wanglab/gogpt-training-data huggingface dataset:
Protein: Protein spinster (Protein benchwarmer) (Protein diphthong) (Q9GQQ0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage. Involved in TGF-beta-mediated synaptic growth regulation both pre- and postsynaptically via its function in endosomal storage regulation. Also required during oogenesis by regulating yolk spheres storage.
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:12408844}; Multi-pass membrane protein {ECO:0000269|PubMed:12408844}. Lysosome membrane {ECO:0000269|PubMed:12408844}; Multi-pass membrane protein {ECO:0000269|PubMed:12408844}.
Interaction partners:
- AT27166p
Sequence:
MSLKHQKQSYQPLPTAAAMDNPAMIQSSGSSGSSSSEEGGSREDVANLSPLGLPTTYSSQQLMPSDTDSMEEERHRLRPHHHHHHPLGEHHHIPGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKMQPGNENIVQDDVAFNFGVITMLAGLLGVPLGSFLSQYLVKRYPTADPVICAFGLLVSAPLLTGACLLVNSNSVGTYALIFFGQLALNLNWAIVADILLYVVVPTRRSTAEAFQILISHALGDAGSPYLVGAISEAIMKHLHKNPSDSGLTTELRSMSQVAGSAISNATQVIAEATTSLMETARSSASQEYSDVEQFEGLQYALFSTSFVEVLGGIFFIFTACFIIKDKYNATRGLQDATAQQQQRDERGQIA
Protein: Palmitoyl-protein thioesterase 1 (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) (E9PSE5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALKKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAHIIPFLG
Protein: SPI-1 type 3 secretion system translocon protein SctE (SPI-1 T3SS translocon protein SctE) (Cell invasion protein SipB) (Effector protein SipB) (Q56134)
Organism: Salmonella typhi
Function: Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:11293481}. Host membrane {ECO:0000250|UniProtKB:Q56019}; Multi-pass membrane protein {ECO:0000255}. Host cell {ECO:0000269|PubMed:10051653}. Note=Secreted via the type III secretion system 1 (SPI-1 T3SS) (By similarity). Also localizes to the cell cytoplasm in Salmonella-infected macrophages (PubMed:10051653). {ECO:0000250|UniProtKB:Q56019, ECO:0000269|PubMed:10051653}.
Interaction partners:
- Cell invasion protein SipD
- Chaperone protein SicA
- Cell invasion protein SipA
- SPI-1 type 3 secretion system translocon protein SctB
- Inositol phosphate phosphatase SopB
- Pathogenicity 1 island effector protein
- Antigen presentation protein SpaN)
- Secreted effector protein SptP
- Invasion protein InvA
- Type 3 secretion system secretin
Sequence:
MVNDASSISRSGYTQNPRLAEAAFEGVRKNTDFLKAADKAFKDVVATKAGDLKAGTKSGESAINTVGLKPPTDAAREKLSSEGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAAAKKLTQAQNKLQSLDPADPGYAQAEAAVEQAGKEATEAKEALDKATDATVKAGTDAKAKAEKADNILTKFQGTANAASQNQVSQGEQDNLSNVARLTMLMAMFIEIVGKNTEESLQNDLALFNALQEGRQAEMEKKSAEFQEETRKAEETNRIMGCIGKVLGALLTIVSVVAAVFTGGASLALAAVGLAVMVADEIVKAATGVSFIQQALNPIMEHVLKPLMELIGKAITKALEGLGVDKKTAEMAGSIVGAIVAAIAMVAVIVVVAVVGKGAAAKLGNALSKMMGETIKKLVPNVLKQLAQNGSKLFTQGMQRITSGLGNVGSKMGLQTNALSKELVGNTLNKVALGMEVTNTAAQSAGGVAEGVFIKNASEALADFMLARFAMDQIQQWLKQSVEIFGENQKVTAELQKAMSSAVQQNADASRFILRQSRA
