when to take methotrexate what day is best
It remains unclear exactly how methotrexate decreases arthritis activity. 4 - Methotrexate is taken one day a week for arthritis. It is not taken daily like most pills. Methotrexate is available in 2.5 mg tablets. The starting dose for most adults with rheumatoid arthritis is 7.5 to 10 mg (i.e., 3 or 4 pills). The 3 or 4 pills are taken together once a week (i.e., the same day each week). As needed, the dose of methotrexate can be increased to 20 to 25 mg each week.