wanglab/gogpt-training-data huggingface dataset:
Protein: Wiskott-Aldrich syndrome protein family member (WASP family protein member) (F2FB81)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367034}.
Interaction partners:
- Abelson interacting protein, isoform D
- FI14118p
- Cytoplasmic FMR1-interacting protein
- Membrane-associated protein Hem
- Insulin receptor substrate 53 kDa, isoform A
- Wiskott-Aldrich syndrome protein family member
- WASH complex subunit 1
- Actin-related protein 2
- Ras-related protein Rac1
- Cdc42-interacting protein 4, isoform B
Sequence:
MPLPKRSIEPVHVARSVYQQDELQSVELETVTNTTLTNIIRQLSSLSKHAEDVFGELARDVGNIGDRANSLQARIDRLAIKVTQLDSTVEEVPLTDITRKKAFKSAKVFDQQIFSRATMPAPMMDTYAQCDKPPPLDKLNVYRDDGKDGLKFYTDPNYFFELWRQEMLKDTERVMHDKGKKLNRPRQDGGAGGAAGRGNKKQKTKIRVPHNTREQQRQRALVHGETLMPNNVIYRTPNSMVNEEAGYGIQLVKIQTVGEADIDLRHSTLDAHHQVVGNIQDVDTVKPYNMLSHLENNSNVTKQTAVAIADMGVYDTRPPRPNSIELNRSYQSEQIDGSTYEQLPPQMGNQYAATFGNGMGGPQQMHMQHQQMYDAGMYQSHALYGQTGQGVMSPEPIYGPGTPSRNKPRPSQPPPAPPSNGSGGGTPTASNANTPTRGRSMSTSRDALPPPPPVPDVISPMSGMNGVNSGHMAAKLLGRANSSSGAGSPNSVQNANDMVMTQLSNTFHSIGMTGNQLNSLSDLPPPPPVPDQHSPKMSPPNAAPPPPPPPPPVEEGMGSGNQHTLRPHQILPKSLANGEMQQPGQQNGVPHIVAPKKMLPPFHDPRNDLMKAIRDGITLRKVEKSEQKEIERNAAPLDVASILARRVAIELSESEDSDSEDDSEGWMEPNETSA
Protein: Actin-histidine N-methyltransferase (EC 2.1.1.85) (Endothelial differentiation inhibitory protein D10) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (Q91WC0)
Organism: Mus musculus (Mouse)
Function: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86TU7}. Nucleus {ECO:0000269|PubMed:21832073}. Note=Localizes mainly in the cytoplasm. {ECO:0000250|UniProtKB:Q86TU7}.
Interaction partners:
- Histone-lysine N-methyltransferase SETMAR
- Histone-lysine N-methyltransferase NSD3
- Actin, gamma-enteric smooth muscle
- Histone-lysine N-methyltransferase SMYD3
- N-lysine methyltransferase SMYD2
Sequence:
MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPSPGKEWEEYTQIRALVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEEEVRCLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKESFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFQAGDQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHSTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNAEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKIVLKNPDLSVRATMAIKLRLGEKEILEKAVKSAAVNREYYRKHMEERAPLPRYEESDLGLLEGGVGDSRLPLVLRKLEEEAGVQESLSLTETVSKVKAAENGLVNGENLIPNGTRSENESLSPEESENVTGEESSGSMAKVKERL
Protein: Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3) (P18) (P19804)
Organism: Rattus norvegicus (Rat)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P22392}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P22392}. Cell projection, ruffle {ECO:0000250|UniProtKB:P22392}. Nucleus {ECO:0000250|UniProtKB:P22392}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000250|UniProtKB:P22392}.
