name the two types of cells in the cortical collecting ducts and describe their function
Functional differentiation of cell types of cortical collecting duct. O'Neil RG, Hayhurst RA. Interference-contrast and fluorescent microscopy were used to differentiate between the two cell types--principal cells (PC) and intercalated cells (IC)--of the isolated perfused cortical collecting duct of the rabbit.unctional differentiation of cell types of cortical collecting duct. O'Neil RG, Hayhurst RA. Interference-contrast and fluorescent microscopy were used to differentiate between the two cell types--principal cells (PC) and intercalated cells (IC)--of the isolated perfused cortical collecting duct of the rabbit.
Principal cells are the main Na+ reabsorbing cells and the site of action of aldosterone, K+-sparing diuretics, and spironolactone. Type A and B intercalated cells make up the second cell type in the collecting duct epithelium. Type A intercalated cells mediate acid secretion and bicarbonate reabsorption.he collecting duct cells (CDCs) are highly water permeable and are a key component of the collecting duct, the last site where NaCl and water are reabsorbed in the kidney.