wanglab/gogpt-training-data huggingface dataset:
Protein: Protein elav (Embryonic lethal abnormal visual protein) (P16914)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism.
Interaction partners:
- GH05443p
- Bruchpilot, isoform J
- DNA-binding protein Ewg
- Fasciclin-2
- Actin-5C
- Neuronal synaptobrevin, isoform J
- Endoribonuclease Dcr-2
- Protein deadpan
- Beta galactosidase, isoform A
- Neuroglian
Sequence:
MDFIMANTGAGGGVDTQAQLMQSAAAAAAVAATNAAAAPVQNAAAVAAAAQLQQQQVQQAILQVQQQQTQQAVAAAAAAVTQQLQQQQQAVVAQQAVVQQQQQQAAAVVQQAAVQQAVVPQPQQAQPNTNGNAGSGSQNGSNGSTETRTNLIVNYLPQTMTEDEIRSLFSSVGEIESVKLIRDKSQVYIDPLNPQAPSKGQSLGYGFVNYVRPQDAEQAVNVLNGLRLQNKTIKVSFARPSSDAIKGANLYVSGLPKTMTQQELEAIFAPFGAIITSRILQNAGNDTQTKGVGFIRFDKREEATRAIIALNGTTPSSCTDPIVVKFSNTPGSTSKIIQPQLPAFLNPQLVRRIGGAMHTPVNKGLARFSPMAGDMLDVMLPNGLGAAAAAATTLASGPGGAYPIFIYNLAPETEEAALWQLFGPFGAVQSVKIVKDPTTNQCKGYGFVSMTNYDEAAMAIRALNGYTMGNRVLQVSFKTNKAK
Protein: Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (P24557)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8366093}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Prostaglandin G/H synthase 1
- Prostacyclin synthase
- Probable maltase-glucoamylase 2 pseudogene)
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
Protein: Peptidoglycan hydrolase P7 (Protein VII) (Q9XJR8)
Organism: Pseudoalteromonas phage PM2 (Bacteriophage PM2)
Function: Exolysin that catalyzes the cleavage of the host peptidoglycans during virus entry.
Subcellular location: Virion membrane {ECO:0000305|PubMed:12134022}; Single-pass membrane protein {ECO:0000305|PubMed:12134022}. Note=Part of the capsid inner membrane. {ECO:0000305}.
Interaction partners:
Sequence:
MINKTTIKTVLITLGVLAAVNKVSALRSVKRLIS
Protein: ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2) (P58428)
Organism: Rattus norvegicus (Rat)
Function: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG5 has ATPase activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9H221}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H221}. Apical cell membrane {ECO:0000250|UniProtKB:Q9H221}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H221}.
Interaction partners:
- ATP-binding cassette sub-family G member 5
- NPC1-like intracellular cholesterol transporter 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Cytochrome P450 7A1
- Sterol regulatory element-binding protein 2
- ABC-type oligopeptide transporter ABCB9
- Oxysterols receptor LXR-alpha
- Scavenger receptor class B member 1
- Hepatic sodium/bile acid cotransporter
- Sodium/potassium-transporting ATPase subunit alpha-4
Sequence:
MAEKTKEETQLWNGTVLQDASSLQDSVFSSESDNSLYFTYSGQSNTLEVRDLTYQGGTCLRSWGQEDPHMSLGLSESVDMASQVPWFEQLAQFKLPWRSRGSQDSWDLGIRNLSFKVRSGQMLAIIGSAGCGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQKCVAHVRQQDQLLPNLTVRETLTFIAQMRLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGVAQHMVQYFTSIGYPCPRYSNPADFYVDLTSIDRRSKEQEVATMEKARLLAALFLEKVQGFDDFLWKAEAKSLDTGTYAVSQTLTQDTNCGTAAELPGMIQQFTTLIRRQISNDFRDLPTLFIHGAEACLMSLIIGFLYYGHADKPLSFMDMAALLFMIGALIPFNVILDVVSKCHSERSLLYYELEDGLYTAGPYFFAKVLGELPEHCAYVIIYGMPIYWLTNLRPGPELFLLHFMLLWLVVFCCRTMALAASAMLPTFHMSSFCCNALYNSFYLTAGFMINLNNLWIVPAWISKMSFLRWCFSGLMQIQFNGHIYTTQIGNLTFSVPGDAMVTAMDLNSHPLYAIYLIVIGISCGFLSLYYLSLKFIKQKSIQDW
