wanglab/gogpt-training-data huggingface dataset:
Protein: Arginine ADP-riboxanase OspC3 (EC 4.3.99.-) (P0DV36)
Organism: Escherichia coli
Function: ADP-riboxanase effector that inhibits host cell pyroptosis. Acts by mediating arginine ADP-riboxanation of host CASP4/CASP11, blocking CASP4/CASP11 autoprocessing. This prevents CASP4 activation and ability to recognize and cleave GSDMD, thereby inhibiting LPS-induced pyroptosis (By similarity). ADP-riboxanation takes place in two steps: OspC3 first catalyzes ADP-ribosylation of target Arg, and then initiates a deamination to remove one N-omega group (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:A0A0H2US87}. Host cytoplasm {ECO:0000250|UniProtKB:A0A0H2US87}. Note=Secreted via the type III secretion system (T3SS). {ECO:0000250|UniProtKB:A0A0H2US87}.
Interaction partners:
Sequence:
MKIPEAVNHINVQNNIDLVDGKTNPNKATKALQKNILRVTNSSSSGISEKHLDHCANTVKNFLRKSIAAQSYSKMFSQGTSFKSLNLSIEAPSGARSSFRSLEHLDKVSRHYISEIIQKVHPLSSDERLLLSIIINSNFNFRHQSNSNLSNNILNIKSFDKMQSENIQTHKNTYSEDIKEISNHDFVFFGVEISNHQEKLPLNKTHHTVDFGANAYIIDHDSPYGYMTLTDHFDNAIPPVFYHEHQSFFLDNFKEVVDEVSRYVHGNQGKTDVPIFNTKDMRLGIGLHLIDFIRKSKDQGFREFCYNKNIDPVSLDRIINFVFQLEYHIPRMLSTDNFKKIKLRDISLEDAIKASNYEEINNKVTDKKMAHQALAYSLGNKKADIALYLLSKFNFTKQDVAEMEKMNNNRYCNLYDVEYLLSKDGANYKVLEYFINNGLVDVNKKFQKANSGDTMLDNAMKSKDSKMIDFLLKNGAILGKRFEI
Protein: Probable 26S proteasome regulatory subunit p28 (Proteasome non-ATPase subunit 6) (P50086)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the 19S regulatory complex (RC) and appears to have an overlapping role with RPN14.
Interaction partners:
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit RPN2
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome subunit RPT4
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit RPN14
- 26S proteasome regulatory subunit RPN10
- 26S proteasome regulatory subunit RPN9
Sequence:
MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLNNV
Protein: Adapter protein MecA (Q97Q68)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
Interaction partners:
Sequence:
MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKIDQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEVKEEEQEQAEQEAESKKEPYIYYILSFAKLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLNLQKIG
Protein: Basic 7S globulin (SBg7S) (Bg) [Cleaved into: Basic 7S globulin high kDa subunit; Basic 7S globulin low kDa subunit] (P13917)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Seed storage protein. Has a protein kinase activity. Binds leginsulin.
Interaction partners:
- Albumin-1
- Bowman-Birk type proteinase inhibitor
- Glycinin G5
- Glycinin G4
- Kunitz trypsin inhibitor
Sequence:
MASILHYFLALSLSCSFLFFLSDSVTPTKPINLVVLPVQNDGSTGLHWANLQKRTPLMQVPVLVDLNGNHLWVNCEQQYSSKTYQAPFCHSTQCSRANTHQCLSCPAASRPGCHKNTCGLMSTNPITQQTGLGELGEDVLAIHATQGSTQQLGPLVTVPQFLFSCAPSFLVQKGLPRNTQGVAGLGHAPISLPNQLASHFGLQRQFTTCLSRYPTSKGAIIFGDAPNNMRQFQNQDIFHDLAFTPLTITLQGEYNVRVNSIRINQHSVFPLNKISSTIVGSTSGGTMISTSTPHMVLQQSVYQAFTQVFAQQLPKQAQVKSVAPFGLCFNSNKINAYPSVDLVMDKPNGPVWRISGEDLMVQAQPGVTCLGVMNGGMQPRAEITLGARQLEENLVVFDLARSRVGFSTSSLHSHGVKCADLFNFANA
Protein: Ribulose bisphosphate carboxylase large chain (RuBisCO large subunit) (EC 4.1.1.39) (Q6ENG6)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Methylcrotonoyl-CoA carboxylase subunit alpha
- 4-hydroxyphenylpyruvate dioxygenase
- 2-isopropylmalate synthase
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Malonyl-CoA:ACP transacylase
- Enoyl-CoA hydratase
- Acyl-coenzyme A oxidase
- beta-ketoacyl-[acyl-carrier-protein] synthase III
- Ribulose bisphosphate carboxylase small subunit, chloroplastic
- Uncharacterized protein
Sequence:
MSPQTETKASVGFKAGVKDYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVVGEDNQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPTYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREMTLGFVDLLRDDFIEKDRARGIFFTQDWVSMPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAAANRVALEACVQARNEGRDLAREGNEIIRSACKWSPELAAACEIWKAIKFEFEPVDKLDS
Protein: Protein partner of snf, isoform A (Q9VG78)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSSVFTEAPSARPAAAEADSNLVVVYSKSGISFDERAIGNIMEEKSISTISVVRITSPTPSMVDQEEDERLEELANFMETATDSELDSDNGSQSGGDNASEMDEHDEENHNTGDDNNSDSTETEADAPRTRKRVGRKPKAIKKRKRRKPKERPQIVGLRVEQFYADNTADMVVKNALKLAGVSVYKRTAETDALMEVIRNDHNYTPFTSPEQLKNHKRDEKMAMEMQAQSRKIIMQAPGSVKLINAKKRVQAIPLSPVQVKVQRLPVKPHQVQQAAQLQPKVQLIRKPIHSPLPRQKPEIIANNSVNARLRPTRAPVKVIAPPVQEYIEDDDDAQSSDSAEEENADKAYDSEEMSEESDEFQESDNDRDSDMDFDMRHSNRRNPNKRKRVRKVVRQTPSKPMKPLPPPPTTPQHFPELKKRKEVLEPKAPQIGQIIQMPATKSVPAVFALGRGLPSTSFLKIRPTHQSLPVKRPPLPTTPANSNVRRMPAVQLGRIVNSPQEVKEIIINKNMASPKGVFTNLNTLLGEDNNAATKSSPVPLRHRAVMSPSTPRSSYNQQMSPIVVPVPAQAHTPSKGFMPIGVDTAQSHKLPAQIVIETHQSSSELAAENDKQLDLINSIVQDELLKSTLVEQPVVNADEDIPKLVKMLESTAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQFEAEVVKQVLASTEPGTLDAIVSMPTSIEPVDVPQAHTNLLPNASLTEPAQSMTSLPIACSTPSRSVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGSGPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDASESQEDDDDPNKLWCICRQPHNNRFMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISETLCVVCKRPASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQADTVSKVERINVFERKSGRVITGHMAPSAHQFRKWLQENPSFEVLPSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAKKPPEGPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPNRIAAGKPEPVRIGIRRSLREQLLARIKEAQAAEENSGQPTTQWPTVLEVDQFVKNVELEMFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLPEENVSEASSMADTKQTSLVSEPSTSTLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQHNEGGEQPGSGEREHRSREKQSRERDEIVPSPLPKKRDENDQSPVPKKTAEKKTEASAYNLVDQILESEKTVEQAANLGKPKPSPKPLPTLPSSLKAPEPMDNYSRYLHGLTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRITRVNVWEYIKKLKKSPTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFPLGSGDKLPPALQTAEPVPFYEEAQRPNTLLGIIVRCLSKRPADAVPSTPSVPTPVPALSSKVAKRSRSSISYPAQSSPKRKISTHSTSSKDDEFDIDAIIKAPIAKLQKTAPKVVPQPSVPNDADEPYSPGGSDDELVPSAPQRPNDLERQVNEINKQIAAQQMEIAGLLKVEPTGSASSSNVLAAISIPANLSKILASIKDKTNLPSSADDGDEEYNPEDDITATSSFASKKPRSKGRLAHLSEAELLSMVPDNLAGVIPRSSRTRHQLAQSPLTPTPLPPPPPPPGV
Protein: MADS-box transcription factor 14 (FDRMADS6) (OsMADS14) (Protein AGAMOUS-like 10) (Protein APETALA1-like B) (RMADS211) (Q10CQ1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor. May be involved in the control of flowering time.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- MADS-box transcription factor 1
Sequence:
MGRGKVQLKRIENKINRQVTFSKRRSGLLKKANEISVLCDAEVALIIFSTKGKLYEYATDSCMDKILERYERYSYAEKVLISAESDTQGNWCHEYRKLKAKVETIQKCQKHLMGEDLESLNLKELQQLEQQLENSLKHIRSRKSQLMLESINELQRKEKSLQEENKVLQKELVEKQKVQKQQVQWDQTQPQTSSSSSSFMMREALPTTNISNYPAAAGERIEDVAAGQPQHVRIGLPPWMLSHING
Protein: tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Q80UU1)
Organism: Mus musculus (Mouse)
Function: Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9H8Y5}. Note=Translocates to the mitochondria upon exposure to hydrogen peroxide. {ECO:0000250|UniProtKB:Q9H8Y5}.
Interaction partners:
- Transitional endoplasmic reticulum ATPase
- Ribosome quality control complex subunit NEMF
- ATPase family gene 2 protein homolog A
- Eukaryotic translation initiation factor 6
- E3 ubiquitin-protein ligase listerin
Sequence:
MAKPAGDAAVGSRSGELFLPSVSSSATSPAPSAAPAPASVSLLSLNGEAPLIRGLSLVSQAPGEALAWAPRTSCPGENTSSGGKVSPYSLEISEKLFCSACDQIFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEQQSSTGDLSSISGSDDTDSSSEEDLLPLDEGRAESEKPNRPPGFYPHRVLFKNAQGQFLYAYRCVLGPHQIPPEKAELLLQNLQNGGPRYYVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAHGRASRSAGANLRRYNEAMLYKDVRNLLAGPIWSKALGEAETVLFRAPRSGRSLFFGGQGAPLQRDDPRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDEDPREMVRFHSPETHWKPVREERKKDTEKEKTKVPSDANKPLGQDEEPLKQGSESQEEDGSEVELELVELTLGTLDLREFEVLPKRRRRRKKKERSQEQQCGAHGPLPQQPQDEPFSQPTQEVETPLDTLVYEAKAPGQPELWDTLLAACRAGEVEVLKLQLATGLVDPGVKSLLNAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNLDAYDYNKARVPGPLTQEMEARQATRKKEQKAARRQREQQQRKQREQEEQEQEEQRRFAALSDREKRALAAERRLAAQLGAPSPPVPDSAVASAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRPSS
Protein: H/ACA ribonucleoprotein complex non-core subunit NAF1 (Q3UMQ8)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P53919}. Nucleus {ECO:0000250|UniProtKB:P53919}. Note=Shuttles between the cytoplasm and the nucleus. Absent from the nucleolus (By similarity). {ECO:0000250|UniProtKB:P53919}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit DKC1
- H/ACA ribonucleoprotein complex subunit 3
- H/ACA ribonucleoprotein complex subunit 2
- H/ACA ribonucleoprotein complex subunit 1
- Nucleolar and coiled-body phosphoprotein 1
- Pseudouridylate synthase TRUB1
- Nucleolar protein 58
- U3 small nucleolar RNA-interacting protein 2
- Seminal vesicle secretory protein 3B
- Seminal vesicle secretory protein 3A
Sequence:
MEVVEAAAQLQTLKFGGSGQGSAAPQPPEDRREAPPPGVQPPPPAPSGRPPPPPAPSSDPGGRPPPPPAPNWDAGGRPPPPPAPNSDPPPGGAWVTGRNAAEPPPVLQASDSSDSDSDSETDSDSSSSSSSSSSSSSSCVSFPPVLSDGDEDFQLEKENKNFPLKTKDELLLNELPSVEELTVILPEDIALKPLGKVSSIIEQLVIIESVTNIPPVNEDTVIFKSDRQAAGKIFEIFGPVAHPFYVLRFNSSDHIESKGIKINDTMYFAPSMKDFTQYIFTEKLKQDRGSDASWKNDQEPPPEVLDFSDDEKEKEAKQRKKSQIQGRKKLKSELNESGEDFGEVHENWNAYSSSEHSKGYHHREFSRGFARGRYSRRSHGRPPPQQYYNSDHMASQESLGFTPQRQDNPVMPHYPFPPPMFDMHNFPLPPPPPPPPPPPPSMGWAAPSMASHPVLNLPYSMPPPPLPPPPPPPPPSPGENNSSHFGPYF
Protein: Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3) (Transcription factor LRG-21) (Q60765)
Organism: Mus musculus (Mouse)
Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P18847, ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- Transcription factor Jun
- Protein c-Fos
- Mothers against decapentaplegic homolog 3
- Transcription factor JunD
- DNA damage-inducible transcript 3 protein
- Cyclic AMP-dependent transcription factor ATF-4
- Cellular tumor antigen p53
- Transcription factor JunB
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Histone deacetylase 1
Sequence:
MMLQHPGQVSASEVSATAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVNNRPLEMSVTKSEAAPEEDERKRRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS
Protein: Jacalin-related lectin 15 (Protein JACALIN-TYPE LECTIN REQUIRED FOR POTEXVIRUS RESISTANCE1) (F4I9R6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein RESTRICTED TEV MOVEMENT 1
- Probable RNA-dependent RNA polymerase 5
- Probable RNA-dependent RNA polymerase 4
- RNA-dependent RNA polymerase 1
- Probable RNA-dependent RNA polymerase 3
- RNA-dependent RNA polymerase 2
- RNA-dependent RNA polymerase 6
- Protein RESTRICTED TEV MOVEMENT 3
- Protein RESTRICTED TEV MOVEMENT 2
- Plant basic secretory protein
Sequence:
MSTPSGSNPLPMADKLEAKGRIASIKFDYVKNGQPKAGSTHGVSYHNFTEWFDLNHTCDEHILSVKCYYDDGEIQGLVIKTNIRTSAYMGYNIGTTFTLEVKGKKIVGFHGSFDKNLTSLGAYFAPLSPAK
Protein: Fatty-acid-binding protein 3, chloroplastic (AtFAP3) (Chalcone-flavanone isomerase family protein 3) (Q9C8L2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Fatty-acid-binding protein. Interacts with most fatty acids tested and has maximal relative affinity for C16:0.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:22622584}.
Interaction partners:
- Fatty-acid-binding protein 2
- Fatty-acid-binding protein 1
Sequence:
MDGILAAVPSAVCVSLRISCRNLDNAESIYHFPGKSLNRVSVLQTGNYVSRKGNSLLKNRHCGEISRVIVKSAASSVGNAEDYAEETATSVKFKRSVTLPGCSSPLSLLGTGFREKKFAIIGVKVYAAGYYVNESILSGLSAWTGRSADEIQRDSSLFVSIFQAQAEKSLQIVLVRDVDGKTFWDALDEAISPRIKSPSSEDTTALSTFRGIFQNRPLNKGSVILLTWINTSNMLVSVSSGGLPTNVDATIESGNVTSALFDVFFGDSPVSPTLKSSVANQLAMTLV
Protein: Sp1, isoform F (M9PJG1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Transcription initiation factor TFIID subunit 4
- IP01149p
Sequence:
MLTDMTPTAGQLYGSQIPAMGMNISNIATHLQKPQVNPDHPSLRGTPLAMLAAQCNKLSNKSPPPLADAAVGKGFHPWKKSPNSPAAGSSGSSGGGGGGGGSSAGQHSPCAISAASSSSSSGSSGGQSSRSLSSSASTMVNITASRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMGGAGMHSTMANYASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAAAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKGSSESCSDSEEAANQSGESNGLGGVGSGPQTGGAGGGGGGSSSGNGAGTLAVSGSVTTGAGAGSGTGSSNSNSNSGGSSGSVSGSVSGSGSHPGTPTSLHAHSANGTSSSLLGGGLHLATPHQMVAAGGSPVMLHQQQQQQQHQQQQQQQQQQQHQQQQQQQHQQQQQQHQQQQQQHHQQQQQHHHQQFGQQQHPHAHHLHHHAHHAHHLATGGSPGLDPSSLVDIKPPMVXGSLGPFLFTN
Protein: Phosphatidylinositol phosphate synthase (PIP synthase) (EC 2.7.8.-) (CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase) (P9WPG7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall.
Subcellular location: Cell membrane {ECO:0000269|PubMed:31098408}; Multi-pass membrane protein {ECO:0000269|PubMed:31098408}.
Interaction partners:
- Phosphatidylinositol mannoside acyltransferase
- Probable phosphatidylglycerophosphate synthase
- Putative cardiolipin synthase
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- AP-4-A phosphorylase
- Phosphatidyl-myo-inositol mannosyltransferase
- Phosphatidate cytidylyltransferase
- Threonine--tRNA ligase
- Probable CDP-diacylglycerol pyrophosphatase
- Inositol-3-phosphate synthase
Sequence:
MSKLPFLSRAAFARITTPIARGLLRVGLTPDVVTILGTTASVAGALTLFPMGKLFAGACVVWFFVLFDMLDGAMARERGGGTRFGAVLDATCDRISDGAVFCGLLWWIAFHMRDRPLVIATLICLVTSQVISYIKARAEASGLRGDGGFIERPERLIIVLTGAGVSDFPFVPWPPALSVGMWLLAVASVITCVQRLHTVWTSPGAIDRMAIPGKGDR
Protein: Protocadherin related 15 (A0A8I5ZTI9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSPQFALWKCMPHGILLASLLIVSWGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFAGDNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNYEDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPILVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFLHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYILESAPVGATISESLNLTTPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTPTGITRYLTLLQPVDREEQQTYTFLITAFDGVQESEPVVVNIRVMDANDNTPTFPEISYNVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGSKGDFVINRTTGLVSIAPGVELVVGQTYALTVQASDNAPPAERSTGILSLGKALDRESTDRYILIVTASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTAFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFDVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVRILVLHPGEIPRFTQEEYRPPPVSELAARGTVVGVISAAAINQSIVYSIVAGNEDDKFGINNVTGVIYVNSPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENDHPPVFQKKFYIGGVSEDARMFTSVLRVKATDRDTGNYSAMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYSKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQSAMPAAKPAAPVPAAPPPPPPPPPPGAHLYEELGESAMHNLFLLYHFEQSRGNNPVPEDRSSHRDGMAFSSSTTESHEPAHVEGPLDNQANPARTFSFLPDEDDLSTHNPLYMESIGQRSTNSDLQPGTEFGELFVPRTQVKSQSLRGPREKIQRVWNQSVRFPRRLMWKTPNRPETIDLVEWQITRQRAECEKTRCHPSQQGSSNLMVTTEDARGSEKEGGHRDTLIVQQTEQLKSLSSGSSFSSSWSHFSFSTLPTISRAVELGSEPDVVTSPADCTLELSPPRRPRVLNSLGSKRETPTCASDTETKRNSFEMVPHPPSISAPLPQLPLPQPPIAFTTFPLPLSSPNPPRPQLLTFSLPISTTPASSLPPPPPPSLPPPPRPPAPRLFPLPPSTSVPSTDSISTPAAKCTASVTHARETMSTTQPPASNPPCGAEPHRHPKGILRHVKNLAELEKSVSNMYSHIEKNCPPTELSKLHPFCPAEKTNMKITCDQSQETLVRVVEGIDVQTHSQSTSL
Protein: CARD- and ANK-domain containing inflammasome adapter protein (Q5TYM7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable inflammasome component which mediates inflammasome-dependent resistance to bacterial infection by S.typhimurium through association with activated caspa.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29123523}. Note=In the cytoplasm, forms a ring around specks which are large protein aggregates. {ECO:0000269|PubMed:29123523}.
Interaction partners:
- WD repeat-containing protein 90
- Spi-2 proto-oncogene.
- ArfGAP with GTPase domain, ankyrin repeat and PH domain 3.
- Apoptosis-associated speck-like protein containing a CARD
Sequence:
MGSTSFTNPYAIEVIQMKRSELVSGILNPEDLLDLLIANGVLQPDIRVLVSDLTVREEKNSRMLNILISRGERACRIFFYPCLKRAEPDLYQHMRTYVGGVNEGIRDARRQLIGYLLEKDKQGLVKNSKPERIHPKSTANEPNNEPLNKQILKSESNHHDAILEAISSGDLYLLQELTKELDVNSVLSSNDTLLHHAAEYGKEAIVYFLLRQGAKLDLKDKEGRTALHRAAQRGHTAVAVALAKAGADIHATDQTSKTPLHLAAQNGHEGCVKALVHEEKKSLKNQTTVLHMAAIEDNATLAEVLLRNGALVDAQDGQRKTALHHAVRHGNEKTAAVLLKAGAQVDSRIVDAAFQLNRKSLLSLFLQHVHESMSQTEINAALFKAVQRNLDAVVAALIEHGADVNSCNELGYTPVLLAAELGNGEAFKVLVSKKAKLDERLPNQMSSLHLAVQSGSIQIAQILLHKGIDPNISGPKDQTPLHLSASHNQPAMMALLLRVGAQLNPVTQDGFTPLHLASQNGHTEAVAQLLEAKADVHAKDKQGRTALHWAAEQGEVAIIQSLLAAGAYSNASEREKKTPLHLAAAEGHTKAVSALLAGKAKVGAKDMDGCSPLHYAARNGKERAGSVLLASSKSKNVDDKNVWRRTALHLAAEHGHEALVGILLENKAKINALDNNKDTPLHCACKTGHLGTVQRLINWTNGERANLQATNNVKKNALQVAEAGDTEAHENISTLLKKKMFLVK
Protein: Serine (Or cysteine) peptidase inhibitor, clade A, member 5 (Serpina5 protein) (Q66HL5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRFFPILCLVLFFSHGVASRQRSHSKEKKKSKESSVGAVGTSRSRDFAFRLYRALASEAPGQNVFFSPMSVSMSLGMLSLGSGLKTKAQILEGLGLSLQQGQEDMLHKGFQQLLQQFSQPSDGLQLSLGSALFTDPAVHIRDHFLSAMKTLYMSDMFSTNFGNPESAKKQINDYVAKKTNGKIVDLIKDLDSTHVMVVVNYIFFKAKWQTAFSSTNTHKMDYHVTPKKTIQVPMMNREDIYSYILDQNISCTVVGIPYQGNTFALFILPSEGKMKRVEDGLDERTLRNWLKMFTKRQLDLYLPKFSIEGTYKLEKILPKLGIQDIFTTHADLSGLTDHTNIKLSEMVHKSMVEVDESGTTAAASTGILFTLRSARPSSLKVEFTRPFLVVIMDGTNLYFIGKVIQP
Protein: Histidine kinase 1 (EC 2.7.13.3) (Arabidopsis histidine kinase 1) (AtHK1) (Protein AUTHENTIC HIS-KINASE 1) (Q9SXL4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as an osmosensor histidine kinase that detects water stress and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. Positive regulator of drought and salt stress responses, and abscisic acid (ABA) signaling. Confers drought tolerance, probably by regulating levels of ABA accumulation. Plays a redundant role in regulating plant growth and development. Required for the regulation of desiccation processes during seed formation.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Histidine-containing phosphotransfer protein 3
- Histidine-containing phosphotransfer protein 4
- Histidine-containing phosphotransfer protein 5
- Histidine-containing phosphotransfer protein 2
- Probable glutamate carboxypeptidase AMP1
- Ethylene response sensor 2
- Two-component response regulator ARR22
- Two-component response regulator ARR1
- Pseudo histidine-containing phosphotransfer protein 6
- Homogentisate phytyltransferase 1, chloroplastic
Sequence:
MRGDSFSMSIENLPDSPMGSRKKKMQIRKVFDKMTEWVTPWRSNLESPREMMILRGDVEQDEFQYASSHCLSSYYSVFVVRLAIMVMLAILIGLLTVLTWHFTRIYTKQSLQTLAYGLRYELLQRPVLRMWSVLNTTSELTTAQVKLSEYVIKKYDKPTTQEELVEMYQAMKDVTWALFASAKALNAITINYRNGFVQAFHRDPASSSTFYIFSDLKNYSISGTGPEDVSGWNNKSIHGNMSAIWYQQQLDPVTGENLGKPLKIPPDDLINIAGISQVPDGEASWHVTVSKYMDSPLLSAALPVFDASNKSIVAVVGVTTALYSVGQLMRDLVEVHGGHIYLTSQEGYLLATSTDGPLLKNTSNGPQLMKATDSEEWVIKSGAQWLEKTYGSKRPHVVHAENVKLGDQRYYIDSFYLNLKRLPIVGVVIIPRKFIMGKVDERAFKTLIILISASVCIFFIGCVCILILTNGVSKEMKLRAELIRQLDARRRAEASSNYKSQFLANMSHELRTPMAAVIGLLDILISDDCLSNEQYATVTQIRKCSTALLRLLNNILDLSKVESGKLVLEEAEFDLGRELEGLVDMFSVQCINHNVETVLDLSDDMPALVRGDSARLVQIFANLISNSIKFTTTGHIILRGWCENINSLHDEMSVSVDRRKPWAPMKTKQVQHRNHLQKSCKNANKMVLWFEVDDTGCGIDPSKWDSVFESFEQADPSTTRTHGGTGLGLCIVRNLVNKMGGEIKVVQKNGLGTLMRLYLILSTPDTVDQNIQPDFSKYGLVVMLSMYGSTARMITSKWLRKHGIATVEASDWNELTQIIRDLLETGSRDNSFDSQHNISDPLRAELSNIVEIKNPVFVIVVDIGVLDLTTNIWKEQLNYLDRFSNKAKFAWLLKHDTSNTVKTELRRKGHVMMVNKPLYKAKMIQILEAVIKNRKRGLCNDLRNRGNGSDESHDCLEIDPTQFDTCSSDDSSETSGEKQVDKSVKPSTLHSPVLKNYLIDATTSNDDSTSASMTQKNPEEEDWKDRLYSGIALDGKNQKSLEGIRILLAEDTPVLQRVATIMLEKMGATVTAVWDGQQAVDSLNYKSINAQAPTEEHKSFEEETANKVTTRETSLRNSSPYDLILMDCQMPKMDGYEATKAIRRAEIGTELHIPIVALTAHAMSSDEAKCLEVGMDAYLTKPIDRKLMVSTILSLTKPSAFQTSLSA
Protein: CD209 antigen-like protein A (Dendritic cell-specific ICAM-3-grabbing non-integrin) (DC-SIGN) (CD antigen CD209) (Q91ZX1)
Organism: Mus musculus (Mouse)
Function: Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Intercellular adhesion molecule 2
- Integrin alpha-M
- Lymphocyte-specific protein 1
- Intercellular adhesion molecule 5
- Mucin-1
- Protein delta homolog 1
- Intercellular adhesion molecule 1
- Kinase suppressor of Ras 1
- Toll-like receptor 2
- Toll-like receptor 4
Sequence:
MSDSKEMGKRQLRPLDEELLTSSHTRHSIKGFGFQTNSGFSSFTGCLVHSQVPLALQVLFLAVCSVLLVVILVKVYKIPSSQEENNQMNVYQELTQLKAGVDRLCRSCPWDWTHFQGSCYFFSVAQKSWNDSATACHNVGAQLVVIKSDEEQNFLQQTSKKRGYTWMGLIDMSKESTWYWVDGSPLTLSFMKYWSKGEPNNLGEEDCAEFRDDGWNDTKCTNKKFWICKKLSTSCPSK