wanglab/gogpt-training-data huggingface dataset:
Protein: Homeobox-leucine zipper protein ATHB-5 (HD-ZIP protein ATHB-5) (Homeodomain transcription factor ATHB-5) (P46667)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that acts as a positive regulator of ABA-responsiveness, mediating the inhibitory effect of ABA on growth during seedling establishment. Binds to the DNA sequence 5'-CAATNATTG-3'.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox-leucine zipper protein MERISTEM L1
Sequence:
MKRSRGSSDSLSGFLPIRHSTTDKQISPRPTTTGFLYSGAGDYSQMFDALEDDGSLEDLGGVGHASSTAAEKKRRLGVEQVKALEKNFEIDNKLEPERKVKLAQELGLQPRQVAIWFQNRRARWKTKQLERDYGVLKSNFDALKRNRDSLQRDNDSLLGQIKELKAKLNVEGVKGIEENGALKAVEANQSVMANNEVLELSHRSPSPPPHIPTDAPTSELAFEMFSIFPRTENFRDDPADSSDSSAVLNEEYSPNTVEAAGAVAATTVEMSTMGCFSQFVKMEEHEDLFSGEEACKLFADNEQWYCSDQWNS
Protein: H-2 class I histocompatibility antigen, L-D alpha chain (P01897)
Organism: Mus musculus (Mouse)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MGAMAPRTLLLLLAAALAPTQTRAGPHSMRYFETAVSRPGLGEPRYISVGYVDNKEFVRFDSDAENPRYEPQAPWMEQEGPEYWERITQIAKGQEQWFRVNLRTLLGYYNQSAGGTHTLQWMYGCDVGSDGRLLRGYEQFAYDGCDYIALNEDLKTWTAADMAAQITRRKWEQAGAAEYYRAYLEGECVEWLHRYLKNGNATLLRTDSPKAHVTHHPRSKGEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVYHEGLPEPLTLRWEPPPSTDSYMVIVAVLGVLGAMAIIGAVVAFVMKRRRNTGGKGGDYALAPGSQSSEMSLRDCKA
Protein: Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (P79996)
Organism: Gallus gallus (Chicken)
Function: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity).
Interaction partners:
- mitogen-activated protein kinase kinase
- Transcription factor Jun
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase.
- Mitogen-activated protein kinase kinase 7.
- Transcription factor JunD
- Nuclear factor of activated T cells 3
- Protein c-Fos
- Mitogen-activated protein kinase 8 interacting protein 2.
- Dual specificity protein phosphatase 10
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESDRDKLKTSQARDLLSKMLVVDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSAQMQQ
Protein: Uncharacterized helicase C15C4.05 (EC 3.6.4.-) (O60114)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- ATP-dependent RNA helicase ded1
- ATP-dependent RNA helicase eIF4A
- Eukaryotic translation initiation factor 5B
- AP-2 complex subunit mu
- Probable eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 4 gamma
- AP-1 complex subunit beta-1
- AP-2 complex subunit beta
Sequence:
