wanglab/gogpt-training-data huggingface dataset:
Protein: Anaphase-promoting complex subunit 1 (APC1) (Metaphase-to-anaphase transition protein 2) (O18191)
Organism: Caenorhabditis elegans
Function: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion. Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons.
Interaction partners:
- Anaphase-promoting complex subunit 2
- Cell division cycle protein 16 homolog
- Abnormal embryogenesis protein 30
- Anaphase-promoting complex subunit 11
- Cell division cycle protein 23 homolog
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 10
- WD repeat-containing protein fzy-1
- Suppressor of spindle checkpoint defect 1
- Protein gfi-3
Sequence:
MRKYVLFFISGNNDSQIWATTPNTPRVIARGGLERNIHTRTLARMVNEDAPGTSTPAAQSRLQTTASPFHRTHLTQMCRRGDTNASLLRDFTRMIRDTPRNFSKNTQHGNDRDFGDLERDPDVDLLLSKVCLECVYVEPKEGAIPKANKIFISNFLSDMYINLVSVTGEVMKIIPIWKNAETTRKNLLEKGKHEPCVVDCVDAAFVMKSGITVVLGSDFTTAMFGGNERIAPIFIKEMSNQRVGRKFRLFSFAENRIFAVNEMRCIVVEIPETVTCKSATELMRTCFLHLDRDLSRKLLIKWRSVKRDVDTERLDLDRKEMIDVAIFMLDNVGVRVTNVVAQERADSPEGHGGKQMRPRMSDSEVLSMMRQFFEEMTFRPKSEVITEDGYKCHLSVELDPNGEGFVHTQDLLHAFHSQCEDWSINTMMHSILLELIPYAYLLAKVMNYRAFEEYYVQLFKHLLSQIAIEFKIPPEIHEKFVGAIHIPKPCWSLNNVIAHIICERTTPETMESIPKFISKSSVRLLTILAVGRKFIGMGTNIDMDCERWLGKDWKRRIGLSGDILKSFRRIMNGKSSNSAGRASQLIELFEIGSITIDFMVLAVKVLMLKFQTDAFAGAQSIEPKKCIYATADEMISIAHLRWKNDIRMHNVQLMLNSSRPILIATNILRKNEDDNMKELQDRFLTQTSYRTFSQPFGRAFLDFRTAVPSLLTSIYIPRLNVGGMIYPSRVTCDPPTTEIFKLCTEWGNFYNSLASALRIGSSETVRIDNEWIVMVSKNIKSTAVIGGMTLGFGLNGHLAPFNMYHAHQMLSTFDKFHSVALLIGLSASNFTTCDVQIHKILATYLSFLMGPTPLEIKLDFTIQTAAISGLGLLFADSGNMTIAKKLVNEIGRAPNRDEEPVTDRNAYKLSAGFSLGLIMLGKGNGSASTVIPFKQNIPPMSQRLIYMMNGMRRDKCVFLPQVAPPVVNDVPNLPFSNGGMMTSSQVANHVKESEYINIHQSAEPAAIALGMMFMKMNNEFIANALALPGTITELERLKPDSMYSRVLAQCLVMWDSIEPTHDFVKSLIPPVIREYATAALHFGVPIRRDEDGEEVHEAINDAEEKYWAEIVDKGTVSQTFLYAVSAACMAIALKFSSCGGPNEKNIVNTAFRIIEYYTKIVMPDGKSNKDMGSIRMCIYSGAYTRTSCLSMLITAMAILRVGTGDLEVMRYARLLRLCDKPESDWIATGKKHFEQMVAHQALGILMLGEGRYAFKKDDLSIALTIISTFPTIPQSVSDNSHYHQPLRFLWSMAVEPRLLVPFDIAESCVVEVDVTIVMKPKDGNEPIVYKEKAPYLLPPLEDLQSISIGGGNYQLVHISLQSEDQVKVMKDIMTIGQGRVMLKRYGVDSSEMKIKEATTLYDDTPSLMSMFNNEDTAVELDEYEIQCMMEKIDEGINLNSSDEYPNVQIELSCVRDVTERTTMDLAQLQKRSLKLLSESLDLWQDEVNVSNTINGLADAVQDMQI
Protein: Actin-regulating kinase PRK1 (EC 2.7.11.1) (p53-regulating kinase 1) (P40494)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protein kinase involved in the regulation of actin cytoskeleton organization and endocytosis. Phosphorylates PAN1 which disrupts the interaction between PAN1 and END3, and between PAN1 and SLA1. Phosphorylates SCD5. Preferentially, phosphorylates substrates on threonine residues in a [L/I/V/M]-x-x-[Q/N/T/S]-x-T-G motif.
