wanglab/gogpt-training-data huggingface dataset:
Protein: Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) (O00560)
Organism: Homo sapiens (Human)
Function: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Subcellular location: Cell junction, focal adhesion {ECO:0000269|PubMed:11179419}. Cell junction, adherens junction {ECO:0000269|PubMed:11179419}. Cell membrane {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:27386966}; Peripheral membrane protein {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:27386966}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:11179419}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cytoplasm, cytosol {ECO:0000269|PubMed:11179419}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11179419}. Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Membrane raft {ECO:0000269|PubMed:25893292}. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966). {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:27386966}.
Interaction partners:
- Programmed cell death 6-interacting protein
- Syndecan-1
- CD63 antigen
- Syndecan-4
- Syndecan-2
- Neurofascin
- Interleukin-5 receptor subunit alpha
- Cell adhesion molecule 1
- CD9 antigen
- CD81 antigen
Sequence:
MSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLSLNEEEIRANVAVVSGAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV
Protein: 2-methylacyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.5) (2-methylbutanoyl-CoA dehydrogenase) (2-methylbutyryl-CoA dehydrogenase) (2MBCD) (Isovaleryl-CoA dehydrogenase 1) (St-IVD1) (Q9FS88)
Organism: Solanum tuberosum (Potato)
Function: Short/branched-chain acyl-CoA dehydrogenase (SBCAD). Uses 2-methylbutanoyl-CoA as substrate. Minor activity with the straight-chain substrates, butanoyl-CoA, valeryl-CoA, hexanoyl-CoA, and octanoyl-CoA but no activity with isovaleryl-CoA.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11231285}.
Interaction partners:
- methylcrotonoyl-CoA carboxylase
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Biotin-containing subunit of methylcrotonyl-CoA carboxylase
- Peroxisomal enoyl-CoA hydratase/isomerase family protein
- Electron transfer flavoprotein subunit alpha
- Electron transfer flavoprotein subunit beta
- Isovaleryl-CoA dehydrogenase, mitochondrial
- acetyl-CoA C-acyltransferase
- acetyl-CoA C-acyltransferase
- AMP dependent ligase
Sequence:
MHKLFAVRSLSSAIVKSFKSLQNQQAAFSTSLLLDDTQKQFKESVAKFAQENIAPYAEKIDRTNSFPKEINLWKLMGDFNLHGITAPEEYGGLNLGYLYHCIALEEISRASGAVAVSYGVQSNVCINQLVRNGTPDQKQKYLPKLISGDHIGALAMSEPNAGSDVVSMKCRADRVDGGYVLNGNKMWCTNGPVANTLIVYAKTDTTAGSKGITAFIIEKEMPGFSTAQKLDKLGMRGSDTCELVFENCFVPNENVLGQEGKGVYVLMSGLDLERLVLAAGPVGIMQACMDIVIPYVRQREQFGRPIGEFQLIQGKLADMYTALQSSRSYVYAVAKDCDNGKIDPKDCSGTILLAAERATQVALQAIQCLGGNGYINEYPTGRLLRDAKMYEIAAGTSEIRRLVIGRELFKHQ
Protein: Voltage-gated potassium channel subunit beta-3 (EC 1.1.1.-) (K(+) channel subunit beta-3) (Kv-beta-3) (P97382)
Organism: Mus musculus (Mouse)
Function: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv2.2 but not Kv2.1.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Potassium voltage-gated channel subfamily A member 1
- Potassium voltage-gated channel subfamily A member 2
- Potassium voltage-gated channel subfamily A member 4
- Potassium voltage-gated channel subfamily A member 5
- Voltage-gated potassium channel KCNC1
- Voltage-gated potassium channel regulatory subunit KCNF1
- Potassium voltage-gated channel subfamily A member 3
- Voltage-gated potassium channel regulatory subunit KCNG1
- Potassium voltage-gated channel subfamily A member 7
- Voltage-gated potassium channel KCNC3
Sequence:
MSRGYGLIFSLKVVFTFLSLPHPPGLQGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGLALYWGTSRWSAAEIMEAYSMARQFNLIPPVCEQAENHFFQREKVEMQLPELYHKIGVGSVTWSPLACGLITSKYDGRVPDTCKATVKGYQWLKEKVQSEEGKKQQARVMDLLPTARQLGCTVGQLAIAWCLRSEGVSSVLLGVSSAEQLMEHLGSLQVLSQLTPQTVVEIDALLGNKSHSKK
Protein: ATP-dependent RNA helicase cgh-1 (EC 3.6.4.13) (Conserved germline helicase 1) (Q95YF3)
Organism: Caenorhabditis elegans
Function: Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11546739}. Note=Cytoplasmic when associated with pgl-1. Associates with P granules and this localization is dependent on ifet-1. {ECO:0000269|PubMed:11546739, ECO:0000269|PubMed:23264733}.
