wanglab/gogpt-training-data huggingface dataset:
Protein: Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) (Q96JA1)
Organism: Homo sapiens (Human)
Function: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15282549}; Single-pass type I membrane protein {ECO:0000305|PubMed:15282549}.
Interaction partners:
- Hepatocyte growth factor receptor
- Epidermal growth factor receptor
- E3 ubiquitin-protein ligase CBL
- Receptor tyrosine-protein kinase erbB-2
- Leucine-rich repeats and immunoglobulin-like domains protein 3
- Pro-epidermal growth factor
- Leucine-rich repeats and immunoglobulin-like domains protein 2
- Receptor tyrosine-protein kinase erbB-4
- Homeodomain-only protein
- Proto-oncogene tyrosine-protein kinase receptor Ret
Sequence:
MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLLLAPKS
Protein: ATP-dependent RNA helicase (EC 3.6.4.13) (C6KTE4)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- Ribosome biogenesis protein YTM1, putative
- Nucleolar complex protein 2, putative
- Ribosomal protein L1, putative
- Pescadillo homolog
- Putative rRNA methyltransferase
- Ribosome biogenesis protein BRX1, putative
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Ribosome biogenesis protein MRT4, putative
- Ribosome biogenesis protein NSA2 homolog
Sequence:
MMDDDNDYNTMKNSNDNNLKKTKKNSIIKKKKKKKKKEILENKDSNIDNLKNENYRSESEAESESTNDSVSLNNIEEDNELNENSENNENNENDEDNKNNKNNENNENTSSEEICDHDKNDKTYTDEIKSNNSDHNNNNSKEHFYSELKFEELNICDALKKGLKELNFVTLTEIQAKCIPHFLSGKDILGAAKTGSGKTLAFLVPSINILYNIKFLPKNGTGVLIISPTRELCLQIYQVCKDLCKYIPQTNGIIIGGMSRNEEKKKFIHGINILIATPGRLLDHMQNTKEFIYKNLICLIIDEADRLLQIGFEEEINLIIKRLPKKRQTALFSATQTTKVESLIRLSLQKPIFIEVTTKIATVERLQQGYALVDEDKRFLLLFTFLKKNMSKKIMVFFNNCMSVQFYNDLLNYIDIPTYCIHGKKKQNKRLKSFHDFSAAKCAILLCTNVAARGLDIPNVNYIIQYDPPDDSKEYIHRVGRTCRGQDSNGSAIIFLMKHELKFLNYLKFYNIPINQFAYDPNKLINIQSHIQSIVTKNFHLHKMAREAFKSYLNGYITYALKDVFDVNNLNLLLTSKNFGLEVPPKVDLNLKLNVKKKKFK
Protein: CRISPR system Cascade subunit CasB (P76632)
Organism: Escherichia coli (strain K12)
Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Interaction partners:
- CRISPR system Cascade subunit CasC
- CRISPR system Cascade subunit CasE
- CRISPR system Cascade subunit CasD
- CRISPR system Cascade subunit CasA
- CRISPR-associated endoribonuclease Cas2
- CRISPR-associated endonuclease/helicase Cas3
- CRISPR-associated endonuclease Cas1
Sequence:
MADEIDAMALYRAWQQLDNGSCAQIRRVSEPDELRDIPAFYRLVQPFGWENPRHQQALLRMVFCLSAGKNVIRHQDKKSEQTTGISLGRALANSGRINERRIFQLIRADRTADMVQLRRLLTHAEPVLDWPLMARMLTWWGKRERQQLLEDFVLTTNKNA
Protein: Synuclein alpha interacting protein (D6R9G8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEAPEYLDLDEIDFSDDISYSVTSLKTIPELCRRCDTQNEDRSVSSSSWNCGISTLITNTQKPTGIADVYSKFRPVKRVSPLKHQPETLENNESDDQKNQKVVEYQKGGESDLGPQPQELGPGDGVGGPPGKSSEPSTSLGELEHYDLDMDEILDVPYIKSSQQLASFTKVTSEKRILGLCTTINGLSGKACSTGSSESSSSNMAPFCVLSPVKSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFLNKTFSDPHGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPSSPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDSTAAQKVATSPKSALKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGDQLKRPFGAFRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRKTDAKGNPASSASKGKNKA
Protein: Endoplasmic reticulum protein 44, isoform C (EC 5.3.4.1) (Q9VXI3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTSDNIDMTLASNELVFLNFYAEWCRFSNILAPIFAEAADKIKEEFPEAGKVVLGKVDCDKETAIASRFHINKYPTLKIVRNGQLSKREYRGQRSAEAFLEFVKKQLEDPIQEFKSLKDLENLDSKKRLILGYFDRRDQPEYDIFRKVATNLKEDCQFHVGFGDAAQAMHPPGTPIIVFRPDVALSHENDETYTGSLQNFDELKIWVQEKCVPLVREITFENAEELTEEGLPFLILFHHPTDHNSIKDYKSIIERQLLDEKQNVNFLTADGKRFAHPLHHLGKSEDDLPLIAIDSFKHMYLFPHFSDMYSPGKLKQFLQDLYSGKLHREFHYGPDPSNDIEPDPHTGKGTSPPESKFKELGPSKHRYTLLEKDEL
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) (A8E515)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAAVTLICRPAGVLPKLSGTCSPVLLAAAPVTVQQRKIHHAIVPRGKGGRSSISGLAATVFGATGFLGRYVVNRLGRMGSQVVIPYRCDQYDLMYLRPMGDLGQIIFMEWDPRNKESIQRAISHSNVVINLVGREWETSNYKYEDVFVSIPLQIARATREAGIKKFIHMSHLNADIRSPSKYLRNKAVGEEAVRNEFPDAIIMKPSELFGREDRFLNHFANMRWFGTAVPLIAMGKKTVKQPVHVVDVAKAIINAIQDPEANGKTYALVGPNRYLLHDLVEYLYSVAHRPFMPYPLPRPLYHLVARFFEMNPFEPWTTRDKVDRLHTSDLKYPDLPGLEDLGITPASIEQKAIETLRRHRRQRFFEAAVGEAKPSKTVNF
Protein: Rho-type GTPase-activating protein 2 (Q06407)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GTPase-activating protein (GAP) for CDC42 and/or RHO1.
Interaction partners:
- Cell division control protein 42
- Cell division control protein 24
- Rho-type GTPase-activating protein 1
- Bud emergence protein 1
- Dual specificity protein kinase YAK1
- Serine/threonine-protein kinase CLA4
- Serine/threonine-protein kinase STE20
- Ras-related protein RSR1
- GTP-binding protein RHO1
- GTP-binding protein RHO4
Sequence:
MSADPINDQSSLCVRCNKSIASSQVYELESKKWHDQCFTCYKCDKKLNADSDFLVLDIGTLICYDCSDKCTNCGDKIDDTAIILPSSNEAYCSNCFRCCRCSNRIKNLKYAKTKRGLCCMDCHEKLLRKKQLLLENQTKNSSKEDFPIKLPERSVKRPLSPTRINGKSDVSTNNTAISKNLVSSNEDQQLTPQVLVSQERDESSLNDNNDNDNSKDREETSSHARTVSIDDILNSTLEHDSNSIEEQSLVDNEDYINKMGEDVTYRLLKPQRANRDSIVVKDPRIPNSNSNANRFFSIYDKEETDKDDTDNKENEIIVNTPRNSTDKITSPLNSPMAVQMNEEVEPPHGLALTLSEATKENNKSSQGIQTSTSKSMNHVSPITRTDTVEMKTSTSSSTLRLSDNGSFSRPQTADNLLPHKKVAPSPNKKLSRSFSLKSKNFVHNLKSKTSEMLDPKHPHHSTSIQESDTHSGWGVSSTHTNIRKSKAKKNPVSRGQSDSTIYNTLPQHGNFTVPEFNHKKAQSSLGSISKKQNSNDTATNRRINGSFTSSSSGHHIAMFRTPPLESGPLFKRPSLSSESAHHRSSSLQTSRSTNALLEDDSTKVDATDESATSLEKDFYFTELTLRKLKLDVRELEGTKKKLLQDVENLRLAKERLLNDVDNLTREKDKQSASSRESLEQKENIATSITVKSPSSNSDRKGSISNASPKPRFWKIFSSAKDHQVGDLESQQRSPNSSSGGTTNIAQKEISSPKLIRVHDELPSPGKVPLSPSPKRLDYTPDGSHLYGSSLQARCAYEKSTVPIIIRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLHSDTLSPKLNALLNQDIHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSPQKVTIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSLIHDFDGEKDIVDMKERNYIVEFILGNYRDIFKQA
Protein: Protein Barley B recombinant (Protein BBR) (Q8GUC3)
Organism: Hordeum vulgare (Barley)
Function: Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes. Positively regulates the homeotic gene BKN3.
Subcellular location: Nucleus {ECO:0000269|PubMed:12795701}.
Interaction partners:
Sequence:
MDDDGSLSIRNWGFYETMKGNLGLQLMPSVTGGHRDTKPLLPNGTFLQHHTPPHHPPHSHHPRDYGNGEPSGGMPAEPPAIHMDFVRNEAWMHPSQHQHQHQHQHQHQHQHQHQLQHQHQHQHSRELKVLNAVPVGPAPHIGHPGHAVHHHPTGFGMMPDARGAHTLQMMQPQEPPVPDEEKITPPLVEDHSVVGSKPPVKKRQQGRQPKVPKPKKPKKDATPGEDGAPKARAPRSRGPLKPVEMVINGIDFDISRIPTPVCSCTGAPQQCYRWGAGGWQSACCTTSISTYPLPMNTKRRGARIAGRKMSQGAFKKVLEKLAGEGYNLNNPIDLKTFWAKHGTNKFVTIR
Protein: Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) (P20701)
Organism: Homo sapiens (Human)
Function: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15684041, ECO:0000269|PubMed:16301335}; Single-pass type I membrane protein {ECO:0000255}. Note=Upon antigen recognition by the TCR, is recruited to lipid rafts (PubMed:15684041). {ECO:0000269|PubMed:15684041}.
Interaction partners:
- Intercellular adhesion molecule 3
- Intercellular adhesion molecule 2
- Integrin beta-2
- Intercellular adhesion molecule 1
- Intercellular adhesion molecule 5
- Junctional adhesion molecule A
- Integrin alpha-M
- Vascular cell adhesion protein 1
- Integrin beta-1
- Integrin beta-7
Sequence:
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
Protein: Succinate-semialdehyde dehydrogenase [NADP(+)] 2 (SSA dehydrogenase 2) (SSADH 2) (SSDH 2) (EC 1.2.1.16) (Q9UTM8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- 4-aminobutyrate aminotransferase
- 2-oxoglutarate dehydrogenase, mitochondrial
- Succinate-semialdehyde dehydrogenase [NADP
- Probable citrate synthase, mitochondrial
- Malate dehydrogenase, mitochondrial
- Probable succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Fumarate hydratase, mitochondrial
- Probable ATP-citrate synthase subunit 1
- Probable ATP-citrate synthase subunit 2
Sequence:
MAPQFKRPELFGFDKSHAQSFVQGKWISSPNNKTFEVDNPATGEIIGKVADVSVEETKKAISAANEAFKTYKNFTHVQRSQLLERWAELIMENKDDLVKMLTLENGKPLSQAEMEVTTCSGYLKWYAAEAVRTFGDVAPSSLQSQNFLISIKQPVGVSALITPWNFPAAMIARKGGAALAAGCTAIFLPAFRTPYVCLGLVRLAQEAGFPDGVLNVITSSDASAHGKELTTNPIVRKVSFTGSTNVGKILMGQSASTIKKVSMELGGNAPFIVFPDFPIDQAVESFCTIKFNSCGQVCVCPNRVYVHKNVYDEFVSKLTEKVKTIKVGDGFDSSSAVGPLISQDGCKKVSKHIEDAVSKGAKITVGGKEISSSKGYFFEPTVLSGVTQDMLVASEETFGPLASVFKFDDTEEVIEWANDSDVGLAGYVFTNNLSTMIHVAKELEVGLVGANIEMVDEPFISFGGIKQSGFGKEAGRLGVQEFMVVKEINLKTL
Protein: 3-oxo-5-alpha-steroid 4-dehydrogenase (DUF1295) (F4IAN4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVKVIDSHYLAITAIVTVGYQFIFFVITALFKFDQVTDFAGSTNFVILAVLTLLLKGTWHYRQIVLTVLVVVWGLRLGLFLLMRILQWGEDRRFDDMRENIGKLVVFWIFQAVWVWTVSLPVTFVNASNGGRLFQPADVIGWTMWVAGFLIEATADQQKLSFKKCPENKGKWCDVGVWKYSRHPNYFGEMLLWWGLYVASLPVLKGLEYLVIIGPVFLTLLLLFVSGIPLLEESADKKYGNLGAYRHYKKTTSPLILLPRGVYGYLPIWCKSVFLFEFPLYSRNLPQETTAWDRRNSKKSQRSID
Protein: FGFR2 protein (Q9R294)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
SGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLTVLPKQQAPVREKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKR
Protein: Hepatocyte nuclear factor 4 4 alpha variant 2 (F1D8T1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
Protein: Cecropin-P1 (P14661)
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Function: Has antibacterial activity against several Gram-positive and Gram-negative bacteria. Is weakly active against yeasts. Acts by a nonpore mechanism.
Subcellular location: Secreted {ECO:0000269|PubMed:2512577}.
Interaction partners:
Sequence:
MFLIYLFVQTAESSWLSKTAKKLENSAKKRISEGIAIAIQGGPRRRRFVAEQDAIHSRVSREVPTLSDSV
Protein: Surface protein G (Q2G2B2)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Promotes adhesion of bacterial cells to human squamous nasal epithelial cells, a phenomenon which is likely to be important in nasal colonization. Forms short, extremely dense and thin fibrils all over the bacterial surface. Does not bind to either buccal cells or non-differentiated keratinocytes. Promotes cellular aggregation leading to biofilm formation.
Subcellular location: Secreted, cell wall {ECO:0000255|PROSITE-ProRule:PRU00477, ECO:0000305|PubMed:11830639}; Peptidoglycan-anchor {ECO:0000255|PROSITE-ProRule:PRU00477, ECO:0000305|PubMed:11830639}. Note=Anchored to the cell wall by sortase A. {ECO:0000305|PubMed:11830639}.
Interaction partners:
- Clumping factor A
- Fibronectin-binding protein A
Sequence:
MRDKKGPVNKRVDFLSNKLNKYSIRKFTVGTASILIGSLMYLGTQQEAEAAENNIENPTTLKDNVQSKEVKIEEVTNKDTAPQGVEAKSEVTSNKDTIEHEPSVKAEDISKKEDTPKEVADVAEVQPKSSVTHNAETPKVRKARSVDEGSFDITRDSKNVVESTPITIQGKEHFEGYGSVDIQKKPTDLGVSEVTRFNVGNESNGLIGALQLKNKIDFSKDFNFKVRVANNHQSNTTGADGWGFLFSKGNAEEYLTNGGILGDKGLVNSGGFKIDTGYIYTSSMDKTEKQAGQGYRGYGAFVKNDSSGNSQMVGENIDKSKTNFLNYADNSTNTSDGKFHGQRLNDVILTYVASTGKMRAEYAGKTWETSITDLGLSKNQAYNFLITSSQRWGLNQGINANGWMRTDLKGSEFTFTPEAPKTITELEKKVEEIPFKKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGVIISKGEPKEEITKDPINELTEYGPETIAPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGVIISKGEPKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFKKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFKKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPVNELTEFGGEKIPQGHKDIFDPNLPTDQTEKVPGKPGIKNPDTGKVIEEPVDDVIKHGPKTGTPETKTVEIPFETKREFNPKLQPGEERVKQEGQPGSKTITTPITVNPLTGEKVGEGQPTEEITKQPVDKIVEFGGEKPKDPKGPENPEKPSRPTHPSGPVNPNNPGLSKDRAKPNGPVHSMDKNDKVKKSKIAKESVANQEKKRAELPKTGLESTQKGLIFSSIIGIAGLMLLARRRKN
Protein: Protein SLENDER RICE1-LIKE 2 (OsSLRL2) (Protein SLR1-LIKE 2) (Q6F368)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Its repressive activity is weaker than that of SLR1. Its overexpression prevents the GA signaling pathway and induces a dwarf phenotype in Arabidopsis thaliana plants.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q7G7J6}.
Interaction partners:
- Gibberellin receptor GID1
- F-box protein GID2
- Os07g0143200 protein
- Os04g0618600 protein.
