wanglab/gogpt-training-data huggingface dataset:
Protein: Short transient receptor potential channel 1 (E1U7G1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MHISALPYSLSVIMAALYQGTDSSSPDKYLALKDVREVKEETTLDEKLFLLACEKGDYYMVKKLLEEKRHGELNINCVDVLGRDAVTISIENENLDILQLLLDHGCQATDALLVAIDSEVVGAVDILLNHRPRRSSKPSIAKLIQKIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDISLPRPHAVGCECTLCNAKNKKDSLRHSRFRLDIYRCLASPSLIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELAKQCKMFAKDLLAHARNSRELEVILNHTSSEDHVDKRGFLEERMNLSRLKLAIKYNQKEFVAQSNCQQFLNTVWFGEMASYRRKHTCLKIVSVLSVALLWPLLSICYLLGPRSRVGQVIHTPFIKFIIHSASYFTFLLLLNLYSLIYNDKKNMAPALQFIDYLLILWIIGMVWSDVKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKIVAHNKYSKIIKPEERKEWDAFHPTLVAEGLFAFAIVLSYLRLFFMYTTSSILGPLQISMGQMLQEFGKFLGLFLLVLISFTIGLTQLYGKDQDPSKTKDDNKDCEGIYCQQQSNDTFHTFMGTCYALFWYIFSLAHVNLFVTRISYTEELRSFVGALIVGTYNIVVVIVLTKLLVAMLHKSFRQIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNVLPSPKTVCYLVISMSKWICSHTSTGKVKRQNSLREWTNLKQKRDQNYQKIMCCLVHRYLTSTRQKMQSMDQATVENLNDLRQDLSKFRNEMRDLLGFRTSKYAMFYPRS
Protein: Melanocyte protein PMEL (Melanocyte protein Pmel 17) (Premelanosome protein) (Silver locus protein) [Cleaved into: M-alpha; M-beta] (Q60696)
Organism: Mus musculus (Mouse)
Function: Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P40967}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:P40967}; Single-pass type I membrane protein {ECO:0000255}. Endosome, multivesicular body {ECO:0000250|UniProtKB:P40967}. Melanosome {ECO:0000250|UniProtKB:P40967}. Extracellular vesicle {ECO:0000250|UniProtKB:P40967}. Secreted {ECO:0000250|UniProtKB:P40967}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes. Sorted to stage I melanosomes following its processing in the ER and cis-Golgi. Transiently expressed at the cell surface before targeting to early melanosomes. Colocalizes with BACE2 in stage I and II melanosomes. Colocalizes with CD63 at exosomes and in intraluminal vesicles within multivesicular endosomes. {ECO:0000250|UniProtKB:P40967}.
Interaction partners:
- Tyrosinase
- Melan-A
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
- L-dopachrome tautomerase
- T-cell surface glycoprotein CD4
- Membrane-associated transporter protein
- CD63 antigen
- MAGE family member A3
- Microphthalmia-associated transcription factor
- Cytotoxic T-lymphocyte protein 4
Sequence:
MGVQRRSFLPVLVLSALLAVGALEGSRNQDWLGVPRQLVTKTWNRQLYPEWTEVQGSNCWRGGQVSLRVINDGPTLVGANASFSIALHFPGSQKVLPDGQVIWANNTIINGSQVWGGQPVYPQEPDDACVFPDGGPCPSGPKPPKRSFVYVWKTWGKYWQVLGGPVSRLSIATGHAKLGTHTMEVTVYHRRGSQSYVPLAHASSTFTITDQVPFSVSVSQLQALDGETKHFLRNHPLIFALQLHDPSGYLAEADLSYTWDFGDGTGTLISRALDVTHTYLESGSVTAQVVLQAAIPLVSCGSSPVPGTTDGYMPTAEAPGTTSRQGTTTKVVGTTPGQMPTTQPSGTTVVQMPTTEVTATTSEQMLTSAVIDTTLAEVSTTEGTGTTPTRPSGTTVAQATTTEGPDASPLLPTQSSTGSISPLLDDTDTIMLVKRQVPLDCVLYRYGSFSLALDIVQGIESAEILQAVPFSEGDAFELTVSCQGGLPKEACMDISSPGCQPPAQRLCQSVPPSPDCQLVLHQVLKGGSGTYCLNVSLADANSLAVASTQLVVPGQDGGLGQAPLLVGILLVLVAVVLASLIHRHRLKKQGSVSQMPHGSTHWLRLPPVFRARGLGENSPLLSGQQV
Protein: RRM domain-containing protein (Q38AD6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEALRVQGLKFTFGVEFCRLALLRCFGELGSLYDVLLDVDVGEALVTYAESVSAQEAYIKMNGFLLFGETIRVSITVPPVSEVPGCSVTHRPSRFVIIRGATSLWVELNLRHVKGVEQHQIVGANAAVVSFANEHISTKIKRMFDG
Protein: Katanin-interacting protein (Q8C753)
Organism: Mus musculus (Mouse)
Function: May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:O60303}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:O60303}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O60303}. Note=When overexpressed, localizes to the cytoplasm where it associates with acetylated alpha-tubulin. {ECO:0000250|UniProtKB:O60303}.