Interaction partners:
- Translational repressor ifet-1
- Protein LSM14 homolog car-1
- Protein PAT1 homolog 1
- U6 snRNA-associated Sm-like protein LSm1
- m7GpppN-mRNA hydrolase dcap-2
- mRNA-decapping enzyme 1
- U6 snRNA-associated Sm-like protein LSm7
- CCR4-NOT transcription complex subunit let-711
- Polyadenylate-binding protein
- CCR4-NOT transcription complex subunit 7
Sequence:
MSGAEQQQIVPANNGDENWKAGLNLPAKDRRFKTADVTDTKGVEFEDFCLGRDLLMGIFEKGWEKPSPIQEASIGVALTGQDILARAKNGTGKTGAYCIPVIEKIQPALKAIQAMVIVPTRELALQTSQICVELSKHIQLKVMVTTGGTDLRDDIMRLNGTVHLVIATPGRILDLMEKGVAKMEHCKTLVLDEADKLLSQDFQGILDRLINFLPKERQVMLYSATFPNTVTSFMQKHMHKPYEINLMEELTLLGVTQYYAFVQEKQKVHCLNTLFRKLQINQSIIFCNSTQRVELLAKKITEIGYSCYYIHSKMAQNHRNRVFHDFRQGNCRNLVCSDLLTRGIDIQAVNVVINFDFPRNAETYLHRIGRSGRFGHLGVAINLITYEDRHTLRRIEQELRTRIEPIPKTVDPKLYVADQQLVDAADETTA
Protein: Calcineurin-like metallo-phosphoesterase superfamily protein (F4HNW0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASLYLNSLLPLPPSHPQKLLEPSSSSLLSTSNGNELALKPIVINGDPPTFVSAPARRIVAGFGFGYALTVGDLHGDLGKARDALQLAGVLSSDGRDQWYLLEFNITHLEVGDILDRGDDEIAILSLLRSLDDQAKANGGAVFQVNGNHETMNVEGDFRYVDARAFDECTDFLDYLEDYAQDWDKAFRNWIFESRQWKEDRRSSQTYWDQWNVVKRQKGVIARSVLLRPGGRLACELSRHGVILRVNNWLFCHGGLLPHHVAYGIERINREVSTWMRSPTNYEDSPQMPFIATRGYDSVVWSRLYSRETSELEDYQIEQVNKILHDTLEAVGAKAMVVGHTPQLSGVNCEYGCGIWRVDVGMSSGVLDSRPEVLEIRGDKARVIRSNRDRLHELQVADYI
Protein: Minor ampullate spidroin (K4MTL7)
Organism: Araneus ventricosus (Orbweaver spider) (Epeira ventricosa)
Interaction partners:
Sequence:
MQLPTRLSFFFLVLFIQGFLSQSQPIWTNPNAAMTMTNNLVQCASRSGVLTADQMDDMGMMADSVNSQMQKMGPNPPQHRLRAMNTAMAAEVAEVVATSPPQSYSAVLNTIGACLRESMMQATGSVDNAFTNEVMQLVKMLSADSANEVSTASASGASYATSTSSAVSSSQATGYSTAAGYGNAAGAGAGAAAAVSGGAGSAGGYGEGAGAGVRSGAGASAGAAGGYGRATGAGAGGAAAAGASGYGGSYGAGAGAGAAGAGGASAYGAGIGGGYGAGAADAYGGGASAGAGAGAGAGVSGGYGRAAGAGAAAAAGANGYGGSYDAGVGAGTAGAGAGAGASGGYGGGAGEGAGAAAAAGAGAGGAGGYGGGAGSGAGAVARAGAGGAGGYGSGIGGGYGSGAGAAAGAGAGGAGAYGGGYGTGAGAGARGADSAGAAAGYGGGVGTGTGSSAGYGRGAGAGAGAGAAAGSGAGAAGGYGGGYGAGAGAGAGAGGATGNRAGDAFAQVFSQNVINSGVITSTTVTKNSAQAAASSMVSTAAKSLGLDENTARSMANAMSSYAAAMAKSFRNSDEFIRNMSYQMGRMLSNAGAINESTASAAASSASSTVTETVRTYGPAAIFSGAGAGGAGGYAQGYGAGAGAGAGAGTGAGGAGGYGQGYGAGSGAGAGGAGGYGAGAGAGAGAGGASGYGQGYGDGAGAGAGAAAAAGAAAGARGAGGYGGGAGDGAGAGAGAGAAGGYGQGYGAGEGAGAGAGAGGAGGYGAGAGAGGAGGYGQSYGDGAAAAAGSGAGAGGSGGYGAGAGAGAGAGAGSGAGAAGGYGGGAGAGVGAGGAGGYDQGYGAGAGAGSGAGAGGAGGYGGGAGAGADAGAGGAGGYGGGAGAGAGARAGAGGVGGYGQSYGAGAGAGAGVGAGGAGAGGADGYGQGYGAGAGTGAGDAGGYGGGAGAGASAGAGGYGGGAGAGGVGVYGKGYGSGSGAGAAAAAGAGGATGNRAGDAFAQVFSQNVINSGVITSTTVTKNSAQAAASSMVSTAAKSLGLDENTARSMANAMSSYAAAMAKSFRNSDEFIRNMSYQMGRMLSNAGAINESTASAAASSASSTVTETVRTYGPAAIFSGAGAGGAGGYAQGYGAGAGAGAGAGTGAGGAGGYGQGYGAGSGAGAGGAGGYGAGAGAGAGAGDASGYGQGYGDGAGAGAGAAAAAGAAAGARGAGGYGGGAGAGAGAGAGAAGGYGQGYGAGAGEGAGAGAGAGAVAGAGAAAAAGAGAGAGGAEGYGAGAGAGGAGGYGQSYGDGAAAAAGSGAGAGGSGGYGAGAGAGSGAGAAGGYGGGAGAGVGAGGEGGYDQGYGAGAGAGSGGGAGGAGGYGGGAGAGSGGGAGGAGGYGGGAGAGAGAGAGGAGGYGGGAGAGTGARAGAGGVGGYGQSYGAGASAAAGAGVGAGGAGAGGAGGYGQGYGAGAGIGAGDAGGYGGGAGAGASAGAGGYGGGAGAGAGGVGGYGKGYGAGSGAGAAAAAGAGAGSAGGYGRGDGAGAGGASGYGQGYGAGAAAGAAATAGAGASVAGGYGGGAGAAAGAGAGGYGGGYGAVAGSGAGAAAAASSGAGGAAGYGRGYGAGSGAGAGAGTVAAYGGAGGVATSSSSATASGSRIVTSGGYGYGTSAAAGAGVAAGSYAGAVNRLSSAEAASRVSSNIAAIASGGASALPSVISNIYSGVVASGVSSNEALIQALLELLSALVHVLSSASIGNVSSVGVDSTLNVVQDSVGQYVG
Protein: Large ribosomal subunit protein uL14mz (50S ribosomal protein HLP, mitochondrial) (Protein HUELLENLOS PARALOG) (Q93Z17)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to 23S rRNA in mitochondrion.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11752383}.
Interaction partners:
- At1g01640
- At5g09770
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- 50S ribosomal protein L33
- Putative ribosomal protein L6
- Ribosomal protein
- Small ribosomal subunit protein uS9m
- 50S ribosomal protein L20
- Large ribosomal subunit protein bL21m
Sequence:
MAAAFASRLTRGGRSLLGGLNNGGSMNSSNGMMNESILSQQQQRRTFIQMGTVLKVVDNSGAKKVMCIQALKGKKGARLGDTIVASVKEAMPNGKVKKGAVVYGVVVRAAMQRGRVDGSEVRFDDNAVVLVDSKDKNTKTDRQPIGTRVFGPVPHELRKKKHLKILALAQHVA
Protein: Cold shock protein CspA (CSP-A) (7.4 kDa cold shock protein) (CS7.4) (P0A9X9)
Organism: Escherichia coli (strain K12)
Function: Binds to and stimulates the transcription of the CCAAT-containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3'.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:2404279}.
Interaction partners:
- Large ribosomal subunit protein bL25
- Small ribosomal subunit protein bS21
- Ribonuclease E
- Small ribosomal subunit protein uS15
- Elongation factor Tu 1
- Uncharacterized protein YaeQ
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein bL31
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein bS20
Sequence:
MSGKMTGIVKWFNADKGFGFITPDDGSKDVFVHFSAIQNDGYKSLDEGQKVSFTIESGAKGPAAGNVTSL
Protein: Abnormal oocyte (Q9VKM4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- DNA damage-binding protein 1
- Cullin-4A
- DET1- and DDB1-associated protein 1
Sequence:
MAYKKRLQSQNLVHLLQNRESGYTNVGQQPGRMPLLAYERLFYKCITPCLTIDSITIPPIYLRKFTPDGRKLLAFSQDQRSLLIYSYGGSSCAAVGELIRQADVGSGECFSSQDTILKSRIFERLFPTKETLNLCQGDFGLYYLHREFSVFLEEGRYAMLAAMTVVRGALPVDDYVRYPDLFDKVDAFSYVFFLVDLKLGVVTDRLILPNDSIVIAHNHGISVFGSTVMMMSRLHQCVYVYWVNDGKFHQQETIGPRPRDFIEKATTDFDNLDATTVLPITHIKQRVLSFLYRKINDKSGNPTESQKSFYKNFEYIEHMIMERMHLVNNELLMLRYEERPNGTDTMPMATSPRRLYVFYTITGEEVVGVYPEYSVNLLQILLQFNDYMSNDRSLQFGDAPSLPMHFFLRHTFADSNESVSVDRHTALRFNPSVPLSSQSLSSSPYLKFNEFRYDSRYVSPLEQPHRCCNDPIVFLDRATDSIKFRLHATARRHLNPLAPRELCAFIWHPFDPLVLSIQKCMNSYVYHVHLYNHSTIVEK
Protein: Ascaphin-7 (P0CJ31)
Organism: Ascaphus truei (Coastal tailed frog)
Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very week hemolytic activity.
Subcellular location: Secreted.
Interaction partners:
Sequence:
GFKDWIKGAAKKLIKTVASAIANQ
Protein: Coatomer subunit zeta-3 (Zeta-3-coat protein) (Zeta-COP 3) (Q8H1F4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Interaction partners:
- Coatomer subunit epsilon-1
- Coatomer subunit delta
- Coatomer subunit gamma
- Coatomer subunit epsilon-2
- Coatomer subunit beta-2
- Coatomer subunit alpha-2
- Coatomer subunit alpha-1
- Coatomer subunit beta-1
- Coatomer subunit beta'-1
- Coatomer subunit beta'-3
Sequence:
MAGTNDSCPLVKNILLLDSEGKRVAVKYYSDDWATNASKLAFEKYVFSKTSKTNARTEAEITLLESNIVVYKFAQDLHFFVTGGENENELVLSSVLQGFFDAVALLLRNNVEKMEALENLDLIFLCLDEMVDQGMVLETDANVIAGKVAMQSAEASGSLSEQTLTQALATAREHLARSLLT
Protein: Adenylate kinase 7 (AK 7) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 7) (Q9D2H2)
Organism: Mus musculus (Mouse)
Function: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96M32}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q96M32}. Note=Detected along the full length of sperm flagellum, where it colocalizes with alpha-tubulin. {ECO:0000250|UniProtKB:Q96M32}.
