wanglab/gogpt-training-data huggingface dataset:
Protein: GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] (Q4V328)
Organism: Homo sapiens (Human)
Function: Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity).
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:15897011}; Peripheral membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9JHZ4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JHZ4}. Cell projection, axon {ECO:0000250|UniProtKB:Q9JHZ4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JHZ4}. Synapse {ECO:0000250|UniProtKB:Q9JHZ4}. Note=Localizes to recycling endosomal tubules that are emanating from early endosomes. {ECO:0000250|UniProtKB:Q9JHZ4}.
Interaction partners:
- Glutamate receptor-interacting protein 1
- Glutamate receptor-interacting protein 2
- Vacuolar protein sorting-associated protein 41 homolog
- Ras-related protein Rab-4A
- Early endosome antigen 1
- Ral guanine nucleotide dissociation stimulator
Sequence:
MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGLAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPGETS
Protein: Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (Q61532)
Organism: Mus musculus (Mouse)
Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.
Subcellular location: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
Interaction partners:
- MAP kinase-activated protein kinase 5
- G1/S-specific cyclin-D3
- Septin-7
- Neuralized-like protein 4
- Mitogen-activated protein kinase 4
- Kalirin
- Nuclear receptor coactivator 3
- Cyclin-dependent kinase 1
- Exportin-1
- Dual specificity protein phosphatase CDC14A
Sequence:
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYIRNDMTEPHRPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPIHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTSYSAEPCWQYPDHHENKYCDLECSHTCNYKTRSSPYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKRGKSKCERNGLVKAQIALEEASQQLAERERGQGFDFDSFIAGTIQLSAQHQSADVVDKLNDLNSSVSQLELKSLISKSVSREKQEKGRANLAQLGALYQSSWDSQFVSGGEECFLISQFCCEVRKDEHAEKENTYTSYLDKFFSRKEDSEMLETEPVEEGKRGERGREAGLLSGGGEFLLSKQLESIGTPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHKTYSSILKHLN
Protein: DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) (Q5F1R6)
Organism: Homo sapiens (Human)
Function: May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27346687}. Nucleus {ECO:0000269|PubMed:27346687}. Nucleus, nucleolus {ECO:0000269|PubMed:27346687}. Note=Within the nucleus, localizes primarily to the nucleolus. {ECO:0000269|PubMed:27346687}.
Interaction partners:
- 60S ribosomal export protein NMD3
- Ribosome maturation protein SBDS
- Eukaryotic translation initiation factor 6
- Elongation factor-like GTPase 1
- Signal recognition particle subunit SRP54
- Proliferation-associated protein 2G4
- Heat shock 70 kDa protein 4
- Cytoplasmic 60S subunit biogenesis factor ZNF622
Sequence:
MKCHYEALGVRRDASEEELKKAYRKLALKWHPDKNLDNAAEAAEQFKLIQAAYDVLSDPQERAWYDNHREALLKGGFDGEYQDDSLDLLRYFTVTCYSGYGDDEKGFYTVYRNVFEMIAKEELESVLEEEVDDFPTFGDSQSDYDTVVHPFYAYWQSFCTQKNFAWKEEYDTRQASNRWEKRAMEKENKKIRDKARKEKNELVRQLVAFIRKRDKRVQAHRKLVEEQNAEKARKAEEMRRQQKLKQAKLVEQYREQSWMTMANLEKELQEMEARYEKEFGDGSDENEMEEHELKDEEDGKDSDEAEDAELYDDLYCPACDKSFKTEKAMKNHEKSKKHREMVALLKQQLEEEEENFSRPQIDENPLDDNSEEEMEDAPKQKLSKKQKKKKQKPAQNYDDNFNVNGPGEGVKVDPEDTNLNQDSAKELEDSPQENVSVTEIIKPCDDPKSEAKSVPKPKGKKTKDMKKPVRVPAEPQTMSVLISCTTCHSEFPSRNKLFDHLKATGHARAPSSSSLNSATSSQSKKEKRKNR
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Q9BLY4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSIKIEFAVQMRRGDESYAGALRSALDGVGQVEIDTQEGRVIIQTQRPWSEIQDKIEATGVRAVLSGFGGQSAVALINTTGSVVDKTPIQGVVRFTTITADKKPGVVVDGVVDGLSPGLHGLHIHESGDTSAGCSSVGEHYNPRQSPHGSPAAGAEERHAGDLGNIRADENGRATFRFVDPVLEVWDIIGRAVVLTANADDLGRGGNDQSLIDGNSGERIACGIIARSAGILENFKRICACDGVTLWDERNKPLAGKDRSQKL
Protein: Dual endothelin-1/VEGF signal peptide receptor (DEspR protein) (Dual endothelin-1/VEGFsp receptor) (Dual endothelin-1/angiotensin-2 receptor) (Dear protein) (FBXW7 antisense RNA 1 homolog) (D3ZGZ6)
Organism: Rattus norvegicus (Rat)
Function: Dual endothelin-1/angiotensin-2 receptor that is functionally coupled to a calcium-mobilizing transduction system, responding equivalently to both endothelin-1/EDN1 and angiotensin-2 peptides in a highly specific manner. Also binds the signal peptide of VEGFA (By similarity). May play a role in angiogenesis with a significant role in cardiovascular and neural development (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:9508787}; Single-pass membrane protein {ECO:0000250|UniProtKB:B0L3A2, ECO:0000255}.
Interaction partners:
Sequence:
MSTFYVTAVPKSHSSLPKCQAMMSRTLLTGMAMYLDSSHAGAASMQVSWPPLLTSLGSKEMKSRWNWGSITCIMCFTCVGSQLSMSSSKASNFSGPLQLYQRGIGHITNPYRRPPAPAWPCSSSGTT
Protein: Rubisco methyltransferase family protein (Q8VZB5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- ETFB lysine methyltransferase
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Chaperonin 60 subunit beta
- Calmodulin-lysine N-methyltransferase
- Protein arginine N-methyltransferase 1.6
Sequence:
MEGVITCFHTKCVSLPIRSFPLSRVSSLPRWRNNKLISSSRSVHLRSLCVSSSDTLVASGSPKEDERQSKVSSKKEGDDSEDLKFWMDKNGLPPCKVILKERPAHDQKHKPIHYVAASEDLQKGDVAFSVPDSLVVTLERVLGNETIAELLTTNKLSELACLALYLMYEKKQGKKSVWYPYIRELDRQRGRGQLDAESPLLWSEAELDYLTGSPTKAEVLERAEGIKREYNELDTVWFMAGSLFQQYPFDIPTEAFSFEIFKQAFVAIQSCVVHLQNVGLARRFALVPLGPPLLAYCSNCKAMLTAVDGAVELVVDRPYKAGDPIVVWCGPQPNAKLLLNYGFVDEDNPYDRVIVEAALNTEDPQYQDKRMVAQRNGKLSQQVFQVRVGKEREAVQDMLPYLRLGYMSDPSEMQSVISSQGPVCPMSPCMERAVLDQLANYFMRRLSGYPTTPKEDDALLADPSLSPRKRVATRLVQLEKKILVACLTTTVDLLNQLPDTAISPCPAPYAPSLK
Protein: Cell surface superoxide dismutase [Cu-Zn] 4 (EC 1.15.1.1) (GPI-anchored protein 2) (Q5AD05)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:15302828}. Membrane {ECO:0000305|PubMed:15302828}; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP). {ECO:0000269|PubMed:15302828}.
