wanglab/gogpt-training-data huggingface dataset:
Protein: Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Q9JMI1)
Organism: Rattus norvegicus (Rat)
Function: Converts acetoacetate to acetoacetyl-CoA in the cytosol. Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10682835, ECO:0000269|PubMed:3082367}.
Interaction partners:
- Acetyl-CoA acetyltransferase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
- Hydroxymethylglutaryl-CoA lyase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Acetyl-CoA acetyltransferase, cytosolic
- Peroxisomal bifunctional enzyme
- Dehydrogenase/reductase SDR family member 6
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
Sequence:
MSKLARLEREEIMECQVMWEPDSKKDTQMDRFRAAVGTACGLALGNYDDLYHWSVRSYSDFWAEFWKFSGIVCSRMYDEVVDTSKGIADVPEWFRGSRLNYAENLLRHKENDRVALYVAREGREEIAKVTFEELRQQVALFAAAMRKMGVKKGDRVVGYLPNSAHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHGHLEKLQRVVKGLPDLQRVVLIPYVLPREKIDISKIPNSMFLDDFLASGTGAQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHVLHGNMTSSDILLYYTTVGWMMWNWMVSALATGASLVLYDGSPLVPTPNVLWDLVDRIGITILGTGAKWLSVLEEKDMKPMETHNLHTLHTILSTGSPLKAQSYEYVYRCIKSTVLLGSISGGTDIISCFMGQNSSIPVYKGEIQARNLGMAVEAWDEEGKTVWGASGELVCTKPIPCQPTHFWNDENGSKYRKAYFSKYPGVWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVEAFDEVEDSLCVPQYNRDGEERVVLFLKMASGHTFQPDLVKHIRDAIRLGLSARHVPSLILETQGIPYTINGKKVEVAVKQVIAGKTVEHRGAFSNPESLDLYRDIPELQDF
Protein: CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Menage a trois) (RING finger protein MAT1) (F7EX11)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR003338}.
Interaction partners:
Sequence:
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLENTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQESEQRRLFIQKEEELQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKSMKPVTFSTGIKMGSLISLAPIQKLEEALYEYQPLQIETCGPQVPEQELLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPR
Protein: Transcription factor bHLH167 (Basic helix-loop-helix protein 167) (AtbHLH167) (bHLH 167) (bHLH transcription factor bHLH167) (F4I4E1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- At2g18210
- Large ribosomal subunit protein uL11z
- At5g20030
- Cinnamyl alcohol dehydrogenase 8
Sequence:
MGRAREIGEGNSSSLREQRNLREKDRRMRMKHLFSILSSHVSPTRKLPVPHLIDQATSYMIQLKENVNYLKEKKRTLLQGELGNLYEGSFLLPKLSIRSRDSTIEMNLIMDLNMKRVMLHELVSIFEEEGAQVMSANLQNLNDRTTYTIIAQAIISRIGIDPSRIEERVRKIIYGYIYFEA
Protein: Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO) (Testis/brain RNA-binding protein) (TB-RBP) (Q62348)
Organism: Mus musculus (Mouse)
Function: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus.
Interaction partners:
- Translin-associated protein X
- Protein argonaute-2
- Endoribonuclease Dicer
- Ribonuclease 3
- Protein argonaute-1
- Protein argonaute-3
- Protein argonaute-4
- RISC-loading complex subunit TARBP2
- Interferon-inducible double-stranded RNA-dependent protein kinase activator A
- ATP-dependent RNA helicase A
Sequence:
MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACGEK
Protein: Protein VAPYRIN (MtVpy) (Protein HERMES) (D3J162)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Required for arbuscular mycorrhizal (AM) symbiosis with AM fungi (e.g. Glomus versiforme and Gigaspora gigantea) both during fungal passage across root epidermis and for arbuscule formation in cortical cells; this symbiosis promotes phosphorus (P) and copper (Cu) uptake. Essential for infection by symbiotic nitrogen-fixing rhizobial bacteria (e.g. Sinorhizobium meliloti) leading to the formation of root nodules.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19912567, ECO:0000269|PubMed:21223389}. Nucleus {ECO:0000269|PubMed:19912567, ECO:0000269|PubMed:21223389}. Cell membrane {ECO:0000269|PubMed:26234213}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=In cells containing arbuscular mycorrhizal (AM) fungal hyphae and arbuscules, accumulates in small puncta that move through the cytoplasm, likely mobile spherical structures that are associated with the tonoplast referred to as 'tonospheres' (PubMed:19912567). Present in cytoplasmic strands below hyphopodia (PubMed:19912567). Observed associated with EX70I in zones adjacent to the periarbuscular membrane (PAM) around the arbuscule hyphal tips (PubMed:26234213). Occasionally observed in the nucleus of cells containing fungal hyphae (PubMed:19912567). {ECO:0000269|PubMed:19912567, ECO:0000269|PubMed:26234213}.
