wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphatidylinositol 4-kinase stt4 (PI4-kinase) (PtdIns-4-kinase) (EC 2.7.1.67) (Q9USR3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative cargo-transport protein ypp1
- Phosphatidylinositol 4-kinase lsb6
- Phosphatidylinositol 4-phosphate 5-kinase its3
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphatidylinositol 4-kinase pik1
- Uncharacterized protein C3C7.01c
- 1-phosphatidylinositol 3-phosphate 5-kinase fab1
- Uncharacterized protein C19F5.03
- Protein efr3
- Inositol-1,4,5-trisphosphate 5-phosphatase 1
Sequence:
MDCIDKSIRRESLRKLGCLPDHGWNLFVQSSNRYSKLLEADSKLFKAQRIEDTVLSICEVTLENKASENALTLFQQLRFYLLNYLFLEDTSEYKSVLCSLDESVYPNLLPLTANICPCILKALLALVRQHRELSSDIVKFLNSIFLALTRILNTPHSSNNNPTHTKTTIFEKVFYASHLGFFFEEIADACISALPQDACLWAMEVCNTILVSDLPCKLIDLHNDSFLHHSNYYAGFGLSYYLYLSSMKAYINSSGCLWYEDATSFWDIVKHRPSSPEEKPFLTQFQSILNLSDKFLSKTGTLRLQEKLGTSCNLFFVLVLKLALLSSSYIGFVPYTYSDWINVLLGSISEDPELLPHLIELMASLACVFPTHFQFAMKRLRLIAIYAPRFDDGNVTYAQLASRKLAQLFNYSSRDTAITSIYQFANLLSPADTPDSYLAAPKERLSISDNMSSSSSQTATVNTISNYLNVIDSVREIALTVNDEKIYGLAISLLIQKFSRKFDSRVSTELVRTLADISTKANDRDFSILVQFYSIQNKMLVKNGDEALTIAICDSRCLIARGTESNSFKRSDLLKSLLEEIIHIGIVRDTPAPELKGYYFGMSKAVQALVECVAGTDWSSLPKEEMYPALFRDMWFTLVINRFRYSVDLGETLEVDLENIAKNSPLLVFEDFGSNFESNLELNTVLRTHIEHSVISQIKSELLVRVPNIDLKPLSTSEICFLSAVLLLESLRCKSNKLSALVEYLLDPSLRDSQLPQSIRAIALYNLTSFVESLSKERRVASSTIDEFQKLLCLCCNRVDCVRQLALECMNYIMETLPHLLGIKEILFSVLELSSLLWKARTEECTDQYVPQLLYKSNKLNLSVILSDIYSCREEVLFQFNRHARSWIQNSSKAIPYQVKNLLESYLADFVDFDDLEVVELGRSLAVELGTRIVSSDRDNFVLPAFGNWTPDTSSEFMAEYTIRQRYSHVDNSILNIEGDMSTDRIDLILNEKSKLFETHLAALKSLEDDILQGNTVSPQRLRNEVRKAAAHAVQEPIFQFSVLARKIVRIPFLDFSPSSFKLGITLWNWMMNQVPSFSSFLISNIIRNWKNEIVTEKRGYFSTAKSKSPLALPMTYSPTERASFLSYKNKVMSQMIPHLLLLQLIAGNFEGFWYGDRQTAKLIVHFMKFVLKKITSMEVNLNVLTRELHFKFVSFGLRIAENLLNSPLGSRFYNLCVDAGLCWFSGMPNWTYGADKLHVAAEISVMRSLRDKLDSFLLRYPLKVSTTLKQKLLIILLNNEMYMLYTWLTPVLHGRNVRMVEPIPDSDAASSPITLEMLQVAWNVSPNIVLYAPKRFQNAPLKQMALNFVIANPFTSVKHEVALEYLFEHYPSGEFPIDRKFILYWEPMYPVSGPVMFMPNVKWNPQLLQYTMRSMESYPVSVTFFYVPQIVQSLRYDSMGYAESFILETSGTSQLFAHQILWNMKANLYKDEAATVPDSIKPILDRVMDKMINSLSGEDKQFYEREFTFFNEVTSISGKLKPFIRKSKPEKKAKIDEEMKKIKLDVGVYLPSNPDGVIVGIDRKSGKPLQSHAKAPFMATFKIRKEKLVDADPEELAVNGTEEEAGDSAKKQTYEVWQSAIFKVGDDCRQDVLTLQLIAMFKNIFNSVGLDVYLFPYRVTATNPGCGVIDVLPNCISRDMLGREAVNGLYDYFRTKFGDEDSIAFQKARSNFVQSMAAYSVITYLLQFKDRHNGNIMIDDQGHILHIDFGFIFDIAPGGITFESAPFKLTTEMIAVMGGSNKSQPFQWFQELCVKAFLACRPYAHYICQAVEVMLDSGLPCFKGQLTITHCLERFALNLNERQASTFMLHLIEQSYANKRTLMYDQFQKATNGIPY
Protein: ATP-dependent Clp protease, ATP-binding subunit ClpC (Q1D2Y0)
Organism: Myxococcus xanthus (strain DK1622)
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit 2
- ATP-dependent Clp protease adapter protein ClpS
- ATP-dependent Clp protease proteolytic subunit 1
- TssC1 N-terminal domain-containing protein
- ATP-dependent protease ATPase subunit HslU
Sequence:
MANVCDLCHQRPATTRVTRVMGNRRTTESLCDVCSSQRSRFGRMGLGTSLFDQFFSDFGDEDFGGLSRSLQQPVERYDITEAFSDETRRVLEAAFEAARSAGAASIDTEHLLVALAKDPLGRTALSRMKLDPARVAERAESEMRRGKRPMERPELSPHAKRALELAYQEAYELGHSYVGPEHVLLGLLHEGEGLASEILREQGAQHGKARAAVAEALAPSSEARRSPTPTLDEYCRDLTSLASEGKLDPVVGRANEIETTLEILSRRTKNNPVLIGEPGVGKTAIVEGIAQRIISAAVPDTLRDKRVLQLDLSGLLAGSKYRGEFEERLKKVMDEVKSHSEDIVLFIDEIHTIVGAGAAEGAMDAGNMLKPSLARGELHVIGATTLDEYRKRIEKDAALERRFQPVVVPEPTAEQAIEILRGLKDRYESHHRVRIADEALVAAVELSDRYVTGRFLPDKAIDLVDQAAARVRLRLTLPPERLVNAEHEVVKVKRSLDEARGRKAGPRIQELESKLNAAEREVQSAQKERRTQKSGETPEVRAEDVAEVLSRMTGIPVTQMTEDERKKLLELESRLHERVIGQDEAIRVLSQAIRRARAGLKDESRPIGSFLFLGPTGVGKTELAKTLAELLFGDEKALIRFDMSEYMEKHTVSRLVGAPPGYVGYEEGGQLTEAVRRRPYSVLLFDEVEKAHPDVFHMLLQVLDDGRLTDAQGTVVNFKNTVIIGTSNLGSHLIQESTARKEPQERMRERVMGVLKGHFPPEFLNRIDETVVFEPLNRAQLRAIVDLMLEKTRRLLHGQGIDLEVTPAALEALVDKGWDPTFGARPLRREIQRAIEAPLAEKLISGDIHENSRVRADFKDGKFRFDEVEAAEAEVAQAEASAVH
Protein: Dynein axonemal assembly factor 11 (DNAAF11) (Leucine-rich repeat-containing protein 6) (Leucine-rich testis-specific protein) (Protein tilB homolog) (Testis-specific leucine-rich repeat protein) (Q86X45)
Organism: Homo sapiens (Human)
Function: Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia. Acts as a crucial component in the formation and motility of spermatozoal flagella.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23122589, ECO:0000269|PubMed:23527195, ECO:0000269|PubMed:33403504}. Cell projection, cilium {ECO:0000269|PubMed:23122589}. Dynein axonemal particle {ECO:0000250|UniProtKB:A0A1L8G016}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:33403504}.
Interaction partners:
- Zinc finger MYND domain-containing protein 10
- Dynein axonemal assembly factor 3
- Dynein axonemal intermediate chain 1
- Dynein axonemal assembly factor 6
- Dynein axonemal assembly factor 5
- Dynein axonemal assembly factor 19
- Coiled-coil domain-containing protein 39
- Dynein axonemal assembly factor 4
- Coiled-coil domain-containing protein 40
- Sperm-associated antigen 1
Sequence:
MGWITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALNVNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVDVQPTYVRVMIKGKPFQLVLPAEVKPDSSSAKRSQTTGHLVICMPKVGEVITGGQRAFKSMKTTSDRSREQTNTRSKHMEKLEVDPSKHSFPDVTNIVQEKKHTPRRRPEPKIIPSEEDPTFEDNPEVPPLI
Protein: Autophagy-related protein 18a (AtATG18a) (Protein PEROXISOME UNUSUAL POSITIONING 2) (Q93VB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21395886}. Nucleus {ECO:0000269|PubMed:21395886}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Peripheral membrane protein of pre-autophagosomal structure (PAS) and vacuole. {ECO:0000250}.
