wanglab/gogpt-training-data huggingface dataset:
Protein: Toxin Css39.8 (B7FDP2)
Organism: Centruroides suffusus (Durango bark scorpion)
Function: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is lethal to crustaceans (freshwater crayfish (Cambarellus montezumae spp.)), it provokes a reversible paralysis to insects (crickets (Achaeta spp.)), but is not toxic to mice. At high concentrations, it does displace the (beta) mammal-specific toxin Cn2 from rat brain synaptosomes.
Subcellular location: Secreted {ECO:0000269|PubMed:19631296}.
Interaction partners:
Sequence:
MNSLLMITACFFLIGTVWAKEGYLVNKSTGCKYGCLLLGKNEGCDKECKAKNQGGSYGYCYAFGCWCEGLPESTPTYPLPNKSCSKK
Protein: b(0,+)-type amino acid transporter 1 (b(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9) (P82252)
Organism: Rattus norvegicus (Rat)
Function: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney proximal tubule.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:10506124, ECO:0000269|PubMed:16358225}; Multi-pass membrane protein {ECO:0000305|PubMed:10506124, ECO:0000305|PubMed:16358225}.
Interaction partners:
- Amino acid transporter heavy chain SLC3A1
- Solute carrier family 7, member 15
- Amino acid transporter heavy chain SLC3A2
- Sodium-dependent neutral amino acid transporter B
- Transporter
- Neutral amino acid transporter B
- Amino acid transporter
Sequence:
MEETSPRRRREDEKSVHSTEPKTTSLQKEVGLLSGICIIVGTIIGSGIFISPKSVLANTESVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYLGCRPPAVVVKLLAAAAILLITTVNALSVRLGSYVQNVFTAAKLVIVAIIIISGLVLLAQGNVKNFQNSFEGSQTSVGSISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFTVMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVKRLTPAPALVFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILGLVVMRFTRKDLERPIKVPIFIPIIVILVSVFLILAPIISSPAWEYLYCVLFILSGLIFYFLFVHYKFRWAQKISRPITKHLQMLMEVVPPEKDPE
Protein: Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) (O70536)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrateb a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P35610}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35610}.
Interaction partners:
- Delta
- 7-dehydrocholesterol reductase
- Sterol O-acyltransferase 2
- Cholesterol 24-hydroxylase
- Cholesterol 25-hydroxylase
- Cytochrome P450 7A1
- Sterol 26-hydroxylase, mitochondrial
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Steryl-sulfatase
- Neutral cholesterol ester hydrolase 1
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
Protein: DDT domain-containing protein (F4KB54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00475}.
Interaction partners:
- DNA polymerase II subunit B4
- DDT domain-containing protein DDR4
- PHD finger family protein
- DDT domain-containing protein PTM
- WD-40 repeat-containing protein MSI3
- PHD-finger and DNA binding domain-containing protein
- Uncharacterized protein At5g25580
- Zinc-finger domain of monoamine-oxidase A repressor R1 protein
- Homeobox-DDT domain protein RLT1
- Homeobox-DDT domain protein RLT2
Sequence:
MPLLKKKSHKLLEPPKNLEPQELVYQVRLTNEIFRDYQLYLKRLNLYRNRVWTCKSTGKTSLSYEEALDSEKLAGKKVQTLPRELVAPALRIIQFSTLSLKDLADKIATELQDCFFPGAELYGERDGELHPCKILRIVSDGDSKPQYEVGFLDKNKEVDDNTVLFGEDLSWKKFPFSRNFLKSFIRDSTCHSIPWVVNDYLAKAHEITRKIPKELQNKYVFQNGELVQQRKQEDKTGRENRKRKRAENGKHVAEETDREVNGSEEEAINYPIEDLLLPPDPDVTQRPSPSRDFSVPMDCVGDLLMVWDFCTSFGRQLHLWRFSLEDFENAVCHKESNLVLIMEVHASLFRFLINERGDSFKALQRRSRKSKITLITWAEYLCDFLESVNTPDLCFDVGTIKRGHYGLLDPNVKLKILRELVNHITETGMFKGEIDELVEQRHALGAARREEALAEARQIREEKERSKTGEEANGVLDNNRLEKKKNSAQVLESSEDSKKNESTAGGSKMENGSVSSENIEKSEKRLIGNVYLRKHKRQMTDTKIEPKEEEEDEKAEEDEEEKGFSVKKQEVKSASEDEKGTFERRGPEQRRQYYEREMEKIVIRTNPLGKDRDYNRYWWFRSNGRIFVENSDSEEWGYYTAKEELDALMGSLNRKGERELSLYTQLEIFYDRICSTLQKRTKDIAHNIEMEEAVVRRSTRVRAPLHENPASAFLRYVNKWKED
Protein: Chromosome 3, complete genome (A0A0E0SJI5)
Organism: Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)
Interaction partners:
Sequence:
MKFSIAALSLVTLAAASPVQERTNYISYEGLKRDGTPCSLVTVSWQNCRPAAYANTWSRGCSPITRCRDGYPPGP
Protein: Ethylene-responsive transcription factor 14 (AtERF14) (Ethylene-responsive element-binding factor 14) (EREBP-14) (P93822)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Basic endochitinase B
- CBL-interacting Serine/Threonine-kinase
- Defensin-like protein 16
Sequence:
MDQGGRSSGSGGGGAEQGKYRGVRRRPWGKYAAEIRDSRKHGERVWLGTFDTAEDAARAYDRAAYSMRGKAAILNFPHEYNMGTGSSSTAANSSSSSQQVFEFEYLDDSVLDELLEYGENYNKTHNINMGKRQ
Protein: EF-hand domain-containing family member B (Cilia- and flagella-associated protein 21) (F1MMV1)
Organism: Bos taurus (Bovine)
Function: Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37327785}. Cytoplasm {ECO:0000250|UniProtKB:Q8N7U6}.
Interaction partners:
- WD_REPEATS_REGION domain-containing protein.
- Cilia- and flagella-associated protein 107
- Tektin-3
- Meiosis-specific nuclear structural protein 1
- Tektin-1
- Tektin-4
- RIB43A-like with coiled-coils protein 2
- Tektin-2
- Protein Flattop
- Cilia- and flagella-associated protein 52
Sequence:
MCSFLRVPSPKGLEPSKGLGAPLQPGTAYPSEMSALGPGMTVSGRKSPLSMEVGLAPEGKDDLEERRVFMGTTSPTELGLRVGLRKDFPCSKTYEERMASPEIRSPSSKGLELRLKRQNISRTVMDGSNLGVHRVSASQETKPPLSALPGRVGLEKERFLAGYCPGRVTQPPLGQGCESPQASGGRRCPVTGDPEGFGASVSKLPALGMECRGELGGESACVVMKPRAETEPPVEVDMGLTRLEEPAEMESPEPQMGLVMEPPAWQLAQQPEEQREAENTEPGVEPPDRIRPIYSGKFFDRMPCWPSAGKVLPIGYRAATCLTERFPRLMTPPEAKKFFNFRYPPAGAERVFYGRANDPQIAPSLTHGIRSKISIPAKVLINPQPITTFQQKMKDKKESVYFSNQRAPLGKSHDQTPGLPKGLDILNTTFGTAIVRETSARDMVNPPKPYKEVFEEAQAGHDLYVVSHNDYFVGEAKNRKYDPSSFHRFNLYGIPTPHFNDGRNMAKTLHWLHELQMKRGAKIVSKRVDDFKEKFQHRLGRVLDPIAETMNVPPDYTFGAFLRPEDYGVGDLIHRRLPGEYLRGKDRQRGLVAAVRHHLKKVNYQNFDTLLAAFRHYDKKGDGVIDRAELQEACDQACLHLDEKLLDQLFEYCDVDKDGLINYLEFANFLTWKDKTPLKEYEERVLIKGRKADCANPAEANVEESEPALLLKPEDIVLKEPGSSEKTLRTLLRPSDKVSNHYKTTSSEISAVVGAVPSTCYPTYGVPTIRSDIPAPLIRRVSDRTSYGEEGNAYSLLHPTIFAQKGVFERDFFKTRSKQEISEILCNIGVKLSEDEFENVWNLASKKHHRGEVCVENIRSVLDELQHADGAKCKAAT
Protein: Harvey rat sarcoma viral oncoprotein isoform A (X5D945)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
Protein: RNA silencing suppressor (21 kDa protein) (p21) (Q08545)
Organism: Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus)
Function: Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to ssRNAs and dsRNAs in vitro. Also functions as replication enhancer.
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:12642093}.
Interaction partners:
Sequence:
MKFFLKDGETSRALSRSESLLRRVKELGTNSQQSEISECVDEFNELASFNHLLVTVEHREWMEQHPNQSSKLRVPSRIGEMLKEIRAFLKVRVVTPMHKETASDTLNAFLEEYCRITGLAREDALREKMRKVKSVVLFHHSELLKFEVTENMFSYTELLKLNLSLRVISSQILGMAI
Protein: UDP-glycosyltransferase 73C11 (EC 2.4.1.368) (Oleanolate 3-O-glucosyltransferase UGT73C11) (K4GGT4)
Organism: Barbarea vulgaris (Yellow rocket) (Erysimum barbarea)
Function: Catalyzes the transfer of a glucose (Glc) moiety from UDP-Glc to the C-3 position of the oleanane sapogenins oleanolate and hederagenin, and to the C-28 carboxylic group of the lupane sapogenin betulinate. The monoglucosylated hederagenin 3-O-beta-D-glucoside is a feeding deterrent of the yellow-striped flea beetle (Phyllotreta nemorum).
Interaction partners:
Sequence:
MVSEITHKSYPLHFVLFPFMAQGHMIPMVDIARLLAQRGVKITIVTTPHNAARFENVLSRAIESGLPISIVQVKLPSQEAGLPEGNETFDSLVSMELLVPFFKAVNMLEEPVQKLFEEMSPQPSCIISDFCLPYTSKIAKKFNIPKILFHGMCCFCLLCMHVLRKNREILENLKSDKEHFVVPYFPDRVEFTRPQVPMATYVPGEWHEIKEDIVEADKTSYGVIVNTYQELEPAYANDYKEARSGKAWTIGPVSLCNKVGADKAERGNKADIDQDECLKWLDSKEEGSVLYVCLGSICSLPLSQLKELGLGLEESQRPFIWVVRGWEKNKELLEWFSESGFEERVKDRGLLIKGWSPQMLILAHHSVGGFLTHCGWNSTLEGITSGIPLLTWPLFGDQFCNQKLVVQVLKVGVSAGVEEVTNWGEEEKIGVLVDKEGVKKAVEELMGESDDAKERRKRVKELGQLAQKAVEEGGSSHSNITSLLEDIMQLAQSNN
Protein: Probable indole-3-acetic acid-amido synthetase GH3.9 (EC 6.3.2.-) (Auxin-responsive GH3-like protein 9) (OsGH3-9) (Q6ZLA3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May catalyze the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin.
Interaction partners:
Sequence:
MFVKSETKTRGGLTAWFALTSVYKSEQFKSMAIAYTSPTAAILCEDAFQSMYAQMVCGLCQRHDVVRFGAVFAAALVRAIRFLQLNWGQLAADIEAGELGPHVADPSVREAVSGILRSDAELAEFVRIECSKGDWAGIITRIWPNTKYVDAIVTGAMAQYIRTLQYYSGGLPIVSTSYASSECFFGINLRPVCDPSEVSYTIMPNTAYFEFLPVGEVVDATNLVDLARVEVGREYEVVITTYAGLSRYRVGDVLRVTGFHNAAPQFRFVRRQSVLLSVELDKTDEAELHRAVERASSALLRPRGVSVAEYTSRACTERIPGHYVVYWELLTESPVGAGDGDTVDGETLGRCCLEMEEALSAVYRQGRVADGSIGPLEIRIVRPGTFEEVMDLAVSRGTSIGQYKVPQCVTVPSVVELLDSRVVSSQFSPALPHWIPTPRSD
Protein: Protein AFR1 (P33304)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation.
Interaction partners:
- Cell division control protein 12
- Lanosterol 14-alpha demethylase CYP51
Sequence:
MEGSYLSAQENQPIPERLIPRSNSTSNLFALSSTFSKLNVRNDADYNYSNPNKKRHIYSGEIDCRSVTAARKFPVRSCSMTAAQQRKRTALFTVRERNSYHEGFNNDQDYVSQYQKPQYTFGVYKELTPYQLQRSKMKRSFQFPNGEIYKPKLDGKCTHSLKKPELNSRDSSLFKFSEKKGRNLSKDFVGPHNGTSVIHIPPNDTGYGVNSLELNTSVPSTIKSSVSSTSPISAVNTLTSLPESQTDDDDGYENKTVTISYCFENTVNEKHGSHIEKLDLSTKEKTKPTTNSGLFDRKKKTILGTEKYRCIKSQSKLKLGSVLKKLWRTSGNSNTKHGKKDTKRRRIPIDDMVTHSDGNSEAENDIELMDANLDGIEFDDDETLMDTDSIFDDLLSKENDKYDLRRRQLEIRQKLHETSHNDDGKVSFRDTEKHNVNEGLIDKTIIEEFSKLGEYIIDTRNQPPPRSSKRPSLDDNESARYFYNISTDLRQSLSGPISLPMHVGNDMVNRLRNDWEYIRFEDRRNSLPDSSFDKVETPPKPIKKDVRFAKEVCLASTWSSNAYERANPEFIMNRHRLLWMMKVHPSMNSAMNEIKLELNSYKKNEMVVHENSKCFTHYLI
Protein: Isoeugenol synthase 1 (PhIGS1) (EC 1.1.1.319) (Q15GI3)
Organism: Petunia hybrida (Petunia)
Function: Involved in the biosynthesis of the floral volatile isoeugenol. Catalyzes the synthesis of the phenylpropene isoeugenol from coniferyl acetate. Phenylpropenes are the primary constituents of various essential plant oils. They are produced as antimicrobial and antianimal compounds, or as floral attractants of pollinators. Isoeugenol is a characteristic aromatic constituent of spices and a floral volatile compound.
Interaction partners:
Sequence:
MTTGKGKILILGATGYLGKYMVKASISLGHPTYAYVMPLKKNSDDSKLQLLKEFESLGVTIFYGELSEHDKLVAVFKEVDIVISTLAVPQYLEQLKVIEAIKEAGNIKRFVPSEFGNEVDRVRALPRFQAVLDNKKKIRRATEAAGIPFTFVSANSLTAYFVDYLLHPRQKSEQVTIYGSGDAKAVLNYEEDVAAYTIKAADDPRAANRVLIIKPPKNIVSQLDLVSSWEKTTGSTLKMTHISEQEIIKLSESINFPENIHASILHNIFIAGAQLSFELTQDHDLEASELYPNYNYTSVDEYLKICLVNPPKPKLATYAQPST
Protein: FAD/NAD(P)-binding domain-containing protein (Q38BX7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Stress-response A/B barrel domain-containing protein
- Rhodanese domain-containing protein
- Cytochrome oxidase assembly protein, putative
- Adrenodoxin, putative
- Electron transfer protein, putative
- ATP synthase subunit beta
- Mercaptopyruvate sulfurtransferase, putative
Sequence:
MYLPKQPVKVKESPFAVQKSRRFIAATGVAAFVTTAVASYFTLEKVRERQRRPDGVLLQHRNGKRVVIVGAGAAGCALAASITSACPDVHVTVIEREKKHVFHAVVPLAHVGHRSYDLNTTGGVDFLRSPATWNVTREAALVRGEVLRVDTTKNEVVVREDQEALTVTARAETSEQPSKNVLTWPMGLPSWLLGASLPPVNEHRYPYDVLVLACGAARSLGPLQKFLTGEQVDRYRIAVNPGITRDCLVHLYKGTVLHVKVPPTSFAEGATGVRSISTMRYVSRQHDGTFIGTVNTVWRYLFFFNKQKFCPYMAVTADRGPSDALPIEVNERVMDFWKQRSVNFMPCTYITHLDPRRSEATLYNYQTQQKQVVNYQLLLLDLPLVAPEFIRKSGLSRSEAAEGFAEVNPHTLQHVNHANIFAIGDCAALPTVKSYGAVFAQVPVVSHNVQQQLLHGAHGTGEMSNAAVRSRFARYDGYSSFHIVMTTWRAMWPEMTYGDWRDNLSFPTITDAPLSLTNNHIWDNLAWADVRGFLNAVYYQWFLYEVMFYFVFTRGAWYPPKWFSVPSFGDDGTML
Protein: DASH complex subunit DAD2 (Outer kinetochore protein DAD2) (Q59ZG8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:21549601, ECO:0000269|PubMed:21571923}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21571923}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:21571923}. Note=Associates with the mitotic spindle and the kinetochore (PubMed:21571923). On the spindle, localizes to the midzone (PubMed:21571923). {ECO:0000269|PubMed:21571923}.
