wanglab/gogpt-training-data huggingface dataset:
Protein: 40S ribosomal protein S21, putative (Q385B9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 40S ribosomal protein S14
- 40S ribosomal protein S33, putative
- 40S ribosomal protein S16, putative
- 40S ribosomal protein S5, putative
- 40S ribosomal protein S23, putative
- 40S ribosomal protein S26
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S25
- 40S ribosomal protein S15a, putative
- 40S ribosomal protein S27, putative
Sequence:
MATIGTYNEEGVNVDLYIPRKCHATNSLITSFDHSAVQIAIANVDPNGVIDGTTTTLCIAGYLRCQGESDHAINHLAIAKGIVRIKTGKKPRAKKTKNLKVASGARTQQKGGRNAAGQTKGAAQRGAAQKPTGRPQQAQRQGGRPARTEEGNRQRQGQQRQKPQQQQQQRQQQQQQRGGDRRAPQGRSGKAAPQRK
Protein: WbnF (O51400)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS14
Sequence:
MKIFLTGIAGFIGFHVAKKLVEKGHEVLGIDVLNDYYELKFKHERLEALGFCSKDVKTHKIIKSEKYNNLSFAYLDILNKDKLLELFKDHKFTHVCHLAAQAGIRDSLENPDSYVSINIVGFFNVLDVCRVYKENIEHFVYASTSSVYGINENMPSSEDSITDHPLNLYAASKKSNEMMAHAYSASFNIPTTGLRFFTVYGTYGRPDMALYLFSDGIKNGKAINIFNNGNMARDFTYVGDIADGVYKVLKNPAKSDCNFDVKNPNSSTSSFPYRIYNIGTGHATKLLDFISELEANFDKKALKNYMPMQKADVVESCCDILKLKNDVGYEAKVSIKEGIKEFSQWYKMLESTKKT
Protein: PR domain zinc finger protein 14 isoform X1 (PR domain-containing 14) (F1QWQ9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- CBFA2/RUNX1 partner transcriptional co-repressor 2.
- Nanos homolog 3
- Deleted in azoospermia-like
- POU domain, class 5, transcription factor 1
- Transcription factor AP-2 gamma
Sequence:
MSVSLSSHPAVRDRSLAVYPSLPGAHYADVLKSAHSIFHPLKSLGRMVTDAQTIMPFNFSGATPFFSHNSAIFHEQILNVSNIPYFQHIQPSQSVYNARHEDQSTGSLSDFSSPSSVKSSSALSSPVKDNFSCPQAAHPTPEHARTYSFTEEDLFTVLYGYSKKQGQNAGHAISGLSFPPSTADRQILPVDIEGFELPEGISILQTTCGSLSHYGAFADKSTIPKGTRFGPFQGKLVNTSEIKTYDDNTLMWEIFENGRLSHFVDGRGAPGNWMSLVKCARFPEEQNLIAVQCDGQIYYEACKEIRAGQELLVWYGDCYVQFLGIPLTLKEFIDDSEALPAEDSGEGFKCDRCGKVFAYKYYRDKHLKYTRCVDQGDRKFPCHLCNRSFEKRDRLRIHILHVHEKHRPHKCSVCGKSFSQSSSLNKHMRVHSGERPYKCVYCNKAFTASSILRTHIRQHSGERPFKCKHCGKAFASHAAHDSHVRRTHAKDKQLSCDVCGATFQEAQELKYHMKAHKKRPLLESSVVPPADENALFSTKESLHAQTQLADTFSFPGMTSISSEYRPWN
Protein: Protein ERP6 (P53198)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in vesicular protein trafficking.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Endoplasmic reticulum vesicle protein 25
- Protein ERP1
- Protein ERP4
- Protein ERP3
- Protein ERP2
- Endosomal protein P24B
- Regulator of rDNA transcription protein 6
Sequence:
MLSHYIFLAFVLLPFRVSAFYFYGYGGDRKCFLKELSKDTLLKGSYNLEVYDDKLADYALPSYNDYGIVIDVEEVFDNNHRVVHQQGSPSGDFSFLALESGEYKICLQSRVNNWVGKTKTKLEIEFEVGFEAMLDMQRKETLESLHGKVSILNSKIVDIRREQQLMREREESFRDISESVNSRAMWWTVTQVTLLIIICVWQMKSLRSFFVKQKVL
Protein: High-energy light unresponsive protein 1 (Q17990)
Organism: Caenorhabditis elegans
Function: Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior. Directly senses and absorbs both UV-A and UV-B light with very high efficiency. Absorption of UV-B but not UV-A light shows resistance to photobleaching. In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation. Might have a role in response to white light exposure.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27863243}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- G protein-coupled receptor
- Probable G-protein coupled receptor egl-47
- Gustatory receptor
- LITAF domain-containing protein
Sequence:
MPPPSSHSNIFHSTFKHTVKETMANAKKTMIAKILSSRNKWAICDRTLYPIYYLLLILGLNQSIRPNNSLLFRIYSWLVFCLLLFTTLRKFNQVGVRPNGTRENLQEFFANPRSMITLCNALIMLSGLLASLQLYTLGAKRLKPLKILCQFSLNVRTKQAERRQFMINTFLAVFSGLLALTMAATYAMSKWGYILYIVGTPNLDTETIFCVLLDSYALFVSRAAISALAILFYQHCSVIRRSIKHLINEMVPAEQDECPLPESSLQKIHDCQISYQRIFNGKAVIEEYYSFVLFYSYGVCIPIFCFLMFVGMSAQSICWSEVVSIVIWIVNAILVLLLFSLPAFMINEDGDRLVASSFRMYHETFHEERDLTVLSQMTFFTFQIHSTKLTLSACNYFYMDRSILLSLFSAILTYFLILWEFDIKNNQSLQNIANHTIHT
Protein: Thyroid hormone receptor interactor 10 (M0R0F9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTLN
Protein: Patatin-like phospholipase 1 (EC 3.1.1.4) (PfPATPL1) (W7K139)
Organism: Plasmodium falciparum (isolate NF54)
Function: Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids such as phosphatidylcholine. Involved in gametogenesis; however, it is not clear whether it is involved in gametocytes development in host erythrocytes or in gametocyte activation in the mosquito midgut. Involved in gametocyte development in host erythrocytes; however, not involved in gametocytes activation including male gamete exflagellation. Involved in the rounding up of gametocytes following activation in the mosquito midgut; however, not required for gametocyte development in host erythrocytes. Required for exflagellation of activated male gametocytes. Involved in gametocytes egress from host erythrocytes by promoting the relocalization of perforin-like protein PLP2-containing vesicles to the periphery of gametocytes; PLP2 secretion is required for permeabilization of the erythrocyte membrane and thus, promotes gametocyte egress. Dispensable for asexual blood stage development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:31413195, ECO:0000269|PubMed:31734953}.
Interaction partners:
Sequence:
MSDDDDKIYIYSDLFSKNFSDDEKDDSYEREKQVYSGSETQNAENEYSKLRAQNSTILNNYFDNDNIKNVENLKSNDPDQIDLILFPVNKNYYMNLFDGQLIENIHSIKLRKAGFYAIYVENNNNSKWDGIYFGLSRMQVELDYKLITKKNKDGGEYEKRNTSSYDNTESVQNTVGSEKEETENKNEETSNYNSNLNNEINKICKYNLDQTDILLDDSNSERRRNSKFKIKNTNYYDNLMLQNKYTNSILYDDDDDKNNTETYTCTFKTEDQIRVPSQKKKYIYLYNKYDNATLDLNVHTYMSLGMSILCKYSLLYCGKYNHIPRDPYTPFKKPVSILSLDGGGILTISTLLVLNRLEAELRKEIGSDDIKLIDCFDMVCGTSAGGLISLALLREIDLQDVSNMWPSTIKKVFEGNRNIISGIFFEGYDVNNVKDVFLERMGNKFMSSYKKFYCFVTATDVKHKPYKLFLIRNYTHKYNSINAESYDGINKVPLWLAAWATASAPTYLKGPSAEDIKKLGINIKPEIHLVDGALKASNPALIALEECARLNNKNLSTFIKEDLDTLVSIGTGQVPTKLTQSGASSKSASTFEILINSTHLLTRANDTHREVLQRLADRENTYFRFNVPHIGDIEIDSQDVRDFDLISKATQDYLFDEKFYEIKRLAHKLANNYIRSKYL
Protein: Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) (Alpha-2D adrenergic receptor) (CA2-47) (P22909)
Organism: Rattus norvegicus (Rat)
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit alpha-11
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Alpha-2B adrenergic receptor
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
Protein: Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC 2.4.1.15) (Trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (A0A384JAD8)
Organism: Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Function: Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process. The disaccharide trehalose serves as a storage carbohydrate that is mobilized during conidial germination. Trehalose also serves as a protectant for cell integrity during stress.
Interaction partners:
Sequence:
MPSVAGEEPKASSRLLLVSNRLPITIKRTEDGQYDFTGSSGGLVTGLSGLAKTTTFQWYGWPGLEVPDAEAKPLVKRLKDEHGAHPVFVDDELADKHYNGFSNSILWPLFHYHPGEITFDESQWMAYKEVNRLFAKTIAKDVQDGDLIWVHDYHLMLLPEMLRDEIGTSKKNVKIGFFLHTPFPSSEIYRILPVRESLLLSVLHCDLIGFHTYDYARHFLSSCSRILETQTTPNGVEFRGKYVTVAAFPIGIDPEKFIETLKKPKVEERIAQLERKFEGVKLIVGVDRLDYIKGVPQKLHALEVFLTEHPEWIGKVVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGRFGTVEFMPIHFLHQSVNFDELTALYAVSDACLVSSTRDGMNLVSYEYIATQRKRHGVMILSEFTGAAQSLNGALIVNPWNTEELADAIHDAVTMSPEQREINFKKLEKYVFKYTSSWWGESFVSELQRISEHAAKKSNSKGTVDKMPDLVEGVQQFNLGEQREEGRLEPGEFDD
Protein: Lysophosphatidic acid receptor 2a (F1QFF1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell surface {ECO:0000256|ARBA:ARBA00004241}. Endosome {ECO:0000256|ARBA:ARBA00004177}.
Interaction partners:
- Lysophosphatidic acid receptor 1
- G-protein alpha 12 alpha 12) alpha 12a)
- Guanine nucleotide-binding protein
- G-protein alpha 13a, alpha 13a)
- Lysophosphatidic acid receptor 4
- Lysophosphatidic acid receptor 2b
- Transmembrane protein 169a.
- Solute carrier family 10 member 4.
- Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
- Lysophospholipid acyltransferase 2
Sequence:
MVFNSCEAFDNPVSYFYNRTGKPISPNWRTHDFVVVGLGLPICVFIILANMLVIAAIIVNRKFHFPIYYLLGNMAAADLFAGISYSYLVFHTGPWTINLTIKEWFVRGALINMSLTASVVNLLAVAVERHQTIFTMQLHTTMTRRRVVMLIVTIWVVAVVMGLVPTMGWNCVCDQLGCSTVAPLYSRSFLVFWAILNLMAFFIMVAVYTHIFIYVRRRSQVMSPHTDQPSNNQTVISLMKTMSMILGAFVICWTPGLVILLLDGLKCIECHVLKYEKYCLVLAECNSLVNPIIYSFRDEDMRTTYKRILCFPWRRMRPHEGPSGIRFEPVKTGAPPEKNSQNSSSPEAAPPQSPLS
Protein: Regulator of G-protein signaling 14a (Regulator of G-protein signalling 14) (Q7SXC7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVAIKAISQSFCRLARGASLQIKFNKSRVLKMRSSECQTQAVSDGELNLRLSSCGSSSSLSESSSRSGGSQAADGPASRVVSWAVCFEHLLEDHVGVRYFTEFLRSEVSAENILFYQACEKFKKIPPSRLEEMKKEARLIYDTFLSESSLHAVNIDDTAQTEERELETPTPDMFNKAQAQIFKLMKMDSYTRFVRSPLYQNCMLACVESRPLPSIGTPEPKSKMSKKSATPPSNRKSVELKVPSSDSKTSRKKRLENRGSWGADQSFERMAVSRKESQISVKSNSSLELVSGSGRVENGRCSVAVSDPEALSSGSPTADKYCCVYLPDGTASLVSARAGLSLRDMISSLCEKRAFPLRDVLLYLRGKDKPLSLDQDCSMFGDQQLSLELKITFALEIAFLGRTIGIIAKPSKSVGEALSSVLEKQQLRPQDVQLSLSGSNDALNMSTSVFRLANKTVRLDRAALEIQTSSPSARANSRGRKHQDVDGLVELLNRAQCSRADDQRGLLTKEQLEIPQFLQLPAGGAEDQECAL
Protein: CHHC U11-48K-type domain-containing protein (A3QMD6)
Organism: Caenorhabditis elegans
Interaction partners:
- Tudor domain-containing protein
- 3'-5' exonuclease eri-1
- Uncharacterized protein
- Nuclear RNA export factor 2
- NTF2-related export protein
- Small RNA 2'-O-methyltransferase
Sequence:
MASGESEAPGTSKNDRFSITCPYNSDHKVSMEEFNTHLWKCRTEKLHFYPHSLKLKRCSYNMRHFLPEEELQFHEIFCKRQSADLRRQLSLEPLELNVAEHLAAQKLRKEYEKDEESLDGSDDSDEDEEEKNLSVTSEIEKSDVEEVEMMLETINRLAYLEMKNDNLIL
Protein: Probable dual-specificity RNA methyltransferase RlmN (EC 2.1.1.192) (23S rRNA (adenine(2503)-C(2))-methyltransferase) (23S rRNA m2A2503 methyltransferase) (Ribosomal RNA large subunit methyltransferase N) (tRNA (adenine(37)-C(2))-methyltransferase) (tRNA m2A37 methyltransferase) (O83107)
Organism: Treponema pallidum (strain Nichols)
Function: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01849}.
Interaction partners:
- Methionyl-tRNA formyltransferase
Sequence:
MEWCCALSGLLPEEIQKVCAFAERFRGVQVFRWIAAGCTDFHAMSDLSSETRARLARACVISDTRVYTTLRDVDGTLKLGIELKDKRRVEAVLLVDQVSRKTACLSCQVGCPMACAFCQTGQLGFARNLSASEIVEQFLHLERCVGTLDNVVFMGMGEPMLNLDAVCRAIEILSHPQGRDLSEKRITISTSGHCRGIYSLADRALQVRLAVSLTTANAPLRARLMPRAAHDSLAKLKSAIRYFNEKSGKRVTLELALMRGVNTSERHAQEVIDFAHGLNVHVNLIPWNPVASIHFETPREVEVAHFEALLMRARIPVTRRYQRGNGIGGACGQLGKTAGV
Protein: Fructose-bisphosphate aldolase (EC 4.1.2.13) (A6ZI46)
Organism: Mus musculus (Mouse)
Interaction partners:
- Triosephosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
- Transketolase-like protein 1
- Transketolase-like protein 2
- Transketolase
- Transaldolase
- ATP-dependent 6-phosphofructokinase, muscle type
- Fructose-1,6-bisphosphatase 1
- ATP-dependent 6-phosphofructokinase, liver type
Sequence:
MATHRQDVSIFNMTRLSLAMAFSFPPDANEQPHSGLDNTHQQTKELGKESTTTGTMPCPYPALTTEQKKELSDIAHRIVAPGKGILAADESIGSMGNRLQSIGTENTEENRRFFRQLLLTADDRVNPCIGGVILFHETLYEKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGKHTPSPLAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLSCCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACTQKFSNEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKEENLKAAQEEYIKRALANSLACQGKYTPSGKTGATASESLFISNHAY
Protein: Uncharacterized RING finger protein C548.05c (Q9P3U8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Polyubiquitin
- FACT complex subunit spt16
- Ubiquitin-conjugating enzyme E2 16
- Ubiquitin-conjugating enzyme E2 4
- Histone H4
Sequence:
MVKRSSHRQVVLDEDDEENYNNNLDDEKMEVLLIPQSNSTTFASSDATQMYKKSRISSNSENKKQIPDTKTLLETFQKIKKTLECPICTEALQRPFTTHCGHTYCYECLLNWLKESKSCPTCRQKLYTQPSPAYLVYEIMNVVAASNSGFPLVGINENPAKKQKEVLFDGMFKQEDSHYPRSILVDSEDGVLRCARCQWELENPYHCDHCGFQISDDQDSGREWFWDGENAESDSSLNGDNTRGGNISTNRAFNNMGHAPITAVPQDWLRFDEGEEFVGSDLESDFSGPGEYDVDDGFIDNRATSQLSPVESDDDFVAPVNGSNGNGITALDSTDSEEIDIMNGFDEERDSGGTNMVSRSETCYNDGQRYDELRRELADIQNESLDSLNSSSNNSPSHNNIHSRQHPFSSDEDEGNIVTNGTGLRSSQSSSQNRGFDLEPYSEVFTASYPRRQARRTRTIQLDSDEES
Protein: Histidine-containing phosphotransfer protein 1 (OsAHP1) (OsHP1) (OsHP2) (OsHPt1) (OsHpt2) (Q6VAK3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay (By similarity). Functions as positive regulator of the cytokinin signaling pathway. May play a regulatory role in salt and drought tolerance during plant development.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22383541, ECO:0000269|PubMed:24578505}. Nucleus {ECO:0000269|PubMed:22383541, ECO:0000269|PubMed:24578505}.
Interaction partners:
- Probable histidine kinase 5
- Probable histidine kinase 3
- Probable kinase CHARK
- Probable histidine kinase 6
- Probable histidine kinase 4
- Two-component response regulator ORR26
- Os07g0576700 protein
- Probable histidine kinase 1
Sequence:
MAAAALTSQLNALVNNMFAMGLLDDQFQQLQMLQDSTAPDFVSEVVTLFCDDGERIICELSRQLEKPNVDFDRVDSYVHQLKGSSASVGAQKVKNTCIQFREFCQQRSRDGCLKTLDLVRTEFYDLRNKFQAMLQLEQQIQACYPKH
Protein: Protein shortage in chiasmata 1 ortholog (EC 3.6.-.-) (Protein ZIP2 homolog) (MZIP2) (Q5VXU9)
Organism: Homo sapiens (Human)
Function: ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures. Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA. Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (By similarity). Required for proper synaptonemal complex assembly and homologous chromosome pairing (By similarity). Requiref for recruitment TEX11 and MSH4 to recombination intermediates (By similarity).
Subcellular location: Chromosome {ECO:0000250|UniProtKB:A2ALV5}. Note=Localizes to meiotic chromosomes; associates with mid-stage meiotic recombination intermediates. Localization requires meiotic double-strand breaks (DSBs) recombination intermediates catalyzed by DMC1. {ECO:0000250|UniProtKB:A2ALV5}.
Interaction partners:
- Testis-expressed protein 11
- MutS protein homolog 4
- Probable ATP-dependent DNA helicase HFM1
- Probable E3 SUMO-protein ligase RNF212
Sequence:
MTDTSVLDQWKASFFVEDFLEKKTITRMVTQINCEFEEVVPSSNPDSQIEVEEVSLYTHMDYNEVFTPVSCLEKCSALQNQNQDLFIDDKGILFVSSRKHLPTLPTLLSRLKLFLVKDPLLDFKGQIFTEANFSRECFSLQETLEAFVKEDFCMDKVNFCQEKLEDTICLNEPSSFLIEYEFLIPPSLKPEIDIPSLSELKELLNPVPEIINYVDEKEKLFERDLTNKHGIEDIGDIKFSSTEILTIQSQSEPEECSKPGELEMPLTPLFLTCQHSSVNSLRTELQTFPLSPVCKINLLTAEESANEYYMMWQLERCRSPLNPFLLTVPRIQEPHSQYSVTDLKKIFSVKEESLVINLEKAEWWKQAGLNLKMMETLEHLNTYLCHDNLSSNDTKIEIFLPTKVLQLESCLEHKSHSSPIALIDEKSTNAHLSLPQKSPSLAKEVPDLCFSDDYFSDKGAAKEEKPKNDQEPVNRIIQKKENNDHFELDCTGPSIKSPSSSIIKKASFEHGKKQENDLDLLSDFIMLRNKYKTCTSKTEVTNSDEKHDKEACSLTLQEESPIVHINKTLEEINQERGTDSVIEIQASDSQCQAFCLLEAAASPILKNLVSLCTLPTANWKFATVIFDQTRFLLKEQEKVVSDAVRQGTIDEREMTFKHAALLHLLVTIRDVLLTCSLDTALGYLSKAKDIYNSILGPYLGDIWRQLEIVQFIRGKKPETNYKIQELQCQILSWMQSQQQIKVLIIIRMDSDGEKHFLIKILNKIEGLTLTVLHSNERKDFLESEGVLRGTSSCVVVHNQYIGADFPWSNFSFVVEYNYVEDSCWTKHCKELNIPYMAFKVILPDTVLERSTLLDRFGGFLLEIQIPYVFFASEGLLNTPDILQLLESNYNISLVERGCSESLKLFGSSECYVVVTIDEHTAIILQDLEELNYEKASDNIIMRLMALSLQYRYCWIILYTKETLNSEYLLTEKTLHHLALIYAALVSFGLNSEELDVKLIIAPGVEATALIIRQIADHSLMTSKRDPHEWLDKSWLKVSPSEEEMYLLDFPCINPLVAQLMLNKGPSLHWILLATLCQLQELLPEVPEKVLKHFCSITSLFKIGSSSITKSPQISSPQENRNQISTLSSQSSASDLDSVIQEHNEYYQYLGLGETVQEDKTTILNDNSSIMELKEISSFLPPVTSYNQTSYWKDSSCKSNIGQNTPFLINIESRRPAYNSFLNHSDSESDVFSLGLTQMNCETIKSPTDTQKRVSVVPRFINSQKRRTHEAKGFINKDVSDPIFSLEGTQSPLHWNFKKNIWEQENHPFNLQYGAQQTACNKLYSQKGNLFTDQQKCLSDESEGLTCESSKDETFWRELPSVPSLDLFRASDSNANQKEFNSLYFYQRAGKSLGQKRHHESSFNSGDKESLTGFMCSQLPQFKKRRLAYEKVPGRVDGQTRLRFF
Protein: Transcription factor ORG3 (Basic helix-loop-helix protein 39) (AtbHLH39) (bHLH 39) (OBP3-responsive gene 3) (Transcription factor EN 9) (bHLH transcription factor bHLH039) (Q9M1K0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor bHLH47
- Fe
- Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
- Ferric reduction oxidase 2
- Transcription factor bHLH104
- Transcription factor ILR3
- Ferric reduction oxidase 3, mitochondrial
- Transcription factor bHLH115
- Transcription factor bHLH34
- Probable nicotianamine synthase 4
Sequence:
MCALVPPLFPNFGWPSTGEYDSYYLAGDILNNGGFLDFPVPEETYGAVTAVTQHQNSFGVSVSSEGNEIDNNPVVVKKLNHNASERDRRRKINSLFSSLRSCLPASGQSKKLSIPATVSRSLKYIPELQEQVKKLIKKKEELLVQISGQRNTECYVKQPPKAVANYISTVSATRLGDNEVMVQISSSKIHNFSISNVLSGLEEDRFVLVDMSSSRSQGERLFYTLHLQVEKIENYKLNCEELSQRMLYLYEECGNSYI
Protein: G-protein coupled receptor 1 (O04714)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with GPA1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate(IP(3)) as a second messenger. Promotes PI-PLC activity and IP(3) accumulation. Involved in the blue light (BL) signaling. Together with GPA1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings. Probably involved in cytokinin signal transduction. Plays a positive role in gibberellin- (GA) and brassinosteroid- (BR) regulated seed germination, probably independently of a heterotrimeric G-protein. Mediates seed dormancy abolition, and promotes seed germination and flowering.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15181210, ECO:0000269|Ref.7}; Multi-pass membrane protein {ECO:0000269|PubMed:15181210, ECO:0000269|Ref.7}. Note=Localized to the outer edge of the leaf epidermal cells in a punctuate pattern.
Interaction partners:
- Guanine nucleotide-binding protein alpha-1 subunit
- LanC-like protein GCR2
- GPCR-type G protein 2
- GPCR-type G protein 1
- Guanine nucleotide-binding protein subunit gamma 1
- Guanine nucleotide-binding protein subunit beta
- Regulator of G-protein signaling 1
- Guanine nucleotide-binding protein subunit gamma 2
- Guanine nucleotide-binding protein subunit gamma 3
- Pirin-1
Sequence:
MSAVLTAGGGLTAGDRSIITAINTGASSLSFVGSAFIVLCYCLFKELRKFSFKLVFYLALSDMLCSFFLIVGDPSKGFICYAQGYTTHFFCVASFLWTTTIAFTLHRTVVKHKTDVEDLEAMFHLYVWGTSLVVTVIRSFGNNHSHLGPWCWTQTGLKGKAVHFLTFYAPLWGAILYNGFTYFQVIRMLRNARRMAVGMSDRVDQFDNRAELKVLNRWGYYPLILIGSWAFGTINRIHDFIEPGHKIFWLSVLDVGTAALMGLFNSIAYGFNSSVRRAIHERLELFLPERLYRWLPSNFRPKNHLILHQQQQQRSEMVSLKTEDQQ
Protein: Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease (ESCRT-I complex subunit VPS23) (Vacuolar protein sorting-associated protein 23) (P25604)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1.
Subcellular location: Cytoplasm. Endosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Vacuolar protein sorting-associated protein 28
- Vacuolar protein-sorting-associated protein 36
- Protein SRN2
- Vacuolar protein sorting-associated protein 27
- Multivesicular body sorting factor 12
- Vacuolar-sorting protein SNF7
- Vacuolar protein sorting-associated protein 20
- Vacuolar protein-sorting-associated protein 25
- Vacuolar-sorting protein SNF8
- Polyubiquitin
Sequence:
MSANGKISVPEAVVNWLFKVIQPIYNDGRTTFHDSLALLDNFHSLRPRTRVFTHSDGTPQLLLSIYGTISTGEDGSSPHSIPVIMWVPSMYPVKPPFISINLENFDMNTISSSLPIQEYIDSNGWIALPILHCWDPAAMNLIMVVQELMSLLHEPPQDQAPSLPPKPNTQLQQEQNTPPLPPKPKSPHLKPPLPPPPPPQPASNALDLMDMDNTDISPTNHHEMLQNLQTVVNELYREDVDYVADKILTRQTVMQESIARFHEIIAIDKNHLRAVEQAIEQTMHSLNAQIDVLTANRAKVQQFSSTSHVDDEDVNSIAVAKTDGLNQLYNLVAQDYALTDTIECLSRMLHRGTIPLDTFVKQGRELARQQFLVRWHIQRITSPLS
Protein: Extracellular leucine-rich repeat and fibronectin type III domain-containing 1b (Protein ELFN1) (F1Q7Y5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MTEAQMSISSGSSGHGGGMVTSALLCWAVALVFLSLTRVPVVQGDCWLIEGEKGFVWLAICSQNQPPYENIPMHINSTIVDLRLNENKIRSIHFSSLSRFGNLTYLNLTKNDISYIEDGAFSAQFNLQVLQIGFNKMRNLTEGMLRGLGRLQYLYLQANLIETVTANAFWECPAIENIDLSMNRIQQLDGATFRGLSKLTTCELYANPFSCSCELLGFLRWLVAFPNRTSERMACDTPAGFSGYSLLSQNPRMPRYRNAFHALSSVCTDDNVTPYLHGSPDGGIPTRLPDLSPCGLDDCSSGTFPEETISISPTFLDSDARPIMKLKEVTHTSAVITIQIPNPFRKMYILVLYNNSFFTDIQNLKSQREEIELQNLKSHTNYTYCVASIRNSLRFNHTCLTISTGPRTLQERVVNDSTATHYIMTILGCLFGMLIVLGVVVHCLRKRKKQDEPKSKKLEKMKRNLIEMKYGTELEQGTISQLSQKQILSAGETVQRMPYLPAASDTDQYKMQEISGTPKTTKGNYMEVRSEQPERSIRECSVPPSETSQGSVAEISTIAKEVDKVNQIINNCIDALKSDSTSFQTAKSGAVSTAEPQLVLISEHPPGKSGFLSPVYKGGYHHPLQRHHSMDAPQKRASTSSSGSLRSPRSFRSEGAYRSESKYIEKASPQDESGIITVTPAAAILRAEAERIRQYSEHRHSYPGPHHIEESIEVSGSRKSSILEPLTRSRPRELSYSQLSPQYHNLSGYSSPEYSCRPSLSLWERFKLHRKRHRDEEEYIAAGHALRRKVQFAKDEDLHDILDYWKGVSAQQKS