wanglab/gogpt-training-data huggingface dataset:
Protein: LD15472p (Q8SX82)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTHYVRHDYFHNTQNGALSSDTSRISYSQISYETQPSREYFSESYALSNQGPEECSRVSHLNSDTVLTTVDNSNNSYGYDYLECYGANIQCDPEEDSVDNWNENTSVVADQYGLGHNNLNCTSSKLLPKLPNIENGRGSSNACAPQMDVKFNTKGMCIKIDHSYGVCMAKAHDFVGRLSPSDYQNILGNNLNGYAGCAYSSTFLDNAMSSAPLRVLPQSPRCSSYLGRNIIGFNADAAQRDGRGFDTDQTDAMGSESSTYEVYEKMQRPYTSMLPLDYSDYQEGCYNTDNLSTYSDTPPSNNTQLKRQMQRKISLMMAMTTASVIASGEIRVPVHSKQSKKSTEIQTDSIIGNTISTNAAARDLDRCLATESCEVIVDTRDSGSVTSFPSSAVTAITKTRKLPKVLPTPLCKSSRHPITIATDALSSSYTSDPLPEKSHRPKQLPKLPISLPQSNDRASLNSNWATPPAPDALPFNSFDHKSASSPTPTTTITKDTETTSYLVETDFIGARHNALYQYDSKEPNIVFSDKSVEAEHSPTWTPLSPIQSKQSPCPPVALPSNIMQNVSLTCHLPEIEATRSDIEREPESSSIEPILEIEKLADPYSGPGSALFNISEYLKPYTLNKPILSEEKKNHIANAASTSTTTPLNITSDDEFSSYSNKWTSTCVNFQPLDVESSLNISLKVNAGTNQAELLMTPLKSSTPLFISSNGTSDNFNLRKSSPPDSAFTTTVNVNSFETVLVSGSQTASPSPSNLKSPPSIAPLLSYSDYMKQFELPELPQPIMDLSENDTATQSDSFNVINNTLTNADNLNSYNQMDVESKSSLQLPSYSSESFDPCSVPSFSIKNKEYKIVEKLDSLSNVESVESPKTLVSPVNPLNCSKLLPGTESIVSNDVAFDDTFYDSFNVDIKELTAFVDHVAPEDGLYNFPNDKTSVEFSFDKTEDTIDMNQNLSSGECGYYKPSQAQQKASVVASAASSVLDGISKGLKGGLDGVFSGVSSTVDVTQSNPSSKRGFSFNLASKIVPSVGGLLTSTSSTSIKQTGSETNPTLILISPENVSSRNSNYIPTTSPSCTQKNGEENLYSATVHNKSTKSNSYYNEVGEISSTLVRNVCDSYDNSYDEMILTNEMVNIGMLDSESEFGLIENSYSYQVPDNEQIDSVNSYNNKTQNVTNNGIEKANTKNKPVPLHDPPTKKASTVGMFGSILGKAAAAVQSATQAVNQSASSVASVVAQKPTIVPRTNNVLLLSSVCSPNEIKRNSSSVEFDSEYGYQMPDVESLSSHYANTGGDYDNSNMKIHEFGTYADDRPYADYHTNGNQSQFKEEAVIPGEPEVINTNILPIGPQATGKKLPTVNGKSALLIKQMPTEVYDDESDTDELDVSPSTGKVPSYSIYSEQEDYYMDLQQTTPSIQPNGFYEQVNNGYDYREDYFNEEDEYKYLEQQREQEEHNQPKNKKYLKQAKISKIQPPSLDFIDVGQDDDFIYDNYHSEDDSGNYLEGSSSGSVGPIEGSIIKVDSNIEASFASLNKKSDSFTPTNDSLQKHDTVIGESTTKLTRLRTEKMCPDVDEEDENLSDHVSDLTDLSKLISQKKKKK
Protein: Protein WVD2-like 4 (Q9SJ62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8GYX9}.
Interaction partners:
- BAG family molecular chaperone regulator 8, chloroplastic
- Glycosyltransferase
- E3 ubiquitin-protein ligase MBR2
- Uncharacterized protein
- HEAT repeat-containing protein
- TPX2
Sequence:
MASEDLNIVAESKKGEENVIVDNSKDMNRPENLDLSTEKTDTANENGPKDEASKLVKEADLPESGTSVKSKTAKDNKPVKRKSGTFSRSPRFMSQSSSFPTKGAYTDITRKSIDATTSKTSLKPVVAGGSKPKATPSSSSGVSAKRTSLVSAPLKKQTMPVKTISKDAASGPTSKLGDEGSKSIKEETAGKDVEEAGSTTAVVADKVSNPLKAEMASKDDEDTRSTTTSTSTPRGRRSSVGSASGFSFRLEERAEKRKEFYMKLEEKIHAKEVEKTNLQAKSKESQEEEIKRLRKSLTFKAGPMPSFYKEPPPKVELKKIPTTRPKSPKLGRRKSSSDATGGEAAPRVTKPKDSSSSTVKKPITKSQPKLETQEKSVKAKEKKKKVKKEEAEKRGEEEKATAVAAKPEEQKPNSNNIQVKAEIMASEVVVGG
Protein: beta-fructofuranosidase (EC 3.2.1.26) (E3T5W6)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Vacuole lumen {ECO:0000256|ARBA:ARBA00004410}.
Interaction partners:
- fructokinase
- fructokinase
- fructokinase
- fructokinase
- fructokinase
- fructokinase
- fructokinase
- fructokinase
- fructokinase
- fructokinase
Sequence:
MPKMEASSSTSHDPALFHAPLLYHPRRRSSRPLKGFAVIIGSVVFLLSLVTLIVNQSPEPLASNPSSVTEAGSYSMAAQPRGIAEGVSAKSNPSLFDKVGFNWTNAMFYWQRTAYHFQPQKNWMNDPDGPLYHKGWYHLFYQYNPDSAIWGNITWGHAVSTDLIHWFYLPLAMVPDQWYDINGCWTGSATLLPDGRIVMLYTGSTNDSVQVQNLAYPANLSDPLLLQWLKYPGNPVVVPPTGIEDEEFRDPTTAWLGPDGSWRIVVGTRFNTTIGTALVFQTTNFSDYELLDGVLHAVPGTGMWECVDFYPVAINGSVGLDTTALGPGIKHVLKASLDDTKVDHYAIGTYDMITDKWTPDNPEEDVGIGLKVDYGRYYASKTFFDQSKQRRILYGWVNETDSEADDLEKGWASIQTIPRSVLYDNKTGTHLLQWPVEEVESLRLNATVFKDVVVEAGSVVPLDIGTATQLDILAEFEIETLVLNSTEDEVSDCGDGAVDRSTYGPFGVLVIADDSLSELTPIYFRPLNTSDGSLETYFCADETRSSKAPDVTKRVYGGKIPVLDDENYNMRVLVDHSVVESFGGGGRTVITSRVYPTEAIYGAARLFLFNNASGVNVKATLKIWEMNSAFIRPFPFEETLFQEMVAST
Protein: DNA repair protein Rad21 (Q9UB09)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPKVKLALRTSGHLLLGVVRIYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEGHREANVNAITLPEVFHDFDTALPELNDIDMEAQFSINQSRADEITMREDYGSLSLSLQDDGFGDIGFEAETPEIIRCSIPSNINDKIFDNDVLENIESLDPHSLDAHADMPGSRLDGDGFGDSFGQPALFEDDLFGDPSQPVEQITKESTTVLNADDSDEDAIDNIHNVPSPATSLVNSIEDEKEENNLNGHASVSENVPMNEITLVQNEDEGFALAPLDVSMYKGVTKAKRKRKLIIDEIKNISGEEMKAQLADTSDILTTLDLAPPTKRLMYWKETGGVEKLFSLPSRSIPARALFGNYNRQLFSHSTFFEDFSSVVPMEILALEFYTKENENALIIFNKKGRKRKNDNMSNLFLDHVPDSVVQSLEAPEVLRANHKSLGVSTVSVEIVSKEQESISCQNELTFFDNMRSPDLLSLNEMEQFSSINELPLTPRNMNHEMGDDFNQGDSTPAGLDHGHATPQHGNIGEMDHDSVIPTKKTAVILNESVGTSVLSDNGVSKRTNNILKGWDNYEIPSFVGQNHGDEQMENETDEQFEERVLNKRAAHLFIDVRAHFIAKDSLELSQLTSGNSRKQAAQKFYSLLVLKKFKVLHIDQSAPYADITITRGPTFENPKI
Protein: LIM zinc-binding domain-containing protein (G5EEA4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPIGGGSGSSSGSISREIRIESMNLTDVEDGARCRDKECHLGWKQHPWRKVCVHCKSDRSDHELPPNQALNVYNRLGIQPPAGMPQSGVAEPEVPGSVGHGYAWVPPGLSRKKVEEYMSQLPNNVVPRTNSNGEKLREKQLLLQLPRQDLSVAYCRHLTSQTERKVYEEFVNARNEIALDIGYVSSNINKAMECHKCSGILETNEMAVIAPKLGDSTGWHPACFTCQACEQLLVDLTYCVKDNQIYCERHYAELHKPRCSACDELIFAGEYTKAMNKDWHSDHFCCWQCDQTLTGQRYIMRDEQPYCIKCYEDVFANQCDECAKPIGIDSKDLSYKDKHWHEHCFLCSMCKISLVDMPFGSKNDRIFCSNCYDQAFATRCDGCNEIFRAGMKKMEYKGKQWHDKCFCCAHCKLAIGTKSFIPKNDDVFCGPCYEEKFATRCSKCKKVITAGGVTYKNEPWHRECFCCTNCNSSLAGQRFTSKDEKPYCANCYGDLFAKRCNACTKPITGIGGAKFISFEDRHWHNDCFICAQCTTSLVGKGFITDGHEILCPECAKARLMAANS
Protein: Leptin (Obesity factor) (B0M1K7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Fibronectin type-III domain-containing protein
- Fibronectin type-III domain-containing protein
- Leptin B2
- Uncharacterized protein
- Prolactin
- Prolactin
- Motilin/ghrelin-associated peptide domain-containing protein
- Erythropoietin receptor
- Erythropoietin receptor
- Fibronectin type-III domain-containing protein
Sequence:
MDCSMALLLSSLLALFSVGAGASLSLHVVRTKVKDLAQTMVIRIKKLDISPNLIEGMDPFLPAAAVDQHIESLPSIVETMGFYQDLLLVLDWADLKQLVEDTSTMRGLLENWMTSRCPARQQKQTGEGGLSEALKDTTRKYGLSVGPVALNRLKGYLGRLLLNLDQLNYCY
Protein: Guanine deaminase (Guanase) (EC 3.5.4.3) (Guanine aminohydrolase) (Q2UHY8)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- xanthine dehydrogenase
- adenine phosphoribosyltransferase
- Probable guanine deaminase
Sequence:
MTTKTAQVFHGTLIHSKDPQTLEILPNTLLIISATGQIQSLHPSTNPTDIPTLLTQANHNPDTTPITTLSATEFLIPGFIDTHTHAPQWSQRGLGRGIDLLTWLEQITFAHEAKLSDPIYAKQLYRAAVQGSLKQGITTACYYGSRHKDASIILAETCLAIGQRALIGKCNMNRHAPDWYVDSSVDESVSDTVEFIAKVKELDGDTGLVTPVITPRFAITCDETLLSQLGTIVKQNPGIPVQTHFNESHGEVNFTRDLFPQFKNETELYDNYGLLTNRTILAHAIYPQPEEFPRLKELDCGVAHCPIPNTTMDEFMIAPVREYLSRGIKVGLGTDCGGGYSSSMLDVMRAAFMVSVAKQTETEGKDAPLSVAESFYLATLGGARVAGLEDRVGRFAPGLEFDACLVRTGVAEGIMAPVEEEDGVEGVFEKFLMTGDDRNIVRVWVRGREVKGSSSA
Protein: Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) (Q8N3Z6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:21855801}.
Interaction partners:
- Exosome RNA helicase MTR4
- Terminal nucleotidyltransferase 4B
- Terminal nucleotidyltransferase 4A
- Poly
- Poly
- Poly
- Zinc finger CCHC domain-containing protein 8
- Exosome complex component 10
- RNA-binding protein 7
- Exosome complex exonuclease RRP44
Sequence:
MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSEVITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLGCEVDDKDDDILLNLVGCENSVTEGEDGINWSISDKDIEAQIANNRTPGRWTQRYYSANKNIICRNCDKRGHLSKNCPLPRKVRRCFLCSRRGHLLYSCPAPLCEYCPVPKMLDHSCLFRHSWDKQCDRCHMLGHYTDACTEIWRQYHLTTKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPSKLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHYHTSREDKSPKEGKRGKQKKKERCWEDDDNDNLFLIKQRKKKS
Protein: Dahlein-4.2 (P84265)
Organism: Ranoidea dahlii (Dahl's aquatic frog) (Litoria dahlii)
Function: Has no antimicrobial activity.
Subcellular location: Secreted {ECO:0000269|PubMed:11555873}.
Interaction partners:
Sequence:
GLWQLIKDKLKDAATGFVTGIQS
Protein: Protein HUA2-LIKE 3 (HUA2-like protein 3) (F4IZM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that acts with partial redundancy with HULK1 and HULK2. Plays diverse and essential roles in the control of plant development, physiology and flowering time.
Subcellular location: Nucleus {ECO:0000269|PubMed:25070081}.
Interaction partners:
- Uncharacterized protein At1g51745
- Tudor/PWWP/MBT superfamily protein.
- EID1-like F-box protein 1
- EID1-like F-box protein 2
- Uncharacterized protein At5g66000
- KH domain-containing protein HEN4
- EID1-like F-box protein 3
- DExH-box ATP-dependent RNA helicase DExH10
- Phytochrome A-associated F-box protein
Sequence:
MAPSRKRGGGRAAAASSARREWKVGDLVLAKVKGFPAWPAVVDEPEKWGHSADSKKVTVHFFGTQQIAFCNHGDVESFTEEKKQSLLTRRHAKGSDFVRAVKEITESYEKLKQQDQASGPKYAEETTAGSSGNTSQLPQACENLIGSRLDTQIESSSSHGRDELTLLSEDASAAEQMLALRHNTLAHNGACDSAAAKDLCEIATYSSRRRNERVRALKYAPQSIILPVEHSKISSRLELDRVQRSMLQCSDGGPSVNSINGKAIRRRKRIRTSGQSESDDVVSSDLNLHGSDEDNASEIATVESNNNSRNEGNGVDSGSKVEYSDAVGEGCDGGHELNKGLDFHISTMVKRKKRKPTRKRETSDIIDPPAKVEAEGLGPNACDSCQRSQNSHERLNERPCEENGDEHLPLVKRARVRMSRAFYADEKVNASSQVEERSSKDTLLSAALQTSPSVNHENGIGSGHDTSAAEEFNSFELSAKLSGVMVDVVPSHMEKPSDRMSPSVACVQTVGDRQTAVNFHENEFTMTLDDEVTRAQSNQLSSLVETEARVPEVVQGCSEESQTGNCLISETDPIDIQCSHQSEKHETPLNPDIVDSSANKSPGLCSSLDMTTTVVPAQSPHQHKIQEYDSSDHSLVIVGDSLNGKCEKIDYCMTQVVQSQALEPPPPLFCSVVNYQEVENLQETENTLWKENQGSPGKELDSDKQAHMIQNPVLSATESEMIVDDAEPQYETVYSHCADAVENRELEKSCEVDEQKEQMQATNSISVSENFSREKLNSSPARGTPNCNSVCRISTAESENAMQNNSYYSTNVQYGENKSLNVDTVKEESKVETGTTQVKKVVSSDVQCTVESFETALDSLVRTKETIGRATRLAMDLAKFGVSAKAMEILAHTLESESNLQRRVDLFFLVDSIAQCSKGLNGDAGGVYLSSIQAMLPRLLTAAVPAGATTQENRKQCLKVLRLWLERRILPESIVRHHIRELDSLSNVPACLYSRRSARTERALDDPVRDMEGILVDEYGSNSTLQLHGFCIPPILRDEDEGSDSDGGDFESVTPEHESRSLEEHVTPSITERHTRILEDVDGELEMEDVAPPWEGGSSASAITDQADNRESANCLLVPGTSHQNVTSSSPPARPSQNAQLAMSNSYSNGFDYRRNPSMQGDYHAGPPRMNPPMHYGSPEPSYSSRVSLSKSMPRGEGSNFQHRPYPSSHPPPPPPSHHYSYMEPDHHIKSRREGLSYPHRSHYTLEFDERNYQDSYERMRPEPCENRDNWRYHPPSSHGPRYHDRHKGPHQSSSYSGHHRDSGRLQNNRWSDSPRAYNNRHSYHYKQHSEGPVPVGMRDPGTWHQR
Protein: Double PHD fingers 3 (F8W7T1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFYGRINGRNFAASSLPVAFAATPLMLFLPNPQLIFSFPISSRNHITGLMPPGKLKLENLFHMCTRLGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEALLRGEGVEKKVDAREEESIQEIQRVLENDENVEEGNEEEDLEEDIPKRKNRTRGRARGSAGGRRRHDAASQEDHDKPYVCDICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPNHRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSAHLGGEGRKEKEAAAAARTTEDLFGSTSESDTSTFHGFDEDDLEEPRSCRGRRSGRGSPTADKKGSC
Protein: Uncharacterized protein YbiJ (P0AAX3)
Organism: Escherichia coli (strain K12)
Subcellular location: Periplasm {ECO:0000305}.
Interaction partners:
- Pirin-like protein YhaK
- Inner membrane protein YqjF
- Uncharacterized protein YjfY
- 4,5-DOPA dioxygenase extradiol
Sequence:
MKTINTVVAAMALSTLSFGVFAAEPVTASQAQNMNKIGVVSADGASTLDALEAKLAEKAAAAGASGYSITSATNNNKLSGTAVIYK
Protein: Kelch-like protein 35 (Q6PF15)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRQGHAPEESEPGCEAPCAGPCHAQRVLQALNAYRRSGTLTDVVLRAGGRDFPCHRAALSAGSAYFRSLFAAGRPERGPAVVPVVPVAPEAPGTSPAGAAAALAVVLDYVYGAGVRLRAEDEAAAVLALAERLGVAGLREACVRFLEGRLRAANSLALRRVAAAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVVALLADPALGVAREEAVFEAAMRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFILGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRCTSSHGCVTIIQSLGR
Protein: Homeobox-leucine zipper protein ATHB-20 (HD-ZIP protein ATHB-20) (Homeodomain transcription factor ATHB-20) (Q8LAT0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor BIM3
- RING/FYVE/PHD zinc finger superfamily protein
Sequence:
MYVFDPTTEAGLRLEMAFPQHGFMFQQLHEDNSQDQLPSCPPHLFNGGGNYMMNRSMSLMNVQEDHNQTLDEENLSDDGAHTMLGEKKKRLQLEQVKALEKSFELGNKLEPERKIQLAKALGMQPRQIAIWFQNRRARWKTRQLERDYDSLKKQFESLKSDNASLLAYNKKLLAEVMALKNKECNEGNIVKREAEASWSNNGSTENSSDINLEMPRETITTHVNTIKDLFPSSIRSSAHDDDHHQNHEIVQEESLCNMFNGIDETTPAGYWAWSDPNHNHHHHQFN
Protein: Patched domain-containing protein 3 (RND-type protein RNDEu-3) (Q0EEE2)
Organism: Mus musculus (Mouse)
Function: May play a role in sperm development or sperm function. However, does not appear to have an essential role in spermatogenesis or male fertility.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:17904097}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q3KNS1}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the midpiece of the sperm tail. {ECO:0000269|PubMed:17904097}.
Interaction partners:
- Protein dispatched homolog 3
Sequence:
MISSKVAPGEEEQGESPSKVELGEAEEQREAPLEGQLEAVPLDEAGPSWTTGPPLERLPPLGQEAPPPRRCHTNCLEAPLSRGFQRFGATVGANPWLFLLGPALLTASLGTGLIFLPKEKENLEEQYTPIGSPAKAERRFVQGHFSTNDTYRFSASRTSSETNFASILVVSLANSLLEPEIFKEVSKLDQAVQALKVVQENGTQILYQEVCAKYKTLCVPPNPLLFSWQHNSSLNLSDLTFPIHNTPTQLIYLAGFFGGNVLGQMTGKSQRLVESRAMRLLYYLKTEDPEDSERSQAWLTHFLDHFNDMKSSLTLEEIEVVYFSSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRLDCIRNKMCVAVFGVFSVAMSVVSGFGLMLHLGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLSESIRERLSNSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAVMALDGKREVAWSRWLEKPDQKYSSLKKSCCVPFGSLIDKHGEDNHPMNLFFRDYFGPFLTTSKAKFIVVLLYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVIVTESVNYWDNDVRQKLDKCMTQFEENEYVDKNLTEFWLEAYMQYMNSSGNNPNDKNTFMNNIAGFLQFFPIFTYDINISSSNEITSSRGFIQIVDVSSSSNKKRMLLKLRSIAENCEVPLMVYNQAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSTEPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLSAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF
Protein: Transcriptional regulator CRZ1 (P53968)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates PMC1, PMR1, PMR2A and FKS2.
Subcellular location: Nucleus {ECO:0000269|PubMed:10197980}. Cytoplasm {ECO:0000269|PubMed:10197980}.
Interaction partners:
- Calcium-transporting ATPase 2
- Calcineurin subunit B
- Serine/threonine-protein phosphatase 2B catalytic subunit A1
- Calcium-transporting ATPase 1
- Calcipressin-like protein
- Calmodulin
- Vacuolar calcium ion transporter
- Calcium-channel protein CCH1
- Serine/threonine-protein phosphatase 2B catalytic subunit A2
- Vacuolar v-SNARE NYV1
Sequence:
MSFSNGNMASYMTSSNGEEQSINNKNDIDDNSAYRRNNFRNSSNSGSHTFQLSDLDLDVDMRMDSANSSEKISKNLSSGIPDSFDSNVNSLLSPSSGSYSADLNYQSLYKPDLPQQQLQQQQLQQQQQQQQQQQQQQQKQTPTLKVEQSDTFQWDDILTPADNQHRPSLTNQFLSPRSNYDGTTRSSGIDSNYSDTESNYHTPYLYPQDLVSSPAMSHLTANNDDFDDLLSVASMNSNYLLPVNSHGYKHISNLDELDDLLSLTYSDNNLLSASNNSDFNNSNNGIINTADTQNSTIAINKSKVGTNQKMLLTIPTSSTPSPSTHAAPVTPIISIQEFNEGHFPVKNEDDGTLQLKVRDNESYSATNNNNLLRPDDNDYNNEALSDIDRSFEDIINGRKLKLKKSRRRSSQTSNNSFTSRRSSRSRSISPDEKAKSISANREKLLEMADLLPSSENDNNRERYDNDSKTSYNTINSSNFNEDNNNNNLLTSKPKIESGIVNIKNELDDTSKDLGILLDIDSLGQFEQKVGFKNDDNHENNDNGTFSVKKNDNLEKLDSVTNNRKNPANFACDVCGKKFTRPYNLKSHLRTHTNERPFICSICGKAFARQHDRKRHEDLHTGKKRYVCGGKLKDGKPWGCGKKFARSDALGRHFKTESGRRCITPLYEEARQEKSGQES
Protein: 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (Serotonin receptor 1A) (P19327)
Organism: Rattus norvegicus (Rat)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Subcellular location: Cell membrane {ECO:0000269|PubMed:2156831}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08908}. Cell projection, dendrite {ECO:0000269|PubMed:18685031}.
Interaction partners:
- Basigin
- Fibroblast growth factor receptor 1
- Sodium-dependent serotonin transporter
- 5-hydroxytryptamine receptor 2A
- Guanine nucleotide-binding protein G
- Oxytocin-neurophysin 1
- Guanine nucleotide-binding protein G
- Pro-neuropeptide Y
- 5-hydroxytryptamine receptor 2C
- Somatostatin
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
Protein: LIM and SH3 domain protein F42H10.3 (P34416)
Organism: Caenorhabditis elegans
Interaction partners:
- CaLponIn-liKe proteins
Sequence:
MSKKCAREDCGKTVYPVEELKCLDKVWHKQCFKCTVCGMTLNMKNYKGYDKRPYCDPHYPKTVASVMADTPEMRRIAENTKNQSNIKYHAEYEKMKGTKIEIADDPEMERLKKNTQVQSNVSYHGVLDQKARQEEVRPKEEISPNPTPTPISPMNHQSYSAPTQAVAANTHLIYSTEQGGAVSPTPQKSIGSIADYDPMNGQWGTAAAQPRNSEKLGYLKAQVDKGPARFCADFAGAPPPSSNSISSTSPHSTLSSPQSTISPTGKAGFAVKAIYDYAAADKDEISFLEGDIIVNCEKIDDGWMTGTVQRTLQWGMLPANYVQPHKLPTGLHRLS
Protein: Gap junction delta-3 protein (Connexin-31.9) (Cx31.9) (Gap junction alpha-11 protein) (Gap junction chi-1 protein) (Q8N144)
Organism: Homo sapiens (Human)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12154091}; Multi-pass membrane protein {ECO:0000269|PubMed:12154091}. Cell junction, gap junction {ECO:0000269|PubMed:12154091}.
Interaction partners:
- Gap junction alpha-3 protein
- Gap junction beta-2 protein
- Gap junction alpha-8 protein
- Tight junction protein 1
- Gap junction gamma-1 protein
- Gap junction beta-4 protein
- Gap junction beta-1 protein
- Gap junction alpha-1 protein
- Gap junction alpha-5 protein
- Gap junction epsilon-1 protein
Sequence:
MGEWAFLGSLLDAVQLQSPLVGRLWLVVMLIFRILVLATVGGAVFEDEQEEFVCNTLQPGCRQTCYDRAFPVSHYRFWLFHILLLSAPPVLFVVYSMHRAGKEAGGAEAAAQCAPGLPEAQCAPCALRARRARRCYLLSVALRLLAELTFLGGQALLYGFRVAPHFACAGPPCPHTVDCFVSRPTEKTVFVLFYFAVGLLSALLSVAELGHLLWKGRPRAGERDNRCNRAHEEAQKLLPPPPPPPPPPALPSRRPGPEPCAPPAYAHPAPASLRECGSGRGKASPATGRRDLAI
Protein: Bile acid-sensitive ion channel (BASIC) (Acid-sensing ion channel subunit family member 5) (Amiloride-sensitive cation channel 5) (Brain-liver-intestine amiloride-sensitive Na(+) channel) (BLINaC) (Q9R0Y1)
Organism: Mus musculus (Mouse)
Function: Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium and lithium, and is inhibited by amiloride (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q9R0W5}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9R0W5}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acid-sensing ion channel 1
Sequence:
MEHTEKSQVHAEKGLLGKIKRYLSKRPLPSPTDRKKFDQDFAMSTSFHGIHNIAQNQNKVRKVIWLAVVLGSVSLLVWQIYSRLVNYFTWPTTTSIEVQYVEKIEFPAVTLCNLNRFQTEAVSRFGIIFFLWDIVSKVLRLQEISANNTGSPETLDFVTNHQNFSITEFVKNNGFYLNNDTLVHCEFFGKTCSPKDFKHVFTEYGNCFTFNYGENIQNKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGECNPNIKLRNFITYSTYGCLKECKARHIQRLCGCLPFLLPGNGVECDLLEYYNCVSPILDHIERKGLCTMGTHNSSCPVSCEETEYPATVSYSTFPSQRATRFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYFFTNFYWVLIFFLLKILETIQRTSPPQAV
Protein: SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) (Q96B97)
Organism: Homo sapiens (Human)
Function: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20221403}. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse, synaptosome. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). Colocalizes with ZFP36 in the cytoplasm (PubMed:20221403). {ECO:0000250|UniProtKB:Q8R550, ECO:0000269|PubMed:20221403}.
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- B-cell linker protein
- Polyubiquitin-C
- E3 ubiquitin-protein ligase CBL-B
- Epidermal growth factor receptor
- Ubiquitin-ribosomal protein eS31 fusion protein
- Growth factor receptor-bound protein 2
- Ubiquitin-ribosomal protein eL40 fusion protein
- Polyubiquitin-B
- Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Sequence:
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK