wanglab/gogpt-training-data huggingface dataset:
Protein: Actin-regulating kinase 1 (EC 2.7.11.1) (P53974)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in regulation of actin cytoskeleton organization and endocytosis.
Subcellular location: Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:10087264, ECO:0000269|PubMed:14562095}. Note=Cortical actin patches.
Interaction partners:
- Actin-binding protein
- Actin cytoskeleton-regulatory complex protein PAN1
- Protein SLA2
- Actin cytoskeleton-regulatory complex protein SLA1
- Actin-regulating kinase PRK1
- Clathrin coat assembly protein AP180A
- Protein SCD5
- Epsin-1
- Proline-rich protein LAS17
- Actin cytoskeleton-regulatory complex protein END3
Sequence:
MNQPQIGTYNVGTQLTVGSHQVEIIKYLTSGGFAQVYSALINPPDPHSNSSVACLKRVIVPDKPSLNTLRAEVDAMRLLKNNRYVVSYIDSHAAKAMLHNGSYEVFVLMEYCERGGLIDFMNTRLQNRLHEFEILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISANNEYKLCDFGSVCGIIRPPRNSQELSYVQQDILKNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPFEKGGDLAILSGKFEFPLYPNYSEQLKGLIRDILVQDPRHRPNVYQLLKRISIMQNVPCPINDIQVVQAPSSHLNLTELHQLSATQNILSLNSPTTMENTMPNATFQISMADNTTTAQMHPNRKPSQIAYDASFSNSAKGSQPLFDKSQNMYHALDPPLVEPLASSVSNNDNELKANSATKLKQAIVSEAHTFRQNNSIDFPLQNIIPQYEDSSSSSDESYSGDVDELKKTRSLGSYSTRGNIKKNQSVKESLTSSSLPGTSFTPTSTKVNLKHENSPFKSTFVNTIDNSKDDLNKPSYEDLDVSKQNLKNSIQQRMIDKLNSSEESFNARKMSKVKLHEKGEIDKPTMLKSSGPISKDKKTKPTPPPKPSHLKPKPPPKPLLLAGRKLSLDK
Protein: DNA repair protein RAD51 homolog (C8VSQ3)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364139}.
Interaction partners:
- DNA repair and recombination protein radC
- 3'-5' exonuclease/helicase
- DNA 3'-5' helicase
- Replication protein A subunit
- DNA repair protein
- 5'-3' exonuclease and flap-endonuclease
- Crossover junction endonuclease mus81
- Myosin-binding domain-containing protein
- Postreplication repair E3 ubiquitin-protein ligase rad18
- Double-strand break repair protein
Sequence:
MTADMETQNEFDDSGLPGPGAPTPLSSLEGMAGLTSRDIKLFVDAGYHTVESIAYTPKRLLEQIKGISEQKATKILVEAAKLVPMGFTTATEMHARRSELISITTGSKQLDTLLGGGIETGSITEIFGEFRTGKSQICHTLAVTCQLPFDMGGGEGKCLYIDTEGTFRPVRLLAVAQRYGLVGEEVLDNVAYARAYNSDHQLQLLNQASQMMCETRFSLLVVDSATSLYRTDFNGRGELSTRQTHLAKFMRTLQRLADEFGIAVVITNQVVAQVDGGPSAMFNPDPKKPIGGNIIAHASTTRLSLKKGRGETRVCKIYDSPCLPESDCLFAINEDGIGDPSPKDLEND
Protein: Methionine import ATP-binding protein MetN (EC 7.4.2.11) (P30750)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. It has also been shown to be involved in formyl-L-methionine transport.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01719, ECO:0000305}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01719, ECO:0000305}.
Interaction partners:
- D-methionine-binding lipoprotein MetQ
- D-methionine transport system permease protein MetI
- Lipoprotein 28
- Glutathione/L-cysteine transport system ATP-binding/permease protein CydD
- Vitamin B12 import system permease protein BtuC
- Vitamin B12 import ATP-binding protein BtuD
- ATP-dependent lipid A-core flippase
- Putrescine transport ATP-binding protein PotG
- sn-glycerol-3-phosphate transport system permease protein UgpA
- Maltose/maltodextrin import ATP-binding protein MalK
Sequence:
MIKLSNITKVFHQGTRTIQALNNVSLHVPAGQIYGVIGASGAGKSTLIRCVNLLERPTEGSVLVDGQELTTLSESELTKARRQIGMIFQHFNLLSSRTVFGNVALPLELDNTPKDEVKRRVTELLSLVGLGDKHDSYPSNLSGGQKQRVAIARALASNPKVLLCDEATSALDPATTRSILELLKDINRRLGLTILLITHEMDVVKRICDCVAVISNGELIEQDTVSEVFSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEVLGYV
Protein: Nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1) (EC 2.7.7.18) (Q7KS06)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIVKISWPKNNITSECFRRFGSFKRRSKSKKMSAFIEETKSLLPRIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHINSGGGGGDDGENTHLPGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNFKSRDAPAPTECDS
Protein: Farnesyl-diphosphate farnesyltransferase 1 (E9PJG4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRM
Protein: Small ribosomal subunit protein bS18 (30S ribosomal protein S18) (P0A7T7)
Organism: Escherichia coli (strain K12)
Function: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Interaction partners:
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein bL28
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein bL17
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS4
Sequence:
MARYFRRRKFCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ
Protein: Ethylene receptor (Q41341)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Green ripe
- Ethylene receptor
- Green ripe-like 1
- 1-aminocyclopropane-1-carboxylate synthase 2
- Green ripe-like 2
Sequence:
MESCDCIEALLPTGDLLVKYQYLSDFFIAVAYFSIPLELIYFVHKSACFPYRWVLMQFGAFIVLCGATHFISLWTFFMHSKTVAVVMTISKMLTAAVSCITALMLVHIIPDLLSVKTRELFLKTRAEELDKEMGLIIRQEETGRHVRMLTHEIRSTLDRHTILKTTLVELGRTLDLAECALWMPCQGGLTLQLSHNLNNLIPLGSTVPINLPIINEIFSSPEAIQIPHTNPLARMRNTVGRYIPPEVVAVRVPLLHLSNFTNDWAELSTRSYAVMVLVLPMNGLRKWREHELELVQVVADQVAVALSHAAILEDSMRAHDQLMEQNIALDVARQEAEMAIRARNDFLAVMNHEMRTPMHAVIALCSLLLETDLTPEQRVMIETILKSSNLLATLINDVLDLSRLEDGILELENGTFNLHGILREAVNLIKPIASLKKLSITLALALDLPILAVGDAKRLIQTLLNVAGNAVKFTKEGHISIEASVAKPEYARDCHPPEMFPMPSDGQFYLRVQVRDTGCGISPQDIPLVFTKFAESRPTSNRSTGGEGLGLAICRRFIQLMKGNIWIESEGPGKGTTVTFVVKLGICHHPNALPLLPMPPRGRLNKGSDDLFRYRQFRGDDGGMSVNAQRYQRSL
Protein: Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein multitype 1) (O35615)
Organism: Mus musculus (Mouse)
Function: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
Subcellular location: Nucleus {ECO:0000269|PubMed:9230307}.
Interaction partners:
- Erythroid transcription factor
- Endothelial transcription factor GATA-2
- Rhombotin-2
- LIM domain-binding protein 1
- Histone deacetylase 1
- T-cell acute lymphocytic leukemia protein 1 homolog
- Krueppel-like factor 1
- Histone-binding protein RBBP7
- Transcription factor GATA-4
- Trans-acting T-cell-specific transcription factor GATA-3
Sequence:
MSRRKQSNPRQIKRSLRDMEAGEEAKAMDSSPKEQEAPDPEAPAIEEPPSPPREDVSPPAVPAPPESPEDPEDMEGQELEMRPQDEEKEEKEEEAAMASPWSGPEELELALQDGQRCVRARLSLTEGLSWGPFYGSIQTRALSPEREEPGPAVTLMVDESCWLRMLPQVLTEEAANSEIYRKDDALWCRVTKVVPSGGLLYVRLVTEPHGAPRHPVQEPVEPGGLAPVHTDIQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQRAGSPVSATEEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHNCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPAAKLPPDSLAGFQQHSLMHSPLVPADKAPTPSSGLDSKAEVTNGETRVPPQNGGSSESPAAPRTIKVEAAEEPEATRASGPGEPGPQAPSRTPSPHSPNPVRVKTELSSPTPGSSPGPGELTMAGTLFLPQYVFSPDAGTTTVPTAPQASEILAKMSELVHNRLQQGAGSSGAAGTPTGLFSGTKGATCFECEITFNNINNFYVHKRLYCSGRRAPEDPPTVRRPKAATGPARAPAGAAAEPDPSRSSPGPGPREEEASGTTTPEAEAAGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPPAPTTAPGPAAPALTAPPVRTRRRRKLYELPAAGAPPPAAGPAPVPVVPSPTAELPSSPRPGSASAGPAPALSPSPVPDGPIDLSKRPRRQSPDAPTALPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPLRTTALCPYCPPNGRVRGDLVEHLRQAHGLQVAKPAASPGAEPRTPAERAPRDSPDGRAPRSPSPAPENTPSDPADQGARTPSKGPPAPAPAPGGGGGHRYCRLCNIRFSSLSTFIAHKKYYCSSHAAEHVK
Protein: Uncharacterized protein C737.05 (O13679)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MQNELNPILLSQNSIRFATRVAIFFIIRDELVEAVTWRHPVKSMCLGLTITLLYLHPVSFSAILLLVFLTMMPISMTHDVTTNLKDLQNFMASYSSSYDQLLYFRQNYYHHITPSAISSGLLVSLVLIFLLAYLRISIDRYLPIAIWIGLISLHPKLRSYLIQFYSAKRDHVPYLQIRNELAQVWRHVDISGSQTTTRYTSFPKFNPENSVTSLDLVEPPENYSWAPQSDWTFVPPNEFRRFILWSPQPPKMNRKSSHGSNLPL
Protein: PID domain-containing protein (B5BM46)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNWIVHQQGSSNTMFYKCRPPIEFRFHKQTILGLKYDGLDRSSRSATSTIWVYDKCEFDNMIVPFMRHRPRNWDQESRYTAPRLMLCDTMSASQGNVFTRGLSRISRRKKKTKSIQNSLVSEQQPSFDAAIVPMPIPNDKSSIFSKGMDRLRRSLRLPKKRRDRSHDRHLSPDVTGGSKTEQWQPDEGAVRTGTCCFNVKYLGSVEVYESRGMQVCEGALKSLKASRRKPVKAVLYVSGDGLRVVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLATKETGERLSHAVGCAFSICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFHPNWEDNTSEGTSTQNPSNSRSNLAYQSFRKHVSIEDRYLDPQSVIINEVPASNHMDEIRRISKPRPTGNPALFLRQGSLRAPPDMPSSSDQFKRNMSLRTVSNNPTERSPEKKSFGTQLYNEPIYEGDEDPLGLGITPPVVTKTSGSLSNNGLDGINLNWKSIPAPVHQMQQHNANGDFVAAWPQNTIEKPTVGPLDKLQKQFEDIKLISISSGENTPTTRSKADEWLDDVLRVSMSMSPTSPSSDPPSTSSYSVLPKSGPPPAHAPPPLPVRQAVSNGSPSIYQQQLQQANSTRNSPAGINWNSSPNPMKISQPPAKPVDPFDVQWSRLAVNNTH
Protein: Pro-FMRFamide-related neuropeptide FF (FMRFamide-related peptides) [Cleaved into: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF (NPAF)] (O15130)
Organism: Homo sapiens (Human)
Function: Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.
Subcellular location: Secreted.
