wanglab/gogpt-training-data huggingface dataset:
Protein: Glutamate-gated chloride channel subunit beta (Glu-Cl subunit beta) (Avermectin-sensitive glutamate-gated chloride channel subunit) (Q17328)
Organism: Caenorhabditis elegans
Function: Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc-2 are activated by glutamate, but not by ivermectin (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q94900}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q94900}. Cell membrane {ECO:0000255, ECO:0000269|PubMed:7935817}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:7935817}.
Interaction partners:
- Tubulin beta chain
Sequence:
MTTPSSFSILLLLLLMPVVTNGEYSMQSEQEILNALLKNYDMRVRPPPANSSTEGAVNVRVNIMIRMLSKIDVVNMEYSIQLTFREQWIDPRLAYENLGFYNPPAFLTVPHVKKSLWIPDTFFPTEKAAHRHLIDMENMFLRIYPDGKILYSSRISLTSSCPMRLQLYPLDYQSCNFDLVSYAHTMNDIMYEWDPSTPVQLKPGVGSDLPNFILKNYTTNADCTSHTNTGSYGCLRMQLLFKRQFSYYLVQLYAPTTMIVIVSWVSFWIDLHSTAGRVALGVTTLLTMTTMQSAINAKLPPVSYVKVVDVWLGACQTFVFGALLEYAFVSYQDSVRQNDRSREKAARKAQRRREKLEMVDAEVYQPPCTCHTFEARETFRDKVRRYFTKPDYLPAKIDFYARFVVPLAFLAFNVIYWVSCLIMSANASTPESLV
Protein: E3 ubiquitin-protein ligase RMD5 (EC 2.3.2.27) (GID complex catalytic subunit 2) (Glucose-induced degradation protein 2) (Required for meiotic nuclear division protein 5) (Sporulation protein RMD5) (Q12508)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: E3 ubiquitin-protein ligase component of the GID complex. Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12686616}.
Interaction partners:
- GID complex subunit 8
- GID complex subunit 1
- GID complex subunit 9
- GID complex subunit 7
- GID complex subunit 5
- GID complex substrate-recognition subunit 4
- GID complex substrate-recognition subunit 10
- Protein yippee-like MOH1
- Ubiquitin-conjugating enzyme E2-24 kDa
- Fructose-1,6-bisphosphatase
Sequence:
MSELLDSFETEFAKFYTDSNLEETNLQKCLDHTHEFKSQLKKLKAHLNKHIQESKPEVYNKLSDKEKQKFKRKRELIIEKLSKSQRQWDHSVKKQIKYVSQQSNRFNKSTLNKLKEFDIDSVYVNKLPKETMENVNEAIGYHILRYSIDNMPLGNKNEAFQYLKDVYGITNKESTEFIEMGQIVHDLKKGDTESCLKWCSNEMESLSSNHTALSSLKFDLYTLSAMQIVKHGNPVELYYQITQNAPLDCFRHREKELMQNVVPLLTKSLIGQPIEDIDSKVNKELKECTSLFIKEYCAAKHIFFDSPLFLIVLSGLISFQFFIKYKTIRELAHVDWTTKDELPFDVKLPDFLTHFHPIFICPVLKEETTTENPPYSLACHHIISKKALDRLSKNGTITFKCPYCPVNTSMSSTKKVRFVML
Protein: Fanconi-associated nuclease 1 homolog (AtFAN1) (EC 3.1.4.1) (Q5XVJ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Nuclease required for the repair of DNA interstrand cross-links (ICLs). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (By similarity). May act upstream of the helicase RECQL4A and the ATPase RAD5A, which is involved in error-free post-replicative repair. Functions independently of MUS81 pathway, but in a similar pathway with RECQ4A, RAD5A and MFH1 in ICL repair.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y2M0}. Note=Localizes to stalled replication forks via its UBZ-type zinc finger. {ECO:0000250|UniProtKB:Q9Y2M0}.
