dna replication is considered slightly altered because
During DNA replication, these repeat regions are often altered because the polymerase can slip as it disassociates and reassociates with the DNA strand (Viguera et al. , 2001). To better understand a polymerase slip, imagine you are reading a page of text that is a repeat of a simple sequence.igure Detail. As mentioned, sickle-cell anemia is the result of a change in a single nucleotide, and it represents just one class of mutations called point mutations. Changes in the DNA sequence can also occur at the level of the chromosome, in which large segments of chromosomes are altered.