Interaction partners:
- Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase DMI-3
- Protein CYCLOPS
- Major sperm protein
- ABC transporter G family member STR2
- GRAS family transcription factor
- GRAS family transcription factor
- Protein NODULATION SIGNALING PATHWAY 2
- Myosin heavy chain-like protein, putative
- Ankyrin
- U-box domain-containing protein 1
Sequence:
MDRLIKLDPSNIVLIRVEEGQKCLGKITLNNVMYTMPVAFRIQPLIKTRYTIKPQSGIISPLASLVIEITYHPPQQQGSNNLPHSFPFSDDSFLLHSVLAPGAAIKEPSSMFDSVPSDWFTTKKKQVFIDSAIKVMFVGSQILTQLVEDGNSMDDIREVLEKSDPLWESVNSKDSQGQTLLHLAISKTRPDLVQLILEFKPDIEAINSVGSTPLEAASSSGESLIVELLLAHKANTEGSESSVFRPIHHASREGHMEILRLLLLKGARVDSLTKDGNTSLHLAVEEKRRDCARLLLANGARTDVRNMREGDTPLHIAAANGDENMVKLLLHKGATKYVRNKLGKTAFDVAAENGHSRLFDALRLGDNLCAAARKGEVRTIQKVLESGGVINGRDQNGWTSLHRAAFKGRMDAVRFLVEKGIDLDAKDEDGYTALHCAAESGHADVTEFLVKKGADVEARTNKGVSALQIVESLNYVGITRILVNGGASREGLGEKPPSAPSKIPFGRKVESGSVMTMKKKMSSRTRALRGSFDHSMPLAVL
Protein: Putative L,D-transpeptidase YciB (EC 2.-.-.-) (C0SP99)
Organism: Bacillus subtilis (strain 168)
Subcellular location: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
- GTP cyclohydrolase FolE2
- Zinc chaperone YciC
- High-affinity zinc uptake system membrane protein ZnuB
- Small ribosomal subunit protein uS14A
- High-affinity zinc uptake system protein ZnuA
- Uncharacterized protein YczL
- Cell division topological determinant MinJ
- Probable metal-binding protein YrpE
Sequence:
MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRKTAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKDDATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAEKLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS
Protein: Vacuolar protein sorting-associated protein 51 homolog (F1M4I4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000256|RuleBase:RU368010}. Recycling endosome {ECO:0000256|RuleBase:RU368010}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex. {ECO:0000256|RuleBase:RU368010}.
Interaction partners:
- Vacuolar protein sorting-associated protein 52 homolog
- Vacuolar protein sorting-associated protein 53 homolog
- Vacuolar protein sorting-associated protein 54
- Syndetin
- Syntaxin-6
- EARP and GARP complex-interacting protein 1
- Syntaxin-16
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 5
- Conserved oligomeric Golgi complex subunit 8
Sequence:
MAAAAAVGPGLGSGPGDSPEGSEADAPERRRKAHGMLKLYYGLSEGEATGHSAGSDPLDPTDLNGAHFDPEVYLDKLRRECPLAQLMDSETDMVRQIRALDSDMQTLVYENYNKFISATDTIRKMKNDFRKMEDEMDRLATNMAVITNFSARISATLQDRHERITKLAGVHALLRKLQFLFELPSRLTKCVELGAYGQAVRYQGRARAVLQQYQHLPSFRAIQDDCQVITARLAQQLRQRFREGCSGAPEQAECVELLLALGEPAEELCEEFLAHARGRLEEELSSLETELGPSPPAPDVLEFTDRGGNGFVGGLCQVAAAYQELFAAQGPAGAEKLAAFAQELGGRYFALVERRLAQEQGGSDNSLLVRALDRFHRRLRAPGALLAAAGLSESATEIVERVARERLSHHLQGLKAAFLSCLTDVRQALAAPRLAGKEGPSLAELLANVASSILSHIKASLASVHLFTAKEVSFSNKPYFRGEFCSQGVREGLIVGFIRSMCQTAQGFCDSPGEKGGATPPALLLLLSRLCLDYETATISYILTLTDEQFLVQDQSPVTPVSTLCAEARETARRLLTHYVKVQGLVISQMLRKSVETRDWLSTLEPRNVRAVMKRVVEDTTAIDVQVGLLYEEGVRKAQSSDSSKRTFSVYSSSRQQGRYAPSYTPSAPMDTNLLSNIQKLFSERIDVFSPVEFNKVSVLTGIIKISLKTLLECVRLRTFGRFGLQQVQVDCHFLQLYLWRFVADEELVHLLLDEVVASAALRCPDPVPMEPSVVEVICERG
Protein: Antigenic protein SchS34 (34 kDa secretory protein) (SchS34) (allergen Sta c SchS34) (C7E9V9)
Organism: Stachybotrys chartarum (Toxic black mold) (Stilbospora chartarum)
Subcellular location: Secreted {ECO:0000269|PubMed:18046622, ECO:0000269|PubMed:18242638}. Spore {ECO:0000269|PubMed:18046622, ECO:0000269|PubMed:18242638}. Spore wall {ECO:0000269|PubMed:18046622}. Cytoplasm {ECO:0000269|PubMed:18046622}. Note=Localizes primarily in the outer and inner layers of the spore wall and on the external wall surfaces. In the mouse lung spreaded with spores, located in spore walls along the outside surface of the outer wall and in the intercellular space surrounding spores, slowly diffusing to the surrounding tissues of mouse granuloma. {ECO:0000269|PubMed:18046622}.
Interaction partners:
Sequence:
AGPIASRQIVPNYPASSTSKGFHLVVNVTDPSADFTPSINNFYVNSIHVGAALNYVGVTAVPGRIFYQNGTAEEIRYAQSTVISDGATPPVPFGLSLRPDEGSDVVSTARLDAGPGTTGVRVSRFPEPYRFLQPETFLACNESLAYYQGDYFTVIKQADVTVGDDGSIDYNVPDNCISVRLIPECTELNELPEDAYASHEFAADTQCYDDVSALNWSEYGP
Protein: Metallothionein-like protein 4C (Class I metallothionein-like protein 4C) (MT-1-4b) (OsMT-I-4c) (OsMT1c) (Q2QNC3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Acts as reactive oxygen species (ROS) scavenger. Possesses superoxide anion and hydroxyl radical scavenging activities in vitro. Involved in ROS homeostasis during anther and pollen development.
Interaction partners:
Sequence:
MSCGGSCNCGSCGCGGGCGKMYPDLAEKITTTTTTATTVLGVAPEKGHSEGVGKAAESGEAAHGCSCGSSCRCNPCNC
Protein: Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) (O43187)
Organism: Homo sapiens (Human)
Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Interaction partners:
- Interleukin-1 receptor-associated kinase 1
- Interleukin-1 receptor-associated kinase 4
- TNF receptor-associated factor 6
- Myeloid differentiation primary response protein MyD88
- Interleukin-1 receptor-associated kinase 3
- Interleukin-1 receptor type 1
- Toll/interleukin-1 receptor domain-containing adapter protein
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- Toll-like receptor 4
- Tumor necrosis factor receptor superfamily member 16
Sequence:
MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIELFGP
Protein: Diacylglycerol O-acyltransferase 1 (DGAT) (EC 2.3.1.20) (Acyl-CoA-dependent diacylglycerol O-acyltransferase) (Acyl-CoA:monoacylglycerol acyltransferase) (MGAT) (EC 2.3.1.22) (Triacylglycerol synthase) (TAG synthase) (Q08650)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the terminal and only committed step in triacylglycerol (TAG) synthesis by using diacylglycerol (DAG) and fatty acyl-CoA as substrates. Required for storage lipid synthesis. Major DAG esterifying enzyme in stationary phase when TAG production is particularly active. Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains, and in ergosterol biosynthesis. Also has monoacylglycerol acyltransferase (MGAT) activity, catalyzing the acyl-CoA-dependent esterification of monoacylglycerol to diacylglycerol. Can also utilize ceramide instead of DAG, acylating the ceramides by attaching a fatty acid to the hydroxy group on the first carbon atom of the long-chain base to produce 1-O-acylceramides.
