wanglab/gogpt-training-data huggingface dataset:
Protein: Kinesin, putative (Q583P6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Kinesin-like protein, putative
- Kinesin-like protein
- Kinesin, putative
- Kinesin, putative
- Kinesin, putative
- Kinesin-like protein
- Kinesin-like protein
- Kinesin-like protein
- Kinesin, putative
- Kinesin, putative
Sequence:
MNVRVATAVRILPGTAIADKQFILSSVHKAVDGQTVVVDSCGDGSRPMIVRVDEVYDEEDNQSYFYEQAVRDLVCCAFDGSYCTVLAYGAAGSGKTYSVLGPKAQENIMEEAGIFLRVFEDLFRYQEKMSKRRHIMFFVAALELVGEQVLDLLKRRSKIPVSDVSSDYLLHNLRHAEVTSMTEATNVFNLINDMRQDLPTDGITRGSRSSALIFIDIVQVAHKHFPDRPTREKLVEVGGFSVEPSVRGILHSRVLLVDLVGSNIGRTSGIGGEEVIENLGMAKSLQTLGMCVRSLYVGDSHIPFCDAKLTELLKPSLAESTSRVLVVAHVSPLAKDGDETRETLCFCDRIKEFKADKSYNVPSAGFGEYETQPVTQHRELLADVRIAAAVAYYTPQRPYFTSMLKGVSVKEARDAAIVSLKNELDGLEMRKETEYISKAKEKIMKDRDKRVRGFASRMNQMIEEYEVISQKVKEEKKVSKHLTREYEAKSEEAITEAKKAKKSRLKAQEKVENLREQLGLPKVDSSLPNQESSQSHKYDDDKMFCGGSTEELSNEERERETLLDNLVNDFQTAAKDLNDVHATYAKRLTATQRQRAQVRRIKMLCSGIILDSTLVEDIIDFIIDRAVDISHKVIKPSQPYSWKNIEGLSTVLRGGNRLYPPLFNSIPDATKVDSTGVFHRCTFLSSDESDEENSHYPDETRRPVEMDNDLYEHYLAMGNTQKKVKEDGSAGSEKKSAAKWGGEISETARDEARKPAKENAEDGGVEGSPIGLNASATESLHLDGDNDGEFNQSDNNVEESEEPLTESEKQRMRTRRDQQYLMRVYDSPTLVDDLIKFLRGGTVMLKHGRIGKPHRRLFWVSIDREKRKLLWADPDATASRSSSYVDLDNVSYIQIGCFSKVFKRYCSTSTDPSFYRSFTVGLKDGSRTVDIVADTLADFEAWVLGLSNLVRVDPSWGGKLDVSVEVNYDRLNCFEVSLCETNYIFPTQYLMLKRRVTQIAAHTLEVLQQCGNDVAKAQEILNGIHPPGINDKGAVYLTKGELRFVGRNEIDIIRITKIWMLFQQMNLVYDDNFVPATTFGITRRS
Protein: Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Q04753)
Organism: Rattus norvegicus (Rat)
Function: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54105}. Nucleus {ECO:0000250|UniProtKB:P54105}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P54105}. Note=A small fraction is also associated with the cytoskeleton. {ECO:0000250|UniProtKB:P54105}.
Interaction partners:
- Protein arginine N-methyltransferase 5
- Small nuclear ribonucleoprotein Sm D1
- Methylosome protein WDR77
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein Sm D2
- Gem-associated protein 2
- Small nuclear ribonucleoprotein F
- U7 snRNA-associated Sm-like protein LSm10
- Survival motor neuron protein
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MSFLKSFPPPGSADGLRLQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHAVSRDPNAYPQEHLYVMVNARFGEESKEPFSDEDEDDNDDVEPISEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSVRTYEDGMEVETTPTVAGQFEDADVDH
Protein: S protein (Q91QT1)
Organism: Avian infectious bronchitis virus (strain Beaudette US) (IBV)
Subcellular location: Host endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000256|ARBA:ARBA00034689}. Virion membrane {ECO:0000256|ARBA:ARBA00004182}.
Interaction partners:
Sequence:
MLVTPLLLVTLLCALCSAVLYDSSSYVYYYQSAFRPPNGWHLQGGAYAVVNISSEFNNAGSSSGCTVGIIHGGRVVNASSIAMTAPSSGMAWSSSQFCTAHCNFSDTTVFVTHCYKHGGCPITGMLQQNLIRVSAMKNGQLFYNLTVSVAKYPTFRSFQCVNNLTSVYLNGDLVYTSNETIDVTSAGVYFKAGGPITYKVMREVKALAYFVNGTAQDVILCDGSPRGLLACQYNTGNFSDGFYPFTNSSLVKQKFIVYRENSVNTTCTLHNFIFHNETGANPNPSGVQNIQTYQTKTAQSGYYNFNFSFLSSFVYKESNFMYGSYHPSCKFRLETINNGLWFNSLTVSIAYGPLQGGCKQSVFKGRATCCYAYSYGGPSLCKGVYSGELDHNFECGLLVYVTKSGGSRIQTATEPPVITQNNYNNITLNTCVDYNIYGRTGQGFITNVTDSAVSYNYLADAGLAILDTSGSIDIFVVQGEYGLNYYKVNPCEDVNQQFVVSGGKLVGILTSRNETGSQLLENQFYIKITNGTRRFRRSITENVANCPYVSYGKFCIKPDGSIATIVPKQLEQFVAPLFNVTENVLIPNSFNLTVTDEYIQTRMDKVQINCLQYVCGSSLDCRKLFQQYRPVCDNILSVVNSVGQKEDMELLNFYSSTKPAGFNTPVLSNVSTGEFNISLLLTTPSSRRKRSLIEDLLFTSVESVGLPTNDAYKNCTAGPLGFFKDLACAREYNGLLVLPPIITAEMQAMYTSSLVASMAFGGITAAGAIPFATQLQARINHLGITQSLLLKNQEKIAASFNKAIGHMQEGFRSTSLALQQIQDVVSKQSAILTETMASLNKNFGAISSVIQEIYQQFDAIQANAQVDRLITGRLSSLSVLASAKQAEYIRVSQQRELATQKINECVKSQSIRYSFCGNGRHVLTIPQNAPNGIVFIHFSYTPDSFVNVTAIVGFCVKPANASQYAIVPANGRGIFIQVNGSYYITARDMYMPRAITAGDVVTLTSCQANYVSVNKTVITTFVDNDDFDFNDELSKWWNDTKHELPDFDKFNYTVPILDIDSEIDRIQGVIQGLNDSLIDLEKLSILKTYIKWPWYVWLAIAFATIIFILILGWVFFMTGCCGCCCGCFGIMPLMSKCGKKSSYYTTFDNDVVTEQYRPKKSV
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) (P21569)
Organism: Zea mays (Maize)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Cytoplasm.
Interaction partners:
- UPF0235 protein
- Elongation factor 1-alpha
- Nuclear pore complex protein NUP107
- Nuclear pore complex protein NUP88
- Cytochrome P450 monooxygenase
- Seh1-like protein
- Zinc finger CCCH domain-containing protein 4
- Elongation factor 1-alpha
- Elongation factor 1-alpha
- Elongation factor 1-alpha
Sequence:
MANPRVFFDMTVGGAPAGRIVMELYANEVPKTAENFRALCTGEKGVGKSGKPLHYKGSTFHRVIPEFMCQGGDFTRGNGTGGESIYGEKFPDEKFVRKQPAPGVLSMANAGPNTNGSQFFICTVATPWLDGKHVVFGQVVEGMDVVKAIEKVGTRNGSTSKVVKVADCGQLS
Protein: COP9 signalosome complex subunit 7 (Signalosome subunit 7) (Q55BD5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 1
- COP9 signalosome complex subunit 3
- Ubiquitin-like protein NEDD8
- Cullin-4
- Eukaryotic translation initiation factor 3 subunit F
Sequence:
MTTQQETLTDGNALKQFVVLAKSSKGRAIVSIIEKALNHPSVFVFGELLDMPNVQQLKETEFKNYYDLLLIFAYGSFIDYKNKKDSLPQLTPQMITKLKQLTIVFLSSTSNVIPYSVLQEQIEITNVRELEDLIIDSIYQNIIKGKLDQKNKHLEIDFSIGRDVQPEQLDSMINCLNNWSSTSQKLLDDISGLITHSDKVHLQYRKEKEEFESKFEIAKLNTKNDSPAEQLYYDSMEYSDEVRMKKGPKIKGKDYNKRP
Protein: Peptidase S54 rhomboid domain-containing protein (Q586M1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MIPTCIAIRLTPVWICLLVHFADGKWPTPFQCLARVQDYGFSVSAFKRNPLVLVTHMFVHASDEHFVGNVMLLLCTLLELGEDCFQIGVADRGMWKSIKEAAGATAVLIIGGVSGVAGQLLFDYAQLKWKRWKGMFSVKGLIGFFHEEEEGIFSTLKSQFDSWVGSVTYSVGKHRVDTSFMCGASAGGYAIHGFGAAYRGTWITVWMAAALEVFKLATATLGGKPTSGSSGTGWGWWWGPGETVGHAAHLGGLGAGVLMGLGWRWWREHRRRHRFRRTLYT
Protein: Mbd3 protein (B2RZ64)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
RPAGGGGPRDGTAAASGGGGEGNRAGDEPGGRDLQKRRRHRRRQARRRAESRGAMERKSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMNKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLSAFDIAEELVRTMDLPKGLQGVGPGCTDETLLSAIASALHTSTLPITGQLSAAVEKNPGVWLNTAQPLCKAFMVTDDDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEEEEEEEEEEEEEPEPERV
Protein: Lipoprotein inner membrane ABC-transporter (YbtP protein) (Q9R7V3)
Organism: Yersinia pestis
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Irp1 protein
- Putative signal transducer
- Previously sequenced as Yersinia pestis yersiniabactin biosynthetic protein Irp2 TR:Q9Z399
- YbtA
- YbtQ
- Previously sequenced as Yersinia pestis yersiniabactin biosynthetic protein YbtU TR:Q9Z3C6
- Salicylate synthetase
- Pesticin receptor
- YbtT protein
- Salicyl-AMP ligase YbtE
Sequence:
MSSQSSNTESLSRFPLWQVITPVRRKVILAMALAGLAALTSLGALLFLAWSLRDIRATPDAIPAWPLGGVIGCVVLTFVLRLQAFNTSHYAAFHLENILRSRLARKALQLPPGVLQQMGSGSVAKVMLDDVKSLHIFVADSTPLYARAIIMPLATIVILFWLDWRLAIATLGVLAFGSVVLVLARQRSEDMAQRYHKAREQVSAAVIEFVQAMPVVRTFDSGSTSFLRYQRALEEWVDVLKTWYRKAGFSARFSFSILNPLPTLFVLIWSGYGLLHYGSFDFIAWVAVLLLGSGMAEAVMPMMMLNNLVAQTRLSIQRIYQVLAMPELSLPQSDQQPQEASITFEQVSFHYPQARTGAALQEVSFHVPAGQIVALVGPSGAGKSTVARLLLRYADPDKGHIRIGGVDLRDMQTDTLMKQLSFVFQDNFLFADTIANNIRLGAPDAPLEAVIAAARVAQAHDFISALPEGYNTRVGERGVFLSGGQRQRITIARALLQDRPILVLDEATAFADPENEAALIKALAAAMRGRTVIMVAHRLSMVTQADVILLFSDGQLREMGNHTQLLAQGGLYQRLWQHYQQAQHWVPGGTQEEVVENERQ
Protein: Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1) (Q9H2A9)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
- Beta-1,4-N-acetylgalactosaminyltransferase 3
- Carbohydrate sulfotransferase 9
- Carbonic anhydrase 6
- Glycoprotein hormones alpha chain
- Lutropin subunit beta
Sequence:
MTLRPGTMRLACMFSSILLFGAAGLLLFISLQDPTELAPQQVPGIKFNIRPRQPHHDLPPGGSQDGDLKEPTERVTRDLSSGAPRGRNLPAPDQPQPPLQRGTRLRLRQRRRRLLIKKMPAAATIPANSSDAPFIRPGPGTLDGRWVSLHRSQQERKRVMQEACAKYRASSSRRAVTPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTADIQHNTVHYGSALKRLDTFDRQGILHRLSTYTKMLFVREPFERLVSAFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVRFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDANFFLSLIRAPRNLTFPRFKDRHSQEARTTARIAHQYFAQLSALQRQRTYDFYYMDYLMFNYSKPFADLY
Protein: Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8) (O95907)
Organism: Homo sapiens (Human)
Function: Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity).
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:21199217}; Multi-pass membrane protein {ECO:0000255}. Note=Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (PubMed:21199217). Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (By similarity). {ECO:0000250|UniProtKB:O35308, ECO:0000269|PubMed:21199217}.
Interaction partners:
- Basigin
- Embigin
- Sialin
- Monocarboxylate transporter 2
Sequence:
MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV
Protein: Late transcription coactivator (Gene product 33) (gp33) (RNA polymerase-associated protein Gp33) (P13338)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Activates transcription at late promoters when the sliding clamp is present. Binds to both the host RNA polymerase (RNAP) and the upstream dsDNA.
Interaction partners:
Sequence:
MTQFSLNDIRPVDETGLSEKELSIKKEKDEIAKLLDRQENGFIIEKMVEEFGMSYLEATTAFLEENSIPETQFAKFIPSGIIEKIQSEAIDENLLRPSVVRCEKTNTLDFLL
Protein: Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) (Q9BYG5)
Organism: Homo sapiens (Human)
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Subcellular location: Cytoplasm. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
Interaction partners:
- Protein kinase C zeta type
- Cell division control protein 42 homolog
- Partitioning defective 3 homolog
- Protein kinase C iota type
- LLGL scribble cell polarity complex component 2
- Partitioning defective 6 homolog gamma
- Protein crumbs homolog 3
- Lethal
- Ras-related C3 botulinum toxin substrate 3
- Protein PALS1
Sequence:
MNRSHRHGAGSGCLGTMEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVDVLVGYADIHGDLLPINNDDNYHKAVSTANPLLRIFIQKKEEADYSAFGTDTLIKKKNVLTNVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSGQSTDNSLLGYPQQIEPSFEPEDEDSEEDDIIIEDNGVPQQIPKAVPNTESLESLTQIELSFESGQNGFIPSNEVSLAAIASSSNTEFETHAPDQKLLEEDGTIITL
Protein: Geranylgeranyl pyrophosphate synthase 9, chloroplastic (GGPP synthase 9) (GGPS9) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase 9) (Dimethylallyltranstransferase 9) (EC 2.5.1.1) (Farnesyl diphosphate synthase 9) (Farnesyltranstransferase 9) (EC 2.5.1.29) (Geranyltranstransferase 9) (EC 2.5.1.10) (Q9LUE1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Geranylgeranyl diphosphate reductase, chloroplastic
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- Phytoene synthase 1, chloroplastic
- Diphosphomevalonate decarboxylase MVD1, peroxisomal
- Diphosphomevalonate decarboxylase MVD2, peroxisomal
- Isopentenyl phosphate kinase
- Ent-copalyl diphosphate synthase, chloroplastic
- Farnesyl pyrophosphate synthase 1, mitochondrial
- Heterodimeric geranylgeranyl pyrophosphate synthase small subunit
- Isopentenyl-diphosphate Delta-isomerase II, chloroplastic
Sequence:
MATTVHLSSSSLFSQSRGRRDNSISSVKSLRKRTVLSLSSALTSQDAGHMIQPEGKSNDNNSAFDFKLYMIRKAESVNAALDVSVPLLKPLTIQEAVRYSLLAGGKRVRPLLCIAACELVGGDEATAMSAACAVEMIHTSSLIHDDLPCMDNADLRRGKPTNHKVYGEDMAVLAGDALLALAFEHMTVVSSGLVAPEKMIRAVVELARAIGTTGLVAGQMIDLASERLNPDKVGLEHLEFIHLHKTAALLEAAAVLGVIMGGGTEQEIEKLRKYARCIGLLFQVVDDILDVTKSTEELGKTAGKDVMAGKLTYPRLIGLEGSREVAEKLRREAEEQLLGFDPSKAAPLVALASYIACRHN
Protein: Mitochondrial inner membrane protein Mpv17 (Protein Mpv17) (Mpv-17) (P19258)
Organism: Mus musculus (Mouse)
Function: Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (By similarity). Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance. May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (Probable).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P39210}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P39210}.
Interaction partners:
- Mpv17-like protein 2
- Mpv17-like protein
- Deoxyguanosine kinase, mitochondrial
Sequence:
MALWRAYQRALAAHPWKVQVLTAGSLMGVGDMISQQLVERRGLQQHQAGRTLTMVSLGCGFVGPVVGGWYKVLDHLIPGTTKVHALKKMLLDQGGFAPCFLGCFLPLVGILNGMSAQDNWAKLKRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAIVWNSYLSWKAHQF
Protein: Loss of visual transmission (A0A0S0WGX2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Histidine decarboxylase
Sequence:
MDKLHDYQGIAGRFHQCRDNIKEFYEDYHSKKSTNLVDTVKKHLNGNTSANKDFSHVFRTKTRTELVRVSAAVMGIEFSYAAETAFVSPTLLKIGVEHQHMTLVWALSPLVGFFLCPILGSLSDRCKLNIGRRRPFILLLSIGVIFGLLLVPNGEALGYWLGDDNLQSLDMFSEINNLKNITSIYNSPSQSSHSWGIFFTVLGTVLLDFDADACQSPARAYLLDVCLPEDQARGLSTFTIMAGLGGFFGYSMGGVNWDETEIGRRLGGHVKAVFSIITIIFIACVTFTLTSFAEIPLWVLANTDTKNCGGETALSKSYGSCDSHDKTINCTDENKQVKTEDENPNISIAYRIVDETSFTENSEIIQENGCTQNGDSYNAQNTMEVESLSHYLLSIVYMPLSLKLICVTNLFCWMAHVCYSLYFTDFVGEAVFKGDPKATLGSLPQKRYEEGVRFGCWGMAMYSLSCSFYSLVIEYLIQRFRAKTVYVGGLLVYCIGMALMALTRAKLSVIVFSWTAGIMYSTLFTMPYLLVAHYHNVSTFELDNNGAAKLGSGLRGLGTDVAIISSMVFLAQFLLSLCMGTIIKISGTTTAVISTASFLSFCGALSATRIMYLDL
Protein: Membrane-associated progesterone receptor component 2 (Progesterone receptor membrane component 2) (Q7SZC7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Progestin and adipoQ receptor family member VII, a.
- Membrane progestin receptor alpha-B
- Cytochrome b5 type B
- Cytochrome b5
- Progesterone receptor.
- Membrane progestin receptor gamma-A
- La ribonucleoprotein 1B
- Achalasia, adrenocortical insufficiency, alacrimia
Sequence:
MADDGDGRSAVADTSGDQGTTEELDPGAGLGLGGMLLNLSVLVLVLAACYVLYARWWRRAGADLGRGSEASPLPKMRRRDFTLQQLRDYDGVQNPRILMAVNTKVFDVTSGKKFYGREGPYGIFAGRDASRGLATFCLEKDALRDEYDDLSDLNAVQMESVREWEMQFMEKYDYVGRLLKPGDEPSEYTDEEDMKDHQKHE
Protein: FHA domain-containing protein (Q3UUI2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
ELDAPAPQEVSSEFKKPVLPVPSAVRGKAPASSPSVSEDVKKECLAAQLDSGCEEPEVPPPQPDSQETGGPPVEQLRSPRVAPASGGPTRAPPYREPSWGSPATAPYSLETLKGGTILGTRTLKDTSCCFFGRLASCDICLEHPSVSRYHAVLQHRGADPSGDSEGHEQGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVMRFGGSTRLFILQGPEEDREAESELTVTQLKELRKQQQILLEKKMLGEDSDEEEEANTTEGKSSRSGQDDELGCTWGMGEDAVEDEAEENPIALDFQQDREAFYIKDPKKALQGFFDREGEELEYEFDEQGHSTWLCRVRLPVDDSTGKQLVAEAIHSGKKKEAMVQCSLEACRVLDTLGLLRQEAVSRKRKAKNWEDEDFYDSDDDTFLDRTGLVEKKRLNRMKKAEKLDEKPETFESLVAKLNDAERELAEISERLKASSKVLSEPSSQDSLDAFMSEMKSGSTLDGVSRKKLHLRTFELRKEQQRLKGLIKLVKPAEIPELKKTELQTTNA
Protein: Phosphopantothenoylcysteine synthetase, isoform C (EC 6.3.2.5) (E2QD26)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- pantothenate kinase
- Phosphopantothenoylcysteine decarboxylase
- 4'-phosphopantetheine phosphatase
- Bifunctional coenzyme A synthase
- FI04487p
- cystathionine gamma-lyase
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase
- Cysteine dioxygenase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
Sequence:
MTHWEDFYNTHLPPADFEDNRSLLKEFCERHNKLQNRIVLVTSGGTTVPLEHNTVRFVDNFSAGTRGSASAEYFLDHDYAVIFMHRHKSLEPFTRHFTGQQFFDMLDIADNSQSSTIAIKPDSVDVFAPVLAKYKIARETQMILYVNFTSVVDYMWLLRAACECLAAFEERAVLYLAAAVSDFYIPEDMMPTHKMQSGDGAPTISLQLVPKMLAPLASLWVPHAFVVSFKLETDESLLIVKARDSLNKYKHKLVIANVLQTRKHRVVFVTPTDSYELHLTREQTLQGLEIEEPIVADVVQKHGEFISNAQQRQXPLSMRRRPQTQHQQHHHQQLATGDEDEDGGDLDRDPYCVTSSHYCRVLNPGTPGFARKY
Protein: Stromal interaction molecule 1 (P70302)
Organism: Mus musculus (Mouse)
Function: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q13586}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q13586}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q13586}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q13586}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q13586}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q13586}. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular Ca(2+) and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Colocalizes with ORAI1 at the cell membrane. Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (By similarity). {ECO:0000250|UniProtKB:Q13586}.
Interaction partners:
- Short transient receptor potential channel 1
- Protein orai-3
- Protein orai-2
- Calcium release-activated calcium channel protein 1
- Stromal interaction molecule 2
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Short transient receptor potential channel 4
- Short transient receptor potential channel 5
- Short transient receptor potential channel 6
- Voltage-dependent L-type calcium channel subunit alpha-1C
Sequence:
MDVCARLALWLLWGLLLHQGQSLSHSHSEKNTGASSGATSEESTEAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVIQWLITYVELPQYEETFRKLQLTGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAERQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQLGLGSQRDLTHSDSESSLHMSDRQRVAPKPPQMGRAADEALNAMPSNGSHRLIEGVHPGSLVEKLPDSPALAKKTFMALNHGLDKAHSLMELNPSVPPGGSPLLDSSHSLSPSSPDPDTPSPVGDNRALQGSRNTRIPHLAGKKAMAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK
Protein: Probable protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Q0WVD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O60678}.
Interaction partners:
- Small ribosomal subunit protein uS5y/uS5u/uS5v
- Histone H4
- rRNA 2'-O-methyltransferase fibrillarin 2
- DEAD-box ATP-dependent RNA helicase 36
- Expressed protein
- E3 ubiquitin-protein ligase At3g02290
- Bystin
- E3 ubiquitin-protein ligase At4g11680
- rRNA biogenesis protein RRP5
Sequence:
MAATMVKHEILNYSEDEEENYSDEGDWGDWKADDNGIEGGEEEEEDDGDDSESDFLCLFCDSHFVSCDLLFEHCRLSHGFDFHGVRKELKLDFYSSFKLINYIRSQVAENMCFSWKIEADDYKDVKFPWDEEKYLKPFWQEDSLLYSFADDEEDEEVTFDREEVMEELQKLGDLSIDVEALGESSMSNSDKCNINGSKDVTSLSNCNGLKQSSADDLIVNGKDAEPKVCDGRLVNRNIRKVNENYFGSYSSFGIHREMLSDKVRTEAYRDALLKNPTLLNGSVVMDVGCGTGILSLFAAKAGASRVVAVEASEKMAKVATKIAKDNKVFNDNEHNGVLEVAHSMVEELDKSIQIQPHSVDVLVSEWMGYCLLYESMLSSVLYARDRWLKPGGAILPDTATMFVAGFGKGATSLPFWEDVYGFDMSSIGKEIHDDTTRLPIVDVIAERDLVTQPTLLQTFDLATMKPDEVDFTATATLEPTESEAKTRLCHGVVLWFDTGFTSRFCKENPTVLSTSPYTPPTHWAQTILTFQEPISVAPASVLSGNDRREAIGTEECPASSIHLRVSVARAHEHRSIDISLEATGLSSKGQKRHWPVQIFNL
Protein: All0195 protein (Q8Z0A3)
Organism: Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Interaction partners:
- DNA-directed RNA polymerase subunit alpha
Sequence:
MSIQVYGIPNCGTCKKTFNWLQAHKVDYEFINTKENPPTREHIQNWVKSLSSTPMRNTSGQSYRALGEEKKNWTDEQWIEEFAKDAMLLKRPLFVKDGIAVAVGFRDEKIIREKLGF