wanglab/gogpt-training-data huggingface dataset:
Protein: Protein zds1 (Meiotically up-regulated gene 88 protein) (O14100)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in establishing cell polarity. Also required for maintenance of cell wall integrity, sexual differentiation, calcium tolerance and cell morphology. Involved in Ras-MAPK signaling pathway at cell cortex. Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16322512, ECO:0000269|PubMed:16823372}. Note=Localizes to the septum and cell cortex.
Interaction partners:
- Separin
- Protein phosphatase PP2A regulatory subunit B
Sequence:
MSSSSVSNTLSIETKSDPKDPAFVASQESTECNEHDTTQLSGSSSEPLENNSSLTRSTDDPSVEIRSKLVSPDNEANLLSDQNITISNENNNENDTTEEAETSSGNEAADDEDSSSDAQSSVPSFSEIHDGMSEEELDKERKTLTHLRRISLQGADDPEIPTDWSVAMSPPETEQDASTLFWVPANLHPELNPTGWKSFLDLQVKNLKSPTATDTSSSPLEHIRSLRRRKSLLSRQVKADDAVINYQDGSPIVEKAYLKRHRSLRLNELEHLESLARDPHRMVSLVDGMSNGSPEDSPLLVSPNHFLQRSSRTTIRRTGASIRTIHRGKTSTLSGNRSHSILQKPTDTSPLHKIEPISADELVESDDSRTSALSNSQNPSDDVENQSDQALEVLSLTNPPKIDNASADTTLHKETNKIDKLYVSENKAESAVASESSLSEGTLALKAPAPENKPEKSSTSKPPVPENKAEDSVVLKSSVPEDKSENSIASKPSATEGIPENAIALQSSVPENKAEDSVVLKSSVPEDKSEDSVPSKSSVLEDKHENSVEIDKKADDSLPSNNKTEGYTPSVVREEKNYSEPNASPSVIPPRVPTPVPGRTLSPKPTRIPTPIPSSLNVSLESSKKPEIFHERHIPTPETGPNKPSKNNILKSTQVPVTPKQKSSTANKGSTSSPSPPSSESKKTKRSWGRLFVSGDSDKEHKEHKKDKQKKKNDQISSSSKSASSFKKDRDKESIFGSLFGSKKKQTEIPPVSSSPPHNDAPPKAKPISAPSELPNTTSVAEAKCQTVTDDEGTDQQSDEKSTEPKTFIPDKDYYWSRFPICTERAIYRLSHIKLSNAHRPLFQQVLLSNFMYSYLDLISRISSNRPMNNVQQSTAKPIRKDINGQQRRSEFSAENVKNELENLSYQFGDQRKRNLNRKGSTIHTVSQNIQKVSKNAK
Protein: Clathrin heavy chain (K7EJJ5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side {ECO:0000256|PIRNR:PIRNR002290}.
Interaction partners:
Sequence:
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDAIKEKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM
Protein: ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Protein TBX2) (Q9JKW0)
Organism: Mus musculus (Mouse)
Function: Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (By similarity).
Subcellular location: Endomembrane system {ECO:0000250|UniProtKB:Q15041}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15041}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:18684713}. Note=Predominantly localized to intracytoplasmic membranes. Preferentially localizes at the ER tubules and the edge of the ER sheets, both of which are characterized by a high membrane curvature. {ECO:0000250|UniProtKB:Q15041}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein eS1
Sequence:
MAEGDNRSSNLLAVETASLEEQLQGWGEVMLMADKVLRWERAWFPPAIMGVVSLLFLIIYYLDPSVLSGVSCFVMFLCLADYLVPILAPRIFGSNKWTTEQQQRFHEICSNLVKTRRRAVGWWKRLFSLKEEKPKMYFMTMIISLAAVAWVGQQVHNLLLTYLIVTFVLLLPGLNQHGIILKYIGMAKREINKLLKQKEKKNE
Protein: Ran GTPase-activating protein (RanGAP) (Protein segregation distorter) (Q9VIW3)
Organism: Drosophila melanogaster (Fruit fly)
Function: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17032737}. Nucleus membrane {ECO:0000269|PubMed:17032737, ECO:0000269|PubMed:31626769}; Peripheral membrane protein {ECO:0000269|PubMed:17032737}; Cytoplasmic side {ECO:0000269|PubMed:17032737}. Note=Association to cytoplasmic side of the nuclear pore complex is promoted by Nup214 (PubMed:17032737). Co-localizes with Nup358/RanBP2 to annulate lamellae (PubMed:31626769). {ECO:0000269|PubMed:17032737, ECO:0000269|PubMed:31626769}.
Interaction partners:
- E3 SUMO-protein ligase RanBP2
- Dorsal interacting protein 4
- GTP-binding nuclear protein Ran
- Regulator of chromosome condensation
- Small ubiquitin-related modifier
- Exportin-1
- GTP-binding nuclear protein Ran-like
- FI04457p
- Nuclear pore complex protein Nup107
- NTF2-related export protein
Sequence:
MSTFNFASMAAQLGQEQGISFENKVLSWNTAADVQDVVDALNKQTTVHYLNLDGNTLGVEAAKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAFQTLKTFEEIVLEQNSIYIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEINSDGGLVLVNAMGNKPKLRILNLDGNSFGEEGSEKIISEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEEEEEVHEHANDTTEEADEDSEGDEDDEEDEGDEEYSNVAEETAYVTTNAYTTKLFNDTTNSMASETFAVANKTISQKCTPEKFCLSQKPCSQEDFDSLDMDNKLEALQSIVNQFTGDNHLLLLVFTTLKCAHLSQSSKAALDLAVSLYQATFDYAIKTKQETRVLNYVLMQLRLLPCKEVFHSDYDVKNCRFALREALKQPTFANDNIKNSFKTFLEGAES
Protein: TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C) (Q15572)
Organism: Homo sapiens (Human)
Function: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.
Subcellular location: Nucleus, nucleolus {ECO:0000305|PubMed:11250903, ECO:0000305|PubMed:11283244}.
Interaction partners:
- TATA box-binding protein-associated factor RNA polymerase I subunit A
- TATA box-binding protein-associated factor RNA polymerase I subunit B
- TATA box-binding protein-associated factor RNA polymerase I subunit D
- TATA-box-binding protein
- RNA polymerase I-specific transcription initiation factor RRN3
- Nucleolar transcription factor 1
- DNA-directed RNA polymerase I subunit RPA49
- DNA-directed RNA polymerase I subunit RPA1
- DNA-directed RNA polymerase I subunit RPA43
- Transcription initiation factor TFIID subunit 12
Sequence:
MDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEAQPQNSENGALHVTKDLLWEPATPGPLPMLPPLIDPWDPGLTARDLLFRGGCRYRKRPRVVLDVTEQISRFLLDHGDVAFAPLGKLMLENFKLEGAGSRTKKKTVVSVKKLLQDLGGHQPWGCPWAYLSNRQRRFSILGGPILGTSVASHLAELLHEELVLRWEQLLLDEACTGGALAWVPGRTPQFGQLVYPAGGAQDRLHFQEVVLTPGDNPQFLGKPGRIQLQGPVRQVVTCTVQGESKALIYTFLPHWLTCYLTPGPFHPSSALLAVRSDYHCAVWKFGKQWQPTLLQAMQVEKGATGISLSPHLPGELAICSRSGAVCLWSPEDGLRQIYRDPETLVFRDSSSWRWADFTAHPRVLTVGDRTGVKMLDTQGPPGCGLLLFRLGAEASCQKGERVLLTQYLGHSSPKCLPPTLHLVCTQFSLYLVDERLPLVPMLKWNHGLPSPLLLARLLPPPRPSCVQPLLLGGQGGQLQLLHLAGEGASVPRLAGPPQSLPSRIDSLPAFPLLEPKIQWRLQERLKAPTIGLAAVVPPLPSAPTPGLVLFQLSAAGDVFYQQLRPQVDSSLRRDAGPPGDTQPDCHAPTASWTSQDTAGCSQWLKALLKVPLAPPVWTAPTFTHRQMLGSTELRREEEEGQRLGVLRKAMARGQLLLQRDLGSLPAAEPPPAPESGLEDKLSERLGEAWAGRGAAWWERQQGRTSEPGRQTRRPKRRTQLSSSFSLSGHVDPSEDTSSPHSPEWPPADALPLPPTTPPSQELTPDACAQGVPSEQRQMLRDYMAKLPPQRDTPGCATTPPHSQASSVRATRSQQHTPVLSSSQPLRKKPRMGF
