wanglab/gogpt-training-data huggingface dataset:
Protein: Threonine synthase-like 2 (TSH2) (mTSH2) (EC 4.2.3.-) (Q80W22)
Organism: Mus musculus (Mouse)
Function: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate. Also degrades O-phospho-homoserine (PHS), but this is not its physiological substrate.
Interaction partners:
- Delta-1-pyrroline-5-carboxylate synthase
Sequence:
MWYTSTRGMAPRVNFEGALFSGYAPDGGLYMPEELPRLDEETLRHWSTLSYRSLVKELCALFIGLELIPRHDLNDLIDRAFSRFRHRNVVHLCKLKNGLNILELWHGVTYAFKDLSLSCTAQFLQYFLEKKKKHVTIVVGTSGDTGSAAIESVQGSKNVDIIVLLPKGHCSKIQELQMTTVLKENVHVFEVEGNSDELDEPIKAVFADVAFVQRHNVMSLNSINWSRVLVQMAHHFFAYFQCTPSLDTHPLPTVEVVVPTGAGGNLAAGCIAQKMGLPICLVVAVNRNDIIHRTVQKGDFSLCEVLRTTLASAMDIQVPYNMERIFWLLSGSDSQTTRALMEQFERTQSLQLPKDLHNKLSEAVTSESVTDEAITQTMARCWEENQYLLCPHSATAVNYHYQQTDSGQSSIRCCLASASAVKFPEAVQAAGLTPETPAEILALEHKETRCIPMRRGDDWTQMLRVTIEGLSQRWKDCVVNPSE
Protein: Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.1.-) (Q9H089)
Organism: Homo sapiens (Human)
Function: GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16209721}. Endoplasmic reticulum {ECO:0000269|PubMed:16209721}. Nucleus, Cajal body {ECO:0000269|PubMed:16209721}. Note=Shuttles between the Cajal bodies in the nucleus and the endoplasmic reticulum.
Interaction partners:
- 60S ribosomal export protein NMD3
- Eukaryotic translation initiation factor 6
- Proliferation-associated protein 2G4
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL27
- Cytoplasmic 60S subunit biogenesis factor ZNF622
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- Large ribosomal subunit protein uL3
- GTP-binding protein 4
- Large ribosomal subunit protein uL2
Sequence:
MGRRRAPAGGSLGRALMRHQTQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLDDFLATAELAGTEFVAEKLNIKFVPAEARTGLLSFEESQRIKKLHEENKQFLCIPRRPNWNQNTTPEELKQAEKDNFLEWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCEDLECYVKEMDANKENVILINKADLLTAEQRSAWAMYFEKEDVKVIFWSALAGAIPLNGDSEEEANRDDRQSNTTKFGHSSFDQAEISHSESEHLPARDSPSLSENPTTDEDDSEYEDCPEEEEDDWQTCSEEDGPKEEDCSQDWKESSTADSEARSRKTPQKRQIHNFSHLVSKQELLELFKELHTGRKVKDGQLTVGLVGYPNVGKSSTINTIMGNKKVSVSATPGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMTCSGILPIDQMRDHVPPVSLVCQNIPRHVLEATYGINIITPREDEDPHRPPTSEELLTAYGYMRGFMTAHGQPDQPRSARYILKDYVSGKLLYCHPPPGRDPVTFQHQHQRLLENKMNSDEIKMQLGRNKKAKQIENIVDKTFFHQENVRALTKGVQAVMGYKPGSGVVTASTASSENGAGKPWKKHGNRNKKEKSRRLYKHLDM
Protein: 4-hydroxy-tetrahydrodipicolinate reductase (HTPA reductase) (EC 1.17.1.8) (P04036)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. Can use both NADH and NADPH as a reductant, with NADH being twice as effective as NADPH.
Subcellular location: Cytoplasm.
Interaction partners:
- 4-hydroxy-tetrahydrodipicolinate synthase
- 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
- Diaminopimelate decarboxylase
- Diaminopimelate epimerase
- Carbamoyl phosphate synthase small chain
- Lysine-sensitive aspartokinase 3
- Aspartate-semialdehyde dehydrogenase
- Carbamoyl phosphate synthase large chain
- Succinyl-diaminopimelate desuccinylase
- Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE
Sequence:
MHDANIRVAIAGAGGRMGRQLIQAALALEGVQLGAALEREGSSLLGSDAGELAGAGKTGVTVQSSLDAVKDDFDVFIDFTRPEGTLNHLAFCRQHGKGMVIGTTGFDEAGKQAIRDAAADIAIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAHALDKDLKDCAVYSREGHTGERVPGTIGFATVRAGDIVGEHTAMFADIGERLEITHKASSRMTFANGAVRSALWLSGKESGLFDMRDVLDLNNL
Protein: NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) (A2AQ99)
Organism: Mus musculus (Mouse)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}.
Interaction partners:
- Dual oxidase maturation factor 2
- Neutrophil cytosol factor 2
- Cytochrome b-245 light chain
- NADPH oxidase 1
- NAD
- Neutrophil cytosol factor 4
- Neutrophil cytosol factor 1
- Dual oxidase maturation factor 1
- NADPH oxidase 3
- NADPH oxidase organizer 1
Sequence:
MLPTSPKTLVLLGALLTGPLGPAGGQDAPSLPWEVQRYDGWFNNLKYHQRGAAGSRLRRLIPANYADGVYQALEEPLLPNPRRLSDAVAKGKAGLPSVHNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDHNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQSSLLMWMAPDPSTGRGGPQGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIALYQWLPSFLQKTPPEYSGYRPFMDPSISPEFVVASEQFLSTMVPPGVYMRNSSCHFRKFPKEGSDSSPALRVCNSYWIRENPNLKTAQDVDQLLLGMASQISELEDRIVIEDLRDYWPGPERFSRTDYVASSIQRGRDMGLPSYSQALLALGLEPPKNWSALNPQVEPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSNIILDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTTLRDVLVAVSNVDPSALQPNVFFWQEGAPCPQPRQLTTDGLPQCAPVTVIDYFEGSGAGYGVTLVAVCCFPLVSLIVAGVVAHFRNREHKMLLKKGKESLKKQPASDGVPAMEWPGPKEKSYPVTLQLLPDRSLQVLDKRFTVLRTIQLQSPQQVNLILSSNSGRRTLLLKIPKEYDLVLMFNSEEDRGAFVRLLQDLCICCTPGLHIAEVDEKELLRKAVTKQQRAGILEIFFRQLFAQVLDINQADAGTLPLDSSQQVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYISFREFLDILVVFMKGSSEDKSRLMFTMYDLDGNGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGGAGGTKDIFKQSSACRVSFINRTPGNRVMGPSPRLYTEALQEKKQSGFLAQKFKQYKRFVENYRRHIVCVTIFSAICIGLFADRAYYYGFASPPTDIEETTYVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRWIAMAAVVLAVLHSAGHAVNVYIFSVSPLSLMACVFPNVFVNDGSKFPPKYYWWFFETVPGMTGVLLLLVLAIMYVFASHHFRRHSFRGFWLTHHLYVVLYVLIIIHGSYALIQLPSFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPKTFEYKSGQWVRIACLDLGTNEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSPPVGGTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSMGSQMLCKKIYFIWVTRTQRQFEWLADIIREVEENDCQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKALNRSLFTGLRSITHFGRPPFELFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRAHFVHHYENF
Protein: Truncated geminin (B0LHV2)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNSKMKQSLNVENPSGSLQKYLTDTACSAAPRRTLKMIQPSAKGFLVGRCNEKKSSVNRKLWNNRLTSSACKAEASVDKEQENENTDDVIQAIDLIKKSPSSQYWKEVAEERRKALYEVLQENEKLHKEIEQKDGEIARLKEENEELMSLAEHVHYLTSMIERLTGQESDNLEALESLALDESNQENEDLNLGGDADSTSEGPSQVSCDLRKSVSDLASSEGNY
Protein: At4g24275 (Q84R17)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transcription factor AS1
Sequence:
MSGYSKMDSTDQKLEPDHPVVDPQIQKPDLEPAEMKPKLSRNRSVSASAQAVPSPIKMSMRRSSSVSERYCRIYDQSSATTWPLPFHEGDEDEDDDDKEKVHKKKKSNNFKKKAFVKACKRFFGIS
Protein: Coiled-coil domain-containing protein 13 (Q8IYE1)
Organism: Homo sapiens (Human)
Function: Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24816561}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24816561}.
Interaction partners:
- Beta-alanine-activating enzyme
- Acyl carrier protein, mitochondrial
- Partner and localizer of BRCA2
Sequence:
MAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFRMYHEILGQVKSVFLQALRQQKTGKQ
Protein: ATMRK1 (Protein kinase superfamily protein) (O22100)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASGGGEADKSLEIGSGTADPKIGGTGSRSAGEERYFRADTLDFSKWDLHMGQTSTSSVLTNSASTSAPAPAMQEWEIDLSKLDMKHVLAHGTYGTVYRGVYAGQEVAVKVLDWGEDGYATPAETTALRASFEQEVAVWQKLDHPNVTKFIGASMGTSDLRIPPAGDTGGRGNGAHPARACCVVVEYVAGGTLKKFLIKKYRAKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENMLLQPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHRNLRPEIPKCCPHAVANIMKRCWDPNPDRRPEMEEVVKLLEAIDTSKGGGMIAPDQFQGCLCFFKPRGP
Protein: C-X-C motif chemokine 11 (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11) (Q9JHH5)
Organism: Mus musculus (Mouse)
Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses (By similarity).
Subcellular location: Secreted.
Interaction partners:
Sequence:
MNRKVTAIALAAIIWATAAQGFLMFKQGRCLCIGPGMKAVKMAEIEKASVIYPSNGCDKVEVIVTMKAHKRQRCLDPRSKQARLIMQAIEKKNFLRRQNM
Protein: Gp43, RepA like protein (Q3V5F2)
Organism: Corynebacterium phage BFK20
Interaction partners:
Sequence:
MLGSTMLTTLLGAPPQATADTATIKRYAGMLMKEAGLHLLLVQPGTKVPADMRNAKEKEADVQAGKRAGVYLATNDKRTLDKYIGRYRKAPLNRPSKVNPSGYGEDAPVSLGVHLGPSRLVVIDADTPEEVEALKTYWANAEGIDRAYIPHMTVATPGQTDAQGNKVHSEGGHWYFTLPDGYDINPMTVPSAIAVTVEGVGQFTVKTGNSYVLIPPSEREGRAYTMCAPDQPAPLWLLQLIKERENTAAADPQGARAERDRAEREYREAQARALGQSPTPAVETEHKVNPADLFQHGIGEPREEVQPKQAEQQAPEEVQQQRGAGQDTVQARQVESQPSPLFQHGIADPDELDDETETYKRWDGDTLDEQLDSWSLETSWDDILDPHGWTDSGRTDSCGCRIWTRPDNEMGPSSTYKSMTTHESGCHRERTDNAHPACHVWTEHPGYAIQALLDRVSTRTVSKFSLYTALNHANDYDEAYTELGIDKALVGGGTLLDLAMMGQAGGLDDSRPSTDAERMAQEDSVTPASAPAPEQWVEPVDVAPQTVEEDTFKLPYMGLFTDGAVVTPSGRDVFEEWGLPRPDKEHEDGTVSDEWKKQVPSFGSFQAFRDMPAVKWTLDGWLERGGLLSLIGPSGVGKSAVVLDIACSIASGLGHWQGIKCDSHPVIYVAGEGVTGAVERVTAWERANNMVGALDNKLYVVPESVSLNAPPLTWAYISHLARGVGAGLIVLDTFARMSSGLEENSSKDMTVAVNRLDKVRRTSGAGVLVVHHTTRGATHGRGSTALNGAMDSEILLTKPEQEVKDGNREDPRLTDNEGDEVRGKGVVMRLTKQKNGPDGYTREVVLTEEEDVRIDHMYAPALKTGMVVTDVNGRPASYRTDYLQGEAPRHFAPPKPEKVEVTAQRVLDFISEFRTLELTTTSIRNGVEPDVYHKDKMKMWATHLQRVLDLLVTQGKLERDGRTSFKRPDEYVTVDSERETARP
Protein: Probable RNA-binding protein 19 (RNA-binding motif protein 19) (Q8R3C6)
Organism: Mus musculus (Mouse)
Function: Plays a role in embryo pre-implantation development.
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Chromosome. Note=Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to nucleolar precursor body (NPB) (By similarity). In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the NPB. During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development. {ECO:0000250}.
Interaction partners:
- BMS1 homolog, ribosome assembly protein
- Periodic tryptophan protein 2 homolog
- U3 small nucleolar ribonucleoprotein protein IMP4
- Protein RRP5 homolog
- Pescadillo homolog
- Protein AATF
- Ribosome biogenesis protein WDR12
- Surfeit locus protein 6
- Bystin
- Probable ATP-dependent RNA helicase DDX10
Sequence:
MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQAALNHFHRSFIDTTRITVEFCKSFGDPSKPRAWSKHAQKSSQPKQPSQDSVPSDTKKDKKKKGPSDLEKLKEDAKFQEFLSIHQKRTQVATWANDALEAKLPKAKTKASSDYLNFDSDSNSDSGQESEEEPAREDPEEEQGLQPKAAVQKELSDMDYLKSKMVRAEVSSEDEDEEDSEDEAVNCEEGSEEEEEEGSPASPAKQGGVSRGAVPGVLRPQEAAGKVEKPVSQKEPTTPYTVKLRGAPFNVTEKNVIEFLAPLKPVAIRIVRNAHGNKTGYVFVDLSSEEEVKKALKCNRDYMGGRYIEVFREKQAPTARGPPKSTTPWQGRTLGENEEEEDLADSGRLFVRNLSYTSSEEDLEKLFSAYGPLSELHYPIDSLTKKPKGFAFVTFMFPEHAVKAYAEVDGQVFQGRMLHVLPSTIKKEASQEANAPGSSYKKKKEAMDKANSSSSHNWNTLFMGPNAVADAIAQKYNATKSQVFDHETRGSVAVRVALGETQLVQEVRSFLIDNGVCLDSFSQAAAERSKTVILAKNLPAGTLAAEIQETFSRFGSLGRVLLPEGGITAIVEFLEPLEARKAFRHLAYSKFHHVPLYLEWAPIGVFGAAPQKKDSQHEQPAEKAEVEQETVLDPEGEKASVEGAEASTGKMEEEEEEEEEEEEESIPGCTLFIKNLNFSTTEETLKGVFSKVGAIKSCTISKKKNKAGVLLSMGFGFVEYKKPEQAQKALKQLQGHTVDGHKLEVRISERATKPALTSTRKKQVPKKQTTSKILVRNIPFQANQREIRELFSTFGELKTVRLPKKMTGTGAHRGFGFVDFITKQDAKKAFNALCHSTHLYGRRLVLEWADSEVTVQTLRRKTARHFQEPPKKKRSAVLDGILEQLEDEDNSDGEQALQL
Protein: Ribonuclease kappa (RNase K) (RNase kappa) (EC 3.1.-.-) (V-type proton ATPase subunit f) (V-ATPase subunit f) (Q6P5S7)
Organism: Homo sapiens (Human)
Function: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate. Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments. Required at an early stage of receptor-mediated endocytosis.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:26212330}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q3ZC23}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- V-type proton ATPase subunit S1
- V-type proton ATPase 16 kDa proteolipid subunit c
- Renin receptor
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit D
- V-type proton ATPase subunit F
- V-type proton ATPase subunit H
- V-type proton ATPase subunit e 1
Sequence:
MGWLRPGPRPLCPPARASWAFSHRFPSPLAPRRSPTPFFMASLLCCGPKLAACGIVLSAWGVIMLIMLGIFFNVHSAVLIEDVPFTEKDFENGPQNIYNLYEQVSYNCFIAAGLYLLLGGFSFCQVRLNKRKEYMVR
Protein: ABC transporter C family member 13 (OsABCC13) (EC 7.-.-.-) (Multidrug resistance-associated protein 13) (OsMRP13) (OsMRP5) (Protein LOW PHYTIC ACID 2) (Q10RX7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: ABC transporter that may affect phytic acid transport and compartmentalization. May function directly or indirectly in removing phytic acid from the cytosol or in vesicle trafficking. Required for phytic acid accumulation in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Os01g0314700 protein
- Inositol 3-kinase
Sequence:
MPHFPNLPLPEAAAAAAHAALLALALLLLLLRSARALASRCASCLKTAPRRAAAVDGGLAAASSVGAWYRAALACCGYALLAQVAALSYEVAVAGSHVAVEALLLPAVQALAWAALLALAMQARAVGWGRFPVLVRVWWVVSFVLCVGIAYDDTRHLMGDDDDDEVDYAHMVANFASAPALGFLCLVGVMGSTGVELEFTDDDSSVHEPLLLGGQRRDADEEPGCLRVTPYGDAGIVSLATLSWLSPLLSVGAQRPLELADIPLMAHKDRAKSCYKAMSSHYERQRMERPGSEPSLAWAILKSFWREAAINGAFAAVNTIVSYVGPYLISYFVDYLSGKIEFPHEGYILASVFFVAKLLETLTARQWYLGVDVMGIHVKSGLTAMVYRKGLRLSNSSRQSHTSGEIVNYMAVDVQRVGDYAWYFHDIWMLPLQIILALAILYKNVGIAMVSTLVATVLSIAASVPVAKLQEHYQDKLMASKDERMRKTSECLKNMRILKLQAWEDRYRLKLEEMRNVECKWLRWALYSQAAVTFVFWSSPIFVAVITFGTCILLGGELTAGGVLSALATFRILQEPLRNFPDLISMIAQTRVSLDRLSHFLQQEELPDDATITVPHGSTDKAININDATFSWNPSSPTPTLSGINLSVVRGMRVAVCGVIGSGKSSLLSSILGEIPKLCGQVRISGSAAYVPQTAWIQSGNIEENILFGSPMDKQRYKRVIEACSLKKDLQLLQYGDQTIIGDRGINLSGGQKQRVQLARALYQDADIYLLDDPFSAVDAHTGSELFREYILTALASKTVIYVTHQIEFLPAADLILVLKDGHITQAGKYDDLLQAGTDFNALVCAHKEAIETMEFSEDSDEDTVSSVPIKRLTPSVSNIDNLKNKVSNNEKPSSTRGIKEKKKKPEERKKKRSVQEEERERGRVSLQVYLSYMGEAYKGTLIPLIILAQTMFQVLQIASNWWMAWANPQTEGDAPKTDSVVLLVVYMSLAFGSSLFVFVRSLLVATFGLATAQKLFVKMLRCVFRAPMSFFDTTPSGRILNRVSVDQSVVDLDIAFRLGGFASTTIQLLGIVAVMSKVTWQVLILIVPMAVACMWMQRYYIASSRELTRILSVQKSPVIHLFSESIAGAATIRGFGQEKRFMKRNLYLLDCFARPLFSSLAAIEWLCLRMELLSTFVFAFCMAILVSFPPGTIEPSMAGLAVTYGLNLNARMSRWILSFCKLENRIISVERIYQYCKLPSEAPLIIENSRPSSSWPENGNIELVDLKVRYKDDLPLVLHGISCIFPGGKKIGIVGRTGSGKSTLIQALFRLIEPTGGKVIIDDVDISRIGLHDLRSRLSIIPQDPTLFEGTIRMNLDPLEECTDQEIWEALEKCQLGEVIRSKDEKLDSPVLENGDNWSVGQRQLIALGRALLKQAKILVLDEATASVDTATDNLIQKIIRSEFKDCTVCTIAHRIPTVIDSDLVLVLSDGKIAEFDTPQRLLEDKSSMFMQLVSEYSTRSSCI
Protein: Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) (Q70EL1)
Organism: Homo sapiens (Human)
Function: Has no peptidase activity.
Interaction partners:
Sequence:
MSWKRNYFSGGRGSVQGMFAPRSSTSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKGIFNQFQCSSEKVLPSDTLRSALAKTFQDEQRFQLGIMDDAAECFENLLMRIHFHIADETKEDICTAQHCISHQKFAMTLFEQCVCTSCGATSDPLPFIQMVHYISTTSLCNQAICMLERREKPSPSMFGELLQNASTMGDLRNCPSNCGERIRIRRVLMNAPQIITIGLVWDSDHSDLAEDVIHSLGTCLKLGDLFFRVTDDRAKQSELYLVGMICYYGKHYSTFFFQTKIRKWMYFDDAHVKEIGPKWKDVVTKCIKGHYQPLLLLYADPQGTPVSTQDLPPQAEFQSYSRTCYDSEDSGREPSISSDTRTDSSTESYPYKHSHHESVVSHFSSDSQGTVIYNVENDSMSQSSRDTGHLTDSECNQKHTSKKGSLIERKRSSGRVRRKGDEPQASGYHSEGETLKEKQAPRNASKPSSSTNRLRDFKETVSNMIHNRPSLASQTNVGSHCRGRGGDQPDKKPPRTLPLHSRDWEIESTSSESKSSSSSKYRPTWRPKRESLNIDSIFSKDKRKHCGYTQLSPFSEDSAKEFIPDEPSKPPSYDIKFGGPSPQYKRWGPARPGSHLLEQHPRLIQRMESGYESSERNSSSPVSLDAALPESSNVYRDPSAKRSAGLVPSWRHIPKSHSSSILEVDSTASMGGWTKSQPFSGEEISSKSELDELQEEVARRAQEQELRRKREKELEAAKGFNPHPSRFMDLDELQNQGRSDGFERSLQEAESVFEESLHLEQKGDCAAALALCNEAISKLRLALHGASCSTHSRALVDKKLQISIRKARSLQDRMQQQQSPQQPSQPSACLPTQAGTLSQPTSEQPIPLQVLLSQEAQLESGMDTEFGASSFFHSPASCHESHSSLSPESSAPQHSSPSRSALKLLTSVEVDNIEPSAFHRQGLPKAPGWTEKNSHHSWEPLDAPEGKLQGSRCDNSSCSKLPPQEGRGIAQEQLFQEKKDPANPSPVMPGIATSERGDEHSLGCSPSNSSAQPSLPLYRTCHPIMPVASSFVLHCPDPVQKTNQCLQGQSLKTSLTLKVDRGSEETYRPEFPSTKGLVRSLAEQFQRMQGVSMRDSTGFKDRSLSGSLRKNSSPSDSKPPFSQGQEKGHWPWAKQQSSLEGGDRPLSWEESTEHSSLALNSGLPNGETSSGGQPRLAEPDIYQEKLSQVRDVRSKDLGSSTDLGTSLPLDSWVNITRFCDSQLKHGAPRPGMKSSPHDSHTCVTYPERNHILLHPHWNQDTEQETSELESLYQASLQASQAGCSGWGQQDTAWHPLSQTGSADGMGRRLHSAHDPGLSKTSTAEMEHGLHEARTVRTSQATPCRGLSRECGEDEQYSAENLRRISRSLSGTVVSEREEAPVSSHSFDSSNVRKPLETGHRCSSSSSLPVIHDPSVFLLGPQLYLPQPQFLSPDVLMPTMAGEPNRLPGTSRSVQQFLAMCDRGETSQGAKYTGRTLNYQSLPHRSRTDNSWAPWSETNQHIGTRFLTTPGCNPQLTYTATLPERSKGLQVPHTQSWSDLFHSPSHPPIVHPVYPPSSSLHVPLRSAWNSDPVPGSRTPGPRRVDMPPDDDWRQSSYASHSGHRRTVGEGFLFVLSDAPRREQIRARVLQHSQW
Protein: Probable WRKY transcription factor 43 (WRKY DNA-binding protein 43) (Q8GY11)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- RING/FYVE/PHD zinc finger superfamily protein
Sequence:
MNGLVDSSRDKKMKNPRFSFRTKSDADILDDGYRWRKYGQKSVKNSLYPRSYYRCTQHMCNVKKQVQRLSKETSIVETTYEGIHNHPCEELMQTLTPLLHQLQFLSKFT
Protein: UPF0208 membrane protein YfbV (P0A8D9)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Der GTPase-activating protein YihI
- Negative modulator of initiation of replication
- UPF0352 protein YejL
- Protein Syd
- RNA chaperone ProQ
- Universal stress protein E
- Regulator of ribonuclease activity B
- DNA mismatch repair protein MutH
- Uncharacterized protein YheV
- HTH-type transcriptional repressor FabR
Sequence:
MSTPDNRSVNFFSLFRRGQHYSKTWPLEKRLAPVFVENRVIKMTRYAIRFMPPIAVFTLCWQIALGGQLGPAVATALFALSLPMQGLWWLGKRSVTPLPPAILNWFYEVRGKLQESGQVLAPVEGKPDYQALADTLKRAFKQLDKTFLDDL
Protein: Uncharacterized HTH-type transcriptional regulator YfjR (P52133)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Lipoprotein YfjS
Sequence:
MTQAERRHDRLAVRLSLIISRLVAGETLSVRKLAAEFGVSVRTLRRDFRERLMYLDLEYQSGYCRLRTAGSEMQMVPDVLIFAHRSGLAGLFPGLDRRLVNALLMCDESPCVIAPANPVPSPSGALSFWRLIQAITGRRRVTLIAEGRRCERLAPCRLLIHQQTWYLVAEHEGHIAVFTLDEIHLIQPLQETFRRNDSLCRLVEDPVFIQALPHFRFIQHSLLTFVPADSPPE
Protein: EGF like, fibronectin type III and laminin G domains (D6RJD2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTN
Protein: Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (mMof) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-) (Q9D1P2)
Organism: Mus musculus (Mouse)
Function: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (Probable). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120' (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:28506985, ECO:0000305|PubMed:31794431}. Chromosome {ECO:0000269|PubMed:23523075, ECO:0000269|PubMed:24842875, ECO:0000269|PubMed:24898753, ECO:0000305|PubMed:31794431}. Mitochondrion {ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:37813994}. Note=Translocated into the nucleus via its association with importin-alpha-1 (KPNA2) (By similarity). As part of the NSL complex, associates with the proximal part of promoters and transcription start sites (PubMed:23523075, PubMed:24842875, PubMed:24898753). As part of the MSL complex, associates with gene bodies (PubMed:24898753). Also localizes to mitochondria; associates with mitochondrial DNA and regulates mitochondrial gene expression (PubMed:27768893). {ECO:0000250|UniProtKB:Q9H7Z6, ECO:0000269|PubMed:23523075, ECO:0000269|PubMed:24842875, ECO:0000269|PubMed:24898753, ECO:0000269|PubMed:27768893}.
Interaction partners:
- Male-specific lethal 1 homolog
- MSL complex subunit 3
- KAT8 regulatory NSL complex subunit 1
- PHD finger protein 20
- E3 ubiquitin-protein ligase MSL2
- KAT8 regulatory NSL complex subunit 3
- WD repeat-containing protein 5
- Microspherule protein 1
- KAT8 regulatory NSL complex subunit 2
- Transformation/transcription domain-associated protein
Sequence:
MAAQGATAAVAATTSGTVGEGEPGPGENAAVEGPARSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKFEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
Protein: Keratin-associated protein 21-3 (Q3LHN1)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 21-2
- Keratin-associated protein 21-1
Sequence:
MYFNYKSVCGSCGFGSCYGCGYGCIHSTHCGCNGYYGCYENKYSVIDDLIFFASKKCH
Protein: Mannose-specific lectin (Agglutinin) (NPA) (NPL) (NPL7) (NPn) (C0HM45)
Organism: Narcissus pseudonarcissus (Daffodil)
Function: D-mannose-binding lectin which binds alpha-D-linked mannose. Displays a high affinity for alpha-(1-6)-mannose oligomers. Able to interact with both terminal and internal alpha-D-mannosyl residues. Displays antiviral activity and therefore may contribute to defense against infections.
Subcellular location: Secreted {ECO:0000269|PubMed:10388566}.
Interaction partners:
Sequence:
DNILYSGETLSPGEFLNNGRYVFIMQEDCNLVLYDVDKPIWATNTGGLDRRCHLSMQSDGNLVVYSPRNNPIWASNTGGENGNYVCVLQKDRNVVIYGTARWATGTNIH