Interaction partners:
- Fanconi anemia group I-like protein
- Fanconi anemia group D2 protein
- Crossover junction endonuclease MUS81
- DNA repair endonuclease UVH1
- DNA excision repair protein ERCC-1
- Protein MHF1 homolog
- AT5G65740 protein
- DNA mismatch repair protein MLH1
- DEAD-box ATP-dependent RNA helicase FANCM
- Probable ubiquitin-conjugating enzyme E2 37
Sequence:
MLTGRESLLRLIGKRRRFLPNRHLLLSAHTPNSLNLEFNDYGNLVSLAGDDCRLSEDPTSSDDPSKFSDDLSLSTRKKRRLTQTTLLQSSFLSVPKQLEDGLVICTQQKSILDSETFEFSLVQRSEPSESICCKVEDGSCSPSREESLKTVTLDEDNGEAIETFIVGRKFSDVQDLEIGGDIFLLRHPENVKDRNAIKVISGDSEMLGYLPKDISQCLSPLIDDYDLKFEGTITSVPKKSSEAVLIKVVCHKMRSDGWKECELYGDFKPLWEKVLQVVEHQMQFPPKTTRYQLNFNVLLQEVLRSCSHLFTADEKAFLESFPTLSEDSQRLFIRLYTRKGPWFRLSNISYPEVTDSLQALKDLTVRGFMSSVKDANELDNQKMKEITELLNVTELRDILSMNKVFSRTSRKRDLINSLCSCYNDGTRINLATVILERTGLCAKVSSTAESLIWRVERLFFLNGEQDLSSFVLLDLGIIKYPTYKCIDSEQIFSNRTKLLAYEEAIEVAQLMDESLDNEDPQTVLKCIIIAETRISSSSLDSAHAAAFNRFTAPWVNSKVVLLGVSFFENQKRYNRAVYLLRRLLSCFNCDGRRGYWTVRLSTDLEHMGRPNESLTVAEQGLLDPWVRAGSRVALQRRILRLAKPPRRWKTPTFSNLVDNKIPEVTIQGRSLNCEVGIKNRFYGEDGEQCGVEQLALQYYSGEGGGWQGIHTESSIWLTIFGLLMWDILFSDVPGVFQTRFQTAPLDLETESFYLTRKETIESQLEKVANGMAEEILIISYETQRGTACRGVAWERFSLEELRAAVACVGGMCIASLCRHLAQDYRSWCSGMPDLLVWRFKENGYEGEAKLVEVKSEKDRLSEQQRAWLLLLMDSGFNVEICKVRPASLIKT
Protein: GrpE protein homolog 1, mitochondrial (Mt-GrpE#1) (Q99LP6)
Organism: Mus musculus (Mouse)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Interaction partners:
- Stress-70 protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial disaggregase
- Mitochondrial import inner membrane translocase subunit Tim23
- 10 kDa heat shock protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim17-A
- DnaJ homolog subfamily C member 15
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM16
- Large ribosomal subunit protein bL12m
Sequence:
MAARCVRLARRSLPALALSFRPSPRLLCTATKQKNNGQNLDEDLGHCEPKTDPPSADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKDA
Protein: Contig An16c0060, genomic contig (A2R6Y5)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Interaction partners:
Sequence:
MDISQSRRILRKTFACDECKRRKIRCSGNENCNNCRRDARSCRYSSPSQRLSTLQRRLNESERLRADMERAWAIYLPTVDLQDALHTVRSQNDSITATQQGPHRQKHLSDVTHATEQPPAGFVEPSNAEDYEFDESQDFDNSTDGMGFLTVDPHKAGYTGPQSGIAALKFLQSLPLYLPLTSFSPLSCLDDDIDGGTACTAQQRRADVLRYLDDYFAFYHPAYPILHEGTFRARVSGALAKPRDGSWPILYNIVLAIGAFVGDSQGTKVDIPFFKEARKHLSMDVLEKGSLSYVQAIVLMANYMQKRNKPNAAFIVIGIGWSMALAIGLHREFGMPSTSPFTMEIRRRVWWTLFVFVSGVQLTLGRPAVSLVGVNVHLPANVDDHDLAVDMDELPECGTGPTITSCLIAQVNLAKIANVVQVELLTHHLPTQQKAADLEQRIHTWYQELPPHFGLSIPLEPRFDIPRRVLLWRSFHLRIVINRPFLFQSIAAKSELTTSTGPVAACLTAADECVASICSFLESTSNRRRGLTWYATCWLLTASFVQATCYIYEPAHSLAQTWKCQIQRAVNCLGSLGSSHDMALRARDVLQNILEHGHGIAVPSDMAPYASSQLPGSFRALWFPTNDQQTFKPNTLGLDDNMSGYAPGSFNAEFLDAAGGLMIQNFFDNYSEERAQNAPGSSIPG
Protein: Insulinoma-associated protein 1a (Insulinoma-associated 1-like protein a) (Zinc finger protein IA-1a) (Q6P0F9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q63ZV0}.
Interaction partners:
- Achaete-scute homolog 1a
- Paired box protein Pax-6
Sequence:
MPRGFLVKRNKKATPVSYRVRSEEDEQGAFVAQDVPCARRPVSPVQFGNPETVYRAMYSPTRPVSREHERACLERRFNLGSPISAESFPAAPNCSDQAPVDLKIGTSNSNRTGTTVTTKRPASDTERKGKPASKKAKAMRKLQFEDEMTTSPVLGLKIKEGPVEQKPRSQCASGDKPLGEFVCQLCREAYADPFSLAQHKCSRIVRIEYRCPECDKLFSCPANLASHRRWHKPKQSAESNKTPAPEKEETSSDRDTPSPGLSESGSEDGLYDCQHCGKKFKRQAYLKKHVTAHHDAPEKPQSHAPLNLSASECHLCPVCGENFPSRMSQERHIRLQHSAQVYPCKYCPAMFYSSPGLTRHINKCHPSENRQVILLQMPVRPAC
Protein: AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) (Q9DB50)
Organism: Mus musculus (Mouse)
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).
Subcellular location: Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Interaction partners:
- AP-1 complex subunit gamma-1
- AP-1 complex subunit mu-1
- AP-1 complex subunit beta-1
- AP-1 complex subunit gamma-like 2
- AP-1 complex subunit mu-2
- AP-1 complex subunit sigma-1A
- AP-1 complex subunit sigma-3
- AP-4 complex subunit mu-1
- AP-2 complex subunit beta
- AP-4 complex subunit epsilon-1
Sequence:
MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEDAKEAETPRSVLEEIGLT
Protein: Solute carrier family 41 member 3 (Q96GZ6)
Organism: Homo sapiens (Human)
Function: Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:27302215}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Transient receptor potential cation channel subfamily M member 6
Sequence:
MDGTETRQRRLDSCGKPGELGLPHPLSTGGLPVASEDGALRAPESQSVTPKPLETEPSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQHWPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQIDDPQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCASSVLTAFLAAFALGVLMVCIVIGARKLGVNPDNIATPIAASLGDLITLSILALVSSFFYRHKDSRYLTPLVCLSFAALTPVWVLIAKQSPPIVKILKFGWFPIILAMVISSFGGLILSKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMWSAPGVLPLQMKKFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLGSSSVGHTAAVPRRCTASPGWGLIQPFICTQHLIVSLLSFYFPFCLLAKTSI
Protein: Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16) (Q9H0C8)
Organism: Homo sapiens (Human)
Function: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11331582}.
Interaction partners:
- Scaffold protein ILK
- Glycogen synthase kinase-3 beta
- Serine/threonine-protein kinase Chk2
Sequence:
MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSGSLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRIGH
Protein: Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3 (Mitochondrial genome-required protein 3) (Q04472)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. Together with MGR1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation. Required for growth of cells lacking the mitochondrial genome.
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1
- Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
- Mitochondrial inner membrane m-AAA protease component YTA10
- Mitochondrial import receptor subunit TOM22
- Mitochondrial metalloendopeptidase OMA1
- PUP1 protein homolog
- Tafazzin
- Prohibitin-1
- Mitochondrial inner membrane m-AAA protease component YTA12
- Protein MGR2
Sequence:
MLLQGMRLSQRLHKRHLFASKILTWTTNPAHIRHLHDIRPPASNFNTQESAPIPESPANSPTRPQMAPKPNLKKKNRSLMYSIIGVSIVGLYFWFKSNSRKQKLPLSAQKVWKEAIWQESDKMDFNYKEALRRYIEALDECDRSHVDLLSDDYTRIELKIAEMYEKLNMLEEAQNLYQELLSRFFEALNVPGKVDESERGEVLRKDLRILIKSLEINKDIESGKRKLLQHLLLAQEEILSKSPELKEFFENRKKKLSMVKDINRDPNDDFKTFVSEENIKFDEQGYMILDLEKNSSAWEPFKEEFFTARDLYTAYCLSSKDIAAALSCKITSVEWMVMADMPPGQILLSQANLGSLFYLQAEKLEADLNQLEQKKSKESNQELDMGTYIKAVRFVRKNRDLCLERAQKCYDSVIAFAKRNRKIRFHVKDQLDPSIAQSIALSTYGMGVLSLHEGVLAKAEKLFKDSITMAKETEFNELLAEAEKELEKTTVLKAAKKEGLN
Protein: Klarsicht, isoform B (LD36052p) (Q7YU15)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus membrane {ECO:0000256|ARBA:ARBA00004126}.
Interaction partners:
Sequence:
MEMQQENETGREGVIPNSEKEVALISNQETEKAAMISGGKEGSVRDLESPNETATTQKIEHTTKPLKLDGIFAMPATPPNRAGLTTKSASSSRSSSLKKQRRGSRGSANLNVAGTGDGAPKRSAPGGGQLNYGTNSVGNDLMKQSQSMTSLKASNEEQQESRDVIQAKLHLERPYNSLKKNSHSNKMHRYSWGSGNSQCSSTSLHSSATLGLGSSGKDDLWAAIQTNYNYIMDTNLLDTCKEARCEIEGAATVLEKSSECSFKMLDETQRPEGLCEDPKELRRWLREMENKLESSPTITELTLFGNAELQRHLAVHSVLYHEIASHARVVSSCIRAAEKEQQLQQQQQLSSQQPASLTSNCSSESTSESATKSSSLSSGFASDPVTTPIGTAAAAPPSSSTHPSKKGEGNLERLRDRYHLLYLKAFELQLCLDNLLRKRSSAANGLDDDEDEEEDTEDDSFGYEGEATEDDLNEVNSDLDLENSESKSATPAELILQRCQIAATQIVCGLDETQSQSRSQQVPSQAKSPSADQPRDCLAPQKILKSADASTDDDDEGWLYTATAAATLEVATAATAAPTAAAATSSVDGLQSTAVSSTTATGGPLPPSDDSDKENKVALVSATTITAAATATATSIATLHSSNYDSSSACSSSNSNSNSNSNSNGRLTETSATSRVTQLQMQIHSQSQSQSQMELQINGNAIDGRHIISNNNCYSSMQHQPQNNNEGEAAEDLAKIKMGDDEAAADMANGNATKSQQMSNGVYSRADSCNFTVWAAETVASCHLPPRSPAKSAKSSKSQASNATVSGSTLVSPVKGKVSHDSIKQLVLEAEHLVRDAQETALKTPTKQKHSIIKISSTVKKREVTMPHPIKQRVEEWLEHQPSTPQLLTRSHTHELLPSCKPDDCEASGEASETDSVPQAGAGVNGGAPNGAGSDTSEGFTDSIATCMQTSTNSYGNSTERIGGSAEPIGQPVTPLGFGSSNQSLNVKIVKRSQTRRKSERPWSVSCLSQLTTDAAQLTTARIVENSPSGLASHSISESALDSLSPGPRPRAASSSGTGSNAAKKADSKGSLRRRKARKKRISAASAGRKSDSGSELGGDLTQTLMKSCESMSSQQLQEFTNALLSIQKGAVVAPLSPKGDVSGVPSLADGEGGETQLMLPKFRVGSFTTAGLLATDTRLGALAALSNYMNEDEQQAELSTEDHHSSISETAWDNYQEKYNSENYSEGFDSDAARRLLEFGDDYRNFIDSQSDCCSSLSAANNLDSFSPPRMDSLQKHELKTLHINQDTITSTVDHARRQRALELQYERRRKTLEVRRKSCQDMDESLMASPQSDQQQQQLQVTPSLSASATALMTTPKIQSTSHQISHRAESVGRKLDFGGMSHSAQSLLRRTSESDTSTRRRRTVTADERRRSSRNLEKCIKLIPATTSSSSGSDSEDGEQEMRSLLQQSRDRLDDTRALKIRCHLLRPEDYNEIINTCRDNIRCLEAVLRGPPGTVLSNHCAGQTKDLLGAWEDLLSWSENASAARKLQQEMSVLKSSLQRLGDKPTPELLDTEPAIQIAVEALKLEQTQLTSYRTNMLRLNASVHSWLTKQERRLQSALEEQEQQQESEQLKQQKLVEEEKGADVQKELASTGAVAITVTDSNGNQVEALATGEASTSTPAWDVHTLMSSEQEFHKHLKNEVSDMYSSWDEADARINTQLEMLTNSLIAWRQLESGLSEFQLALGQDRGTLKGLEGALDKGQATPVELAQNVKLVAKLLSEKVHVSQEQLLAVQQHLDPNHIYHITKFTASNGSLSDSGISDGGATSDGGLSERERRLGVLRRLAKQLELALAPGSEAMRSIAARMESAEADLKHLQNTCRDLIVRTAASHQQKQQIQQNQTQQVSPKANGHIKKQAAKGKAEPQSPGRRGKGARKARQAKKAGEDQQVEEPSLSPEQQKMVLKQLKTLTSGDGGDDPSDDPSLLFNLESSEEDGEGADPAQTSKRGWAWRIARAAVPMQVALFTIFCAACLMQPNCCDNLNNLSMSFTPQLRYIRGPPPI
Protein: Inactive peptidyl-prolyl cis-trans isomerase shutdown (H9IWW7)
Organism: Bombyx mori (Silk moth)
Function: Co-chaperone required during oogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with Hsp83/HSP90 and is required for the biogenesis of all three piRNA major populations (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Heat shock protein 83
Sequence:
MEFQIDVDFQNRKTEMFINGDDDLFPEMGDEDDSDGEDTLRNIEETTKKMMLASPDYLSFEELGANMIDCMSTGDVKMLIIEEGKGPLVPVDSEVTIHYAAYWEKAVIPFDSTLTMNMGAPKRLRLGTGKIIPGLEIGLTMVKGPQARLNLLVQPAAAWGPRGVPPRIRPEPALFVIVLYDVKDNYAATRFNDLPMAEQTKYEVTLRTVNALRADAKELYKKKKYVKAIKNYQQAISVLRLSRPGTADEELDIKNNKVNAYLNLAVCYYKTNKPKHVLNMCECLDRLIDTEKHCKALYYYGKAHEMLGKTEMAIKYYKKALKLEPKNKEIGKILADLDTKTKDFAVNEKAMWLKAFNVEVPATNAVYDVDATFQSDVLDMCQSLAGRSEFAKFDLPVGLTKNEVDCIKGIVSDFGCLSVDVSGEGRNKKVCIVKKIV
Protein: Growth-regulating factor 8 (AtGRF8) (Transcription activator GRF8) (Q9SU44)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues. Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU01002}.
Interaction partners:
Sequence:
MRMLLGIPYVDKSVLSNSVLERGKQDKSKLLLVDKCHYELDVEERKEDFVGGFGFGVVENSHKDVMVLPHHHYYPSYSSPSSSSLCYCSAGVSDPMFSVSSNQAYTSSHSGMFTPAGSGSAAVTVADPFFSLSSSGEMRRSMNEDAGAAFSEAQWHELERQRNIYKYMMASVPVPPELLTPFPKNHQSNTNPDVDTYRSGMFSIYADYKNLPLSMWMTVTVAVATGGSLQLGIASSASNNTADLEPWRCKRTDGKKWRCSRNVIPDQKYCERHTHKSRPRSRKHVESSHQSSHHNDIRTAKNDTSQLVRTYPQFYGQPISQIPVLSTLPSASSPYDHHRGLRWFTKEDDAIGTLNPETQEAVQLKVGSSRELKRGFDYDLNFRQKEPIVDQSFGALQGLLSLNQTPQHNQETRQFVVEGKQDEAMGSSLTLSMAGGGMEETEGTNQHQWVSHEGPSWLYSTTPGGPLAEALCLGVSNNPSSSTTTSSCSRSSS
Protein: Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) (P41279)
Organism: Homo sapiens (Human)
Function: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:8226782}.
Interaction partners:
- Nuclear factor NF-kappa-B p105 subunit
- TNFAIP3-interacting protein 2
- Dual specificity mitogen-activated protein kinase kinase 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- RAC-alpha serine/threonine-protein kinase
- Mitogen-activated protein kinase kinase kinase 14
- Dual specificity mitogen-activated protein kinase kinase 4
- NF-kappa-B essential modulator
- Dual specificity mitogen-activated protein kinase kinase 2
Sequence:
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
Protein: Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Liver regeneration-related protein LRRG077) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) (Q7TP47)
Organism: Rattus norvegicus (Rat)
Function: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Is associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Binds to apoB mRNA AU-rich sequences. Part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. May be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:O43390}. Cytoplasm {ECO:0000250|UniProtKB:O43390}. Nucleus {ECO:0000250|UniProtKB:Q7TMK9}. Microsome {ECO:0000250|UniProtKB:Q7TMK9}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Expressed predominantly in the nucleoplasm. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). {ECO:0000250|UniProtKB:O43390, ECO:0000250|UniProtKB:Q7TMK9}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein U
- Y-box-binding protein 1
- Bifunctional glutamate/proline--tRNA ligase
- ATP-dependent RNA helicase A
- Large ribosomal subunit protein uL13
- Heterogeneous nuclear ribonucleoprotein D0
- Y box binding protein 1, pseudogene 20
- Polyadenylate-binding protein-interacting protein 1
- Glyceraldehyde-3-phosphate dehydrogenase
- Polyadenylate-binding protein 1
Sequence:
MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKSFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENEEFYQDTFGQQWK
Protein: Solute carrier organic anion transporter family member 1A6 (Kidney-specific organic anion-transporting polypeptide 5) (OATP-5) (Solute carrier family 21 member 13) (Q99J94)
Organism: Mus musculus (Mouse)
Function: May mediate the Na(+)-independent transport of organic anions.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Hepatic sodium/bile acid cotransporter
- Bile salt export pump
- Organic anion transporter 3
- ATP-binding cassette sub-family C member 2
- Monocarboxylate transporter 8
- ATP-dependent translocase ABCB1
- Solute carrier family 22 member 7
Sequence:
MGEPGKRVGIHRVRCFAKIKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLPHFLMGRYEYETTISPTSNLSSNSFLCVENRSQTLKPTQDPAECVKEIKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNVLTSIPFFFFPKTLPKEGLQDNGDGTENAKEEKHRDKAKEENQGIIKEFFLMMKNLFCNPIYMLCVLTSVLQVNGVANIVIYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTPIAGLTTSYEGIQQSFDMENKFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCIRSSGNSSAVLGLCKKGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLRCMKSEEKSLGIGLQAFFMRLFAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRTYEVSSFRRLYLGLPAALRGSIILPSFFILRLIRKLQIPGDTDSSEIELAETKPTEKESECTDMHKSSKVENDGELKTKL