Subcellular location: Lipid droplet {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:21820081, ECO:0000269|PubMed:24868093}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:20225889, ECO:0000269|PubMed:21321129, ECO:0000269|PubMed:32349126}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to sites of lipid droplet biogenesis in the endoplasmic reticulum. {ECO:0000269|PubMed:32349126}.
Interaction partners:
- Phospholipid:diacylglycerol acyltransferase
- Phosphatidic acid phosphohydrolase 1
- Sterol O-acyltransferase 2
- Triacylglycerol lipase 3
- Lipid phosphate phosphatase 1
- Triacylglycerol lipase 4
- Diacylglycerol pyrophosphate phosphatase 1
- Triacylglycerol lipase 5
- Sterol O-acyltransferase 1
- Monoglyceride lipase
Sequence:
MSGTFNDIRRRKKEEGSPTAGITERHENKSLSSIDKREQTLKPQLESCCPLATPFERRLQTLAVAWHTSSFVLFSIFTLFAISTPALWVLAIPYMIYFFFDRSPATGEVVNRYSLRFRSLPIWKWYCDYFPISLIKTVNLKPTFTLSKNKRVNEKNYKIRLWPTKYSINLKSNSTIDYRNQECTGPTYLFGYHPHGIGALGAFGAFATEGCNYSKIFPGIPISLMTLVTQFHIPLYRDYLLALGISSVSRKNALRTLSKNQSICIVVGGARESLLSSTNGTQLILNKRKGFIKLAIQTGNINLVPVFAFGEVDCYNVLSTKKDSVLGKMQLWFKENFGFTIPIFYARGLFNYDFGLLPFRAPINVVVGRPIYVEKKITNPPDDVVNHFHDLYIAELKRLYYENREKYGVPDAELKIVG
Protein: Rhomboid-like protease (EC 3.4.21.105) (C6KT26)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362115}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362115}.
Interaction partners:
Sequence:
MSFRTRASNNFNNDYSHDSNLLINKYTTSFNNTFKRDIKFIQILFPSFDLYSITFFFSLLLIFLFVVIDIIFFNFSSPLFINEDVLKKIGINRFAVSNNYQYYKLVTATFLHSNIWNVLINTYYLMNIGTIIEKNYGKAEYIIIMILSVACGNLLTCATSKCLDVQMGISPILSGFIGLFLQDIIVHYYELIDKLSIFGNFIFSFLSLYLMISIFSYNGNVLGNVGGILAGVSYPYIFKSDNFHGNDKKLKIIFAIFITLLLSGSLASLIVFKC
Protein: Rap guanine nucleotide exchange factor 6 (E9PCH4)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Rap guanine nucleotide exchange factor 6
- Tyrosine-protein phosphatase non-receptor type 13
Sequence:
MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q8SZA4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MELGDSKLRAVRVLGQGTFGRVFLCHQNEVRGQPERKVCVKRIIVRNPKTELGLIKEEVYIISQLRHPHIVEFLRSFSHAGTVNIVMEYVPNGTLRDVIQQLPSGTGGVNQERLMGYFRDMVVGLEYLHIRCVIHRDIKPENMLLDANDRVRIADFGIANVHAPSTQLQAGMGTPMYMAPEAMSSQGKVDFKSDVWSLGLVLYELCLGRSPFAAFLDKNATPALLHTVVQALVRPRLDCQLIRRLYDPVWAQVCELMVVYEQERRICLPDIFTSTPA
Protein: Fatty acid 2-hydroxylase (EC 1.-.-.-) (Q9XVS0)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- Cholesterol 25-hydroxylase-like protein
- Fatty acid hydroxylase domain-containing protein
- Fatty acid hydroxylase domain-containing protein
- Alkylglycerol monooxygenase
- Importin N-terminal domain-containing protein
- Serine palmitoyltransferase 1
- Ceramide glucosyltransferase 3
- Ceramide glucosyltransferase 1
- Cytochrome-b5 reductase
- Putative sphingolipid delta
Sequence:
MGIGADEKKPLLVQLDGQYYDIADFAPKHPGGAKVLNRLAGEEIGEFIRGEKRIMGVRHEHSEAAYNMLERYNVNAIQKGDPLIESKSGMLFKVGSLGSEYWHWIHQPYDGTLRLFDSDVLESMTRTAWWVVPAVWMPIVITFSILSVLSFSTSTDVYNSILLWSAWFVIGVLTWTLTEYSLHRWVFHWKPSPDSPNQILLHFLAHGLHHKTPMDGDRLVFPPVPATLIVGIFYLIYSNTFQWPVFCAFGAGKLFGYVTYDMVHYYLHHGSPRPRSNLHFRKVYHHNHHFKNFDVGFGISTSLWDYVFHTLGMGPL
Protein: MAPK regulated corepressor interacting protein 2 (Protein FAM195A) (Q9BUT9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, Stress granule {ECO:0000269|PubMed:26184334}. Nucleus {ECO:0000269|PubMed:26184334}.
Interaction partners:
- Probable ATP-dependent RNA helicase DDX6
- Protein LSM12
Sequence:
MYTITKGPSKLVAQRRTGPTQQQVEGRLGELLKCRQPAPPTSQPPRAQPFAQPPGPWPLSSPGPRLVFNRVNGRRAPSTSPSFEGTQETYTVAHEENVRFVSEAWQQVQQQLDGGPAGEGGPRPVQYVERTPNPRLQNFVPIDLDEWWAQQFLARITSCS
Protein: Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (P38795)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- NAD-capped RNA hydrolase NPY1
- NAD-dependent histone deacetylase SIR2
- Nicotinamide mononucleotide adenylyltransferase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- NAD
- Nicotinate phosphoribosyltransferase
- NAD-dependent protein deacetylase HST1
- Nicotinamidase
Sequence:
MSHLITLATCNLNQWALDFEGNRDRILQSIKIAKERGARLRVGPELEITGYGCLDHFLENDVCLHSWEMYAQIIKNKETHGLILDIGMPVLHKNVRYNCRLLSLDGEILFIRPKIWLANDGNYREMRFFTPWMKPGVVEDFILPPEIQKVTGQRLVPFGDAVINSLDTCIGTETCEELFTPQSPHIAMSLDGVEIMTNSSGSHHELRKLNKRLDLILNATKRCGGVYLYANQRGCDGDRLYYDGCALIAINGTIVAQGSQFSLDDVEVVTATVDLEEVRSYRAAVMSRGLQASLAEIKFKRIDIPVELALMTSRFDPTVCPTKVREPFYHSPEEEIALGPACWMWDYLRRCNGTGFFLPLSGGIDSCATAMIVHSMCRLVTDAAQNGNEQVIKDVRKITRSGDDWIPDSPQDLASKIFHSCFMGTENSSKETRNRAKDLSNAIGSYHVDLKMDSLVSSVVSLFEVATGKKPIYKIFGGSQIENLALQNIQARLRMVLSYLFAQLLPWVRGIPNSGGLLVLGSANVDECLRGYLTKYDCSSADINPIGGISKTDLKRFIAYASKQYNMPILNDFLNATPTAELEPMTKDYVQSDEIDMGMTYEELGVFGYLRKVEKCGPYSMFLKLLHQWSPKLTPRQISEKVKRFFFFYAINRHKQTVLTPSYHAEQYSPEDNRFDLRPFLINPRFPWASRKIDEVVEQCEAHKGSTLDIMSID
Protein: Protein TONSOKU (Protein BRUSHY 1) (Protein MGOUN 3) (Q6Q4D0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone reader involved in homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. Specifically recognizes and binds histone H3.1 lacking methylation at 'Lys-27' (H3K27me1). Involved in structural and functional stabilization of chromatin; represents a link between response to DNA damage and epigenetic gene silencing. Required for cell arrangement in root and shoot apical meristems. May be involved, when interacting with TSA1, in the organization of spindle microtubules.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:15082530, ECO:0000269|PubMed:15125773, ECO:0000269|PubMed:15746155, ECO:0000269|PubMed:15964904, ECO:0000269|PubMed:21705754}. Chromosome {ECO:0000269|PubMed:35298257}. Note=During anaphase, relocalizes in spots close to the ends of spindle microtubules ahead of separating chromatids.
Interaction partners:
- Histone H3-like centromeric protein CENH3
- Histone H3-like 4
- Histone H3-like 1
- Histone H3-like 3
- Histone H3.3
- Histone H3-like 2
- Histone H3.1
- Histone H3-like 5
- Uncharacterized protein At4g12070/F16J13_140
- Myosin heavy chain-related protein
Sequence:
MGRLDVAAAKRAYRKAEEVGDRREQARWANNVGDILKNHGEYVDALKWFRIDYDISVKYLPGKDLLPTCQSLGEIYLRLENFEEALIYQKKHLQLAEEANDTVEKQRACTQLGRTYHEMFLKSEDDCEAIQSAKKYFKKAMELAQILKEKPPPGESSGFLEEYINAHNNIGMLDLDLDNPEAARTILKKGLQICDEEEVREYDAARSRLHHNLGNVFMALRSWDEAKKHIEMDINICHKINHVQGEAKGYINLAELHNKTQKYIDALLCYGKASSLAKSMQDESALVEQIEHNTKIVKKSMKVMEELREEELMLKKLSAEMTDAKGTSEERKSMLQVNACLGSLIDKSSMVFAWLKHLQYSKRKKKISDELCDKEKLSDAFMIVGESYQNLRNFRKSLKWFIRSYEGHEAIGNLEGQALAKINIGNGLDCIGEWTGALQAYEEGYRIALKANLPSIQLSALEDIHYIHMMRFGNAQKASELKETIQNLKESEHAEKAECSTQDECSETDSEGHANVSNDRPNACSSPQTPNSLRSERLADLDEANDDVPLISFLQPGKRLFKRKQVSGKQDADTDQTKKDFSVVADSQQTVAGRKRIRVILSDDESETEYELGCPKDSSHKVLRQNEEVSEESMYFDGAINYTDNRAIQDNVEEGSCSYTPLHPIKVAPNVSNCRSLSNNIAVETTGRRKKGSQCDVGDSNGTSCKTGAALVNFHAYSKTEDRKIKIEIENEHIALDSCSHDDESVKVELTCLYYLQLPDDEKSKGLLPIIHHLEYGGRVLKPLELYAILRDSSENVVIEASVDGWVHKRLMKLYMDCCQSLSEKPSMKLLKKLYISEVEDDINVSECELQDISAAPLLCALHVHNIAMLDLSHNMLGNGTMEKLKQLFASSSQMYGALTLDLHCNRFGPTALFQICECPVLFTRLEVLNVSRNRLTDACGSYLSTIVKNCRALYSLNVEHCSLTSRTIQKVANALDSKSGLSQLCIGYNNPVSGSSIQNLLAKLATLSSFAELSMNGIKLSSQVVDSLYALVKTPSLSKLLVGSSGIGTDGAIKVTESLCYQKEETVKLDLSCCGLASSFFIKLNQDVTLTSSILEFNVGGNPITEEGISALGELLRNPCSNIKVLILSKCHLKLAGLLCIIQALSDNKNLEELNLSDNAKIEDETVFGQPVKERSVMVEQEHGTCKSVTSMDKEQELCETNMECDDLEVADSEDEQIEEGTATSSSLSLPRKNHIVKELSTALSMANQLKILDLSNNGFSVEALETLYMSWSSSSSRTGIAQRHVKEETVHFYVEGKMCCGVKSCCRKD
Protein: Small ribosomal subunit protein uS15c (30S ribosomal protein S15, chloroplastic) (P0C468)
Organism: Oryza sativa (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MKKKGGRKIFGFMVKEEKEENWGSVEFQVFSFTNKIRRLASHLELHKKDFSSERGLRRLLGKRQRLLAYLAKKNRVRYKKLISQLDIRER
Protein: Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (KEX2-like endoprotease 3) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (P29121)
Organism: Mus musculus (Mouse)
Function: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida. Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (By similarity). May also participate in folliculogenesis in the ovaries.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:16371590, ECO:0000269|PubMed:21080038, ECO:0000269|PubMed:21302280}.
Interaction partners:
Sequence:
MRPSQTELWLGLTLTLALLAVRWASAQAPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKDPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIQQDLNILKAWNQGLTGRGVVISILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCAIRVVHTPTPILPRMLVPKNVTACSDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYFNTGTLYYYTLLLYGTAEDMTARPQAPQVTSRARACVQRDTEGLCQESHSPLSILAGLCLISSQQWWWLYSHPQQPVTEGQASCHPPVTPAAAA