wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphoserine aminotransferase 2, chloroplastic (AtPSAT2) (EC 2.6.1.52) (Q9SHP0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the plastidial phosphorylated pathway of serine biosynthesis (PPSB). Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- D-3-phosphoglycerate dehydrogenase 1, chloroplastic
- D-3-phosphoglycerate dehydrogenase 2, chloroplastic
- Phosphoserine phosphatase, chloroplastic
- D-3-phosphoglycerate dehydrogenase 3, chloroplastic
- Threonine synthase 1, chloroplastic
- Cysteine synthase, mitochondrial
- Cysteine synthase, chloroplastic/chromoplastic
- Cysteine synthase 1
- Bifunctional L-3-cyanoalanine synthase/cysteine synthase D2
- cysteine synthase
Sequence:
MAASTNSFLIGNQTQIPSLKPKSISQSFIHFTKPNTINLTTRTKSVSIRCASASTTVGSEQRVINFAAGPAALPENVLLKAQSDLYNWRGSGMSVMEMSHRGKEFLSIIQKAESDLRQLLEIPSEYSVLFLQGGATTQFAALPLNLCKSDDSVDYIVTGSWGDKAFKEAKKYCNPKVIWSGKSEKYTKVPTFDGLEQSSDAKYLHICANETIHGVEFKDYPLVENPDGVLIADMSSNFCSKPVDVSKFGVIYAGAQKNVGPSGVTIVIIRKDLIGNARDITPVMLDYKIHDENSSLYNTPPCFGIYMCGLVFDDLLEQGGLKEVEKKNQRKAELLYNAIDESRGFFRCPVEKSVRSLMNVPFTLEKSELEAEFIKEAAKEKMVQLKGHRSVGGMRASIYNAMPLAGVEKLVAFMKDFQARHA
Protein: Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) (O42870)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Phenylalanine--tRNA ligase beta subunit
- Phenylalanine--tRNA ligase, mitochondrial
- tRNA
- Putative proline--tRNA ligase C19C7.06
- Probable asparagine--tRNA ligase, cytoplasmic
- 25S rRNA adenine-N
- Histidine--tRNA ligase, mitochondrial
Sequence:
MSKLEALQVFLLEKLNEKNEIPNTSHLEFDGKKLGPQEAQSAILSLAAKNMIEFSRHEIEIYNLTAEGENICANGSHEAKVYNEICASMSGLNIGELKKKLGNSAGIGQGRAFKLGWIKKDGDKLVKNTDSITDETPKVLSEIKEHGTISDSKTLTDLKKRKLVERNKIMYFSLRKGPNFSLQIEKLNTDLTAEMITSRSWESAKFKSYNFAAEGIPPAGGCLHPLMKVREEFRKFFFELGFEEMPTNNFVESGFWNFDALFVPQQHSARDAQDTFFLKVPASTDKLPDPEYVARVKATHENGGETKGIGYRAPFSLEETRKLVLRTHTTAVSANMLYKLAQNGFHPAKYFSIDRVFRNETVDATHLAEFHQVEGVICDRNITLGDLIGFLEVFFGKMNVKNLRFKPAYNPYTEPSLEVFSYHEKLGKWVEVGNSGMFRPEMLEPMGLPKDVRCLGFGLSLERPTMIKYGVADIRQLIGPKVNLDLIEASPAVRLDKEE
Protein: LYR motif-containing protein At3g19508 (Q1G3M2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKKVLRVYGGVMRLVRLLPADSRPYYAKYARENFVNYREVDQSETSLDELFQRAYNHSLWVLKKYSIDESAATKLKEICFE
Protein: BMP/retinoic acid-inducible neural-specific protein 2 (Q8K1M8)
Organism: Rattus norvegicus (Rat)
Function: Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Immunoglobulin superfamily containing leucine-rich repeat protein 2
Sequence:
MRWPCSSRFRGLWPEAAPWAVLLALGVPGWVLAVSATVAAVVPEQHVSSAGQAPLDWLLTDRGPFHRAQEYADFMERYRQGFTTRYRIYREFARWKVNNLALERKDFFSLPLPLAPEFVRNIRLLGRRPNLQQVTENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSRKSETLGGVPVVGGTGNSSAVSLETLHQLAASYFIDRESTLRRLHHIQIATGAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKVQLLGLQVLLPEHLRERFVAAALSYITCSSEGELVCRENDCWCKCSPTFPECNCPDADIQAMEDSLLQIQDSWATHNRQFEESEEFQTLLKRLPSDRFLNSTAISQYWTMDANLQHRYQQLGASLKVLLKKMHRIVRRLFNLCKRCHRQPRFRLPKERSLSFWWNRIQSLLYCGESTFPGTFLEQSHSCTCPYDQSSCQGPIPCALGEGPACAHCASDNTTRCGSCNPGYVLAQGLCRPEVAESLENFLGLETDLQDLELKYLLQKRDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSLQICLTKNSTLEPVMAIYVNPFGGSHSESWFMPVNEGSFPDWERTNVDAAAQCQNWTITLGNRWKTFFETVHVYLRSRIKSLDDSSNETIYYEPLEMTDPSKNLGYMKINTLQVFGYSLPFDPDAIRDLILQLDYPYTQGSQDSALLQLIELRDRVNQLSPPGKVRLDLFSCLLRHRLKLANNEVGRIQSSLRAFNSKLPNPVEYETGKLCS
Protein: Growth/differentiation factor 8 (GDF-8) (Myostatin) (D1LWV2)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU369049}.
Interaction partners:
Sequence:
MQKLAVYVYIYLFMQIAVDPVVLDGSSQPTENAEKDGLCNACTWRQNTKSSRIEAIKIQILSKLRLEQAPNISRDVIKQLLPKAPPLQELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLVQMEGKPKCCFFKFSSKIQYNKVVKAQLWIYLRQVQKPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKAFDETGRDLAVTFPGPGEDGLNPFLEVRVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKILAMVVDRCGCS
Protein: Exocrine gland secreted peptide 24 (Exocrine gland-secreting peptide 24) (A8R0V6)
Organism: Mus musculus (Mouse)
Interaction partners:
- AUMP
Sequence:
MASFPVMSFLISLLLPSMLTEGMVLKQTQKESTISADHVILLISCQHTWEQTPWGLHSCQFDFRVDRG
Protein: Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (P48750)
Organism: Rattus norvegicus (Rat)
Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Subcellular location: Secreted.
Interaction partners:
- Colony stimulating factor 2 receptor subunit alpha
- Colony stimulating factor 2 receptor subunit beta
- Interleukin-2
- Interleukin-1 alpha
- Interleukin-1 beta
- Eotaxin
- Granulocyte colony-stimulating factor
- Interferon gamma
- Interleukin-3
- Interleukin-5
Sequence:
MWLQNLLFLGIVVYSFSAPTRSPNPVTRPWKHVDAIKEALSLLNDMRALENEKNEDVDIISNEFSIQRPTCVQTRLKLYKQGLRGNLTKLNGALTMIASHYQTNCPPTPETDCEIEVTTFEDFIKNLKGFLFDIPFDCWKPVQK
Protein: Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Q6PBW9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Ribose 5-phosphate isomerase A
- transketolase
- Transketolase
- 6-phosphogluconate dehydrogenase, decarboxylating
- Transaldolase
- RNA-binding motif protein 45
- 2-oxoisovalerate dehydrogenase subunit alpha
- Branched chain keto acid dehydrogenase E1 subunit beta.
- Pyruvate dehydrogenase E1 component subunit beta
- GDH/6PGL endoplasmic bifunctional protein)
Sequence:
MAYTAKIGPSILSSDLSQLGRECERMMECGADYLHLDVMDGHFVPNITFGHPMVECLRSCIGPDPFFDMHMMVSRPEQWVKPMAAAGANQYTFHLEATSNPGNLIKEIRESGMKVGLAIKPGTTVEELAPWAGQIDMALVMTVEPGFGGQKFMEDMMPKVSWLRGQFPSLDIEVDGGVGPDSIHRCAEAGANMIVSGSAVVSSDDPRSVIALLKNVVMEAIQKRSLDR
Protein: ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8 protein) (B1WBX3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLLTLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSSGDNTLHHCHVCSLLRRAARHA
Protein: Abnormal cell migration protein 10 (P34400)
Organism: Caenorhabditis elegans
Function: Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt-1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration.
Subcellular location: Perikaryon {ECO:0000269|PubMed:18499456}. Note=Enriched at the ventral edge of HSN cell bodies. This asymmetric distribution is regulated by ced-10/rac1. {ECO:0000269|PubMed:18499456}.
Interaction partners:
- UNC-34
- SH3 domain-containing protein
- Myosin regulatory light chain
- Ras-related protein ced-10
- Ras-related protein Rap-1
- Netrin unc-6
- Netrin receptor unc-40
- FERM domain-containing protein
- E3 ubiquitin-protein ligase TRIM9
- Actin-binding lim zn-finger protein limatin involved in axon guidance
Sequence:
MDSCEEECDLEVDSDEEDQLFGEKCISLLSSLLPLSSSTLLSNAINLELDEVERPPPLLNVLEEQQFPKVCANIEEENELEADTEEDIAETADDEESKDPVEKTENFEPSVTMDTYDFPDPYPVQIRARPQVPPKPPIDTVRYSMNNIKESADWQLDELLEELEALETQLNSSNGGDQLLLGVSGIPASSSRENVKSISTLPPPPPALSYHQTPQQPQLLHHHNNHLGYQNGIHQITSINSAASSCSSPDGDSAFGDSSSTESSNNRCRNSAFSSNDSCRDSLNTPSPTQVSPRNGELNAEEAKAQKIRQALEKMKEAKVTKIFVKFFVEDGEALQLLIDERWTVADTLKQLAEKNHIALMEDHCIVEEYPELYIKRVYEDHEKVVENIQMWVQDSPNKLYFMRRPDKYAFISRPELYLLTPKTSDHMEIPSGDQWTIDVKQKFVSEYFHREPVVPPEMEGFLYLKSDGRKSWKKHYFVLRPSGLYYAPKSKKPTTKDLTCLMNLHSNQVYTGIGWEKKYKSPTPWCISIKLTALQMKRSQFIKYICAEDEMTFKKWLVALRIAKNGAELLENYERACQIRRETLGPASSMSAASSSTAISEVPHSLSHHQRTPSVASSIQLSSHMMNNPTHPLSVNVRNQSPASFSVNSCQQSHPSRTSAKLEIQYDEQPTGTIKRAPLDVLRRVSRASTSSPTIPQEESDSDEEFPAPPPVASVMRMPPPVTPPKPCTPLTSKKAPPPPPKRSDTTKLQSASPMAPAKNDLEAALARRREKMATMEC
Protein: SUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation) (Q8NDZ2)
Organism: Homo sapiens (Human)
Function: Inhibits the protease activity of CAPN3.
Subcellular location: Nucleus, PML body {ECO:0000269|PubMed:36373674}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:23707407}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:23707407}.
Interaction partners:
Sequence:
MAPASASGEDLRKLPTMAEVNGEQDFIDLTRETRPRTKDRSGLYVIDLTRAEGENRPIATLDLTLEPVTPSQKEPTSLQTCASLSGKAVMEGHVDRSSQPTARRIINSDPVDLDLVEENTFVGPPPATSISGGSVYPTEPNCSSATFTGNLSFLASLQLSSDVSSLSPTSNNSRSSSSSSNQKAPLPCPQQDVSRPPQALPCPLRPLPCPPRASPCPPRASSCPPRALSCPSQTMQCQLPALTHPPQEVPCPRQNIPGPPQDSLGLPQDVPGLPQSILHPQDVAYLQDMPRSPGDVPQSPSDVSPSPDAPQSPGGMPHLPGDVLHSPGDMPHSSGDVTHSPRDIPHLPGDRPDFTQNDVQNRDMPMDISALSSPSCSPSPQSETPLEKVPWLSVMETPARKEISLSEPAKPGSAHVQSRTPQGGLYNRPCLHRLKYFLRPPVHHLFFQTLIPDKDTRENKGQKLEPIPHRRLRMVTNTIEENFPLGTVQFLMDFVSPQHYPPREIVAHIIQKILLSGSETVDVLKEAYMLLMKIQQLHPANAKTVEWDWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDDFQQTLRRQRQHLQQSIANMVLSCDKQPHNVRDVIKWLVKAVTEDGLTQPPNGNQTSSGTGILKASSSHPSSQPNLTKNTNQLIVCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIPERSQREMFFTTMESHLLRCKVLEIIFLHSCETPTRLPLSLAQALYFLNNSTSLLKCQSDKSQWQTWDELVEHLQFLLSSYQHVLREHLRSSVIDRKDLIIKRIKPKPQQGDDITVVDVEKQIEAFRSRLIQMLGEPLVPQLQDKVHLLKLLLFYAADLNPDAEPFQKGWSGS
