wanglab/gogpt-training-data huggingface dataset:
Protein: GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) (Q8IWJ2)
Organism: Homo sapiens (Human)
Function: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.
Subcellular location: Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Interaction partners:
- Ras-related protein Rab-6A
- Syntaxin-16
- Ras-related protein Rab-9A
- Syntaxin-10
- Glutamate receptor-interacting protein 1
- CLK4-associating serine/arginine rich protein
- E3 SUMO-protein ligase RanBP2
- Golgin subfamily A member 4
- Ras-related protein Rab-9B
- Ras-related protein Rab-6B
Sequence:
MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSGWASYLHSWSGLR
Protein: Probable rho GDP-dissociation inhibitor (Rho GDI) (Q20496)
Organism: Caenorhabditis elegans
Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Ras-like GTP-binding protein rhoA
- Cell division control protein 42 homolog
- Ras-related protein ced-10
- Ras-related protein rac-2
- Rac-like GTPase
- Actin
- CHp/Wrch Rho-like protein homolog
- Twinfilin
- ADP-ribosylation factor-like protein 3
Sequence:
MSDHENTGENTSEYQYKQPPQKSIDELLNADKEDESLKVYKAKLLGQGTVIVDEKNPLRVIVRSVELLINGKTAQSFDLSDPAKLVNSDLSVSIKEGSNYRLSFAFHVQREITSGLHYKHKVKRSGITVENEKYMMGSYAPKLEIQEYKSPNEEAPSGMMHRGKYKVYSKITDDDNNVYLDWQWTLHITKE
Protein: Jitterbug, isoform L (Q9W204)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDVKDIKGAKVTHAGLLKHNSDGTTETQKITHAGLVARSPEGTAAKGMNIRGNEDLWVEIQANTFRNWVNEHLRETGMQVHDWATDFCDGTCLCALVENLQTRPLKPSWNRRPANQHHYLENATTALKSIEADHIKLVNIGNVDIVNGNIKLILGLIWSLIVRYQIGRSKFPPRKLMLAWLQAALPDCRITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLDPSQSVRNCTQAMDLAQREFGVPKVLEPEYLASPWLDELSGMTYLSYFMKPGGPGYNATMRWVNTQVKDPVKNFTTDWNDGRVMCEIIKGLGGSAPAPEKLSTDPFHYENNIRKAVDAGARLGVQPILTAKDMANPEVEHLGIMAYAAHLQWVPPRPPLSDLVSVYLESTSGRVGEPTHFRIDVMSRDISLSSVRCHVVPPSGQPGQPVRLNAHGEGVFVPERYGMHEIVVEIGEDSLGGHFFRALPRLLQVAPPGMAPCALGSLVEVLVNATGAPKTEDILVTAVSPTGISHNCPLKKIDEGHSAIFKPDEAGIWEIAITYQGRHIQGGPFTCAVFDASGVSVHGLDGAMPLRAHTFEVDARGVGVSGELHVDIVHDKHSLVCSVEKIVENKYRVTFMPRQNGKYRVYIYFNGYDVKGSPFIMRVGTKGRSGKTRSSPLHDSKHRSESPSMHFVSTTNTRHNDYRNSSLSRHNTAERTNSYSPQYSPKLDTTDYHSSSSRYYKRESEENHATPPPAPPPASGSPTVKYLNSADLYTETLNGRRDSKTSNSSSTKNDYYYDKENELYSQRRAVTKPKLTPPREERELTSTTNTSSSSSFQQRHQQLATSTLTRSLSPIPSPTLNTRSSEVHTHSPLTIKTSNQYESSTRNITSSPRHASVSPVQRYSPNSAYITTATHRMGSPLTSPVSKNGYESSRTVEKSSTYKSTSNYVTDSNIRASPSLYGTAERLRRTGSPEPRIDHSSNVRVSSMKPASARRDSWDVINKTKHMLSHNSLESLANMTEKQLNTELQYNRPDLDHETHRNTQYNKFALHKQQQQQSDYRRDSPDDGERYKPSAITVKSHSNNTYTDKSGGYTKTVKESSEHVVTESNGHGPSPGYGYSSLSRFRPIDGNATGARAIRVQDIPNGSIGRPVEFEIDGSRAGSGNLEILVNGGRVTSSVRSLGGQRFIASFTPHEHGTHTVQITFNGETVPGSPWHAEIMSSPGLTALGESTRLVPANTPAVFEILPPPGQSLSKGECVATVLTPSKSKLNARVTHEAANGAARIEFVPTEVGTHVIDASINGTKIAGGPLIAKVYDSSLIQVTEVNGGVVGQACQFRVDASAAGEGQLEISINEGEVPNHVQVVGGGRCLVSFTPEQAKSHLIDIKFNGETVRGCPFVCAVADTSRVLLNLSNLELIPVNRPSSFHITVSGGGAAELAVSVRGPQGELPVRVTGDIHAGFTAEFTPTTVGGHSINVEYNGFAVQGTPFLAKSYDASKVVVGSVSRGTMGRPVQFTVDAGDAGEGNLEITISAKGQNIPTQVHPQGSARFSVSFVPTESCEHTINVSFNKMPVPGCPITVSISGGVAGPQVSLGGPGPVHQTNSFVINHNGGRLEDIEVNVEGRRNLLY
Protein: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) (dMyt1) (Q9NI63)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of Cdk1 specifically when Cdk1 is complexed to cyclins. Mediates phosphorylation of Cdk1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of Cdk1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:11882391}; Peripheral membrane protein {ECO:0000305|PubMed:11882391}.
Interaction partners:
- Serine/threonine-protein kinase polo
- G2/mitotic-specific cyclin-B
- Cyclin-dependent kinase 1
- Cell division cycle 14, isoform A
- Protein phosphatase PP2A 55 kDa regulatory subunit
- Ovarian-specific serine/threonine-protein kinase Lok
- FI11703p
- Protein mini spindles
- M-phase inducer phosphatase
- Protein arginine N-methyltransferase 5
Sequence:
MEKHHRLPLPELHDDKHRHKQCNGENSNRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDSSTLPSSPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQRIPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQGHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQYLQKKRKSLMNFSMLSRSFRRSRRAVWGRMCNWKTAAFRYLLYFLEVLHLCKPITASQPNINIVPSSPSSKGVPLVPQVEFQLVGSTPIANRDCYASDFLSGEDPLDLSNQGSPNVINSTPLNTNQGKSRLDLLKNNVDSMGRYVHVHDFESPCSALSSAKVLDTSSFRRKKLFVLEYDDE
Protein: Cilia- and flagella-associated protein 300 (Q9BRQ4)
Organism: Homo sapiens (Human)
Function: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A0CY51}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A0CY51}.
Interaction partners:
- Cilia- and flagella-associated protein 298
- Dynein axonemal assembly factor 6
Sequence:
MATGELGDLGGYYFRFLPQKTFQSLSSKEITSRLRQWSMLGRIKAQAFGFDQTFQSYRKDDFVMAFFKDPNVIPNLKLLSDSSGQWIILGTEVKKIEAINVPCTQLSMSFFHRLYDEDIVRDSGHIVKCLDSFCDPFLISDELRRVLLVEDSEKYEIFSQPDREEFLFCLFKHLCLGGALCQYEDVISPYLETTKLIYKDLVSVRKNPQTKKIQITSSVFKVSAYDSAGMCYPSAKNHEQTFSYFIVDPIRRHLHVLYHCYGVGDMS
Protein: ethanolamine kinase (EC 2.7.1.82) (E9ADC3)
Organism: Leishmania major
Interaction partners:
- Uncharacterized protein
- Raptor N-terminal CASPase-like domain-containing protein
- Raptor N-terminal CASPase-like domain-containing protein
- Putative choline/ethanolamine kinase
- Putative ras-like small GTPases
- Putative ras-like small GTPases
- non-specific serine/threonine protein kinase
- Zinc finger protein kinase-like
Sequence:
MVQFTDTWITDDPLLRQIQIVEVVLTHCASVLWRYNEAKLKGAPEWAAKLRALLKAKAKRLGGDSSCRSPESCASQRSMTPQKKHKGLTAASADAIVYRENSKEDHPPQTTPTPQLPSSQQSFQVPPSHKRATAGAILPDAIPTTQGGSVFVDVAHSATHTNVNTFSESNTCSSTSLPHYPEAGAGNNRVCHFRAGPSPFVTPGVLFSSCRSTEEHLEELGAPPTAETTRQSEVAAVRASSSPPIERSNTPELPSAPLQMKRLSGGITNELFHVYDEDDPSASVVVRVFGKETDRVISRESELFYQSLFIPTYVHGSNFLVYDYLDGYYTLPYQDMAAEAMPIARAIAAFQVRATRAALRDHGHPLLRDSQNKDYWKIVDNQMLAIEGSTTSSHDTCKDESRFERESNYLIGSLTKWVDLVLSQEIIDRVREDQRESFLMMGRSLQSACAWMLSMLERQKAYLPEGVCHNDLLSANVMIHKVRKDVRVIDFDYTKRSFLLYDVANHFNEYPGLDCDYDTYFPSDAHMSTFIAEYRRGMRDALEAAWAENSSPTSSTDCASREHEIFPNARELFWSDREEAEAQVVAHWTRLAKLLTLASHLSWSVWSLLQEAVSALDVDFLNYAQTRYNRYLAVRAECSENL
Protein: Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) (P11275)
Organism: Rattus norvegicus (Rat)
Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity).
