chronotropic effect definition
Chronotropic. Chronotropic effects are those that change the heart rate. Chronotropic drugs may change the heart rate by affecting the nerves controlling the heart, or by changing the rhythm produced by the sinoatrial node. Positive chronotropes increase heart rate; negative chronotropes decrease heart rate. A dromotrope affects atrioventricular node conduction. A positive dromotrope increases AV nodal conduction, and a negative dromotrope decreases AV nodal conduction.