wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (G8B5J8)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
- glucan endo-1,3-beta-D-glucosidase
Sequence:
MKFSDTFVLAFAACAIAAPAPAPGANANAAYKNHAVVPKAAKRDAAQEDCQEPVFHGHHKHKRAVVYEYAYVTVTVDAKGNPVTTTATTLTESTGDAQETGNTSSEISSTTTIVQDHSLTSNEPSTLSLPSGTITPSTSSSEASSTGGSSSPPSSSNGINGDLSAFENPSEEFPDGVYSCDYFPSGQGVIALDHLGFGGWSGIYNSDTSTGGSCKEGSYCSYACQSGMSKTQWPDNQPSNGVSVGGLLCKNGKLYKTNSRSNYLCEWGADKANVVSKIDKSVAICRTDYPGTENMVIPTVVDAGSTSVITVVDQDTYYRWRGGATSAQFYVNNAGVSYQDGCLWGSAGSGVGNWAPLNFGTGYAGGVAYLSLIPNPNNYDSLNFNVKIVAADDSSNVSGQCVYENGKYNGNGKDGCTVGVTKGKGNYVLYN
Protein: Enhancer of rudimentary homolog (P84090)
Organism: Homo sapiens (Human)
Function: May have a role in the cell cycle.
Subcellular location: Nucleus {ECO:0000269|PubMed:23145069}.
Interaction partners:
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein G
- Protein arginine N-methyltransferase 1
- Chromatin target of PRMT1 protein
- Protein arginine N-methyltransferase 5
- Small nuclear ribonucleoprotein-associated proteins B and B'
Sequence:
MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFIDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK
Protein: DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha) (Q9NG98)
Organism: Drosophila melanogaster (Fruit fly)
Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Weakly relaxes negative supercoils and displays a distinct preference for binding single-stranded DNA.
Interaction partners:
- RecQ-like DNA helicase Blm
- DEAD-box ATP-dependent DNA helicase Fancm
- Replication protein A 70 kDa DNA-binding subunit
- GEO08380p1
- ATP-dependent DNA helicase Q4
- Survival of motor neuron-related-splicing factor 30
- CG9273 protein
- DNA repair endonuclease XPF
- Crossover junction endonuclease MUS81
- DNA topoisomerase 1
Sequence:
MKAVLTCFRPVVASHRRYCANPGQAMKYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHMMQLAFQVSYKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDCDREGENIGYEIIDVCRAIKPNISVYRATFSEITTVAVRRALQQLGQPDKRQSDAVDVRTELDLRTGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPTLGFVAERYKEIEAFVSEPFWKIKVLHTIDDLTVEFNWARNRLFDKEACENYLLLCLAEPDPRALVESVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAKETMTIAEKLYTKGFISYPRTETNQFSKEFALAPLVEMQTGHRDWGAFAQRVIEWGPNPRNGNKSDQAHPPIHPTKLAENLQGNEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNYLDVYVYDKWSAKQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALMEKHGIGTDATHAEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELALAKPQLRAEFELDLKLICQGQKDPKVVLTEQIAKYKQAYQQITDKITAMDAKISARINETPAANSAVQEGADGSAPSHGIIQSIFQCPKCNEAPLALKPKKNQQGWYIGCNNFPDCKNAVWLPTECKDASVLDECCPTCGDGYRMLKFRLSTPYYRGVFGTPSGWYKTCLPCDNLFRTTFNINLDSVKKVGGIVGEVRGGGGGPGPGPGGGGSGRGAGSGGWSSGPGGGGSGGGGGSGGWGSGTGGGGSGGWGSGTGGGGLGGGKGKKPGGESKKSATKKPPNEPKPKKTKEPKAAPNKKTSSKSSGSIRSFFTSAAPTNSASNGLDEFFDSNDGFEDAMLAAAESVESSSQPKTISMVPLDDDIAAAFAADDDAEFEALVNGGTMPTESNGDQQLDKSLSEWIKEQDKADERPMLWGTRERASLGTAAPTPPPKPAAKRPRWDSVERDSTPPSSVPESETVLCTGCQQPARQNTVRKNGPNLGRLYYKCPKPDECNFFQWADEPPSSAKSKNSTGSAPQSTTSWGSNRVVTLPSIQQSNSQRGQSSMRSNSSSTVTITQTKTKQQERNTATPGDGEEVMCNCGQLASQLTVRKDGPNQGRPFYACPTREKSCGFFKWGDEDQNQGASSTSWGSANRNPPGRSQPTAITSDGPKTRRCGLCRKEGHTRNKCPRKDEFDM
Protein: Glycosidase superfamily protein (Q54X80)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MNKFLFTLLILSIFLNIIKCDQTLLIRSINKTINFSDFLGIGGEFSLFSSDIVSQQLTYIKQLPIGWVRIGIPFDQFESTEGVFNLNRFDPPMRQLNASGLNTIVYFTGVPSWFNTVGPTPTPTPLDPSTVPSTIEQQTQFAQTLLNLAKNYTFVKYWQVWDKMNDIPTGAQSYDPQNYLDLYQEVLTVFKSEGLQNKLSIGSVLNYGESTAPGSNANFITDLLSEDGAGPNILTTISTSSFQPYTTYPEGNDLSDISSDNSNYILSNNLVNKLKSSPTSSSLVFSSEWGWSSDASLGGEVQQANNTIKRLLLDTVNGVDKSFLYTISDLDTNSNITTASDRLFGIVNLQLGKKLVYRVLERLFQIIGTQLVPPTELNAISTTGVQPGMVILLFKKPTTNTFLIVFYKNYLSPANGGPNDPYTNVSTVTLFGAIPNGGNKENVGYLYTPINVNQSPSTASAYQVISYNKDGSFYLPVSHDLSILEFPLPPPKNNSDSSSDQDSNSLKLSPQFSILIIFTLSLIFQFIF
Protein: Esterase LipC (EC 3.1.1.-) (P96402)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits pro-inflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immune responses.
Subcellular location: Cell surface {ECO:0000269|PubMed:22038913}. Secreted, cell wall {ECO:0000269|PubMed:22038913}. Secreted, capsule {ECO:0000269|PubMed:22038913}. Note=Cell surface protein that is present in both the cell wall and the capsule. {ECO:0000269|PubMed:22038913}.
Interaction partners:
- Possible esterase LipW
- Putative diacyglycerol O-acyltransferase Rv0221
- Putative hydrolase LipZ
- Probable conserved transmembrane protein
- Uncharacterized MFS-type transporter Rv2994
- Esterase LipU
- Triacylglycerol lipase
- Carboxylesterase/phospholipase LipF
- Probable conserved transmembrane protein
- Enoyl-CoA hydratase EchA19
Sequence:
MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHLKPLGGVTAIGVWGARHASDFLSATAKDLLTPGINEVRRRDRASTQEVSVAALRGIVSPDDLAVEWPAPERTPPVCGALRHRRYVHRRRVLYGDDPAQLLDVWRRKDMPTKPAPVLIFVPGGAWVHGSRAIQGYAVLSRLAAQGWVCLSIDYRVAPHHRWPRHILDVKTAIAWARANVDKFGGDRNFIAVAGCSAGGHLSALAGLTANDPQYQAELPEGSDTSVDAVVGIYGRYDWEDRSTPERARFVDFLERVVVQRTIDRHPEVFRDASPIQRVTRNAPPFLVIHGSRDCVIPVEQARSFVERLRAVSRSQVGYLELPGAGHGFDLLDGARTGPTAHAIALFLNQVHRSRAQFAKEVI
Protein: Filamentous growth regulator 41 (GPI-anchored protein 35) (Q5AP52)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Putative adhesin which may be involved in cell adhesion and virulence (By similarity). Involved in the regulation of filamentous growth.
Subcellular location: Secreted {ECO:0000269|PubMed:20641015, ECO:0000269|PubMed:21622905}. Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Pga38p
- Chitinase 3
- Glucan endo-1\3-beta-D-glucosidase
- Glucan endo-1,3-beta-D-glucosidase 1
- Protein DSE1
- Uncharacterized protein
Sequence:
MKISNLIPAYLLPFSLFCQVLGAPTNGKRGNVVVVKVKTTVQQTQTDIQTISEATGTTTNYLINTSTETFTRYTATVTSTVYGVPHTYTTVATTPVSAADVIPNSENEVKSSPTESPVEQETSTSSTSVATTTTPVAKNPVSSQETSTPTPVPPETTSTSSSLLSSSQQTTTLAQVSETAINDTTESSGPTITGSVSSQTTDSWIIENISTVTSDGTCFVNYDYYYATETDDAEETTTLTSTITTTVTLN
Protein: Zinc finger protein 23 (Zinc finger protein 359) (Zinc finger protein 612) (Zinc finger protein KOX16) (P17027)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation. May have a role in embryonic development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- NADPH oxidase 4
Sequence:
MLENYGNVASLGFPLLKPAVISQLEGGSELGGSSPLAAGTGLQGLQTDIQTDNDLTKEMYEGKENVSFELQRDFSQETDFSEASLLEKQQEVHSAGNIKKEKSNTIDGTVKDETSPVEECFFSQSSNSYQCHTITGEQPSGCTGLGKSISFDTKLVKHEIINSEERPFKCEELVEPFRCDSQLIQHQENNTEEKPYQCSECGKAFSINEKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITHQTIHSGEKPYQCKMCGKAFSVNGSLSRHQRIHTGEKPYQCKECGNGFSCSSAYITHQRVHTGEKPYECNDCGKAFNVNAKLIQHQRIHTGEKPYECNECGKGFRCSSQLRQHQSIHTGEKPYQCKECGKGFNNNTKLIQHQRIHTGEKPYECTECGKAFSVKGKLIQHQRIHTGEKPYECNECGKAFRCNSQFRQHLRIHTGEKPYECNECGKAFSVNGKLMRHQRIHTGEKPFECNECGRCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSINAKLTRHQRIHTGEKPFKCMECEKAFSCSSNYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQRSHTGEKPFRCVECGKGFSFSSDYIIHQTVHTWKKPYMCSVCGKAFRFSFQLSQHQSVHSEGKS
Protein: Nucleic acid binding protein, putative (Q383X8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nucleic acid binding protein, putative
- Poly
Sequence:
MSEAIEGGPTSACGGRTGREQIHQANSLVRCSICGNVGHDKVACLSARKRPRTEEEEEALPSVCRSCGSSRHAEASCPLRMKSMECFQCHQKGHLLPMCPQTRCYNCGNYGHSSQRCLSRPLCYHCSSTGHRSTDCPLREKGRVCYRCKKPGHDMAGCSLSALCFTCNGEGHMSAQCPQISCNRCNAKGHVAAQCPQASGNRSNVKGNVVVACSKFPSVASGGSIPTVDWKRNFPTSAASGDENVVNDWSPDREEDGVDATPHAATVVSGRREIIPPFVASGAKRDGKVAVIVDGGYFERLLKGHEFRDEEQYKRCVEALRYVLDFIGEIFQKTSVAFWFDTDPSAFADYVENSMSLIHREKAFRGNSLRKRVLLDEMNGGRKLSNVVARLVGRMKRQKGYTGDGPGYVWVQTGVDVAIATCVIETFLRRQFDQVVLLCGDSDVYPAVSFCQEQRRTLQTADGPNPVRVCGTSSSISQLYGQDQDLCDFLPQILLDAPSHTEGNRTVDFPTHSVFQ
Protein: Jasmonoyl--L-amino acid synthetase GH3.3 (EC 6.3.2.52) (Auxin-responsive GH3-like protein 3) (OsGH3-3) (Indole-3-acetic acid-amido synthetase GH3.3) (Jasmonate-amino acid synthetase JAR2) (Jasmonic acid-amido synthetase JAR2) (Protein JASMONATE RESISTANT 2) (OsJAR2) (Q5NAZ7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Catalyzes the synthesis of jasmonate-amino acid conjugates by adenylation. Catalyzes the conjugation of jasmonate (JA) to Ile when expressed in a heterologous system (E.Coli). Catalyzes in vitro the conjugation of jasmonate (JA) to Ile, Phe, Leu, Met, Val and Trp. May catalyze the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin (By similarity).
