What is a disease that is pleiotropic?
Unsourced material may be challenged and removed. (September 2013). Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits, an example being phenylketonuria, which is a human disease that affects multiple systems but is caused by one gene defect.Consequently, a mutation in a pleiotropic gene may have an effect on some or all traits simultaneously.he underlying mechanism is that the gene codes for a product that is, for example, used by various cells, or has a signaling function on various targets. A classic example of pleiotropy is the human disease phenylketonuria (PKU).