Protein: Protein unc-80 (Uncoordinated protein 80) (Q9XV66)
Organism: Caenorhabditis elegans
Function: Probable component of the nca-1 sodium channel complex, a cation channel that regulates neuronal activity by transmitting depolarization signals to synapses. Regulates the transition from slow to rapid forms of locomotion. Required for localization of nca-1 along axons and in non-synaptic regions. Contributes to endocytosis defects in synaptojanin mutants. Involved in the control of anasthetic response to halothane.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncoordinated protein 79
- Four domain-type voltage-gated ion channel alpha-1 subunit
- NCA Localization Factor
- Sodium leak channel NALCN
- Rx_N domain-containing protein
- Innexin unc-7
- Potassium channel domain-containing protein
Sequence:
MHVRYLQHEHTGTVQLLLMPLSTAASFKSAKWTEEEGEEECDSVPLPIQTFLWRQTNPFLGDKIGKLHEASCVTFERVVVQNILHGLSPSLSNALASVSRWKLVRAALPHVIQCCGSLLLANVGEKKLPTSLQKILYILHWMLIDSSSECIENASTKDDRSVCQSRTQGLFNISSIQLFIYLIAPLADVISEEEVVDNIRLESGLKVWQAIWQFRQPDVWCFSAPVKQRRDELPQITFARRQNPAQLDTQGIYLGKDENTVRRPSIVPPPKPPRTDVTVLNEKRKLEEEKMKMKEDYVAIEIEAPSLKPNDLLIDMSQGVRNKEFERTSSIVRSVSEYKTNLCGQKEKLATVSKSRTSDAFDSSPTSDSSANMLEEVEGIKFSENENCSLSAVFFSSDQAPLVNLSDICSGFSIEEPHDSTQSSVEVPQHPVLESSMFLSTTSSASDVPPFVLTRASTAEDTTSSCSQQTVIPLAMPVTTETTTLPVTLPKSALTKTTNENRRTDHQRMPSTQKSVSGSTDDELDEGSFSDPTIASYLDVAVIRALLITHWQEKGVYWALSYIHNRLIEIKAYMIIRKSTRQRSNSLPSGERKLSVAPEQLTNPVWDDLKIENKPEEGRSHLHVAFNDTERRKSSDNCLAPHPTTNSRRSSLNTLSRRGINRSNPSLSNSVEVLSIRDDAEDDVSNISSKSIEKENTKLNAVFYPEALGSTNFIEKDGKISATVIVQTVNQVMDRCTGVRQCELALNIADVLLGTPLEQTETFFVQLNIMVFKIYLCLGCPHGCNEGVKSPHGDFLRAKAKAILAGLERVQPDKFKNILNDYVDNYGTQQVIDLLHSITSFCRSELTALDGRRASESRVPSYRNTFNEKDKGIEGRIINATYKTLITKISVISAELSLPENMSLQQDVRLLVNFVQEHHGNPFRRVGLSALKDATCKNPTTSDFHTKEDQTGGSPGAQSQKQSNDQASLRRGLFKKKNEKSGGTTTGNDDSEGDSSPSTPRTVSSMDDGVSPLASTSYYKKKSAPKLHFAFGLLKSVKPDMDEEISDNENEEGTSNEEAGLPQRRPLRQSSKQVKARLPIDSKGGMRLWGTYVPPPNYIDAKGIFDGARRFAFLLETARPGTFPDAPLIAAIMHLKSPVLARASLLLECANLVSRCNRGQWPEWIRSSHHRTFSLGGALANRGTPSATRRMHSLQRQAGRYFYQWGVQIGEHISKLLELSENKSKKTLQMEDTIEDFFDDGIVNNQNGEKCPIALQFIAVLLLQEITAFLRETFKTIPRSKNSKPQTGNSGWDKLLSHRRWSILSNTFNAQQTGSVNSITEINSSIHLNDKERRISFSATEEDSPRGSKDAIDEINAVDKKGSIHMQVVRPPSLSARLFSRQSTHEESGGSAQGSTKSTTYVPETGRRIATGRQRLLKRGSPMATGTQPSLESSHKRKSFRNRKQSKQAHLEEEEKSDGGSLTSQQSPIVQRMRAASMRQSSNFLALFHHAIPEFLDAGATHILSARESLKPTDDGLQSPVESVHPVIIPHSNHGSAHSQQPVVLKSSMDDEEQHMLSNLPWIKVLIKFSNSFDLECNHVGVCSAKCFQRVHRQCFRMIESLSTLYGMERNVSTRADKRNLLADNWQAKQQALRKQTETNSARASIHARQSTAVPRRESAMVGQPEFASKAIKMMLMEKMQQEKEKEKEKEKEEKDALKKQSVEQDHSSTDTEEDAQLPEKNKPMLTYLRSLVLQLVHSPISSVLKCCLLLSVEQHKQMIEVCWKMLIHEDPHVVASAASMFIVASVKKSEESLLIIKTALDSQDPQVRTSGIQRFYTLWRNRFHAWLKMEDGAQASFKVPPPGIDFTLPSPAIGQSQLPVVDPPWMPHLKTKIEELSLKEEEHATSQTIMTMTRTRRKQKQEMVKRAVREAEERQSEQRQLFRLRSSAIVSLAAYEPALFHHQQEQTEESDNSHQHARHVMPVAQPLFPSALLSVVPQIIELLDDPQVDNNGVSVGDVAKKVIWTCIVEDPSLFLRHFLEKLTNRDRQVLISEYAPTPAYEALMSQLRKLVLRFHPLPSQAAHSLLNYLFGFVMHYVRAQCEGSEKAIGMALSICWLLSPNIHGLYFKDLKQTLKKEQCDQALMITANVPSAKKIIVHGLDSTSGGIPSQFPVHEDTQFHQILNDSLEFFNIDEDDLNCFYLTDTKTGVIHLPAAYVRDYYFFHRSFYPQLTLVKLSPEVAEKKMKETAFHQKFIECGKVLLTHNILKYSPQHVIAQRVFFLHDEFTHLPSFPRKSLETCFGMYFGPGGEQLKAMESMHKFVWAKMMSDMFEKMENAFMFADLHLFINVINGIMIMHCEDVLILRRCAATYISISIHFNTLFASQGFFLIMPTLLRCYSQRQTNKVFCGVVEFICRQFYTLHRKPFLLQMCGAIANIIDNSSNDFEINPMRVKAKYWFNLIKKMEEITDEDPLDILGLVPYEKPLKALDLCYRDDPNTFCALTDAMASCICVCAFSPESKRSHHMLLIMQAMLPHMMKRLEEETLQSGNSPAAVKHEISQWITMAVEMKALINSCEQLVRGPTRAFDLVNSVSERGKSFVADSPQFFDPPTTNEDENSRPYHLKEKRSTAVAWEAAEVEEQQKETYRRPRDTLLQLIAAYIEMASVRLKELTKLGANLEHAKIPDVLDHKCYVKLGEVALALLKVAPYDLSTTTCHGLQKYFQIILPVTDWSIESNRSALNIILRRLDKTLSKIAKRQSFRKRAIWIALSSWINGICDTLNAFPYIAHLHPLRTITQLCLRMMVGDPCVEDSAASTALHPTTVLHPTPPPQTFANAVLRLTTILMQALGQFAFSLDFVTSTEGMGVSSERLEAVLCHVLIPLFLRIPNNPKEQSIFQAKDLSQCLTVMQNAISPPLVKQQAPPLISTSTLTTTFIRGAQDVTGRQGSVSVTDRGHSATVSTHRIVRESICQAIYLGLKVLMLTFGKLLAPMWPRVARIVKDLLAKKPGAPTSMAFVDFLLHSNLPISLFILPMIQNKMKQKPGTDQEAAWQTEILEKLDAKSHNIVPPSILLVKCYQELQQLKEELTMKPIEMTRSYTPTMADPHSDSSAASTAPRGASSRQSIDRRTSVHMKKVLPTMKEDIPEDPEDSEDVIDSNSTGQVTSRISKSPSIPLNKTHQSSRTRSVSGFGMWRSVRRKSRHVSSAEESSEERGSVELHDVGHHSALHEPNRTPNRRSTEALVLPLHESIDTNRHRFVSFSTPKKTHEVSEDVFQITEQHQLV