wanglab/gogpt-training-data huggingface dataset:
Protein: GM01918p (Q95SE0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAEFSVERVEDKRTVNGRTEYYLKWKGYPRSENTWEPVENLDCPDLIANFEESLKNNKKETKKRLSTSSTPESIRSKRKSFLEDDTEEQKKLIGFERGLEASKILGATDSSGHLMFLMKWKGSDHADLVPAKLANTRCPQVVIQFYEERLTWHTGSGNGNGNTNSVNLGSSGGLGSVGGSGAGDDTAPGSVGTTGGGSNIDGGDEEDPEPVSPIGSINQDENIKPDESSELDNGQPDADD
Protein: DNA-(Apurinic or apyrimidinic site) endonuclease (Q564V5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSKRKAEEAPAPKLASIFTKKVKPAEEDNNQKSWKFVCWNVAGLRACVKKSDFKEVLAEEPDLVFLGETKCKEWPPEMEETFKNYTKTLVVSTEKNGGYAGVGLLSKCAPMKVHKGIGDPEFDTAGRLIIAEFSKFYFIGAYVPNSGAKLVNLEKRGRWEKLLTEKMKEMDEKKPVIYGESRIKSK
Protein: Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) (Q04760)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis (By similarity).
Interaction partners:
- Hydroxyacylglutathione hydrolase, mitochondrial
- Glyoxylate reductase/hydroxypyruvate reductase
- S-formylglutathione hydrolase
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- Phosphoacetylglucosamine mutase
- Amine oxidase [flavin-containing] A
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- Amine oxidase [flavin-containing] B
- Serine dehydratase-like
- L-serine dehydratase/L-threonine deaminase
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
Protein: Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) (Q6DBW0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9H5V7}.
Interaction partners:
Sequence:
MGEEKPEPLDFVKDFQEYLSQQTQHVNMISGSVIGVKDSDDLQGELAQNGLEHPAVDMSLEDSSGMLVDGFERTYDGKLKCRYCNYATRGTARLIEHIRIHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRRHKLLPMKGARSALSHRKMLSVLQKRGNSLGYGRRLLINLSPPSMVLQKPSSEQHHLGDFTHDLPPHAHLHQEAYNGLGKDPQAIGGAIGSGSREDQDMALDNPLNQLSTLAGQLASIPSEAEGAPVSPGAESLPDEKPTFLVQQPVTAPAAVSVNTAQASSPITPEPRPAAHSGCSPGVGPCSERTSTPSGTNSQPGTPTPVQDPQMLHHCPHCHIYFPDNILYTIHMGCHGYENPFQCNICGHRCRNSYDFACHFARGQHK
Protein: HMG box-containing protein C10F6.08c (O42648)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Chromatin-remodeling ATPase INO80
- Probable actin-related protein 8
- INO80 complex subunit 1
- Chromatin-remodeling complex subunit ies6
- RuvB-like helicase 2
- Actin-like protein arp5
- RuvB-like helicase 1
- SWI/SNF and RSC complexes subunit arp42
- Uncharacterized protein C16C4.20c
- INO80 complex subunit 3
Sequence:
MENPPYHVSISKSEEIKYRQKCKDLKARIQEIQKGNQELLSKYEVIRRAVKRGRLERAILMEQLELQSEAKSREFGQRSEPSPPPPPEGIKIKISTKGAGNPSAKKLKISTEETSDTNVALNNTSEISHKSSNNSQPKDASVNDTDADFEQQNQVVQSKDEKITNTDPIPSPIITNLKTESSKSSGAKKATSNAKITDTMLFNHFSSIQKPKLKAEGSTLKGQALKKTLEDTWNNLTEEEKKPYHEGLLAAREKAREARRRRSAQNSAKLEKEKAKEKQKDKDQEQDTVSDKNQIDEIEKGQKEVDEEPVSEPTTSPILPPKNQEPIRMGGFTVVNRSSNA
Protein: Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1) (Q8TDR2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus. Nucleus, nucleolus. Cytoplasm. Note=When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers (PubMed:11973348). However, PubMed:19756140 detected STK35 only in the nucleus, and the presence of PDLIM1 had no influence on its location. {ECO:0000269|PubMed:11973348}.
Interaction partners:
- PDZ and LIM domain protein 1
- Ubiquitin-like-conjugating enzyme ATG3
- Phosphoinositide 3-kinase regulatory subunit 4
- Autophagy protein 5
- Ubiquitin-like protein ATG12
- Phosphatidylinositol 3-kinase catalytic subunit type 3
Sequence:
MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAAEGSATRRARAATSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKDGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA
Protein: Small nuclear protein PRAC1 (Prostate cancer susceptibility candidate protein 1) (Prostate, rectum and colon expressed gene protein) (Q96KF2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:11340635}.
Interaction partners:
- Protein PRAC2
- Homeobox protein Hox-B13
Sequence:
MLCAHFSDQGPAHLTTSKSAFLSNKKTSTLKHLLGETRSDGSACNSGISGGRGRKIP
Protein: Serum amyloid A-1 protein (P05366)
Organism: Mus musculus (Mouse)
Function: Major acute phase protein.
Subcellular location: Secreted {ECO:0000269|PubMed:9518179}.
Interaction partners:
- Serum amyloid A-2 protein
- Serum amyloid A-3 protein
- Haptoglobin
Sequence:
MKLLTSLVFCSLLLGVCHGGFFSFVHEAFQGAGDMWRAYTDMKEANWKNSDKYFHARGNYDAAQRGPGGVWAAEKISDGREAFQEFFGRGHEDTIADQEANRHGRSGKDPNYYRPPGLPDKY
Protein: Coiled-coil-helix-coiled-coil-helix domain containing 3 (Q9D9P1)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00034476}; Lipid-anchor {ECO:0000256|ARBA:ARBA00034476}.
Interaction partners:
Sequence:
MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSSVYGASVSDEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLARQLEEKDRVMRKQDAFYKEQLARLEERSSEFYKVTTEEYQKAAEEVEAKFK
Protein: Ral GTPase-activating protein subunit beta (p170) (Q8BQZ4)
Organism: Mus musculus (Mouse)
Function: Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.
Interaction partners:
- Ral GTPase-activating protein subunit alpha-2
- Ras-related protein Ral-A
- RAC-beta serine/threonine-protein kinase
- Transmembrane protein 131
Sequence:
MYSEWRSLHLVIQSDQGHTSVLHSYPESVGREVANAVVRPLGQALGTSSVAGSESLLKTDKEVKWTMEVICYGLTLPLDGETVKYCVDVYTDWIMALVLPKDSIPLPIIKEPNLYVQSILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSIMARETWEVLLLFLLQINDILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPPFKVPDEDANLIPPEMDNECIAQTWFRFLHMLSNPVDLSNPAVISSTPKFQEQFLNVSGMPQELSQYPCLKHLPQIFFRAMRGISCLVDAFLGISRPRSDSAPPTPVNRLSMPQSAAVNTTPPHNRRHRAVTVNKATMKTSTVTTAHTSKVQHQASSTSPLSSPNQTSSEPRPLPAPRRPKVNSILNLFGSWLFDAAFVHCKLHNGINRDNSMTASFIQILLSYKSSIATQASMEFRRKGSQMSTDTMVSNPVFDASEFPDNYEAGRAEACGTLCRIFCSKKTGEEILPAYLSSVILNSPPLFCCDLKGIDVVVPYFISALETILPDRELSKFKSYVNPTELRRSSINILLSLLPLPHHFGTVRSEVVLEGKFSNDDSSSYDKPITFLSLKLRLVNILIGALQTETDPNNTQMILGAMLNIVQDSALLEAIGCQMEMGGGENNLKSHSRTNSGISSASGGSTEPTTPDSERPAQALLRDYGSTDSAAGLLIRSIHLVTQRLNSQWRQDMSISLAALELLSGLAKVKVMVDSGDRKRAISSVCSYIVYQCSRPAPLHSRDLHSMIVAAFQCLCVWLTEHPDMLDEKDCLKEVLEIVELGISGSKSKNSEQEVKYKGDKEPNPASMRVKDAAEATLTCIMQLLGAFPSPSGPASPCSLVNETTLIKYSRLPTINKHSFRYFVLDNSVILAMLEQPLGNEQNDFFPSVTVLVRGMSGRLAWAQQLCLLPRGAKANQKLFVPEPRPVPKNDVGFKYSVKHRPFPEEVDKIPFVKADLSIPDLHEIVTEELEERHEKLRSGMAQQIAYEMHLEQQSEGELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVFIFYMKPGQKTNQEILKNVESSRNVQPHFLEFLLSLGWSVDVGKHPGWTGHVSTSWSINSCDDGEGSEPDEITSSEDVGASIFNGQKKVLYYADALTEIAFVVPSPVESLTDSLESNISDQDSDSNMDLMPGILKQPPLTLELVPNHTDSLNSSQRLSPSSRMKKLPQGRPVPPLGPETRVSVVWVERYDDIENFPLSDLMTEISTGVETTANSSTSLRSTTLEKEVPVIFIHPLNTGLFRIKIQGATGKFNMVIPLVDGMIVSRRALGFLVRQTVINICRRKRLESDSYSPPHVRRKQKITDIVNKYRNKQLEPEFYTALFQEVGLKNCSS
Protein: Branched-chain amino acid aminotransferase, putative (Q586R1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 3-methyl-2-oxobutanoate dehydrogenase
- 2-oxoisovalerate dehydrogenase subunit alpha
- Homoserine kinase, putative
- Branched-chain amino acid aminotransferase, putative
- Glutamate--cysteine ligase
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- hydroxymethylglutaryl-CoA lyase
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Phosphonopyruvate decarboxylase-like protein, putative
Sequence:
MTFLAKKIFVQRVANPPPLPSLQGVMFGTLFSPHMLVIDADGNGKWGKPRIVPFENLSLPPQTACLHYAIQCFEGMKAYRDSHGNIRLFRPDRNCRRLLDSTRRLCLPGFDPDELQKLIEEFVKVERDYVPSERGYSLYLRPTVIGTGSKLSAVAGSAAKLFVIASPVGPYYPSGMKPVRLHVEEERRRAWPGGVGNVKLGANYAAPMLVQQEASELGFQQVLWLGAGEEVQEVGAMNFMCLWRPSANSNEVELVTAPLDGTILPGVTRDSILSLVRQWGEARVSERSFTIHELTAALREKRVLECFGCGTAAIVSPVEALSYKGELLNVPCPAPGASLTHRVLKAITDIQYGDVEHEWSRIVGTTS
Protein: Iron-sulfur cluster-binding protein (Q72FP1)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Thiosulfate reductase, putative
- Formate dehydrogenase, alpha subunit, selenocysteine-containing
- Menaquinone reductase, molybdopterin-binding-like subunit
- Formate dehydrogenase, alpha subunit, selenocysteine-containing
- Formate dehydrogenase 2 subunit alpha
- Molybdopterin oxidoreductase domain protein
- Uncharacterized protein
- Reductase, transmembrane subunit, putative
- Menaquinone reductase, integral membrane subunit
- Iron-sulfur cluster-binding protein
Sequence:
MSRYCIVTDQDRCISCKACEVHCKVANNVPVGARLGMHIASGPHDVDGRPDIRTMFMPCFQCDEPWCVPVCPTGAIAKRESDGIVAIDADTCVGCKACITACPWRVPQWNPVTEKAVKCDLCRDRLDAGLRPACVTACTTHALELVSAEVGASLPCTGIDAVRKVAARPVPASMPPAPKGQRQPRLGDVEKAIAAGEVQTLVVLCQALDDALPTPYEAGCIPQGMALSDARLRPDLGDVPLPPQTMLRKVRCARRFAAKSLPKFLAAGLKALLVFACPPTMCASHEDGKIPATGLADLARACADAGVRLVVHEACPAGPDAVRDAVAAFSRQA
Protein: BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) (Q9NZM4)
Organism: Homo sapiens (Human)
Function: Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May play a role in BRD4-mediated gene transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:21555454}.
Interaction partners:
- Bromodomain-containing protein 9
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Protein SSXT
- B-cell CLL/lymphoma 7 protein family member A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
- B-cell CLL/lymphoma 7 protein family member C
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- SWI/SNF complex subunit SMARCC1
- AT-rich interactive domain-containing protein 1A
Sequence:
MDDEDGRCLLDVICDPQALNDFLHGSEKLDSDDLLDNPGEAQSAFYEGPGLHVQEASGNHLNPEPNQPAPSVDLDFLEDDILGSPATGGGGGGSGGADQPCDILQQSLQEANITEQTLEAEAELDLGPFQLPTLQPADGGAGPTGAGGAAAVAAGPQALFPGSTDLLGLQGPPTVLTHQALVPPQDVVNKALSVQPFLQPVGLGNVTLQPIPGLQGLPNGSPGGATAATLGLAPIQVVGQPVMALNTPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKNLSAAVATTLNGNSVFGGAGAASAPTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAGVLPPKLYQLTPKPFAPAGATLTIQGEPGALPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQANVFKQPPATTTGAAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAVQLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGPLSLGPVLAPHSGAHSAHILSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMAATGLPPLLPAENKAFASNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSKEACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGALPSPSDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEEKTTLALDKQLAKEKPDEYVSSSRSLGLPIAASSEGHRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSVTWARASSSLSSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAPHCPRLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVEDELYQRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGTPASPPPLHRPEAYPPSSHNGGLGARTLTR
Protein: Protein Syd (P0A8U0)
Organism: Escherichia coli (strain K12)
Function: Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
Subcellular location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Interaction partners:
- Der GTPase-activating protein YihI
- UPF0208 membrane protein YfbV
- Phosphohistidine phosphatase SixA
- RNA chaperone ProQ
- Regulator of ribonuclease activity B
- Negative modulator of initiation of replication
- Uncharacterized protein YjaG
- Cell division protein ZapC
- Uncharacterized protein YheV
- Uncharacterized protein YigA
Sequence:
MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL
Protein: Synaptopodin (Q8CC35)
Organism: Mus musculus (Mouse)
Function: Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9314539}. Cell junction, tight junction {ECO:0000269|PubMed:9314539}. Perikaryon {ECO:0000269|PubMed:9314539}. Cell projection, dendritic spine {ECO:0000269|PubMed:12928494, ECO:0000269|PubMed:9314539}. Postsynaptic density {ECO:0000269|PubMed:9314539}. Synapse {ECO:0000269|PubMed:9314539}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8N3V7}. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses (PubMed:9314539). {ECO:0000269|PubMed:9314539}.
Interaction partners:
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
- CD2-associated protein
- Actin, cytoplasmic 1
- Alpha-actinin-4
- Nephrin
- Podocin
- Actin, cytoplasmic 2
- Podocalyxin
- Dendrin
- Wilms tumor protein homolog
Sequence:
MLGAHFPPPPLGASEGRAAPCTFQIPDGSYRCLALEAEESSSEDGLQGEVRLVDLEEEGTSQSRANHGTPPLSRAPAIIQPSSCHREARGGFQRSDRPSHDWDVVQARKVMTASGSSSPVPRVAQKPALGRSTSFTENDLKEAKARSQQIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESRGQRSPKLNQEALQTGRPLSPIGHAPGPSVKPTSPSKPGSPKHPSPQSPSRGVAGHIMEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQSRETQQSSPNPPDTEVPSPAADINQNPSSPNATLTTLASSSHHSQPTADINQNPPAAITPVPQNSSQAQCSPNGTLDSKPGTLCADDGQSPVPAEEVRSSILLIDKVSAPPSAASTFSREATPLSSSGPPAADLMSSSLLIDMQPSTLVAPAEQEVPGHVAVTTPTKVYSEVHLTLAKPASVVNRTARPFGIQSPGTSQIEQSPMMGRRQFGEKAWAPPASSMADRSPQPQRHIMSRSPMVERRLLGQRSPVLERRPLGNFTPPPTYAETLSTAPVASRVRSPPSYSTLYPSSDPKPSHLKGQVAPANKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDHGEVGMEEEPFALGAEASNFQQEPIARDRASPAAAEEAVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSGHAELARCPSPTMSLPSSWKYTTNAPGGFRVASLSPARTPPASLYHGYLPENGVLRPEPTKQQPYQMRPSLYALSPVKEPAKASSRATSSRTPSRTVSPRAASPAKPSSLDLVPNLPRAGLPPSPALPRPSRSSPGLYTAPVQDSLQPTAVSPTYSSDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPSFCFK
Protein: Protein POLLEN DEFECTIVE IN GUIDANCE 1 (F4HVJ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable component of the calreticulin 3 (CRT3) complex, acting probably as a co-chaperone involved in protein retention in the endoplasmic reticulum lumen. Required for micropylar pollen tube guidance. Plays an essential role in cell plate orientation or positioning in early embryo patterning.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:21954464}. Note=Exclusive ER lumen localization and no membrane localization in PubMed:21954464.
Interaction partners:
- Protein NUCLEAR FUSION DEFECTIVE 4
Sequence:
MAIRSSGRKLSFEILSQNSSFENDDTSIRRSSSDPITGNVASESPRDYGKRKRSKKKKKKVNQVETILENGDSHSTIITGSSGDFGETTTMFENRLNYYGGGGSGSSGGGCVVTLLDGQTVHHNGFNFGELRQRNVNGSVDGSNDERWSDTLSSDKKLYMEETSVELSPSENPPFQEVQHQFPRSEINGNVVRRLDTEASLDWKQLVADDPDFLSAETRSPMKYFMEEIYGGISLRSTTTPGNDIERERIYDTIFRLPWRCEVLIDTGFFVCVNSFLSLLTVMPIRVLLIFMDAFKNRQFRRPSASELSDLACFLVLATGTILLGRTDISLIYHMIRGQSTIKLYVVYNILEIFDRLCQSFCGDVFGALFSSAKGLSISPPEKLRFSTWRFVSDLALTMAASILHSFILLAQAITLSTCIVAHNNALLALLVSNNFAEIKSSVFKRFSKDNIHGLVYADSIERFHISAFLVSVLAQNILESEGAWFGNFIYNATTVFFCEMMIDIIKHSFLAKFNDIKPIAYSEFLQALCEQTLNIRPEDRKTNLTFVPLAPACVVIRVLTPVYAAHLPYSPLPWRMLWMVILFVITYIMLTSLKVLIGMGLRKHATWYINRCRRRNSSHLHND
Protein: Mucin-1 (A0A0A0MRB3)
Organism: Homo sapiens (Human)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004247}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004247}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTPGTQSPFFLLLLLTVLTATTAPKPATVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAFLQIYKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVSVSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPARDTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAATSANL
Protein: Omega-3 fatty acid desaturase fat-1 (FAT-1) (EC 1.14.19.-) (FAT-1 N3 desaturase) (Fatty acid desaturase 1) (Fatty acid metabolism 1) (Q9NEQ0)
Organism: Caenorhabditis elegans
Function: Omega-3 fatty acid desaturase that recognizes a range of 18- and 20-carbon omega-6 substrates. Introduces a double bond in the fatty acid chain three carbons away from terminal methyl group to biosynthesize n-3 (omega-3) polyunsaturated fatty acids (PUFAs) endogenously (PUFAs are essential for membrane structure and many cellular and physiological processes). Acts on a number of substrates like linoleoyl-CoA ((9Z,12Z)-octadecadienoyl-CoA, 18:2n-6), dihomo-gamma-linolenoyl-CoA ((8Z,11Z,14Z)-eicosatrienoyl-CoA, 20:3n-6), and arachidonoyl-CoA ((5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA, 20:4n-6), to generate alpha-linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA, 18:3n-3), (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA (20:4n-3) and (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA (20:5n-3) respectively. Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Delta
- Delta
- Delta
- Delta
- Delta
- Long chain fatty acid elongase 1
- Long chain fatty acid elongase 2
Sequence:
MVAHSSEGLSATAPVTGGDVLVDARASLEEKEAPRDVNANTKQATTEEPRIQLPTVDAFRRAIPAHCFERDLVKSIRYLVQDFAALTILYFALPAFEYFGLFGYLVWNIFMGVFGFALFVVGHDCLHGSFSDNQNLNDFIGHIAFSPLFSPYFPWQKSHKLHHAFTNHIDKDHGHVWIQDKDWEAMPSWKRWFNPIPFSGWLKWFPVYTLFGFCDGSHFWPYSSLFVRNSERVQCVISGICCCVCAYIALTIAGSYSNWFWYYWVPLSFFGLMLVIVTYLQHVDDVAEVYEADEWSFVRGQTQTIDRYYGLGLDTTMHHITDGHVAHHFFNKIPHYHLIEATEGVKKVLEPLSDTQYGYKSQVNYDFFARFLWFNYKLDYLVHKTAGIMQFRTTLEEKAKAK
Protein: T-complex protein 11 (Q587E2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSEPTTPIEPNCLTSSECVRRVAKLLEQLDAAGLRYDPAQPPAPDAVENILITDKWSCRTCGATDVSTCPHTGRPHRRYLVRIAQDILRLIGARTGQFVVRPPKMSSSMDGRSRLRSLRRVTMNPQALLLAYYYAIPSCEEVDSLVTECAQHFLVLLGHLNQYGAQGEVSGEYADALLSSTALMWREYSRRIAEGLDLSKITDRQACKDTLLNATKETYLAVAREIRISPSNECLNAFLQLLRVRLGRVAPQEDLDKLEASDQQQQRYDDDEEQAELNRHGKCSLNRTSLLQSSAPPVLLSEGNTSGSDAEAPSPVAIGPPLPPNWYIDEHGRSRPPQVTEEQRRKERFSRMEFRARKAYETVIKVPEQKDDPLKKEVIAALNDAQLGILAEQCNQQPPDLRNVPSFLNLVVEGLLNALPRRLRSRVEQEVRDVLDWRVVRRSVMGSPGNISVLTRYVMGKVAQYGAPAKSEETLSLAERISEDLEKCLPDLGTAVANAFRVMFSSIRQLHEDVAHYSLLYIAPQLRDNAVPFMREFIVECLPSVEKWESSLAFVRRYFNDERVTAWIASPVAASLTIVTESAKRLRGCLVFGLIDLLRSSGCQPNERWHDYPTECFFFEKPIVFFAANAVQECALLLLLSGTVSTIFRAKGMDSATINGILKQLHDKFRRLLSEQLTLSLLKTCVSDLMRKVLVETKPECVLTDAEVQQLNGAVEKMTDTGSTLYMTFEKRIILFIEAVLARGENDPAPLGLVTDSLKQVAALLQRALTLNWEVYRLVYDGLLSHVEQQEASA
Protein: Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) (P55317)
Organism: Homo sapiens (Human)
Function: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}.
Interaction partners:
- Estrogen receptor
- Trans-acting T-cell-specific transcription factor GATA-3
- Androgen receptor
- Histone deacetylase 7
- Transducin-like enhancer protein 3
- Histone acetyltransferase p300
- Homeobox protein Nkx-2.1
- Nuclear receptor-interacting protein 1
- Hepatocyte nuclear factor 6
- Progesterone receptor
Sequence:
MLGTVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMTPASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQAASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGASNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTAPPISSGPGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSRPVLNTS