wanglab/gogpt-training-data huggingface dataset:
Protein: Nucleomorphin (Calmodulin-binding protein A) (Calmodulin-binding protein CaM-BP38) (Q9U7C9)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000269|PubMed:11919178, ECO:0000269|PubMed:15896312}.
Interaction partners:
- Myb domain-containing protein
- Enhancer of polycomb-like protein
- Probable transcription-associated protein 1
- NuA4 complex subunit EAF3 homolog
- Histone H4
- PHD zinc finger-containing protein
- Chromatin modification-related protein EAF6
- Actin-like protein 6A
- PHD zinc finger-containing protein
- Calcium-binding protein 4a
Sequence:
MDLDYSSDNSRLVADNQNNKTNTKNQSQLSTSSQIPQTSQSYQQQQQHNQQQQQQQQQKQNSRPSSPKTIQAKVNNNNNNNNNNNNNNNNNNNNGATISHPPTSQSNEDLSSSAEIHHDDSAQLNSNIFENLGFVIDITINLKRKMELVKIIKKNGGKSCYSCTKATHLITTKQGYLEKTQKVTQAISLGIPILVKEYVHYCAFKKELLGVENYLVSSLILNPTSTTLNSSQDLIEKPNEEEPQNGTINEQPIAMTIDNTLESNKPIETIQPSSLEKQEPKETELQTQQQPQTELKSELEPQQLQLIQEKDKNINNLSIDSNHMDTSKIEAGNNISNQTQSNIISSVVQTIEPLKECNKIDLDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSSNNKNKNNVDEAQEGLNINSVMDVHLTSSTSSTLSSSDNQDNELLRDEGTTPKSKKKFSQKKNHLLNLKKSYQDPEIIAHSRPRKSSGGVSLVEALSDHANYISNLDGFKYYARANKSSLNSNATTSGGNNRSIKLNEYKYDDEEEDEEDEDEEDEEEDEEEEEEEEEEEEDYDDEDLNDEESDEDDFDSDEDVSRFIKGKLLQKQQKIYKDLERFEHSRQQQHHHHQSSQVNSSKPRSRSHSRDYIESEIAKYLLNNSEKQIPLSPTKKRSLSNQFHQDGGNNTTDGNLFNNFSTNGGGNRTNIDDSIKQSILESPSSSSLKSSKSKKSKKPFLPPLSTLVHILVTFIILSAFFMSLPSN
Protein: Meiosis-specific protein HOP1 (P20050)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable constituent of the synaptonemal complex during meiosis. May interact with RED1.
Subcellular location: Nucleus. Chromosome. Note=Synapsis of meiotic chromosomes.
Interaction partners:
- Protein RED1
- Meiosis-specific serine/threonine-protein kinase MEK1
- Meiotic recombination protein REC8
- Meiotic recombination protein DMC1
- Meiosis-specific protein SPO11
- Synaptonemal complex protein ZIP1
- Meiosis-specific protein SPO13
- Pachytene checkpoint protein 2
- DNA repair protein RAD51
- Sporulation-specific protein 22
Sequence:
MSNKQLVKPKTETKTEITTEQSQKLLQTMLTMSFGCLAFLRGLFPDDIFVDQRFVPEKVEKNYNKQNTSQNNSIKIKTLIRGKSAQADLLLDWLEKGVFKSIRLKCLKALSLGIFLEDPTDLLENYIFSFDYDEENNVNINVNLSGNKKGSKNADPENETISLLDSRRMVQQLMRRFIIITQSLEPLPQKKFLTMRLMFNDNVDEDYQPELFKDATFDKRATLKVPTNLDNDAIDVGTLNTKHHKVALSVLSAATSSMEKAGNTNFIRVDPFDLILQQQEENKLEESVPTKPQNFVTSQTTNVLGNLLNSSQASIQPTQFVSNNPVTGICSCECGLEVPKAATVLKTCKSCRKTLHGICYGNFLHSSIEKCFTCIFGPSLDTKWSKFQDLMMIRKVFRFLVRKKKGFPASITELIDSFINVEDQNNEVKERVAFALFVFFLDETLCLDNGGKPSQTIRYVTSSVLVDVKGIVIPNTRKQLNVNHEYKWHFTTSSPKAESFYQEVLPNSRKQVESWLQDITNLRKVYSEALSPSSTLQELDLNSSLPTQDPIISGQKRRRYDLDEYLEEDKSSVVNDTIKAKDFDESVPAKIRKISVSKKTLKSNW
Protein: Glycine betaine/carnitine transport permease protein GbuB (Q9RR45)
Organism: Listeria monocytogenes serotype 1/2a (strain 10403S)
Function: Part of the ABC transporter complex GbuABC involved in glycine betaine uptake. Responsible for the translocation of the substrate across the membrane. Involved, with BetL and OpuC, in osmoprotection and cryoprotection of Listeria. Can also uptake carnitine when carnitine is abundant in the growth medium.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
Sequence:
MPNIPTIPLASWIDKLVDGLTQFEGFFNVITNIIGGIVDAFQWVFDLVPPWLFIILLVFGTFWVNRKGKKWGLIIFEVVGLLLIWNLDFWRDMTQTLTLVLTSSLIALVIGVPLGIWMAKSNIVESIFKPVLDFMQTMPAFVYLIPAVAFFGIGMVPGVVASVIFAMPPTVRMTNLGIRQVSTELVEAADSFGSTPWQKLWKVQLPMAKSTMMAGINQSIMLALSMVVIASMIGAMGLGTRVYFAVGRNDAGGGFVAGIAIVIVAIILDRLTQAFNKKAKSE
Protein: Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15) (P90) (Q61586)
Organism: Mus musculus (Mouse)
Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9HCL2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9HCL2}. Note=Associated with the mitochondrion outer membrane of hepatic cells via a patch of basic residues. {ECO:0000250|UniProtKB:Q9HCL2}.
Interaction partners:
- Glycerol-3-phosphate acyltransferase 4
- Glycerol-3-phosphate acyltransferase 3
- Glycerol kinase
- Glycerol kinase 2
- glycerol kinase
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase 1-like protein
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
- Glycerol-3-phosphate acyltransferase 2, mitochondrial
Sequence:
MEESSVTVGTIDVSYLPSSSEYSLGRCKHTSEDWVDCGFKPTFFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWERFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYILFVQERDVHKGMFATSVTENVLSSSRVQEAIAEVAAELNPDGSAQQQSKAIQKVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRLDETPDGRKDILYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGYVRVDFAQPFSLKEYLEGQSQKPVSAPLSLEQALLPAILPSRPNDVADEHQDLSSNESRNPADEAFRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIHLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRKDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSIYAVLNKRCSGGSAGGLGNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAEQDDQEDVSPGLAEQQWDKKLPELNWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAIFVHNFSGPVPESEYLQKLHRYLITRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKQKRVSVLELSSTFLPQCNRQKLLEYILSFVVL
Protein: Interleukin-20 receptor subunit beta (A0A142K3A7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLALAVAQRSASLLNFVPDAVSVLPAPQNLSVQSTNMKHLLMWNPVTQPGETVLYCVEYQGEYESLYMSHIWIPSSQCSPTKSLECDVTDDITATVPYNFRVKAMLGSQTSAWSNLEHPFNRNATVLTPPRMEVTEHGLHLVIELEDLGPQFEFLVVYWRREPGAAEHVKMVRSGDIPVHLETMEPGAMYCVKAQALVKAIGRHSAFSQPTCVEMQGESLPLALALFAFVGFMLILVVVLLSVWKMGQLLRYSCCPAVVLPDTLKITSSSQKLISCRKEEVDACAVAVLSSEHLFGVWISQT
Protein: Transforming acidic coiled-coil containing protein 1 (E5RFM9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MGGSHSQTPRGREPAGERHPRPTETASDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD
Protein: Ubinuclein 1 (K7EJT1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XSDEEEDEEKGGRRIMGPRKKFQWNDEIRTLFKESRRGHGHLTSILAKKKVMAPSKIKVKESSTKPDKKVSVPSGQIGGPIALPSDHQTGGLSIGASSRELPSQASGGLANPPPVNLEDSLDEDLIRNPASSVEAVSKELAALNSRAAGNSEFTLPAPSKAPAEKVGGVLCTEEKRNFAKPSPSAPPPASSLQSPLNFLAEQALALGQSSQEKKPESSGYKELSCQAPLNKGLPEVHQSKAKHHSLPRTSHGPQVAVPVPGPQVKVFHAGTQQQKNFTPPSPFANKLQGPKASPTQCHRSLLQLVKTAAKGQ
