is buprenorphine a nop partial agonist
ALKS-5461 is a (1:1 ratio) combination of: (1) buprenorphine, a weak partial agonist of the Î¼-opioid receptor (MOR), antagonist/very weak partial agonist of the Îº-opioid receptor (KOR), and, to a lesser extent, antagonist of the Î´-opioid receptor (DOR) and weak partial agonist of the nociceptin receptor (NOP); and (2) samidorphan, a preferential ...