wanglab/gogpt-training-data huggingface dataset:
Protein: Metastasis associated 1-like, isoform B (Q9VNF7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQPALDEERTSPTQTSGGGGSATGNSGSNSSGTSNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTLLNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELESLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHKHEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIEYYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGSTDLSSNGKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAASTPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGIAISSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQAEIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPKPPKAPDGSLVYDRVPNKSPDVVAVPADKELTIIPTQATSTIRKRAHEDQQLNGTEVTIVPSGPPAKRPNKDPMPSHCPSPEQFAAMMAASGQPLSRHHLNGKQKIAQMARGGNGRKQVISWMDAPDDVYFRANDTHKKTRKILSAVDLRRAARKPWRTLPIKPAAPEPSSRPIESQIVILD
Protein: Subtilisin-like serine protease (EC 3.4.21.62) (Tk-SP) (Q5JIZ5)
Organism: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Function: Serine protease with a broad substrate specificity.
Interaction partners:
- Predicted zinc-dependent protease
Sequence:
MKKFGAVVLALFLVGLMAGSVLAAPQKPAVRNVSQQKNYGLLTPGLFKKVQRMSWDQEVSTIIMFDNQADKEKAVEILDFLGAKIKYNYHIIPALAVKIKVKDLLIIAGLMDTGYFGNAQLSGVQFIQEDYVVKVAVETEGLDESAAQVMATNMWNLGYDGSGITIGIIDTGIDASHPDLQGKVIGWVDFVNGKTTPYDDNGHGTHVASIAAGTGAASNGKYKGMAPGAKLVGIKVLNGQGSGSISDIINGVDWAVQNKDKYGIKVINLSLGSSQSSDGTDSLSQAVNNAWDAGLVVVVAAGNSGPNKYTVGSPAAASKVITVGAVDKYDVITDFSSRGPTADNRLKPEVVAPGNWIIAARASGTSMGQPINDYYTAAPGTSMATPHVAGIAALLLQAHPSWTPDKVKTALIETADIVKPDEIADIAYGAGRVNAYKAAYYDNYAKLTFTGYVSNKGSQSHQFTISGAGFVTATLYWDNSGSDLDLYLYDPNGNQVDYSYTAYYGFEKVGYYNPTAGTWTIKVVSYSGSANYQVDVVSDGSLGQPSGGGSEPSPSPSPEPTVDEKTFTGTVHDYYDKSDTFTMTVNSGATKITGDLYFDTSYHDLDLYLYDPNQNLVDRSESSNSYEHVEYNNPAPGTWYFLVYAYDTYGYADYQLDAKVYYG
Protein: Kinetochore protein SPC24 homolog (AtSPC24) (Protein MERISTEM UNSTRUCTURED) (Q67XT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity to ensure proper cell division. Required for the maintenance of plant architecture.
Subcellular location: Chromosome, centromere {ECO:0000269|PubMed:29356153}. Note=Colocalizes with CENH3 at the centromere. {ECO:0000269|PubMed:29356153}.
Interaction partners:
- Kinetochore protein SPC25 homolog
- Protein unc-13 homolog
- Kinetochore protein NUF2 homolog
- Kinetochore protein NDC80 homolog
- Vacuolar protein sorting-associated protein 53 A
- Exocyst complex component SEC6
- ATPase 1, plasma membrane-type
- Conserved oligomeric Golgi complex subunit 4
- Putative syntaxin-24
- Gls protein
Sequence:
MGNASENFDIEDLMSYGDDLINLLNVKNGFDIISQSSEQFKALNFACHEDFNQIQGSIEDCKTKLYACKKKTEEAYSDIAAEDEIERLQKELDEEMEREFKLKDELRLVADELKDLNAQLSSIDEHKQSTKRKVRDDLRAEKKLSMYASVTNVIPDIDDPSKISGYMVDREKRLIEKFQFETNKMTAYETCNSIWSIINKQ
Protein: Hydrogenase-4 component C (EC 1.-.-.-) (P77858)
Organism: Escherichia coli (strain K12)
Function: Possible component of hydrogenase 4.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:9278503}; Multi-pass membrane protein.
