wanglab/gogpt-training-data huggingface dataset:
Protein: Bifunctional TH2 protein, mitochondrial (THIAMINE REQUIRING 2) [Includes: Thiamine phosphate phosphatase (EC 3.1.3.100); Aminopyrimidine aminohydrolase (EC 3.5.99.2)] (F4KFT7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the salvage of thiamine breakdown products. This protein has a haloacid dehalogenase family domain fused to its TenA domain. Phosphatase with the highest activity against thiamine monophosphate (ThMP) and, with a lower activity, against thiamine diphosphate (ThDP), flavin mononucleotide, inorganic pyrophosphate, CTP and dATP. Has a thiamine salvage hydrolase activity, but only against 4-amino-5-aminomethyl-2-methylpyrimidine (amino-HMP) and not against N-formylamino-HMP, desthiothiamine, thiamine, ThMP, and ThDP.
Subcellular location: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:27677881}. Cytoplasm {ECO:0000269|PubMed:27677881}. Note=Localized to the mitochondrion when the first start codon is preceded by a strong Kozak sequence. {ECO:0000269|PubMed:27677881}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:27677881}.
Interaction partners:
- Phosphomethylpyrimidine synthase, chloroplastic
- Thiamine biosynthetic bifunctional enzyme TH1
- Thiamine pyrophosphokinase 1
- Thiamine pyrophosphokinase 2
- Thiamine thiazole synthase, chloroplastic
- Bifunctional TENA-E protein
- At5g66005
- Small ribosomal subunit biogenesis GTPase RsgA 1, mitochondrial
- Hydroxyethylthiazole kinase
- Purine-uracil permease NCS1
Sequence:
MRFLFPTRLINNSSLGLLRSPHTTAPIRSLWFRTKSPVFRSATTPIMTAVAFSSSLSIPPTSEEALPGKLWIKFNRECLFSIYSPFAVCLAAGNLKIDTFRQYIAQDVHFLKAFAHAYELAADCADDDDDKLAISDLRKSVMEELKMHDSFVQDWDLDINKEVSVNSATLRYTEFLLATASGKVEGCKAPGMLDTPFEKTKVAAYTLGAVTPCMRLYAFLGKEFGSLLDLSDVNHPYKKWIDNYSSDAFQASAKQTEDLLEKLSVSMTGEELDIIEKLYQQAMKLEVEFFHAQPLAQPTIVPLLKNHSKDDLVIFSDFDLTCTVVDSSAILAEIAIVTAPKDEQSRSGQQIHRMLSSDLKNTWNLLSKQYTEHYEECIESILNKKKADKFDYEGLCKALEQLSDFEKEANNRVIESGVLKGLNLEDIKRAGERLILQDGCINVFQKILKTENLNAELHVLSYCWCGDLIRAAFSAGGVDAVEVHANEFTFEESISTGEIERKVESPINKAQQFKSILQNRKNENNKKSFLSVYIGDSVGDLLCLLEADIGIVVSSSSSLRRVGSHFGVSFVPLFSGIVQKQKQHTEESSSSAWKGLSGTLYTVSSWAEIHSFALGWE
Protein: AT-rich interaction domain 1B (H0Y2R3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPVVQMEPRACDTGGSGRKASWSRPAPRARAGGSRHTQASGGRRQRHPGLQKPLDSLPPTQQVASPIPVPSLGKVSGNIFVVKGK
Protein: Uncharacterized protein (Q57Y79)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHRRTFFLFLFSKPLTQGYVAQLPQPAPTAQRTAWRRCFETNKEVQDMYTPNAERYDEWYRETYGLEDISDGCAASGASSNRLLNDDKNLSETADVEDLRAAEEEVEWCSRQFNHNTLVR
Protein: UNC-76 (E0AHC4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTNSDDEDLLRQQMDVHQMIGHHHGSTDTGGETPPQTADQVIEEIDEMLQSCDFTGSMMTDRTMESVDSMYSSMRSPFPSSIQSSDADIKLRSAQALVSNPDNLQELSYSKLVTLCAEMEQLIRVYNESLVDELAHRDELDYEKEMKNSFISLLLAIQNKRRVYANDRKRKVGKASDASQLPQYLTATIPYNDHQHIDNASIASLIKILRAIHDDNTTVPTLLTDYILTHVCPKNISC
Protein: Long-chain fatty acid transport protein 2 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Phytanate--CoA ligase) (EC 6.2.1.24) (Solute carrier family 27 member 2) (THCA-CoA ligase) (EC 6.2.1.7) (Very long-chain acyl-CoA synthetase) (VLACS) (VLCS) (EC 6.2.1.-) (Very long-chain-fatty-acid-CoA ligase) (P97524)
Organism: Rattus norvegicus (Rat)
Function: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (By similarity). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (By similarity). May contribute to the synthesis of sphingosine-1-phosphate (By similarity). Does not activate C24 bile acids, cholate and chenodeoxycholate. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. However, it is not critical for THCA activation and bile synthesis in vivo (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10640429}; Multi-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:10640429, ECO:0000269|PubMed:8939997}; Peripheral membrane protein {ECO:0000269|PubMed:10640429}. Cell membrane {ECO:0000250|UniProtKB:O35488}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000269|PubMed:10640429, ECO:0000269|PubMed:8939997}.
