wanglab/gogpt-training-data huggingface dataset:
Protein: Biogenesis of lysosome-related organelles complex 1 subunit KXD1 (BLOC-1 subunit KXD1) (KxDL homolog) (P53158)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
Subcellular location: Endosome {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit BLI1
- Biogenesis of lysosome-related organelles complex 1 subunit VAB2
- Biogenesis of lysosome-related organelles complex 1 subunit CNL1
- Biogenesis of lysosome-related organelles complex 1 subunit SNN1
- Biogenesis of lysosome-related organelles complex 1 subunit BLS1
- Kelch repeat-containing protein 3
- Membrane protein TMS1
Sequence:
MVTGISEENDDEETFSAVHSSTPSINSQSYAIPITEEMSSSFHDSISTTSNSSGSFDSDGSNVSDVVEQNEMDNESNVDEDLFLDNDIPQSSNLLPTDAQDPGPIFDVSRYIFDSLKQSIDSADFSEALSLQTKTSAVINSKSLELKQYIDEMKSRLTQLQEKFENGEATSKKIKRDLETSRKNIDYLNAALRVDFPIEFNQAREKILERRLNEDHDC
Protein: Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC-1 subunit 4) (Protein cappuccino homolog) (Q9NUP1)
Organism: Homo sapiens (Human)
Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Dysbindin
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- SNARE-associated protein Snapin
- BLOC-2 complex member HPS6
- BLOC-2 complex member HPS3
- BLOC-2 complex member HPS5
Sequence:
MEGSFSDGGALPEGLAEEAEPQGAAWSGDSGTVSQSHSSASGPWEDEGAEDGAPGRDLPLLRRAAAGYAACLLPGAGARPEVEALDASLEDLLTRVDEFVGMLDMLRGDSSHVVSEGVPRIHAKAAEMRRIYSRIDRLEAFVRMVGGRVARMEEQVTKAEAELGTFPRAFKKLLHTMNVPSLFSKSAPSRPQQAGYEAPVLFRTEDYFPCCSERPQL
Protein: Ataxin 2 (A0A5F9ZHX3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGVFILSFISFVLSGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL
Protein: Light-mediated development protein DET1 (Deetiolated1 homolog) (High pigmentation protein 2) (Protein dark green) (tDET1) (Q9ZNU6)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Component of light signal transduction machinery. Involved in fruit pigmentation and fruit nutritional quality. Acts as a negative regulator of fruit pigmentation. Probably acts by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes. Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA damage-binding protein 1
- Cullin-4
- RING-type domain-containing protein
- Cullin-4
- Uncharacterized protein
- Ubiquinol oxidase
- DNA damage-binding protein 1
- Transcription factor HY5
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MFKTNNVTARLFERQICTPAPGTSIHRARRFYENVVPSYTIYDVECPDHSFRKFTDDGLYFVSFSRNHQDLVVYRPTWLTFSCKEEDCDTHDLPLKARKFESFFTQLYSVTLASSGELICKDFFLYMESNQFGLFATSTAQIHDAPPTGGAIQGVPSVEKITFHLLRLVDGAILDERVFHNDYVNLAHSIGAFLYDDLLAIVSLRYQRIHILQIRDSGDLVDVRAIGEFCREDDELFLNSNSQVLVNHVGNGFHHSLPQSETSFLSGIKQRLLSYIFRGIWNEADQTMRVQCLKKKFYFHFQDYIDLIIWKVQFLDRHHLLIKFGSVDGGVSRNADIHPSFFAVYNMETTEIVAFYQNSADELYFLFELFSDHFHVSSKSSLHMNFMSSHSNNIHALEQLRCTKNKATNFSQFVKKMMASLPCSCQSQSPSPYFDQSLFRFDEKLISAIDRHRQSTDHPIKFISRRQPNILKFKMKPGPEAGSTDGRTKKICSFLFHPILPLALSVQQTLFLQASVVNIHFRR
Protein: Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B) (Q86UV7)
Organism: Homo sapiens (Human)
Interaction partners:
- Gamma-butyrobetaine dioxygenase
Sequence:
MAWQVSLLELEDRLQCPICLEVFKESLMLQCGHSYCKGCLVSLSYHLDTKVRCPMCWQVVDGSSSLPNVSLAWVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVCSRMKEELAALFSELKQEQKKVDELIAKLVKNRTRIVNESDVFSWVIRREFQELRHPVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHEFIWKFHSMASR
Protein: Tachykinin-related peptide 4 (TKRP-4) (P86560)
Organism: Acrosternum hilare (Green stink bug) (Nezara hilaris)
Subcellular location: Secreted {ECO:0000269|PubMed:19084564, ECO:0000305}.
Interaction partners:
Sequence:
SPASGFFGMR
Protein: Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein) (A8WGB1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Vascular endothelial growth factor C
- ADAM metallopeptidase with thrombospondin type 1 motif, 3.
- Vascular endothelial growth factor receptor 3
- C-fos induced growth factor
- SRY-box transcription factor 18
- Lymphatic vessel endothelial hyaluronic receptor 1b
- ADAM metallopeptidase with thrombospondin type 1 motif, 14.
- Prospero homeobox 1a
- Epidermal growth factor.
- Integrin alpha-9
Sequence:
MIYPGRGASLSVAVALVLFSSGAPWTFREEKEDVDREVCSESKIATTKYPCVKSTGEVTTCYRKKCCEGFKFVLGQCIPEDYDVCAGAPCEQQCTDHFGRVVCTCYDGYRYDRERHRNREKPYCLDIDECANNNETVCSQMCVNTPGSYRCDCHSGFYLEDDGKTCTKGERAPLFEKSDNVMKEGTCSATCEDFHQMKMTVLQLKQKMSLLSSNTEINKQMTNEKMMMTTNSFLPGPPGPPGPAGTPGAKGSSGSPGQMGPPGLPGPRGDMGPIGPSPDLSHIKQGRRGPVGPPGAPGRDGMKGERGFPGPSGPPGPPGSFDFLLLMMADIRNDIAELQSKVFSRPLHSSFEDFPSAPDSWRDTPENLDFGSGEDYKSQSPPKSSRKRKLPRNLKNPDWPV
Protein: LD27861p (Suppressor of variegation 2-10, isoform E) (Zimp-B) (Q9XYM5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLELLAPKVQEVYAQSVQEQNATLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSETVDLTLSDSDDDMPLAKRRPPAKQAVASSTSNGSGGGQRAYTPAQQPQQSGTLDPFLQ
Protein: Protein YELLOW LEAF 1, choloroplastic (Q0E3V2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Required for photosynthetic protein complex assembly in chloroplast thylakoid membranes during leaf development. Maintains the abundance of the core protein complex PsaA-PsaB of photosystem I (PSI) in the thylakoid membrane. May play a role in the efficient biogenesis of the chloroplast ATP synthase complex, possibly by interacting with the beta subunit atpB.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:27585744}.
Interaction partners:
Sequence:
MPPLATMSSPGSLLLLTPAVYQGIGRNRGGQSQEGQSISSSRSLKTKLSVSARAVSSCEASMRITCCANQTQTARRKSFSGPTSPPSGSVKEKVRSPKLDDGGTGFPPFRFGGGGGGGGGGGSNSAGGFILFVIVLLLDYLREFERNLQNGTRRGSDYDNGLAPQ
Protein: Fructan hydrolase (Q5H7T0)
Organism: Lacticaseibacillus casei (Lactobacillus casei)
Interaction partners:
Sequence:
MDEKKHYKMYKSKSVWVFACLSTCLIVSFFNDGQNVSAATSASSTQISQTNTGSQPNNETTGETAQSSVNSTATASSSSVADLPSSSDSKSSIGSTISQPTVDKKETSKSDTADNDLTKSVTTSDSDKALPTSKTTLPTSNEQVQSSVGQSQTDQSASSATIATNAVTSDVSQNDQYNEPYRNQYHYSSSQNWINDPNGLFYDSKTGLYNLYYQYNPEGNQWGNMSWGHAVSKDLINWTQEDVAIPMLQNQGWEDFTYTNTTGSLKDKGEVRYVGVPTTNWGDADGKKAIFSGSIVVDTNNVSGLGKDAILAFYTADYQIATRKNDGAEDGWGTWIGLTEIQEQHLAYSLDGGKTFIQYSKDGNAANPQAIIPTSMNQGGDAANFRDPSVVYDAVNKQYYLTVVSGQQALIYKSSNLLDWTYASKIERENDVGNGVWECPSLVPMKVAGTNETKWVFCISVQQGAHATGSGMQYYVGNMTADGTWVPESSKTLQNPMTMDSGEDFYAGIPFSNMPDGRTVMLAWQSNWSYVDEAKTSPWSGNMTLPRELSLKKNADTTDGYLLTNTVVKEIANNEEANVINKAESNFTVSRSDEQVQYEGKQYKISATFSWDEADKPKSVGFKLRVSDDQKYDMIVGYDLTTGLLYVQRLNTGEPNMGAPRDKMNATVNADGSITITVYVDETSIEAFANDGEKSITQNFFMRPENIGDQATTGVYVYSNDGTTKISDLTINPITSIWNSTGQLTEKFVDENGNTIASDKIQTGRVGQSYTSESATIPGYVFVKENTDHINSNQLYTTQNQTITYTYRASQASVVTKDTTLAAGPSAAWNAADNLVGATDADGNALAVSDLTVNGAVDPKTPGTYTVTYSYTDATGNKISKKATVTVIASKADIVTKDTTMVAGASTIWNAADNFVEAKNADGNALTVSDLMINGTVDSKTPGTYTVTYSYTDAAGNKINKEAIVTVIASKADIVTKDTTMVAGPSAAWNAVDNFVEATGADGNALALSDLTVNGAVDPKTPGTYTVTYSYTDVAGNKISKEAIVTVIASKADIVTKDTTKVAGPSATWNAADNLVIATDAKGNALALSNLTVTGSVDSKTPGTYTVTYSYTDAAGNKISKEATVTVIASKADIVTKDTTMVAGPSAAWNAANNLVSATDADGNALAMSNLTVTGTVDLKTQGTYTVTYTYTDVAGNKISKEATVTVLTEKETNIEDNTGSSISNDRENPPASITGKGGDDIHQNAKTTMTKKKTETLPQAGNHVNELAIVLGQMILAICVGGILWLKRRVKRV
Protein: Zinc finger protein basonuclin-1 (Q01954)
Organism: Homo sapiens (Human)
Function: Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles. Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade. May also play a role in the early development of embryos (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16891417, ECO:0000269|PubMed:30010909, ECO:0000269|PubMed:8034748, ECO:0000269|PubMed:9223293}. Cytoplasm {ECO:0000269|PubMed:9223293}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16891417}. Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids. {ECO:0000250|UniProtKB:O35914}.
Interaction partners:
Sequence:
MRRRPPSRGGRGAARARETRRQPRHRSGRRMAEAISCTLNCSCQSFKPGKINHRQCDQCKHGWVAHALSKLRIPPMYPTSQVEIVQSNVVFDISSLMLYGTQAIPVRLKILLDRLFSVLKQDEVLQILHALDWTLQDYIRGYVLQDASGKVLDHWSIMTSEEEVATLQQFLRFGETKSIVELMAIQEKEEQSIIIPPSTANVDIRAFIESCSHRSSSLPTPVDKGNPSSIHPFENLISNMTFMLPFQFFNPLPPALIGSLPEQYMLEQGHDQSQDPKQEVHGPFPDSSFLTSSSTPFQVEKDQCLNCPDAITKKEDSTHLSDSSSYNIVTKFERTQLSPEAKVKPERNSLGTKKGRVFCTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMNRNNRDKDLRNSLNLASSENYKCPGFTVTSPDCRPPPSYPGSGEDSKGQPAFPNIGQNGVLFPNLKTVQPVLPFYRSPATPAEVANTPGILPSLPLLSSSIPEQLISNEMPFDALPKKKSRKSSMPIKIEKEAVEIANEKRHNLSSDEDMPLQVVSEDEQEACSPQSHRVSEEQHVQSGGLGKPFPEGERPCHRESVIESSGAISQTPEQATHNSERETEQTPALIMVPREVEDGGHEHYFTPGMEPQVPFSDYMELQQRLLAGGLFSALSNRGMAFPCLEDSKELEHVGQHALARQIEENRFQCDICKKTFKNACSVKIHHKNMHVKEMHTCTVEGCNATFPSRRSRDRHSSNLNLHQKALSQEALESSEDHFRAAYLLKDVAKEAYQDVAFTQQASQTSVIFKGTSRMGSLVYPITQVHSASLESYNSGPLSEGTILDLSTTSSMKSESSSHSSWDSDGVSEEGTVLMEDSDGNCEGSSLVPGEDEYPICVLMEKADQSLASLPSGLPITCHLCQKTYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRSRNRHSQNPNLHKSLASSPSHLQ
Protein: Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolase (PRA-CH) (EC 3.5.4.19); Phosphoribosyl-ATP pyrophosphatase (PRA-PH) (EC 3.6.1.31)] (P06989)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm.
Interaction partners:
- Histidinol-phosphate aminotransferase
- 1-
- Histidine biosynthesis bifunctional protein HisB
- Imidazole glycerol phosphate synthase subunit HisF
- Histidinol dehydrogenase
- Imidazole glycerol phosphate synthase subunit HisH
- ATP phosphoribosyltransferase
- Tryptophan biosynthesis protein TrpCF
- Phosphoserine phosphatase
- Phosphatidylglycerophosphatase C
Sequence:
MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ
Protein: Yop proteins translocation lipoprotein J (Lipoprotein YlpB) (Low calcium response locus protein KA) (P69972)
Organism: Yersinia pestis
Function: Required for the export process of the Yop proteins.
Subcellular location: Cell outer membrane {ECO:0000250}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
Sequence:
MKVKTSLSTLILILFLTGCKVDLYTGISQKEGNEMLALLRQEGLSADKEPDKDGKIKLLVEESDVAQAIDILKRKGYPHESFSTLQDVFPKDGLISSPIEELARLNYAKAQEISRTLSEIDGVLVARVHVVLPEEQNNKGKKGVAASASVFIKHAADIQFDTYIPQIKQLVNNSIEGLAYDRISVILVPSVDVRQSSHLPRNTSILSIQVSEESKGHLIGLLSLLILLLPVTNLAQYFWLQRKK
Protein: Aflatoxin B1 aldehyde reductase member 2 (rAFAR2) (EC 1.1.1.n11) (Succinic semialdehyde reductase) (SSA reductase) (Q8CG45)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Acts as a 2-carboxybenzaldehyde reductase.
Subcellular location: Mitochondrion {ECO:0000255}. Golgi apparatus, Golgi stack {ECO:0000269|PubMed:12071861}. Cytoplasm {ECO:0000269|PubMed:12071861}. Note=Its association with the Golgi stack may facilitate secretion of GHB. {ECO:0000303|PubMed:12071861}.
Interaction partners:
- Aldo-keto reductase family 7 member A3
- Aldo-keto reductase family 1 member A1
- aldose reductase
- Aldo-keto reductase family 1, member C1
- Succinate-semialdehyde dehydrogenase, mitochondrial
- Aldo-keto reductase family 1 member C18
- Aldo-keto reductase family 1 member B1
Sequence:
MLRAVSRAVSRAAVRCAWRSGPSVARPLAMSRSPAPRAVSGAPLRPGTVLGTMEMGRRMDASASAATVRAFLERGLNELDTAFMYCDGQSESILGSLGLGLGSGDCTVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHGTPIVETLQACQQLHQEGKFVELGLSNYASWEVAEIYTLCKSNGWILPTVYQGMYNATTRQVETELLPCLRYFGLRFYAYNPLAGGLLTGKYRYEDKDGKQPEGRFFGNSWSETYRNRFWKEHHFEAIALVEKALKTTYGTSAPSMTSAALRWMYHHSQLQGTRGDAVILGMSSLEQLEQNLAATEEGPLEPAVVEAFNQAWNVVAHECPNYFR
Protein: Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (R4GMX3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- E3 ubiquitin-protein ligase RING2
- Polyhomeotic-like protein 1
- E3 ubiquitin-protein ligase RING1
- Chromobox protein homolog 2
- E3 SUMO-protein ligase CBX4
- Chromobox protein homolog 7
- Chromobox protein homolog 1
- Chromobox protein homolog 8
- Polycomb group RING finger protein 2
- Histone-lysine N-methyltransferase EZH2
Sequence:
MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLKHCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGRTLIPHPIQRLVLVAAWNNYRIFYQAEMHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADEDKRIITDDEIISLSIEFFDQNRLDRKVNKDKEKSKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSNSPSGNHQSSFANRPRKSSVNGSSATSSG
Protein: DDB1- and CUL4-associated factor 12 homolog (Q9VGE3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. Required for synaptic function and plasticity at larval neuromuscular junctions (NMJs) by promoting neurotransmitter release. The DCX(DCAF12) complex catalyzes ubiquitination and degradation of yorkie (yki), thereby regulating the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a regulator of tissue growth during development: required for the apoptotic elimination of supernumerary cells during metamorphosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:30670470}. Nucleus {ECO:0000269|PubMed:30670470}. Presynapse {ECO:0000269|PubMed:30670470}. Note=Mainly localizes to presynapses in larval neuromuscular junctions. {ECO:0000269|PubMed:30670470}.
Interaction partners:
- DNA damage-binding protein 1
- Cullin-4A
- Uncharacterized protein
- WD repeat-containing protein 37
- Uncharacterized protein, isoform A
- RING-box protein 1A
- F-box and WD repeat domain containing 5
Sequence:
MFNGMVRTIRDSVVGTYPSCHVSSRLEERRAKQRAMRQERRRKPDKPDDFVTYEDSGSDEETPQQQEEVLNTSYNLCDYLRSRESGLRDRRSVNVEYTSRYVLTHDMLRETQISLGYINKVFCSKWLSSRQVVFGTKCNKLLVYDVNMRRVDAIPTLSNSRANHPEVQGGLHAIELSPSRSFLATGARNSSDIAVYRLPTLDPVCVGEGGHRDLIMGMCWLDDQFLVSGSKDSRMALWRINEDHMEFPDGGEEACPTFATIHPLSVKEVRTAQRIRSLCFNKEFKEIAALSLNGYIHIFNAETFKQTLSRKLPNCQDNVSIAYHSDGLYAVGCRSYTILLDARTLQTIKKITSRYSGCGIRATSFEGNLLTVGTGLGMLLFYDIRAGKYLESSVNASRTVALKCSKGIVYPEDEMDGFQQVKYVPAIYTHCYDSTRMRLFAAGGPLPATLVGNYAGVWQ
Protein: Small archaeal modifier protein 2 (SAMP2) (Ubiquitin-like small archaeal modifier protein 2) (D4GZE7)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: Functions as a protein modifier covalently attached to lysine residues of substrate proteins, as well as a sulfur carrier in tRNA thiolation. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP2 C-terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. Is able to form polymeric chains with itself at Lys-58, similar to ubiquitin and other ubiquitin-like proteins. May serve as a proteolytic signal in the cell to target proteins for degradation by proteasomes.
Interaction partners:
- SAMP-activating enzyme E1
- Thiamine-phosphate synthase
- Phosphomethylpyrimidine synthase
- Phosphomethylpyrimidine kinase / phosphomethylpyrimidine phosphate kinase
- Desampylase
- tRNA 2-thiolation protein NcsA
- Small archaeal modifier protein 1
- GNAT family acetyltransferase
- 5-amino-6-
- 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
Sequence:
MNVTVEVVGEETSEVAVDDDGTYADLVRAVDLSPHEVTVLVDGRPVPEDQSVEVDRVKVLRLIKGG
Protein: Frizzled-10 (Fz-10) (CD antigen CD350) (Q8BKG4)
Organism: Mus musculus (Mouse)
Function: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15923619}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein Wnt-7a
- Proto-oncogene Wnt-1
- Protein Wnt-11
- Protein Wnt-7b
- Tyrosine-protein kinase RYK
- E3 ubiquitin-protein ligase RNF43
- E3 ubiquitin-protein ligase ZNRF3
- Low-density lipoprotein receptor-related protein 5
- Protein Wnt-3a
- Low-density lipoprotein receptor-related protein 6
Sequence:
MQHPGPRLWLVLQVMIGSCTAISSMDLERPGDGKCQPVEIPMCKDIGYNTTRMPNLMGHENQREAAIQLHEFAPLVEYGCHSHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFKFRWPDSLDCSKLPNKNDPNYLCMEAPNNGSDEPSRGSGMFPPLFRPQRPHSAQEHPLKDGGPGRAGCDNPGKFHHVEKSESCAPLCTPGVDVYWSRDDKRFAVVWLAIWSVLCFFSSAFTVLTFLIDPSRFRYPERPIIFLSMCYCVYSVGYIIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVFSLLYTVPATCVIACYFYERLNMDYWKMLATQHKCKMNNQTKTPDCLMTTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQHVCSRGLKRKSRRKPASVVTSAGIYKKAQHPQKPHLGKYELPAQPSACV
Protein: Colipase (Q9CQC2)
Organism: Mus musculus (Mouse)
Function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Pancreatic triacylglycerol lipase
- Inactive pancreatic lipase-related protein 1
- Pancreatic lipase-related protein 2
- Bile salt-activated lipase
- Chymotrypsinogen B
- Carboxypeptidase A1
- Chymotrypsin-like elastase family member 3B
- Chymotrypsin-like elastase family member 2A
- Syncollin
- Zymogen granule membrane protein 16
Sequence:
MEKVLVLLLVSLLAVAYAAPGPRGLIINLEDGEICLNSMQCKSRCCQHDTILGIARCTHKAMENSECSPKTLYGIYYRCPCERGLTCEGDRSIIGAITNTNYGICLDSRRSKQ
Protein: Rifin (Q8I4N6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKIHYINILLFPLKLNILIYNQRNHKSTTHHTLKIPITRLLCECELYTPANYDNDPQMKEVMDNFNRQTQQRFHEYDERMVEKRMQCKDKCDKEIQKIILKDKLEKQMEQQLTTLETKITTDDIPTCLCEKSVADKMEKTCLRCAGVLGGGVMPGMGLIDGSLLGAISVLKPAAIIAAKDAALAEATALATQAGMREVVLKIEQFLKLFSEKEKIFDLKLIVNKSNFSCGSSLFQNAKELANKSCVAKPNGSYTSFCNSITYSRVEPFNGYAQAGITKYNETLPLQKALLEKAKVDAVNTTYAAYHTSIIASIVAVVVIVLIMVIIYLILRYRRKKKMKKKLQYIKLLEE
Protein: BZIP transcription factor (Fcr3), putative (Q4WIA4)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- very-long-chain enoyl-CoA reductase
Sequence:
MDYSFYSNPQSQQPFSVYDLHGLPTPDQNNPAPNGDDINDPFSSLVNYHSFHPSFRIQNPAAPSSFVPPPHSPPESFSKHSVSSNDFPNSHAEPGSVEGGDDQLQHRSSSEEKDNLTPAQSKRKAQNRAAQRAFRERKERHVRELEEKVSALEQESTTLAADNERLKRELAKFATENEVLRATTGQLASSQGRHLDSEPTITGPMKYTPTDFYTNLVPKGEPAPTHRVTVCEKTGERLLDAGATWDLIQGHELYKQGLVDIGDVSNRLKGMAQCNGQGPAFREGQVLQAIEASAAACRDELI
Protein: DUF3700 domain-containing protein (A0A384KZU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MLAIFQKAFAHPPEELNSPASHFSGKTPKLPGETLSDFLSHHQNNAFSMNFGDSAVLAYARQETSLRQRLFCGLDGIYCMFLGRLNNLCTLNRQYGLSGKNSNEAMFVIEAYRTLRDRGPYPADQVLRGLEGSFAFVVYDTQTSSVFSALSSDGGESLYWGISGDGSVVMSDDIQIIKQGCAKSFAPFPNGCMFHSETGLKSFDHPTNMMKAMPRIDSEGVLCGASFKVDACSKINSIPRRGSEANWALANSR
Protein: L-rhamnose-1-dehydrogenase (EC 1.1.1.173) (A3LZU7)
Organism: Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Function: NAD-dependent dehydrogenase that has high activity with L-rhamnose and L-lyxose, and shows only low activity with L-mannose. Has no activity with NADP. Catalyzes the first step in an alternative pathway for rhamnose utilization that does not involve phosphorylated intermediates.
Interaction partners:
- L-rhamnono-gamma-lactonase
Sequence:
MTGLLNGKVVAITGGVTGIGRAIAIEMARNGAKVVVNHLPSEEQAQLAKELKEEISDGENNVLTIPGDISLPETGRRIVELAVEKFGEINVFVSNAGVCGFREFLEITPETLFQTVNINLNGAFFAIQAAAQQMVKQGKGGSIIGISSISALVGGAHQTHYTPTKAGILSLMQSTACALGKYGIRCNAILPGTISTALNEEDLKDPEKRKYMEGRIPLGRVGDPKDIAGPAIFLASDMSNYVNGAQLLVDGGLFVNLQ