wanglab/gogpt-training-data huggingface dataset:
Protein: TM2 domain-containing protein 2 (Beta-amyloid-binding protein-like protein 1) (BBP-like protein 1) (Q9BX73)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- TM2 domain-containing protein 1
Sequence:
MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSQNATAEPELTSAGAAQPEGPGGAASWEYGDPHSPVILCSYLPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY
Protein: Keratinocyte differentiation-associated protein (P60985)
Organism: Homo sapiens (Human)
Function: May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.
Subcellular location: Secreted {ECO:0000269|PubMed:15140226}.
Interaction partners:
- Suprabasin
- Cornifelin
- Dermokine
- WAP four-disulfide core domain protein 5
Sequence:
MKIPVLPAVVLLSLLVLHSAQGATLGGPEEESTIENYASRPEAFNTPFLNIDKLRSAFKADEFLNWHALFESIKRKLPFLNWDAFPKLKGLRSATPDAQ
Protein: Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor) (P04823)
Organism: Rattus norvegicus (Rat)
Function: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (By similarity). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Interleukin-3 receptor subunit alpha
- Interleukin-5
- Colony stimulating factor 2 receptor subunit beta
- Interleukin-2
- Granulocyte-macrophage colony-stimulating factor
- Kit ligand
- Interleukin-6
- Interferon gamma
- Interleukin-1 alpha
- Interleukin-7
Sequence:
MVLASSTTSILCMLLPLLMLFHQGLQISDRGSDAHHLLRTLDCRTIALEILVKLPVSGLNNSDDKANLRNSTLRRVNLDEFLKSQEEFDSQDTTDIKSKLQKLKCCIPAAASDSVLPGVYNKDLDDFKKKLRFYVIHLKDLQPVSVSRPPQPTSSSDNFRPMTVEC
Protein: Kremen protein 1 (Dickkopf receptor) (Kringle domain-containing transmembrane protein 1) (Kringle-containing protein marking the eye and the nose) (Q99N43)
Organism: Mus musculus (Mouse)
Function: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (By similarity). Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27550540}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Dickkopf-related protein 1
- Low-density lipoprotein receptor-related protein 5
- Dickkopf-related protein 2
- Fanconi anemia group M protein homolog
- Low-density lipoprotein receptor-related protein 6
- Dickkopf-related protein 4
- Dickkopf-related protein 3
- Kremen protein 2
Sequence:
MAPPAARLALLSAAALTLAARPAPGPRSGPECFTANGADYRGTQSWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKHGEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMAAVVYSPDFPDTYATGRVCYWTIRVPGASRIHFNFTLFDIRDSADMVELLDGYTHRVLVRLSGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQATKEEPPQERPAVNQTLAEVITEQANLSVSAAHSSKVLYVITPSPSHPPQTAPGSHSWAPSVGANSHRVEGWTVYGLATLLILTVTAVVAKILLHVTFKSHRVPASGDLRDCRQPGASGDIWTIFYEPSTTISIFKKKLKGQSQQDDRNPLVSD
Protein: RNA polymerase II holoenzyme cyclin-like subunit (Q5B399)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Serine/threonine-protein kinase bur1
- cyclin-dependent kinase
- Transcription elongation factor spt5
- DNA-directed RNA polymerase subunit
- Serine/threonine protein kinase
- RNA polymerase II holoenzyme cyclin-like subunit
- Transcription elongation factor SPT4
- RNA polymerase II holoenzyme cyclin-like subunit
- CID domain-containing protein
- CDK-activating kinase assembly factor MAT1
Sequence:
MASQPPVKRPPPAPSNPVLLAAQKQWLFTDEELTRSPSQLSGMTVENENLHRSKGVNFITQVGIMLKLPQPTLATAAVYLHRFFMRYAIADKPERPGIHPYPIAATSLFLATKVEENVRRMKELVIAVCRVAQKKPDLVVDEQSKEFWKWRDTILHHEDILLEALCFDLQLEQPYRILYDFICFFRVNDNKHIRNSSWAFLNDSMYTVLCLQFPARVIAAAAFYAAASHCDIGFEDDEFGRSWWEQIDVDIAQVRRACTRMAELYESNSQHRHSQYYPPVPLAWKEGAEKTRIPRPGGSLDAPPDPSSRKRSREPEDSSKSSQQPSQDTASLKKEEASQNGARSPKRPRVGSDADQPRSAAGSLPQGGTHPHPPTTSPQSPQASSSFSHDRPPNGHHAHQSQRYQHPLPSAPRTTFPPRRNSETKNVDTIQQRIDQIVQQNSVPPKRATADKYRERDRDDEDAYQKRRPSYSSSTRNEHPPPPPPEHRQQPPPPPPPEPEPDDEGGGSEEGEL
Protein: Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] (Q00519)
Organism: Mus musculus (Mouse)
Function: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
Subcellular location: Cytoplasm {ECO:0000250}. Peroxisome {ECO:0000250}. Secreted {ECO:0000250}.
Interaction partners:
- Butyrophilin subfamily 1 member A1
- Uricase
- Guanine deaminase
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
- Thiopurine S-methyltransferase
- Hypoxanthine-guanine phosphoribosyltransferase
- Arylamine N-acetyltransferase 2
- Cytochrome P450 1A2
- Arylamine N-acetyltransferase 3
Sequence:
MTRTTVDELVFFVNGKKVVEKNADPETTLLVYLRRKLGLCGTKLGCGEGGCGACTVMISKYDRLQNKIVHFSVNACLTPICSLHHVAVTTVEGIGNTKKLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNKPEPTVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGSGNNPNCCMSQTKDQTIAPSSSLFNPEDFKPLDPTQEPIFPPELLRLKDTPRKTLRFEGERVTWIQVSTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPLIICPAWILELTSVAHGPEGISFGAACPLSLVESVLADAIATLPEQRTEVFRGVMEQLRWFAGKQVKSVASIGGNIITASPISDLNPVLMASRAKLTLASRGTKRTVWMDHTFFPGYRRTLLSPEEILVSIVIPYSRKGEFFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELSLCFGGMADRTVSALKTTPKQLSKSWNEELLQDVCAGLAEELHLAPDAPGGMVEFRRTLTLSFFFKFYLTVLQKLGRADLEGMCGKLDPTFASATLLFQKDPPANVQLFQEVPKGQSEEDMVGRPMPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIMSIDTSEAKKVPGFVCFLTSEDVPGSNITGIFNDETVFAKDEVTCVGHIIGAVVADTPEHAHRAARGVKITYEDLPAIITIQDAIKNNSFYGPEVKIEKGDLKKGFSEADNVVSGELYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFIAKMLGVPDNRIVVRVKRMGGGFGGKETRSTLISTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLAKYKVGFMKTGTIVALEVAHFSNGGNSEDLSRSIMERAVFHMDNAYKIPNIRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSEVAVTCGLPAEEVRRKNMYKEGDLTHFNQKLEGFTLPRCWDECIASSQYQARKMEVEKFNRENCWKKRGLCIIPTKFGISFTLSFLNQGGALVHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHITETSTNTVPNTSPTAASASADLNGQAIYEACQTILKRLEPFKKKNPSGSWESWVMDAYTSAVSLSATGFYKTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTMEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKRAIYASKAVGEPPLFLASSIFFAIKDAIRAARAQHGDSNAKQLFQLDSPATPEKIRNACVDQFTTLCATGTPENCKSWSVRI
Protein: Jupiter microtubule associated homolog 1 (J3KT51)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRKNKMASNIFGTPEENQASWAKSAGAKSSGGREDLESSGLQRRNSSEASSGDFLDLKVSVTA
Protein: Movement protein BC1 (Movement protein BL1) (P0CK43)
Organism: Bean golden yellow mosaic virus (isolate Puerto Rico) (BGYMV) (Bean golden mosaic virus (isolate Puerto Rico))
Function: Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Begomovirus genome is shuttled out of nucleus by Nuclear shuttle protein (NSP) and the movement protein transports the DNA-NSP complex to cell plasmodesmata and facilitates further movement across the cell wall (By similarity).
Subcellular location: Host cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Host microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Host endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Found on ER-derived vesicles. {ECO:0000250}.
Interaction partners:
Sequence:
MDSQLANPPNAFNYIESQRDEYQLSHDLTEIILQFPSTASQLSARFSRSCMKIDHCVIEYRQQVPINATGSVVVEIHDKRMTDNESLQASWTFPIRCNIDLHYFSSSFFSLKDPIPWKLYYRVSDTNVHQRTHFAKFKGKLKLSTAKHSVDIPFRAPTVKILSKQFSNKDIDFSHVDYGKWERKLIRSASLSKYGLQGPIELKPGESWASKSTIGVSHLDADSDLDSAIHPYKNLNRLGSSVLDPGDSASIIGAQRAQSNITLSIAQLNEIVRSTVNECINNNCIHVQPKSLK
Protein: High mobility group B protein 10 (Nucleosome/chromatin assembly factor group D 10) (Q9LTT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds preferentially DNA with A/T-rich content.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:19053246}.
Interaction partners:
- Actin-related protein 4
- At3g01890
- Chromatin structure-remodeling complex protein BSH
- SWI/SNF complex component SNF12 homolog
- Actin-related protein 5
- Actin-related protein 4A
- Histone deacetylase complex subunit SAP18
- SWI/SNF complex subunit SWI3D
- Actin-related protein 8
- SWI/SNF complex subunit SWI3A
Sequence:
MSTDISPPYSQTHVEPVNGYPSDNKRCDDSSVPAKYDDLVRNSALFWEKLRAFLGLTSKTLKVPTVGGNTLDLHRLFIEVTSRGGIERVVKDRKWKEVIGAFSFPTTITSASFVLRKYYLKFLFQLEHVYYLEKPVSSLQSTDEALKSLANESPNPEEGIDEPQVGYEVQGFIDGKFDSGYLVTMKLGSQELKGVLYHIPQTPSQSQQTMETPSAIVQSSQRRHRKKSKLAVVDTQKPKCHRSGYNFFFAEQYARLKPEYHGQERSITKKIGHMWSNLTESEKQVYQDKGVKDVERYRIEMLEYKSSHESGATASTVAQ
Protein: DNA replication complex GINS protein SLD5 (Q03406)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for DNA replication. Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery.
Subcellular location: Nucleus {ECO:0000269|PubMed:12730134}.
Interaction partners:
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM4
- Chromosome segregation in meiosis protein 3
- Cell division control protein 45
- DNA replication regulator DPB11
- DNA replication complex GINS protein PSF2
- DNA polymerase alpha-binding protein
- DNA polymerase epsilon subunit B
- DNA polymerase epsilon catalytic subunit A
Sequence:
MDINIDDILAELDKETTAVDSTKITQGSSSTTHRDANTIVGSSLDLNDKTQIYVSPQQDFSDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDMQNASNANPPMPNESKLPLLCMETELERLKFVIRSYIRCRLSKIDKFSLYLRQLNEDENSLISLTDLLSKDEIKYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPPDGKWNEDPLLQENEFGKPCYTVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVALI
Protein: Phenazine O-methyltransferase PhzM (EC 2.1.1.-) (SAM-dependent O-methyltransferase) (A0A172J1V3)
Organism: Lysobacter antibioticus
Function: Involved in the biosynthesis of phenazine natural products including myxin, an N(5),N(10)-dioxide phenazine antiobiotic, which has antimicrobial activity. O-methyltransferase, which converts iodinin (1,6-dihydroxyphenazine N(5),N(10)-dioxide) to myxin (1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide). Catalyzes both monomethoxy and dimethoxy formation of phenazine natural compounds. Acts on a wide variety of substrates, catalyzing O-methylation of phenazines with non-, mono- or di-N-oxide. Highest activity with 1,6-dihydroxyphenazine (DHP) as substrate. Less active with monohydroxy-containing and monohydroxy-monomethoxy-containing phenazines. Least active with non-phenazine substrates, such as 8-hydroxyquinoline and 6-hydroxyquinoline. Is not able to convert 1-hydroxyphenazine to 1-hydroxy-N5-methylphenazine (pyocyanine), hence does not function as an N-methyltransferase.
Interaction partners:
Sequence:
MTENNRAGAVPLSSILLQMITGYWVTQSLYVAAKLGIADLVADAPKPIEELAAKTGAKAPLLKRVLRTIASIGVFTETEPGIFGITPLAALLRSGTPDSMRPQAIMHGEEQYRAWADVLHNVQTGETAFEKEFGTSYFGYLAKHPEADRVFNEAQAGYTKQVAHAVVDAYDFSPFKTVIDIGAGYGPLLSAILRSQPEARGILFDQPHVAQAAGKRLAEAGVGDRCGTVGGDFFVEVPADGDVYILSLLLHDWDDQRSIEILRNCRRAMPAHGKLLIVELVLPEGEEPFFGKWLDLHMLVLLGAQERTADEFKTLFAASGFALERVLPTASGLSIVEARPI
Protein: Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) (Q76EQ0)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Interaction partners:
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase
- Cystathionine beta-synthase
- Phosphoserine phosphatase
- Serine dehydratase-like
- Alanine--glyoxylate aminotransferase
- D-amino-acid oxidase
- PRKCA-binding protein
- Disrupted in schizophrenia 1 homolog
- serine C-palmitoyltransferase
Sequence:
MCAQYCISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSLSWVKQAERPAP
Protein: Small ribosomal subunit protein eS10 (40S ribosomal protein S10) (O77082)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Small ribosomal subunit protein eS30
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein eS17
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein uL1
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL30
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein uL15
Sequence:
MPLIPTENKLAIYRYLFQEGVLVAPKDFHLAKHPQIETVSNLDVLQILRSFKSRKFVTETFNWQYYYWVLTEEGIKYLRTYLQVPESVVPATMKKQASRPSTYTRSEETKRTGASGDFDPSFNRGDRRQGGDRRGGMGRGQYRTERSAPAPQQN
Protein: ADP-ribosylation factor-like protein 1 (P25160)
Organism: Drosophila melanogaster (Fruit fly)
Function: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Interaction partners:
- LD29171p
- Ras-related protein Rab6
- Arfaptin
- GRIP and coiled-coil domain containing 88 kDa
- FI04457p
- Golgin-245
- Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
- GEO08385p1
- Protein MON2 homolog
- Syntaxin 16
Sequence:
MGGVLSYFRGLLGSREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSADRDRIGISKDELLYMLREEELAGAILVVLANKQDMDGCMTVAEVHHALGLENLKNRTFQIFKTSATKGEGLDQAMDWLSNTLQSRK
Protein: Signal recognition particle subunit SRP72 (Q9FXD1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR038922}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
- Signal recognition particle subunit SRP68
- Signal recognition particle 14 kDa protein
- Signal recognition particle 9 kDa protein
- Signal recognition particle 19 kDa protein
- Cystatin/monellin superfamily protein
- AT4g30600/F17I23_60
- Signal recognition particle subunit SRP54 1
- Signal recognition particle subunit SRP54 2
- Signal recognition particle subunit SRP54, chloroplastic
- Signal recognition particle subunit SRP54 3
Sequence:
MAPKSKENPKTSTPAIEDLFTSLHKHIKDTKYEEAVKVADQVLSIVPTDEDAIRCKVVALIKDDKFDDYLIKDVKINGALSVINSFPIDLGFHKAYCLYRENKLDEALVCLKGLERESKTLLLEAQILNCLGKVDACVDVYQKLNKSGIKLIEVNLVAALIRAGKASQVLESLKIRPTTTYQLAYNTACSLIENSNYVDAEQLLLTAMRIGQETLTEGDYSDDYIETQLAPISVQLAYVQQVLGQTQESKSSYVDIIKRNLADESLALAVNNLVALKGSKDISDGLRKFDLLKDKDSQNFQLSQELDAKLSHKHKEAIYANRVLLLLHANKMDQARELCATLPGMFPESVIPTLLQAAVLVRENKAAKAEELLGQCAENFPEKSKLVLLARAQIAASASHPHVAAESLSKIPDIQHLPATVATIVALRERAGDNDGATAVLDSAIRWWSDSMTDSNMLRILMPVAAAFKLRHGQEEEASRLYEEIVKNHNSTDALVGLVTTLARVNVEKAEAYEKQLKPLPGLKAVDVDNLEKTSGAKPIEGISAASLSQEEVKKEKVKRKRKPKYPKGFDLENSGPTPDPERWLPRRERSSYRPKRKDKRAAQIRGSQGALTKVKQEEAPSTSKSKQAAISKANAAGPSSSKASKKKSRR
Protein: Retinoic acid early-inducible protein 1-epsilon (RAE-1-epsilon) (Q9CZQ6)
Organism: Mus musculus (Mouse)
Function: Acts as a ligand for KLRK1.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- NKG2-D type II integral membrane protein
- Retinoic acid early-inducible protein 1-delta
- Hematopoietic cell signal transducer
- UL16 binding protein 1
- Histocompatibility antigen 60c
- mRNA export factor
Sequence:
MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKDPTSADLPWCDVKCSVDEITILHLNNINKTMTSGDPGKMANATGKCLTQPLNDLCQELRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGDLVQQLKYFIPQCRQKIDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVGLIFISLLFAFAFAM
Protein: Hydroxyproline O-galactosyltransferase GALT4 (EC 2.4.1.-) (Beta-1,3-galactosyltransferase 17) (Q8GXG6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. Utilizes UDP-galactose solely as sugar donor. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:26690932}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Hydroxyproline O-galactosyltransferase HPGT1
- Hydroxyproline O-galactosyltransferase HPGT2
- Hydroxyproline O-galactosyltransferase HPGT3
- Beta-1,6-galactosyltransferase GALT31A
- Membrane protein
- Probable xyloglucan galactosyltransferase GT19
- Beta-1,6-galactosyltransferase GALT29A
- Beta-glucuronosyltransferase GlcAT14B
- Beta-glucuronosyltransferase GlcAT14C
- Beta-glucuronosyltransferase GlcAT14A
Sequence:
MKKSKLDNSSSQIRFGLVQFLLVVLLFYFLCMSFEIPFIFRTGSGSGSDDVSSSSFADALPRPMVVGGGSREANWVVGEEEEADPHRHFKDPGRVQLRLPERKMREFKSVSEIFVNESFFDNGGFSDEFSIFHKTAKHAISMGRKMWDGLDSGLIKPDKAPVKTRIEKCPDMVSVSESEFVNRSRILVLPCGLTLGSHITVVATPHWAHVEKDGDKTAMVSQFMMELQGLKAVDGEDPPRILHFNPRIKGDWSGRPVIEQNTCYRMQWGSGLRCDGRESSDDEEYVDGEVKCERWKRDDDDGGNNGDDFDESKKTWWLNRLMGRRKKMITHDWDYPFAEGKLFVLTLRAGMEGYHISVNGRHITSFPYRTGFVLEDATGLAVKGNIDVHSVYAASLPSTNPSFAPQKHLEMQRIWKAPSLPQKPVELFIGILSAGNHFAERMAVRKSWMQQKLVRSSKVVARFFVALHARKEVNVDLKKEAEYFGDIVIVPYMDHYDLVVLKTVAICEYGVNTVAAKYVMKCDDDTFVRVDAVIQEAEKVKGRESLYIGNINFNHKPLRTGKWAVTFEEWPEEYYPPYANGPGYILSYDVAKFIVDDFEQKRLRLFKMEDVSMGMWVEKFNETRPVAVVHSLKFCQFGCIEDYFTAHYQSPRQMICMWDKLQRLGKPQCCNMR
Protein: Cyclic GMP-AMP synthase-like receptor (Tc-cGLR) (cGLR) (EC 2.7.7.86) (D6WI29)
Organism: Tribolium castaneum (Red flour beetle)
Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity. Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (By similarity).
Interaction partners:
Sequence:
MENILNDINKRFISLPEEDVRGNKQILESVLRTFVEQMKTQDPLFKALFRRVFYGGSFYDGLKVGKPEEFDLDILLHIPIYAQPVLNESNVPGFVWLKLNNLDGWLRQPEGRVYKDFRKKFLADNDFLDTGKTLRWMESLVQKTLNTLPWVNNATCELTNEFGTFHINWWKGGPAMTLGISHSSGEKIMDVDLVACFVFSGDKWPINGYRSNPFPSTKPEFFIVPKKPQGPVNPQGRYWSLSFQEQERVLIDNKNRLKPAVKLIKKLKEKTHPNIASYYIKTVFLHIIEQKDQSFWNKSLREVFMTTLREYNEFIADQSIPYYWCRKNNLIGHLAPITLNNISNRIGYIIKDIENNPENIAKHLLTKEEYTKYIQGEDVMAEALPALPASQTSSCVII
Protein: Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Q7T1B9)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MFLRLALLGILLLSILGTETAQAGSSFLSPAYKNIQQQKDTRKPTARLHPRGTESFWDTDETAGEDDNNSVDIKFNVPFEIGVKITEREYQEYGQALEKMLQDIFEENAKETQTKD
Protein: Starvin, isoform C (Q9VU82)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDMDNMFPRSHLGRMHDPFAGFGDSRKRSSLHGPSGQVHADDDFPSYFDDPDFGFPRFSTMGRRGRMAGGANTHMDHDDDFFNRLPSEFRQYIPDGFGGRRGTGAAPAPGQVPQQQQPQPQPQYTQQQPQTHFQFGVPPQQQPVYAGPTQQQVPQTPSKRLCDAAIQTEDPAGRSEVDCAPPTNLNQHGLRNTVDMGVKSVAEQDQGLRSHSAPPPEQQQQNLQYHQQQQQHQQPGVHSQPFGTQTSPPVQGQQFKTYYAPHQQTHPQQKQQTPPPAPQTPGGTYVRTIPIFVEGRSEPIINAHKEIPNQNAPPSAQAQAQAQAYAQAQPQAHAAPQQHNRPTPLNTQAQPEQQVPVEGAAGLPPQTPHTLNSINKIQDIQRDVLELMGKVEQFKGTREEKEYAYLDEMLTRNLLKLDTIDTNGKDSIRLARKEAIKCIQASINVLEAKAEENARAASGAAPAPSATAPAVDTGAVAASEAAGQNAEPVTPQPQDATKMQEPIPLPAPPNAAAVEGAAASEATAAEATQSAVQSETTTTTSE
Protein: Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE) (Q01066)
Organism: Rattus norvegicus (Rat)
Function: Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q01064}.
Interaction partners:
- Calmodulin-1
- Calmodulin-like protein 3
- Calmodulin-like protein 4
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
- Adenosine kinase
- Adenine phosphoribosyltransferase
- Phosphodiesterase
- Inosine triphosphate pyrophosphatase
Sequence:
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTAVGPTYSTAVHNCLKNLDVWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLTDDDSKSKSQPSFQWRQPSLDVDVGDPNPDVVSFRSTWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPSSPAEDEHNQNGNLD
Protein: Homeobox A9 (A0A669KBC8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MATTGALGNYYVDSFLLGADAADELSVGRYAPGTLGQPPRQAATLAEHPDFSPCSFQSKATVFGASWNPVHAAGANAVPAAVYHHHHHHPYVHPQAPVAAAAPDVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE