wanglab/gogpt-training-data huggingface dataset:
Protein: Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (mMAdCAM-1) (Q61826)
Organism: Mus musculus (Mouse)
Function: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- L-selectin
- Atypical chemokine receptor 2
- Integrin alpha-4
- C-C chemokine receptor type 9
- Integrin beta-7
- Protein N-terminal asparagine amidohydrolase
- Glycosylation-dependent cell adhesion molecule 1
- C-C motif chemokine 25
- Intercellular adhesion molecule 1
- T-cell surface glycoprotein CD4
Sequence:
MESILALLLALALVPYQLSRGQSFQVNPPESEVAVAMGTSLQITCSMSCDEGVARVHWRGLDTSLGSVQTLPGSSILSVRGMLSDTGTPVCVGSCGSRSFQHSVKILVYAFPDQLVVSPEFLVPGQDQVVSCTAHNIWPADPNSLSFALLLGEQRLEGAQALEPEQEEEIQEAEGTPLFRMTQRWRLPSLGTPAPPALHCQVTMQLPKLVLTHRKEIPVLQSQTSPKPPNTTSAEPYILTSSSTAEAVSTGLNITTLPSAPPYPKLSPRTLSSEGPCRPKIHQDLEAGWELLCEASCGPGVTVRWTLAPGDLATYHKREAGAQAWLSVLPPGPMVEGWFQCRQDPGGEVTNLYVPGQVTPNSSSTVVLWIGSLVLGLLALVFLAYRLWKCYRPGPRPDTSSCTHL
Protein: E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) (Q06587)
Organism: Homo sapiens (Human)
Function: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:21282530}.
Interaction partners:
- YY1-associated factor 2
- Polycomb complex protein BMI-1
- Polycomb group RING finger protein 6
- Polycomb group RING finger protein 3
- E3 SUMO-protein ligase CBX4
- Polyhomeotic-like protein 1
- Chromobox protein homolog 8
- E3 ubiquitin-protein ligase RING2
- Polycomb group RING finger protein 2
- RING1 and YY1-binding protein
Sequence:
MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGEGDGEDVSSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
Protein: ATP-dependent DNA helicase 2 subunit KU80 (EC 3.6.4.12) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (Q75IP6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU70, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Os01g0685500 protein
- ATP-dependent DNA helicase 2 subunit KU70
- Putative DNA ligase 4
- Double strand break repair protein, putative, expressed
- DNA ligase
- Chlorophyll a-b binding protein
- Double-strand break repair protein MRE11
- Double-strand break repair protein MRE11
- Telomerase reverse transcriptase
- ATP-dependent DNA helicase
Sequence:
MARNKEALVLLLDVGPSMHGVLQEVENICSTLVHKKLVYNRSDEIGVVLFGTKETSNELAKELGGYKHVVVARDIKVVDEETTNALQNLPRGTSPGDFLDAIVVGLDMLIRKFGNIKGKQRMCLVTDAQHPLRDPPQGTKKDQVDTIADQMKRHEIKMDCIIFRESGVRHNAVMDENDQLLYHFRERSVTKVVHVDSPTSLLGALRTRNVLPVTVFRGDLEVSSSFKIKVWVYKKTSEEKFPTLKKYSDKAPASDKFASHEVKVDYEYKSVLEPDTVVPPDQRIKGYLYGPQVVPISSAEWEAVKFKPEKGVKLLGFTDRSSISRHYFMKDVFSFVPEPGNTKAVAAVSALARAMSEMNKVAILRCVWRQGQGNVALGVLTPNISSAKNVLDSFYFNILPFAEDIREFQFRSFSSLPSSSQPTKEQQEAADNLVKMLDLAPPGREEILKPDFTPNPMLERFYRYLDLKSKQPDANVPPLDKCLKKITEPDPDVIDYQAPLIKKLGNVFELKENPKKKKARTQDRLTYTGADDQAKLLEEPSAEKVGVSEALYPPKKKAGEIGDHNPVQDFEAMLTQRSSSTWVQTAIEEMQKYITALIQDSCDRDNHQKALECLVALRKACIIEQEPNEYNGFVTKLCQKFRPAGDKIFLQLLSSKKASLISKEEAPDSDVTEEMARNFCLKPEPSSQ
Protein: Uncharacterized protein (Q38AY8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNPFVFSLYVAATVSLSLLFDCAAAYCPSNGNTHAVYVTSNAADNIWAFDTEGRFIGNVLNKESFPVRVEKLRDMKFGPGEHLYIASARGKFSRIFAVSGNGVLNGTLGKNCTRDYLFTVAEQDDNNPMLDHPYAIVFNPDDDSLYASNQNSVTVARYTRVDDGKGKYPRWEPAENSVFALTNGSAASKIPKKVGLFVSPWSNEYALLSVRGLAISPPLPRFLVEQAAPAGSFATGEGLLARYLVLCDIALNKLLVFYADTGAYVFSITVPSPVQVAFPSRYFKPIESPASYFEVPHMYVTSKEDGMVYLVPLVGKSSPVAASDFNTPHQRQPSYPVTSPVFMHAASGIYENPSHDLLLIADRVGRSIMSYVSPFRSGATEGEGPSPFLGYFVRALPDMPEFVLTTAVEQQSAIPFCYELTGDGTFRYVALCTAAYIWTTVATIFFALLSLIYTTRLCKGCVRRLKSSYKNYFKHMGAREAEDVELLQHEINSGYGTNN
Protein: Intraflagellar transport 20 (D3ZSV1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
- Intraflagellar transport protein 57 homolog
- TRAF3-interacting protein 1
- Intraflagellar transport 52
- Intraflagellar transport protein 27 homolog
- Intraflagellar transport protein 80 homolog
- Intraflagellar transport 88
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 172 homolog
- Intraflagellar transport protein 22 homolog
- Thyroid hormone receptor interactor 11
Sequence:
MTYLLIDTITPSKQNFSREPGRETAMAKDILGEAGLHFDELNKLRVLDPEVTQQTTELKEECKDFVDKIGQFQKIVGGLIELVDQLAKEAENEKMKAIGARNLLKSIAKQREAQQQQLQALIAEKKMQLERYRVEYEALCKVEAEQNEFIDQFIFQK
Protein: PSP1 C-terminal domain-containing protein (Q385Z8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAANEGNQSCMDALSSITFAQLAGPLQPVYGPSRVPRHQQFVDLVTDSSGMSPFIPFGTQGSANSSTAFPVDNAYLSKRAPPESEGQNRAAYYNNSSASMQTPEKVDKPQMLRQVSVGAPTPSSGMGMTASPATVCRYITHATPGSALLDETCTRTYLRSAPMNFVASTGITTDNAIGAVSNAVLSAAAAALPSVKVSIDDKPTSLAIELEQAYEEHVHESKRRVGDKVKRKEKKVLVTVGFPGVDNVPQMISDGTEEQLLNKEEVEQGKRRRERRQSRGKNKQKGDNNNNNCIFHDGDKFVSNFSSIHADNESHGECGDRKFLVTLRCHGHRDVTAICCLRLSKGKYVIFEADRGVDLGEVINVKELISEPSGNSAPAQVLRCALDEEVEDWKGPLVERENEAVEECRHVCEQLGLTIRVVGAAYQFDRQKLTFMYESDDRVDFRALLQVMFSKFRCRIWMERRGRGHQDNDAHTG
Protein: Scarecrow-like protein 30 (AtSCL30) (GRAS family protein 17) (AtGRAS-17) (Q9SNB8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in plant development.
Subcellular location: Nucleus {ECO:0000269|PubMed:18500650}.
Interaction partners:
- EID1-like F-box protein 1
- EID1-like F-box protein 2
- Transcription factor BOA
- Protein FAR1-RELATED SEQUENCE 2
Sequence:
MDAILPVPVDGFRFDTGSGSCCKPRNNLESGTTNRFTCFNESESQSNPSPTESKVCSDYLPVFKYINDMLMEEDLEGQSCMLEDSLALQAAERSFFEVLQDQTPISGDLEDGSLGNFSSITSLHQPEVSEESTRRYRHRDDDEDDDLESGRKSKLPAISTVDELAEKFEEVLLVCQKNDQGEATEKKTRHVKGSSNRYKQQKSDQPVDMRNLLMQCAQAVASFDQRRAFEKLKEIREHSSRHGDATQRLGYHFAEALEARITGTMTTPISATSSRTSMVDILKAYKGFVQACPTLIMCYFTANRTINELASKATTLHIIDFGILYGFQWPCLIQALSKRDIGPPLLRVTGIELPQSGFRPSERVEETGRRLKRFCDKFNVPFEYSFIAKNWENITLDDLVINSGETTVVNCILRLQYTPDETVSLNSPRDTALKLFRDINPDLFVFAEINGTYNSPFFLTRFREALFHCSSLFDMYETTLSEDDNCRTLVERELIIRDAMSVIACEGSERFARPETYKQWQVRILRAGFRPAKLSKQIVKDGKEIVKERYHKDFVIDNDNHWMFQGWKGRVLYAVSCWKPAKK
Protein: Probable ERAD-associated E3 ubiquitin-protein ligase ASI1 (EC 2.3.2.27) (Amino acid sensor-independent protein 3) (P53983)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation. Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals. Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1.
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:17085444}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:17085444}.
Interaction partners:
- Protein ASI2
- ERAD-associated E3 ubiquitin-protein ligase ASI1
- E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5
- E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit CDC16
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit MND2
Sequence:
MSTNILQHVKQLLHNRDVFSFFHNKTGNLNYLDNTTQKPEVFVSPNSTIVSAPTLDSFQALMEKGNFTTLQLAKVGIRMFFSYSVSKYAVLCFSTAIILNRLTVMSSLRSNSTNIRLPLWSKTLLHLVATLSLVKALLQILSQFGLMHELHVSDTDFYALSVYLFVALSDCIEIFISSTTNVPSLICSDFSIWGLSLNLYIISKMPAGQQHIGDNVELLGAVFHRLVIHLVELFHIRAYRLCGEVILNAGFFTAFVTRTYLNGLDFINICLIHNYFPGFFYISTILLASIGIFLKALFTSNPFRSLYSRYKNLEKWWRSNNYNGEEEFNEIALSLCLLLTSNDYKIFKKSDNVKSVDEVAAFSNSYVVSGHLNQLQSTPEDLLSRKEMTTDSQLPGFARTYLGLFELVRTIILTYSRLLKNLLWSKNFESSIDKKPRVGKRKKRDLNKYVTEKNYKKFLYKPDVKELNIESDLRSLELLLPEDDSSKDYFPPRKIDESVSDEEFDSDMESQLIIDEEKELTHLSSNAVDSDDLEEIAWNISMWSILNYEMDVHNKVNGPLTRSQYGKRNPQGVLVDVVIERLLHHTNSRYMYKRLNMKDDDKLEFKFDFAFDSCDEVEEMDLSCLICKVNKRNIVTWPCRCLALCDDCRISLGYKGFATCVSCDSEVKGYSKLNIV
Protein: Putative uncharacterized membrane protein C622.03c (O94593)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MNPKKSIQLWELQSLLKGATYKKLIEKKTYEAGKERADNYDFLFMSFISFIVSCRLFILVFTFIFKGFPSAIQVIAMIDAVVNALLILIVLAMLFIGSRKLTVEIRRGEVEDFQENLKAREDTFNSSPYQRY
Protein: Pumilio/PUF RNA binding protein 8, putative (Q582W0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nucleolar protein, putative
- rRNA processing protein, putative
- Ribosome production factor 2 homolog
- Ribosome biogenesis protein, putative
- Nucleolar GTP-binding protein 1
- RNA-binding protein, putative
- RNA-binding protein, putative
- Ribosomal protein L1p/L10e family
- ATP-dependent RNA helicase
- Peter pan protein, putative
Sequence:
MGKTNTKKQEARVARLRSLPKSERLVKIARIKKREGRILDSAEKHALKMSSEYGEIIRLWEVLRTSEGQSKEEEEKEKQKKKGKNKKGEDSTDDVKQQKLSRYKHKYPTVDKLLKKIEPKFDTYVRTPRTSRVIQSMIKYGSTEQLGKIVGLISSGYANYATDAYGHFVVVALLRHAPHDLFDKILSLTIPAVPTLISHRFGIEVIHSAYSSNLCTATNRNLLILAVFKDNIALMKRWKGYPILEDVLAQEVEQRKRLLPKLFELCEKLVSQKSAVDFPFVQRLAAAFIRNGTKHEVSELCDTLRPHLAVLCTIREGAPLASLAFSLTEPKKRKVILRAFSENLGVLVVSKYSAPVIARLFDIVYDVQLLCKYVVNDVVSHITQLINSPFGHQILLHLLTPHDERKTKFLLPNWFQHNLYSVENTRWNCHTWLTHEYKEEEVELCSKDAEQTHLAVLPTLIKKFLEVLSNSEVASKLNKHYVGLIAREVLHVHEKEPAYRKALKLSANDVQVLERLSLSRGKKEPRHEEGGNSVGKITSEVQNKTKGRRLERPQMQKPAETPRVVKKMMKSSGVERSRKEGTKVETVSHAVSTLKKKKKVLPKK
Protein: Protein 4.1 (Band 4.1) (Erythrocyte membrane protein band 4.1) (A0A2U3TZH6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGVKKTSVLPSERKPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
Protein: 26S proteasome regulatory subunit RPN2 (P32565)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- 26S proteasome regulatory subunit RPN5
- Ubiquitin carboxyl-terminal hydrolase 6
- Proteasome subunit beta type-4
- 26S proteasome complex subunit SEM1
- 26S proteasome regulatory subunit RPN3
- 26S proteasome regulatory subunit RPN8
- Proteasome subunit alpha type-4
- 26S proteasome subunit RPT4
- Ubiquitin carboxyl-terminal hydrolase RPN11
- Proteasome subunit alpha type-3
Sequence:
MSLTTAAPLLALLRENQDSVKTYALESINNVVDQLWSEISNELPDIEALYDDDTFSDREMAALIASKVYYNLGEYESAVKYALAAKDRFDIDEKSQFVETIVSKSIEMYVQEASKQYTKDEQFYTKDIIDPKLTSIFERMIEKCLKASELKLALGIALEGYRLDIIESALKSKLDQDSTSENVKIINYLLTLAITTVTNSKFRSSILRKSFDFLMNMPNCDYLTLNKVVVNLNDAGLALQLFKKLKEENDEGLSAQIAFDLVSSASQQLLEILVTELTAQGYDPALLNILSGLPTCDYYNTFLLNNKNIDIGLLNKSKSSLDGKFSLFHTAVSVANGFMHAGTTDNSFIKANLPWLGKAQNWAKFTATASLGVIHKGNLLEGKKVMAPYLPGSRASSRFIKGGSLYGLGLIYAGFGRDTTDYLKNIIVENSGTSGDEDVDVLLHGASLGIGLAAMGSANIEVYEALKEVLYNDSATSGEAAALGMGLCMLGTGKPEAIHDMFTYSQETQHGNITRGLAVGLALINYGRQELADDLITKMLASDESLLRYGGAFTIALAYAGTGNNSAVKRLLHVAVSDSNDDVRRAAVIALGFVLLRDYTTVPRIVQLLSKSHNAHVRCGTAFALGIACAGKGLQSAIDVLDPLTKDPVDFVRQAAMIALSMILIQQTEKLNPQVADINKNFLSVITNKHQEGLAKFGACVAQGIMNAGGRNVTIQLENADTGTLDTKSVVGLVMFSQFWYWFPLAHFLSLSFTPTTVIGIRGSDQAIPKFQMNCYAKEDAFSYPRMYEEASGKEVEKVATAVLSTTARAKARAKKTKKEKGPNEEEKKKEHEEKEKERETNKKGIKETKENDEEFYKNKYSSKPYKVDNMTRILPQQSRYISFIKDDRFVPVRKFKGNNGVVVLRDREPKEPVALIETVRQMKDVNAPLPTPFKVDDNVDFPSA
Protein: Actinodin1 (E7F5V5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Prospero homeobox 1a
Sequence:
MAHLRGSSIFHVLLLATLILPAFLLAGPVTQRLKGDDGSDDKTGLEEAPKKLIRNRRNISWYKQHSDFWNWYKYFTDNENKDGVAELDRVYLSYLQNKNRAESRRSYKMYLQHLGDIYKSCAESDDPNCVSSYTNRPKPKAEAPVPAPVKSCDPYRDPYCLYSKGYSYYPYLAPAPVKSPAPAPAPVKAPAYLHTPVVKDPRSGQYYYSPLVQPFLSAEQRAELLRICDAEDVECLQYHLRAAYGYRSAAALAPSYAHLGCDPKTDPQCVPHLVQKAPSGLYLRYPNCDPRVDPYCAYAAALASSQNPESPPCNPLYEDNCNPLTATRIGSLAHENLKDKLNSEAGAMRAPQIPQHDPYAMFRDASAGADLRRHMPAQLQPPRYHQPEEPEHPLGPRGKTKEGYECFVGYDKECIPLSSQNERRPAVHRQPSYPAEAYEPHLNADGSRTGVIEPDPDCDPEYDRNCRLRRYEPEPAEPVSISPQEDVAHPAQEPSHHEEIPQHREESYPETPGYDQQQYDAYMSGQEDPYAGYGPQEPGAASFQDVLRGYGGRYPGQDDHLAYNGDYRKK
Protein: Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog) (Vasa-like protein) (Q6GWX0)
Organism: Sus scrofa (Pig)
Function: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q61496}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q61496}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q61496}.
Interaction partners:
- RAN binding protein 9
- Deleted in azoospermia-like protein.
- Synaptonemal complex protein 3
- Stimulated by retinoic acid 8
- PR/SET domain 14
- Zinc finger and BTB domain containing 16
- Mast/stem cell growth factor receptor Kit
Sequence:
MGDEDWEAEINPHVSSYVPIFEKDGYSGENGDKFNRTTASSSEMDDGPSGRDHFMKSGFTSGRSYGKRDAGESNKRENTSTTGGFGVGKSFGNRGFSNNRFEDGDSSGFWRESTNDCEDNTTRNRGFSKRGGSRDGNKSEASGPFRRGGRGSFRGCRGGFGLGSQNSELDPDQGMQRGGGLFGSGRPAASDTGNGDTYQSRSGRGRGGYKGLNEEVVTGSGKNSWKSEAEGGESSDTQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIVAPTRELVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQADLQVGQYSKREKLLEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQDVPAWLEEIAFSTYIPGFSGSTRGNVFASVDTRKGKSTLNTAGFSSSQAPNPVDDESWD
Protein: Glycerol-3-phosphate dehydrogenase [NAD(+)] 1 (EC 1.1.1.8) (Q00055)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15210723}. Peroxisome {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15210723}.
Interaction partners:
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Glycerol-3-phosphate O-acyltransferase 2
- Glycerol-3-phosphate O-acyltransferase 1
- Dihydroxyacetone kinase 1
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- Nicotinamidase
- Dihydroxyacetone kinase 2
- Lipid phosphate phosphatase 1
- Diacylglycerol pyrophosphate phosphatase 1
Sequence:
MSAAADRLNLTSGHLNAGRKRSSSSVSLKAAEKPFKVTVIGSGNWGTTIAKVVAENCKGYPEVFAPIVQMWVFEEEINGEKLTEIINTRHQNVKYLPGITLPDNLVANPDLIDSVKDVDIIVFNIPHQFLPRICSQLKGHVDSHVRAISCLKGFEVGAKGVQLLSSYITEELGIQCGALSGANIATEVAQEHWSETTVAYHIPKDFRGEGKDVDHKVLKALFHRPYFHVSVIEDVAGISICGALKNVVALGCGFVEGLGWGNNASAAIQRVGLGEIIRFGQMFFPESREETYYQESAGVADLITTCAGGRNVKVARLMATSGKDAWECEKELLNGQSAQGLITCKEVHEWLETCGSVEDFPLFEAVYQIVYNNYPMKNLPDMIEELDLHED
Protein: G-protein coupled receptor 6 (Sphingosine 1-phosphate receptor GPR6) (P51651)
Organism: Rattus norvegicus (Rat)
Function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor (By similarity). {ECO:0000250}.
Interaction partners:
- G protein-coupled receptor 88
- G protein-coupled receptor 55
- N-arachidonyl glycine receptor
Sequence:
MNASAAALNESQVVAVAAEGAAAAATAAGTPDTSEWGPPAASAALGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYVVPSETVSLLMVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLADRASCSVVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLFCGCFQSKVPFRSRSPSEV
Protein: BTB domain-containing protein (Voltage-gated K+ channel isoform 1) (G5EEK7)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDSEYRIILNVGGVRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPLDVCGPLFEEELKYWGLDSNECEPCCWMTLSGTRDTQDVLKTLDELDIEVDQTEGPELYKRFGWEDDYHNDSLSAWQKIKPRIWRLFDEPNSSRSAQFIAAISVFFLITAIIVFCLKTHPGLRIPELAPFGNFSRNHRSTSSRIHPAQINIDKANSRPHPTFMYIETICNIWFTIEILARFSSCPSRFEYLRAPVNIIDIVATLTFYIDLLSSMFGATADLEFFSIIRIMRLFKLTHHNSGLKILMHTFRASAKELMLLVFFLVLGVVVFASLVYYAERVESNEDNQFVSIPIGLWWAIVTMTTIGYGDITPHTYLGRLIGSICALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVLSMDQVAQHVKHAPVRNSNGPTQRKNMENTPLVSNNHTPPHTLI
Protein: Interleukin-6 (B7TXY8)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MNSLFTSAFSPLAVSLGLLLVMTSAFPTPGPLGEDFKNDTTPSRLLLTTPEKTEALIKHIVDKISAIRKEICEKNDECENSKETLAENKLKLPKMEEKDGCFQSGFNQAICLIKTTAGLLEYQIYLDFLQNEFEGNQETVMELQSSIRTLIQILKEKIAGLITTPATHTDMLEKMQSSNEWVKNAKVIIILRSLENFLQFSLRAIRMK
Protein: Odorant receptor 131-2 (Odorant receptor family H, subfamily 131, member 2) (B3DH96)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable olfactory receptor.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21124770}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:21124770}. Note=Mainly found at the plasma membrane. Also shows punctate cytoplasmic expression. {ECO:0000269|PubMed:21124770}.
Interaction partners:
Sequence:
MNSTSNSSLGNTFISKTLKEKSLTVQVLVGILLYVNGLMIFTFLKKETFRDTRYILFAQTLFVDSALMLFADLTLVGSAYELFIHIISCYIFCTVMALLSICSPVTLVAMCLERYVAICLPLRHASISSPKNTINGLLIIWGVSSVIPLFIFIVSFTYTPPNAMNSYVVCSNDVMFQVKWLAEMRALSQQLLFVIMLCIVGSTYIKIMVAAKSASAENKKSTYKGLRTVILHGLQLILGMMQLITPYIDILTLKVDIMLFINVKFSNFMLFWIFPRCLSPLVYGLRDKKFYNALKYYAFCGIYVCKKHKIKDSKTIRGAVSIAIY
Protein: Rac GTPase-activating protein 1 (Q6P3H8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Kinesin-like protein
- Epithelial cell-transforming 2
- Kinesin-like protein
- Kinesin family member 11
- Kinesin family member 20Ba
- Protein regulator of cytokinesis 1b.
- Anillin
- SHC SH2-domain-binding protein 1.
- Nucleolar and spindle-associated protein 1
- Uncharacterized protein.
Sequence:
METAVMNLHSIFESLRAQADVLNESIEPQFIQLAINFEDNRRRWLRLEQELNACKEVLTKAETERGALEVKLKHARNQVDVEIRRRQKAESDCAKLDRQIQLIRELLVSEGSSSSIQLNEEQRSALAFLNARSQNPANLNTSRRLATIDESASILSDISYDKTDDSLDWDSSAIRTVRLKKRQKRRSSRNHTEGPPAAAKRSRSTGRTSEKGNESLVAKTTVTVPADGGPIEAVTTVEAVPYWTRSRRKTVFCSSEQCISLNYSSAAVEWDTVDTDSVQSMDVFKQPSLPNAENRAEPSTPQGNGGVRLHEFISKTVIKPESCVPCGKRIKFGKISLKCRDCRVVAHPECRERCPLPCIPSMTGTPVKIGEGTLANYVSNTSPMIPSLVVHCINEIEQRGLHETGLYRVSGSDRVVKDLKEKFLRGKTVPLLSKVEDIHAITGLLKDFLRNLKEPLLTFRLNRAFMDAAELSDDDNSIALMYQNISDLPQPHRDTLAFLIIHLQRVAQSPATKMDITNLARVFGPTIVGHAVSNPEPMTILQDTKRQPRVVERLLSLPVEYWSQFMISDHDHARNDHMIIENANVHTTPDQKMSMFGPITTPDQQMSKTPSSSSLSQRMKNATLNAITPKFSSRSRATAAVPRQGNFFASPLLK
Protein: Uncharacterized WD repeat-containing protein C2A9.03 (Q9Y7K5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSNGEFIDQYLLPESGAILQDYLDDYFYTSWYTGNRNLIQLDHYGFPTASNFELNPKSTDNCGTVDFQGIPWGNKAIGKRKNFRLYRLHTYSLSCNHSDWSPEELSLDTVQVAAEDSFYEFQRFLKNPNCLRNHHHLCKSVKVVGEHSVIYVSNNSIRMENTLHDNSVQIIDLKNNILQKKAISCLDTTNAVGCLGTLYGQYCIFNFKNGSFSTRKLSDDSINHIQLFSEKKFILGCNDGAVYVEDVQRTSPILVYRCSNAVNCVQLFDETPLALVCTDSKDAMLIDIRSNSVSAKLPHSDSVLTGSWHPNGNILATGGQDTTAKVWDIRALGKSFRNLGSQMSAVTNLCFSPLGESLAVTEQADFVQLFDTKLFNTSQVIDFFGEIAGTAYSSSGDSLFIGVDDPMLGGILEFRRPLQHPLSFIF