Protein: Dystrophin, isoforms A/C/F/G/H (DmDYS) (Protein detached) (Q9VDW6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. Both det and Dg are required for maintenance of early dpp signaling in the presumptive crossvein. Isoform A is not required to maintain muscle integrity, but plays a role in neuromuscular homeostasis by regulating neurotransmitter release. May play a role in anchoring the cytoskeleton to the plasma membrane.
Subcellular location: Cell membrane, sarcolemma {ECO:0000269|PubMed:16399704}; Peripheral membrane protein {ECO:0000269|PubMed:16399704}; Cytoplasmic side {ECO:0000269|PubMed:16399704}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16399704}. Note=Isoform A is localized to both the postsynaptic region of the NMJ and to the extrasynaptic regions, where it colocalizes with actin.
Interaction partners:
- Dystroglycan 1
- Dystrobrevin, isoform F
- IP02644p
- FI16515p1
- Sarcoglycan alpha, isoform C
- EG:4F1.1 protein
- Alpha-actinin, sarcomeric
- Beta-sarcoglycan
- GH23568p
Sequence:
MEPGILIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNLKPEKGRMRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKSLLAWARQYTEPHGLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQHALKRLHLAFDLAHRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVLTLLLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLSALGERWSHVVKWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQQRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIENLNHFAAEYNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIKEAEPAQKESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNERGGELLLQMDELQDQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLEHISTQLGEFKKFMVSETGYLDKLENKIRNTPENAADAEEIMEELDDLENVLRSHSEEWLDKIQEIGNELIDNEFMADSIRRDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSEKCIVQFEKWLTRVDDILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISELIDEHTRNGKVGAANRLQEQLNLMEVRFKYCQAKLSKCTAIQHSYESRLNRAYTDLRNVERSTEVVDVASAGPNTVQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQSKATLERLLTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQSCMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINVPSNPEIEKLQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDDTEIVVVSDTVRQRRARTPQSGESPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDLLRPSAENTSTPFLRVEKRRISFDEKRKRVANERDILRDSEEEEPKTPDTPRAAQVSKPKRWRQLQPEMDALEPESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFSLEMTSTIDSDSDTSRIMTPSTKNPNPFLSKVLESLSSPVDDSNVTLKSPISEEQPQNLDDRVREFDKQAKQMIYKLKLTKAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIILREQFREVQQARSKTSGSGAPAPPLDSVNIEELVTKGLRRINVLIEKTVDLKSSTDLEKRMEDINERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIAHADSIELSLTELRNGPRISNGKERPDASSAATMSCRSEYNNEPSGTGALAGSFDKSVLQISDWLTWEQNMIKIQSVLVDDGDAVRLAIEKQEKVLRELKMKKPQLNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHCSADLDYMRCCLKVTRLREHWDETSQCVLQRAAQLKNMLSDSQRFEAKRLELEKWLARMEQRAERMGTIATTADILEAQQKEQKSFHAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIKKMTEVINQRYANLNSGVINRGKQLHAAVHSLQSFDRAMDQFLAFLSETETLCENAESDIERNPLMFKDLQSEIETHRVVYDRLDGTGRKLLGSLTSQEDAVMLQRRLDEMNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTEWVIRKDTELSTLGLGPVRGDAVSLQKQLDDHKAFRRQLEDKRPIVESNLTSGRQYIANEAAVSDTSDTEANHDSDSRYMSAEEQSRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTKMRQFQKILEDLSSRVALAEQTKTSWLPPSSVGEANEQMQQLQRLRDKMTTASALLDDCNEQQSFFTANQVLVPTPCLSKLEDLNTRMKLLQIAMDERQKVLCQAGAQQTHENGDDGRTTSNSGTIGPLPNLGQSVKPPWERATTAANVPYYIDHERETTHWDHPEMIELMKGLADLNEIRFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLYVTIDKIDLTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLVADTDRRADQRRLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCLEQAGISQEAIDGNQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKCFNFDMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNKFKSRKYFKKHPRVGYLPVQSVLEGDALESPAPSPQHTTHQLQNDMHSRLEMYASRLAQVEYGGTGSNSTPDSDDEHQLIAQYCQALPGTSNGSAPKSPVQVMAAMDAEQREELEAIIRDLEEENANLQAEYQQLCSKEQSGMPEDSNGMQHSSSSMTGLSGQGEQGQDMMAEAKLLRQHKGRLEARMQILEDHNRQLEAQLQRLRQLLDEPNGGGSSATSSGLPSAPGSALNSKPNTLQTRSVTASQLNTDSPAKMNQQNGHYEHNSKGIMLPGMNSEIQQQHAQLASLAAKHHQHQLSGALNALHQQQQQQLQQQPPQQQRSMMTGNGGMDISGGMQTSGGYLGDDGRPPPPPHSSLMQQQHQQHLNENSSGLVTVITEQELESINDDLEDSSSSNTTNTTTTTTTTATTEKTCVELQK