wanglab/gogpt-training-data huggingface dataset:
Protein: Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5) (Q9P267)
Organism: Homo sapiens (Human)
Function: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
Subcellular location: [Isoform 1]: Nucleus {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419}. Chromosome {ECO:0000269|PubMed:20700456}. Note=Associates with heterochromatin containing chromocentres in a DNA methylation-independent manner (PubMed:20700456). Does not localize to sites of DNA damage (PubMed:24634419). {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419}. Note=Does not associate with heterochromatin containing chromocentres (PubMed:20700456). Does not localize to sites of DNA damage (PubMed:24634419). {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419}.
Interaction partners:
- Putative Polycomb group protein ASXL2
- Forkhead box protein K1
- AOF1 protein
- Polycomb group protein ASXL1
- Ubiquitin carboxyl-terminal hydrolase BAP1
Sequence:
MNGGKECDGGDKEGGLPAIQVPVGWQRRVDQNGVLYVSPSGSLLSCLEQVKTYLLTDGTCKCGLECPLILPKVFNFDPGAAVKQRTAEDVKADEDVTKLCIHKRKIIAVATLHKSMEAPHPSLVLTSPGGGTNATPVVPSRAATPRSVRNKSHEGITNSVMPECKNPFKLMIGSSNAMGRLYVQELPGSQQQELHPVYPRQRLGSSEHGQKSPFRGSHGGLPSPASSGSQIYGDGSISPRTDPLGSPDVFTRSNPGFHGAPNSSPIHLNRTPLSPPSVMLHGSPVQSSCAMAGRTNIPLSPTLTTKSPVMKKPMCNFSTNMEIPRAMFHHKPPQGPPPPPPPSCALQKKPLTSEKDPLGILDPIPSKPVNQNPVIINPTSFHSNVHSQVPMMNVSMPPAVVPLPSNLPLPTVKPGHMNHGSHVQRVQHSASTSLSPSPVTSPVHMMGTGIGRIEASPQRSRSSSTSSDHGNFMMPPVGPQATSSGIKVPPRSPRSTIGSPRPSMPSSPSTKSDGHHQYKDIPNPLIAGISNVLNTPSSAAFPTASAGSSSVKSQPGLLGMPLNQILNQHNAASFPASSLLSAAAKAQLANQNKLAGNNSSSSSNSGAVAGSGNTEGHSTLNTMFPPTANMLLPTGEGQSGRAALRDKLMSQQKDALRKRKQPPTTVLSLLRQSQMDSSAVPKPGPDLLRKQGQGSFPISSMSQLLQSMSCQSSHLSSNSTPGCGASNTALPCSANQLHFTDPSMNSSVLQNIPLRGEAVHCHNANTNFVHSNSPVPNHHLAGLINQIQASGNCGMLSQSGMALGNSLHPNPPQSRISTSSTPVIPNSIVSSYNQTSSEAGGSGPSSSIAIAGTNHPAITKTTSVLQDGVIVTTAAGNPLQSQLPIGSDFPFVGQEHALHFPSNSTSNNHLPHPLNPSLLSSLPISLPVNQQHLLNQNLLNILQPSAGEGDMSSINNTLSNHQLTHLQSLLNNNQMFPPNQQQQQLLQGYQNLQAFQGQSTIPCPANNNPMACLFQNFQVRMQEDAALLNKRISTQPGLTALPENPNTTLPPFQDTPCELQPRIDPSLGQQVKDGLVVGGPGDASVDAIYKAVVDAASKGMQVVITTAVNSTTQISPIPALSAMSAFTASIGDPLNLSSAVSAVIHGRNMGGVDHDGRLRNSRGARLPKNLDHGKNVNEGDGFEYFKSASCHTSKKQWDGEQSPRGERNRWKYEEFLDHPGHIHSSPCHERPNNVSTLPFLPGEQHPILLPPRNCPGDKILEENFRYNNYKRTMMSFKERLENTVERCAHINGNRPRQSRGFGELLSTAKQDLVLEEQSPSSSNSLENSLVKDYIHYNGDFNAKSVNGCVPSPSDAKSISSEDDLRNPDSPSSNELIHYRPRTFNVGDLVWGQIKGLTSWPGKLVREDDVHNSCQQSPEEGKVEPEKLKTLTEGLEAYSRVRKRNRKSGKLNNHLEAAIHEAMSELDKMSGTVHQIPQGDRQMRPPKPKRRKISR
Protein: ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2) (P70170)
Organism: Mus musculus (Mouse)
Function: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- ATP-sensitive inward rectifier potassium channel 8
- ATP-sensitive inward rectifier potassium channel 11
- ATP-binding cassette sub-family C member 8
- ATP-sensitive inward rectifier potassium channel 1
- Syntaxin-1A
Sequence:
MSLSFCGNNISSYNIYYGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSHRASRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQLGWGVSDLRFCITGVMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNEKTNTTREMFPETLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRAGEGTLPFESCKKHTGVQSKPINRKQPGRYHLDSYEQARRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEEDNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINHPGKADQTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIVDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLVMTNK
Protein: LisH domain-containing protein ARMC9 (Armadillo repeat-containing protein 9) (Melanoma/melanocyte-specific tumor antigen KU-MEL-1) (NS21) (Q7Z3E5)
Organism: Homo sapiens (Human)
Function: Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length. Acts as a positive regulator of hedgehog (Hh)signaling (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28625504}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9D2I5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28625504}. Note=Localized to the proximal region in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (By similarity). Localizes to the daughter centriole of the primary cilium in RPE1 cells (PubMed:28625504). {ECO:0000250|UniProtKB:Q9D2I5, ECO:0000269|PubMed:28625504}.
Interaction partners:
Sequence:
MGDILAHESELLGLVKEYLDFAEFEDTLKTFSKECKIKGKPLCKTVGGSFRDSKSLTIQKDLVAAFDNGDQKVFFDLWEEHISSSIRDGDSFAQKLEFYLHIHFAIYLLKYSVGRPDKEELDEKISYFKTYLETKGAALSQTTEFLPFYALPFVPNPMVHPSFKELFQDSWTPELKLKLIKFLALISKASNTPKLLTIYKENGQSNKEILQQLHQQLVEAERRSVTYLKRYNKIQADYHNLIGVTAELVDSLEATVSGKMITPEYLQSVCVRLFSNQMRQSLAHSVDFTRPGTASTMLRASLAPVKLKDVPLLPSLDYEKLKKDLILGSDRLKAFLLQALRWRLTTSHPGEQRETVLQAYISNDLLDCYSHNQRSVLQLLHSTSDVVRQYMARLINAFASLAEGRLYLAQNTKVLQMLEGRLKEEDKDIITRENVLGALQKFSLRRPLQTAMIQDGLIFWLVDVLKDPDCLSDYTLEYSVALLMNLCLRSTGKNMCAKVAGLVLKVLSDLLGHENHEIQPYVNGALYSILSVPSIREEARAMGMEDILRCFIKEGNAEMIRQIEFIIKQLNSEELPDGVLESDDDEDEDDEEDHDIMEADLDKDELIQPQLGELSGEKLLTTEYLGIMTNTGKTRRKGLANVQWSGDEPLQRPVTPGGHRNGYPVVEDQHTPPQTAQHARNGHPQALPAAHEAVYREGKPSTPESCVSSSSAIIAKPGEWLPRGRQEEPRPAPTGTPRQPREAPQDPGNGVTTRECASAFTCKPRAPCTPEMLDWNPPKAKASVLAPLFSSCGPQQASRPGSTASSTRGLPSSQSHRK
Protein: ORF128 ankyrin repeat protein (Q6TVJ2)
Organism: Orf virus (strain Goat/Texas/SA00/2000) (OV-SA00) (Orf virus-San Angelo 2000)
Interaction partners:
Sequence:
MDFLGAALYDYVADAENVRVDEVRRLLAAGASVEYAGEFGKTALHQYMGRSGTDPAVVRALLDAGARVDLPETCCGCTPVHLCLMSANIDVEVLRMLVHEGRVEDCGRAELASAVLKEFVVNRAFDENVTERVMHVLVSAGADVNAASVVDRTPLHVCLTGMSTHPGTIAALLRFGADVNAVDLCGMSPLAVLVRSRAATAELVRMLLDGGADTHAVDSRLDSLLHQHFQSARPRPEVVHELIRHGCSPRARNRIGNTPLHEAAKHSSCKHSLVGPLLAAGASVDARNNAGRTPLHLAAASNPRACRRLIALGADVVARSYAGVTPLAQLVADNNSALVTAALNTQPEPRAVAESLRATTPVGETACSRLCVAYVVARAPSEVLGEPERALHAAFVAECLAEVAAIHAVRCGTPPVSLLEILVAARPPRSLLSRRARRLAESRTTVYRAPLRARIAAMRHRSRLVERALRALRDCVLPREVLERVLRCLSTQDLRASGLAE
Protein: Probable methyltransferase PMT7 (EC 2.1.1.-) (Q9LZA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- UPF0057 membrane protein At4g30650
Sequence:
MGGGYVLFGSARSGQMIMVALVLMVGSFYAGSIFGNNSPIYISQPSSSNSSSSSPSQSGPSNFANKIELTYRRTSVSIPESGVNVCPLKFNEYIPCHNVTYVQQLLPSLNLSRREELERHCPPLEQRLFCLVPPPKDYKIPIRWPTSRDYVWRSNVNHTHLAEVKGGQNWVHEQGQLWWFPGGGTHFKHGAPEYIQRLGNMTTNETGDLLSAGVEQVLDVGCGVASFAAYLLPLGIKTMSFAPKDGHENQIQFALERGIRAMISAIATKQMPYPAASFDMVHCSRCRVDWHENDGVLMKEVNRLLRPNGYFVYSAPPAYRKDKDFPVIWDKLVNLTSAMCWKLISRKVQTAIWVKEDDEACLRKNAELELITICGVEDVSKASWKVPLRDCVDISENRQQKPSSLTDRLSSYPTSLREKGISEDEFTLDTNFWREQVNQYWELMNVNKTEVRNVMDTNAFIGGFAAAMNSYPLWVMNVVPATMNDTLSGIYQRGLTGAYHDWCEPFSTYPRTYDLLHADHLFTHYKIYGEGCLLEDIMLEMDRIIRPQGFIIIRDEESIVSRVRDLAPKFLWEVEAHELQDKYKKTETVLFCRKKFWAIL
Protein: Small ribosomal subunit protein uS19y (40S ribosomal protein S15-3) (Q9FY65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein uS12z
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS1z
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS24y
Sequence:
MADPEVAAAGIVKKRTFKKFSFRGVDLDALLDMSTDDLVKLFPSRIRRRFSRGLTRKPMALIKKLRKAKIEAPAGEKPAAVRTHLRNMIIVPEMIGSVIGVYNGKTFNQVEIKPEMIGHYLAEFSISYKPVKHGRPGVGATNSSRFIPLK
Protein: Probable WRKY transcription factor 65 (WRKY DNA-binding protein 65) (Q9LP56)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223}.
Interaction partners:
Sequence:
MKRGLDMARSYNDHESSQETGPESPNSSTFNGMKALISSHSPKRSRRSVEKRVVNVPMKEMEGSRHKGDTTPPSDSWAWRKYGQKPIKGSPYPRGYYRCSSTKGCPARKQVERSRDDPTMILITYTSEHNHPWPLTSSTRNGPKPKPEPKPEPEPEVEPEAEEEDNKFMVLGRGIETTPSCVDEFAWFTEMETTSSTILESPIFSSEKKTAVSGADDVAVFFPMGEEDESLFADLGELPECSVVFRHRSSVVGSQVEIF
Protein: HPt domain-containing protein (Q9HYQ0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable two-component response regulator
- histidine kinase
- Sensory/regulatory protein RpfC
- histidine kinase
- STAS domain-containing protein
- histidine kinase
- GfdT protein
- FimX
Sequence:
MSAPHLDDRVLASLQEVMEDEYPVLLDTFVLDSEERLRSLHAALQAGDAQALRHTAHSFKGGSSNMGAVLLAGYCKELEESARRGELQRAPALIEQMEREFAIVRILFKQERQRYR
Protein: T. brucei spp.-specific protein (Q38ES7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKRNICWTSRVSLLFFFLCLFGVCLCCVELRPKRDEKCVIILSFYCSVSFCFVNAFLFFFLLTFLNFRFYFIKKNKKEEIISIFLSFSLFFLYPLFVQFHCPFNLFYPFFFLLLFLFPTCVMISYTLPIYNYFFFLLISLFFTFLLFFF
Protein: Peroxisomal membrane protein PEX13 (Peroxin-13) (D4A2Y9)
Organism: Rattus norvegicus (Rat)
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins (By similarity).