Interaction partners:
- Superoxide dismutase 1 copper chaperone
- Peroxisomal catalase
Sequence:
MKYLSIISIVALALAGDSPISTDSKGKAPLVARFKKTSKSDIEGTIKFEPANNGTVLVSVDLTGLPSGVGPYPYHVHEKPVPESKNCTATGMHFNPFNGSTTAKTPAALELGDLSGRHGNITSESFEVEYDDSYISLNKDSKAYIGGLSIVVHSNNNTRLNCANITTLDEGDDTASAATWSNSSSSSSSSSKNSTNGSSGSSTSASQGSGAGRAEISGFLAAGIAGVVAALI
Protein: Candida glabrata strain CBS138 chromosome M complete sequence (Q6FJR5)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
Sequence:
MKFSSLCMLASVAAHSKAAKNVADLSYVKLDFDKYYGETFETAKRGRSQADIRVNKRANGYEEVQITNQNSFYSVTLEVGTPPQSVVVLVDTGSSDLWITGSDNPYCRGSTGTSGKNMLLEAELKRALEDARDIAKERTTLAPRDDEHNDGLLSWLTGSDGLLGGQGGTTITLTDSAQPTAAGTSNGARATINCAKYGTFDTSKSSTWHSNDTAFMIQYGDSTFASGTWGMDNLHLSDLNVTGLSFAVANRTNSTVGVLGIGLPALEVTYSGRTAVSGQRPYQYDNFPLVLLRNGAIKSNSYSLFLNNASAETGSVLFGAVDHSKYLGDLYTIPMVNTYASQGYKNPIQFEVTLNGLGISSSSDNTTITTTKIPALLDSGTTLTYLPQALVTRIVQKLQATYSNRAGYYVFSCPSQSDDTEVVFDFGGFHINAPITNFIIGSSGDSCILGIMPQSGGGIILGDSFLNSAYVVYDLENYEISMAQANYAGGQEDIEVISSSVPGAVRAPGFSSTWSTLATSFNTQGDIFTVQAAATVSGSATNTGTGRATATGNSNSTRSTTSRSRTSATSTRSDSQKKNDASRTSFTSTLLFVAGLLVSFI
Protein: Tox-GHH domain-containing protein (Q8I7J1)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRKSEVTWGSWKIRLTYDNSNRLTEHAIDGARVPIKMSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIALGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHYWLERKDPITGRTTEILNDEETTVVTCWSPEGAPMCSRSRNLQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARDASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARASIKIIRDKAGRASESHLEISSSGTQRNQKITRTFDAAGRVASVEQNDQEPVRIIWNSDARVEKINDRVVEWNRGGALKTFQDISYQVDSIGWVVKRDNTTVFGYDGKGRLVSARSSQLRINIFYDREDRVVQIQNSKDFIHFYYGYIDTPKLVSHFSKNGKISTLFYDDDSVPFAMQSDDGTRYALLTDETSTIKAIIGDSNVLRIIDRSVFGALLPSSSSSHPFLPIGYLGGIEISEISVSILNNGRPLDLYSERYMSISPEAVVRLELNEKFSNSIDLMALEIDRQPFRVENVPEDFETWFSLAGLSPNLLPSAHLGLPASSAIVHRLLSSFPRKLRPLTHLTTVLPTRLASDISLTSPTSETSWSIDDVGFSNLLILNEDATTGEVMVEMLSDLKSEEREVISKLFDGVKSLDFATWGLVPTRHLWRAPNSKLELSSTSFSHFTMAVNKDSVELRNGKSKIVVHFSENKAEIVKKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRLVICKIS
Protein: Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) (Q93088)
Organism: Homo sapiens (Human)
Function: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O09171}. Nucleus {ECO:0000250|UniProtKB:O09171}. Note=Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. {ECO:0000250|UniProtKB:O09171}.
