wanglab/gogpt-training-data huggingface dataset:
Protein: Hydroxyproline O-galactosyltransferase HPGT2 (EC 2.4.1.-) (Beta-1,3-galactosyltransferase 10) (Q94A05)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q94F27}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Hydroxyproline O-galactosyltransferase GALT5
- Hydroxyproline O-galactosyltransferase GALT6
- Hydroxyproline O-galactosyltransferase GALT2
- Hydroxyproline O-galactosyltransferase GALT4
- Beta-glucuronosyltransferase GlcAT14B
- Beta-arabinofuranosyltransferase RAY1
- Beta-glucuronosyltransferase GlcAT14C
- Beta-glucuronosyltransferase GlcAT14A
- Beta-1,3-galactosyltransferase GALT1
- Beta-1,6-galactosyltransferase GALT29A
Sequence:
MESLPTTVSGKSDRRGRFSKSQNTSKPSLILAFFSCLAWLYVAGRLWQDAQYRAALNTVLKMNYDQRPKVLTVEDKLVVLGCKDLERRIVETEMELAQAKSQGYLKKQKSVSSSGKKMLAVIGVYTGFGSHLKRNKFRGSWMPRDDALKKLEERGVVIRFVIGRSANRGDSLDRKIDEENRATKDFLILENHEEAQEELPKKVKFFYSAAVQNWDAEFYVKVDDNVDLDLEGMIALLESRRSQDGAYIGCMKSGDVITEEGSQWYEPEWWKFGDDKSYFRHATGSLVILSKNLAQYVNINSGLLKTYAFDDTTIGSWMIGVQATYIDDNRLCCSSTRQEKVCSMA
Protein: Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Q84WG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act in low affinity electroneutral exchange of protons for cations such as Na(+) or K(+) across membranes. May also exchange Li(+) and Cs(+) with a lower affinity.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:17151019}; Multi-pass membrane protein {ECO:0000255}. Note=Tonoplast.
Interaction partners:
- Sodium transporter HKT1
- Calcineurin B-like protein 4
- CBL-interacting serine/threonine-protein kinase 24
- Probable calcium-binding protein CML18
- Protein PLANT CADMIUM RESISTANCE 12
- Pyrophosphate-energized vacuolar membrane proton pump 1
Sequence:
MVIGLSTMLEKTEALFASDHASVVSMNLFVALLCACIVLGHLLEETRWMNESITALIIGSCTGIVILLISGGKSSRILVFSEDLFFIYLLPPIIFNAGFQVKKKQFFRNFMTIMLFGAIGTLISFVIISFGAKHLFEKMNIGDLTIADYLAIGAIFSATDSVCTLQVLNQDETPLLYSLVFGEGVVNDATSVVLFNAIQRFDLTNINSAIALEFAGNFFYLFILSTALGVAAGLLSAFVIKKLYIGRHSTDREVALMMLLAYLSYMLAELFHLSSILTVFFCGIVMSHYTWHNVTDKSKVTTKHTFAAMSFLAEIFIFLYVGMDALDIEKWDVVRNSPGQSIGVSSILLGLILLGRAAFVFPLSFLSNLTKSSPDEKIDLKKQVTIWWAGLMRGAVSMALAYNQFTTSGHTKVLGNAIMITSTITVVLFSTVVFGLLTKPLVKHLQPSSKQSSTTALQITLRSSFHDPILHEPLLSTQGQSEYDPEQHVSFRMFWKSPSRFTH
Protein: Serine/threonine-protein kinase 4 homolog B (EC 2.7.11.1) (Kinase responsive to stress B) (STE20-like kinase krsB) (Q55FS2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Probable serine/threonine-protein kinase.