Interaction partners:
- Katanin p60 ATPase-containing subunit A-like 2
- Centrosomal protein of 104 kDa
Sequence:
MDGQALRKVERSRSCSQERKEGYSKDMVTDFDEKHDEYLILLQQRNRILKHLKAKDPVQLRLEHLEQGFSVYVNGANSELKTSPRKAVHTDFSRSASQAEGSQDYGRRTLFREAEEVLRRSSRTAPGKVQRRGWHQKSVQIRTEAGSRLHIEPPLDCSEDFESQEDVIGKHEDATGEHTQELRKGLGLSTSLQTQEDGSSDEYDSIEEDVLSETETEDPVLPVHNRDECPLPSHDAVQKDVPKDQELEGRHPQATDTLVVMEFNPASKGNKMDRILSAKRKENAEVFIPSKPDSVLNPQPPAVFPEQERACSRSGSRRDRPLSATRKAYAAEDREEDASAVLKAIQVENEALQQVFLSHDPELHTSPQQDTKEPPAKSWSSLLKAKEDIPELLPATPVTTDPELCRAAAGAKAVSQAMDGMSPLGSRQQHKLVGVLQTMESDTTHLSQVAIPTEKPVPNSEEKWKARVDEIEDAIYVTMEILSNWGNASWVGLTEVQFFDLNNIKLYVSPHDVDIRNAVLPGELGCLVNRDLVSKKDPPVWTCPFHPPLQLYFIIHNMRQLRDFGLTMIKVRNYWTADGDLDIGAKNVKLYVNKSLIFDGVLEKGGGEAPSDCTIPVDLQRERNESSDKALSTGWKESKGALKMAALSDARELGLSCSQPAESLDMTVSSQGDFLGEKVNSTSGLKNSLSKLQEDVRLLATPASMGDGPSVPSSSSPGKCLPLEEEPSLIQQLESLRGRKIPEPTGKTPHWLQPSLAGMGKKQTVRKPKPLWLSPEKDLEQKSRFPSEDVMGDTPGEVETREKGPRREQGRTSSWNVITEERAPKAFSKACGDDLDIFSQLPNRDRPASGRRALKKEASSSHGDDRPASKEDTQASQTLPWLQWYGEQEHALHASWDSLTAFDRAHRGRISALEPQGDILDEFLKQQRSSRHEEFPAPCREEEPEPSTEMGGDSDFKIPVLPYGQHLVIDIKSTWGDRHYVGLNGIEIFSSSGEPVQISSITADPPDINILPAYGKDPRVVSNLIDGVNRTQDDMHVWLAPFTPGMTHTISIEFTHPCQVALIRIWNYNKSRIHSFRGVKDITMLLDTQCIFEGEIAKASGTLMGAPEHFGDTILFTMDEDILEAIFCLDDTFDMDAESLCGLQPEEALRRPSTADGEGQDERPFTQAGLGAQDQVPGLELQTSPPVSEVTTPEPGIFYGLCLRLNLTASWGDLHYIGLTGLEVVGKDGEALPIQPHQLSASPRDLNDLPEYNDDSRTLDKLIDGMNITTEDEHMWLIPFSPGLDHVVMIHFDRAQSIAGLRLWNYNKSPEDTYRGVKIAHVSLDGLCVSPAEGFLIRKGPGNCHFDFAQEILFGDYLQTRLPPAPTRRLDAKSLERASMDYEAPLMPCGFIFQFQLLSSWGDPYYIGLTGLELYDEHGERIPLSQNNIAAFPDSVNALEGVCGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYTKTPQRGVKEFGLLVDDLLVYNGILAMVSHLVGGILPTCEPTVPHHTILFAEDTDFCHQEKHAIISKPEEDQDIQMMNENQVITTSRRKPGTADPALRPKTCIREKETSRRWRC
Protein: Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) (Q03347)
Organism: Mus musculus (Mouse)
Function: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells. Positively regulates the expression of RORC in T-helper 17 cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:17377532}.
Interaction partners:
- Forkhead box protein P3
- Core-binding factor subunit beta
- Endothelial transcription factor GATA-2
- Protein C-ets-1
- Protein CBFA2T1
- T-cell acute lymphocytic leukemia protein 1 homolog
- Histone deacetylase 1
- Trans-acting T-cell-specific transcription factor GATA-3
- CCAAT/enhancer-binding protein alpha
- Transcription factor PU.1
Sequence:
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDGGPALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPWSYDQSYQYLGSITSSSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFGDPRQFPTLPSISDPRMHYPGAFTYSPPVTSGIGIGMSAMSSASRYHTYLPPPYPGSSQAQAGPFQTGSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPSQSDVVETEGSHSNSPTNMPPARLEEAVWRPY
Protein: Beta-defensin 119 (Beta-defensin 120) (Beta-defensin 19) (DEFB-19) (Beta-defensin 20) (DEFB-20) (Defensin, beta 119) (Defensin, beta 120) (ESC42-RELA) (Q8N690)
Organism: Homo sapiens (Human)
Function: Has antibacterial activity.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MKLLYLFLAILLAIEEPVISGKRHILRCMGNSGICRASCKKNEQPYLYCRNCQSCCLQSYMRISISGKEENTDWSYEKQWPRLP
Protein: Trans-Golgi network integral membrane protein TGN38 (P19814)
Organism: Rattus norvegicus (Rat)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- AP-2 complex subunit mu
- AP-2 complex subunit alpha-2
- AP-2 complex subunit beta
- AP-2 complex subunit sigma
- Vesicle-associated membrane protein 4
- Syntaxin-6
- Transferrin receptor protein 1
- Ras-related protein Rab-6A
- GRIP and coiled-coil domain-containing protein 2
- Vesicle transport through interaction with t-SNAREs homolog 1A
Sequence:
MQFLVALLLLSVAVARALPSASKPNNTSSENNPPIQPSTPLPPGVDISQQVKTNRPTDQRLESDKEGQDKTVARTSASVSSGVESATNLNLDDSKKHPETADAKLKETLQQLLPVDPKQEKSGQKFTKDSGSPTGGDSDNTTGGDSNKTTGVDSDKTSGGDSNKPTGSDNDKPTGGDSNKPTSKVPSNTETPKIDKVQLTEKGQKPTLISKTESGEKLAGDSDFSLKPEKGDKSSEPTEDVETKEIEEGDTEPEEGSPLEEENEKVLGPSSSENQEGTLTDSMKDEKDDHYKDNSGNTSAESSHFFAYLVTAAVLVAVLYIAYHNKRKIIAFALEGKRSKVTRRPKASDYQRLNLKL
Protein: Polycomb protein Su(z)12 (Suppressor 12 of zeste protein) (Q9NJG9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.
Subcellular location: Nucleus {ECO:0000305|PubMed:22354997}. Chromosome {ECO:0000269|PubMed:22354997}.
Interaction partners:
- Polycomb protein esc
- Polycomb protein esc
- Histone-lysine N-methyltransferase E
- Chromatin assembly factor 1 p55 subunit
- Zinc finger protein jing
- E3 ubiquitin-protein ligase RING1
- Histone deacetylase HDAC1
- Polycomb group protein Psc
- Jumonji, AT rich interactive domain protein 2
- Polycomb group protein Pc
Sequence:
MAPAKKREKDSNPDGSAANGIIGLTHGAPDASNAGSTVPPTAEGQVKLNGHQQEQELFLQAFEKPTQIYRYLRNRHETNPIFLNRTLSYMKERMSRNNKKRISFQVNSMLESITQKSEAVSQNYLHVIYDSLHEKLPARLDNESGEDLLQEQLLCEAGESVSVETTLYKITRSKRKDSTLDFQELLSKCSQIVYNPKDRVGEHATISIPLQTMRPMGEQHTLYKLLFRIKVLSPSTCNDENAETPPNKRSRPNEKMFGSELILYEKSSGFITEGEYEAMLQPLNSTSIKSFSPKKCTWETMPDSYIPLSLTYDVYQQSPMLKFHLTLSNEQLPEMISAPELQRYVQHLDAVAEMNYNNNNYNNNNNCSGLKNGSGGGNSTVCKTTPEHIQIVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCGPVRRTSVTSLMVCRPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQGLLSKYAAGQELMQRQREEQLKYWLDVGMHKKQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDNTVLNKRQRYSDGSPGTGIGNGHGGGSGSGANRNKSNNHSLPATSNNASSSSSNSKRAIARRRSTSERTKASGSTGGGAGGVRTRLSVPAKYERR
Protein: Bypass of stop codon protein 6 (Q08280)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable transporter.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000305|PubMed:14562095}; Multi-pass membrane protein {ECO:0000305|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YER084W
Sequence:
MDASSVPPKVDDYGMYTTEISHHNPIELKNLLSSSDSRRNSQDEDSLPNNTNLIKEIDWQGEKVKTYPLNYQTVPLVKLQVIACLIMFVVFGMNDQTVGALLPTLIEYYHISRVDVSNVFIVQLCGYVMASLSKERLNKHFGMRGGMLLAAGLCIVFLIILATAPSSFYVCMFCGLPLGLGIGILDSTGNVLMGSLLVHKNELMGIMHGLYGAAAMVTPPLVSYFVEWGHWSLFFLIPLFFSIIGMIVIFPAFKFETASKYDYLCSVENKESNNDVEEAGDNSLMESTKASPGFFELLRNPAIFLYSLYLFLYLGAEITTGSWFFSYLLETKSSNKVAMSYIAASFWTGLTVGRLCLGFVTERFFENEYKASKAYAFLTLSSYTLFVLVGLINSSSVFYFVVLFFVVFCCGTFIGPLFPNASIVALQVLPKRLHVSGVGVAVAVGGCGGAAIPYLAGVIAHTVGIQYIPLLCWIMVALFTLEWTLYPKFIKGHEEYF
Protein: 60S ribosomal protein L19 (C6KSY6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 40S ribosomal protein S21
- 40S ribosomal protein S27
- 40S ribosomal protein S24
- 40S ribosomal protein S6
- 60S ribosomal protein L35ae, putative
- 60S ribosomal protein L13
- 60S ribosomal protein L26, putative
- 60S ribosomal protein L6, putative
- 60S ribosomal protein L18-2, putative
- 60S ribosomal protein L29
Sequence:
MSLTLQKRLAASVLKCGKNKIWMDPNEISEISLANSRFSIRKLYKEGLILKKPQKVHSRARVRLYKLAKRKGRHMGIGKRKGTKNARTNQKTLWIKRQRVLRRLLKRLRDSKKVDRHLYHSFYLKCKGNQFKNKRTLIEAIQREKNETLKKKAIADQLEAKRLKAQVLRNKRKLKKDKEVVA
Protein: DET1 homolog (De-etiolated-1 homolog) (Q7L5Y6)
Organism: Homo sapiens (Human)
Function: Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DET1- and DDB1-associated protein 1
- Cullin-4A
- DNA damage-binding protein 1
- E3 ubiquitin-protein ligase RBX1
- Cullin-4B
- E3 ubiquitin-protein ligase COP1
- DNA damage-binding protein 2
- Protein cereblon
- DDB1- and CUL4-associated factor 16
- DDB1- and CUL4-associated factor 5
Sequence:
MDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAFSSDQTSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVNIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDEPHPPFFEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRTIGRFCYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIKYTSEDVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTEAVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFYARDSGLLKFEIQAGLLGRPINHTVRRLVAFTFHPFEPFAISVQRTNAEYVVNFHMRHCCT
Protein: Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Muscle-type aldolase) (P00883)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.
Subcellular location: Cytoplasm, myofibril, sarcomere, I band {ECO:0000269|PubMed:15757649}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:15757649}. Note=In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+).
Interaction partners:
- Triosephosphate isomerase
- Phosphofructokinase domain-containing protein
- ATP-dependent 6-phosphofructokinase, muscle type
- Beta-enolase
- Glyceraldehyde-3-phosphate dehydrogenase
- Fructose-1,6-bisphosphatase 1
- Beta-enolase
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
- Transketolase
- Fructose-bisphosphate aldolase
Sequence:
MPHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFISNHAY
Protein: Acyl-coenzyme A synthetase ACSM2, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 2) (Benzoate--CoA ligase) (EC 6.2.1.25) (Butyrate--CoA ligase 2) (Butyryl-coenzyme A synthetase 2) (Middle-chain acyl-CoA synthetase 2) (Q8K0L3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q68CK6}.
Interaction partners:
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Sequence:
MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA
Protein: ferroxidase (EC 1.16.3.1) (A8K5A4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQSPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVHREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGVYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHFHAGMETTYTVLQNEDTKSG
Protein: Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (T-cell activation antigen CD26) (M1PFC6)
Organism: Pipistrellus pipistrellus (Common pipistrelle)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004655}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004655}. Cell projection, invadopodium membrane {ECO:0000256|ARBA:ARBA00004341}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004341}. Cell projection, lamellipodium membrane {ECO:0000256|ARBA:ARBA00004485}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004485}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKTPWKVLLGLLGTAALVTIITVPAVLLSQGNDADTRRTYTLSDYLKSTIRTRNYNLRWISDHEYLYRQENNILLFNADHGNSSTFLENSTFDQFGYSINDYSVSPDRRFVLLEYNYVKKWRHSYTASYDIYDLNKRQLITEERIPNDTQLISWSPEGHKLAYVWNNDIYIKNDPNSPPQRVTDDGREDAISNGITDWVYEEEIFSTHSALWWSPNGTFLAYARFNDTEVPRIEYSVYLDESLQYPKTVHLPYPKAGAENPTVKLYVVNTDNLTNLVPVQITAPASVLTGDHYLCDVTWATKERISLQWLRRTQNYSIIDICDYDAPNSKWNCSVPRQHIEMSTTGWVGRFKPAEPHFTADGNSFYKIMSNSEGYKHICYFQVDNQKCTFITNGTWEVIKIEALTNNYLYYISNEYKGMPGGRNLYKIQLNNITNVACLSCELDPERCQYYSASFSKGAKYYQLRCSGPQLPRYSLHSSSNDKELRLLENNTALYETLRNIKMPRKTLDVIHLHGMKFWYQMILPPHFDKSKKYPLLIDVYAGPCSQKADATFSLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRKLGTLEVEDQIEAARQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSAWEFYDSVYTERYMGLPTPGDNLEHYKNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQITKALVDAGVDFQAMWYTDEDHGIASNTAHQHIYTHMTHFLKQCFSLP
Protein: ALK and LTK ligand 1 (Augmentor beta) (AUG-beta) (F8W2C9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK. Required for iridophore development in the adult eye by acting as a receptor for LTK.
Subcellular location: Secreted {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q6UXT8}.
Interaction partners:
Sequence:
MRAEKRWHILLSMILLLITSSQCMDSKEVKESERKTLLNLILQVIGEKPASRRVTSGLYSVSQDAKFSSRENTAHLPKPDNSRPIEIVPRDTSMKDKFIEHFTAGPVKFPSECRTHFHRIYHNTRDCSRPTYYKRCARLLTRLAMSPLCTQS
Protein: Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein) (Q9UBB4)
Organism: Homo sapiens (Human)
Function: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16498633, ECO:0000269|PubMed:25666058}. Midbody {ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:25666058}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P28658}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:P28658}. Note=Localizes to the midbody during telophase. {ECO:0000269|PubMed:25666058}.
Interaction partners:
- Spectrin beta chain, non-erythrocytic 2
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Ataxin-7
- Tau-tubulin kinase 2
- IQ calmodulin-binding motif-containing protein 1
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Sequence:
MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRDTPKP