wanglab/gogpt-training-data huggingface dataset:
Protein: LDL receptor related protein 8 (A0A8I6ALZ7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046288}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00046288}.
Interaction partners:
Sequence:
MGRPERGALRPLALLLLLLLLLLQLQHLSTADPLPGGQGPVKECEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDCPKRTCTDSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPACPPREFRCGGGGTCIPERWVCDGQFDCEDRSDEAAELCGRAGQGTTATPAACAPTTQFTCRSGECIHLGWRCDGDRDCKDKSDEADCSAPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGCLQVAPIFQGNRRRPRGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGRSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPPSTSTTTLASAMTRTVPATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVNIPKAHSTSPSTLSPATSNHSQHYGNEGSQMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISSYDRPLWAEPCLGETRDLEDPAPAHKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP
Protein: Cold shock protein YdfK (P76154)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Serine recombinase PinQ
- Serine recombinase PinR
- Prophage tail fiber assembly protein homolog TfaQ
- H repeat-associated putative transposase YbfD
- Prophage tail fiber assembly protein homolog TfaR
Sequence:
MKSKDTLKWFPAQLPEVRIILGDAVVEVAKQGRPINTRTLLDYIEGNIKKKSWLDNKELLQTAISVLKDNQNLNGKM
Protein: Meiotic recombination protein REC114 (Q9CWH4)
Organism: Mus musculus (Mouse)
Function: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.
Subcellular location: Chromosome {ECO:0000269|PubMed:30569039}. Note=Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema and decreases at zygonema. {ECO:0000269|PubMed:30569039}.
Interaction partners:
- Ankyrin repeat domain-containing protein 31
- Interactor of HORMAD1 protein 1
- Meiosis inhibitor protein 1
- Meiotic recombination protein SPO11
- Meiosis-specific protein MEI4
- Type 2 DNA topoisomerase 6 subunit B-like
- HORMA domain-containing protein 1
- Transcription termination factor 2
- L-fucose kinase
- Serine/threonine-protein kinase Nek9
Sequence:
MSEAGNVASGLGLPGEVSQWSLKRYGRFMLLDNVGSPGPSSEAAAAGSPTWKVFESSEESGSLVLTIVVSGHFFISQGQTLLEGFSLIGSKNWLKIVRRMDCLLFGTTIKNKSRMFRVQFSGESKEEALERCCGCVQTLAQYVTVQEPDSTTQELQQSQGPREAGESQGKDPLQQGPSLTLEQHVCMAAGAGVLQERTSVTHRAQSILAPEKLTLAYEGSSWGTEELGPFLRLCLMDQNFPAFVEEVEKELKKITGLRN
Protein: Regulatory associated protein of MTOR, complex 1 (A0A8I6ANV2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MESEMLQSPLMGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKVAAINPNHPLAQMPLPPSMKNCIQLAACEAHELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRSPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILAVIVNSYTTGQEACLQGNLIAICLEQLSDPHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAERTDHSTTIDHNVAMMLAQLINDGSPMVRKELVVALSHLVVQYESNFCTVALQFMEEEKNYPLPSPAATEGGSLTPVRDSPCTPRLRSVSSYGNIRAVTTARNLNKSLQNLSLTEESGSSVAFSPGNLSTSSSASSTLGSPENEEYILSFETIDKMRRVSSYSALNSLIGVSFNSVYTQIWRVLLHLAADPYPDVSDLAMKVLNSIAYKATVNARPQRILDTSSLTQSAPASPTNKGMHIHQVGGSPPASSTSSCSLTNDVAKQTVSRDLPSSRPGTAGPTGAQYTPHSHQFPRTRKMFDKGPDQTTDDADDAAGHKSFICATMQTGFCDWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNTRVRKQAQQVIQKGITRLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKAYLQKHPEGHIVSVSVNGDVRFFDPRMPESVNVMQIVKGLTALDIHPQANLIACGSMNQFTAIYNGNGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKRVR
Protein: DNA-binding transcriptional regulator NtrC (Nitrogen regulation protein NR(I)) (Nitrogen regulator I) (NRI) (P0AFB8)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. Activates transcription of many genes and operons whose products minimize the slowing of growth under nitrogen-limiting conditions, including genes coding for glutamine synthetase (glnA), transporters, amino acid permeases and catabolic enzymes.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Sensory histidine kinase/phosphatase NtrB)
- RNA polymerase sigma-54 factor
- Nitrogen regulatory protein GlnK
- Glutamine synthetase
- Ammonium transporter AmtB
- Bifunctional uridylyltransferase/uridylyl-removing enzyme
- Nitrogen regulatory protein P-II 1
- RNA polymerase sigma factor RpoD
- Nitrate/nitrite response regulator protein NarL
- Xylose operon regulatory protein
Sequence:
MQRGIVWVVDDDSSIRWVLERALAGAGLTCTTFENGAEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAISHYQEQQQPRNVQLNGPTTDIIGEAPAMQDVFRIIGRLSRSSISVLINGESGTGKELVAHALHRHSPRAKAPFIALNMAAIPKDLIESELFGHEKGAFTGANTIRQGRFEQADGGTLFLDEIGDMPLDVQTRLLRVLADGQFYRVGGYAPVKVDVRIIAATHQNLEQRVQEGKFREDLFHRLNVIRVHLPPLRERREDIPRLARHFLQVAARELGVEAKLLHPETEAALTRLAWPGNVRQLENTCRWLTVMAAGQEVLIQDLPGELFESTVAESTSQMQPDSWATLLAQWADRALRSGHQNLLSEAQPELERTLLTTALRHTQGHKQEAARLLGWGRNTLTRKLKELGME
Protein: DNA repair protein RadA (Q8NMB3)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- Regulatory protein RecX
- Protein RecA
- DNA integrity scanning protein DisA
- DNA repair protein RecN
- Thiamine-monophosphate kinase
- Single-stranded DNA-specific exonuclease
- DNA polymerase I
- UvrABC system protein C
- Holliday junction branch migration complex subunit RuvB
- Adenine DNA glycosylase
Sequence:
MAKKVRSVHECSECGYSSPKWLGRCPECGSWGSMEERTVGESGGAARAAVSGAAPAGLTPTSPAVPIGKIVASQATSISTGIGELDRVLGNGIVPGSVVLMAGEPGVGKSTLLLEVASRWASMKEGDGTRTALYVTAEESAGQVRLRAERTAAVKDTLYLAAESNLDVVFGHVNQVKPSLLIVDSVQTMHAAGVEGVAGGVAQSRAVTAALTTLAKTSGIPILLVGHVTKDGNVAGPRVLEHLVDVVLNFEGDRHSSLRMLRGIKNRFGATDEVGCFEQQSDGIKEVPDPSGLFLSHRGSTPDGTAVTVAMDGVRPLLAEVQSLLVDAPSKNPRRVVTGLDANRVPMVLAVLSARAGRQTQGKDAYVATVGGMKVGEPATDLAVALATASALAKKPLPDKTVVLGEVGLAGEIRRVPNVDRRLAEAERLGYEKAVIPGGSGIKQTSLRVIEASTLAEALAAVSL
Protein: Uncharacterized protein YLR179C (Q06252)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL10m
- Large ribosomal subunit protein uL30m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein uL23m
- Small ribosomal subunit protein uS2m
Sequence:
MSSAIVAKLNKEDIIKDTVKDLAFEILGELSVSYVDSDDIKLGNPMPMEATQAAPTIKFTPFDKSQLSAEDKLALLMTDPDAPSRTEHKWSEVCHYIITDIPVEYGPGGDIAISGKGVVRNNYIGPGPPKNSGYHRYVFFLCKQPKGADSSTFTKVENIISWGYGTPGAGAYDYIKENNLQLVGANYYMVENTTVDFNYDM
Protein: Meiosis-inducing protein 1 (P21190)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor required for sporulation and for early sporulation-specific genes expression. Positive regulator of SME1/IME2 expression. Directly activates expression of SLZ1 during meiosis.