Interaction partners:
- Nucleoside diphosphate kinase A
- Inosine triphosphate pyrophosphatase
- Nucleoside diphosphate kinase
- dTMP kinase
- Nucleoside diphosphate kinase, mitochondrial
- Guanosine-3',5'-bis
- CTP synthase
- Ribonucleoside-diphosphate reductase
- Nucleoside-triphosphatase, cancer-related
- UMP-CMP kinase
Sequence:
MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFKPEELIDYKSCAHDWVYE
Protein: At5g27920 (F-box family protein) (Q8GZ31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F-box/kelch-repeat protein At1g67480
- MJK13.9 protein family protein)
- Probable apyrase 7
- F-box/kelch-repeat protein At5g60570
- AT5g02480/T22P11_70
- F-box protein At1g30200
- GPN-loop GTPase 3
- TOM1-like protein 5
- Probable methyltransferase PMT24
- AT3G11930 protein
Sequence:
MSTSPSILSVLSEDLLVRVYECLDPPCRKTWRLISKDFLRVDSLTRTTIRILRVEFLPTLLFKYPNLSSLDLSVCPKLDDDVVLRLALDGAISTLGIKSLNLSRSTAVRARGLETLARMCHALERVDVSHCWGFGDREAAALSSATGLRELKMDKCLSLSDVGLARIVVGCSNLNKISLKWCMEISDLGIDLLCKICKGLKSLDVSYLKITNDSIRSIALLVKLEVLDMVSCPLIDDGGLQFLENGSPSLQEVDVTRCDRVSLSGLISIVRGHPDIQLLKASHCVSEVSGSFLKYIKGLKHLKTIWIDGAHVSDSSLVSLSSSCRSLMEIGLSRCVDVTDIGMISLARNCLNLKTLNLACCGFVTDVAISAVAQSCRNLGTLKLESCHLITEKGLQSLGCYSMLVQELDLTDCYGVNDRGLEYISKCSNLQRLKLGLCTNISDKGIFHIGSKCSKLLELDLYRCAGFGDDGLAALSRGCKSLNRLILSYCCELTDTGVEQIRQLELLSHLELRGLKNITGVGLAAIASGCKKLGYLDVKLCENIDDSGFWALAYFSKNLRQINLCNCSVSDTALCMLMSNLSRVQDVDLVHLSRVTVEGFEFALRACCNRLKKLKLLAPLRFLLSSELLETLHARGCRIRWD
Protein: Sugar transporter ERD6-like 4 (Q93YP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sugar transporter.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Vacuolar ATPase assembly integral membrane protein VMA21 homolog
- At1g20770
Sequence:
MSFRDDNTEEGRNDLRRPFLHTGSWYRMGSRQSSMLESSQVIRDSSISVLACVLIVALGPIQFGFTCGYSSPTQAAITKDLGLTVSEYSVFGSLSNVGAMVGAIASGQIAEYVGRKGSLMIAAIPNIIGWLSISFAKDTSFLYMGRLLEGFGVGIISYTVPVYIAEIAPQTMRGALGSVNQLSVTIGIMLAYLLGLFVPWRILAVLGVLPCTLLIPGLFFIPESPRWLAKMGLTDDFETSLQVLRGFETDITVEVNEIKRSVASSSKRSAVRFVDLKRRRYYFPLMVGIGLLALQQLGGINGVLFYSSTIFESAGVTSSNVATFGVGVVQVVATGIATWLVDKAGRRLLLMISSIGMTISLVIVAVAFYLKEFVSPDSNMYNILSMVSVVGVVAMVISCSLGMGPIPWLIMSEILPVNIKGLAGSIATLLNWFVSWLVTMTANMLLAWSSGGTFTLYALVCGFTVVFVSLWVPETKGKTLEEIQALFR
Protein: ATP synthase subunit a (F-ATPase protein 6) (P00850)
Organism: Drosophila melanogaster (Fruit fly)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein.
Interaction partners:
- ATP synthase subunit alpha, mitochondrial
- NADH-ubiquinone oxidoreductase chain 5
- NADH-ubiquinone oxidoreductase chain 2
- ATPase protein 9
- NADH-ubiquinone oxidoreductase chain 1
- Cytochrome c oxidase subunit 2
- ATP synthase subunit gamma, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4
- Cytochrome c oxidase subunit 3
- Cytochrome b
Sequence:
MMTNLFSVFDPSAIFNFSLNWLSTFLGLLMIPSIYWLMPSRYNIMWNSILLTLHKEFKTLLGPSGHNGSTFIFISLFSLILFNNFMGLFPYIFTSTSHLTLTLSLALPLWLCFMLYGWINHTQHMFAHLVPQGTPAILMPFMVCIETISNIIRPGTLAVRLTANMIAGHLLLTLLGNTGPSMSYILVTFLLMAQIALLVLESAVAMIQSYVFAVLSTLYSSEVN
Protein: AdoMet-dependent rRNA methyltransferase spb1 (EC 2.1.1.-) (2'-O-ribose RNA methyltransferase) (S-adenosyl-L-methionine-dependent methyltransferase) (O42832)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.
Subcellular location: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03163}.
