wanglab/gogpt-training-data huggingface dataset:
Protein: Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: CCB peptide; PE-11] (P16014)
Organism: Mus musculus (Mouse)
Function: Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Subcellular location: Secreted. Note=Neuroendocrine and endocrine secretory granules.
Interaction partners:
- Chromogranin-A
- Secretogranin-2
- Secretogranin-3
- Neuroendocrine protein 7B2
- Synaptosomal-associated protein 25
- ProSAAS
- Pro-neuropeptide Y
Sequence:
MQPAMLLGLLGAAALAAVSSAPVDNRDHNEEMVTRCIIEVLSNALSKSSVPTITPECRQVLKKSGKEVKGEEKGENQNSKFEVRLLRDPADASGTRWASSREDAGAPVEDSQGQTKVGNEKWTEGGGHSREGVDDQESLRPSNQQASKEAKIYHSEERVGKEREKEEGKIYPMGEHREDAGEEKKHIEDSGEKPNTFSNKRSEASAKKKDESVARADAHSMELEEKTHSREQSSQESGEETRRQEKPQELTDQDQSQEESQEGEEGEEGEEGEEGEEDSASEVTKRRPRHHHGRSGSNKSSYEGHPLSEERRPSPKESKEADVATVRLGEKRSHHLAHYRASEEEPEYGEESRSYRGLQYRGRGSEEDRAPRPRSEESQEREYKRNHPDSELESTANRHGEETEEERSYEGANGRQHRGRGREPGAHSALDTREEKRLLDEGHYPVRESPIDTAKRYPQSKWQEQEKNYLNYGEEGDQGRWWQQEEQLGPEESREEVRFPDRQYEPYPITEKRKRLGALFNPYFDPLQWKNSDFEKRGNPDDSFLEDEGEDRNGVTLTEKNSFPEYNYDWWERRPFSEDVNWGYEKRSFARAPQLDLKRQYDGVAELDQLLHYRKKADEFPDFYDSEEQMGPHQEANDEKARADQRVLTAEEKKELENLAAMDLELQKIAEKFSQRG
Protein: LD06441p (Mitochondrial ribosomal protein S35) (Q9VZX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein uS5m
- Mitochondrial ribosomal protein S11
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein bS6m
- Small ribosomal subunit protein uS12m
Sequence:
MSSALTRLLERLPLKKQTAQSGIRVFSNQEQRQEIEDDEEFRVLSLRTVKQQMQKRQQVRRDPITPPRTGRMAVDQDWTAVWPGPRSFHPASVPLPLRQGFTERGAAAPSKFANAELMKIPNFLHLTPPAIRQQCEAIKKFCTPWPKGLETEAKWQRHFPLEVTTTDYCQSLPTIRNPEARRVTITLKLSDLKFDAHARDKFLRLVGDRYNKDTDLVTFVTDRCPQKKQNYDYALYLLTACYHESFVTEPWEATKSEADMEVYLFERNQSKVSAEGILNWNAKKGAPKVVPSKSFAECVEKLINEGENEYNLGKYKEEVKKMLNIA
Protein: Heme Responsive protein (Q20983)
Organism: Caenorhabditis elegans
Interaction partners:
- Cadmium-inducible lysosomal protein CDR-5
- Heme transporter hrg-4
- Heme transporter hrg-1
- Neuropeptide
- MSP domain-containing protein
- Uncharacterized protein
- FIP
- TransThyretin-Related family domain
- Late embryogenesis abundant protein D-29-like
- C-type lectin domain-containing protein
Sequence:
MVNFTRSCSLLIILLFIFLISNVELRPVMKSGYSKNHHLFRPKNLQTDSEEGFWNNVYFVITASDSFFGG
Protein: Histone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.B) (H2A.Bbd) (P0C5Y9)
Organism: Homo sapiens (Human)
Function: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:20008104, ECO:0000269|PubMed:24336483}. Chromosome {ECO:0000269|PubMed:20008104, ECO:0000269|PubMed:22795134, ECO:0000269|PubMed:24336483}. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies. {ECO:0000269|PubMed:20008104}.
Interaction partners:
- Histone H2B type 2-E
- Histone H3-like centromeric protein A
- Histone H2B type 1-A
- Histone H3.1t
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- Histone deacetylase 2
Sequence:
MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVIEYLTAKVPELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQVAPGED
Protein: Kinesin family member 21A (A0A1B0GV47)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, growth cone {ECO:0000256|ARBA:ARBA00004624}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
VRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKSIEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRDIDAKSKKSNIRIHEDSTGGIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDADNATDNKIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIPVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLKQREELTKRREKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQANIMQMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSVPLENVEDSTDEDAPLNSPGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSELASDTSTGDASLPGPLTPVAEGQEIGMNTETSGTSAREKELSPPPGLPSKIGSISRQSSLSEKKIPEPSPVTRRKAYEKAEKSKAKEQKHSDSGTSEASLSPPSSPPSRPRNELNVFNRLTVSQGNTSVQQDKSDESDSSLSEVHSRSSRRGIINPFPASKGIRAFPLQCIHIAEGHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQEIMSLGGHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRDSAKCIRTLTSSGQVTLGDACSASTSRTVAIPSGENQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISSGQDLIITGSKDHYIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLTQKDLLQQVPNAHKDWVCALGVVPDHPVLLSGCRGGILKVWNMDTFMPVGEMKGHDSPINAICVNSTHIFTAADDRTVRIWKARNLQDGQISDTGDLGEDIASN
Protein: Protein BEX5 (Brain-expressed X-linked protein 5) (NGFRAP1-like protein 1) (Nerve growth factor receptor-associated protein 2) (Q5H9J7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15958283}.
Interaction partners:
- Transcription elongation factor A protein-like 2
- Transcription elongation factor A protein-like 3
Sequence:
MENVPKENKVVEKAPVQNEAPALGGGEYQEPGGNVKGVWAPPAPGFGEDVPNRLVDNIDMIDGDGDDMERFMEEMRELRRKIRELQLRYSLRILIGDPPHHDHHDEFCLMP
Protein: RGG repeats nuclear RNA binding protein A (Q9SQ56)
Organism: Nicotiana tabacum (Common tobacco)
Function: Binds RNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:11905967}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O23523}.
Interaction partners:
- 40S ribosomal protein S25
- 40S ribosomal protein S25
- 60S ribosomal protein L29
- 60S ribosomal protein L29
- 40S ribosomal protein S28-like
- 40S ribosomal protein S28
- 60S ribosomal protein L38
- 60S ribosomal protein L38
- 40S ribosomal protein S29
- 40S ribosomal protein S29-like
Sequence:
RGGGRGGPRGGGRGRGPGRGRGFNQESADDENAFGSNNGFSGRYRVQEDGESGKLSERRGGYGGPRGGFHGGRRGGFNNGDAAEGEGERPRRVFDRRSGTGRGNEYIKREGSGRGNWGTPADDIAQETEVPVNDGEKIVEAEKEAGQEEAEDTNKDSTAAEPEEKEPEEKEMTLEEYEKLMEEKRKALLALKPEERKVNLDKELESMQLLSNKKNDDEIFIKLGSEKEKRKEAVEKARKTQSINEFLKPAEGENYSRRGGRGRGPGRGRGGFGGGVGGNKSFSAPSIEDVGQFPSLVAK
Protein: Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16) (Q91WF7)
Organism: Mus musculus (Mouse)
Function: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:19037259}. Note=Localization requires VAC14 and PIKFYVE. {ECO:0000269|PubMed:19037259}.
Interaction partners:
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Protein VAC14 homolog
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- Myotubularin
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Phosphatidylinositol-3-phosphate phosphatase MTMR1
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14
- Phosphatidylinositol-3-phosphate phosphatase MTMR7
- Inositol polyphosphate-4-phosphatase type I A
Sequence:
MPTAAAPIISSVQKLVLYETRARYFLVGSNHAETKYRVLKIDRTEPKDLVVIDDRHVYTQQEVRELLGRLDLGNRTKMSQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIPNDSVRISHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSETSKACQESFDIFEDEGLITQGGSGVFGISSEPYMKYVWNGELLDIIKNTVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLFWSQDISTMMPKPPITLDQADPFAHVAALHFDQMLQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGHVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMSLLPPRRSYTYWWTPEVVKHLPLPYDEVICAANLKKLMVKKFHRWEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTVGIDPSPFTVRKPDETGKSVLGNKNTREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREDEGSISQRSTPVKMTDTGDSAKATENVVQPMKEVYGVSLSSSLSEEDHSIYARFVQLGQSQHKQDRGNQQLCSRCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDTAMYREYIRNRYL
Protein: AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Clathrin assembly protein assembly protein complex 3 mu-1 medium chain) (Clathrin coat assembly protein AP47 homolog 1) (Clathrin coat-associated protein AP47 homolog 1) (Golgi adaptor AP-1 47 kDa protein homolog 1) (HA1 47 kDa subunit homolog 1) (Mu-adaptin 3A) (Mu3A-adaptin) (P47A) (P53676)
Organism: Rattus norvegicus (Rat)
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).
Subcellular location: Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Interaction partners:
- AP-3 complex subunit delta-1
- AP-3 complex subunit beta
- AP-3 complex subunit beta.
- AP complex subunit sigma
- Adaptor related protein complex 3 subunit sigma 1
- AP-3 complex subunit mu-2
- AP-2 complex subunit alpha
- AP-1 complex subunit gamma
- AP-4 complex subunit epsilon
- Arpin
Sequence:
MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPTVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHNISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLAWDVGKITPQKLPSLKGLVNLQSGAPKPEENPNLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYITKAGKFQVRT
Protein: Chaperone protein dnaJ 20, chloroplastic (AtDjC20) (AtJ20) (Q9SDN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a continuous role in plant development probably in the structural organization of compartments.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Chaperone protein dnaJ 8, chloroplastic
- Heat shock 70 kDa protein 4
- Heat shock 70 kDa protein 17
- Heat shock 70 kDa protein 7, chloroplastic
- Chaperone protein dnaJ 50
- Heat shock 70 kDa protein 5
- Heat shock 70 kDa protein 1
- Heat shock 70 kDa protein BIP2
- Heat shock 70 kDa protein 6, chloroplastic
- Heat shock 70 kDa protein 18
Sequence:
MKCYKSSSILSTNHHPFFYKQQPISSLQPTSIPTTISYPTRTRFSSTRIQSRLTHDDPVKQSEDLSFYDLLGVTESVTLPEIKQAYKQLARKYHPDVSPPDRVEEYTDRFIRVQEAYETLSDPRRRVLYDRDLSMGFSFSFSGRRQNRYDQEVVEEKSEWKAKWQTQLSGLRRRSNQKDNNTMSWAARMRRQQQESS
Protein: RE59368p (Q8IGN0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004159}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004159}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004159}.
Interaction partners:
Sequence:
MFSFLKREKNTQEVVENVIGELKKIYRSKLLPLEEHYQFHDFHSPKLEDPDFDAKPMILLVGQYSTGKTTFIRYLLERDFPGIRIGPEPTTDRFIAVMYDDKEGVVPGNALVVDPKKQFRPLSKYGNAFLNRFQCSSVASPVLNAISIVDTPGILSGEKQRIDRGYDFTGVLEWFAERVDRIILLFDAHKLDISDEFRRSIEALKGHDDKIRIILNKADMIDHQQLMRVYGALMWSLGKVLQTPEVARVYIGSFWDQPLRFDANRRLFEDEEQDLFRDLQSLPRNAALRKLNDLIKRARLAKVHAFIIAELRKDMPSVFGKDSKKKDLIKNLGQVYDRIQREHSISPGDFPDIKKMQEVLQHQDFTKFHSLKPHLLDIVDNMLAKDIARLMEMIPQEEMTMVADPMVKGGAFEGVIDDHVSPFGYMKGEGIDAGYGEHEWICNKDKPRTDGIFNGLGPVDGKISGATAKQELIKSKLPNSVLSKIWKLSDVDGDGFLDSDEFALALHLINVKLEGCELPTVLPEHLVPPSKRYD
Protein: DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) (Q6IQ26)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6PAL8}.
Interaction partners:
- Ras-related protein Rab-6A
- Ras-related protein Rab-11A
- Sorting nexin-1
Sequence:
MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLETSLVKGIDI
Protein: Potassium voltage-gated channel subfamily E member 2 (MinK-related peptide 1) (MiRP1) (Minimum potassium ion channel-related peptide 1) (Potassium channel subunit beta MiRP1) (Q9Y6J6)
Organism: Homo sapiens (Human)
Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current. KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20533308}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P63161}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D808}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with KCNB1 at the plasma membrane. {ECO:0000250|UniProtKB:P63161}.
Interaction partners:
- Potassium voltage-gated channel subfamily KQT member 1
- Voltage-gated inwardly rectifying potassium channel KCNH2
- Sodium channel protein type 5 subunit alpha
- Potassium voltage-gated channel subfamily E member 3
- A-kinase anchor protein 9
- Inward rectifier potassium channel 2
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Potassium voltage-gated channel subfamily E member 4
- Sodium channel regulatory subunit beta-4
- Potassium voltage-gated channel subfamily A member 5
Sequence:
MSTLSNFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEESKATIHENIGAAGFKMSP
Protein: Uncharacterized protein (Q57UT7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSEEHANDSTLRVKVATINDKGEEVYASSLSHDGTYLAAVFGDGALVIFNPSTFSALDSSAAGKGYDNVPCTAVQWLESSEGGLYRLVSVSSAGGVFIWQWDGAALHRTNRVPEKGNEITCLAVSPECDMFITAGSDRTVRLYDADGTLKANLQMAHDESGVSRLAHTSRIFSVRFVSQGVAVSGGWGGPLQVWDLKANEARVEIRGAQVSSDGIELITGTNCVLVASRRQKEQLQVFDCVSGQELADDSARLSMALGELIPLSSRLCKTSGLVWTITSSPSKVLVTSYSTGQLIASYDSAYDLMNISIFEGLPNNAYISCAEGKLLFATVKQ
Protein: Nuclear hormone receptor family member nhr-8 (Q9XYB7)
Organism: Caenorhabditis elegans
Function: Orphan nuclear receptor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Nuclear receptor corepressor 1
- Cholesterol 7-desaturase
- 3-ketosteroid oxygenase
Sequence:
MPSSSPSMDESRRSAVPPKEPAGRICTVCSDRANGYNFGVLTCESCKAFFRRNASKHKEIKCPFSDSCQITSASRKFCQACRLNKCFAVGMNSEWLNDLKPKSSIVSGKFKRKKPDMKNNLKVEVDDTEEDLENDDEEQISVPKALLEKLINKANEKSKDRCTCKCQCGFYPITQRLTAYEPKDTTAVNSPQDISFSHHLHHSDSFYSSSTSTLSPMSVISCAPSSHDSSGYNTSQLVTQSPTNYTVSPASIPSSITELSPQMPSQYPPMLSPFQFGVMAQMAAPANFLNFPPMPERTWTPIQAVSTVPVTETLPPNLLEQIHSKIDKYIGVLNEDEITLLEELHVQNEPLNAPLIQWHNPKSIDGVFRIIEEALRRIVNMACQLSLFRELHVDDRKNLLKSGFGELLIVRGLMAYDKSDNSWNHSFGVRGKMEVKVEVLKNPKLEEHYKAHMNLLSTFGEDVRNNEHLMLIFNAAVIFHPHVSNLRDSKRVHSTQAKYFQMLLKLLTFEYGKSRADIAYSNLLNQVVELHRVNRTLLRVFYGLDIAQLDPLIRELCSFE
Protein: Chromosome 17 open reading frame 49 (F8W1H0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQLHPVADSSPAGAKWTETEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKATVKRKVYEDSGIPLPAESPKKGPKKVASGVLSPPPAAPPPSSSSVPEAGGPPIKKQKADVTLSALNDSDANSDVVDIEGLGETPPAKKLNFDQDSLTLDSGLLMTSADPPLLSC
Protein: Lysine--tRNA ligase, chloroplastic/mitochondrial (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) (Lysyl-tRNA synthetase 2) (AtKRS-2) (Protein OVULE ABORTION 5) (Q9LJE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:16251277}. Mitochondrion {ECO:0000269|PubMed:16251277}.
Interaction partners:
- Methionine--tRNA ligase, cytoplasmic
- Leucine--tRNA ligase, cytoplasmic
- Leucine--tRNA ligase, chloroplastic/mitochondrial
- Glutamate--tRNA ligase, cytoplasmic
- Isoleucine--tRNA ligase, chloroplastic/mitochondrial
- Isoleucine--tRNA ligase, cytoplasmic
- Proline--tRNA ligase, cytoplasmic
- Proline--tRNA ligase, chloroplastic/mitochondrial
- Arginine--tRNA ligase, chloroplastic/mitochondrial
- Arginine--tRNA ligase, cytoplasmic
Sequence:
MEALKVWSLTATPLKQLLRLSSSSTRLATTIYGRRSYHLSPALRCASAASSSSSSATTAETSKPSGRNRRSASSSNSTSDREAIRSIRLKKVEELRGQGLEPYAYKWEKSHSANQLQEIYKHLANGEESDNEIDCVSIAGRVVARRAFGKLAFLTLRDDSGTIQLYCEKERLSDDQFEQLKQFIDIGDILGASGSMKRTEKGELSICVNSFSILTKSLLPLPDKYHGLTDIDKRYRQRYVDMIANPEVADVFRRRAKIVSEIRKTVESFGYLEVETPVLQGAAGGAEARPFVTFHNSLGRDLYLRIATELHLKRMLVGGFEKVYEIGRIFRNEGISTRHNPEFTTIEMYEAYSDYHSMMDMAELIVTQCSMAVNGKLTIDYQGTEICLERPWRRETMHNLVKEITGINFSELGEDLGNAKDTVLLALQDVLEPKDKSGIRACSSLGHLLNEIFEVVVEPKLVQPTFVLDYPIEISPLAKPHRGNAGLTERFELFICGREMANAFSELTDPVDQRTRLEEQVRQHNAKRAEAVRESPEPNAKKDDDDDESYEVTLDEDFLTALEYGMPPASGMGLGIDRLVMLLTNSASIRDVIAFPVLKLQQ
Protein: Probable beta-1,4-xylosyltransferase IRX10 (EC 2.4.2.-) (Glucuronoxylan glucuronosyltransferase 1) (AtGUT1) (Glucuronoxylan glucuronosyltransferase 2) (Protein IRREGULAR XYLEM 10) (Xylan xylosyltransferase IRX10) (Q9FZJ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Probably involved in the elongation of glucuronoxylan xylosyl backbone, especially in the formation of GlcUA side chain of xylans.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ZUV3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9ZUV3}.
Interaction partners:
- Beta-1,4-xylosyltransferase IRX14
- Beta-1,4-xylosyltransferase IRX9
- Probable beta-1,4-xylosyltransferase IRX14H
- Probable galacturonosyltransferase 12
- Probable beta-1,4-xylosyltransferase IRX9H
- Probable galacturonosyltransferase-like 1
- Protein IRREGULAR XYLEM 15
- UDP-glucuronate:xylan alpha-glucuronosyltransferase 1
- Protein IRX15-LIKE
- UDP-glucuronate:xylan alpha-glucuronosyltransferase 2
Sequence:
MKIHSCLSAILLFLFFSASSAKQNVRTERISGSAGDVLEDDPVGKLKVYVYELPSKYNKKLLQKDPRCLTHMFAAEIFMHRFLLSSPVRTRNPDEADWFYTPIYPTCDLTPTGLPLPFKSPRMMRSSIQLISSNWPYWNRTEGADHFFVVPHDFGACFHYQEEKAIERGILPLLQRATLVQTFGQRNHVCLDEGSITIPPFAPPQKMQAHFIPPDIPRSIFVYFRGLFYDVNNDPEGGYYARGARAAVWENFKNNPLFDISTDHPTTYYEDMQRAIFCLCPLGWAPWSPRLVEAVVFGCIPVIIADDIVLPFADAIPWEEIGVFVAEKDVPELDTILTSIPTEVILRKQRLLANPSMKRAMLFPQPAQPGDAFHQILNGLARKLPHDKSIYLKTGEKALNWTAGPVADLKPW
Protein: Degringolade, isoform A (GM01182p) (Q9VNJ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO12017p1
- KxDL motif-containing protein CG10681
- Uncharacterized protein, isoform C
- Uncharacterized protein, isoform A
- LD33778p
- Tropomyosin-1, isoforms 9A/A/B
- Small ubiquitin-related modifier
- DNA repair protein Rad60
- Dorsal interacting protein 4
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MSDSTIFRFNSSILDQSADSNVSSSSSNSSVSDSSVDSHSSIESNSGHNTSVESQSSAESDSSADSHSSLERPSPVERDLSVESDSSSATNTSESSVGEASNQLQSPQSNNPLNMANLSVSTEDAHSQIRSLTQDVIQMEAELDRMNRYCEEVVAQIDTFATRTSTPTTRRIRRRTSPVEVIDLSHLDRAPPVRSARNRDPDAFIDLCTPEGPRSRTVNLHSNDSLTILPRRSAENDPVVDLDVASPPKRVNRDIDESQKEELYKCPICMDSVSKREPVSTKCGHVFCRECIETAIRATHKCPICNKKLTARQFFRIYL