Protein: Transcription factor SMP1 (P38128)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor that controls part of the HOG1-mediated osmostress responses. Binds to the DNA sequence 5'-ACTACTA[TA](4)TAG-3'. Does not appear to function in the MPK1 pathway.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Mitogen-activated protein kinase HOG1
- High-osmolarity-induced transcription protein 1
- CRE-binding bZIP protein SKO1
- Transcription factor RLM1
- pH-response transcription factor pacC/RIM101
- Zinc finger protein MSN2
- Zinc finger protein MSN4
Sequence:
MGRRKIEIEPIKDDRNRTVTFIKRKAGLFKKAHELSVLCQVDIAVIILGSNNTFYEYSSVDMSNLLNVHQNNTDLPHNIIEPSDYGDYVKKPRVVLNERKRRRRRATVLQPASHSGSCTVSSQDSSSVQNNGNLSAPLASNDAGNAGVSTPLVHCHGAISRSGSNHSDCARNSADYQMLQGGLNSGGSFHANDYKESVDQQHVANEAIHRNFMNKRIRPDTHLLLSESNHSNYHNFYPSPYENLPKPSLPASLVGNIPSFQSQFVQVIPANSNPMGKGFNGTGDSESFEAKQKIHPTVAISNTLEGPAPVQAMVHHLHQLNSNRGKLSGKPYLKLNIPKATNDACQRSPAMYSGTASPKTDVQATPNQMLASNMSSPLSRSKFLGFKNNDMDDLYHNGRCGSTYVNNKTFFLKPPIGRPPKFPKSPSSSIVVFPSSVASSTLKSTSSTNSPD
Protein: Nuclear membrane organization protein apq12 (O94353)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the regulation of lipid homeostasis in the endoplasmic reticulum, thereby impacting nuclear pore complex biogenesis and localization, and nucleocytoplasmic mRNA transport.
Subcellular location: Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Nucleus export protein brr6
- Vacuolar import and degradation protein 27
- Nuclear bridge Ish domain protein les1
Sequence:
MSLTSVLWNFVAKLAVDHGLNTNPDQVFQTVENVGKSFEKYETSFLKSLFNGNLGLSLPSAINILTLIIVLYFSLVIVNKTTSIALALFKTLAVISFFLLIGCLFAYWFINNGSF
Protein: Probable protein phosphatase 2C 69 (AtPP2C69) (EC 3.1.3.16) (Q8LAY8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGYLDLALSYSNQPQTVEAPASGGGLSQNGKFSYGYASSAGKRSSMEDFFETRIDGINGEIVGLFGVFDGHGGARAAEYVKRHLFSNLITHPKFISDTKSAITDAYNHTDSELLKSENSHNRDAGSTASTAILVGDRLVVANVGDSRAVISRGGKAIAVSRDHKPDQSDERERIENAGGFVMWAGTWRVGGVLAVSRAFGDRLLKQYVVADPEIQEEKIDDTLEFLILASDGLWDVFSNEAAVAMVKEVEDPEDSAKKLVGEAIKRGSADNITCVVVRFLEKKSASSSHISSSSSKEAKEMPPLGDLAISSNEAKQVQIGSGNKPENVTNRKPDTASRSTDTLTLERNSVTDKV
Protein: N-methyltransferase vrtF (EC 2.1.1.-) (Viridicatumtoxin synthesis protein F) (D7PHZ7)
Organism: Penicillium aethiopicum
Function: N-methyltransferase; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system. The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA. The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB. The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone. The cyclization of the last ring could be mediated by the lactamase-like protein vrtG. The proposed post-PKS tailoring steps are an hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF. VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin. Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin.
Interaction partners:
Sequence:
MTTTTTTDDTQKLDPSASDEVIYKSWDLLIYEIWVLGIVSTWAWGCSTTEYLLPQFRANVGTNHLDVGSGTGYYLRKGGIPASTRLTLLDLERPALDLGLQRCGRSDARGLQADILQPLPVIDKFDSVSMYYLLHCIPASVEDKCAIFKHIKHNMTPDGVIHGANVLGKGVRNDGHFAAYVRRGVLKAGIFHNLDDNAYDFEHALRMNFEEVETRVVGSVFIFRASRPKLDEGDLLET
Protein: Synapsin-3 (Synapsin III) (O14994)
Organism: Homo sapiens (Human)
Function: May be involved in the regulation of neurotransmitter release and synaptogenesis.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
Interaction partners:
- Synaptosomal-associated protein 25
- Synaptotagmin-1
- Synapsin-2
- Disks large homolog 4
- Chaperone Ric-8B
- Vesicle-associated membrane protein 2
- Regulating synaptic membrane exocytosis protein 1
- Myristoylated alanine-rich C-kinase substrate
- Glutamate receptor 1
- Vesicular glutamate transporter 1
Sequence:
MNFLRRRLSDSSFMANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSLSSAMKQAPQATSGLMEPPGPSTPIVQRPRILLVIDDAHTDWSKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKVVSRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSKMSQLPMPGGTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQPQPRPPPQGGPRQAQSPQPQRSGSPSQQRLSPQGQQPLSPQSGSPQQQRSPGSPQLSRASSGSSPNQASKPGATLASQPRPPVQGRSTSQQGEESKKPAPPHPHLNKSQSLTNSLSTSDTSQRGTPSEDEAKAETIRNLRKSFASLFSD
Protein: lysoplasmalogenase (EC 3.3.2.2) (Q21552)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MQSQLSSIGLAYFLLVANFYYQSNGFNDHYTFSYSFWKITPIILLVAFAYLNGGGLGKEQRKTAAAGLFFGGVGDWIIGMRHDGIILGAVAFGIGHLFYLSLYRQHATKIHTKFLLGMLAWALVIGQLCFIPMLADHRGPLTVFASYSLLLSTCTLIAVSQYLNGSKSQNEEGLLYRAIGFFLFYISDSVLMLSHTGYWKLAPSFCVLSTYYSAQYFILFGNTMAVNPVKKSVKIN
Protein: Bcl-2-related protein A1 (Bcl-2-like protein 5) (Bcl2-L-5) (Hemopoietic-specific early response protein) (Protein BFL-1) (Protein GRS) (Q16548)
Organism: Homo sapiens (Human)
Function: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:34245648}.
Interaction partners:
- Phorbol-12-myristate-13-acetate-induced protein 1
- Bcl-2-like protein 11
- Bcl-2 homologous antagonist/killer
- BH3-interacting domain death agonist
- Bcl-2-modifying factor
- Heat shock protein HSP 90-alpha
- Bcl-2-interacting killer
- Activator of apoptosis harakiri
- Heat shock protein HSP 90-beta
- Peptidyl-prolyl cis-trans isomerase FKBP5
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
Protein: Sodium- and chloride-dependent betaine transporter (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12) (P27799)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:P31651}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P31651}; Multi-pass membrane protein {ECO:0000255}. Note=In kidney, locates in basolateral membranes of renal medulla. In liver, locates in hepatocytes cell membrane. {ECO:0000250|UniProtKB:P31651}.
Interaction partners:
- Amino acid transporter.
- Amino acid transporter.
- Amino acid transporter
- Solute carrier family 6 member 7.
- Transporter
- Amino acid transporter.
- Transporter
- Transporter
- Transporter
- Fibrous sheath interacting protein 1.
Sequence:
MDRKVAVPEDGPPVVSWLPEEGEKLDQEGEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFTCGIPVFFLEVALGQYTSQGSVTAWRKICPLLQGIGLASVVIESYLNIYYIIILAWALFYLFSSFTSELPWTTCTNTWNTEHCMDFLNHSGARTATSSENFTSPVMEFWERRVLGITSGIHDLGALRWELALCLLLAWLICYFCIWKGVKTTGKVVYFTATFPYLMLVILLIRGITLPGAYQGVIYYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFAAGFVVFSILGFMAQEQGLPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASMDMFPSQLRKSGRRELLILAIAVFCYLAGLFLVTEGGMYIFQLFDYYASSGICLLFLAMFEVICISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSQYTPLKYNNIYVYPPWGYSIGWFLALSSMICVPLFVIITLLKTRGSFKKRLRQLTTPDPSLPQPKQHLYLDGGTSQDCGPSPTKEGLIVGEKETHL
Protein: L-type lectin-domain containing receptor kinase S.4 (LecRK-S.4) (EC 2.7.11.1) (Q9M2S4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9LSR8}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- At3g52790
- Jacalin-related lectin 19
Sequence:
MSQTFAVILLLLIFLTHLVSSLIQDFSFIGFKKASPNLTLNGVAEIAPTGAIRLTTETQRVIGHAFYSLPIRFKPIGVNRALSFSTSFAIAMVPEFVTLGGHGLAFAITPTPDLRGSLPSQYLGLLNSSRVNFSSHFFAVEFDTVRDLEFEDINDNHVGIDINSMESSISTPAGYFLANSTKKELFLDGGRVIQAWIDYDSNKKRLDVKLSPFSEKPKLSLLSYDVDLSSVLGDEMYVGFSASTGLLASSHYILGWNFNMSGEAFSLSLPSLPRIPSSIKKRKKKRQSLILGVSLLCSLLIFAVLVAASLFVVRKVKDEDRVEEWELDFGPHRFSYRELKKATNGFGDKELLGSGGFGKVYKGKLPGSDEFVAVKRISHESRQGVREFMSEVSSIGHLRHRNLVQLLGWCRRRDDLLLVYDFMPNGSLDMYLFDENPEVILTWKQRFKIIKGVASGLLYLHEGWEQTVIHRDIKAANVLLDSEMNGRVGDFGLAKLYEHGSDPGATRVVGTFGYLAPELTKSGKLTTSTDVYAFGAVLLEVACGRRPIETSALPEELVMVDWVWSRWQSGDIRDVVDRRLNGEFDEEEVVMVIKLGLLCSNNSPEVRPTMRQVVMYLEKQFPSPEVVPAPDFLDANDSMCLDERSGSAGEFEDFVDSARFYSGPNETTTSSIFSFSGKTRTDPR
Protein: U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (A4QP06)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSLPKREVDELRPWVERTVKKVLGFSEPTVVTAALHCVGKGLDKRKTIDQLRPFLDDSASSFVERLFEALEESRNSRGSKGSGEKNRKRELKEVFGDEMEGVKDVVSVESAVKKKRVPRFEEVEEPVVLPGPPTESPGMLTKIQIKQMMEAATRQIEERKKQLSFAAPTPSSQSRLSASQTDSSTPRSMNQAGGATQSIAPSQAANFMNDAIEKARKAAELQAKIQSTLSMKPGILATVGNPGPHNMVALANLHAMGIAPPKVEPREITKPTPLILDELGRTVDASGKEIELTHRMPTLKANIRAVKREQFRQQLKEKPSDDLESTSYFDPRVALAPALKPKKGFRFHEQGRFEKIAQRIRTKAQLEKLQMEIAQAAKKTGIQASTKLALIAPKKELGEGEIPNIEWWDSYILPFHINLSAHTNLDEVEMHGVTNLVEHPTQMAPPVDTDKPVTLGVYLTKKEQKKLRRQTRREGQKEVQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQGPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKEKKVKKLKEDLSHGVHIAVYRIRNLHNPAKKFKVEANANQLYLTGTVVLHKDVNIVVVEGGPKAQKKFKRLMLTRIKWDEPNSKRDEHHDDDESRRNNRCSLVWEGTSKERNYGEVKFKQCPTENMAREHFKKHGTEHYWDLALSQSVLETTDD
Protein: Down-regulator of invasive growth 1 (Regulator of STE12 protein 1) (Regulator of sterile twelve 1) (Q03063)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DIG1 and DIG2 are negative regulators of the filamentation and pheromone induced mating program. DIG1 and DIG2 inhibit the transcriptional activity of STE12 by direct protein-protein interaction. DIG1 colocalizes to promoters with STE12 and redistributes with it during induction of filamentation (by butanol) or mating (by pheromone) to program specific genes, but binding of DIG1 to STE12 is reduced by pheromone treatment.
Subcellular location: Nucleus.
Interaction partners:
- Ty transcription activator TEC1
- Down-regulator of invasive growth 2
- Protein STE12
- Mitogen-activated protein kinase FUS3
- Mitogen-activated protein kinase KSS1
- Pheromone receptor transcription factor
- Serine/threonine-protein kinase STE7
- Nuclear fusion protein FUS1
- Protein STE5
- Serine/threonine-protein kinase STE11
Sequence:
MAVSARLRTTAEDTSIAKSTQDPIGDTEISVANAKGSSDSNIKNSPGGNSVGQESELEHVPEEDDSGDKEADHEDSETATAKKRKAQPLKNPKKSLKRGRVPAPLNLSDSNTNTHGGNIKDGNLASSNSAHFPPVANQNVKSAPAQVTQHSKFQPRVQYLGKASSRQSIQVNNSSNSYGKPHMPSAGIMSAMNPYMPMNRYIMSPYYNPYGIPPPHMLNKPIMTPYVSYPYPMGPRTSIPYAMQGGNARPYEENEYSASNYRNKRVNDSYDSPLSGTASTGKTRRSEEGSRNSSVGSSANAGPTQQRADLRPADMIPAEEYHFERDALLSANTKARSASTSTSTSTSTNRDRSSWHEAEPNKDEEEGTDLAIEDGAVPTPTFTTFQRTSQPQQQSPSLLQGEIRLSSHIFAFEFPLSSSNVDKKMFMSICNKVWNESKELTKKSSSHHRTGK
Protein: WbcN protein (Q56917)
Organism: Yersinia enterocolitica
Interaction partners:
Sequence:
MYEAGHNVMIISLTGETLVRPNDGIQLNELKLDKAPFSLFKGLFEVKKIIKKFKPDIVHSHMFHANLFARILRVFTKIPALICTAHNTNEGSSLRMLAYKYTDKLASLSTNVSQDAVDSFIHKGASSTGRMIAVSNGIDASQFDFSMDERKVKRSELGIFNDTPIILSVGRLTEAKDYPNLLTAFSLLIKDNSLQSFPQLFIVGTGHLDGYLKNMSKEFGIDKYVTLFGQRDDILQLMCAADIFVLSSEWEGFPLVITEAMACKKIIVATDAGGITEALGDCGSIVPIKDPNSLSQAINKMIKLSDNEKEILGNKARERIIQTNSIEKIIELGCLFILNLKNNC
Protein: Putative calcineurin B subunit (Q4QC21)
Organism: Leishmania major
Interaction partners:
- Putative serine/threonine protein phosphatase 2B catalytic subunit A2
- Serine/threonine-protein phosphatase
- Serine/threonine specific protein phosphatases domain-containing protein
- Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
- peptidylprolyl isomerase
- peptidylprolyl isomerase
Sequence:
MNEIPLTAEELQNIRESTALTDAQVQRLYKSFSKLNKDKSGKITRAEFNSIPALASNPLVDRVLAVMDTDGDSTVDFGDFVRALAVLSSATSKEDKLRFTFKMYDVDGDGRISNKDLFQMLSIMVGVNLSQMQLQQIVDKTFIEADVDRDGYITFEEFQALAVNSDFGDRLNLHF
Protein: DNA-binding protein HMf-2 (Archaeal histone B) (P19267)
Organism: Methanothermus fervidus
Function: Binds and compacts DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation in vitro.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:2377617}. Chromosome {ECO:0000305|PubMed:2377617, ECO:0000305|PubMed:7809089}.
Interaction partners:
Sequence:
MELPIAPIGRIIKDAGAERVSDDARITLAKILEEMGRDIASEAIKLARHAGRKTIKAEDIELAVRRFKK
Protein: GH11143p (Q8MR61)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
Sequence:
GSKMTYQGYKELLVEQQGKLLVAKFNNPKKKNCINRVAYQEMTRVLTEVNDDEGVTIVVFTGVGDIFTSGNDLSQSSNTDDIDAFFKQSNATFKAMVLSFVNCRKIVLALVNGPAIGIGATIVGLCDVAWCSETTYFYTPFTKLGLVPEGGSSYMLPLILGRSKASEILLLSEPLSAQEAYQFNFVSRIFKASELESVIWPKLRQYSELPTNSLLQGKRLVKDGFLENLIKANEAECKQLLQQFQHPEFAQAIIDFASRKNKAKL
Protein: Glucomannan 4-beta-mannosyltransferase 7 (EC 2.4.1.32) (Cellulose synthase-like protein A7) (AtCslA7) (Glucomannan synthase) (Mannan synthase 7) (Q9ZQN8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall. Required for synthesis of a cell wall polysaccharide essential for pollen tube growth, for cell wall structure, or for signaling during plant embryo development.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cellulose synthase-like protein D5
- Cellulose synthase-like protein D2
- Cellulose synthase-like protein D1
- Cellulose synthase-like protein D3
- Cellulose synthase-like protein D4
- Cellulose synthase A catalytic subunit 6
- Cellulose synthase A catalytic subunit 1
- Cellulose synthase A catalytic subunit 4
- Cellulose synthase A catalytic subunit 3
- Cellulose synthase A catalytic subunit 8
Sequence:
MSPLPIFHRLPHATFSSFLLSLSQAGSSKTSVAFLNAFKSEDIIARIGLWWQLIRAVVVVPVFKFLVLLCLVMSVMFFVEVMYMGIVVLYVKLFKRKPEKFYKWEAMEDDVECGSASYPMVLVQIPMYNEKEVCEQSIAAACKISWPSNRIIIQVLDDSTDPASKELVKKECDRWSKEGVNITFEIRDNRNGYKAGALREGMRHSYVKQCDYVAIFDADFQPDPDFLHRTVPFLIHNPKLALVQGRWEFVNAGQCMMTRLQEMSLSYHFTIEQQVGSSTFAFFGFNGTAGVWRISALNESGGWNDQTTVEDMDLAVRATLRGWKFLYIDDLKVKSELPCSFKALRSQQHRWTCGPANLLRKMAGQIIRSENVSLWKKWYMLYSFFFMRKIVAHILTFCFYCVILPATVLFPEVTVPKWAAFYLPSLITLLIAIGRLRSIHLLAFWVLFENAMSLLRAKALVMGLFETGRVQEWVVTEKLGDTLKTKLIPQVPNVRFRERVHLLELLVGAYLLFCGIYDIVYGKNTLYVYLLFQSVAFFVVGFGFVGKYVPASSYLA
Protein: Large ribosomal subunit protein uL30m (39S ribosomal protein L30, mitochondrial) (L30mt) (MRP-L30) (Q9D7N6)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q8TCC3}.
Interaction partners:
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein bL17m
- 39S ribosomal protein L40
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein uL22m
- Large ribosomal subunit protein mL41
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL16m
Sequence:
MAGVLRSAFPRPPCRLQTVKKGAESLIGTEWIRHKFTKSRIPDKVFQPKPEDHEKYGGDPQNPHKLHIVTRIRSTKRRPYWEKDTIKMLGLQKAHSPQIHKNIPSVNAKLKVVKHLIRIQPLKLPQGLPTEETMSSTCLKSTGELVVQWHLKPVEQEAKS
Protein: High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (Q8AY96)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Tyrosine-protein kinase
- TYRO protein tyrosine kinase-binding protein
- Hepatic lectin isoform X1
- C-type lectin domain family 4 member E
- IgE receptor gamma.
- Tyrosine-protein kinase
Sequence:
MYGSGIFILLLLNFGAAEAMAEGGLCYILDGVLILYGIVLTILYCRLRMRSGNNEKNEENPDGIYQGLKHKNQDTYETLHVKKEPLA
Protein: Chaperone protein DNAJ, putative (Q57VU5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Heat shock 70 kDa protein, putative
- Heat shock 70 kDa protein, mitochondrial, putative
Sequence:
MSDSGDEYERREDILLQDDINLAGANVNGVDTDPCGYYASLGVSQDSSQAAIRRAFLQLSQIFHTDKHVGEDEEIQALMNERFQQLMEAYSVLSDEGKRAAYDASGKLGLNRYSLIPKEITQREDILRYMSTLEREAELLKLSKLLSASSRTTVSYSVDHLTNSMWKLGTSANDTLQQQSNGVDTEEAGTDEGETETPPKGDIADAANGAEGSSAQPVPLNTSVAVREVQLDGKNLLVLIPGDEVQQQLRQQLQHSTGGGSGGSAAPLSPEQRFGGVPLAAKLLLGLLPRKLHFEHSIHHYASPSFSVRTKTEAQHEGMRSVLRCTAIASYQPNPVTLYSISWRLSVARLHIACTWERILNNLWRLKSKLVLFNTQSLLPMYELSLKRMLAAGLEIENTWVMSMRNRGLFRTTIGQSTPEGAQRGLQFLVGYRSANVSLFSTAPVVWGGGEPGCGGVSRGVLEHSVSVDALRGRAHVGFSSWYTISKYNRIGVGFSTALPCPRGLSRYVSPFVDHPEYLSINEMSFLLGRGDHLIRIPVVVFHSPKVQSALLWLTAPVLLYRIGRLVMRPYQSARMAALYRQNRLDHRTEMDVARVRATHEQKALQSSSLRSRMAEEQIGGLVIINARYGVLQPRYPESLVLPPKQPNAAGNRSEVSGRQRQTWWRFWRAGRGTPTPSESVTVNGKKKDEGEETEGDSSSSVLVLDVTVPLQNFVRDSQLVLPEGSKSKLVGFTDPDPFTRERKQLKIVYRFQRRRHVVILDDEDIVRLPQREHLVES