which cells are affected in digeorge syndrome
Depending upon location, neural crest cells give rise to most of the peripheral nervous system, as well as various non-neural tissues, like craniofacial bone and cartilage, the thymus and parathyroid glands, and the cardiac outflow tract â in short, all of the tissues that are affected in DiGeorge syndrome.
Immunodeficiency: Therapies include thymus transplantation and adoptive transfer of mature T cells (ATMTC) for individuals with complete DiGeorge syndrome and appropriate prophylaxis measures and monitoring autoimmune complications for incomplete or partial DiGeorge syndrome.
The research group, headed by Dr. Lukas Sommer at the Swiss Federal Institute of Technology, has identified a heretofore unknown role for the TGF cell-to-cell signaling pathway in the pathogenesis of DiGeorge syndrome.