Interaction partners:
Sequence:
MEESGQLSDFKLPEGIKDPSLEFDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPINEDFQEILKEINIMKQCKSKYVVQYYGNYFKDETCWIIMEYCAFGSVSDMMNITNRVLNEEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTRKRNTVIGTPFFLAPEVIQEVGYDNKADIWALGISAIEMAEFHPPYHDLHPMRVLFMIPTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFFEKKLKGSYVMKSLSETAQMVIERCGGREEAVKAAAERKSKQSGVSVDFIHCESVDEPDSSDEEDLLERNNKRLSTQIQQKKEQQAQQQQQQAQQQQQQQQQQQQQYQPPSPNNNNRTTTKNNDINELDSLLNNMMMSSSASASTSPSPSSISSNGNKSGTTTNDYHTGNGRTSSSSPQFGLQHQNSSNSFPSSPNTVPSVESKPRQPASELDDLLEEMMNPSFGNRARNSSGGGGGLTPIGSPITKRPTPTMQSSTTTTTSSSSLPLPMSPSVYLSPTRVSGIWSGESAGGCANTTLWRKNPQYLLQITATTTIRITLRQTGDKLVHIGFYFARSNTGANDQFRRRITLTKEYLVPGLDITFLKSTEVSAKITMEPGYYVIIPATFEPNQEGSFELDVTATSDNIGGQYNSNNNIKLSEIKGDRDWRIISDRFEWRGSSAGGSFSGSSATWKDNPKFFFETTQTSNTTIVLGKLSDIPKETYIGFYIFKADKNCPFISLTANNLYSKTSFVNGIEVVHTQQQMPPGCYIIVPCTYDSRQEGSFTLTCYSDCQQGSIYKLDLSEQILTVHGEWRGATSGGCLNHTTWRNNAQYLIHNTSSSPTKVTIMLEQLEKMDNQQLPFVGFYVAKSPTPNLDKKLFSLTPKDIVGNTEFINDYQVHFTSIMEPNTSYIIIPSTFTPGIEYPFNLRVITNQHNVIQISRLPEWSTRKLSGEWRGQSCGGRYSNTSSSWTLNPRFRFNLPRGGRFTIILAQAEKPSYNGIGFYYFKTLQDGTLREFVCKSGFICGKEIVLESSINEGVTGVVIPSTFEPNIQDSFNLTIYSEFDLDFYNN
Protein: B box and SPRY domain-containing protein (Zetin-1) (Q6P6S3)
Organism: Rattus norvegicus (Rat)
Function: May regulate epithelial calcium transport by inhibiting TRPV5 activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12615066}. Membrane {ECO:0000269|PubMed:12615066}; Peripheral membrane protein {ECO:0000269|PubMed:12615066}.
Interaction partners:
Sequence:
MSSDVSGTESGSESGPESVPEPVPEPGPEPESEPGPGPAPGPGPGPAPGPGPGLGREPGQRYQPCQLCPEHGKPLSWFCLSERRPVCATCAGFGGRCHRHRIRRAEEHAEELRNKIVDHCEKLQLQSAGITKYVAEVLQGKNQKAMIMANATREVIIQRLSLVRCLCESEEQRLLEQVHSEEERAHQCILTQRAHWDDKLRKLDSLRTSMVDMLTHLNDLQLIQMEQEILERAEEAEGILEPQESEKLSFNEKCAWSPLLTQLWATSVLGSLSGMEDVLIDERTVGPLLNLSEDRKTLTFNAKKSKVCSDDPERFDHWPNALAVNAFQTGLHAWAVNVKHSCAYKVGVASAQLPRKGSGSDCRLGHNAFSWVFSRYDQEFCFSHNGNHEPLALLRCPTQLGLLLDLQAGELIFYEPASGTVLHIHRESFPHRLFPVFAVADQVISIVC
Protein: Peroxin-13 (Q38E51)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Peroxisomal membrane protein PEX14
- Peroxin 19
- Peroxisome targeting signal 1 receptor
- propanoyl-CoA C-acyltransferase
- Nonspecific lipid-transfer protein, putative
- Peroxisome assembly protein, putative
- Peroxin-7
- RING-type E3 ubiquitin transferase
- Peroxisomal ATPase PEX1
- Peroxisomal ATPase PEX6
Sequence:
MSAAVPVSEGNGGVAAQNPLPSGELPSTTSLAQQPLSPVGTSPPSNALVTAPGTAGTSQNAMPVNTVDQTNRYNNNNEYANSYNTGMGYGGLGMGYGGLGMGYGGLGMGYGGLGMPGMYGGLGMGGLYGGLGMPGMYGMGMSEDFQRSQMTFMLVGRLLEMCGMFAGVIQMTFGSALQFMGNYIGMSQQYNKLKSGMYMDEAGRWVELPKGTDSSRESAVSGTRRRPSRHRKQEKQSHPIFGVLRRLLFLLLAVMLAKRITR
Protein: Mitochondrial dicarboxylate carrier (DIC) (Solute carrier family 25 member 10) (O89035)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane. Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:3355813}; Multi-pass membrane protein.
