wanglab/gogpt-training-data huggingface dataset:
Protein: Monopolin complex subunit CSM1 (Chromosome segregation in meiosis protein 1) (P25651)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Also plays a mitotic role in DNA replication.
Subcellular location: Nucleus, nucleolus. Chromosome, centromere. Note=Transiently released from the nucleolus and localizes to the centromere regions during late pachytene.
Interaction partners:
- Monopolin complex subunit LRS4
- Monopolin complex subunit MAM1
- Protein DSE3
- Casein kinase I homolog HRR25
- Kinetochore-associated protein DSN1
- Topoisomerase 1-associated factor 2
- Ubiquitin-like-specific protease 2
- Inner nuclear membrane protein SRC1
- Nuclear rim protein 1
- Tyrosine-protein phosphatase CDC14
Sequence:
MDPLTVYKNSVKQQIDSADLLVANLVNENFVLSEKLDTKATEIKQLQKQIDSLNAQVKELKTQTSQQAENSEVIKDLYEYLCNVRVHKSYEDDSGLWFDISQGTHSGGSSDDYSIMDYKLGFVKGQAQVTEVIYAPVLKQRSTEELYSLQSKLPEYLFETLSFPLSSLNQFYNKIAKSLNKKREKKDETE
Protein: Guanine nucleotide-binding protein subunit gamma (Q53Y01)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU004973}; Lipid-anchor {ECO:0000256|RuleBase:RU004973}; Cytoplasmic side {ECO:0000256|RuleBase:RU004973}.
Interaction partners:
Sequence:
MPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYIEERSGEDPLVKGIPEDKNPFKEKGSCVIS
Protein: Grunge, isoform D (Grunge, isoform E) (Q7KUA8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAASTQGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESRWSPGVVADGDLLMFLRAARSMAAFQGMCDGGLEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKCPVSKGIDKKWTEDETKKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQSALRRNRVTRANNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSPAVSKEENSSLTEDDASECDSDSSLTHKRDESPSRMRTRNKQQNNNSSTSSGNNTAGNGGGNATSISSGSTGGGAAGGNSSSKDQSANAVANGKRPKRGSETPDVSGGASVDSPKTPTKAVAESSANKRKGGKQDTPNKKKRTEQESNEPSAHEENAIKEKRKRPDSPVESMNSDSRPDSVLDDGESNTTDTTTAEQQSTKDSKETVSCKEEREMVTNDLEAKAEEKAIKAEALAEDSKDSAIKNMDEETNIQAPSSADTSLVDGPNPNALPSPVAAPITMKVPTIATVEALNASVDRKEAIEKMESCDSDPEMLKKLATIKQEVSPQQQQHMQQQSQQQMQQQLAPVGIPQPPSCPPSESVYIKKEPMEDSMDATCNQNSNEPQDLKVKIEIKNEDALKHSAGGLPPSGPCAPPSALHPLSGAPVESGQEPLHLQHMPHGQVTTQPPPGYLIDGQLKYGPSGQGVPPQPPQLHSDAAGGVSGAPPGAPTTPQKYPPEMEMKFAPQDLKYPPPPPLDALKYSQEMQAAAAAAAAAGKYDMKYMMEQQGKYNVELSAAHQPPSKPGYQDSLKIPDIKPGFGHLPHNVGSPLDAAHKYGPPPTSQESQQQQPQPPAHQVPPGATPPPGIAMPKPHYQHDVQTPPLGRPFEPTGLMLKYGDPLAAKYGPPQDLKYPMPPVSQAGPADVKPYGGENLIKSSPYGPPPESPIDASARSTPGQDSQGSNSNSQPPSMPPQPQQFQSPHPSPHMPSPAGGGLPPGMHPQNLIHGPPPGAAGGSGPQPPPPPTSLHQPTPTSAGPPSLQHGLHPGHQHSQLSVASSIPPSSIGIPPTLSTMAPSHMHPHLHPHAHLQGLHRPHDLPPSMHPHAPMPLSLQGHPQHGHGLPPSHTSQQQQQQQQQQQPGGPAGTVRTPSPAQQPPRSMHDPQSSREPPTSQPSTTMAGSSGPGGPPPQQSPHAHRTSPLPGLAGSGPPPPGLIGHPMAIHPHLAHLPPGHPAHAALAHPGHHLLSHSIAGLGPGGGPIALLAGPGGLGGIPESALSRRTPPSHLPHSHASSAPLTAHSVASMTSTSMSLTTSTVPSSAFSRASPSVQISSSGGGPSGPGSVGPGGMPNSSAAAAAAAAAHRAASPASSVSSLSRQSPLHPVPQSPLSHHPSSSALSAAAAAVAERDRHALMRQQSPHMTPPPVSNASLMASPLSKMYAPQPGQRGLGTSPPPHLRPGASPPVIRHPQMPLPLPLIAPGGGIPQIGVHPGQSPYPHPLLHPSVFYSPHHHPFNSPYGYAPYGPGFPAYMKPPPQPGQLDPAAVMAAHHAGLQGPPPQQMRQDEQNAAAAAAQAAAEKQHQAAAAAAAQQHKAPQQQQPGGMPPNKPPTPKTPQGPGGGMPPGMGGPGTPTGLPPGAYPGSHMPGYPQGPPHGSPFAPQDGQPHGLKPTSHMDALRAHAHSANSAGMGGGHHPTEPLPIDIEPDPEPEIPSPTHNIPRGPSPEAKPDDTECHRSQSAIFVRHIDRGDYNSCTRTDLIFKPVADSKLARKREERDRKLAEKERERRQQQQQQQQQQQQQQAAAAQQAAQQAKMKAELKPPYADTPALRQLSEYARPHVAFSPVEQMVPYHHPMGPMYRERELEEIKNAQAAAASQSRLDPHWMEYYRRGIHPSQFPLYANPAISQMERERLGIPPPHHVGLDPGEHMPQPPEAGFQLPPNVGQYPRPNMLIPREPHSDVLLRMSYADQLQYLQAAEFQRQSLHDQYFRQRPR
Protein: Transcription factor SOX (Q9DG48)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR038098}.
Interaction partners:
Sequence:
MVQQTNNTENTEAALAAGERSQSGAGIELDMASSPTPGATASTGGKADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKQLKDGDKIPFIREAERLRLKHMADYPDYKYRPRKKVKSGGSKPGDKTCGSPSSSSSSPMGSLGSGKPPVKKSSGTKLCNKPHSKLALSARAFPEPDHHSLYKSRAASVRQEKKPKHRVYIFGGSAGYQGSVAVPASPTLSSSSAEASDPLSLYEDGSGSAQNSPGSPSEHDGYTRASSPAPSTSHSSSSAASSPSSASSSSSSSDEELEDELLELNPSPGFENMSLGSFSSAALDRDLDFNFEPGSGSHFEFPDYCTPEVSEMISGDWLESSISNLVFTY
Protein: GH06573p (Q7K3X3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFKMDSADFWQQARAPFGLQTALHQYSSPPNQQPISHHALHHSVPQENEQLAGVQPEGPAAGSGVVGNNSSMAISGTNSTVGSKAESSHIPQQHSEQQSYGSDSFRGTQSPQLSSHHLLFNAAAAAAAAVHLKSTAMQNNLSPIGDQVQNNLRNYGQGSLNALCGIKPKQEMDAKTPLQPLDECPHPLVQAQAQSQYGGDYYDVADPQAREISEGRALIIGLGAPSTVSTDDAQSSAPSHQLAGTGRALQTHQCKPMSPGTVGSSNLGAGRRSAPTTISKTFSQGQQSPQHSTTPSGGSTTPDIKYNNDKMANEIQLQLSRSSSAAAISERTLEECWSTLQRLFMHKSAMQQIQQQIPRVGLGTHGVTGSANLGGSITPSSDTKPHQCQQCMKSFSSNHQLVQHIRVHTGEKPYKCSYCDRRFKQLSHVQQHTRLHTGERPYKCHLPDCGRAFIQLSNLQQHLRNHDAQVERAKNRPFHCNICGKGFATESSLRTHTSKELQLHLGVLQQHAALIGGPNATSCPVCHKLFLGTEALVDHMKHVHKEKSPPPGGSASSQFSELNQIVTGNGNGTGSSNEQIATQCTTESNSHQATVGSSLIDSFLGKRRTANHPCPVCGKHYVNEGSLRKHLACHAENSQLTNSLRMWPCSVCQAVFTHENGLLTHMESMRMDPKHQFAAQYVLSRAAAEQRERESLLAVTLAASSGASTRIGIADAGNVLPTGAHNSDGSNSKCPSPSANSECSSNGRLSSSTTSDQDQDIDHGLSENENSNQNNIGSSTNNNNNCTSNNNASSHKMAELRLPGTGQYTMDAELHVANRMSLMAAAAAAVAASRPQDGVDTSAVPSAAVQAAVVNLAAAMRMNNSSNGATPYQQHHADHTQAHQTHILQHAHPHHHQQQQAPQHQQQQLSHLLVHTHPSNSNSRSQSSPNINVPSLQNESTAASIAMNMNVHMMRGSLDPDPSLGGMHGIEVLHQHQQQHHHHHHHHTSNYPQHAVTPTNQHTHPHPQTHQTAHHHTSPETALRMHQAEAILRSHTEAAFRLATGSGPDTGVKCEADQNQLNSNNAGNAGGNSGGNSQQHRFHASSNHQENQRPSDS
Protein: Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1) (P13288)
Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Function: Plays many key roles by phosphorylating several proteins including the viral DNA processivity factor BMRF1, EBNA1 or EBNA2. Modifies the host nuclear envelope structure and induces the redistribution of nuclear envelope-associated proteins by phosphorylating host nucleoporins. Subsequently, promotes the nuclear transport of EBV lytic proteins. Required for efficient lytic DNA replication and release of nucleocapsids from the nucleus. Contributes to the compaction of host cell chromatin in cells undergoing lytic replication, presumably by phosphorylating the host condensin complex and host TOP2A. Induces disassembly of the nuclear lamina by phosphorylating with host LMNA. Phosphorylates substrates involved in capsid assembly and DNA packaging. Facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function. Phosphorylates the viral immediate-early protein BZLF1 and inhibits its sumoylation by interacting with host SUMO1 and SUMO2. Phosphorylates also host SAMHD1 and thereby counteracts its antiviral effect by reducing its dNTP hydrolase activity.
Subcellular location: Virion tegument. Host nucleus {ECO:0000269|PubMed:22398289, ECO:0000269|PubMed:22623767}. Note=the protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs.
Interaction partners:
Sequence:
MDVNMAAELSPTNSSSSGELSVSPEPPRETQAFLGKVTVIDYFTFQHKHLKVTNIDDMTETLYVKLPENMTRCDHLPITCEYLLGRGSYGAVYAHADNATVKLYDSVTELYHELMVCDMIQIGKATAEDGQDKALVDYLSACTSCHALFMPQFRCSLQDYGHWHDGSIEPLVRGFQGLKDAVYFLNRHCGLFHSDISPSNILVDFTDTMWGMGRLVLTDYGTASLHDRNKMLDVRLKSSKGRQLYRLYCQREPFSIAKDTYKPLCLLSKCYILRGAGHIPDPSACGPVGAQTALRLDLQSLGYSLLYGIMHLADSTHKIPYPNPDMGFDRSDPLYFLQFAAPKVVLLEVLSQMWNLNLDMGLTSCGESPCVDVTAEHMSQFLQWCRSLKKRFKESYFFNCRPRFEHPHLPGLVAELLADDFFGPDGRRG
Protein: Probable conserved membrane protein (O06298)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible transcriptional regulatory protein
- Uncharacterized protein
- Uncharacterized protein Rv0104
- L-asparagine permease 2
Sequence:
MPGARELTLRVERGALFRRRWAASAASSARAAIRRDPRRCALGTRPRWVSFLVIVLVIMNVVTAHPKYPNDPLALVLIELRHPRTEPPVPSAISILKEELARWTPILEQEEVRQVNLETGEHTAHSQKKLVARDRRTAITFRPDAMTLEVTDYPGWEEFRSIVHAMVTARQDVAPVDGCIRIGLRYINEIRASLAEPSGWAYWVAESLLGPGTQLADLKLTTTAQRHVIQCEGPEPGDSLTLRYAGARGAVIQSTPFLQRLKEPPAEGDFFLIDIDSAWSDPCKGIPALDAHLVDEVAERLHTPIGPLFESLITSELRTKVLQQPGQE
Protein: Polyol phosphate phosphatase PYP1 (EC 3.1.3.50) (P53981)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Hydrolyzes sugar alcohol (polyol) phosphates. Dephosphorylates a variety of substrates, including: sn-glycerol 1-phosphate (D-glycerol 3-phosphate), D-ribitol 5-phosphate, D-sorbitol 6-phosphate (D-glucitol 6-phosphate), and D-erythrose 4-phosphate. Prevents accumulation of toxic levels of polyol phosphates, which can impair glycolysis by inhibiting glucose-6-phosphate isomerase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Acireductone dioxygenase-requiring))
- Methylthioribulose-1-phosphate dehydratase
- Methylthioribose-1-phosphate isomerase
- Phosphatase DCR2
- Enolase-phosphatase E1
- Phosphoserine aminotransferase
Sequence:
MVKAVIFTDFDGTVTLEDSNDYLTDTLGFGKEKRLKVFEGVLDDTKSFRQGFMEMLESIHTPFPECIKILEKKIRLDPGFKDTFEWAQENDVPVIVVSSGMKPIIKVLLTRLVGQESIHKIDIVSNEVEIDAHDQWKIIYKDESPFGHDKSRSIDAYKKKFESTLKAGEQRPVYFYCGDGVSDLSAAKECDLLFAKRGKDLVTYCKKQNVPFHEFDTFKDILASMKQVLAGEKTVAELMEN
Protein: Cytochrome P450, family 705, subfamily A, polypeptide 27 (F4I6I6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Cleavage stimulating factor 64
Sequence:
MAAITVDFQLCFIFILLGIFSLFCLSAFFFKKPKDPQLQGCGLPPSPPSLPVIGHLHLLLSVPCLKSFQKLSSKYGPLLHLRAFNIPIVIVSSGSMANEVLRTQDLNFATRQREVSIMEKSLLFGSFGFVSAPYGDYWRFMKKLLVTNLFGSHSLEQTRLIREKELKTFRTMLFDKAAKKGTVDVGKEMMKLTNNSICRMIMGRRCSEENSEAEKVEDLVIKSFSLVKKVLIANTVGRLLKKFGISLFEKEIMEVSQRYDELLEKIIKEHEEDPNKKEDRDMMDVLLEVCADDKAEVKITRNQIKALIVELFLGGTDTSAQTIQWIMAELINHPEILKILREEIESVVGTTRFIQETDLSNLPYLQAVMKEGQRLHPHSPMLVRNATKGCKIGGYYIPQNTTMLINTYAMMIDPDSWENPDKFQPERFMVSPSKGKDDEREQLALNFIPFGSGRRACPGEKLGYLFTGVAIGTMVQCFDWIIDGDKVNVEEAGEMTLTMAHPLKCTPVTRVNPLASFESEDPKWLMEEFDMYC
Protein: Tyrosine-protein kinase transmembrane receptor Ror2 (dRor2) (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) (Q9V6K3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tyrosine-protein kinase receptor that functions during early stages of neuronal development.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- SP2353, isoform A
Sequence:
MAAGQWVGVVERVLRGMVLKWGANLAVLGLCVFLFASATHANSLNAIEEPVTRRHHQRHHEREREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTGLCREAAEKMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIAESECKAML
Protein: DNA (cytosine-5)-methyltransferase 3 (EC 2.1.1.37) (DNA methyltransferase 3) (DNA methyltransferase III) (Protein MATERNAL EFFECT EMBRYO ARREST 57) (Q9T0I1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Maintains chromatin CpG methylation that plays a role in genomic imprinting, regulation of embryogenesis and seed viability. Required for proper patterns of CG DNA methylation in dividing cells (By similarity). Required during the endosperm development in seeds.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Adenosylhomocysteinase 2
- Adenosylhomocysteinase 1
- E3 ubiquitin-protein ligase ORTHRUS 5
- E3 ubiquitin-protein ligase ORTHRUS 1
- E3 ubiquitin-protein ligase ORTHRUS 3
- E3 ubiquitin-protein ligase ORTHRUS 2
- DNA
- Alpha/beta-Hydrolases superfamily protein
- Transcriptional activator DEMETER
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4
Sequence:
MKTKAGKQKKRSVDSDDDVSRERRPKRATSGTNFKEKSLRFSEKYETVEAKKEQIVGDDEKEEKGVRFQSFGRVENWTISGYEDGSPVIWISTVIADYDCRKPSKKYKKLYDYFFEKACACVEVCKNLSTNPDTSLKELLAAVVRSMNGRKIFSSGGVIQEFVISQGEFIYNQLAGLDETSKNHETKFVDNRVLVSLRDESRKIHKAFSNVALRIDESKVLTSDQLMDGGEDEDLKYAKLLQEEEHMKSMDRSRNKRSSTTSAPNKFYIKINEDEIAHDYPLPSYYKNTKDETDELVLFNAGYAVDARNLPCRTLHNWALYNSDLMLISLEFLPMKPCADIDVTYLGQIKEWKIDFGEDMIFVLLRTDMAWYRLGKPSEQYAPWFEPILKTVRIGTSILALLKNETRMAKLSYTDVIKRLCGLEENDQAYISSTFFDVERYVIVHGQIILQFLTECPDEYIKRCPFVTGLASKMQDRHHTKWIIKKKRKMLQKGENLNLRRGKAPKVSKMKAMQATTTRLINRIWGEFYSIYSPEDPLEEIGAEEEFEEVEDVEEEDENEEEDTIQKAIEVQKADTLKKIRGSCKEMEIRWEGEILGETCAGEPLYGQALVGGRKMDVGGAVILEVDDQGETPLIYFVEYMFESSDNSKKLHGKLLQRGSETVLGTAANERELFLTNECLTVQLKDIKGTVSFEIRSRPWGHQYKKEHMAADKLDRARAEERKAKDLPIEYYCKSLYSPEKGGFFSLPRSDMGLGSGFCSSCKIRENEEERSKTKLNDSKTRFLSNGIKYSVGDFVYQIPNYLSKDRGKRRPVFKYGRNVGLRAFVVCQILDIVDLKEPKKGNTTSFEVKVRRFYRPDDVSAEEAYASDIQEVYYSEDTYILPPEAIKGKCEVMKKTDMPLCREYPILDHVYFCDRFYDSSNGCLKKLPYNMMLKFSTIKDDTLLREKKTETGSAMLLKPDEVPKGKRLATLDIFAGCGGLSYGLEKAGVSDTKWAIEYEEPAAQAFKQNHPKTTVFVDNCNVILRISWLRLLINDRAIMEKCGDVDDCISTTEAAELATKLDENQKSTLPLPGQVDFISGGPPCQGFSRLNRFSDGSWSKNQCQMILAFLSFADYFRPKYFLLENVKTFVSFNEGHTFHLTVASLLEMGYQVRFGLLEAGAYGISQPRKRAFIWAAAPNEVLPEWPEPMHVFNNPGFKIPLSQGLHYAAVQSTKFGAPFRSITVRDAIGDLPPIESGESKINKEEMRGSMTVLTDHICKKMNELNLIRCKKIPKTPGADWRDLPDEHVNLSNGIVKNIVPNLLNKAKDHNGYKGLYGRLDWHGNLPTCITNLQPMGLVGMCFHPDQDRIISVRECARSQGFPDSYKFSGNIKDKHRQVGNAVPPPLAFALGRKLKEALHLRNI
Protein: Glutathione S-transferase U1 (AtGSTU1) (EC 2.5.1.18) (GST class-tau member 1) (Glutathione S-transferase 19) (Q9ZW30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Glutathione S-transferase DHAR2
- Glutathione S-transferase U25
- Glutathione S-transferase DHAR3, chloroplastic
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase F2
- Glutathione S-transferase U7
- Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial
- Glutathione S-transferase U26
- Glutathione S-transferase F7
- Glutathione synthetase, chloroplastic
Sequence:
MAEKEESVKLLGFWASPFSRRVEMALKLKGVPYEYLEEDLPNKTPLLLELNPLHKKVPVLVHNDKILLESHLILEYIDQTWKNSPILPQDPYEKAMARFWAKFIDDQILTLGFRSLVKAEKGREVAIEETRELLMFLEKEVTGKDFFGGKTIGFLDMIAGSMIPFCLARLWKGIGIDMIPEEKFPELNRWIKNLEEVEAVRGCIPPREKQIERMTKIAETIKSA
Protein: Inactive zinc metalloprotease C354.09c (O43023)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable metal homeostasis protein bsd1
- SPRY domain-containing protein C285.10c
- Putative E3 ubiquitin-protein ligase C36B7.05c
- Uncharacterized mitochondrial carrier P23A10.06
- Uracil permease
- Protein urg3
Sequence:
MTDEKHVYVPPPKDPPSYEEVALHSALNNSAPPNDGEQNETSMEEMEIIEPPSEDSSRFPLLRTKLAAIHEGWESACHSFEIRFASTFHRIPFQFLYLAVIATVIILASYYGYFDGVPAWRSVHHYGEDVLLNYIKGCDISDTRQQVMTLSSIPHLAGTVGDSSLLQMIMNRLYYEKGTIVDFREFYAYLNFPQLVSLSIDGDDSFHPSLIESYQVGGYDGVSIPTPATFGGSPSGFVNAPLVYANRGRIEDFEWLVNSGIYVESSIVLVRANQSDFALATANAEKYNASAILIFEDTYLTSLDNLNQVYPAGPYPSANSLYRGSVANHYYYVGDPLTPGWSAHEETNRISPKDANVLPSIVSIPITFNDGIELLKRLQGHGHLVKDSNWCQDLAPVLSEVWTGSKISSPGLEVNVLQDIEDKQKIINIMAQIDGYESDQILVVGAPRDSWCTGASDSSVGTSLLIDVISTFANMAQDLSWKPRRTIVFASWDARQFNAIGSTEFLEYWKESLEAKAVAYINVDVAVSGDTFTARTVPGLKKVIQRAFDVANEEDEMKAANIITDDFDYTSDLTSFLTFAGIPVVNLAFERNEENPTPMPFLGSCEDTVSWIDTFGSEYWENAARLGKIWSYLILFLANDPVVPYDLEDEINGVGEMLKRIPEIPGANALDLRKINEEFSELLESLIRFEDEIREWKSLMMHNSYTVSVKKHPELEGYNAKLARFERSFLDEAGLPGHEWYKHLIYGPNLRNSHSQLFPSIFDALLYGDVEAAQKEVKRIALALDRAHNEIRFA
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q6P954)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAATKSGYEGKIAGLYDLDRTLGKGHFAVVKLARHVFTGQLVAVKVIDKTKLDDLATGHLLQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGGDMYDYILRHEGGVAEDTAKVHFAQIVRAIAYCHRLHVVHRDLKPENVVFFRQQGTVKLTDFGFSNHFKPGTMLMTSCGSLAYSAPEILLGEEYDAPAVDIWSLGVILYMLVCGHPPFQETNDSETLIMIMDCRYTVPNHISAQCKDLISRMLQRDPAKRASLAEIESHPWLQGVDPSPAGFTAAPLTSHRSLLPEEHEFILQAMTSGSIAGRDAIQEALEADRYNHITATYYLLGERLLRDKQEQSSLTPEQRNTQRPISEPLDLVSQVPRTDTLRGTPLSALAPLGSLSTGYVRRGVSESGDLLAPKANRHDNSFSDFCSTAPCLSLNMRPLPPDQPTVKSLGALQQICEEEEEEDEVKVKMAPGKLGPLPSTDLSLKPSRTSLQSEPQMRTGRHSSKGMGNCETLAEEEEELEEGSESIEEHKKPLDLVSSISSGTVEHQVEMPPKTEPQVEEFNHTKQPGKGNDKSVFTHVSLSLEEQEGEEIQGPNVDGPLPAPRLDVVQCCWGQREPSKDILENNNNTLAKSRLLEAGVISTPCGSPRSLPRNHCVDLGPDGVEMRKTVGELEKPEEVQPKSQKVLQGTRGTITDPTIRADPSKVKNVNLRERLMQFPLCEKALSFNIQPTSKEKLLPFAQYNCCHVL
Protein: Fumarate hydratase class II 2 (Fumarase C 2) (EC 4.2.1.2) (Aerobic fumarase 2) (Iron-independent fumarase 2) (Q51404)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00743}.
Interaction partners:
- Superoxide dismutase
- Fumarate hydratase class I
- Tetratricopeptide repeat protein
- FagA protein
- Succinate dehydrogenase flavoprotein subunit
- Probable malate:quinone oxidoreductase 1
- Succinate dehydrogenase iron-sulfur subunit
- Succinate dehydrogenase cytochrome b556 subunit
- Citrate synthase
- NAD-dependent malic enzyme
Sequence:
MTDTRIERDSMGELAVPATALYGAQTQRAVNNFPVSGQRMPQAFVRALLLAKAAAARANVSLQQLDAPMGEAIADTCLQLLQEDFMQHFPVDVFQTGSGTSSNMNANEVVATLASRRLGGKVNPNDHVNCGQSSNDIIPSTIHISAALEISERLLPALRHLEQTIQSKAGEVHAYVKTGRTHLMDAMPVRMSQVLGGWAQQVRQAGVHIESVLPALQQLAQGGTAVGTGINAHPRFAERFSQELNDLTGLAFRPGDDFFALIGSQDTAVAASGQLKTLAVTLMKLANDLRWMNSGPLAGLGEIELEALQPGSSIMPGKVNPVIPEATAMVAAQVIGNDAAIAVAGQSGNFELNVMLPLVADNLLHSIQLLANVSRLLADKAIASFKVNQGKLSEALARNPILVTALNPIIGYQKAAEIAKQAYREGRPIIDVALENTDLDRARLEVLLDPEKLTAGGL
Protein: Calsyntenin-2 (Q9ER65)
Organism: Mus musculus (Mouse)
Function: May modulate calcium-mediated postsynaptic signals.
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:12498782, ECO:0000269|PubMed:24613359}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12498782}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12498782}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:12498782}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000269|PubMed:12498782}.
Interaction partners:
Sequence:
MLPGRLCLVPLLLALGVGSGGGSGDGGDSRRRRLLVAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPREAAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAIVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQVTAELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDGRQGAKIPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGACWQGGEVAKPRFAQFFHGSLASLTIRPGKMESQKVISCLQACKEGLDINSLESLGRGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLRLSSKVQCFGEDVCISIPDVDAYIMVLQAIEPQITLQGTERFWRPAAQFESARGVTLFPDIKIVSTFAKTEASGDMRATGTAPKSAVLEEMLHNLDFCDILVLGGDLDPRQECLELNHSELHQRHLDATNSTAGYSIYGVGSMNRYEQVLHHLRYRNWHPTSLETRRFRIKCSELNGRYTSNEFNLEVSVLHEVRVSDKEHVNHLIVQPPFLQSVHHPETRSSIQRSSVVPSIATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAKEAEMDWDDSALTITVNPMEKHEGPGNGEDETTEVEEEEEAEEGSSSSSSGSDDSEEEEEEGMGRVRHGQSGTSSQSPERSTWNTAGVINIWK
Protein: Neuronal acetylcholine receptor subunit alpha-3 (P32297)
Organism: Homo sapiens (Human)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Synaptic cell membrane {ECO:0000250|UniProtKB:P04757}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:31708116}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P04757}. Golgi apparatus {ECO:0000250|UniProtKB:P04757}. Note=Interaction with UBXN2A/UBXD4 promotes translocation to the plasma membrane. {ECO:0000250|UniProtKB:P04757}.
Interaction partners:
- Neuronal acetylcholine receptor subunit beta-4
- Neuronal acetylcholine receptor subunit alpha-5
- Neuronal acetylcholine receptor subunit beta-2
- Neuronal acetylcholine receptor subunit alpha-9
- Proteasome subunit alpha type-4
- Neuronal acetylcholine receptor subunit alpha-7
- Neuronal acetylcholine receptor subunit alpha-2
- Neuronal acetylcholine receptor subunit alpha-4
- Tyrosine-protein kinase JAK2
- Acetylcholine receptor subunit alpha
Sequence:
MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
Protein: Uncharacterized protein Rv2237 (P9WLH1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cobalamin biosynthesis protein CobD
Sequence:
MLLPAANVIMQLAVPGVGYGVLESPVDSGNVYKHPFKRARTTGTYLAVATIGTESDRALIRGAVDVAHRQVRSTASSPVSYNAFDPKLQLWVAACLYRYFVDQHEFLYGPLEDATADAVYQDAKRLGTTLQVPEGMWPPDRVAFDEYWKRSLDGLQIDAPVREHLRGVASVAFLPWPLRAVAGPFNLFATTGFLAPEFRAMMQLEWSQAQQRRFEWLLSVLRLADRLIPHRAWIFVYQLYLWDMRFRARHGRRIV
Protein: MKIAA4245 protein (Q5DTF3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
TAVSEPGSHRDSGQDFSASGSSGYCWMVPYREVLFDELFGGTESRFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFVYNSMNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETISEDQLDPTFKESAMAFASYIFTYAKIKTLREGIKVTGNGLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAASHYSEQMAQRLSLPTDTIQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELLREKNGLFLLKNEEASDKYCQEELDRLSKDLMDNISTFSVPGGHRLYMDMREKIEHDYWQVPRKGVKASEVFQNFLQSQAIIESSILQADTALTAGQKAIAEKHTKKEAAEKEQDLLRQKQKEHQEYMEAQEKRNKENLEQLRRKLEQEREQLIKDHNMMLEKLTKEQKTFREEGYKTQAEELRREIHQLGHNIKEMKQNGDSLVESILRSWFSFISPPSESEKAISSVLSLLRKKDRL
Protein: Transferring glycosyl group transferase (Q8L9Q7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Bifunctional dihydrofolate reductase-thymidylate synthase 2
- Bifunctional dihydrofolate reductase-thymidylate synthase 1
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Aminomethyltransferase, mitochondrial
- Putative transferase At1g60990, chloroplastic
- Methionyl-tRNA formyltransferase, mitochondrial
- Glycine dehydrogenase
- Glycine dehydrogenase
- Phosphoribosylamine--glycine ligase, chloroplastic
- Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic
Sequence:
MVLKPIHSFIVILLLVLSVGDKISAGTEPEKEPVPAVWPEQFHALMLMNKSGSLEIVDLWYDWVNGRNFNIIQKQLGKLTYDLEWNNGTSFYYTLDASKTCRTVHFEVGILRPNWLDGAKYMGQRHVNGFLCNVWEKVEFLWYYEDVVTKRPVQWIFYTGREAHVMTFEVGAVLEDEKWQAPVYCFHNEKKEVQ