Interaction partners:
- DASH complex subunit DAD3
- DASH complex subunit SPC19
- DASH complex subunit SPC34
- DASH complex subunit DAD1
- DASH complex subunit DAD4
- DASH complex subunit DAM1
- DASH complex subunit ASK1
- Probable kinetochore protein NUF2
- Spindle pole body component
- Histone H3-like centromeric protein CSE4
Sequence:
MSKTNTAIYQKIAEKRANLERFREFKELTDDLVLQLESIGDKLETMNGGTASVALILANWKSVVQSISLASLALMKESNDNNKEAFPEPLVRVRVGQSNEENQDEEEADEEEGVRDSEEVEESTE
Protein: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) (O54937)
Organism: Rattus norvegicus (Rat)
Function: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Ac1164
- Solute carrier family 2, facilitated glucose transporter member 4
- Stress-70 protein, mitochondrial
- Angiopoietin-related protein 4
- Peroxisome proliferator-activated receptor alpha
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Carnitine O-palmitoyltransferase 1, muscle isoform
- Putative mitochondrial transporter UCP3
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Sequence:
MKAARFVMRSASSLGNAGLVPREVELFSRYSPSPLSMKQLLDFGSENACERTSFSFLRQELPVRLANILKEIDILPEHLVNTPSVQLVKSWYIQSLMDLVEFHEKSPEDQKVLSDFVDTLVKVRNRHHNVVPTMAQGILEYKDNCTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSKTGNPSHIGSIDPNCDVVAVVEDAFECAKMLCDQYYLTSPELKLTQVNGKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENRPFLTPVEATVVLGKEDLTIKISDRGGGVPLRITDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSKEPKNLSKEKLAV
Protein: Altered inheritance of mitochondria protein 44 (Q99299)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Bud neck {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein NBA1
- Protein NIS1
- Cytokinesis protein 2
- Cell division control protein 42
- GTP-binding protein RHO1
- Nucleosome assembly protein
- Bud site selection protein RAX1
- Protein EGT2
Sequence:
MIIRAPIRTKTKSFRGDQMDFKFPSNESLPRGTLEEYHLNNHHLLNDVFAAENGVSRDEDGNSQTLSDYTSTSNTNTNSGYSSNGYYSFANISDNTTSSPRIVINQNETARLTSSDSNKSDFFASHDFPGNDSLHYSSSNVVKNQLHSMEAIPEGNITGSISTAFQTIPTADNVSYDIAPSSASSLLPRKSTSKSAILPSTQEAKPMTKLNMEKDIKTIELNNSVVPKPKKKLNRVPTIRRVESSRFSNSRYSSSVSSKSSSSRCSLKRSKAIRCKGGLLYYFTSLGIKIKKKLRKLRLVLRRRLFSYNVQKVPSATNSKTTKSKANINNKSKKRGTNLVNKNSNSTPRQKKSQRYVSNLQRSISSKSLVPVLAPQKKTKPLTVDTKFKANHPQSEDSKVGSNTPRSPLVSYTPSLRRTNSSIRRAASILTASATMTPANNKNSFISVPDNVSHAVTRNSSMYSRSRLVRSKPSTALNAIARQPSIVVENKVIPLSMNRYSIKEEDEYVIDTSSMRELSPVNSVCSSDYDRESSESYSNYADAMETTEVDNKDRVECNNEIQNVDANNEETSNEESYNLMKHYLSTVIAQRIMLRVQIARIQNYKSNVVYMNKSAETNSTIYEDLVDSLLTEYEADGSSSQIFDGVTVRADEEEEEDEDDEDDEEEEEENDDEEDEEDEEDDEDDEEEEEKRKEGEGRNLAKEVDELAELSPMRKQSDLSITLRSPFAMLNPAYSNSIISLPTGVVKRSLTLPVGMKI
Protein: Orexigenic neuropeptide QRFP (P518) [Cleaved into: QRF-amide (Neuropeptide RF-amide) (Pyroglutamylated arginine-phenylalanine-amide peptide)] (P83859)
Organism: Homo sapiens (Human)
Function: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Pyroglutamylated RF-amide peptide receptor
- Neuropeptide FF receptor 2
- Neuropeptide FF receptor 1
- Pro-FMRFamide-related neuropeptide FF
- Metastasis-suppressor KiSS-1
- Galanin peptides
- Prolactin-releasing peptide
- Pro-FMRFamide-related neuropeptide VF
- Neuromedin-U
- Neuropeptide Y receptor type 1
Sequence:
MVRPYPLIYFLFLPLGACFPLLDRREPTDAMGGLGAGERWADLAMGPRPHSVWGSSRWLRASQPQALLVIARGLQTSGREHAGCRFRFGRQDEGSEATGFLPAAGEKTSGPLGNLAEELNGYSRKKGGFSFRFGRR
Protein: Lysine-specific demethylase 4E (EC 1.14.11.66) (KDM4D-like protein) (Lysine-specific demethylase 4D-like) ([histone H3]-trimethyl-L-lysine(9) demethylase 4E) (B2RXH2)
Organism: Homo sapiens (Human)
Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
Interaction partners:
Sequence:
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRDDIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLTLGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLLMGTRSRAQGHRPQLPLANDLMTNLSL
Protein: Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1) (Q92800)
Organism: Homo sapiens (Human)
Function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:19026781}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.
Interaction partners:
- Histone-lysine N-methyltransferase EZH2
- Polycomb protein SUZ12
- Polycomb protein EED
- Histone-binding protein RBBP7
- Histone-binding protein RBBP4
- Zinc finger protein AEBP2
- Protein Jumonji
- E3 ubiquitin-protein ligase RING1
- E3 ubiquitin-protein ligase RING2
- PHD finger protein 19
Sequence:
MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL