causes of Hodgkin's disease
It's not clear what causes Hodgkin's lymphoma. Doctors know that most Hodgkin's lymphoma occurs when an infection-fighting cell called a B cell develops a mutation in its DNA. The mutation tells the cells to divide rapidly and to continue living when a healthy cell would die.eople diagnosed with classical Hodgkin's lymphoma have large, abnormal cells called Reed-Sternberg cells in their lymph nodes. Subtypes of classical Hodgkin's lymphoma include: 1  Nodular sclerosis Hodgkin's lymphoma. 2  Mixed cellularity Hodgkin's lymphoma.