wanglab/gogpt-training-data huggingface dataset:
Protein: Sorting nexin 2A (Q8L5Z7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in vesicular protein sorting (By similarity). Acts at the crossroads between the secretory and endocytic pathways. Is involved in the endosome to vacuole protein transport and, as component of the membrane-associated retromer complex, is also involved in endosome-to-Golgi retrograde transport (By similarity). Also involved in the efficient sorting of seed storage protein globulin 12S.
Subcellular location: Cytoplasm. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Prevacuolar compartment membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side.
Interaction partners:
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein sorting-associated protein 35C
- Vacuolar protein sorting-associated protein 26A
- Vacuolar protein sorting-associated protein 35A
- Vacuolar protein sorting-associated protein 35B
- Sorting nexin 1
- Vacuolar protein sorting-associated protein 26B
- Sorting nexin 2B
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- Biogenesis of lysosome-related organelles complex 1 subunit 1
Sequence:
MMGSENADGFEETNLNAQRDDMENLDLGVDGGDHPLKISDVNGDTSNSGYRSAMSTLSNVRDPLSPPPTVMIPADSDPLLAPSSYEDFRSSFSSKPISSDNSYIEPPSYADVIFSPFDENSDSEINGTEDNSLHSQFSDSLSRSPSSSSSDYIKITVSNPQKEQEISNSIVGGNTYITYQITTRTNLPDFGGPSEFSVRRRFRDVVTLADRLAETYRGFCIPPRPDKSVVESQVMQKQEFVEQRRVALEKYLRRLSAHPVIRNSDELKVFLQVQGKLPLPMSTDVASRMLDGAVKLPKQLFGEGGASAVPVTEVGQPARGGRDLLRLFKELRQSVSNDWGGSKPPVVEEDKEFLEKKEKMHDLEQQIINASQQAESLVKAQQDMGETMGELGLAFIKLTKFENEEAVCNPQRTRANDMKNLATAAVKASRFYRELNSQTVKHLDTLHEYLGMMMAVQGAFADRSSALLTVQTLLSELPSLQTRVEKLEAASSKVFGGDKSRIRKIEELKETIKVTEDAKNVAIKGYERIKENNRSEVERLDRERRADFMNMMKGFVVNQVGYAEKMGNVWAKVAEETSQYDREKQSS
Protein: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase) (PGP synthase) (Q9HDW1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Putative phosphatidate cytidylyltransferase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Probable phosphatidylglycerophosphatase, mitochondrial
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10
- Phosphatidylethanolamine N-methyltransferase
Sequence:
MDEGIEKNIFVNLESQIDGVCPKFYVNVDDIDIIHEPPEFYQRLKKLIKKAQKRIFLSTLYIGKEERELINCLSNALSNNPSLHVHILADQLRCTRESPGCCSASLLMQLKKKFPDRCEIKLYHTPNLRGLRKQLVPHRFNEGWGLQHMKIYGADDNLIISGANLSRDYFTNRKDRYYLFSDKGLADFFFKTHFLFSQLSFECIPHLSDSSIQLSSTSPVIPFTLKWNNSCPNPLTNPQEFRVAASAKIQQLLQGNREKFLSRNPSKPLSSVYGSELINQAGDDNNKPFHKYEESAIVYPLFQCVPILTSDVHSTEEKVLSIIGTLLSRKEVNWTLTAGYFNVYPALRKQLLKSEGIGEVIVASQQANGFYRSPGPSKLIPPAYQYIAEQFLKDSRKKKRNIDVLQWQNKGNTYHAKGFWLSTQHHKHPFLTTIGSSNYTSRSQQLDLESTLVVMTQNEKLKRKFSTEIELIKQHTKPMNTCQLEKVPMYVKALTSLMKKKL
Protein: Medium-wave-sensitive opsin 1 (Green cone photoreceptor pigment) (Green-sensitive opsin) (M opsin) (Medium wavelength-sensitive cone opsin) (O35599)
Organism: Mus musculus (Mouse)
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P04001}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Arrestin-C
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Cone-rod homeobox protein
- Short-wave-sensitive opsin 1
- Recoverin
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Sequence:
MAQRLTGEQTLDHYEDSTHASIFTYTNSNSTKGPFEGPNYHIAPRWVYHLTSTWMILVVVASVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLATVGIVFSWVWAAIWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYAFHPLVASLPSYFAKSATIYNPIIYVFMNRQFRNCILHLFGKKVDDSSELSSTSKTEVSSVSSVSPA
Protein: Tectonic-2 (Q96GX1)
Organism: Homo sapiens (Human)
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}.
Interaction partners:
- Tectonic-1
- B9 domain-containing protein 1
- Coiled-coil and C2 domain-containing protein 2A
- Meckelin
- B9 domain-containing protein 2
- Tectonic-3
- Transmembrane protein 231
- Tectonic-like complex member MKS1
- Transmembrane protein 216
- Centrosomal protein of 290 kDa
Sequence:
MGFQPPAALLLRLFLLQGILRLLWGDLAFIPPFIRMSGPAVSASLVGDTEGVTVSLAVLQDEAGILPIPTCGVLNNETEDWSVTVIPGAKVLEVTVRWKRGLDWCSSNETDSFSESPCILQTLLVSASHNSSCSAHLLIQVEIYANSSLTHNASENVTVIPNQVYQPLGPCPCNLTAGACDVRCCCDQECSSNLTTLFRRSCFTGVFGGDVNPPFDQLCSAGTTTRGVPDWFPFLCVQSPLANTPFLGYFYHGAVSPKQDSSFEVYVDTDAKDFADFGYKQGDPIMTVKKAYFTIPQVSLAGQCMQNAPVAFLHNFDVKCVTNLELYQERDGIINAKIKNVALGGIVTPKVIYEEATDLDKFITNTETPLNNGSTPRIVNVEEHYIFKWNNNTISEINVKIFRAEINAHQKGIMTQRFVVKFLSYNSGNEEELSGNPGYQLGKPVRALNINRMNNVTTLHLWQSAGRGLCTSATFKPILFGENVLSGCLLEVGINENCTQLRENAVERLDSLIQATHVAMRGNSDYADLSDGWLEIIRVDAPDPGADPLASSVNGMCLDIPAHLSIRILISDAGAVEGITQQEILGVETRFSSVNWQYQCGLTCEHKADLLPISASVQFIKIPAQLPHPLTRFQINYTEYDCNRNEVCWPQLLYPWTQYYQGELHSQCVAKGLLLLLFLTLALFLSNPWTRICKAYS
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (Q382S1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA repair protein RAD51 homolog
- Proliferating cell nuclear antigen
- DNA repair protein, putative
- S-phase kinase-associated protein, putative
- SKP1 component dimerisation domain-containing protein
- DNA 3'-5' helicase
- DNA 3'-5' helicase
- Crossover junction endonuclease MUS81
- Small ubiquitin protein, putative
- Flap endonuclease 1
Sequence:
MEHEQRVSEAGAKLKQPDVWPVEIEQILSALDNSQRVAVCENPSQPLLIIAGAGSGKTLTMASRIAFLILNNVAPQNILGLCFSRQAAETLRGRVASVLPPAMAGLAQKLKLKTFHAFGLECLRRYACIELTTEVYDARRQRDLAFTVVEKHAQYYKGVEAVVTLIDYVNKAKTKKDMRAGTELDPSRQPAYLFRFYESMLHEELNAVDFGDLEQRFLKALRPVRQRNDATSEGNNNSNSSSYSISADASSTLQLSPMAIQLRSQYTHFVVDEFQDLNEVQLECLALLAGDECRVTCVGDPNQCIYAWRGATAESFNLWRSRFPRSVIMKLETNYRSSAEIVCAVNQVTHLEQSSHKGQSGTNITLVKCKYAWEQLKLIPRIIERLRGRDRSLPYGSIAVLCRTHRTVRELVTALENDGIPVTELRRGAPNSVALVRALLSYLRLCIHPHSNVDVECVIRDAPNHFAAPSATKFIFALQAEALTRRLHLTTEQQLEGHYKCSYYTILRELVHNGFATSSDRLRTTKPQQKLLRTIIEVTAAAHEALSRFYCNIEDVVRSVAERAGFDDGSAGGAKIRHKVNNGMAGGGFNGIKRAKRPRCAPRVAAHLTDSVDVWEDVMNEGEEIMSSIPQLLLGACEAVQEQIIAEQSAVEADAINGDVLGFSDNRSVVKAEPDERSVGTHPDVPAAQPRYDPYTVLQRVIDEFLQLLPSDDFGPMKGPEALKPEERTVTVTTVHQAKGKEWPAVIIPCCYEGEFPIDTRKAEEKRVFYVAMSRAMESLVFLTAEQGPPTNASGRTADGDHALDSTGTEQQYVQLQMTPYLRPILHQVKVITMSAESEGQQE
Protein: Probable proteasome inhibitor (Q9M330)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Could play an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome (By similarity).
Interaction partners:
- Proteasome subunit beta type-4
- Proteasome subunit beta type-1
- Proteasome subunit beta type-6
- Proteasome subunit alpha type-1-A
- Proteasome subunit beta type-7-A
- Proteasome subunit beta type-7-B
- Proteasome subunit alpha type-7-A
- Proteasome subunit alpha type-7-B
- Proteasome subunit alpha type-1-B
- ARM repeat superfamily protein
Sequence:
MANSQTVMAMIRLARPPFRNNHDKVAFAIHSSFVASGYILTATGRPAFADEALSSSSQNDVGIEGWNEFEGEYAFVYANPKKGSKKILVKCLAMDDKLLVDAIADGGAEPAHLEIKVGDYAEESNEGDYSAQFKNLDKLVTDLQSEIIDKLDGKPKPVASRAQSSSETNEEPRYYDDTPNPLGPQIHPSGVVVPPIPGNGGYSDLFPGPGAGMYPGRGGFGDGSMLVGPTDPRFFPFGDGSDRPGFMGPPHPGMPPPGARFDPYGPPGVPGFEPGRFTRQPPRGPGGGHPDLEHFPGGSDFI
Protein: Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) (Q9H7P9)
Organism: Homo sapiens (Human)
Function: May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein). Involved in the regulation of actin polymerization.
Interaction partners:
- Cell division control protein 42 homolog
- Guanine nucleotide-binding protein G
- Transforming protein RhoA
Sequence:
MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGSEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHIFCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKLGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQAAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEGPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTTPALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSWHGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQVPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPHSPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPPPQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAPDAPFHM
Protein: Tubulin beta chain (Q5ST81)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA
Protein: (-)-isopiperitenol/(-)-carveol dehydrogenase, mitochondrial (EC 1.1.1.223) (EC 1.1.1.243) (Q5C9I9)
Organism: Mentha piperita (Peppermint) (Mentha aquatica x Mentha spicata)
Function: Involved in the biosynthesis of menthol and related monoterpenes in leaves. Can use (-)-trans-carveol and, with a lower relative velocity, (-)-trans-isopiperitenol, (+)-neomenthol, (+)-neoisomenthol and (-)-cis-isopiperitenol as substrates, but not (-)-cis-carvenol, (-)-menthol, (+)-isomenthol, 7-hydroxy-limonene, (-)-isopiperitenone or (-)-carvone.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:15542490}.
Interaction partners:
Sequence:
MASVKKLAGKVAIVTGGASGIGEVTARLFAERGARAVVIADMQPEKGGTVAESIGGRRCSYVHCDITDEQQVRSVVDWTAATYGGVDVMFCNAGTASATAQTVLDLDLAQFDRVMRVNARGTAACVKQAARKMVELGRGGAIICTASATVHHAGPNLTDYIMSKCGVLGLVRSASLQLGVHGIRVNSVSPTALATPLTATIGLRTAADVESFYGQVTSLKGVAITAEHVAEAVAFLASDEAAFVTGHDLAVDGGLQCLPFVAVAK
Protein: Outer membrane protein YaiO (Q47534)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:16522795}.
Interaction partners:
- Aldose sugar dehydrogenase YliI
Sequence:
MIKRTLLAAAIFSALPAYAGLTSITAGYDFTDYSGDHGNRNLAYAELVAKVENATLLFNLSQGRRDYETEHFNATRGQGAVWYKWNNWLTTRTGIAFADNTPVFARQDFRQDINLALLPKTLFTTGYRYTKYYDDVEVDAWQGGVSLYTGPVITSYRYTHYDSSDAGGSYSNMISVRLNDPRGTGYTQLWLSRGTGAYTYDWTPETRYGSMKSVSLQRIQPLTEQLNLGLTAGKVWYDTPTDDFNGLQLAARLTWKF
Protein: Neutrophil gelatinase-associated lipocalin (NGAL) (Lipocalin-2) (Oncogene 24p3) (24p3) (SV-40-induced 24p3 protein) (Siderocalin LCN2) (p25) (P11672)
Organism: Mus musculus (Mouse)
Function: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:20550936, ECO:0000269|PubMed:8687399}. Cytoplasmic granule lumen {ECO:0000250|UniProtKB:P80188}. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P80188}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (PubMed:16377569). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (By similarity). {ECO:0000250|UniProtKB:P80188, ECO:0000269|PubMed:16377569}.
Interaction partners:
- Matrix metalloproteinase-9
- Lactotransferrin
- Solute carrier family 22 member 17
- Hepatitis A virus cellular receptor 1 homolog
- Low-density lipoprotein receptor-related protein 2
- Melanocortin receptor 4
- Fibronectin
- Hepcidin
- Cystatin-C
- Hepcidin-2
Sequence:
MALSVMCLGLALLGVLQSQAQDSTQNLIPAPSLLTVPLQPDFRSDQFRGRWYVVGLAGNAVQKKTEGSFTMYSTIYELQENNSYNVTSILVRDQDQGCRYWIRTFVPSSRAGQFTLGNMHRYPQVQSYNVQVATTDYNQFAMVFFRKTSENKQYFKITLYGRTKELSPELKERFTRFAKSLGLKDDNIIFSVPTDQCIDN
Protein: IGF-II mRNA-binding protein, isoform D (IGF-II mRNA-binding protein, isoform E) (IGF-II mRNA-binding protein, isoform F) (IGF-II mRNA-binding protein, isoform G) (IGF-II mRNA-binding protein, isoform H) (Q8IR99)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASELDQFADLELSKEDREQIFDPPLDRQQLEGAGTSRAAVGLNGVEFEGSKLHAEQLDKNQRRSQRNQRNPYPGMPGPGRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPENCTNACKRILEVMQQEAISTNKGEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSINDINSFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMMSTPGNGMVFNTSMPFPSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAIIGTRGSHIRSIMRFSNASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQVGRIIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETPVHIIGLFYSVQSAQRRIRAMMLSTNPPPITKKQKAAKEQLQQQQQSLAGAASSGSQQQQPQSPSQQQALPPQLHHQPVSSASSSSTPPAHHQQQASTAATSHQLQQQQPSPPPPGNATAAAAQQQQQLASSQQ
Protein: 14-3-3 protein eta (Protein AS1) (Q04917)
Organism: Homo sapiens (Human)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Interaction partners:
- RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
- M-phase inducer phosphatase 3
- M-phase inducer phosphatase 2
- Serine/threonine-protein kinase A-Raf
- Transcriptional coactivator YAP1
- Bcl2-associated agonist of cell death
- 14-3-3 protein zeta/delta
- 14-3-3 protein gamma
- 14-3-3 protein beta/alpha
Sequence:
MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN
Protein: Alpha-galactosidase 3 (AtAGAL3) (EC 3.2.1.22) (Alpha-D-galactoside galactohydrolase 3) (Melibiase) (Q8VXZ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May regulate leaf (and possibly other organ) development by functioning in cell wall loosening and cell wall expansion.
Subcellular location: Secreted, cell wall {ECO:0000250|UniProtKB:Q8RX86}. Secreted, extracellular space, apoplast {ECO:0000250|UniProtKB:Q8RX86}. Vacuole {ECO:0000305|PubMed:12773619}.
Interaction partners:
- Probable galactinol--sucrose galactosyltransferase 5
- Probable galactinol--sucrose galactosyltransferase 2
- Probable galactinol--sucrose galactosyltransferase 1
- Probable galactinol--sucrose galactosyltransferase 6
- alpha-D-xyloside xylohydrolase
- Probable galactinol--sucrose galactosyltransferase 4
- beta-galactosidase
- Beta-hexosaminidase 1
- Beta-hexosaminidase 3
- Aldose 1-epimerase
Sequence:
MVIMKKMKDSVLFLVVGLFSLSVLVSQSIAGRVKAPLLQSNTGGLVFSKSFNSIYDTSMYGRLQLNNGLARTPQMGWNSWNFFACNINETVIKETADALVSSGLADLGYIHVNIDDCWSNLLRDSEGQLVPHPETFPSGIKLLADYVHSKGLKLGIYSDAGVFTCEVHPGSLFHEVDDADIFASWGVDYLKYDNCFNLGIKPIERYPPMRDALNATGRSIFYSLCEWGVDDPALWAKEVGNSWRTTDDINDTWASMTTIADLNNKWAAYAGPGGWNDPDMLEIGNGGMTYEEYRGHFSIWALMKAPLLIGCDVRNMTAETLEILSNKEIIAVNQDPLGVQGRKIQANGENDCQQVWSGPLSGDRMVVALWNRCSEPATITASWDMIGLESTISVSVRDLWQHKDVTENTSGSFEAQVDAHDCHMYVLTPQTVSHSDV
Protein: Transmembrane channel-like protein 1 (Beethoven protein) (Deafness protein) (Transmembrane cochlear-expressed protein 1) (Q8R4P5)
Organism: Mus musculus (Mouse)
Function: Probable ion channel required for the normal function of cochlear hair cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25114259, ECO:0000269|PubMed:28534737}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia tips of the cochlear hair cells. {ECO:0000269|PubMed:28504928, ECO:0000269|PubMed:38228630}.
Interaction partners:
- LHFPL tetraspan subfamily member 5 protein
- Calcium and integrin-binding family member 2
- Transmembrane inner ear expressed protein
- Protocadherin-15
- Transmembrane channel-like protein 2
- Calcium and integrin-binding family member 3
- Cadherin-23
- Unconventional myosin-VIIa
- pre-mRNA splicing regulator USH1G
- Whirlin
Sequence:
MLQIQVEEKEEDTEESSSEEEEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDEETRKAREKERRRRLRRGAEEEEEIDEEELERLKALLDENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKMRNKKMAAARAAAAAGGQ
Protein: Processive diacylglycerol alpha-glucosyltransferase (EC 2.4.1.208) (EC 2.4.1.337) (Alpha-diglucosyldiacylglycerol synthase) (Alpha-DGS) (DGlcDAG synthase) (Alpha-monoglucosyldiacylglycerol synthase) (Alpha-MGS) (MGlcDAG synthase) (Glucosyl-alpha-1,2-glucosyldiacylglycerol synthase) (UDP-glucose:1,2-diacylglycerol 3-alpha-D-glucosyltransferase) (Q8KQL6)
Organism: Acholeplasma laidlawii
Function: Processive glucosyltransferase involved in the biosynthesis of both the non-bilayer-prone alpha-monoglucosyldiacylglycerol and the bilayer-forming membrane lipid alpha-diglucosyldiacylglycerol. These are major components for maintaining the anionic lipid surface charge density, for balancing the bilayer to non-bilayer phase equilibria and for keeping a constant lipid bilayer spontaneous curvature (curvature packing stress). Catalyzes the transfer of a glucosyl residue from UDP-Glc to diacylglycerol (DAG) acceptor to form the corresponding alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol), which then acts as acceptor to give alpha-diglucosyl-DAG product (3-O-(alpha-D-glucopyranosyl-alpha-(1->2)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol). It can only use UDP-Glc as sugar donor.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12464611, ECO:0000269|PubMed:1533160}.
Interaction partners:
Sequence:
MKVLLYSQKQSMLKKSGIGRAFYHQKRALEAVGIEYTTDPKDTYDLVHVNIAHSNKIKKFRKKYPVIVHGHSTVQDFRRSFAFWRVIAPFFYKHLQNIYGIADLIITPTRYSKFLIESMHVVKSPVVALSNGIDLDAYEYKQENVDAFRKHFDLEPNQKVVIGVGLLFERKGIHDFIEVARTMPNVTFIWFGNLSKLATTHFIRKRIKNKPKNMIMPGYVDGAVIKGAFSGADCVFFPSYEETEGIVVLEGLASKTPVVLRDIPVYYDWLFHKEHVLKGHNNFEFSKLIEKVLHEDQTEMIENGYKIVQDRSIEKIGEGLKQAYQEVIKIKR
Protein: Probable protein phosphatase 2C 49 (AtPP2C49) (EC 3.1.3.16) (Q3EAF9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pentatricopeptide repeat-containing protein At3g04760
- Defensin-like protein 11
- C2H2-type zinc finger family protein
- Duplicated homeodomain-like superfamily protein
- Probable histone H2A.2
- Probable transcription factor At4g00130
- Putative ribosomal large subunit pseudouridine synthase SVR1, chloroplastic
- AGAMOUS-like 57
- Probable protein phosphatase 2C 4
Sequence:
MVAEAEVVFQQSLPAVLEIELFDGVSSAVKSPVSSPKLGFTQSTASVSGSLTTSPVQADIFPEGDCDPSVLDYIPTIRSGSFADIGPKRNMEDEHIRIDDLSSQVGSLFELPKPSAFYAVFDGHGGPEAAAYVRENAIRFFFEDEQFPQTSEVSSVYVEEVETSLRNAFLQADLALAEDCSISDSCGTTALTALICGRLLMVANAGDCRAVLCRKGRAIDMSEDHKPINLLERRRVEESGGFITNDGYLNEVLAVTRALGDWDLKLPHGSQSPLISEPEIKQITLTEDDEFLVIGCDGIWDVLTSQEAVSIVRRGLNRHNDPTRCARELVMEALGRNSFDNLTAVVVCFMTMDRGDKPVVPLEKRRCFSLSPEAFCSLRNLLDG
Protein: PIP-1 (RRM domain-containing protein) (G5EF02)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Non-structural maintenance of chromosomes element 4
- Alpha/beta hydrolase fold-3 domain-containing protein
- EGF-like domain-containing protein
- Meiotic spindle formation protein 2
- F-box associated domain-containing protein
- RNA-binding protein pos-1
- K Homology domain-containing protein
- Pumilio domain-containing protein 5
- Female germline-specific tumor suppressor gld-1
- Zinc finger protein mex-5
Sequence:
MQNTQIFTNFAHRAHDGLPFNSANPSNKDPIFTMPISVKPKTREPASFTDNRIYVSNIPFSFREQDLAAMFFAYGRVLSVEIVTNDRGSKGFGFVTLDSIESCEKARAALHESHVQGRIIEVRRATPTRRKLINNPQNEVLPPPKLCVDLRAPHNLWRAEPMHQLFKEKENTTCFPEAGFMMAPYRSNGIFNTRSLVQTKPPRCTKHSELKLSSAGEYFCKNGEPTTETSILMCMHRQNSPCSNKCSDSSNHELSDVELNSIFPHHLRDQITALLDTSNHFGSGNNSANKGKRAPSVTSSGLRSSESETVSDEEIHWSPHNSPDYLLAALYEGSTSFHGKSVSPPKESSSQ
Protein: Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)] (Q9WTX4)
Organism: Mus musculus (Mouse)
Function: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Subcellular location: [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-4]: Secreted {ECO:0000250}.
Interaction partners:
- Receptor tyrosine-protein kinase erbB-4
- Pro-neuregulin-2, membrane-bound isoform
- Pro-neuregulin-1, membrane-bound isoform
- Pro-neuregulin-3, membrane-bound isoform
- Receptor tyrosine-protein kinase erbB-3
- Epidermal growth factor receptor
- Receptor tyrosine-protein kinase erbB-2
Sequence:
MPTDHEQPCGPRHRSFCLNGGICYVIPTIPSPFCRCIENYTGARCEEVFLPSSSIPSESNLSAAFVVLAVLLTLTIAALCFLCRKGHLQRASSVQCEISLVETNNTRTRHSHREH