wanglab/gogpt-training-data huggingface dataset:
Protein: PGL/p-HBAD biosynthesis glycosyltransferase Rv2957 (EC 2.4.1.-) (P9WMX7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in glycosylation steps downstream of mono-O-methyl-glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl-phenolphthiocerol dimycocerosate (mycoside B) during the p-hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
Interaction partners:
- Conserved protein
- GDP-L-fucose synthase
- PGL/p-HBAD biosynthesis glycosyltransferase Rv2958c
- Uncharacterized MFS-type transporter Rv2994
- Probable sugar transferase
- Uncharacterized protein Rv1520
- Conserved protein
Sequence:
MAAPMFSIIIPTLNVAAVLPACLDSIARQTCGDFELVLVDGGSTDETLDIANIFAPNLGERLIIHRDTDQGVYDAMNRGVDLATGTWLLFLGADDSLYEADTLARVAAFIGEHEPSDLVYGDVIMRSTNFRWGGAFDLDRLLFKRNICHQAIFYRRGLFGTIGPYNLRYRVLADWDFNIRCFSNPALVTRYMHVVVASYNEFGGLSNTIVDKEFLKRLPMSTRLGIRLVIVLVRRWPKVISRAMVMRTVISWRRRR
Protein: Terpene cyclase paxB (EC 4.2.3.-) (Paxilline synthesis protein B) (E3UBL6)
Organism: Penicillium paxilli
Function: Terpene cyclase; part of the ATM2 gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels. PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis. Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline. Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ. Finally paxilline can be mono- and di-prenylated by paxD.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MDGFDVSQAPPEYQAIKPLADLFVVGMGVGWIINYIGMVYISFKHETYGMSIMPLCCNIAWELVYCLVFPSKSPVERGVFWMGLLINFGVMYAAITFSSREWGHAPLVERNISLIFFVATMGFLSGHVALALEIGPALAYSWGAVICQLLLSVGGLSQLLCRGSTRGASYTLWASRFLGSTCTVGFAGLRWMYWSEAFGWLNSPLVLWSLVVFLSIDGFYGICFWYVDRNEKSLGISGPKKAN
Protein: Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) (Q9WVL3)
Organism: Mus musculus (Mouse)
Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:23376777}; Multi-pass membrane protein {ECO:0000269|PubMed:23376777}.
Interaction partners:
- STE20/SPS1-related proline-alanine-rich protein kinase
Sequence:
MPTNFTVVPVEARADGAGDEAAERTEEPESPESVDQTSPTPGDGNPRENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEDSRRREVKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVMESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTVTTALWRLFCNGSSLGATCDEYFAQNNVTEIQGIPGVASGVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHVEAQRAEENIRSLMSAEKTKGFCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEAWKEADNPFSWKNFVDTVRDTTAAHQALLVAKNIDLFPQNQERFSDGNIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTTATARTQAPPTPDKVQMTWTKEKLIAEKHRNKDTGPSGFKDLFSLKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKSRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS
Protein: Protein C3orf33 (Protein AC3-33) (Q6P1S2)
Organism: Homo sapiens (Human)
Function: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.
Subcellular location: [Isoform 1]: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:20680465}.
