAASGYEDRDRDRDRDSPNCELSDRDSRELDIHDPGTFDASNYDFYERSIGRSDGECMDVTQTCNEEGMEFTIRTPEGFLGRIYTYGFYDRCFFRGNGGTVNVLRLSGPQGYPDCGTQRYGDTLTNIVVVQFSDNVQTSRDKRYNLTCIFRGPGEAVVSSGYIGAGSGSPIPIEYLPAENTLSSKVRLSILYQGRPTTTIAVGDPLTFRLEAQDGYNHVTDIFATNVVARDPYSGRSIQLIDRFGCPVDPFVFPELDKLRDGDTLEARFNAFKIPESNFLVFEATVRSCREGCQPAYCPGPAGRQEPSFGRRRRSLNTTEIPEPEALALEGSSQLEASTLDEVTVVNSTTVSATLGQVPLNETQLGEKTKETEEPEQVREMIEVFETREEIEKESYPRKLVAPVETVCMTPAEYHGLITAIILLMILLFSITLVAGLGYRRYWKSISKNRLVDRHSPIHSLGHSHSSIRTHERFTEIGHMPNLNGGGGGAAAGTGGGANQSASNRASNAFRTNMSMFGGSLHKTFATGNLARMCQLPVINPMRSTNQSSHQFEDPSEPIYTDPSLFERSRQVADHSVTHPQNEFPTTVRNYRCEV
Protein: BPTI/Kunitz inhibitor domain-containing protein (Q5ZR35)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLSISDSCDLKFEPVLREECISADWAEKFFWNSEFKDCEPFWYDSSCDPRDRAGKNFFETFEDCKNKCDGVQSQYVVPITTVPDEQSKIEEVETSETPGIVDETTTTAAPEEESEENGFFFKVKPQNYLEDVLSSETEETQHYGFNPNEFLKQNSQNQKPTEITEILRILPAQTEHDEASELKKEDKIEHDILEHLKNKEPTEKVLSTPSTCDLEYDDALRNECTSADWTELYYWNAQFKECEAFWYDSSCGDQDFSKKNLFKNFDDCNNQCVKKIGEALKKMDPETTTTTSTTTTTTTAPTTTKMEEPKRSNYKQSDPLNLILNKALNPDESSELPEKFPPAHEQGFVNFAIKSEVTATTKFDRLKYMAEFRKKLLALPDNFSTTPKQSSPTSSPTTTRMRSPSTHKSTVSQATKTASSTPQSPSTTTSFDDFVEKEKKTVLETIKILDRPEDLCDEPLHPKLEEDCKNDQWEIQWFFNSDRGACKSFWYGGCEIESRNFFPDHANCRHSCAHKYATPASFSSKVYIPPGELSTPVPPRKDRLTTSLKLTYPHSEDLFPSEEHSTVVELDGNFQRTEKQERIRLFPTKTFRPRAPTPTASNIVNVSEGEKTETAPAFYSHIDRVVHDMKTGEHPGYTKPEEFVRRIESASNDYIKYDLQKPDVVTIIDKSPPTVPSRKERTERTEVTTKLPSTRSINDPCDDEYDPKWDEDCLGDTWVVRSYYDSKAEKCKAFWYGGCHTSSRNIWFDKETCRTSCAHKFPTDMPMYGGAQSSEVSAEILPSPQEENSSKETSSSSSSSSSSNTAHISPEHRFKVDLDQKFADVKREHEGREDLAYSQMVQHPVTVSADCLEVYNASLSKPCGDGKSWSNRYFYDKDTRSCRMFWSNGCFSSSKNNFDDLETCQWKCEGRHPQPAGKSCLDKFDERYLEDCRHGEFTNRFYFDHDRKKCVAFHWGGCQSKSQNFFADMTVCQDLCESPPRELTQACLQPFDTTYETSCSAEKPQQYYYFDMSSGICKMFWFGNCKGENQNIFSTLEACQWICERKRDERKPAICADKFDTKYTESCGDSQWTEKWYFDQSSGDCSSFWWDECTSSSQNIFPDEKSCTSNCKHPGFEISSKLATEESKFRCLEPVEIGSCQETYPAFYYDRASRTCRPFAYSGCGGNSNRFMTVSQCENLCFAFNSMNEAEVDCHLPMHIGYGKNEDSCLPQAGFRFYYDRNYGKCSQMWYLGCGGNANNFYSYEICQRTCSQSDVPRELERKTRASSEVCFEPPGDRGICGKNSSTNPLKRWTYGNQKCTSFTYSGCGGNRNRFATQDICENTCNGLMNSNDPRICSFSPDWGSCNQLRYVWFYNLTRGTCDQFLYGGCGGNPNRFDTFEICQKACEVTGTDPCMESLDRGSWCEAMSNRYYFNKRARQCKGFHYTGCGKSGNNFLTKEECQTKCEKRFPRAAPSKKKAKVKLPVGYSGAKPKDKTPMLRHINLNGNNQTYFKSEPQWMDYSSCYGYRYNVTGRDTILNVHYCAIRGSADCISESYRSTEGEEYCNILRPFLRGQNLYSFYFGLDSVNPMYRPKDGLSGRIQRKNETIAAVLVLKANQCHEIC
Protein: Spondin-2 (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1) (Mindin) (Q9BUD6)
Organism: Homo sapiens (Human)
Function: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Targeting protein for Xklp2
Sequence:
MENPSPAAALGKALCALLLATLGAAGQPLGGESICSARALAKYSITFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNQYVSNGLRDFAERGEAWALMKEIEAAGEALQSVHAVFSAPAVPSGTGQTSAELEVQRRHSLVSFVVRIVPSPDWFVGVDSLDLCDGDRWREQAALDLYPYDAGTDSGFTFSSPNFATIPQDTVTEITSSSPSHPANSFYYPRLKALPPIARVTLVRLRQSPRAFIPPAPVLPSRDNEIVDSASVPETPLDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAECVPDNCV
Protein: Sorting nexin-33 (SH3 and PX domain-containing protein 3) (Q8WV41)
Organism: Homo sapiens (Human)
Function: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.
Subcellular location: Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941). {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:21048941}.
Interaction partners:
- Sorting nexin-9
- Sorting nexin-18
- Dynamin-1
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
Sequence:
MALKGRALYDFHSENKEEISIQQDEDLVIFSETSLDGWLQGQNSRGETGLFPASYVEIVRSGISTNHADYSSSPAGSPGAQVSLYNSPSVASPARSGGGSGFLSNQGSFEEDDDDDWDDWDDGCTVVEEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGSVVGRNLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSVEDPTKQTKFKGIKSYISYKLTPTHAASPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDTFKAFSKKMDDSVLQLSTVASELVRKHVGGFRKEFQKLGSAFQAISHSFQMDPPFCSEALNSAISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRMVQDEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQNYLRQQILFYQRVGQQLEKTLRMYDNL
Protein: Elongator complex protein 4 (AtELP4) (Elongator component 4) (Protein ELONGATA 1) (Q9C778)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Promotes organ development by modulating cell division rate. May regulate mechanisms producing carbon assimilates or importing sucrose. Involved in the repression of the abscisic acid (ABA) signaling pathway during seed germination and seedling growth. Required for auxin distribution or signaling. Involved in oxidative stress signaling. Prevents anthocyanin accumulation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96EB1}. Nucleus {ECO:0000250|UniProtKB:Q96EB1}.
Interaction partners:
- Elongator complex protein 1
- Elongator complex protein 3
- Elongator complex protein 2
- Elongator complex protein 6
- Protein KTI12 homolog
- Elongator complex protein 5
- Radical S-adenosyl methionine domain-containing protein 1, mitochondrial
- Vacuolar-sorting receptor 1
- F25A4.4
Sequence:
MAAPNVRSSSSFSRNISVVSSPQIPGLKSGPNGTAFISSGIRDLDRILGGGYPLGSLVMVMEDPEAPHHMDLLRTYMSQGLVNNQPLLYASPSKDPKGFLGTLPHPASSKEDKPTAPDPDQGESLRIAWQYRKYLENQKNAIDDYSNDFDMRKPLERQFLSGRPIDCVSLLDSSDLSIAQDHCATFLSKFPRNSSNIASIGRIAIQSFCSPLCEYSEKESDMLSFIRLLKSMLMVSNAVAIVTFPPSLLSPSSSKRLQHMADTLLSIKAIPDGDKELEKLLTGYKDINGFLNIHKVARINTQVPVILEAKTFSMSLKKRRFLALECLNQAPVDGSSGTSYGTSGSCSSKSGALDF
Protein: SMG7 nonsense mediated mRNA decay factor (B1ALB4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPLQNESQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPHEEDLSSISATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQETSVIESLAADGSPGLKSVLSTSRNLSNNCDTGEKPVVTFKENIKTREVNRDQGRSFPPKEVKSQTELRKTPVSEARKTPVTQTPTQASNSQFIPIHHPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQPTAHSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGPQQSQPPSQQPLTSLPAQPTAQSTSQLQVQALTQQQQSPTKAVPALGKSPPHHSGFQQYQQADASKQLWNPPQVQGPLGKIMPVKQPYYLQTQDPIKLFEPSLQPPVMQQQP