Subcellular location: Nucleus.
Interaction partners:
- Transcriptional regulatory protein UME6
- Serine/threonine-protein kinase RIM11/MSD1
- Zinc finger protein RME1
- Meiosis induction protein kinase IME2/SME1
- N
- Meiosis-specific transcription factor NDT80
- Tyrosine-protein phosphatase YVH1
- Sporulation-specific wall maturation protein
- Suppressor of mar1-1 protein
- Respiration factor 1
Sequence:
MQADMHGKLHAALEDGFFLFPFEQQQQPNIYYDTTTDQEDRPCFSFGSTISPRSWHFEKSDKIASSQLQNLVHTQPIHLINPQILFNEEFLNLENIDSQPISKETKTTKDCTMATGPERGKKSSESTRSSSLSSLFSNDESASTFHSSFNNHDNFQKSNRNGDDIDISDTIKYETNTNAQKDIKIFQENFEFNEFPYTQDFYPYTTNYTYSKPTNIHESINSKNTDSYSQYQDQFPPHTDNIHSFNNRHYSNHKSTNCNYYNNTSNNNNASDNVYEADPFIDEPQVPSYYYPLEIAFDVEKSPPPSLQKLNSKELEFLKKLNSKLSRYAAAYSFSSSNDQDYYDKVRFQEISYKFSKTYS
Protein: CD109 antigen (GPI-anchored alpha-2 macroglobulin-related protein) (CD antigen CD109) (Q8R422)
Organism: Mus musculus (Mouse)
Function: Modulates negatively TGFB1 signaling in keratinocytes.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
- CD9 antigen
Sequence:
MRSRRLLSAAHLLCLCAVALAAPGSRFLVTAPGIIRPGANVTIGVDLLENSPPQVLVKAQVFKIASNKSRSILEAEGVFHRGHFKTLVLPALPLSSADKIYELHINGQSENEIVFSNRTRLTFESKSISVLIQTDKAFYKPKQEVKFRVLTLCSDLKPYRTSVDIFIKDPKSNVIQQWFSQKGDLGVVSKTFQLSSNPIFGDWSIQVQVNDQQYYQSFQVLEYVLPKFEVTVQTPLYCSLKSKQLNGSVIAKYTYGKPVKGSLSLTFLPLSFWGKKKNITKSFEINGFANFSFDNYEMKKVMNLKPLTDVSEGSYENVDPSFPGPAEIIATVTESLTGISRMASTNVFFKQHDYIIEIFDYTTVLKPSLNFTATVKVSRSDGNQLTPEEIENDLVTVVTQRKNNHPESQRDQEMDYIQTVNYTIPQNGIIKIEFPVMSISGELQLKAYFLDGTSSVTVHSMFTSPSKTYIQLKTRDEYIKVGSPFDLMVSGNRQFKDLSYMVISKGQLVAAGKQSSRTFSLTPEASWAPKACIIAYYIAEDGEIINDILKIPVQLVFENKVKLFWSKPTVKPSDKVSLRISATQSDSLVGIVAVDKSVTLMENSNSITMETMVHELELYNTEYYLGMFMNSFAVFQECGLWVLTDATLIRDSIDEVYDTEEYSERFAEENEANLVDFEDASSVNNVHVRKNFPETWIWLDAYMGSKIYEEFEVTVPDSITSWVASAFVISEDLGFGLTTVPAELQAFQPFFLFLNLPYSVIRGEEFALEVSIVNYLKDTIKVVILIEESDSFDILMTSNDTNGTIYRKTVQVPRDNGVTLVFPIKPTHLGEIPITVTAASPTASDAVTQTIVVKPEGIEKSYSKSVLLDLTDSNVESKQQSMRFSFPPDTVIGSERVQITAIGDILGSSINGLSSLIRMPYGCGEQNMIYFAPNIYILDYLTKQKQLTVNLKEKALSYMRQGYQRELLYQREDGSFSAFGDIDSSGSTWLSAFVLRCFLEADYYIDIDQDVLHRTYTWLNAHKKFNGEFWEPGRVIHSELQGGTKSPVTLTAYIVTSVLGYKKYQPNIDVQDSIKFLEFEFSRGISDNYTLAIISYALSTVGSPKAEEALNLLMQRSEKEGDTQFWLSSGPALSGSWQPRSVDIEIAAYALLAHTLHHVSEGIPVMRWLIQQRNSLGGFVSTQDTVVALKALSEFSALVHKENTDIQLTVTGPGIPRSIHFRIDSQNLFLLHQEELHALDPITVNVSAHGSGFAICQLNVDYNVKGSGSSKRRRSTENQEVFDLDVIVNNEDDISHLNLNVCTSHLGSERTGMVLMEVNLLSGFSASSDSIPLSETLKKVEYDNGKLNLYLDSVNESQFCVNIPTVRDYKVSNIRDGSVSVMDYYEPRRQAVRSYNTQVKLSSCYLSPDTNCKSHTDGATDSLRRSSSLLVFCSVLLYFVQH
