wanglab/gogpt-training-data huggingface dataset:
Protein: Quinate repressor protein (Q00784)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Multi-domain repressor protein that negatively regulates transcription of the quinate utilization pathway genes. May mediate its repressor activity by binding directly to the qutA activator protein.
Interaction partners:
- Quinic acid utilization activator
- Multifunctional tryptophan biosynthesis protein
Sequence:
MSILVRPPKRRLADTENLDQNHRRVLRDFGQGNSASTPINTSADYGRFDERPGSGDGSRYASPFQELSSSQGSLTRVEDSLQTRRKFPPNASIVLIGIRGTGKSSLAVMLAASYGRRVIEADLYFQRVTGRCRGVYKREHTLSEYRRQEAIVMESLLMEHQENCVIVCGPGDVERNGQMRLREYAKTHPVIHIVRDLESIQSYLKARDTEKVRRFLELSGPIYRSCSNLEFFNVSEKGISDQPSAKDSQHYTQWDAEVDQRTQTTTPFLMLKRLQRDFLRFVALATGNIPELRNQLSPFPLHMQPIESRKFTYAATVPISHLLENDVDIEELESTADAFELKIDVSAAPSARLGTESNLADSISHTVATVRRNIIVPMIYHVESSVFPDSAPLRRSDASYLELVLHGLRLGPEFVTVDLSFEDSILSQIIGTKGSSKVIGHYSQTQPPPQGWSDPEYEAIYERAKKLGCDMVRLTQPATTIDDNFAVERFRHQIKTLPGPQLPVIAYNSGPLGRQSCCFNPVLTPVIPRSLISQSGTKGLPSITIQEAQEALYSSFVLDPMQFFVFGANTTYSLSPAMHNAAFKVRGMPHIYRIHQSPTLRGINYLVENPNFGGTSVSLPYKTEVIPLLHSMSPHARAIGAVNTLIPIRNLEGSTDNALDLEKNRAGPIKGLHGDNTDWIGIGICIRRGLSPANAIRPSTTGLIIGAGGMARAGIYAMIHLGVQNIFIWNRTVANAEKLAQHYMRLNLCTLGGSGSASYTIHVLKSLQESWPANYKQPTIVVSGIPAHRIGDQPAPNFQLPPQWIESPTGGVVVDLAYKPLNTPLMRQIRSLSHRGWAALDGLDVLPEQGFAQFELFTGCRAPRRLMRTVILQEYKEEEQGEEYDQSAMRTRLENLDGQPM
Protein: Histone H1 (P54671)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H4
- Histone H2B.v3
- Cyclin-dependent kinase 5 homolog
- Histone H2A.z
- Histone H3.3 type a
- Histone H3.3 type c
- Cyclin-dependent kinase 1
- Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007
- Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550
- Histone H3.3 type b
Sequence:
MGPKAPTTPTKKAAATKSKPKPNHPTYQVMISTAIAHYKDRTGSSQPAIIKYIEANYNVAPDTFKTQLKLALKRLVAKGTLTMVKASYKLSEEGKKEHQATLGPVAKKPKAKTTATSTETTAAPPATPTKKAAPKKPAAKAASTSTKTAAAKKNSAKVTKAVSKKPAAKKAPSKKVAAKK
Protein: Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) (Q99590)
Organism: Homo sapiens (Human)
Function: Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly.
Subcellular location: Nucleus {ECO:0000269|PubMed:9447963}.
