wanglab/gogpt-training-data huggingface dataset:
Protein: Kinesin-like protein (A0A178V0W2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKSPAILSENRFLGSITSSSIRNLLPKSISGKQKPIIQNPDTKIPRSNDENAIPVDPNQKASDHHTALQFTKQSDSKDGNFGEPIKDNKMGQSTFAEDKRSLLDSPLKVESRSILSRRTNSVPSEIKEEDDDDSLGDQIRELKEELIRTKSDGYNKADASKSGHFARDSLSQLRVSINKSLLMSCPKRDESEGKEVIVDGEDVLELNKHIEKLHGSYDSVHSSFASASCYEADSMSGDDEDVCSEDLEKPMHGNHKDVDFVDNDPSQLDNVEFDTTGSGISIRSQLPSCVLEEPIFSESPKFKNVQKSVAASTKFSANPRNVSESSNIGDMKVNQISPCMSKKVSGPTDSLAASLQRGLQIIDYHQGSSLSKSSSVSFSFGHMALKPCAEGENLNASVQSFRKDKASEGGLSSILLCLSCRKKVDQEAEVTEEAGSNEKHLKNMCMEQAAKIEELTLLLRKSDDGEDGTEFIKETYETKQISEEFGKTNFEVSEKEALLKEIADLKSKLQPTKSTDNLRSSLLLRSIQMRKSIDVSRNGENSDDLAKEREMWTEMESEWISLTDDLRMDIDNHRSRAENLEFELKQEKLATEELNDALTRAVLGHSRFIEQYTELQETYNELGEKHSVMMAGITDVKKAASKAAMNGRHGKRFAKAFSDELSAIRAEKEKERELLKKENKNLRTQLRDTAEAVQAAGELLVRLRESEQALQVSEERFSVVEEEKERLKKQMEQLKSKHKTEIGTMKQYLAESKLPGSALLQPWYKDEEDEIEQVSEHETGAVSFDDYEDDQAWRAEFGATYQDHHY
Protein: Cell division protein ZapA (Z ring-associated protein ZapA) (P94542)
Organism: Bacillus subtilis (strain 168)
Function: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Note=Localizes at mid-cell. In sporulating cells, localizes near the cell poles (By similarity). {ECO:0000250}.
Interaction partners:
- Cell division protein FtsZ
- Cell division protein FtsA
- Cell division protein SepF
- Septation ring formation regulator EzrA
- Probable peptidoglycan glycosyltransferase FtsW
- Uncharacterized transmembrane protein YshB
- DNA translocase SpoIIIE
- Cell division protein DivIB
- Cell division ATP-binding protein FtsE
- Cell division protein FtsL
Sequence:
MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREINEKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD
Protein: Zinc finger protein sfp1 (Q9UTH8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Protein STB3 homolog
- Uncharacterized Rab geranylgeranyltransferase C15C4.03
- RNA polymerase II subunit A C-terminal domain phosphatase ssu72
- Fork head transcription factor 1
- mRNA cleavage and polyadenylation specificity factor complex subunit pta1
- Cell cycle transcriptional repressor whi5
- HMG box-containing protein C28F2.11
- Set1 complex component swd2
- Uncharacterized WD repeat-containing protein C824.04
Sequence:
MPSLALPINKPSHHNVNYNGNSFNSIHATSFGMSPQSWGNSFSGQAWLRDTIPSLSNVVESQTIPEEDSTSYLNRLEEAFCRDFRCCGQTLEDLHQLIHHYEEQHAVLATDSAVPQEYSLDSNNAAQSNHSHIQALKQRERIRMHDLADQLGTSEISDNSAVLPFAFPANGGAPGPYRVSVVVPAAAAAAAAAASSDMSSDEASSQAETTGTPKKMPESLVMDASSPLSDMSMSIDVGESAANNVFAFNQKDMVDSTYLPPFNYDHDVFSFAPSVASADQFTESSMSPTPEVVSPAATNSAISSPFVRKSSSDLEAKPSKKQRSTPAFSHDSPLTIDYPGSNLVVVDKPYKCPVPNCDKAYKNQNGLKYHKLHGHCSPITTPTPAPIPHQGFVVENKPYRCEVCSKRYKNLNGLKYHRTHSHLQVSMAQAQREVQMNFMRTA
Protein: Chronophage, isoform J (A0A023GPJ3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDRDAEEGRPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPPSPADLLADGASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSSCEMEEQQDRQDKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKRPKMELVDAEANTVHTEPSNYTCSTCKTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGLASPQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIGSPQQQQLQLQQQQAQQQQQRVQQQQRENLASAMAAGMRHHPLLPPPEAMHANPFQLLRMPLPPALAQAGNVVPTVAPLFGRPSPADHYRMEQLVSEQFRHHGFNLAAAAAAAQAQFNANGQVVGGVVSGSGEPRPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQSQQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPGAGSTVNSSSPSPRQKQSPHFASPSPSQQQQQQLATIPRPHSLTPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMRKCVVNQGKAAAAANAVAAAQAAQAAAQHIQAAAQQAQAVQAQAVQAQAAQQSQQQQQQLSPMGVVGYPPQFVSGHNLSLPGSVSGDNDSNASSSMTGVHPISLKEEA
Protein: Synaptophysin-like protein 2 (Mitsugumin-29) (Mg29) (O89104)
Organism: Mus musculus (Mouse)
Function: Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.
Subcellular location: Membrane; Multi-pass membrane protein. Note=Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum.
Interaction partners:
- Junctophilin-1
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Junctophilin-2
- Junctophilin-4
- Ryanodine receptor 1
- Junctophilin-3
- Triadin
- Calsequestrin-1
- Sarcalumenin
Sequence:
MSSTESPGRTSDKSPRQQVDRLLLGLRWQRLEEPLGFIKVLQWLFAIFAFGSCGSYSGETGALVLCNNEAKDVSSIIVLFGYPFRLYQVQYEMPLCDQDSTSKTMNLMGDFSAPAEFFVTLGIFSFFYTMAALVIYLRFHKLYTENKRFPLVDFCVTVSFTFFWLVAAAAWGKGLTDVKGATRPSSLTAAMSVCHGEEAVCSAGATPSMGLANLSVLFGFINFFLWAGNCWFVFKETPWHGQGQDQGQGPSQESAAEQGAVEKQ
Protein: RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) (Hexaribonucleotide-binding protein 1) (Q9NWB1)
Organism: Homo sapiens (Human)
Function: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Ataxin-2
- RNA-binding protein 24
- Methyl-CpG-binding protein 2
- RNA-binding protein with multiple splicing
- Ataxin-1
- Heterogeneous nuclear ribonucleoprotein A/B
- RNA-binding protein Nova-1
Sequence:
MNCEREQLRGNQEAAAAPDTMAQPYASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVPEHTLNLYPPAQTHSEQSPADTSAQTVSGTATQTDDAAPTDGQPQTQPSENTENKSQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKTVNPYTNGWKLNPVVGAVYSPEFYAGTVLLCQANQEGSSMYSAPSSLVYTSAMPGFPYPAATAAAAYRGAHLRGRGRTVYNTFRAAAPPPPIPAYGGVVYQDGFYGADIYGGYAAYRYAQPTPATAAAYSDSYGRVYAADPYHHALAPAPTYGVGAMNAFAPLTDAKTRSHADDVGLVLSSLQASIYRGGYNRFAPY
Protein: Zinc finger AN1 domain-containing stress-associated protein 12 (AtSAP12) (Q67YE6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in environmental stress response.
Interaction partners:
- Eukaryotic aspartyl protease family protein
- At2g31940/F20M17.2
- Zinc finger A20 and AN1 domain-containing stress-associated protein 10
- Helicase with zinc finger protein
- Zinc finger A20 and AN1 domain-containing stress-associated protein 5
- TolB protein-like protein
- At2g41380
- Protein HYPER-SENSITIVITY-RELATED 4
- Cell division control protein 48 homolog D
- General transcription and DNA repair factor IIH subunit TFB1-3
Sequence:
MAGGGTEAFPDLGEHCQDPDCKLLDFLPFTCDGCKLVFCLEHRSYKSHNCPKSDHGSRTVSICETCSIAIETTGFDEKGIKSLLEKHERSGDCDPNKKKKPTCPVKRCKEILTFANNLTCKYCGVKFCLKHRFPTDHVCNKKIINTAGTSSRWNERFMEALSLRNQKGCGRGSSVSSKSSPSVRSF
Protein: Protein 4.1 (Band 4.1) (Erythrocyte membrane protein band 4.1) (D4A9A6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTEKSLAAEAENSQHQKEEGEGATNSGQQESQLEEASQAAAAEGSNQGEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLLSSFLKRPKSQVSEEEGREVESEREKGEGEQKETELGTSLDEDVILKAPIAAPEPELKTDPSLDLHSLSSIETQPAQEEHREDPDSETKEGEGIEECSGTEVKEDPESRAEREPETSQKPIRRHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAVWDSTTSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTVQSELGDYDPELHGVDYVSDFKLAPNQTRELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTLPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAAESTDRSPRPTSAPAIAQSQVMEGPGAPAKKAPKEAVKVEEKRGEEPAEPEPEPTEAWKVEKPHTEVTVPTSNGDQAQDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQVPTGDGPPLVKTQTVTISDTANAVKSEIPTKDVPIVHTETKTITYEAAQTEDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEISEE
Protein: Transcriptional cofactor Bfc (Booster for Crq) (Q9W0I5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000269|PubMed:34860835}.
Interaction partners:
- AT07490p
- Protein dpy-30 homolog
- Protamine A, isoform A
- Salto, isoform A
- FI13205p
- Uncharacterized protein
- Cytosol aminopeptidase
- GH20441p
- AT22380p
- GEO12122p1
Sequence:
MRMDKSEKRSNLADNFLYMLEFMVDDLLITRPNLCAPEEYPTCTEITFRSVFLNIRDRENGSCVNPCSPKCGKCTLFTLESPITDEDVMHIHVYKKRTESCKFLLGLTELPMKPIFDRVKKEFYSQNINWESNVESHLSRMPKLRGPCKKANDCVCYERNRERREQWCPTSELTKRMLPLFNLCKMQTGNIVLILRLVCNGPSVVSSFPVQRPVCKDPCNCCCPCPPTWPAPCSSPFDPCDPCKTVPAKKT
Protein: JNK1/MAPK8-associated membrane protein (JKAMP) (JNK1-associated membrane protein) (JAMP) (Medulloblastoma antigen MU-MB-50.4) (Q9P055)
Organism: Homo sapiens (Human)
Function: May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18784250}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dual specificity protein phosphatase 10
- E3 ubiquitin-protein ligase RNF5
Sequence:
MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH
Protein: Proline-rich AKT1 substrate 1 (Proline-rich AKT substrate) (Q9D1F4)
Organism: Mus musculus (Mouse)
Function: Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:14973226}. Note=Found in the cytosolic fraction of the brain (PubMed:14973226). Colocalizes with cortical neurons following ischemic/reperfusion injury (PubMed:14973226). {ECO:0000269|PubMed:14973226}.
Interaction partners:
- Serine/threonine-protein kinase mTOR
- DEP domain-containing mTOR-interacting protein
- Regulatory-associated protein of mTOR
- Target of rapamycin complex 2 subunit MAPKAP1
- Target of rapamycin complex subunit LST8
- Rapamycin-insensitive companion of mTOR
- GTP-binding protein Rheb
- TELO2-interacting protein 1 homolog
- RAC-alpha serine/threonine-protein kinase
- Peptidyl-prolyl cis-trans isomerase FKBP8
Sequence:
MASGRPEELWEAVVGAAERFQARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIAQAHRAATATRPPGPPPAPQPPSPAPSPPPRPALAREDEEEDEDEPTETETSGERLGGSDNGGLFMMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPTACPQPPATALPTQQYAKSLPVSVPVWAFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY
Protein: Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) (Gex-3-interacting protein 8) (Prion-like-(Q/N-rich) domain-bearing protein 12) (P34333)
Organism: Caenorhabditis elegans
Function: Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 9
- Uncharacterized protein
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 10
- SANT domain-containing protein
- Transcription-associated protein 1
- histone acetyltransferase
- Uncharacterized protein B0353.1
- Putative histone deacetylase 2
Sequence:
MESFKELAREYDEKFKAFQDDLQKWEETSERKEYAEFHRVQAESEFPELKREREDRERWARAERIRGEDEKSMLAKEHADKKIRLGVAKIPRLLTESERKMDEFVERPGSILKDMKKEHRQSVLDRLEEWSPEERSLFKSRQADHVKIFHGLTEFFVDKTASDLVLFYYMNKKTEDYKKDFKPKKRVTKYKVGAFPSVEELAYFRMMPPLDFSSFPKNSLMCYFCCRTVNGIDLNGTFMPKEAYEIFAICPDEDRVVCSGCREEAAKLYKDNRCFGNRCSNQKKRANRVNRNIPLDFADFPVRTRAFIMDKLGSTRVAVKFCTPCKNALTRWINDVNNKEETIMAELLNYEGQVGWTDDEKTKLVTLINSSPTLDWVSISEGMNRRPNECKMQYDAMNGVKTQPMIEEVDEEDGNGQEEGGDALVNTPTTSSAAARRSGLARNAKKPVRTPRAPRSAGGRRTGGAVTRAQAVPKPVEDLGEEIDEMEIEDNDEDASRGSRGKDSKAPSDRDGSPADMEGDSPEGQDQDADQDQDQDQDVDEEEEEVIVRDIDSPVKTLLSPKILSGGHKPDFPPVPRIQKPSTSSQPPPPEPMDTKENESDDGEEDNDILEIDVDEPPAKRPTPTSSSSHLIGSSSVGGSERELGGRGLVQQQQQQQPQAQSAAPPVTVSTAAAATAERLVNATSPSPSVASQHLVPTETSTSVPPVTIVPPAIQQPVVVISGAAPQFTQQQTTHSPALIAQPIPQQLIPQRVSTPAQILTPTPVRPTAASTPSMDQFLGLFKQQQQQQQQQPQQSNLMQQLGNINPQFLALLLQQQQQQQQVQQAQVQAAQTQGSLTSGTPFQAQQRPDEALQKLFSSPEMLGTLLNAKYQFPQFPQAIQQNPLLMNAQHQLILQQQQLAMQHAQAQAAQAAQAQAAQAAQAQAQAQAEAKLKTQAAQAKAQADAQARVQTQQQAHLKAQAQAQYQMNRPQLIPASVQMPIGINTAYHQKSLTPSETSASATPPAHRPRAATTVGSKMPAGRSNVQEAELRTLKEELIKRIRLFRDRIAEDAHLKREEENIVTYTAQIQASRVQYNTEILGQMKQRYEQAAARRIEIVKELDEPAKFINGVQNKFNDFSVFKLDEIDRQTLHEILQRYAAEQKPDQLQQQQNDFHNLLRQNNIGIRQAQYPALQASPHQAAIIQHQQQQEAFKKLQQQHQDAQKRKLEAPVSSATPQVKRIALSQSSPVQRFSQHPNGTLPHNLAVVYQNKMPQDREKLLQEQQLNQYLFAAQQQHLQQQQQHHGTQPEQKSKRKSGIESITSMQGAPHRHIQLAGPSSSRIQSGRGVSPALSASRSVAPTISGAAGRSITAGTSGHSSTSDYNKELAERMNEVFKPTHPQLLQTKASAMNSNAVSPANTNNSDEIECVYQGPPKTPASIKRLQPTEGPRTLSGQRMKSILSVPAHQRRSSIPPVKTEDEAMECLSMMMYEEAKAPPSDRIVTKLISSSEAAAAANPSAKFSYLDIFNDVVKRDEERCQRMLQSTSVLQPSRELDAFLQQLQQNPQQYANLSAAEKLALQQYQIHSAHQKSQQQAQLQAAQQLQQQQQARPDHYEKFHLLRPNAEIVRPIPTTFSHFLNKATTSTVSSSASAPQFLQPPAAASIAAPTPISTPHAMPSPSVGVQTAPPTPQAVHHPVMPIIPGKPSSVNSNVSDVSSDDDDVRNPEKLPANRLPPLPGDKTAFRSVIDLRATGHVAVTKKIPVKYPLVVQAQNGIQPIKDYGPPCKNLVYEDLSDDE
Protein: Shugoshin-1 (OsSGO1) (E3VXF2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Plays a central role in chromosome cohesion during meiosis I by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for the timely assembly and maintenance of synaptonemal complex (SC) during early prophase I. Required for maintenance of centromeric cohesion before prophase II and correct segregation of chromatids during meiosis II. Has apparently no function in mitosis.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:21615569}. Chromosome, centromere {ECO:0000269|PubMed:21615569}. Note=Transfers from nucleoli onto centromeric regions at the onset of prophase in both mitosis and meiosis. AM1 is required for centromeric localization. {ECO:0000269|PubMed:21615569}.