- Helix-loop-helix DNA-binding domain containing protein, expressed
- DELLA protein SLR1
- Transcription factor PHYTOCHROME INTERACTING FACTOR-LIKE 15
- Transcription factor APG
- Os12g0598200 protein
- Transcription factor PHYTOCHROME INTERACTING FACTOR-LIKE 13
Sequence:
MAQFGGFGGWSAMDVAAAAAAALGNVSGAVYHADPAAAVYASLVPGMAVVPGRAPPSAVQIEAARRWKELEKMALRSVNLMVTCAGAIQAGDYAAAAGSLSDAREIFAKMPTTRTGIGRVLTHFADALAERLFPAFPQSAPPPPPPRGEQRELFRGFYEAGPYLKFAHLAANQAILEAFEGCNSVHVIDFALTDGIQWPSLIQALAVRPGGPPFLRITGIGPHAAGNRDELRDVGLRLAEFARSCSVPFAFRGIAADQLDGLRPWMFQVAPGEAVAINSVLQLHRLLVDQDAAAAASFPAPIDGVLDWVASMNPRVFTVVEQEADHNKSSLLERFTNSLFYYASMFDSLEAISRHGGGDGAGNPLAEAYLQGEIADIVSREGSSRVERHEQMPRWVERLRRGGMTQLPLGATGLWQAAMQLREFSGAGFGVQENGGFLTLTWHSQRLYSASAWRATAGKKMTMMASGAADAMEESQNSNTNGGGGGSSGGGHGALNQIMQ
Protein: Ribonuclease III domain-containing protein RNC1, chloroplastic (Chloroplast ribonuclease III domain protein) (Q9SZV0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds specific group II introns in chloroplasts and facilitates their splicing. Acts on both subgroup IIA and subgroup IIB introns. The substrates of the subgroup II also require the CRM domain proteins CAF1 or CAF2. Binds both single-stranded and double-stranded RNA non-specifically, but lacks endonuclease activity. Required for plastid ribosome biogenesis.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Protein WHAT'S THIS FACTOR 1 homolog
- CRS2-associated factor 2, chloroplastic
- Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic
- Protein RETICULATA-RELATED 6
- CRM-domain containing factor CFM2, chloroplastic
- Protein THYLAKOID ASSEMBLY 8, chloroplastic
- Pentatricopeptide repeat-containing protein At5g04810, chloroplastic
- GTP-binding protein At2g22870
- Pentatricopeptide repeat-containing protein At5g42310, chloroplastic
- Putative nucleobase-ascorbate transporter 9
Sequence:
MELCSSSPSSSLLRICSSSAPEISFSSSISQFPSKTQSILTKSRFQNLRICASVTAETQGLPRDSPQRLLKELAQRKTATGPKKKVPPKRFILRPPLDDKKLAERFLNSPQLSLKSFPLLSSCLPSSKLNNADKTWIDEYLLEVKQALGYSLEPSESLGDDNPAKHFDTLLYLAFQHPSCDRARARHVKNGHSRLWFLGQYVLELALTEFFLQRYPRESPGPMRERVFALIGKRYLPKWIKAASLQNLIFPYDDMDKLIRKEREPPVKSVFWALFGAIYLCFGMPEVYRVLFEVFGMDPDADECQPRSRRQLEDVDYVSVEFEGKKLGWQDIATYKPPEDALFAHPRLFRACVPPGMHRFRGNIWDFDSKPKVMQTLGYPLTMNDRIKEITEARNIELGLGLQLCFLHPSKHKFEHPRFCFERLEYVGQKIQDIAMAERLLMKHLDAPGKWLQEKHRRLLMNKFCGRYLREKRLHNFIIYSEEVHDRYEHNRRLRNPATTAVQQAIHGLAYTIYGKPDVRRLMFEVFDFEQIQPKAV
Protein: Glycerolphosphate mutase, putative (Q386L9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 60S ribosomal protein L2, putative
- 60S ribosomal protein L13a, putative
- 60S ribosomal protein L39, putative
- 40S ribosomal protein S16, putative
- 60S ribosomal protein L4
- 60S ribosomal protein L10, putative
Sequence:
MSRCGRKLDMSSGYWLPRRLLLVRHGESEANVDRALYSKVPDWKIPLTARGREQAFECGRRLRKIIKNEKLYVYYSPYTRTRQTLTEVRKSLLPSQVQGEREDERLREQEIGNFQPLDKMDEMWAERSEFGRSYYRFPDGESSVDVGDRVSKFFDSLFRERVELNYLSARKQMITGSSNDVGPASFTVPDDDDHNVVIISHGLLIRLFVGRWYSAPMEVFETMKNPPNCGIVVLERREAGRLVMTDTSKKLFGSDPLLEMMKFDGKDNVQLFRHLFAEGGYSFSAGEGTDR
Protein: Polar tube protein 1 (Major polar tube protein) (Major PTP) (O76942)
Organism: Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Function: Involved with PTP2 and PTP3 in the formation of the polar tube through which the infectious agent is passed on to the host cell. Accounts for at least 70 percent of the mass of the polar tube.
Subcellular location: Spore polar tube.
Interaction partners:
Sequence:
MKGISKILSASIALMKLENVYSATALCSNAYGLTPGQQGMAQQPSYVLIPSTPGTIANCASGSQDTYSPSPAAPTSPVTPGKTSENETSPSAPAEDVGTCKIAVLKHCDAPGTTSGTTPGSGPCETPEQQQPLSVISTTPAVPVTVESAQSPSVVPVVPVVAHHQAVPGYYNNGTSGIPGQQQILSGTLPPGATLCQGQAMPSTPGQQQILSGTLPPGVTLCQGQATPSTPGQQQVLSGTLPPGVTLCQGQATPSTPGQQQVLSGTLLPGATLCQDQGMPGTSGVPGQQGQSSGQCCAPQIPNPVMPPSMNISGNGYPSSTAYSPNLGSLGSCVDIQKTGGTSCEQKPEKSATQYAMEACATPTPTVIIGNSEYLVGPGMYNAINSPCNTAVQCC
Protein: Chemokine-like protein TAFA-4 (Q96LR4)
Organism: Homo sapiens (Human)
Function: Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release.
Subcellular location: Secreted {ECO:0000269|PubMed:15028294, ECO:0000269|PubMed:25109685}.
Interaction partners:
- Phosphatase and actin regulator 3
Sequence:
MRSPRMRVCAKSVLLSHWLFLAYVLMVCCKLMSASSQHLRGHAGHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEASIVIQKWWCHMNPCLEGEDCKVLPDYSGWSCSSGNKVKTTKVTR
Protein: Cyclin-dependent kinase inhibitor 5 (Inhibitor/interactor of CDK protein 3) (KIP-related protein 5) (Q9LRY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inhibits CYCD2-1/CDKA-1 complex kinase activity without interaction with the complex.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:17253089}. Note=Distributed in a ponctuate pattern.
Interaction partners:
- Cyclin-dependent kinase A-1
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase inhibitor 2
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinase B2-2
- Cyclin-D2-1
- Protein KINKY POLLEN
- Cyclin-D4-2
- Cyclin-D4-1
Sequence:
MGKYIKKSKVAGAVSVKDKSHPPALGFRTRAAAAKNLALHRLRSHSDEADSFNYLQLRSRRLVKLPLLTNTRKQQKQQLIPSVNQCQTKNPRASSGPAKKLEPDTTTEEACGDNERISRSDCNFGDKGFDLESENRSMISDSKSIQSEIEDFFASAEQQQQRFFIQKYNFDIVSDNPLPGRYEWVKVMP
Protein: Histone deacetylase HDA1 (EC 3.5.1.98) (P53973)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Subcellular location: Nucleus.
Interaction partners:
- HDA1 complex subunit 3
- HDA1 complex subunit 2
- Protein GZF3
- Histone H2B.1
- Histone H4
- Histone H3
- Histone deacetylase RPD3
- Histone H2B.2
- Histone H2A.1
- Cell division control protein 48
Sequence:
MDSVMVKKEVLENPDHDLKRKLEENKEEENSLSTTSKSKRQVIVPVCMPKIHYSPLKTGLCYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRIYKILAENGLINDPTLSGVDDLGDLMLKIPVRAATSEEILEVHTKEHLEFIESTEKMSREELLKETEKGDSVYFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAVVRPPGHHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRRIMILDWDIHHGNGTQKSFYQDDQVLYVSLHRFEMGKYYPGTIQGQYDQTGEGKGEGFNCNITWPVGGVGDAEYMWAFEQVVMPMGREFKPDLVIISSGFDAADGDTIGQCHVTPSCYGHMTHMLKSLARGNLCVVLEGGYNLDAIARSALSVAKVLIGEPPDELPDPLSDPKPEVIEMIDKVIRLQSKYWNCFRRRHANSGCNFNEPINDSIISKNFPLQKAIRQQQQHYLSDEFNFVTLPLVSMDLPDNTVLCTPNISESNTIIIVVHDTSDIWAKRNVISGTIDLSSSVIIDNSLDFIKWGLDRKYGIIDVNIPLTLFEPDNYSGMITSQEVLIYLWDNYIKYFPSVAKIAFIGIGDSYSGIVHLLGHRDTRAVTKTVINFLGDKQLKPLVPLVDETLSEWYFKNSLIFSNNSHQCWKENESRKPRKKFGRVLRCDTDGLNNIIEERFEEATDFILDSFEEWSDEE