wanglab/gogpt-training-data huggingface dataset:
Protein: Fanconi anemia group G protein (Protein FACG) (DNA repair protein XRCC9) (O15287)
Organism: Homo sapiens (Human)
Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
Subcellular location: Nucleus {ECO:0000269|PubMed:18550849}. Cytoplasm {ECO:0000269|PubMed:18550849}. Note=The major form is nuclear. The minor form is cytoplasmic.
Interaction partners:
- Fanconi anemia group F protein
- FA core complex associated protein 20
- Centromere protein S
- Centromere protein X
- Fanconi anemia group E protein
- E3 ubiquitin-protein ligase FANCL
- Fanconi anemia group I protein
- Fanconi anemia group C protein
- Fanconi anemia group B protein
- Fanconi anemia group M protein
Sequence:
MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKHILASRCLQTGRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLSWIRPSDRDAFLEEFRTSLPKSCDL
Protein: Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) (Q86TV6)
Organism: Homo sapiens (Human)
Function: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:23229899}. Cell membrane {ECO:0000269|PubMed:23229899}. Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with EFR3 (EFR3A or EFR3B) (PubMed:23229899). {ECO:0000269|PubMed:23229899}.
Interaction partners:
- Hyccin
- Phosphatidylinositol 4-kinase alpha
- Protein EFR3 homolog B
- Protein EFR3 homolog A
Sequence:
MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAGDIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIPRVL
Protein: Major heat shock 70 kDa protein Aa (Heat shock protein 70Aa) (HSP70-87A7) (P82910)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Heat shock protein 83
- Heat shock protein 23
- Heat shock protein 26
- Heat shock protein 27
- Heat shock protein 22
- DnaJ-like-2, isoform A
- GrpE protein homolog, mitochondrial
- Stress-induced-phosphoprotein 1
- LD28549p
- Hsc70Cb, isoform G
Sequence:
MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDAKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQAVEQAPAGKLDEADKNSVLDKCNDTIRWLDSNTTAEKEEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPGANCGQQAGGFGGYSGPTVEEVD
Protein: Neuropeptide Y receptor type 1 (NPY1-R) (P25929)
Organism: Homo sapiens (Human)
Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Peptide YY
- Pro-neuropeptide Y
- Guanine nucleotide-binding protein G
- Pancreatic polypeptide prohormone
- Appetite-regulating hormone
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Neuropeptide Y receptor type 5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
Protein: Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain] (Q63207)
Organism: Rattus norvegicus (Rat)
Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Antithrombin-III
- Prothrombin
- Tissue factor
- Tissue factor pathway inhibitor
- Coagulation factor VII
- Coagulation factor V.
- Coagulation factor IX
- von Willebrand factor
- Coagulation factor VIII
- Complement C3
Sequence:
MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSFFEEIKKGNLERECVEEICSFEEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECRDGLGSYTCTCTEGFEGKNCELFVRKLCSLDNGDCDQFCREEQNSVVCSCAKGYFLGNDGKSCLSTAPFPCGKTNKGRAKRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNLNKTEPEANSDDVIRIVGGQECKRGECPWQALLFSDEETDGFCGGTILNEFYILTAAHCLHQAKRFKVRVGDLNTEQEDGGEMVHEVDMIIKHNKFQRDTYDFDIAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTGIVSGFGRTHEKGRQSKVLKMMEVPYVDRNTCRLSTSFSITQNMFCAGYDAKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKARVGPTSETPRLTHPPY
Protein: Small ribosomal subunit protein eS19 (40S ribosomal protein S19) (Q9CZX8)
Organism: Mus musculus (Mouse)
Function: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P39019}.
Interaction partners:
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein eL43
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL33
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL37
Sequence:
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVRPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH
Protein: RNA helicase (EC 3.6.4.13) (D3ZUC2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, P-body {ECO:0000256|ARBA:ARBA00004201}.
Interaction partners:
- Protein argonaute-2
- Protein argonaute-1
- Fragile X messenger ribonucleoprotein 1
- Endoribonuclease Dicer
- Trinucleotide repeat containing adaptor 6A
- ATP-dependent RNA helicase
- ATP-dependent RNA helicase A
- Trinucleotide repeat-containing gene 6C protein
- Protein argonaute-3
- ATP-dependent RNA helicase
Sequence:
MSWALPFALQLFVPRLWRVGVGVALAEAPRSSRLFRGPQAIATFGSWLAARGGSLGFISDPPAWAAAAAAMPSKFSCRKLRETGQGFESFLAERGLDLETDRERLRAIYNRDFKPSYGTPAPGFSSMLYGMKIANLAFVTKTRVRFFKLDRWADVQLPEKRRIKPGSSISKQHRSLLARIFHDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTKPVTLTHLFPLCWTPQFVFYHGEQDLPCPLGPGESYELHVYCKTSIVGYFPATVLWELLGPGESGAEGAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNPVSTNRIEEGERPDRAKGYELELSLALGTYYPPIRLRQLLPTLLQGPSIFTSPKEVAEIKAQLETTLKSRNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSEIQQEDPVTYKGFVHKVELDRVKLSFSPSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWVLWPTLFPVASRGVSLLPSDVKFKLYDRSLESNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKTCCNWDPKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERLLTYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLRQLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPSTSGPRRHQRLPQEREGEEGLPLQVEPEWRNEL
Protein: Truncated Kidins220 isoform m6 (A0A076N9K6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
VRAAREQINIGGLAYPPLPLHEAPPRPPSGYSQPASVCSSSASFNGPFPGGVVSPQPHSSYYSGLSGPQHPFYNRASVPATGTSLLLSSMTVDIVCEKLRQIEGLDQGMLPQYCTTIKKANINGRVLAQCNIDELKKEMAMNFGDWHLFRSMVLEMRSVENQVVPEDPRFLNENSSAPVAHGESARRTSHSELPHTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGTGSSTISGRSSPHSTYYIGQSSSGGSIHSNLEQERGKENELKQEEGRKSFLMKRGDVLDYSSSGVSTNEASPLDPITEEDEKSDQSGSKLLPGKKSSERPSLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDKKAEGKAERVAKSPEHSVEPIRTFIKAKEYLSDALLDKKDSSDSGVRSNESSPNHSLHNEAADDSQLEKANLIELEDEGHSGKRGMPHSLSGLQDPVIARMSICSEDKKSPSECSLIASSPEESWPSCQKAYNLNRTPSTVTLNNNTAPTNRANQNFDEIEGVRETSQVILRPGPSPNPTAVQNENLKSMAHKRSQRSSYTRLSKDASELHAASSDSTGFGEERESIL
Protein: Uncharacterized AAA domain-containing protein C328.04 (Q9P3U2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:10759889}.
Interaction partners:
Sequence:
MSLEDCYNVTQSYAAVAIHKEQTADYVEAIALFQKAKRNILMNPEFKYARERLHVMDYEDRHYVETLLCMLEQLTIRIEFLTKEIAQQEAAYKDIQNTQKSLVTQSSTGSANVAYISGNGPGDRSFIDDGNYSASSFERQNRTAPLQSKVTTASLKPNIPRTSMSSSPTASRTSLRKGAGELETHSAVKSAKKASVKSKSVLPPSKSLARTGLPAEVSTQNNANRAALLAWGSLNSSKPKHALPPSYISSEAAQASRSSFQVERHRPTPDNSAVIEAARRTYSSISSSSSPFKKKTQSHLPNRTTEVPSISKQLSKSSTSIATVAPSLASVSSVTKSPSPTPQSAPRAQSASTETAQDLDFLTPPRLSVNNPFLSDLYPASEQGLSSCEEKDSPVDGDEFFNHTNEEEIIEKQFQSTSISAMTSEKQEQILRECPDIDEELGKSILREIVVSGDEVHWDDISGLEFAKHSLKEAVVYPFLRPDLFQGLREPARGMLLFGPPGTGKTMLARAVATESRSVFFSISASSLTSKFLGESEKLVRALFTLAKKLSPSIIFVDEIDSLLSARSSDGNEHETSRRIKTEFLIQWSSLARAAASRQTADHPRVLVLAATNLPWCIDDAARRRFVRRTYIPLPDETTRRLHLNNLLKYQKHSLSLEDIEAIVKATEYYSGSDLTALAKDAAMGPLRSLGESLLFTKMESIRPINLDDFKTSIKVIRPSVNLQGLERYSEWDKEFGSQGH
Protein: DISCO interacting protein 1, isoform B (A4V4V2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVSVGQRVAFLSTHWTSPLQNPNATVKPLIQMPLQAANVQEQQSSPVALYPTSASPVAVQSPQDAFLAVQSPGAPAPVQLANSSDQQNNPDADAIASKLPMPVIIKEEPISVNDEPSVDNIEDNTSASTSASGIGGKIPFKKIFQKRKKSSERTRDKKLRQNRQLRKSMLPKNALMALNEVKGVTISDFTIDSNTDGGFTAVVTVNSNQYEGKGTSKMTAKNAACEKAWRDFIIAKMTPKPPRIHQVEMGSEPMDINEDEADAPDDDLPMLNLASFAIYKLFAEWEREGYVVPEMHPSANAAQQAGGDAGTPVPPVPKEPKKPPVRTELPSGWETMHPATILCIMRPGLNYVDYGSSGDKTNGMQHLGIMVDNQEFHANGRSKKIARRNVAVKVCNSLFGTNFTYSDTT
Protein: Actin-18 (EC 3.6.4.-) (Actin-3-sub 2) (P07828)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 1
Sequence:
MEREEVQAIVIDNGSDMCKAGFAGDDAPRAVFQSIVGRPRYTGVMDVMGQKDSYIGDEAHSRKGFLTLKYPIERGIVTNWDDMEEIWHHTFYNELGVAPEEHPVLLTEQPLNPKKNREKMTQIMFETFNTPAMYVAIQAVLSLYSSGRTTGIVMDSGDGVSHAVSIYEGHALPHAILRLDLAGRDLSDYMMKILTKRGYSFTTTAEKEIIKDIKEKLSYVALDFDAEMLTAASSTTLEKSYELPDGKVITIGNERFRCPEALFQPSLLAMESAGIHETIYNSIMKCDVDIRRYLFGNVILSGGSTMFPGIADRMNKELTALAPSTMKIKIIAPPERKYSVWVGGSILASLSSFQEMWISKEEYNESGPSIVHRKCSNYLK
Protein: Cyclin/Brf1-like TBP-binding protein (Putative transcription factor) (Q0WVQ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Homeodomain-like superfamily protein
- Tetratricopeptide repeat
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerase III subunit 2
- Plant-specific TFIIB-related protein 2
- DNA-directed RNA polymerase III subunit 1
- Transcription initiation factor IIB-2
- Plant-specific TFIIB-related protein 1
- Transcription initiation factor IIB-1
- TATA-box-binding protein 1
Sequence:
MVWCNHCVKNVPGIRPYDGALACNLCGRILENFHFSTEVTFVKNAAGQSQASGNIVRSVQSGITSSRERRFRIARDELMNLKDALGIGDERDDVIVIAAKFFEMAVEQNFTKGRRTELVQASCLYLTCRELNIALLLIDFSSYLRVSVYELGSVYLQLCEMLYLVENRNYEKLVDPSIFMDRFSNSLLKGKNNKDVVATARDIIASMKRDWIQTGRKPSGICGAALYTAALSHGIKCSKTDIVNIVHICEATLTKRLIEFGDTDSGNLNVNELRERESHKRSFTMKPTSNKEAVLCMHQDSKPFGYGLCEDCYKDFINVSGGLVGGSNPPAFQRAEKERMEKAAREENEGGISSLNHDEQLYSDYCSMSKRGKQCSEKGEKDKDGAEEHADTSDESDNFSDISDDEVNGYINNEEETHYKTITWTEMNKDYLEEQAAKEAALKAASEALKASNSNCPEDARKAFEAAKADAAKSRKEKQQKKAEEAKNAAPPATAVEAVRRTLDKKRLSSVINYDVLESLFDTSAPEKSPKRSKTETDIEKKKEENKEMKSNEHENGENEDEDEEDEEEGNVESYDMKTDFQNGEKFYEEDEEEEEDGNDFGLY
Protein: beta-galactoside alpha-(2,6)-sialyltransferase (EC 2.4.3.1) (Q9W121)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000256|ARBA:ARBA00004447}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004447}.
Interaction partners:
Sequence:
MRQVTRASSGQSQALLSCLIIAVCAALIIQSGHIQGVKAQPGREPGEVNSRQPGNGNGTTGHRVPRSVFHVRWNPNEKFIVESRENPAINSSKLAPHPRLKVSKNTKLTLSPKLYLCHDKHSELCHNKTQQFRQRIVRAFEKAMVESVNESQANHYNVDYKPVFGDSFEEQYYPSTCLVMEAGVRVLRRKDAPFNKLPFGRLFPRQKLFRNVKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTKPEFDFTRAPIFRNVTIAAWDPGKYNGTLEDWLTSADYDLFSNYELYRRRYPKSRAFLIDPHSVWRLWQSLQMFAGNRPISKNPPSSGFIGLALLLPHCPQVDFVEYVPSTRLNGRCHYYSKEMNSACTFGSWHPLAAEKLMALDMNMAEDDDMSVFQFGILRIRRPDKLLCGFNFFGY
Protein: Protein LF2 (P0C725)
Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Function: Prevents the establishment of cellular antiviral state by blocking the cellular IRF7-mediated innate immunity. May also inhibit viral replication by modulating BRLF1 activity.
Interaction partners:
Sequence:
MAEAYPGGAHAALASRRSSFRNSLRRLRPTEKPDTSFMRGVWKYEIFPSYVRVTNKQVLQLDAQCQELPPCPSVGQILSFKLPSFSFNTTTYGSRYFTVAFLFFGAEDNEVFLKPFFVMHSDQDIVLSVLNPRSLFIEKGKFTWYIVPIRLVKNPYLYLQILPGQSDIQLTRSCTQSGDKLNTSEPQIFLSGSPVTSQDECLPYLLAQHTPPFLKSYARIHTFPGKVCPVNAIRRGKGYVRVSVDTPDLKREGPLNVKVGMTLLDDVIIAFRYNPYPKSHWRWDGESTDIRYFGSPVIIPPNFITELEYNNTYEAPLSSKITAVVVSHSSNPVFYVYPQEWKPGQTLKLTVRNISNNPITIVTGQSMAQAFFIYAGDPSISTIMRRYIQRQGCALTLPGNIVVESSSLPTFERINKTFNGNIVASEGTL
Protein: Olfactory receptor 11A1 (Hs6M1-18) (Olfactory receptor 11A2) (Olfactory receptor OR6-30) (Q9GZK7)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MEIVSTGNETITEFVLLGFYDIPELHFLFFIVFTAVYVFIIIGNMLIIVAVVSSQRLHKPMYIFLANLSFLDILYTSAVMPKMLEGFLQEATISVAGCLLQFFIFGSLATAECLLLAVMAYDRYLAICYPLHYPLLMGPRRYMGLVVTTWLSGFVVDGLVVALVAQLRFCGPNHIDQFYCDFMLFVGLACSDPRVAQVTTLILSVFCLTIPFGLILTSYARIVVAVLRVPAGASRRRAFSTCSSHLAVVTTFYGTLMIFYVAPSAVHSQLLSKVFSLLYTVVTPLFNPVIYTMRNKEVHQALRKILCIKQTETLD
Protein: Desmin (Q5XFN2)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin.
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:24413773}. Cytoplasm {ECO:0000250|UniProtKB:P17661}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P17661}. Nucleus {ECO:0000250|UniProtKB:P31001}. Cell tip {ECO:0000250|UniProtKB:P31001}. Nucleus envelope {ECO:0000250|UniProtKB:P31001}. Note=Localizes in the intercalated disks which occur at the Z line of cardiomyocytes. Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes. PKP2 is required for correct anchoring of DES at the cell tip and nuclear envelope (By similarity). {ECO:0000250|UniProtKB:P17661, ECO:0000250|UniProtKB:P31001}.
Interaction partners:
- Phosphate cytidylyltransferase 1, choline, alpha.
Sequence:
MSQAYSSSQRVSSYRRTFGGAGGFPLGSPLGSPVFPRAGFGTKGSSSSVTSRVYQVSRTSGGAGGLGALRAGRLGTGRAPSYSAGELLDFSLADAVNQEFLTTRTNEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREPTRVAEIYEEELRELRRQVEVLTNQRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMREMEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRINLPIQTYSALNFRETSPEQRGSEVHTKKTVMIKTIETRDGEVVSEATQQQHEVL
Protein: Chondroadherin (Cartilage leucine-rich protein) (O55226)
Organism: Mus musculus (Mouse)
Function: Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Integrin alpha-2
- Integrin beta-1
- BPI fold-containing family A member 2
- Amelogenin, X isoform
- Integrin, alpha 10
- Integrin alpha-8
- Integrin alpha-11
Sequence:
MARALLFSLVFLAILLPALAACPQNCHCHGDLQHVICDKVGLQKIPKVSETTKLLNLQRNNFPVLAANSFRTMPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVSELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGSLDDVENLAKFHLDKNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDAAFSGVTTLKHVHLDNNRLNQLPSSFPFDNLETLTLTNNPWKCTCQLRGLRRWLEAKASRPDATCSSPAKFKGQRIRDTDALRSCKSPTKRSKKAGRH
Protein: Syntaxin-11 (Q9D3G5)
Organism: Mus musculus (Mouse)
Function: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
Subcellular location: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Synaptosomal-associated protein 23
- Syntaxin-binding protein 2
- Vesicle-associated membrane protein 8
- Protein unc-13 homolog D
- Vesicle-associated membrane protein 2
- Syntaxin-binding protein 5
- Syntaxin-19
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 4
- Syntaxin-12
Sequence:
MKDRLAELQELSRSYDQQFPDGDNDFDAPREDIVFETDNILESLYRVIQDIQDENQLLLIDVRRLGRQNVRFLTSMRRLSSIKRDTNSIAKAIKTRGEGIHQKLRSMKELSEQAEARHGAHSAVARISHAQYSALARAFQQAMYEYNQAEMKQRDNCKIRIQRQLEIMGKDMSGEQIEDMFEQGKWDVFSENLLADLKGARAALNEIESRHRELLRLEGRIRDVHELFLQMAVLVEKQEDTLNVIELNVQKTLDYTGEAKAQVRKAVQYKKKNPCRTICCFCCPCVN
Protein: Carboxypeptidase, putative (EC 3.4.17.19) (Q386R0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- GrpE protein homolog
Sequence:
MKAYKELERVFTKLYRYEHFMNLAGWDMQAIMPPNAMEARGAAIAELEVLMHGEITNPKVKTFIEEAEGSVGELNELQRANLREIRRSWEKVNRLPEAFVERKALLTSNSQQLWKKCREENDFAGFLPTFKELVELYREEGKLLAGTTGVHPYEALVDVYEPGMTLKQLDIIFENVKSWLPNLLKEVLEKQKSLNASIVQPKGPFPIAKQETLGRACMKLWKFNFDGGRLDVSAHPFCGNVKEDVRITTSYNENDFAKSLFGVIHETGHAKYEQNLGPVEFTTQPVCRARSLGVHESQSLFAEMQIGLSGAFMNALSPMLVEHFGEQPAFTPTNMKRVLQQVQPSLIRIEADELCYPLHVILRCEIERDLIDRKIEAEDVPRAWNEKMKAYFGLETLGNDKEGCLQDIHWFGGAFGYFPTYLLGAMLAAQLMHTVRRELGENVVEDCLMKADLDVIFAKQKEKIWRHGSSLLTEELIKQATGEPLNPQYHREHLERRYRDDAN
Protein: Persulfide dioxygenase ETHE1 homolog, mitochondrial (EC 1.13.11.18) (Glyoxalase II) (Glx II) (Sulfur dioxygenase ETHE1) (Q9C8L4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) gives rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. Required for normal endosperm development in seed, and thereby also required for normal embryo development.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:22786886}.
Interaction partners:
- Lactoylglutathione lyase
- Lactoylglutathione lyase GLX1
- Probable lactoylglutathione lyase, chloroplastic
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 2
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial
- Assimilatory sulfite reductase
- Sulfite oxidase
- 5'-adenylylsulfate reductase 3, chloroplastic
- 5'-adenylylsulfate reductase 2, chloroplastic
- 5'-adenylylsulfate reductase 1, chloroplastic
Sequence:
MVMTHFSRLRQLLLLQPKFLSSQPRPLRSPPPTFLRSVMGSSSSFSSSSSKLLFRQLFENESSTFTYLLADVSHPDKPALLIDPVDKTVDRDLKLIDELGLKLIYAMNTHVHADHVTGTGLLKTKLPGVKSVISKASGSKADLFLEPGDKVSIGDIYLEVRATPGHTAGCVTYVTGEGADQPQPRMAFTGDAVLIRGCGRTDFQEGSSDQLYESVHSQIFTLPKDTLIYPAHDYKGFEVSTVGEEMQHNPRLTKDKETFKTIMSNLNLSYPKMIDVAVPANMVCGLQDVPSQAN
Protein: Cytochrome P450 76C4 (EC 1.14.-.-) (O64635)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- NAD
- Patched family protein
- Patched family protein
- Putative ion channel POLLUX-like 2
- UDP-glycosyltransferase 91B1
- NAD
- NAD
- Aldo-keto reductase family 4 member C11
- UDP-glycosyltransferase 91C1
Sequence:
MDIISGQALFLLFCFISSCFLISTTARSRRSSGRAATLPPGPPRLPIIGNIHQVGKNPHSSFADLAKIYGPIMSLKFGCLNSVVITSPEAAREVLRTHDQILSGRKSNDSIRCFGHEEVSVIWLPPSSARWRMLRKLSVTLMFSPQRTEATKALRMKKVQELVSFMNESSERKEAVDISRASYTTVLNIISNILFSVDLGSYDSKKSNEFQDTVIGAMEAAGKPDAANYFPFMGFLDLQGNRKAMRGLTERLFRVFRGFMDAKIAEKSLGNYSKDVSNRDFLDSLLILNEGDEAELDNNDIEHLLLDMFTAGTDTSSSTLEWAMAELLRNPKTMVKAQAEMDRVLGQNSVVQESDISGLPYLQAVVKETFRLHPAAPLLVPRKAESDVEVLGFMVPKDTQVLVNVWAIGRDPSVWENPSQFEPERFMGKDIDVKGRDYELTPFGGGRRICPGLPLAVKTVSLMLASLLYSFDWKLPNGVVSEDLDMDETFGITLHRTNTLYAIPVKKQTIN