wanglab/gogpt-training-data huggingface dataset:
Protein: Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] (P60709)
Organism: Homo sapiens (Human)
Function: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:17289661}. Nucleus {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:29925947}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}.
Interaction partners:
- Profilin-3
- Actin-like protein 6A
- Profilin-1
- Actin, cytoplasmic 2
- Cofilin-1
- Profilin-4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- Cofilin-2
- RuvB-like 2
Sequence:
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
Protein: Importin-9 (Ran-binding protein 9) (Q9VGP4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Nuclear transport receptor that mediates nuclear import of proteins. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (By similarity). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (By similarity). Mediates the import of pre-assembled proteasomes into the nucleus during the late stages of sperm development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:33632744}. Nucleus {ECO:0000269|PubMed:33632744}.
Interaction partners:
- Profilin
- Cofilin/actin-depolymerizing factor homolog
- IP04855p
- Histone H2A.v
- D-Importin 7/RanBP7
- LD21576p
- Artemis, isoform B
- GTP-binding nuclear protein Ran-like
- AT14585p
- Nucleosome assembly protein 1-like 4
Sequence:
MSLQFQNDCGDSVKQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWTDDDDVKRKANGCMASEQAKRTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPHCWAELFDIIVKCLGGNEDSIHGAMQVLQDFSYDVEQIKELGPVVIPEVYRIFDSEQNYSIKTRVSAIRILKPLFASIAALITNKEEQSTMMSSILTNFMDKLMHYLSMNSGAVSSFLLRTEIIKVFTHLVNEMPKYINPFMDRVLPIVWQLLTQIAETYVKVSVNQTETSPLASGDSEEDDEQTNFQSLIIQILEFINCILTCNKLRGSIKNVLADLIYITIVYIQLSEEQLEDWHDDPEKFVDDEDDGGVELTVRMCGRDVLLAINDEFGANAIQPLQEALGRHFSVADAEKAANNPNWWKIQEACMDAVHAFRDVILAGDSTFDLLNYLTIVRNLLVHQESPPLVGRALWTLSIYSKSDLYNPQMLTEILDVTLCSLSPEKSHILRISAVRTLNGFLQANETIDGEKRTLLVSKLPGFLDGIMALVPGSKAAVLALLMEALTFMVKFDAEFAFASQAKITPLAIAVFLKYTEDPYVLETVQDLIKALCQRKECLGPLQEKFIPTIVSILGLTGAASTEKQDIALDVLNTIVRYTEPPLNNSLLETAFPAIINCVLHTDDHAVMVAGGECLRSFINVSPEQICSYKNGEGINCIMQVVATVLLNPMNSEMTAAGQIGRLVITIITKMGSMLGQNVDMLLKAVISKMQNLECLKVIMNLVLIFAHLFLTQMDAVLNFLSTVPGPNGEPAMQFVLTNWLSRQNSFFGNYERKVTTMALCKLFEYGVATQDNRLTTITFKELVDDPTDTRRRTRSVAATTQKWVTIPALVKIFKVLISEYQHFQEGKSDEPLTDSEEDGDDEDAPGNPDKPRYISDLFESDEDNAEDEQLLQELLKETNYQGDIADNLQKFLTTFTQNEHFPTFYEHLTEGERLILLSKVQQK
Protein: Mitotic spindle checkpoint protein MAD2 (Mitotic arrest deficient protein 2) (Q9LU93)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Subcellular location: Nucleus {ECO:0000269|PubMed:19710914, ECO:0000269|PubMed:22457071}. Nucleus envelope {ECO:0000269|PubMed:22457071}. Chromosome {ECO:0000269|PubMed:19710914}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19710914}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19710914}. Cytoplasm {ECO:0000269|PubMed:19710914, ECO:0000269|PubMed:22457071}. Note=Cytoplasmic in interphase cells. Accumulates onto both kinetochores and the spindle microtubules in cell arrested in metaphase. Present in chromocenters. Associates with unattached kinetochores upon spindle assembly checkpoint (SAC) activation. The nucleus envelope association requires the presence of NUA. {ECO:0000269|PubMed:22457071}.
Interaction partners:
- Anaphase-promoting complex subunit 6
- Mitotic spindle checkpoint protein MAD1
- Anaphase-promoting complex subunit 4
- Mitotic spindle checkpoint protein BUBR1
- Anaphase-promoting complex subunit 8
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Anaphase-promoting complex subunit 1
- Mitotic checkpoint protein BUB3.1
- Anaphase-promoting complex subunit 10
- Serine/threonine-protein kinase MPS1
Sequence:
MASKTAAAKDIITLHGSAAIVSEFFCYAANSILYNRAVYPEESFVKVKKYGLPMLLIEDESVKSFMSNLTSQISEWLEAGKLQRVVLVIMSKATGEVLERWNFRIETDNEVVDKGVSREKSDKEIMREIQAIMRQVASSVTYLPCLDETCVFDVLAYTDTDVAVPFTWIESDPKLIANPQMVKLHGFDTKIHKVDTLVSYKNDEWDEEE
Protein: Mitochondrial ribosomal protein S22 (H7C5H3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
GTTVLLWSLLRSSPGVERVCFRARIQPWHGGLLQPLPCSFEMGLPRRRFSSEAASYLLKSILAESGSPETKKPTFMDEEVQSILTKMTGLNLQKTFKPAIQELKPPTYKLMTQAQLEEATRQAVEAAKVRLKMPPVLEERVPINDVLAEDKILEGTETTKYVFTDISYSIPHRERFIVVREPSGTLRKASWEERDRMIQV
Protein: 2-methylcitrate synthase (2-MCS) (MCS) (EC 2.3.3.5) (Citrate synthase) (EC 2.3.3.16) (Q937N9)
Organism: Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha)
Function: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower efficiency.
Interaction partners:
Sequence:
MSEAQPLVTPKPKKSVALSGVTAGNTALCTVGRTGNDLHYRGYDILDIAETCEFEEIAHLLVHGKLPTKSELAAYKAKLKSLRGLPANVKAALEWVPASAHPMDVMRTGVSVLGTVLPEKEDHNTPGARDIADRLMASLGSMLLYWYHYSHNGRRIEVETDDDSIGGHFLHLLHGEKPSALWERAMNTSLNLYAEHEFNASTFTARVIAGTGSDMYSSISGAIGALRGPKHGGANEVAFEIQKRYDNPDEAQADITRRVENKEVVIGFGHPVYTTGDPRNQVIKEVAKKLSKDAGSMKMFDIAEALETVMWDIKKMFPNLDWFSAVSYHMMGVPTAMFTALFVIARTSGWAAHIIEQRIDNKIIRQSANYTGPENLKFVPLKDRK
Protein: Alpha-catulin (Q8T3U1)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAASSMSSLTSSYHTTAMPSSNSVVPPFDARNLEIKTKSIEQTLIPLVTQITTLVNYKESYMASGKPKSERAMRAALKIGSAVEAAIERFVCVGETIADENADIQPEMYDACTEARLAGASMANLSCACNDDPNSVVDKAVLVRASRQLLSSVTRVLLLADRVLVKQVLRAEDKIAFSLSRLESTRSFNDFVKVFAVFGGEMVELAHRSGDRQHDLKSEKRKAQMSIARTSLERLTMLLLTASKTYLRHPDCDSALQCRDGVFYQMKLSLELIAICVCDGILTTEKSRYIQDEPDMPIDIALQLTANAAIKQLTEMLEMIRMTVRVGAGVRERIVSALDALCQLTQDFTDSAYTPHHQREQILDFLEECRFEMTNLIQPDENEQLAASGLEVTVERLNRRLKDLSKQLQIVAMEQISEVLRANEDQVLLSSMKACAVSGDIDGVEKYMHKFREHADHMQEVCRLLHHISITDALHVHTGHVERNMRALAPLTILAGRTLCVHPSSRIARENLEVFCDTWGQAVNDLSRVAKESDVAANGRVAAEKQAYMSLPRPGVSKSSCRRSVPKHDAASSSSSNELLPNGGRHPKQVGIAPTRVVSQTGDEASSDEEQVDKQEIEAFQYRISLIIDDLQSDVEGGTHGR
Protein: Flagellar hook-associated protein 1 (HAP1) (P0A1J5)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Subcellular location: Secreted {ECO:0000250}. Bacterial flagellum {ECO:0000250}.
Interaction partners:
- Flagellar basal-body rod protein FlgC
- Flagellar basal-body rod protein FlgG
- Flagellar hook-associated protein 2
- Flagellar secretion chaperone FliS
- Peptidoglycan hydrolase FlgJ
- Flagellar basal body rod protein FlgB
- Flagellar hook protein FlgE
- Flagellar hook-associated protein 3
- Basal-body rod modification protein FlgD
- Flagella synthesis protein FlgN
Sequence:
MSSLINHAMSGLNAAQAALNTVSNNINNYNVAGYTRQTTILAQANSTLGAGGWIGNGVYVSGVQREYDAFITNQLRGAQNQSSGLTTRYEQMSKIDNLLADKSSSLSGSLQSFFTSLQTLVSNAEDPAARQALIGKAEGLVNQFKTTDQYLRDQDKQVNIAIGSSVAQINNYAKQIANLNDQISRMTGVGAGASPNDLLDQRDQLVSELNKIVGVEVSVQDGGTYNLTMANGYTLVQGSTARQLAAVPSSADPTRTTVAYVDEAAGNIEIPEKLLNTGSLGGLLTFRSQDLDQTRNTLGQLALAFADAFNAQHTKGYDADGNKGKDFFSIGSPVVYSNSNNADKTVSLTAKVVDSTKVQATDYKIVFDGTDWQVTRTADNTTFTATKDADGKLEIDGLKVTVGTGAQKNDSFLLKPVSNAIVDMNVKVTNEAEIAMASESKLDPDVDTGDSDNRNGQALLDLQNSNVVGGNKTFNDAYATLVSDVGNKTSTLKTSSTTQANVVKQLYKQQQSVSGVNLDEEYGNLQRYQQYYLANAQVLQTANALFDALLNIR
Protein: Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) (Q01658)
Organism: Homo sapiens (Human)
Function: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Subcellular location: Nucleus.
Interaction partners:
- Dr1-associated corepressor
- TATA-box-binding protein
- MAP3K12-binding inhibitory protein 1
- YEATS domain-containing protein 2
- WD repeat-containing protein 5
- Transcriptional adapter 2-alpha
- Transcriptional adapter 3
- DNA polymerase epsilon subunit 3
- SAGA-associated factor 29
- Cysteine-rich protein 2-binding protein
Sequence:
MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI
Protein: Elongation factor 1-alpha (EF-1-alpha) (Eukaryotic elongation factor 1A) (eEF1A) (Translation elongation factor 1A) (P02994)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GTP-binding component of the eukaryotic elongation factor 1 complex (eEF1). In its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled by its guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) before binding another molecule of aminoacyl-tRNA. Required for nuclear export of aminoacyl-tRNAs. May also be involved in translational quality control by targeting cotranslationally damaged proteins to the proteasome. Also exhibits actin filament-binding and -bundling activities and is involved in cytoskeleton organization. Plays a role as a negative regulator of GCN2 kinase activity by inhibiting GCN2-mediated eIF-2-alpha phosphorylation in amino acid-repleted cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Elongation factor 1-beta
- Elongation factor 1-gamma 1
- Elongation factor 1-gamma 2
- U3 small nucleolar RNA-associated protein 20
- Ribosome biogenesis protein BMS1
- Elongation factor 3A
- Eukaryotic peptide chain release factor subunit 1
- Actin
- GTP-binding nuclear protein GSP1/CNR1
- Glyceraldehyde-3-phosphate dehydrogenase 3
Sequence:
MGKEKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGVGEFEAGISKDGQTREHALLAFTLGVRQLIVAVNKMDSVKWDESRFQEIVKETSNFIKKVGYNPKTVPFVPISGWNGDNMIEATTNAPWYKGWEKETKAGVVKGKTLLEAIDAIEQPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKPGMVVTFAPAGVTTEVKSVEMHHEQLEQGVPGDNVGFNVKNVSVKEIRRGNVCGDAKNDPPKGCASFNATVIVLNHPGQISAGYSPVLDCHTAHIACRFDELLEKNDRRSGKKLEDHPKFLKSGDAALVKFVPSKPMCVEAFSEYPPLGRFAVRDMRQTVAVGVIKSVDKTEKAAKVTKAAQKAAKK
Protein: Protein phosphatase inhibitor 2 (IPP-2) (P11845)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Inhibitor of protein-phosphatase 1.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Serine/threonine-protein phosphatase
- Lysozyme E
Sequence:
MAASTASHRPIKGILKNKTSSTSSRVASAEQPRGSVDEELSKKSQKWDEMNILATYHPADKDYGLMKIDEPSTPYHSMIGDDDDAYSDTETTEAMTPDTLAKKLAAAEGSEPKYRIREQESSGEEDSDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQLISKDLHDDEEDEEMSETADGESMNTEESNQGSTPSDQRQNKSQSS
Protein: Srp40 C-terminal domain-containing protein (Q581A7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nucleolar RNA binding protein, putative
- Nucleolar protein 56
- Centromere/microtubule binding protein cbf5, putative
- DNA-directed RNA polymerase subunit beta
- Fibrillarin, putative
- Fibrillarin, putative
- rRNA 2'-O-methyltransferase fibrillarin
- CCAAT-binding factor domain-containing protein
- Ribosomal protein L1p/L10e family
- DNA-directed RNA polymerase I subunit RPA1
Sequence:
MPVTVEEVVLRYLEATCPSAAEAFKNRVPLQNHQEKNQNNASGAIIEDAVRLYNNQETSVHTDEENEPLYKLLGKRIAEDCDVKKSEQARKKARTETSENKRKAKDIENKGKVTPKKPVAPESSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDEPVRKPLLKANSSPKSNAAVKKPVAPDSSSDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDEPVRKPLLKANSSPKSNAAVKKPVAPDSSSDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLLKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPESSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPESSSDDDEPVRKPLVKANSSPKSNAAVKKPVAPESSSDDDDEPVRKPLLKANSSPKSNAAVKKPVASESSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPESSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLLKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVASESSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPESSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPESSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDDEPVRKPLVKANSSPKSNAAVKKPVAPDSSSDDDEPVRKPLVKANSSPKSNAAVKKPVAPESSSDVVEDFGVTGRKRSLSHYEGESEEILRKVPRVEAVDSYRRDRKQPVVGKCDDFSVRGSGSVRRPFQRIDPTKVAFASNDLRDNGPKAEHMALRQNQEMMRVKGKSFNKLKQKNKAKLYASGVDVSVRSFQFEDSE
Protein: Protein FLOWERING LOCUS T (Q9SXZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the mobile flower-promoting signal (floral stimulus or florigen). Promotes the transition from vegetative growth to flowering. Required for 'SEPALLATA3' (SEP3) and 'FRUITFULL' (FUL) accumulation in mature rosette leaves. Seems to acts in parallel with 'LEAFY' to induce flowering by regulating 'APETALA1'. Translated in leaves and then transported to the shoot apical meristem where it activates the transcription of several floral meristem identity genes. May play a role in both the autonomous and the long-day flowering pathways.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16099979}. Nucleus {ECO:0000269|PubMed:16099979, ECO:0000269|PubMed:22529749}. Endoplasmic reticulum {ECO:0000269|PubMed:22529749}.
Interaction partners:
- UPF0235 protein At5g63440
- Protein FD
- Protein TWIN SISTER of FT
- Zinc finger protein CONSTANS
- Small ribosomal subunit protein mS29
- Floral homeotic protein APETALA 1
- Large ribosomal subunit protein mL46
- At1g64880
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein uL23m
Sequence:
MSINIRDPLIVSRVVGDVLDPFNRSITLKVTYGQREVTNGLDLRPSQVQNKPRVEIGGEDLRNFYTLVMVDPDVPSPSNPHLREYLHWLVTDIPATTGTTFGNEIVCYENPSPTAGIHRVVFILFRQLGRQTVYAPGWRQNFNTREFAEIYNLGLPVAAVFYNCQRESGCGGRRL
Protein: Cytochrome c oxidase copper chaperone (Q57XD6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Interaction partners:
Sequence:
MGIETWKVFPSILTEYPKHGVPLPCSDQNPRLKCPETRWARDFCLAQGGNCEYKIEAHFDCLEQYYPPEKVMQLRKAFKPNTLDYPTSDTYIRYRHFYIGAGWMGGKRGWEGTA
Protein: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (P63218)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Di-N-acetylchitobiase
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MSGSSSVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAQHDPLLTGVSSSTNPFRPQKVCSFL
Protein: Leucine-rich HEV glycoprotein (Leucine-rich alpha-2-glycoprotein) (Q91XL1)
Organism: Mus musculus (Mouse)
Interaction partners:
- Endoglin
- Haptoglobin
Sequence:
MVSWQHQGSLQDLKTCLARTLFLLALLGRVSSLKECLILQSAEGSTVSCHGPTEFPSSLPADTVHLSVEFSNLTQLPAAALQGCPGLRELHLSSNRLQALSPELLAPVPRLRALDLTRNALRSLPPGLFSTSANLSTLVLRENQLREVSAQWLQGLDALGHLDLAENQLSSLPSGLLASLGALHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNRLQRLEDSLLAPQPFLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGLWAFLGRPTRDMQDGFDISHNPWICDKNLADLCRWLVANRNKMFSQNDTRCAGPEAMKGQRLLDVAELGSL
Protein: Transcription factor (E5KUH3)
Organism: Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)
Interaction partners:
Sequence:
MSISVNGQSQVPPGFRFHPTEEELLHYYLRKKVSYEKIDLDVIRDVDLNKLEPWDIQERCKIGTTPQNDWYFFSHKDKKYPTGTRTNRATAAGFWKATGRDKVIYSTGKRIGMRKTLVFYKGRAPHGQKSDWIMHEYRLDDSTSDTNVSNVMEEEAAQEEGWVVCRIFKKKNLNKTLDKPFSSSPISADTRNQMLSSCDEGTIDQTFHYMGRTCKEENVADNSATARYLRPVDTAINYVHHDGFMKLPSLESPNSISSQNCYQPMITDNEGSITNQMSYPLDPGLDNWATLDRLFAYQLNGQTETSRQLPCIDPTITYCTPSTDLHHDLRLPTLRSSFPLPSNRSYHGTQDYNNEIDLWNFTTRSSPDTLCQLSNTGA
Protein: XK-related protein 4 [Cleaved into: XK-related protein 4, processed form] (Q5GH67)
Organism: Mus musculus (Mouse)
Function: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25231987}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- DGAT1/2-independent enzyme synthesizing storage lipids
Sequence:
MAAKSDGRLKMKKSSDVAFTPLQNSDNSGSVQGLAPGLPSGSGAEDTEAAGGGCCPDGGGCSRCCCCCAGSGGSAGSGGSGGGGRGSGAGSAALCLRLGREQRRYSLWDCLWILAAVAVYFADVGTDIWLAVDYYLRGQRWWFGLTLFFVVLGSLSVQVFSFRWFVHDFSTEDSSTTTTSSCQQPGADCKTVVSSGSAAGEGEVRPSTPQRQASNASKSNIAATNSGSNSNGATRTSGKHRSASCSFCIWLLQSLIHILQLGQIWRYLHTIYLGIRSRQSGESGRWRFYWKMVYEYADVSMLHLLATFLESAPQLVLQLCIIVQTHSLQALQGFTAAASLVSLAWALASYQKALRDSRDDKKPISYMAVIIQFCWHFFTIAARVITFALFASVFQLYFGIFIVLHWCIMTFWIVHCETEFCITKWEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENTALSALWYLYKAPQIADAFAIPALCVVFSSFLTGVVFMLMYYAFFHPNGPRFGQSPSCACDDPATAFSLPPEVATSTLRSISNNRSVASDRDQKFAERDGCVPVFQVRPTAPPTPSSRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAILAFECSPSPPRLQYKDDALIQERLEYETTL
Protein: Proliferating cell nuclear antigen (B5X3H8)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU000641}.
Interaction partners:
- Replication factor C subunit 3
- Flap endonuclease 1
- Replication factor C subunit 4
- DNA mismatch repair protein
- DNA ligase
- DNA polymerase delta subunit 2
- DNA 3'-5' helicase
- DNA polymerase eta
- DNA mismatch repair protein
- Replication factor C subunit 2
Sequence:
MFEARLVQGSILKKVLEALKDLITEACWDVSSSGISLQSMDSSHVSLVQLTLRSDGFDSYRCDRNLAMGVNLSSMSKILKCAGNEDIITLRAEDNADTLALVFETLNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVRMPSGEFARICRDLSQIGDAVMISCAKDGVKFSATGELGTGNVKLSQTSNVDKEEEAVSIEMNEPVQLIFALNYLNFFTKATPLSKTVILSMSADIPLVVEYKIADMGHVKYYLAPKIDEEAS
Protein: Deoxyribodipyrimidine photo-lyase (EC 4.1.99.3) (AtCPDII) (DNA photolyase) (Photoreactivating enzyme 1) (Protein UV RESISTANCE 2) (Q9SB00)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutylpyrimidine dimers (CPDs), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. Required for plant survival in the presence of UV-B light. Not involved in the repair of (6-4) photoproducts.
Subcellular location: Nucleus {ECO:0000269|PubMed:19521716}.
Interaction partners:
- 
- Cryptochrome DASH, chloroplastic/mitochondrial
- Timeless family protein
- DNA repair endonuclease UVH1
- Cryptochrome-2
- Cryptochrome-1
- DNA excision repair protein ERCC-1
- Probable F-box protein At4g23960
- F-box protein SKIP8
- Nuclear transport factor 2
Sequence:
MASTVSVQPGRIRILKKGSWQPLDQTVGPVVYWMFRDQRLKDNWALIHAVDLANRTNAPVAVVFNLFDQFLDAKARQLGFMLKGLRQLHHQIDSLQIPFFLLQGDAKETIPNFLTECGASHLVTDFSPLREIRRCKDEVVKRTSDSLAIHEVDAHNVVPMWAASSKLEYSARTIRGKINKLLPDYLIEFPKLEPPKKKWTGMMDKKLVDWDSLIDKVVREGAEVPEIEWCVPGEDAGIEVLMGNKDGFLTKRLKNYSTDRNNPIKPKALSGLSPYLHFGQVSAQRCALEARKVRSTSPQAVDTFLEELIVRRELSDNFCYYQPHYDSLKGAWEWARKSLMDHASDKREHIYSLEQLEKGLTADPLWNASQLEMVYQGKMHGFMRMYWAKKILEWTKGPEEALSISIYLNNKYEIDGRDPSGYVGCMWSICGVHDQGWKERPVFGKIRYMNYAGCKRKFNVDSYISYVKSLVSVTKKKRKAEEQLTRDSVDPKITIV
Protein: MYB proto-oncogene like 2 (D3ZLC6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Lin-9 DREAM MuvB core complex component
- Protein lin-52 homolog
- Lin-37 DREAM MuvB core complex component
- Protein lin-54 homolog
- RB-binding protein 4, chromatin-remodeling factor.
- RB binding protein 4, chromatin remodeling factor like 1
- Cyclin-A2
- Cyclin-A1
- Cyclin-dependent kinase 2
- Forkhead box protein M1
Sequence:
MSRRTRCEELDELRYQDTDSDLLEQRDNKCKVKWTHEEDELLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFPNESRDCKPVYLLLELEDKDYQQNVQPVEGPGSLVSSWPLAPSTVKEEESSEEEAAVATTSKEHKQEPVPTDLGEVRTPEPLEFLKREYQEESSPETSLPYKWVVEAANLLIPAVESSLSEALDLIESDPDAWCDLSKFDLPEEPSAEGSVNSSPVQLQTPQQQQQHQQALSFHQAATPGPSVTEYRLDGHTISDLSRSSRGELIPISPSTEFGGSGIGTPPSVLKRQKKRRVALSPVTENSASLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKYPSFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGIELIIEDDMRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDGKMMSSTSPKTLSLPTSVPSSSSGFILPGIKEDNSLLNQGFLQAKPEKVVATQKPRSHIPAPAPMTRAWKTVACGGTKDQLFMQEKARQLLGRLKSSHTSRTLILS
Protein: Hematopoietically-expressed homeobox protein Hhex (Homeobox protein HEX) (mHex) (Homeobox protein PRH) (Proline-rich homeodomain protein) (P43120)
Organism: Mus musculus (Mouse)
Function: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Activator of WNT-mediated transcription in conjunction with CTNNB1. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. May play a role in hematopoietic differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:23665349}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q03014}. Cytoplasm {ECO:0000250|UniProtKB:Q03014}.
Interaction partners:
- Threonylcarbamoyladenosine tRNA methylthiotransferase
- Proton-coupled zinc antiporter SLC30A8
- Hepatocyte nuclear factor 6
- Hepatocyte nuclear factor 3-gamma
- Insulin-like growth factor 2 mRNA-binding protein 2
- Transcription factor 7-like 2
Sequence:
MQFPHPGPAAAPAVGVPLYAPTPLLQPAHPTPFYIDDILGRGPAAPTPTPTLPSPNSSFTSLVSSYRTPVYEPTPVHPAFSHHPAAALAAAYGPSGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTVELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKDALDSLDTSCEQGQDLPSEQNKGASLDRSQCSPSPASQEDPDSEISEDSDQEVDIEGDKGYFNAG