wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2) (Q62520)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
Subcellular location: Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus.
Interaction partners:
- Homeobox protein SIX3
- Zinc finger protein ZIC 5
- Ephrin type-B receptor 1
- Homeobox protein OTX2
Sequence:
MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPPEQHGPHASQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGAGSGSSGSGGGSAAGSGGGGGGAGGGGGGSSGGGSGTTGGHSGLSSNFNEWYV
Protein: Exocyst subunit Exo70 family protein (Q9C8H6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Exocyst complex component EXO84C
- Exocyst complex component SEC8
- Exocyst complex component SEC6
- Exocyst complex component SEC5A
- Exocyst complex component SEC5B
- Exocyst complex component SEC3B
- Exocyst complex component SEC3A
- Exocyst complex component EXO84A
- Exocyst complex component SEC15B
- Exocyst complex component EXO84B
Sequence:
MAESKRLERLKAMRSLLKSEMEKSETFSLVLNKTGSKIEEINHKLSSLEADLKVERWKASPFSDHIRHTIAPISAVLRVFATVQELERSLVSSDGVLGYVSDVKRLGEAMKLLSSSCVLALNWLEDTIEYLTEKGMPEDHPCGLRFKTSIELLRELQMTESRAYLKGGILYTALKNLETEFKRILQEKPVFSEDNLRKLQAIIKRLHAHTRLTSCVPVYIKVRTKVIQKRFEISYLEKTITEADNVHDIEGDIDQWRLHMEIAVKEIYEFESKLCYDVFEDIGEDVPLRCFGEIASNSVILQLLRFGSRISKCKREPPKLIKLLDCFSTMDNFRIEFNRLFRGEQCSEIRRVTRELISNLVKGVSEIFWELPCQVELQRPNCPPLDGGVPKLVSVVTEYCNKLLGNNNKPILSKVLEIDLGWKNAKYQEELLTGHIYNILREIALNLDAWSSSNKETALSCIFMMNNHSHFCGLRETYLGEMMGESWLNAHEQYRDYYAALYVKESWGHLLSLLTNKAQTTSSSSSSSSESSPVKGKRARESIKRTLQAFCKGFDEIYTKQSNWVVEDDKLVWKICQAMVKTVVPRYKSYLQSYIKLLVEEDPTSDSKHLYYTPKGLEMKLKTMFQKKEETEKRDKDSHFVNKVMDLEITQNSRSTLEAI
Protein: Btbd2 protein (Q6IS59)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
HASALMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT
Protein: CUGBP Elav-like family member 2 (A0A0J9YXJ0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTSAFKLDFLPDMMVEGRLLVPDRINGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATSTNANPLSTTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGTINTPRSKRLLLPKDNNGMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY
Protein: Breakpoint cluster region protein (EC 2.7.11.1) (Q6PAJ1)
Organism: Mus musculus (Mouse)
Function: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity (By similarity). Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity. Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (By similarity).
Subcellular location: Postsynaptic density {ECO:0000269|PubMed:25331951}. Cell projection, dendritic spine {ECO:0000269|PubMed:20962234}. Cell projection, axon {ECO:0000269|PubMed:20962234}. Synapse {ECO:0000250|UniProtKB:F1LXF1}.
Interaction partners:
- Growth factor receptor-bound protein 2
- Tyrosine-protein kinase ABL1
- Crk-like protein
- Adapter molecule crk
- Signal transducer and activator of transcription
- E3 ubiquitin-protein ligase CBL
- SHC-transforming protein 1
- Signal transducer and activator of transcription 5B
- SHC-transforming protein 3
- SHC-transforming protein 2
Sequence:
MVDSVGFAEAWRAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQPPDGAAEPRASAPRPPPAPADGADPAPVEESEARPDGEGSPSKGRSASARRPAAAASADRDDRGPPTSVAALRSNFEKIRKGPAQPGSADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQQSAGQGLGEAPRPHYRGRSSESSCGLDGDYEDAELNPRFLKDNLINANGGNRPPWPPLEYQPYQSIYVGGMMVEGEGKSPLLRSQSTSEQEKRLTWPRRSYSPRSFEDSGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCQKRHRQCQVVVSEATIVGVRKTGQIWPSDGDSTFQGEADSSFGTPPGYGCAADQAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSLASGALDPTKVSELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMETAEKCCQANAQFAEISENLRARSNKDVKDSTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPSSHPDHSLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHIFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEALPNIPLVPDEELDALKIKISQIKSDIQREKRANKGSKVMERLRKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRESIREQQKKCFKSFSLTSVELQMLTNSCVKLQTVHHIPLTINKEDDESPGLYGFLHVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTTEPNWNEEFEIELEGSQTLRILCYEKCYNKMKMTKEDGESADKLMGKGQVQLDPQTLQDRDWQRTVIDMNGIEVKLSVKFTSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKETVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV
Protein: NAC domain-containing protein 55 (ANAC055) (NAC domain-containing protein 3) (AtNAC3) (Q9LDY8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factors that bind specifically to the 5'-CATGTG-3' motif.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc-finger homeodomain protein 11
- Chaperone protein ClpD, chloroplastic
- Transcription factor MYC2
- Salicylate/benzoate carboxyl methyltransferase
- ABSCISIC ACID-INSENSITIVE 5-like protein 7
- Vegetative storage protein 1
- ABSCISIC ACID-INSENSITIVE 5-like protein 5
- Dehydration-responsive element-binding protein 2A
- Basic leucine zipper 8
- ATMYB2
Sequence:
MGLQELDPLAQLSLPPGFRFYPTDEELMVEYLCRKAAGHDFSLQLIAEIDLYKFDPWVLPSKALFGEKEWYFFSPRDRKYPNGSRPNRVAGSGYWKATGTDKVISTEGRRVGIKKALVFYIGKAPKGTKTNWIMHEYRLIEPSRRNGSTKLDDWVLCRIYKKQTSAQKQAYNNLMTSGREYSNNGSSTSSSSHQYDDVLESLHEIDNRSLGFAAGSSNALPHSHRPVLTNHKTGFQGLAREPSFDWANLIGQNSVPELGLSHNVPSIRYGDGGTQQQTEGIPRFNNNSDVSANQGFSVDPVNGFGYSGQQSSGFGFI
Protein: Conserved protein (O86353)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable alanine rich hydrolase
- Probable transmembrane protein FxsA
Sequence:
MTTIEIDAPAGPIDALLGLPPGQGPWPGVVVVHDAVGYVPDNKLISERIARAGYVVLTPNMYARGGRARCITRVFRELLTKRGRALDDILAARDHLLAMPECSGRVGIVGFCMGGQFALVLSPRGFGATAPFYGTPLPRHLSETLNGACPIVASFGTRDPLGIGAANRLRKVTAAKNIPADIKSYPGAGHSFANKLPGQPLVRIAGFGYNEAATEDAWRRVFEFFGQHLRAGSPGEP
Protein: Toll-like receptor 9 (CD antigen CD289) (Q9EQU3)
Organism: Mus musculus (Mouse)
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305481, ECO:0000269|PubMed:31408613}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305481}. Endosome {ECO:0000269|PubMed:18305481, ECO:0000269|PubMed:25917084}. Lysosome {ECO:0000269|PubMed:18305481, ECO:0000269|PubMed:18820679, ECO:0000269|PubMed:25917084}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:18305481, ECO:0000269|PubMed:18820679}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (PubMed:18305481). Exit from the ER requires UNC93B1 (PubMed:18820679). Endolysosomal localization is required for proteolytic cleavage and subsequent activation (PubMed:18820679, PubMed:18931679). Intracellular localization of the active receptor may prevent from responding to self nucleic acid (PubMed:18820679). {ECO:0000269|PubMed:18305481, ECO:0000269|PubMed:18820679, ECO:0000269|PubMed:18931679}.
Interaction partners:
- Myeloid differentiation primary response protein MyD88
- High mobility group protein B1
- Toll-like receptor 7
- Toll/interleukin-1 receptor domain-containing adapter protein
- TIR domain-containing adapter molecule 2
- Toll-like receptor 4
- Toll-like receptor 2
- Interleukin-1 beta
- TIR domain-containing adapter molecule 1
- Protein unc-93 homolog B1
Sequence:
MVLRRRTLHPLSLLVQAAVLAETLALGTLPAFLPCELKPHGLVDCNWLFLKSVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFSCHMTIEPRTFLAMRTLEELNLSYNGITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSNLTHLSLKYNNLTKVPRQLPPSLEYLLVSYNLIVKLGPEDLANLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVNLSVLDLSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMNGIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRISGPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLTVLDVRSNPLHCACGAAFVDLLLEVQTKVPGLANGVKCGSPGQLQGRSIFAQDLRLCLDEVLSWDCFGLSLLAVAVGMVVPILHHLCGWDVWYCFHLCLAWLPLLARSRRSAQTLPYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVLAHTDRVSGLLRTSFLLAQQRLLEDRKDVVVLVILRPDAHRSRYVRLRQRLCRQSVLFWPQQPNGQGGFWAQLSTALTRDNRHFYNQNFCRGPTAE
Protein: Cyclin-dependent kinase inhibitor Dacapo (P91668)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVSARVLNPVMISEFCKMSSSPAVSRNLACGRQLNRIKRDLFGSSKSAEGTANKTPFNSELERHQELATQKWGFDFRAGCPLAEKSPYIWERVSFQESTFAPEMYTLTRAAHVRPSADASPSDMDILVNERSERENFGSNLVNSSLESNTDNESCYDSQDESLAMRLSSSSTTSTSSIVLRKRQPKITEFMKERKRLAQAPKKLSPAKRMRTSSPSSSATSSSSSSGGFGLGAHFGAMLKRPRHN
Protein: Acyl-CoA dehydrogenase FadE29 (ACAD) (EC 1.3.99.-) (3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA dehydrogenase beta subunit) (3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase beta subunit) (P71858)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the third cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. Contributes partly to the virulence by increasing the efficiency of beta-oxidation. Catalyzes the dehydrogenation of 2'-propanoyl-CoA ester side chains of 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) to yield 3-oxo-4,17-pregnadiene-20-carboxyl-CoA (3-OPDC-CoA). Also able to dehydrogenate steroyl-CoA such as 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA), 1beta-(2'-propanoyl-CoA)-3a-alpha-H- 7a-beta-methylhexahydro-4-indanone (indanone-CoA ester), hexahydroindanone and pregenenone.
Interaction partners:
- Acyl-CoA dehydrogenase FadE28
- 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase beta subunit
- 17-hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA lyase
- Steroid 3-ketoacyl-CoA thiolase
- 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase alpha subunit
- Steroid C26-monooxygenase-3-oxocholest-4-en-26-oate forming])
- Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4
- Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3
- (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA hydrolase (HIEC-CoA hydrolase)
- Probable acyl-CoA dehydrogenase FadE32
Sequence:
MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRHGPAYRAVIRRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVPLPAVTLQTVGPTLQAHGSELQKKKFLPAILAGEAHFAIGYTEPEAGTDLASLRTTAVRDGDHYIVNGQKVFTTGAHDADYIWLACRTDPNAAKHKGISILIVDTKDPGYSWTPIILADGAHHTNATYYNDVRVPVDMLVGKENDGWRLITTQLNNERVMLGPAGRFASIYDRVHAWASVPGGNGVTPIDHDDVKRALGEIRAIWRINELLNWQVASAGEDINMADAAATKVFGTERVQRAGRLAEEIVGKYGNPAEPDTAELLRWLDAQTKRNLVITFGGGVNEVMREMIAASGLKVPRVPR
Protein: STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) (Q9CWR7)
Organism: Mus musculus (Mouse)
Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:16609065}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:16609065}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Metalloreductase STEAP2
- Prostate stem cell antigen
Sequence:
MEISDDVTNPEQLWKMKPKGNLEDDSYSTKDSGETSMLKRPGLSHLQHAVHVDAFDCPSELQHTQEFFPNWRLPVKVAAIISSLTFLYTLLREIIYPLVTSREQYFYKIPILVINKVLPMVAITLLALVYLPGELAAVVQLRNGTKYKKFPPWLDRWMLARKQFGLLSFFFAVLHAVYSLSYPMRRSYRYKLLNWAYKQVQQNKEDAWVEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTVHALVFAWNKWVDVSQFVWYMPPTFMIAVFLPTLVLICKIALCLPCLRKKILKIRCGWEDVSKINRTEMASRL
Protein: Protostome-specific GEF, isoform B (RE74757p) (Q29R48)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPTMTRMHRHSSSSAVVEESRGRRRGVGVPGVGDANKENFGVHFMSSPFGNASLIALQDLSNVHGKSPQRRSFSEGSGPRQATPQLAALRCLPRTTGGAVALEDSQLSSSRMGDTTLDRMLDAIIESARKEVRCTKTLPGAGATTSTTILADNAEWSETSVHEMEVRTPTHLKRQRVVRRKNPHKTTTINQTQSHQAKKLEPLQLVPSTKRCLSFSSSSASSDLDEDEQQVAKRSSLASPTTTPPSHCTTTTSSISSSSSSNGGADMEASQRGSIDVSIAFDAKEQQLNVHVIRCRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGSMSSGYQRTAVHRHSGRPYFDQRFNFQISSGEETAGQYLQLAVWHRDRHLKRSEFLGCSTFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISIDSMGKEDPLLPQQPQQPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQATGSQSSASKANESNANHLNNGTSGGRRQSTMPNSGGSSVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWTHPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIFRRSGAGATTITSTDLGQNNVHISTRLGAAVGLGSEEHTLATTATGTTTVMSLQRTTSTRIQPLANSMSRPATACSGTTSSIEAAKRRLHLPQVTFSKEVGKGVFV
Protein: Large ribosomal subunit protein bL34m (39S ribosomal protein L34, mitochondrial) (L34mt) (MRP-L34) (A8NN94)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279069, ECO:0000269|PubMed:16510155}.
Interaction partners:
- Large ribosomal subunit protein mL46
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein uL29m
- MRPL41 protein
- Ribosomal protein
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein bL19m
Sequence:
MAFSVGSVGCLLGPVSRSAGLLGGRWLQGSRAWLGLPDTRRLPVIQQTRGRTRGNEYQPSNIKRKNKHGWIRRLSTPNGVQVILRRMHKGRKSLSH
Protein: SD04694p (Q95TH3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAGNPDYLINLIDSPGHVDFSSEVSTAVRLCDGAIVVVDVVEGVGPQTRACLRQIYEEQLKPVLVLNKLDRLILEKQMDPLDAYFHLCQVLEQVNAVLGSIFASDILAKEDITKKDNYESALEEVDDSELYFSPSSGNVIFCSAYDGWAFSVRDFAAMYAKRLEMSRKDLENVLWGDFYYNSKKKEALPGAQEKAKKPMFVQFVLENIWSLYDIIAIRKDKDKLPGIAEKLGLKLATRDLRLTDPKLQIKAVLGQWLPIDKSVLHMVIQHVPPPHKISDERAQRLLYPANVDLSSLPPETLELKESFTSCDANSSNVIAFVSKMTPVHITHLPQNRPKRLTDQEVQQRRDEVRRRIEERKQQSEQAELEKISQGVEQLSTQVVGPEKEESKPEEADQNEFVFIAFARVFSGTLKRGMELFNLSPKHDPRQPTHRKEGEAPYASRVTIGDLYMFMGGELQLLDEVPAGNIVGIGGLESHIVKTATLSSSLDCTSFSELSVMATPILRVAIEPVQPQDMPKLVKGLKLLNQADACVQVSVAPTGEHVITTLGEVHVEKCVHDLEQSYAKIKVNVSKPIVSFRETIVPAATVDMVNEAIVKTAEDKDVSKKIAVQQTLNKLGTLKVIAVPLPAEAVELLETHSEFFKELAAIPRNQLLSEKWTALLASIKVKLIAALKDLQLFGLSTLSPEELVNRIWALGPRNCGTNILLNLSDYEQPDFWSSHAKSDTDIRSKTDPRKDFNSSLVNGFQITSVAGPLCEEPMQGVCFAVLEWSIQSEGEDLNSRGPFSGQVLTAAKEVCRQAFQNQPQRLVTPMYSCNIVVNAEMLGKMYAVIGRRHGKILSGDLTQGSGNFAVTCLLPVIESFNFAQEMRKQTSGLACPQLMFSHWEVIDIDPFWLPTTEEELMHFGEKADSANRAKVYMDSVRRRKGLFVDEQVVEHAEKQRTLSKNK
Protein: Syntaxin-6 (G3H7H9)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Interaction partners:
- Syntaxin-16
- Vesicle transport through interaction with t-SNAREs homolog 1A isoform X2
- Vesicle-associated membrane protein 4
- Vesicle-associated membrane protein 8
- Synaptobrevin homolog YKT6
- Vacuolar protein sorting-associated protein 51 homolog
- Vacuolar protein sorting-associated protein 45
- Syntaxin-5
- Synaptosomal-associated protein 29
- Syntaxin-12
Sequence:
MCDLSFLSLHLDYREVQKAVNTAQGLFQRWTELLQGPSAATREEIDWTTNELRNNLRSIEWDLEDLDETINILFSLWFEANPRKFNLDATELSIRKAFITSTRQIVRDMKDQMSASSVQALTERKNRQALLGDSSSQNWNTGVTDRYGRLDRELQLANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLDDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLILFLVL
Protein: Linear element protein rec27 (Meiotic recombination protein rec27) (Meiotically up-regulated gene 41 protein) (Q9USR4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: During meiotic DNA recombination, binds to and activates DNA double-strand break (DSB) hotspot sites.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:23395004, ECO:0000269|PubMed:33825974}. Chromosome {ECO:0000269|PubMed:23395004}. Note=Localizes to chromosomal double-strand break (DSB) hotspot sites during the meiotic cell cycle. {ECO:0000269|PubMed:23395004}.
Interaction partners:
- Linear element protein rec25
- Linear element protein rec10
- Linear element protein Mug20
- Linear element-associated protein hop1
- Meiotic recombination protein rec12
- Meiotic recombination protein rec11
- Meiotic recombination protein rec24
- Meiotic recombination protein rec15
- Meiotic recombination protein rec8
- Mei4-dependent protein 2
Sequence:
MKKRSETLGSDQSSSEIIEHVLEELNLKNIERRVKKYDQIESEYKTNIENEKKAFIKDVSQVQQKIKEFEIQKANQIKQLNEEKLSIEARKQQLEIEIRNQLLQYAEKLRIVVKTPMNQPTNTEV
Protein: Biogenesis of lysosome-related organelles complex-1 subunit 2 (BLOC-1 subunit 2) (Spinal cord-expressed protein 1) (Q32WR5)
Organism: Rattus norvegicus (Rat)
Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6QNY1}. Lysosome membrane {ECO:0000250|UniProtKB:Q6QNY1}. Note=Localizes to the centrosomes in a microtubule-dependent manner. {ECO:0000250|UniProtKB:Q6QNY1}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- SNARE-associated protein Snapin
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Dysbindin
- BLOC-1 related complex subunit 8
- KxDL motif-containing protein 1
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Biogenesis of lysosomal organelles complex 1 subunit 4
- BLOC-1-related complex subunit 7
Sequence:
MAAAAEGVPATRREEPPRDDAAVETAEEAKEPAEADINELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR
Protein: Fast muscle troponin I (Troponin I type 2a (skeletal, fast), tandem duplicate 4) (Troponin I, skeletal, fast 2a.4) (Q0D2W2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Troponin C, skeletal muscle
- Troponin T type 1
- Fast skeletal muscle troponin T
- Troponin C, slow skeletal and cardiac muscles
- Si:rp71-17i16.4.
- Slow troponin T
- Tropomyosin 2
- Tnnt3b protein)
- Myosin, light chain 1, alkali; skeletal, fast
- Troponin T type 2a
Sequence:
MSEKKMTSSRRHHLKSLVLSIAFNLLDAEAKQHIADKESHMSENCPALDLPGSVQELQDLCKKLHQQIDKVDEERYDMEAKVAKADKEIEDLKIKVIDLKGKFKKPALKKVRMSADAMLQALLGSKHKVSMDLRANLKQVKKEVKEESVEQVGDWRKNIEDKAGMDGRKKMFESEA