Interaction partners:
Sequence:
MLEKKATRSTRVDGVSGEAVIEEFERVTRDAANVQRETLRRILAENGGVEYLRGLGLAGATDPATFRARVPLATHADLEPYIDRIADGDASPVLTAKPATSISLSSGTTQGKRKYLLFNEELVKSTMQIYRISYAFRNREFPVENGKALQFIYSSRETRTKGGLTATTATTNVYRSEEFKATMRDIQSQCCSPDEVIFGPDFAQSLYCHLLAGLLAAGDVQIVSATFAHSVVLAFQTFERAWEDLCADIRRGEVSPSRVTSPAVRRAMAALLAAPNPGLADEVARKCAALSNWYGVIPALWPNARYVYGIMTGSMEHYVKKLRHYAGGLPLVAAEYGASEGWVGANVEPGTPPERATFTVLPDIAYFEFIPLKPVAGDGGYAEAEPVGLTEVAAGELYEVVMTTFAGNTRSSSSCMTLVAYYYLQSKKWMNICRFCISVHETSRNLVTCTFAATGHIMFAQK
Protein: Tusp, isoform F (A0A0B4KI44)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MHLHFERNINTKCDCTILSLSWMGKVPDDIPEDEGWKLNRTNYYQEGWLATGNVRGIVGVTFTTSHCRKNMDYPLRTNYNLRGHRSDVILVKWNEPYQKLASCDSSGIIFVWIKYEGRWSIELINDRNTPVTHFSWSHDGRMALICYQDGFVLVGSVAGQRYWSSMLNLESTITCGIWTPDDQQVYFGTTQGQVIVMDVHGAMVSQVQLSNDVPITSMAWSCEKFKMEEGEEAEPGVTNAAKRSFVLAVSFQNGYIYLLKSFDDVSPAHINTCLNGALGMVMEWSNSRELLAVAGTLRTGVDGTKTEDMGTPSCYTNLVKFYTETGTCLYQAHIPCSSATVSAITWGHNDKRLFIATGTQVHIAWVSRRVASLQLLCRLEIQASVGSESLLPLLPLPSRIKSLIGNLFAQTIRCCVPDLKSLRDFVSRPPLCSTRLHCTMIRHDDDSNLSSGTCYTLYLEYLGGLVPLLKGKRTSKIRPEFVIFDPQVNDSPLYFQYSAEAKSSSGSSQSTTTGNSGRTDSSDSDFEERSRFGSPRTPRKKRVRPKRRHQAGDRLSASGGGVSNDPDSLDELAYVDTLPEQEVKLVEVTSNIWGTKFKIHGLAKTVPANLGQVTYKTSLLHLQPRQMTLVITELRDDFPPGPDPSFNPNIFSEDEDEHHQHQGIHHDAVPQVNVITAQDGASLKPPIIPQRRLTDGASAPLIAPMSPRPNRILARHKNSLTVNGERGSGSSAGLSPLARAESYDDDSSNESQEAGAAGSQSTTVLLHQAPSNGSGPGPSCSKSITRPKTISSFKNSYSRSSSNSSCQSRHAISPLYCDGAVPTLQSPKNAVAPSDIIFERPAVPAAGQTTLMSYSSNADYANNVVQVKNALMSEPVRSANSHVNPVPLNLNLNLERMDARVKCTAPTTSSTAKRREMLYIDEETQSPTPTPSSSSMKRTPTVVSIAPALPDSITRSCSVGYLDSVAITPSDEALSALRKDAPNKRLILVDKKRNRRKRQQQEDARRHKLQQTGKSKSLDSCDLLSLQTKLSSKEHEQVVRKLQEISDSSACSSAANTLCFKCRNNMSPSSACKRCQPSASSVLDEITAVVPAVEPAKESPAVQAKPAPKKRFDVITSFTDSPLFTRKHRFGIGRSKETAGTENSTPLLGRKQDNGFSFVKQLSEVRWRRKEQPAQAQVNGSSNASTLERQPQPEITGAACGTVEATPVEAKASVSLHTQALTTLENIISRLRDLDEGRLTPPSTPQRLPRSSPASPAASKKNKRQQSNSPIRHILNSPLLNRRQRKKQSIIESSDDEGNQTNGSGEESNNAGNGKQYRDLETFQKAQLRQKLKRGKIEPNGSASCANPAPVRREFVMHNKAPMWNEMSQVYQLDFGGRVTQESAKNFQIEFRGKQVMQFGRIDGNAYTLDFQYPFSALQAFAVALANVTQRLK
Protein: Glyoxalase I-like protein GILP (EC 4.4.1.5) (C6KSP5)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- hydroxyacylglutathione hydrolase
- hydroxyacylglutathione hydrolase
- Lactoylglutathione lyase
- NADH-cytochrome b5 reductase, putative
- FAD-dependent monooxygenase, putative
Sequence:
MKLFVVVIFVLFILLKRYKCLSKKKNRCHYFINRDSYHLKKKKCKRKILKCKVDGIEYKVHDLDKSINFYTNVLNFKVNKKEKDNAQLILGDDGAYIKLIQKGEGNFTIGEHSFLGLGVHLKNFDINKTKLYEGKIDEEIDKRPVTPCILPDEDAQVRRFWTNCFITDPDGYGIEVVLQNESDKLDRIRFFTTSTKDAQKFYSDILGMQLVKIQSHLEEISYPWNIYGGMSYYFSSENNSTILQMAYAYDEEELHMGNSLGNLILCSKNLNLIEKKLNENNIEVIKNDKGEILVKDLDGYNVYLKDK
Protein: Splicing factor 3b subunit 2 (E9PPJ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF
Protein: Hypocretin neuropeptide precursor (Hypocretin) (Orexin precursor) (Prepro-orexin) (Preprohypocretin) (F1P0W5)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}. Rough endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004427}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
- G_PROTEIN_RECEP_F1_2 domain-containing protein
- PMCH
- Mesotocin/neurophysin I prepropeptide
- Pro-thyrotropin-releasing hormone
- Chromosome 4 open reading frame 19.
- Appetite-regulating hormone
- Pro-neuropeptide Y
Sequence:
MEVPNAKLQRSACLLLLLLLLCSLAGGRQSLPECCRQKTCSCRIYDLLHGMGNHAAGILTLGKRKSIPPAFQSRLYRLLHGSGNHAAGILTMGKREERPGTACRDALSCAAGTQPTVTPRGTAASPRECQEHAEKDLTKGWAAAKSFY
Protein: Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (P18519)
Organism: Gallus gallus (Chicken)
Function: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (By similarity). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (By similarity). Necessary for the circadian oscillation of clock genes in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9Z0W1}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9Z0W1}. Perikaryon {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}.
Interaction partners:
- Beta-nerve growth factor
- Neurotrophin-3
- Fibroblast growth factor
- Kit ligand
- TNF receptor-associated factor
- Disintegrin and metalloproteinase domain-containing protein 17
Sequence:
MAGFVPLLLLLLPAGPTWGSKEKCLTKMYTTSGECCKACNLGEGVVQPCGVNQTVCEPCLDSVTYSDTVSATEPCKPCTQCVGLHSMSAPCVESDDAVCRCAYGYFQDELSGSCKECSICEVGFGLMFPCRDSQDTVCEECPEGTFSDEANFVDPCLPCTICEENEVMVKECTATSDAECRDLHPRWTTHTPSLAGSDSPEPITRDPFNTEGMATTLADIVTTVMGSSQPVVSRGTADNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANNRPVNQTPSPEGEKLHSDSGISVDSQSLHDQQPPNQSTQGPAPKGDGSLYASLPPSKQEEVEKLLSSSAEETWRQLAGELGYKEDLIDCFTREESPARALLADWSAKETATLDALLVALRKIQRGDIAESLYSESTATSPV
Protein: Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) (O76070)
Organism: Homo sapiens (Human)
Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11746666}. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
Interaction partners:
- Myocilin
- Thy-1 membrane glycoprotein
Sequence:
MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAEEAQSGGD
Protein: Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (ATP diphosphohydrolase) (ATP-DPH) (ATPDase) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) (NTPDase1) (CD antigen CD39) (P97687)
Organism: Rattus norvegicus (Rat)
Function: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Subcellular location: Membrane {ECO:0000250|UniProtKB:P49961}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P49961}. Membrane, caveola {ECO:0000250|UniProtKB:P49961}.
Interaction partners:
- 5'-nucleotidase
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleoside triphosphate diphosphohydrolase 6
- Ectonucleoside triphosphate diphosphohydrolase 2
- Ectonucleoside triphosphate diphosphohydrolase 5
- AMP deaminase 2
- UMP-CMP kinase
- AMP deaminase 1
Sequence:
MEDIKDSKVKRFCSKNILIILGFSSVLAVIALIAVGLTHNKPLPENVKYGIVLDAGSSHTNLYIYKWPAEKENDTGVVQLLEECQVKGPGISKYAQKTDEIAAYLAECMKMSTERIPASKQHQTPVYLGATAGMRLLRMESKQSADEVLAAVSRSLKSYPFDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLNFISDSQKQATFGALDLGGSSTQVTFVPLNQTLEAPETSLQFRLYGTDYTVYTHSFLCYGKDQALWQKLAQDIQVSSGGILKDPCFYPGYKKVVNVSELYGTPCTKRFEKKLPFNQFQVQGTGDYEQCHQSILKFFNNSHCPYSQCAFNGVFLPPLQGSFGAFSAFYFVMDFFKKMANDSVSSQEKMTEITKNFCSKPWEEVKASYPTVKEKYLSEYCFSGTYILSLLLQGYNFTGTSWDQIHFMGKIKDSNAGWTLGYMLNLTNMIPAEQPLSPPLPHSTYISLMVLFSLVLVAMVITGLFIFSKPSYFWKEAV
Protein: GDP-6-deoxy-D-mannose reductase (EC 1.1.1.281) (Q9HTB6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Reductase that catalyzes the conversion of GDP-6-deoxy-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (GDP-D-rhamnose).
Interaction partners:
- GDP-mannose 4,6-dehydratase
- Glycosyltransferase WbpY
- Alginate biosynthesis protein AlgA
- D-rhamnosyltransferase WbpZ
- Glycosyltransferase WbpX
- ABC subunit of A-band LPS efflux transporter
- Transport permease protein
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Glycosyltransferase
- Methyltransferase type 11 domain-containing protein
Sequence:
MTQRLFVTGLSGFVGKHLQAYLAAAHTPWALLPVPHRYDLLEPDSLGDLWPELPDAVIHLAGQTYVPEAFRDPARTLQINLLGTLNLLQALKARGFSGTFLYISSGDVYGQVAEAALPIHEELIPHPRNPYAVSKLAAESLCLQWGITEGWRVLVARPFNHIGPGQKDSFVIASAARQIARMKQGLQANRLEVGDIDVSRDFLDVQDVLSAYLRLLSHGEAGAVYNVCSGQEQKIRELIELLADIAQVELEIVQDPARMRRAEQRRVRGSHARLHDTTGWKPEITIKQSLRAILSDWESRVREE
Protein: Protein channel (Q59LZ5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004572}.
Interaction partners:
- Mitochondrial import receptor subunit TOM20
- Tom22p
- Translocase of outer membrane 40 kDa subunit
- Mitochondrial outer membrane protein porin
- Tom7p
- Mitochondrial import inner membrane translocase subunit TIM17
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM23
- Mitochondrial import inner membrane translocase subunit TIM21
- Mitochondrial import inner membrane translocase subunit TIM8
Sequence:
MSSDNFFIKNRTAIIVTALTAFSAAGAYYYYTQQQSTGGSNSSSKSNKSSSEEGNTSTSSSSSKKKKKSKKSKGSATPEPTNSTSSSTTTTTTTTTTSSSDSKSTSSKKIKYPINSEGLPELTSDIISKLSETEKEEWAMQLKEDGNQEFKNKNFKKAIEFYSAALELKQDPIYYSNRSACYAALDDHENVIKDTTEAINLKPDYTKCILRRATSFEVLEKYEDAMFDLTALTIYGGFSNKSIEQVLERVLRKHSIKIVESKPKKLILPSAATIGSFFGAFVEETEPEGINESHENEGVKALYTALQKINANTQNGYEEADELISKAVTELESAIESATELKPVLAIALEYLAAFQFLKNDPVSAAESIEKAISLKPRPRAYVFRALINADKSSYEAALKDFKTAEELDDKCPDIFYHLGQLFYLTGDLTNAEINFNKAKELHPDNVYAYIQLACITYKNGQIELANEKFTEAKLKFPTSPEVPNYYGEILADKGDIQGACKQFEIASRLQEKLDRFSVGALPLINEATVISRESLEKIGEAEELLTKACALDPKSELARISLAQIKLQKDEVDDAIVLFEESSDLARSIEEKIQATSFAEATKMQKRIKNDPILNNKIAELMRQSGAM
Protein: Nanos homolog 2 (NOS-2) (P60321)
Organism: Homo sapiens (Human)
Function: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19168545}. Cytoplasm, P-body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168545}. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. {ECO:0000250}.
Interaction partners:
- CCR4-NOT transcription complex subunit 1
- Stimulated by retinoic acid gene 8 protein homolog
- Cytochrome P450 26B1
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 11
- CCR4-NOT transcription complex subunit 6-like
- CCR4-NOT transcription complex subunit 6
- Zinc finger and BTB domain-containing protein 16
- CCR4-NOT transcription complex subunit 2
Sequence:
MQLPPFDMWKDYFNLSQVVWALIASRGQRLETQEIEEPSPGPPLGQDQGLGAPGANGGLGTLCNFCKHNGESRHVYSSHQLKTPDGVVVCPILRHYVCPVCGATGDQAHTLKYCPLNGGQQSLYRRSGRNSAGRRVKR