Interaction partners:
- Long-chain-fatty-acid--CoA ligase 1
- Peroxisomal acyl-coenzyme A oxidase 1
- Serum amyloid P-component
- Zinc-alpha-2-glycoprotein
- Fructose-1,6-bisphosphatase 1
- Peroxisomal acyl-coenzyme A oxidase 2
- Cytochrome P450, family 4, subfamily a, polypeptide 2
- Platelet glycoprotein 4
- Peroxisomal bifunctional enzyme
Sequence:
MLPVLYTGLAGLLLLPLLLTCCCPYLLQDVRFFLQLANMARQVRSYRQRRPVRTILHVFLEQARKTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALFMGNEPAYVWLWLGLLKLGCPMACLNYNIRAKSLLHCFQCCGAKVLLASPELHEAVEEVLPTLKKEGVSVFYVSRTSNTNGVDTVLDKVDGVSADPIPESWRSEVTFTTPAVYIYTSGTTGLPKAATINHHRLWYGTSLALRSGIKAHDVIYTTMPLYHSAALMIGLHGCIVVGATFALRSKFSASQFWDDCRKYNATVIQYIGELLRYLCNTPQKPNDRDHKVKIALGNGLRGDVWREFIKRFGDIHIYEFYASTEGNIGFMNYPRKIGAVGRENYLQKKVVRHELIKYDVEKDEPVRDANGYCIKVPKGEVGLLICKITELTPFFGYAGGKTQTEKKKLRDVFKKGDVYFNSGDLLMIDRENFIYFHDRVGDTFRWKGENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGRIGMASIKMKENYEFNGKKLFQHISEYLPSYSRPRFLRIQDTIEITGTFKHRKVTLMEEGFNPSVIKDTLYFMDDTEKTYVPMTEDIYNAIIDKTLKL
Protein: Proteasome subunit beta type-2 (Q55DY7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit beta type-6
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-7
- Proteasome subunit beta type-1
Sequence:
METLLAFKVKGGVLCLADSSVNHSIVKMKDDEDKILEIDGHKLLLSAGEAGDRVQFTEYISKNIKLYSLRNSYPMSTPAAANFIRNELATSIRSHPYSINLILAGYDKEVEDGGTSLYYMDYLGSLQKLNFGCHGYASYFLLGLLDRHHKCDLSLEDGINLMHLCTTELKTRFLVSGKYTLKFVSSEGIKVLPFNAPQ
Protein: BRCA1 associated RING domain 1 (A0AVN2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHMDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
Protein: Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) (Q96AE4)
Organism: Homo sapiens (Human)
Function: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Poly
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
- Fructose-1,6-bisphosphatase 1
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Heterogeneous nuclear ribonucleoprotein F
- Myc proto-oncogene protein
- Serine/arginine-rich splicing factor 3
- Far upstream element-binding protein 2
- KH domain-containing, RNA-binding, signal transduction-associated protein 1
- Cellular tumor antigen p53
Sequence:
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLPPMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGGPVNPLGPPVPHGPHGVPGPHGPPGPPGPGTPMGPYNPAPYNPGPPGPAPHGPPAPYAPQGWGNAYPHWQQQAPPDPAKAGTDPNSAAWAAYYAHYYQQQAQPPPAAPAGAPTTTQTNGQGDQQNPAPAGQVDYTKAWEEYYKKMGQAVPAPTGAPPGGQPDYSAAWAEYYRQQAAYYAQTSPQGMPQHPPAPQGQ
Protein: MSP-300 (Q6YDA5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
RSKVDKLVEQQAKLNDTLRDKEQQVSKDLEEIEQVFRRISQLQDKLNALHEQLQSVHVYDEHIAQTEQLLITLNSQVQQAAEESKLLVAQTTAHYQAKQNQLPSDIAQEFTALELLAERVQVTMETKEKDFKRAKTVRTEYVDGVDEVQRWLLQAEVQVQERSLTPTQMKELLQRINHEITAIYERFTLVKTNGQLIIENCRNSEEKTLVQTTIDQLAASLAQVRGWLDEKKQAVGDSLDAWTRFMNLYQIVMSWASEKRNFIDQTIELRTLPEARNKLNDYVTAVKSIKPIVKHLSEMDKENWLGKQESQIAGFERDQKSHSKHKLEERQMELRAK
Protein: Glucosidase 2 subunit beta (Q9VJD1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glucosidase II subunit alpha
- IP01335p
- Uncharacterized protein, isoform C
Sequence:
MQSLQLSQVLLIPLLLALVATNVGSASEVPRPLGVPLAKASLYQPRAGENSWTCLDGSRTIPFSHINDDYCDCADGSDEPGTAACPQGQFHCVNKGHQPVNIPSSQVQDGICDCCDGSDESETVGCPNTCLELGAAAAVQRRNAAELHKRGAERRQEMITRGKQMRAEREARRLELDQRRKEQELLRAEKEQLKQTAEALEAEAIEIFKEQQREVDADTAQAEREPQQMRQEATLTFVRYDTNKDGFVEVTELMVDMNLDRDRNGVVTVEEAKYFLDERERVDLDAFVTLAWPRIKSLQMLAEGLFQPPQPEEVAQQPEVTTESIQPTPPKLSEEQAELAGDDDIEADEEGEEDQYDDEEPDVGVGEASPDAEEATPPNYDPETQRLIQQANEARNALEEVERSLREIQQEVNEIDDQNNKGYGLTEEWAVHDGQCYNFEDREYVYTLCPFDRASQKSRSGGPETTLGRWDKWSGEPKQYSQQKYTNGAACWNGPNRSAIINISCALEPKITAVSEPNRCEYYFEFETPAACDSEAFQSESENLHDEL
Protein: leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (Q9VZ82)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- Tyrosine--tRNA ligase
- Lysine--tRNA ligase
- Isoleucine--tRNA ligase, cytoplasmic
- Probable arginine--tRNA ligase, cytoplasmic
- Probable glutamine--tRNA ligase
- Tyrosine--tRNA ligase, mitochondrial
- Methionine--tRNA ligase, cytoplasmic
- Probable arginine--tRNA ligase, mitochondrial
- Phenylalanine--tRNA ligase beta subunit
Sequence:
MQALRRTRPWGAVYWNSWRRLLTQSCTRNDNPELTSDVKHRIEAHWREQLSGGQFNPKDSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQRMCGKNVFQPMGWDSFGLPAENAANQRGVEPASWTEQNIAQMKEQLKRLGCSFDWNHELSTCSPKYYKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLADEQVDANGCSWRSGAKVEKKLLRQWFIRTSAYAKQLLDGLEDPTLRDWRDIINLQRHWIGECDGYAFNLLTSASGLLRVWTTHPEHLKDPHAFLVLRSNHHLSKLKGADSLSAANPFAGTTMPVVFSDEVTFPPKSDVYLAAPSFRGEDKDLWDSYGLAFTSNGKDEESLSPANWEMLRKEVLQAATRLNVGGYRVSSKLKDWLISRQRYWGTPIPIVHCQKCGAVPVPEEQLPVSLPPKDSPKEAFLCDCPKCGEKDARRETDTMDTFVDSSWYYLRYLDAQNSERIFDTALTKKFMPVDLYIGGKEHAVLHLYYARFINHFLHSCGLSPTSEPFSRLLVQGMVMGRSFRVKGSGRYVPETEVEIVNAKKNQAVLKETKEPVVMTWEKMSKSKLNGVEPSDMFNEYGTDTTRLIILADVAPTSHRNWSSATFPGILNWQKRLWLTLQDFQQAREDQTASDVVPTSEEFLAEDAKLFDARNFYVKGATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHGKQFERALAAQIIMLAPMAPHFASELWSKFVAIPGRLNPASQELQWSEDVLAQRWPDIDPAYNLDLSIKVNGFENCVIKVQRTHLDKVTHSDALDIAFNTESVTSYLIDKKIRTTNFVLYPGIEAILNIYVDKAKMKQKPPTTDDAEAQPQA
Protein: Plexin-A4 (Q9HCM2)
Organism: Homo sapiens (Human)
Function: Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Neuropilin-1
- Semaphorin-3A
- Semaphorin-6A
- Neuropilin-2
- Rho-related GTP-binding protein Rho6
- Plexin-A1
- Semaphorin-6D
- Ras-related C3 botulinum toxin substrate 2
- Rho-related GTP-binding protein RhoD
- Tyrosine-protein kinase Fyn
Sequence:
MKAMPWNWTCLLSHLLMVGMGSSTLLTRQPAPLSQKQRSFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRFASEMKQCVRLTVHPNNISVSQYNVLLVLETYNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIITENGDHHVVQLQLKSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTHDPKTCSFQEGRVKLPEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKVHLYKCGAMRESCGLCLKADPDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCTNPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVFQYVEDPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINICEVLNATEMTCQAPALALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTYYPNPVFEAFGPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLLCESPNLIGRHKVMARVGGMEYSPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAYKRKSRESDLTLKRLQMQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLVLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDLEWRQGSGARMILQDEDITTKIENDWKRLNTLAHYQVPDGSVVALVSKQVTAYNAVNNSTVSRTSASKYENMIRYTGSPDSLRSRTPMITPDLESGVKMWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPLDHDDQCGKQKLAYKLEQVITLMSLDS
Protein: inositol-polyphosphate 5-phosphatase (EC 3.1.3.56) (B7Z0Q2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform C
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Kinase
- Kinase
- LD06095p
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
- Kinase
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase
- Multiple inositol polyphosphate phosphatase 1
Sequence:
MESAQEDASSTDVFLVTANVGSLFEDPERLLQLWLSEFLAKIAVAQPRFLALHLQEVGGKTYEKSMEYVQEFIRCLCDAPEMGDFTCVHIFMDEDFKSAEHFTALGSLYFVHKDVASLKIWNFLTHSWEESLQDVKDKHIYSGNIETIATKEKSKFPQHFFPECKWSRKGFMRTRWEINGTVIDLVNIHLFHDASNLAACENFPSVYCKTRRRALVHTIERFHLDEQNGTVPFFLFGDFNFRCDTEGVVKELTENLTPHRVQNVKNENDKIHYRNSTGNNVLTVGKKEFSHADHQLKFKEDWLKKFDRELEPLKDVLVEYPIKFVPSYPFEEDPEMPTDYMSTRCPAWCDRILMSPQVNEIIQSDDWTYGMIGEAVCMGDHKPVYLTVRLKPNKGTYRSCDCNYTNTYAKPNNISTSPLPAVKLKYCPYSNKLFEDIATSSKLIVDTEARNMYNSLKISQDAEASRTTSSNFPNISINIIDSDNICMCLCAHLSSNSLLQLDGCNRTGEAICPMCRNIIKRQPVAHRYKLLSKRLMISQDIIINRIDSQHLSTDSERQYEDPYTPESTESHSPYPEVTSSCTSTSSSSRSPFERRLATDRLATESKAGDSDISPCPEVRDLVAEKPARGTVTPGQLKSRLETLKRLSIKDEAQDEGEDAVDEAGAGGDVEHVGAVCPPNAAPMRPKRRSKVIPMCCTIN
Protein: MecKel-Gruber Syndrome (MKS) homolog (C8JQP7)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Meckelin