MAKKKSKASNSARGYATTSIPSRSASSPANKNQVKGEKNNKTQKVEPKNAFKVENQSNDIGVDTVDAFDHLLLDKTLPTIDAETEVIKNTSLSNSKSFLHSWQTDIRLRKNDNVLGLTEDEIQQILKTFRDSWKSSLKESYAFSNRSSFSLRKRYLWTTFLSLKGMGFEESEIFGAFSSIPIVSIDEYITWMITENLINSEPSNSSFSYEVQPSNYTTFCRMLDEPLPANNPVQSNSRLVPLMKDFSNDIKHTPNKETQPSNQVDDSLKSKDSKPLTMSEVLTQLPEDDIPFDDPFDLTSQYVKVKLKMLRLQIANKKNSEEFSTLNLQLESITSQYLFSSKEAEIVFRKSRIEFMNKLKALQQKLENERIVEEIKKNGIQEDSQSTDDSSKDDDNNSESNDMSPHNDAETRADDDAYLMGDLFNQEEEDIQDTENDLLNANYTLLPLTTDKSGTRPSTTLQYELHKIGSNIKAEFKTMPIGKIGYQSTCFVRCSTGQKTFSDLKTVLPTATLAADYISMIVLFRLMANFTKISLQTFPKSFKEVYGKFSAEKQNTDLAEDAKISEKLDSIIKSKELETPTSATTSKLMAPMDNIGKFSGFERPPETLLNKWRQQLESESAEKFKVFRNQLPATMFRETIIDAVNNSQLLIISGDTGCGKSTQIPAFLLENSTKNGKAVKIYVTEPRRISAISLANRVSQELGGNPPSARSHELVGYSVRLDSKCTPLTPLTYVTTGTFLRLLEVGNEIESVTHLIIDEVHERSIDSDLLLIHVLHLLKQHPHLKIIIMSATLNAEKFQLYFEGSNLITIPGKTYPVHRFYLEDILSQFGNDKSFGNAAGQDVIEEDDYETDQQDASISNKSAEDAIVEMNLIPAWYNEKAINYGLIVYLLKYIFTEGDPKFSKCVLVFLPGISEILRVKSLIEDMPMFRNHRKFCIYMLHSTLSSAQQQSVFNIPPKGCRKIVLSTNIAETGVTIPDVTCVIDTGVHREMRYNSRRHLSRLTDTFVSKANAKQRSGRAGRVQEGICYHLFSKFKHDTQFLSYQTPEILRLNLQEVVLRVKMCQMGDVQDVLGKALDPPSSTNIIRALEKLHQVGALSENEKLTKLGKFLSQLPVDANLGKILVLGCFYKCVDAASSIVAMLTIGSPFRKSVDNEFSANKARLSFAKENTRSDLVLMYYAYCAWREICLSPLGPDEDSFAKEKYLNLEALSMTESLKIQLLSELKDMKLLGASDVDTCKSLKRSICRRFAVIPKEHDINSGNAEILCGVIAASLYPNILRYDYEKRQWSTLSTNKRVRILDVSVNNRSELPNMPSKFVAYTNMMSSTRASEYVNETTMVTLRQLLMMCGLKVENRVSVGQAKLDNFTVYFENVYVSASLSILRRFIETSLNEFFAEPDKRLLNSHLEVIVNIVSRLNYGTKFQKRLKD
Protein: Protein RAFTIN 1B (TaRAFTIN1b) (BURP domain-containing protein 1B) (Q70KG3)
Organism: Triticum aestivum (Wheat)
Function: Required for pollen development. Probably synthesized in the tapetum, packaged in Ubisch bodies and transported at appropriate stages to the micropsores.
Interaction partners:
- RING-type E3 ubiquitin transferase
- RING-type E3 ubiquitin transferase
- RING-type E3 ubiquitin transferase
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase
Sequence:
MARFLVALLAATLVAVQAGGQLGHAAPATGEVFWRAVLPHSPLPDAVLRLLKQPAAESTSFVRDPEDRPPFDYRDYSRSSSDDEPSKSTVAASGAGGFDYDNYSGADERRGATDEYKAPSSSLAGSGAYMARGGKAETTTVFFHEEAVRVGRRLPFHFPPATPAALGFLPRQVADSVPFTTAALPGILATFGIASDSTTVPSMEATLRACESPTIAGESKFCATSLEALVERAMGVLGTRDIRPVTSTLPRAGAPLQTYTVVAVQPVEGGPVFVACHDEAYPYTVYRCHTTGPSRAYTVDMEGARGADAVTIAAVCHTDTSLWNPEHVSFKLLGTKPGGTPVCHLMPYGHIIWAKNVKRSPA
Protein: (-)-beta-phellandrene synthase 1, chloroplastic (EC 4.2.3.52) (Terpene synthase TPS-Phel-1) (PsTPS-Phel-1) (F2XFA4)
Organism: Picea sitchensis (Sitka spruce) (Pinus sitchensis)
Function: Terpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (-)-beta-phellandrene.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MAIVSSVPLASKSCLHKSLISSIHKLKPFCRTIPTLGMSRPGKYVMPSMSMSSPVSDDGVQRRTGGYHSNLWNDDIIQFLSTPYGEPAYRERGERLIDEVKNMFNSISMEDVEFSPLNDLIQRLWIVDSVERLGIDRHFKNEIKSTLDYVYSYWTQKGIGCGIESVVPDLNSTALGLRTLRLHGYPVSAEVLKHFQNQNGQFACSPSETEGEMRSIVNLYRASLIAFPGEKVMEEAEIFSTKYLKEALQKIPVSSLSREIGDVLEQDWHTNLPRLEARNYIDVFGQDTKDTKLYMKTEKLLELAKLEFNIFQSLQKTELDSLLRWWKDSGFPHITFSRHLHVEYYTLASCIAFEPQHSRFRLGFAKACHVITILDDMYDVFGTIDELELFTAQIKRWDPSATDCLPKYMKRMYMILYDMVNEMSREAETAQGRDTLNYARQAWEDFIDSYMQEAKWIATGYLPTFDEYFENGKVSSGHRVAALQPILTMDIPFPHDILKEVDFPSKLNDLASAILRLRGDTRCYKADRARGEEASCISCYMKDNPGATEEDALSHINAVISDVIKGLNWELLNPNSSVPISSKKHVFDVSRALHYGYKYRDGYSVSNIETKSLVMRTLLESVPF
Protein: Cytochrome P450 86A7 (EC 1.14.14.1) (Q9CAD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the omega-hydroxylation of various fatty acids (FA). Acts on saturated and unsaturated fatty acids with chain lengths from C12 to C18.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein HOTHEAD
- Acyl-CoA hydrolase 2
- Acyl-CoA thioesterase family protein.
- Fatty alcohol:caffeoyl-CoA acyltransferase
- Omega-hydroxypalmitate O-feruloyl transferase
- F21B7.2
- At3g10570
- Very-long-chain enoyl-CoA reductase
- GDSL esterase/lipase At1g58430
- Transmembrane protein
Sequence:
MDGSTAAIILTLIVTYIIWFVSLRRSYKGPRVWPLVGSLPALITNAHRMHDFIADNLRMCGGTYQTCIFPIPFLAKKQGHVTVTCDPKNLEHILKTRFDNYPKGPSWQSVFHDLLGDGIFNSDGDTWRFQRKTAALEFTTRTLRQAMARWVDRAIKNRLVPILESARSRAEPIDLQDVLLRLTFDNICGLTFGKDPRTLSPEFPENGFAVAFDGATEATLQRFIMPEFIWKIRKWLRLGLEDDMSRSISHVDNYLSEIINTRKLELLGQQQDESRHDDLLSRFMKKKESYSDKYLKYVALNFILAGRDTSSVAMSWFFWLVSLNPRVEEKIINEICTILIKTRDTNVSKWTDEPLTFDEIDQLVYLKAALSETLRLYPSVPEDSKFVVANDVLPDGTFVPSGSNVTYSIYSVGRMKFIWGEDCLEFKPERWLEESRDEKCNQYKFVAFNAGPRICLGKDLAYLQMKSITASILLRHRLTVAPGHRVEQKMSLTLFMKFGLKMDVHKRDLTLPVEKVVNEMRKK
Protein: Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86) (D3ZGS3)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling.
Subcellular location: Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q01968}. Early endosome membrane {ECO:0000250|UniProtKB:Q01968}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q01968}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q01968}. Cell projection, cilium {ECO:0000250|UniProtKB:Q01968}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19795375}. Endosome {ECO:0000269|PubMed:19795375}. Cytoplasmic vesicle {ECO:0000269|PubMed:19795375}. Note=Also found on macropinosomes. {ECO:0000250|UniProtKB:Q01968}.
Interaction partners:
- Phosphatidylinositol-3-phosphatase SAC1
- Ras-related protein Rab-8A
- Inositol polyphosphate-4-phosphatase type I A
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
- Synaptojanin-1
- Type II inositol 3,4-bisphosphate 4-phosphatase
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Synaptojanin-2
Sequence:
MEPRLPIGAQPLACLHMVAGLEMKGPLREPCVLTLARRNGQYELIIQLHGKEQHVQDIIPINSHFRCVQEAEETLLIDIASNSGCKIRVQGDWTRERHFEIPDEERCLKFLSEVLAAQEAQSQLLVPEQKDSSNWYQKLDTKDKPAYSGLLGFEDNFSSMNLDKKMNTQNPPTGIHREPPPPPSSNRMLPREKEALNKEQPKVTNTMRKLFAPNSQSGQREGLIKHILAKREKEYVNIQSFRFFVGTWNVNGQSPDSSLEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWAMAVERGLPSKAKYKKVQLVRLVGMMLLVFAKKDQCQYIRDIATETVGTGIMGKMGNKGGVAMRFVFHNTTFCIVNSHLAAHVEEFERRNQDYKDICARMSFSVPNQTLPQVNIMKHDVVIWLGDLNYRLCMPDANEVKSLINKNELQKLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGINVNQLHYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDIVRIMDRMENDFLPSLDLSRREFMFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDTQYCKPWLRAEPFEGYLEPNETIDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDLEEDSFLEKEKSLLQMVPLDEGTSERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVAEALLIFLEALPEPVICYELYQRCLDSAHDPRICKQVISQLPRCHRNVFRYLMAFLRELLKFSDYNNVSTNMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLVFLLGSEED
Protein: Transmembrane protein (Q385T1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSGRIYKLFTGREQPQWMWDLALETRIPALFMAYAVYVNTRCYYDALSSYKANSKWGITRGKLLELRRLDYRYISVPRYALRYEYEVDGKKYVSTRATTGSPYRNWMERFYNDTITESEYLQAIPVLRVGENCTVFYSKKHPGVHSALAHDANSFEISILCFLAVFPLLMGYNMKAQWWMIKRAYRPNKMLRIRFPPNCRTPPPPEAPSSPCHISAIPKS
Protein: Extender of the chronological lifespan protein 1 (C6Y4D3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in chronological cell aging. Extends cell viability after entry into the stationary phase probably through affecting the Pka1-dependent pathway negatively.
Subcellular location: Nucleus {ECO:0000269|PubMed:18422613}.
Interaction partners:
- Extender of the chronological lifespan protein ecl3
- Hydrogen peroxide stress regulator 1
- Protein lsd90
Sequence:
MDLDFCTVCGATTQDGSLYCSSECHLLDFTKLDTQTTSNISVSSEYQFLVSEHLAHFHRKSMTSADFPTPRFSAYTKLHA
Protein: Divalent-cation tolerance protein CutA (C-type cytochrome biogenesis protein CycY) (P69488)
Organism: Escherichia coli (strain K12)
Function: Involved in resistance toward heavy metals.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:7623666}.
Interaction partners:
- Thiol:disulfide interchange protein DsbD
- Tryptophan biosynthesis protein TrpCF
- Thiol:disulfide interchange protein DsbC
- Co-chaperonin GroES
- HTH-type transcriptional regulator YjdC
- PF03932 family protein CutC
- Chaperonin GroEL
Sequence:
MLDEKSSNTASVVVLCTAPDEATAQDLAAKVLAEKLAACATLIPGATSLYYWEGKLEQEYEVQMILKTTVSHQQALLECLKSHHPYQTPELLVLPVTHGDTDYLSWLNASLR
Protein: Uncharacterized protein (O33271)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Putative S-adenosyl-L-methionine-dependent methyltransferase Rv3767c
- Phosphoribosylformylglycinamidine synthase subunit PurS
- Probable short-chain type dehydrogenase/reductase
- Putative ribonuclease VapC34
- Putative antitoxin VapB34
Sequence:
MSALLDGVLDAHGGLQRWRAAETVHGRVRTGGLLLRTRVPGNRFADYRITVHVQQARTVLDPFPRDGYRGVFESGQVRIESHDGAVISSRAHPRAAFFGRSGLRRNIRWDPLDSVYFAGYAMWNYLTTPYLLTREGVAVEEGAPWQQEGETWRRLIVSFPPDIDTHSPRQTFYVDASGLLRRHDYVPEVVGHWARAAHYCADPVDVDGFVFPTCRWVHPIGPGNRSLPFPTLVSILLTDIRVETD
Protein: Geranylgeranyl diphosphate synthase (Q9RUJ1)
Organism: Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
Interaction partners:
- Phytoene synthase
- Isoprenyl transferase
- Polyprenyl synthase
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
- Isopentenyl-diphosphate delta-isomerase
- N-acetyltransferase domain-containing protein
Sequence:
MRPELLARVLSLLPETSATPELARFYALLRDYPQRGGKGIRSELLLASARAHGLSESDTGWESALWLAAALELFQNWVLVHDDIEDDSEERRGRPALHHLCGMPVALNVGDALHAYMWAAVGKANVPGAFEEFLQMVYRTAEGQHLDLAWVEGREWGLRPADYLQMVGLKTAHYTVIVPLRLGALAAGMAPQDAFTPAGLALGTAFQIRDDVLNLAGDPVKYGKEIGGDLLEGKRTLIVLDWLTTAPDDRKAIFLDQMRRHRADKDPAVIDEIHRWLLESGSVEAAQDYAQAQAAEGLDLLEKALADAPDAQAAAALLASVRELATREK
Protein: Sodium/potassium-transporting ATPase subunit beta (Q90Z34)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}. Membrane {ECO:0000256|RuleBase:RU362099}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit alpha.
- Sodium/potassium-transporting ATPase subunit alpha
- Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b.
- Calcium-transporting ATPase
- Sodium/potassium-transporting ATPase subunit alpha.
- FXYD domain-containing ion transport regulator
- Sodium/potassium-transporting ATPase subunit alpha
Sequence:
MAKDDKNGWKEFFWNPRTREFCGRTASSWGLILLFYLAFYIFLAGLFTLTMYVMLQTLDDHRPTYQDRLSTPGMMIRPKGEQLEIAYTTEYTETWERYVQALNNFLSPYNDTVQTQKNYECKPDQFFIQEDSGGLKNFPKRSCQFKRSILEKCSGITDRFYGYDEGKPCIIIKLNRVIGLLPAKDGQPPYVTCGAKKYKVGKDEWTDDSDKLGELAYYPPNGTFNLMYYPYYGKKAQVNYSQPLVAVKFLNITRNEDVNVECKINSNNIPEGSERDKFAGRVSFTLRINSRD
Protein: CG6459 protein (CG6459-PA) (LD29590p) (P32) (Q7JXC4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Prohibitin
- La protein homolog
- GH11850p
- GEO09167p1
- Prohibitin 1
Sequence:
MNSLRTATMRFAALASSSAGSLGKRDFTRSLWHMTKKPVTAGGSDHVTVLNLHKPSINCTCGCNVHTKCERELVEFLTEEIVAERKVQKGKTVPSTLDGFAVKLTGADVELTKQTDKEKVVVSFNVNHTVDSEEEPEINPNADKPDLGEMRSKPQFEVDIIKGNSTLSFTCSFLQGEAQEGEYNDVFSIDEMAIFEGEWNDKVYAVAGDVLDGYLYDLLINLLEEKGISQEFAEKLSDLATAHEHTSYIGLLEKLSKFTAGGK
Protein: Adenylate kinase, putative (EC 2.7.4.3) (Q38B28)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Adenylosuccinate lyase
- Adenosine kinase
- Adenosine kinase
- adenine phosphoribosyltransferase
- adenine phosphoribosyltransferase
- Pyruvate kinase
- Phosphodiesterase
Sequence:
MGLHILLFGAPGCGKGTASEFLVRRYDFIHVSTGNLLREEVKKGSAIGRQVEGLMSEGQLIPDHVVVAMIINRLQRPDTKGRGILLDGFPRTRAQAETLAANGFKVDAMIFIDVDEIKLEERCVFRRLDPVTGRIYNLKSDPSPQEIMGRLLIRSDDNREKHRRRMQVYLKQKASLMEYYRGKVLEVDGNPPLPVVLKSVATKVDELLRIEKSKL
Protein: E3 ubiquitin-protein ligase RNF187 (EC 2.3.2.27) (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187) (RING-type E3 ubiquitin transferase RNF187) (Q8BFX1)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q5TA31}. Nucleus {ECO:0000250|UniProtKB:Q5TA31}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250|UniProtKB:Q5TA31}.
Interaction partners:
Sequence:
MALPAGPADAICALCQRAPREPVRADCGHRFCRACVVRFWAEEDGPFPCPECADDCWQRAVEPSRPPLSRRLLALEEAAAAPARDGPASEAALQLLCRADGDPLCSACRMAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKDEGASEDDELADPADRFRSLLQAVSELEKKHRNLGLSMLLQ
Protein: Probable transcriptional regulator (G3XCU9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Resistance-Nodulation-Cell Division
- Probable binding-protein-dependent maltose/mannitol transport protein
- Efflux pump membrane transporter
- Probable porin
- Probable transcriptional regulator
Sequence:
MARKTKEESQKTRDGILDAAERVFLEKGVGTTAMADLADAAGVSRGAVYGHYKNKIEVCLAMCDRAFGQIEVPDENARVPALDILLRAGMGFLRQCCEPGSVQRVLEILYLKCERSDENEPLLRRRELLEKQGQRFGLRQIRRAVERGELPARLDVELASIYLQSLWDGICGTLAWTERLRDDPWNRAERMFRAGLDSLRSSPYLLLADA
Protein: Putative pumilio homolog 10 (APUM-10) (AtPUM10) (Q9LP21)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20214804}.
Interaction partners:
- Pumilio homolog 24
- Probable apyrase 7
- MEI2 C-terminal RRM only like 2
- Putative pumilio homolog 25
- Pumilio homolog 23
- Pumilio homolog 26
- F-box protein At1g61340
- Zinc finger CCCH domain-containing protein 49
Sequence:
MEIFNFGQASDHRRLPDFGSGGFLQSLDTNPFLKNQYYNNSVEALELCKKLNKMGISCDMSIWTKPEEPFRVDPGDFGAKTLHESFGFDQNLTGASQIHDGFRNFSSVRVQNNNFHGVSPSPGLLGLQDSFNPNGFEEMMAFKDHKDFLLDHINEPIKRSPFLRGNDAFKGSLMFEGIRVSQILAAMEGSGASYPDEPKINGGLPLDLVSMVEIYGSVNLMARDQIGCRALQKLVEEGTVLDSKVIFLEIIDHVVELSMDPLGNYIVQKLLVVSDEEQRTMIVSVLTSKPRELIKICLNTNGTRVIQKMIKTVKTKQQIALVKSALEPGFLVLVNDSNGYHVLQSCLEFLVPNDNKFVVEAATEYCAQLATHQYGCYVLQCSLINTVGLQHERLVAEISRDSLRLSQDPFGNYVVQCLIDQQVSSVNLLLPFRTHCIELATQKFSSHVIEKCLRKYPESRAEIVRELLSYPNFEQLLQDPYANYVIQTALSVTKGAVRARLVEKVKRFGKLQSNPYCKKIFSKTILKK
Protein: Bacterial microcompartment shell protein PduT (Bacterial microcompartment protein homotrimer) (BMC-T) (Propanediol utilization protein PduT) (Q9XDM8)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: A minor shell protein of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2. Not required for structural integrity of BMCs nor to mitigate propionaldehyde toxicity, may selectively transport specific metabolites. May be involved in electron transport across the BMC shell (Probable). Can be engineered to alter permeability of the BMC shell.
Subcellular location: Bacterial microcompartment {ECO:0000269|PubMed:12923081}.
Interaction partners:
- Bacterial microcompartment shell protein PduK
- Bacterial microcompartment shell vertex protein PduN
- Bacterial microcompartment shell protein PduU
- Bacterial microcompartment shell protein PduJ
- Cobalamin reductase PduS
- Bacterial microcompartment shell protein PduA
- Propanediol utilization protein PduV
- Bacterial microcompartment shell protein PduB
- Propanal dehydrogenase
- Corrinoid adenosyltransferase PduO
Sequence:
MSQAIGILELTSIAKGMELGDAMLKSANVDLLVSKTICPGKFLLMLGGDIGAIQQAIETGTSQAGEMLVDSLVLANIHPSVLPAISGLNSVDKRQAVGIVETWSVAACISAADRAVKGSNVTLVRVHMAFGIGGKCYMVVAGDVSDVNNAVTVASESAGEKGLLVYRSVIPRPHEAMWRQMVEG
Protein: Protein smoothened (P97698)
Organism: Rattus norvegicus (Rat)
Function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P56726}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium {ECO:0000250|UniProtKB:P56726}. Note=Cilium localization is promoted by SHH and is required for activity. {ECO:0000250|UniProtKB:P56726}.
Interaction partners:
- Patched
- Sonic hedgehog protein
- Suppressor of fused homolog
- Hedgehog protein
- Patched 2
- Beta-arrestin-2
- GLI family zinc finger 1
- Beta-arrestin-1
- Kinesin-like protein
- EvC ciliary complex subunit 2
Sequence:
MAAGRPVRGPELAPRRLLQLLLLVLLGGRGRGAALSGNVTGPGPRSAGGSARRNAPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHSKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGLAFELNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANLWLVEAEISPELEKRLGRKKKRRKRKKEVCPLGPAPELHHSAPVPATSAVPRLPQLPRQKCLVAANAWGTGEPCRQGAWTVVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLMEAELLDADSDF
Protein: BcDNA.GH02435 (F box/ubiquitin conjugase) (Modifier of rpr and grim, ubiquitously expressed) (Q9Y165)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- E1 ubiquitin-activating enzyme
- Death-associated inhibitor of apoptosis 1
- Ubiquitin-ribosomal protein eL40 fusion protein
- GEO01111p1
- Ubiquitin-ribosomal protein eS31 fusion protein
- E3 ubiquitin-protein ligase CHIP
- GH17761p
- Polyubiquitin
- Ubiquitin thioesterase otubain-like
- RT03845p
Sequence:
MTSCVPAHQQKDQEQLLKELASSGDEMDDPDDPDQEHHQLVEPTFSFSNSNTCWVCNGYYGPNFGEPLCGACHAFLYNAQRAEELLTELSDDEDSGNDEPPFKDKQEDEETENDVDIMGFEDLEDPQPAAVPQHPNPQPPMEPQDQQPAQPVIDLPQPVPEAAAPRRESPERDFEHERAINPFLLPIKRPRATAPLALPHYMHELADGRARVHEYNAASGSGASGSSRNIVNIIPVEVMLKIFAYLDDMSLWMASEVCKQWHDIVGKNTAQSMWKAYIKQRWPLFDSLADNPNWYRLYGALMSSCFCRTCLIEMGGRGQDAQEADPQLGDREPGNVMRNNFLRGEANLLNSYESEGISAIPLDRQNNYWQATILGPPGSPYEGGKFFLFIYFPERYPMTPPTVRFLTKILHPNVSRHGDVGIDIFQQHNWSLALNVAKVLLSVQSLLTDPYTEVCMEPELGYIYEHERERFEQLVRAWTWKYAMYELIAPR