wanglab/gogpt-training-data huggingface dataset:
Protein: Retinol dehydrogenase 16 (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (Cis-retinol androgen dehydrogenase 1) (O54909)
Organism: Mus musculus (Mouse)
Function: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11279029, ECO:0000269|PubMed:15355969, ECO:0000269|PubMed:16223484}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:9407098}.
Interaction partners:
- Cytochrome P450 26A1
- Lecithin retinol acyltransferase
- Beta,beta-carotene 15,15'-dioxygenase
- All-trans-retinol 13,14-reductase
- Retinal dehydrogenase 2
- Retinaldehyde dehydrogenase 3
- Aldehyde dehydrogenase 1A1
- Diacylglycerol O-acyltransferase 1
- Aldehyde oxidase 1
Sequence:
MWLYLVALVGLWTLLRFFRVRQVVSHLQDKYVFITGCDSGFGTLLARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVTATQWVKEHVGNRGLWGLVNNAGISTPSGPNEWMKKQDFAHVLDVNLLGMIEVTLSMLPLVRKARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELSYFGVKVAIIEPGFFLTGVTSSARLCSNTQMLWDQTSSEIREIYGEKYLASYLKRLNKLDKRCNKDLSGVTDCMEHALTACHPRTRYSAGWDAKLFYLPLSYLPTFLVDALLYWTSLKPEKAL
Protein: Phosphopantothenoylcysteine decarboxylase (PPC-DC) (EC 4.1.1.36) (CoaC) (Q96CD2)
Organism: Homo sapiens (Human)
Function: Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A.
Interaction partners:
- Bifunctional coenzyme A synthase
- Phosphopantothenate--cysteine ligase
- Pantothenate kinase 1
- Pantothenate kinase 2, mitochondrial
- Pantothenate kinase 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Thymidylate synthase
- 4'-phosphopantetheine phosphatase
Sequence:
MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFYSPQDIPVTLYSDADEWEIWKSRSDPVLHIDLRRWADLLLVAPLDANTLGKVASGICDNLLTCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGAMAEVGTIVDKVKEVLFQHSGFQQS
Protein: N-acetylglucosamine-induced protein 1 (GlcNAc-Induced Gene) (Q59VM7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: N-acetylglucosamine-induced protein which plays a role in the N-acetylglucosamine metabolic pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20675577}.
Interaction partners:
- N-acetylglucosamine-6-phosphate deacetylase
Sequence:
MNPATIITNFNNSQLQTPPTSPVSFDKYYTYYNIQLEQSTLMPQPSKIKNGDPFTWSDIQFIIKSNQLEIFARSRQQTIKYHKFKQWLKDNKLSINDYLLDYELHWKESELREQQHELVSDKEYSIDYPEDLIFHNPNDISILYNKFPYYFEPNVKHICIWSKLKIPVDKNSEVGDISVMTKKLINRYLEKTFVAKGISWDQIVWFKNWLSLQSVRSISHIHVILKDVDDKFVDELISGGSGEVLTLDDYRNLE
Protein: Klrc3 protein (A1L3Q6)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MSHLLGTEQASEPRKATKKTQAQLHFSNAAGDRLLEFSLQHASQKHLKASRHGYCKNFASPPEKLIAGILGTIWFTLLIALVISTRIVSPYAELKKQIHPFLVRTQKGSHVLLSKDINHSLSSAQTYAHCPKEWILYSHNCYYIGMERKSWNDSLVSCISKNCSLLHIDSEEEQDFLQSLSLVSWTGILRKGRGQPWVWKKDSTFKPKIAEILHNECNCAMMSASGLTADSCTTLHPYLCKCKFPI
Protein: Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead-related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HFH-3) (HNF-3/fork-head homolog 3) (Q12951)
Organism: Homo sapiens (Human)
Function: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Pendrin
- ATP-sensitive inward rectifier potassium channel 10
- Gap junction beta-2 protein
- V-type proton ATPase subunit B, kidney isoform
Sequence:
MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTESSLPVDSPKTTEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGSPTSHPLVTPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHFYNSVNTSGVLYPREGTEV
Protein: Chloride intracellular channel protein 2 (Glutaredoxin-like oxidoreductase CLIC2) (EC 1.8.-.-) (Glutaredoxin-like peroxidase CLIC2) (EC 1.11.1.-) (XAP121) (O15247)
Organism: Homo sapiens (Human)
Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15916532}. Membrane {ECO:0000305|PubMed:15916532}; Single-pass membrane protein {ECO:0000305|PubMed:15916532}. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
Interaction partners:
- Chloride intracellular channel protein 5
- Chloride intracellular channel protein 4
- Mitogen-activated protein kinase 15
- Polyhomeotic-like protein 3
Sequence:
MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYANVAKQKS
Protein: AT25839p (Q5U0U9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
Sequence:
MKIKELQKTVNIAWSPAKQQQILLAAGTAAQQFDSNANSTLELYSPNFSDATYDLELRASVSSQYKFQKLIWSPVGPHPSGLIVGGCEAGQINIYSADKLLAGKEEPLLKRQDKHTGAVSGLDFNPFQNNLLASCASESEILIWDLNNPETSMSPGTKTQPLEDVKNVAWNRQVQHILASVFSTRCVIWDLRKSQQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAPAKTYQIHERGVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCPRNPALIASASLEGAVSIYSLHGGTHHLVQTANKIADSFPGMDQFAQEPIPQQATQVVYHDLAHAPKWMKRPCGVAFGFGGKLVSFNGTSKTVKVQQLTTESALVDRANALERSLVDANYSDYCRQRADETPDQHGRYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKFNKFIKETDGNSHSDVDTLTTRISTLTHTQDNKFDGNAIDSQNHNDFATPPRPQFKVPSGDHSDSLIAEAILTGNVDAAVELCLEAQRIPEALIIASTAGIETLNRTQTRYLLQQKNELSHVISALVSRDWLDFVNRCTVDSWKEALVAALKHSERKVVDICERLGDRLLSECASSAEFTRNAMLCYICAGSIDKLVTAWYQLKRLEQQNPGYKPNTTELQDLAEMVMLMCKSLEQQGISVDLAGRFAGFLTEYGGLLASQGALTAALQYITTLGGGAAASESDVLQSLRDRINNAVNLDYTQPQAAVAAAPHGYQPTRGRGSFSQPQPSAPMPYGQPPNQYAQPSWPAQVPPLQTSYPGAQQPQAPPQIFNPQPVKPEPLAQPPRPLSNASSSGGPPPAGGASSSGGSGLSGRSKYVLDPSVAAPTSSYGMPYNPVPAPVPSAVPFGGGGVPGPAPQPASVPTYNSNAFNTNPIAAAQPYNPSPLMPAQQNQFVPGVNPIETMPPPAVPPVIQNVQRNPTPPPGWNDPPALKSSRAPKPKPVVEPSAAIFHPLFPVDPNQNQNGYVDPSQYQHAAPPGGVPNTYYNPAAFNNNPQQQQQHQQSYLQPQQPAPGIQQPNWQGQQQTIGYTEQPAPIQQQRQPAPPKEKPPLPEEYIYLQTVLEELKNRCLGATNDPRTKRKFVDVVKRLENLYDCLRDGKLTPTTVQYLNQIVQYIQISDYANAMEIHTQIAFGTDFAQCAGFMQGLKVLLQSASELQLVLR
Protein: Kinesin-like protein (O62528)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAVPRTPMRVVPKTPRVHQTVEKQRRDTSDKARDPVNVFCRVRPLQSDADLTSLRVKNSTTIALNPQDQLLQHHKPHNGAQREVQYIFKHVFQPDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLRHRGIMPRCLDVLFRTISDYQAKKFVFKPDKLNGFEILSEEDALLERQHEMNQRFAGSGRFAFRHKDSDPEIASQASVEPIPLLGLDEDNMYSVFVTYIEIYNNSVYDLLEDSGIQKTLQSKIIREDANRHMFVHGVTEVEVKTVEDALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLVDLAGSERSSRTKNTGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMFKNYFDGEGQVSMIVCINPRIEDYDENMQVMKFAEMTQEVQIARATPMKQDLGLTPGRRKANKLFKIAVNNLNELGIPEAKDLEVDVGLVYSLGPDFPAYEMDSPEAQIKIRELMHYLEQRIEKRKKLRANLDIKCDSFRQMLMNLDRDNLQLRTELASLKAVYKQERDRSAALEKKVRIHESSIDVLNNTLSKQERQIEELTFKLNEKENMLTQKEHEKEKQKKKFSSKLAVESDKNKREFELKLREQRVKLQERMRIKDEKLRLVSNILQSEDLPSLPRSQSSENILNEKDRGAYTARTEESSVPATRTDIYATPRHGAAAANNRHRRSRSAGDKWLEHRAANPVPLGTIMQPYLKNRKSVTKLTDLKELTAHGTTKYCLVSQDADTDGDVETKLYKGNVIPTCGGGAQVVFNDVECLKQKSPVHSPTRKRPSNGNISALGGGAVPSTVTSAQDVASRCNLGIEGHSSKKSKI
Protein: Tesmin (Metallothionein-like 5, testis-specific) (Testis-specific metallothionein-like protein) (Q9WTJ6)
Organism: Mus musculus (Mouse)
Function: Essential for normal spermatogenesis and male fertility. Required for the completion of meiosis in male germ cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11803038, ECO:0000269|PubMed:12606435}. Nucleus {ECO:0000269|PubMed:11803038, ECO:0000269|PubMed:12606435}. Note=Predominantly localized to the cytoplasm (PubMed:11803038, PubMed:12606435). Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc (PubMed:11803038, PubMed:12606435). {ECO:0000269|PubMed:11803038, ECO:0000269|PubMed:12606435}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:31916570}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:31916570}.
Interaction partners:
- Protein lin-52 homolog
- Protein lin-9 homolog
- Protein lin-37 homolog
- H/ACA ribonucleoprotein complex non-core subunit NAF1
Sequence:
MEDALLGAMTGPEDELGAELFGSERVFADGLALSPAGGAADRDELPVLADAYLGATEPGEPLLRALSPPPGAEVPAALLGDFPGLPELRSPDDAAPPPAYSVHVLSSLLPGARGPALLPLSAGVRVIPVEIKEAGGSVPGGSPEDAAFQAPLAQESCCKFPSSQEAEEASSCPRKKDSSPMVICQLKGGAQMLCIDNCGARELKALHLLPQYDDQSSFPQSELPKPMTTLVGRLLPVPAKLNLITQVDNGALPSAVNGAAFPSGPALQGPPKITLSGYCDCFSSGDFCNSCSCNNLRHELERFKAIKACLDRNPEAFQPKMGKGRLGAAKLRHSKGCNCKRSGCLKNYCECYEAKIMCSSICKCIACKNYEESPERKMLMSTPHYMEPGDFESSHYLSPAKFSGPPKLRKNRQAFSCISWEVVEATCACLLAQGEEAEQEHCSPSLAEQMILEEFGRCLSQILHIEFKSKGLKIE
Protein: TatD related DNase (Q582X8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGFVDRGGGREAKGSSLRHSKKNPGAPAARKASSVKQQPLARVAPVPPTFRDHVQHVDASVAILSRKFGTGYSELLVRAAREGGVGAALTWCGNFEQQDALIELCRQHNAAASVLDGEEGCSKLYCLVGVHVNSVDRTHKQQQEKWMEGVVAWTRHQEVIGLLSGFSLTRDSGTHFAQEWLLKELWRKAGELQLPIVLHLCPDERDGAVVTPEDIGANGNSENMLTDGNHTVDRAAELIAELMLDQADEGGCGKEHGATRKNPTAVVLHNGVGALSCSSAMRELVRKHVPKAPSEATTGAIGRGTPPIYVLATAEGVTSSNAPGIYRPSFVHSLRNYVSLSQLLIGTGSPWNTPQNIPDEYLRTMHNEPANYQYVALAVHNAISKDVLAESPEHQEFCATVRDNFLRVFFGSSPSGKQSPQQPCDARTEEAVGEKAADKPPKPPVHFDPSIKTSSDAVKSSPESMRYYLCLKCRRKLFHERALLTHPPDAARAHFNVRQAVAGRKSALKGKHQPAVGSCDSVCFLRVVDGAEGEWCVEDSGVVVHRLNATVSCGGCGSKLGTAADDCSCPCGCVIAGTTARLAATKVEAPIGRKAGGDLDELLLEAAREREQLLLERETAGHGCGSDSDDDGEGKRKVKEAKKNVKTNNRSNFTHFRNKNFAPKQHRGHHDGSNVANVGMKDDVDKVSDGDGDGDDERRVVEDTAAGRRARRKQNKKSNRHSVSETPSE
Protein: FI17866p1 (Guanine nucleotide exchange factor in mesoderm, isoform E) (A1ZBA1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cdc42 homolog
- GTPase-activating protein CdGAPr
- Ras-related protein Rac1
- Uncharacterized protein, isoform B
- Cysts, isoform C
- Rho GTPase-activating protein 68F
Sequence:
MDIESDSDTSERWEDFFGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEESISQAKPSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPVKEPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDEEAEREREQDEDSAASLRGSKPDLSERKTKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVLKITESTEELRPDGEIELAQEAATLDESTQDQYYSPDHETELLSPAEKSKRDAQIVLDLLKNSKEFERIYNKQQKRRESPVSPVSPDISRGPILPPPRPPSRSPPPLELEEQEKKPVEEVDSVSEEPIYETLLRNVHVPYKFSPVLGRAKSSQILKKRSKTAPAASRPESDYVTLVYSPEGVLQRVGEEVVQRDSCSSSTTSTSSNGSGSTLKRDSQSTVINLLMEAAQEHESRPLPKNSVSGSESSLLPRALKSIDNLSMAFGRSNRPPERRVSDVSEMCRQSVLHRQGSEAVGERMAHVDYADPKALFGLGVLNHSERDSVFSLTSSSSDSMCEQQRKRSGVGATFEYEQQVEDSLENDFRDSAIYSDDNEKRSGDYDVHLRRPSSPPPPPPPLGPRPHQPPQIAPKPSKDQLIQQRSGVIVCQSASRSWVLQQIENFNK
Protein: CLE-1C protein (Endostatin domain-containing protein) (G5EDQ4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHLLALFIVLFLSPPAVLGGAEVFENDDFPLLSSEQEPIQPEIREFSTSPEDSSNPGTVFQVHVPRDDARVRQARASSEEREFVTQSVMLPVEIVEVIDDETAFEDDGKGAEGSGTPEEFKKTQESSELQKISDFPPTPAPPPPYPTPQLAPHDLRSYEQQAATTPFQGAPPSNQCTQVCRGEPGPQGPSGNDGIPGSHGAPGHQGERGADGAPGLHGSRGDQGLPGPPGMPGLAGPPGPPGSGTGHGSGADGPQGPPGLPGAPGRDGTSGVEGQRGPQGPPGPKGDDGVSMESLTDDDIERIARRVASIQKESNEPMRGDLPEYNSKVHSFTTKGEKGERGAPGAPGAPAPPAYGTLTTGTAVNVHATTVELFASARSTSVGQLAFATSSQQLFIRVTNGWKEIQLTHFHPFVETRHSTQNSRQNDASHAGRSRTGSAAAPWYPKANLDEPQRDAGVHNKDRVIHMIALSQPFSGNLHGLRGADLQCYREARAAGYTTTFRAMLSSNVQDLVRIVHSVDFDTTVVNVAGHHLFPSWRSFVNGAQMNPHAKLFSFDRHDVLNDSRWPDKRVWHGSKDGGIRAEQYCDGWRRADSSLTSLAGHISSNTSIFQSSGSEKCENKLVVLCVENMSKYHGDRILRLHRITSDFKK
Protein: Uncharacterized protein C17C9.11c (Q10483)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- UBX domain-containing protein 2
- UBX domain-containing protein 10
- Cell division cycle protein 48
- Wtf element wtf11
- ATPase family gene 2 protein
- Ubiquitin homeostasis protein lub1
- Pre-mRNA-splicing factor slu7
- Uncharacterized protein C577.11
Sequence:
MVLKCLECDKLLSSIEMAEFHSTKTSHDQFEETEEEIKKRSPEELKQAIEALREKAKEKKEKERILALEEKKTNYKILQKSNDETAQAMRKMQDQARLRDLQKIRQQKAEDAEQRKKILAEIERDKKRRAAERENKNSSVKETAAPIKQPKNANSSSTCTRTPPTSGRFSIRHDGQVCNITIAAEETLRQLAQQVAEKMNVSPPTKFTTTFPRASYGTDVFDKPVNQLDLFPSAVLIPQW
Protein: Kell metallo-endopeptidase (Kell blood group) (H0Y8A1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEE
Protein: Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) (Q9CPW0)
Organism: Mus musculus (Mouse)
Function: Required for gap junction formation (By similarity). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction (Probable).
Subcellular location: Membrane {ECO:0000269|PubMed:11567047}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:11567047, ECO:0000269|PubMed:25378149}. Cell junction, paranodal septate junction {ECO:0000269|PubMed:25378149}. Note=Expressed in the juxtaparadonal region. {ECO:0000269|PubMed:25378149}.
Interaction partners:
- Contactin-2
- Potassium voltage-gated channel subfamily A member 1
- Potassium voltage-gated channel subfamily A member 2
- Contactin-1
- Leucine-rich glioma-inactivated protein 1
- Disintegrin and metalloproteinase domain-containing protein 22
- Forkhead box protein P2
- Neuroligin-3
- Contactin-4
- SH3 and multiple ankyrin repeat domains protein 3
Sequence:
MVMSLRAGYRAALSLWILSSFICRAWTAPSTFQKCDEPLISGLPHVSFSSSSSLSSSYAPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDSVVRHDLQHAVVARYVRIVPLDWNGEGHIGLRAEVYGCAYWADVINFDGHGVLPYRFRNKKMKTLKDVIALKFKTSESEGVLLHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVTSGSLLDDHHWHSVLIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSNRKNFKGCMESINYNGVNITDLARRKKLGPSNMGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPSGLLLFSHFADNLGNVEIDLVESKVGVHINNTQTKTSQIDISSGSGLNDGQWHEVRFLAKENFAVLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNASYSALQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVTIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTTVVGYNPEKYSVTQLIYSASMDQISAITSSAEYCEQYVSYFCRMSRLLNTPDGSPYTWWVGKANEKHYYWGGSEPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLIPRGVFLENLGNTDFIKLELKSATEVSFSFDVGNGPVEIVVRSPSPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFKSGCSGHCTSYGANCENGGKCIEKYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAVTARDTGSRAENSADQQQHLAPDLAQEQIHFSFSTTKAPCILLYVSSLTTDFLAVLVKPTGNLQIRYNLGGTREPFNIDVDHRNMANGQPHSVNITRHERTIILKLDHYPAVGYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNHIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTETIDESKKEWLI
Protein: Activating transcription factor 7 interacting protein (F8WE35)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKETPCILSVNVKNKQDDDLNCEPLSPHNITPEPVSKL
Protein: Carotenoid cleavage dioxygenase 8, chloroplastic (AtCCD8) (EC 1.13.11.69) (EC 1.13.11.70) (AtNCED8) (Protein MORE AXILLARY BRANCHING 4) (Protein MORE AXILLARY GROWTH 4) (Q8VY26)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in strigolactones biosynthesis by cleaving the C(27) 9-cis-10'-apo-beta-carotenal produced by CCD7. Produces the C(19) carlactone and a C(8) hydroxyaldehyde. Also shows lower activity with all-trans-10'-apo-beta-carotenal producing a C(9) dialdehyde and the C(18) 13-apo-beta-carotenone. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds. Also active on other carotenoid substrates like licopene or zeaxanthin.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:16507088}.
Interaction partners:
- Carotenoid cleavage dioxygenase 7, chloroplastic
- Cytochrome P450 711A1
- F-box protein MAX2
- Protein RADIALIS-like 2
- Beta-carotene isomerase D27, chloroplastic
- Strigolactone esterase D14
- Protein HEAT STRESS TOLERANT DWD 1
- Protein RADIALIS-like 5
- Probable esterase KAI2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD2
Sequence:
MASLITTKAMMSHHHVLSSTRITTLYSDNSIGDQQIKTKPQVPHRLFARRIFGVTRAVINSAAPSPLPEKEKVEGERRCHVAWTSVQQENWEGELTVQGKIPTWLNGTYLRNGPGLWNIGDHDFRHLFDGYSTLVKLQFDGGRIFAAHRLLESDAYKAAKKHNRLCYREFSETPKSVIINKNPFSGIGEIVRLFSGESLTDNANTGVIKLGDGRVMCLTETQKGSILVDHETLETIGKFEYDDVLSDHMIQSAHPIVTETEMWTLIPDLVKPGYRVVRMEAGSNKREVVGRVRCRSGSWGPGWVHSFAVTENYVVIPEMPLRYSVKNLLRAEPTPLYKFEWCPQDGAFIHVMSKLTGEVVASVEVPAYVTFHFINAYEEDKNGDGKATVIIADCCEHNADTRILDMLRLDTLRSSHGHDVLPDARIGRFRIPLDGSKYGKLETAVEAEKHGRAMDMCSINPLYLGQKYRYVYACGAQRPCNFPNALSKVDIVEKKVKNWHEHGMIPSEPFFVPRPGATHEDDGVVISIVSEENGGSFAILLDGSSFEEIARAKFPYGLPYGLHGCWIPKD
Protein: Uncharacterized protein C576.02 (O74886)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MPTILVINPNSSTFITTSMEEKLVPLVPSDVKLRFLTCPQPGAAVIDSITEATLTAALVFQALTPSVLDGVDAIAVACYSPTPLVDMIRESFALPCMGIVQASVLSALSVGQRIGILTSTYRSECLLYELLDSFGVSRTRVAAIASTGRTVLQLSQMPSQERETLLVQKAQELANTKGADVICLGGAALAAIRDQIQVAVGPNIPIIDGVHAAVELLAGLARQNLHTSKFGIYTYP
Protein: UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (P20425)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03172}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03172}.
Interaction partners:
- Nucleoside diphosphate kinase, cytosolic
- Nucleoside diphosphate kinase, mitochondrial
- Ribonucleoside-diphosphate reductase large subunit
- Uridine 5'-monophosphate synthase
- Probable nucleoside diphosphate kinase DDB_G0292928
- Uracil phosphoribosyltransferase
- Uridine-cytidine kinase D
- Uridine-cytidine kinase C
- Uridine-cytidine kinase B
- Uridine-cytidine kinase A
Sequence:
MMEKSKPNVVFVLGGPGSGKGTQCANIVRDFGWVHLSAGDLLRQEQQSGSKDGEMIATMIKNGEIVPSIVTVKLLKNAIDANQGKNFLVDGFPRNEENNNSWEENMKDFVDTKFVLFFDCPEEVMTQRLLKRGESSGRSDDNIESIKKRFNTFNVQTKLVIDHYNKFDKVKIIPANRDVNEVYNDVENLFKSMGF
Protein: Zinc finger protein 91 (Zinc finger protein HPF7) (Zinc finger protein HTF10) (Q05481)
Organism: Homo sapiens (Human)
Function: Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1. May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidence is required to confirm this result in vivo.
Subcellular location: Nucleus {ECO:0000269|PubMed:23665872}.
Interaction partners:
- Zinc finger protein 106
- Zinc finger protein ZPR1
Sequence:
MPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWNMKQHEMVDEPTGICPHFPQDFWPEQSMEDSFQKVLLRKYEKCGHENLQLRKGCKSVDECKVHKEGYNKLNQCLTTAQSKVFQCGKYLKVFYKFLNSNRHTIRHTGKKCFKCKKCVKSFCIRLHKTQHKCVYITEKSCKCKECEKTFHWSSTLTNHKEIHTEDKPYKCEECGKAFKQLSTLTTHKIICAKEKIYKCEECGKAFLWSSTLTRHKRIHTGEKPYKCEECGKAFSHSSTLAKHKRIHTGEKPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKAFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRFHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTGEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKAFKQFSTLTTHKIIHAGKKLYKCEECGKAFNHSSSLSTHKIIHTGEKSYKCEECGKAFLWSSTLRRHKRIHTGEKPYKCEECGKAFSHSSALAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKTFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRIHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTGEKPYKCKECGKAFKHSSALAKHKIIHAGEKLYKCEECGKAFNQSSNLTTHKIIHTKEKPSKSEECDKAFIWSSTLTEHKRIHTREKTYKCEECGKAFSQPSHLTTHKRMHTGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKPYKCEECGKAFRKSSTLTEHKIIHTGEKPYKCEECGKAFSQSSTLTRHTRMHTGEKPYKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHKRIHTREKPYKCEECGKAFSQSSTLTRHKRLHTGEKPYKCGECGKAFKESSALTKHKIIHTGEKPYKCEKCGKAFNQSSILTNHKKIHTITPVIPLLWEAEAGGSRGQEMETILANTVKPLLY