Interaction partners:
- Neuropeptide FF receptor 1
- Neuropeptide FF receptor 2
- Proto-oncogene Mas
- Prolactin-releasing peptide
- Prolactin-releasing peptide receptor
- Orexigenic neuropeptide QRFP
- Mas-related G-protein coupled receptor member D
- Metastasis-suppressor KiSS-1
- Mas-related G-protein coupled receptor member X2
- Mas-related G-protein coupled receptor member X3
Sequence:
MDSRQAAALLVLLLLIDGGCAEGPGGQQEDQLSAEEDSEPLPPQDAQTSGSLLHYLLQAMERPGRSQAFLFQPQRFGRNTQGSWRNEWLSPRAGEGLNSQFWSLAAPQRFGKK
Protein: Processing protease (Q9KA85)
Organism: Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) (Bacillus halodurans)
Interaction partners:
- Cytochrome c oxidase subunit 2
- Rieske [2Fe-2S] iron-sulfur protein
- Menaquinol:cytochrome c reductase iron-sulfur subunit
- BH2406 protein
- BH0305 protein
- BH1562 protein
- Menaquinol:cytochrome c reductase cytochrome b subunit
- Menaquinol:cytochrome c reductase cytochrome c subunit
- BH2393 protein
- Quinol oxidase subunit 3
Sequence:
MINTMTLDNGVRIITEKMSTVRSVSIGIWVGTGSRYESAEENGISHFLEHMFFKGTNTRSAQEIAEFFDSIGGQVNAFTSKEYTCYYAKVLDDHAGQAIDTLSDMFFHSTFQKEELEKERKVVFEEIKMVDDTPDDIVHDLLSSATYGKHSLGYPILGTVETLNSFNEGMLRHYMDRFYTGDYVVISVAGNVHDELIDKIKETFSQVKPTTYNYQGEKPMFLPNRIVRKKETEQAHLCLGYPGLPIGDKDVYALVLLNNVLGGSMSSRLFQDIREKRGLCYSVFSYHSSFRDSGMLTIYAGTGHDQLDDLVYSIQETTSALAEKGLTEKELENGKEQLKGSLMLSLESTNSRMSRNGKNELLLKKHRSLDEMIEQINAVQKQDVSRLAKILLSASPSISLINANGELPKALIH
Protein: Coiled-coil domain-containing protein 32 (Q8BS39)
Organism: Mus musculus (Mouse)
Function: Has a role in ciliogenesis. Required for proper cephalic and left/right axis development (By similarity).
Subcellular location: Membrane, coated pit {ECO:0000250|UniProtKB:Q9BV29}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BV29}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9BV29}.
Interaction partners:
- Large ribosomal subunit protein bL32m
Sequence:
MKMFESLDSSATKSGRDLWAEICSCLPSPAQEDVSDNAFSDSFMDSHPAGESHTAAADSAVQPAGKPWAPLHDSEVYLASLEKKLRRIKGLNEEVTSKDMLRTLAQAKKECWDRFLQEKLASEFFVDGLDSDERTLEHFKRWLQPDKVAISTEEVQFLIPPESQAEKPEAGDKPAAAEQ
Protein: Fer-1 like family member 6 (E0CZ42)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MFGLKLKKKKKDKAEKGLVLTNKGAQDGNESEIPQKGPSHQEGPEDLTKDDAFLAPGPSAPSKRRAKLLTKIHDGEIKSQNYQITVTITEARQLVGENIDPVVTIEIGDDKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVLHHKLIGSILIGSFRVDVGTVYNQPGHQFCDKWALLTDPGDIRTGTKGYLKCDISVTGKGDILKTNPKTSDAEEQIEKNLLIPQGFPSERPWARFYVRLYRAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQTGRTSVQKNCADPVWHEQVVFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHSLMDDYQELNEGFGEGVSFRGRILVEIAVEILSGGAQESKFSKALKELKLSSKDKDSKSSKGSSKDKADKADDSKAQQTTDKTNSTEVEVESFAVPPEIIPEKYEDFLLFGAFFEATMIDRKIGDKPISFEVSVGNFGNLIDGGSHHGSKKKSTELTEEDVLPLLHEGEKDVAQDSAISMASTTHPEKPLVTDGNRNYNYLPFGAKKPCVSFISSWGDQTFRLHWSNMLEKMADLLEEGIEEVRELVKVSQEAPEEKMKTALRDFITQSRVFISEAEKKPKTLNQTALDKKRLTLCWQELKAMADEAEGVIRQQKKKLSLDEMIREAQNFVEKIHFLVDEPQHTIPDVFIWMLSNNKRVAYARIAAKDLLYSPIEEQMGKHCGKIKTHFLKLPGKRPPGWTVQAKVDIYLWLGSTRYSNTILDNLPVGYEAEMPPKSSGTHHPPSALLYQAQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSQCQTTKIISQTLSPTWNQMLLFNELVLHGEEKELLESPPHVVVELYDSDAVGKPEYLGATVAAPVVTLADQDYEPPKLSYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPTGPPDITQIYPVPSNIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQVLIECGGGGVKSCVIQSYKNNPNFSVQAEAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINCLKQFLCKPRETFALTSQTDGDGARPAISDSLAATESSNLLSSSQDLPADHVYVDVEPPPTMLPDSAQAQTATLVDIPDSSPMLETEHKPVAQGPPKDGHGKDPRKPSRRSTKRRRRTIADESAENVIDWWSKYYASVKRAQKEKENNHKEKRATEAKPDEVVLDMEDGPKRKKDKMLKKKLKDDGNDAIPNLAALKIYDGDLESEFNNFEDWVKTFELFRGKSTEEDHGLDGDRVIGKFKGSFCIYKSPEDSTSEDSGQLRIQQGIPPNHPVQVLIRVYIVAAFNLSPADPDGKSDPYIVLRLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSVLIYDHDMIGSDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFRPGKIQIGKKVFSGKTVFNEEDSEEMVESYEHLALKVLHSWEDIPEAGWRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDTPQLGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWIKGLEDDRQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKSAKACDLSKFENAVQENKISIFQQKRVRGWWPFAKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFVSPFKCLYHLIWKNYKKYIIIAFILIILIVFLVLFIYTLPGAISRRIVVGGS
Protein: Uncharacterized protein (Q8C769)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
TAAPRIRPFSGRFPGARGWRILGVVAGLCVVKHEVPSDTVVWRPAVYRTVHSFALTLLKTCFWYFHFDRTNFFFRFQRCGRTSHEMEDFRGIAEESFPSFLANSLLGNSEVLGNVTLSSNFGLPIAVSTLARSRPSTDNRCPDVQESYLIEERFSVPSASSPSCQSDNPEPRERLRLSFQGDDSALRKKNYIESPDLSHALMKPRAEEKQANAASVQGQSLLGGVSPLQQVPDSALDFHLKSWTNHEEHNIAMPDPKKHFEAVNPNRDFSHTSLLDNEKLLTLTNLDSSSDDDINDEEFYDDHLEAYFEQLAIPGMMYEAGGQESPADDFKFPANEDSILNCEFQSENNSPRLPHDACTSGNSPTAHTESEGGHGCPPGTSGCVGTVDNKMQVDNVMSLYSHAWRNEKEAAHNLKDIVPNQSRGCGGEEIVVKRLCAVDETLRSTYRHSTETEDGFDPADYIKQDSESPHQNKHFASDLETVPNVDRCLNTETPTVFIQKDGDIAASSKTNGDNGINSPNTLWSPTSERRACGLYESDSKTSDKGELSQNVVYKSEDGRWVTDLAYYTSFIDQQDLQMSPNNEMNEDFRSGSDALDLIA
Protein: 26S proteasome non-ATPase regulatory subunit 11 homolog (19S proteosome subunit 9) (AtS9) (26S proteasome regulatory subunit RPN6) (AtRPN6) (26S proteasome regulatory subunit S9 homolog) (Q9LP45)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6A is required for proteasome assembly (By similarity).
Interaction partners:
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome regulatory subunit 6A homolog A
- 26S proteasome non-ATPase regulatory subunit 1 homolog B
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome regulatory subunit 4 homolog B
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- 26S proteasome non-ATPase regulatory subunit 8 homolog A
- 26S proteasome non-ATPase regulatory subunit 12 homolog B
- 26S proteasome non-ATPase regulatory subunit 14 homolog
Sequence:
MVSYRATTETISLALEANSSEAITILYQVLEDPSSSPEAIRIKEQAITNLCDRLTEEKRGEDLRKLLTKLRPFFSLIPKAKTAKIVRGIIDAVAKIPGTTDLQITLCKEMVEWTRAEKRTFLRQRVEARLAALLMENKEYVEALALLSTLVKEVRRLDDKLLLVDIDLLESKLHFSLRNLPKAKAALTAARTAANAIYVPPAQQGTIDLQSGILHAEEKDYKTGYSYFFEAFESFNALGDPRAVFSLKYMLLCKIMVSQADDVAGIISSKAGLQYVGPDLDAMKAVADAHSKRSLKLFENALRDYKAQLEDDPIVHRHLSSLYDTLLEQNLCRLIEPFSRVEIAHIAELIGLPLDHVEKKLSQMILDKKFAGTLDQGAGCLIIFEDPKADAIYSATLETIANMGKVVDSLYVRSAKIMS
Protein: KRAB-containing zinc-finger protein KRAZ1 (Zinc finger protein 53) (Q9Z117)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MEQNKETWKMERQEAVAKDPGPQASYSLFFKEKIKEETQKEMAGSPLIMSQRLLTFGDVAVEFPQEEWECLDSAQRALYIDVMLENYSNLVSVENYCISDTVHQHVKTEKESCQGNELGEMLHEPTNCALYIRRDTIETSNNYRCSKDRDGSVDLLNQDRHKSTHTGEELCKSEDCEKSLSLSSNLTENQRLYAANKLQSQGEYDDDFSSVYSLMQQTIYIGDTPHQCEKCRKCFSTASSLTVHKRIHTGKKPYKCSVCGKSFTQCTNLKTHQRLHTGEKPYKCKECGKSFPQLSALKSHQKIHTGERPYKCKECDKSFAHCSSFRRHQKTHRAEEHCSCPECGKVLHQLSHLRSHYRLHTGEKPYKCNECDRSFTYYASYRRHQKTHSLDKFYKCKECGKSFLELSHLKRHYRIHTGEKPYKCEVCDKSFTVNSTLKTHLKIHTGEKPFKCRECDKSFTKCSHLRRHQSVHTGEKPYRCKECDKSFTECSTLRAHQKIHTGEKPYKCRECDKSFIQRSNLIIHQRVHTGERPYICKECGKSFTKCSTLQIHQKIHTGEKPYKCMECNKSFTQDSHLRTHQRVHTGERPYICKECGKSFTRCSYLRAHQKIHTGEKPYKCKDCDISFIQISNLRRHQRVHTGEKNTIATIVT
Protein: ESX-1 secretion system protein EccA1 (ESX conserved component A1) (Type VII secretion system protein EccA1) (T7SS protein EccA1) (P9WPH9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- ESX-1 secretion-associated protein EspH
- ESX-1 secretion-associated protein EspG1
- ESX-1 secretion system protein EccCa1
- ESX-1 secretion system ATPase EccB1
- ESX-1 secretion-associated protein EspF
- ESX-1 secretion system protein EccCb1
- ESX-1 secretion-associated protein EspE
- ESAT-6-like protein EsxB
- FHA domain-containing protein
- PPE family immunomodulator PPE68
Sequence:
MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGKWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKVAAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAAADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAEAIAAVHAHLNMRE
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q38ES8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Clathrin coat assembly protein, putative
- Clathrin heavy chain
- ADF-H domain-containing protein
Sequence:
MGRPFRIVQRLSEKVLNPEAKSSKKSSKKAKDVYSYIVVVENIEALPMFARYVVVKRTFFKIDEVLLAHREPEILNRVRDKGILHVFHSEVTRNDGRLGTTVAMEYCPGSLEQRLQQETRMLESEVVQVLLALASVLGYLHSRQPPVAHRNINPSNVLIHSESAGASAYRLYNFRSAMTEAYHCENHEEVVAAMEDFARYTTAGYRAPEMLDPSSHKRIDEQVDMWALGVLLYYTMYQRLPFTDACWGLARKPKLRYPVEAEVWYTGSLRIVLEHLLEPDPEKRWDAFALINFMRFDNDLCRHIGPFCFSQTERPEGWEPQDVKVIGRPVPAKVLPERLRNTGQSDDPAAAARDNRDEAAATSVKSRTAAQESGDNDQMVLKAVTALSSDTASTDPEVLAYREKLIREQEEAWQVAESAHKKRDKEDKDGATSGPADVDSLFGPTEKKEAVKENKASAIDDLFGGMETQPSQSQKPTTDDLFGGASTATASNQIPPQGSQVGANDSWKDDLFAAPPQQPQMQPQPAFPMAADSSWSTGAPTSVPMNPTGGMMGQQQAPMGWGNGVTAPGFQPMQTPQMQQQVPGGWGNGATASGFQPMQTPQMQQQVPGGWGNGATAPSFQPMQTPQMQQQVPGGWGNGATAPGFQPMQTPQMQQQVPGGAPGFMGGNDLFQRPQQQQPQQPEKDPFASLFK
Protein: Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132) (P34902)
Organism: Mus musculus (Mouse)
Function: Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P31785}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:P31785}.
Interaction partners:
- Interleukin-7
- Interleukin-15
- Interleukin-2 receptor subunit alpha
- Interleukin-9
- Interleukin-4 receptor subunit alpha
- Interleukin-4
- Interleukin-2 receptor subunit beta
- Tyrosine-protein kinase JAK3
- Interleukin-2
- Interleukin-15 receptor subunit alpha
Sequence:
MLKLLLSPRSFLVLQLLLLRAGWSSKVLMSSANEDIKADLILTSTAPEHLSAPTLPLPEVQCFVFNIEYMNCTWNSSSEPQATNLTLHYRYKVSDNNTFQECSHYLFSKEITSGCQIQKEDIQLYQTFVVQLQDPQKPQRRAVQKLNLQNLVIPRAPENLTLSNLSESQLELRWKSRHIKERCLQYLVQYRSNRDRSWTELIVNHEPRFSLPSVDELKRYTFRVRSRYNPICGSSQQWSKWSQPVHWGSHTVEENPSLFALEAVLIPVGTMGLIITLIFVYCWLERMPPIPPIKNLEDLVTEYQGNFSAWSGVSKGLTESLQPDYSERFCHVSEIPPKGGALGEGPGGSPCSLHSPYWPPPCYSLKPEA
Protein: Thiamine thiazole synthase (EC 2.4.2.60) (Thiazole biosynthetic enzyme) (P32318)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15544818, ECO:0000269|PubMed:16850348}. Nucleus {ECO:0000269|PubMed:16850348}. Note=Excluded from the vacuole. {ECO:0000269|PubMed:16850348}.
Interaction partners:
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5
- Thiamine biosynthetic bifunctional enzyme
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI11
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI12
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI13
- Thiamine pyrophosphokinase
- Thiamine transporter
- Thiamine biosynthesis regulatory protein
Sequence:
MSATSTATSTSASQLHLNSTPVTHCLSDIVKKEDWSDFKFAPIRESTVSRAMTSRYFKDLDKFAVSDVIIVGAGSSGLSAAYVIAKNRPDLKVCIIESSVAPGGGSWLGGQLFSAMVMRKPAHLFLQELEIPYEDEGDYVVVKHAALFISTVLSKVLQLPNVKLFNATCVEDLVTRPPTEKGEVTVAGVVTNWTLVTQAHGTQCCMDPNVIELAGYKNDGTRDLSQKHGVILSTTGHDGPFGAFCAKRIVDIDQNQKLGGMKGLDMNHAEHDVVIHSGAYAGVDNMYFAGMEVAELDGLNRMGPTFGAMALSGVHAAEQILKHFAA