Interaction partners:
- Dimethylglycine dehydrogenase, mitochondrial
- Cystathionine gamma-lyase
- Adenosylhomocysteinase
- S-adenosylmethionine synthase isoform type-1
- Cystathionine beta-synthase-like protein
- S-adenosylmethionine synthase isoform type-2
- Methylenetetrahydrofolate reductase
- Adenosylhomocysteinase 3
- S-adenosylhomocysteine hydrolase-like protein 1
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
Sequence:
MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ
Protein: GTPase Der (GTP-binding protein EngA) (B5X565)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- GTP binding protein-like
- Glucose-inhibited division family A protein
- Short integuments 2, mitochondrial
- At4g38020 family protein)
- Large ribosomal subunit protein uL24c
- Pseudouridine synthase family protein
- Large ribosomal subunit protein uL29m
- Protein Iojap-related
- Large ribosomal subunit protein mL43
- Protein disulfide-isomerase 5-4
Sequence:
MASLLDSLTTRGFFTMPSISRIYSPLASSTSLTSSPSSSSSIIPSLSVLSYTHQHPHSSRFPFLVAATLDGSSAEEELDFEEFDQYAEDNFADDYSDDEDDSIDISVLEKEARDIVRDYATTLSRELKIEDETIEGKETRRKGKRLAKNTQQIPEHLLQRVAIVGRPNVGKSALFNRLVGENRAIVVDEPGVTRDRLYGRSYWGDQEFVVVDTGGVMTVSKSPSGVMEELNVSTTIGMEGIPLSSREAAIARMPSMIEKQATAAVDESAVIIFVVDGQAGPSGADVEIADWLRKYYSHKYIILAVNKCESPRKGLMQASEFWSLGFTPIPISALSGTGTGELLDLVCSGLIKLEIMENIEEEEEENYIPAIAIIGRPNVGKSSILNALVREDRTIVSPVSGTTRDAIDAEFTGPDGEKFRLIDTAGIRKKSSVASSGSTTEAMSVNRAFRAIRRSDVVALVIEAMACITEQDLKIAERIEREGKGCLVVVNKWDTIPNKNQETAAHYEDDVREKLRSLKWAPIVYSTAITGHSVDNIVVAAATVQKERSRRLSTAILNQVIREAVAFKSPPRTRGGKRGRVYYCTQAAIRPPTFVFFVNDAKLFSDTYRRYMEKQLRTDAGFAGTPIRLLWRSRKRSDKNGGGGGTMRMAGLTRQRNLATKRT
Protein: Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) (Q6ZNE5)
Organism: Homo sapiens (Human)
Function: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion. Modulates the hepatic lipid metabolism (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:37632749}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597}; Peripheral membrane protein {ECO:0000305}. Preautophagosomal structure membrane {ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:22314358}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:25686604}; Peripheral membrane protein {ECO:0000305}. Note=Cytosolic under nutrient-rich conditions (PubMed:19050071). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:19050071). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3}.
Interaction partners:
- RB1-inducible coiled-coil protein 1
- Synaptosomal-associated protein 29
- Beclin-2
- Syntaxin-17
- Phosphoinositide 3-kinase regulatory subunit 4
- Nuclear receptor-binding factor 2
- Serine/threonine-protein kinase ULK1
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- UV radiation resistance-associated gene protein
- Beclin-1
Sequence:
MASPSGKGARALEAPGCGPRPLARDLVDSVDDAEGLYVAVERCPLCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSRLKSKQEEFQKEVLKAMEGKWITDQLRWKIMSCKMRIEQLKQTICKGNEEMEKNSEGLLKTKEKNQKLYSRAQRHQEKKEKIQRHNRKLGDLVEKKTIDLRSHYERLANLRRSHILELTSVIFPIEEVKTGVRDPADVSSESDSAMTSSTVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDYSAYYSWVEEKKTTQGPDMEQSNPAYTISAALCYATQLVNILSHILDVNLPKKLCNSEFCGENLSKQKFTRAVKKLNANILYLCFSQHVNLDQLQPLHTLRNLMYLVSPSSEHLGRSGPFEVRADLEESMEFVDPGVAGESDESGDERVSDEETDLGTDWENLPSPRFCDIPSQSVEVSQSQSTQASPPIASSSAGGMISSAAASVTSWFKAYTGHR
Protein: B30.2/SPRY domain-containing protein (Q382D2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGLEIFEIDTSTPHTGVVIDGTTACREANSGWVTLRAKTPLSAGQCQWAMKVIDQGEGNDGSGLMMGLLPRLNSQQEVAMGSKYISELGGWCLSRAGDSYGCWKCDKMPFSTGCVVEFDWDAASRTLYIVSGKRKASGHIPNVSEADVVYPAFSMFYLNQKLAFV
Protein: Ribitol-5-phosphate transferase (Q4KLJ4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Ribitol-5-phosphate transferase
- Ribitol xylosyltransferase 1
- Protein O-mannosyl-transferase 1
- Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
- Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
- Protein O-mannose kinase
- Dolichyl-phosphate-mannose--protein mannosyltransferase
- D-ribitol-5-phosphate cytidylyltransferase
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- Amyloid beta precursor like protein 1
Sequence:
MRLTRCWAALAAAIILNLLVFFYVSWLQHQPRNSRTRGPRRTSAIGPRVTVLIREFEAFDNAVPELVDSFLQLDPAQPVVVAADTLPYPPLALPRIPNVRLALLQPALDRSAAASRPETYVATEFVALVPDGARAESPGHLERMVEALRGSSARLVAAPVATTNPARCLALNVSLREWTARYGPAPSAPRCDALDGDAVLLMRSRDLFNLSVPLARPLATSLFLQTALRGWAVQLLDLTFASARQPPLATAHARWKAEREGRSRRAALLRSLGIRLVSWEGGRLEWFGCSKESPRCFGTVVGDTPAYLYEGRWTPPCCLRALRETARYVVGVLEAAGVRYWLEGGSLLGAARHGDIIPWDYDVDLGIYLEDVGNCEQLRGAEAGSVVDERGFVWEKAVEGDFFRVQYSESNHLHVDLWPFYPRNGVMTKDTWLDHRQDVEFPEHFLQPLVPLAFAGFMAQAPNNYRRFLELKFGPGVIENPEYPNPALLSLTGG
Protein: Uncharacterized protein, isoform A (Q9VFA3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- FI24038p1
Sequence:
MHRRCIICGQEPGEQCVYPRNMSEARRWQNLANLSSFDVDPESLCRHGCVCASHLDGHGSGSESESSSRAAGRARTQAGLQEWSRWSSSASDAGHGYSISKKTNERIQNQSKQSLGSERQEFSSANRCTNGCCRFRNTCNSMFQGNTYTQMGQKYPNPQTRATNLENKNNPPMKLSPRVNKPTFGAVNCTCDGCTCSFCPVQGIKKAVAPLEEDSGSQQSINKEYKERKDNSKGSPKKQSSCERLTCPAFRTTDIKTVADDFRSSPNYPVSPTSRGNNKIKSSMNQQNTKKKPELKSECCQTCITQQLKDQEVQCSTVTLQTQSSSPVRRTKMTGSFSHQTGSSATGLSGGYTNNSNNFTCGGGERRTSNAINVLLMNGTRNNDYEDGCCSPAKQRPMAPPPEICVQESDLTENDERAVFPEIDKPNYRVCRSSNETNVLVLEESPLNDCSPNPGQDASTLDSKTKSNFDAQQNANDNKEQHNSFLINWLESPATSNFTKVLELQRSRIKELENLLEQHSLLQQTIQHKVAELQCTDIPDPKNISKS
Protein: Lysine demethylase 5B (A0A3B3IT85)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRKPNLTTDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMNIKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTF
Protein: Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (A0A8I5ZNT3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
RCTGIWKMLVAAVCLALLGCLQAQEFRGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHSFSFHGAALTAPQQGQKLMDKALESLSCPKDLVPSRCDELKAQFLQLSQYRQLKTVEDYQTLNKDIETQVQQDGLWEAGRVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGVIRDTLQNHLTEILTLVAMELPPNISSSAAVLQHKLQAFQALRGLQKSNAILGQYQAYSGQVRQELQKPDGFQSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNRAYCTQGERHWVPERSRCLPQQIVFYIGHGELGHPAILVSKNLFKPSLPAQSWKGVQDQPGLHLFGRPLSDYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLSFEVPRLYPGGAENDHLLDFEFSGGQLTFSQQQLEVLMPELGSVPKPSDFQVLRAQYRKSPLITAWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGHYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQAHLLQHVRVPYYNIHPMPVHLHQRLCAEEDQGAQTYASEISALVANSSFDLVLLGMGTDGHTASLFPQSPRGLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPLSGQLVWYMDYEAFLG
Protein: M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) (P30307)
Organism: Homo sapiens (Human)
Function: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:8119945}.
Interaction partners:
- 14-3-3 protein epsilon
- Serine/threonine-protein kinase Chk1
- 14-3-3 protein zeta/delta
- Serine/threonine-protein kinase PLK1
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase Chk2
- 14-3-3 protein beta/alpha
- Cyclin-dependent kinase 2
- G2/mitotic-specific cyclin-B2
- 14-3-3 protein theta
Sequence:
MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNPNLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
Protein: Protein myomaker (Myoblast fusion maker) (Transmembrane protein 226) (Transmembrane protein 8C) (A6NI61)
Organism: Homo sapiens (Human)
Function: Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX. Acts independently of MYMX (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9D1N4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9D1N4}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D1N4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9D1N4}. Note=Localizes on the plasma membrane of myoblasts, where it mediates myoblasts fusion. Also localizes in the Golgi apparatus and post-Golgi following palmitoylation; the role of Golgi localization is unclear. {ECO:0000250|UniProtKB:Q9D1N4}.
Interaction partners:
- Protein myomixer
- Myogenin
- Myoblast determination protein 1
Sequence:
MGTLVAKLLLPTLSSLAFLPTVSIAAKRRFHMEAMVYLFTLFFVALHHACNGPGLSVLCFMRHDILEYFSVYGTALSMWVSLMALADFDEPKRSTFVMFGVLTIAVRIYHDRWGYGVYSGPIGTAILIIAAKWLQKMKEKKGLYPDKSVYTQQIGPGLCFGALALMLRFFFEDWDYTYVHSFYHCALAMSFVLLLPKVNKKAGSPGTPAKLDCSTLCCACV
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q8MSQ7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKKILSKFERNENSRLENPPNSSSSSSSNEKNSFVGKVFTVGRVTVTVEDVLAEGGFAMVFLARGNGGGSSSATKYALKRMYVNNEHDLNVAKREIQIASNLSGHKNIIGYVDSSITPTGNGVCEVLLLMPYCKHHMLAMMNARLHVGFTEPEVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENILQTDAGNFVLCDFGSATAKTLNPQQHGVTVVQEEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCFFSLPFGESTLAIQNGQFSIPDSSKYSKGMHQLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDNPVQNLHKTPIPNFDLLVVPPFESEAKRISAAASKAAKAQNVSVVEAGTSVVPRSRPKGSSSVHGGNPLGLGLPLSPSPRQNITSPQPQPQPVVEQFQANFPAMPPAVPPPPQAVTPAAPAASKLFESSGYPDPFNEPAAAVIPTEFLPAAEEPNKEEVPQDLNVIAGTPTKSMLTPPKPSGGGGHRRNVSDTSTFNKTFANETSQFLAPFNNNLAAMGDGQQTLASAASNPGIYASSTANSAAVSISELMKPGQTAVEKRVEAWNPFEEEQPFSQMTEDHIFEAEFDKIRQRGSQGSITAKSASTTSTLTPTEQIPSAVVAPVTAAPGAVPPPPIAAAVSPHPSQVSEDPFGSAPFSLPPGLREKASSLRKTGGKA