Interaction partners:
- Adenylate kinase isoenzyme 1
- Adenylate kinase 8
- Adenylate kinase isoenzyme 5
- Adenylate kinase 4, mitochondrial
- Adenylate kinase 9
- Adenylosuccinate lyase
- Adenosine kinase
- Adenine phosphoribosyltransferase
- Adenylate kinase 2, mitochondrial
- Pyruvate kinase PKLR
Sequence:
MECDAVIYNITENVQQVEEALWAVSALNEEISHFEKRKVFILLSTVMTWARSKPLDPDDNEVPFTEEDYRRRKHHPNFLDHINAEKIVLKFGKNAKKFATYVVASGLQYGAEGGILHTFFKMAWLGEVPALPVFGDGTNCIPAIHVVDLAGVIQNIIDHVPKLHYLVAVDEAVHTLEDLVKCISKNTGPGKIQKVPKENAFLTKDLTQEYLDHLLVNLRMEALFVKENFNIRWVAQTGFVENINSILKEYKQSRGLLPIKICILGPPAVGKSSISEELAKYYKLHHIKMKDVIAEAIAKLEAIVAPKDSVEGEEEGEEEEEEENVDDAQELLDGIKESMEQNAGRLEDQYIIRFVKEKLKSMPCRNQGFILDGFPKTYDQAKDLFNQEEEEEEEEIRGKIFPYDKLITPEFVCGLDASDEFLKERVMNLPESVVAGTHYSQDRFLRSLSHYRDINTDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGKPRNYGLTDEEKAEEEKKAAEERLAKEAAQTAELEHKEAMEMAEKIARWEEWNKRLEEVKREERELLEVQSVPLRNYLMTYVMPTLMQGLNECCKVRPEDPVDFLAEYLFKNNPEMQ
Protein: Putative transferase CAF17, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog) (Q5T440)
Organism: Homo sapiens (Human)
Function: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:22323289, ECO:0000269|PubMed:23462291}.
Interaction partners:
- Iron-sulfur cluster assembly 2 homolog, mitochondrial
- Iron-sulfur cluster assembly 1 homolog, mitochondrial
- NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
- BolA-like protein 3
- Serine hydroxymethyltransferase, mitochondrial
- Glycine dehydrogenase
- Serine hydroxymethyltransferase, cytosolic
- Lipoyl synthase, mitochondrial
- Dihydrofolate reductase
- Dihydrofolate reductase 2, mitochondrial
Sequence:
MATAALLRGATPGRGGPVWRWRLRAAPRCRLAHSSCSPGGDPTAGAAWACFRLDGRTLLRVRGPDAAPFLLGLLTNELPLPSPAAAGAPPAARAGYAHFLNVQGRTLYDVILYGLQEHSEVSGFLLECDSSVQGALQKHLALYRIRRKVTVEPHPELRVWAVLPSSPEACGAASLQERAGAAAILIRDPRTARMGWRLLTQDEGPALVPGGRLGDLWDYHQHRYLQGVPEGVRDLPPGVALPLESNLAFMNGVSFTKGCYIGQELTARTHHMGVIRKRLFPVRFLDPLPTSGITPGATVLTASGQTVGKFRAGQGNVGLALLWSEKIKGPLHIRASEGAQVALAASVPDWWPTVSK
Protein: Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (A6QLP2)
Organism: Bos taurus (Bovine)
Function: May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24472682}. Microsome {ECO:0000250|UniProtKB:Q68FL4}. Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1. {ECO:0000250|UniProtKB:Q68FL4}.
Interaction partners:
- Cystathionine beta-synthase
- Betaine--homocysteine S-methyltransferase 2
- Methionine synthase
- Betaine--homocysteine S-methyltransferase 1
- Adenosylhomocysteinase like 1.
- Adenosylhomocysteinase
- DNA
- Cystathionine gamma-lyase
- Kynurenine--oxoglutarate transaminase 3
- Aminotran_1_2 domain-containing protein.
Sequence:
MSVQVVSAAAAAKVPEVELKDLSPSEAEPQLGLSTAAVSAMAPPAGGGDPEAPAPAAERPPAPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEALVSPDGTVTEAPRTVKKQIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAASYTDSSDDETSPRDKQQKNSKGNSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIILLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY
Protein: Protein OXIDATIVE STRESS 3 LIKE 6 (AtO3L6) (KID-containing protein-like 2) (AtKCL2) (Q945P6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor (By similarity). Promotes slightly the tolerance to cadmium (Cd) and to oxidizing chemicals (e.g. diamide).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
Sequence:
MEVMVGSSFGIGMAAYVRDHRGVSAQDKAVQTALFLADESGRGGSQIGIGLRMSNNNNKSPEESSDSSSSIGESSENEEEEEEDDAVSCQRGTLDSFSSSLEDSLPIKRGLSNHYVGKSKSFGNLMEAASKAKDLEKVENPFNKRRRLVIANKLRRRGRSMSASNFYSWQNPNSMPLLALQEPNEEDHHIHNDDYEDDDGDGDDHRKIMMMMKNKKELMAQTRSCFCLSSLQEEDDGDGDDDEDE
Protein: Uncharacterized protein (Q38BM1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MISRKDTGNSNCPRSGRTIIRSAVMSLPATPAPLLDGNGHTSTVGPTSIKTIATRRRVMYNSPSYAAGDNSGRVKTLYSAHELSAVSLSNGNWKVASGEPPSGWPPLQPDWSIATHSIPSQRTARNKNVERTVSLDPQGQLLKEGGSGTCTDGDVCPPSARLVRQRHAETREKMPAGSTCSIIAQLPLREQNPRSGEERQPQKLVGDGAVGVDGVVQQSTTSEKRKRKKVKCGRKRKSDSEPLATDRSYVTVLEGSQASLFKNSMCACTPSISNGSARNSNFNDEGCAMNSFSSSVQRSASGPVVTEKWARSIIQPQDEYLLYDRRTPGAIKQEDLVRRGQVILLRERIRCGWPNCCSAHRNQLSREKLADVRTQRHSCESTNAVPSDCSTLDVGDRDDTASSRIVQMNERRIIERGTPLLFRRPYRRLFSDDEKVSKRSDICIPANSSSAPSLGIGSDIPKGHGRSDTSIMVSSIYNLNFSNVSRPFGSTSSTVVTDIAASSNDKNKDCNMPSASSGAGSPGKEKIIFSGSCASQPNAQNLSKAKCQGTTSTHSIAQLLDDAVTQNLDNLVGDPFFLFCGDENHERLLLMQEEHEARVSLKRRCSKPPGCSSSSSSTGEKGIEGSAFQSSPRKESTFVGLFPKQLDMGSRSATENEIRAEGAVAAVGNQNGVSSLSNASSGSLTQSWLIGDDEDEKKQGNLSPRSVSISTGNVDERTSEKLQVKGSTIRSTGTADRARGSEKSVHLTSALARRLNNNADDAACFAEKTRLVVRQKSDSGREGKKREEQTNLVTPLDFSVLHDSCRRSPSQAPETNVYAAPQRREKRPPPPAKGHSKSDFTKIQSVPLSSQHAMALSRASSTSPPQVAGEPLRESLNLSDTEIKNGSVYLNNEIEEFLHFVHRQEQEKKRQKETRSANGKRSPLKAINSVVGTRQSDAKRNGSNGKGKLPLPRSDSSEVGEEQVEADDNSPMEEEAHYAQSVVSVLSSFGQMWNTSFHDVREHRKLPLHVRAQLLLFDVVAS
Protein: Uncharacterized TLC domain-containing protein C17A2.02c (O13752)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSSAVTPSDQGLLPRGPIALEEFVKPFCDRFGLTKLPRHMHVILLSALFYQIINILSPVISRHLSTHYAKLSKKTRLNWDAHVVSSVQSIVLICLGYTCLKEVNAFPDKLFGYSVVAGDIYALTAGYFVWDLYITVRYVHITGIGFVIHAIAALFVITFSYRPYLMYYGPTYLSWELSTPFLNIHYFLDKTNRTGSKFQMINGFILIVTFICVRIAWGWFSAYSTAIEILNHINVAPWALSLFYLAANMSLNCLNLFWVSKMIDAIRRRAHGEKKSTPLQVTSEYAKKNI
Protein: AT3g03330/T21P5_25 (NAD(P)-binding Rossmann-fold superfamily protein) (Q8L7U0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- NAD
Sequence:
MLTLLFFSLGALLLIVLLFKFAFADGDFTLISKKHVKREAIQGKVVWITGASRGIGEILAKQFASLDAKLILSARNKAELDRVKSELKGKFAPEDVKVLPLDLASGEESLKHVVEQAVSLFPGAGVDYLVHNAAFERPKSKASDASEETLKTTFDVNVFGTISLTKLVAPHMLKQGGGHFVVISSAAGKVPSPGQAIYSASKHALHGYFHSLRSEFCQKGIKVTVVCPGPIETWNGTGTSTSEDSKSPEKRVSSERCAELTIIAASHNLKEAWISYQPVLLVMYLVQYMPSLGFWLMDKVGGKRVEVAEKKGNTYSWDLLFGKKTKTN
Protein: Nuclear pore complex protein NUP1 (Nuclear pore complex protein NUP136) (Nucleoporin 1) (Nucleoporin 136) (Q9CAF4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Nucleoporin required for nuclear mRNA export. Functions as an adapter and/or regulator molecule in the periphery of the nuclear pore complex (NPC). May interact with importin proteins and mediate active nucleocytoplasmic transport through the NPC. Involved in regulation of nuclear morphology.
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:19843313, ECO:0000269|PubMed:21189294, ECO:0000269|PubMed:25081480}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:21189294}. Cytoplasm, cytosol {ECO:0000269|PubMed:21189294}. Note=Interacts dynamically with the NPC and localizes to the cytosolic pool following nuclear envelope breakdown during mitosis. {ECO:0000269|PubMed:21189294}.
Interaction partners:
- Nuclear pore complex protein NUP205
- Nuclear pore complex protein NUP155
- Nuclear pore complex protein NUP88
- Nuclear pore complex protein NUP160
- Protein SEH1
- Nuclear pore complex protein NUP107
- Nuclear pore complex protein NUP54
- Protein RAE1
- Nuclear pore complex protein NUP85
- Nuclear pore complex protein NUP93A
Sequence:
MASAARGESSNPYGGGLGTGGKFRKPTARRSQKTPYDRPTTSVRNAGLGGGDVRGGGWLSKLVDPAQRLITYSAQRLFGSLSRKRLGSGETPLQSPEQQKQLPERGVNQETKVGHKEDVSNLSMKNGLIRMEDTNASVDPPKDGFTDLEKILQGKTFTRSEVDRLTTLLRSKAADSSTMNEEQRNEVGMVVRHPPSHERDRTHPDNGSMNTLVSTPPGSLRTLDECIASPAQLAKAYMGSRPSEVTPSMLGLRGQAGREDSVFLNRTPFPQKSPTMSLVTKPSGQRPLENGFVTPRSRGRSAVYSMARTPYSRPQSSVKIGSLFQASPSKWEESLPSGSRQGFQSGLKRRSSVLDNDIGSVGPVRRIRQKSNLSSRSLALPVSESPLSVRANGGEKTTHTSKDSAEDIPGSSFNLVPTKSSEMASKILQQLDKLVSTREKSPSKLSPSMLRGPALKSLQNVEAPKFLGNLPEKKANSPDSSYQKQEISRESVSREVLAQSEKTGDAVDGTSKTGSSKDQDMRGKGVYMPLTNSLEEHPPKKRSFRMSAHEDFLELDDDLGAASTPCEVAEKQNAFEVEKSHISMPIGEKPLTPSEAMPSTSYISNGDASQGTSNGSLETERNKFVAFPIEAVQQSNMASEPTSKFIQGTEKSSISSGKPTSEEKRIPLEEPKKPAAVFPNISFSPPATGLLNQNSGASADIKLEKTSSTAFGVSEAWAKPTESKKTFSNSASGAESSTSAAPTLNGSIFSAGANAVTPPPSNGSLTSSPSFPPSISNIPSDNSVGDMPSTVQSFAATHNSSSIFGKLPTSNDSNSQSTSASPLSSTSPFKFGQPAAPFSAPAVSESSGQISKETEVKNATFGNTSTFKFGGMASADQSTGIVFGAKSAENKSRPGFVFGSSSVVGGSTLNPSTAAASAPESSGSLIFGVTSSSTPGTETSKISASSAATNTGNSVFGTSSFAFTSSGSSMVGGVSASTGSSVFGFNAVSSASATSSQSQASNLFGAGNAQTGNTGSGTTTSTQSIPFQFGSSPSAPSFGLSGNSSLASNSSPFGFSKSEPAVFTSVSTPQLSSTNSSASSSSTMSSPLFGTSWQAPNSSPNSGPVFSSSFTTSSTPTTFSFGGSSAATVSSTTTPIFGASTNNTPSPSPIFGFGSTPPTTPQQPVFGNSGTPSQSLFGNSTPGFAFGAPNNGNGINNNQQVSMEDSMAEDTDQANRASMVAPMFGQAAVSMPQPNFAFGGGAATQPPSMANPFQFGGQPMASTLQNASPFQASQSLEFQGGGSFSLGSTGGGDKSGRRIFKAKKSTRKK