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:30414318}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisomal membrane protein PEX14
- Peroxisome assembly protein 12
- Peroxisomal targeting signal 1 receptor
- Peroxisome biogenesis factor 10
- Peroxisomal biogenesis factor 19
- Peroxisomal targeting signal 1 receptor.
- Peroxisomal targeting signal 2 receptor
- Peroxisomal biogenesis factor 3
- Peroxisomal ATPase PEX6
- Peroxisomal membrane protein PEX16
Sequence:
MASQPPPPPKPWETRRIPGAGPGPGPGPTFQSADLGPTLLTRPGQPTLTRVPPPILPRPSQQTGGNNVNTFRPAYSSFSSGYGAYGNAFYGSYSPYSYGYNGLGFNRLRVDDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQWMMGLRRGSENEDLWAESEGTVACLGAEDQANNSAKSWPIFLFFAVILGGPYLIWKLLSTHSDEVTDSTNWANGEDDHVVARAEYDFAAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGKRRGRKTVESSTMPKQQQSFTNPTSVKGVTTTNSLEEQEAAFESVFVETNKVAGTPDSTGKNGDKQDL
Protein: Co-chaperone protein DjlA (DnaJ-like protein DjlA) (P31680)
Organism: Escherichia coli (strain K12)
Function: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01153, ECO:0000269|PubMed:11106641, ECO:0000269|PubMed:8809778, ECO:0000269|PubMed:9364917}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_01153, ECO:0000269|PubMed:11106641, ECO:0000269|PubMed:8809778, ECO:0000269|PubMed:9364917}.
Interaction partners:
- Curved DNA-binding protein
- Chaperone protein DnaJ
- Chaperone protein DnaK
- Chaperone protein HscC
- Sensor histidine kinase RcsC
- Chaperone SurA
Sequence:
MQYWGKIIGVAVALLMGGGFWGVVLGLLIGHMFDKARSRKMAWFANQRERQALFFATTFEVMGHLTKSKGRVTEADIHIASQLMDRMNLHGASRTAAQNAFRVGKSDNYPLREKMRQFRSVCFGRFDLIRMFLEIQIQAAFADGSLHPNERAVLYVIAEELGISRAQFDQFLRMMQGGAQFGGGYQQQTGGGNWQQAQRGPTLEDACNVLGVKPTDDATTIKRAYRKLMSEHHPDKLVAKGLPPEMMEMAKQKAQEIQQAYELIKQQKGFK
Protein: Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) (Q14684)
Organism: Homo sapiens (Human)
Function: Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1. Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus. Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688, ECO:0000269|PubMed:26311876}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20926688}. Chromosome {ECO:0000269|PubMed:19710015}. Note=Predominantly located in the nucleolus with a small amount found in the nucleoplasm (PubMed:20926688). Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 (PubMed:20926688). Associates with heterochromatin and euchromatin (PubMed:19710015). {ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20926688}.; SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:26311876}. Note=(Microbial infection) Following infection by influenza A virus, partially translocates from the nucleolus to the nucleoplasm. {ECO:0000269|PubMed:26311876}.
