wanglab/gogpt-training-data huggingface dataset:
Protein: Adenylate kinase isoenzyme 6 homolog (AK6) (EC 2.7.4.3) (Dual activity adenylate kinase/ATPase) (AK/ATPase) (Q9FJI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Preferred phosphate donor and acceptor are ATP and AMP, respectively. Has also ATPase activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03173}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03173, ECO:0000269|PubMed:23121860}.
Interaction partners:
- Adenylosuccinate lyase
- Adenylosuccinate lyase
- RNA-binding NOB1-like protein
- Adenosine kinase 2
- Adenosine kinase 1
- Alkaline-phosphatase-like family protein
- At1g72880
- At5g66005
- 5'-nucleotidase
- AMP deaminase
Sequence:
MARRNRGVTRRERPNLLITGTPGTGKSTTASALAEATNLRYICIGDLVKEKEFYHGWDNELECHFINEDSVIDELDDAMIEGGNIVDYHGCDFFPQRWFDRVVVLRTENSVLYDRLTNRGYSGTKLSNNLQCEMYQVLLEEAHDSYDEEIVTELQSNTIEDISNNVSTLTDWINAWQP
Protein: Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (A0A024QZ33)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD
Protein: Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (3-ketoacyl-CoA reductase) (3-ketoreductase) (KAR) (Microsomal beta-keto-reductase) (Q6FRM0)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03107}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03107}.
Interaction partners:
- Candida glabrata strain CBS138 chromosome K complete sequence
- Elongation of fatty acids protein
- Very-long-chain
- Elongation of fatty acids protein
- Acyl-CoA desaturase
- Candida glabrata strain CBS138 chromosome M complete sequence
- Imidazole glycerol phosphate synthase hisHF
- Acyl-coenzyme A oxidase
Sequence:
MTFVRELEVASQNSRAFNVTLWFIFIFGLLKLVPFALRFLSMVFDLFVLPPVNYAKYGCKAGDYAVVTGASDGIGKEFASQLASKGFNLVLISRTESKLVALKDELEGKFNIKAKILAIDISADSKDNYNKIYSLCDDLPISILVNNVGQSHSIPVPFLATEEEEMRNIITINNTATLMITQIIAPIIIRTVKKHRESGDKKLKSQRGLILTMGSFGGLIPTPLLATYSGSKAFLQNWSSSLAGELAADNVDVELVLSYLVTSAMSKVRRTSMMIPNPRTFVKSTLRNIGRRCGAQDRYGTITPFWSHAIYHFVIEELFGVYARVVNEINYKFHKSIRIRAVRKAVREAKQN
Protein: Rap guanine nucleotide exchange factor (GEF) 1 (F6ZDE5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLASYAASSFSVSYCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
Protein: Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) (ADP-glucose pyrophosphorylase) (ADPGlc PPase) (ADP-glucose synthase) (P9WN43)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the biosynthesis of ADP-glucose building block required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
Interaction partners:
- Alpha-maltose-1-phosphate synthase
- Glycogen phosphorylase
- 1,4-alpha-glucan branching enzyme GlgB
- 4-alpha-glucanotransferase
- UTP--glucose-1-phosphate uridylyltransferase
- Malto-oligosyltrehalose trehalohydrolase
- Glycogen operon protein GlgX homolog
- Glycogen synthase
- Trehalose-6-phosphate synthase
- Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
Sequence:
MREVPHVLGIVLAGGEGKRLYPLTADRAKPAVPFGGAYRLIDFVLSNLVNARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRLGPRWYTGSADAIYQSLNLIYDEDPDYIVVFGADHVYRMDPEQMVRFHIDSGAGATVAGIRVPRENATAFGCIDADDSGRIRSFVEKPLEPPGTPDDPDTTFVSMGNYIFTTKVLIDAIRADADDDHSDHDMGGDIVPRLVADGMAAVYDFSDNEVPGATDRDRAYWRDVGTLDAFYDAHMDLVSVHPVFNLYNKRWPIRGESENLAPAKFVNGGSAQESVVGAGSIISAASVRNSVLSSNVVVDDGAIVEGSVIMPGTRVGRGAVVRHAILDKNVVVGPGEMVGVDLEKDRERFAISAGGVVAVGKGVWI
Protein: Zinc finger FYVE domain-containing protein 26 (F1Q533)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MHPFGREEETSRRELFGFFRRCLQRGEWELAAACVSQLGEARAEDPHSPRDIVKAIVTHPYPLRWETVGSPHRLAWYWLQVLERPTEIKVSVSVKRELEFLLLLEELEDIPQSVLKELHEAFLYSEEVKGKAPGDSASPLSAALLSCLRSLLTRQQPRLCHSLISFLSNGDPSRDHTLQDAFIQHLTEQVKVPAKDRNREWVEQVCSVLALAPWGSDRSGAQLEPLWEGLWAAREGLMTEERILGCLLRPQSQALLMAYSSTALRLLKDKLLAEAPHTQVDLPDLERVMLGLCCHKDKRLAWKAIYFECLSSGKHFLEQVLLTGLDLIKREEFSKLETLLHSEFQPLSRLLLLLGWMHCQSLESAKTLLTVLHHRQPQSNDSALSDLACTLSCQLGVLEWCTQNNPGISHDALLSHLHMLDHHSALYVLHCLTPLAKFEEHKVLELLQRTGDPSQVDSPSSSVQRNITLFRGFCAMKYALYAISVNARTHAHTGSLDCEPLHELQTEAAQEDETAEGCSNLFQHYLSECQLYLEAVPALFRLELLENIFSLLFLSDSDFTQQTSTATETQPYTNTETSKPKSTKEVNTAEHFLKAENEGERMDELNQINPQLGHLTSGCRGFLVDLNVMEGILRLVREGLEGVCGVGQEDGRALGADVELAESLGCSVTAETFSARLQRLSKYTAEAQWRLQIVTSNHGNGNDGLYLPSPLPSPALPLKRQGSGSSGTSSRRRRKHHRHRSERHVSSERQNGEVSTSTSDGGVCVSVVCRGTETCPCGGSHSWLVPAMLSPPESLLIACIRRGNYIEAQQVIAMYGLENSECAGELVFMDRYREVLIELAQVEQKIESQSLSTSSSSSEGLGTLGATPAGRTRMGSSSRLTLKSIGSAAAAGMAFYSISDVADRLMSTPSRPIPCLEDSYWLSQCTIDSPDFVRPLVEELSPAAMAAFDLSCCQCQLWKTSRQLLETAERRLSSFLEARGVRVDPKVPHANGIRGFPSVLQQISKILNKTSTNKGMSKTDCNGEENAVCSPFGCSAQEVLLSCHSTLTEESITIQQNLNQRLEVTLQTLSSATNTSVDSLVGSNLLTALAEQAALKQSELDCHPVRTAMKQLLQYLDQLCPLVPDGAPDRPDYIRSFFDYVNVLASVLVRSLGSEDQSTVVKLGNPLLLLLQSPAQLLSHLLFDRQVSPDRVLSLLQQERLRLSVQQVVVQRCCETLPLWDSRAVNFSQRVSGLNGGAFCPASIASILQQYAQDCSPSLDLSDPTTTSDPSSESEVSVEDVSAASTSLSTSPPSPSSSSPSSSFLLTPSALSFLKSRSPLVAALACLSASRGGVTRVTSSGWSGLPSYFRGSGRKEAVLDGEQISREGEALLKNFPILRMYLRTMAEPVLGVSLEADEGLGVALCGKPVVGMLFSGLQGNAAQAMAAEAFQQALNNGDLNRALDLLELYAQPCSQEGALRDKLLAFTALQESSSAEQLFRVRDWELRGRVVLQGLDRWPLQQCLDLLHFCLSDQNTKDPLREQLQQRKQELDMYQRMLRLQPSLPWETWQELREESTKNPESVFSQMLEAREFELCAQWVQLYSVSDQSGMQLQTEHLLYLLEHNHTEEAFQLLEALSDSMGLEVSERALDRRPGLAACHFLSDYLTLHFQSQMTPARRRHIHALHLGSKVLLTLPEASRQDYFSLLSDPLLMLEQMLMNLKVDWAAVAITTLRSLLLAQDAGITTQHIDTLLADYARKALDFPYAPREWSRSDSVISLQDAFLQCPAQESCPSSPSHTPPPSTGGTPMQTPSSERRPSGKKIRPLATPFTPPEKTPDRKDWIPDHKQHICMVCQRERFTMFNRRHHCRRCGRLVCHSCSSKKMAVAGFDEPVRVCDQCYNFFHTDSDEELEQGEAGSPSSIDEVLNGVLSLPEVSRKQYRLSPNPAENQQLKSEFYYEQAPSASLCVAILTLHSDHAACGQQLIDHCRSLSRKLTNPEVDARLLTDVMRQLLFSAKLMFVNAGCTQEPALCDSYISKVDVLKILVTANYKYIPSLDDIQETAAVTRLRNQLLELEYYQLAVEVSTKSALDPNGVWQAWAMASLKAGNLSGAREKFVRCLKAPVDRNQLNHGPRLLQEIIQHLESTVKLTLSQTMDEDILASLRELEEALSDSAPPEGTESKVQRCNFHQECLFYLFTYGTHLSLISFYLRHDCLKDALTYLQNKGCSDDVFLEGIFQPCLERGRLGALQGLLENLDPTLETWGRYLLSACQLLQRRGHYHSLYQLQQFMMDHIRAAMTCIRFFSHGAQSYLQLGEQQRWLIRAKEHLRTYLQEQQSRRKSHSSSFRKKMSSTDVSRHIHTIELQLEVTRFLHRCESSPSKTAVGSTYTGNSAPPTLFGNSPMKVDVACKVMLGGKNIEEGFGIAYRVIQDFQLEALAVYIRVGQRLVRQRQYSSVRQLHKCVGESGTASKHDCDAIVLSCVSVADKSPADAKELETLILECKNPENKIKAYLQCSKLRAAYLQAVKLKLVKATPLIQEVMRAAESSGDSVMHDICRQWLSEHQEPSSKQR
Protein: Signal transducer and activator of transcription 1 (P42225)
Organism: Mus musculus (Mouse)
Function: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11294897}. Nucleus {ECO:0000269|PubMed:11294897}. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus. Translocates into the nucleus in response to interferon-beta stimulation. {ECO:0000250|UniProtKB:P42224}.
Interaction partners:
- Signal transducer and activator of transcription 2
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK2
- E3 SUMO-protein ligase PIAS1
- Interferon regulatory factor 9
- Signal transducer and activator of transcription 3
- Interferon gamma receptor 1
- Histone lysine acetyltransferase CREBBP
- Interferon regulatory factor 1
- Interferon alpha/beta receptor 1
Sequence:
MSQWFELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIYNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEQEIKTLEELQDEYDFKCKTSQNREGEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQTWFTIVAETLQQIRQQLKKLEELEQKFTYEPDPITKNKQVLSDRTFLLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKSRLLVKLQESNLLTKVKCHFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAELRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKNDLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEMSRIVGPEFDSMMSTV
Protein: LD13015p (Zydeco, isoform D) (Zydeco, isoform H) (Zydeco, isoform I) (Q5LJX7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPLTRDSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQKCAKGGVKQARSRSRSSNCSIHTKNSNEKEPELVENRICQNMANIQLNGGLNKEQAKATSTSGAGTTAISITTSTMTTTLSTTHSAGGGGGAVGLCSGPGAIVQMAPLDDAEAESHVAVAAADEGRKEEGYSLLSYPKDKSCFAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVFFPIQPGQNYVAINSAGLEYSAITLLSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASLIELNVFFRVNLPTCGRS
Protein: Defensin-like protein 209 (Q2V3K2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Defensin-like protein 218
- Pollen receptor-like kinase 6
- Defensin-like protein 223
Sequence:
MKITILFLTLLVLSSSCTSIITKTMNSKETIYLDNPAVSPSIDQNLVDIHLGHSFVQGVMSFCYDCGKACFRRGKNLARCQKFVCRCTISKLR
Protein: Fes protein (B2GV16)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKSQYRTLTRDSAQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHYHQFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSAPDVPPCVTFDVSLLEEGEQLEPGDLQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQCEEQNTHPRERVQLLGKRQVLQEAMQGLQVALCNQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTPGHTLTSVPGLRSRSEMGEGHPPWRSLKATSLESSAPSSPSLLRCSSFQRCRSPSTSSCGTMGLSLGQR
Protein: Dynein axonemal assembly factor 3 (F1Q7Z7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.
Subcellular location: Cytoplasm {ECO:0000250}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q32NQ7}.
Interaction partners:
- Dynein axonemal assembly factor 4.
- Dynein axonemal assembly factor 11
- Zinc finger MYND domain-containing protein 10
- Dynein axonemal assembly factor 19
- Dynein axonemal assembly factor 1
- Sperm-associated antigen 1A
- Dynein, axonemal, intermediate chain 1, paralog 1.
