wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor MYB20 (Myb-related protein 20) (AtMYB20) (Q9C7U7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that acts as positive regulator of abscisic acid (ABA) signaling in response to salt stress. Acts as negative regulator ABI1, ABI2 and PP2CA, which are protein phosphatases 2C acting as negative regulator of ABA signaling. Binds to the DNA specific sequence and core element 5'-ACGT-3' found in the promoters of ABI1 and PP2CA to negatively regulate their expression during ABA-dependent salt stress response.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:23660402}.
Interaction partners:
- NAC domain-containing protein 12
- NAC domain-containing protein 73
- NAC domain-containing protein 30
- NAC domain-containing protein 10
- NAC domain-containing protein 43
- Homeobox protein knotted-1-like 7
- NAC domain-containing protein 66
- NAC domain-containing protein 7
- NAC domain-containing protein 104
Sequence:
MGRQPCCDKVGLKKGPWTAEEDRKLINFILTNGQCCWRAVPKLSGLLRCGKSCRLRWTNYLRPDLKRGLLSDYEEKMVIDLHSQLGNRWSKIASHLPGRTDNEIKNHWNTHIKKKLRKMGIDPLTHKPLSIVEKEDEEPLKKLQNNTVPFQETMERPLENNIKNISRLEESLGDDQFMEINLEYGVEDVPLIETESLDLICSNSTMSSSTSTSSHSSNDSSFLKDLQFPEFEWSDYGNSNNDNNNGVDNIIENNMMSLWEISDFSSLDLLLNDESSSTFGLF
Protein: MAP3K7 C-terminal-like protein (TAK1-like protein) (P57077)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFKQHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS
Protein: Nucleolar protein 12 (Q08208)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-25S rRNA processing.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11452019, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ribosome biogenesis protein BRX1
- Periodic tryptophan protein 1
- Ribosome biogenesis protein RPF2
- rRNA-processing protein EBP2
- Ribosome biogenesis protein MAK21
- 27S pre-rRNA
- Nucleolar protein 4
- Ribosome biogenesis protein 15
- Ribosome biogenesis protein NSA1
- ATP-dependent RNA helicase MAK5
Sequence:
MSSAIDNLFGNIDEKKIESSVDKLFSSSCGPINKLEVKSKTRTVLPDSKKRERAAEADQEEKEASKPDVSDEQTEEVALPKVKKAKKSKRNDEDEDLEARYYAKLLNEEAEAEDDKPTVTKTDETSVPLTSAAKKVDFKEDELEKAERTVFIGNILSTVITSKKVYKEFKKLFGTNPIAETEESGNEKEEESSKKSDNNEFAIESIRFRSISFDEALPRKVAFVQQKFHKSRDTINAYIVYKNKSAVRKICSNLNAVVFQDHHLRVDSVAHPAPHDKKRSIFVGNLDFEEIEESLWKHFEPCGDIEYVRIIRDSKTNMGKGFAYVQFKDLQSVNKALLLNEKPMKSQKQEDENTKKPTKKARKLRVSRCKNMKKGTTIGTGLDRNGLTDSQRTRAGRAKKILGKADRATLGQEITIEGLRAKKGEGSTHLKKKKQRSATGRVTKRSIAFKKAQAEKSKK
Protein: Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (F4JRR1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for normal Golgi morphology and function (By similarity). Ensures, when in complex with FPP3/VETH1 and FPP2/VETH2, the correct secondary cell wall (SCW) deposition pattern by recruiting exocyst components to cortical microtubules in xylem cells during secondary cell wall deposition.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:O59705}; Peripheral membrane protein {ECO:0000250|UniProtKB:O59705}; Cytoplasmic side {ECO:0000250|UniProtKB:O59705}. Note=Localized at vesicle-like small compartments at cortical microtubules. {ECO:0000269|PubMed:25541219}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 5
- Conserved oligomeric Golgi complex subunit 7
- Conserved oligomeric Golgi complex subunit 4
- Conserved oligomeric Golgi complex subunit 3
- Vacuolar protein sorting-associated protein 54, chloroplastic
- Vacuolar protein sorting-associated protein 51 homolog
- Proline-rich family protein
Sequence:
MSDLVATSPSPSSAPRSATDFFSDPYDSHPLWFKPSLFLSPNFDSESYISELRTFVPFDTLRSELRSHLASLNRELVDLINRDYADFVNLSTKLVDIDAAVVRMRAPLLELREKITGFRGSVEAALFALRNGLQQRSDAAAAREVLELLLDTFHVVSKVEKLIKVLPSTPSDWQNEDANSMGRSSMNDENSTQQDGTTMRETQSMLLERIASEMNRLKFYMAHAQNLPFIENMEKRIQSASVLLDASLGHCFIDGLNNSDTSVLYNCLRAYAAIDNTNAAEEIFRTTIVAPFIQKIITHETTTNAAGTSEDELENDYKQIKHFIAKDCKMLLEISSTDKSGLHVFDFLANSILKEVLWAIQKVKPGAFSPGRPTEFLKNYKASLDFLAYLEGYCPSRSAVTKFRAEAICVEFMKQWNVGVYFSLRFQEIAGALDSALTSPSLVFIQDSDKESSLNLILRQSDTLLECLRSCWKEDVLVFSAADKFLRLTLQLLSRYSFWVSSALNNRKSNASPSPGCEWAVSATAEDFVYVIHDVNCLVSEVCGDYLGHISQYLSSSSTEVLDVVRISIEQGGVSLEKVLPLLTKTIIDVIVDKSVEDLRQLRGITATFRMTNKPLPVRHSPYVVGLLRPVKAFLEGDKARNYLTQKTKEELLHGSVSEITRRYYELAADVVSVARKTQSSLQKLRQNAQRRGGAASGVSDQNVSETDKMCMQLFLDIQEYGRNVSALGLKPADIPEYCSFWQCVAPADRQNSISV
Protein: Msh homeobox 2 (D6RIS4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEERRVKVSSLPFSVEALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPSECAPGQE
Protein: SAP30 binding protein (J3QQJ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XEPESDGEAGIEAVGSAAEEKGGLVSDAYGEDDFSRLGGDEDGYEEEEDENSRQSEDDDSETEKPEADDPKEKLGTVTEAPRAQQAHGPACWTQRAEESHSKHDKDNTEAEKRDPQELVASFSERVRNMSPDEIKIPPEPPGRCSNHLQDKIQKLYERKIKEGMDMNYIIQRKKEFRNPSIYEKLIQFCAIDELGTNYPKDMFDPHGWSEDSYYEALAKAQKIEMDKLEKAKKERTKIEFVTGTKKGTTTNATSTTTTTASTAVADAQKRKSKWDSAIPVTTIAQPTILTTTATLPAVVTVTTSASGSKTTVISAVGTIVKKAKQ
Protein: Golgi-associated RAB2 interactor protein 5A (Golgi-associated RAB2B interactor-like 5) (GARIL5) (A1L3C1)
Organism: Mus musculus (Mouse)
Function: RAB2B effector protein which promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:28930687}.
Interaction partners:
- Ras-related protein Rab-2B
- RIKEN cDNA 1700013G24 gene
- Testis expressed protein 56
Sequence:
MKGGRDLKAARGGADRPLAPAYAPCRPGRLQRHLLSGEFDQLRDFPIFESNFVQVTRFGEVANKVTMGVAASSPALELPDLLLLAGPDKENGHLQLLGLFPLQFVQLFVHDESRQQLKVKFRTGRAFYLQLRSPPETRDCEFGRWVRLLYRLRFHSPTCAVPFTHEDTAPEEEEEEEEEEEEEEVKEGQLQPPEFQATEARLDPQVSELWGL
Protein: AlkB homolog 3, alpha-ketoglutarate dependent dioxygenase (E9PSA5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPRVIEEGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPE
Protein: COMPASS-like H3K4 histone methylase component WDR5A (AtWDR5A) (Q9M2Z2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Forms multiple COMPASS-like complexes involved in histone methylation by interacting with different histone H3 'Lys-4' methyltransferases such as ATX1, SDG14 or SDG16. Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene. Up-regulates FLC and MAF4 expression to delay flowering. Present at the promoters and at the transcription start sites (TSS) regions of WRKY70 and LTP7; this occupancy is ATX1-dependent. Involved in the transition from transcription initiation to transcription elongation.
Subcellular location: Nucleus {ECO:0000269|PubMed:19567704, ECO:0000269|PubMed:21423667}.
Interaction partners:
- Protein TRAUCO
- Histone H3-lysine
- K-box region and MADS-box transcription factor family protein
- Histone-lysine N-methyltransferase ATX2
- Histone-lysine N-methyltransferase ATXR7
- Histone-lysine N-methyltransferase ATX3
- Histone-lysine N-methyltransferase ATX4
- Protein RBL
- Inactive protein FRIGIDA
- Histone-lysine N-methyltransferase ATX5
Sequence:
MAEEIPATASFTPYVHSQTLTSHNRAVSSVKFSSDGRLLASASADKTIRTYTINTINDPIAEPVQEFTGHENGISDVAFSSDARFIVSASDDKTLKLWDVETGSLIKTLIGHTNYAFCVNFNPQSNMIVSGSFDETVRIWDVTTGKCLKVLPAHSDPVTAVDFNRDGSLIVSSSYDGLCRIWDSGTGHCVKTLIDDENPPVSFVRFSPNGKFILVGTLDNTLRLWNISSAKFLKTYTGHVNAQYCISSAFSVTNGKRIVSGSEDNCVHMWELNSKKLLQKLEGHTETVMNVACHPTENLIASGSLDKTVRIWTQKKE
Protein: Small nuclear ribonucleoprotein F (snRNP-F) (Membrane-associated protein Deb-B) (Sm protein F) (Sm-F) (SmF) (Q24297)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P62306}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62306}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D3
- Probable small nuclear ribonucleoprotein Sm D2
- Probable small nuclear ribonucleoprotein G
- Probable small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein-associated protein B
- Probable small nuclear ribonucleoprotein E
- U1 small nuclear ribonucleoprotein A
- Probable U2 small nuclear ribonucleoprotein A'
- U6 snRNA-associated Sm-like protein LSm2
- U1 small nuclear ribonucleoprotein C
Sequence:
MSAGMPINPKPFLNGLTGKPVLVKLKWGQEYKGFLVSVDGYMNMQLANTEEVIEGSVTGNLGEVLIRCNNVLYIKGMEDDDEEGEMRD
Protein: Stearoyl-CoA desaturase 2 (EC 1.14.19.1) (Acyl-CoA desaturase 2) (Delta(9)-desaturase 2) (Delta-9 desaturase 2) (Fatty acid desaturase 2) (P13011)
Organism: Mus musculus (Mouse)
Function: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates. Important for normal permeability barrier function of the skin in neonates.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:16443825}; Multi-pass membrane protein {ECO:0000305|PubMed:16443825}. Microsome membrane {ECO:0000269|PubMed:16443825}.
Interaction partners:
- Fatty acid synthase
Sequence:
MPAHILQEISGAYSATTTITAPPSGGQQNGGEKFEKSSHHWGADVRPELKDDLYDPTYQDDEGPPPKLEYVWRNIILMALLHLGALYGITLVPSCKLYTCLFAYLYYVISALGITAGAHRLWSHRTYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFVLPTLVPWYCWGETFVNSLCVSTFLRYAVVLNATWLVNSAAHLYGYRPYDKNISSRENILVSMGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMALLGLAYDRKRVSRAAVLARIKRTGDGSCKSG
Protein: Epithelial sodium channel subunit beta (Amiloride-sensitive sodium channel subunit beta) (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (H1AFJ6)
Organism: Neoceratodus forsteri (Australian lungfish) (Ceratodus forsteri)
Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:P51168}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51168}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P37090}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51168}.
Interaction partners:
Sequence:
MFLKRWFIRALHRLQKGPGYGYSELFVWYCNNTNTHGPKRLIIEGPKKKTLWSLFTVTFACLVFWQWGLLIQTYLSWGVSVSLSVGFRGMDFPAVTVCNVNPFKYSKVKPLLKELDELVDILLEQFYSYSTNGTLPVVFPDMRSSYLTGDPPPWYQIPLVMIDETDADNPTVTNVLGTDALSPTNNSTTNSSTEARRYKVAFHLCNTNGTDCFYKNFSSSLEAVKEWYTLQYIDIISKLPLSQKVEMGYSGKDFILTCLFGGEACNYDNFTQFYHSSYGNCYVFNWGLDGNVLIVSNPGVGFGLQLALDVNQEEYIPFLTTRAGARFLLHTQNTFPFVETMGTYALVGTVTSVGILVDEVQRMGQPYGTCTTDGLDVPIDNLYSQYNLSYTMQSCLWSCFQIQMVNSCGCAYYLYPLPEGATYCNNQNNSDWAYCYYLLQDSKDHKNECLQTCIQTCNELQFRISTSMADWPSESSEDWIFHVLSYERDDSTNITMKRDGVLKLNLYFKEFNYRVITESVATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEVFIDCIWIAVIRFVKWYKNRKERQVQAQYADPPPTVSELVEGYTNQGFQPDIINSCSPQAQPPDLYLPTTLEIPGTPPPKYDSLRVHPIDTEHHSDSEDL
Protein: Ubiquitin carboxyl-terminal hydrolase UCH54 (EC 3.4.19.12) (PfUCH37) (PfUCH54) (Q8IIJ6)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8.
Interaction partners:
- 26S proteasome regulatory subunit RPN10, putative
- 26S proteasome regulatory subunit RPN13, putative
- 26S proteasome regulatory subunit RPN12, putative
- 26S proteasome regulatory subunit RPN1, putative
- Proteasome subunit alpha type-1, putative
- 26S proteasome regulatory subunit RPN6
- 26S proteasome regulatory subunit RPN8, putative
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit RPN9, putative
- 26S proteasome regulatory subunit p55, putative
Sequence:
MARDNENILEEWCLIESNPCIFYDMLKRMGATEISVEDVYSLSYFDDYINNKEIINMNHILGVDTYLGENNKTLDKENNVVDVIELYKNNICMEDKYNKLLKHHSYIYGIIFLFNIGKHYKNNKYIEHNVPDNLFFAKQVIPNACATQAILSIVLNKDIELNDEIKNIKTFSLNFDSSMKGLTLSNCTFLRNIHNSYKPPIYLDKEDVHHDKKKSEDSFHFVSYISFQDKVYLLDGLQSGPVLINADEQNKPNPNNNNNNKDNDNDNNNNNNNNNNNNNNNNNNNNNNNNNNIGMNGKDWIEISREHIKKEIDEICNSQTNNDVRFNIIAVMKDKEYIIQEYINIHRIVKQRVNIKLINLGENIELSDEINEDEFPLLNDIPSIENLPNNVDTLYNIVNKSTLEINYLQSLLHEQKEIKKLWNKELTFKFFNFYPFIMSSLNLMAKHKLLKDAYQKEKLKNATKS
Protein: Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B) (Q58DZ9)
Organism: Rattus norvegicus (Rat)
Function: May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20152115}; Single-pass type II membrane protein {ECO:0000269|PubMed:20152115}. Early endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Postsynaptic density membrane {ECO:0000269|PubMed:26660156}. Synapse {ECO:0000269|PubMed:20152115}. Cell projection, dendrite {ECO:0000269|PubMed:20152115}. Cell projection, dendritic spine {ECO:0000269|PubMed:20152115}. Note=Shuttles between the cell surface and early endosome membrane. {ECO:0000250}.
Interaction partners:
- Protein cornichon homolog 2
- Glutamate receptor 1
- Proline-rich transmembrane protein 2
Sequence:
MDGIVEQKSVLVHSKIGDAGKRNGLINTRNFMAESRDGLVSVYPAPQYQSHRLVASAAPGSLEGGRSDPVQQLLDPNTLQQSVDSHYRPNIILYSDGVLRSWGDGVATDCCETTFIEDRSPTKDSLEYPDGKFIDLSGDDIKIHTLSYDVEEEEELQELESDYSSDTESEDNFLMMPPRDHLGLSVFSMLCCFWPLGIAAFYLSHETNKAVAKGDFHQASTSSRRALFLAVLSITIGTGIYVGVAVALIAYLSKNNHL
Protein: Putative ATPase Rv3679 (P9WKX5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- ATPase BagB
- Uncharacterized protein Rv1509
- Transcriptional activator protein
- DUF4177 domain-containing protein
- Possible hydrolase
- Conserved protein
- Uncharacterized protein Rv0487
- Conserved protein TB16.3
- Cyclase
- Glycerol kinase
Sequence:
MVATTSSGGSSVGWPSRLSGVRLHLVTGKGGTGKSTIAAALALTLAAGGRKVLLVEVEGRQGIAQLFDVPPLPYQELKIATAERGGQVNALAIDIEAAFLEYLDMFYNLGIAGRAMRRIGAVEFATTIAPGLRDVLLTGKIKETVVRLDKNKLPVYDAIVVDAPPTGRIARFLDVTKAVSDLAKGGPVHAQSEGVVKLLHSNQTAIHLVTLLEALPVQETLEAIEELAQMELPIGSVIVNRNIPAHLEPQDLAKAAEGEVDADSVRAGLLTAGVKLPDADFAGLLTETIQHATRITARAEIAQQLDALQVPRLELPTVSDGVDLGSLYELSESLAQQGVR
Protein: Molybdate transporter 1 (A6YCJ2)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: High affinity molybdate transporter. Acts through an energy-dependent process.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MALQNAWQNTKERARETWAQLTWSEVSGSLGDLGTFLPLLIGLVQKVHLDLGTTLTITGLYNIISGWQFRIPMCVQPMKTIAAVALAGGAAGLDLPQLLHAGLFVAGCVGLLGASQAIDLFNWLVPPPVIRGVQLAVGVKLAMKGVDMALRLHGGPSSGWRPWLGTEGLVVGAVALAAMIATTLPPRAARRGTLEAADEGGLGPRPTDTAFEPLLRRLPACCGGGDRAPQVEGAAVSAERAGLLAHAEGGERSGNLDDGTEAGVGAAAGGGGCGGGGGGGRIPSALIAVVVGLAMAVLHRPGLVWELRLGPTLPRLLRPSWPDFKTGALRGGLPQLPLTTLNSVIAVTQLANALFGDKPEAERRRWRPSAVALSVALLNGAGVWLGAMPCCHGAGGLAAQYKFGARTGHAPILLGCIKAALGLLFGGSLVVLLEAFPQPLLGALLTVSGIELASVVRHTRSPRGYTFALLTAVAILALDNTGTGFLVGLVGVAAVAAYEGAVAAAAARWPRVFARGGRA
Protein: Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) (P09034)
Organism: Rattus norvegicus (Rat)
Function: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure.
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:19491403}.
Interaction partners:
- Argininosuccinate lyase
- Ornithine transcarbamylase, mitochondrial
- Carbamoyl-phosphate synthase, mitochondrial
- N-acetylglutamate synthase, mitochondrial
- Multifunctional protein CAD
- Ornithine aminotransferase, mitochondrial
- Asparagine synthetase
- Nitric oxide synthase 3
- Nitric oxide synthase, inducible
- Nitric oxide synthase 1
Sequence:
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSKEFVEEFIWPAVQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELTCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKSPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDVLEIEFKKGVPVKVTNVKDGTTHSTSLDLFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIDKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPIDATGFININSLRLKEYHRLQSKVTAK
Protein: Small ribosomal subunit protein mS37 (37S ribosomal protein MRP10, mitochondrial) (YmS-T) (O75012)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095}. Mitochondrion matrix {ECO:0000269|PubMed:24360785}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein mS23
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein bS1m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein mS33
- Small ribosomal subunit protein mS42
- Small ribosomal subunit protein uS8m
- Small ribosomal subunit protein bS21m
Sequence:
MSGKPPVYRLPPLPRLKVKKPIIRQEANKCLVLMSNLLQCWSSYGHMSPKCAGLVTELKSCTSESALGKRNNVQKSNINYHAARLYDRINGKPHD
Protein: Myoglianin (Q9XZ62)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLANSCCGWRKYKTHDQHHRTLKKKTRQNTSDTTVHIEVNSNEIQFPGSYRFNLDSKKINIGRMNILGHKRGNFRVTRYVTVTVLLILSTAVNAYAQPENKSFSNSSNNDSPEMVMLSNETNNSAKVLSEKNGSSSISADDKINENMGIFQMKVQSKPGKKSTPLAKVSEHGDLSRVQSVSLYRNTLINIESMLQRQLREKAKVDSIESIKMHILMRLNLKKLPNITKPISVPQNIIDNFYRDYNASSKTTVWNRMESIDEFHLSINDTYGDHIMTDFFDESSSSQMQGDDANTVNEFLIDLNKNQAKKSDIPINTNDEEYESILSHISSIYIFPEEIQPHVRHNRKVDVFRFQIDSSYSDLSYATLHLYLRGWDWISAHQPGLLEEIKKQPRKDIVVTIHRAIRVANTTSFNPKVKMFEFRHSIPSGLGQWVAVDLKSLLGNLGSNMTQEILIKGAETWMKSLVVTTDNTSKNPLTVHIEIGSQKKHRRKRSVYMDCTENDHDMRCCRYPLKVNFTSFGWHFVVAPTSFDAYFCSGDCKVGYLEQYPHTHLAALTTSATPCCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGCSCS
Protein: Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B) (P63146)
Organism: Homo sapiens (Human)
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P63149}. Nucleus {ECO:0000250|UniProtKB:P63149}. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei. {ECO:0000250|UniProtKB:P63149}.
Interaction partners:
- E3 ubiquitin-protein ligase RAD18
- E3 ubiquitin-protein ligase BRE1A
- E3 ubiquitin-protein ligase BRE1B
- Ubiquitin-like modifier-activating enzyme 1
- E3 ubiquitin-protein ligase UBR1
- Ubiquitin conjugating enzyme E2 V1
- Ubiquitin-conjugating enzyme E2 A
- E3 ubiquitin-protein ligase UBR2
- Ubiquitin-conjugating enzyme E2 variant 2
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWNDS
Protein: Pectin acetylesterase 9 (EC 3.1.1.-) (B9DFR3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.
Subcellular location: Secreted, cell wall {ECO:0000305}.
Interaction partners:
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Pectin lyase-like superfamily protein
- Protein REDUCED WALL ACETYLATION 4
Sequence:
MKTTTRLLDLTAAMVLVVYVSFSPPLVSGEPGRRVSMTLVRDAAALGAFCLDGSLPAYHLDRGFGAGSNNWILQFEGGGWCNDIASCVERAKTRRGSTRYMSKTVVFTGVLSNNASQNPDFYNWNKVRLRYCDGASFAGDSQFGNGTSLLYFRGQRIWNAIILDLLPKGLAKAHKALLTGCSAGGLSTFLHCDNFTSYLPKNASVKCMSDAGFFLDAIDVAANRTMRSFYSQLVSLQGIQKNLDPSCTHAFFPEPSLCFFPQYVLRFIKTPFFILNSAYDVFQFHHGLVPPSADQTGRWNRCKLNVTACNPHQLDALQGFRKDMLGALMNFFRNSTRGGMFINSCFDHCQSALEETWLSPTSPRINNKTIAETVGDWYFGRGEEAKEIGCPYPCDKTCHNLIPASTSDFLASNASGSGHNSRGTHLTFLFLLLNFFFFFVISKFSKKDYVT
Protein: Prophage LambdaSa1, lysin, putative (Q8E0W3)
Organism: Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Interaction partners:
- Uncharacterized protein
- Prophage LambdaSa2, holin
- Prophage LambdaSa1, pblA protein, internal deletion
- CD1375-like domain-containing protein
- DUF1366 domain-containing protein
- Prophage LambdaSa1, N-acetylmuramoyl-L-alanine amidase, family 4
Sequence:
MVINIEQAIAWMASRKGKVTYSMDYRNGPSSYDCSSSVYFALRSAGASDNGWAVNTEYEHDWLIKNGYVLIAENTNWNAQRGDIFIWGKRGASAGAFGHTGMFVDPDNIIHCNYGYNSITVNNHDEIWGYNGQPYVYAYRYARKQSNAKVDNQSVVSKFEKELDVNTPLSNSNMPYYEATISEDYYVESKPDVNSTDKELLVAGTRVRVYEKVKGWARIGAPQSNQWVEDAYLIDATDM