Interaction partners:
Sequence:
MAEARTSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALQVVRTDGFLALYNGLSASLCRQMTYSLTRFAIYETMRDYMTKDSQGPLPFYSKVLLGGISGLTGGFVGTPADLVNVRMQNDMKLPLSQRRNYSHALDGLYRVAREEGLKKLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFLSSFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETAKLGPQAFFKGLVPAGVRLVPHTVLTFMFLEQLRKHFGIKVAT
Protein: Oil body-associated protein 1B (Q8GWR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Oil body-associated protein 2C
Sequence:
MEKAVHSSTTSGPAVPGETTKTGTSIIDTAASAVQSFAPVNQIHQHLCAFHFYADDMARQVEAHHFCSHVNEEMRQCLIYDGPDANARLIGLEYIVSEKLFMTLPDEEKKLWHSHEWEVKGGFLFMPGVPGAIQRKDLDKVAKTYGKVFHFWQVDLGHELPIGLPNVMMAVTRDGQLFHEMIQEAEKRFGVSVEGERDSRAYMSGPELGIHPLANGGGKGMKLELREVDIKPVESVGSVFV
Protein: Protein unc-13 homolog B (Munc13-2) (munc13) (Q9Z1N9)
Organism: Mus musculus (Mouse)
Function: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release.
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus. Synapse {ECO:0000250}. Note=Localized to synapses (By similarity). Translocates to the Golgi in response to phorbol ester binding. {ECO:0000250}.
Interaction partners:
- Regulating synaptic membrane exocytosis protein 1
- DNA endonuclease RBBP8
- Protein bassoon
- Ras-related protein Rab-3A
- Calmodulin-1
- Synaptosomal-associated protein 25
- Syntaxin-1A
- Vesicle-associated membrane protein 2
- Synaptotagmin-1
- Protein unc-13 homolog C
Sequence:
MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGLSVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTKNPTPHKILLDTRFELPFDIPEEEARYWTYKLEQINALADDNEYSSQEESQRKPLPTAAAQCCHWTYLGWGEHQTFEDPDSAVDDRDSDYRSETSNSAPPPYHTTTQPNASVHQFPVPVRLPQQLFLQGSSHDSCNDSMQSYDLDYPERRALSPTSSSRYGSSCNVSQGSSLLSELDQYHEQDDDGRERDSIHSSHSYGSLSKDGQAGLGEQEKALEVTCESEKEKTGESKEMRDDATIHPPSDLVLHKDHVLGPQESLPEETASSPFTQARAHWFRAVTKVRLQLQEISDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWSATTPTYCYECEGLLWGLARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVSKVAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVWIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSHQYQLQEQPLEEPGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLSQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDRLCKSADYMNLHFKVKWLHNEYVRDLPALQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPNILAHYMRRFAKTIGKVLMQYADILSKNFPAYCTKERLPCILMNNMQQLRVQLEKMFEAMGGKELDSEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPNARASVAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERVIVLPPLTDQTGTQLILTAAKELSQLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTAQGAGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWTPKYNETFHFLLGNEEGPEAYELQICVKDYCFAREDRVIGLAVMPLRDVAAKGSCACWCPLGRKIHMDETGMTILRILSQRSNDEVAREFVKLKSESRSTEEGS
Protein: NSDC (Q56UE1)
Organism: Emericella nidulans (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAALMQSNNEPVAISTPLTASSDPIASSSPGSATFLKQSKPDSNLTSIANAGLNVTRSKDSLPAMSTTAVPNSGSAERQLESHRDADQDSSQVAREALGASEKHQSSSVGDSLAIHSDQMQVDSHPGPGEAGDPVFNTAENGTSLINSSTVASPGPIEDSVSQDGDQPRHRDDGDLHQENNNKAFSYPMPTGAFNDPRRGLSLPSSGLHKAGQRSPSAKKHRCPYCATEFTRHHNLKSHLLTHSQEKPFVCTTCQSRFRRLHDLKRHQKLHTGERPHICPKCGRRFARGDALARHNKGQGGCAGRRASMGSYAPEDEYGDAAAAGADEAMDGLVYAEPERMDEDDERRYNMPSIKKHDVPSDSAVRSNSVSSYQARQPSTYPPIAASRPSPGGLFPPPTSHGGSSASPSPISQSGNMAFPSTNQPSGSSAFAPSNMAESPRPLSPNALSSHQLGHGPENGLQMHHRAHSAGISHPFPQQSYNRTGPSQASLSNHTAPSLGLPPPQPGAPQLPPPPGLGSSEPRFSLHSQSSVQASGSAAKHTPSHSHSSNHGGSLTSKTIPEAASTHNVHTSHDPSVFDQQREREEKLWEYIRSVHEELNGLKSEVATLRAQVASSSVNASTTSGSSVTQSSVETGTTNTVQR
Protein: Uncharacterized protein (Q386P8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLQNCWLLADFDGTIVATPHKARGEYLTLSESPCIIPVKRWLANGGNLCVITTANKRVVQQLYVPLREILRDKYCVNSSDSCGESVESDGESPSNTGNGSVSGQNDGKSIATNRYCGQLLLSLNTGAVLYRCSRQGISFVPGYTEALHRATEDSRRLAKVYGVKLDQGTTTRVDSKGEKHVTNIEYVRGTCFAQGCSALIARLEKTYLELVEDLIRGEKKGVHSAFLGLSSRYQNVWRLVFDYIDRRYRLQQKGRADSGARVQSRAGRNHVGKAATTAEAEWKCSFVRKHKQMFVMFGFIHVEVADAEIAPLAETLSVVGGAKASDIEKVKRRQLREYAKQMFNDDSDAACIVVRKVMDLLGATIPKTFSSGRNAVAAFANRMYNALFCQQSKESITQVLALGVPMKIFPLYFEPMQRYFAAVGVTAIPQPNSVAFGKLGICKSTTVRYLTDESEQQQNMQAGLCGVVDLTQAIALGDNPHTADYELTVHPGLRFISLEKAKQRRDRHTYIDARCTRADSNHEAPECHVVNTNGDENEPQPRGMLMDDRRVKNIYYVGGEEDGTAVFLDRLMDILGVPPGFPNRDDSQQKLKPLERSTFAEAVPLAATQAAAVMNPSMAHL
Protein: Probable mitochondrial phosphate carrier protein (Q9P7V8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transport of phosphate groups from the cytosol to the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- ATP synthase subunit alpha
- Cytochrome b-c1 complex subunit 2, mitochondrial
- ATP synthase subunit beta, mitochondrial
Sequence:
MSTPLIPPAPPKKTLQLYTPQYYGLCTLGGLLACGTTHSAITPLDLIKCRKQVNPNIYPGNIAGFKTILSKEGLRGLYTGGMPTLIGYSLQGCGKYGFYELFKHKYSTLVGAQKAHEYRTSIYLAASASAELLADIMLCPMEAIKVRVQTSNPRFANTTREAWSKIVTNEGFGTLYRGLAPLWFRQIPYTMMKFASFERIVEALYTYIGKPKNMYSKAEKIGISFAGGYMAGVLCAIISHPADVMVSKLNSNKKAGEGAGAAAARIYKEIGFSGLWNGLGVRIVMIGTLTGAQWLIYDSFKIMCGFPATGA
Protein: At2g45350/F14N22.7 (F14N22.7/F14N22.7) (Homeodomain-like superfamily protein) (Q9SJJ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Zinc finger
- At3g13230
- Uncharacterized protein
- Phosphoglycerate mutase family protein
- Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein
- Glycine-rich protein
- EPIDERMAL PATTERNING FACTOR-like protein 8
- At3g15680
- ALC-interacting protein 1
- High mobility group B protein 15
Sequence:
MAGRSSPGKCSTWLDLNREETVEKNNEEESSVEDEDQITNNVRQYIRSNMPRLRWTPDLHLSFVRAVQRLGGPDRATPKLVLEMMNLKGLSIAHVKSHLQMYRSKKLEPSSRPGFGAFMSGQRSYLMDMIDSRCIPHSDLRHAYNSKTVPSRVLNQDAVVTNLGGNFLMRPSSWFSGLCRNDRDSTENKTLPLLEIRKKNNEKRVRDEEVSSVKRLKSMSGGGIQLPEFGNCRQKPTDDINTMLSLSLLSTSSEP
Protein: Synaptogyrin-2 (Cellugyrin) (O43760)
Organism: Homo sapiens (Human)
Function: May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O54980}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O54980}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to cytoplasmic vesicles associated with the recycling endosomes. {ECO:0000250|UniProtKB:O54980}.; SUBCELLULAR LOCATION: Lipid droplet. Note=(Microbial infection) Upon SFTS phlebovirus infection, the protein localizes in lipid droplets and inclusion bodies. {ECO:0000269|PubMed:27226560}.
Interaction partners:
- Transmembrane channel-like protein 8
- Transmembrane channel-like protein 6
- Synaptoporin
- Thymidine kinase, cytosolic
Sequence:
MESGAYGAAKAGGSFDLRRFLTQPQVVARAVCLVFALIVFSCIYGEGYSNAHESKQMYCVFNRNEDACRYGSAIGVLAFLASAFFLVVDAYFPQISNATDRKYLVIGDLLFSALWTFLWFVGFCFLTNQWAVTNPKDVLVGADSVRAAITFSFFSIFSWGVLASLAYQRYKAGVDDFIQNYVDPTPDPNTAYASYPGASVDNYQQPPFTQNAETTEGYQPPPVY
Protein: Protein KIBRA (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) (Q5SXA9)
Organism: Mus musculus (Mouse)
Function: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance (By similarity). Regulates collagen-stimulated activation of the ERK/MAPK cascade.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8IX03}. Nucleus {ECO:0000250|UniProtKB:Q8IX03}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q8IX03}. Cytoplasm, cytosol {ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:21943600}. Note=Colocalizes with PRKCZ in the perinuclear region. {ECO:0000250|UniProtKB:Q8IX03}.
Interaction partners:
- Serine/threonine-protein kinase LATS1
- Merlin
- Angiomotin
- Dendrin
- Tyrosine-protein phosphatase non-receptor type 14
- FERM domain-containing protein 6
- Serine/threonine-protein kinase LATS2
Sequence:
MPRPELPLPEGWEEARDFDGKVYYIDHRNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDERMSDAQGGYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPMPKQFLDVSSQTDISGSFSTSSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLAASSLDSSTSASFTDLYYDPFEQLDSELQSKVELLFLEGATGFRPSGCITTIHEDEVAKTQKAEGGSRLQALRSLSGTPRSMTSLSPRSSLSSPSPPCSPLITDPLLTGDAFLAPLEFEDTELSTTLCELNLGGSGTQERYRLEEPGPEGKPLGQAASVAPGCGLKVACVSAAVSDESVAGDSGVYEASAQRPGTSEAAAFDSDESEAVGATRVQIALKYDEKNKQFAILIIQLSHLSALSLQQDQKVNIRVAILPCSESSTCLFRTRPLDSANTLVFNEAFWVSISYPALHQKTLRVDVCTTDRSHTEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQCREPQPTEAPGPDHVDAVSALLEQTAVELEKRQEGRSSSQTLEGSWTYEEEASENEAVAEEEEEGEEDVFTEKVSPEAEECPALKVDRETNTDSVAPSPTVVRPKDRRVGAPSTGPFLRGNTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRMKRPSSVKSLRTERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEHLEQAKNHGEKELPQWLREDERFRLLLRMLEKKVDRGEHKSELQADKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV
Protein: Caveolin-1 (P35431)
Organism: Gallus gallus (Chicken)
Function: May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane raft {ECO:0000250|UniProtKB:Q03135}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
Interaction partners:
- Proto-oncogene tyrosine-protein kinase Src
- Caveolin
- Leucine zipper protein
- Integrin beta-1
- Integrin beta
- Dynamin 2
- Integrin beta
- Integrin beta
- Integrin beta
- Caveolin
Sequence:
MSGTKYVDSEGFLYAAPVREQGNIYKPNNKMMADELSEKAVHDVDTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSAIFGIPMALIWGIYFAILSFLHIWAVVPCIRSYLIEIQCISRVYSICIHTFCDPLFEAMGKVFSSIRATVRKEI
Protein: Acyl-coenzyme A diphosphatase FITM2 (EC 3.6.1.-) (Fat storage-inducing transmembrane protein) (Fat storage-inducing transmembrane protein 2) (Fat-inducing protein 2) (Q9VRJ2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required for correct morphology of nociceptive multi-dendritic sensory neurons. Required for normal mechanical amplification in hearing.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03230}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03230}.
Interaction partners:
- Atlastin
Sequence:
MATKRRPLRPNLGGTAGSPSSSGSNMNFRPGGPDITRSEARGTRPTAAPTSIREILVMGVIHLCKKTIFFNTDLKVALYLGSLFVISVIGDFVPFPKTYFARSDNLFNQYFVKIGWGWTLLFVVPFLVLSAYTITCGDHKRMLRHHFPRIVIATFFWFFWTKLFNVVENSYGRCTTKGYATKSSCLKAGHLWKGFDISGHAFILIHSSLVLIEEARPIIRWETIKEHIRNERHNRSTAENSGTNPLRTLNEEQMRSLQFLYKRLTPIIRTLFIGMAALQLLWDIMLVGTMLYYHRMIEKVISGIIAILTWYFTYRFWYPTPGLLPEAPGNGSFSYQREIPTFPFKRPSHLSTGAATTSSGSNSSRTNLNGKAATTGVPRDQQIPTFMGMPLFTSPKAASAAANLLMSDQQKRERDREQQTLES
Protein: Septation initiation protein sid4 (O60187)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for activation of the spg1 GTPase signaling cascade which leads to the initiation of septation and the subsequent termination of mitosis. May act as a scaffold at the spindle pole body to which other components of the spg1 signaling cascade attach.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:10805785, ECO:0000269|PubMed:11676915, ECO:0000269|PubMed:14655046, ECO:0000269|PubMed:15062098, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Septation initiation network scaffold protein cdc11
- Spindle pole body protein ppc89
- Probable E3 ubiquitin-protein ligase dma1
- Serine/threonine-protein kinase sid2
- Septum-promoting GTP-binding protein 1
- Serine/threonine-protein kinase plo1
- Protein byr4
- Cell division control protein 7
- Serine/threonine-protein kinase sid1
- Tubulin alpha-2 chain
Sequence:
MDEAFGDSLSTDYRWLGHSHFDSHPSAGDSIYFDSLDEDADPSRTARIDRIAELLDGLNDEQISELVNGVNSTTIKENTKKEISNPNDSTRLPLEQIPGSNNLFLDPRHQLGDNSQNAQRHHEPSFNSEKASYTSTPYKNVAPKVIDSPSARHMHSNSPSFPPSQSHTSSYDQSPKGQLRDNISVPNQQDGLDPEVFNQQSKETKKSLQVPPSRNVPPPVTRPNQYNPEPNFSLSSGYPQQHFSQPELQNRNVHLETVPESYPVPPSGYPLTSSTCVSSISQPIQSTDCQKAQENLSNNKQMSSNDQDIDPFKQAITDLPPSFVNIVLEMNATIQSLSNQCQQRDKQIENITKQLLMNQQDYCPTTMSTTVSTPLCPPKRFPKSTKDFKEQKPDTKQVRSATISNDFNLKGNGRYNEKSQIAVPSEIRVQLSTLDAILLQFEHLRKELTQARKEIQILRHTSQNGDQESNESSKNAITTKTTDKGNNKENTMLNDGSTAPAKNDIRNVINTNNLDAKLSDESELMIEKNKSYSTPASSTIPTFHTSQPLTSLNMPDSRFNLAKEKQLYYRLGLQHIDQQCSVETANMLKTVLVQLNIPFAIFPSTIGQVRRQLQQGRRLYQWARNIHYLIYEENMRDGLVSKQCLADMLKKIRELKKRSL
Protein: Gustatory receptor 5a for trehalose (Trehalose receptor) (Q9W497)
Organism: Drosophila melanogaster (Fruit fly)
Function: Gustatory receptor required for response to the sugar trehalose in taste neurons. Gr5a neurons selectively respond to sugars, in contrast to Gr66a cells which respond to bitter compounds. Flies are attracted to sugars and avoid bitter substances, suggesting that Gr5a neuron activity is sufficient to mediate acceptance behavior. Sugar signal transduction occurs through coupling with G-proteins such as Galpha49B and G-salpha60A.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Gustatory receptor for bitter taste 66a
- Gustatory receptor for sugar taste 43a
- Gustatory and pheromone receptor 33a
- Pickpocket protein 28
- Glycine--tRNA ligase
- IP13856p
- Gustatory and pheromone receptor 32a
- Transient receptor potential cation channel subfamily A member 1
- Gustatory and odorant receptor 63a
- Gustatory receptor for bitter taste 93a
Sequence:
MRQLKGRNRCNRAVRHLKIQGKMWLKNLKSGLEQIRESQVRGTRKNFLHDGSFHEAVAPVLAVAQCFCLMPVCGISAPTYRGLSFNRRSWRFWYSSLYLCSTSVDLAFSIRRVAHSVLDVRSVEPIVFHVSILIASWQFLNLAQLWPGLMRHWAAVERRLPGYTCCLQRARPARRLKLVAFVLLVVSLMEHLLSIISVVYYDFCPRRSDPVESYLLGASAQLFEVFPYSNWLAWLGKIQNVLLTFGWSYMDIFLMMLGMGLSEMLARLNRSLEQQVRQPMPEAYWTWSRTLYRSIVELIREVDDAVSGIMLISFGSNLYFICLQLLKSINTMPSSAHAVYFYFSLLFLLSRSTAVLLFVSAINDQAREPLRLLRLVPLKGYHPEVFRFAAELASDQVALTGLKFFNVTRKLFLAMAGTVATYELVLIQFHEDKKTWDCSPFNLD