Protein: Mismatch repair protein MLH1 (Q57TS9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Mismatch repair protein PMS1, putative
- Mismatch repair protein MSH8, putative
- DNA mismatch repair protein, putative
- MutL C-terminal dimerisation domain-containing protein
- Exonuclease, putative
- Mismatch repair protein MSH3, putative
- Proliferating cell nuclear antigen
- Mismatch repair protein MSH5, putative
- Mismatch repair protein, putative
- DNA 3'-5' helicase
Sequence:
MRGIERLPEDVINRIAAGEVVQRPSAALKELLENSLDAGSTCIQVVVQDGGLELLQVTDDGHGIRFGDLPLLCERYATSKLRAFDELNNIRSFGFRGEALCSISYVARVTVTTMRHNDTVAWRCHYVDGRMQEEPKPCAGNPGTCIRAEKMFYNAAVRRRAFSRPSEECSRVEDVVSRYALAFPSVAFSCRRSDGSVAGVTKNCVCFPKDSNTLANIRQHWGGEVASRLCEVRCTGESPSEDNCTPESVLATSGPSGEGRFLITGYTSDITLASRKSYLCVFVNNRLVDSTAIRRALDAVYSGVLVRGNRPFTVLFVTVPPDRVDVNIHPTKHEVCLLDEEIIVSQLSECVQGALQASAARRQMDIRQIHSKAVMLGDRESQRSNQPMQPHSSTSPFNPLPTGARGGVAAVAPCSLVRVEPQRGALDAFVRRPKPTAEGNGDAPLRSESIEERAGGGGDAQVRSAGTGSSMESQDTATGGNFQVARTADDGKAPSGLTCAASSSPAVTTVTDAEASSGSGARGWSENQSTGTLSMTPVLLLDTTDEDGEEVEYTIEHFKKHRKEVQDVVSSVIDTAGVGVGCGASDYIAAEDNKAAASTGDAAVRMVEGADSAGSQEEAGFLLLTSVSTIVSNIRAGTSQTAQSLFQNLAYVGVLKGHLFFAQSGTTLYVVDSLRLVRHVVYQRIFLRWATPSLSAVPQLSFEEPIHLSDLLSFALQNDVQLPPSQKRADGGPGSLLSRLGRRLCNWRYMLQDYFAVEISADGHLIALPLSMGTSWPPPLRAVPLFIWRLAAEVPYNAGEIECFTAIARHIAETLYGVQLHSSWLPNVIKDGIRQDDVPPFCDAIRFGLLPCATNSTFFVPPCDALVDGTVQAVVSVDELYKVFERC
Protein: DNA-damage-repair/toleration protein 111 (Protein SPLICING FACTOR FOR PHYTOCHROME SIGNALING) (REQUIRED FOR SNC4-1D protein 2) (P42698)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Seems to be involved in the resistance to UV light and chemical DNA-damaging agents. Regulates the splicing of the receptor-like kinase SNC4/LRKL-2.6.
Subcellular location: Nucleus {ECO:0000269|PubMed:28760995}. Nucleus speckle {ECO:0000269|PubMed:28760995, ECO:0000269|PubMed:32123040, ECO:0000269|PubMed:36282917}. Note=Observed in subnuclear light-induced structures called photobodies in response to light (PubMed:28760995). Colocalizes in nuclear speckles with U2 small nuclear ribonucleoprotein-associated factors including U2AF65B, U2A' and U2AF35A and with SF1 (PubMed:28760995, PubMed:32123040). {ECO:0000269|PubMed:28760995, ECO:0000269|PubMed:32123040}.
Interaction partners:
- Nuclear protein-like
- Protein RRC1
- U2 small nuclear ribonucleoprotein A'
- Protein RRC1-like
- At2g32600/T26B15.16
- Splicing factor SF3a60 homolog
- Nucleic acid binding/RNA binding protein
- RNA helicase
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH3
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2
Sequence:
MLGGLYGDLPPPTDDEKPSGNSSSVWSSSTKMAPPTLRKPPAFAPPQTILRPLNKPKPIVSAPYKPPPPSNSSQSVLIPANESAPSHQPALVGVTSSVIEEYDPARPNDYEEYKREKKRKATEAEMKREMDKRRQEDEERDKREREEREKERERDNSDPSRLNISGEEAWKRRAAMSGGGSGGKGRSSSPPGNVDGFSIGKSETSGLGVGAGGQMTAAQRMMAKMGWKQGQGLGKSEQGITTPLMAKKTDRRAGVIVNASENKSSSAEKKVVKSVNINGEPTRVLLLRNMVGPGQVDDELEDEVGGECGKYGTVTRVLIFEITEPNFPVHEAVRIFVQFSRPEETTKALVDLDGRYFGGRTVRATFYDEEKFSKNELAPVPGEIPGY
Protein: Treacle protein (Treacher Collins syndrome protein homolog) (O08784)
Organism: Mus musculus (Mouse)
Function: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q13428}.
Interaction partners:
- Nucleolar protein 56
- DNA-directed RNA polymerase I subunit RPA1
Sequence:
MAEARKRRELLPLIYHHLLQAGYVRAAREVKEQSGQKSFLTQPVTLLDIYTHWQQTSELGQKQKAEDDETLQAKKSRVSDPVSSSESSDQEKEEEAATERAKATPRPTPVNSATAALPSKVKEKGKTKTANKTVNSVSHPGSGKTVVHLLSGKSPKKSAEPLANTVLASETEEEGNAQALGPTAKSGTVSAGQGSSSSEDSSISSDETDVEVKSPAKPAQAKASAAPAKDPPARTAPGPTKLGNVAPTPAKPARAAAAAAAAAVAAAAAAAAEESESSEEDSDSEDEAPAGLPSQVKASGKGPHVRADSVSAKGISGKGPILATPGKTGPAATQAKAERPEKDSETSSEDDSDSEDEMPVTVNTPQARTSGKSPRARGTSAPAKESSQKGAPAVTPGKARPVAAQAGKPEAKSSEESESDSGETPAAATLTTSPAKVKPLGKSSQVRPVSTVTPGSSGKGANLPCPGKVGSAALRVQMVKKEDVSESSSAELDSDGPGSPAKAKASLALPQKVRPVATQVKTDRGKGHSGSSEESSDSEEEAAPAASAAQAKPALEKQMKASSRKGTPASATGASTSSHCKAGAVTSSASLSSPALAKGTQRSDVDSSSESESEGAAPSTPRVQGKSGGKGLQGKAALGQGVAPVHTQKTGPSVKAMAQEDSESLEEDSSSEEEDETPAQATPLGRLPQAKANPPPTKTPPASASGKAVAAPTKGKPPVPNSTVSARGQRSVPAAGKAGAPATQAQKGPVAGTGEDSESSSKEESDSEEETPAQIKPVGKTSQVRAASAPAKESPKKGAHPGTPGKTGSSATQAQPGKTEDSDSSSEESDSDTEMPSAQAIKSPPVSVNRNSSPAVPAPTPEGVQAVNTTKKASGTTAQSSSSESEDGDEDLIPATQPSTYALRTSVTTPAALSRAASQPSKSEQSSRMPKGKKAKAAASAQTSSAVETLPMMPPQSAPIQPKATNKLGKSKLPEKQQLAPGYPKAPRSSEDSSDTSSEDEEDAKRPQMPKSAHRLDPDPSQKETVVEETPTESSEDEMVAPSQSLLSGYMTPGLTVANSQASKATPRPDSNSLASSAPATKDNPDGKQKSKSQHAADTALPKTGRKEASSGSTPQKPKKLKKSTSSSPAPTQTLPNSITQRLLEQAWPLSEAQVQASVVKVLTELLEQERLKATEAIKESGKKSQKRKLSGDLEAGAPKNKKKKEQPVPRASAVSPEKAPMTSKAKSKLDKGSAGGKGKGSPGPQGAKEKPDGELLGIKLESGEQSDPKSKSKKKKSLKKKKDKEKKEKKKGKKSLAKDSASPIQKKKKKKKKSAEPAV
Protein: Outer membrane lipoprotein Blc (P0A901)
Organism: Escherichia coli (strain K12)
Function: Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.
Subcellular location: Cell outer membrane; Lipid-anchor.
Interaction partners:
- Beta-lactamase
- Guanidinium exporter
- Epimerase family protein YfcH
- Uncharacterized protein YcgB
- Disulfide-bond oxidoreductase YfcG
- Fumarate reductase subunit D
Sequence:
MRLLPLVAAATAAFLVVACSSPTPPRGVTVVNNFDAKRYLGTWYEIARFDHRFERGLEKVTATYSLRDDGGLNVINKGYNPDRGMWQQSEGKAYFTGAPTRAALKVSFFGPFYGGYNVIALDREYRHALVCGPDRDYLWILSRTPTISDEVKQEMLAVATREGFDVSKFIWVQQPGS
Protein: 6-oxocamphor hydrolase (OCH) (EC 3.7.1.18) (Beta-diketone hydrolase) (Q93TU6)
Organism: Rhodococcus sp
Function: Catalyzes the carbon-carbon bond cleavage of the bicyclic beta-diketone 6-oxocamphor via a retro-Claisen reaction to yield the optically active (2R,4S)-beta-campholinic acid. It is also able to cleave 2,2-disubstituted cyclohexa-1,3-diones such as 2-methyl-2-propylcyclohexa-1,3-dione and 2-methyl-2-butylcyclohexa-1,3-dione which result in racemic keto acid products. Transformations of the bicyclic diketone substrates bicyclo[2.2.1]heptane 2,6-dione and bicyclo[2.2.2]octane-2,6-dione yield (S)-keto acid products.
Interaction partners:
Sequence:
MKQLATPFQEYSQKYENIRLERDGGVLLVTVHTEGKSLVWTSTAHDELAYCFHDIACDRENKVVILTGTGPSFCNEIDFTSFNLGTPHDWDEIIFEGQRLLNNLLSIEVPVIAAVNGPVTNHPEIPVMSDIVLAAESATFQDGPHFPSGIVPGDGAHVVWPHVLGSNRGRYFLLTGQELDARTALDYGAVNEVLSEQELLPRAWELARGIAEKPLLARRYARKVLTRQLRRVMEADLSLGLAHEALAAIDLGMESEQ
Protein: Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11) (Q9P6Q0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex (PIC) with RNA polymerase II and the general transcription factors. The essential med11/22 heterodimer specifically functions in promoting stable PIC formation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 27
Sequence:
MTNSDDDLFSEKSTSSDTQQVQNILELEAKIPDILSSAGKCIEAIQLNNSLEDFRKYSKEFLETVEFISTGLRRQALELEKAEVPVVSLQPKKRYASTPLSNLIFDQSSKLM
Protein: Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) (Q96HN2)
Organism: Homo sapiens (Human)
Function: May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A6QLP2, ECO:0000250|UniProtKB:Q68FL4}. Microsome {ECO:0000250|UniProtKB:Q68FL4}. Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1. {ECO:0000250|UniProtKB:Q68FL4}.
Interaction partners:
- Betaine--homocysteine S-methyltransferase 1
- Cystathionine beta-synthase-like protein
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
- Methionine synthase
- Cystathionine gamma-lyase
- S-adenosylhomocysteine hydrolase-like protein 1
- Adenosylhomocysteinase
- Kynurenine--oxoglutarate transaminase 1
- DNA
- DNA
Sequence:
MSVQVVSAAAAAKVPEVELKDLSPSEAESQLGLSTAAVGAMAPPAGGGDPEAPAPAAERPPVPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEALVSPDGTVTEAPRTVKKQIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAASYTDSSDDETSPRDKQQKNSKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY
Protein: Zinc finger E-box binding homeobox 2 (U3KQ51)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM
Protein: Uncharacterized protein (Q57XE6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSDFDNKCQPSLRNNLRSATETLNRLCRATPEQDIGRMLRGNKTTPQYKAAVTPSARENNTYPTRSSPAVATSASRAPGTAGEWANAFRLLQSQVYNCVVELDTERVVRSNNIREVEQTLSGHVGELRAMILQMKKENEYLTGVVRSLQKRVSPHRAGRSIGNGEHTITSAAPPQTMTTVAGMAALTERLEALEDTVARQQRVVGDRNTRLEGNIREMVGNAVNIEVERTRRIAREAARDCTDELVRTHLASIQAVLQSERQHQQKVDSASSDAVREVVQHFRRLEVDVQRRLQEMNSTITVIRQQQQQRESEIQELSVRVAQDVSAVERSVEAARRELQSGIAKNAQANEARAEATQLALEAAVAERAIAASKEVVMHRATIIDAAEAGAKQKEQQEEQRLLRRLEDAQRTNETVQRQQEKLEEQLKGLQSVVQELQQQLVEAVKASNVASADITKWKARIREALTTSEEARTLAQESTACAQKTEDSVREALARSGVQLKRLVADHENGTLLTQQLTEKLEATEARLASTRTVVDDLSERHKNSLLPMTARVETLHRSLQDIFGPKMEEISGSLVELKATVEQLQLNASSRSKSDARQLSDMRREYTTDIQQLKDCLHQQVREWKQECCTSSSTLKAAVDGLSDTVKLQEQSTTRREALHASAAEVAVLSDRVQALEAAREAVEWRVARGGKTSNLATATEGAQQSAGETTVNSSVGEPGAATDSELGNNGEVIYELRHRITAVEQCVRSREDNLQKLVRNDIQKEVGRLEQLVNRMDEENTSRMQLLRVQLSDDVATRCKGMLCEVETPAQRQLQLQVDRLRESLNPAKLIAAIEADVELQNHLSLALQDAFAPRVGTSESFVQMKRRLQKAEDELAEVKVHTREQNERMKIIESNSEKYMWESSNQTQGEGSAGGRSEVGVLLQLLQTSMKQLQEEQAAARRERELLRTTAKVVETAAPAVEVTSGEGPSAGHHCTSADEMVRSDLKTYLEGCINAVEAKVEAAAQSTADTLDVLKQSIEMCVSFFVDEVNASALLNPLFLPIEAGQNKLNVNTVKGLDGVLLFLWQHQCGLQAAVQALQDGSLGTLDLLQHHEEQLALLQPVGPLATHTAAQLERLAVSLGLPLDTDAMDEMEEEVEVEGELIEDDDNDDELMEESEELVEEEEDEAEQPDEEV
Protein: Major facilitator superfamily (MFS) profile domain-containing protein (A0A1D8PJQ4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDSKKASFESNHKELSASSSNEFNEVLEFTVSNYETLQQQKELGSRRSSVHRKSLEAIKKCITGESNYESPETKDYSVHHIYGDLDSDAIEIQRTQTRNLILTKLESRVEDNTNNYSNDNHEHEVECQDTISVIPDTNIEIAQHGKEFDTIDPELITWNGPDDTEDPRNWPINKKIFLLGFVSLYALVAPMSSSMLSPAMTFIAEDFHISSPIIKSMVVSIQILAWAFGPLIIAPLSEHDYIGRKLVLDVSCWMSLFFNLGCAFSQTTAQMMVCRFIGGLFGCVPMNVCAGVISDMFDAQSRNAALAGYSLVPLLGPVIAPVISGFIVDHKQWRWTFYVLCIFNGFVAITATFLFKETYSPTLLKRKAKKLREQTGNVNLHTIYEIADGETKLGKIWLCMVRPIKLLFTHPMIVGLGSFMAFTYGFMYLMIVTFPEIFGNQYGYSKSVTGLMYIPMGIGFIIGVIFWTYMVGNVYERLTSRNNGVAKPEFRLPCLIASSIFIPVGLIWFGWSAQKKLHWIMPGIGSAIFAMGLVCVFQTIQNYLIDMNVRYAASSVAAAALFRSLFGFSFPLFANKMYSALGYGWANTMCAFIGIFLGVPFPIFCYMYGEKIRHWADKRIEKEQSKRDQKNLERLKLKNDSVV