Interaction partners:
- Probable rRNA-processing protein EBP2
- Ribosome biogenesis protein BOP1
- Ribosomal L1 domain-containing protein 1
- Ribosome biogenesis protein BRX1 homolog
- WD repeat-containing protein 74
- Protein MAK16 homolog
- Ribosome production factor 1
- Pescadillo homolog
- Ribosome biogenesis protein WDR12
- mRNA turnover protein 4 homolog
Sequence:
MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEELLKIWKGLFYCMWVQDEPLLQEELANTIAQLVHAVNNSAAQHLFIQTFWQTMNREWKGIDRLRLDKYYMLIRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKVGGKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFEAIVDQSPFVPEETMEEQKTKVGDGDLSAEEIPENEVSLRRAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTGPLLQFDYKAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDISADEDDQILSQGKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRRRKKKKKHHLQPENPGPGGAAPSLEQNRGREPEASGLKALKARVAEPGAEATSSTGEESGSEHPPAVPMHNKRKRPRKKSPRAHREMLESAVLPPEDMSQSGPSGSHPQGPRGSPTGGAQLLKRKRKLGVVPVNGSGLSTPAWPPLQQEGPPTGPAEGANSHTTLPQRRRLQKKKAGPGSLELCGLPSQKTASLKKRKKMRVMSNLVEHNGVLESEAGQPQALGSSGTCSSLKKQKLRAESDFVKFDTPFLPKPLFFRRAKSSTATHPPGPAVQLNKTPSSSKKVTFGLNRNMTAEFKKTDKSILVSPTGPSRVAFDPEQKPLHGVLKTPTSSPASSPLVAKKPLTTTPRRRPRAMDFF
Protein: Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) (Q5XKE0)
Organism: Mus musculus (Mouse)
Function: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity).
Interaction partners:
- Alpha-actinin-3
- Troponin T, fast skeletal muscle
- Tropomodulin-4
- Troponin C, skeletal muscle
- Troponin I, fast skeletal muscle
- Myosin-4
- Myosin light chain 1/3, skeletal muscle isoform
- Myosin light chain 3
- Myosin regulatory light chain 11
- Telethonin
Sequence:
MPEAKPAAKKASKGKDAPKEAPAKQTPEEPPKEAPPEDQSPTAEEPTGIFLKKPDSVSVETGKDAVILAKVNGKELPGKPTIKWFKGKWQELGSKSGARFIFKESHDSTSNVYTVELHIGKVVLGDRGDYRLEIKAKDVCDSCSFNVDVEAPRQDSSGQSLESFKRSGDGKSEDAGELDFSGLLKKREVVEEEKKKKKDDDDLGIPPEIWELLKGAKKSEYEKIAFQYGITDLRGMLKRLKKAKVEVKKSAAFTKKLDPAYQVDRGNKIKLVVEISDPDLPLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYEVAVQDEKCFTELFVKEPPVLIVTPLEDQQVFVGDRVEMSVEVSEEGAQVMWMKDGVEMTREDSYKARYRFKKDGKRHILIYSDVAQEDGGRYQVITNGGQCEAELIVEEKQLEVLQDIADLTVKAAEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKTSDNSIVVVAGNKLRLDVAITGEPPPTATWLRGDEVFTATEGRTHIEQRPDCSSFVIESAERSDEGRYTIKVTNPVGEDVASIFLRVVDVPDPPEAVRVTSVGEDWAILVWEPPKYDGGQPVTGYLMERKKKGSQRWMKINFEVFTDTTYESTKMIEGVLYEMRVFAVNAIGVSQPSMNTKPFMPIAPTSAPQHLTVEDVTDTTTTLKWRPPDRIGAGGIDGYLVEYCLEGSEEWVPANKEPVERCGFTVKDLPTGARILFRVVGVNIAGRSEPATLLQPVTIREIVEQPKIRLPRHLRQTYIRKVGEALNLVIPFQGKPRPQVVWTKGGAPLDTSRVNVRTSDFDTVFFVRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPAENVMVKEVWGTNALVEWQPPKDDGNSEITGYFVQKADKKTMEWFNVYEHNRHTSCTVSDLIVGNEYYFRIFSENICGLSDSPGVSKNTARILKTGITLKPLEYKEHDFRTAPKFLTPLMDRVVVAGYTAALNCAVRGHPKPKVVWMKNKMEIHEDPKFLITNYQGILTLNIRRPSPFDAGTYSCRAFNELGEALAECKLDVRVPQ
Protein: Aquaporin PIP2-1 (Plasma membrane intrinsic protein 2-1) (AtPIP2;1) (Plasma membrane intrinsic protein 2a) (PIP2a) (P43286)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Water channel required to facilitate the transport of water across cell membrane. Probably involved in root water uptake. Its function is impaired by Hg(2+).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10737809, ECO:0000269|PubMed:15060130, ECO:0000269|PubMed:18234664}; Multi-pass membrane protein {ECO:0000269|PubMed:10737809, ECO:0000269|PubMed:18234664}. Note=A fuzzy intracellular localization is induced by salt (NaCl) treatment.
Interaction partners:
- PAMP-induced secreted peptide 1
- Aquaporin SIP1-1
- Probable aquaporin SIP2-1
- Aquaporin PIP2-2
- Aquaporin PIP1-2
- Hydrophobic protein RCI2B
- Probable aquaporin SIP1-2
- Hydrophobic protein RCI2A
Sequence:
MAKDVEAVPGEGFQTRDYQDPPPAPFIDGAELKKWSFYRAVIAEFVATLLFLYITVLTVIGYKIQSDTDAGGVDCGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGANSLADGYSTGTGLAAEIIGTFVLVYTVFSATDPKRSARDSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSKPWDDHWIFWVGPFIGAAIAAFYHQFVLRASGSKSLGSFRSAANV
Protein: Basic leucine zipper 61 (AtbZIP61) (bZIP protein 61) (Q9M2K4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:17719007}.
Interaction partners:
- Basic leucine zipper 43
- AT-hook motif nuclear-localized protein 1
- Agamous-like MADS-box protein AGL104
- Basic leucine zipper 8
Sequence:
MAQLPPKIPTMTTPNWPDFSSQKLPSIAATAAAAATAGPQQQNPSWMDEFLDFSATRRGTHRRSISDSIAFLEPPSSGVGNHHFDRFDDEQFMSMFNDDVHNNNHNHHHHHSINGNVGPTRSSSNTSTPSDHNSLSDDDNNKEAPPSDHDHHMDNNVANQNNAAGNNYNESDEVQSQCKTEPQDGPSANQNSGGSSGNRIHDPKRVKRILANRQSAQRSRVRKLQYISELERSVTSLQTEVSVLSPRVAFLDHQRLLLNVDNSAIKQRIAALAQDKIFKDAHQEALKREIERLRQVYHQQSLKKMENNVSDQSPADIKPSVEKEQLLNV
Protein: Microtubule-associated protein 1 light chain 3 alpha (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (Microtubule-associated proteins 1A/1B light chain 3A) (MAP1A/MAP1B LC3 A) (MAP1A/MAP1B light chain 3 A) (Q9H492)
Organism: Homo sapiens (Human)
Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.
Subcellular location: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:12740394, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:22421968, ECO:0000269|PubMed:23459205}; Lipid-anchor {ECO:0000269|PubMed:15187094}. Endomembrane system {ECO:0000269|PubMed:12740394}; Lipid-anchor {ECO:0000269|PubMed:15187094}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91VR7}. Note=LC3-II binds to the autophagic membranes. {ECO:0000269|PubMed:15187094}.
Interaction partners:
- Sequestosome-1
- Ubiquitin-like modifier-activating enzyme ATG7
- Ubiquitin-like-conjugating enzyme ATG3
- Cysteine protease ATG4B
- Peptidyl-prolyl cis-trans isomerase FKBP8
- Serine/threonine-protein kinase ULK1
- Ubiquitin-like protein ATG12
- Autophagy protein 5
- Next to BRCA1 gene 1 protein
- Autophagy-related protein 13
Sequence:
MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFGF
Protein: Very long chain fatty acid elongase 6 (ELOVL6) (EC 2.3.1.199) (Elongation of very long chain fatty acids protein 6) (Neighbor of abl) (Very-long-chain 3-oxoacyl-CoA synthase) (Q9VV87)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs (By similarity). Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree (By similarity). May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:26214738}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q920L5}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- RH59310p)
- 3-oxoacyl-[acyl-carrier-protein] synthase
- Fatty acid synthase
Sequence:
MINMDISVTPNYSYIFDFENDFIHQRTRKWMLENWTWVFYYCGIYMLVIFGGQHFMQNRPRFQLRGPLIIWNTLLAMFSIMGAARTAPELIHVLRHYGLFHSVCVPSYIEQDRVCGFWTWLFVLSKLPELGDTIFIVLRKQPLIFLHWYHHITVLIYSWFSYTEYTSSARWFIVMNYCVHSVMYSYYALKAARFNPPRFISMIITSLQLAQMIIGCAINVWANGFLKTHGTSSCHISQRNINLSIAMYSSYFVLFARFFYKAYLAPGGHKSRRMAASLAAQNVVKQSSSPQQASESSKFIGAGEDQAAYLRKAKAQ