wanglab/gogpt-training-data huggingface dataset:
Protein: Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (3-demethylubiquinone 3-O-methyltransferase) (EC 2.1.1.-) (EMBRYO DEFECTIVE 3002) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114) (O49354)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03190, ECO:0000305|PubMed:25732537}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03190}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03190}.
Interaction partners:
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Protein ABC transporter 1, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- FAD/NAD
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- Ubiquinone biosynthesis protein
- AT5g10730/MAJ23_90
- Polyketide cyclase / dehydrase and lipid transport protein
- NAD
Sequence:
MLASVRVNQLQRLLLSARRLSSSPIIPPSRLLHQRLFSTSDTDASAASFSSSHPKIQTLEGKASNKSRSTSSTTSLNEDELAKFSAIADTWWHSEGPFKPLHQMNPTRLAFIRSTLCRHFSKDPSSAKPFEGLKFIDIGCGGGLLSEPLARMGATVTGVDAVDKNVKIARLHADMDPVTSTIEYLCTTAEKLADEGRKFDAVLSLEVIEHVANPAEFCKSLSALTIPNGATVLSTINRTMRAYASTIVGAEYILRWLPKGTHQWSSFVTPEEMSMILQRASVDVKEIAGFVYNPITGRWLLSDDISVNYIAYGTKRKDLGDI
Protein: Vibriobactin synthesis protein, putative (Q9KTV9)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Interaction partners:
- Vibriobactin-specific 2,3-dihydroxybenzoate-AMP ligase
- Vibriobactin-specific isochorismatase
- Enterobactin synthetase component F-related protein
- Acyl carrier protein, putative
- Acyl carrier protein
- Enterobactin synthase component D
- Vibriobactin-specific isochorismate synthase
- Isochorismate synthase MenF
- RfbL protein
- Long-chain-fatty-acid--CoA ligase
Sequence:
MSMLLAQKPFWQRHLAYPHINLDTVAHSLRLTGPLDTTLLLRALHLTVSEIDLFRARFSAQGELYWHPFSPPIDYQDLSIHLEAEPLAWRQIEQDLQRSSTLIDAPITSHQVYRLSHSEHLIYTRAHHIVLDGYGMMLFEQRLSQHYQSLLSGQTPTAAFKPYQSYLEEEAAYLTSHRYWQDKQFWQGYLREAPDLTLTSATYDPQLSHAVSLSYTLNSQLNHLLLKLANANQIGWPDALVALCALYLESAEPDAPWLWLPFMNRWGSVAANVPGLMVNSLPLLRLSAQQTSLGNYLKQSGQAIRSLYLHGRYRIEQIEQDQGLNAEQSYFMSPFINILPFESPHFADCQTELKVLASGSAEGINFTFRGSPQHELCLDITADLASYPQSHWQSHCERFPRFFEQLLARFQQVEQDVARLLAEPAALAATTSTRAIAS
Protein: Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (P0C2H4)
Organism: Bos taurus (Bovine)
Function: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:16505484}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UL01}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9UL01}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UL01}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9UL01}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UL01}. Microsome membrane {ECO:0000269|PubMed:16505484}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UL01}.
Interaction partners:
Sequence:
MRTHTRGAPSVFFICLFCFVSACVTDENPEVMIPFTNANYDSHPMLYFSRAEVAELQLRAASSHEHIAARLTEAVNTMLSSPLEYLPPWDPKEYSARWNEIYGNNLGALAMFCVLYPENMEARDMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQQEKFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLVLMNQGYLQEAYLWTKQVLTIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLVQRHFDINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPESQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLWYDASLKSVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALYGPKYTFFNNVLMFSPAASKSCFSPWEGQVTEDCSSKWSKYKHDPAASCQGRVVAAVEKNGVVFIRGEGVGAYNPQLHLRNVQRNLILLHPQLLLLVDQIHLGEDSPLERAASFFHNVDFPFEETVVDGVHGALIRQRDGLYKMYWMDDTGYSEKGTFASVTYPRGYPYNGTNYVNVTTHLRSPVTRAAYLFIGPSIDVQSFSIHGDAQQLDVFVATSEHAYATYLWTGETAGQSAFAQVIADRQKILFDRSSAIRSSVVPEVKDYAALVEQNLQHFKPVFQLLEKQILSRVRNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQQQQQQQSKSKKNRRGGKRYKFVDAVPDIFAQIEVNERKVRQKAQILAQKELPVDEDEEMKDLLDFADITYEKHKNGDVMNGRFGQARMVTTHSRAPALSASYTRLFLILNIAIFFVMLAMQLTYFQRAQSLHGQRCLYAVLLIDSCILLWLYSSCSQSQC
Protein: Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] (P31335)
Organism: Gallus gallus (Chicken)
Function: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54113}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Amidophosphoribosyltransferase
- Multifunctional protein ADE2
- Trifunctional purine biosynthetic protein adenosine-3
- Adenylosuccinate lyase
- Adenylosuccinate synthetase isozyme 2
- Uncharacterized protein.
- Adenylosuccinate synthetase isozyme 1
- Uncharacterized protein.
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
Sequence:
MAARQQLALLSVSEKAGLVEFARSLNALGLGLIASGGTATALRDAGLPVRDVSDLTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMNKQDFSLVRVVVCNLYPFVKTVSSPGVTVPEAVEKIDIGGVALLRAAAKNHARVTVVCDPADYSSVAKEMAASKDKDTSVETRRHLALKAFTHTAQYDAAISDYFRKEYSKGVSQLPLRYGMNPHQSPAQLYTTRPKLPLTVVNGSPGFINLCDALNAWQLVKELKQALGIPAAASFKHVSPAGAAVGIPLSEEEAQVCMVHDLHKTLTPLASAYARSRGADRMSSFGDFIALSDICDVPTAKIISREVSDGVVAPGYEEEALKILSKKKNGGYCVLQMDPNYEPDDNEIRTLYGLQLMQKRNNAVIDRSLFKNIVTKNKTLPESAVRDLIVASIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEDEDLVKWQAMFEEVPAQLTEAEKKQWIAKLTAVSLSSDAFFPFRDNVDRAKRIGVQFIVAPSGSAADEVVIEACNELGITLIHTNLRLFHH
Protein: WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) (O75554)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:28781166}. Nucleus speckle {ECO:0000255|PROSITE-ProRule:PRU00130, ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:9724750}.
Interaction partners:
- Small nuclear ribonucleoprotein-associated proteins B and B'
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- U4/U6 small nuclear ribonucleoprotein Prp31
- U2 small nuclear ribonucleoprotein B''
- Zinc finger matrin-type protein 2
- Microfibrillar-associated protein 1
- U4/U6.U5 tri-snRNP-associated protein 1
- Pre-mRNA-splicing factor 38A
- U6 snRNA-associated Sm-like protein LSm6
- U4/U6 small nuclear ribonucleoprotein Prp4
Sequence:
MADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVAKRISEIKQKSLDKAKEEEKASKEFAAMEAAALKAYQEDLKRLGLESEILEPSITPVTSTIPPTSTSNQQKEKKEKKKRKKDPSKGRWVEGITSEGYHYYYDLISGASQWEKPEGFQGDLKKTAVKTVWVEGLSEDGFTYYYNTETGESRWEKPDDFIPHTSDLPSSKVNENSLGTLDESKSSDSHSDSDGEQEAEEGGVSTETEKPKIKFKEKNKNSDGGSDPETQKEKSIQKQNSLGSNEEKSKTLKKSNPYGEWQEIKQEVESHEEVDLELPSTENEYVSTSEADGGGEPKVVFKEKTVTSLGVMADGVAPVFKKRRTENGKSRNLRQRGDDQ
Protein: E3 ubiquitin ligase rnf-121 (EC 2.3.2.27) (RING finger protein 121) (Q09251)
Organism: Caenorhabditis elegans
Function: E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates such as the beta-integrin subunit pat-3, promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Negatively regulates the unfolded protein response to reduce endoplasmic reticulum stress. Required for the cessation of distal tip cell migration at the end of larval morphogenesis. Plays a role in germline and gonad development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20357004}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:20357004}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Nuclear speckle splicing regulatory protein 1 homolog
- E3 ubiquitin ligase rnf-5
- RING-type E3 ubiquitin transferase
- E3 ubiquitin-protein ligase hrd-like protein 1
- Zinc finger BED domain-containing protein 39
- Integrin beta pat-3
Sequence:
MGQHGAIRLQNEVQEGMPPPHELTEEEQWAEEHRKMHEKHKGHEAMHMEMMVIFMISVIVGQIFLVTWKRKHFKSYQMCTLIGMLTIPVYVCFNRSWYRFLATWLVFCIFSAFIWLKASAQHISGGTPRFVYKWFLFLHKLSYVLGVVGYLIMMGALLGFHVLFGVSQPTLMDAGILFMFYGVYYGVLGRDFAHICTARMASRIGYYTPEGLPKKHLEDGVCAVCGGRLDDSEHVHDADAVVTTKMVEDEDEKLYKLSCGHVFHEFCIRGWVVVGKLQTCPYCKERVDLQRMFKNPWEKPHLFYGKLLDWIRYLVCWQPLIVTAVQGLTTWMGLE
Protein: LIM domain kinase 1 (EC 2.7.11.1) (Q0PWB7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRLMLLCCTWKDERMGEEEAGVGLPVCSGCGQQIYDDQYLQALSSDWHTLCCRCCECGSSLSHWYYEKDGRLFCKKDYWAKFGELCHGCSEPISTGLIMVAGEQKYHPECFSCLSCGAFIGDGDTYALVERSKLYSGHCYYRSIVTPVSLPDSPCSRIPHTVTLVSIPASTDGKRGFSVSIDQASSPNGYSPEHKRTVRVSQVYPDCISPDVKNSIHVGDRILEINGTPIQNVPLDEIDLLIQETSRLLQLTIEHDPHDQGPSVDHVDGGPSPSGGPSPITRPPSQDISNLRSRIITRSYSIDKSPSSSSAPSPLSLRKDIGRSESLRGVSNRTHRIFRASDLIHGEVLGTGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLDHPNVLKFIGVLYKDKRLNFIAEYIKGGTLRDIIKNMDSNYPWGQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKSVVVADFGLSRLMVEDRSVERRKADRRKRYTVVGNPYWMAPEMIHGKSYDEKVDLFSFGIMLCEIIGRVNADPDYLPRALDFGLNTAVFLEEHCPADCPAAFFPIAALCCDLDAEKRPAFTKLESWLEDLKMHLELGLHLVSELELLHQDFMQKHTSGGGKNSLHTHPEQPE
Protein: Protein ELYS (G0S2G1)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
Function: Required for the assembly of a functional nuclear pore complex (NPC).
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q8WYP5}.
Interaction partners:
- Nucleoporin NUP152
- Nucleoporin NUP49
- Protein transport protein SEC13
- Nucleoporin NUP133
- Nucleoporin NUP84
- Nucleoporin SEH1
- Nucleoporin NUP170
- Nucleoporin NIC96
- Nucleoporin NUP192
- Nucleoporin NUP145
Sequence:
MLDFTHFPEVFPTDGPRPYDQHFVRQTETFRKSLDGVLFIDRVLGALGLPDAAKAYPPRGDAGLRALHQQVCSAKVSAHAKLSVLYYLLLDHDEHRGSRSQLADALAEEVGLPANYQILMRGLWHMDRKEFKFALEHLAHPSLPAEFADEIITVLVRDGHTTGDYSLPLAYYHAVRPVLQTSSALENLFAALARTSVTDALAFSRTYPDHGARQLLFERLVASVLEEHGSGQVAGRSASRAKELVSLPLTGVEEKWLNDYLSTGEGRKSRSAKAVVQMRQVVTGRQKELGAVVGVRAGR
Protein: Gastric inhibitory polypeptide (GIP) (Glucose-dependent insulinotropic polypeptide) (Incretin hormone) (P09681)
Organism: Homo sapiens (Human)
Function: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
Subcellular location: Secreted.
Interaction partners:
- Gastric inhibitory polypeptide receptor
- Glucagon-like peptide 1 receptor
- Pro-glucagon
- Dipeptidyl peptidase 4
- Glucose-dependent insulinotropic receptor
- Secretin
- Vasoactive intestinal polypeptide receptor 2
- Beta-1 adrenergic receptor
- Lutropin-choriogonadotropic hormone receptor
- Insulin
Sequence:
MVATKTFALLLLSLFLAVGLGEKKEGHFSALPSLPVGSHAKVSSPQPRGPRYAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQREARALELASQANRKEEEAVEPQSSPAKNPSDEDLLRDLLIQELLACLLDQTNLCRLRSR
Protein: P2X purinoceptor (P2X purinoceptor 2) (Q7SZL9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Membrane {ECO:0000256|RuleBase:RU000681}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000681}.
Interaction partners:
Sequence:
MGCLEFLKDFFLGFWDYETPKVMVVKDKKLGVIYRAVQFLVITYFIWYVFISQKAYQETETRPESSVYTEMRGVALLGDAVQDTTECVRPSEGGDVISTILRKEVTHDQTQGTCAEHYSVANANCTRDSDCIQGESDFDGHGQRTGRCIRYYNYTFKTCEIKSWCPIEEYAVVREPALEQAINFTVFIKNAIHFPKFKVLRGNIKPNKPKKLLRCHYHPETNPYCPVFSLGFIAAQAREKFSELCRTGGIIGVFINWKCDFDVDPSACIPTYSFRRLDMRKNLPSSGYYYRFAKYYHKDGVEYRSLIKAYGIRLDVIVHGHAGRFSLIPTIINTVTAMTSVGICSIICDWIMLTFIDKNEVFSEKKFDDVSKQPSQPITTDFTLTSYGSTHSDLSDGVPL
Protein: Pentatricopeptide repeat-containing protein At1g19720 (Protein DYW7) (Q9FXH1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pentatricopeptide repeat-containing protein At1g26460
Sequence:
MEKLFVPSFPKTFLNYQTPAKVENSPELHPKSRKKNLSFTKKKEPNIIPDEQFDYLCRNGSLLEAEKALDSLFQQGSKVKRSTYLKLLESCIDSGSIHLGRILHARFGLFTEPDVFVETKLLSMYAKCGCIADARKVFDSMRERNLFTWSAMIGAYSRENRWREVAKLFRLMMKDGVLPDDFLFPKILQGCANCGDVEAGKVIHSVVIKLGMSSCLRVSNSILAVYAKCGELDFATKFFRRMRERDVIAWNSVLLAYCQNGKHEEAVELVKEMEKEGISPGLVTWNILIGGYNQLGKCDAAMDLMQKMETFGITADVFTWTAMISGLIHNGMRYQALDMFRKMFLAGVVPNAVTIMSAVSACSCLKVINQGSEVHSIAVKMGFIDDVLVGNSLVDMYSKCGKLEDARKVFDSVKNKDVYTWNSMITGYCQAGYCGKAYELFTRMQDANLRPNIITWNTMISGYIKNGDEGEAMDLFQRMEKDGKVQRNTATWNLIIAGYIQNGKKDEALELFRKMQFSRFMPNSVTILSLLPACANLLGAKMVREIHGCVLRRNLDAIHAVKNALTDTYAKSGDIEYSRTIFLGMETKDIITWNSLIGGYVLHGSYGPALALFNQMKTQGITPNRGTLSSIILAHGLMGNVDEGKKVFYSIANDYHIIPALEHCSAMVYLYGRANRLEEALQFIQEMNIQSETPIWESFLTGCRIHGDIDMAIHAAENLFSLEPENTATESIVSQIYALGAKLGRSLEGNKPRRDNLLKKPLGQSWIEVRNLIHTFTTGDQSKLCTDVLYPLVEKMSRLDNRSDQYNGELWIEEEGREETCGIHSEKFAMAFGLISSSGASKTTIRILKNLRMCRDCHDTAKYVSKRYGCDILLEDTRCLHHFKNGDCSCKDYW
Protein: Exocyst subunit Exo70 family protein (F4KGM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAVDSRMDLLSERAVLMRASLQKSQTITDNVVSILGSFDSRLSALETAMRPTQIRTHAIRKAHENIDRTLKAAEVILSQFDLLRQAETKVLKGPHEDLESYLDAIAQLRKIIRYFMSNKSFKSSDGVLNHANSLLAKAQSKLEEEFKQLLASYRILRMTFYLNYRSCHLTKIFFCEIKHFKAVEPDRLFDGLPNSLRPSSDGDGGGKPHGGHHNDDAETAAYTLPILIPSRVLPLLHDLAQQMVQAGHQQQLLQIYRDTRSFVLEESLKKLGVEKLSKEDVQRMQWEVLEAKIGNWIHFMRIAVKLLFAGERQVCDQIFRGFDSLSDQCFAEVTVSSVSMLLSFGDAIARSKRSPEKLFVLLDMYEIMRELHTEIETIFKGKACLEIRDSATGLTKRLAQTAQETFGDFEEAVEKDATKTAVLDGTVHPLTSYVINYVKFLFDYQTTLKQLFLEFGNGDDSNSQLASVTMRIMQALQNNLDGKSKQYKDPALTHLFLMNNIHYMVRSVRRSEAKDLLGDDWVQRHRRIVQQHANQYKRVAWTKILQSSSAQGLTSSGGGSLEGGNSSGVSRGLLKERFKMFNMQFDELHQRQSQWTVPDTELRESLRLAVAEVLLPAYRSFLKRFGPLVESGKNPQKYIKYTAEDLERLLGELFEGKSMNEPRR
Protein: rRNA biogenesis protein RRP5 (AtRrp5) (Ribosomal RNA-processing protein 5) (F4J8K6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biogenesis of ribosomal RNA (rRNA). Required for the formation of 5.8S rRNA. Required for normal development of female gametophytes.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:23382868}.
Interaction partners:
- Protein NUCLEOLAR COMPLEX ASSOCIATED 4
- U3 small nucleolar RNA-associated protein 18 homolog
- AT3g56990/F24I3_70
- At3g57000
- Probable U3 small nucleolar RNA-associated protein 11
- Transducin family protein / WD-40 repeat family protein
- Uncharacterized protein At3g06530
- Protein SLOW WALKER 1
- Nucleolar protein
- ATP-dependent RNA helicase DEAH13
Sequence:
MVVPQKKFANGKRNDSTKSFKPMKKPFKKTKDDVAARSEAMALQLEDVPDFPRGGGTSLSKKEREKLYEEVDAEFDADERVSKKSKGGKSKKRIPSDLDDLGLLFGGGLHGKRPRYANKITTKNISPGMKLLGVVTEVNQKDIVISLPGGLRGLVRASEVSDFTDRGIEDDENELLGDIFSVGQLVPCIVLELDDDKKEAGKRKIWLSLRLSLLHKGFSFDSFQLGMVFSANVKSIEDHGSILHFGLPSITGFIEISDDGNQESGMKTGQLIQGVVTKIDRDRKIVHLSSDPDSVAKCLTKDLSGMSFDLLIPGMMVNARVQSVLENGILFDFLTYFNGTVDLFHLKNPLSNKSWKDEYNQNKTVNARILFIDPSSRAVGLTLSPHVVCNKAPPLHVFSGDIFDEAKVVRIDKSGLLLELPSKPTPTPAYVSTYDAAGDEVTKLEKKFKEGNHIRVRVLGLKQMEGLAVGTLKESAFEGPVFTHSDVKPGMVTKAKVISVDTFGAIVQFSGGLKAMCPLRHMSEFEVTKPRKKFKVGAELVFRVLGCKSKRITVTYKKTLVKSKLPILSSYTDATEGLVTHGWITKIEKHGCFVRFYNGVQGFVPRFELGLEPGSDPDSVFHVGEVVKCRVTSAVHGTQRITLSFMIKPSSVSEDDSIKLGSIVSGIIDTITSQAVIVRVKSKSVVKGTISAEHLADHHEQAKLIMSLLRPGYELDKLLVLDIEGNNMALSSKYSLIKLAEELPSDFNQLQPNSVVHGYVCNLIENGCFVRFLGRLTGFAPRSKAIDDPKADVSESFFVGQSVRANIVDVNQEKSRITLSLKQSSCASVDASFVQEYFLMDEKISDLQSSDITKSDCSWVEKFSIGSLIKGTIQEQNDLGVVVNFDNINNVLGFIPQHHMGGATLVPGSVVNAVVLDISRAERLVDLSLRPELLNNLTKEVSNSSKKKRKRGISKELEVHQRVSAVVEIVKEQHLVLSIPEHGYTIGYASVSDYNTQKLPVKQFSTGQSVVASVKAVQNPLTSGRLLLLLDSVSGTSETSRSKRAKKKSSCEVGSVVHAEITEIKPFELRVNFGNSFRGRIHITEVNDASTSDEPFAKFRVGQSISARVVAKPCHTDIKKTQLWELSVKPAMLKDSSEFNDTQESEQLEFAAGQCVIGYVYKVDKEWVWLAVSRNVTARIFILDTSCKAHELEEFERRFPIGKAVSGYVLTYNKEKKTLRLVQRPLLFIHKSIANGGGSKTDKPDSSIPGDDDTLFIHEGDILGGRISKILPGVGGLRVQLGPYVFGRVHFTEINDSWVPDPLDGFREGQFVKCKVLEISSSSKGTWQIELSLRTSLDGMSSADHLSEDLKNNDNVCKRFERIEDLSPDMGVQGYVKNTMSKGCFIILSRTVEAKVRLSNLCDTFVKEPEKEFPVGKLVTGRVLNVEPLSKRIEVTLKTVNAGGRPKSESYDLKKLHVGDMISGRIRRVEPFGLFIDIDQTGMVGLCHISQLSDDRMENVQARYKAGESVRAKILKLDEEKKRISLGMKSSYLMNGDDDKAQPLSEDNTSMECDPINDPKSEVLAAVDDFGFQETSGGTSLVLAQVESRASIPPLEVDLDDIEETDFDSSQNQEKLLGANKDEKSKRREKQKDKEEREKKIQAAEGRLLEHHAPENADEFEKLVRSSPNSSFVWIKYMAFMLSLADIEKARSIAERALRTINIREEEEKLNIWVAYFNLENEHGNPPEESVKKVFERARQYCDPKKVYLALLGVYERTEQYKLADKLLDEMIKKFKQSCKIWLRKIQSSLKQNEEAIQSVVNRALLCLPRHKHIKFISQTAILEFKCGVADRGRSLFEGVLREYPKRTDLWSVYLDQEIRLGEDDVIRSLFERAISLSLPPKKMKFLFKKFLEYEKSVGDEERVEYVKQRAMEYANSTLA
Protein: Ankyrin 2 (A0A5F9ZI36)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEVTLCEPSILSSTSQFQAEPVEGRRVSKVVKTTVVLGERMEKHLGDSSLATDLPSAKDDFEEDNNE
Protein: D-galactonate dehydratase family member EGBG_01401 (C8ZZN2)
Organism: Enterococcus gallinarum (strain EG2)
Function: Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
Interaction partners:
Sequence:
MTPTIITDVKSFAIKPDRHNLVVVKVETNKGISGLGCSTFQFRPLAVKTVVDEYLRPLLMGRDANEIEDIWQVMNVNSYWRNGPITNNAISGIDMALWDIKGQLADMPLYQLLGGKARTAIPAYTHAVADNLDDLYHEIDRFLAAGYRYIRCQLGFYGGNPSQLQTPEEPISGSYFDQTDYMETTLKMFAAIKEKYGNQFQMLHDVHERLHPNQAIQFAKAAEPYQLFFLEDILPPDQSHWLTQLRSQSATPIATGELFNNPMEWQELVKNRQIDFMRAHVSQIGGITPALKLAHFCDAMGVRIAWHTPSDISPVGLAVNTHLNIHLHNAAIQETIELPANTQSVFVGSPQPKGGFFYPMEKSGIGITFDEEAAADFPVVYRPHEWTQSRTPDGTLITP
Protein: Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) (Q5BKC9)
Organism: Rattus norvegicus (Rat)
Function: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11336673}. Membrane {ECO:0000269|PubMed:11336673}. Cell projection, growth cone {ECO:0000269|PubMed:11336673}. Note=Associated with membranes. Localizes to axonal growth cones.
Interaction partners:
- receptor protein-tyrosine kinase
- Ephrin type-A receptor 1
- Transforming protein RhoA
- Ephrin type-B receptor 1
- Cell division control protein 42 homolog
- receptor protein-tyrosine kinase
- Ephrin type-A receptor 2
- Ephrin type-A receptor 8
- Ephrin type-B receptor 4
- Ephrin type-B receptor 6
Sequence:
METKNSEDQGKPQRKSVSSLWKSKHGPAEMRPELPPETAKETQNEEPRCLIPIQRNSLFNRAMRHKHKARSMSERRANDQAGDLPETRKSVNEPLAFNLPQGRLPPWRTPAQRGPGAQEASESSSTPGNGTTPEECPALTDSPTTLTEALQMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIQGNSDGSQAGEDNAEEEEEEEEEPASPPERRALPQICLLSNPHSRFNLWQDLPEIQSSGVLDILQPEETKLQEAMFELVTSEASYYKSLNLLVSHFMENERLKKILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKTAFRELIAQLELDPKCKGLPLSSFLILPFQRITRLKLLVQNILKRVEEGSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTEDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHKMEDPQRSQNKDRRKLGSRNRQ
Protein: Zinc transporter ZIP9 (ZIP-9) (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (A0A3Q7ZPG5)
Organism: Micropogonias undulatus (Atlantic croaker)
Function: Has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through G protein activation and are required for the androgen-dependent apoptotic response. Upon androgen binding, mediates apoptosis by directly activating a stimulatory G protein that leads to increased cAMP levels and MAP kinase activity and which is accompanied by increased intracellular free zinc levels.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9NUM3}. Cell membrane {ECO:0000250|UniProtKB:Q9NUM3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NUM3}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9NUM3}. Mitochondrion {ECO:0000250|UniProtKB:Q9NUM3}. Nucleus {ECO:0000250|UniProtKB:Q9NUM3}.
Interaction partners:
Sequence:
MDDFSSISLLSVAMLVGCYVAGTIPLAVNFSEEKLKLITVLGAGLLCGTALAVIIPEGVHAIYEEILEGGHHSHGQAGVVEVSEAKGDAESVLSGGGKHEHSHEQLHACIGVSLVLGFVFMLLVDQIGSSHVHSTEDPESARVTSSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVLAMLTFLGLSQSSKEALSDINATGVAMLFSAGTFLYVATVHVLPEVGGGGHSHAASGGNGGKGLSKVEVVALVLGCLIPLVLSVGHHH
Protein: C-C motif chemokine 21 (Chemokine (C-C motif) ligand 25a) (A0A2R8QR67)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- C-C chemokine receptor type 9a
- Chemokine
- Stromal cell-derived factor 1
- Atypical chemokine receptor 4b
- Atypical chemokine receptor 4a
- C-X-C motif chemokine 19 precursor
- Chemokine
- C-C motif chemokine 25
- Stromal cell-derived factor 1
- Interleukin-8
Sequence:
MRFSIFIFIFLLGFIYLTTAQGSYEDCCLKYVRKINHSMKNRVIRYRKQEVDGGCNIPAIVFTLKQGRMFCTDPREKWVHELMQRVDRLKARPYLKRKTSRG