Subcellular location: Synapse {ECO:0000269|PubMed:15659234}. Postsynaptic density {ECO:0000269|PubMed:15659234}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9UQM7}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9UQM7}. Note=Postsynaptic lipid rafts. {ECO:0000269|PubMed:15659234}.
Interaction partners:
- Calcium/calmodulin-dependent protein kinase type II subunit delta
- Calmodulin-1
- Glutamate receptor 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta
- Glutamate receptor ionotropic, NMDA 2B
- Calmodulin-like protein 3
- Calmodulin-like protein 4
- Microtubule-associated protein tau
- Leucine-rich repeat-containing protein 7
- Glutamate receptor 2
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
Protein: Cartilage intermediate layer protein 2 (CILP-2) [Cleaved into: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2] (Q8IUL8)
Organism: Homo sapiens (Human)
Function: May play a role in cartilage scaffolding.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:21880736}.
Interaction partners:
- Pre-B-cell leukemia transcription factor 4
Sequence:
MASLLPLLCLCVVAAHLAGARDATPTEEPMATALGLERRSVYTGQPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTPSGQPLLGARVSLRDQPGTVATSDAHGTFRVPGVCADSRANIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCKAWNEAGAVRSGTARLTVLAPGQPACDPRPREYLIKLPEDCGQPGSGPAYLDVGLCPDTRCPSLAGSSPRCGDASSRCCSVRRLERREIHCPGYVLPVKVVAECGCQKCLPPRGLVRGRVVAADSGEPLRFARILLGQEPIGFTAYQGDFTIEVPPSTQRLVVTFVDPSGEFMDAVRVLPFDPRGAGVYHEVKAMRKKAPVILHTSQSNTIPLGELEDEAPLGELVLPSGAFRRADGKPYSGPVEARVTFVDPRDLTSAASAPSDLRFVDSDGELAPLRTYGMFSVDLRAPGSAEQLQVGPVAVRVAASQIHMPGHVEALKLWSLNPETGLWEEESGFRREGSSGPRVRREERVFLVGNVEIRERRLFNLDVPERRRCFVKVRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGRFDSAVTGPNGACLPAFCDADRPDAYTALVTATLGGEELEPAPSLPRPLPATVGVTQPYLDRLGYRRTDHDDPAFKRNGFRINLAKPRPGDPAEANGPVYPWRSLRECQGAPVTASHFRFARVEADKYEYNVVPFREGTPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNAGGSHPRTRGQLYGLRDARSVRDPERPGTSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRRVAVNGLLRDYLTRHPPPVPAEDPAAFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRCFDGSSDGFSREMKADAGTAVTFQCREPPAGRPSLFQRLLESPATALGDIRREMSEAAQAQARASGPLRTRRGRVRQ
Protein: AT3g25910/MPE11_6 (MAP kinase kinase kinase, putative (DUF1644)) (Q9LUA0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- C2H2 and C2HC zinc fingers superfamily protein
- C2H2-type zinc finger protein
- Glutathione S-transferase U5
Sequence:
MPKERKERSVSLDKYKRSPLCCEASLALKPSEKQVKEWEEARCPVCMEHPHNGILLICSSYENGCRPYMCDTSHRHSNCFDQFRKASKEKPSLSLLREEEESNEPTEMEDVDSDSTAVNLLGEAASEITVVDLSDGERGEEEVEEEEEEVVVEEEEEGIVTTEEDQEKNKPQKLTCPLCRGHIKEWVVVKAARCFMNSKHRSCSCETCDFSGSYSDLRKHARLLHPGVRPSEADPERQRSWRRLERQSDLGDLLSTLQSSFGGDEISNDDGFLFADTRLLTVYFLIRVFRPESSGSRSSSWSGTSRARTHTSGRRRSSRPASLWGESYEGNTGTSPRDEENNQSSDEQVSGTRRRRSRRRTVIDDDDEEEEP
Protein: H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10) (Q9CQS2)
Organism: Mus musculus (Mouse)
Function: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Note=Also localized to Cajal bodies (coiled bodies). {ECO:0000250}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit DKC1
- H/ACA ribonucleoprotein complex subunit 2
- H/ACA ribonucleoprotein complex subunit 1
- Telomerase Cajal body protein 1
- Telomerase reverse transcriptase
- NHP2-like protein 1
- Protein SHQ1 homolog
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- Nucleolar protein 56
- Nucleolar protein 58
Sequence:
MFLQYYLNEQGDRVYTLKKFDPMGQQTCSAHPARFSPDDKYSRHRITIKKRFKVLMTQQPRPVL
Protein: Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase) (P29288)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.
Subcellular location: Lysosome.
Interaction partners:
- Lysosomal acid phosphatase
- Riboflavin kinase.
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Biliverdin reductase B
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- FAD synthase
- Nuclear factor of activated T-cells 1
- Cathepsin K
- Tumor necrosis factor ligand superfamily member 11
Sequence:
MDTWMVLLGLQILLLPLLAHCTAPASTLRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQIMGADFIMSLGDNFYFTGVHDANDKRFQETFEDVFSDRALRNIPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPYYRLRFKVPRSNITVAIFMLDTVMLCGNSDDFVSQQPEMPRDLGVARTQLSWLKKQLAAAKEDYVLVAGHYPIWSIAEHGPTRCLVKNLRPLLAAYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSVRHQRKVPNGYLRFHYGSEDSLGGFTYVEIGSKEMSITYVEASGKSLFKTSLPRRPRP
Protein: Neuroguidin (D3ZBL3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Nucleolar protein 10
- KRR1 small subunit processome component
- WD repeat-containing protein 46
- U3 small nucleolar RNA-associated protein 18 homolog
- Probable U3 small nucleolar RNA-associated protein 11
- Something about silencing protein 10
- UTP6 small subunit processome component
- UTP14A small subunit processome component
- Periodic tryptophan protein 2 homolog
- U3 small nucleolar RNA-associated protein 4 homolog
Sequence:
MAVTAQVQALTAKVRAGAYSTEKGLSLLEVKDQLLLMYLMDLSHLILDKASGGSLQGHPAVLRLVEIRTVLEKLRPLDQKLKYQIDKLVKTAVTGSLSENDPLRFKPHPSNMMSKLSSEDEEENEAEEDQSEASGKKSVKGASKKYVPPRLVPVHYDETEAEREQKRLEKAKRRALSSSVIRELKEQYSDAPEEIRDVRHPHVTRQSQEDQHRINYEESMMVRLSVSKREKGLRRRASAMSSQLHSLTHFSDISALTGGTAHLDEDQNPVKKRKKMPKKGRKVFGGAGDELMHALLVITVCRRLPWKCGKSF
Protein: Chemokine-like factor (C32) (Q9UBR5)
Organism: Homo sapiens (Human)
Function: May play an important role in inflammation and regeneration of skeletal muscle. Essential for embryonic development (By similarity).
Subcellular location: [Isoform 1]: Secreted {ECO:0000269|PubMed:11415443, ECO:0000269|PubMed:16137713}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- CKLF-like MARVEL transmembrane domain-containing protein 2
- CKLF-like MARVEL transmembrane domain-containing protein 3
- CKLF-like MARVEL transmembrane domain-containing protein 7
- CKLF-like MARVEL transmembrane domain-containing protein 4
- CKLF-like MARVEL transmembrane domain-containing protein 6
- CKLF-like MARVEL transmembrane domain-containing protein 5
- CKLF-like MARVEL transmembrane domain-containing protein 8
- Plasmolipin
Sequence:
MDNVQPKIKHRPFCFSVKGHVKMLRLALTVTSMTFFIIAQAPEPYIVITGFEVTVILFFILLYVLRLDRLMKWLFWPLLDIINSLVTTVFMLIVSVLALIPETTTLTVGGGVFALVTAVCCLADGALIYRKLLFNPSGPYQKKPVHEKKEVL
Protein: Origin recognition complex subunit 5 (Q9WUV0)
Organism: Mus musculus (Mouse)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O43913}. Chromosome {ECO:0000250|UniProtKB:O43913}.
Interaction partners:
- Origin recognition complex subunit 2
- Origin recognition complex subunit 4
- Origin recognition complex subunit 3
- Cell division control protein 6 homolog
- Origin recognition complex subunit 1
- Origin recognition complex subunit 6
- DNA replication factor Cdt1
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM2
- DNA replication licensing factor MCM3
Sequence:
MSHLESMVLCREAQVSTLQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHAFVNCVECFTSRLLLEQILNKLSHLNSSDAGCSTEMTCETFNDFVQLFKQVTSAEHLKDQTVYIVLDKAEYLRDMEANLLPGLLRLQELTDRNVTVIFLSEIIWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEAGERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDNTDPGQLKGLSAYTHMELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTIVGHEDQLNGPKYKCTVSLDFIRAIARMVNFDIIKYLYDFL
Protein: Large ribosomal subunit protein bL35c (50S ribosomal protein L35, chloroplastic) (Q8VZ55)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Large ribosomal subunit protein cL37
- Large ribosomal subunit protein bL9c
- Large ribosomal subunit protein bL28c
- Small ribosomal subunit protein bS6c
- Large ribosomal subunit protein bL27c
- Large ribosomal subunit protein uL29c
- Small ribosomal subunit protein bS20c
- Large ribosomal subunit protein uL18c
- Large ribosomal subunit protein uL11c
- Large ribosomal subunit protein bL17c
Sequence:
MASLSMASVNVSFCHPLRSSSPKVSLRSSVHFATSLSSSHSISGLRAVLPLKISTVASPNSQKLHSFTVFAHKGYKMKTHKASAKRFRVTGRGKIVRRRSGKQHLLAKKNNKRKLRLSKMTEVNRSDYDNVIGALPYLKVNRKAT
Protein: Prolyl endopeptidase (EC 3.4.21.-) (Q9SX53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAESRSPPVAKKVEHVMEMFGDVRVDNYYWLRDDSRTNPDMLSYLREENHYTDFVMSGTKQFENQLFAEIRGRIKEDDISAPLRKGPYYYYEKNLQGKEYIQHCRRLITDNKAEPSVYDTMPTGPDAPPEHVILDENTKAQEHDYYRIGAFKASPDHKLVAYAEDTKGDEIYTVNVIDSEALKPVGQQLKGLTSYLEWAGNDALLYITMDEILRPDKVWLHKLGTEQSSDVCLYHEKDDMFSLELHASESHKYLFVASESKTTRFVFSLDVSKTQDGLRVLTPRVDGIDSSVSHRGNHFFIQRRSTEFYNSELIACPVDDTSKTTVLLPHRESVKIQEIQLFRDHLAVFERENGLQKITVHRLPAEGQPLEGLQGGRNVSFVDPVYSVDSTESEFSSRVLRFKYCSMKTPPSVYDYDMDSGTSVVKKIDTVLGGFDASNYVTERKWVAASDGTQIPMSIVYNKKLAKLDGSDPLLLYGYGSYEISVDPYFKASRLSLLDRGFTFVIAHVRGGGEMGRQWYENGKLLKKKNTFTDFIACAERLIELKYCSKEKLCMEGRSAGGLLMGAVVNMRPDLFKVVIAGVPFVDVLTTMLDPTIPLTTSEWEEWGDPRKEEFYFYMKSYSPVDNVTAQNYPNMLVTAGLNDPRVMYSEPGKWVAKLREMKTDNNVLLFKCELGAGHFSKSGRFEKLQEDAFTFAFMMKVLDMIPASG
Protein: Fig1p (Q59WR6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Fus1p
- Alpha-factor pheromone receptor
- Kar4p
Sequence:
MNLPLKFTIVFTIIIQFITAALLSFLLLGCIDTSSNYSNVYLLSYKFNQSSPLYDYLSTSSNSSITTTTTTNNNSTAIDELSVKVGYMGVCLSSSSKDISCTTYTGLDSFPKFSISMLSGDLDLVQLAQSFSNICHPRILLATIILTLIGLIILCYCVIPIVPGKSIMKKLNAGLSFILLLLWGLGSMLQHQAVVTSVEMMQQSSFQLLIGTRGGRAEAMTWTAFSFILMMFLSACLSWWMEIRMSKLNGKSSQHQQQPSVDTKI
Protein: Peroxide stress-activated histidine kinase mak1 (EC 2.7.13.3) (His-Asp phosphorelay kinase phk3) (Mcs4-associated kinase 1) (Q9P7Q7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Also has a role in G2/M regulation.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Multistep phosphorelay regulator 1
- MAP kinase kinase kinase wis4
- Uncharacterized oxidoreductase C22A12.17c
- MAP kinase kinase kinase win1
Sequence:
MRPPDDQINNNVGSNSHLEKLKEAMDHQLQKSSKIVGSFTNSQNSSVGSVHSPILESPTSLNRQHRNSFSFNNVSSPSLEDERLINFPRVNPNRLMTSKRPNELFKTSSMSSDCYSPQKSRESLNSLCHSPAPSVSSCGNALNNDNTSASHSLTDEQPFETDSSANLFKQLQEKRNRTIGNVYEMACLLVFKTGLMNFWKNIIDFFAQQFFSTQISVVEPRDLSDIYNTPWQLRCYYDGGSHYDPYSNPISVNDNLASSSYVTVVASDGSKGIIYKDPASLKHEGDLLIDSKVVQTVLERATLLVYTRKQQHIVKNTKVHDNDYFSSIPNVDDIRSIKNSWKVFHDEKLNELKKQVEISASAAQLNGLYPQKKRAFVSHFSQNRKPYSQSDISKAQSSSFSEEPSNIYDEYEQNLLSPWSRSPVASPSIQTDPNRNPFFQNCLQESSFATESSTEKSASESVSETAVNDDCKGMNFSGNRRQEDHLNDFTSFPTETAVSIVHVPLMFPCSDQTSSRGRAPIAILSFKSNLVPYPENLIASIERLIPFIFSSYSNSQSVPLLPCPTQRHLLFNTSSTDNTKELSMSASSENSDCPHKEGECVGSFCNINAKGSSLNNIPKLPRFVPVPSEFFKKNQRSWVTLKKHRLLARLKSRISKKNSKVNENLRFSLNDGENYSNETITLKKDEIVLDKSKSYACCTSESHKYVQGHCGGQAPPFPLLKVIIDSIPVHVFTADPGSGKLTWVNRKTLLYCGLNMNEQIELQFSRIHPDDLPNFLNDWKSSLFSGSGFYHEIRLQRFDNVYRYFICRAVPLRDCTGSVLHFFGTMTDVHDQKLAERELQKQSAIAANENSYRSLAEASPQIVFAANGKNGIIYANAQWLSYSGLSLESSLGLGFLSAVYHADRKKCLLPESLEGTFNNQDESNGTKTFAAEIRFRSTDGHYRWHLVKSVCVNNSADTSTNLWLGTCTDIHDHKMLEEKLQESNIEAQRIVRSKMQYLSNMSHEIRTPLIGITGMVSFLLETQMSAEQLSYARIIQQSAKSLLTVINDILDLSKVRAGMMKLTSQRFSVRAMMEDANETLGTLAFSKGIELNYTVDIDVPDIVFGDNMRMRQVALNVIGNAIKFTNVGEVFTRCSVEKIDYSTNTVVLKWECIDTGQGFNRDDQLQMFKPFSQVESSTLPRHGGSGLGLVISKELVELHNGSMSCQSRRGVGTRFMWTATFTMDKTPLKFEPPDGCCPVCFCPYEKSKQSTEDYYCADDGNDKSATNFVKLAVNKADPGRESNRRKLESDKNVQSNKYVNPFASESEFCRCGASADPYTVLFWRLYRNKPSGIKLDKSALAVVVSHTKYSSEAIGNMLQSIIDISSFKDIVRYGNTYEAFEELLENPMQSKVTHIILNLPDIEAYVLFVKSLQLCSLYKDTKFILVTSTRQKESLSKIFSDSEDCNSESIHYVLKLVKPSKFFPLFYSDSEEKGKIGALNDMTRKAAMEQKADAETLRYNLAKSGFSVLLAEDNIINIKVISRYLERIGVKFKVTMDGLQCVEEWKREKPNFYSLILMDLQMPVMDGYQACNEIRKYELENDYPKVPIVALSANALPHVVLSCKDSGFDSYLAKPITLQHLSLIISGILNYTNQSKLHK