wanglab/gogpt-training-data huggingface dataset:
Protein: Protein FAM43A (Q8N2R8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLPWKKHKFELLAEAPPRQASKPKGYAVSLHYSALSSLARACPEGALSRVGSMFRSKRKKLHITSEDPTYTVLYLGNATTIQARGDGCTDLAVGKIWSKSEAGRQGTKMKLTVSAQGIRMVHAEERALRRPGHLYLLHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEKAQAMALLLYQTSANALAEFKRLKRRDDARHQQQELVGAHTIPLVPLRKLLLHGPCCYKPPVERSRSAPKLGSITEDLLGEQLEQELQEEEEEEQPEGCPEEEENRAAEGDPAEEEAEAQRALVVAMHFECGDLLDTLENGRGEALGGGGGSLGPGAGPPPLLLGSASDMKAELSQLISDLGELSFGNDVRTLQADLRVTRLLSGDSTGSESSIEGGGPDATSATAGDSSRQADGASADEPHSG
Protein: Mitochondrial substrate carrier family protein (Putative mitochondrial carrier protein) (Q949U9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Protein NPGR1
- Mitochondrial uncoupling protein 6
- Mitochondrial outer membrane protein porin 4
- K
- Equilibrative nucleotide transporter 3
- Mitochondrial uncoupling protein 4
- Mechanosensitive ion channel protein 10
- Mitochondrial uncoupling protein 5
- NADH dehydrogenase 1 alpha subcomplex subunit 1
Sequence:
MDTPPTSRIASFGQTEINWDKLDKRRFYINGAGLFTGVTVALYPVSVVKTRLQVASKEIAERSAFSVVKGILKNDGVPGLYRGFGTVITGAVPARIIFLTALETTKISAFKLVAPLELSEPTQAAIANGIAGMTASLFSQAVFVPIDVVSQKLMVQGYSGHATYTGGIDVATKIIKSYGVRGLYRGFGLSVMTYSPSSAAWWASYGSSQRVIWRFLGYGGDSDATAAPSKSKIVMVQAAGGIIAGATASSITTPLDTIKTRLQVMGHQENRPSAKQVVKKLLAEDGWKGFYRGLGPRFFSMSAWGTSMILTYEYLKRLCAIED
Protein: Closca (A8DQW8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Female sterile
Sequence:
MYQICCNLLIFAAVIARVISFEVNFRESYPTHFLNSDQESMLHKRATAVPQFFDQASFSFDGLERVASVPVSFPLDICILQLPTVKYATALHKNAAGVRHFAVYTWRPAEQDYQLLVELETPKAVALDCLAFAGRGYVAVSYNLTEPVSQAREGSPIYEISPETGIRTVQYFSGTHLRGMYLRISSQELTLLHAFESNAQCPYFKWMGKSFQRLGAIHCSKARRMEAFGIDYTDYVAVANYADAEGRTATHSEIFRWDAKSQRFQLFQRLRSNGAVDVKYFSLPVNEVSRRHFLILGNTIGGTGAEVGDADTVIYVFEKGQFVPYQRLSFYALERVLPVQHSISEKFLLLVACNKQDVKIYNLNDWRFEESKVQFTEGALSRGVARMRSYEEGDQSYLVIANENMAANETNIFQPLYKQDEHANILRQQIIDWAREQRKRLEQMNLDHLLIRLKDKLKHREEKLKVSIIKQVNAKSFEDKHMKLTPNYWKALKLTKQALDKIEQKTTLAGSRHPNKRSVDQPNEEPNFDEVTVDTLVVHGAVKADHINGVDTRNPVYDSVTANKVYVSAKYTEPAGKERKLLLDELIVKDLQLDGRLNGLKWADLFDLTLKRSNKDVQFIKAAADFDHLESDAAQVNNNEVNDRPLGLLIPVDGGDFIVQQDVQFSQPIQVNRLLINQRLNHIHVDRQRFDVLTKQANHTQVIEGSMRFENVRVMEPITIAGQIMGAELRAMSPAKVTHKSLQLNGDFVVDGDVTIGRLLQMKDFVDESTQKSAAEALTRGLRLDQPLEDVNLNFVEPLIANNTELSFINTQDLQNLVKLNVGEVQLVQASKIFPQNVEIRDGFGEIKWLNGIDTERLPEIMLTKSGNQTISSSIQLQGVELNHVNSSQILLNDLGVEDYLQTGQDQKSNGTLYIDNMDVREMSVNDLHLNGHLFGQTMSSIYEHGSKSLDSWHLPPDFNGTIHAQNLWLSGHINKVKVVQLEQQLQQLAGNVKYVGDFTFEHDVNISSLSFENSLNGIEANKFGSCWLETDRDQTFTAPQKLASLDSQQGLWLRGQLNNHTLQDLENRSYRLNSPEHLQSVRFANPIVLQSELQLDRLNGLRVPEDVIYHNGGAYISAPVSVDGDLEALKLSNITNLNGYPLEALEIYLSGQNVRTFVAENVKFGGEPSYQLLNGHNLGNLLDQVWLDNEQIELREIKLESGQFEGLLEFQGPINGHQVDHITHNYFSRTRSNLLKTPLSFQHDVTFAQPPVAKYVKLRRGSSGVLMEGTSSNFSLDFDDFVTHSLKTAGSHAISGYWKLPEAFISGNLNDIYINNLNLANDVVRMPLQNDSINLPLIVEALKTVQGGTINRLHTTPESQVADVPVAKWIHGAAYLYGNHSISGITHLNNVNLYNDLTVNGSVNGVPWQADKLILMDNEQDIPGSLLVANSLPEQKRVMSNNVKNLWVDFVNDLPVNELLVSKAENRPNLHVESQLIFTQPLTVGHYEAGNGNGLLDKYYKKKRGVESNDIHDWQQLQENVAAIKNRLAKPPKVLEGFAVLQKLPHKASHMKIISVDNEDVLAIWEQMPSEVGTTYTWQPDIHLFGRSSSTALTQLNKTNLNPINEEAQNPQKLQFRSYGFQCRALQEENQIVIRCLDEQNNSREAILPRRAVKQLLPVADSDDMTILLRTPRAVELWKWSNGNYSLSSRLIDGQVEQMALSQGGAGIESGYVALMASSPAAEIRIYSFGSPDTSSFQLDQVLELEDSQQSRVMRFMHLPESDDLLLCVSNVLPQQPLRIYQHRGAAGFQQILGDSALPKAHALEVLYLPSHKLRLLSMATEESVYLLQPQFTTL
Protein: MYB-like transcription factor 4 (PhMYB4) (MYB-like protein MYB5d8) (Protein EMISSION OF BENZENOIDS III) (PhEOBIII) (F1B281)
Organism: Petunia hybrida (Petunia)
Function: Negative regulators of floral scent production by repressing the expression of C4H1 and C4H2, components of the floral volatile benzenoid/phenylpropanoid (FVBP) biosynthetic pathway.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
Sequence:
MGRSPCCEKAHTNKGAWTKEEDERLIAYIKAHGEGCWRSLPKAAGLLRCGKSCRLRWINYLRPDLKRGNFTEDEDELIIKLHSLLGNKWSLIAGRLPGRTDNEIKNYWNTHIRRKLLSRGIDPTTHRIMNEPSTQKVTTISFAAGNEDIKDQKISIKAEFEQIKDDEIISKPIKEQCPDLNLELKISPPYQQHSDRALQQSTTGSGGASTICFTCSLGLKNNKGCSCSRNRSMNVAGYDFLGLKTNGLDYRTLETRTK
Protein: Magnetosome protein MamA (Q2W8Q0)
Organism: Paramagnetospirillum magneticum (strain ATCC 700264 / AMB-1) (Magnetospirillum magneticum)
Function: Probably forms a large homooligomer on which other magnetosome subunits assemble (Probable). Required for formation of functional magnetosomes from pre-existing vesicles, it has a dynamic location in the cell.
Subcellular location: Magnetosome membrane {ECO:0000269|PubMed:15004275, ECO:0000269|PubMed:16303747, ECO:0000269|PubMed:20212111, ECO:0000269|PubMed:20439702, ECO:0000269|PubMed:21784982, ECO:0000269|PubMed:28955887}; Peripheral membrane protein {ECO:0000269|PubMed:20439702, ECO:0000269|PubMed:28955887}. Note=Reversibly binds to magnetosomes (PubMed:20439702). Forms oligomers that cover the surface of the magnetosome (PubMed:20439702). Its location is dynamic; in log phase cells tagged protein extends from one pole to the other, which is longer than the magnetosome chain and is occasionally associated with the inner membrane. In stationary phase it forms 3-4 spots in the cell (PubMed:15004275, PubMed:21784982). {ECO:0000269|PubMed:15004275, ECO:0000269|PubMed:20439702, ECO:0000269|PubMed:21784982}.
Interaction partners:
- Probable membrane transporter protein MamO
- Magnetosome protein MamB
- Magnetosome protein MamQ 1
- Magnetosome protein MamR
- TPR repeat protein
- Multi-heme protein MamP
- Predicted O-linked N-acetylglucosamine transferase
- Magnetosome protein MamS
- Magnetosome protein MamM
Sequence:
MSSKPSDILDEVTLYAHYGLSVAKKLGMNMVDAFRAAFSVNDDIRQVYYRDKGISHAKAGRYSQAVMLLEQVYDADAFDVDVALHLGIAYVKTGAVDRGTELLERSLADAPDNVKVATVLGLTYVQVQKYDLAVPLLIKVAEANPINFNVRFRLGVALDNLGRFDEAIDSFKIALGLRPNEGKVHRAIAFSYEQMGRHEEALPHFKKANELDEGASV
Protein: Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) (P40582)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein.
Interaction partners:
- Peroxiredoxin PRX1, mitochondrial
- Glutathione reductase
- Glutathione hydrolase proenzyme
- Transcriptional regulator URE2
- Glutathione synthetase GSH2
- Glutathione-specific gamma-glutamylcyclotransferase
- Glutathione S-transferase 2
- Glutathione S-transferase omega-like 2
- Glutathione S-transferase omega-like 3
- Glutathione S-transferase omega-like 1
Sequence:
MSLPIIKVHWLDHSRAFRLLWLLDHLNLEYEIVPYKRDANFRAPPELKKIHPLGRSPLLEVQDRETGKKKILAESGFIFQYVLQHFDHSHVLMSEDADIADQINYYLFYVEGSLQPPLMIEFILSKVKDSGMPFPISYLARKVADKISQAYSSGEVKNQFDFVEGEISKNNGYLVDGKLSGADILMSFPLQMAFERKFAAPEDYPAISKWLKTITSEESYAASKEKARALGSNF
Protein: glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Q9VTH7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Serpin 38F, isoform A
- Accessory gland protein Acp62F
- Accessory gland protein Acp29AB
- Serpin 28F
- Male-specific opa-containing protein
- Aquarius
- Accessory gland protein Acp53Ea
- GH21475p
- Accessory gland-specific peptide 26Aa
- Accessory gland protein Acp76A
Sequence:
MPCWRSFIALICLAIIVVVITICQSFHTNFLTVGRNGTLRYEPTELNLGQMRMIAGLSDPENLRKNVQRIAIKRAVSTPGHSEVRNYIVDYLKKLNWNVELDIFTQKVPIMSNVTFHNIVARQNPQTQRYLMFGCHYDSKYFKDFDFMAATDSAVPCALMLNMATILKHQFHRSQVSLMLVFFDGEEAFGEWSQEDSPYGSRHLAELWEKHGFLDKIDLFVLPDLIGAKDVVFKKNILDTSGWFHRLVQLELKLFQAGIVRSERPLFKFEPGIDVDDDHLPFTRRNVPVIHLISNKYPAVWHQAEDVEMNVDYNTTEQVGLVLRMFVMEYLNSAPSISNTLK
Protein: Anion transporter ABTS-2 (Bicarbonate transporter-like transmembrane domain-containing protein) (G5EGB9)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MPELLCRTERVEHARNFKTEVRGLMDVDHLIERACIHRNMNHSHIHTILLSLFSDLSSRFPQEKFDLALFKNAVFSVSDRDSRAPRLHHKLQSYSGTDFFDVNQTWIVTYAQLDGLKQSHMALATLEDATNLGLEMEEARTVVLILSPSYEKHTKSAAEIARTFATLLMNDTLRQSVNDAADDDQLRDLLTEYAKGLSQQLTIQVNGKPIADDDDEYESKNSSFCPYYPFRGLVKDFKRRMANYKSDYLDGIKDRRSVSKVISTAVFLIFTILPTSIAYGMLNENNTNGAINVQKVVLGQWIGSLLFGIFGGQQLLILSTTAPLSIYIAVIYQVAQTNDWDFFQMYASVGIYAMGLLILASVFQLASLMKFTTRSTEEIFSVFIALALIIKAIMAIVHVYTHGYLGCINNVAGDLCDPAEPLLFIFLLFGTTWLSMTIISFRSSPYLSRWKRDLVSDYALPIAVLVFSFISFFGFSDVKKEQFQIFSRETDAFFVPFFNLPAEAQLPAVGLAIPLSILFFMDQLLVTNTVDNKDNKLKKGSAHHWDLLVVGVLNIGLSIFGLPWMHGALPSAYLHLKALSDVEDRLHNGYIQTVIVHVRETRLATLIAHIIMIPIYFFLVPHITVFIPTSIFNGVFLFMAFSSLTGNEFWERILLIFTEQRAYPPTHYIRRVPQRVVHQFTIIEFIQLVILVAIGFAQYHYVEMVFPIVIAAFIPFRHFFLPLFIRKQYLEAIDGQH
Protein: Similar to part of disease resistance protein (Toll-Interleukin-Resistance (TIR) domain family protein) (Q9SSN4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Heat shock protein 70
- At3g17830
- Cytochrome P450 705A12
- AT4g14060/dl3070w
- Major latex protein-like
Sequence:
MSSPTATKYDVFLSFRGLDTRRNFISFLYKELVRRKIRTFKDDKELENGRRISPELKRAIEESKFAVVVVSVNYAASPWCLDELVKIMDFENKGSITVMPIFYGVDPCHLRRQIGDVAEQFKKHEAREEDHEKVASWRRALTSLASISGECSLKWEDEANLVDEIADKISKNLMTVTTISNGRDLVGIDTHMKALNKKLDLNSNKSLRVVGIWARGYNGRSALAKYVYQDICHWLKVGWLKVYQDIKTASKLYVLTRWLKVAHLLHRSHHSFKTE
Protein: Putative Rho guanine nucleotide exchange factor FGD-1 (G5ED03)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSSLVQLPSQPSSAFQLDFDAVRNFQNVPPVDLEGGTLIDATEEEEIDPVDGCTVRVFTYRILSADEMEELTKTVRQKIKFDCTQTMRSLKMIGSEANVVEKSQRISGDIKGMKPIEFSNNSKQICLDQHSLQLDPNDEQDQQISRVLNQVPNTFMSLLSREKDMFVKLYPELFEKMRTESSLIPSTTTEIITNPDGSTTTRVKSSKSYSSHFSRQETYVNGVKKMSKSKFRAFVEYKGPDGGFQVKLSDGDEFELSEDEQEDDDTSLSQSCYSEIDSESDITGPSPKTDLDKRYQKAWYAAKELVDSEQRYVDKLKLLGDTFRNRLIKEELITNDKITRLLANVSSLYQFHNTHFLPQLLESIRDWHTTKRIANVVRKQAPFLKMYSEYTNNYDRATKLFEELKKKKKFADVVKEIEKQAECEGLPLGHHLICPVQRVMRYQLLLQEYKKHLQPSDVDFDDTTVALELVLQAAAHANEMMKKLDRFGKVIEVQEQLGNSISLVSPGRELLKSGSVQKISSTTEKTEERFIFLFNDLVILASERKMIGVSKYKLRAVFSASHMQVCEGDNLEREHSFYLRGSDGTGPKRCVELFTPTQKEKNDWVDSIFSIIDEAKAHSLTFTSSSRSSISENNNNSIESKHCADCDIEFGFLSRGSKCVKCSRRLCKKCFGRRRNESKKHRICDTCTKNMDLDGIPRSFSTQSNMRRNLLQLPAKGSGVLHSSQIRHLRQKPELQQIFHNCYYLFRGSLGKLLDRFMVVRDDFCMYTYSSEEDICALAMLPLPGCEVKMCGEKFTFSVRVGARRMYTMTAEDEQTQMKWLAILDLAANAHLKNQRNSGSEQSE
Protein: Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) (Q384I4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|HAMAP-Rule:MF_03023}.
Interaction partners:
- ATP-dependent protease subunit HslV
- Uncharacterized protein
- Katanin, putative
Sequence:
MSTSNDVLVNSKNSVSVARRYALYSNYELALAIYNSLDKDFDAYLDSCKDKQEHKKWKQVKERIAEEGALVRAIQDELRAFVNPSEAARIDRQQWRKQQEEFKPICGGEENGQSDRGAGKAARLTTLHITKSVPPNLSRLASQSLFESNPSTRNQLLYGDKDRFGPPEGPVIRKSKAVNPQPAQRFASPVVRRRPVITSSNTASLTNGSQTVPPKAKIAPRRVERPKENATRGQMPRSSVPRFVPRSGEEELVALIEADMHVGSLSVGWEDVAGLQDAKGLLEEAVVYPVLMPEYYQGIRRPWKGVLLYGPPGTGKTMLAKAVAAECNTTFFNISPATLTSKWRGDSEKLIRVLFEMARHYAPSTIFVDEIDAVCSQRGESSEHEASRRAKGTLLAQMDGLSVDPGKTVMVLGATNHPWSIDEAMRRRLEKRIYIPLPDYKDRLELFRINTKTLKLSPDVDFDKLSKMLEGRYYSCADLTNLVRDAAMMTMRRFMEEMDKTEVKRRAAEIGKLVAEQPITMDDFLNAVRNVPSSINVEQIKKFEKWKKEFEVNV
Protein: No extended memory, isoform M (EC 1.-.-.-, EC 1.16.1.7) (E2QCC2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MFYRDGFAWSESPKQQFNLHPILMIAGFVTLSGFSILIYRLCRCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVMLCCENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEKERETVNEAGVSENKLVEHYITSAIGVTLIFIGIIVTFAVRRSNAPASAKVYVTERI
Protein: E3 ubiquitin-protein ligase XBAT32 (EC 2.3.2.27) (Ankyrin repeat domain and RING finger-containing protein XBAT32) (Protein XB3 homolog 2) (RING-type E3 ubiquitin transferase XBAT32) (Q6NLQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of ACC synthases (ACS). Negatively regulates ethylene biosynthesis probably via ubiquitin-dependent degradation of ACS4 and ACS7 enzymes. Regulates lateral root formation and development by controlling ethylene production which inhibits lateral root formation at high concentration.
Interaction partners:
- Putative E3 ubiquitin-protein ligase XBAT35
- Ankyrin repeat domain-containing protein EMB506, chloroplastic
- 1-aminocyclopropane-1-carboxylate synthase 7
- Ankyrin repeat-containing protein BDA1
- Ethylene-overproduction protein 1
- ETO1-like protein 1
- E3 ubiquitin protein ligase RIE1
- ETO1-like protein 2
- 1-aminocyclopropane-1-carboxylate synthase 4
- BTB/POZ domain-containing protein At3g22104
Sequence:
MRFLSLVGNSFGCSASGERLVSAARDGDLQEAKALLDYNPRLARYSTFGVRNSPLHYSAAQGHHEIVSLLVESGVDINLRNYRGQTALMQACQHGHWEVVLILILFGANIHRSDYLNGGTALHLAALNGHPRCIRILLSEYIPSVPNCWSLLKNKKTSVAGFDSSVLHEVINRAADGGITPLHVAALNGHIETVQLLLDLGASVTQVTVEDGTTIDLIGAGSTALHYASCGGNTQCCQLLISKGACLAAVNSNGWTPMMVARSWHRNWLEEILNPTTEQPQLHLPNVPSPFLCLPLMSIVNIAQECGWRENDCLTPCRDPCAVCLERKCTVAADGCAHEFCTNCALYLSTTSITSSKTSNVTPGSVPCPLCRNGIVSFTKLPHTTATTRTSTSSRTSISLSFCTCSSDVLDTALLTNPHYSCKPVVSRTGSRTPQSARSSAFRSLSCRRFPPSLCLGGSDVDEPRSRLIGGSYSRSGVGFRRSTSQVEGKRSWFSALNHCVTTGGSAC
Protein: Zinc finger protein 430 (Q9H8G1)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQGKEPWNMKRHAMVDQPPVTYSHFAQDLWPEQGIKDSFQEVILRRYGKCGHEDLQLRTGCKSVDECNLHKECYDELNQCLTTTQSEIFQYDKYVNVFYKFSNPNIQKIRHTGKKPFKCKKCDKSFCMLLHLTQHKRIHIRENSYQCEECGKVFNWFSTLTRHRRIHTGEKPYKCEQCGKAFKQSSTLTTHKIIHTGEKPYRCEECGKTFNRSSHLTTHKRIHTGEKPYRCEECGRAFNRSSHLTTHKIIHTGEKPYKCEECGKAFNQSSTLTTHKIIHAGEKPYKCEECGKAFYRFSYLTKHKIIHTGEKFYKCEECGKGFNWSSTLTKHKRIHTGEKPYKCEQCGKAFNESSNLTAHKIIHTGEKPYKCEECGKAFNRSPKLTAHKVIHSGEKPYKCEECGKAFNQFSNLTKHKITHIGDTSYKYLECDKAFSQSSTLTKHKVIHTGEKPYNCEEYGKAFNQSSNLIEQSNSYWRETLQM
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q7YU60)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MLSALRLIFLGALLGASVCASPIEFVMDTSLNGSRSDPATATHPGKWPPTTKAPALRAPAGTAGHAYQSPSSSLAADNRSHDNNNASAVSMLLPQDGDASGAVAPAVTPQLPIYIAQPSAKKPENKIKCHCDTCKESNNICETDGFCFTSVEKNSDGSIIFSYRCITDQLPPEDPTSCKLNSEAGSSQCCAEDFCNTRENYSGVLPDYVPHRLTSWEFVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFAKEDSAYDPILNGNTTIHDIIEMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDKVKN
Protein: Bacterial proteasome activator (P9WKX3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.
Interaction partners:
- Proteasome-associated ATPase
- Proteasome subunit alpha
- Probable O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE
- Probable O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD
- Proteasome subunit beta
- Galactofuranosyltransferase GlfT1
- Probable conserved transmembrane protein alanine and leucine rich
- Pup deamidase/depupylase
- Pup--protein ligase
Sequence:
MVIGLSTGSDDDDVEVIGGVDPRLIAVQENDSDESSLTDLVEQPAKVMRIGTMIKQLLEEVRAAPLDEASRNRLRDIHATSIRELEDGLAPELREELDRLTLPFNEDAVPSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLQQMRQGALPPGVGKSGQHGHGTGQYL
Protein: Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) (P59999)
Organism: Mus musculus (Mouse)
Function: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P59998}. Cell projection {ECO:0000250|UniProtKB:P59998}. Nucleus {ECO:0000250|UniProtKB:P59998}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 1A
- Actin nucleation-promoting factor WASL
- Actin nucleation-promoting factor WAS
Sequence:
MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF
Protein: Protein bicaudal C homolog 1 (Bic-C) (Q99MQ1)
Organism: Mus musculus (Mouse)
Function: Putative RNA-binding protein. May be involved in regulating gene expression during embryonic development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19324013}.
Interaction partners:
Sequence:
MASQSEPGYLAAAQSDPGSNSERSTDSPVAGSEDDLVAAAPLLHSPEWSEERFRVDRKKLEAMLQAAAEGKGRSGEDFFQKIMEETNTQIAWPSKLKIGAKSKKDPHIKVSGKKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEDTGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARARIRELLPLVLMFELPIAGILQPVPDPNTPSIQHISQTYSVSVSFKQRSRMYGATVTVRGSQNNTNAVKEGTAMLLEHLAGSLASAIPVSTQLDIAAQHHLFMMGRNGSNVKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEDIEVDPQVIAQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVSIATSLSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSATPNSLLNALNTSVSPLQSSSSGTPSPTLWAPPIANTASATGFSTIPHLMLPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQTEGKNISASINGHVQPANMKYGPLSTSSLGEKVLSSNHGDPSMQTAGPEQASPKSNSVEGCNDAFVEVGMPRSPSHSGNAGDLKQMLGASKVSCAKRQTVELLQGTKNSHLHGTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQKSERARLASQPTYVHMQAFDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTAYEGSSLSLSRSSSREHLASGSESDNWRDRNGIGPMGHSEFSAPIGSPKRKQNKSREHYLSSSNYMDCISSLTGSNGCNLNSCFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELSKNRRKLFEPPNASCTSFLEGGASGRLPRQYHSDIASVSGRW
Protein: DnaJ homolog subfamily C member 17 (Q91WT4)
Organism: Mus musculus (Mouse)
Function: May negatively affect PAX8-induced thyroglobulin/TG transcription.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:D3ZSC8}. Nucleus {ECO:0000250|UniProtKB:D3ZSC8}. Note=Predominantly nuclear. {ECO:0000250|UniProtKB:D3ZSC8}.
Interaction partners:
- TCF3 fusion partner homolog
- WD repeat-containing protein 53
Sequence:
MAVTKELLQMDLYALLGIEEKAADKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALEVLTDAAARAAYDKVRKAKKQAAERTQRLDENRKKVKLDLEARERQAQAHGSEEEEESRSATTLEQEIARLREEGSRQLEEQQRLIQEQIRQDREQRLRGRTENTEGKGTPKLKLKWKCKKEDESQGGYSRDVLLRLLQKYGEVLNLVLSRKKAGNAIVEFATVRAAELAVRNEVGLADNPLKVSWLEGQPQSTVDPGPPGLSKGSVLSERDFESLVMMRMRQAAERQQLIAQMQQEDEGRPT
Protein: Male-specific protein scotti (Q9VFK3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Post-meiotically transcribed gene that has a role in late spermiogenesis; required for actin cone progression during spermatid individualization.
Interaction partners:
- AT19737p
- Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
- Salto, isoform A
- GH20441p
- GH07855p
- GH03227p
- AT18965p
- Uncharacterized protein
- Uncharacterized protein, isoform E
- GH26058p
Sequence:
MDVLHGHDLYDEQLIDRVGDAVNEDAGDDLDTLEDGQQQQRLGVNRQMDILLDAPQEPPLGVFPAQGGPNGPPRRRKKRSFYTMTKPTPPCQSQEPEMCLLMASVTRAMRHVREDQRGEYFANYLVENMTSQNYPNGMGLPQHWGQF
Protein: RE30195p (Q7YU40)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSAM
Protein: Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va) (P83012)
Organism: Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00426}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00426}; Matrix side {ECO:0000250|UniProtKB:P00426}.
Interaction partners:
Sequence:
SHGKQETDEEFDANL
Protein: Enolase 2 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase 2) (2-phosphoglycerate dehydratase 2) (Q6FQY4)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Phosphoglycerate mutase
- Pyruvate kinase 2
- Pyruvate kinase 1
- Glucose-6-phosphate isomerase
- Fructose-bisphosphate aldolase
- Phosphoglycerate mutase
- Phosphoglycerate kinase
- Transketolase
- Phosphoenolpyruvate carboxykinase
- Triosephosphate isomerase
Sequence:
MAVSKVYARSVYDSRGNPTVEVELTTEKGVFRSIVPSGASTGIHEALEMRDGDKSKWLGKGVENAVKNVNDVIAPAFVKANVDIKDQKAVDDLLLSLDGTANKSKLGANAILGVSMAAARAAAAEKNVPLYQHLADLSDSKTSPFVLPVPFLNVLNGGSHAGGALALQEFMIAPTGAKSFREAMRIGSEVYHNLKSLTKKRYGSSAGNVGDEGGVAPDIQTAEEALDLIVDAIKAAGHEGKVKIGLDCASSEFFKDGKYDLDFKNPNSDASKWLSGPQLADLYHSLVKKYPIVSIEDPFAEDDWEAWSHFFKTAGVQIVADDLTVTNPKRIATAIEKKAADALLLKVNQIGSLSESIKAAQDSFAAGWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAPARSERLAKLNQLLRIEEELGDKAVYAGDNFHHGFKL