Subcellular location: Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:10087264, ECO:0000269|PubMed:14562095}. Note=Cortical actin patches.
Interaction partners:
- Actin-binding protein
- Actin cytoskeleton-regulatory complex protein PAN1
- Actin cytoskeleton-regulatory complex protein SLA1
- Protein SCD5
- Protein SLA2
- Clathrin coat assembly protein AP180A
- Proline-rich protein LAS17
- Actin cytoskeleton-regulatory complex protein END3
- Epsin-1
- Actin-regulating kinase 1
Sequence:
MNTPQISLYEPGTILTVGSHHAKIIKYLTSGGFAQVYTAEISPPDPYSNANIACLKRVIVPHKQGLNTLRAEVDAMKLLRNNKHVVSYIDSHAARSVNGIAYEVFVLMEFCERGGLIDFMNTRLQNRLQESEILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISHDGLYKVCDFGSVSGVIRPPRNTQEFNYVQHDILTNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSGEAGILHARYQYPSFPQYSDRLKNLIRLMLMEAPSQRPNICQVLEEVSRLQNKPCPIRNFYLLRAMNQNANTQLAGEPSSTTYVPTQKFIPVQSLQSINQPPNMMPVTHVSTTPNLGTFPISINDNNKTEVTAHAGLQVGSHSNLTSPLMKTKSVPLSDEFASLYYKELHPFQKSQTFKSVESFQSPQRKSMPPLSLTPVNNDIFDRVSAINRPNNYVDSETQTIDNMAVPNLKLSPTITSKSLSSTKEIAAPDNINGSKIVRSLSSKLKKVITGESRGNSPIKSRQNTGDSIRSAFGKLRHGFTGNSVNNSRSASFDNNNVNGNGNNTNRRLVSSSTSSFPKFNSDTKRKEESDKNQRLEKRRSMPPSILSDFDQHERNNSRTGSRDYYRSHSPVKKTQASAKTTSKPTLIPDNGNVNINQEKKESIQRRVHNLLKSSDDPVTYKSASGYGKYTDIGTETSNRHSSVRITPITEEKFKKTLKDGVLDIKTKSNGKDKSRPPRPPPKPLHLRTEIQKIRNFSRLQSKKLPIERISSEATETIVDVNVDDLEADFRKRFPSKV
Protein: Gamma-secretase subunit APH-1 (APH-1) (Q5PQQ3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}.
Interaction partners:
Sequence:
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFVTAGGSLRSIQRSLSCKD
Protein: A-agglutinin anchorage subunit (A-agglutinin cell wall attachment subunit) (P32323)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cell wall anchoring subunit of the a-agglutinin heterodimer. S.cerevisiae a and alpha cells express the complementary cell surface glycoproteins a-agglutinin and alpha-agglutinin, respectively, which interact with one another to promote cellular aggregation during mating.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:14555493}. Membrane {ECO:0000269|PubMed:14555493}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:14555493}. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Interaction partners:
- A-agglutinin-binding subunit
- Factor-induced gene 2 protein
- Alpha-agglutinin
- Nuclear fusion protein FUS1
- SAGA complex subunit SUS1
- Protein SST2
- SAGA complex subunit SGF73
- Arginine permease CAN1
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
Sequence:
