wanglab/gogpt-training-data huggingface dataset:
Protein: Cysteine-rich hydrophobic domain-containing protein 2 (Q9D9G3)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Associated and found in vesicular structures of Golgi complex. {ECO:0000250}.
Interaction partners:
Sequence:
MADFDEIYEEEEDEERALEEQLLKYSPDPVVVRGSGHVTVFGLSNKFESEFPSSLTGKVAPEEFKASINRVNSCLRKNLPVNVRWLLCGCLCCCCTLGCSMWPVICLSKRTRRSIEKLLEWENNRLYHKLCLHWRLSKRKCETNNMMEYVILIEFLPKTPIFRPD
Protein: Lycopene beta cyclase, chloroplastic/chromoplastic (EC 5.5.1.19) (Q43415)
Organism: Capsicum annuum (Capsicum pepper)
Function: Catalyzes the double cyclization reaction which converts lycopene to beta-carotene. Catalyzes the double cyclization reaction which converts neurosporene to 7,8-dihydro-beta-carotene.
Subcellular location: Plastid, chloroplast {ECO:0000255}. Plastid, chromoplast {ECO:0000305|PubMed:7550379}.
Interaction partners:
Sequence:
MDTLLRTPNNLEFLHGFGVKVSAFSSVKSQKFGAKKFCEGLGSRSVCVKASSSALLELVPETKKENLDFELPMYDPSKGVVVDLAVVGGGPAGLAVAQQVSEAGLSVCSIDPNPKLIWPNNYGVWVDEFEAMDLLDCLDATWSGATVYIDDNTTKDLNRPYGRVNRKQLKSKMMQKCILNGVKFHQAKVIKVIHEESKSMLICNDGITIQATVVLDATGFSRSLVQYDKPYNPGYQVAYGILAEVEEHPFDVNKMVFMDWRDSHLKNNVELKERNSRIPTFLYAMPFSSNRIFLEETSLVARPGLGMDDIQERMVARLSHLGIKVKSIEEDEHCVIPMGGPLPVLPQRVVGIGGTAGMVHPSTGYMVARTLAAAPVVANAIIQYLSSERSHSGDELSAAVWKDLWPIERRRQREFFCFGMDILLKLDLPATRRFFDAFFDLEPRYWHGFLSSRLFLPELIVFGLSLFSHASNTSRLEIMTKGTLPLVHMINNLLQDKE
Protein: Palmitoyltransferase (EC 2.3.1.225) (A0A0B4LEL6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGNDDHRRRKTPCGFCMAVFKWIPVLFITAVIAWSYYAYVVELCIRNSENRIGMIFMLLFYHLFLTLFMWSYWRTIMTSVGRIPDQWRIPDEEVSRLFRADSPDTQKRILNNFARDLPVTNRTMNGSVRFCEKCKIIKPDRAHHCSVCSCCVLKMDHHCPWVNNCVNFYNYKYFVLFLGYALVYCLYVAFTSLHDFVEFWKYDNNGYSAQGQLNASGMGRFHILFLFFIAIMFAISLVSLFGYHIYLVLVNRTTLESFRAPIFRVGGPDKNGYNLGRYANFCEVFGDDWQYWFLPVFSSRGDGYSYPTSSDQSRVSTSSPTQRYDAMGDTTTSRLDGNPTDKLIGASPLDTTNHHHNQSPHQVRSTSVLPTQLLQIQPPSTCRDELNERQQKLANGQSLDCSTPAAMSSPDERGVNGAAVYIEMIGDHPLTSADPAKGFPRPPNGDLPV
Protein: Decapping nuclease (EC 3.6.1.-) (A5JYX9)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU367113}.
Interaction partners:
- Protein containing ALS2cr12
- 5'-3' exoribonuclease 2 homolog
- Protein containing ALS2cr12
- Coiled-coil domain-containing protein 73
- Protein containing ALS2cr12
- Ribosomal RNA-processing protein 42
- Transthyretin-like family protein
- Protein containing ALS2cr12
- Serpentine receptor class gamma-31
- DUF305 domain-containing protein
Sequence:
MAVQVKFEQVGTYFKQHDKKAIPGKLPNRLNDDPDLYGKLKYPLALSLGCKDFKDEGGGDVYESIFDFTRKTANRGTSLKETIDADIFSNRSNLTTIATASKFNREPSEIIALRKNGVIFLYKNEKSYEGKYGGGYNFEKYMTLNEVGHPHNPNEKVSNATCSKVVLRTSFVSRKETIKVYYASEVDAVDKNGNFVEMKSTKSDHGKWLHWNSQKHYFQSFLGNVPTILIGRKDQNDCVYQVDKIKTSEIPKMDVKWKVQNCLAQLFTVLNKIMSKLPDDDQAISVKIADGEISYENAKAEDWNFIHPSFLEYFER
Protein: Protein SOM1, mitochondrial (Mitochondrial inner membrane protease subunit SOM1) (Q05676)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Non-catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. SOM1 facilitates cleavage of a subset of IMP substrates.
Subcellular location: Mitochondrion inner membrane {ECO:0000305}.
Interaction partners:
- Cytochrome c oxidase assembly protein COX20
- Mitochondrial inner membrane protease subunit 1
- Cytochrome c oxidase assembly protein COX18, mitochondrial
- Mitochondrial inner membrane protease subunit 2
Sequence:
MAPPTTIRTRDQALAPLATLDSQTNCRLKELVQWECQFKGAEYVCSPFKRLFEHCIAPDKSATNYEVTDTYTNS
Protein: Collagen alpha-1(XXVI) chain (Alpha-1 type XXVI collagen) (EMI domain-containing protein 2) (Emilin and multimerin domain-containing protein 2) (Emu2) (Q96A83)
Organism: Homo sapiens (Human)
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Serpin H1
- Collagen alpha-1
- Collagen alpha-1
- Furin
- Collagen alpha-1
Sequence:
MKLALLLPWACCCLCGSALATGFLYPFSAAALQQHGYPEPGAGSPGSGYASRRHWCHHTVTRTVSCQVQNGSETVVQRVYQSCRWPGPCANLVSYRTLIRPTYRVSYRTVTVLEWRCCPGFTGSNCDEECMNCTRLSDMSERLTTLEAKVLLLEAAERPSSPDNDLPAPESTPPTWNEDFLPDAIPLAHPVPRQRRPTGPAGPPGQTGPPGPAGPPGSKGDRGQTGEKGPAGPPGLLGPPGPRGLPGEMGRPGPPGPPGPAGNPGPSPNSPQGALYSLQPPTDKDNGDSRLASAIVDTVLAGVPGPRGPPGPPGPPGPRGPPGPPGTPGSQGLAGERGTVGPSGEPGVKGEEGEKAATAEGEGVQQLREALKILAERVLILEHMIGIHDPLASPEGGSGQDAALRANLKMKRGGAQPDGVLAALLGPDPGQKSVDQASSRK
Protein: Transporter (A1ZBC8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MTQLEISKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGTDCHDGNAQNSSGKMSPAQLYFEREILHEVPNIDNGLSLPNWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQALAAPWAWDHASCASFGINSDYAPRPFGNWPAA
Protein: Tumor protein p53 binding protein, 2 (A0A8I6AMB5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRFPSMFWLLFLMFLTVYLSNSEQHFTEVPVTPETVCRDVVDLCKEPGESDCHLAEVWCGSERPVADNERMFDVLQRFGSQRNEVRFFLRHERPPNRDIVSGPRSQDAGVKRNGVKVPGEHRRKENGVNSPRLDLTLAELQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLREIAESQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQQKENLPVSPDGNPPQQAVSAPSRVAAVGPYMQSSTMPRMPSRPELLGKPALPDSSLVMQSAEGPMKIQTLPNMRSGAASQSKGPKAHSASSDWNPSSTDLLPSQGSGSALDQVDEGEIALREKEKKVRPFSMFDTVDQCAPPPSFGTLRKNQSSEDILRDAQTVNKNVAKVPPPVPTKPKQINLPYFGQTAQSSSDVKPDGNPQQLPIAATSMGAKLKPAGPQARVLLSPSAPSGGQDQVLSPASKQESPPAAAVRPFTPQPSKDTFPPAFRKPQTVAASSIYSMYTQHQVPGKNFQQAVQSASTKTHPRGPHFSSVYGKPVIAAAQNPQQHPENIYSCSQGKPGSPEPETEPVSSVHESHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSYPSKSPSSVTVNPESPIEIPNPYLHVEPEKEAGSLVPEPLSPEDMGSASTENSDMPAPPPGLECVSEGVPDNSTTLQDNTEGTNPEAPHLLEVYLEEYPPYPPPPYPSGEPEVSEEDSARMRPPEVTGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYQPQHDDELLLKEGDCMAVVRREDEDETEWWWARLNDKEGYVPRNLLGVSRPNADHVSCVINEAWYELLCRGRAVY
Protein: Probable glutathione peroxidase 8 (GPx-8) (GSHPx-8) (EC 1.11.1.9) (Q8TED1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Glutathione reductase, mitochondrial
- Peroxiredoxin-6
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Glutathione synthetase
- Polyunsaturated fatty acid 5-lipoxygenase
- Glutathione peroxidase 2
- Glutathione peroxidase 3
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Phospholipid hydroperoxide glutathione peroxidase GPX4
- Glutathione peroxidase 6
Sequence:
MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLAFPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKFWKPEEPIEVIRPDIAALVRQVIIKKKEDL
Protein: ornithine decarboxylase (EC 4.1.1.17) (Q9DGJ4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Spermidine synthase
- Ornithine decarboxylase antizyme 1
- Agmatine ureohydrolase
- Ornithine aminotransferase
- Arginase
- Arginase
- Diamine acetyltransferase 1
- Diamine acetyltransferase 1
- Ornithine decarboxylase antizyme 2
- Ornithine decarboxylase antizyme
Sequence:
MTACTGSDFDFAFLEEGFCARDIVEQKINESSLSDDKDAFYVADLGDVLKKHLRWLRVLPRITPFYAVKCNDSRAVVTTLASLGAGFDCASKTEIQIVQSVGVDPSRIIYANPCKQVSQIKYASAHGVQMMTFDSEVELMKVARSHENAKLVLRIATDDSKAVCRLSVKFGATLKSSRLLLERAKELGLDVIGVSFHVGSGCTDPETYSQAISDARYVFDIGAELGYNMSLLDIGGGFPGSEDTKLKFEEIAAVINPALDKYFPVDSGVRIIAEPGRYYVASAYTLAVNIIAKKVIMKEQSASDEEEDVSNDRTLMYYVNDGVYGSFNCILYDHAHVLPTLHKKPKPDERMYPCSIWGPTCDGLDRIVEQCSLPDMQVGDWLLFENMGAYTVAASSTFNGFQKPDIYYIMSRTAWQCMQQIRAQGIPALPLEEPSAGNVPSHCGRESSLDVPAKPCPTQVL
Protein: Copper transporter 2 (OsCOPT2) (Q60EN8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in the transport of copper, in cooperation with SWEET11 and COPT1. Contributes to the removal of copper (Cu) from xylem, and thus to the sensitivity toward bacterial pathogens such as X.oryzae pv. oryzae (Xoo).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20852017}; Multi-pass membrane protein {ECO:0000269|PubMed:20852017}.
Interaction partners:
Sequence:
MDMGGNGMAMPPPPAPVKKARYMHMTFFWGKNTEVLFTLWPGARGGMYALAILFMFALAVLLEFRGYRVLEARLARRRAPRAAAALRTAVHAVRVGVAYLIMLALMSFNGGVFLAIVAGHAAGFLAFRAGLCGGGPAPPLEEDRKNDPVCC
Protein: SD17909p (Q86P47)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
Sequence:
TSCPLRRHTKAGEEEAQNTFVVPDLDSCYSATDRSGGKLLKSTARTSESTTWFSADTKSQPGSQRASKKWVKMAWKMGGNRAATLALLFASSLLLLSAANGADLDTESDDFEDGYVEDVQEEPAVIDGDEKLAYESPVIDAKKFHFADHFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSKAKHAAIAAPLRKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQLKAFNDKTPYTIMFGPDKCGNDVKMHFIFRHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVDHKIINEGSLLTDFKPPVNPPAEIDDPNDLKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWLEDEPDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIENPNYQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDIKRRYIDRESDSFVNKVVELAKANPSIWGIGLVAIVALVALTIYCRFGTAKSQDSAAKKAAAEAKKSDDPQPDDEPEAEEESDERAAGDTSKESTPLSASPKKNQKSDLDDNEEESKAAESREPAQTEESNTKTRKRQARKE
Protein: Potassium voltage-gated channel subfamily Q member 5 (F1LY25)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Potassium voltage-gated channel subfamily KQT member 3
- Potassium voltage-gated channel subfamily KQT member 2
- Potassium voltage-gated channel subfamily KQT member 1
- ATP-sensitive inward rectifier potassium channel 14
- Potassium voltage-gated channel subfamily KQT member 4
- ATP-sensitive inward rectifier potassium channel 12
- Inward rectifier potassium channel 4
- Inward rectifier potassium channel 2
- Sodium channel protein type 10 subunit alpha
- Ubiquitin-like protein FUBI
Sequence:
MPRHHAGGEEGGAAGLWVRSGAAAAAGGGRPGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAAALGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFVYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEAASSKFCSNKQKFFRMYTSRKQSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKTVIDADTALGIDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALTLTSFQIPPFECEQTSDYQSPVESKDLSSSAQNSGCLSRSASANISRGLQFILTPNEFSAQTFYALSPTMHSQTTQVPMSQNDGSSVVATNNLANQISAAPKPAAPTTLQIPPPLSAIKHLSRPEPLLSNPPGVHESISDVTTCLVASKENVQFAQSNLTKDRSLRKSFDMGGETLLSVRPMVPKDLGKSLSVQNLIRSTEELNLQFSGSESSGSRGSQDFYPKWRESKLFITDEEVGAEETETDTFDGTPPPAGEAAFSSDSLRTGRSRSSQNICKTGDSTDALSLPHVKLN
Protein: Cell wall synthesis protein CwsA (Cell wall synthesis and cell shape protein A) (A0QNF5)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Required for regulated cell division, cell wall synthesis and the maintenance of cell shape.
Subcellular location: Cell membrane {ECO:0000305|PubMed:23002219}; Single-pass membrane protein {ECO:0000305|PubMed:23002219}. Note=Localizes to poles and midcell sites.
Interaction partners:
- Cell wall synthesis protein Wag31
- Cell division protein CrgA
- Cell division protein FtsZ
- Isovaleryl-CoA dehydrogenase
Sequence:
MPARADVRLAPRQRLTRGLKYTAVGPVDITRGVLGIGADTAQATAAELRRRYASGKLQRQLAAAAEAVAALPETIQEAVQEVVSPPKKRRRRPLLIAAVAVTVLGGGAAAFSIVRRRSRPQEPPTLAPSVEVAPKP
Protein: GlyPicaN (G5EGU4)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
- Probable syndecan
- LONg
- Heparan-sulfate 6-O-sulfotransferase
- D-glucuronyl C5-epimerase
- Netrin receptor unc-5
- Sulfotransferase domain-containing protein
- Heparan sulfate 2-O-sulfotransferase hst-2
- Fibronectin type-III domain-containing protein
- Sulfotransferase domain-containing protein
- Agrin
Sequence:
MFSDTLAWLLILLLAMPQETHGFYFTRRDIHGVMCSSSFEDQCTMEERSRLQTNTVDMLTRKHQDRVIVIRSFLTSQIRIFNEFFSKTLRTVHMDLDLMFSKTYGSFYQENIQLLNDFFKKIKGFSVSFAETSMKTIVELFFDELFQVMFSIANPFYSITNDQRVCMESFYREIEAFDDIPQKIVNQLSLPLSNWKHFLGSLESLNGILEGYLNITFKEECERGLTRMETCAQCQRISEKPCQAYCVNILSGCTHQMLDSEGAWRAATESMIKLGNQLNHRQNLVSALQPIPVLISEAIMHFQEKRDYITNKMIGKCLLNNEDFGLRKKRSAKFKAFPVITTKRSRDHLILNQMFQSFANKMDEWKVFFGNLPEYLCRGEDWASKEDERCWNGTGVGEYKLPLVNYTNPFSNPEYQGTDFLTFRGNYIEERLRLHWLHSRISHILSGKDSQKSEAYYSHKAEARIQSDDEDYSDYEYESSGNFPGSGSYMSSKREYSPYFRKHDDKIEIVIEPYPVISTSRKHFHSFVIVIFMLFSALFQCSR
Protein: Inner centromere protein, isoform A (Inner centromere protein, isoform B) (LD40404p) (Q7JRJ9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Deterin
- Aurora kinase B
- Borealin
- Australin, isoform A
- Kinesin-like protein
- Aurora kinase
- Serine/threonine-protein kinase polo
- Rac GTPase-activating protein 1
- Fascetto
- Bub1-related kinase
Sequence:
MEDILGVLGSLSDLRRELEVLRKAHFEELDHLFYGTGQPEAEAKPRDSAPAAKSQENSSVTPQQTKKRPKRLTSLAEDQNEPEAPDATANNTSARQSTRVSNSQLLAIAEDEHNSTASLMPPPPVPVSADTTLGSGRPQRAAKLKTEKLLKEPSLNRKMRRPSSEELVKVKVESEQRVSQFNSFTSAQALEENKLAEPELEEPAAETAEQQKPPEEASVTEDVNTTKTLRVKVKREKLSTEAVPPLTNAVSTANVTTVSSVTTEAARPDDTVASNTTTSTEVSKKVRKKKKDVESHRPIKVERFSDLDKSSPVSSRTRKCSSDSRTVQERSIYKDALEDPPVAEQSVAAVAPAAVNETVAISNATLVLGPAPTSDSPIGPAGDATFEVHSNDKKQPLSKQDSLLTEDESVEEKLPTTKLLSSIKAIKLPTRTHELFNPLLQSPVKMRVEAFENAANAQNSMRPKRGKDLQGTPGSNNTPKIGKLPAPTVGRFFTPTQTTSTLPLSSAQPKKGPASASKATSLLKTATGTNLRSVNSTSTKTLSRENSGDDFRKGLHNLAEERKKLREQKHQQAAQQREAKERERAERMAKLAAERAKKQEERKRIEERKRQELEELQRKMRQQEEAEALKKAKFKELEQQKLQQLTGAKPKKMLPPPPKTKYTWEMLHEDDSTDDEGKVTHKRPPAPTWSRSHVRGEAIAMQSHCPTDIIDSFFSVAPTTPDLKQIFPNIDPSQLKRNSSVLWSTPPRYSELPKY
Protein: Apical rhoptry neck protein (Q8I3Z0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKKIYFILLILFHLNFMECFRKYDKNKNKILISHSINNNNNSIKNNNNNNNSIKNNNNNNNSIKNNNNNNNSFSATSFSSEKNKNKSYTNVLKKKNIYIREESNKTTNIKEDEEKNKKINNNDKETNYSFLSLKFFPFILTSLLHTGINQIPRNTEIELYEFEKSPMIRHMLVAEERKNAYTYMFFIVISFVVVVLIALFIFKFFFNL
Protein: Eukaryotic aspartyl protease family protein (Q9C8C9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein DUF642 L-GALACTONO-1,4-LACTONE-RESPONSIVE GENE 1
- E3 ubiquitin-protein ligase ATL15
- Leucine-rich repeat
- Protein DETOXIFICATION 25
- At1g73120
- C3HC4-type RING finger protein
- C3HC4-type RING finger protein
- Protein DUF642 L-GALACTONO-1,4-LACTONE-RESPONSIVE GENE 2
- Alpha carbonic anhydrase 1, chloroplastic
Sequence:
MSPIPKPLFFFFFLNYVSLSTSLSLHLPLTSLPISTTTNSHRFTTSLLSRKNPSPSSPPYNFRSRFKYSMALIISLPIGTPPQAQQMVLDTGSQLSWIQCHRKKLPPKPKTSFDPSLSSSFSTLPCSHPLCKPRIPDFTLPTSCDSNRLCHYSYFYADGTFAEGNLVKEKITFSNTEITPPLILGCATESSDDRGILGMNRGRLSFVSQAKISKFSYCIPPKSNRPGFTPTGSFYLGDNPNSHGFKYVSLLTFPESQRMPNLDPLAYTVPMIGIRFGLKKLNISGSVFRPDAGGSGQTMVDSGSEFTHLVDAAYDKVRAEIMTRVGRRLKKGYVYGGTADMCFDGNVAMIPRLIGDLVFVFTRGVEILVPKERVLVNVGGGIHCVGIGRSSMLGAASNIIGNVHQQNLWVEFDVTNRRVGFAKADCSRVV
Protein: ADAM10 endopeptidase (EC 3.4.24.81) (A8DZ02)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSSKCAFNIVFVSIIFIIIVNGYAKDISGVKRGHERLNEYISHYETLNYDHEHIRASHNRARRSVTKDQYVHLKFASHGRDFHLRLKRDLNTFSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDGRGPRSTSSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQLQQPAISPQQQPQQAFYTPKGVAPPPLQVSFSRPTSLHEQQQQQHHLQQQQQHQQQLEPQQQHAYADAYAALGRGQYESTTRAPNNSKV
Protein: 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase (EC 2.3.1.245) (P76143)
Organism: Escherichia coli (strain K12)
Function: Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02052}.
Interaction partners:
- (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase (Autoinducer 2-degrading protein LsrG) (AI-2-degrading protein LsrG) (Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase) (Phospho-AI-2 isomerase)
- Autoinducer 2-binding protein LsrB
- Autoinducer 2 import system permease protein LsrD
- Autoinducer-2 kinase
- Transcriptional regulator LsrR
- Autoinducer 2 import system permease protein LsrC
- Autoinducer 2 import ATP-binding protein LsrA
- Trans-aconitate 2-methyltransferase
- S-ribosylhomocysteine lyase
Sequence:
MADLDDIKDGKDFRTDQPQKNIPFTLKGCGALDWGMQSRLSRIFNPKTGKTVMLAFDHGYFQGPTTGLERIDINIAPLFEHADVLMCTRGILRSVVPPATNRPVVLRASGANSILAELSNEAVALSMDDAVRLNSCAVAAQVYIGSEYEHQSIKNIIQLVDAGMKVGMPTMAVTGVGKDMVRDQRYFSLATRIAAEMGAQIIKTYYVEKGFERIVAGCPVPIVIAGGKKLPEREALEMCWQAIDQGASGVDMGRNIFQSDHPVAMMKAVQAVVHHNETADRAYELYLSEKQ
Protein: Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L) (P48771)
Organism: Mus musculus (Mouse)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000250|UniProtKB:P14406}.
Interaction partners:
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 6C
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 6B1
- Cytochrome c oxidase subunit 6A1, mitochondrial
- Cytochrome c oxidase subunit 8A, mitochondrial
- Cytochrome c oxidase subunit NDUFA4
- Cytochrome c oxidase subunit 7B, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Sequence:
MLRNLLALRQIAQRTISTTSRRHFENKVPEKQKLFQEDNGMPVHLKGGASDALLYRATMALTLGGTAYAIYLLAMAAFPKKQN
Protein: General transcription and DNA repair factor IIH subunit TFB1 (TFIIH subunit TFB1) (RNA polymerase II transcription factor B 73 kDa subunit) (RNA polymerase II transcription factor B p73 subunit) (RNA polymerase II transcription factor B subunit 1) (P32776)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular location: Nucleus.
Interaction partners:
- General transcription and DNA repair factor IIH subunit TFB4
- Cyclin CCL1
- RNA polymerase II transcription factor B subunit 3
- DNA repair protein RAD2
- General transcription and DNA repair factor IIH helicase subunit XPD/RAD3
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor IIE subunit alpha
- Serine/threonine-protein kinase KIN28
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- General transcription and DNA repair factor IIH subunit TFB2
Sequence:
MSHSGAAIFEKVSGIIAINEDVSPAELTWRSTDGDKVHTVVLSTIDKLQATPASSEKMMLRLIGKVDESKKRKDNEGNEVVPKPQRHMFSFNNRTVMDNIKMTLQQIISRYKDADIYEEKRRREESAQHTETPMSSSSVTAGTPTPHLDTPQLNNGAPLINTAKLDDSLSKEKLLTNLKLQQSLLKGNKVLMKVFQETVINAGLPPSEFWSTRIPLLRAFALSTSQKVGPYNVLSTIKPVASSENKVNVNLSREKILNIFENYPIVKKAYTDNVPKNFKEPEFWARFFSSKLFRKLRGEKIMQNDRGDVIIDRYLTLDQEFDRKDDDMLLHPVKKIIDLDGNIQDDPVVRGNRPDFTMQPGVDINGNSDGTVDILKGMNRLSEKMIMALKNEYSRTNLQNKSNITNDEEDEDNDERNELKIDDLNESYKTNYAIIHLKRNAHEKTTDNDAKSSADSIKNADLKVSNQQMLQQLSLVMDNLINKLDLNQVVPNNEVSNKINKRVITAIKINAKQAKHNNVNSALGSFVDNTSQANELEVKSTLPIDLLESCRMLHTTCCEFLKHFYIHFQSGEQKQASTVKKLYNHLKDCIEKLNELFQDVLNGDGESMSNTCTAYLKPVLNSITLATHKYDEYFNEYNNNSN