Protein: Mitochondrial import inner membrane translocase subunit TIM12 (Mitochondrial regulator of splicing 5) (P32830)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. In the TIM22 complex, it acts as a docking point for the soluble TIM9-TIM10 heterohexamer that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:8663351, ECO:0000269|PubMed:9495346}; Peripheral membrane protein {ECO:0000269|PubMed:8663351, ECO:0000269|PubMed:9495346}. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM10
- Mitochondrial import inner membrane translocase subunit TIM18
- Mitochondrial import inner membrane translocase subunit TIM22
- Mitochondrial import inner membrane translocase subunit TIM9
- Mitochondrial import inner membrane translocase subunit TIM54
- Mitogen-activated protein kinase FUS3
- Succinate dehydrogenase cytochrome b subunit
- Mitochondrial import inner membrane translocase subunit TIM8
- Mitochondrial import inner membrane translocase subunit TIM13
- Mitochondrial intermembrane space import and assembly protein 40
Sequence:
MSFFLNSLRGNQEVSQEKLDVAGVQFDAMCSTFNNILSTCLEKCIPHEGFGEPDLTKGEQCCIDRCVAKMHYSNRLIGGFVQTRGFGPENQLRHYSRFVAKEIADDSKK
Protein: Cellulase CelDZ1 (EC 3.2.1.4) (A0A0U4EBH5)
Organism: Thermoanaerobacterium sp
Function: Thermostable endoglucanase that has high activity with soluble polymeric substrates containing beta-1,4-glycosidic bonds, such as carboxymethyl cellulose (CMC) and barley beta-D-glucan (in vitro). Has no activity with cellobiose and filter paper. Has no activity with substrates containing beta-1,3-linked glycans, such as laminarin. Likewise, lacks activity with xylan, galactomannan and pectin.
Subcellular location: Cell membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MNKWHINKWYFFVGMLVIFAVIISLILKDTSLTFSSYDREKFPHLIGNSMVKKPSLAGRLKIIEIDGRKTLGDQHGNPIQLRGMSTHGLQWFPQIINNNAFSALSKDWEANVIRLAMYVGEGGYSTDPSVKEKVIEGINLAIKNDMYVIVDWHILNPGDPNAKIYSGAKEFFKEIASKYPNDLHIIYELANEPNPTESDITNDIAGWEKVKKYAEPIIKMLRDMGNENIIIVGNPEWSTRPDLAVNDPIDDKNVMYSAHFYTGSASVWENGNKGHIARNIEKALENGLTVFVTEWGTSEASGDGGPYLNEADEWLEFLNSNNISWVNWSLANKNEASAAFLPTTSLDPGNGKVWAVNQLSLSGEYVRARIKGIPYKPISRETMGK
Protein: Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (Q04771)
Organism: Homo sapiens (Human)
Function: Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Bone morphogenetic protein 6
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein 7
- Activin receptor type-2A
- Bone morphogenetic protein receptor type-2
- Peptidyl-prolyl cis-trans isomerase FKBP1A
- Bone morphogenetic protein 4
- Bone morphogenetic protein receptor type-1B
- Mothers against decapentaplegic homolog 5
- Activin receptor type-2B
Sequence:
MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
Protein: Azole resistance protein 1 (P50080)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transporter protein required for adaptation to high stress imposed by low-chain organic acids, in particular by acetic acid, and for resistance to azoles, especially to ketoconazole and fluconazole.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11113970}; Multi-pass membrane protein {ECO:0000269|PubMed:11113970}.
Interaction partners:
- Probable transporter AQR1
- Uncharacterized transporter YMR279C
- Polyamine transporter 2
- Aminotriazole resistance protein
- Fluconazole resistance protein 1
- Oligomycin resistance ATP-dependent permease YOR1
- ABC transporter ATP-binding protein/permease PDR18
- Quinidine resistance protein 3
- Protein SNQ2
- Polyamine transporter 3
Sequence:
MKGEPKTYSMSDLSYYGEKAQQQNEKQQKQYVVRRNSTQSTSKQNVSVVLEDNASESNELPKGFILYASLIALALSLFLAALDIMIVSTIIEEVAKQFGSYSEIGWLFTGYSLPNALLALIWGRIATPIGFKETMLFAIVIFEIGSLISALANSMSMLIGGRVIAGVGGCGIQSLSFVIGSTLVEESQRGILIAVLSCSFAIASVVGPFLGGVFTSSVTWRWCFYVNLPIGGLAFFLFLFFYNPGLSTFQETMDNIRKFPSQFIEIVRNVAYHLLKIKGFSKLNGWRKPFMELIFMYDIIEFVFCSAGFTCILLAFTFGGNRYAWNSASIIILFIIGIVLVVLAGIYDFLVFPKFNIVKATPHYQPLMSWTNIKKPGIFTVNIALFLTCAGYISQFTYIVQYFQLIYNDSAWRAAVHLVACIISTVVTAILCGAITDKTRQIKPIIVISSIFGVVGAGILTLLNNNANNSAHIGLLILPGVAFGGLAQSSMLASQIQLDKKSPTFRSDFVSITTFNTFCKNLGQALGGVISNTVFSAAAIKKLTKANIQLPDGTTVDNLVIYRQTNFDGSHSKLGNIISESLTDVFYMALGFYALSLIFAVFASNKKVTASLR
Protein: DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) (P38935)
Organism: Homo sapiens (Human)
Function: 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. Specific to 5'-phosphorylated single-stranded guanine-rich sequences. May play a role in RNA metabolism, ribosome biogenesis or initiation of translation. May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr.
Subcellular location: Nucleus {ECO:0000269|PubMed:19299493}. Cytoplasm {ECO:0000269|PubMed:19299493}. Cell projection, axon {ECO:0000250|UniProtKB:P40694}.
Interaction partners:
- Activator of basal transcription 1
- Negative elongation factor E
- General transcription factor 3C polypeptide 1
- Survival motor neuron protein
- Negative elongation factor A
- Ganglioside-induced differentiation-associated protein 1
Sequence:
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVGLYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPASEIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKQRILRLGHPARLLESIQQHSLDAVLARSDSAQIVADIRKDIDQVFVKNKKTQDKREKSNFRNEIKLLRKELKEREEAAMLESLTSANVVLATNTGASADGPLKLLPESYFDVVVIDECAQALEASCWIPLLKARKCILAGDHKQLPPTTVSHKAALAGLSLSLMERLAEEYGARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRDLPGVAATEETGVPLLLVDTAGCGLFELEEEDEQSKGNPGEVRLVSLHIQALVDAGVPARDIAVVSPYNLQVDLLRQSLVHRHPELEIKSVDGFQGREKEAVILSFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRTAFEYLDDIVPENYSHENSQGSSHAATKPQGPATSTRTGSQRQEGGQEAAAPARQGRKKPAGKSLASEAPSQPSLNGGSPEGVESQDGVDHFRAMIVEFMASKKMQLEFPPSLNSHDRLRVHQIAEEHGLRHDSSGEGKRRFITVSKRAPRPRAALGPPAGTGGPAPLQPVPPTPAQTEQPPREQRGPDQPDLRTLHLERLQRVRSAQGQPASKEQQASGQQKLPEKKKKKAKGHPATDLPTEEDFEALVSAAVKADNTCGFAKCTAGVTTLGQFCQLCSRRYCLSHHLPEIHGCGERARAHARQRISREGVLYAGSGTKNGSLDPAKRAQLQRRLDKKLSELSNQRTSRRKERGT
Protein: Echinus splice form 1 (Echinus, isoform B) (Q1W9Q0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSAHSGRRMTTPGTLYRLASGSAATPATPTNSPYGQPAKPYAVGSIQNGSERNRILELLRAPNSLTSPTLEPSSKGLLNGPGQNNCFLNCAVQVLWHLDAFRRSFRGLNQHVCGGQDCIFCALKELFQQLQTSSEPALCPEPLRRALASGPLAGRRFPLGCLGDAAECFELLLHRVHSHISPDDGDSCESSACIAHRRFAMRVIEQSVCKCGANSEQLPFTQMVHYVSASALTSQKSLALQSHQQLSFGQLLRAAGNMGDIRDCPNTCGAKIGICRALLNRPEVVSIGIVWDSERPAADQVHAVLKAVGTSLRLGDVFHQVSEPRWAQQTQHELVGIVSYYGKHYTTFFFHTKLKVWVYFDDANVKEVGPSWEGVVDKCSRGRYQPLLLLYAVPQQPTVGNGVGIGHVDVAMPASAPSIAGSVVRRAVTPSPEKPSLGNTRRAITPTPLRTPPNDYQNLSVIQKNIFPSNLAMGTDETDAYISRKTVEHVLSAQYQNLSVIQDKIGGGNGVGVGQQSVDKDGGFLSRKPIEAVLSAQLARRQHLQLQRSHSAESSSGHASSNGSSPPSDGLTMPEHLNQPRRRDSGNWSGDRNSASSASSTTLDNPYLYMVAKRGVAAVPQSPTRHGLPYDPGYDSFSLSSTDSYPPKHALNPQLAKIPEAAMGVVPNGGAMPHGHGNGQLALSGDCEKLCHEADQLLEKSRLVEESHDLETALVLCNAAAGRARAAMDAPYSNPHTMTFARMKHNTCVMRARSLHRRILVEKGAETEAMPELKHMREGSTSSVKHVRQNSKDRTLEKEQQQLQFQQIQQIQQIHQIQQQIPASIEIYATLPKRKSPLKALASASACDDNAIEYEQEKQLATSPGKPERESRSLFGRKDKEKEKRSRSEDRNKLTREFSLTETLLVNAKDTLKKHKEDKDEKKEKDKSGKKQHKIRRKLLMGGLIRRKNRSMPDLTEAVDDSTANAGITHHPHYPAQGVTTAGTLLGTSVDDSAVGLGKHGHGMSGYISEGHFDYSGSGSASNSGAGSNPNPNLERSKLMRKSFHGSGRQLTMVPKVAPPPPMRTSSTLTPQQQQQQQQQFHHEANLSNLSAMSSNTSISEDSCQTIITTCAQVHSEQSPLKDLQMLVAQDELPLPPPMELPPYPSPPHSSCHSRQASEDFPPPPPPELDLEPLNQQLSQLQALEAASKQQRQQLESLEGTTSILAQLQQRQHLLKLRKEQANHPGAATTDATWLKELQAKQANDLRAMQRKLEASSPSSVRDLTHRFEQTSIRSYASQELLSQPGQSQQLGQLRTQMNGLPNGNAKMDVDEVDAMPAVRNSLPAALSAHQLLPKPKYEMTQSQIAEEIREVELLNTMVQQTLNQNGAAALPKRVKKKSVSFCDQVILVATAGNEEDDDFIPNPILERVLRTAQHPNEKVTAQMIQQQQQNMMRLQTEAQPRQQQVQQLQQPSPMLGRPAGATADMQRYVQRMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQELYRQQQLHRTSMSGIASQQHLQQLDAQYTTMPRPLHHSQLGSYSVTLQKHQQLQQQQQQQQQQQAPQQLSLGYFSNGSVATSEQVPLPSPYQRVPLPHGYQPAAAGPYYPLPNAQQHLQQQQLMAKPVQKKVSFEPGTKGEADCLPPPPPPPQKNGLPETGSAGSGHPGAAPGASGAGGTTSAGITAIPTRVYNNAIVKASAKAVECNLCRKRHVIAPAVYCTNCEYYLQMLNQRR
Protein: DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32) (Q5QP82)
Organism: Homo sapiens (Human)
Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Interaction partners:
- DNA damage-binding protein 1
- Cullin-4B
- Cullin-4A
- DDB1- and CUL4-associated factor 5
- DDB1- and CUL4-associated factor 4
- DDB1- and CUL4-associated factor 12
- Activating molecule in BECN1-regulated autophagy protein 1
- DDB1- and CUL4-associated factor 6
- DDB1- and CUL4-associated factor 15
- DDB1- and CUL4-associated factor 1
Sequence:
MFPFGPHSPGGDGSAGAGAEEPTPHEGQAAATGPPSPLHPGADATHPPPPARSPRRPGAPSLSPAPRSGELGLPGAPESSTASAPGEPSPPSPPCRRPGPDCRAKSRGRHGLGAGLGGPGARLFGWLKERSLGRGLFVDPARDNFRTMTSLYGSIHPADSVYLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHKKFFHTRFLMRMRLTPDCSKMLISTSSGYLLILHDLDLTKSLEVGSYPILRARRTTSSSDLTTSSSSSGPRVSGSPCHHSDSNSSEKHMSRASQREGVSPRNSLEVVTPEVLGESDHGNCITSLQLHPKGWATLLRCSSNSDDEECTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF
Protein: Flowering locus K homology domain (Flowering locus KH domain) (Q9SR13)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates positively flowering by repressing FLC expression and post-transcriptional modification.
Subcellular location: Nucleus {ECO:0000269|PubMed:15310842}. Cytoplasm {ECO:0000269|PubMed:15310842}.
Interaction partners:
- WD-40 repeat-containing protein MSI4
- Flowering time control protein FPA
- Zinc finger CCCH domain-containing protein 37
- Flowering time control protein FCA
- Inactive protein FRIGIDA
- Polyadenylation and cleavage factor homolog 4
- MADS-box protein SOC1
- ENHANCER OF AG-4 protein 2
- Protein VERNALIZATION INSENSITIVE 3
- Polycomb group protein VERNALIZATION 2
Sequence:
MAEAEDQQNFVAHNGDQVPDQGSDELHNGLPYQVHDETLVHQPYEVEDPILEPQQYEVPDPTLEPQQYEVPDQTLEPQQYEVDDQLEYHQYQLQDQANEDVQDHSQDDLQYQPQNQEQFQLQDEAHDQAQYQAQGDVQDHNGDEVQDKVEDEEGIPEHLESLQKSEPEEDATVGGEEKRWPGWPGETVFRMLVPAQKVGSIIGRKGDVIKKIVEETRARIKILDGPPGTTERAVMVSGKEEPESSLPPSMDGLLRVHMRIVDGLDGEASQAPPPSKVSTRLLVPASQAGSLIGKQGGTVKAIQEASACIVRVLGSEDLPVFALQDDRVVEVVGEPTSVHRALELIASHLRKFLVDRSIIPFFENQMQKPTRQMDHMPPPHQSWGPPQGHAPSVGGGGYGHNPPPYMQPPPRHDSYYPPPEMRQPPMEKQPHQGISAYGREPPMNVHVSSAPPMVAQQVTQQMQIPLSYADAVIGTSGSNISYTRRLSGATVTIQETRGVPGEMTVEVSGTGSQVQTAVQLIQNFMAEAGAPAPAQPQTVAPEQQGYNPYATHGSVYAAAPTNPPGGYATDYSSGYGY
Protein: SSD domain-containing protein (P91184)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ground-like domain-containing protein
- Ground-like domain-containing protein
Sequence:
MSEDRVEQHDKQPMSDSDPLNTEKEHVLETEEPERAVSAMDNRQEKLNCLHGFLSLRRMFYLVGYSVGRYPHAYLIVAFLISINSLGMYRMVLKDRIRDGYTPTNAPSRYETDVLREFYNISGDPAMTIMILMPKNGTSMHAKANLDEAEKLSKFFFNEFNASRDGRTLRFSQLCEPYCQINKVFDLYKSAYDEQYKLFTTERRISKSSNLSYPLATMSGFDIHLERSLFGVELNPKTEENTTKLTTSDMPPHRIITNMKHVEVIVFIFRGDRDSADKEKDLSRWELDAYEWSLNEHKSDIVEVQIVGTDVLDNEMMKDGRRLTPFFAAGFGFEITFVSLCVILTAVYHNCLDQGKLLISLGAVLCPILAITSTYGIVSILGMRTNSFMLVMPFLVMGIGVDSCFLMIHSWQKERRAQASGTGNRLGMVYESVGPSITITSLTDFLSFAIGALAPTPETRLFCIASSIALALTYILQLVLFGPILAVATRYEHKTTTTSNCNWRKWLKACWKKCINVYCKILSNKFFAVVVMLGTAIYWYFAIYGLMTMKTRLDAVKILPKDSPLQRPNLVLTNLVWANYHPVTILINAPLDLENRHQMDRYWNMVDEFEKMHNCKGKASTLSWLRDYIKFSYHGEPFNLFAFFGLMTPEVYEEVDPYQANITTAKLPEFLKSPFFKHWDSFIHYHYEEGVIKLDRFMMNVAYDNTSSWDTRIQLMTDWRKVANNYSDLNVTVWEPNGMFVDQMLSLGRTATQTGIWTLVCMAVVCAIFIPNPCSIITATVSIASITTGVMGFLSLWSFDLDPVVMAAVLMSIGLSVDFIAHVAYHFQLAHRKEIRNGKIKKIPLKGSTERLEHTLGAVAWPMIQAGVSTICCILPLLFRASYSPSVFVAAIFLVVTFGMLHGLLILPTFLAALPESVTTANCYRVFLSSSSERSCRYVPRRDSTNSIELQKMERKDSLLN
Protein: ZNF277 protein (Q8WWA6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQEDRDGSCSTVGGVGYGDSKDCILEPLSLPESPGGTTTLEGSPSVPCIFCEEHFPVAEQDKLLKHMIIEHKIVIADVKLVADFQRYILYWRKRFTEQPITDFCSVIRINSTAPFEEQENYFLLCDVLPEDRILREELQKQRLREILEQQQQERNDTNFHGVCMFCNEEFLGNRSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQKKLDNLQCLYCEKTFRDKNTLKDHMRKKQHRKINPKNREYDRFYVINYLVRLSFHNLKFDCSTANKIFLRTN
Protein: G1/S-specific cyclin-E2 (Q9Z238)
Organism: Mus musculus (Mouse)
Function: Essential for the control of the cell cycle at the late G1 and early S phase.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O96020}.
Interaction partners:
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase inhibitor 1
- Cyclin-dependent kinase inhibitor 1B
- M-phase inducer phosphatase 1
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase inhibitor 1C
- S-phase kinase-associated protein 2
- Retinoblastoma-associated protein
- Cyclin-dependent kinase 6
- Retinoblastoma-like protein 2
Sequence:
MSRRSSRLQAKQHAQPNQPDSPQETQIIQAKKRKTAQDVKKRKEEITKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWACSQEVWQNMLQKENRYVHDKHFQVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWELCPVTVISWLNLFLQVDAVKDVPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWDDISECVDWMVPFVSVVKSVSPVKLKTFKKIPMEDRHNIQTHTNYLALLNEVNYVNIYRKGGQLSPVCNGGIMTPPKSTEKPPGKH
Protein: DNA replication complex GINS protein PSF3 (GINS complex subunit 3) (Q9BRX5)
Organism: Homo sapiens (Human)
Function: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Subcellular location: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
Interaction partners:
- DNA replication complex GINS protein PSF1
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM2
- DNA replication licensing factor MCM6
- DNA replication complex GINS protein PSF2
- DNA replication licensing factor MCM3
- Cell division control protein 45 homolog
- DNA replication licensing factor MCM4
- DNA replication complex GINS protein SLD5
- DNA replication licensing factor MCM5
Sequence:
MSEAYFRVESGALGPEENFLSLDDILMSHEKLPVRTETAMPRLGAFFLERSAGAETDNAVPQGSKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADPNVVDLHKMGPHFYGFGSQLLHFDSPENADISQSLLQTFIGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQTGQKGLNDFQCWEKGQASQITASNLVQNYKKRKFTDMED