wanglab/gogpt-training-data huggingface dataset:
Protein: Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249) (Q07075)
Organism: Homo sapiens (Human)
Function: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10692253}; Single-pass type II membrane protein.
Interaction partners:
- T-cell surface glycoprotein CD4
- C-C chemokine receptor type 5
- Angiotensinogen
- C-X-C chemokine receptor type 4
- Inter-alpha-trypsin inhibitor heavy chain H4
- CD209 antigen
- Complement C4-A
- Dipeptidyl peptidase 4
- Complement C4-B
- Calmodulin-like protein 3
Sequence:
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
Protein: AT3g17020/K14A17_14 (Adenine nucleotide alpha hydrolases-like superfamily protein) (Q9LSP5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative RING zinc finger protein; 84572-85321
- Zinc finger CCCH domain-containing protein 24
- Oxysterol-binding protein-related protein 1D
- At5g58750
- tRNA wybutosine-synthesizing protein 2/3/4
- At4g25680
- At4g25660
- At1g21000/F9H16_1
- Putative RRM-containing protein family protein)
- 65-kDa microtubule-associated protein 6
Sequence:
MAESGGRRIGVAVDFSDCSKKALSWAIDNVVRDGDHLILITIAHDMNYEEGEMQLWETVGSPFIPMSEFSDAAVMKKYALKPDAETLDIVNTAARKKTITVVMKIYWGDPREKICAAAEQIPLSSLVMGNRGLGGLKRMIMGSVSNHVVNNVACPVTVVKAHI
Protein: Metabotropic glutamate receptor-like protein A (Q55AP1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May play an important role in the terminal differentiation.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cell cortex {ECO:0000269|PubMed:17950724}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17950724}.
Interaction partners:
Sequence:
MNKLKFLIILFITFLFNLKYINSLKQCKISVLLSGDWSDMGYNYQMNNARIKAESALNLEMSLCYKNLEVSIDLAKQAIEDSIKKGANFIVISSSVHTSIGYEYARLHRDKDIYWLIRGRGRPVPDDLPKVAVINFNTHLLHYTLGLVSGYLTTSGTVGFISPGPQILALANSNSFYLGALASRKNVTFLNAYTGSWYNPEVAYKASQMLISNGADFIGMSQDDMSVQKALMDSGKMALGITGFSNRLIWGSDIALSYITDWSDVFIKYAGHILNDTWPEYTDYYTTLAEGGSLLFDTFSYRVPSEVQKLVSLEIEKLKNSSYQPFRCNPMYSQINLNFDSNGCANDMEFKNTKLLLKGTDISKTINLGLYTIPIEFVDYSNSMKLGLTIVSGFCILFCIISMVLVIMFRHAKIIKSASPIFCLLILFGCIIIFSGCIIFSLSPTDGICGARVWLLSIGYTIFLGSLLVKNWRIWLLFDNPKLKKRSITNWKLYPFVAGILAADVLILALWQGLGDIRSESRIGIDSLTKYQYANVCSSNDQGSVALYILLVFHGIKLLAACFISFKIKAVDIEEFNESKPIASSIYIITFCLFIVIPLMVSPQSVASQVITIVVCAIVTTLISISLLFGSKFYMMATQGLALNQTFATNTKSSSFSLSLEKQKSKSNGLEFEDSDESEEKLPQIKNYSNSEIPNLQHNHSRLAHFSSDSCTSAEQDSKLDLENQNDENEIENNQNNQNNIVEDCQKVEKLEKDENLEKDENLEKDENLEKDNENQSIIQKKRLSKNFNQSEIDPDDV
Protein: Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavin mononucleotide kinase 1) (Flavokinase) (O74866)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
Interaction partners:
- Probable FAD synthase
- Riboflavin synthase
- 6,7-dimethyl-8-ribityllumazine synthase
- Uncharacterized mitochondrial carrier C27B12.09c
- Low molecular weight phosphotyrosine protein phosphatase
- Acid phosphatase
- Probable acid phosphatase SPBC4.06
- Thiamine-repressible acid phosphatase SPBC21H7.03c
- Thiamine-repressible acid phosphatase pho4
- Uncharacterized protein C4C5.01
Sequence:
MTVNLEEKRPEIVGPEKVQSPYPIRFEGKVVHGFGRGSKELGIPTANISEDAIQELLRYRDSGVYFGYAMVQKRVFPMVMSVGWNPYYKNKLRSAEVHLIERQGEDFYEEIMRVIVLGYIRPELNYAGLDKLIEDIHTDIRVALNSMDRPSYSSYKKDPFFKV
Protein: NEDD4-binding protein 2-like 2 (Phosphonoformate immuno-associated protein 5 homolog) (Q8JZS6)
Organism: Mus musculus (Mouse)
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 7
Sequence:
MPYSEVEAKFLGPGKEQTREPCYKKLKSAADDGVSPLRGGPDIHRIQEKPRNNRVAVATINFRRRVCPQEDKTSTDVLKPLHKEMPGDKLGGSESIGSPALQDGKPSPLAKDDEIYSTSKAFIGPIYKPPEKKKCRERKSETDTFSSIDSKRRQEEKQKSNSKKLEMDTELSQFYKEIEELENENEASQGSCTEPEPSEEPIISYDWACNTLKSEEENKDLSDVLQSHCGYQEYLEDEPDYPCDEQLMPAFCETSFPSFRPEWQSMHPFVIPHDPLSSFNYFNFQRFGTPLHPSPDVFHGRDDSQMQNGCYVDSYQDGWSCLTFDQNDEYANYDVTSNNVHPFRNGCSVQDESVNNGFCEIRECWQDPSMDKHNETDRFVNQWFQEEKLNKLQKLLILLRGLPGSGKTTLSRILLGQSRDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQNRAKQAIDQGRSPVIIDNTNTQAWEMKPYVEMAIGKGYRVEFHEPETWWKFDPEELEKRNKHGVSRKKIAQMLDRYEFQMSISIVMNSVEPTQKSIQRPLPLEGEQRWGGSLGSHSQVSIADDY
Protein: Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 12 (AthCYSTM12) (Q6NN03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in resistance to abiotic stress.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29272523}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:29272523}.
Interaction partners:
Sequence:
MQDMRDQNPPQGYPAAEQVSEQPGQDKKKKKPRFFETKQKGDRGFIEGCLFALCCCWICEMCF
Protein: Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) (P32746)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uridine 5'-monophosphate synthase
- Dihydroorotase, mitochondrial
- Dihydropyrimidinase
- Carbamoyl phosphate synthase arginine-specific large chain, chloroplastic
- Aspartate carbamoyltransferase, chloroplastic
- Carbamoyl phosphate synthase small chain, chloroplastic
- Allantoinase
- Nitrate reductase 1
- Nitrate reductase 2
- NADH-cytochrome b5 reductase-like protein
Sequence:
MAGRAATSSAKWAREFLFRRVSSNPLGATRNCSSVPGASSAPKVPHFSKRGRILTGATIGLAIAGGAYVSTADEATFCGWLFNATKVVNPFFALLDAEFAHKLAVSAAARGWVPREKRPDPAILGLEVWGRKFSNPIGLAAGFDKNAEATEGLLGMGFGFVEVGSVTPVPQEGNPKPRIFRLSQEGAIINRCGFNSEGIVVVAKRLGAQHGKRMLAETSATSSSPSDDVKPGGKSGPGILGVNLGKNKTSEDAAADYVQGVHNLSQYADYLVINVSSPNTAGLRMLQGRKQLKDLVKKVQAARDEMQWGDEGPPPLLVKIAPDLSRGELEDIAAVALALHLDGLIISNTTVSRPDAVSNNPVATETGGLSGKPLFALSTNMLRDMYTLTRGKIPLIGCGGVSSGEDAYKKIRAGATLVQLYTGFAYGGPALIPQIKEELVKCLERDGFKSIHEAIGADHR
Protein: Acetyl CoA transferase-like protein (Q8R4V3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MNTRSDPVVIVSAARTAIGSFNGALSTVPVHEMGTTVIKEVLQRAKVAPEEVSEVIFGHVLTAGCGQNPTRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAAQSIAMGDSTIVVAGGMENMSKAPHLTHLRTGVRVGEVPLADSILCDGLTDAFHNYHMGITAENVAKKWQVSREAQDKVAVLSQNRAEHAQKAGHFDKEIVPVLVSSRKGLTEVKIDELPRHGSNLEAMGKLKPYFLTDGTGTVTTANATGMNDGAAAVVLMKKTEAERRMLKPLARIVSWSQAGVEPSVMGVGPIPAIKQAVAKAGWSLEDVDLFEINEAYAALSVAIAKELGLNPEKVNIDGGVIALGHPLGASGCRILVTLLHTLERVGGTRGVAALCIGGGMGVAMCVQRG
Protein: Photosystem II reaction center protein M (PSII-M) (P0C413)
Organism: Oryza sativa subsp. japonica (Rice)
Function: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00438}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00438}.
Interaction partners:
- Photosystem II CP47 reaction center protein
- Photosystem II protein D1
- Photosystem II reaction center protein L
- Photosystem II D2 protein
- Photosystem II reaction center protein H
- Cytochrome b559 subunit alpha
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein K
- Photosystem II reaction center protein J
- Cytochrome b559 subunit beta
Sequence:
MEVNILAFIATALFILVPTAFLLIIYVKTVSQND
Protein: TIA1 cytotoxic granule-associated RNA binding protein (F7FKD5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVRTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVSQSSPGNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFIRFSSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPPAYGQWGQWYGNAQQIGQYVPNGWQVPAYGMYGQPWSQQGFNQTQSSAPWMGPNYSVPPPQGQNGGMLPNQPAGYRVAGYETQ
Protein: C2H2 finger domain protein, putative (AFU_orthologue AFUA_6G02690) (Q5ASI9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Uncharacterized protein
Sequence:
MDLANLISQPGPEPALTAKSRYSPPAFEPGSFYAASTSFTRTQAPLSPPVEDRSSRCSLPSISALLDSADGASTQAPKRQRLSSPMHREPLDKNPSAGAAPIRLPPTPPLRPGSGFHSAGHSPSSSISSISMIKSEYPAPPSAPVSLPGLPSPTDRSSISSQGSAPQHQHGPYASPAPSVAPSYSSPVEPSPSSAMYYQHQRPASSGTYQAPPPPPQHQPMISPVTPAWQHHHYFPPSSNTPYQQNHDRYICRTCHKAFSRPSSLRIHSHSHTGEKPFRCTHAGCGKAFSVRSNMKRHERGCHTGRAVAMV
Protein: Anoctamin (A0A0G2K052)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU280814}.
Interaction partners:
Sequence:
MQDTQDSDISLEGLTREGAPADRECQRGPETIVHEAQDAGTPNSDATGAVDGEREATMRVPEKYSTLPAEDRSVHIVNICAIEDLGYLPSEGTLLNSLSVDPDAECKYGLYFRDGKRKVDYILVYHHKRASGSRTLARRGLQNDMVLGTRSVRQDQPLPGKGSPVDVGSPEAPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWHVLCREAEFLKLKMPTKKVYHISETRGLLKTINSVLQKITDPIQPKVAEHRPQTTKRLSYPFSREKQHLFDLTDRDSFFDSKTRSTIVYEILKRTTCTKAKYSMGQGEGRRKDSALLSKRRKCGKYGITSLLANGVYSAAYPLHDGDYEGDNVEFNDRKLLYEEWASYGVFYKYQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGCATVDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLRKESRNKETDKVKLTWRDRFPAYFTNLVSIIFMIAVTFAIVLGVIIYRISTAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLTFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKFIRYLKLRRQSPSDREEYIKRKQRYEVDFNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISFTSDFIPRLVYLYMYSQNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQGKQQLLDTWMEKEKPRDVPCNNHSPTAHPEAGDSSPVPSYEYHGGAL
Protein: Gonadotropin-inhibitory hormone (RFamide-related peptide GnIH) (Q75XU6)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Neuropeptide FF receptor 1
- Follitropin subunit beta
- Protein XRP2
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Small ribosomal subunit protein mS26
- Progonadoliberin-1
- Cytochrome c oxidase subunit 1
- G_PROTEIN_RECEP_F1_2 domain-containing protein
- Cytochrome c oxidase subunit 3
- Prolactin releasing hormone
Sequence:
MEVISTQKFILLTLATVAFLTPHGMCLDELMKSSLESREEDDDKYYEIKDSILEEKQRSLNFEEMKDWGSKNFLKVNTPTVNKVPNSVANLPLRFGRSNPEERSIRPSAYLPLRFGRAFGESLSRRAPNLSYRLGRSPLARSSIQSLLNLPQRFGKSVPINLSQGVQESEPGM
Protein: Claudin-4 (B9EP74)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MLGTALGIIGWIGAIVVCALPQWKVTAFIGENIITAQTTWQGIWMNCVVQSTGQMQCKVYDSMLALPQDLQAARALIIISIMMGLVGILLSVAGGKCTNCVEDERTKSRIGVGSGVVFIIAGVLCLIPVCWSANTIIRDFYNPMLNSSQKMELGAALYIGWGAAALMIIGGGFLCANCPPKEDNYPTKYSAARSTAPRDYV
Protein: SET domain-containing protein (Q582H7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- SET domain-containing protein
Sequence:
MVRLRSAWVAQQSSRELNTYLRQRAWHFASCGNHAIAADYVIRLLNRHPRDATMLLLGEVTARRTRQKQLEAKCRQSHERLCTCMNVNNALSLVEDERKRETLKEWLQEPPPADDVELEEHIIVSEQEPLPETQTAVEVMAQRVSAKPLVGLQFPKQSIYGRGIYALTRVPSGTAVLADQPFVVQRMNSTTCAHCLSSITSASSTSSAAGVVCPHCGQESYCSISCRDAAWREYHSCCCHATNKMYASWESSMQELFSTDVPEESRAALCCLAVAKICAMATVQQQHPLSLPRLRSLRGRATYDAATALSEVGALAVTLAQSLHQQHLYMEEILSLFALVQTNEFLLSGGMALYHGYSFLNHSCEPNCGFVGTNAMNRRLVVLRDIREGEQLLINYNADLTTCVSYEDRRALCKQRYFECFCPKCIRRE
Protein: Type VI secretion system component TssA1 (Q9I750)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Core component of the H1 type VI (H1-T6SS) secretion system that plays a role in the release of toxins targeting both eukaryotic and prokaryotic species. Forms a dodecameric ring-shaped structure located at one end of the T6SS sheath. May properly attach the pre-assembled sheath onto the baseplate and/or stabilize the sheaths tubular structure.
Interaction partners:
- Type VI secretion system sheath protein TssB1
- Type VI secretion system spike protein VgrG1a
- Protein hcp1
- Type VI secretion system sheath protein TssC1
- Type VI secretion system spike protein VgrG1c
- Type VI secretion system component TssE1
- OmpA-like domain-containing protein
- Type VI secretion system baseplate subunit TssG
- Type VI secretion system accessory component TagJ
- Type VI secretion system lipoprotein TssJ
Sequence:
MLDVPVLLAAVSPDSPCGDDLEYDAAFLELERIAQGQPERQMGDAVLPAEPPEWPRVRALASELFGRSKDLRVANLLLQSNVALDGLDGLADGLLLVRELLGQYWDGVYPLLDADDDNDPTFRINALTGLVAEPLLQLVWAIPLVRSRAFGPVNLRAALNAAGLQRFASETLSPEQIAGAFADADADALAATRRALDGAQEHALAIESGVAERVGSAQGLDLGPLRQLLRQALQVFDLYGPQGAGESLAPGAEAVADEQVGAAPVAAVAAPAPRASGEIANREDVLRQLDRLLEYYVRHEPSSPVPVLLKRAKTLVTADFAEIVRNLIPDGISQFETLRGPESE
Protein: UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein) (Q04323)
Organism: Homo sapiens (Human)
Function: Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1. Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B. Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23545497}.
Interaction partners:
- UBX domain-containing protein 7
- Transitional endoplasmic reticulum ATPase
- FAS-associated factor 1
- FAS-associated factor 2
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
- Large proline-rich protein BAG6
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
- Melanoma-associated antigen D1
- BTB/POZ domain-containing protein 9
- NSFL1 cofactor p47
Sequence:
MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVAKKCPS
Protein: Phosphoglycerate kinase (EC 2.7.2.3) (Q04LZ5)
Organism: Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00145}.
Interaction partners:
Sequence:
MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEESDKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEAAINALEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
Protein: Eukaryotic initiation factor 4A-2 (eIF-4A-2) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) (DEAD-box ATP-dependent RNA helicase 19) (P41377)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor isoform 4G-1
- Eukaryotic translation initiation factor isoform 4G-2
- Eukaryotic initiation factor 4A-1
- Eukaryotic initiation factor 4A-3
- Altered inheritance of mitochondria protein
- Eukaryotic initiation factor 4A-III homolog
- ATP binding / ATPase
- ARM repeat superfamily protein
- RING-type E3 ubiquitin transferase
Sequence:
MAGSAPEGTQFDTRQFDQRLNEVLDGQDEFFTSYDEVHESFDAMGLQENLLRGIYAYGFEKPSAIQQRGIVPFCKGLDVIQQAQSGTGKTATFCSGVLQQLDYALLQCQALVLAPTRELAQQIEKVMRALGDYQGVKVHACVGGTSVREDQRILQAGVHVVVGTPGRVFDMLRRQSLRPDCIKMFVLDEADEMLSRGFKDQIYDIFQLLPPKIQVGVFSATMPPEALEITRKFMSKPVRILVKRDELTLEGIKQFYVNVEKEDWKLETLCDLYETLAITQSVIFVNTRRKVDWLTDKMRSRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINFDLPTQPENYLHRIGRSGRFGRKGVAINFVTLDDQRMLFDIQKFYNVVVEELPSNVADLL
Protein: glutamate synthase (NADPH) (EC 1.4.1.13) (Q72B16)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Glutamate synthase, amidotransferase subunit, putative
- Pyridine nucleotide-disulfide oxidoreductase
- Glutamate synthase alpha subunit C-terminal domain-containing protein
- Glutamate synthase, small subunit
- Pyridine nucleotide-disulfide oxidoreductase
- Pyridine nucleotide-disulfide oxidoreductase
- Cysteine-rich domain/iron-sulfur cluster-binding domain protein
- Glu/Leu/Phe/Val dehydrogenase family protein
Sequence:
MRSKPISQHFNDFVVERERARCIDCEVCVRQCSYGVHFWDEARKRVEHDSSKCVGCHRCAAMCPTDCLTIRRKPSDFRENALWTPAFIKNIYKQSDTGGVLLSGMGCPSPKPVYWDNMLLDASQVTNPSIDPLREPMELRTFLGGRPDRLVFEETPQGPKLQTEIGPQLQLEYPIMFAAMSFGAINYNLHEAMAKAATELGTFYNTGEGGLHPDLYPYGANTIVQVASGRFGVHKDYLNAGSAVEIKVGQGAKPGIGGHLPGEKIDEEVSRTRMVPKGSDAISPAPHHDIYSIEDLLQLICAIKEATQYRVPVSVKIAAVHNAPAIASGIVRAGADIVVIDGFRGGTGAAPTMIRDNVGIPIELALAAVDDRLRDEGIRNRASIVAAGGVRCSADVVKAIALGADAVYIGTAALIAVGCTLCGRCYTGKCPWGIATNESRLKKRQNPDEAARRLTNLVRAWGHEIQEMLGGMGLNSIESLRGNRDKLRGIGLGDTELDILGIKHAGR
Protein: LIM domain-containing protein 1 (Q06BR1)
Organism: Xenopus laevis (African clawed frog)
Function: Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MDTYDELSLEASKFIQDLTLYEASKDGLFRVDKGLSNNPEFEETKRIFAAKMAKIHLQNQQKSIPDTGISEGNGLTHQYNYSLPKSVEEGPVIYNGLSNSSVGPSDYKTYRESYKGKPDIDSADRSEESVFKHDSEIMLPSPLGKVGNTIPTQQFTSKKAISPSIESLERERTIKNNITGFENYRLCNSSSMKNCKPHQNSRHGEVEDTMAENFTENKTPFKQCSALISSSVTFGDDTHTNIPQKKLFNLPSTSSINTQNNSDDVYLSKTNAAKEFHGEQRGLCSTNSLGFGNPNDVISASYCVGYNDNFPGEIKQKQSPHYTFHSGHSSVDEQPQAIPFCCKDSSGQGPASTIDSDHTDILQDSSALMKIKLPCQTLSQSSKQGSSKAEKKLEAITRHVEQEMDAHNKADYFGTCVKCSKGVYGASQACQAMGNLYHNGCFICSACSRKLRGKAFYFVNGKVYCEEDFLYSGFHQSADRCFVCGHWIMDMILQALGKSFHPGCFRCVVCNECLDGVPFTVDMENKIYCVKDYHKILAPKCAVCSLPILPSEGTDETIRVVSMDKDYHIDCYRCECCALELNNEDDHRCYPLDGHLFCHNCHLKYLENHNLS
Protein: Small ribosomal subunit protein bS1m (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt) (Q9Y2Q9)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25838379}.
Interaction partners:
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein mS23
- Small ribosomal subunit protein mS27
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein mS37
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein bS21m
Sequence:
MAALCRTRAVAAESHFLRVFLFFRPFRGVGTESGSESGSSNAKEPKTRAGGFASALERHSELLQKVEPLQKGSPKNVESFASMLRHSPLTQMGPAKDKLVIGRIFHIVENDLYIDFGGKFHCVCRRPEVDGEKYQKGTRVRLRLLDLELTSRFLGATTDTTVLEANAVLLGIQESKDSRSKEEHHEK
Protein: ATP synthase subunit d, mitochondrial (A1ZAH1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}.
Interaction partners:
- ATP synthase subunit gamma, mitochondrial
- ATP synthase subunit alpha, mitochondrial
- ATP synthase F
- ATP synthase subunit g
- ATP synthase F
- ATP synthase subunit b
- ATP synthase subunit g
- Putative ATP synthase subunit f
- ATP synthase, coupling factor 6-like
- ATP synthase subunit b, mitochondrial
Sequence:
MWEKLVNCIKSNGGNGGVKNVSCQVVELADLMKQVPPNQMHKFKMFAKKHEEYKDRVRKYPESMPTIDWEYYRQNVREEFVDWVKGYETKYDKLHSVFENRHAIVDHKRYFELVDEEKKVVTKCISEYKAESDKRIQELTEKLEFVKAMRPYSEMTMEEFCFARPHLAPDFINKPTFWPHTPEEQMPGPSDPEAAAALHHEEEPEPPKKPAPEKLPDKPSGEGKPPAAAAPKEPKEPVVDTSQLAEKATLIAKDLMAKAIVLFNSLKEKMSGLAKNVQKKADAAKAARSETASKSATPTAAPTKSLDSITERESGPNICNQTIIRSEEAEANPEVKARHTNLSIEADPCDAQEERAREIARTLERKRQLKEAEEWEKHKTKKDPCDAEKETDPCKLMEEETVCKPDPCKAKEEEAVCKPDPCQQKEKEDDICKPDPCKPKDEEGSCEDEEDPCKKKPKCDGDYQFGGDNEGGSTKSKQQDQVFINISECSKELAKQEEKKSGDSGKPKEKASLSEIPQGSDQKPVLGMQITESKDSKKDHKASIEGANEIGPVYTDPNQLAELLVQKKEKPVIIEEAQKPEDDKPITIYPKLEISANPKGDQVKQEAEGQKSPKDMAKQVFTMASGAATLLTEATNTLEDLKRKKEARLEALEQAYTSAQRQAQGALAEASKAVEAANNLAIRSAEQTGEVSSRDREALEMAEKHAILAKMLAGRAVALKDEIARVLKDLKKKK
Protein: BK channel (H7BRM7)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGEIYSPSQSKGFNQPYGYPMNCNLSRVFMEMTEEDRKCLEERKYWCFLLSSITTFCASMILVVIWRVVTHLCCQRREKEFVEPIPAPEAVQINMNGSKHAPSETDPFLKQQEEKHLGWMTEAKDWAGELISGQSLTGRFLVLLVFILSIGSLIIYFYDASFQNFQVETCIPWQDSPSQQIDLGFNIFFLVYFFIRFIAASDKVWFLLEMYSWIDFFTIPPSFVAIYLQRNWLGFRFLRALRLMTVPDILQYLNILKTSSSIRLTQLVTIFVAVCLTGAGLVHLLENSGDFFKGFINPHRITYADSVYFVLVTMSTVGYGDIYCTTLCGRLFMIFFILFGLAMFASYVPEIADLIGNRQKYGGEYKGEHGKKHIVVCGHITYDSVSHFLQDFLHEDRDDVDVEVVFLHRVVPDLELEGLFKRHFTKVEFFTGTVMDSLDLSRVKIGDADACLVLANKYSTNPDAEDAANIMRVISIKNYSSDIRVIVQLMQYHNKAYLLNIPSWDWKRGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSQTTPDWLNLYLCGAGMEMYTDTLSHSFVGMTFPEAVDLLFNRLGLLLLAIELKDEENKECNIAINPGPHIVIQPQTQGFFIAQSADEVKRAFFWCKQCHDDIKDVSLIKKCKCKNLALFRRNTKHSTAARDYSDFDALFYQNDARATDVLQQFQPQAPAGPMGHLGQQVQLRMINQQRPSSGGRRNSMSIPPDGRGVDFSKDFEQQFQDMKYDSTGMFHWCPSRNLEDCVLERHQAAMTVLNGHVVVCLFADQDSPLIGLRNFIMPLRSSNFHYHELKHVVIVGDLEYLRKEWKTLYNLPKISILNGSPLSRADLRAVNINLCDMCVIISARVPNTEDTTLADKEAILASLNIKAMQFDDTLGFFPMRHQTGDRSPLGSPISMQKKGAKFGTNVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRGGYSTPETLSNRDRCRIAQISLQDNPYDGVVHNTTYGAMFTIALRRYGQLCIGLYRLHDQDNPDSMKRYVITNPPAELRIKNTDYVYVLEQFDPGLEYEPGKRHF