what is pla2
(140k). Phospholipase A 2 is one of the most intensively studied membrane proteins which hydrolyzes phospholipids at the sn-2 position to form fatty acid and lysophospholipid products. These are small proteins and the 3-D structures are known to high resolution for several species.hospholipase A 2 proteins are of high pharmaceutical concern since they are responsible for the release of arachidonic acid from membranes, and since the subsequent conversion of this fatty acid to leukotrienes and prostaglandins is part of the inflammatory response.