wanglab/gogpt-training-data huggingface dataset:
Protein: Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Q7ZT11)
Organism: Gallus gallus (Chicken)
Function: May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Myopalladin.
- CCN family member 1
- CTCK domain-containing protein.
- Uncharacterized protein.
Sequence:
MMTMKVEELVTGKKTDDKESGSFLPEDFKTGEYEAAVKLEKQDDLRTASDHLSTQVDMAHGKEKKREAELKKKKLQERSKLESLEDLEKIIQLKKKKKCRKVKAPLLKEPEPEVITGPVDIAMFFRAALENKLPVIEKYLSDKGDPNVCNEYKRTALHRACSEGHLEVVKKLVEAGALLELKDMLESTALHWACRGGNLEIVKFLLDKGINRNARDKLRSTPLHVAVRTGQHDCAEHLIACEADLNAKDREGDTPMHDAVRLNRYKMVRLLILYGADLTIKNVDGKTPMDLVLQWQNGTKELFNNLKNNSYKSAHLNKF
Protein: Histone acetyltransferase (EC 2.3.1.48) (Q8III2)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361211}.
Interaction partners:
- DNA methyltransferase 1-associated protein 1, putative
- Enhancer of polycomb-like protein
- PI3K/PI4K catalytic domain-containing protein
- Zinc finger protein, putative
- Histone H4
- Bromodomain protein, putative
- Histone H2A
- Histone H3-like centromeric protein CSE4
Sequence:
MVLGGKNENKVNVIKGAGSIGKYIMKENGSKIKEVGEWNNSSENENSDNNNNDREDNIKEKVDNNNKNDDNNNNDREDNIKEKVDNNNNNDDNNNDNNNNNKSDNNNNKSDNNNNKSDNYNNKIGDVSNIPSTNTSTVSNKIQGKGSVSYKSKEKTGDHSSNNKNTKGNNNKVRTSGKVINSLSKYSDSYALIFPNALPVKQVLWGLDPLNKVWRYCSIVYARPKNKVLNDTNFMFPLNMNKNEIINKVNNELNNNNSVSMSEGDYDYYVHWEKFDRRLDCWLAYENLRLLDKEPDDGLPLIKDNDNVSDHEHAGIDKEYLREHEENTKLKTINQIRFGKYLIDTWYFSPYPKEYQNIDILYICEFCLSFFKEYSELKRHIEKCEIRHPPGNEIYREEKISIFEIDGSYFRIYCENLCFLSKLFLDHKTLKHRVNLFLFYVITEYDEYGYHITGYFSKEKYSKNNVSCILTLPQHQKKGYGKFLINFSYFLSQTEKRTGTPERPLSDLGVASYMAYWYETILKVLINYEQLSIQELSEITSIETNDIISCLEEKDIFKNSLNGLDSFYYINPKQLEFILNKLKQTNNTQLSKNKLHWVSYDYYLALYE
Protein: UPF0603 protein At1g54780, chloroplastic (Thylakoid lumen 18.3 kDa protein) (Q9ZVL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:11719511, ECO:0000269|PubMed:18431481}; Single-pass membrane protein {ECO:0000269|PubMed:11719511}; Lumenal side {ECO:0000269|PubMed:11719511}.
Interaction partners:
- Cytochrome c oxidase subunit 1
- Cytochrome b6-f complex iron-sulfur subunit, chloroplastic
- Protease Do-like 1, chloroplastic
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 3
- Cytochrome b-c1 complex subunit Rieske-2, mitochondrial
- Cytochrome b-c1 complex subunit Rieske-1, mitochondrial
- Protein disulfide-isomerase LQY1, chloroplastic
Sequence:
METLLSPRALSPPLNPKPLSLHQTKPTSHSLSLSKPTTFSGPKHLSTRFTKPESRNWLIDAKQGLAALALSLTLTFSPVGTALASEFNILNDGPPKETYVVDDAGVLSRVTKSDLKKLLSDLEYRKKLRLNFITVRKLTSKADAFEYADQVLEKWYPSIEEGNNKGIVVLITSQKEGAITGGPAFIEAVGENILDATVSENLPVLATDEKYNEAVYSSAKRLVAAIDGQPDPGGPTVKDSKRESNFKTKEETDEKRGQFSLVVGGLLVIAFVVPMAQYFAYVSRK
Protein: Kinetoplast polyadenylation/uridylation factor 2 (Q381Z9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 30S Ribosomal protein S17, putative
- Large ribosomal subunit protein uL3m
- Kinetoplast polyadenylation/uridylation factor 1
Sequence:
MFACRRLLGLTAVGAPTHVRFNHSNNSTESTRDTDKTAASVGDPSKVVSSDSAQKLNLSLRLTDADFGAMVKATKAAMAKERLWRDLTVGSEVDISSESGPNVAIIPKHTVLPKPLGDRSSCFTTVAAEPQGARVDLSGDTRDNVLGNDNPMSSTVTSAVQDRTLTPGVRYGLMDTLRDCLISGDWPKSMRMFESAIQTACNNGKGAETSFTAMRSSDSVINNEMLEGLHRFNATTPVGSFAMNLERYRGILRWSGGHYYLLMKLLLSRHRIEEVERVWDVMKRIGYVEYRMNERTCNQLIALCRTDTKQDIVSPLLHPTKETHNREKEFRTSLVLELENWAEKKHVTLSGRNETTARVARVAHMLRSEGSKDGKDEAVGSIGHGLRVGDFSGLLRRCNSEESTARVLQMMEKLNVPRDGQIYSALIAALRQPHYQLCGSEENLSQSDGTKEAYDAHRKRRLKRARQWYDECPEESRTIDVCNEMLLITRGGSAEDVDYANLLTDIRGTPLTILGSDDTGSDTIAFSKNEGRSRPQIPVPRWRIPPNGRTYEVMVLHCRHHEEWPVVWALYDEMMERNVKGTQRLYQMLLEIVQRHPPCGRDRNTVVLELYEDMKRFGLDVTDIKSTASVVNSWCATRRKRRW
Protein: RNA polymerase-associated protein Rtf1 (dRtf1) (Q9W261)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in transcription-coupled histone modification. Required for methylation of 'Lys-4' of histone H3. Plays a role in regulation of transcription. Required for maximal induction of heat-shock genes. Plays a role in Notch signaling in the wing margins.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:16354696}. Chromosome {ECO:0000269|PubMed:16354696}. Note=Co-localizes with Paf1 and RNA polymerase II on transcriptionally active sites on chromosomes.
Interaction partners:
- Hyrax
- Ctr9, isoform A
- Uncharacterized protein
- Transcription elongation factor SPT5
- Transcription elongation factor SPT4
- Transcription elongation factor SPT6
- RNA polymerase II-associated factor 1 homolog
- FACT complex subunit spt16
- FACT complex subunit Ssrp1
- Chromodomain-helicase-DNA-binding protein 1
Sequence:
MGKRRTQSLIDSNSSDSDSESETNLESDLMSLAKKRKKPQTAAKSSSRSDSDSDWANNKAGAPSSKKKKRQKPSRDSSSSESNWDDDSQDERQPARQSPAQTQQEHKPPEQASQPAQLSEQEEGEVSDSDSDKSKSNSSSSGSDSSSSSSSSDSEFDDGFDDDLMGDDEDRRRLNGLSEKERETEIYKRIEQREIMRTRWEIERKLKLARRGEKNQEKSKNKGERAKKKKEKREKKARKAREAQAPLPTQASTSTLLDVEPKPSNEVRSASPLSTPALNRDAASTSAAVASIMPDDAASSAGVSDYFDHKERSKERKKNVEANKTDDKRSNAMALLKAKREGKAKREEEEAKRMAEKDRDDDKEELDSVSGCKSAVKLKASEIYSDDSGSSDWDEEEKPAGKRSRSNSSKASSESEDEEKAPQRPVFITTREDLNKLRLSRYKMERFVNLPIFESTVLNCFVRISIGNNGQKPVYRVAEIVGVVETGKIYSLGTTRTNRGLRLKHGTQERVFRLEFISNQEFTENEFNKWNEVCQQSHVQMPTIDLIAIKQNDIKKALNYEFKDEDVDKIVEEKNRFRNRPTNYAMKKTCLMKERDAAMLRGDYDIAQDLGQQIDELENRASELDKRRSHTLNLISYINDRNRKKNVEDAEKAILEEARANKGLKISDPFTRRITQPRMGFKGAKKDEDDMQLAPLPPPPPGKKRPNEAGTSSASVRSTDSKDYSLYSLHDFDIDLDVPLPVNTNSVPKPASKPAETVSKRSLNLEDYKKKRGLI
Protein: Response regulator EraR (Q9I2C7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- histidine kinase
- histidine kinase
- Quinoprotein ethanol dehydrogenase
- histidine kinase
- Oxygen sensor histidine kinase NreB
- Uncharacterized protein
- Probable lipoprotein
- Cytochrome c550
- Probable major facilitator superfamily
- PqqA peptide cyclase
Sequence:
MKVLLVDDHFVVREGLAALLRGLLPDVEVNEAGDGEEALQAVQREIPSLVIVDLGLPGISGLELTRRLRQRLPQLRVLFFSLHDELALVRQALDAGARGYVTKRAAPTVLLEAIRRVLAGQLYLEQPLATRLACQSWEEQGGAALRGLTRREFEIFRLLARGLALREVAEHLGVSAKTVSNHVSLLKQKLQVSTQAELVHRAIDSGVLRLGLPLPLAEEARGSLG
Protein: Putative RNA-binding protein Luc7-like 2 (Q9Y383)
Organism: Homo sapiens (Human)
Function: May bind to RNA via its Arg/Ser-rich domain.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q7TNC4}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TNC4}. Note=Colocalizes with SCNM1 and SNRNP70 in nuclear speckles. {ECO:0000250|UniProtKB:Q7TNC4}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- U1 small nuclear ribonucleoprotein 70 kDa
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein E
- Splicing factor U2AF 65 kDa subunit
- Putative RNA-binding protein Luc7-like 1
- Sodium channel modifier 1
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein F
Sequence:
MSAQAQMRAMLDQLMGTSRDGDTTRQRIKFSDDRVCKSHLLNCCPHDVLSGTRMDLGECLKVHDLALRADYEIASKEQDFFFELDAMDHLQSFIADCDRRTEVAKKRLAETQEEISAEVAAKAERVHELNEEIGKLLAKVEQLGAEGNVEESQKVMDEVEKARAKKREAEEVYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIEIREKLEELKRVVAEKQEKRNQERLKRREEREREEREKLRRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRSRHSSRDRSRERSKRRSSKERFRDQDLASCDRDRSSRDRSPRDRDRKDKKRSYESANGRSEDRRSSEEREAGEI
Protein: GEO12017p1 (Goddard) (IP04252p) (Q9VUG4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Degringolade, isoform A
- Tropomyosin-1, isoforms 9A/A/B
- IP06556p
- Testis-enriched HMG-box-containing protein 2, isoform B
- Protamine A, isoform A
- FI08029p
- AT22380p
- Testis-enriched HMG-box-containing protein 1
- Uncharacterized protein
- GEO12122p1
Sequence:
MSDDGSDIFQDLESYEPYTEGSQNNSDEATAVGPLDTSEDARFSEQVFSNIQERLNRIINRISMANSAVVQMKRKLHARIPSVPVGENADQLAGGDNPMRFENVEQENETTNQ
Protein: UPF0642 protein C32H8.05 (Q96WW3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ribosome biogenesis protein nsa2
- Ribosome biogenesis protein rlp24
- Uncharacterized RNA-binding protein C1827.05c
- 60S ribosome subunit biogenesis protein nip7
- Probable rRNA-processing protein ebp2
- Protein mak16
- Large ribosomal subunit protein uL3B
- Large ribosomal subunit protein uL3A
- Ribosome biogenesis protein brx1
- Ribosome assembly factor mrt4
Sequence:
MAKSARSKSIRRNKKVLRENVFQPVIDERTKRLSAHLRDQVNDLTKSSSSKEEGIADNSLKEVSSSEVSDNVGMEVDQPKVSTSGPRDNNRNKWAKKHLKKGKRAKNSNFSKFLKKK
Protein: Two-component response regulator (Q9I529)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- histidine kinase
- Sensor protein PfeS
- Transcriptional activator protein PfeR
- histidine kinase
- histidine kinase
- HTH gntR-type domain-containing protein
- Probable transcriptional regulator
- Probable transcriptional regulator
- histidine kinase
- Sensor protein
Sequence:
MFPSLTPDPRLLAIEDDPTLGAHLFQHLNGSGFEVTWCRDGEEGLAAARSGGYDLILMDIMLPGRDGLEILRQLRQEQALPVILMSALGAEQDRIAGFSQGADDYLPKPFSLAELRVRIDAILRRIALERGGAPGRCAEPLARPSLQFSADVCDVSLGERFAGLTPTEYRLLETFLAAEGETLTKAFLYQHVLHRGHTQHDRSLDMHVSHLRRKLQRLGYAGHQLHTVWGKGYVLTPAP
Protein: Lactamase_B domain-containing protein (O62162)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MMSTSSSVLPTTPIGKQQVIDLKAGAILRENARKSVLFFGCPLSVVLVLIVLIKCLCISFWIIREHETFDFRCAAWNGGQPTDYMYRAKRSIAFEKSDPRKFSKIPDDDDDDNSKTDVINKKDKKKKPLYGRSTSPANDIISDAPKIDPRLDFGPLPPNFQRKIDSNHIPAVPPYEPDDDLPMTTMVTLTNTQIVQLSGEETGVVKMKTIRNRVEKVGSDEEQFIEIDIANAPRIYVSKIKSRHGGEEEEHFDLLKELKKDEEEKEKKKEKKKKGKGLKKAKKLTEAEKLLNNSTSTSVIPDTAVSRKPKGKGLKKSKKLNQKPKSDEEVTKQPRHLVGKSSSLSPTTPRPKSSWMNGVLDPQDPNFSNQGQIRGYPMQKASRKPSATTASPSEKDEDEEKLKLSESTRMMWDMDELKYTTFLAPKTTEQTKQVEEGVKEVIQEAHERSQKPMLKETFEEATTSTEKPLPGGMSKDQWEKKKEAFEAYTPPISLSDLQPSHSSHSGPAQAPQHIHFESASSTPSTPPAFHFIPPSSEAPYYVEINDADTETVYVSSVTPMYRPVFENMGHLESTTKSYDPLHLEMEIAKLKESSTCLARMAFDVWCLFVLFSTVPFIMGICVPRWSLFVLHIVFDFLFLVVGFVTSLTIAIMSSIMYFLIDEMTSDSLFEFLLVAFVIDIVLILYAIVVGIAYRCCCRLVDNSIKETSINYSVSSNGEAV
Protein: O-antigen ligase (EC 2.4.99.26) (Surface polymer:lipid A-core ligase) (P27243)
Organism: Escherichia coli (strain K12)
Function: Adds the O-antigen on the glucose group of LPS.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:19019161, ECO:0000269|PubMed:30047569}; Multi-pass membrane protein {ECO:0000269|PubMed:19019161, ECO:0000269|PubMed:30047569, ECO:0000305|PubMed:15919996}.
Interaction partners:
- Lipopolysaccharide heptosyltransferase 2
- Lipopolysaccharide heptosyltransferase 1
- Putative lipopolysaccharide heptosyltransferase 4
- UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
- Putative O-antigen transporter
- Lipid III flippase
- Lipopolysaccharide biosynthesis protein WzxC
- ADP-L-glycero-D-manno-heptose-6-epimerase
- Lipopolysaccharide 1,2-glucosyltransferase
- Lipopolysaccharide glucosyltransferase WaaO
Sequence:
MLTSFKLHSLKPYTLKSSMILEIITYILCFFSMIIAFVDNTFSIKIYNITAIVCLLSLILRGRQENYNIKNLILPLSIFLIGLLDLIWYSAFKVDNSPFRATYHSYLNTAKIFIFGSFIVFLTLTSQLKSKKESVLYTLYSLSFLIAGYAMYINSIHENDRISFGVGTATGAAYSTMLIGIVSGVAILYTKKNHPFLFLLNSCAVLYVLALTQTRATLLLFPIICVAALIAYYNKSPKKFTSSIVLLIAILASIVIIFNKPIQNRYNEALNDLNSYTNANSVTSLGARLAMYEIGLNIFIKSPFSFRSAESRAESMNLLVAEHNRLRGALEFSNVHLHNEIIEAGSLKGLMGIFSTLFLYFSLFYIAYKKRALGLLILTLGIVGIGLSDVIIWARSIPIIIISAIVLLLVINNRNNTIN
Protein: Alpha N-terminal protein methyltransferase 1 (EC 2.1.1.244) (Translation associated element 1) (X-Pro-Lys N-terminal protein methyltransferase 1) (NTM1) (O13748)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Probable MRF1 mitochondrial N
- Protein arginine N-methyltransferase 2
- Protein-lysine N-methyltransferase efm4
- tRNA wybutosine-synthesizing protein 2
Sequence:
MDPEKFYSDAIDYWNGVQPTVDGMLGGLGTGRIPQTDVVGSRTFLNRLNYRIGKIENLVAADCGAGIGRVTENVLLKIASHVDLVEPVENFISTAKKQLATKPCSFINVGLQNWTPEKNRYGLIWNQWCLSHLTDEDLIAYLSRCCEAIQEKGVICVKENVSSFEDTFDPIDSSVTRCEQSLKSLFKKANLVVVAETLQHGFPEELFPVKMYALVPHSS
Protein: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase GtfA subunit (EC 2.4.1.-) (Glycosyltransferase GtfA) (O-glycosyltransferase) (Q9AET5)
Organism: Streptococcus gordonii
Function: Required for polymorphic O-glycosylation of GspB, a serine-rich repeat cell wall protein encoded upstream in the same operon. Catalyzes the first step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to serine residues in GspB. Part of the accessory SecA2/SecY2 system specifically required to export GspB. Upon coexpression in E.coli with GtfB glycosylates GspB constructs. Glycosylation probably occurs intracellularly. Requires GtfB for glycosylation activity, it has no activity alone. Does not use UDP-glucose as substrate. Has a fast, probably processive glycosylation phase followed by a slower, non-processive phase. The enzyme probably modifies its tertiary conformation by opening and closing its intersubunit interfaces to accomodate the increasingly glycosylated substrate; protein substrate recognition is provided by GtfB.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01472}. Cell membrane {ECO:0000255|HAMAP-Rule:MF_01472}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01472}. Note=Cell membrane association requires GtfB. {ECO:0000255|HAMAP-Rule:MF_01472}.
Interaction partners:
Sequence:
MTVYNINLGIGWASSGVEYAQAYRAQILRRIQQPAKFIFMDMILADNIQHLTENIGFLDEEIIWLYNYFTDIKIAPTTVTLDQVLAQVAGQPERSEKEGKIVRYFYPQDDQFITCYLRQEDQDSVEHVEYVSRGRLIRKDYFSYVRYASEYFAPHNDAATLYQRRFYHEDGSVAYDMLIEDGQEKLYRFPDRIFYSKAELVRYFLQCLQLQADDVVILDRETGIGQVVFEESQKAKLGVVVHAEHFSENASSDDYILWNNFYDYQFTNADKVDFFIVATEAQKRILEQQFQHYSDKQPQIATIPVGSLDQLTYPKEPRKPYSMITASRLATEKHIDWLVAATVQAHAQLPELTLDIYGKGSEEDKLRRRIEEAGAQDYIRLKGHADLSQIYAGYELYLTASTSEGFGLTLMEAVGSGLPLIGFDVRYGNQTFIDDGKNGYLLPVSSNHVEDQIIAAFVEKIIALFSQGRQQEMSQHSYQVAENYLTSRVEAAWTQLLKEVRDDSAL
Protein: Mitotic cohesin SCC1 (Q9U6D9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPKVKLALRTSGHLLLGVVRIYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEGHREANVNAITLPEVFHDFDTALPELNDIDIEAQFSINQSRADEITMREDYGSLSLSLQDDGFGDIGFEAETPEIIRCSIPSNINDKIFDNDVLENIESLDPHSLDAHADMPGSRLDGDGFGDSFGQPALFEDDLFGDPSQPVEQITKESTTVLNADDSDEDAIDNIHNVPSPATSLVNSIEDEKEENNLNGHASVSENVPMNEITLVQNEDEGFALRPLDVSMYKGVTKAKRKRKLIIDEIKNISGEEMKAQLADTSDILTTLDLAPPTKRLMYWKETGGVEKLFSLPSRSIPARALFGNYNRQLFSHSTFFEDFSSVVPMEILALEFYTKENENALIIFNKKGRKRKNDNMSNLFLDHVPDSVVQSLEAPEVLRANHKSLGVSTVSVEIVSKEQESISCQNELTFFDNMRSPDLLSLNEMEQFSSINELPLTPRNMNHEMGDDFNQGDSTPAGLDHGHATPQHGNIGEMDHDSVIPTKKTAVILNESVGTSVLSDNGVSKRTNNILKGWDNYEIPSFVGQNHGDEQMENETDEQFEERVLNKRAAHLFIDVRAHFIAKDSLELSQLTSGNSRKQAAQKFYSLLVLKKFKVLHIDQSAPYADITITRGPTFENPKI
Protein: Chloride channel protein clh-3 (Q9BMK9)
Organism: Caenorhabditis elegans
Function: Voltage-gated chloride channel. Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus. Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. When active, may prevent tubular formation of the excretory canals. Activated during oocyte meiotic maturation and by membrane hyperpolarization and cell swelling. Inhibited by Zn(2+) and to a lesser extent by Cd(2+).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10567397, ECO:0000269|PubMed:11078724, ECO:0000269|PubMed:11231150, ECO:0000269|PubMed:12163466, ECO:0000269|PubMed:14565992, ECO:0000269|PubMed:15684092, ECO:0000269|PubMed:16500974, ECO:0000269|PubMed:19088383, ECO:0000269|PubMed:20581474, ECO:0000269|PubMed:23083714, ECO:0000269|PubMed:24431435}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Germinal center kinase 3
- Clc-like protein 2
- Serine/threonine-protein phosphatase
- Solute carrier family 12 member 1
- Serine/threonine-protein kinase WNK
Sequence:
MGIGTKILSKIEKNKTSDGLTIPLTPTTQKQSSSWCSFESIKTFFRTVIRDWIFLALLGFIMASLSFGMDYAILNLQNGQMRLFDLVKEYHFTLAYLVWVGYVVGLILLSAVCAHYIAPQAIGSGIPEMKTILRGVILKEYLSVRTLLSKMIGLTLSLGSGLPMGKEGPFVHVASVVASQLTRLVHGSSGGIFENESRSGEMLAAGCAVGVACTFSAPIGGVLFSIEVTSVYFAVRNYWRGFFAATCSATLFRILRMFSVSAAVTVEAHYQTNFPPQNVFLPQELPIFALIGLVCGLAGSIFVYLHRRTVLFLRRNWLAKMIFQKYWLIYPIFIATFISSLSFPLGLGKFMGGEERFSHTMKEFFVDCAWTAPPNDSYACPMPTSNATSSDSFDIRHWKGDNYDYSPFVTLSSFQVVYFFLAILASTLPVPSGIFMPVFVLGAAFGRLVGEGVFSLDPYGHISGDIQFFVRPGVYAVVGAAAFCGAVTHTVSVAVIVFELTGQLCHLLPVMIAVLIANAVASYLQPSIYDSIIRIKNLPYLPDIPHTTSLYHQMLIEQFMISPLVYIAKDSTVGDIKRALETKTRIRAFPLVENMESLALVGSVSRSQLQRYVDSQIGTKARFAEATRRIKQRLEDEESERKRREESKSDDTEDSLETTGAGERRASRFLIVPVAKNGPQVAKNETLTGLSEENARKILTVEEKQALFDAASLATPKREMSGKTINPVHIESHHTIGDIFRSITHLSFGRQNFPKKNNHNEFDLFGEERTEWEDMMLNQKLDLSQLDIDSTPFQLSEYTSLFKAHSLFSLLGLNRAYVTKKGQLIGVVALKELRLAIEYLQSGKVPTPGMSIFNEPPTEQSIYEKSARLESGRATGDAQNAAFVTDNGEDDAQNDYIQPPLEVVRRGALTPNRMSELTRLENVRTTPESPHFEVSSPSTSSSCVSIDFSPLDAANSENGSVGGLVLNVPSLPTRARSANELTRQNTHVQINLPDDVHDEKF
Protein: Dihydroorotate dehydrogenase (fumarate) (DHOD) (DHODase) (DHOdehase) (EC 1.3.98.1) (Dihydroorotate oxidase) (P28272)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. Does not use oxaloacetate or NAD or NADP as electron acceptors.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1409592}.
Interaction partners:
- Dihydroorotase
- Orotate phosphoribosyltransferase 1
- Orotidine 5'-phosphate decarboxylase
- Orotate phosphoribosyltransferase 2
- Protein transport protein GOT1
- Pyrimidine pathway regulatory protein 1
- Multifunctional protein URA2
- Probable NADPH:adrenodoxin oxidoreductase, mitochondrial
- Cytochrome c mitochondrial import factor CYC2
- Plasma membrane-associated coenzyme Q6 reductase PGA3
Sequence:
MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI
Protein: Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (SET domain bifurcated 2) (Q06ZW3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. During early development, required to specify the left-right axis by repressing expression of FGF8, leading to negatively regulate the dorsal organizer formation.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- SET domain and mariner transposase fusion protein.
- ADP-ribosylation factor-like 14 effector protein
- PHD finger protein 11.
Sequence:
METEADTAKTFWSEVDVDGVFDELMEVLRRLRHTLRHNTATDREYVQAMRIVQESKLIRTETEDVLLDEDILTVTVSEPQCSPESLQNGIEPEDPQHSTARLYSDVGVVCSHMSSSRPDPAAPLVFQPHVCSSACVPHLPAHTHHLLGHNPLRAPLLCHFQRVCDDAGVVYKAPCGRSLSCMQEVLHFLLQTQSVCVLQTDRFSFSTQVCVERQVCAAPLLERDLSRGLEPVPVALVNTVDGARPREFRYRRERWPHGCFLSAEPLYSVCCDCTDGCTDAHSCACVRRTAGAAYTHQRLTHTLRTGLFECGPWCGCERSRCENRVVQKGLRVRLQVFRTPEHMWAVRCRDDLDAGTFICIYAGVVLRLQQSSECPAERSGEPAVSDDEVQLVEEWRIPEETHTHTHTLDSSPPLHVPVIQRPAEHSLAQRRDQQQFSISSETEDNRCEQALRKKPRLMESNGLQDSRTHTLTHTHDGVYYLDASREGNVARFFTHSDDPNLFIQNVFTDTHDPQFPLIAFFTCRPVKAGTELTWSCTNTEQQKTEEKHCSV
Protein: (E2-independent) E3 ubiquitin-conjugating enzyme FATS (EC 2.3.2.-) (Centrosomal protein C10orf90 homolog) (E2/E3 hybrid ubiquitin-protein ligase FATS) (Fragile-site associated tumor suppressor homolog) (FATS) (D2J0Y4)
Organism: Mus musculus (Mouse)
Function: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. May have a role in the assembly of primary cilia (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96M02}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96M02}. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q96M02}.
Interaction partners:
Sequence:
MISPVVISRLIDEKKSMENGAILPQAIAQPQLCPTKPALARRDGVSMHRRFALSPDRLGILTPSDDQGLETEPLSTGDNLGKGSHSGFSSITITARRVGPPASSLVWDTFRDPLCPKCKAKDALFQEPPVLAGDAHLCQHNRPFTCTESPSNGSVEGMKVFQAHSRLSARQDYWVTHTNDNEDSFSSDNSPSRKVPLVFSSCVHFRVSQQCPNAIYYLDKSLSVPLERPQIASPKMHRSVLSLSLRCSSHQLTADGVDSSANGEPISTALSQELSEGKQDLLGPQWGQPQGGHWKESPALVPVHLGSGTCPRTGSPPLENVKFADVGRNQVPVRKEKEDHATCTSSSHTNQLSIHIPGWSYRAETKVLSGSKKQQQEAQRTLPAFPVGQKTIKHFPPEGDSSPSSDGQPSILSESNERQHPYFMIPRVPLPGFYCPLQTGCASLQEDGAVQIETHFPKDYTCCDLVVKLKECEKNEDPTVTPEPSPATPSPSTPEGAQSSDPSEDSYEPLLASSMTLQEALEVHRPQFISRSQERLQKLKRMVQQRKTQQKESLGQKQSLLPVRANKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYNNLPEVKKKKEEQKKRMILQSNRLRAEVFKKQLLDQLLQRNAV
Protein: Dahlein-5.3 (P84269)
Organism: Ranoidea dahlii (Dahl's aquatic frog) (Litoria dahlii)
Function: Has no antimicrobial activity. Strongly inhibits the formation of NO by neuronal nitric oxide synthase at micromolar concentrations.
Subcellular location: Secreted {ECO:0000269|PubMed:11555873}.
Interaction partners:
Sequence:
GLLASLGKVLGGYLAEKLKP