Protein: ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) (Q14161)
Organism: Homo sapiens (Human)
Function: GTPase-activating protein for ADP ribosylation factor family members, including ARF1.
Interaction partners:
- Paxillin
- Rho guanine nucleotide exchange factor 7
- Rho guanine nucleotide exchange factor 6
- Cell division control protein 42 homolog
- G protein-coupled receptor kinase 4
- ARF GTPase-activating protein GIT1
- Serine/threonine-protein kinase PAK 1
- G protein-coupled receptor kinase 6
- Proto-oncogene tyrosine-protein kinase Src
- G protein-coupled receptor kinase 5
Sequence:
MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMRLQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN
Protein: S-layer protein (Parasporal protein) (Q9ZES5)
Organism: Bacillus thuringiensis subsp. finitimus
Function: The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of bacteria.
Subcellular location: Secreted, cell wall, S-layer.
Interaction partners:
Sequence:
MAKTNSYKKVIAGTMTAAMVAGVVSPVAAAGKSFPDVPADHWGIDSINYLVEKGAVTGNDKGMFEPGKELTRAEAATMMAQILNLPIDKDAKPSFADSQGQWYTPFIAAVEKAGVIKGTGNGFEPNGKIDRVSMASLLVEAYKLDTKVNGTPATKFKDLETLNWGKEKANILVELGISVGTTADKWEPKKTVTKAEAAQFIAKTDKQFGTEVAKVESAKAVTTQKVEVKFSKAVEKLTKEDVKLANKANNDKVLVKDVKLSEDKKSATVELYSNLAAKQTYTVDVNKVGKVEVTVGSLEAKTIEMADQTVVADEPTALKYTVKDENGTEVVSPAGIEFVTPAAEKINAKGEITLAKGTSTTVKAVYKKDGKVVAESKEVKVSAEGTAVASISNWTVAAEKADFTSKDFKQNDKVYEGDNVSVQVELKDQFNNVVNNVKAEYESLNTEVAVVDKATGKVTVLSAGKAPVKVTVKDSKGKELVSKTVEIEAFAQKAMKEIKLEKTNVALSTKDVTDFKVKAPVLDQYGKEFAAPVEVKVLDKDGKELKEQKLVAKYENKELVLNAHGQEAGKYTVELTAKSGKKEVKSKLALELKAPGVFSKFDVRGLENELDKYVTEENKKNEMVVSVLPVDANGLVLREKEAATLKVTTTDKDGKVVDATSGQVAVNDAAGTITVGNEAKAGETYKVTVVADGKLITTHSFKVVDTAPAAKKLAVDFTSTSLNEVAQGSELKTALLNILSVDGVPATTAGATVTDVKFVSADTNVVSEETAKFGTKGSTSIFVKELTVKKGEQTQKVELDKPVRVDVSIKEVKEVK
Protein: NAD(+) hydrolase SARM1 (NADase SARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and TIR motif-containing protein 1) (Q6PDS3)
Organism: Mus musculus (Mouse)
Function: NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (By similarity). Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17724133}. Cell projection, axon {ECO:0000269|PubMed:22678360}. Cell projection, dendrite {ECO:0000269|PubMed:21555464}. Synapse {ECO:0000269|PubMed:22678360}. Mitochondrion {ECO:0000269|PubMed:17724133, ECO:0000269|PubMed:26423149}. Note=Associated with microtubules. {ECO:0000269|PubMed:17724133}.
Interaction partners:
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- Myeloid differentiation primary response protein MyD88
- TNF receptor-associated factor 6
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
- TIR domain-containing adapter molecule 2
- Toll-like receptor 4
- Ubiquitin conjugation factor E4 B
Sequence:
MVLTLLFSAYKLCRFFTMSGPRPGADRLTVPGPDRSGGASPWWAAGGRGSREVSPGVGTEVQGALERSLPELQQALSELKQASAARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALANCALHGGQTVQRCMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVEHSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQSLVLLLDSSRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTTSALAKRALRLLGEEVPRRILPCVASWKEAEVQTWLQQIGFSQYCENFREQQVDGDLLLRLTDEELQTDLGMKSSITRKRFFRELTELKTFASYATCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIRLGVHRTRILSAAREMLHSPLPCTGGKLSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVIAARNFVLVLSAGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQALPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRPSQDSSAGSDTSLEGATPMGLP
Protein: Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) (Q9UL18)
Organism: Homo sapiens (Human)
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:20616046}.
Interaction partners:
- Protein argonaute-2
- Trinucleotide repeat-containing gene 6A protein
- Endoribonuclease Dicer
- RISC-loading complex subunit TARBP2
- Probable ATP-dependent RNA helicase DDX6
- Trinucleotide repeat-containing gene 6B protein
- Protein argonaute-4
- Ribonuclease 3
- Trinucleotide repeat-containing gene 6C protein
- Helicase MOV-10
Sequence:
MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA
Protein: Integrin subunit alpha D (A0A8I5ZVY4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Interaction partners:
Sequence:
TTMPFPPQSFLTLCHGFNLDTENPMTFQENARGFGQSVIQLGETRVVVAAPQEVKAVNQTGALYQCDYSTNRCDPIPLQVPPEAVNMSLGLSLAATTVPPQLLACGPTVHQNCKENTYVNGLCYLFGSNLLRKPQQFPEALRGCPQQESDIAFLIDGSGSINSIDFQKMKEFVSTVMDQFQKSKTLFSLMQYSDEFRTHFTFNDFKRNPDPKSHVRPIRQLNGRTKTASGIRKVVRELFQKINGARDNAAKILVVITDGEKFGDPLNYEDVIPEAEEAGIIRYVIGVGNAFHKPQSRRELDTIASKPAGDHVFQVDNFEALNTIRNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSAAITSNGPLLGSVGSFDWAGGAFLYPSKDKATFINTTRIDSDMNDAYLGYASAVISRNRVQSLVLGAPRYQHIGLVVMFKQNFGAWEPHTDIKGSQIGSYFGASLCSVDMDADGNTNLILIGAPHHYEKTRGGQVSVCPLPRGRARWQCEAILHGDQGHPWGRFGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFHGASVASISTPHSQRIAGARFSPGLQYFGQSLSGGKDLTMDGLMDLAVGAQGRLLLIRAQPVLRLEATMEFSPKNLARSVFACQEEVVKNKDAGEVRVCLHVRKNTKDRLREGDIQSTVTYDLALDPGRSVVRAFFDETKNGILRRIRVFGLTQKCETLKLILPDCVDNSVSPIILRLNYTLVGEPLRSSRDLRPVLAMEAQRIFTAMFPFEKNCGNDTICQDDLSITVSSIRVNTLVVGDSRDFDVSVTLRNDGEDSYGTKVTCYYPSGLSYRKVSASQNQFSKKPWRVIAEPSSSEGQGVLKSTIWDINHPIFPLWGAESQFLEVDKNCFPFSENNVSRTDKTESQLELPVKYAIYMVVTRCCSTPPVPSGWTPPALSLCSFAALCCSSGFFFLAFLFQNCSVAVCKRIQCDIPSFNSKEIFNVTLQGNLLFDWYIETSHDHLLLVSTAEILFNDSAFALLPGQETFVKAQTETKVEPYKVHNPVPLIVGSSVGGLVLLALITAGLYKLGFFKRQYKDMMNEAAPQDGPPQ
Protein: Protein S100-A3 (Protein S-100E) (S100 calcium-binding protein A3) (P33764)
Organism: Homo sapiens (Human)
Function: Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18083705}.
Interaction partners:
- Protein S100-A16
- Protein S100-A2
- Hornerin
- Protein S100-A10
- Protein S100-A1
- Protein S100-A13
- Protein-arginine deiminase type-3
Sequence:
MARPLEQAVAAIVCTFQEYAGRCGDKYKLCQAELKELLQKELATWTPTEFRECDYNKFMSVLDTNKDCEVDFVEYVRSLACLCLYCHEYFKDCPSEPPCSQ
Protein: Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) (P04574)
Organism: Sus scrofa (Pig)
Function: Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.
Interaction partners:
- Calpain-1 catalytic subunit
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Calpastatin
- Calpain-6
- Calpain-5
- Calpain-2 catalytic subunit
- Calpain 8
- Calpain 14
- Calpain-7
- Calpain-13
Sequence:
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS
Protein: Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1) (Q9NQ92)
Organism: Homo sapiens (Human)
Function: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:18404153}.
Interaction partners:
- Protein arginine N-methyltransferase 5
- Methylosome protein WDR77
- Serine/threonine-protein kinase RIO1
- Histone H4
- U3 small nucleolar RNA-associated protein 6 homolog
- Methylosome subunit pICln
Sequence:
MDLQAAGAQAQGAAEPSRGPPLPSARGAPPSPEAGFATADHSSQERETEKAMDRLARGTQSIPNDSPARGEGTHSEEEGFAMDEEDSDGELNTWELSEGTNCPPKEQPGDLFNEDWDSELKADQGNPYDADDIQESISQELKPWVCCAPQGDMIYDPSWHHPPPLIPYYSKMVFETGQFDDAED
Protein: Flotillin-like protein 2 (D2XNQ9)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles (By similarity). Required for early symbiotic events and nodules formation.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Membrane, caveola {ECO:0000250}. Note=In puncta evenly distributed in the cell membrane of root hair cells and polarly localized in root epidermal cells. No changes of localization upon inoculation with bacteria. {ECO:0000269|PubMed:20018678}.
Interaction partners:
Sequence:
MKIYRVAKASEYLVITGIFIKDIKLKKKAWIFPGQSCTVLDLSPVNYTFEVQAMSAEKLPFVLPAVFTIGPRVDDQESLLKYAKLISPHDRHSNHVNELVQGIIEGETRVLAASMTMEEVFRGTKQFKQEVFDKVQLELNQFGLLIYNANVKQLVDVPGHEYFSYLGQKTQMEAKNQARVDVSEAKMKGEIGSKLREGQTLQNAAKIDAETKVIAMQRAGEGEKEGIKVRTEVKVFENQREAEVAQANSELAKKKAAWTKAAQVAEVEAKKAVALREAELQGEVERMNALTTTEKLKADLLSKASVQYETKVQEANWELYKKQKETEAILYEKKAEAEAQKASADATFYASKQAAEAELYAKKKEAEGIVTLGQAQGAYVSTLLNALGNDYTAVRDYLMINGDMFQEIAKINAEAIRGLEPKISIWTNGGDNSGGITDGAMGMKEVAGVYKMLPPLFKTVHEQTGMLPPAWMGALSEKSS