- C2 domain-containing protein
- B9 domain-containing protein 1
- MecKel-Gruber Syndrome
- NePHronoPhthisis
- TMEM
- ADP-ribosylation factor-like protein 6
- Intraflagellar transport protein 46 homolog
- Protein fantom
- B9 domain-containing protein 2
Sequence:
MISNVRSSLVYQILLSLQKTLSIVYFLVIFILYFYKGAILPYPRYVRVMEFFVIIPFIPIEYLRINWGSRGNLLESTAFLALSTVLSIPIIIILVYLEFFQNYVLFIEEIFTYVMGFFVILETLLSLVLTITFSSSGQPASG
Protein: Sphingoid long-chain base transporter RSB1 (Q08417)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16407254, ECO:0000305|PubMed:24146988}; Multi-pass membrane protein {ECO:0000269|PubMed:16407254}.
Interaction partners:
- Pleiotropic ABC efflux transporter of multiple drugs
- Oligomycin resistance ATP-dependent permease YOR1
Sequence:
MSNATNNTLGSLLPQLEAAANSNSLYGGMVPNLRFNITMIVIWGILLTIHVVQLLMRQYWFSIAFICTGILEVLGFIGRTWSHSNVADMDAFLLNMICLTIAPVFTMGGIYYQLAKLIEVYGHRFSLLPSPMAYSFIFICSDIVSLVVQAVGGGLCGVAVTDGTSTTTGNHVFIAGLAIQVASMAIFLMLWFHFLFRIYISVRWEHINSRPISLSLLKISQTEVDYLYREKFHFLRLEPKRWVFHYFNLAITVAVLTIFTRCCYRLAELVVGWDGYLITHEWYFIILDALMMAIATVTLTIFHPGFAFKGRSTSIPITPGHVDPETLPHTDDVEDILDTSDSKQFDIEKEEFQASMKYPISTFKQFMSKIANLFSSKKKAKL
Protein: Sycp3 like X-linked (D3Z347)
Organism: Mus musculus (Mouse)
Interaction partners:
- Spermiogenesis specific transcript on the Y 2
- Y-linked testis-specific protein 1
- 
- Predicted gene, 20852
- Predicted gene, 20806
- RIKEN cDNA 1700013H16 gene
Sequence:
MSIKKLWVIPKDGYLLLLDFDSDEEEEQAHSEVKRPAFGKHENMPPHVEADEDIRDEQDSMLDKSGENVSFSVEWQRFARSVETPMENWNLLSGEQQVRNASELDLMEVQNPVTHDDGNANPEVVVGDTRKKINNKLCEQKFDMDIQKFNEEQEKSVNNYQKEQQALKLFECSQSQTLEAIEDMHEKSMEGLMNMETNNYDMLFDVDGEETL
Protein: Sodium-dependent phosphate transport protein 3 (Na(+)/PI cotransporter 3) (Sodium/phosphate cotransporter 3) (Solute carrier family 17 member 2) (O00624)
Organism: Homo sapiens (Human)
Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q5SZA1}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Thyroxine-binding globulin
- Sodium-dependent phosphate transport protein 2A
Sequence:
MDGKPATRKGPDFCSLRYGLALIMHFSNFTMITQRVSLSIAIIAMVNTTQQQGLSNASTEGPVADAFNNSSISIKEFDTKASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPCISVREKEHILSSLAQQPSSPGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLRLITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGIISSTATGFLISQVGPVY
Protein: C-C motif chemokine 1 (P500) (SIS-epsilon) (Small-inducible cytokine A1) (T-cell activation protein 3) (TCA-3) (TCA3) (P10146)
Organism: Mus musculus (Mouse)
Function: Cytokine that is chemotactic for neutrophils.
Interaction partners:
- C-C chemokine receptor type 8
- C-C chemokine receptor type 5
- C-C chemokine receptor type 6
- C-C chemokine receptor type 1
- C-X-C motif chemokine 9
- Atypical chemokine receptor 4
- C-C chemokine receptor type 2
- C-X-C motif chemokine 10
- C-C chemokine receptor type 10
- Probable C-C chemokine receptor type 3
Sequence:
MKPTAMALMCLLLAAVWIQDVDSKSMLTVSNSCCLNTLKKELPLKFIQCYRKMGSSCPDPPAVVFRLNKGRESCASTNKTWVQNHLKKVNPC
Protein: Endochitinase At2g43610 (EC 3.2.1.14) (O22842)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RING-type E3 ubiquitin transferase
- Regulator of Vps4 activity in the MVB pathway protein
- Regulator of Vps4 activity in the MVB pathway protein
- Regulator of Vps4 activity in the MVB pathway protein
- Regulator of Vps4 activity in the MVB pathway protein
- At1g25420/F2J7_16
- Regulator of Vps4 activity in the MVB pathway protein
- Regulator of Vps4 activity in the MVB pathway protein
- Regulator of Vps4 activity in the MVB pathway protein
- Regulator of Vps4 activity in the MVB pathway protein
Sequence:
MATQNAILKKALIIFLFTLTIMTGTAFSQNCGTNGCKGNMCCSRWGYCGTTKAYCGTGCQSGPCNSKPKPTPTPSGSGGLNAGPRGTIASVITPAFFNSIMSKVGSGCPAKGFYTRQAFIAAAESFAAYKGTVAKREIAAMLAQFSHESGSFCYKEEIARGRYCSPSTTYPCQPGKNYYGRGPIQITWNYNYGAAGKFLGLPLLKDPDMVARSPTVAFQCAMWFWNKNVRPVLSQGFGATTRRINGGECNGGRPAAVQSRVNHYLDFCKKLGVTPGTNLSC
Protein: CDGSH iron-sulfur domain-containing protein, putative (Q9NDU7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- CPSF, subunit A, putative
Sequence:
MKDPLEYLNKINFNTNKFPQYTHLIENCPSEYENEKVIRICRCWQSAKFPYCDDTHKIFVENGDNVGPYVAKLVSYKLSDEEKLKKQKYNEKYIKLNNKMSYIKSENFNFKWFPTPIINYKFKKYVLLSFFVLTSSVLYTKKEKLYNFNTES
Protein: Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (Initiation factor five protein 1) (P34563)
Organism: Caenorhabditis elegans
Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity). Required for mitotic germ cell proliferation, gametogenesis after entry into meiosis, and localization of the P granule component pgl-1 on P granules.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P23301}.
Interaction partners:
- Ubiquitin-like domain-containing protein
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS17
- Deoxyhypusine synthase
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL29
- Small ribosomal subunit protein eS1
Sequence:
MSEDHHDEEQFDSAESGAAATFPKQCSALRKNEHVMIRGRPCKIVEMSTSKTGKHGHAKVHMVAIDIFTTKKLEDICPSTHNMDVPVVKRREYILMSIEDGFCSLMDPESCELKDDLKMPEGDLGNTIREALEKDEGSVLVQVVAACGEEAILGYKISTKE
Protein: Oxysterol-binding protein (O18397)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTDAAGNALAEKGLPEMKGWLLKWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGALIHTVDSCTFVISNGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAIECEEEEETETAHVVPSQEISSVVRDLTDRLESMRTCYDLITKHGAALQRALNDLETNEEESLGSRTKIVNERATLFRITSNAMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQMAKQQSQMEQAAVLVRQNKPVSSTSGAGTAGSLVTSDEEMEFFDAEEHGYSGSGRSPESSDCERGTFILKMHKRRSSSEDQVEGHLEGSSSESDEQKRTVQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWNPDLIKKRRDRVPDKPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAGTVSAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSVSSPTYTTGEFKLAWRRRPAPPDSDKFYNFTTLACQLNEEEEGVAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERRRRENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNFEGCPDIY