wanglab/gogpt-training-data huggingface dataset:
Protein: Electrogenic sodium bicarbonate cotransporter 4 (Solute carrier family 4 member 5) (Q6RI88)
Organism: Rattus norvegicus (Rat)
Function: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:15151908}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9BY07}; Multi-pass membrane protein {ECO:0000255}. Note=Localized predominantly to the basolateral sinusoidal membrane in hepatocytes. {ECO:0000269|PubMed:15151908}.
Interaction partners:
Sequence:
MKVEEKAGVKKLEPTSYRRRHPEQDFPSIHIGFPVPGYSQRKSDSKGHLSGLQRVQWSLQPDKSQQDLAGPDGIKASSLGGSVDFTKRIRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEGGLLRPELRERVSYVLLRKHRHQTKKPIHRSLADIGKSVSTTNRSSARSPSAGPTLHHSTEDLRIRQSTSYGHLCHAQSRSMNDISHTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLAQSSMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGVDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGRSGASAGGGGSGGGAGGSGAGGGGSGNEAEMPAMHEIGEELIWTGRFFGGLRLDVKRKLPWFPSDFYDGFHIQSISAVLFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKANGLDYMEFRLWIGLHSAIQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINTDFKPDSITTYKCECVAPDTVNTTTVNDSALLVPNTNMSVYTPLNLTALDWSLLSKKECLSYGGRLLGSSCQFVPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRTLVADFSIVFSILLFCGIDACFGLQTPKLHVPNVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLRKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGVMVFILTGISVFLAPILKYIPMPVLYGVFLYMGVASLNGIQFWDRCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLALLWILKSTMAAIIFPVMILGLIIVRRLLDLIFSQHDLAWIDNILPEKEKKESDRKKRRKEVHENTDKEPQFLPPSVVKIPMEGIPSDPQNGIHCVGRKRSSSWSHSL
Protein: Protein HAIKU1 (MPK3/6-targeted VQ-motif-containing protein 9) (VQ motif-containing protein 14) (AtVQ14) (O82170)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates seed size by negatively regulating the cellularization of syncytial endosperm. May function by binding and modulating the activity of WRKY10 transcription factor.
Subcellular location: Nucleus {ECO:0000269|PubMed:20545893}. Note=Expressed both in the unfused polar nuclei and in the fused polar nucleus in the central cell before fertilization, in the syncytial endosperm after fertilization and in the endosperm nuclei. {ECO:0000269|PubMed:20545893}.
Interaction partners:
- Probable WRKY transcription factor 10
- Receptor-like protein kinase HAIKU2
- Phosphate transporter PHO1 homolog 4
- VQ motif-containing protein 18
- VQ motif-containing protein 8, chloroplastic
- VQ motif-containing protein 29
- VQ motif-containing protein 22
- VQ motif-containing protein 17
- Sigma factor binding protein 2, chloroplastic
- Calmodulin-binding protein 25
Sequence:
MDRPRQNDHLGVNRIGKNIRKSPLHQSTFAASTSNGAAPRLQTQPQVYNISKNDFRSIVQQLTGSPSRESLPRPPQNNSLRPQNTRLQRIRPSPLTQLNRPAVPLPSMAPPQSHPQFARQPPHQPPFPQTTQQPMMGHRDQFWSNTAESPVSEYMRYLQSSLGDSGPNANQMQPGHEQRPYIPGHEQRPYVPGNEQQPYMPGNEQRPYIPGHEQRSYMPAQSQSQSQPQPQPQPQQHMMPGPQPRMNMQGPLQPNQYLPPPGLVPSPVPHNLPSPRFNAPVPVTPTQPSPMFSQMYGGFPSPRYNGFGPLQSPTSQFLQPSPTGYPNMFSPRSPYPLLSPGVQYPQPLTPNFSFSQIAQQGSLGPGAGPSQGPPQPPPSPGLMFPLSPSGFFPMPSPRWNDY
Protein: Claudin domain-containing protein 1 (Claudin-25) (Q9CQX5)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPIQENSSDSNKIAWEDFLGDEADEKTYNDVLFRYNGSLGLWRRCITIPKNTHWYAPPERTESFDVVTKCMSFTLNEQFMEKYVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTLATGILHLLAGLCTLGSVSCYVAGIELLHQKVELPKDVSGEFGWSFCLACVSAPLQFMAAALFIWAAHTNRKEYTLMKAYRVA
Protein: Psmc6 protein (Q32PW9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
LQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV
Protein: Zinc finger protein 655 (Vav-interacting Krueppel-like protein) (Q8N720)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MEEIPAQEAAGSPRVQFQSLETQSECLSPEPQFVQDTDMEQGLTGDGETREENKLLIPKQKISEEVHSYKVRVGRLKHDITQVPETREVYKSEDRLERLQEILRKFLYLEREFRQITISKETFTSEKNNECHEPEKSFSLDSTIDADQRVLRIQNTDDNDKYDMSFNQNSASGKHEHLNLTEDFQSSECKESLMDLSHLNKWESIPNTEKSYKCDVCGKIFHQSSALTRHQRIHTREKPYKCKECEKSFSQSSSLSRHKRIHTREKPYKCEASDKSCEASDKSCSPSSGIIQHKKIHTRAKSYKCSSCERVFSRSVHLTQHQKIHKEMPCKCTVCGSDFCHTSYLLEHQRVHHEEKAYEYDEYGLAYIKQQGIHFREKPYTCSECGKDFRLNSHLIQHQRIHTGEKAHECNECGKAFSQTSCLIQHHKMHRKEKSYECNEYEGSFSHSSDLILQQEVLTRQKAFDCDVWEKNSSQRAHLVQHQSIHTKENS
Protein: leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (A0A6I8PLB3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
Protein: Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8) (Q15024)
Organism: Homo sapiens (Human)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
Interaction partners:
- DIS3-like exonuclease 1
- Exosome complex component RRP41
- Exosome complex component RRP43
- Exosome complex component MTR3
- Exosome complex component RRP46
- Exosome complex exonuclease RRP44
- Exosome complex component 10
- Exosome complex component RRP45
- Exosome complex component CSL4
- M-phase phosphoprotein 6
Sequence:
MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG
Protein: Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))] (P02652)
Organism: Homo sapiens (Human)
Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Subcellular location: Secreted {ECO:0000269|PubMed:24116940}.
Interaction partners:
- Apolipoprotein C-III
- Apolipoprotein B-100
- Apolipoprotein E
- Apolipoprotein A-I
- Apolipoprotein C-II
- Apolipoprotein A-IV
- Apolipoprotein D
- Apolipoprotein C-I
- Beta-2-glycoprotein 1
- Phosphatidylcholine-sterol acyltransferase
Sequence:
MKLLAATVLLLTICSLEGALVRRQAKEPCVESLVSQYFQTVTDYGKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPATQ
Protein: GHMYB25 (Q9ATD4)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRSPCCEKVGLKKGPWTPEEDQKLLAYIEQHGHGSWRALPLKAGLQRCGKSCRLRWINYLRPDIKRGKFSLQEEQTIIQLHALLGNRWSAIATHLPKRTDNEIKNYWNTHLKKRLTKMGIDPVTHKPKTDALGSTTGNPIDAANLSHMAQWESARLEAEARLVRESKLVPSNPPQSNHFTAVAPSPTPATRPQCLDVLKAWQGVVCGLFTFNMDNNNLQSPTSTLNFMENTTTLPMSSSSSVNGMFNENFGWNSSINPCESGDILKVEYGSDQIPELKERLDHPMELHEMDCSSEGTWFQELFGFNGL
Protein: Melanoma-associated antigen 6 (Cancer/testis antigen 1.6) (CT1.6) (MAGE-6 antigen) (MAGE3B antigen) (P43360)
Organism: Homo sapiens (Human)
Function: Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.
Interaction partners:
- Melanoma-associated antigen 3
- Melanoma-associated antigen 12
- Chondrosarcoma-associated gene 1 protein
- Cancer/testis antigen 2
- Cancer/testis antigen 1
- Melanoma-associated antigen 1
- Transcription intermediary factor 1-beta
Sequence:
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAKLVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASDSLQLVFGIELMEVDPIGHVYIFATCLGLSYDGLLGDNQIMPKTGFLIIILAIIAKEGDCAPEEKIWEELSVLEVFEGREDSIFGDPKKLLTQYFVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHMVKISGGPRISYPLLHEWALREGEE
Protein: Putative metal ion transporter C17A12.14 (O13779)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Stretch-activated cation channel yam8
- Mitochondrial inner membrane magnesium transporter mrs2
Sequence:
MPSNTSRSVPTGFYYKQNARMQNRPRFSDRKHSSKSKHRFPVDPSLQPDEADEGTRLLGNSDSDLLEPPSEHSSNGEDDKDINNPPSMPSSVCSSPKSPHRHYESDEDIENISLPESHPEDIQRKEFETENGKNTRDQPSPLAEVSDFAISSPHVYPKSANSHDSHYEQFANNDVTESAVDDHPATRKLSRDELYLPISPNNAQEPKFSVLDEWTKKMVANFEEYSVEDVDKRRERNRKLSEPLLVNGRYRVRDRWAQFRKSEIEKPYRFTFFTDELPSTIHSHEMWELVHDGQSFEDLFHSGGTWWLDVSCPKEEEIRVLAKAFGIHPLTVEDITLEEDREKVELFRTYYFVTFRSFNQLPSNSEYLKPLNFYLVVFRDGIITFHMNPTPHPANVRRRIRQLNGYLTVNADWIAYALLDDTTDAFAPFIEQIEDEVDTIDSMILSIHYDHVMEVKPQERMLQRVGECRKLIMSLLRLLANKADVVRGLSKRCNESWQVAPRGEIALYLGDVQDHIVTMVQNLNHYEKILSRSHSNYLAQISINMTLVSNETNEVLSRLTILGTILIPLNLVTGLWGMNVKVPGQDVPGLGWFFSILGSLMIFAISSFILCKWYKVI
Protein: Homeobox protein Nkx-2.1 (Putative transcription factor NK2.1b) (Q98TX4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MSMSPKHTTPFSVSDILSPLEESYKKVSMEGNNLGAPLASYRQPQVTQAAMQQHHMGHNGTVPAAYHMTAAGVSQLSHTAMGGYCNGNLGNMSDLPAYQDGMRGSTTATSWYGTNPDPRFSTISRFMGSSSGMNMGSMSTLSSLADVGKGMGPLTSTPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKVSQQQMQQDNGSCQQQQQSPRRVAVPVLVKDGKPCQGSSHTPNTGVQNHHHQGGNVMFMTNTSLSMSQHQSQQVGSAGQSLDLGQHAASPPSLQTQVPGLSHLNSSGSEYGAALPCSALLYGRTW
Protein: Glucan endo-1,3-beta-D-glucosidase 2 (Endo-1,3-beta-glucanase 2) (EC 3.2.1.39) (Laminarinase-2) (Q12168)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cleaves internal linkages in 1,3-beta-glucan.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12455695}.
Interaction partners:
- Reduced viability upon starvation protein 167
- Protein YSC84
Sequence:
MCYSRQAIPPPVPNRPGGTTNRGPPPLPPRANVQPPVCSSENSSKPRENRVAGESLRTPSSSNPLADSQVNSDNIFQSPVLSNLKAPPSVFNKVQHPVPKPNIDDQSVDPLETNKFYTNMLLDDNTQPIWTHPYSIWFSRDPELFGLAANHTLASQRVFDTTTNPPRFYFNPTNIKSFVFKAREFVSSNDIKLEFRDMKHMSMCLLMSLSSSQFIEFPLVQGMGFVTAIYHDLGFELRSAVGFRSLERISVNERYGKYNIQLENNRNWILYLTSPDYSFPQDFQISLLDSNTIISSHKINGLICQLSADSVPSIDMAAGCYPVYCDLSGQTVDEHFTNYRFNYTVAGYSQSGTTLMYALPHHKAAFTPEMQEREIASSLDSTVKGLMTGYLTNSFDMQVQVPQELGFEPVALSLNKKADYSQEKLSKIREAAVQEVQLSDPQQESNIDSMYFSGKILAKYAWILYVTHYILHDENLTKELLSKLTIAMERFISNQQVLPLNYDVSWKGIISSGSSSQDFGNSYYNDHHFHYSYHVITAAIISLVDSDLSGVTNNSWLENNRDWVECLIRDYSGVDNDDPYFPQFRSFDWFNGHSWAKGLFPSGDGKDEESTSEDVNSCYAIKLWGLVTGNSKLTDIANLQLGIMRNVFQSYFLYESNNTVQPKEFIGNKVSGILFENKIDHATYFGMEPQYIHMIHAIPITSASSWVRTPNFVKEEWEEKMQPIIDQVNDGWKGIIMLNMALLDPKFSYDFFSQPDFNRNFLDNGQSLTWSLAYSGAFS
Protein: Natural killer cell receptor Ly-49P3 (Natural killer cell receptor Ly49P3 isoform) (Q9EP94)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MSEQEVTFSTVRFQKTSGLQNRVRLEETLKPRKAGLRGRGDKVYWFCYGRKCYYFVMDRKPWSGCKQTCQSSGLSLLKIDDEDELKFLQLVVPSDVCWIGLSYDNKKKDWSWVDNGPSKLALNTRKYNIRDGGCMLLSKTRLDNGNCDQVFICICAKRLDKFPH
Protein: Small nuclear RNA activating protein 3 (Q38AQ6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQQRLVLIATDFVTLYQEALSRQLLTPAALTPDAFKDLFDRINVEYMHYAGAGATQPYFEDVVENLLQLAAAYITLPPDAAPNSRAFGVYLTFFLYATQPAIETSPVKVQISLGTLQRYVEDIDSTARDNQGVITSLGCRVSDGEKRLLLALHKSGALKVMPFIDDSLYVRTLIEVHEQAGLPLLTCVAPQRSNPSPHIALEGGTCVDDDLSNQLHAYREMRRRINTESLLKRK
Protein: Transcription factor MafB (Maf-B) (Transcription factor Val) (Valentino) (Q98UK5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- Early growth response protein 2b
- Homeobox protein Hox-B1a
- E3 SUMO-protein ligase EGR2a isoform 1
- Protein c-Fos
Sequence:
MSADLAMGPELPTSPLALEYVNDFDLMKFEVKKEAMAAHDRANIRQCNRLQPQGSVSSTPISTPCSSVPSSPSFSPTEQKNHLEELYWMPSGAYPQQIDPQTLSLTPEDAVEALIGATAHGHPPPPHVQQQLQAGAFDGYRGAHHHHGHAQQQQQQQPQHHHHQHQYGAIPHHPDDLSGHPGAHGHHPHHHHHHHHSQDPDSPSPTSPEQLHHRHHHHHHPHGHPGQQGHHGVGGGLNVEDRFSDDQLVTMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRFKRVQQKHLLENEKTQLINQVEQLKQEINRLARERDAYKLKCEKLTGANGFREAGSTSDNPSSPEFFM
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (Q90ZF0)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
ASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVE
Protein: Geranylgeranyl diphosphate reductase, chloroplastic (EC 1.3.1.83) (Geranylgeranyl reductase) (Q9CA67)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the reduction of geranylgeranyl diphosphate to phytyl diphosphate, providing phytol for both tocopherol and chlorophyll synthesis.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:22212719}.
Interaction partners:
- Chlorophyll synthase, chloroplastic
- Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic
- Solanesyl diphosphate synthase 2, chloroplastic
- Solanesyl diphosphate synthase 1, chloroplastic
- Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 1, chloroplastic
- Magnesium-chelatase subunit ChlH, chloroplastic
- Homogentisate phytyltransferase 1, chloroplastic
- Heterodimeric geranylgeranyl pyrophosphate synthase small subunit
- Putative geranylgeranyl pyrophosphate synthase 8, chloroplastic
- Geranylgeranyl pyrophosphate synthase 7, chloroplastic
Sequence:
MATTVTLKSFTGLRQSSTEQTNFVSHVPSSLSLPQRRTSLRVTAARATPKLSNRKLRVAVIGGGPAGGAAAETLAQGGIETILIERKMDNCKPCGGAIPLCMVGEFNLPLDIIDRRVTKMKMISPSNIAVDIGRTLKEHEYIGMVRREVLDAYLRERAEKSGATVINGLFLKMDHPENWDSPYTLHYTEYDGKTGATGTKKTMEVDAVIGADGANSRVAKSIDAGDYDYAIAFQERIRIPDEKMTYYEDLAEMYVGDDVSPDFYGWVFPKCDHVAVGTGTVTHKGDIKKFQLATRNRAKDKILGGKIIRVEAHPIPEHPRPRRLSKRVALVGDAAGYVTKCSGEGIYFAAKSGRMCAEAIVEGSQNGKKMIDEGDLRKYLEKWDKTYLPTYRVLDVLQKVFYRSNPAREAFVEMCNDEYVQKMTFDSYLYKRVAPGSPLEDIKLAVNTIGSLVRANALRREIEKLSV
Protein: Sobremesa, isoform B (Q8IR48)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- alpha-glucosidase
- alpha-glucosidase
Sequence:
MRDKISQLFCLQKNACKNNSTDNNRGHNVPTKTTSNGTMCANGSLGTEGPEAPETDSSGTGRMRKPLERNGSTQNHVVHLERRLGLFSGVALIVGTMIGSGIFVSPSGLLVRTGSVGVSFIIWLACGVLSLLGALAYAELGTMNTSSGAEWAYFMDAYGPAPAFLFSWVSTLVLKPSQMAIICLSFAQYAVEAFVTECDPPRGVVKMVALVAIVMILFVNCYSVNLGMAVQNVFTAAKLVAVVVVICGGAWKLMQGNTQHLSNAFNGPMPNVGAIATAFYTGLWAYDGWNNLNYVTEEIKNPSKNLPRSIIIGIPLVTLCYALINISYLAAMSPQEMIESEAVAVTFGNRILGALAWLMPLSVTISTFGSANGTLFAAGRLCFAASREGHLLDILSYVHVRRLTPAPGLIFHSLIASAMVLHGTIDSLIDFFSFTAWIFYGGAMLALIVMRYTKPNYPRPYKVPIIIPVVVLVISVYLVAAPIFETPRVEYLYALLFIFAGLIFYVPFVKLGMTPRFMNKVTLFFQLLLEVVPTSSMAMFE
Protein: Chromatin remodeling protein SHL (Protein SHORT LIFE) (Q9FEN9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Chromatin remodeling factor that binds to methylated histone (e.g. H3K4me2/3) to prevent their acetylation (e.g. H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulate the transcription of target genes. Required during development and for fertility, probably by modulating developmental gene expression. Promotes development speed, but at fitness cost. Involved in the chromatin-mediated repression of floral initiation and controls genes regulating flowering. Negatively regulates the expression of the floral integrator SOC1, by preventing high levels of H3 acetylation, thus maintaining an inactive chromatin conformation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:11129039}.
Interaction partners:
- PHD finger family protein / SWIB complex BAF60b domain-containing protein / GYF domain-containing protein
- Cysteine/Histidine-rich C1 domain family protein
- PHD finger protein MALE MEIOCYTE DEATH 1
- Zinc ion binding / DNA binding protein
- PHD finger protein ALFIN-LIKE 5
- PHD finger protein MALE STERILITY 1
- Staphylococcal-like nuclease CAN2
- Protein TRAUCO
- Protein RBL
- Protein OBERON 2
Sequence:
MPKQKAPRKQLKSYKLKHINKSIQEGDAVLMRSSEPGKPSYVARVEAIETDARGSHAKVRVRWYYRPEESIGGRRQFHGAKEVFLSDHFDFQSADTIEGKCKVHSFSSYTKLDSVGNDDFFCRFEYNSTTGAFDPDRVTVFCKCEMPYNPDDLMVQCEECSEWFHPSCIGTTIEEAKKPDNFYCEECSPQQQNLHNSNSTSNNRDAKVNGKRSLEVTKSKNKHTKRPG
Protein: E3 ubiquitin-protein ligase Iruka (EC 2.3.2.27) (Q9VHI7)
Organism: Drosophila melanogaster (Fruit fly)
Function: E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates. Recognizes miRNA-empty Ago1 and triggers its degradation via polyubiquitination independently of the Bag6 complex. By targeting miRNA-empty Ago1, eliminates dysfunctional Ago1 not able to bind miRNA and thereby plays a role in the quality control of miRNA-mediated silencing.
Interaction partners:
- Large proline-rich protein BAG6
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MAEAMVVEDRPAEAKRFFCHMCNVEINIPNSDFTCPLCANGFVEELPANAPEMDSSTAGASGSARSGSSGSGSSGSHDTLSRGSSSSGSQVNVESLRNDIVSLLNMRNVPNLEITIEPNRRHSNVLHLGGFGGPSGSDSARGLTAGGRVRPANLDRLDNVLFDFLQSLPLAGATAEIVTGPGGGGVGGGGNSHMFFMGNPGDYAWGREGLDTIVTQMLNQMETSGPPPLSAQRINEIPNVQINAEEVNRKIQCSICWDDFKIDETVRKLPCSHLYHENCIVPWLNLHSTCPICRKSLADDGNDADDEFVMLDAFGPEMAADGSNSERRSASTATGTDNPSPANNPSQAAAEGGRTRPDANPAQAARNNIFTFDDDNMFLD
Protein: Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) (P07737)
Organism: Homo sapiens (Human)
Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Vasodilator-stimulated phosphoprotein
- Actin, cytoplasmic 1
- Cofilin-1
- Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
- Exportin-6
- Actin, cytoplasmic 2
- Actin nucleation-promoting factor WAS
- Vinculin
- Actin, alpha skeletal muscle
- Protein diaphanous homolog 1
Sequence:
MAGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLVGKDRSSFYVNGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKTDKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
Protein: Receptor-transporting protein 5 (3CxxC-type zinc finger protein 5) (CXXC-type zinc finger protein 11) (Q14D33)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDRAGADMWASTFTLAMAERKPQDVWVLLPEHSLVPGCLDGGGVQYLLVGLSRLQCGHCPGTWDSAHVHVLFHLWWDRASHRGLVKMRIWGQRCRLCPAPGDCQVRPPGEQPFLSRLVLHILQDCYGDGPGPARHPREAYEGCCEACELGVCFLQKAPDPAWSANATKGNFPATAWGGTGTVSRGKPLSTPGDDLGKGGVVIAIPFSLVGTSNDQVPIAEGPAPPAGASLPVTGSCEALVIGQGSIFLSGDSVAMPGGKGFPVAIGDPLFHGPGLLGSSIQTFELKGFLFKGRGSLCSPVGVAQGWGPISLNNGLVPVGKHTPTVFYCVGLSASGEGSLTFPSSLTSIFTNTLSEPTDGPVATKEASITFPFIFTDVKDAVAEVAEGNGKEGGGQGLVPVGHDALPETNAGGLPSQVKGSLALPFPADVQGKDAFTDITEGKEKEGGLVTAGHDAPLEANAEGPITVSEGCITIPFAVFDVIKRKGGGHVAYGPQGNGCFSQGYYQKRQLRSRFHKARCGCRREEDERPGRACRRPHAEPYEDFWIWVSMTVCVFWLMCMCRLNPGIYPQQV
Protein: Phospholipase (EC 3.1.4.4) (A4UZ54)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037868}; Lipid-anchor {ECO:0000256|ARBA:ARBA00037868}.
Interaction partners:
Sequence:
MADAGTVGGALPPYALTNSDEEHGSGEEDASEENSNNEEGEGVFRDCTDEAVVEHHNRCLPEFQFSLVDSEYDETLAFPDSVTILSNVGDKPVLVERKETDDDEEEFDDEENNSVVLRHEIPFTSIYGPSVKFNSFQRKVFIPGREIHVRIVDTERSVTTHLLNPNLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRTSLNIPFPSRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAMAMISPNHSSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNLLNISLYRSHHETGKEGVILKRTGSTRPGQAGCNFFGCFQKNCCVRCNYFCSDVVCGTWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHIVLKCWTRRKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAALEEIYIADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKSTLAKHENIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSISTSSFSGSTRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRLLIPSTLVSSPGETPAESGIALEGMKLNTPEMERKNVLDRLKNNAMKGARMGKDFMHRLTATETEEKSAEVYTIESEEATDHEVNLNMASGGQEVAITTSSTQILSEFCGQAKYWFGKDYSNFILKDWMNLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNAMKLEKLRDNTRFPYLMPKSYHQVRLNPNIQQNRQQRVTCQLLRSVSAWSCGFIEADLVEQSIHDAYIQTITKAQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIMPLLPGFEGDVGGSTGIAVRAITHWNYASISRGRTSILTRLQEAGIANPENYISFHSLRNHSFLNNTPITELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMNGKKYPSGVFAGRLRKYLFKEHLGLLESEGSSRSDLDINDPVCEKFWHGTWRRISMQNTEIYDEVFKCIPTDFVKTFASLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEGLIPTSVWT