wanglab/gogpt-training-data huggingface dataset:
Protein: Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1) (Q5JS13)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10889189}. Cell membrane {ECO:0000269|PubMed:10889189}. Note=Associates with membranes through the PH domain.
Interaction partners:
- Growth factor receptor-bound protein 2
Sequence:
MYKRNGLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE
Protein: IMD domain-containing protein (Q95Y95)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDPDAEFNLLTTLYQSVVHDMKHTYPGWDALSQKAQKLGTQLRATAQCLSTFTEAMQGVCDNANNLKGASRDVGACVTRVCIKQRAIENRMRSWADALCEELAISLQQRGNYWKSRCHDMDKTAAKHVKKVRSRKQRPDVTAMNEQREICTKVLTEQRTQFSFFIGTLMPVLNAQMNMLDEGAHLRQVVDNLDSTVKHVDTEQLVSSIVSDIAQGPDSAWKQCLAQAGNKWRSSEDGYSCMGSIRDLSTRATTPASNFSSEDGMHTLTGNGLGGTTRSISTSCTRNLPLITGNGNMESSASSVISSSTRYSKPPLQRRNSEKSIGHYSMSSPNTDGSSTYLNLMGNGAGNSSSNTITEMSQYQQQHHQPVIRAVSNGTHSNAPPAYQQYINQRQQNGGSIPRPQNLAFEPFNPTTSIGATPTVYHPATPATTSSGGQPETSPGSSATSASAFLISEACRDIDQLGSDLENYCSVQDPTRYFIHESSPSSGQKNGTPPAATNTMIAAMIQRRASHAGDYQQQQTMSDPGKRASVSTLGSSNMSNYGVLSHQPPLPQSANSMQNQQVRMRTTSASRPPPPARRTSQITAATPTAPSVAEQRMNGSTMGSRQSLDSAGLYDPAHPQQFYQMSSFNRSNNVNGQASATAAAAKFRI
Protein: Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Malonate-semialdehyde dehydrogenase [acylating]) (P52713)
Organism: Caenorhabditis elegans
Function: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q02253}.
Interaction partners:
- Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial
- Probable 4-aminobutyrate aminotransferase, mitochondrial
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Propionyl-CoA carboxylase alpha chain, mitochondrial
- Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
- Enoyl-CoA Hydratase
- Propionyl-CoA carboxylase beta chain, mitochondrial
- Putative aldehyde dehydrogenase family 7 member A1 homolog
- Acetyl-CoA C-acetyltransferase
Sequence:
MLSRLARVQPKCQQLAHFSTSKSAAAAPTVKLWIDGQAVESKTTDFVELTNPATNEVIAMVPNATQAEMQAAVDSAKNAFNTWKNTSPLTRQQCMFKLQALIKRDMKKLAESITIEQGKTLPDAEGDVSRGLQVVEHACSVPSLMMGETLPNVSRDMDTHSYRIPLGVTAGICPFNFPAMIPLWMFPVALATGNTMVIKPSEQDPGAAQLLVELAKEAGVPDGCVNIIHGQHSAVNFICDNPDIKAISFVGGDAAGKHIYERGAKNGKRVQSNMGAKNHGVIMADANKEQTLNQLTAAAFGAAGQRCMALTTAVLVGEARAWLPELVEKAKNLKVNAGWKPDTDIGPLISKQSKARVLRLIESAKKEGAQVPLDGSNITVPGFENGNFVGPTILAGVKPNMTCYREEIFGPVLVVMEAENLNEAIEIINNNPYGNGTAIFTSNGATARKFTNEVDVGQIGINVPIPVPLPMFSFTGSRGSFLGDLNFYGKAGIQFYTQWKTVTQYWNESLTELKPQMSFPQLK
Protein: Vacuolar protein sorting-associated protein 70 (EC 3.4.-.-) (P47161)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in vacuolar protein sorting.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRMIQRERKREKEEGQLKERTVVNMADPDDNEAEATGLQQYSGETTRDDNEESMNDSFTLTSRNRGRSNTISSIVSGYEIMKEHMDKEKFMYLILASLLLYMGFVAAFAPRTSLSRDFRRFHSSRLTNAEVYRIYLNSLQQENRAKEHVYKYAGYMSNGASDSSTFKYTLDEFLDMGYKPKVEKYYPWIGEPVDTNVAPLENGKVVYEASMIEDRVKGDPASHARKRQKGFHQYSKNGSVTARYVFCNYGSISDYKLLLKKNIDIEDKIHIVRSGKILPGLKVKNAELYGASSVIIYTDPFDDGKVTEENGFLHYPYGPARNPSYIRRDSVNYFSDTPGDPTTPGYPSKDSDTEHMSPVGRVPRIPSVPMSARDVQPILERLNGRGFQIGPGSNIKDFGSFTGPSSSIDKVHLHNELTYNIKEMSSVEVSIPGIFTEGEIIIGAHRDSLASSSAGDANSGSAILLEIARGMSKLLKHGWKPLRPIKLISWDGERSGLLGSTDYAEAHAAILRRRALVYLNLDNAISGTNFHCKANPLLQDVIYEAAKLTEFNGHEDWSLFDHWKYTSNATISLLDGLSSYTSFQYHLGVPAAHFQFNANDTSGAVYHSNSVFDSPTWLEKFTNSDYKLHNTMAMFVGLTTLMLSENELARFNTHVYLKKIYNWYIAWHSNLSSAFPQDDEVNSLAKRVLDLLKVATQEDSIQFDQQNGILYKECREALPVWAFYKKIKSYIKLQRSNSKSKQIDQLFITHRGLKDREWMKYSLLAPSKFEGSVGEVLPGLHEGLADIDRNEVIQWLTILLSQFSNVRYLLQ
Protein: Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (Q9V434)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- Glutamyl-tRNA
- Tyrosine--tRNA ligase
- serine--tRNA ligase
- Glycine--tRNA ligase
- Isoleucine--tRNA ligase, cytoplasmic
- Glutamyl-tRNA
- Probable glutamine--tRNA ligase
- Alanine--tRNA ligase, cytoplasmic
- histidine--tRNA ligase
Sequence:
MPADQLAELTLGAIFTSEKKGSDESGDGSESKPFKTILQAMRHAGKEPFPTIYVDTKDPNAAEPYEPAAKSQLKKIQKLFVRESHKNADKLQREAEDAEKRQQNLEDARKVKISEDPSLPVARKIRIYEGTANRDSRVKVYGWVHRLRRQGKSLIFITLRDGTGFLQCVLNDQLCQTYDALTLSTESSVVLFGTLKLVPEGKTAPGGHELNVDYWELIGLAPPGGADAILNEEAQPDVQLDNRHIMIRGENTSKVLKMRSVVTQAFRGHYEARGYNEVTPPTLVQTQVEGGSTLFKLKYFGEEAYLTQSSQLYLETCLPALGDVFTISQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLDRLEDLVCDVVDRVLKSPWGYLVKELNPDFKPPQKPFRRMNYEDAIKWLKENNVTKDDGTFYEFGEDIPEAPERKMTDTINEPIMLCRFPAEIKSFYMQRCKEDQRLTESVDVLLPNVGEIVGGSMRIYDSEELLKGYKREGIDPQPYYWYTDQRVYGTMPHGGYGLGLERFLCWLLNRYHIREVCLYPRFLDRCRP
Protein: Distal antenna-young, isoform A (Distal antenna-young, isoform C) (Q9W2B0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00320}.
Interaction partners:
- lysozyme
- Polypeptide N-acetylgalactosaminyltransferase 8
Sequence:
MERFGIPRGKRPRVQVSLDDKERAIARIRGGETKAGISRELGVPESTVRGWVKRAEQRLARETTSQTGSANYSTILAMTLAKPQVTISTKSSASSVISKSSYSSPPLDLKPLKQPQKRNINGHPVTCTQDPVEDSAATSIPIPVPIPVPLPVPPMVSPDSEQQMSAWLHIFNAGILNFTLIASAAVLQARSRGLADRLPLWQIITDFVDEAERNVNANGGWYLEGQPATGHMSARQRPVRVPTKVHSYRRNLKAPPAHITAEDDEDSYTDADVPH
Protein: Uncharacterized protein, isoform B (Uncharacterized protein, isoform E) (Q7PLP4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEKILAVQSDEYTKLQRCYVELQRKYNENIASSENEESGLSSFLSRLSLTVASLFDKNTYADIYIRSQTRVFPAHKIVLHARSEKWGNDLLSNIQQLDWSDLNEDVVLSLLRWIYTDLIDLQNDGLALDLLKAAHRFGLPSLLGICERALVTSVGVRSCIRFYCVAEEVGASTLLEYCSSIISTHWDDLTTDDFQHMSGPLLFEMLKTKTKHPLHAAVRLLREDVVSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLVDNGMANINAVNMEGFSLLKSALKNGDAFSANFLLDQNCLLDLPSKPSSDTALHIICNYGPDNTPEIMEVVKKILQRQLNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTYDEKCALELSLSMGDHEFLIASILLSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLADFADLDHINFRGLTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLKSALHIAVEANAIDALEAFVELKNKSHDIDFNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDISLFLLEQGADITALTENLDSALDLSIKHDLSEVVDALCRRGIALSINKNGESPLWSALEKGYEDVAKILVRHGIDTDCWDEGPEGCRQTLLHRAIDENKESVAIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGANVNLIDAESKSPLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALDFRNHNAAQRILDRFPTAAEQMDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSRVHDANQSSPLHLAAASQNEMITRNLILAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNNALHIAVRCAQFFIVRELLTESRVNAEATNLKGRNPLHELCRVVEDSTAGLICELFLESMPKYPINIPDMDGNTPLLLSFMRGQSPLCKILVKAGACLGTENKDGINIFNFKLATDQLLHNLLDQLPQESPWAESDYCQHCTNRFTITMRKHHCRHCGRVLCSKCSCNDVPILKFGINKPVRVCTVCFNVLQCGNGSLS
Protein: Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) (P54071)
Organism: Mus musculus (Mouse)
Function: Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:8867815}.
Interaction partners:
- Aconitate hydratase, mitochondrial
- Cytoplasmic aconitate hydratase
- Isocitrate dehydrogenase subunit alpha, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Isocitrate dehydrogenase subunit
- Isocitrate dehydrogenase subunit gamma 1, mitochondrial
- Probable isocitrate dehydrogenase gamma 2, mitochondrial
- 2-oxoglutarate dehydrogenase-like, mitochondrial
- Glutamate dehydrogenase 1, mitochondrial
- Malate dehydrogenase, mitochondrial
Sequence:
MAGYLRAVSSLCRASGSARTWAPAALTVPSWPEQPRRHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ
Protein: Histone acetyltransferase (EC 2.3.1.48) (E7EUP3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361211}.
Interaction partners:
Sequence:
MSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT
Protein: Mitochondrial thiamine pyrophosphate carrier 1 (Q5A2T7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- asparagine--tRNA ligase
- Ccc1p
- Divalent metal ion transporter
- tRNA
- ferroxidase
- RBR-type E3 ubiquitin transferase
- Cysteine desulfurase, mitochondrial
- Iron-sulfur clusters transporter ATM1, mitochondrial
- Iron-sulfur cluster assembly protein
- High-affinity iron permease
Sequence:
MEHQLQFLPKDSVEIDYEALPDDASLAAHLTAGALAGIMEHTVMFPIDSIKTRMQMNLSNSEISRGLLKSLSKISSTEGFYALWKGVSSVVLGAGPAHAIYFSVFESTKTFLVNRLTNSPHSNRIVTDENHPLIASCAGITGTTASDALMTPFDMLKQRMQANAAYQDGKSTSVRLFKLASDIYKAEGLSAFYISYPTTLLTNIPFAALNFGFYEYSSSLLNPSHVYNPYLHCVSGGIAGGIAAALTTPFDCIKTVLQTKGISQNQNFRHVTGFKSAAVALLKQEGAKAFWKGLKPRVIFNIPSTAISWTAYEMCKEVLIRGKGL
Protein: Interleukin-4 (D1YSM1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Interleukin 13 receptor alpha 1
- Interleukin 13 receptor, alpha 2.
- Interleukin 2 receptor gamma common.b
- Interleukin 2 receptor gamma common.a
- Interleukin 13
- Interferon gamma 1.
- Interleukin family protein
- CD4-1 molecule
Sequence:
MRTFLLLVLTLVPVSESKLKIDEILLMEIIQSVNGILNGKGEKMDLDQFIPDIYETGHYSKKTLCQAGMALKGKIPSRSHLQRQLNAYAAYTGTGNCSVSTSGECTMKEFLEKTKACCHYLYSAQRT
Protein: Transcription factor Pur-alpha 1 (Purine-rich single-stranded DNA-binding protein alpha 1) (Q9SKZ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that specifically binds the purine-rich double-stranded telomeric repeated sequence 5'-AAACCCTAA-3' found in promoter telo boxes.
Subcellular location: Nucleus {ECO:0000269|PubMed:19245862}.
Interaction partners:
- E3 ubiquitin-protein ligase XBAT33
- Adenylosuccinate synthetase, chloroplastic
- Transcription factor GTE6
- Transcription factor GTE9
- SWR1 complex subunit 2
- Transcription factor GTE4
Sequence:
MEANSGGGGGAEGGRAVTGGGGGGGGSDVELVSKTLQVEHKLFYFDLKENPRGRYLKISEKTSATRSTIIVPSSGISWFLDLFNYYVNSEEHELFSKELQLDSKVFYFDIGENRRGRFLKVSEASVSRNRSTIIVPAGSSPDEGWAAFRNILAEIHEASGLFVMPNQVKPSDGQEHLVDDVGAGFIPGHGSQQPSSSEHNVDRTIDSPGQEETGMTGVSKVIRADQKRFFFDLGNNNRGHFLRISEVAGSDRSSIILPLSGLKQFHEVIGHFVEITKDKIEGMTGANVRTVDPPQR
Protein: G-protein coupled receptor 62 (G-protein coupled receptor GPCR8) (hGPCR8) (G-protein coupled receptor KPG_005) (Q9BZJ7)
Organism: Homo sapiens (Human)
Function: Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2 in the endosome (PubMed:28827538). {ECO:0000269|PubMed:28827538}.
Interaction partners:
- G-protein coupled estrogen receptor 1
Sequence:
MANSTGLNASEVAGSLGLILAAVVEVGALLGNGALLVVVLRTPGLRDALYLAHLCVVDLLAAASIMPLGLLAAPPPGLGRVRLGPAPCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGSRPPPVLVLTAVWAAAGLLGALSLLGTPPAPPPAPARCSVLAGGLGPFRPLWALLAFALPALLLLGAYGGIFVVARRAALRPPRPARGSRLHSDSLDSRLSILPPLRPRLPGGKAALAPALAVGQFAACWLPYGCACLAPAARAAEAEAAVTWVAYSAFAAHPFLYGLLQRPVRLALGRLSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGGRSPAYQGPPESSLS
Protein: Nervy (Q24037)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMALDGKAIIKEEITDKDAYDAAAAAAAAVAAGRALAVASAAAVQVPPASSSSAGSASSAAAAATNNTTSAAATAAAISRRLKASSSGGDKSSTSSSSSKDSSHTSSSRSERDRERERERERERDRLCRTPPDSPPDSSRSLAPRSPHSPLQLHQRPQRNASVSPVVNGSSSGGGGVGSSGTSPTPTPGSQHAASLAAAAAAAAAAHVEQARLVSKMRKFLGALVQFSQELGQPEVSERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQREILALARATNQSALQYVTNNEQAVMEFAPHGVASAEFGDIFIQLEAPTSNGSSAVFKRRSSDSMMEHGGHNGLQEWSEYMASGGAGYPPPPSKRLTLHPAHSVVAYGEYGVSSAEGLPSAAAFMQRDERDLRMSEAQARHAAPPQRAGNPQPNPNAAAPGAPGAGGEEEWKNIHTMLNCISAMVDKTKRAITILQQRGIEPQHPNSGQEVTPAAMAELRRQTEEKVAEFKRNAEDAVTQVKRQAVIEIQRAVVAAETRAAEIMTQERLRMEKFFMEMSRHSSGERDLDNKSPSMASAQNGSNLQQQCWNCGRKATETCSGCNMARYCSASCQYRDWDSHHQVCGNTRASELSAKHLHSASNLSLRNAMATRSPPTPNSAAHLQAAAAAAAAAAGAREAVSAPVGGPGAGIAVGTGAGSGGQSGGGGGGGGGGGGGAAAAAVAAATPGALVANGLGSK
Protein: Mannose-1-phosphate guanyltransferase (EC 2.7.7.13) (Q7D5T3)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILGTSYKPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLRNDTAMVFNGDVLSGADLAQLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEKTEDPPTDQINAGCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMGTPEDFVRGSADLVRGIAPSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGPGTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIRDGVIGDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV
Protein: Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy-like protein) (RHL) (Q04666)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- FA complementation group G
- E3 ubiquitin-protein ligase FANCL
- Fanconi anemia group F protein
- FA complementation group A
- FA complementation group E
- Fanconi anemia group C protein homolog
- Neurogenin 3
- Transcription factor HES-5
- Fanconi anemia group D2 protein homolog
- FA complementation group I
Sequence:
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPGGPQHAPFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTADSMWRPWRN
Protein: SET domain protein, putative (EC 2.1.1.43) (Q8IBB0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Heterochromatin protein 1
Sequence:
MLNDMNDKKDSIRNRNYKKNKKDEERNIRKYSNDNINVVNNMKDIYNNNNNNINKSVIDCGNNLKRIEGKKVFERNKFGQFIKKSNSPSLKDTNIKSNNNKNMKNTNHNNEENNNNNNTNNTLSNKEKIKVLIDKMKKIQNKKEVNKTLDKPMYIRNFQDEKKVSTHNNAYKLKRNGDPRNYGDIKNGDNIKNGDNNKNGDNIKNGDNIKNGDNIKNGDNIKNGDNIKNGDNIKNGDNIKNGDDQIIGCLKNNREPRSNVENETNEMSNSYGKFTKNRDLKNSDKIKMNDEYRRNNDANISDYNKKNNNNNVNKSNNVVRSSDESLSSDTINKSDCKNKVEENSSRNADESHKKEDGDLINKDKDEKEGENLSVPKESNETYYRISRRERCRNLKKEDNLKIINDEDNSVSHFIKEGRKRSVRERSNLRNYNYINVNNNIKDDDFVDEPNNGSSIIKMNERKKTILRRGARHRRRNPRKRGRRCSSLRNNRNTINSVTKSNYDMSDGDNYEKGRKFLYDNSSNYNELDPLNSKFSNIKISKNFFLKMNDDEDEEDEDGVGDDDKTSKNSSYSFGFNERNIEKKIIILEQKDGIYEINENYLKYDNMKDMEDRKNMEDMKNMEDRKNMEDMKNMEYMKNMEYMKNMEYMKNMEDMKNMEDMKNMEDMKNMEDMKNMEDMKNMEDDNKKDYMNDNLKDDIVIKDNIVIKDDIVMKDNIVMKDNINDSVKDNINEELENNETSCKSSKLNDVTHNNNNICDDNNIVSHSNGEMKEVNIMYPINNEINIKKKRILNNDEILILLNLLRDININRFNIKHVMTSKDCMYEKFMLYNLFSYNITCLKSSLKMMYAYCLFKNLKLFYQIQYKNMNMTEKSIPNYKIKNNLLDTHCIILSMFENYYENVSKQKMPIADFINSFYLNIHNINIGKKKVQPNKNYENIVLPEKDNRKITSMYTNKSLLYSNYMNKDINMENKAYKLNDINMENYRSDHKNNTFIDNDCNNNHKYNNICKNELNSCISNISNDPNNNKNVHTMNKDLYGNIYTEQNAYHVHNYKDMRNEHENNNNIKKKDNIENSIYYDNKMYLGANEKTPCLKDIHMNKNYEQTYDNYDGTNGYNNNNKKKNDNKKNDNNNNDNNNNDNNNNDNQDDNHHDNNKEEYNNQNHLFLNNESRKRKFFTNILPYKNKKKKLPYTINLNNDNKTYHHESINNENHMPLWDYKELENIKNMINDEKDEEDCTPLAHSIKITKNYDNINMDECNVRNENQEYKDNVTNYKVCQDGNFECYDVNESVLVRDIHMEKNNNVEKNNNDEKKNNDEKKNNDEKKNNDEKKNNDEKKNNDEKKNNDEKNNDDNNNIIEKAKENIESIPYDKNCSQDNIQYNMAYKDTSLLLCEQRDMDKGNKKEDDTIKMEDIHFSADMECSPMLKYRKRNYDNKNDDDYVKNDDDYVKDDDGCVKNDDGCIKNDDGYIKNDDGYIKNDDGYIKNDDDYNNNGEYLHGSDNNLSAHKYNSVCRRRRRVDRNKESNEKEKRVYRNDIMELENVDVMLLERIKKNYKMLIRNDNENKKKKKKNNGTVTILEDVDNVYDDNNNNNNDNNIDNNNNNNNNNNNNNNNNNVESHNNNNNERGSTKIEKCRKNKITFFNKYSKLLNNDNVDKKKSKYMLTTESLYNNNFNILDIKVNTHFAHNYHISLFFFCKYTSYNLYLHPLNKNEHIVSYVILNSKNEVLTDNGNSFVLRYLLSFLTNKISSLRKCYANALYNSYLLQIPIRIFRHHNLENKYSPQYGIRYDGIYKIINAFTINDYSTPEYKRDILYVFKRLYVDKCFIPNMNPKILDKQDKAERKKNFIEKNSVSINVMMNKEIIMTLRIPYLKNYKSTTFTNFNHIYKFIKKKCIQKKKAMPWIQSEVSIYEACMQHIKKTEEKKKEHFLNSQKMNNIKTKVNNTNDIYNNENLNSGDDAFKDCIQAINVDKSVQQINDVRFDMNDGNYKMGDIKKECSNVYENMFPAKNNNKIDINKININSNHFSNSSNNNNCDNYKRLGEPNFPYWCLGKYLPFVLVLETLNFEKEIDIYKGIRTKNLKNLKISIIKTEIPINCEMAKRPAHLFIPIKSKEAISAYIELKKPYDNHWNPYEDLSGGKEIFKIPVENVVDESLPPMNFTYVNKTIFFSRLPPYNLLPLCSGCAPHNYNKKEYVDLYINGYCKGIRHKKTNRIYCDGNKNYDINDFNVLAACSGNCLCDPLKCTNKFPEGLHYPIKVVKTKDIGWDIVSCSFIKANSLIMHYVGEITTRKEMISREHEYDKKGYFNYFIETAEVDETYPDDWKIPCIDALFISNVARFLNHSCEPNVNVITIWRGDNYPSVGIFASRDIQPNEPLKYHYGINYKNIKCMCASKKCKGYIG
Protein: Extracellular superoxide dismutase [Cu-Zn] 3 (EC-SOD 3) (EC 1.15.1.1) (Q54RQ1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxyde radicals into hydrogen peroxyde and oxygen.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}.
Interaction partners:
- Intron-encoded DNA endonuclease ai2a
- Group IV decarboxylase
- AAA+ ATPase, core domain-containing protein
Sequence:
MRLLSVLVFLISVISIAKADYQYAFCKFNELSIGGVEGIAHLLSTDGTTLNITFDFTTSYAQNTQFAAQILTYGYNPSSMTNLGSVFDPTNVKTAGCPSGTPRAGDIGNIQANGGNVEAQTISLNIPNIKDDANSIIGRSIAIYGGSYDCSDPSKSVIGDMISFCTIGVGNIDYSSFDKSKLTGVNTASSYSNLENAIGLAVVYNTTITKGDYIEGRVLFKALNSSFIQVSAKVSGLSYQAHGFHVHQFGDVSSDNGTSIGGHFLKTGQEHSLPPSGTRHYGDFGNFCAFSQDMMDTGYYYYETDHVTAALVIGRGMAVHNFTDKGNSDVGGSRCGQGVIALIQDADYSLNLPMDWKWDVICANGSYYGDMSTSMNSESYNDNEPGSSSTVIPFFALIIFSIIFALL
Protein: Oxysterol-binding protein (Q9VC05)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD30122p
- AT11025p
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 4-kinase alpha
- Uncharacterized protein, isoform F
- Extended synaptotagmin-like protein 2, isoform C
- Phosphatidylinositol 4-kinase beta
- Cyclin-G-associated kinase
- Vibrator, isoform B
- Phosphatidylinositol 4-kinase type 2
Sequence:
MTDAAGNALAEKGLPEMKGWLLKWTNYIKGYQRRWFVLSKGVLSYYRNQSEINHTCRGTISLHGALIHTVDSCTFVISNGGTQTFHIKAGTEVERQSWVTALELAKAKAIRAIECEEEEETETAHVVPSQEISSVVRDLTDRLESMRTCYDLITKHGAALQRALNDLETNEEESLGSRTKIVNERATLFRITSNAMINAGNDYLHTAEAQGHKWSKMLHHEREQRQRLEEIIEQMAKQQSQMEQAAVLVRQNKPVSSTSGAGTAGSLVTSDEEMEFFDAEEHGYSGSGRSPESSDCERGTFILKMHKRRSSSEDQVEGHLEGSSSESDEQKRTVQTVQQVCLVSAPRVASGGQGDDDDDVDKALPAKESTDSIYGRNWNPDLIKKRRDRVPDKPNHPISLWGIMKNCIGKDLSKIPMPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLGETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNEVKWVVRGTWDMKIEIAPVLKTSGSVSSPTYTTGEFKLAWRRRPAPPDSDKFYNFTTLACQLNEEEEGVAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQRTERRRRENEAEEAAAEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAKAAQNFEGCPDIY
Protein: Drosophila dodeca-satellite protein 1 (Q9U982)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQAAAVMEETNNATTIEQQPIALINGQEQVANEQQPSSPTSVATPTSTTSGGTGNATPAFSYDDLFPALPANTSAQSQSGASGSTLARVTSSQKTHIVHVPCKERKSTESEKFGEGESKRICQQITKETGAQIEIVSGKNQSLTFLIKGKQSELLDARRKILMGFSTQASRQVTVPREHFRVILGKGGQRLREIERVTATRINIPSQSDESEFITIAGTKEGIAQAEQEIRQLSAEQYKKSSDRITVPKVYHPFIVGPYSENLNKLQEETGARINVPPQQVQKDEIVISGEKDAVAAAKAKVEAIYKDMEKKCSTVSVEVAKPKHRYVIGPKGSTIAEILQLTGVSVEMPPNDSPSETITLRGPQVALGNALTVVYQKSNSVKSVEINAAHWIHKYVIGRKGANMKQLEEDCPNVNVNCLEDKIKLEGDPENVDRAVAYLSEIIKNYEENFTFEVMTVNPSYYKHIIGKAGANVNRLKDELKVNINIEEREGQNNIRIEGPKEGVRQAQLELQEKIDKLENEKSKDVIIDRRLHRSIIGAKGEKIREVKDRYRQVTITIPTPQENTDIVKLRGPKEDVDKCHKDLLKLVKEIQESSHIIEVPIFKQFHKFVIGKGGANIKKIRDETQTKIDLPAEGDTNEVIVITGKKENVLEAKERIQKIQNELSDIVTEEVQIPPKYYNSIIGTGGKLISSIMEECGGVSIKFPNSDSKSDKVTIRGPKDDVEKAKVQLLELANERQLASFTAEVRAKQQHHKFLIGKNGASIRKIRDATGARIIFPSNEDTDKEVITIIGKEESVKKAREQLEAIIKECDEVTEGEVSVDPKHHKHFVAKRGFILHRISEECGGVMISFPRVGINSDKVTIKGAKDCIEAARQRIEEIVADLEAQTTIEVVIPQRHHRTIMGARGFKVQQVTFEFDVQIKFPDRDATEPVEGLTNGGSGENGGENEGQEGEQEVEKEAEQEPVRQCDVIRITGRIEKCEAAKQALLDLIPIEEELSVPFDLHRTIIGPRGANVRQFMSKHDVHVELPPSELKSDVIKVCGTPARVAEAREALVKMIEDYEADRADRELRSFVLQVDVDTEFHSKLIGRHGAVINKLRADHDVIISPPKRDEPNDRIISITGYQANAEAARDAILEIVGDPETLHREVIEIDKRIHPHLIGQRRRTIRKIIEDNKVNIKFSADDDNPNSVFISGKIEDVENVKELLFGMAEDYERDYLDNVAIAPPTIGAFLTGQGSGSDAAGASENGFVIKDAPWEKQKQAKNLTAPNTQSQEDFPHFAAGGAPVASTPITSVWGPKN
Protein: RIKEN cDNA 2310061I04 gene (B8JJ69)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MYRPSPGAARRLGPCLRAYQARPQDQLSPRPLPFPPLWPHSTPPTSPSFPPHRSLPPSHPPTHHLPQAPPPPLSQAQALNSLSMVLPPRKREKGPGPELHSGCLDGLRSLFEGPPCPYPGAVIPFQAPGPSHSSPTTPSGDESMEEHLAVMHERLRQELPTLFLRSHDYTIYSMDVEFINEILNIRTKGRTFYVMSLTLCRFLVWNYFAQFRLEILQLTRHPENWTLQARWRLIGLPIHMLFLRFYRRDKEDLYRTFDAFSTFYLNSSGLICRHHLDKLMPSHSPSTPVKKLLVGALVALGLSEPEPSLHLCSKA
Protein: BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) (M0R0I0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADDGSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNALNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQ
Protein: ADP-ribosylation factor-like protein 6 (Q5M9P8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probably involved in membrane protein trafficking at the base of the ciliary organelle. May function in cilia biogenesis. Isoform 2 is required for proper retinal function and organization.
Subcellular location: Cell projection, cilium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}.
Interaction partners:
- ADP-ribosylation factor-like 6 interacting protein
Sequence:
MGLFDKLAGWLGLKKKEVNVLCLGLDNSGKTTIINQLKPSNAQAQDIVPTIGFSIEKFKTSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSGDKLRMVVAKEELDTLLNHPDIKHRRIPLLFFANKMDLRDALSAVKVSQLLCLENIKDKPWHICASDAVKGEGLLEGVDWLQDQIRAMKT