wanglab/gogpt-training-data huggingface dataset:
Protein: Anti-sigma factor antagonist (P71937)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MGLITTEPRSSPHPLSPRLVHELGDPHSTLRATTDGSGAALLIHAGGEIDGRNEHLWRQLVTEAAAGVTAPGPLIVDVTGLDFMGCCAFAALADEAQRCRCRGIDLRLVSHQPIVARIAEAGGLSRVLPIYPTVDTALGKGTAGPARC
Protein: Acyl-CoA-binding domain-containing protein 4 (Q8NC06)
Organism: Homo sapiens (Human)
Function: Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.
Interaction partners:
- Vesicle-associated membrane protein-associated protein B/C
- Vesicle-associated membrane protein-associated protein A
Sequence:
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVFCDSLEQLEPELSSGQHLEESVIPGTAPCPPQRKRGCGAARRGPRSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSSLTLSVRLE
Protein: Anti-sigma-F factor antagonist RsfA (Anti-anti-sigma F factor RsfA) (P9WGE3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Positive, redox-sensitive regulator of sigma-F (SigF) activity. When reduced binds to anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription.
Interaction partners:
- Multidomain regulatory protein Rv1364c
- Anti-sigma-F factor RsbW
- Anti-sigma-F factor antagonist RsfB
- Uncharacterized protein Rv1366
- Uncharacterized protein Rv1354c
- Uncharacterized protein Rv2240c
Sequence:
MNPTQAGSFTTPVSNALKATIQHHDSAVIIHARGEIDAANEHTWQDLVTKAAAATTAPEPLVVNLNGLDFMGCCAVAVLAHEAERCRRRGVDVRLVSRDRAVARIIHACGYGDVLPVHPTTESALSAT
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (E6EK18)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}.
Interaction partners:
Sequence:
MATIDGRPAQYGISLKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSIDSDKKPRAGQILWIRGLTRLQTQISVPVIGGELQERLIPVPYSKSNTDQAIRVVNAFRQGLDARYGDHTNTSLAEVLRKQTSLSKRLSETSSIEYADNIPDELTIPEIDVERLSSHSHTETAV
Protein: Exportin-1/Importin-beta-like domain-containing protein (Q38AK6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVERIVQILSVVYAAEDNGDRRRATFELHEVEEQMNSEEIVSIGTGLLAVTDRGAAVQAYGAVLLRNAVVSGRIPPSVVPYEELMTWYFNEPTLGRLLCADIVELLIECMVREWPESYPDLIARVCAPPTQLAQQPRKLHFLSSFIAHITSPHVGGVPVNRMKRLKKAIELYGRTILVEVIQALFDLYTQAGGAASNSCAPGTKESVTDCLMTVANATPCLPVHVWSEVGLTNTLSALVRWGPAAQEALAATTALLRCDRLSCAGESTAADSLRTELLNVALGSVDMWVAESNHGNIEEVVGLLHDSPDTLLQPAAPVAGRVCLLTLSIPSVLLASVACSIFRRLGDAAFTQINPLELLARLAVLVPKNKLHPCCGTCEGGMQISEHDFGTVEAFTQAFSEFRSLAAHVLTSVARIYPVVANQFMLQLVSNLSDSRGTEEDARTQCGFVTQRSDTFCNWEATQFLLYSLSESFKHSSEYVPQIINELVKREPEDMVIFPVYLNMLSLLWNCRDDTALGVWQGTMGIILKSLGNRYREVNDIDVVSARKRALTLLVTACSKHAKQLVLLGEPFLCQMERLLMFSSTSAMERTLLYEAIAAFTTALPEDEAQRRLQSFLDPVAKIMVDHTTNMCQNAFNDIIIGRTTAQRDEGYVIRDSINVFAGVLRRCKTLPYVVEAASSLVPSIMKLMEFAHNIDAKDLPPEYKTLFGTYNGDGGAASHLRSREGEGAGGRKSDVYRARKILLDIRLALYQVIGALSSFFSVEPLENMLQMLVCVTRLLPIHAMRQLLSHCLFPVASAQERLIPATLSVCTTFYMQRNRGASRAPEAEAVDGRQLFGLSKDIFAFIRQNVVDPKRLDGNPALCQIVVDVTLSVLESGVNIAEASRFISAIVSNGNDANRFSGTANAQMVDMALCAYRRMIDFAVRADESLLPPREREKLLVTLADTYVSQYPLYVTAMKDRYPQPQVDELNTHLTMMGRIDVKRRYFKEFLQRFAGQVCVDGGQEGDR
Protein: Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3) (P20815)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2. Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione. Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance. Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- UDP-glucuronosyltransferase 1A4
- UDP-glucuronosyltransferase 1A8
- UDP-glucuronosyltransferase 1A6
- UDP-glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase 1A7
- UDP-glucuronosyltransferase 2B7
- UDP-glucuronosyltransferase 1A10
- Cytochrome P450 1A1
- Cytochrome P450 2B6
- Cytochrome P450 3A7
Sequence:
MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
Protein: Protein odd-skipped-related 1 (XOsr1) (Q66JF8)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Transcriptional repressor (By similarity). Required for pronephric kidney development.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P86413}.
Interaction partners:
Sequence:
MGSKTLPAPVPIHPSLQLTNYSFLQAFNGLPVPAEHMPNLYGFSALHAVHLHQWTLGYPTLHLPRSSFSKVPGVSSLVDSRFQIPTFPLFPHMIHPKQESPNLSNKTKPRFDFANLALAATQEDHCKLGQMDDQGSPPTIGGLLDVTKLTPEKKPTRGRLPSKTKKEFVCKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHTQVKELKPSKIKC
Protein: Fork head transcription factor 1 (DNA-binding forkhead transcription factor for ribosomal proteins fhl1) (HomolE-binding protein) (HEBP) (O14270)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a transcriptional activator with a role in the regulation of mitosis. Required for the correct timing, positioning and contraction of the division septum.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Interaction partners:
- Zinc finger protein sfp1
- Protein STB3 homolog
Sequence:
MPVAEIKNATQQPSSTNRVQAYAKLEFEKFSFFVQTLQVTMGRKASNSSDCDVHLGDTKAISRQHAKIFYSFPNQRFEISVMGKNGAFVDGEFVERGKSVPLRSGTRVQIGQISFSFLLPEGSEEDGHLKETGITPLSLQQGKIAYSDEFGGKPTGSFHTVTSNQEKDLLFSHIKHESDLPLGLSPADTNISNATSIIEHPDAANAHTLASLNQPPKHLTVSPSSIQRLSPQPYVRPTSDERPIETDSSVSAPKVANHDEELKQGKSTSPSDTVLHPDLNGSPDTGDATQKPNLSYANLIARTLIANPNKKMTLGDICEWIANNWSYYRHQPPAWHNSIRHNLSLNKAFIRIPRRQNEPGKGSFWMLDPSYIDQFEGNFFRRTKKPTPSATPAAHPDTARENELAAIQTKGISAGKTEQLNPQKETSRSKTHTSRGENVEDRPQSLLQNGIQPIIMRDGKLALNPEFFKNANGEQQAPNEQAVQAISLLQQHINKQLGPAAANNPEQATAIANALAVALAQKLQKQQTQMQGPQQVQQQAKRRKAYTSQQLNPAPTAMPHPNITSPSPSISVTQRPAVNVGPPPYVRPSAPSKLPDTRQSIGDPLPPGAMANVSAGPSSVRSSSYNSTASESKSEITSHQNLHTIPINKPFTSDRPLYSSPNDTLERVETGNQGQRMNSIGNASSFSKRDIMENENGSFDTNAKNGNNVDDSSSVRGMNLPSNSSDALRGVKRPLDETSSSYT
Protein: Reverse transcriptase domain-containing protein (Q9GZI7)
Organism: Caenorhabditis elegans
Interaction partners:
- PHD-type domain-containing protein
- Tudor domain-containing protein
- 3'-5' exonuclease eri-1
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 8
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 2
- Transcription-associated protein 1
Sequence:
MQPVLVNSRPLRVKSHESESKLNLIEQEDQFEGANYSSSSGVIICYSNGTGEVITQEAFDDSGIHFIFSKATCIQYPSNFDPIGVGSVVQIFWSRSFERVVRGNHIIVQIEKMEVYKCCAMLREQVFVTFNSPSTAGVAIGVTERNITVAFHPNCSPVIRYETLKAHSIGRTEFEIKDRHRENTNRMVDVILAAVPFRVEIHGNVDKIPFFVIEKCRNSPGRSGAAVITKIMKNHFMEANFLQNSESIYFDSTSCHSNILEKVSIGSLINVLADPTFATSSYKWYGYDVTLCNNYLAHASTQRSFVLENNEILQNCKKLEKSPEEAETTTKNDLRFVPPQPEKGEVKKKKMTNCLKFNSKSAQFKLRHLILDRCFSELPEREAKSIINSYFIDRLAEGIKIEKIDKNWRTFGEILPKTPKKYSESLKKSIQNVLEPFGLNKPEKAAETPKIVEYFPKNPKKRVEIVEKPTVDEIRELFGALMDAEGFALNQRVKPHFVLPDTRWKPTERRYIGIYDDVQWTFMSTFCPKIEENSENRPLAGGWWYRRTVPRDHPVEIVQKMETRRNIIKDCTESPFIE
Protein: Transcriptional repressor protein YY1b (YY1 transcription factor b) (Q7T304)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- E3 ubiquitin-protein ligase RING2
- Lethal
- MBT domain-containing protein 1 isoform X1
- Enhancer of zeste 1 polycomb repressive complex 2 subunit.
- Histone-lysine N-methyltransferase EZH2
- RING1 and YY1-binding protein B
- Mothers against decapentaplegic homolog.
- Mothers against decapentaplegic homolog
- Ubiquitin carboxyl-terminal hydrolase BAP1
- Polycomb protein eed
Sequence:
MASGETLYIEAEGAAVPAELVELQEIEVETIETTVIGGEDEDEDEEEPAMIALQPLHTGDGEPGVILLQTREEVVGEDAELRGDAFEEQILIPVPTPGADAQYIGQTLLTVAGRSSGGRAGRRAAAGGKKTGKKSYLSAAESSGRKWEQKQVQIKTLEGEFSVTMWASDDKKELEHEVEEHIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPKKIKEDDAPRTIACPHKGCSKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ
Protein: LD23533p (Q8T069)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDKSRSSAYDKFVGFVEQLRNTECSQKQKITCFQQIAECIMSPSLAGHINYAAHCGTATNVLLLFCEDVDSVVRMSAEENLNKILRSLEKTRVSRILMDLYGEIKRNGNQRSLRICLNLFSYYAPQIKEKHIKWYAVRLLQCMTTISQRKETLLQETLCDFVKHFSRHIQQGLSDSESCKLFETFLDQISSDCAVKRRCSAQNCMSLIENARNRSLMARHGVNKVMELLLTDQQANSVLGALGLLRLLLPQLIRGYPGDSHEDSESLAGKKQQQQQTTTSDCRQIIEIYDYCLHLLSTQHTANHAIINATLEVINGILQAVDAASDGQCSQSLGQSLRQLLCNQQLQHNEYLRRRKSLKNQIFQLKNYEVATSQHQLEDEDENEDVDELVVGATAMQMKKNSNAKLQQAKCREQQQHQHQQQLEVDNSSLGINAGEDAPTEAPSSVADEGGEPESTKLRCHIRNAARSISECVASDEDKQGQGHRQQRDEDGVVVAEDDDDDDDDDDDDDDMELLSAECDDFTTLSQLNEQQQALSAALKLPTTTAASSGGAATSQDDKLIDVDADVGGLPKPQHQSSLQNLLAGSDDKSQHLSDIDNESFNSIDFDAEITIAGSKEQQQ
Protein: MADS-box protein AGL72 (Protein AGAMOUS-LIKE 72) (Q9FLH5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: MADS-box transcription factor that acts with AGL42 and AGL71 in the control of flowering time. Promotes flowering at the shoot apical and axillary meristems. Seems to act through a gibberellin-dependent pathway. Interacts genetically with SOC1 and its expression is directly regulated by SOC1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
Sequence:
MVRGKIEIKKIENVTSRQVTFSKRRSGLFKKAHELSVLCDAQVAAMIFSQKGRLYEFASSDIRNTIKRYAEYKREYFVAETHPIEQYVQGLKKEMVTMVKKIEVLEVHNRKMMGQSLDSCSVKELSEIATQIEKSLHMVRLRKAKLYEDELQKLKAKERELKDERVRLSLKKTIYTHLCQVGERPMGMPSGSKEKEDVETDLFIGFLKNRP
Protein: Phosphatidylserine decarboxylase proenzyme 1, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase 1 beta chain; Phosphatidylserine decarboxylase 1 alpha chain] (O14333)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Together with psd2 and psd3, responsible for the majority of phosphatidylethanolamine synthesis.
Subcellular location: [Phosphatidylserine decarboxylase 1 beta chain]: Mitochondrion {ECO:0000305|PubMed:16823372, ECO:0000305|PubMed:34818062}. Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208}.; SUBCELLULAR LOCATION: [Phosphatidylserine decarboxylase 1 alpha chain]: Mitochondrion {ECO:0000305|PubMed:16823372, ECO:0000305|PubMed:34818062}. Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208}. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain. {ECO:0000255|HAMAP-Rule:MF_03208}.
Interaction partners:
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10
- Phosphatidylserine decarboxylase proenzyme 3
- Phosphatidylethanolamine N-methyltransferase
- Lysophospholipid acyltransferase
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- Phospholipase D1
- Phosphatidylserine decarboxylase proenzyme 2, mitochondrial
- Triacylglycerol lipase ptl3
- Putative phosphatidate cytidylyltransferase
Sequence:
MLKFHRNVKPQFGAFARYSSLGKHNSRKRVGIIRLAYGLTGIGLVGLAGFAWAQDRHEKTYQKKGVQVEGPWQFYVLTTLPLRTLSRWWGYVNRIEIPLWMRVPAFGLYSKIFGCNLTEADPDDVRQYKNLAEFFTRKLKPGARVIDPDAPIVIPADGKILNYGVIEGGQLEQVKGITYSLDALLGDEKLARLKRSHAIPSPDHIPHIRQEEFAKLNGIHYSLQDLMGHDHGERPSHVKDASAQHIDLLSSTKVAAKSQFTLFGSRETNCLYYAVIYLAPGDYHRFHSPTDWVVERRRHFSGELFSVSPFMARRLGNLFILNERVALMGRYKYGFMSMIPVGATNVGSIRIKFDKDLCTNQFGKLGPVGTFDEAVYTSSSSILHGHPLLRGDEVGNFELGSTVVLVFEAPADFEFLVKQGQKVRVGLPLGRVVPSSH
Protein: Short-chain dehydrogenase, putative (Q57YP2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHLVRKGRVALGASIVGTLRFQADKVSIFRHHSTTTPSPRTTQPKMHTLSENKADASAYAFGDDLANYSSLRHNFYLLLHGRRMWLPLVMLGIYNVLAPLYLTTWITNALYWSGCILLQRYSVRGRMNRLRKDFTDHVCVVTGGTSGIGLYTAMQLWEMGAHVVVASRPGKETETREFIRKNCRLPKESEEDTPLERLTFVSVDLSDQLEVMAAAARIKGMFDNRVDLLVNSAAVWREVPNATRKGLEEHIATNFLGPFHLTEALLPSLRRSRRGGRIVYVTCASHNGVRRADVVRERMTLKPSEDTQQLTARCYSASKLGNIYHVQSLAARRYEGIPLNTPSADLRPVDVCAVDPGFCATGHTWRESPPFLGTGLLGRALRSLWMKDGYEGSQTVVNCCVREDLESGGFYAACMCMPSGLSRRAHDSKSCREVMQWAMAKAIARYYTVRPRADNKGDTSSSVSNNLSKVSSAN
Protein: Oxidized purine nucleoside triphosphate hydrolase (EC 3.6.1.56) (2-hydroxy-dATP diphosphatase) (7,8-dihydro-8-oxoguanine triphosphatase) (8-oxo-dGTPase) (Methylated purine nucleoside triphosphate hydrolase) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1) (P36639)
Organism: Homo sapiens (Human)
Function: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.
Subcellular location: [Isoform p18]: Cytoplasm, cytosol {ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:7782328}. Mitochondrion matrix {ECO:0000269|PubMed:7782328, ECO:0000305|PubMed:12857738, ECO:0000305|PubMed:16607562}. Nucleus {ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:7782328}. Note=Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328). A very small amount of the protein is associated with nuclei (PubMed:7782328). {ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:7782328}.; SUBCELLULAR LOCATION: [Isoform p26]: Mitochondrion matrix {ECO:0000269|PubMed:16607562}.
Interaction partners:
- Adenine DNA glycosylase
- N-glycosylase/DNA lyase
- Aminoacylase-1
- ADP-sugar pyrophosphatase
- 8-oxo-dGDP phosphatase NUDT18
- Nucleotide triphosphate diphosphatase NUDT15
- Endonuclease III-like protein 1
Sequence:
MGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
Protein: Tryparedoxin (Q57WB2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Thioredoxin
- protein disulfide-isomerase
- Trypanothione reductase
- thioredoxin-dependent peroxiredoxin
- Glutathione peroxidase
- Glutathione peroxidase
- thioredoxin-dependent peroxiredoxin
- Thioredoxin-like protein
- Monothiol glutaredoxin, putative
- Glutathione peroxidase
Sequence:
MSGLTKYLPGATNLLSKSGEVSLGSLVGKTVFLYFSASWCPPCRGFTPVLAEFYEKHHVAKNFEVVLISWDENESDFHDYYGKMPWLALPFDQRSTVSELGKTFGVESIPTLITINADTGAIIGTQARTRVIEDPDGANFPWPN
Protein: Phosphoenolpyruvate carboxykinase (ATP) (EC 4.1.1.49) (P10963)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Fructose-1,6-bisphosphatase
- Pyruvate carboxylase 2
- Pyruvate carboxylase 1
- Pyruvate kinase 1
- Malate synthase 1
- Malate dehydrogenase, cytoplasmic
- Malate dehydrogenase, mitochondrial
- Isocitrate lyase
- Malate dehydrogenase, peroxisomal
- Acetyl-coenzyme A synthetase 1
Sequence:
MSPSKMNATVGSTSEVEQKIRQELALSDEVTTIRRNAPAAVLYEDGLKENKTVISSSGALIAYSGVKTGRSPKDKRIVEEPTSKDEIWWGPVNKPCSERTWSINRERAADYLRTRDHIYIVDAFAGWDPKYRIKVRVVCARAYHALFMTNMLIRPTEEELAHFGEPDFTVWNAGQFPANLHTQDMSSKSTIEINFKAMEMIILGTEYAGEMKKGIFTVMFYLMPVHHNVLTLHSSANQGIQNGDVTLFFGLSGTGKTTLSADPHRLLIGDDEHCWSDHGVFNIEGGCYAKCINLSAEKEPEIFDAIKFGSVLENVIYDEKSHVVDYDDSSITENTRCAYPIDYIPSAKIPCLADSHPKNIILLTCDASGVLPPVSKLTPEQVMYHFISGYTSKMAGTEQGVTEPEPTFSSCFGQPFLALHPIRYATMLATKMSQHKANAYLINTGWTGSSYVSGGKRCPLKYTRAILDSIHDGSLANETYETLPIFNLQVPTKVNGVPAELLNPAKNWSQGESKYRGAVTNLANLFVQNFKIYQDRATPDVLAAGPQFE
Protein: NADH-ubiquinone oxidoreductase chain 1 (EC 7.1.1.2) (Q2F9A3)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000471}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
TYIAVPAEILCLILPLLLGVAFLVLAERKVMAFVQRRKGPDVVGSFGLLQPLADGLKLILKEPISPSSANFSLFRMAPVATFMLSLVAWAVVPFDYGMVLSDPNIGLLYLFAISSLGVYGIIIAGWSSNSKYAFLGALRSAAQMVPYEVSIGLILITVLICVGPCNSSEIVMAQKQIWSGIPLFPVLVMFFIPCLAETNRAPSDLPEAEAESVAGYNVEYASMGSALFFLGEYANMILMRGLCTSLFPGGWPPILDLPISKKIPCSIWFSIKVLLFLFLYIWVRAAFPRYRYDQLMGLGRKVFLPLSLARVVPVSGVSVTFRWLP
Protein: Cyclin-L2 (Q5I0H5)
Organism: Rattus norvegicus (Rat)
Function: Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q96S94}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q96S94}.
Interaction partners:
- CLK4-associating serine/arginine rich protein
Sequence:
MAAAAAGASGLMAPALAACSSGSGGAAPGSQGVLIGDRLYSGVLITLENCLLPDDKLRFTPSMSSGLDIDTETGLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRHLREKKKPVPLVLDQEYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTAWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICFKILQLYTRKKVDLTHLESEVEKRKHAIEEAKARAKGLLPPGSAPGLDSATAGFSPAPKPESPKEGKGSKSSPLSVKNAKRKMEGPKKAKGDSPVNGLLKGQESRSQSRSREQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSPPRQVHRGAPYKGSEVRGSRKSKDCKHLTQKPHKSRSRSSSRSRSRSRERTDSSGKYKKKSHYYRDQRRERSRSYERTGHRYERDHPGHSRHRR
Protein: Large ribosomal subunit protein mL53 (54S ribosomal protein L44, mitochondrial) (YmL44) (P19956)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein mL54
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein mL61
- Large ribosomal subunit protein mL41
- Small ribosomal subunit protein uS19m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein mL46
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein mS37
- Large ribosomal subunit protein uL15m
Sequence:
MITKYFSKVIVRFNPFGKEAKVARLVLAAIPPTQRNMGTQIQSEIISDYNKVKPLVKVTYKDKKEMEVDPSNMNFQELANHFDRHSKQLDLKHMLEMH
Protein: Rap1gap protein (Q5EB70)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
DDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLLIPGKSASRFGRRGSALGIGAVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGMESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDAVKSGDPACPEIKIQLETSEQHTPQMGC
Protein: Protein MC014 (Q98185)
Organism: Molluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Subcellular location: Host nucleus {ECO:0000269|PubMed:26041281}.
Interaction partners:
Sequence:
MGVSLATRKYWPARTREGGCLRWEPVPAGQDLSCSLCDSLRVDMFLVVEPRRGLTRAGRGCECVRAGKRSLRGLARWPGAGAGGSAAFRACKTRHLLQREKCAVGRERRFCLWSGRHPKAPPGGRSRVRAHPGSDRVTAWLTGRRNS
Protein: NUDIX hydrolase, conserved (EC 3.6.1.-) (Q583R7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPNETAGKPPKVFQTNGKLPRGSDPTCDDVEFTHEGEVVVTSSDGKKFRRSVCVFIMNENGHFLGCRRYDDRSTIQCVQGGAKRGETVQQTATREVMEEIGVHCDQLQFISEITYSKPECGEPQNCDGPRSAFRYKSKSWRRIGIVGQELYPLLYSMQSSVINHLNFHSVPGTRREFIGAEWVPLHVLRNKCSKSKQVAVSNMCDAVEEILWGQSRSPRRDSHSADAGRLNELKKDIGSSSQHELGDTMNDMVNSCQRKRRRKRKGKSGNKNQLLHEEGGSLQMNLLGNPTSCE
Protein: Serine/threonine-protein kinase ppk1 (EC 2.7.11.1) (Q9HFF4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- SWIRM domain-containing protein laf2
- Oxysterol-binding protein homolog C2F12.05c
- Protein kinase domain-containing protein ppk2
Sequence:
MNAQPFHNNTSDVQSFQDIISNSYQKPLSLVDSTDRALPDSSLSSLSRSTFQFHKHHLSGNENPQPSSESPYFTNNERLNSSSFPQIHDNQLSPSFNTSYQAIPSSSSNRSRGGPYTPSIRDDSLLALLSFSSNHRLHSMPSQLQPFNNASSYTTPMAPFTASFSNKVSHSAYPTRRLPSQAKKTSAIERVPVNLNFLQSDNLVVQSSPQTNFENFEFPKKIPSKEDLETREVLLLPPQTSKLSNKNLDTKSFTDVNKISQQGFVEISSNSSKVTPNTSLHQSFGIASSSSNNYMQTSSELTSSTEKMNGSHPLQLSNKSLLSIHLMQSKNQGHVSMTGSDKLSSHVQSETENAPVSKPSKPNTLTEDEKPLQSTKLPGNSLTVGELYQEPKSIQLPELSVSRTTYSAQSSSVKNCNERIPSAKALKKQKHLVPENKSKLQYVWQKKESLPYANLTSASNTHFFLSENQNDTSERLTRTLRKSTKNYTFGSYILGRTIGTGEFGKVKLGWPLPKANSTIHRSTPQVVIKIVLSTKQNCQTSRLMREVAILKGLGNNHPHIVKYLDFVKTKHHFGIVLDYVNGGELFDYILARRRLEDSVACRLFAQLISGVAYLHSRGVVHRDLKLENILLDTNRNIVIADFGFATTFGHFNTLSEHSLPTEKPDLFSTSCGSPCYAAPELVNCKSGMYAGTQADIWSCGVILYAMLAGYLPFDDDPHNPNGENVPRLYRYICSTPLIFPEFFKSKARDILKKILVPDPAKRVRMSAIMNHAYLRSHVSLFETYNDDEATSLRPSPIRLLSQKSLASVSSVSSISTYSSSIELTPQITKTSLNREKPALHGSINLKHSTRPVVPIADGIYASTTLHPIDNAKNRLVSLLRRPKHKVKHAKVETRESPMKNKPTKKQHKRAFSMFERPTSQKAPLSPVESKINLMVAPKRVLNCASDSLRALLAGKTDKSFWGSRIPFLFNKLKSKQKAVSSSFNTENSFLILQAVSPLTFGGCFKEENAYGQKKQHMRHATVF