Interaction partners:
- Probable rRNA-processing protein ebp2
- 25S rRNA
- Ribosome biogenesis protein erb1
- Pescadillo homolog
- Ribosome biogenesis protein rlp24
- Uncharacterized RNA-binding protein C1827.05c
- GTPase grn1
- Uncharacterized NOC2 family protein C1142.04
- Protein mak16
- Nucleolar complex-associated protein 3
Sequence:
MGKSQKKTAKGRLDKWYKLAKEQGYRSRAAFKLVQLNQKYSFLEKAKVIIDLCAAPGGWLQVASKTCKPGSLIVGVDLAPIKPIPNCHTFVEDITSDKCRSQLRGYLKTWKADVVLHDGAPNVGSAWLQDAYGQAQLVLMSMKLACEFLVAGGTFVTKVFRSRDYNNLLWVFKQLFNKVEATKPPSSRNVSAEIFVVCRGYKAPKKLDPRFTDPRTVFEEVQEPVTNVDAKVFHPEKRKRSREGYADDDYTLHKTVLASEFVTANDPIQILGTSAEIVFPKDDEECQRLYNLDVTTEEILLCCSDLQVLGKKEFRDILRWRLKIRDEMGIGKKVEDEQKTVVEEIPEMDEEERLDQELQDLSEAERVKLKRERRKANQRKQREIVRMQMGMLAPMDIGLEHEAMGEDSLFGLATAEKHGLKELENGTLPVTESVDEEVSTDNEVEYDSDDERDRLEADLDSMYSDYTKRKAESDVKYRVKKARGDLDDEEWNGIDNGTESDDSQIAETNFATPDKDRLTTSLLDKGSTKDGLSRKARMFFDQDIFDGIEDADADVEIMSMNRAAIKKREAELASQNNDDGSKGDQSEDSNDHIEVVPVASAHDEDDDWNSDSDNDENNVEIVTAEAMTLAQDIASRRKSKADLIDEGYNRWSFQSKEGLPDWFLDEETTVNKPNKPITKEAVLALREKMKALNARPIKKVLEAQGRKKMRTIKRLQRVAKKAEGISESGDMTESEKAKEISRLVSRATKSKPKAKPTLVVAKGPNKGLKSRPKGVKGKYKMVDSRMKKDLRAQKRLAKKGRR
Protein: Interleukin family protein (Q6H8Q2)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU368043}.
Interaction partners:
Sequence:
MPSSSAVLCCLVFLAGVAASRDASTLSDSSCTHFPASLPHMLRELRAAFGKVKTFFQMKDQLNSMLLTQSLLDDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEQVKRVFNMLQERGVYKAMSEFDIFINYIESYMTTKM
Protein: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT) (Q12555)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03106}.
Interaction partners:
- Adenylyl-sulfate kinase
- Phosphoadenosine phosphosulfate reductase
- Bis
- Sulfite reductase subunit beta
- 3'
- 3'
- Sulfite oxidase, putative
- assimilatory sulfite reductase
- Molybdopterin binding domain protein
- FAD synthase
Sequence:
MANTPHGGVLKDLIARDAPRHDQLEAEAATLPSIVLTERQLCDLELIMNGGFSPLEGFMNQKDYDGVVAESRLADGNLFSMPITLDASKAVIEQAGLKPGSRVTLRDFRDDRNLAILTIDDIYRPDKEKEAKLVFGGDPEHPAIKYLNTKVEEYYIGGKLEAVNKLNHYDYVGLRYTPAELRIHFDKLGWTRVVAFQTRNPMHRAHRELTVRAARARQANVLIHPVVGLTKPGDIDHFTRVRAYQALLPRYPNGMAALALLPLAMRMGGPREAVWHAIIRKNHGATHFIVGRDHAGPGKNSKGQEFYGPYDAQHAVEKYRAELGIEVVEFQQVTYLPDTDEYMPKDEVPAGTKTLDISGTELRNRLRTGAHIPEWFSYPEVVKILRESSPPRALQGFTIFLTGYMNSGKDAIARALQVTLNQQGGRSVTLLLGDTVRHELSSELGFSREDRHTNVQRIAFVAGELTRAGAAVIAAPIAPYEHSRKAAREAVQSTGGSFFLVHVNTPLEYCEATDKRGIYAKARRGEIKGFTGVDDPYEAPTNANLVVDVSKQSVRSIVHEIILMLESEGYFERL
Protein: Sodium/potassium-transporting ATPase subunit beta-1 (Protein nervana 1) (Sodium/potassium-dependent ATPase subunit beta-1) (Q24046)
Organism: Drosophila melanogaster (Fruit fly)
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit alpha
- Sodium/potassium-transporting ATPase subunit beta-2
- Multidrug resistance protein homolog 65
- Sodium/potassium-transporting ATPase subunit alpha
- Uncharacterized protein, isoform A
- Uncharacterized protein, isoform A
- ABC-type xenobiotic transporter
- Multidrug resistance protein homolog 49
Sequence:
MSKNNGKGAKGEFEFPQPAKKQTFSEMIYNPQEGTFFGRTGKSWSQLLLFYTIFYIVLAALFTICMQGLLSTISDTEPKWKLQDSLIGTNPGLGFRPLSEQTERGSVIAFDGKKPAESDYWIELIDDFLRDYNHTEGRDMKHCGFGQVLEPTDVCVVNTDLFGGCSKANNYGYKTNQPCIFLKLNKIFGWIPEVYDKEEKDMPDDLKKVINETKTEERQQVWVSCNGHLGKDKENFQNIRYFPSQGFPSYYYPFLNQPGYLSPLVAVQFNSPPKGQMLDVECRAWAKNIQYSGSVRDRKGSVTFQILLD
Protein: Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL) (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Q7TMW6)
Organism: Mus musculus (Mouse)
Function: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity).
Interaction partners:
- MMS19 nucleotide excision repair protein homolog
- Probable cytosolic iron-sulfur protein assembly protein CIAO1
- Cytosolic iron-sulfur assembly component 2B
- Cytosolic iron-sulfur assembly component 2A
- Cytosolic Fe-S cluster assembly factor NUBP1
- Cysteine desulfurase
- Ferredoxin-2, mitochondrial
- Iron-sulfur cluster assembly enzyme ISCU
- LYR motif-containing protein 4
- Anamorsin
Sequence:
MASPFSGALQLTDLDDFIGPSQNCIKPVKVAKKPGSGIAKIHIEDDGSYFQVNQDGRTQKLEKAKVSLNDCLACSGCVTSAETVLITQQSHEELRKVLDANKEAAPGQQRLVVVSISPQSRASLAARFRLDPTDTARKLTSFFKKIGVHFVFDTAFARNFSLLESQKEFVQRFREQANSREALPVLASACPGWICYAEKTHGNFILPYISTARSPQQVMGSLVKDFFAQQQLLTPDKIYHVTVMPCYDKKLEASRPDFFNQEYQTRDVDCVLTTGEVFRLLEEEGVSLTELEPAPLDGLTSSVSAEEPSSHRGGGSGGYLEHVFRHAAQELFGIHVAEVTYQPLRNKDFQEVTLEREGQVLLRFAVAYGFRNIQNLVQKLKRGRCPYHYVEVMACPSGCLNGGGQLKAPDTEGSELLQQLERLYSMVRTEAPEDAPGVQELYQHWLQGEDSERASRLLHTQYHAVEKPSSGLSIRW
Protein: Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (PreS1-binding protein) (Q8BK35)
Organism: Mus musculus (Mouse)
Function: Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription (By similarity). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation. It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex. May also regulate cellular aerobic respiration. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:21804542}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9NZM5}. Note=In the nucleolus may be more specifically localized to the fibrillar center. Mainly nucleolar it relocalizes to the nucleoplasm under specific conditions including ribosomal stress enabling it to interact and regulate nucleoplasmic proteins like p53/TP53. Also detected in the cytosol. {ECO:0000250|UniProtKB:Q9NZM5}.
Interaction partners:
- GTP-binding protein 4
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- Ribosomal L1 domain-containing protein 1
- Nucleolar GTP-binding protein 2
- Protein SDA1 homolog
- Notchless protein homolog 1
- Exosome RNA helicase MTR4
- Large ribosomal subunit protein uL18
- Pescadillo homolog
- Ribosome production factor 2 homolog
Sequence:
MAAGGNRDGEKRGSRSQADSGFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAEEPLGLEVDQFLEDVRLQERTTGGLLAEAPNEKLFFVDTGFKRKEPRKKRTLVQKKSQRLQKPLRVDLALENHSKIPAPKDILAHQVPNAKKLRRKEELWEKLAKQGELPRDVRKAQARLLSPPTPKAKPGPQDIIERPFYDLWNPDNPLDTPLIGQDAFFLEQTKKKGVRRPQRLHIKPSQVPAVEVIPAGASYNPTFEDHQALLREAHEVELQREKEAEKLERQLALPTSEQAATQESVFREMCEGLLEESDGEDEHEAGRAGQPEAGDGTTEISPTGAAGPEKRMEKKTEQQRRREKAARKLRVQQAALRAARLQHQELFRLRGIKAQVARRLAELARRREQRRIRRLAEADKPRRLGRLKYQAPDIDVQLSSELSGSLRTLKPEGHILRDRFKSFQKRNMIEPRERAKFKRKYKVKLVEKRAYREIQL
Protein: Cell division protein FtsZ (P0A9A6)
Organism: Escherichia coli (strain K12)
Function: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. Polymerization and bundle formation is enhanced by CbeA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00909, ECO:0000269|PubMed:1944597, ECO:0000269|PubMed:8917533}. Note=Assembles in a ring-like structure at midcell at the inner surface of the cytoplasmic membrane. {ECO:0000269|PubMed:14731269, ECO:0000269|PubMed:1944597, ECO:0000269|PubMed:30343895, ECO:0000269|PubMed:8917533}.
Interaction partners:
- Cell division protein ZipA
- Cell division protein FtsA
- Cell shape-determining protein MreB
- Cell division protein ZapA
- Cell division ATP-binding protein FtsE
- Septum site-determining protein MinC
- Cell division protein FtsQ
- Peptidoglycan D,D-transpeptidase FtsI
- Probable peptidoglycan glycosyltransferase FtsW
- Cell division protein ZapC
Sequence:
MFEPMELTNDAVIKVIGVGGGGGNAVEHMVRERIEGVEFFAVNTDAQALRKTAVGQTIQIGSGITKGLGAGANPEVGRNAADEDRDALRAALEGADMVFIAAGMGGGTGTGAAPVVAEVAKDLGILTVAVVTKPFNFEGKKRMAFAEQGITELSKHVDSLITIPNDKLLKVLGRGISLLDAFGAANDVLKGAVQGIAELITRPGLMNVDFADVRTVMSEMGYAMMGSGVASGEDRAEEAAEMAISSPLLEDIDLSGARGVLVNITAGFDLRLDEFETVGNTIRAFASDNATVVIGTSLDPDMNDELRVTVVATGIGMDKRPEITLVTNKQVQQPVMDRYQQHGMAPLTQEQKPVAKVVNDNAPQTAKEPDYLDIPAFLRKQAD
Protein: Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) (Q9P2R6)
Organism: Homo sapiens (Human)
Function: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10814707, ECO:0000269|PubMed:11331249}. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
Interaction partners:
- Histone deacetylase 1
- Histone deacetylase 2
- COUP transcription factor 2
- Histone acetyltransferase p300
- WD repeat-containing protein 5
- Histone-lysine N-methyltransferase EHMT2
- Retinoic acid receptor beta
Sequence:
MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL
Protein: Putative nucleotidyltransferase MAB21L1 (EC 2.7.7.-) (Protein mab-21-like 1) (Q13394)
Organism: Homo sapiens (Human)
Function: Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye. It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O70299}.
Interaction partners:
- Neurobeachin
- Homeobox protein Meis2
- Homeobox protein Meis1
- Pre-B-cell leukemia transcription factor 1
- LIM homeobox transcription factor 1-beta
- Pre-B-cell leukemia transcription factor 3
- Pre-B-cell leukemia transcription factor 2
- Protein FAM222A
- Serine/threonine-protein kinase DCLK1
Sequence:
MIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHSLAGKQSSAESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL
Protein: Growth and differentiation factor 9 (Growth/differentiation factor 9) (Q5MD90)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MATLFFKCSALCYLPRSLIVLAVLGLSITSSYNFENESVEPDVPLQHGNILSPLLKALSEQNPWGEFTHRTKPDSRYVRYMRRLYKQSSKPYRSPEASHLYNTARLITPREECLKQNREFFMQDISYSLNRVRSQEHLLKSVLLYSFDHNHLSPFSLLCYLDMKEQKSSKDQMCSNHLGIQHSVPLLSFRVHHRWVEVDVTSFLHPLIQAHKKDIHLLINLTCVEDMISRPGGQIHKSPVELTPRSPSLLLYLNDTSEVAYQRRSTQGRMVDLTSNHWDGKSTLWELTSRRRRGTLKSSETSMPKLVPMYEFTTDDCDLYDFRVSFKELKLDHWIIEPKKYNPRYCKGSCPRNVGFMYGSPMHTMVQNLIYEKLDSSVPRPTCVPSEYNPLSVLTFENDKSYAYKEYEEMIATKCACR
Protein: Calbindin (H0ZNK9)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Interaction partners:
Sequence:
MTAETHLQGVEISAAQFFEIWHHYDSDGNGFMDGKELQNFIQELQQARKKAGLDLTPEMKAFVDQYGKSTDGKIGIVELAQVLPTEENFLLFFRCQQLKSSEDFMQTWRKYDSDHSGFIDSEELKSFLKDLLQKANKQIEDSKLTEYTEIMLRMFDANNDGKLELTELARLLPVQENFLIKFQGVKMCAKEFNNAFEMYDQDGNGYIDENELDALLKDLCEKNKKTLPTLQHTRKASWPCLMEESFTEQNWLLFSVLRKTRALLSCPLN