wanglab/gogpt-training-data huggingface dataset:
Protein: Lipoyl synthase, apicoplast (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase) (Q8IDQ0)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Subcellular location: Plastid, apicoplast {ECO:0000255|HAMAP-Rule:MF_03123}.
Interaction partners:
- Lipoate--protein ligase 1
- Inactive lipoate--protein ligase 2
- Glycine cleavage system H protein
- Lipoate-protein ligase B
- Hydrolase, putative
Sequence:
MHFGIPSLFYLYILFSIIMRIKCVITKNLKKTKKRTCSYIPHGNMEKGIILNYIEKPNPAYLKRGKNKNKNKNKKGDIYKLRNVEILLYANRYVHEGNENFSSTTKKLLLTPKVGNKMPEGKKPDWFHVAAPTVAKYNKLKDDIKKLNLHTVCEEAQCPNIGECWNIGTATIMLLGDTCTRGCKFCSIKTSSNPLPPDINEPFNTAKAICEWNIDYVVLTSVDRDDLPDGGASHFAKTVELVKFSRPDILIECLVSDFQGNIDSVRKLAFSGLDVYAHNIETVKRLQKYVRDKRANYDQSLFVLKTAKEINPQLYTKTSIMLGLGETKEEVIQTMYDARKNNIDVITFGQYLRPTKNHLSIVQYISPQMFEYYKEEGLKMGFKYIASGPLVRSSYKAGEYFIKNLVNQRNKDKKN
Protein: Uncharacterized protein, isoform A (A0A0B4K6A8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD32974p
- LD17744p1
- LP04037p
Sequence:
MAHWTLVVLLVVSALMGLSQAYSLCSMDGRAHCVMPENCKVPITLGQRENTGCGESLVCCDVESLDLPCGPNKSHQCVPDDCLLPFHYKFSTECPTCFICTAPNINKIPLSIKEKL
Protein: DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) (P06746)
Organism: Homo sapiens (Human)
Function: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
Subcellular location: Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
Interaction partners:
- DNA repair protein XRCC1
- DNA ligase 3
- DNA repair nuclease/redox regulator APEX1
- Poly [ADP-ribose] polymerase 1
- DNA ligase 1
- Bifunctional polynucleotide phosphatase/kinase
- Poly [ADP-ribose] polymerase 2
- Flap endonuclease 1
- Tyrosyl-DNA phosphodiesterase 1
- Endonuclease 8-like 1 lyase Neil1)
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
Protein: Proline-rich protein 3 (AtPRP3) (Q9LZJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May contribute to cell wall structure in root hairs.
Subcellular location: Secreted, cell wall {ECO:0000305}.
Interaction partners:
- Proline-rich extensin-like family protein
- Expansin-A18
- Proline-rich extensin-like family protein
- Proline-rich extensin-like family protein
- Leucine-rich repeat extensin-like protein 1
- Expansin-A7
- Xyloglucan endotransglucosylase/hydrolase protein 14
- Peroxidase 73
- Peroxidase 7
- Putative pectinesterase/pectinesterase inhibitor 24
Sequence:
MAITRSSLAICLILSLVTITTADYYSPSSPPVYKSPEHKPTLPSPVYTPPVYKPTLSPPVYTKPTIPPPVYTPPVYKHTPSPPVYTKPTIPPPVYTPPVYKPTLSPPVYTKPTIPPPVYTPPVYKPTPVYTKPTIPPPVYTPPVYKPTPSPPVYKKSPSYSSPPPPYVPKPTYTPTTKPYVPEILKAVDGIILCKNGYETYPILGAKIQIVCSDPASYGKSNTEVVIYSNPTDSKGYFHLSLTSIKDLAYCRVKLYLSPVETCKNPTNVNKGLTGVPLALYGYRFYPDKNLELFSVGPFYYTGPKAAPATPKY
Protein: Cytochrome P450 2H1 (EC 1.14.14.1) (CYPIIH1) (Cytochrome P450 PB15) (Cytochrome P450 PCHP3) (P05180)
Organism: Gallus gallus (Chicken)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- Uncharacterized protein.
Sequence:
MDFLGLPTILLLVCISCLLIAAWRSTSQRGKEPPGPTPIPIIGNVFQLNPWDLMGSFKELSKKYGPIFTIHLGPKKIVVLYGYDIVKEALIDNGEAFSGRGILPLIEKLFKGTGIVTSNGETWRQLRRFALTTLRDFGMGKKGIEERIQEEAHFLVERIRKTHEEPFNPGKFLIHAVANIICSIVFGDRFDYEDKKFLDLIEMLEENNKYQNRIQTLLYNFFPTILDSLPGPHKTLIKNTETVDDFIKEIVIAHQESFDASCPRDFIDAFINKMEQEKENSYFTVESLTRTTLDLFLAGTGTTSTTLRYGLLILLKHPEIEEKMHKEIDRVVGRDRSPCMADRSQLPYTDAVIHEIQRFIDFLPLNVPHAVIKDTKLRDYFIPKDTMIFPLLSPILQDCKEFPNPEKFDPGHFLNANGTFRRSDYFMPFSAGKRICAGEGLARMEIFLFLTSILQNFSLKPVKDRKDIDISPIITSLANMPRPYEVSFIPR
Protein: Class I diterpene synthase TPS6, chloroplastic (Labd-13(16),14-diene-9-ol synthase) (EC 4.2.3.-) (Syn-isopimara-7,15-diene synthase) (EC 4.2.3.-) (Terpene synthase 6) (VacTPS6) (A0A2K9RFZ9)
Organism: Vitex agnus-castus (Chaste tree)
Function: Involved in the biosynthesis of labdane-type diterpenoid including cleroda-dienols, and peregrinol lactones and furan derivatives, dopaminergic diterpenoids that can bind to dopamine receptors in the human pituitary gland, have probably ability to lower prolactin levels, and are used to treat menstrual cycle disorders (e.g. premenstrual syndrome and mastodynia) (Probable). Terpene synthase the catalyzes the conversion of peregrinol diphosphate to labda-13(16),14-dien-9-ol, and of syn-copalyl diphosophate to dehydroabietadiene and syn-isopimara-7,15-diene.
Subcellular location: Plastid, chloroplast {ECO:0000305|PubMed:29315936}.
Interaction partners:
Sequence:
MSLRFNLIVTPFSNYEIRNRRETFPVQKFLMTTSKSAIKVKCSLKTSIDLVGKIREKINGKVDNSLEVPTINYLVDIPSNLCMIDSLERLGVARYFQSEIDGVLEKTYRLWQQREKDIFADVTCRAMAFRFLRVKGYEVSSDELAPYADQVHVNPQISDVTTVVELYRASQVRIYEEDSILEKLHAWTSTFLKQQLQSKTISDKKLHEQVEYYLKNYHGIQNQVAVRRSLDLYDIDHYPILKVADRFRIIYNEDFFVFLRQDFNLCQAQHQKELQQLQRWYEDCRLDTLNYGRNVVHVSCFLAAANFGDPELSNARLAFAKTIVLVTRIDDFFDLAGSREESYKILELVKEWKEKPTEDYGSKEVEILFTALYDTVNEFAEIAYIEQGRCVKPLLIKLWVELLTSFKKELDSWTDDTALTLDEYLSSAWMSIACRVCTLTALQFLGVKLSEEMLSSQECTDLCRHLSFVNRLLNDVQTFERERKENTINAVSVLLAAHRHERAITEEEAISKIQEIVEQNRRKLMRMVYQRESVFPRKCRNVFLEVSKMGHYLYASGDELTTPQQLMEDMKSLVFEPLALHPLETNNVIASGKN
Protein: Kinesin-like protein vab-8 (Variable abnormal morphology protein 8) (Q21441)
Organism: Caenorhabditis elegans
Function: Required for posterior migration of cells and axon growth cones during nervous system assembly.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9581759}.
Interaction partners:
- Serine/threonine-protein kinase unc-51
- CRAL-TRIO domain-containing protein
- Protein sax-3
- RUN domain-containing protein
- Kinesin-associated protein
- Netrin receptor unc-40
- UNC-76
- Netrin receptor unc-5
Sequence:
MEACSSKTSLLLHSPLRTIPKLRLCASISSEDVAHGRCSLTDQHLQIEGKNYSKTTFDHIFRTDATQDDMYTAFLSDTINSVFAGNDATVLAMGAKTNGKDERLYGNSVSRNGLVQMAITQLMNALDDNKDSEERIQVRMSAIMVSQNESSIVDLLSPFNPDPRHRVVKIVDDARTGVFIDNESEIRVETIDQALFYLNTAVDHRMIQDEHTHRTSHVFISLSLYSYKMGDKMQGGRRRLCFLDMGIGERNSTNGGMTMPALGSILLAMVQRNKHIPSRDSSVCQLIRCALSTSRFTTFVFSFGAKSDDNENIAHLACKIARTRAKSMVGHGRKSSGTMSTGTMESNSSSCGTTTITPGGTPRTQRRFELESGSELSAAETVIFLGPNSSRTASPASTTMPFTPTSIRPLHRTTRNHSGVEALSKPLSVETKSSPTHNCHDGCIHSIPPMLRGHTPFLSASLKLYDELCSPPSSSRASPAPPAAFGGKTSEKREDFGIMIAQPSIPLMKAKSKYNLDDGKMKQIMQWMETSEAPPILFSSPCYENSATSVEELRECVGILSHPLEDIIEQEEESMRTSTATTGGSKKDHPLRILSKQDLNVEPEIKDKQEENELELVMAASLSSMRSHDILAKLEAMRNAQNGNSVQNIGNSQSNTDMDVSEMDVYRRASHLEEYAMQRVREIEENKLKNKKKIKLGLNCCQQQSMISSGSTVVDWSQIERKKEKEREVHEEEMRKEMLRERRAKLKITELEIKRERNLIDKELDDKKGIANSIARQLQHFSLSPCRGGRTHRSVSTHRIDPPNASLPSTPTMSHKKVIGGSLAKLSASGASGSTGAPPSPALGYHQSLPRHSKLPTSVNGRRASAERERKSNKASRNSCSKERKISGSKEELQWRSPYAQMTSPKSYGGPGTSSSGRGSSAPGSDFETPVVSTTEKSANGTIPRSKRQSYSASSGYESANDYHIYSTTNKKPHILDKKRNEEKLSLVRQADEIRHRQWQLKKELEEAKRAIGQEDDAKMIANSSDQRLNGLSRTTMIDAMLQENRILEKRLVACRNHSMLVTTFI
Protein: Autophagy-related protein (F4IHC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MAISSFKHEHPLVEMNIDVEVTKFHLSLLCSVVESLLFTGRRIAISVPWNPKILSLKKRQAEAARIREKYPDRIPVIVERAEKSDVPDIDRKKYLVPADLTVGQFVYVVRKRIKLSPEKAIFIFVKNILPPTAAIMSAIYEEHKDEDGFLYMSYSGENTFGIFF
Protein: GTPase LSG1-1 (AtLSG1-1) (DAR GTPase 6) (Protein YEAST LSG1 ORTHOLOG 1) (Q9SHS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTPase that might be redundant with LSG1-2 for ribosome biogenesis (Probable). Binds to 23S rRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25319368}.
Interaction partners:
- 60S ribosomal export protein NMD3
- Pescadillo homolog
- Probable rRNA-processing protein EBP2 homolog
- Eukaryotic translation initiation factor 6-2
- Ribosome biogenesis protein BOP1 homolog
- Large ribosomal subunit protein uL18y
- Ribosome biogenesis protein BRX1 homolog 2
- Large ribosomal subunit protein uL4z
- Chlorophyll synthase, chloroplastic
- ERBB-3 BINDING PROTEIN 1
Sequence:
MGKNEKTSLGRALVKHHNHMIQETKEKGKSYKDQHKKVLESVTEVSDIDAIIEQAEEAERLFAIHHDSATPVPINMDTGSSSSGITAKEWKEQRMREEALHASSLQVPRRPHWTPKMNVEKLDANEKQAFLTWRRKLASLEENEKLVLTPFEKNLDIWRQLWRVLERSDLIVMVVDARDPLFYRCPDLEAYAQEIDEHKKTMLLVNKADLLPSYVREKWAEYFSRNNILFVFWSAKAATATLEGKPLKEQWRAPDTTQKTDNPAVKVYGRDDLLDRLKLEALEIVKMRKSRGVSATSTESHCEQVVVGFVGYPNVGKSSTINALVGQKRTGVTSTPGKTKHFQTLIISEDLMLCDCPGLVFPSFSSSRYEMVASGVLPIDRMTEHLEAIKVVAELVPRHAIEDVYNISLPKPKSYEPQSRPPLASELLRTYCLSRGYVASSGLPDETRAARQILKDYIEGKLPHFAMPPEITRDDENETADDTLGAETREGSQTEKKGEEAPSLGLDQVLDDLSSFDLANGLVSSKTKQHKKSHRKQ
Protein: ATPase subunit 9, putative (EC 3.6.3.14) (Q385P0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- ATP synthase alpha chain
- ATP synthase subunit beta
- ATP synthase F1 subunit gamma protein, putative
- ATP synthase, epsilon chain, putative
- V-type proton ATPase subunit a
- V-type proton ATPase subunit
- H
- ATP synthase, putative
- Vacuolar proton pump subunit B
- Vacuolar ATP synthase subunit D, putative
Sequence:
MMRRLALQSSLRRVTPAAVSVMTPAKVTSPIGHAIAIRQASTVAISVQGLHYVGTGLAAIALAGVGLGIGTIFGNLLVACARQPNLTKMLFNYAILGFALTEAIGLFALMLAFLMLFS
Protein: Aspartate 1-decarboxylase (EC 4.1.1.11) (Q5E6F9)
Organism: Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Function: Catalyzes the pyridoxal-dependent decarboxylation of aspartate to produce beta-alanine. Has weak activity with glutamate.
Interaction partners:
- Pantothenate synthetase
- Glutamate decarboxylase
- L-asparaginase 1
- asparaginase
- Aspartate aminotransferase
- Argininosuccinate synthase
- Aspartate racemase
- Predicted racemase
- asparagine synthase
- Aspartate ammonia-lyase
Sequence:
MVTDNKTADASFESLLRIFTVPEAPDSTLGIIEKELSQNLNQFLREHIVAEEKPLTEIEKDFTDSSMPESPTYVSEHTEHLLDTLVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMLHRLIFGQKDSFYQHWMHSADHSLGAFCSGGTIANITALWVARNRLLKPEGDFEGIAKQGLFAALMHYKCNGLAIFVSERGHYSLKKAADVLGIGQDGVIAVKTDNNNRVCLDDLELKIAQAKAKNIKPLAIVGVAGTTETGSIDPLRELANVAQREGCHFHVDAAWGGATLMSNTYRHLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSIQHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISRPGYELLINQSIEKAHYFADLIQQQDDFELITEPELCLLTYRYVPSNVKAALAIATDEQKIEIYEHLDNLTKYIQKTQRETGKSFVSRTRLTPEAYQHQPTIVFRVVLANPLTTKEILQNVLIEQREIASSSEISLPLLNQIVGNILH
Protein: Bursicon (Q21013)
Organism: Caenorhabditis elegans
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Glycoprotein hormone subunit beta domain-containing protein
- Glycoprotein Hormone
- Serine/threonine-protein kinase flr-4
- Serpentine receptor class r-10
- THR-like peptide hormone
Sequence:
MGSKARARRRLSCFLSVFVVTCLLQYCTAGVTKNNSCKKVGVEELIDEEGCDLMIIRINRCSGHCFSFTFPNPLTKKYSVHAKCCRMVEWEMLETELKCSKGNRNLRIPSATQCECFDCLVR
Protein: Nuclear pore complex protein Nup58 (Nucleoporin Nup58) (Q9VDV3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Together with Nup54, required for transposable element silencing regulation in ovarian follicle cells. By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs(1)Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:15086791}. Note=Present also in annulate lamellae pore complexes (ALPCs). {ECO:0000269|PubMed:15086791}.
Interaction partners:
- Probable nucleoporin Nup54
- Nuclear pore glycoprotein p62
- Nuclear pore complex protein Nup107
- Nuclear pore complex protein Nup75
- Nuclear pore complex protein Nup133
- Nuclear pore complex protein Nup214
- Nuclear pore complex protein Nup93-1
- Nuclear pore protein
- Nuclear pore complex protein Nup154
- Nuclear pore complex protein Nup205
Sequence:
MFTPTTNNAIGGATAATGAFAFGARPATTTAPPPSFGAATSTPTFGAAPATTSLFAAPAATPAFGAPAATPAFGAPASTPGFGATSTAAPAFGTAAATPAFGIPAATSAFGAPAATPAFGAAAATPAFGAPAATPAFGAPAATSAFGAPAATTAFGAPASTQASAFGAPAPAVGTVAPTFSFATPATSAPTTAPPAFGFGTTATTAAAAMPASLSSGIGSFSFPKPQATTAASLNFNTTTTTATAQPFNTGLKLGTTNATTTLGGGGIFSKPAGQAAAPAASTFVGLGGIDVTATQPKLGDNKQDGIKIKETQVPDEIIKTVDGLKAYIKQQKTISSDIGRTSTSKFTNVSHEITNLKWALQNMATLVEGSNQQIRLMRQETVKAIQSLEMAQRTQDTPAGLQFENNAPFQYFQCLVAKYEQDLIAFRQQIALTERHMHAISNPQSISPDDLKRGFRQLNESFISLAGRLHEVHQRVEEHKEHYLNLRRYRLRDTTNVFERIDNPPLPTVEPQRISSGPTPFSNISALMNKSYAAAASSASNATGN
Protein: Inner membrane protein YhiM (P37630)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Protein HdeD
- Putative magnesium transporter YhiD
- HTH-type transcriptional regulator DctR
Sequence:
MNIYIGWLFKLIPLIMGLICIALGGFVLESSGQSEYFVAGHVLISLAAICLALFTTAFIIISQLTRGVNTFYNTLFPIIGYAGSIITMIWGWALLAGNDVMADEFVAGHVIFGVGMIAACVSTVAASSGHFLLIPKNAAGSKSDGTPVQAYSSLIGNCLIAVPVLLTLLGFIWSITLLRSADITPHYVAGHVLLGLTAICACLIGLVATIVHQTRNTFSTKEHWLWCYWVIFLGSITVLQGIYVLVSSDASARLAPGIILICLGMICYSIFSKVWLLALVWRRTCSLANRIPMIPVFTCLFCLFLASFLAEMAQTDMGYFIPSRVLVGLGAVCFTLFSIVSILEAGSAKK
Protein: Large ribosomal subunit protein mL52 (39S ribosomal protein L52, mitochondrial) (L52mt) (MRP-L52) (Q9D0Y8)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q86TS9}.
Interaction partners:
- Large ribosomal subunit protein mL55
- Large ribosomal subunit protein mL65
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein uL30m
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein uL4m
- Small ribosomal subunit protein bS18m
- Large ribosomal subunit protein mL66
- Small ribosomal subunit protein bS16m
- 39S ribosomal protein L40
Sequence:
MAALGTWLSSVRRLHCSVVARAGGQWRLQQGLAANPSGYGPLTELPDWSFADGRPAPPMKGQLRRKAQREKLARRVVLLTQEMDAGIQAWKLRQQKLQEERKKEHDLKPKGTLLRSPLPNQ
Protein: Ephrin-B2 (ELF-2) (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) (P52800)
Organism: Mus musculus (Mouse)
Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P52799}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000269|PubMed:30639848}.
Interaction partners:
- Ephrin type-B receptor 4
- Ephrin type-A receptor 4
- Ephrin type-B receptor 1
- Ephrin type-B receptor 2
- Ephrin type-B receptor 3
- Ephrin type-B receptor 6
- Ephrin type-A receptor 1
- Regulator of G-protein signaling 3
- Cytoplasmic protein NCK2
- Ephrin-B1
Sequence:
MAMARSRRDSVWKYCWGLLMVLCRTAISRSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCARPDQDVKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSARNHGPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNLLGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRGGNNNGSEPSDVIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
Protein: MGT2 magnesium transporter (Q57XY6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPCATKGEASPPVTTPVGRDGCLCVVTWQTAGRMSLQTCALESAADALVFLRNNLPGIALCGLWVDMQKCSEEEHRQVLQLLYPNMQPSHVEAVLANDMYDVVELQPTEGEYVVGCLSCSPSHGGPFPAATAMSRTELGCEEGVLCSFVCSERVLLTLHTAPFAGLAELFRHVLKCNGSEAERHSRECEDSVVGIVKDPSSHRSSFVPVAMGTDALCTLVCFTCEASFPAPASLLSEVGDINEMVFLISPGEQDQTDLLRRVALLRRRISSFRTALFLKEKLIHQLISPAMRLTFVSKSHPSAVAYKEILARVQKVSEKLDDARDMLNHANLNFITGVSMRMSQASAGLDFKMNILNSVAAVSLPINLVVSLFGMNLKVPFMTGEGSTLIPFWTICAVFVVWAGICLTPLFRRAQRGLKNDPIAPYE
Protein: Tegument protein BLRF2 (Q3KST5)
Organism: Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)
Function: Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA. Acts by inhibiting CGAS-DNA phase separation: directly binds double-stranded DNA (dsDNA) in a length dependent but sequence independent manner and is able to form DNA-induced phase separation in infected cells. DNA phase separation of ORF52 mediates disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity.
Subcellular location: Virion tegument {ECO:0000250|UniProtKB:P03197}. Host cytoplasm {ECO:0000250|UniProtKB:P0C717}.
Interaction partners:
Sequence:
MSAPRKVRLPSVKAVDMSMEDMAARLARLESENKALKQQVLRGGACASSTSVPSAPVPPPEPLTARQREVMITQATGRLASQAMKKIEDKVRKSVDGVTTRNEMENILQNLTLRIQVSMLGAKGQPSPGEGTRLRESNDPNATRRARSRSRGREAKKVQISD
Protein: Methylthioribose kinase (AtMTK) (MTR kinase) (EC 2.7.1.100) (Q9C6D2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate in the methionine cycle. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis.
Interaction partners:
- Methylthioribose-1-phosphate isomerase
- Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1
- 5'-methylthioadenosine nucleosidase
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- Aromatic aminotransferase ISS1
- Homocysteine S-methyltransferase 2
- Acireductone dioxygenase 2-requiring) 2)
- GDSL esterase/lipase At4g18970
- Nicotianamine synthase 1
- Thylakoid lumenal 15.0 kDa protein 2
Sequence:
MSFEEFTPLNEKSLVDYIKSTPALSSKIGADKSDDDLVIKEVGDGNLNFVFIVVGSSGSLVIKQALPYIRCIGESWPMTKERAYFEATTLRKHGNLSPDHVPEVYHFDRTMALIGMRYLEPPHIILRKGLIAGIEYPFLADHMSDYMAKTLFFTSLLYHDTTEHRRAVTEFCGNVELCRLTEQVVFSDPYRVSTFNRWTSPYLDDDAKAVREDSALKLEIAELKSMFCERAQALIHGDLHTGSVMVTQDSTQVIDPEFSFYGPMGFDIGAYLGNLILAFFAQDGHATQENDRKEYKQWILRTIEQTWNLFNKRFIALWDQNKDGPGEAYLADIYNNTEVLKFVQENYMRNLLHDSLGFGAAKMIRRIVGVAHVEDFESIEEDKRRAICERSALEFAKMLLKERRKFKSIGEVVSAIQQQS
Protein: RPGRIP1 like (E1BJB4)
Organism: Bos taurus (Bovine)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
- Nephrocystin 4
- Nephrocystin-1
- Transmembrane protein 67
- X-linked retinitis pigmentosa GTPase regulator
- Transmembrane protein 216
- Centrosomal protein of 290 kDa
- Coiled-coil and C2 domain containing 2A
- Abelson helper integration site 1
- 26S proteasome non-ATPase regulatory subunit 2
- Intraflagellar transport protein 88 homolog
Sequence:
MSGPTDETAGDLPVKDIGLNLFGMGGLQETSTTRTMKSRQAVSRISREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYEQVGGGPKRLGRDVEMEEMIERLQEKVHELERQNEVLKSRLISTKQQLQIQGHRHTPYSYVQSRVNTGRRRVNENAGLQECPRKGIKFQDTDVAETVQTMPTKYSNSLLKEARGEIRNLENVIESQRGQIEELERLAEILKTQLRRKENEIELSLLQLREHQATDQRSNIRDNVELIKLHKQLVEKSNALSVMEGKFIQLQEKQKTLRISHDALMANGDELNLQLKEQRLKCCSLEKQLRSMTFSERRIEELQDRISDLEKERELLKENYDKLYNSAFSAAHEEQWKLKEQQLKIQIAQLETALKSDLTDKTEILDRLKTERDQNEKISQENRQLQLQYLEQKQQLDELKNRMKFYNQESDINADELSEALLLIKAQKSQKNGDLSFLEKVDSKINKDLERSMKELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTQKMENLQQDYELKVEQYVHLLDIRAARIQKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPIVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTVTLEVHQAYSTDYETIAACQLRFHEILEKSGRIFCTASLVGTKGDISNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEQMQWLSHQAPKTAQLSSTDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMCFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVSVPLISLAHDRCISGIFELTDHEKHPAGTIHVILKWKFAYLPPSGCITTEDLGNFRHKEESEVVQRLLPTSSFSTIIAAPTPKPRRLTTKDKKVSFMDITPHQHYETSTLPEDRKEISPEVEHIPEREIDMPTVSHIPKVPQESSVDKVKENTEKTQQGKDDDVSLLSEGQLAERSLTSSEDETEITEELEPEDEGDRSASDSDECIIPGPVSKNIKQPPEKIRIEIIALSLNDSRVTADDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVYYNYSYVIYMDKENNQAKRDILKAILLKQEMPNRSVRFTVVSDPPEDEQDLECEDIGIANVDLADVFREGRDIIEQNIDGTGGSIAQSVPPAIAEIQSLY
Protein: SIT4 phosphatase-associated family protein (F4I6B2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Phytochrome-associated serine/threonine-protein phosphatase 1
- Phytochrome-associated serine/threonine-protein phosphatase 3
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- F6D8.10
- Tapetal oleosin GRP-17
- Receptor-like protein 51
- Serine/threonine-protein phosphatase BSL1
- Serine/threonine-protein phosphatase BSU1
- Serine/threonine-protein phosphatase BSL2
- Protein RER1A
Sequence:
MFWRMAGLSTASAVEAILDKDSFTLEDLLDEDEIIQECKALNGRLLNFLREKVQVEQLIRYIIEEPLEDVEKKRTFKFPFIACEIFTCEIEMILKTLVEDEELMLLLFSFLEAKETHNSLLAGYFSKVVICLLVRKTIPFMQFIKDHQEILKQLVDLIGITSIMEVLKRLVGTDEHLYSNYTSAMQWIEDTDVLEMIVDKFGSSESPEVHANAAEILCTVARYAPPGLATKLSSPSCTGRLLKHTLEDSRPKSVLVNSLSVCISLLDPKRFTLGTYHIYGRQLTHGSMVTNPETVEGMLGSLGDLLMLLNVSSAEGVLLTTYGKLQPPLGKHRLKIVEFISVLLTVGSEAAEKEVIRLGAVKRVLDLFFEYPYNNFLHHHVENVILSCMESKNSQLVDHLLSECNLIGSILEAEKDSTLTAGDSDKLQPTVPAEGKKPLRIGNIGHLTRISNKLLQLANSNVEIQSHLQENSKWVDWQTDVLSKRNTLENVYSWACGRPTSLHDRSRDSDDDDYHDRDYDVAALANNLSQAFRYGIYSNDDMDEAQGSMERDDEDVYFDDESAEVVISSLRLGDDQESDSLFTNSNWFAFDDDKAANERSMTSAASPSPNADGDGEDDDDVVIGEADEFNATAASSPPVDMETEDSTSKHPSENPSEPEPEKSPAWVEWRETSESTAPPSSNPEETTILSNGDVQIEKEDNDDDDDTDNKSAVKTPGVPGDETTEKLPDESGVEPTENSPKASGIEPTESSPKASGAEVTGNLRDSDPAESHADAKSSEPESPHGTKETEVAAEADTKETEEAVKEPEKVV