Interaction partners:
- Uncharacterized protein C15orf61
Sequence:
MAGQPAATGSPSADKDGMEPNVVARISQWADDHLRLVRNISTGMAIAGIMLLLRSIRLTSKFTSSSDIPVEFIRRNVKLRGRLRRITENGLEIEHIPITLPIIASLRKEPRGALLVKLAGVELAETGKAWLQKELKPSQLLWFQLLGKENSALFCYLLVSKGGYFSVNLNEEILRRGLGKTVLVKGLKYDSKIYWTVHRNLLKAELTALKKGEGIWKEDSEKESYLEKFKDSWREIWKKDSFLKTTGSDFSLKKESYYEKLKRTYEIWKDNMNNCSLILKFRELISRINFRRKG
Protein: Glycoprotein hormone alpha 2 (Q58L88)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Beta glycoprotein hormone related polypeptide
- LP13728p
- Bursicon
Sequence:
MPKPWPISTVAEMGSSQLLVLICCIPWLCDSNSMGKDAWLRPGCHKVGNTRKITIPDCVEFTITTNACRGFCESFSVPSIPMMGSSLSVLFKPPKPVVSVGQCCNMMKSEEIQRRVLCIEGIRNVTFNSALSCSCYHCKKD
Protein: L-type lectin-domain containing receptor kinase VIII.2 (LecRK-VIII.2) (EC 2.7.11.1) (Q9LYX1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9LSR8}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- GATA transcription factor 26
- Fimbrin-1
- Kinesin-like protein KIN-14N
- Transcription factor bHLH79
- Kinesin-like protein KIN-14B
- Kinesin-like protein KIN-4A
Sequence:
MLKLPPRFFSVYSTLIHILASFLCSSDVRGDFPATRFDLGTLTLSSLKLLGDAHLNNGTIKLTRELSVPTSTAGKALYGKPVKFRHPETKSPASFTTYFSFSVTNLNPSSIGGGLAFVISPDEDYLGSTGGFLGLTEETGSGSGFVAVEFDTLMDVQFKDVNGNHVGLDLNAVVSAAVADLGNVDIDLKSGNAVNSWITYDGSGRVLTVYVSYSNLKPKSPILSVPLDLDRYVSDSMFVGFSGSTQGSTEIHSVDWWSFSSSFEESSESPPPMPNSPPPSSPSSSITPSLSTVRRKTADPSSSCRNKLCKKSPAAVAGVVTAGAFFLALFAGVIIWVYSKKIKYTRKSESLASEIMKSPREFTYKELKLATDCFSSSRVIGNGAFGTVYKGILQDSGEIIAIKRCSHISQGNTEFLSELSLIGTLRHRNLLRLQGYCREKGEILLIYDLMPNGSLDKALYESPTTLPWPHRRKILLGVASALAYLHQECENQIIHRDVKTSNIMLDANFNPKLGDFGLARQTEHDKSPDATAAAGTMGYLAPEYLLTGRATEKTDVFSYGAVVLEVCTGRRPITRPEPEPGLRPGLRSSLVDWVWGLYREGKLLTAVDERLSEFNPEEMSRVMMVGLACSQPDPVTRPTMRSVVQILVGEADVPEVPIAKPSSSMSFSTSELLLTLQDSVSDCNEVLAPISTTSCSSSEHDIFIVGKDRSV
Protein: Serine/threonine-protein kinase mos (EC 2.7.11.1) (pp39-mos) (P12965)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P00540}.
Interaction partners:
Sequence:
MPSPIPVERFLPRDLSPSIDLRPCSSPLELSHRKLPGGLPACSGRPRLLPPRLAWCSIDWEQVLLLEPLGSGGFGSVYRATYRGETVALKKVKRSTKNSLASRQSFWAELNAARLRHPHVVRVVAASASCPGDPGCPGTIIMEYTGTGTLHQRIYGRSPPLGAEICMRYARHVADGLRFLHRDGVVHLDLKPANVLLAPGDLCKIGDFGCSQRLREGDEAAGGEPCCTQLRHVGGTYTHRAPELLKGEPVTAKADIYSFAITLWQMVSRELPYTGDRQCVLYAVVAYDLRPEMGPLFSHTEEGRAARTIVQSCWAARPQERPNAEQLLERLEQECAMCTGGPPSCSPESNAPPPLGTGL
Protein: Merozoite surface protein 3 (A0A7D5SLD3)
Organism: Plasmodium falciparum (malaria parasite P. falciparum)
Interaction partners:
Sequence:
MKSFINITLSLFLLHLYIYINNVASKEIVKKYNLNLRNAILNNNSQIENEEKDIKYELNEQNDENVNTPIVGNSMEFGGFTADDEKDMEAYKKAKEASQDAEKAAEEAEKAAEQAGQASKDAEKLKESDESYTKAKEACTAASKVKKAFETASNAKKAAESALKTNETGERNSRNNFYTTKTKEYAGKVEKDYERAKNAYQKANQAVLKAKEASSYDYILGWEFGGGVPEHKKEENMLSHLYVSSKDKENISKENDDVLDEKEEEAEETEEEELEEKNEEETEEEELEEKNEEETESEISEDEEEEEEEEEEKEEENDKKKEQEKEQSNENNDQKKDMEAQNLISKNQNNNEKNVKEAAESIMKTLAGLIKGNNQIDSTLKDLVEELSKYFKNH
Protein: Somatotropin (Growth hormone) (P34745)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Function: Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.
Subcellular location: Secreted.
Interaction partners:
- Growth hormone receptor
- Growth hormone receptor-like.
- Prolactin receptor
- Ghrelin
- Prolactin receptor
- Prolactin
- Proopiomelanocortin
- Prolactin-like.
Sequence:
MARVLVLLSVVVASLLFSQGATFESQRLFNNAVIRVQHLHQLAAKMMDDFEEALLPEERKQLSKIFPLSFCNSDSIEAPAGKDEAQKSSVLKLLHTSYRLIESWEFPSRNLGNPNHISEKLADLKMGIGVLIEGCVDGQTGLDENDSLAPPFEDFYQTLSEGNLRKSFRLLSCFKKDMHKVETYLSVAKCRRSLDSNCTL
Protein: Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) (P19623)
Organism: Homo sapiens (Human)
Function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.
Interaction partners:
- Ornithine decarboxylase
- Guanidino acid hydrolase, mitochondrial
- S-methyl-5'-thioadenosine phosphorylase
- Diamine acetyltransferase 1
- Spermine synthase
- Diamine oxidase [copper-containing]
- Thialysine N-epsilon-acetyltransferase
- Alpha-aminoadipic semialdehyde synthase, mitochondrial
- Antizyme inhibitor 2
- Arginase-2, mitochondrial
Sequence:
MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS
Protein: Uncharacterized protein PB2B2.06c (Q9HDU9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized transporter C36.03c
- Putative inorganic phosphate transporter C1683.01
Sequence:
MKTASIHFWSTLVLLFSCIGSVIAYSSTDLTTMYDWNQIIKPLEWGQMNFIHTTDTHGWLNGHLRDARYKADFGEFKSFVLRMKELADFKDVDLLLVDTGDLHDGNGLSDASDPEGIYTNNIFTYLPYDILTIGNHELYQASVSNNTHEYFVPHWNGTYLASNVQIFNSSNELEQFAAESAYFTTKHGVRVLAVGFLYDFTGNANNTVVTPVETAVNSRWYQQQINRTDVDLFLLLGHIPVRDWDEWKSLHASIRKVHPDTPIQIFGGHSHIRDFAVYDESSVSLEGGRYCETVGWLSIDGLAASNATRQYVGRPVTNETRQSYPNLPIPNTPLYYTRRYIDFNRQNFRFHTQQSEDSFDTPEGIELSKIIKQYRDDLNLSYVFGCVPKNYYMTEVSPQSDDSIFKLMTDRVLPEIITNRNRSTVPRIIISNGGGIRGSMYQGKFGPDEMFQLNPFLTNYYMYLADVPYKYAKKLYSTLNGGSNLRNINENLAALNPGYVTSDDFGEDGDDTVHTSVPSYATPNILQAQAGFNATSSPETIDVVFLNFLQSIVLKALNNMANDTLYTSSNVTQYWVRDDGYDSSPYSFAYFVQQEWSDNCD
Protein: Actin-related protein 3 (Actin-2) (Actin-like protein 3) (P61157)
Organism: Bos taurus (Bovine)
Function: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P61158}. Cell projection {ECO:0000250|UniProtKB:P61158}. Nucleus {ECO:0000250|UniProtKB:P61158}. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes). {ECO:0000250|UniProtKB:P61158}.
Interaction partners:
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 1B
- Actin nucleation-promoting factor WASL
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 5
- Actin nucleation-promoting factor WAS
- Actin-related protein 2/3 complex subunit 4
- Src substrate cortactin
Sequence:
MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
Protein: Armadillo repeat-containing protein 2 (Q3URY6)
Organism: Mus musculus (Mouse)
Function: Required for sperm flagellum axoneme organization and function. Involved in axonemal central pair complex assembly and/or stability.
Interaction partners:
- Tetratricopeptide repeat protein 21A
- Sperm flagellar protein 2
- Cilia- and flagella-associated protein 43
- Glutamine-rich protein 2
- Cilia- and flagella-associated protein 69
- Cilia- and flagella-associated protein 44
- Cilia- and flagella-associated protein 251
Sequence:
MLSSNDQKLEKLDSFYRPPVSKQRTSAEIISEARNALRTVRTQRPFTPREDQRKLFGPASSRSPENRPPSSFSLHASSFELSDSKPISGTRLRPLELKPKAPASPGTEDACLSFPKAPLDPAKIRKISGARARFYRAASQGMLLPDRSPPAAHSKTVDESSKPVSVGSSTARRNGTHLTASSATGQLKSPPLLTCDQGFQETTEQEVSLLSQLRRGGDPGKRRARASSCPSSSDLSRKETRAASRASSQEQETDTEVDEVFWKARIVPILHELENEEDIEEMCAACTQLHRTLEEARMLGKKFKRRTVLLKALYKLVDADSDPLSLKLAKLILALKVSGKNLLNVCKLIFKISRNEKNDTLMQEDNILESLLEVLRAEELQSNTEAFLYCMGALKFVSGSPGFLTEMVNKGAVEILAQLIKEMTEDTEKHGVCLPDSGHLLVQTTATLRNLVDSPLTRSKLLNMGAFPHLCTVMEQHADDKDICTNIARIFSKLTSYRDCCAALASYSRCYALFLSLLNKYQKNQDLVIRIVFILGNLTAKSNQARELFSRETGSVETLLTLFQSFYHHKENSPKLQLSEAKPQAEAEDVLVKLTRVLANIAIHPRIGPVLAANPRVVGLLLRTLESKSLGDCEELVINTIAAINNLSFYQVKSSVLQHRKLYVAELLLRLLVSNNMERILEAVRVFGNLSQDHDVCNFLMQKNVHKFMITLLEAKHQDICFSACGVLLNLTVDKEKRAILKEGGGIKKLVDCLRDFGPSDWQLACLVCKTLWNFSENITNASECFGDDVANTLLILLSTFLDEELALNGSFDQDLESYHRLHWETEFKPVAQQLLQRIQSHHSLLEPLPVPSF
Protein: Partitioning defective 6 gamma (A3F6Q3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYQLVVHTHHISNTEVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEADHYSFGAGTLSRKKKVLVTLRDEGLRRRAQLNISMPHDFRPVSSIIDVDILPETHRRVRLYRHGCEKPLGFYIRDGTSVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRSSRASGSSVQSTDSTTSHHSLPGTHALQNSEEMESDEEADIVIEGALEPHHIPKMQAVPPGSLSRANGASLAHRLHRGDGGLHSSGRESNGSIHRFLSSLKPDPRHSLVLPQGGVEEHGPAITL
Protein: Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican) (P51884)
Organism: Homo sapiens (Human)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Decorin
- Fibrillin-1
- Tumor necrosis factor ligand superfamily member 6
- Fibronectin
- Collagen alpha-2
- SPARC
- Collagen alpha-2
Sequence:
MSLSAFTLFLALIGGTSGQYYDYDFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVSAAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGNRISETSLPPDMYECLRVANEVTLN
Protein: Epsin (Q54EH1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
Subcellular location: Membrane, clathrin-coated pit {ECO:0000269|PubMed:18827012}.
Interaction partners:
- Clathrin heavy chain
- ANTH domain-containing protein
- AP-2 complex subunit alpha-2
- Clathrin light chain
- AP-1 complex subunit gamma
- AP-1 complex subunit beta
- AP-2 complex subunit mu
- AP-3 complex subunit delta
- Epidermal growth factor receptor substrate 15 homolog
- AP-3 complex subunit beta
Sequence:
METMIKSYIKKGKDAVLNTPEIERKVRDATSNDKWGPSGTQMQEISRASYNYECFPIIMGVIWKRINDPGKFWRHVYKSLLLIDYLVRNGSPQVIRDCRHHTMEIKTLVEFQYIEEEKDVGLSVRERAKQVIDLLQDDQRIKEERDKAKTNQNKYVGIGNDSRDFGYGGGSYGGGGYDSDSYGSNQRDSYGGNQRDSYGGNQRDSYGGNQRETTRRDSFNGRDEGYGNNNNNNNNNSYDSDPYSNTRAEYENYSNRAETRRNNEFGDDSNNSYNNNNNFNNNNNNNNSYNNSNNSNNSNNNNNNNNYNNSNNNSNNIQNNPNAASGGRSRPRAASGSGPSPATPNFQSSQQQQQPTLIDFSEPTPANKPMVFDPLADLASGMNNTNNNNNNNNNNSNSFGGFQSVNNNQNSFNFNNNNQQQQQQNNFLQLTQSNPQQSNNNNNNNNFFNQQPQQAQQFGQFQNSSMNKDPFAKDEFGDFAGANGNADFNPFDQQSGDFSNKNDGQQKPKDTNDPWSKKDLFDLSNLGNQNPNQSPVNNTNNNNNGNTRSQPARVANGPITSAGSTIPTMRPQPMMNQGFNGGMMNQGMGGFNQGGGMNNMNGMNQGGMNNMNGMNQGGMNQGGMGGFNQGGMNNMGGMNQGGMNNMGGMNNMGGMNSMNGMNQGGMGFNQSGANRNTNSMGSAGRF
Protein: ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) (Q9WUA3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
Interaction partners:
- Glucose-6-phosphate isomerase
- Fructose-bisphosphate aldolase A
- Hexokinase-1
- Hexokinase-2
- ATP-dependent 6-phosphofructokinase, muscle type
- Fructose-bisphosphate aldolase B
- ATP-dependent 6-phosphofructokinase, liver type
- Fructose-bisphosphate aldolase C
- Hexokinase-3
- Hexokinase HKDC1
Sequence:
MSDLDSSSSSAYPKYLEHLSGDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAFRSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRARKKRLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETPACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSINALLIIGGFEAYLGLLELAAAREKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVAELKKVTDFEHRIPKEQWWLKLRPIMKILAKYEASYDMSDSGKLESLQHHEEL
Protein: Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9) (Q9NTK5)
Organism: Homo sapiens (Human)
Function: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm. {ECO:0000255|HAMAP-Rule:MF_03167}.
Interaction partners:
- BRCA1-associated RING domain protein 1
- Peptidyl-tRNA hydrolase
- Malignant T-cell-amplified sequence 2
- Breast cancer type 1 susceptibility protein
- Ribonucleoside-diphosphate reductase large subunit
- Malignant T-cell-amplified sequence 1
- Tyrosine--tRNA ligase, cytoplasmic
- Heat shock 70 kDa protein 4
- Arginine--tRNA ligase, cytoplasmic
- Probable arginine--tRNA ligase, mitochondrial
Sequence:
MPPKKGGDGIKPPPIIGRFGTSLKIGIVGLPNVGKSTFFNVLTNSQASAENFPFCTIDPNESRVPVPDERFDFLCQYHKPASKIPAFLNVVDIAGLVKGAHNGQGLGNAFLSHISACDGIFHLTRAFEDDDITHVEGSVDPIRDIEIIHEELQLKDEEMIGPIIDKLEKVAVRGGDKKLKPEYDIMCKVKSWVIDQKKPVRFYHDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKDYIRKKNKWLIKIKEWVDKYDPGALVIPFSGALELKLQELSAEERQKYLEANMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFNTPQQPKKK
Protein: Dynein light chain Tctex-type 4 (Protein N22.1) (Tctex-2-beta) (Tctex1 domain-containing protein 4) (Q5JR98)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:23789093}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:23789093}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23789093}. Cytoplasm {ECO:0000250|UniProtKB:Q8CDY7}. Nucleus {ECO:0000250|UniProtKB:Q8CDY7}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:23789093}. Note=Present along the entire length of the flagellum, including principal and endpiece, and more predominantly in the midpiece region. {ECO:0000269|PubMed:23789093}.
Interaction partners:
- Dynein light chain Tctex-type 1
- Dynein light chain roadblock-type 2
- Dynein light chain Tctex-type protein 2B
- Dynein light chain roadblock-type 1
- Dynein light chain Tctex-type 3
- Cytoplasmic dynein 2 intermediate chain 1
- Cytoplasmic dynein 2 intermediate chain 2
- Cytoplasmic dynein 1 intermediate chain 1
- Cytoplasmic dynein 1 light intermediate chain 2
- Dynein light chain 2, cytoplasmic
Sequence:
MASRPLPPGRQEEENAKDSGRKPSPVRPRGCLPSIDEARPAGPGPAPASRRGSMLGLAASFSRRNSLVGPGAGPGGQRPSLGPVPPLGSRVSFSGLPLAPARWVAPSYRTEPVPGERWEAARAQRALEAALAAGLHDACYSSDEAARLVRELCEQVHVRLRELSPPRYKLVCSVVLGPRAGQGVHVVSRALWDVARDGLASVSYTNTSLFAVATVHGLYCE
Protein: MIF4G domain-containing protein (SMG-3) (G5EDT8)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MRRKVETSWLEELKKRVKYQETSRLQMVEIRETLLDNEKELRSLDSTLKKTTSFMKKVKLLSAATVPQLIEELSKLNLSKFVEEMASGIIETKLKLSDIPKVTELCLAISAKYSNFSEQMAGEFKKVLPVKKSDKIANVAKLRVDIIFLAELCLCGVFNEKEGLQVLGAVLSYLIQTDKTDFVNVGLLATVSRTVGWQIANIVPIPMDDAETVEIQDEELPESSALSVEQKKSIRELFKSYYDSLYSKTEKTCSARNKAMKRVKRQERSRGDAGDEEKTTLNDLQSELDSLRKMAIEISSAIGVEMKPLKEEASDDEEDEAANLEMGRKLAEGAIKLWSDEETKAFYEDLIDLRQMVPKDLYKESEQRTLSKAKMAERIEDVDMENINESGAMDAKRSSLQRGESEKETTPEDSQLQALLKEAVDASEERGVSKWQSFVLDLDHLVSKYSTDQAAIYFVSNLNNKGCRKRLVKLMIDPPPSRIDVVPFYARLVATLENVMPDLTTEIVTQLLEKFRGFLQQKPSSATAIIKVESKMVCVMMIAELMKFGVISRAEGLSCLRQLVYDLRGHSVEMTATFMESSGLYLYRHTESHAKMKRLLEVVKAKRERMKDQRQAMLIDNAYFTCLPPEDSKEERLRLKLDEEDTPMKRFIRHIILDINESTVDVFLKCLRRLEWYDPEVADYAIRYLSSTWLLPIENLQHVASAIAGLCNLVHLQWIGMAVIDSTIETIRISLENPGVYNQWAHSAAVYLAELYSFELCDEDLVLKILYQLISYPEPENSWRDLHRIRMICAMLEILREFFMKGSGKIKMRYFLSYFHRYYYIKKDAWDQEVAEQQPNSGGETGENQNPLDVQTSFPYEVELAYTELCRQFRQKKSNSLRWPKNLKEAQDIVTKIEKKFKGELKEFAGEHKDIEGDGLNELNVIEEDDEEDEDENRDSELDEDDSEEDRQKIENFSNAVTKEEDDEFQRELDRMMGEGFRQSAMPVAAAQYDVTLPAAVKDRFNRSIKFAETVKDEPAASSSKQDNDDDEDVYEKSPTIAASGRQKQTRVTLMVRGKTNKPSLKTVNIDDDQLQERWKEEKAREEQERADMKRLTLGQHRRIEMEEEKALLASLNSSRKGNAKRGQFRPQFPKPHLEGEW
Protein: Prestalk A differentiation protein A (Q54LW0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in development and cell differentiation.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- NADH-ubiquinone oxidoreductase 23 kDa subunit
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase subunit 9
- NADH-ubiquinone oxidoreductase 49 kDa subunit
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- Cytochrome c1, heme protein, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4
- NADH-ubiquinone oxidoreductase 75 kDa subunit
Sequence:
MQTNITSTKMSILVTGGTGVVGRQVVKSLELREKNINIRVGGRDQDKCNQLGFGKNSTFTRFDFMDPTTWDKSLEGVDRVFLIALPMDPTPEKSLGPFIEKCKERKLKKIVVLSVIDAERVPLVKIEQMVQGSGLTFVILRPPFFSENFSEGFMKHDIDQGTIRVPVGEHSVNWISTHDIGECASIVLMDSKFDGRTIEITGPKPINFKELSEVVSKNVGKQIRFEDIKPQEYKKCLMDRGISEPSANYLNELFTSAREDKLSKCTKGVNEITGHDPRSFEQFAKETFSNTSGSCTSKPVI
Protein: Thyroglobulin type-1 domain-containing protein (G1NGG4)
Organism: Meleagris gallopavo (Wild turkey)
Interaction partners:
Sequence:
MSWCLRLAESCPVAHICFGALQKDGDNGDDRSESILAENHVDSTGGMLSGASSRKPIKTGMKELAVMREKVNEQQRQMGKVGKAHHNHEDSKKSRMPTGRTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSVNGQRGECWCVDPIHGKVIQGAPTIRGDPECHLFYTAHEQEDRGAHALRSQ