causes of premature menopause
Ovarian dysgenesis is a major cause of premature menopause. Ovarian dysgenesis is seen in 30% of the cases.[3] Sex chromosome anomalies predominate as a cause. The commonest abnormality is 45X0 (Turner's syndrome). Chromosomal abnormalities are reported in 10-20% of cases involving X sex chromosomes.[3]
Defects in the chromosomes can cause premature menopause. For example, women with Turner's syndrome are born without a second X chromosome or without part of the chromosome. The ovaries don't form normally, and early menopause is often the result.