Protein: Dehydrogenase/reductase (SDR family) member 3 L homeolog precursor (Dehydrogenase/reductase 3) (MGC80882 protein) (Q6GNT6)
Organism: Xenopus laevis (African clawed frog)
Interaction partners:
Sequence:
MDMSALGRLLLLPVQILFSILKVAANLLMPNKLRDLSGDTVLITGGGRGIGRHLAREFAKQKAKKIILWGRTERCLKETAEEIKQMGTDCSYFVCDVGNREEVYQQAKAVREKVGDVTILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCINSVLALSAIPGAIDYCTSKSSSFAFMESLTLGLLDCPGVNATTVLPYHTSTEMFQGMRVRFPSLFPSLKPETVATKTVEAVQKNKAFLLLPWTMHALVILKSILPQSALEEIHRFSGAYTCMNTFKGRT
Protein: Heat shock factor 2-binding protein (Q9D4G2)
Organism: Mus musculus (Mouse)
Function: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. Required for proper recombinase recruitment in female meiosis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23707421, ECO:0000269|PubMed:32845237}. Chromosome {ECO:0000269|PubMed:30760716, ECO:0000269|PubMed:31242413, ECO:0000269|PubMed:32345962, ECO:0000269|PubMed:32463460, ECO:0000269|PubMed:32845237}. Note=Localizes on double-strand breaks (DSBs) in mitotic and meiotic chromosomes. {ECO:0000269|PubMed:30760716, ECO:0000269|PubMed:31242413, ECO:0000269|PubMed:32345962, ECO:0000269|PubMed:32463460, ECO:0000269|PubMed:32845237}.
Interaction partners:
- Breast cancer type 2 susceptibility protein homolog
- Spermatogenesis-associated protein 22
- Break repair meiotic recombinase recruitment factor 1
- Meiosis-specific with OB domain-containing protein
Sequence:
MAATVGDGSGTEEACRNMESKEEFVKVRKKDLERLTTEVMQIRDFLPRILNGELLESFQKLKMVEKNLERKEQELEQLIMDREHFKARLETAQADSGREKKEKLALRQQLNEAKQQLLQQAEYCTQMGAVTCTLLWGVSSSEEVVKTILGGDKALKFFNITGQTMESFVKSLDGDVKEVDSDENQFVFALAGIVTNVAAIACGREFLVNSSRVLLDTMLQLLGDLKPGQCTKLKVLMLMSLYNVSINSKGLKYITESPGFIPLLWWLLSDPDAEVCLHTLRLIQSVVLEPDVFSKVASELQSSLPLQRILAMSKSRNSHLQSAAQELLEDLRALDCNV
Protein: Ig lambda chain V-1 region (P04210)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MAWAPLLLAVLAHTSGSLVQAALTQPSSVSANPGETVKITCSGDRSYYGWYQQKAPGSAPVTLIYDNTNRPSNIPSRFSGSKSGSTATLTITGVQADDEAVYYCGSADSSSTA
Protein: Zinc finger protein 711 (Vitelline envelope protein) (A7Y7X5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes, leading to activate their expression (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19117036}.
Interaction partners:
- Lysine-specific demethylase phf2
- Histone lysine demethylase PHF8
- Lysine-specific demethylase 5D
- PHD finger protein 13
- Cysteine and glycine-rich protein 1b.
- SH3 domain-binding glutamic acid-rich-like protein
Sequence:
MDQGGGILELHKDLKMPHTMIMPDFGMSGIAHLDGEHIVVSVPEAVMVSDVVTDEEGIMLETALEAEVVEEPDICQEDVITTEGVIMSESILGAEVAIQEALSGTADLIEETVPDQVFVAELMSPHIQSPLDHNLVSAEVMVTDADTVIDSHDTLQSDVTIKADDDVEDVKSTSEDYLMISLDEVGGKLDIEDTSLKISADVGQDDDGSKEDEFSSEVIKVYIFKADGDEDVEIGSTEVVEESDFPGRHTVMESVGSGRLPREKMVYMAVKDANQEDDLNCSEMTDQVYMEVIVGEEEAPAITEAQMEDSPVNKTIVPAAWATAYGSSLESKNGAATPYLQITDSISTSRALKQKIKKRRRGETRQCQTAVIIGPDGQPLTVYPCHICGKKFKSRGFLKRHMKNHPDHMFKKKYQCTDCEFTTNKKVSFHNHLESHKLIIKNEKIPEYTEYTRRYHEASPLSSNKLILRDKEPKLHKCKYCEYETAEQGLLNRHLLAVHSKNFAHVCVECAKGFRHPSELKKHMRTHTGEKPFHCQHCEFSCADQSNLKTHIKSKHGTDLPFKCGHCPQAFADDKELQRHAEIFQGHKTHQCPHCEHKSTNSSDLKRHIISVHTKDFPHKCDVCEKGFHRPSELKKHSETHKGNKVHQCRHCDFKTLDPFTLSRHILSVHTKDLPFKCKRCKRGFRHQNELKKHMKTHSGRKVYQCQYCEYNTTDASGFKRHVISIHTKDYPHRCDYCKKGFRRPSEKNQHIMRHHKETLL
Protein: PI-3 kinase (Phosphatidylinositol 3-kinase 92E, isoform A (EC 2.7.1.137, EC 2.7.1.153, EC 2.7.1.154)) (Phosphatidylinositol 3-kinase 92E, isoform B) (Phosphatidylinositol 3-kinase 92E, isoform C) (Phosphoinositide 3-kinase, Dp110) (SD05105p) (Uncharacterized protein Pi3K92E) (P91634)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Pi3K21B, isoform B
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Insulin-like receptor
- non-specific serine/threonine protein kinase
- Insulin receptor substrate 1
- RAC serine/threonine-protein kinase
- Autophagy-related 14
- Ras-like protein 1
- Serine/threonine-protein kinase mTor
- Beclin-1-like protein
Sequence:
MNMMDNRALAYVAHQPKYETPPEEAEPPCMRFSVNLWKNEMLNWVDLICLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSKNNKQ
Protein: Nucleocapsid VP1 (A0A1W6I186)
Organism: Sulfolobus polyhedral virus 1 (SPV1)
Function: Completely wraps the viral circular dsDNA genome to form a nucleoprotein filament. These interactions between the viral genome and the nucleocapsid proteins probably maintain the DNA in A-form (Probable). This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).
Subcellular location: Virion {ECO:0000269|PubMed:31636205}.
Interaction partners:
Sequence:
MATLTDVRNALQNAWTDDMKKAVKNAYRNAEKRASQGGNYAKCLEQASMQGTPYSLAAKKCAIENNLASTLSGLWGTS
Protein: Adenylosuccinate lyase (D3ZW08)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Bifunctional purine biosynthesis protein ATIC
- Trifunctional purine biosynthetic protein adenosine-3
- Adenylosuccinate synthetase isozyme 2
- Adenylate kinase 9
- Adenylosuccinate synthetase isozyme 1
- Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
- Amidophosphoribosyltransferase
- Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
- Adenine phosphoribosyltransferase
- Adenosine kinase
Sequence:
MAASGDPACAESYRSPLAARYASHEMCFLFSDRYKFQTWRQLWLWLAEAEQTLGLPITDEQIQEMRSNLSNIDFQMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNAFDLLLPKLARVISRLADFAKERADLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDELRFRGVKGTTGTQASFLQLFEGDHQKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMSLTMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILTTLQNVSEGLVLYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAAAVVKQEGGDNDLIERIRADAYFSPIHSQLEQLLDPSSFTGRAPQQVHRFLEEEVYPLLKPYGSVMAVKAELCL
Protein: Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein) (O60220)
Organism: Homo sapiens (Human)
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11489896}; Peripheral membrane protein {ECO:0000269|PubMed:11489896}; Intermembrane side {ECO:0000269|PubMed:11489896}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim13
- Mitochondrial import inner membrane translocase subunit Tim10
- Mitochondrial import inner membrane translocase subunit Tim9
- Mitochondrial import inner membrane translocase subunit Tim10 B
- Mitochondrial intermembrane space import and assembly protein 40
- Mitochondrial import inner membrane translocase subunit Tim23
- Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial
- Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim22
- Mitochondrial import receptor subunit TOM40 homolog
Sequence:
MDSSSSSSAAGLGAVDPQLQHFIEVETQKQRFQQLVHQMTELCWEKCMDKPGPKLDSRAEACFVNCVERFIDTSQFILNRLEQTQKSKPVFSESLSD
Protein: Neuropilin-1 (A5 protein) (CD antigen CD304) (P97333)
Organism: Mus musculus (Mouse)
Function: Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (By similarity). Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity).
Subcellular location: Mitochondrion membrane {ECO:0000250|UniProtKB:O14786}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O14786}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O14786}.
Interaction partners:
- Plexin-A3
- Semaphorin-3C
- Vascular endothelial growth factor receptor 2
- Semaphorin-3A
- Plexin-A4
- Semaphorin-3B
- Plexin-A1
- Plexin-A2
- Semaphorin-3D
- Semaphorin-3F
Sequence:
MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGMFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGVLSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYKEWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWISLKEGNKAIIFQGNTNPTDVVLGVFSKPLITRFVRIKPVSWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQADRNWMPENIRLVTSRTGWALPPSPHPYTNEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKTIMDDSKRKAKSFEGNNNYDTPELRTFSPLSTRFIRIYPERATHSGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPTDLDKKNTEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA
Protein: 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YbjI (EC 3.1.3.104) (P75809)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the dephosphorylation of 5-amino-6-(5-phospho-D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway. Is also able to dephosphorylate flavin mononucleotide (FMN), erythrose 4-phosphate and other phosphoric acid esters.
Interaction partners:
- 5-amino-6-
- Inner membrane protein YbjJ
- 6,7-dimethyl-8-ribityllumazine synthase
- Riboflavin biosynthesis protein RibD
- Bifunctional riboflavin kinase/FMN adenylyltransferase
- Class B acid phosphatase
- FMN reductase
- NAD
- Riboflavin synthase
- Phytase AppA
Sequence:
MSIKLIAVDMDGTFLSDQKTYNRERFMAQYQQMKAQGIRFVVASGNQYYQLISFFPEIANEIAFVAENGGWVVSEGKDVFNGELSKDAFATVVEHLLTRPEVEIIACGKNSAYTLKKYDDAMKTVAEMYYHRLEYVDNFDNLEDIFFKFGLNLSDELIPQVQKALHEAIGDIMVSVHTGNGSIDLIIPGVHKANGLRQLQKLWGIDDSEVVVFGDGGNDIEMLRQAGFSFAMENAGSAVVAAAKYRAGSNNREGVLDVIDKVLKHEAPFDQ
Protein: Methylenetetrahydrofolate reductase 2 (EC 1.5.1.53) (O74927)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Major methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine. Performs 15 to 20 percent of the total methylenetetrahydrofolate reductase activity of the cells.
Interaction partners:
- Methylenetetrahydrofolate reductase 1
- Serine hydroxymethyltransferase, mitochondrial
- Methylenetetrahydrofolate dehydrogenase [NAD
- C-1-tetrahydrofolate synthase, cytoplasmic
- Probable serine hydroxymethyltransferase, cytosolic
- Probable thymidylate synthase
- Probable aminomethyltransferase, mitochondrial
- C-1-tetrahydrofolate synthase, mitochondrial
- Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Uncharacterized protein C57A7.07c
Sequence:
MKIVDLIDKIPNGNAFYSFEYFPPKTTVGLENLSSRITRMSRNMMPLFSSVTWGTAGSTAEVSIYLAKMLEQHHKIPACLHLTCTNVDKAIIDKALETAKEYGIRNILALRGDPPLNSDHWEGKVSEFEHAVDLVRYIREKYGDYFCIGVAAYPEGHVDSNVPELSKDPLRDIPFLIEKVEAGADFIITQIFYEPEAFIKFENFVRNHSSNALRNIPIIPAIMPIQSYGSLKRMTRLCGCSVPSSLMQRLNAAKPDDEAIKNIGVEHIVDMIKKIMDNVQGRVHGFHFCTLNLERSVALILKNSGLLTKRWKQVESEMEDEKLLRTTRKRLSLDEPAELHNQVVVPSQQPVADKSSNLFVTSKQSSVSGHKDNLTEEAPFSVSEGSGVLGRQANWDDFTNGRFGDPRSPAYGEIDGYGPTLHFPPSEALKLWGYPVDESDITSLFQKHIMSDISAIPWIDEPVEVETKTIAKYLLKLNGNSWWTVGSQPAVNGAPSADPVFGWGPKGGRVFQKAFVECFVNGKDLKDFITKWHDNPQVTYYAGNNKSEFLTNAPKDGASAVTWGVYPGREIIQSTIIAEVSFKAWLSESFQVWGEWANLYSKNTPSRKLLENCINDRWLVTVIHHDFMDKNGLWKVLEIDF