Interaction partners:
- Nitrate reductase
- Nitrate reductase 1
- Nitrate reductase
- protein-serine/threonine phosphatase
- Os04g0589400 protein
- Small ribosomal subunit protein uS2c
- Os01g0220300 protein
- Os06g0255200 protein
- Os02g0102400 protein
- Os08g0513300 protein
Sequence:
MAAAAGAAARGGGVIPAGKGGSLRSPGKPVVLADITNTGRPNPTGSVHAIADVLKENAKLRHLLAERNKVIEVSRVELQKIRLALQAMQQKNLQLVQANSQMFAEINQGKDRIKLLQHELACTIAVLKVKGSELEKMSKTSNNQQNRAKILEKKTRSSKCAPTKAHQMAAGSIREHLVEIQSAVPSYTSCHEPPQDKTNKRCTNRRKSESCEVTMDTNTVQHSCRPHVEYNGSSHDDDPRKTRRRRSARLNPGSFEVAEICDKLHEDATVPSAPSSNVPKLQEPNAGKDMICGGKMKSLQKELPCDAIAQVVEAPELKEIQEAGSSVAGGEAHKFDIEDPEPPRKSMRIDANKRKLESFESRLASNKEDCINAICDSTSSVPIQHEQKRKLSRRKSSRLDPGPWEVTNGTFEIVQEDTVAPSAPSSSNALIEQTKNDMQNDRSCSTKPSDEQVIGRRSSVGRPSRRAAEKIVSYKEVPLNIKMRRP
Protein: Syntaxin 16 (D3Z9R7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Interaction partners:
Sequence:
MATRRLTDAFLLLRNNSIQNRQLLAEQVSSHTTSSPLHSRSIAALADDRMALVSGISLDPEAAIGVTKRSPPKWVDGVDEIQYDVGRIKQKMRELASLHDKHLNRPTLDDSSEEEHAIEITTQEVTQLFHRCQRAVQALPSRARRTCSEQEERLLRNVVASLAQALQELSTSFRHAQSDYLKRMKNREERSQHFFDTPVPLMDDGDDATLYGQGFTDDQLVLVEQNTLVVEEREREIRQIVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNVEQSCVKTEDGLKQLHKAEQYQKKNRKMLVILILVAVIVVLIVVLIAVKSR
Protein: Ankyrin 2 (A0A5F9ZGZ1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKELTEELGELEASSDEEAMVTTRVVRRRVIIQGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEVTLCEPSILSSTSQFQAEPVEGRRVSKVVKTTVVLGERMEKHLGDSSLATDLPSAKDDFEEDNNE
Protein: Cofilin/actin-depolymerizing factor homolog 1 (PfADF1) (P86292)
Organism: Plasmodium falciparum (isolate HB3)
Function: Not involved in actin polymerisation, instead functions to stimulate nucleotide exchange on monomeric actin and influence turnover of the small amount of cytosolic actin microfilaments. Essential for erythrocytic schizogony.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q03048}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q03048}.
Interaction partners:
Sequence:
MISGIRVNDNCVTEFNNMKIRKTCGWIIFVIQNCEIIIHSKGASTTLTELVQSIDKNNEIQCAYVVFDAVSKIHFFMYARESSNSRDRMTYASSKQAILKKIEGVNVLTSVIESAQDVADLK
Protein: Probable nitrite reductase-hydroxylamine oxidoreductase fusion protein (NIR-HAO) (EC 1.7.2.1) (EC 1.7.2.6) (P0DV45)
Organism: Kuenenia stuttgartiensis
Function: A nitrite reductase-hydroxylamine oxidoreductase protein that probably functions in the type 1 encapsulin nanocompartment. Probably involved in reductive catalysis. Targeted to the encapsulin nanocompartment by association with the diheme domain of the encapsulin shell protein (AC Q1Q6L7) (Probable). Catalyzes the reduction of nitrite to nitric oxide (NO) (By similarity). Catalyzes the oxidation of hydroxylamine to nitrite (By similarity).
Subcellular location: Encapsulin nanocompartment {ECO:0000269|PubMed:28263314}.
Interaction partners:
Sequence:
MLNKSAALVPVVLAFLFLFLCFQCLYADIRCLTGKDGAVHLEMEAKPLTIEPRPGVFFDAWGYCLKGDVPTVPGPVIKVREGTKVKILFRNKLTVPASIHPHGVKYTTANVGVNIAGNPASIVAPGDSRIFEWDTAGTPGTWFYHSYVFERGGEEGLSRGLWGALIVEPVGGDPNPPDKEFVVFMHAFNVNGQEYYAFNNKSGDIELMRGDSSAFPGETWKAKMGDKVRFHLINITEEAHTFHTHGHRWLDKSCDKLIDTIGLNPFDSYVLDFVAGEGVGKGNWAFHCQSQEHMMNGMFGIFMVEEGKRVNAVIASCDEGRKTLSAPGQDRQPPTLEGFSGAYMYPEITEKNMYESFAGLEKGDGIWGDYYSPIPLYTYFNPSRHYVPPESDAYTNLLVKYRPDQCVECHEETTPGIVAEWKMSNHANPKKNPHVSAETQEIEALIGKELNNWRPGTKDGVYCSYCHGSDHEKLFMPTVDNSCGACHPKQAAEFIKGRDHGRPNHPQSWEGNVSTPWYAEYYRRGEGYSMVGCDQCHQNMSSCDDCHSRHRFSAAEARRPEACSICHMGPDHPDWESYSRSKWGVIYETTKERWNWDKNLAEVIPGEDYLAPTCQYCHMYVGNNKWEMNVETKGIWRMGVIPPKEVEFKSGLKDFPYGIKIPPMDKKLEIYSAESQEKRRKWVELCSKCHSSRFAGMWLDSLDQYMFESWRRIDEAQLIIEKLFSENAIEPPPEKRPPFPLSDLIIKVLGAEKLGAEMYRLFKQTNGHLPVIGPILGAYSIFTQNEGNPGGIEREYAEMWFWSHLQGYKGAAHAQPDISWWWGTAQGVGNLTRIRDEAEKLRRLKSGSSSGF
Protein: Transcription factor protein (F6WD51)
Organism: Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Interaction partners:
- Transcription factor protein
- Transcription factor protein
- Stress-activated protein kinase JNK
Sequence:
MKLHMMTHGQSSTPARGRVSPYYIPQSYQSTYYNNGGSRKGSIHHNVASDSNVAVDLRQGRRSPDNQAEYKHRNMNNQQVYNDERSLSRMTTEDLLMVEEHIRPLIKEELRYTIQSKRIARGLPETVELEYKTQQNDEISPETLLKRERRRERNKVAAAKCRFKKKILSEQLQEESEHLENLNAKLKREIEKLQEERQKLMYLLNGHKPECIAVPEEINLDAEPQYMDKQSDPRFNTICSSAANAPDNDVQQNEHTAPKTIYPYDETYLTRRL
Protein: Synaptotagmin-3 (Synaptotagmin III) (SytIII) (Q9BQG1)
Organism: Homo sapiens (Human)
Function: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P40748}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Synaptotagmin-10
- Synaptotagmin-6
Sequence:
MSGDYEDDLCRRALILVSDLCARVRDADTNDRCQEFNDRIRGYPRGPDADISVSLLSVIVTFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLGPGVGLAGLVGGGGHHLAAGLGGHPLLGGPHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPSQTSPELPSEGGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKENSE