wanglab/gogpt-training-data huggingface dataset:
Protein: DNA-binding transcriptional activator AlpA (Prophage CP4-57 regulatory protein AlpA) (P33997)
Organism: Escherichia coli (strain K12)
Function: Positive regulator of the expression of the slpA gene. When overexpressed, leads to suppression of the capsule overproduction and UV sensitivity phenotypes of cells mutant for the Lon ATP-dependent protease. Part of the cryptic P4-like prophage CP4-57. Overexpression of AlpA leads to excision of the CP4-57 prophage by IntA. This inactivates ssrA (the gene upstream of the prophage) that encodes tmRNA which is required to rescue stalled ribosomes in a process known as trans-translation.
Interaction partners:
- Putative type II secretion system protein M
- DNA utilization protein HofQ
- Protein transport protein HofB homolog
- Protein transport protein HofC homolog
- Prophage Rz endopeptidase RzpD
- Prophage integrase IntA
- Type II secretion system protein H
Sequence:
MNNRSAVRILRLPAVIQKTGMARATIYDWLNPKSPRYDATFPKKRMLGVKSVGWIEAEIDEWLSQRCKLI
Protein: Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) (Q9JIR0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O95153}. Mitochondrion {ECO:0000250|UniProtKB:O95153}. Note=Preferentially expressed in the mitochondria in the presence of TSPO. {ECO:0000250|UniProtKB:O95153}.
Interaction partners:
- Translocator protein
- Regulating synaptic membrane exocytosis protein 1
- Regulating synaptic membrane exocytosis protein 2
- Protein unc-13 homolog B
- PTPRF interacting protein alpha 2
- Liprin-alpha-4
- Syntaxin-1A
- Protein lin-7 homolog B
- Ras-related protein Rab-3A
Sequence:
MEQLTTLPRLGDPGAMEPWALPAWQHWTQGQGCKPGDASASIAATPTALQVKGLRFEESSEPAGAHSPGPIRNTDPEGTETVLPKLGQQAESPGYSCSRLEGEDAQAYKAKFNIGFGDRPNLELLRALGELQQHCTILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERAQKLQETNMRGGEVPLCPDPDPVWSCARKALARQRARDLSETATALLAKDKQNAALQRECRELQARLSLVGKEGPQWLHMRDFDRLLRESQREVLRLQRQIALRNQREPLRPARSQGSTAPSSVGAPAPGAPGETVLEDDVESPQVVLGEPEKQLRVQQLESELCKKRKKCESLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGKATEKEQVEWENAELKGQLLGVTQERDSALRKSQGLQSKLESLEQVLEHMRKVAQRRQQLEEEHEQARLSLQEKQEEVRRLQQAQAEAKREHEGAVQLLESTLDSMQARVRELEGQCRSQTERFSLLAQELQAFRLHPGPLDLLTSALGCNALGDHPPPHCCCSSPQPCQGSGPKDLDLPPGSPGRCTPKSSEPALATLTGVPRRTAKKAESLSNSSRSESIHNSPKSCPTPEVDTASEVEELEVDSVSLLPAAPEGHSGGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLSTLPRELADSSHSSGPELSFLSGGGGGCSSGGQSSGGRSQPRPEEEATGDELSLSPPPEGLGEPLAVPYPRHITVLKQLAHSVVLAWELPPERVDLRGFHIFVNGELRQALGPGVPPKAVLENMDLRAGPLHVSVQALTSKGSSDPLRCCLAMGAGAGVVPSQLRIHRLTATSAEITWVPGNSNLAHAVYLNGEECPPARPSTYWATFCNLRPGTLYQARVEAQIPSQGPWEPGWERPELRAATLQFTTLPAGLPDAPLDVQAEPGPSPGIVMISWLPVTIDAAGTSNGVRVTGYAVYADGQKIMEVASPTAGSVLVEVSQLQLLQACHEVTVRTMSPHGESTDSIPAPVAPALASACQPARMSCLSPRPSPEVRTPLASVSPGLGYTSLPLRHPVPHGTQDSPASLSTEMSKGPQEEPPVPCSQEEAGSAVHRTSEEKRAMEPTLGQEGPDPVAPFLAKQAVECTSGDAGPTPCSTQEELTQKEPSTEVCHRGDLDSELKLRSEKEGMSELGVHLVNSLVDHSRNSDLSDIQEEEEEEEEEEELGSRPWSFQKQVAGNSIGENGAKPQPDPSCETDSDEEILEQILELPLQRLCSKKLFSIPEEEEEEDEEEGLGKPGPSSSSQDPSQPERALLGLDCESSQPQGPGLCPLSPELSGAREHLEDVLGVVGGNSRRRGGCSPEKLPNRKRPQDPREHCSRLLGNGGPQTSARPVPPRDRGSLPVIEGTRVGQEPGGRGRPGLSRRCPRGPAPESSLVSCLSPKCLEISIEYDSEDEQEVGSGGVSISSSCYPTDGEAWGTAAVGRPRGPVKVNSGSNTYLRLPAWEKGEPERRGRSAIGRTKEPPSRATETGESRGQDNSGRRGPQRRGARVLRTGTTELAPPRSPQEAPSHQDLPLRVFVALFDYDPISMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGESGGRTGYIPCNMVAEVAVDTPTGRQQLLQRGFLPPNVLTQGSGNGPSVYPSAHTPGPPPKPRRSKKVELEDPAQLCPGPPKLIHSAALKTSRPMVAAFDYNPRENSPNMDVEAELPFRAGDVITVFGNMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDSGTSQAESQRTRRRRVQC
Protein: NFKB activating protein (A0A494C050)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XAPVSGSRSPDREASGSGGRRRSSSKSPKPSKSARSPRGRRSRSHSCSRSGDRNGLTHQLGGLSQGSRNQSYRSRSRSRSRERPSAPRGIPFASASSSVYYGSYSRPYGSDKPWPSLLDKEREESLRQKRLSERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEPKKSTTSASTSEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSDEDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQEEFLENPWKDRTKAEEPSDLIGPEAPKTLTSQDDKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMVYRKTKGKDDK
Protein: Anti-sigma-28 factor FlgM C-terminal domain-containing protein (O25747)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- Alternative transcription initiation factor, sigma-F
Sequence:
MNIKLKDFTMINAVSSLAPVQSLGNYKRVEKNEKVENNEAALDRVAEIKKAIENNQYKINLHETSHKMAKDLLGIS
Protein: Delta-guaiene synthase 1 (EC 4.2.3.87) (EC 4.2.3.93) (D0VMR6)
Organism: Aquilaria crassna (Eagle wood)
Function: Sesquiterpene synthase involved in the biosynthesis of delta-guaiene (81.2%) and alpha-guaiene (18.1%), two structures composed of five- and seven-membered rings. Produces also 0.7% of alpha-humulene.
Interaction partners:
Sequence:
MSSAKLGSASEDVNRRDANYHPTVWGDFFLTHSSNFLENNDSILEKHEELKQEVRNLLVVETSDLPSKIQLTDEIIRLGVGYHFETEIKAQLEKLHDHQLHLNFDLLTTSVWFRLLRGHGFSISSDVFKRFKNTKGEFETEDARTLWCLYEATHLRVDGEDILEEAIQFSRKKLEALLPELSFPLNECVRDALHIPYHRNVQRLAARQYIPQYDAEPTKIESLSLFAKIDFNMLQALHQRELREASRWWKEFDFPSKLPYARDRIAEGYYWMMGAHFEPKFSLSRKFLNRIIGITSLIDDTYDVYGTLEEVTLFTEAVERWDIEAVKDIPKYMQVIYTGMLGIFEDFKDNLINARGKDYCIDYAIEVFKEIVRSYQREAEYFHTGYVPSYDEYMENSIISGGYKMFIILMLIGRGEFELKETLDWASTIPEMVEASSLIARYIDDLQTYKAEEERGETVSAVRCYMREFGVSEEQACKKMREMIEIEWKRLNKTTLEADEISSSVVIPSLNFTRVLEVMYDKGDGYSDSQGVTKDRIAALLRHAIEI
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q8L7S7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- U-box domain-containing protein 52
- U-box domain-containing protein 34
- U-box domain-containing protein 51
- Probable E3 ubiquitin-protein ligase ARI3
Sequence:
METAKAWLSKLKSKDKVKSSKKKEATSNVKEGPKTAGGEEALSNITKEKAAAAKLYIENHYKMQMQSLQERKERRKMLEKKLAAAEVSEEEQNNLLKDLEMKETEYMRRQRHKMGADDFEPLTMIGKGAFGEVRICREKGTGNVYAMKKLKKSEMLRRGQVEHVKAERNLLAEVDSNCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDTLTEDEARFYIGETVLAIESIHKHNYIHRDIKPDNLLLDKDGHMKLSDFGLCKPLDCSNLQEKDFTVARNVSGALQSDGRPVATRRTQQEQLLNWQRNRRMLAYSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLVGFPPFYSDDPMTTCRKIVNWRNYLKFPDEVRLSPEAKDLICRLLCNVEQRLGTKGADEIKGHPWFRGTEWGKLYQMKAAFIPQVNDELDTQNFEKFEETDKQVPKSAKSGPWRKMLSSKDINFVGYTYKNVEIVNDDQIPGIAELKKKSNKPKRPSIKSLFEDETSGGTTTHQGSFLNLLPTQIEDPEKEGSKSSSSG
Protein: Transcription factor Sp2 (Q02086)
Organism: Homo sapiens (Human)
Function: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Subcellular location: Nucleus.
Interaction partners:
- DNA-directed RNA polymerase, mitochondrial
Sequence:
MSDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLSASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTPSGEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL
Protein: Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) (Q9P2E9)
Organism: Homo sapiens (Human)
Function: Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEVPMVVVPPVGAKGNTPATGTTQGKKAEGTQNQSKKAEGAPNQGRKAEGTPNQGKKTEGTPNQGKKAEGTPNQGKKAEGTPNQGKKAEGAQNQGKKVDTTPNQGKKVEGAPTQGRKAEGAQNQAKKVEGAQNQGKKAEGAQNQGKKGEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGQKGEGAQNQGKKTEGAQGKKAERSPNQGKKGEGAPIQGKKADSVANQGTKVEGITNQGKKAEGSPSEGKKAEGSPNQGKKADAAANQGKKTESASVQGRNTDVAQSPEAPKQEAPAKKKSGSKKKGEPGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLLSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGTSV
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q8MKK7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRIRSNPMPSRMVDILCFLIIAVFLPVVFMFEIVVVLPAFHEPGGFFHTFTFLMAMFLVFNIKGNMIACMMIDTSVNVKKVEPPSDQLNWRECGECQKLAPPRSWHCKACKVCILKRDHHCIYTGCCIGLRNHRFFMGFIFYLFVGSVYALVYNSIYMWVIHGHIYSNWVTVLKLACPMLHLLWLMESSSWPTMCPLF
Protein: Dapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein) (Q9NYF0)
Organism: Homo sapiens (Human)
Function: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.
Subcellular location: Cytoplasm. Nucleus. Synapse {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence.
Interaction partners:
- Segment polarity protein dishevelled homolog DVL-2
- Segment polarity protein dishevelled homolog DVL-1
- Vang-like protein 2
- Segment polarity protein dishevelled homolog DVL-3
- Catenin beta-1
- SEC14 domain and spectrin repeat-containing protein 1
- Vang-like protein 1
- Catenin delta-1
Sequence:
MKPSPAGTAKELEPPAPARGEQRTAEPEGRWREKGEADTERQRTRERQEATLAGLAELEYLRQRQELLVRGALRGAGGAGAAAPRAGELLGEAAQRSRLEEKFLEENILLLRKQLNCLRRRDAGLLNQLQELDKQISDLRLDVEKTSEEHLETDSRPSSGFYELSDGASGSLSNSSNSVFSECLSSCHSSTCFCSPLEATLSLSDGCPKSADLIGLLEYKEGHCEDQASGAVCRSLSTPQFNSLDVIADVNPKYQCDLVSKNGNDVYRYPSPLHAVAVQSPMFLLCLTGNPLREEDRLGNHASDICGGSELDAVKTDSSLPSPSSLWSASHPSSSKKMDGYILSLVQKKTHPVRTNKPRTSVNADPTKGLLRNGSVCVRAPGGVSQGNSVNLKNSKQACLPSGGIPSLNNGTFSPPKQWSKESKAEQAESKRVPLPEGCPSGAASDLQSKHLPKTAKPASQEHARCSAIGTGESPKESAQLSGASPKESPSRGPAPPQENKVVQPLKKMSQKNSLQGVPPATPPLLSTAFPVEERPALDFKSEGSSQSLEEAHLVKAQFIPGQQPSVRLHRGHRNMGVVKNSSLKHRGPALQGLENGLPTVREKTRAGSKKCRFPDDLDTNKKLKKASSKGRKSGGGPEAGVPGRPAGGGHRAGSRAHGHGREAVVAKPKHKRTDYRRWKSSAEISYEEALRRARRGRRENVGLYPAPVPLPYASPYAYVASDSEYSAECESLFHSTVVDTSEDEQSNYTTNCFGDSESSVSEGEFVGESTTTSDSEESGGLIWSQFVQTLPIQTVTAPDLHNHPAKTFVKIKASHNLKKKILRFRSGSLKLMTTV
Protein: Rae1 protein homolog (mRNA-associated protein mrnp 41) (Q7ZZY7)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cytoplasm, cytoskeleton, spindle pole {ECO:0000256|ARBA:ARBA00004647}.
Interaction partners:
- Uncharacterized protein.
- Nuclear RNA export factor 1 isoform X1
- Uncharacterized protein.
- Nuclear pore complex protein Nup85
- Nuclear pore complex protein Nup155
- Nuclear pore complex protein
- Nuclear pore complex protein Nup153
- Uncharacterized protein.
- Uncharacterized protein.
- Rae1 protein homolog
Sequence:
MTLFSTPGGFGTGGGSMFGSTATDNHNPMKDIEVASPPDDSISCLSFSPQTLPGNFLIAGSWANDVRCWEVQDNGQTIPKAQQMHTGPVQDVCWSDDGTKVFTASCDKTAKMWDLNSNQSIQIAQHDAPIKTVHWVKAPNYSCIMTGSWDKTLKFWDTRSPNPLLSIQLPERGYCADVVYPMAVVATAERGLIVYQLENQPSEFRRIDSPLKHQHRCVGIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTAAPQDIYAVNDIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPITACCFNHNGNIFAYSSSYDWSKGHEFYNPQKKNYIFLRNAAEELKPRNKK
Protein: Fasciclin-like arabinogalactan protein 1 (A9XTL6)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MMGQRQHVVLLIFSAFLLFQTSNAHNVTRLLAKHPSLSTFNHYLTLTHLAPEINRRTTITVLALDNAAMSSLLDKNPSIYTIKNILSLHVLLDYFGAKKLHQIRNGTALAATMFQATGVATGVSGFVNITDFKGGKVGFGAEDNGGSLNSFFVKSVEELPYNISVIQISKALPSVVAEAPTPGPSELNITGIMSAHGCKVFADTLLANPEAMGTYEDNVNGGLTVFCPMDDPFKAFLPKYKNLTASKKASFLEFFGVPVYQSLSMLKSNNGLMNTLATDGASKFDFTVQNEGEEVTLKTRVNTAKITGTLIDEQPVAIYTIDKVLLPKELFKAALSPAPAPAPEEAADAPKGSKSKTKSKSKTKSKAAPTPDSDSPAESPDDDPADQVADDDNAAMCFGAERLAVVGLSFLLVFFLL
Protein: Isoleucine N-monooxygenase 2 (EC 1.14.14.39) (Cytochrome P450 79D4) (Valine N-monooxygenase 2) (EC 1.14.14.38) (Q6J540)
Organism: Lotus japonicus (Lotus corniculatus var. japonicus)
Function: Involved in the biosynthesis of the cyanogenic glucosides linamarin and lotaustralin and of the nitirle glucosides rhodiocyanoside A and D. Can use L-isoleucine > L-valine as substrate, but not L-leucine, L-phenylalanine or L-tyrosine.
Subcellular location: Microsome membrane {ECO:0000250|UniProtKB:D5JBW8}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGLTPDFLSFCLEFSWTFLLVVIFFFIIFKVTKSHSVNKSKKYKLPPGPKPWPIVGNLPEMLANRPATIWIHKLMKEMNTEIACIRLANTIVIPVTCPTIACEFLKKHDASFASRPKIMSTDIASDGFLTTVLVPYGEQWKKMKRVLVNNLLSPQKHQWLLGKRNEEADNLMFYIYNKCCKDVNDGPGLVNIRIAAQHYGGNVFRKLIFNTRYFGKVMEDGGPGFEEVEHINATFTILKYVYAFSISDFIPFLRRLDLDGHRSKIMKAMGIMKKYHDPIIHDRIKQWNDGLKTVEEDLLDVLIKLKDASNKPLLTLKEIKAQITELAIEMVDNPSNAFEWALAEMLNQPELLKRATEELDNVVGKERLVQESDIPKLQFVKACAREALRLHPMEYFNVPHLCMNDTMVGDYLFPKGTQVLLSRVALGRNPKFWTDPLKFNPERHLKEGIDVVLTEPDLRFISFTTGRRSCPGVTLGTTMTIMLFARMLHGFSWSAPPNVSSIDLTQSSDDLFMAKPLCVVAKPRLAAELYSTNEFK
Protein: Ectodermal-neural cortex 3 (Enc1 protein) (Q7ZT06)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSVSNHENRKSRSSSGSMNIQLFHKTSHADSLLTHLNLLRKRRVFTDVVLRAGHRVFPCHRAVLASCSRYFEAMFSGGLKESRDAEVNFHDSLHPEVLELLLDYAYSARVIINEENAESLLEAGDMLQFHDIRDAASEFLEKNLHPSNCLGMMLLSDAHQCQRLYELSWRMCLANFANLYHTEDFLSLPKDKVQELVFSEELEVEDESIVYEAVIDWVRADIGRRHLDLPDLLRCVRLALLPETYLLKNVASEELVMGHKVGREIVEDAVRCKMKILQNDGVVTGFCARPRKVSQALLLLGGQTFMCDKVYMIDHKAKEITPKTDLPSPRKECSACAIGCKVYVTGGRGSENGASKDVWVYDTLHDEWSKAAQMLVARFGHGSAELDHILYVVGGHTSLAGSFPASPSVSLKQVEQYNPQSNKWTLVAPLREGVSNAAVVGAKNKLFAFGGTSVNRDKYPKVQCFDPCENRWTVPATCPQLWRYTAAAVVGNHVVVIGGDTEFSASSAYRFNSETFQWTKFGDVTSKRISCHAVASGNRLYVVGGYFGAQRCKTLDCYDPSTDSWDSITSVPYSLIPTAFVSTWKYLPS
Protein: DNA polymerase subunit gamma-2 (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta) (Q9QZM2)
Organism: Mus musculus (Mouse)
Function: Mitochondrial polymerase processivity subunit. It regulates the polymerase and exonuclease activities promoting processive DNA synthesis. Binds to ss-DNA.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P54098}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:P54098}.
Interaction partners:
- DNA polymerase subunit gamma-1
- Bifunctional glutamate/proline--tRNA ligase
- Twinkle mtDNA helicase
- DNA replication ATP-dependent helicase/nuclease DNA2
- Tyrosine--tRNA ligase, cytoplasmic
- Mitochondrial genome maintenance exonuclease 1
- Single-stranded DNA-binding protein, mitochondrial
- Deoxyguanosine kinase, mitochondrial
- DNA-directed RNA polymerase, mitochondrial
- Ribonucleoside-diphosphate reductase subunit M2 B
Sequence:
MRCGGGARACRRACRCWLSGYAGPADGTQQPDAPEHAVAREALVDLCRRRHFFSGTPQQLSTAALLSGCHARFGPLGVELRKNLASQWWSSMVVFREQVFAVDSLHQEPGSSQPRDSAFRLVSPESIREILQDREPSKEQLVAFLENLLKTSGKLRATLLHGALEHYVNCLDLVNRKLPFGLAQIGVCFHPVSNSNQTPSSVTRVGEKTEASLVWFTPTRTSSQWLDFWLRHRLLWWRKFAMSPSNFSSADCQDELGRKGSKLYYSFPWGKEPIETLWNLGDQELLHTYPGNVSTIQGRDGRKNVVPCVLSVSGDVDLGTLAYLYDSFQLAENSFARKKSLQRKVLKLHPCLAPIKVALDVGKGPTVELRQVCQGLLNELLENGISVWPGYSETVHSSLEQLHSKYDEMSVLFSVLVTETTLENGLIQLRSRDTTMKEMMHISKLRDFLVKYLASASNV
Protein: Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (M phase MAP kinase) (Myelin basic protein kinase) (MBP kinase) (Myelin xP42 protein kinase) (P26696)
Organism: Xenopus laevis (African clawed frog)
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the MAPK/ERK cascade. Depending on the cellular context, this cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Many of the substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. Phosphorylates microtubule-associated protein 2 (MAP2), myelin basic protein (MBP) and Elk-1. Phosphorylates dual specificity protein phosphatase 1 (DUSP1) during meiosis, increasing its stability. Activated by M phase promoting factor (MPF). Plays a role in the spindle assembly checkpoint.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:9128253}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9128253}. Note=Associated with the spindle during prometaphase and metaphase in cultured XTC cells.
Interaction partners:
Sequence:
MAAAGAASNPGGGPEMVRGQAFDVGPRYINLAYIGEGAYGMVCSAHDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFKHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADPKALDLLDKMLTFNPHKRIEVEAALAHPYLEQYYDPSDEPVAEAPFKFEMELDDLPKETLKELIFEETARFQPGY
Protein: Peroxidasin homolog pxn-1 (EC 1.11.2.-) (Q1ENI8)
Organism: Caenorhabditis elegans
Function: Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV NC1 hexamer (By similarity). Plays a role in the attachment of tissues and in axonal guidance during early developmental stages. May functionally antagonize the peroxidasin pxn-2 to maintain neuronal development.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:25475546}. Note=Localizes to the extracellular space in between body wall muscle cells. {ECO:0000269|PubMed:25475546}.
Interaction partners:
- Actin
- Peroxidasin homolog pxn-2
- Glyceraldehyde-3-phosphate dehydrogenase 1
- Glutathione peroxidase 2
- Glyceraldehyde-3-phosphate dehydrogenase 4
- Glyceraldehyde-3-phosphate dehydrogenase 3
- Glyceraldehyde-3-phosphate dehydrogenase 2
- Latrophilin-like protein 1
- Glutathione peroxidase
- Glutathione peroxidase
Sequence:
MNLYLLLLVIATSSWQFVAGLECPVECTCDKKGLVVDCSSSGLTRIPKNISRNVRSLVIRNNRIHKLKRSDLEGFNQLETLVLTHNKIKIIEENVLDHLPELKRLSLAHNELVYIPPLCSDSRPLASLNLKRNHIQFIDEQVLRYFPDLTQLDFSHNRIQSLRTKLFDNLPALSHAHLHSNPWHCDCRASKVKALLQKVKWEKKVYCTNPVELRHQALDEVDDSALTCARPAEESWTGEEIKLTCAKNSSSKLVVWMYENVEVDSSSLDGYEIHDTVITVPRKTNVNFMTCTYDFDHIPHHRRLRQSQHQGNGSPQFTYKPRDNSFREGSEVKVNCEVMGNPKPTINWYHNGKRFISSRKRQLGLSNNVLRIYPFLEEDSGRYTCEAVNSVGKVRHAFSLDLISSVPPNIYEGPQSVSQNLGGSVVFVCKANGNPVPDYTWSFDGSTIGHIKGRFMVSDDGTELRISNIEKKDEGYYSCMAGNPVGAMSADAKLTVIGGETRKAAAPQIDEELLRAIAQKARQNVENAVEKTRKQLTQDKVTNTNDLKRLFRFSTPKQAVELSKAREIYEESVRLVREHVEKGLILNVDELHPKNVSYESVLHVTHVQALMGLSGCHTGQYKNPCTDTCFHHRYRSFDGQCNNKNKPMTGVSLMPLRRLLKPVYENGFNTPVGWEKGRLYNGYPLPNVREVSRQLVATENITPHSKLSSMVMQWGQFVDHDLTHTVTALSRHSYATGAFCNRTCENLDPCFNIPLSPNDPRVKSGSAKYPCIEFERSAAVCGSGETSLVFNRVTYREQMNALTSFLDASNVYGSNEVQAQELRDTYNNNGMLRFDITSEAGKEYLPFEKDSNMDCRRNFSEENPIRCFLAGDLRANEQLALAATHTIFIREHNRIAKKLKSMNGNWDGEIIYHETRKIVGAMMQHITYKHWMPIIFGGQAQMNKFVGTYQGYDPDVDASVTNAFATAAFRFGHTIINPSLFRLGNDFMPIKEGHIALHKAFFTPELVLTQGGVDPLLRGLFASPLKHPMPTQLLNMELIEKLFMKGHEVSLDLAVMNIQRSRDHGLPSYTEYRKFCNLPVPVQWEDMKGYIKDDMIIQKLRGLYGVPQNIDLWVGGIVEEKLENGLFGPTFACIIGEQFRKIRDGDRFWYEKDGVFTPEQLREIKKITLARLFCDNGDNIDRIQKDVFMYPGMDKENYGTCQETEMMNLRAWSKCCDNVCPTMLDRILRSRHRGSRLHGCNQNGIWRPEGAKWIPQNEICTECVCQGSRVWCSTKEDCSDNRSPF
Protein: LD37002p (Syntaxin 18) (Q9VC58)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
Interaction partners:
- Centromere/kinetochore protein zw10
- Secretory 22, isoform B
- Vesicle transport protein USE1
- RINT1-like protein
- Syntaxin-5
- Syntaxin 8
- LD34211p
- Protein sly1 homolog
- BET1 homolog
- Syntaxin 17, isoform B
Sequence:
MDITQSFKASVMTVRLQRKAELAGKAKPATVPTKTGPIGPKDDFAKQAKEVCNKITSLRNVLIENRTAYMRIGQHLKSAAHMTDAQRDLIDRESEKFVTFYTQHLAKMRSDWKSAKRKPQERQHIDAVLDLLVSYLHSVEQIYLDQKKYRVQHELETYRLLKLAADKKKIPVRPAGSNSGKLGRRQVSNDDSEATKSSSQANGNHDESADNDWNNDAWGDWDEDEEGDEVDDHDGEKGKEANQANQHKPRTRKRSKANRSDLNNSSSKMALDEELQQQQEADDDDPLSAEDVQLFEAENVHIYNFLQGVSEEVEQIEKNVVDIAQLQDIFTEKVAMQQHNIDRIVSAVVGTTENVKDANEQIRQATQRNAGLRVWSLFFLLVMSFSLLFLDWYYD
Protein: TEA domain family member 4 isoform 1 variant (Transcriptional enhancer factor TEF-3) (Q53GI4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
LEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE