the centromere is a region in which
In prophase of mitosis, specialized regions on centromeres called kinetochores attach chromosomes to spindle fibers. The centromere (centro- + -mere) is the part of a chromosome that links sister chromatids. During mitosis, spindle fibers attach to the centromere via the kinetochore.Centromeres were first defined as genetic loci that direhromosomes.hese are X-shaped chromosomes, with the centromere in the middle so that the two arms of the chromosomes are almost equal. A chromosome is metacentric if its two arms are roughly equal in length. In a normal human karyotype, two chromosomes are considered metacentric: chromosomes 1 and 3.