how long does it take ibuprofen to kick in
2 days 18 hours ago. Prostaglandins are substances produced in the brain in response to illness or injury which causes pain and swelling and Ibuprofen helps in blocking this substance. According to experts, it takes 15- 20 min for Ibuprofen to kick in and close to 2 hours to take effect. It also depends on the form of Ibuprofen, like; if you are taking ibuprofen in liquid form it will take lesser time as the body doesnât need to break down the capsule/Tablet.