Interaction partners:
- Hydrogenase-4 component E
- Hydrogenase-4 component B
- Hydrogenase-4 component F
- Hydrogenase-4 component G
- Hydrogenase-4 component D
- Formate hydrogenlyase subunit 5
- Hydrogenase-4 component I
- Formate hydrogenlyase subunit 3
- Hydrogenase-4 component H
- Formate hydrogenlyase subunit 7
Sequence:
MRQTLCDGYLVIFALAQAVILLMLTPLFTGISRQIRARMHSRRGPGIWQDYRDIHKLFKRQEVAPTSSGLMFRLMPWVLISSMLVLAMALPLFITVSPFAGGGDLITLIYLLALFRFFFALSGLDTGSPFAGVGASRELTLGILVEPMLILSLLVLALIAGSTHIEMISNTLAMGWNSPLTTVLALLACGFACFIEMGKIPFDVAEAEQELQEGPLTEYSGAGLALAKWGLGLKQVVMASLFVALFLPFGRAQELSLACLLTSLVVTLLKVLLIFVLASIAENTLARGRFLLIHHVTWLGFSLAALAWVFWLTGL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A1D8PI35)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- non-specific serine/threonine protein kinase
- Alpha-factor pheromone receptor
- Ste3p
- Casein kinase II subunit alpha
Sequence:
MNFGTSHSSSSKNSHNNNVVGLHYKIGKKIGEGSFGVIFEGVNILNNAQVAIKFEPRKCEAPQLRDEYRAYKQLQGSKGIPNAYYFGQEGVHNILVIDLLGPSLEDLFDWCGRRFSIKTVIQVAIQMIRLVEQVHQQNLIYRDIKPDNFLIGKPDTPEANQIFFVDFGMAKQYRDPRTKQHIPYREKKALSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGALPWQGLKAPTNKQKYEKIGMKKQTTSINELCYGFPIQFAQYLTYVRNLKFDETPDYQYLVGLMEKASISAGIELDGHFDWMDLNGGKGWDAALNKKANLHGYGNPYPHPSQGQRRXAATTAGTIQTTTIITKISTIQFTPSTITWEFSFKR
Protein: Inner kinetochore subunit fta2 (CENP-P homolog) (Constitutive centromere-associated network protein fta2) (Sim4 complex subunit fta2) (Sim4-mal2-associated protein 2) (Q9US26)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere.
Subcellular location: Nucleus. Chromosome, centromere, kinetochore.
Interaction partners:
- Inner kinetochore subunit fta7
- Inner kinetochore subunit fta3
- Inner kinetochore subunit mal2
- Inner kinetochore subunit mis6
- Inner kinetochore subunit fta4
- Inner kinetochore subunit fta6
- Kinetochore protein mis14
- Inner kinetochore subunit mis17
- Inner kinetochore subunit cnl2
- Inner kinetochore subunit fta1
Sequence:
MSGRRYSQISQQEGSSSSDDSDSQQKKTKRTVAHRSPNTTLNGMPRVDSRARPNENSGQSKSSNGRVDTDRKMDLLRKRSNLVHQTLLLEKEVRVRRNAINQRDDSFLSGFIKSLLEIDSSVVIYNTENPDNPKTKQVMPSAEPKKHVKLNSSISSIRFTQHEFEAESEKIIHHSLKGDIEYLPSFKFLLEIKVRTIDYALLFITYKIPHFARKELSSFSDSAIQCLDIVALLRAFSLFAHHYSYRCNTWFYLSKHMKKVASANMDAQCFYVQNSFYKITILYEIKFDDLGFVQPNYCISYILKNQNEKIVSITSKLLNQLDKRFSEFVSLFGFREGSLLLLQALFKPHLG
Protein: Leucine-rich repeat-containing G-protein coupled receptor 4 (B0BLW3)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May play a role in regulating the circadian rhythms of plasma lipids (By similarity). Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9BXB1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXB1}.
Interaction partners:
- Uncharacterized protein.
- Uncharacterized protein.
- R-spondin-2
- E3 ubiquitin-protein ligase ZNRF3
- E3 ubiquitin-protein ligase RNF43
- Leucine-rich repeat-containing G-protein coupled receptor 5
- DEAH-box helicase 36
- gamma-butyrobetaine dioxygenase
- Hemopexin
Sequence:
MGCPGWPLALFALLLASCSGGPSGVSSPAPCPAPCACDLDGGADCSGKGLVTVPDGLSVFTHSLDLSMNNITKLPEGAFKGFPYLEELRLAGNDLSIIHPMALSGLKELKVLTLQNNQLKTVPSESLKGLVSLQSLRLDANHIVTVPEDSFEGLVQLRHLWLDDNSLTEVPIRPLSNLPSLQALTLALNKISHIPDYAFSNLSSLVVLHLHNNKIRTLGPHCFHGLDNLEALDLNYNNLIDFPDSIRSLPNLKELGFHSNSITIIPDGAFVKNPLLRTIHLYDNPLSFVGNSAFQNLSDLHFLIIRGASNVQWFPNLTGTNNLESLTLTGTKIRSIPIKFCQEQKMLRTLDLSYNEISALVGFEGCSSLEEVYLQNNQIQEVQNETFQGLAALRMLDLSRNRIHTIHKEAFVTLKALTNLDLSFNDLTAFPTAGLHGLNQLKLTGNPNFKETLTAKDLIKLSSVSVPYAYQCCAFSACNSYMTTTVEEDRLRAQRLLLDHDRAAMDPDYMGTEDDKEHVQALIQCNPATGPFKPCEYLLGSWMIRLTVWFIFLLALIFNVIVIVTMFASCSQLTSSKLFIGLIAVSNLFMGVYTGTLTVLDTISWGQFAEFGIWWETGNGCKVAGFLAIFSSESAIFFLMLAAIERSLSAKDIIKKEKHQHLRKFQVASLLAVLLAAAAGCLPLFHIGEFSSSPLCLPFPTGETPSLGFTVTLVLLNSLAFLIMVITYTKLYCTIEKEDLSENAESSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAIYISPEIMKSVTLIFLPLPACLNPVLYVFFNPKFKEDWKLLRWRLTKRSGSVAVATNSQRGCVTQDFYYDFGMYSHLQGGNFAVCDYCESVLLKNPPPCKHLIKSHSCPTLAVVPCQRPDNYWSEFGTQSAHSDCADEEDSFVSDSSDQVQVCGRACFYQSRGLPLVRYAYNIPRMKD
Protein: N-acyl-aliphatic-L-amino acid amidohydrolase (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) (V9HWA0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPALPSDS
Protein: Importin subunit beta-1 (Importin-95) (Karyopherin subunit beta-1) (Karyopherin-95) (Q06142)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Importin beta subunit that functions in nuclear protein import through association with the importin alpha subunit, which binds to the classical nuclear localization signal (cNLS) in cargo substrates. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by importin beta through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binds to importin beta and the three components separate, leading to release of the cargo. Importin alpha and beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin beta. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of histones H2A and H2B. Mediates the nuclear import of transcription factor GCN4.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:9321403}. Nucleus {ECO:0000269|PubMed:9321403}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}.
Interaction partners:
- GTP-binding nuclear protein GSP1/CNR1
- Nucleoporin NUP1
- Nucleoporin NUP116/NSP116
- Importin subunit alpha
- Nucleoporin NUP2
- Nucleoporin NUP100/NSP100
- Nucleoporin NSP1
- Nucleoporin NUP60
- Protein NAM8
- U1 small nuclear ribonucleoprotein A
Sequence:
MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLFSQATKDTARWAREQQKRQLSL
Protein: GABA(A) receptor associated protein (GABA(A) receptor-associated protein a) (Q6PSS4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- NBR1 autophagy cargo receptor a
- Ubiquitin-like-conjugating enzyme ATG3
- Ubiquitin-like protein ATG12
- Autophagy protein 5
- Cysteine protease ATG4B
- NBR1 autophagy cargo receptor b
- Ubiquitin-like modifier-activating enzyme ATG7
- Cysteine protease
- FUN14 domain-containing protein 1
- ATG16 autophagy-related 16-like 1
Sequence:
MKFMYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGLLYQEHHEEDFFLYIAYSDESVYGDVLKDV
Protein: Uncharacterized transporter YfdV (P0AA49)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Formyl-CoA:oxalate CoA-transferase
- Acetyl-CoA:oxalate CoA-transferase
- Oxalyl-CoA decarboxylase
- Protein YfdX
- Probable multidrug resistance protein EmrY
- NADP-dependent malic enzyme
- HTH-type transcriptional regulator YdeO
- Probable multidrug resistance protein EmrK
- Inner membrane protein YcfT
Sequence:
MLTFFIGDLLPIIVIMLLGYFSGRRETFSEDQARAFNKLVLNYALPAALFVSITRANREMIFADTRLTLVSLVVIVGCFFFSWFGCYKFFKRTHAEAAVCALIAGSPTIGFLGFAVLDPIYGDSVSTGLVVAIISIIVNAITIPIGLYLLNPSSGADGKKNSNLSALISAAKEPVVWAPVLATILVLVGVKIPAAWDPTFNLIAKANSGVAVFAAGLTLAAHKFEFSAEIAYNTFLKLILMPLALLLVGMACHLNSEHLQMMVLAGALPPAFSGIIIASRFNVYTRTGTASLAVSVLGFVVTAPLWIYVSRLVS
Protein: Peroxiredoxin-2D (EC 1.11.1.25) (Glutaredoxin-dependent peroxiredoxin) (Peroxiredoxin IID) (Thioredoxin peroxidase 2D) (O22711)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (By similarity). May be involved in intracellular redox signaling (Probable).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:12913160}.
Interaction partners:
- Peroxiredoxin Q, chloroplastic
- Protein disulfide-isomerase 5-1
- 2-Cys peroxiredoxin BAS1-like, chloroplastic
- Zinc finger A20 and AN1 domain-containing stress-associated protein 10
- 2-Cys peroxiredoxin BAS1, chloroplastic
- Glutaredoxin-C3
- Monothiol glutaredoxin-S2
Sequence:
MAPITVGDVVPDGTISFFDENDQLQTVSVHSIAAGKKVILFGVPGAFTPTCSMSHVPGFIGKAEELKSKGIDEIICFSVNDPFVMKAWGKTYQENKHVKFVADGSGEYTHLLGLELDLKDKGLGIRSRRFALLLDNLKVTVANVENGGEFTVSSAEDILKAL
Protein: Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F) (Q6P9J9)
Organism: Mus musculus (Mouse)
Function: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30785399}; Multi-pass membrane protein {ECO:0000269|PubMed:30785399}. Note=Shows an intracellular localization. {ECO:0000250|UniProtKB:Q4KMQ2}.
Interaction partners:
- Phospholipid scramblase
- Phospholipid scramblase
- XK-related protein 8
Sequence:
MQMMTRKVLLNMELEEDDDEDGDIVLENFDQTIVCPTFGSLENQQDFRTPEFEEFNGKPDSLFFTDGQRRIDFILVYEDESKKENNKKGTNEKQKRKRQAYESNLICHGLQLEATRSVSDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKTRSPFGNLNWFTKVLRVNESVIKPEQEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILSRVKYQVMNNVNKFGINRLVSSGIYKAAFPLHDCRFNYESEDISCPSERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEAQCNHVVINEITQEEERIPFTTCGKCIRVTLCASAVFFWILLIIASVIGIIVYRLSVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYLLGKYRSEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWVMNLIGRYKRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNITDFKNTDKENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHIIYSVKFFISYAIPDVSKITKSKIKREKYLTQKLLHESHLKDLTKNMGIIAERIGGTVDNSVRPKLE
Protein: Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10) (P58304)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters. Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). May play a role in specification of V2a interneurons during spinal cord development (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1. Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1 (By similarity). Acts as a negative transcriptional regulator of MITF (By similarity). Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements. Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells (By similarity). Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation (By similarity). May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q61412}.
Interaction partners:
- Homeobox protein SIX3
- Transcription factor ATOH7
- Nucleoredoxin-like protein 1
- Rhodopsin
- POU domain, class 4, transcription factor 2
- Membrane frizzled-related protein
- Recoverin
- POU domain, class 4, transcription factor 1
- Growth/differentiation factor 3
- Homeobox protein SIX6
Sequence:
MTGKAGEALSKPKSETVAKSTSGGAPARCTGFGIQEILGLNKEPPSSHPRAALDGLAPGHLLAARSVLSPAGVGGMGLLGPGGLPGFYTQPTFLEVLSDPQSVHLQPLGRASGPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSAKDGIMDSCAPWLLGMHKKSLEAAAESGRKPEGERQALPKLDKMEQDERGPDAQAAISQEELRENSIAVLRAKAQEHSTKVLGTVSGPDSLARSTEKPEEEEAMDEDRPAERLSPPQLEDMA
Protein: Cilia- and flagella-associated protein 206 (Q6PE87)
Organism: Mus musculus (Mouse)
Function: Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:32376681}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:32376681}.
Interaction partners:
- Radial spoke head protein 4 homolog A
Sequence:
MPPTQAESVIKNIIREIGQECAAHGEIASETVVAFMVKAVVLDPSNGFNMDRTLIKTDVQKLVKLCVARLLDNKNPSLDTIKMQVYFDMNYTSREDFLEEHHRVLESRLGIVSREITDNRASAREELENLYRKIVSYVLLRSGLGSPTDIKIVREATAALQSVFPQAELATFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAILHEAIPTTTQHIDSQLQIAQDQAFRYTAILEKVTNNPLMAKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVEMMIKQLAAQLEQLKMAVKSKTAVPTSQVFPIFVALASLWMSFQDETVLISVLSNLTTNLELFLGTHELLFPEKVMLGLLDGVVVKSDLTRIEEHMEERVELADFRTQEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPAIGILKYKEKYYTFSTRDAAYTFAENPDHYIHLIKEKAKKNAELIQLLELHQQFETLIPYSQMRDVDKHYIKPITKCDNGTQTDTHILPPTTMRTYEWNEWELRRKAIKLANLRQKITHSVQTDLSHMRRDNTSQVYPLKEASTQSKREGSSRVPRPQIFIAGLRGGQSKTTYGVKVNLTRAVDET
Protein: AT4g14420/dl3250c (Elicitor like protein) (HR-like lesion-inducing protein-like protein) (O23298)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g27330
- T29M8.11
- F-box/kelch-repeat protein At3g06240
- Large ribosomal subunit protein uL1c
- Protein STRICTOSIDINE SYNTHASE-LIKE 10
- Membrane protein of ER body 1
- At2g32380
- S-protein homolog 12
- Autophagy-related protein 8b
- At2g15220/F15A23.4
Sequence:
MELASFLGRALFVSVFLLSAWQEFNDFGEDGGRSAKSLKPKFNAFVNHVTTHTGQQLPPVDMKILVAAAIALKGIGGLLFVFGSSLGAYLLLLHQAVATPILYDFYNYDVDRKEFGQLFSKFTQSLALLGGLLFFIGMKNSRKHGRQLRKKAPKAKAN
Protein: REL proto-oncogene, NF-kB subunit (F1M5R1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Nuclear factor NF-kappa-B p105 subunit
- Transcription factor RelB
- Transcription factor p65
- Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a.
- NF-kappa-B inhibitor alpha
- NF-kappa-B inhibitor beta
- NF-kappa-B inhibitor epsilon
- Serine/threonine-protein kinase TBK1
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- TPX2, microtubule nucleation factor
Sequence:
MASSGYNPYVEIIEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQIMNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGPERRPLFFQNLGIRCVKKKEVKEAIILRISAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNFTTALPPIVSNPIYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGIFSQADVHRQVAIVFRTPPYCRAIVEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDAYGNKSKKQKTTLIFQKLLQDCESNLFSHGTVLPETPRSSGVPGQAEPYYSSSGSISNALPHHPSAMPSMVHQPASWSPVTHPTSHPGSTNTLSSFPAGQLSSNSQGVLPFLDGAGMNDLSASNACLFSTDNLARMETPSMSPTDLYSISDVNMLTNRPVSVMTSSTDGMGDTDHPRLVSVNLENPSCNSRLDPRDPRQLHQMSTASMSAAGTSSSSVFVSQSDTFNRPHFSCIDNGLTNEPGLANDAHHPNFAQSSQYSGIDALQSEQLGDSFEYSFFKI
Protein: Uncharacterized protein (Q389G0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSQAGVSGNRTTLATPSNDCNDKEILDIIQQRGAPHLYCYPSVRAHSGVRSCYYAACGRGPTLPPPLRTVLSAAASSFHCIVQGRGVNMTRRTVRAEAEEECIAKQISPSCGAPLVSDSTVSMVDAVLRHLCMVKGTPVFLPGFLSYPYYNLLELFDRWGLHIVGYDVDFVKMRVDENDLRLKARSVGLAGSTHFMGNGAKPNRTGSIQNSPPLLLFIGVGGRPISNIESMTHLVRAEFRAVTIELCPLTAAFLDREDSQKPSARADICVMAMDGAGEFGGALAFTGDPLLADGILQQLHKRPTASSRDHWIALALHIAHLLVSDGKSFKFVLHVLRWCSLLMSRKRGGSASRPHVDHIFQFLLATRAKKPLSGLHTFAEVGESCDEGRGKATATVPPHTSNDLSFSKPHPGVIAWLEEAIARAHQDAMLECFSFWEFVSSLRNDVEVVSAGEPQTPKQCVTCHSNAIFVRVREPKLAARALLGAGFGATPLTPHWWGGRQQKTMDGAKMLVKGYLRRLSPHDIVLLPKCPMCEDLAQHALCVPLYPSMKYTNREKLRSAMQSVFPSSLFRSPSDKFHDHVKDSQETHAYHSTAVSNLIIQCKRSISRGEWSAVFSDAQPLLLRCLFGPIPAYVVSKL
Protein: Syntaxin-2 (Epimorphin) (Q00262)
Organism: Mus musculus (Mouse)
Function: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Subcellular location: Membrane; Single-pass type IV membrane protein.
Interaction partners:
- Synaptosomal-associated protein 23
- Vesicle-associated membrane protein 2
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 8
- Vesicle-associated membrane protein 1
- Syntaxin-binding protein 2
- Alpha-2,8-sialyltransferase 8B
- Synaptosomal-associated protein 25
- Alpha-soluble NSF attachment protein
- Vesicle-associated membrane protein 4
Sequence:
MRDRLPDLTACRTNDDGDTAVVIVEKDHFMDGFFHQVEEIRSSIARIAQHVEDVKKNHSIILSAPNPEGKIKEELEDLDKEIKKTANRIRGKLKSIEQSCDQDENGNRTSVDLRIRRTQHSVLSRKFVDVMTEYNEAQILFRERSKGRIQRQLEITGRTTTDDELEEMLESGKPSIFISDIISDSQITRQALNEIESRHKDIMKLETSIRELHEMFMDMAMFVETQGEMVNNIERNVVNSVDYVEHAKEETKKAIKYQSKARRKKWIIAAVAVAVIAVLALIIGLSVGK