Interaction partners:
- Splicing factor U2AF 65 kDa subunit
- Arginine/serine-rich protein PNISR
- Caspase-4
- Splicing factor U2AF 35 kDa subunit
- Serine/arginine-rich splicing factor 2
- Nipped-B-like protein
- Bcl-2-associated transcription factor 1
- Caspase-1
Sequence:
MKKKTVCTLNMGDKKYEDMEGEENGDNTISTGLLYSEADRCPICLNCLLEKEVGFPESCNHVFCMTCILKWAETLASCPIDRKPFQAVFKFSALEGYVKVQVKKQLRETKDKKNENSFEKQVSCHENSKSCIRRKAIVREDLLSAKVCDLKWIHRNSLYSETGGKKNAAIKINKPQRSNWSTNQCFRNFFSNMFSSVSHSGESSFTYRAYCTEFIEASEISALIRQKRHELELSWFPDTLPGIGRIGFIPWNVETEVLPLISSVLPRTIFPTSTISFEHFGTSCKGYALAHTQEGEEKKQTSGTSNTRGSRRKPAMTTPTRRSTRNTRAETASQSQRSPISDNSGCDAPGNSNPSLSVPSSAESEKQTRQAPKRKSVRRGRKPPLLKKKLRSSVAAPEKSSSNDSVDEETAESDTSPVLEKEHQPDVDSSNICTVQTHVENQSANCLKSCNEQIEESEKHTANYDTEERVGSSSSESCAQDLPVLVGEEGEVKKLENTGIEANVLCLESEISENILEKGGDPLEKQDQISGLSQSEVKTDVCTVHLPNDFPTCLTSESKVYQPVSCPLSDLSENVESVVNEEKITESSLVEITEHKDFTLKTEELIESPKLESSEGEIIQTVDRQSVKSPEVQLLGHVETEDVEIIATCDTFGNEDFNNIQDSENNLLKNNLLNTKLEKSLEEKNESLTEHPRSTELPKTHIEQIQKHFSEDNNEMIPMECDSFCSDQNESEVEPSVNADLKQMNENSVTHCSENNMPSSDLADEKVETVSQPSESPKDTIDKTKKPRTRRSRFHSPSTTWSPNKDTPQEKKRPQSPSPRRETGKESRKSQSPSPKNESARGRKKSRSQSPKKDIARERRQSQSRSPKRDTTRESRRSESLSPRRETSRENKRSQPRVKDSSPGEKSRSQSRERESDRDGQRRERERRTRKWSRSRSHSRSPSRCRTKSKSSSFGRIDRDSYSPRWKGRWANDGWRCPRGNDRYRKNDPEKQNENTRKEKNDIHLDADDPNSADKHRNDCPNWITEKINSGPDPRTRNPEKLKESHWEENRNENSGNSWNKNFGSGWVSNRGRGRGNRGRGTYRSSFAYKDQNENRWQNRKPLSGNSNSSGSESFKFVEQQSYKRKSEQEFSFDTPADRSGWTSASSWAVRKTLPADVQNYYSRRGRNSSGPQSGWMKQEEETSGQDSSLKDQTNQQVDGSQLPINMMQPQMNVMQQQMNAQHQPMNIFPYPVGVHAPLMNIQRNPFNIHPQLPLHLHTGVPLMQVATPTSVSQGLPPPPPPPPPSQQVNYIASQPDGKQLQGIPSSSHVSNNMSTPVLPAPTAAPGNTGMVQGPSSGNTSSSSHSKASNAAVKLAESKVSVAVEASADSSKTDKKLQIQEKAAQEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAYVDKYKYSRKGSQKKTLEEPVSTEKNIG
Protein: Phosphatidylinositol 3-kinase VPS34 (EC 2.7.1.137) (Q6FSR7)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P22543}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22543}. Endosome membrane {ECO:0000250|UniProtKB:P22543}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22543}.
Interaction partners:
- Vacuolar protein sorting-associated protein 30
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase ATG1
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Candida glabrata strain CBS138 chromosome J complete sequence
- 1-phosphatidylinositol-3-phosphate 5-kinase
- Autophagy-related protein 18
- Autophagy-related protein 3
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
- Candida glabrata strain CBS138 chromosome J complete sequence
Sequence:
MSGKSVSFYVSENIDVPLQIKILSLKGKKRQLRASEKLIDPQLSLTMSNVKIFSDMLVSVQVYDELTLGDVTVPVFAPYVPFRYGRNWDQWVTLPVSVRHLTPACKLRIVLWEFNGQRRIPFKTITTPIFKDLDFTLKRGIEAIKFTKQGKPSIETVKTLETINKYFYGDYAKKEWIDELVLKKLYKEYEKIDLPLDTFMLTIQFPVIELPIIYTEKPREDIQKNIPTLSNFDAASAFSVDHSTSNNTAVTSVDPKLKIPMGNKYNSTLKFYDPDQFNNDPIEEKFRKLERASKHNTSDKHVKPDAKKRDYLKKIIDYPPGKRLSAHEKGSIWKYRYYLQNNKKALTKLLQSTNLKDETERTEVLEMMDGWAEIDIDDALGLLGHKYRNLAVRTYAVNRLKKASDKELELYLLQLVQAVCFENLNTFSDTSNSKFTVVDFSSSSQMMKTRNTQRSESQNIMNSHIENNNPKFIHSIHSEDDSQIEELPVVISPLAEFLIRRALVNKRLGNYFYWYITSESYDQPFLNQILESFLSRLNSNDRNEIEKQVKLLTLLRNCCEEIKSLKDTVSKKKELLQTLLSTKVRPYLKKRLVKLPLDPDIVLNDVMIDQCNVFKSSLSPLMITFHTENGGVYPLMYKVGDDLRQDQLVVQIISLMNELLKNENVDLKLLPYTILATGLEEGAIQFIPNLTMADILNKYHGILPFFRAHHPDKDEELGVKSWVIDNFVKSCAGYCVITYLLGVGDRHLDNLLITEGGQFFHADFGYILGQDPKPFPPLMKLPPQIIEAFGGTDSSNYNKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRVDPEGSIMKVKERFNLDLTEEEATIHFQTLINDSVNALLPIVIDHLHNLAQYWRA
Protein: NUMB-like endocytic adaptor protein (Numb-like protein isoform X1) (A0A286Y8T8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSFSSDMDETEDGSTREFESVEMNKLRQSLRRKKPTYVPEASRPHQWQADEEAVRKGKCNFPVRYLGLVEVDESRGMHVCEEAVKKLKVSGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNYDKAFSYICRDGTTRRWMCHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDASRTSFVREGSFRVSSAAQQSDREDIMKQIQDKKKEMCGISALPPGNASPPEGAGSPGERAEPGGPHAIPRRHAPIEQLVRQGSFRGFPQLSQKNSPFKRQLSLRLNDLPSTLQRKTDFQTKNPVPEMDLTVAGEADSINALCSQINSSFTKPSEDLCAKTTNNCLPISCAPPAIPPPPAPPQATNLWVQIEPPVQSSPPIPQGGHKRTPSEAERWLEEVAKAVKSQQQTPPTLPPPPTQQPPPVPTMPIAPGSLPTSMQPFPMAFDVTPAPVSMFTQQPLQPAFVPMQPYMPTLANSMTYPNASVPVVGITPSQMVANVFCSAAGTGGGVAIGVGMGPKTGTLGGSQHSAFPTLPGGLPTTTFASPPTINGHPQNSFPSTTTSVTQNGTAVKGGSGWPMENPNPTINSKEAEHFDAKWAALESKSQPKAQNPFSNDLQKTFEIEL
Protein: Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36) (Q8WTV0)
Organism: Homo sapiens (Human)
Function: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26965621}; Multi-pass membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:Q61009}; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Interaction partners:
- Apolipoprotein A-I
- Apolipoprotein B-100
- Toll-like receptor 4
- Toll-like receptor 2
- CD81 antigen
- Leukocyte surface antigen CD47
- Thrombospondin-1
- Toll-like receptor 6
- Tyrosine-protein kinase Lyn
- Apolipoprotein E
Sequence:
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS
Protein: RRM domain-containing protein (Q21323)
Organism: Caenorhabditis elegans
Interaction partners:
- Probable U2 small nuclear ribonucleoprotein A'
- U1 small nuclear ribonucleoprotein C
- Probable small nuclear ribonucleoprotein-associated protein B
- Small nuclear ribonucleoprotein Sm D3
- Probable small nuclear ribonucleoprotein Sm D2
- Probable small nuclear ribonucleoprotein Sm D1
- Probable small nuclear ribonucleoprotein F
- U1 small nuclear ribonucleoprotein 70 kDa
- Probable small nuclear ribonucleoprotein G
- PHD finger-like domain-containing protein 5A
Sequence:
MADINPNHTIYVNNLNEKVKKDELKRSLHMVFTQFGEIIQLMSFRKEKMRGQAHIVFKEVSSASNALRALQGFPFYGKPMRIQYAREDSDVISRAKGTFVEKRQKSTKIAKKPYEKPAKNGKSAAEPTQKEPQETDGPGLPNNILFCSNIPEGTEPEQIQTIFSQFPGLREVRWMPNTKDFAFIEYESEDLSEPARQALDNFRITPTQQITVKFASK
Protein: Lysine demethylase 4C (A0A8I6A3B2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVTGQSGLFTQYNIQKKPMTVKEFRQLANSSKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRNDMVKISMDIFVKKFQPDRYQIWKQGKDIYTIDHTKPTPESTPEVKTWLQRRKKLRKAPKSLQGNKSLSKRPKAEEDEEFAEFIGEEVSSPAVCPRHLKVTEKPEKFKLANIGASSEKEASDTRIQVDQSLTNDTKLSGKSCINSSVIDEIQPENDTANAVTSPSTLKKASDLIPFSHGHITGKESRLLKILQLESPKIPSSLAESNRVLTEGEENDEEGHASNLEPGEVPDALSEERNGLNVPKIIEGQPKTTKSWRHPLGKPPARSPMTLVKQQVASDEELPEVLSIDEEVEETESWAKPLIHLWQTKSPNFMAEQEYNATVAKMEPNCAICTLLMPYYKPDNSKEENDSRWETAVNEVVQSGRKTKPIIPEMCFIYSEENVEYSPPNAFLEEDGTSLLISCSKCFVRVHASCYGVPSHEVCDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNQWAHVICAVAVPEVRFTNVPERTQIDVDRIPLQRLKLKCIFCRQRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHRVNSNVKSKTCEKAISVGQTVITKHRNTRYYSCRVIDVTSQIFYEVMFDDGSFSRDTFPEDIVSRNCVKLGPPAEGEVIQVKWPDGKLYGAKYLGSNVAYMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADVIQGERKRQRVLSSRLKNEYVDDPVYRTFLKSSFQKKCQKRQ
Protein: Uncharacterized protein, isoform A (Q9VML7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKFLTVFAFACVATFVVLHGAYGSPLPEPIPDPSPVADPSPAANPSPVADPKPVAEPSANPGTGTNAEPGPRSKPNPSPSAPATLLEANKQDNFAVPLLETAPQKLDDVQADPQPA
Protein: Pentatricopeptide repeat-containing protein At4g01990, mitochondrial (Q93WC5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
Sequence:
MMHSVSRLARRFCATLATATAEISGEAAASVPTKAKKHRSIYKKLSSLGTRGGGKMEETLNQFVMEGVPVKKHDLIRYAKDLRKFRQPQRALEIFEWMERKEIAFTGSDHAIRLNLIAKSKGLEAAETYFNSLDDSIKNQSTYGSLLNCYCVEKEEVKAKAHFENMVDLNHVSNSLPFNNLMAMYMGLGQPEKVPALVVAMKEKSITPCDITYSMWIQSCGSLKDLDGVEKVLDEMKAEGEGIFSWNTFANLAAIYIKVGLYGKAEEALKSLENNMNPDVRDCYHFLINLYTGIANASEVYRVWDLLKKRYPNVNNSSYLTMLRALSKLDDIDGVKKVFAEWESTCWTYDMRMANVAISSYLKQNMYEEAEAVFNGAMKKCKGQFSKARQLLMMHLLKNDQADLALKHFEAAVLDQDKNWTWSSELISSFFLHFEEAKDVDGAEEFCKTLTKWSPLSSETYTLLMKTYLAAGKACPDMKKRLEEQGILVDEEQECLLSKICP
Protein: Voltage-gated delayed rectifier potassium channel KCNH1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (m-eag) (mEAG1) (Potassium voltage-gated channel subfamily H member 1) (Voltage-gated potassium channel subunit Kv10.1) (Q60603)
Organism: Mus musculus (Mouse)
Function: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19671703, ECO:0000269|PubMed:23975098}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O95259}. Nucleus inner membrane {ECO:0000250|UniProtKB:O95259}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O95259}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63472}. Cell projection, axon {ECO:0000250|UniProtKB:Q63472}. Presynaptic cell membrane {ECO:0000269|PubMed:25556795}. Perikaryon {ECO:0000250|UniProtKB:Q63472}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q63472}. Early endosome membrane {ECO:0000250|UniProtKB:O95259}. Note=Perinuclear KCNH1 is located to NPC-free islands. {ECO:0000250|UniProtKB:O95259}.
Interaction partners:
- Calmodulin-1
- A-type voltage-gated potassium channel KCND1
- Voltage-gated potassium channel subunit beta-1
- Potassium voltage-gated channel subfamily B member 1
- Voltage-gated delayed rectifier potassium channel KCNH5
- Calmodulin-4
- Calmodulin-like protein 3
- Calmodulin 5
- EF-hand domain-containing protein
- Calcium-activated potassium channel subunit alpha-1
Sequence:
MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPVSFQAATTSTVSDHAKLHAPGSECLGPKAVSCDPAKRKGWARFKDACGKGEDWNKVSKAESMETLPERTKAPGEATLKKTDSCDSGITKSDLRLDNVGETRSPQDRSPILAEVKHSFYPIPEQTLQATVLEVKYELKEDIKALNAKMTSIEKQLSEILRILMSRGSAQSPQETGEISRPQSPESDRDIFGAS
Protein: Periplasmic/secreted acid trehalase ATH1 (cgATH1) (EC 3.2.1.28) (M1RNJ8)
Organism: Candida glabrata (Yeast) (Torulopsis glabrata)
Function: Periplasmic/secreted acid trehalase that catalyzes hydrolysis of the disaccharide trehalose and required for growth on trehalose as carbon source. Growth on trehalose is not restricted to respiration.
Subcellular location: Secreted {ECO:0000269|PubMed:26411890, ECO:0000269|PubMed:33146242}. Periplasm {ECO:0000269|PubMed:26411890, ECO:0000269|PubMed:33146242}. Membrane {ECO:0000250|UniProtKB:P48016}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P48016}.
Interaction partners:
Sequence:
MGFKDKILFWKDEVQYRTLAVADQVANRFLHSFENVYQGDESVEDADSRPVGLTNETLSHSSDFFVLPEERISTRVKIRRQNILNTTLILGMLIALVIWTAILSTNSYFSSSLASASPLFNKEGRVVRPMRESNLGLHADPQTRKSSKTLYDLLSDFDNAFYDDENMILGSLAFGENTYSRQPYVANGYIGSRIPNIGFGYALDTLNLYADAPGALNNGWPLRNRRFAGSFVSDFYSLQAKLNSTNFPELDEKGYTTVISSIPEWTDLQFTVDLNGTKWFNPQSVLIDDVINYNQNLSMKDGIVSTNMDWLNGMINIKSEVWAHRKIHSLGITRLEISLNLDALPDEFTELPVTVYDIIDLNTSHRTTLYEKGQDEDNKAIYMIVNPDNVPYSNAVVYSTCTIKGTENNFSPYNFTSDDRIARNYMTNLTEENPKVVIYKYTSVVSSEYNNDEPNPNVNLKFASNIANTAKGNYKSLLSNHKRAWYDLYNDAFIEIPSDSLLEMTARSSLFHLLANTRQYNVSTTRGLPVGVGGLSSDSYGGMVFWDADVWMAPALLPFFPNIAMNMNNYRNATHQQAIENAKQYNYPGAVYPWTSGRYANCTSTGPCIDYEYHINVDIALASFSIYMNGAEGADEDYLRFTTWPMVKDAAVFFKAYVKYNETLGEYETYNLTDPDEFANHVNNGAFTNAGIKTLLKWATDIGTHLGEEVDPKWMEIADNIHIPRSDSNITLEYSGMNSSVEIKQADVTLMVYPLGYINDESILNNAIKDLYYYSERQSASGPAMTYPVFVAAAASLLNHGSSSQSYLYKSVLPYLRSPFAQFSEQSDDNFLTNGLTQPAFPFLTANGGFLQSILFGLTGLRYSYEVTPRTKKISRLLKFDPVKLPLLPGGIAIRNFKYMGQVLDIIIDDNNGTIAHKGGDKPIRIKVPNRDILHDRNITSALYSKRDDDLSATDDYYGTYFTLYPNEELVIPLYDTKLNIDGNIAESKQITNLTAGVPGDVGFSALDGNNYTHWQPFDKSDNAKLLIDLGFNSTHVIKKGIILWGQRPAKNISLSVLPHSERIEQLFANITDLLETSSITKGGLPLNQMLGQTQSNVTAEIDDDILALLNWKGDDLDQLIPYLPDMHLLQEKFIPILKDYPIKPNQRYYEEIIDDDIIKLLPSNTTEFTIDYNSIPGGEKRARYVVLTVHGTYDDDDDLKGATIREIVLQE
Protein: TMEM (Human TransMEMbrane protein) homolog (Q2A955)
Organism: Caenorhabditis elegans
Interaction partners:
- Cyclin-dependent kinase-like 1
- CEntrosomal Protein
- Transmembrane protein 237 homolog
- Transmembrane protein 231
- TMEM
Sequence:
MAYIFGFGDGILISFGIILVSIVLCILNGRSKGLSSVITYVIIAALFLATLFLWPIKSADEPTPIEQQKTDIVLIPRVVYLIFLPFFMIYLINLFVRHNLFNVVRTKSTVNRHGKPWLAEAKVKNS
Protein: Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) (P97363)
Organism: Mus musculus (Mouse)
Function: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity). Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:1317856}; Single-pass membrane protein {ECO:0000269|PubMed:1317856}.
Interaction partners:
- Serine palmitoyltransferase 1
- Serine palmitoyltransferase small subunit A
- 3-ketodihydrosphingosine reductase
- ORM1-like protein 3
- Serine palmitoyltransferase 3
- Serine palmitoyltransferase small subunit B
- ORM1-like protein 1
- ORM1-like protein 2
- Alanine--glyoxylate aminotransferase
- Cystathionine beta-synthase
Sequence:
MRPEPGGCCCRRPMRANGCVKNGEVRNGYLRSSTATVAAAGQIHHVTENGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRHWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGAKVDIMERKSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAEVLKEYGAGVCSTRQEIGNLDKHEELEKLVARFLGVEAAMTYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPSGRGVVDYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSMSPPVMEQIITSMKCIMGQDGTSLGKECIQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED
Protein: Syncrip, isoform F (A4V364)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAEGNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGKLDEIYKTGKLAHAELDERALDALKEFPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQQGVAAPATVKGPDEDKIKKILERTGYTLDVTTGQRKYGGPPPHWEGNVPGNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRLMMDPMTGTNRGYAFVTFTNREAAVNAVRQLDNHEIKPGKCLKINISVPNLRLFVGNIPKSKGKDEILEEFGKLTAGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRIKVWGCDIIVDWADPQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFEDRDSAVEAMRGLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMMQMMQARPGIVGNLSPTHPSIMSLTPMRPGARMPLRTPIPREYVVGKRKFDGGHQNPADVKRRYPSGLIGNGGSWGSLPLPQQPLGTNGEQWYMDTFSAWS
Protein: Homeotic protein ultrabithorax (P83949)
Organism: Drosophila melanogaster (Fruit fly)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein extradenticle
- Homeobox protein abdominal-A
- Homeobox protein abdominal-B
- Homeotic protein antennapedia
- Homeobox protein homothorax
- Regulatory protein zeste
Sequence:
MNSYFEQASGFYGHPHQATGMAMGSGGHHDQTASAAAAAYRGFPLSLGMSPYANHHLQRTTQDSPYDASITAACNKIYGDGAGAYKQDCLNIKADAVNGYKDIWNTGGSNGGGGGGGGGGGGGAGGTGGAGNANGGNAANANGQNNPAGGMPVRPSACTPDSRVGGYLDTSGGSPVSHRGGSAGGNVSVSGGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTFYPWMAIAGECPEDPTKSKIRSDLTQYGGISTDMGKRYSESLAGSLLPDWLGTNGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQAQKAAAAAAAAAAVQGGHLDQ
Protein: Mitogen activated serine/threonine protein kinase MEKK2 (Q8R4A9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
TSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYP
Protein: KH domain-containing, RNA-binding, signal transduction-associated protein 1 (Src-associated in mitosis 68 kDa protein) (Sam68) (Q8UUW7)
Organism: Gallus gallus (Chicken)
Function: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q07666}. Cytoplasm {ECO:0000250|UniProtKB:Q07666}. Membrane {ECO:0000250|UniProtKB:Q07666}. Note=Predominantly located in the nucleus but also located partially in the cytoplasm. {ECO:0000250|UniProtKB:Q07666}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein K
- Heterogeneous nuclear ribonucleoprotein K
- Proto-oncogene tyrosine-protein kinase Src
- Uncharacterized protein.
- Serine/arginine-rich splicing factor 1
- Heterogeneous nuclear ribonucleoprotein M
- Growth factor receptor-bound protein 2
- U2 small nuclear RNA auxiliary factor 2.
- Serine/arginine-rich splicing factor 2
Sequence:
MQRRDDSSARMGRGPGGPGSARQGGPNPRRSPRGGGGRGAGAQHPQPLLTGGAAAGSSGAQGPAAANPAPLLPGGAVKMEPENKYLPELMAEKDSLDPSSTHAMQLLSAEIEKIQKGETTKKDEEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPTRGRGGPVRGRGAAPPPPPPVPRGRGVGPPPPPPPPRGALVRGAPVRGAIARGAAVARGVPPPPAVRGAPAPRARAAGIQRIPLPPPPAPETYEEYGYDDAYADQSYEGYEGYYSQGQGDTEYYDYGHGEAQETYEAYGQDDWNGTRPSLKAPPARPVKGAYREHPYGRY
Protein: MKIAA1454 protein (Q69ZJ3)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
RMMASFQRSNSHDKVRRIVAEEGRTARNLIAWSVPLESKDDDGKPKCQTGGKSKRTIQGTHKTTKQNTAVECKITSTTGEKHFDKSPTKTRHPRKIDLRARYWAFLFDNLRRAVDEIYVTCESDQSVVECKEVLMMLDYYVRDFKALIDWIQLQEKLEKTDAQSRPTSLAWEVKKMSPGRHVIQSPSTDRMNVTSTARRSLNFGSLPGAVTAPCLAPTGVSWADKVKAHHTGSAPPEATPAQSCAPMTVQKTSRKNERKDAEGWETVQRGRPVRSRSTAVIPKVSLVTETLRSKDDSDKENICLLPEESIQKGKLEDRCSTVESLSKDSLLHSSDHPLSERTQFTVCILDDVKNSGSSQDSSVHTSEIPAIDSDAVCVAPQNTTALPTDRVPAETTGMVTEMTDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSLSFCGVSLDWNDVLADYEARESWRQNTSWGDIVEEEPARLPGHGIHMHEKLSSPSRKRTIAESKKKYEEKHMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHASTDYAPKLTPYERKKQCSLCNVLIASEVYLFSHIKGKKHQQAVRENSSIQGRELSDEEVEHLSLKKYVVDIVIESAAPPEPVKDGEERQKNKKKAKKIKARMNIRAKEYENLVETKNSGSESPYKAKLQRLTKDLVKQLQVQDSGSWVNNKASALDRTLGEIARILEKENVPDQISFQVAGGLTALENILQVVTPATNMNTVSRIPPKSLCNAINVYSLACNNCSENCTDVLFSNKITFLMDLLIHQLTVYVPDENNAVLGRNTNKQVFEGLTTGLLRAGAVVFSCLIANRPDGNSRPATPKISTQEMKNKPSQGDAFNSRVQDLISYVVNMGLIDRLHGCFLSVQGPVDENPKMATFLQHAAGFLRGMCMLCFAVTGRSSSIFDNNHQDPTGLTAALQATDLAGVLHMLYCILFHGTISDAGTSPKDSYTQNTIQVAIQSLRFFNSFAILDLSAFQSVVGAEGLSLAFRHMASSLLGHCSQVSCESLLHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLITACHNNHQNKLILEQEMSCVLLATFIQDFAQTPGHVDNQSSSLKGKFQNPGNYLELANRFPQQAWEEARQFFLKKEKK