Interaction partners:
- Probable WRKY transcription factor 33
- Autophagy-related protein 2
- Autophagy-related protein 9
- Ubiquitin-like modifier-activating enzyme atg7
- Ubiquitin-like-conjugating enzyme ATG10
- Autophagy-related protein 3
- Autophagy protein 5
- Autophagy-related protein 101
- Beclin-1-like protein
- Cysteine protease ATG4a
Sequence:
MATVSSSSWPNPNPNPDSTSASDSDSTFPSHRDRVDEPDSLDSFSSMSLNSDEPNQTSNQSPLSPPTPNLPVMPPPSVLHLSFNQDHACFAVGTDRGFRILNCDPFREIFRRDFDRGGGVAVVEMLFRCNILALVGGGPDPQYPPNKVMIWDDHQGRCIGELSFRSDVRSVRLRRDRIIVVLEQKIFVYNFSDLKLMHQIETIANPKGLCAVSQGVGSMVLVCPGLQKGQVRIEHYASKRTKFVMAHDSRIACFALTQDGHLLATASSKGTLVRIFNTVDGTLRQEVRRGADRAEIYSLAFSSNAQWLAVSSDKGTVHVFGLKVNSGSQVKDSSRIAPDATPSSPSSSLSLFKGVLPRYFSSEWSVAQFRLVEGTQYIAAFGHQKNTVVILGMDGSFYRCQFDPVNGGEMSQLEYHNCLKPPSVF
Protein: Nuclear migration protein JNM1 (P36224)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. JNM1 is associated with the rod and links it to the projecting sidearm. Required for proper nuclear migration during the mitotic cell cycle and for astral microtubule development.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Protein LDB18
- Protein NIP100
- Centractin
- Dynein heavy chain, cytoplasmic
- Actin-like protein ARP10
- WD repeat-containing protein PAC11
- Nuclear migration protein NUM1
- Nuclear distribution protein PAC1
- Karyogamy protein KAR9
- Endoplasmic reticulum membrane protein complex subunit 10
Sequence:
MNVIDLSDPAINVDYDSLIGIDNEESQEIFENEVKEDGQQEEQEEASSRKDGLIVEPGRDVESLRRAIRDQLLFKIHRQNQSDCADARKLSNDEEDESRQQKLERIREELEELKIENLTSEMQTEIKELCEIQSKLATESSSRLTNLRKKLLETYEGQDTVILPNIILDTSNIKRLQKLDQKISLMERFVGIPEALEAEEDRKSVHSKVNELYRSIQLLQGDDKAEGKLQKFRDRLVELNEEFENSLLGKKIQQDLRLKDDTVSKLVMPENKVKEINSMYSMFKQYQDSLPLLAERMKSLNKMNNRVIEVYETTKGLDSQITSIQEQGKVWLKALNELDKKFDEQEVKIRENMEQIRRKIDTLEDEALQRNSK
Protein: Neuralized E3 ubiquitin protein ligase 1 (A0A096MJM7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- E3 ubiquitin-protein ligase MIB2
Sequence:
MGGQITRNTLHDSIGSSFPVPSHRCHHKQKHCPPALSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRCEADEARLSVSLCDLNVPGADGEDGAPPAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARLEHGRDERALVFTSRPVRVAETIFIKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAPAGMQLCVDASQPLWMLFSLHGAITQVRILGSTIMAERGGPSLPCSPASTPTSPSALGSRLSDPLLSTCGSGPLGGSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYSCGLRLKKALHACCPICRRPIKDIIKTYRSS
Protein: CMP-sialic acid transporter 4 (CMP-SA-Tr 4) (CMP-Sia-Tr 4) (F4JN00)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sugar transporter involved in the transport of CMP-sialic acid from the cytoplasm into the Golgi (By similarity). Essential protein.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MEYRKIKDEDDHDVASDIESVKGKSHTVASSNIAMATLGVGSSERINWKRKGVVTCALTILTSSQAILIVWSKRAGKYEYSVTTANFLVGTLKCALSLLALTRIWKNEGVTDDNRLSTTFDEVKVFPIPAALYLFKNLLQYYIFAYVDAPGYQILKNLNIISTGVLYRIILKRKLSEIQWAGFILLCCGCTTAQLNSNSDRVLQTSLPGWTMAIVMALLSGFAGVYTEAIIKKRPSRNINVQNFWLYVFGMAFNAVAIVIQDFDAVANKGFFHGYSFITLLMILNHALSGIAVSMVMKYADNIVKVYSTSVAMLLTAVVSVFLFNFHLSLAFFLGSTVVSVSVYLHSAGKLR
Protein: Lamin (Q90XD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}. Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
METPGQKRSSRGGVTNVLSPTRISRLQEKEDLSNLNDRLAVYIDKVRSLEVENAGLRMRITESETEISRELSGMKAAYEAELADARKTLDSVAKERARLQLELSKVREDYKELKARNGKKEADLESALARLKDLESLLNSKDASLSTALGEKRTLEVEVRDLKAQLAKLEGSLNDAKKQLQDEMLRRVDAENRIQTLKEELEFQKNIYSEELRESKRRYESRVVEIDSGRQQDYESKLADALTDLRNQHEEQLRIYKEEIEKTYNSKLENARSSAERNSHLVGAAHEELQQTRVRMEGVSSQLSQLQKQLAAREAKIRELEEALSRERDILRRRLEDKEKEMAEMRQRMQQQLDEYQELLDIKLALDMEISAYRKLLEGEEERLRLSPSPPPARGVTVTRSSGSGSHTRVVQSSTSRTSSGSAKKRRLNDNDSDASSVVGGTVTRTRIFQQASASGRVTVDEVDLEGKFVRLNNKSDQDQSLGHWQVKRQIGSGTPIVYKFPPKFNLKAGQTVTIWAAGAGGTHSPPSDLVWKTQNSWGSGDLFQTTLISSSGEEMAMRKVTRTLFQDEEDDEMAAHSTCGDSEYNLRSRTVLCGSCGQPSDRNSSCVSASSGVSSASRSFSSGGGGGLTEAFVSPSHFIVSNDKPRQAGPKVDNCSIM
Protein: Alpha-ketoglutarate-dependent sulfonate dioxygenase (EC 1.14.11.-) (Q12358)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as an alpha-ketoglutarate-dependent dioxygenase active on sulfonates. Although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate.
Interaction partners:
- Uncharacterized transporter YIL166C
- High affinity cysteine transporter
- Homocysteine/cysteine synthase
- Putative uncharacterized protein YLL059C
- General amino acid permease AGP3
- Glutaredoxin-8
- Putative uncharacterized transporter YOL163W
Sequence:
MSPAAAQTAIPLPSTDLPVKIITNGLKNLNYTSKQGYGNFDTHFYDGQDEVSPSGLLKIRKSYREKSKYPDYLPTWDPTEKYGPLEFHEYHDPALRADGNFSNLFAKENVGQLKVKKITPKLGLEINGIQLTDLSDAAKDELALLVAQKGVVVFRNQNFADEGPDYVTEYGRHFGKLHIHQTSGHPQNNPELHITFRRPDAEEFARVFDDSTSSGGWHTDVSYELQPPSYTFFSVVEGPDGGGDTLFADTIEAFDRLSKPLQDFLSTLHVIHSSKEQAENSQRQGGIKRRAPVTHIHPLVRVHPVLKKKCLYVNRAFSRKIVELKRQESESLLNFLYNLVESSHDLQLRAKWEPHSVVIWDNRRVQHSAVIDWEEPIHRHAFRITPQAERPVEDLKFLNDENYYPSSLTLDI
Protein: DNA helicase (EC 3.6.4.12) (A0A0R4IR86)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Progestin and adipoQ receptor family member 3b
- DEP domain-containing 5, GATOR1 subcomplex subunit.
- SUMO-interacting motif-containing protein 1
Sequence:
MMKNKSKKQEDEGSTQSNASSNSASEESNRSGSESGSQSESEQGSEKAQSRHSESNSTSDSESHSESGSESNGSKSHQSSAQVKDKPVRKKDNLADVKKMWEEHPDVYGVRRSSRSRQEPARLNIGAEGSSDSEGESSKRKSSRQKKKENTWKDDDSNDEEDVEEETSSSESEQEEKKVRSRRLPARRPQTKSSASKQSQKGRKQRKQESSDEDDDDDDDDEEDTPKRQTRRRAATKVSYKEDQNDFETDSDDLIEMAEGAEEQQDDDSETIEKVVDTRTGKKGATGASTTLYAIEENGDPGADFDPEKEEGETQFLIKWKGWSYIHNTWESVDSLTQQKVKGMKKLENFKKKNEELNAWLKKASPEDLEYYNCQQELTNDLSKQFQIIERVIAHKSSSGEPEYLCKWMGLPYAECTWEDSALIKKKFQACIDSFHNRNSSKTVPSKDCKVLKQRPRFVPLKKQPSYIGDENLELRDYQLDGVNWLAHSWCRCNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFIVVVPLSTLTSWQREFDTWAPDMNVVVYLGDVTSRKTIRDYEWINPQTKRIKFNALLTTYEILLKDKGVLGNINWAFLGVDEAHRLKNDDSLLYKTLIDFRSNHRLLITGTPLQNSLKELWSLLHFLMSDKFESWEDFEDEHGKGRDNGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVDMSAQQKQFYKWILTRNFKALSKGTRGSSSGFLNIVMELKKCCNHAFLIKQPEDGENDAPQEHLQSLVRGGGKLVLLDKLLTRLKDRGNRVLIFSQMVRMLDILADYLSMKRYQFQRLDGSIKGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGTVEEDIIERAKKKMVLDHLVIQRMDTTGRTVLDNSSANSNSNPFNKEELSAILKFGAEDLFKEAEGEESEPQEMDIDEILRLAETRESDQGSSATDELLSQFKVANFTMDESTPDLDEKPGRDWDEIIPEEQRRKVEEEQKQKEMEDIYMLPRSRSSNKKAQANDSDSDVGSKLKHRSSGSDSETDDSEDDKRPKRRGRPRARKNNVEGFTDAEIRRFIKAYKKFGAPLERLEAIARDSELVEKSIADLKRLGELVHNSCVTAVQEHEEHLKENPVEAKGPGKRRGINIKISGVQVNAKSIIQHEEEFEPLHKAVPSNPAERNKFQLTCRVKTPHFDVDWDIHDDTQLLLGIYEHGYGNWDLIKTDPDLKLSEKILLDDPEKKPQGKQLQMRTDYLLKMLKKDLESQDAIKAGDEPKIKKRKPRMKKKAPSNELVNEIASPRLSDNPSEEGEVKDDGAEKTPTKKKQKKDNKENKEKTGTPKKEKEGDKDKKRSKPKKEKAKPAGKGKKAQGPVHITQGSEPIPIGEEDDELDQETFSICKERMRPVKKALKQLDKPDEGLSVQDQLQHTRTCLLKIGDRITECLKSYSDPEHIKIWRRNLWIFVSKFTEFGAQKLHRLYKKAQKKRSQEGEKEHKKKDDPIKKKPFRPEPSGSSRDSTGAQPTTKPHPPVSHQSGPPHPPHHREQYNQHNKRHFPNDDRGDWQRDRKYGYPGNSNQPWQGDRHHPYEPHRYKDHHYSDRRPHGDYRSSGGYRNSGSPRKRPYDQYGNDRDHRGHRDYYDRHPDPKRRRSDEYRSPNYHQGGGGGGGGGGGGGHPQDFRRMPDHRGPPGNHGPMGPDHYRPFHPDKPPPLIDPRSPQSQKSPLEPISPGMDRSAEQKSATDFNWNNRKT
Protein: Nibrin (Q9VT40)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
Interaction partners:
- DNA repair protein RAD50
- Double-strand break repair protein
- Serine/threonine-protein kinase ATM
- Serine/threonine-protein kinase ATR
- Microcephalin, isoform D
- DNA repair protein Rad51 homolog
- Regulator of telomere elongation helicase 1 homolog
- PAX-interacting protein 1
- Importin subunit alpha
- Uncharacterized protein, isoform B
Sequence:
MFVLTKDDEKFVLFPGKKVYTIGRLATDLIVAQDLSISRNHAQLLIQTEADGDDTLHIEDLGSRYGTFIFPKNSQKPRKVPAKTSTPLPVGTRLRFGANMSIWQVTQLKLVTTVSALTRSEVQELTKMLEPMGGTVTSNWTEECSHLTMNEVSVTVKLLHAMLENKPIVTFPYWRKMLQAAQSIHVKEGWPQPEDYQPTNIDVTWRPERTRLFAGKTFVFMNRKHFDMYGSVVQKAGATCKDINSGVRKTFLTKSDVIVIQYVPSSQSQATESINSIQDRYILEQNGRRIIQEYEIGMALIHCSITEFCNPTHKFISDSLPTTESVTSSMAFNSSIIVPNTERHSAQSNATPISELVVPESIECEMEQDASKPHSEDQASLRKRSHASTVDSSDEEKKSTLSKRAKSDIATKLTMKSKNAILLDSSLEEDVTPAPAPAPVQRVTRQSKAIAEEKSVHPPVPAASKHITRKTKQVFCVDSSDEENENARKPKETPAPTIPSMAKKKTEAPVATRISPRLNGKSLATNITNQPADKHAVPAKRPVLSVASSDEEDEGDLFQFRKSPQKPAETVVQPRIAGKGNAPARISVVDFLEKSQAQEPAPVPPQLESQSQTQPRKRLRLELLNESDSDDCDNLFNFADSKKKRKTQEAQRNDDSTDGLFNFNSERPSDHDDEDSRLTEPFVPETESKKQSKYIVAPRRDRPKKVDISGWLSCSRLNDNIKSEIDADSVKMETSIKADPDEEQWLAAMKDSIEVRMCNLNIVIRSQEEVDASLEDSVNKHGGRKNFKKFVKTKNPHPQKRIVALKSLRLADGMVTCV
Protein: Angiopoietin-2 (ANG-2) (O35608)
Organism: Mus musculus (Mouse)
Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). Involved in the regulation of lymphangiogenesis.
Subcellular location: Secreted {ECO:0000250|UniProtKB:O15123}.
Interaction partners:
- Angiopoietin-1 receptor
- Tyrosine-protein kinase receptor Tie-1
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor receptor 3
- Angiopoietin-1
- Angiopoietin-4
- von Willebrand factor
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor receptor beta
Sequence:
MWQIIFLTFGWDLVLASAYSNFRKSVDSTGRRQYQVQNGPCSYTFLLPETDSCRSSSSPYMSNAVQRDAPLDYDDSVQRLQVLENILENNTQWLMKLENYIQDNMKKEMVEIQQNVVQNQTAVMIEIGTSLLNQTAAQTRKLTDVEAQVLNQTTRLELQLLQHSISTNKLEKQILDQTSEINKLQNKNSFLEQKVLDMEGKHSEQLQSMKEQKDELQVLVSKQSSVIDELEKKLVTATVNNSLLQKQQHDLMETVNSLLTMMSSPNSKSSVAIRKEEQTTFRDCAEIFKSGLTTSGIYTLTFPNSTEEIKAYCDMDVGGGGWTVIQHREDGSVDFQRTWKEYKEGFGSPLGEYWLGNEFVSQLTGQHRYVLKIQLKDWEGNEAHSLYDHFYLAGEESNYRIHLTGLTGTAGKISSISQPGSDFSTKDSDNDKCICKCSQMLSGGWWFDACGPSNLNGQYYPQKQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF
Protein: Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein) (Q9BXL5)
Organism: Homo sapiens (Human)
Function: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
Subcellular location: Nucleus {ECO:0000269|PubMed:14730214}.
Interaction partners:
- Glycophorin-A
- tRNA
- Protein 4.2
- Alpha-hemoglobin-stabilizing protein
- Glycophorin-B
Sequence:
MDLGKDQSHLKHHQTPDPHQEENHSPEVIGTWSLRNRELLRKRKAEVHEKETSQWLFGEQKKRKQQRTGKGNRRGRKRQQNTELKVEPQPQIEKEIVEKALAPIEKKTEPPGSITKVFPSVASPQKVVPEEHFSEICQESNIYQENFSEYQEIAVQNHSSETCQHVSEPEDLSPKMYQEISVLQDNSSKICQDMKEPEDNSPNTCQVISVIQDHPFKMYQDMAKREDLAPKMCQEAAVPKILPCPTSEDTADLAGCSLQAYPKPDVPKGYILDTDQNPAEPEEYNETDQGIAETEGLFPKIQEIAEPKDLSTKTHQESAEPKYLPHKTCNEIIVPKAPSHKTIQETPHSEDYSIEINQETPGSEKYSPETYQEIPGLEEYSPEIYQETSQLEEYSPEIYQETPGPEDLSTETYKNKDVPKECFPEPHQETGGPQGQDPKAHQEDAKDAYTFPQEMKEKPKEEPGIPAILNESHPENDVYSYVLF
Protein: Copper-transporting ATPase PAA1, chloroplastic (EC 7.2.2.8) (Protein HEAVY METAL ATPASE 6) (Protein glucose insensitive root 1) (Q9SZC9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates copper transfer across the plastid envelope. Required for the delivery of copper into the plastid stroma, which is essential for the function of copper proteins. Seems to be selective for monovalent copper Cu(+) transport. Also plays a role in glucose signaling-mediated cell proliferation of root meristem in non-green tissues.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:12782727, ECO:0000269|PubMed:15772282}; Multi-pass membrane protein {ECO:0000269|PubMed:12782727, ECO:0000269|PubMed:15772282}.
Interaction partners:
- Copper chaperone for superoxide dismutase, chloroplastic/cytosolic
- Copper transport protein CCH
- Copper transporter 4
- Copper transporter 5
- Copper transport protein ATX1
Sequence:
MESTLSAFSTVKATAMARSSGGPSLPLLTISKALNRHFTGARHLHPLLLARCSPSVRRLGGFHGSRFTSSNSALRSLGAAVLPVIRHRLECLSSSSPSFRSISSGGGSGFGGYNGGSGGGGGGGSESGDSKSKLGANASDGVSVPSSDIIILDVGGMTCGGCSASVKKILESQPQVASASVNLTTETAIVWPVPEAKSVPDWQKSLGETLANHLTNCGFQSTPRDLVTENFFKVFETKTKDKQARLKESGRELAVSWALCAVCLVGHLTHFLGVNAPWIHAIHSTGFHVSLCLITLLGPGRKLVLDGIKSLLKGSPNMNTLVGLGALSSFSVSSLAAMIPKLGWKTFFEEPVMLIAFVLLGRNLEQRAKIKATSDMTGLLSVLPSKARLLLDGDLQNSTVEVPCNSLSVGDLVVILPGDRVPADGVVKSGRSTIDESSFTGEPLPVTKESGSQVAAGSINLNGTLTVEVHRSGGETAVGDIIRLVEEAQSREAPVQQLVDKVAGRFTYGVMALSAATFTFWNLFGAHVLPSALHNGSPMSLALQLSCSVLVVACPCALGLATPTAMLVGTSLGARRGLLLRGGDILEKFSLVDTVVFDKTGTLTKGHPVVTEVIIPENPRHNLNDTWSEVEVLMLAAAVESNTTHPVGKAIVKAARARNCQTMKAEDGTFTEEPGSGAVAIVNNKRVTVGTLEWVKRHGATGNSLLALEEHEINNQSVVYIGVDNTLAAVIRFEDKVREDAAQVVENLTRQGIDVYMLSGDKRNAANYVASVVGINHERVIAGVKPAEKKNFINELQKNKKIVAMVGDGINDAAALASSNVGVAMGGGAGAASEVSPVVLMGNRLTQLLDAMELSRQTMKTVKQNLWWAFGYNIVGIPIAAGVLLPLTGTMLTPSMAGALMGVSSLGVMTNSLLLRYRFFSNRNDKNVKPEPKEGTKQPHENTRWKQSS
Protein: Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) (O88480)
Organism: Rattus norvegicus (Rat)
Function: May be required for replication-independent chromatin assembly (By similarity). May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:9660798}.
Interaction partners:
- Ubinuclein 1
- Protein HIRA
- Anti-silencing function 1A histone chaperone
- Myocyte enhancer factor 2B
- Myocyte-specific enhancer factor 2C
- Ubinuclein-2
- Myocyte-specific enhancer factor 2D
- Protein HIRA
- Cellular tumor antigen p53
Sequence:
MIRIAALNASSTIEDDHEGSFKSHKIQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEARLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCDMSVHEVSVNAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFFTWKCLGESLLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQLLAPSIVVTPVSVVQPSPVCTNPTVAVAEPVLSYTSVTTTSFPLHSPGLLDTGTPMGDVSGGDKSKKGVKRKKTLEESGETAKRRSARVRNTKCKKEEKVDFQGLLVKFLPSRLRKLDPEEEDDPFNNYEVQSEAKLESFSNVGPHRLSFDSATFMESEKQDVHAFLMENLTNGGVLELMMRYLKSMGHKFLLKWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKDMMLMSLSCMELQLDQWLLTKGRSSTVSPRNCPAGVVTGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQGDMEQALENYDICTEILQSSTALQAQAGAEQRDIVIRLPNLHNDSIVSLEEIDKNLKSLERCQSLEEIQRLFEAGDYKAVVQLLRPTLCTSGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLEEHRQCFECSDVALNEAVQQMLNSSDSAAKEEWAATVTQLLLGMEQALSSDSRGSILKESSSPTGLVRLTNNLIQVIDCSMAVQEEPKEPYVSSVLPWIILHRIIWQEEDTFRSLCHQQQLQNPTEEGISEMPMLPSSLMLLNTAHEYLGRRSWCCNSDGALLRFYVHVLQKELAASASEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVDLTWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTEKPALSMDKVSAYIEGTSAEVPCLPDGADPAPPVLNELYYLLADYHFKNKEQSKAIKFYMHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWRHATPVLNCFRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRAELPPEVVQQMEDRRDSMLETARHCFTSAAHCEGDGDEEEWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEALEVYFRLHASILKLLGKPDSGVSAEVLVSFMKEAAEGPFARGEEKNTPKASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPGLTSPPYTATPIDHDYVKCKKPRQQATPDDRSQDSTAVALSDSSSTQDFFNEPTSLLDGSRKLLPEKRISGLSAQAGPSGKDLPGPTEERGKTEESLESTEAFRVVEPSVQKPVADSSASAYIPSKPAVSTPPPWDGKKRSDPLGEPVAFPQGLPAGAEEQRQFLTEQCIASFCLCLSRFPQHYKSLYRLAFLYTYSKTHRNLQWARDVLLGSSIPWQQLQHMPAQGLFCERNKTNFFNGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTLSELAEGLEHPGSKACGLSGARMTTDVSHKASPEDGQESLPHPKKLPLADGSGPGPEPGGKVGPLHQLPVATDTRDNTEQGGEPKDKERPPVGPTEPMDTGETAARHPDLEPTPRLLPGRPPRDRGPESRSAELSLEELSISTRQQPAPLVPSPVTPTTAAPTTMGARAAGHPEEAPPRPNRKRKLLQDTESGKTLLLDAYRVWQQGQKAMAYDLSRIEKIMSETYMLIKQVDEETALEQAVKFCQVHLGAAAQRQASGDAPTTPKHPKDSRENFFPATVAPSAPDTTAPDALQRPSDSHLKPGLAAAITCPPSASASTPDPGIPQPHRPEAVPSRAPLSPDGEEVSGVTEGPSFLSQEPRHSHQMKMAATGPLAEQHCWPVEAACQTGAEPTFSQATSTKVPSSGSTQTPESHQGKTESSRAKSRLLPNMPKLVIPSATTKFPPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESLCQPALEVLETSSQESSLESETDEDDDFMDV
Protein: IGF-II mRNA-binding protein, isoform L (IGF-II mRNA-binding protein, isoform M) (M9NF14)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RNA-binding protein squid
Sequence:
MASELDQFADLELSKEDREQIFDPPLDRQQLEGAGTSSVTTSKILISGIPMQTRFEDIEPLLKPYGIVKQCEAISSKDQNTQTVHITFENPEQAQRAAVGLNGVEFEGSKLHAEQLDKNQRRSQRNQRNPYPGMPGPGRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPENCTNACKRILEVMQQEAISTNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSINDINSFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMMSTPGNGMVFNTSMPFPSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAIIGTRGSHIRSIMRFSNASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQVGRIIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETPVHIIGLFYSVQSAQRRIRAMMLSTNPPPITKKQKAAKEQLQQQQQSLAGAASSGSQQQQPQSPSQQQALPPQLHHQPVSSASSSSTPPAHHQQQASTAATSHQLQQQQPSPPPPGNATAAAAQQQQQLASSQQ