wanglab/gogpt-training-data huggingface dataset:
Protein: LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] (O00370)
Organism: Homo sapiens (Human)
Function: Has reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Also has endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome. Conformational properties of the target DNA sequence rather than specific nucleotides are key determinants of the ORF2p capacity for sequence-specific DNA recognition. Unlike related endonucleases, does not bend the DNA helix but causes compression near the cleavage site.
Interaction partners:
Sequence:
MTGSNSHITILTLNVNGLNSPIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLKIKGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQQEELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGDFNTPLSILDRSTRQKVNKDTQELNSALHQTDLIDIYRTLHPKSTEYTFFSAPHHTYSKIDHIVGSKALLSKCKRTEIITNYLSDHSAIKLELRIKNLTQSRSTTWKLNNLLLNDYWVHNEMKAEIKMFFETNENKDTTYQNLWDAFKAVCRGKFIALNAYKRKQERSKIDTLTSQLKELEKQEQTHSKASRRQEITKIRAELKEIETQKTLQKINESRSWFFERINKIDRPLARLIKKKREKNQIDTIKNDKGDITTDPTEIQTTIREYYKHLYANKLENLEEMDTFLDTYTLPRLNQEEVESLNRPITGSEIVAIINSLPTKKSPGPDGFTAEFYQRYKEELVPFLLKLFQSIEKEGILPNSFYEASIILIPKPGRDTTKKENFRPISLMNIDAKILNKILANRIQQHIKKLIHHDQVGFIPGMQGWFNIRKSINVIQHINRAKDKNHVIISIDAEKAFDKIQQPFMLKTLNKLGIDGMYLKIIRAIYDKPTANIILNGQKLEAFPLKTGTRQGCPLSPLLFNIVLEVLARAIRQEKEIKGIQLGKEEVKLSLFADDMIVYLENPIVSAQNLLKLISNFSKVSGYKINVQKSQAFLYNNNRQTESQIMGELPFTIASKRIKYLGIQLTRDVKDLFKENYKPLLKEIKEDTNKWKNIPCSWVGRINIVKMAILPKVIYRFNAIPIKLPMTFFTELEKTTLKFIWNQKRARIAKSILSQKNKAGGITLPDFKLYYKATVTKTAWYWYQNRDIDQWNRTEPSEIMPHIYNYLIFDKPEKNKQWGKDSLLNKWCWENWLAICRKLKLDPFLTPYTKINSRWIKDLNVKPKTIKTLEENLGITIQDIGVGKDFMSKTPKAMATKDKIDKWDLIKLKSFCTAKETTIRVNRQPTTWEKIFATYSSDKGLISRIYNELKQIYKKKTNNPIKKWAKDMNRHFSKEDIYAAKKHMKKCSSSLAIREMQIKTTMRYHLTPVRMAIIKKSGNNRCWRGCGEIGTLVHCWWDCKLVQPLWKSVWRFLRDLELEIPFDPAIPLLGIYPKDYKSCCYKDTCTRMFIAALFTIAKTWNQPNCPTMIDWIKKMWHIYTMEYYAAIKNDEFISFVGTWMKLETIILSKLSQEQKTKHRIFSLIGGN
Protein: Splicing factor 1 (F1LM37)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367126}.
Interaction partners:
Sequence:
MEPRHNGTEDSDSRHAYGYPPWPDSGTRKSLYRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHTLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPASNPPPPSLMSTTQSRPPWMNSGPSENRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQRSLPAAAMARAMRVRTFRAHW
Protein: Cd6 molecule (Cd6 protein) (Q5FVU4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MWLFLGIAGLLTAVLSGLPPPAPSDQHRNGSIPNMSSDPEEQLGIRLVNGSSRCSGFVQVLLESWEPVCAGHWNRAATEAACNALGCGDLGNFTHLAPPTSERPPGATSRNTSSSRNTTWAGAPTVRCHGANWQLCKVEDYECSSDRRLVWVTCAENQAVRLVDGGSRCAGRVEMLQHGEWGTVCDDTWDLDDANVVCKQLKCGWAVKALAGLHFTPGQGPIHRDQVNCSGTEAYLWDCPGRPGDQYCGHKEDAGVVCSEHQSWRLTGGVDSCEGQVEVYFRGVWSTVCDSEWYPSEAKVLCQSLGCGSEVDRPKGLPHSLAGRMYYSCKGEELTLSTCSWRFNNSNLCSQSLAARVVCSGSQRHPNLSTSEVPSRVPVTIESSVPVSVKDKDSQNLTLLIPCIVLGILLLVSLIFIVFLLLKAKGQYALPTSVNHQQLSTANPAGINNYHPVPITIAKEDSQRHRVTEEEAQQNRFRMPPLEEGLEELHVSNIPAADPRPCVVDAPSLGSQYHTRNNSDSSTSSEEGYCNDPSSKPPPWNSQVFSEKSPLTEQPPNLELAGSQAMFSGNRVSFQAPNPVSNLPRRGTDPNPELLAV
Protein: LD14115p (Transforming acidic coiled-coil protein, isoform I) (Q9VN51)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MEFDDAENGLGMGFGGRGVLREINKNDGGIKLSPLAVKPSPKPTSMDQQKAMAAALGHQTAVPGGLKPEDDLVPKFGGLPEFDETQIPELAPLSTDMDTQLKSNHSDSDVFVECLSLHSERYTGDRSELEAYSSALNDVLEQQLSMTSVSTLGAEFNDPLAVSQHNNVSYEAMDVDDLNETMEMLKDVLNAEDRHLMQTHILSVTQSKPENNFVHYHPNQEQNRVELDQLAKHSKPNSDAKESESLVESVLSEESGTQSFEPKLTLSALDSTKDLAKHQEEMQTNTKDIFQKEKHHPVSSAQVKDAQNPKEPEKALNLKEASSELSTKSAKSLEYPNQEKQFSVAVESMERPCTAISLEQNASPAMEATEDRTVEELDQMDVDESMKVDDATVLNSCRQEQINAHSPVSSKFFLKLCVQNDTDCQDNKMDQKTAGKESALKMTEIELPVESVPSASLSPPTPALQAKIIELSLSPPIPTHRPKTAEELEFLALRELPLPDGVSTAGKVECKQLSHGLVPIVAVLPTPLYLDLKGNTTTASLPEPTSPSFPIKEPAEKQSHFPRSPRAQLEQKDMPYLEEAVVERSSHRKQSDFGVIAKSPIVFELTQPSPEKQHLNETLPMSEISPTSSNMTFDSGSITEDKSQKGTENIEPSSTLAVSLGSVDDKQRRTFSVVQPTKEEEEAKSRRTFCMENENPRRTFCMQQNASPAVEATEDTGADEVMDVDISMRADEVAVMKSHQQTWKERQAPISNSPPIPTHQRLNRPPEAISPVSPLGNGTVVLEEQTLSAKEQATLSASDEKDDVFLEHFGAISPVSDDMFKTSSASNNQAKFRVNADEETGGKGASAMIRKRSGTAGEQEEIFDAEFHDGVNNQNLILNSSDFDYLYTKGSNSVPIDRSSLLLKFDPLLGAPVPVNHPNQQEQALQNILGSNQHQNRLLSPTLEEHETSDGNQSFGVISSAKDTAKKWDFKPPVDRTKKHVKMSVDVIDNDCNKTFDNSNTNTEDKTHNYNDMDELEKKIKNEVTRSEDIEKKLKEGELREEALIKRITEKDKTNAKLNGVIEAYEKAIAELISEKEQQAQLHERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQLEIANKKLDTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICEELIYGKGQGGSS
Protein: LRR receptor-like serine/threonine-protein kinase IOS1 (EC 2.7.11.-) (Protein IMPAIRED OOMYCETE SUSCEPTIBILITY 1) (Q9C8I6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates negatively the abscisic acid (ABA) signaling pathway. Required for full susceptibility to filamentous (hemi)biotrophic oomycetes (e.g. H.arabidopsidis and P.parasitica) and fungal (e.g. E.cruciferarum) pathogens, probably by triggering the repression of ABA-sensitive COLD REGULATED and RESISTANCE TO DESICCATION genes during infection, but independently of immune responses. Involved in BAK1-dependent and BAK1-independent microbe-associated molecular patterns (MAMPs)-triggered immunity (PTI) leading to defense responses, including callose deposition and MAPK cascade activation, toward pathogenic bacteria (e.g. P.syringae). Required for chitin-mediated PTI.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27317676}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Chitin elicitor receptor kinase 1
- Receptor-like kinase
Sequence:
MAFSSCFLLVLLQIFSALLLCLAQDQSGFISLDCGSPRETSFREKTTNITYISDANFINTGVGGSIKQGYRTQFQQQTWNLRSFPQGIRNCYTLNLTIGDEYLIRANFLHGGYDDKPSTQFELYLGPNLWSTVTTTNETEASIFEMIHILTTDRLQICLVKTGNATPFISALELRKLMNTTYLTRQGSLQTFIRADVGATVNQGYRYGIDVFDRVWTPYNFGNWSQISTNQSVNINNDYQPPEIAMVTASVPTDPDAAMNISLVGVERTVQFYVFMHFAEIQELKSNDTREFNIMYNNKHIYGPFRPLNFTTSSVFTPTEVVADANGQYIFSLQRTGNSTLPPLLNAMEIYSVNLLPQQETDRKEVDAMMNIKSAYGVNKIDWEGDPCVPLDYKWSGVNCTYVDNETPKIISLDLSTSGLTGEILEFISDLTSLEVLDLSNNSLTGSVPEFLANMETLKLINLSGNELNGSIPATLLDKERRGSITLSIEGNTGLCSSTSCATTKKKKKNTVIAPVAASLVSVFLIGAGIVTFLILKRKKRTKLGLNPNSGTGTTPLHSRSHHGFEPPVIAKNRKLTYIDVVKITNNFERVLGRGGFGVVYYGVLNNEPVAVKMLTESTALGYKQFKAEVELLLRVHHKDLTCLVGYCEEGDKMSLIYEFMANGDLKEHLSGKRGPSILTWEGRLRIAAESAQGLEYLHNGCKPQIVHRDIKTTNILLNEKFQAKLADFGLSRSFPLGTETHVSTIVAGTPGYLDPEYYRTNWLTEKSDVFSFGVVLLELVTNQPVIDMKREKSHIAEWVGLMLSRGDINSIVDPKLQGDFDPNTIWKVVETAMTCLNPSSSRRPTMTQVVMDLKECLNMEMARNMGSRMTDSTNDSSIELSMNFTTELNPGAR
Protein: Family of serine hydrolases 1 (EC 3.1.-.-) (P38777)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Serine hydrolase of unknown specificity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MTVQIPKLLFLHGFLQNGKVFSEKSSGIRKLLKKANVQCDYIDAPVLLEKKDLPFEMDDEKWQATLDADVNRAWFYHSEISHELDISEGLKSVVDHIKANGPYDGIVGFSQGAALSSIITNKISELVPDHPQFKVSVVISGYSFTEPDPEHPGELRITEKFRDSFAVKPDMKTKMIFIYGASDQAVPSVRSKYLYDIYLKAQNGNKEKVLAYEHPGGHMVPNKKDIIRPIVEQITSSLQEASE
Protein: TL antigen (Q62323)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
FGSLFRAYEQHGYDGRDYIALNEDVKTWTAADMAAEITRSKWEQAGYTELRRTYLEGPCKDSLLRYLENRKKTQECTDPPKTHVTHHPRPEGYVTLRCWALGFYPAHITLTWQLNGEELIQDMELVETRPAGDGTFQKWAAVVVPSGEEQKYTCHVYHEGLPEPLTLRWEPPQSSMPTRTIVRALLGAMVILGVMRGSGMMWMRKNKGGNRDDNTAACQNEREHLSLSAGDESDALGVEAGLKELPTAPPLVP
Protein: Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) (Q06826)
Organism: Rattus norvegicus (Rat)
Function: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (By similarity). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Bone morphogenetic protein receptor type-2
- Bone morphogenetic protein receptor type-1A
- Serine/threonine-protein kinase receptor
- Chordin
- Noggin
- Activin receptor type-2A
- Activin receptor type-1
- Activin receptor type-2B
- Bone morphogenetic protein 6
- Bone morphogenetic protein 2
Sequence:
MIPGNRMLMVVLLCQVLLGGATDASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEEQSQGTGLEYPERPASRANTVRSFHHEEHLENIPGTSESSAFRFFFNLSSIPENEVISSAELRLFREQVDQGPDWEQGFHRINIYEVMKPPAEMVPGHLITRLLDTRLVRHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHTLTRRRAKRSPKHHPQRSRKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Protein: Eva-1 homolog A, regulator of programmed cell death (B8ZZF5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MKGSKSFVLQKMFSCSKNPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY
Protein: Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase) (P15651)
Organism: Rattus norvegicus (Rat)
Function: Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q3ZBF6}.
Interaction partners:
- Enoyl-CoA hydratase, mitochondrial
- Trifunctional enzyme subunit alpha, mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- Trifunctional enzyme subunit beta, mitochondrial
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Peroxisomal bifunctional enzyme
- Ethylmalonyl-CoA decarboxylase
- Acetyl-CoA acetyltransferase, mitochondrial
- Acyl-coenzyme A synthetase ACSM3, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 1
Sequence:
MAAALLARAGGSLGRALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
Protein: Protein lin-54 homolog (CXC domain-containing protein 1) (Q6MZP7)
Organism: Homo sapiens (Human)
Function: Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Myb-related protein B
- Histone-binding protein RBBP4
- Protein lin-52 homolog
- Protein lin-9 homolog
- Protein lin-37 homolog
- Transcription factor E2F4
- Retinoblastoma-like protein 2
- Myb-related protein A
- Forkhead box protein M1
- Transcription factor Dp-2
Sequence:
MEVVPAEVNSLLPEEIMDTGITLVDDDSIEAVIVSSPIPMETELEEIVNINSTGDSTATPISTEPITVYSNHTNQVAVNTTITKADSNTTVKPAFPSGLQKLGAQTPVTISANQIILNKVSQTSDLKLGNQTLKPDGQKLILTTLGKSGSPIVLALPHSQLPQAQKVTTQAQSGDAKLPPQQIKVVTIGGRPEVKPVIGVSALTPGSQLINTTTQPSVLQTQQLKTVQIAKKPRTPTSGPVITKLIFAKPINSKAVTGQTTQVSPPVIAGRVLSQSTPGTPSKTITISESGVIGSTLNSTTQTPNKIAISPLKSPNKAVKSTVQTITVGGVSTSQFKTIIPLATAPNVQQIQVPGSKFHYVRLVTATSASSSTQPVSQNPSTNTQPLQQAKPVVVNTTPVRMSVPIVSAQAVKQVVPKPINPTSQIVTTSQPQQRLIMPATPLPQIQPNLTNLPPGTVLAPAPGTGNVGYAVLPAQYVTQLQQSSYVSIASNSTFTGTSGIQTQARLPFNGIIPSESASRPRKPCNCTKSLCLKLYCDCFANGEFCNNCNCTNCYNNLEHENERQKAIKACLDRNPEAFKPKIGKGKEGESDRRHSKGCNCKRSGCLKNYCECYEAKIMCSSICKCIGCKNFEESPERKTLMHLADAAEVRVQQQTAAKTKLSSQISDLLTRPTPALNSGGGKLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAERMILEEFGRCLMSVINSAGKAKSDPCAMNC
Protein: Rap GTPase activating protein 1, isoform H (A8DYW8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ras-related protein Rap1
- 14-3-3 protein zeta
Sequence:
MSSYRTLVDHGHPIIVGSSEISLAPSSAASSPKPLHRMIKYWRNSSGKIPGLRKSESFAEYRRHSSNSATISGGSGGRSSTSSARQLQYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGGGSGSGSVTHSPERLRGATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVPQPHSPHDSHAHPHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQLLSNGHHYQSQSSVSSNSSIVSAIPASQRLLEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRTGTMHELLPVSCLLPQPSPAKMAHTLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAGSPTPETPKAESGSGGNAGSRFIDTVKKALIMRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQTPNLNTCSRTASKSSSKSKSSNESTSSSPDITSRQANNNNTNSIGGHLPQNGTGGGVVAAAVSAAQNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYIDSDTGLESMSSAEATTKACSLCLDGVQSTIMGSSPSNETIVKIENLRQEVTRLKCDKLDLLRQNVTCQRDIKRLRERELSLQGDLSAAGREILRLRDLLKEYMPDTASAPLSISPI
Protein: Uncharacterized protein (Q389C3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTALVVQRFRECQNLLDSVVTNLCAIENFTSQRSTVEEAAWRLRSSTSVRDAAVPLCCTDPLGMLAVFPESAVELIIAQHDDDMAALLRSLNSTQQMWGKKLQQAKEALQSGESGKAKDANVADKQRDVSQVICTRSFIAVLSQMHGWLRALILALRADLANPPRAVKLSEFLSAHDPPLKSDITPVVIVSLEAALGQLPDRVRREWELCTSQHMVDEAWVMLLS
Protein: Helix-loop-helix DNA-binding domain containing protein (Q2QMM8)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MEMTSYNDVDAGDMFAAADYYSAGAGGDLFDMVWPGRRRREEDNTSGCLPLSPPPPPELAVDDQLLAGGDGGGGKPVAVAVAEDDDSGERWTEDQVPTDEGICVMEKRRCKINENLKTLQQLVPVCDKSNNQASTLDKTIRYMKSLQQHAQAMSVGCSMKTAEAAGVTCPFLPPPPSSALLVIVEEGPTRPWDATARSTSAAATSFDHHHHGALIEKLLQVVQPYMLSLKTSVRENNAMVMQKPNFYHS
Protein: Kelch domain-containing protein 1 (Q8N7A1)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL5(KLHDC1) complex mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:16964437, ECO:0000269|PubMed:32200094}.
Interaction partners:
- Cullin-5
- Elongin-B
- E3 ubiquitin-protein ligase RBX1
- RING-box protein 2
- Elongin-C
- Ankyrin repeat and SOCS box protein 4
- Ankyrin repeat domain-containing protein 9
- Cyclic AMP-responsive element-binding protein 3
Sequence:
MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRLWHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQTQPYSLLRSCLDCIGKNSIMLESQISLLPPKLLQQVLKKITFWAAANHREEQRVQKEETENKYQWISSN
Protein: Tight junction protein 1 (G5E9E7)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
Interaction partners:
Sequence:
MERNTFSMDCHSKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQVYRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
Protein: T. brucei spp.-specific protein (Q38D15)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWFIAPTPFALKHRCPAIVLGGFSLTAAVCCEVVALKQRRYIVKILKKGNSGAFSCSCILIGTLRWWPMALLVRGRYHEVTKKILKRQKGEKGKIFCHCATADAMILHESPHHYCKWAARGGSEDWDYSNSFVVVCAVLLENIATNEREGECHLTFHAATSTHHDYMLVALRGKVVKAKVSFRFKEV
Protein: SEC24 homolog C, COPII coat complex component (A0A286YCC8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MNVNQSAPPVPPYGQNQPIYPGYHQSSYGGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAPPSSGAPPASAAQVPCGQTTYGQFGQGDIQNGPSSTAQMQRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAGMQISGAVAQAPPPSGLGYGPPTSLAS
Protein: Flagellin B (Q56572)
Organism: Vibrio anguillarum (Listonella anguillarum)
Function: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaB is not essential for flagellar synthesis and motility.
Subcellular location: Secreted. Bacterial flagellum.
Interaction partners:
- Flagellar secretion chaperone FliS
- Flagellar filament capping protein FliD
- Protein FlaG
- Flagellum-specific ATP synthase
- Flagellar motor switch protein FliG
- Flagellar motor switch protein FliN
- Flagellar basal-body rod protein FlgC
- Flagellar hook-associated protein FlgK
- Flagellar biosynthesis protein FlgE
- Flagellar biosynthesis protein FlhB
Sequence:
MAINVSTNVSAMTAQRYLNNAADGTQKSMERLSSGYKINSARDDAAGLQISNRLTSQSRGLDMAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSANGSNSSSERQAIQEEVSALNDELNRIAETTSFGGNKLLNGSFGNKSFQIGADSGEAVMLSMSDMRSDTKAMGGKSYVATNGKAPDWSVTNATDLTLSYTDKQGEAREVTINAKAGDDLEEVATYINGQNGDIKASVGDEGKLQLFAANQKVSSDVTIGGGLGTEIGFAAGKDVTVKDINVTTVGGSQEAVALIDGALKAVDSQRASLGAFQNRFGHAISNLDNINENVNASRSRIKDTDYARETTQMTKSQILQQASTSVLAQAKQSPSAALSLLG
Protein: Pi3K21B, isoform C (Pi3K21B, isoform D) (M9PAY7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MILQMGFDKWQQLYETVSNQPHSNEALWLLKDAKRRNAEEMLKGAPSGTFLIRARDAGHYALSIACKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPVLYWKNNPLQVQMIQLQEEMDLEYEQAATLRPPPMMGSSAPIPTSRSREHDVVDGTGSLEAEAAPASISPSNFSTSQ
Protein: Cytospin-B (Sperm antigen with calponin homology and coiled-coil domains 1) (Q5SXY1)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 4]: Membrane {ECO:0000250|UniProtKB:Q5M775}; Lipid-anchor {ECO:0000250|UniProtKB:Q5M775}.
Interaction partners:
Sequence:
MRSAAKPWSPVAKAGSHGPDRTRPLPGTPSGMKSSKSSTSLAFESRLSKLKRASSEDTLNKPGSASSGVARLKKTSTSGAISELTESRLRSNTGTIPTTKRTGIPAPRELSVTISRERSVPRGPSSSKKLGSSPTSSCNPTPTKHLRTTPAKPKQEHEGAEKAVLESQVRELLAEAKTKDSEINRLRSELKKCKERWALSTEDANASDPSAEGTASPESDAQPLIRTLEEKNKTFQKELADLEEENRALKEKLTYLEQSPNSEGAASHTGDSSCPTSITHESSFGSPVGNELSSETDEYRRTTHGSALRTSGSSSSDVTKASLSPDASDFEHITADTPSRPLSATSNPFKSSKGSPTGSSPNNASELSLASLTEKIQKMEENQHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLINLLQERVKNEEPSAQGGKVLELEQKCTDILEKSRFEREKLLNIQQQLTCSLRKVEEENQGAIDMIKHLKEENEKLNGFLEHERCNNSVMAKTLEECRVTLEGLKMENGSLKALLEADKQKAIEASSTVGQTAENFEVQEMLKVARAEKDQLQLSCTELRQELLKANGEIKHVSSLLAKMEKDYSYLKEVCDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELEGSVIKLEEQKSDLERQLKTLTKQIKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRRLLEEEEKNARLQKELGDIQGHSRWVTGRATLLPVNEEPEPSEADAAGRWRGVYVNRTSPAPSDSATTVKSLIKSFDLGHSGGTGQSISVHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSMKPASKGTSQRLDLPDLPLSDLLKGRAEDRKSDPYLRKSPSLESLSRPPSLGFGNTRLLSASTGGLKPSKLSVERRDPLAALAREYGGSKRNALLKWCQKKTEGYANIDITNFSSSWSDGLALCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAQSVGINPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET
Protein: Zinc finger BED domain-containing protein 3 (Axin-interacting protein) (Q96IU2)
Organism: Homo sapiens (Human)
Function: Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin (By similarity). Involved in transcription activation of Wnt target gene expression (By similarity). Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network (By similarity). Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9D0L1}. Membrane {ECO:0000250|UniProtKB:Q9D0L1}. Secreted {ECO:0000269|PubMed:24283382}.
Interaction partners:
- Axin-1
- Oocyte-expressed protein homolog
- NACHT, LRR and PYD domains-containing protein 5
- AN1-type zinc finger protein 6
- Inactive protein-arginine deiminase type-6
Sequence:
MRSGEPACTMDQARGLDDAAARGGQCPGLGPAPTPTPPGRLGAPYSEAWGYFHLAPGRPGHPSGHWATCRLCGEQVGRGPGFHAGTSALWRHLRSAHRRELESSGAGSSPPAAPCPPPPGPAAAPEGDWARLLEQMGALAVRGSRRERELERRELAVEQGERALERRRRALQEEERAAAQARRELQAEREALQARLRDVSRREGALGWAPAAPPPLKDDPEGDRDGCVITKVLL