Protein: YTH domain-containing family protein (F4KDJ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Proline transporter 2
Sequence:
MDPASSSSSNQRNRIVSSGERPVMADNGVQQQVSHDDGRNIVSSSYSSSVVPSPDPAPYYNVLQTPTNLYHYDWDIANSGYAQGINTWDGYPRYATTTPEAMHVPPVVYNDNSSLMYQYPGYGFNPYPSVMLEGQIPVSPAYYPQPFGAPSAMHYLPSDIDPTSAAYMIPYGQYGGGNYSGNQGDISLTSHIPYPQTMGILGPYDHNASQVALHGSGVASSSSLGGYYHVGSYQNPSSTPSYYGVDNRVRLTPDIGKRREKDQGSISSTSDLYGNRGPRASSRVKSKNSSKPCSTIGDSASDSSTAGPNPSLYNHPEFVTDYKNAKFFIVKSFSEDNVHRSIKYNVWASTPHGNKKLDTAYRDAEKMGGKCPIFLFFSVNASGQFCGVSEMVGPVDFEKDAGYWQQDRWSGQFPVKWHIVKDIPNNRFCHILLQNNDNKPVTHSRDSQEVKLRQGIEMLRIFKEYEAHTSILDDFGYYDELEGQKVGEDGTRKKAGEEETSVEQLSERLQAVKVEDGKEEEKKELIAD
Protein: Protein MEI2-like 1 (AML1) (MEI2-like protein 1) (Q8W4I9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable RNA-binding transcriptional activator that plays a role in meiosis and vegetative growth. May be a downstream effector of TOR signaling pathway and recruited by RAPTOR1 for TOR substrate.
Interaction partners:
- FRIGIDA-like protein 3
- Serine-rich adhesin for platelets-like protein
- Dirigent protein 1
- RNA-binding
Sequence:
MPSDIMEQRGVSTPSHFHEDIHITSERQFGFMKTDMMPENQGGRDRLSSMPKSSWTSESYQLKPQSSFSGSHPSGSPNARNTTNGSQWESSLFSSSMSDLFSRKLRLQGSDMLSTMSANTVVTHREEEPSESLEEIEAQTIGNLLPDEDDLFAEVTGEVGRKSRANTGDELDEFDLFSSVGGMELDGDIFSSVSHRNGERGGNNSVGELNRGEIPSRTLLVGNISSNVEDYELKVLFEQFGDIQALHTACKNRGFIMVSYCDIRAAQNAARALQNKLLRGTKLDIRYSISKENPSQKDTSKGALLVNNLDSSISNQELNRLVKSYGEVKEIRRTMHDNSQIYIEFFDVRAAAAALGGLNGLEVAGKKLQLVPTYPEGTRYTSQCAANDTEGCLPKTSYSNTSSGHIGRHFPGMISSTSSDGGSMRVIHNSIGSPVNSFIERHRSLSIPIGFPPSANGISASKPVGLQEHGHHFDNSNMGIQSMPNLHPHSFSEYVDNFANGSPYTSSAFSEMVSDGSKANEGFMIHNVRGVEGFSGGGIGSPMHQSSRRPINLWSNSNTQQQNPSSGMMWPNSPSHINSIPTQRPPVTVFSRAPPIMVNMASSPVHHHIGSAPVLNSPFWDRRQAYVAESLESSGFHIGSHGSMGIPGSSPSHPMDIGSHKTFSVGGNRMDVNSQNAVLRSPQQLSHLFPGRSPMGSMPGSFDSPNERYRNLSHRRSESSSSNADKKLYELDVDRILRGEDRRTTLMIKNIPNKYTSKMLLSAIDEHCKGTYDFLYLPIDFKNKCNVGYAFINLIEPEKIVPFFKAFNGKKWEKFNSEKVATLTYARIQGKTALIAHFQNSSLMNEDKRCRPILFHTDGPNAGDQEPFPMGSNIRSRPGKPRSSSIDNYNSFSISSVSENREETPNGTDPFLKEN
Protein: Ephrin B2 (A0A8I6AJ66)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MAMARSRRDSVWKYCWGLLMVLCRTAISRSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKEQADRCTIKKENTPLLNCARPDQDVKFTIKFQEFSPNLWGLEFQKNKDYYIIYASSAGSTRNNDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNLLGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRGGNNNGSEPSDVIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
Protein: Stage 0 sporulation protein J (P26497)
Organism: Bacillus subtilis (strain 168)
Function: Required for the initiation of sporulation and for normal chromosome segregation. Antagonizes sporulation inhibition by Soj. It probably interacts with a specific DNA site and other proteins involved in partitioning and cell division, and antagonizes Soj in response to cell cycle events related to chromosome partitioning.
Subcellular location: Cytoplasm, nucleoid {ECO:0000269|PubMed:18854156}.
Interaction partners:
- Sporulation initiation inhibitor protein Soj
- Chromosomal replication initiator protein DnaA
- DNA translocase SpoIIIE
- Cell division protein FtsZ
- Chromosome-anchoring protein RacA
- Segregation and condensation protein A
- Segregation and condensation protein B
- Septum site-determining protein DivIVA
- Chromosome partition protein Smc
- DNA translocase SftA
Sequence:
MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDDEALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEALMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLTLPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQNVPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILELLSERES
Protein: NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 4L) (NADH-plastoquinone oxidoreductase subunit 4L) (P0C332)
Organism: Oryza sativa (Rice)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01456}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01456}.
Interaction partners:
Sequence:
MMFEHVLFLSVYLFSIGIYGLITSRNMVRALICLELILNSINLNLVTFSDLFDSRQLKGDIFAIFVIALAAAEAAIGLSILSSIHRNRKSTRINQSNFLNN
Protein: Taperin (A2AI08)
Organism: Mus musculus (Mouse)
Subcellular location: Cell projection, stereocilium {ECO:0000269|PubMed:20170899, ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:30159668, ECO:0000269|PubMed:30380417, ECO:0000269|PubMed:35752427, ECO:0000269|PubMed:37952086}. Cell projection, microvillus {ECO:0000269|PubMed:24285636}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q4KMQ1}. Cytoplasm {ECO:0000250|UniProtKB:Q4KMQ1}. Note=Localized prominently at the basal taper region of hair cell stereocilia (PubMed:20170899, PubMed:30159668, PubMed:30380417, PubMed:37952086). Forms organized ring-like structures with diameters ranging from 150 to 200 nm in the stereocilium taper region (PubMed:37952086). Detected in microvilli of inner hair cell supporting cells (PubMed:24285636). Predominantly nuclear in non-stereocilium cells but can shuttle between the nucleus and the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q4KMQ1, ECO:0000269|PubMed:20170899, ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:30159668, ECO:0000269|PubMed:30380417, ECO:0000269|PubMed:37952086}.
Interaction partners:
- Chloride intracellular channel protein 5
- Whirlin
- Glutaredoxin domain-containing cysteine-rich protein 1
- Glutaredoxin domain-containing cysteine-rich protein 2
- Radixin
- Rho family-interacting cell polarization regulator 2
- Unconventional myosin-VIIa
- Fascin-2
- TRIO and F-actin-binding protein
- Phosphatidylinositol phosphatase PTPRQ
Sequence:
MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGQGSGAAPDGPNERLVLAESLGPLSQNPFMRLESERRRGTRPAQQLLELYCRVPGVRTIRADNILIIESAPGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAPASPVRLSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQESPTGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPSQRQWVSSATSANDSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPLAGRQFEEPKGEVGWASQSQGLGSQLVSTVDGAPALEKSPLAAEMQWAVRKGACPRPAISDTDKCVRWQRPASPPPFLPATAEAEPAEGLGVPGLAKNGQEPVRPGLPVTFIDEVDSEEEAFQEAKLPSSAVGVPSQYHLHPARPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQSQQGAEEQDAESLSGPHTTLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEGEEDGEEEEVGPDSEKPFTVFLPRATFVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQTPTDVELPPKEVMLTPASQNDLSDFRSEPALYF
Protein: Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Protein deacetylase HDAC8) (EC 3.5.1.-) (Protein decrotonylase HDAC8) (EC 3.5.1.-) (Q7SXM0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of non-histone proteins. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9BY41}. Chromosome {ECO:0000250|UniProtKB:Q9BY41}. Cytoplasm {ECO:0000250|UniProtKB:Q9BY41}. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation. {ECO:0000250|UniProtKB:Q9BY41}.
Interaction partners:
- Structural maintenance of chromosomes protein.
- Si:ch211-262i1.5
- Si:ch211-9d9.1.
- AT-rich interactive domain-containing protein 4B
- AT-rich interactive domain-containing protein 4A
- Mortality factor 4-like protein 1
- SDS3 homolog, SIN3A corepressor complex component)
- Structural maintenance of chromosomes protein
- F-box-like/WD repeat-containing protein TBL1XR1a
- F-box-like/WD repeat-containing protein TBL1X
Sequence:
MSEKSDSNDDKSRTRSVVYVYSPEYIQTCDSLSKVPNRASMVHSLIEAYGLLKYMRVVKPHVASIEEMAVFHTDSYLQHLHKISQDGDNDDPQSADFGLGYDCPVVEGIFDYAAAVGGATLTAAQNLLDGKCDVAINWAGGWHHAKKDEASGSCYVNDAVLGILKLREKYDRVLYVDVDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVTDTGLGKGRWYAVNVPFEDGVRDDRYCQTFTSVMQEVKALFNPEAVVMQLGADTMAGDPMCSFNMTPVGVAKCLTYILGWELPTLLLGGGGYNLANTARCWTYLTGTVLGQTLSSEIPDHEFFTEYGPDYSLEISPSCRPDRNESQHLERVISTIKGNLKNVV
Protein: Oligogalacturonide ABC transporter, permease component (E0SDC6)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}. Cell membrane {ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU363032}.
Interaction partners:
- Oligogalacturonide ABC transporter, permease component
- Predicted rhamnose oligosaccharide ABC transport system, substrate-binding component
- Oligogalacturonide ABC transporter, ATPase component
- Predicted rhamnose oligosaccharide ABC transport system, substrate-binding component
- Galactan ABC transport system, permease component
- Maltose/maltodextrin ABC transporter, permease protein MalG
- Maltose/maltodextrin transport system permease protein MalG
- N-Acetyl-D-glucosamine ABC transport system, permease protein 2
- sn-glycerol-3-phosphate transport system permease protein UgpE
- N-Acetyl-D-glucosamine ABC transport system, permease protein 2
Sequence:
MNENRMLGLAYISPYIIGLIVFTAFPFLSSFVLSFTEYDLMSPPTFTGLENYHRMFMEDDLFWKSMGVTFAYVFLTIPLKLIFALLIAFVLNFKLRGIGFFRTAYYVPSILGSSVAIAVLWRALFAIDGLLNSFIGVFGLDPVNWLGEPSLALMSVTLLRVWQFGSAMVIFLAALQNVPQSQYEAAMIDGASKWQMFLKVTVPLITPVIFFNFIMQTTQAFQEFTAPYVITGGGPTHYTYLFSLYIYDTAFKYFDMGYGAALAWVLFLVVAVFAAISFKSSKYWVFYSADKGGKNG
Protein: LIM and cysteine-rich domains protein 1 (Dyxin) (Q9NZU5)
Organism: Homo sapiens (Human)
Function: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}.
Interaction partners:
- Transcription factor GATA-6
Sequence:
MAKVAKDLNPGVKKMSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLRPRCSGCDEIIFAEDYQRVEDLAWHRKHFVCEGCEQLLSGRAYIVTKGQLLCPTCSKSKRS
Protein: Uncharacterized protein (Q38AV4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cdc23 domain-containing protein
- Cell division cycle protein 16, putative
- Anaphase-promoting complex subunit 2
- Cyclosome subunit 1, putative
- Anaphase-promoting complex subunit 11
- Rev7, putative
- Uncharacterized protein
- Anaphase-promoting complex subunit 10
- Dynein heavy chain region D6 P-loop domain-containing protein
- Ubiquitin-conjugating enzyme E2, putative
Sequence:
MDGGFPWTKHVEWNRFRNLGEGVGGFKGFRCCGGGQMRGLCGTELSVCCDCCLAVNESVHNRLAVGLKRATPEPLWQPTRLTSPYCILCANGLRDDFYTSCMSWGRESVALSLGEKVLLFKSSSPRESAVSLNLSGEACGYSESISSVAVSQFSDSHCFLGGVNGAVGLYESHGGGELSLSSSFEMPPPLFGGDLASEAAFSGATTSIRCLSTTNVHPWVVAAGTAAHGLFVLDSRFTTPAARMCGSDLWNSVDCRHSQRPLYPSEAISLLSSLNGICGVSWNSSGSLVATGESGGLVNIWSLSNTRSPVQRIRLPSAHTTVKAVAFHPTNPYELVLGGAADDGCVRVYDVSSATPHYKWGVSTGCQVTQALYSPDGSFIVSAHGARLKASVAIDAASAQSHATRAGVSRTDSGGGGWGAGDELQWLTEKFERAMKCSENAAESSIDTCLGFNRASSSGLNEAKPLLSEAPPFSLVMWRKGTQHQGTTPMSFTHGSGIHHQCAAGSPSRRCEPLPLVSMYTMMGHRSRPLQLAVPFSQTADQGCIASIAGGADCTIRFWKCFYSRSEMVNWGQRVCASLRTAITEEDVEEMTAMPLR
Protein: GDSL esterase/lipase 1 (EC 3.1.1.-) (Extracellular lipase 1) (Q9FLN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Confers resistance to the necrotrophic fungus Alternaria brassicicola. Possesses lipase and antimicrobial activities that directly disrupt fungal spore integrity. Triggers systemic resistance, mostly by the ethylene-dependent pathway.
Subcellular location: Secreted {ECO:0000269|PubMed:16126835}. Note=Secreted upon salicylic acid treatment. {ECO:0000269|PubMed:16126835}.
Interaction partners:
- Triacylglycerol lipase 1
- Protein WVD2-like 1
- GDSL esterase/lipase
- BRISC and BRCA1-A complex member 2
- Putative small RNA degrading nuclease 4
- Amino acid transporter AVT1J
- At2g44240/F4I1.5
- Cysteine/Histidine-rich C1 domain family protein
Sequence:
MENSQLVSITFLAYTIIISIGSINCIDNNNLVTNQSALFVFGDSVFDAGNNNYIDTLSSVRSNYWPYGQTTFKSPTGRVSDGRLIPDFIAEYAWLPLIPPNLQPFNGNSQFAYGVNFASGGAGALVGTFSGLVINLRTQLNNFKKVEEMLRSKLGDAEGKRVISRAVYLFHIGLNDYQYPFTTNSSLFQSISNEKYVDYVVGNMTDVFKEVYNLGGRKFGILNTGPYDCAPASLVIDQTKIRSCFQPVTELINMHNEKLLNGLRRLNHELSGFKYALHDYHTSLSERMNDPSKYGFKEGKKACCGSGPLRGINTCGGRMGLSQSYELCENVTDYLFFDPFHLTEKANRQIAELIWSGPTNITGPYNLKALFELN
Protein: Condensin complex subunit 3 (Chromosome assembly protein xCAP-G) (Chromosome-associated protein G) (Condensin subunit CAP-G) (Non-SMC condensin I complex subunit G) (Q9YHB5)
Organism: Xenopus laevis (African clawed frog)
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerase.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MVKEGKAMEIKEAFDLSQKAHQNHAKLVSSLRAAYNKTEDKSIFLEEFIHFLKFPLIVYRREPAVERVMDFVAKFVTSFHNSGGENEEEADEENSPVNCLFNFLLQSHGASSMAVRFRVCQLINKLLVNLPENAQIDDDLFDKIHDAMLIRLKDRVPNVRIQAVLALARLQDPSDPDCPVSNAYVHLLENDSNPEVRRAVLTCIAPSAKSLPKIVGRTMDVKEPVRKLAYQVLSEKVHIRALTIAQRVKLLQQGLNDRSAAVKDVIQKKLIQAWLQYSEGDVLDLLHRLDVENSPEVSLSALNALFSVSPVGELVQNCKNLDERKLIPVETLTPENVLYWRALCEHLKSKGDEGEAALENILPEPAVYARYLSSYLQTLPVLSEDQRADMTKIEDLMTKEFIGQQLILTIGCLDTSEEGGRKRLLAVLQEILVMQNTPTSLISSLAELLLFVLKDDDKRIQTVAEIISELREPIVTVDNPKDAAQSRKLQLKLADVKVQLIEAKQALEDSLTNEDYSRASELKEKVKELESLKTQLIKEAEEPEMKEIRVEKNDPETLLKCLIMCNELLKHLSLSKGLGGTLNEICESLILPGITNVHPSVRNMAVLCIGCCALQNKDFARQHLPLLLQILQLDEVKVKNSALNAVFDMLLLFGMDILKSKPTNPDDSQCKAQENADEDISEQEKPGSVDENLTNEEVQEETATVNGILHLFSGFLDSEIAEIRTETAEGLVKLMFSGRLISAKLLSRLILLWYNPVTEEDTKLRHCLGVFFPIFAYSCRSNQECFAEAFLPTLQTLFNAPASSPLADVDVANVAELLVDLTRPSGLNPQNKQSQDYQAAMVHDGLAIKICNEILKDPTAPDVRIYAKALCSLELSRENSTDLLPLLDCAVEDVTDKVCERAIEKVRSQLRSGREEHRVSKETEPQVSKETEDRTNLQENEEGKQKDEANCDENTDTVKEKAARGKATKGRRKGPAAAATRRKASKAEEAEAEMERQEESQCVPVNTRPSRRAKTAALEKTKKNLSKLLNEEAN
Protein: Indole-3-glycerol phosphate synthase (IGPS) (EC 4.1.1.48) (P9WFX7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Tryptophan synthase alpha chain
- Tryptophan synthase beta chain
- Anthranilate synthase component 1
- Anthranilate synthase component 2
- Anthranilate phosphoribosyltransferase
- Phosphoribosyl isomerase A
- Salicylate synthase
- Probable para-aminobenzoate synthase component I PABD
- Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
- Putative isochorismate synthase MenF
Sequence:
MSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGALATIADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTESLGMTALVEVHTEQEADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLAYAGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR
Protein: Renin-1 (EC 3.4.23.15) (Angiotensinogenase) (Kidney renin) (P06281)
Organism: Mus musculus (Mouse)
Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Subcellular location: Secreted {ECO:0000269|PubMed:9030738}. Membrane {ECO:0000250|UniProtKB:P00797}. Note=Associated to membranes via binding to ATP6AP2. {ECO:0000250|UniProtKB:P00797}.
Interaction partners:
- Renin receptor
- Angiotensinogen
- Angiotensin-converting enzyme
- Type-2 angiotensin II receptor
- Angiotensin-converting enzyme 2
- Proto-oncogene Mas
- Type-1 angiotensin II receptor A
- Mineralocorticoid receptor
- Kininogen-1
- Type-1 angiotensin II receptor-associated protein
Sequence:
MDRRRMPLWALLLLWSPCTFSLPTRTATFERIPLKKMPSVREILEERGVDMTRLSAEWGVFTKRPSLTNLTSPVVLTNYLNTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGSDFTIHYGSGRVKGFLSQDSVTVGGITVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSISKTDSWQITMKGVSVGSSTLLCEEGCAVVVDTGSSFISAPTSSLKLIMQALGAKEKRIEEYVVNCSQVPTLPDISFDLGGRAYTLSSTDYVLQYPNRRDKLCTLALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
Protein: GEL complex subunit OPTI (Obligate partner of TMCO1 insertase) (Rab5-interacting protein) (RIP5) (Respirasome Complex Assembly Factor 1) (RCAF1) (Q9CQT9)
Organism: Mus musculus (Mouse)
Function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (By similarity). In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A8I3S9V6}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:31536960}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Calcium load-activated calcium channel
- TBC1 domain family member 31
Sequence:
MSGGRRKEEPPQPQLANGALKVSVWSKVLRSDAAWDDKDEFLDVIYWFRQIIALVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFSNYLQIDEEEYGGTWELTKEGFMTSFALFMVIWIIFYTAIHYD
Protein: Small ribosomal subunit protein uS15z (40S ribosomal protein S13-1) (P59223)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS19x
- Small ribosomal subunit protein eS7x
- Small ribosomal subunit protein eS28x
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein uS10z/uS10x
Sequence:
MGRMHSRGKGISASALPYKRSSPSWLKTTPQDVDESICKFAKKGLTPSQIGVILRDSHGIPQVKSVTGSKILRILKAHGLAPEIPEDLYHLIKKAVAIRKHLERNRKDKDSKFRLILVESRIHRLARYYKKTKKLPPVWKYESTTASTLVA