- Axonemal dynein light intermediate polypeptide 1
- Cilia- and flagella-associated protein 298
- PIH1 domain containing 3
Sequence:
MSAGRTFEGAGCVTWWGFGPARDLLNSDTHKVRLQEELNVLLVGSGDPRHILKTITGLTHSDTLHVWVIENSMEVIARQLLLLYISLLPPDKMSVHKKTEVFLEVFGNLEIRKETEESVKKAAAQLSISITYSLSSDSLSHSCLDTSLLKFKERDELVRIFKLWERPPSAPASVSKVWDARVRQHLGSRYDSRQGAFDWDLNMKLHQRGCGVINKHQYAKWRETGVTFEMREGLYQTANQSLLSTRVFNHRGNGVALRGYWGDIVSSPYLSFGIETENKELLKTQNNHYVKTAQDISEVNLLELFECLAARGRSPLNEDPPNTSSSCCQSTESRKTEENSQSDPSASQTQPVEHSPTQELDLLNVNGVKVSFLSPDSLSKLPLKSKYRNLFNTIFCSASMVHQLDSALREIAAPDAALVIELATFLLDLSKEQVSGFAVKVKEIAEESGFTPAHDQNSDKYAVFTQKNN
Protein: Replication protein A 70 kDa DNA-binding subunit B (OsRPA70b) (Replication factor A protein 1B) (Replication protein A 1B) (Q10Q08)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Replication protein A 32 kDa subunit B
- Replication protein A 32 kDa subunit A
- Replication protein A 32 kDa subunit C
- Replication protein A 70 kDa DNA-binding subunit C
- Replication protein A 70 kDa DNA-binding subunit A
- Os01g0660500 protein
- ATP-dependent DNA helicase
- Replication protein A 14 kDa subunit
- DNA polymerase delta catalytic subunit
- DNA replication ATP-dependent helicase/nuclease
Sequence:
MDSDAAPSVTPGAVAFVLENASPDAATGVPVPEIVLQVVDLKPIGTRFTFLASDGKDKIKTMLLTQLAPEVRSGNIQNLGVIRVLDYTCNTIGEKQEKVLIITKLEVVFKALDSEIKCEAEKQEEKPAILLSPKEESVVLSKPTNAPPLPPVVLKPKQEVKSASQIVNEQRGNAAPAARLAMTRRVHPLISLNPYQGNWIIKVRVTSKGNLRTYKNARGEGCVFNVELTDVDGTQIQATMFNEAAKKFYPMFELGKVYYISKGSLRVANKQFKTVHNDYEMTLNENAVVEEAEGETFIPQIQYNFVKIDQLGPYVGGRELVDVIGVVQSVSPTLSVRRKIDNETIPKRDIVVADDSSKTVTISLWNDLATTTGQELLDMVDSAPIIAIKSLKVSDFQGLSLSTVGRSTIVVNPDLPEAEQLRAWYDSEGKGTSMASIGSDMGASRVGGARSMYSDRVFLSHITSDPNLGQDKPVFFSLNAYISLIKPDQTMWYRACKTCNKKVTEAIGSGYWCEGCQKNDAECSLRYIMVIKVSDPTGEAWLSLFNDQAERIVGCSADELDRIRKEEGDDSYLLKLKEATWVPHLFRVSVTQNEYMNEKRQRITVRSEAPVDHAAEAKYMLEEIAKLTGC
Protein: adenylate cyclase (EC 4.6.1.1) (Q9NJA1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MYKKTAYAPRKCYLDYTDERLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFSEQKKLIYYESLTAIVVLVAVPGILSINFFESFVLRHRWIMVFSSILSAYIVVLVDIFQILVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIEIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREEFKKMPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDVINSKLYHYDIVTDNCFNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIVFFQYSFIFEHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYLDSVANHELYYENYKMVSVMFAMLINFQMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFVGIDDNLKFLPSNVKKNNMSKRFSILSSLVPVHSRSTTSSEYI
Protein: Ras-related protein R-Ras (EC 3.6.5.-) (p23) (P10833)
Organism: Mus musculus (Mouse)
Function: Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
Interaction partners:
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Ral guanine nucleotide dissociation stimulator
- Plexin-B1
- Plexin-B2
- Neurofibromin
- RalA-binding protein 1
- Son of sevenless homolog 1
- Leucine-rich repeat protein SHOC-2
Sequence:
MSSGAASGTGRGRPRGGGPGPRDPPPGETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICTVDGIPARLDILDTAGQEEFGAMREQYMRAGNGFLLVFAINDRQSFNEVGKLFTQILRVKDRDDFPIVLVGNKADLENQRQVLRSEASSFSASHHMTYFEASAKLRLNVDEAFEQLVRAVRKYQEQELPPSPPSAPRKKDGGCPCVLL
Protein: Aquaporin-3 (AQP-3) (31.4 kDa water channel protein) (Aquaglyceroporin-3) (P47862)
Organism: Rattus norvegicus (Rat)
Function: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:7517548, ECO:0000269|PubMed:7526388}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}. Basolateral cell membrane {ECO:0000269|PubMed:7517548}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}.
Interaction partners:
- Aquaporin-11
- Aquaporin
- Aquaporin-8
- Lens fiber major intrinsic protein
- Vasopressin V2 receptor
- Aquaporin-4
- Aquaporin-2
- Aquaporin-5
- Aquaporin-1
- Glycerol kinase
Sequence:
MGRQKELMNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWAFAGNELVVSGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSEVFTTGQNWWWVPIVSPLLGSIGGVFVYQLMIGCHLEQPPPSTEAENVKLAHMKHKEQI
Protein: DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (Q2T9T3)
Organism: Bos taurus (Bovine)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P19388}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P19388}.
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC10
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase II subunit RPB7
Sequence:
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDGLDQTLEEFKAQFGGKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ
Protein: Protein CUSTOS (A9C3N6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Essential for Spemann-Mangold organizer formation and subsequent anterior head development in the embryo. Inhibits canonical Wnt signaling pathway by antagonizing nuclear import of beta-catenin (ctnnb1) during embryogenesis.
Subcellular location: Nucleus envelope {ECO:0000250|UniProtKB:P0DPK0}.
Interaction partners:
Sequence:
MSESSSEDENTARLKEAVWSFKPEDVKINGKENNGRQSHRADVSKHEHDGNELGTTPEFRSHVAKKLGTYLDGCISEVCSDTVEPAQSENREDEEGFRLFSSSTPGKWMEQSPPPPPKRRPVPSSSDSDSEMEMRFREAAVSLSDILGPVAQNLSEKTEEKSTKEETEDTVTKMKKKKKRKTSSEESQDKVNHQTEKQSNVEGNQEQTTAGERLKKKKKKKKKKRKKLEKDIKKDE
Protein: NAD kinase 2, mitochondrial (EC 2.7.1.23) (NAD kinase domain-containing protein 1, mitochondrial) (B7Z8V7)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|PIRNR:PIRNR017565}.
Interaction partners:
Sequence:
MLLAASKVLDRLKPVIGVNTDPERSEGHLCLPVRYTHSFPEALQKFYRGEFRWLWRQRIRLYLEGTGINPVPVDLHEQQLSLNQHNRALNIERAHDERSEASGPQLLPVRALNEVFIGESLSSRMSYSWAVAVDNLRRSIPTLKGLASYYEISVDDGPWEKQKSSGLNLCTGTGSKAWSFNINRVATQAVEDVLNIAKRQGNLSLPLNRELVEKVTNEYNESLLYSPEEPKILFSIREPIANRVFSSSRQRCFSSKVCVRSRCWDACMVVDGGTSFEFNDGAIASMMINKEDELRTVLLEQ
Protein: MIP17104p (Tau, isoform E) (D3DMW4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MADVLEKSSLLDAVPPLGDPHPPLPHQQLQQEAAAAAAANAAPPAPPQQQQPPPHQLQQQQPQQQQLQQKPANARANQDQKESSGNQTNSVLE
Protein: Homeobox protein DBX1 (Developing brain homeobox protein 1) (P52950)
Organism: Mus musculus (Mouse)
Function: Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MMFPGLLAPPAGYPSLLRPTPTLTLPQSLQSAFSGHSSFLVEDLIRISRPPTYLSRSIPAASLSPPSQEAPAALADSGTSDLGSPGSGSRRGSSPQTALSPASEPTFLKFGVNAILSSAPRRETSPALLQSPPPKTFAFPYFEGSFQPFIRSSYFPASSSVVPIPGTFSWPLAARGKPRRGMLRRAVFSDVQRKALEKTFQKQKYISKPDRKKLASKLGLKDSQVKIWFQNRRMKWRNSKERELLSSGGCREQTLPTKLNPHPDLSDVGQKGPGDEEEDNPGARLAYHAPADPRHLLEGPLPASPAHSSSPGKPSDFSDSDEDEEGEEDEEITVS
Protein: Coenzyme Q8B (M0R340)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWLKVGGLLRGTGGQLGQTVGWPCGALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIRRAREARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEMAKKSMPGGRLQ