causes of congenital insensitivity to pain
For more information visit https://naturalmedicines.therapeuticresearch.com/. Congenital insensitivity to pain with anhidrosis (CIPA) is caused by a mutation in the human NTRK1 gene, which is also called the TRKA gene. This gene provides instructions for making a protein in the neurotrophic tyrosine kinase receptor (NTKR) family. The NTKR family comprises receptors that are found on the surface of nerve cells. The NTKR receptors respond to nerve growth factor (NGF), which is needed by nerve cells for proper function and survival.