MTLSFAHFTYLFTILLGLTNIALASDPETILVTITKTNDANGVVTTTVSPALVSTSTIVQAGTTTLYTTWCPLTVSTSSAAEISPSISYATTLSRFSTLTLSTEVCSHEACPSSSTLPTTTLSVTSKFTSYICPTCHTTAISSLSEVGTTTVVSSSAIEPSSASIISPVTSTLSSTTSSNPTTTSLSSTSTSPSSTSTSPSSTSTSSSSTSTSSSSTSTSSSSTSTSPSSTSTSSSLTSTSSSSTSTSQSSTSTSSSSTSTSPSSTSTSSSSTSTSPSSKSTSASSTSTSSYSTSTSPSLTSSSPTLASTSPSSTSISSTFTDSTSSLGSSIASSSTSVSLYSPSTPVYSVPSTSSNVATPSMTSSTVETTVSSQSSSEYITKSSISTTIPSFSMSTYFTTVSGVTTMYTTWCPYSSESETSTLTSMHETVTTDATVCTHESCMPSQTTSLITSSIKMSTKNVATSVSTSTVESSYACSTCAETSHSYSSVQTASSSSVTQQTTSTKSWVSSMTTSDEDFNKHATGKYHVTSSGTSTISTSVSEATSTSSIDSESQEQSSHLLSTSVLSSSSLSATLSSDSTILLFSSVSSLSVEQSPVTTLQISSTSEILQPTSSTAIATISASTSSLSATSISTPSTSVESTIESSSLTPTVSSIFLSSSSAPSSLQTSVTTTEVSTTSISIQYQTSSMVTISQYMGSGSQTRLPLGKLVFAIMAVACNVIFS
Protein: Uncharacterized protein (Q3ECW0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT5g05250/K18I23_5
- Transcription factor bHLH101
- Probable plastid-lipid-associated protein 14, chloroplastic
- Oligopeptide transporter 3
- Ferric reduction oxidase 3, mitochondrial
- At1g12030
- Transcription factor ORG3
- At3g56360
- Protein CONSERVED IN THE GREEN LINEAGE AND DIATOMS 27
- Transcription factor bHLH100
Sequence:
MMSFVANLAIKRFDHASTVYVEDVVDSSRVAYSENGGDDDDSGYDYAPAA
Protein: Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) (A0A2R8Q2T0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR000929}.
Interaction partners:
- Si:dkey-237i9.8.
- Growth factor receptor-bound protein 2
- Catenin
- GRB2-associated-binding protein 1
- Tyrosine-protein kinase.
- C-X-C chemokine receptor type 3-2
- B- and T-lymphocyte attenuator-like
- Tyrosine-protein kinase.
- Growth factor receptor-bound protein 2a
Sequence:
MFNRWFHRDLSGLDAEAVLKSRGVHGSFLARPSKKNVGDFSLSVRVGEIITHIRIQNTGDYYDLYGGEKFATLAELVEYYTGDHGTLQDKDGTVIELKYPLNCSDPTTERWYHGHLSGPNAEKLLRERNEPGTFLVRESLSKPGDFVLSALTDDQTSSGRRVSHIKIMCNNDRYTVGGKDQFDNLTDLVEHFKRVGIEELSGTMVYLKQPYYSTRLNAADIQSRVNQLDQTSEREKMDGADKKIKAGFWEEFDALQKLETKVTKSRDEGMRPENKSKNRYKNILPFDETRVILENADPNVVGSDYINANYVINKLMVTNPQKTYIACQGCLATTVDDFWQMMWQEDSRVIVMTTREVEKGRNKCVPYWPTTEGESKEVGRYVVKLLSEMDAADYKVRVVELSAPHRNEAPRKIWHFQYLSWPDHGVPQEPGGVLSFLDQVNRKQEELRSSAPIVIHCSAGIGRTGTIVVIDMLIDSIDAKGLDCDIDIQKCIMMVRDQRSGMVQTEAQYKFIYLAVLQYIESTKVTRRAIMETETEYGNLSIQSKHPKASRKASSKKNEDVYENLGAKGKKDVKKQKSEEKKGGGSVRKR
Protein: cDNA FLJ76839, highly similar to Homo sapiens kelch repeat and BTB (POZ) domain containing 5 (KBTBD5), mRNA (A8K5H9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, myofibril, sarcomere, A band {ECO:0000256|ARBA:ARBA00004161}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000256|ARBA:ARBA00004355}.
Interaction partners:
Sequence:
MALGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSSQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESVPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGVLREIAYAAGATFLPVRLNVLRLTKM
Protein: (-)-5-epieremophilene synthase STPS1 (EC 4.2.3.199) (Sesquiterpene synthase 1) (SmSTPS1) (A0A1W6GW32)
Organism: Salvia miltiorrhiza (Chinese sage)
Function: Sesquiterpene synthase that catalyzes the conversion of farnesyl diphosphate to (-)-5-epi-eremophilene.
Interaction partners:
Sequence:
MATTQAQIQRPIANFSPSLWGDQFIKNDPGAKAAEKHCKAVEELKKEVMNMITAAGSNLVEAMNLIDTLERLGISYHFEKEIDQKLKHFFNLNKDYSDESYDLYTVSLHFRLFRQHGHRISSDIFGRWIDESGKFKEGLKTDGKGLLSLYEASYLRTRGETILDDALEFATATLNSIAPHLESPLSKQVVHALIQPLHYGNPRIEAHNFISIYEENQDKNEFLLRFAKLDYNLLQMLHKEELNEVSRWWKELDLVSKLPYARDRVVECFFWAMGVYHEPQYSRARIMLTKTITMTSIIDDTYDAYGVIEELDIFTEAIERWNMEEMKKLPEYIQPFYKALLELYEQFEEELAEEGRSYAAHYAIESLKELVRSYHVEAKWFIQGYLPPFEEYLKNALITCTYCYHTTTSLLGVESAVEEDFEWLANKPKMLVAGLLICRVIDDIATYEVEKERGQSATGIESYMRDNNATIEEAVAKFFEIATDAWKDINEECLMPSPYSRDVLMRILNLERIIDVTYKGNEDGYTQPEKVLKPHIIALFVDPIKM
Protein: Zinc finger protein 479 (Zinc finger protein Kr19) (HKr19) (Q96JC4)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MAKRPGPPGSREMGLLTFRDIAIEFSLEEWQCLDCAQRNLYRDVMLENYRNLVSLGIAVSKPDLITCLEQNKESQNIKRNEMVAKHPVTRSHFTQDLQPEQGIKDSLQKVIPRTYGKCGHEKLQFKKCCKSVGEYEVHKGGYSEVNQCLSTTQNKIFQTHKYVKVFGKFSNSNRDKTRYTGNKHFKCNKYGKSFCMLSHLNQHQVIHTREKSYKCKECGKSFNCSSNHTTHKIIHTGEKPYRCEECGKAFSWSANLTRHKRTHTGEKPYTCEECGQAFRRSSALTNHKRIHTGERPYKCEECGKAFSVSSTLTDHKRIHTGEKPCRCEECGKAFSWSSNLTRHKRIHTREKPYACEECGQAFSLSSNLMRHRRIHTGEKPYTCEECGQDFRRSSALTIHKRIHTGERPYKCEECGKVFSLSSTLTDHKRIHTGERPYKCEECGKAFSLSSTLTDHKRIHTGERPYTCEECGKAFNCSSTLMQHKRIHTGEKPYKCEECEQAFKWHSSLAKHKIIHTGEKPYKCE
Protein: Ankyrin 2 (A0A5F9ZHM6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKSGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Protein: Bifunctional aspartate aminotransferase and L-aspartate beta-decarboxylase (EC 2.6.1.1) (EC 4.1.1.12) (Aspartate 4-decarboxylase) (ASD) (AsdA) (Q93QX0)
Organism: Comamonas testosteroni (Pseudomonas testosteroni)
Function: Bifunctional enzyme that has both L-aspartate decarboxylase and transaminase activity.
Interaction partners:
Sequence:
MSKDYQSLAKLSPFELKDELIKIASSDGNRLMLNAGRGNPNFLATTPRRAFFRLGLFAAAESELSYSYMTTVGVGGLAKIDGIEGRFERYIAENRDQEGVRFLGKSLSYVRDQLGLDPAAFLHEMVDGILGCNYPVPPRMLNISEKIVRQYIIREMGADAIPSESVNLFAVEGGTAAMAYIFESLKLNGLLKAGDKVAIGMPVFTPYIEIPELAQYALEEVAINADPSLNWQYPDSELDKLKDPAIKIFFCVNPSNPPSVKMDQRSLERVRNIVAEHRPDLMILTDDVYGTFADDFQSLFAICPENTLLVYSFSKYFGATGWRLGVVAAHQQNVFDLALDKLQESEKVALDHRYRSLLPDVRSLKFIDRLVADSRAVALNHTAGLSTPQQVQMALFSLFALMDEADEYKHTLKQLIRRRETTLYRELGMPPLRDENAVDYYTLIDLQDVTAKLYGEAFSEWAVKQSSTGDMLFRIADETGIVLLPGRGFGSNRPSGRASLANLNEYEYAAIGRALRKMADELYAEYSGQAQNL
Protein: Protein Wnt (G3V819)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
- Frizzled-6
- Frizzled-3
- Frizzled-4
- Frizzled class receptor 7
- Frizzled-9
- Frizzled-2
- Frizzled-8
- Receptor-like tyrosine kinase.
- Frizzled-1
- Frizzled-5
Sequence:
MRARPQVCEALLFALALHTGVCYGIKWLALSKTPAALALNQTQHCKQLEGLVSAQVQLCRSNLELMRTIVHAAREAMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAATISHTIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLETKCKCHGVSGSCSIRTCWKGLQELRDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK
Protein: Homeobox protein php-3 (Posterior Hox protein paralog 3) (Q9XW88)
Organism: Caenorhabditis elegans
Function: Probable transcription factor, involved in posterior embryonic patterning, morphogenetic movements of the posterior hypodermis, and cell fate specification. May regulate expression of transcription factor dmd-3.
Subcellular location: Nucleus {ECO:0000255|RuleBase:RU000682}.
Interaction partners:
- Homeobox protein ceh-40
- Homeobox protein ceh-20
- Homeobox protein unc-62
- Homeobox protein ceh-60
- Homeobox protein lin-39
- Homeobox protein egl-5
- Homeobox protein mab-5
Sequence:
MISVMQQMMNNSNMPPPFVKSSDSHETHDESPTSPFIKRSDSPATTSSAAAAAMQHNFWSTRAAQLQQSVSGSSGVSSGSSSSASNNLSRTQADNHSERGSDTASSPQVAPLPTSSGMSMPAAAAAGMYPFNAGRFPTEFNMMVNQSMYNDFYSNSLAASSWPYSYPQQYPFANYSMPSLDGNLNDGGQLEWTSSSHAMRKKRKPYTKAQTLELEKEFLYNTYVSKQKRWELAKYLHLTERQVKIWFQNRRMKDKKQKQRTSGDPTGMLMPPGLD
Protein: Protein SMAX1-LIKE 8 (AtSMXL8) (Protein D53-like 3) (AtD53-like 3) (Protein D53-like SMXL 8) (F4IGZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable component of a transcriptional corepressor complex involved in branching control. Regulates cotyledon expansion and lateral root growth, but not germination or hypocotyl elongation. Promotes auxin transport and PIN1 accumulation in the stem and represses BRC1/TCP18 expression in axillary buds.
Subcellular location: Nucleus {ECO:0000269|PubMed:26546446}.
Interaction partners:
- F-box protein MAX2
- Probable esterase KAI2
- Strigolactone esterase D14
- Carotenoid cleavage dioxygenase 8, chloroplastic
- Carotenoid cleavage dioxygenase 7, chloroplastic
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD2
- Cytochrome P450 711A1
- ATP-dependent Clp protease adapter protein CLPS1
- Topless-related protein 2
- F-box/kelch-repeat protein SKIP25
Sequence:
MPTAVNVAKQCLTAEASYALEEAVNVARRRGHSQTTSLHAISALLSLPTSVLRDACARVRNSAYSPRLQFKALDLCLSVSLDRIQSGHQLGSDDSPPVSNSLMAAIKRSQAHQRRLPENFRIYQEMSQSQNQNSLSCVKVELRQLILSILDDPVVSRVFGEAGFRSSELKLSIIRPVPHLLRYSSQQPLFLCNLTGNPEPNPVRWGFTVPSLNFNGDLDYRRISAVFTKDKGRNPLLVGVSAYGVLTSYLNSLEKNQTDGMILPTKLHGLTAVNIGSEISDQISVKFDKTYTDTRFHDLGKLAEQGSGPGLLLHYGDLRVFTNGEGNVPAANYIVNRISELLRRHGRRVWLIGATTSNEVYEKMMRRFPNVEKDWDLQLLTITSLKPCLPHNKSSLIGSFVPFGGFFSTTPSELKLPFSGFKTEITGPVSSISDQTQSTLPPWLQMTTRTDLNQKSSAKVVQTKEGLESVCGNKFTSSASASTCSAKSVTTDLNLRVSSVTTGSGLKKHLDSKDFSQPQSVSSYSFDNPRDLNAESFKIIYRRLTDMVSGQDEAARVISCALSQPPKSVTRRDVWLNLVGPDTVGKRRMSLVLAEIVYQSEHRFMAVDLGAAEQGMGGCDDPMRLRGKTMVDHIFEVMCRNPFCVVFLENIEKADEKLQMSLSKAIETGKFMDSHGREVGIGNTIFVMTSSSQGSATTTSYSEEKLLRVKGRQVEIRIETVSSLPMVRSVYGPTSVNKRKLMGLGNLQETKDTVESVKRLNRTTNGVLDLNLPAQETEIEEKYHCEENSNVWLMNLKNHKRLIEVPFKPFDFEGLAEKIKKSVKENFDKCVRSDCLLEVDPKIIERLLAAVYFSDSRKDIKELLENIMSPVFLRIKERYEITTSCVVKLVGRDLDIFLEDQMDLFFVKSQ
Protein: IQ motif containing GTPase activating protein 1 (A4QPB0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELVTLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
Protein: Sidestep III (Q0KIB0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Beaten path VII
Sequence:
MDFPAKRTSTMPLTTSYNANIRRSCLALFALFLFAAHISLTSGQIDWDDDDDPVSTVAVEAVLGRTASLPCDIEPEAKDDRVYMVLWFRESAGKPLYSFDVRGRPFEKALYWSDTNSFGPRAYFVTGQQPAKLSVDNIQLDDEGVYRCRVDFQNSPTRNHRINLTVIVPPHQILVYDASGRDVAGAVGPLLEGDNIVLTCEVRGGRPEPTVTWMNGTRTLEAGSGVSMGRHVTVNRLEVAQISRSALNNTYRCQASNTKLVAPVERSIRIEMLLKPTSVNLTNKLKVFASNTQYNLTCIVAGSVPDTEIKWTQNNRPFKRGLLSTSQSNGRVISTLTFYPQPEDDGTMLKCEGSNPRLQNSAIEDSLMMNVIYPPQVTLSLGSTLRPDDIKEGDDVYFECHIKSNPKEHRIMWSHDGQPVTQNVSWGIIISTRSLVLQRVGRIHSGFYACSAANDRGETQSAPVNLRIRYAPVCSSSSITVIGASLEEDVPIPCRVNSDPPEIDFEWTFSTSGEHFEVPSGHYATIQDPTMTTTSDVRRTVVESNETHFESYVETVSELIYTPKGERDYGTLACYGRNAIGKQSDPCVFQVVPAAKPGALRNCTLRPYVVTSASLNSSNQTTMHANQILPTQYGRHESNYPHMEYVRERHNSSGGNNNGTAPAAGRNNVANKNMRGRTSAGQAKSNNKQLTQQQLQRLKKRTSFTPSQTLAAIERQRQRKQLSQQQQQLQQQHHQATATKSGGDNKPDGSPAKSSKQRMRRASRDPQIQQQQQHQQQQQHQLHAATSITSSQRKQAESNLSTSHLGKGSSSSSRSRRSSSSNINSKSNNGKQPAKYFNKRQKNMHKQKHQQKLKQLKGTTNEHNSNIIHHYAALSSSLRRRKRLAANDILATVAAASTSASLSSPPASSAASLAATATAAVEIEQDVSAVDAPAADSGSNNKRSRKSLTILDKQKQQQEQQQLLPPNAPQISNQPVAAISGNNVKETAATSAHGAVAAGVKDKAPSSKEDSTDNDNDSDGDEDDDDDDDDGAEIDAETETNDEEEDEDEGGEAHDDDADLDEDVAQLATDADYLADGPGDLQEYETVEEVDGQAKHVHMLSLEEQLDLESLEDNVEEEDDGEVDDMYNVSDDDFVASVALSTSDTTAATPLQRTTEGPHIREKATQSQTQTDSATEWQLPHFDYSRMEYSFSNGVVTQSLLGGGAVTGAGHDGFAGGGTINFDNYDNIIYSTMELECMPGYDGGLQQQFFLEAYDSKTMKLRLNMSSTYMDVPVFRIDLSDLMPMDYYPDAHPALHLVVYSVNQKGRSEPIVLENVPINEADKRSDGRMGLSILPLAALLAGTLFTVGIAVLSVVVIAVRRRRGQGARNMCDDKDKHLGMDVTVTAPLETGAGHQRLVVAYTLKQGIEKQPDILSAQKSAPTGGDASSPLGNRPSGLFAGGGGGGGGGGGAAGLASAAPMTGNTGGHKTTDYDGNAPHLNSPPSQSSTLKLESDPAAGGGGLVGARSGGSNPPLLYDAMPTLSRYEQLGLSMASYSAGAGTGGSSSTLSSAGSTVSNAMAANGSAGPGGYAAHLHHTLPHNMAPQRGHDPLNLADYLTTSSLIDYGLNKPPAAHMTLPKGMGLGLGMGLGVGVGAGMGVGPGPGMGMGMASTMAGTSLSPSQLNTITHKSAAGRNHIITDTLPGPESCV
Protein: Cartilage intermediate layer protein 1 (CILP-1) (Cartilage intermediate-layer protein) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2] (O75339)
Organism: Homo sapiens (Human)
Function: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15864306}.
Interaction partners:
- Asporin
- HLA class II histocompatibility antigen, DRB1 beta chain
- Collagen alpha-3
- HLA class II histocompatibility antigen, DR alpha chain
- Collagen alpha-2
- Collagen alpha-1
Sequence:
MVGTKAWVFSFLVLEVTSVLGRQTMLTQSVRRVQPGKKNPSIFAKPADTLESPGEWTTWFNIDYPGGKGDYERLDAIRFYYGDRVCARPLRLEARTTDWTPAGSTGQVVHGSPREGFWCLNREQRPGQNCSNYTVRFLCPPGSLRRDTERIWSPWSPWSKCSAACGQTGVQTRTRICLAEMVSLCSEASEEGQHCMGQDCTACDLTCPMGQVNADCDACMCQDFMLHGAVSLPGGAPASGAAIYLLTKTPKLLTQTDSDGRFRIPGLCPDGKSILKITKVKFAPIVLTMPKTSLKAATIKAEFVRAETPYMVMNPETKARRAGQSVSLCCKATGKPRPDKYFWYHNDTLLDPSLYKHESKLVLRKLQQHQAGEYFCKAQSDAGAVKSKVAQLIVIASDETPCNPVPESYLIRLPHDCFQNATNSFYYDVGRCPVKTCAGQQDNGIRCRDAVQNCCGISKTEEREIQCSGYTLPTKVAKECSCQRCTETRSIVRGRVSAADNGEPMRFGHVYMGNSRVSMTGYKGTFTLHVPQDTERLVLTFVDRLQKFVNTTKVLPFNKKGSAVFHEIKMLRRKKPITLEAMETNIIPLGEVVGEDPMAELEIPSRSFYRQNGEPYIGKVKASVTFLDPRNISTATAAQTDLNFINDEGDTFPLRTYGMFSVDFRDEVTSEPLNAGKVKVHLDSTQVKMPEHISTVKLWSLNPDTGLWEEEGDFKFENQRRNKREDRTFLVGNLEIRERRLFNLDVPESRRCFVKVRAYRSERFLPSEQIQGVVISVINLEPRTGFLSNPRAWGRFDSVITGPNGACVPAFCDDQSPDAYSAYVLASLAGEELQAVESSPKFNPNAIGVPQPYLNKLNYRRTDHEDPRVKKTAFQISMAKPRPNSAEESNGPIYAFENLRACEEAPPSAAHFRFYQIEGDRYDYNTVPFNEDDPMSWTEDYLAWWPKPMEFRACYIKVKIVGPLEVNVRSRNMGGTHRQTVGKLYGIRDVRSTRDRDQPNVSAACLEFKCSGMLYDQDRVDRTLVKVIPQGSCRRASVNPMLHEYLVNHLPLAVNNDTSEYTMLAPLDPLGHNYGIYTVTDQDPRTAKEIALGRCFDGTSDGSSRIMKSNVGVALTFNCVERQVGRQSAFQYLQSTPAQSPAAGTVQGRVPSRRQQRASRGGQRQGGVVASLRFPRVAQQPLIN
Protein: NADPH-dependent FMN reductase-like domain-containing protein (Q9I1J5)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- ArsC protein
- ArsR protein
- Arsenical pump membrane protein
- NAD
- NAD
- Probable NAD
- Probable NAD
- Arsenate reductase
Sequence:
MSEQLPNLDPALLGDPPPVSGHRPRILLLYGSTRERSFSRLLVLEAARLLERFGAETRIFDPSGLPLPDDAPVEHPKVRELRDLVQWSEGQVWCSPERHGALSAVFKAQIDWIPLALGAVRPTQGKTLALMQVCGGSQSFNVVNQLRVLGRWMRMFTIPNQSSVPKAYLEFDEAGRMKPSPYYDRVVDVMEELFKFTLLLRERTDFLVDRYSERKESAEQLSARVDQRSL