what is depo lupron
+Related Content. Leuprolide acetate (Lupron DepotÂ®) is a type of gonadotropinâreleasing hormone agonist (GnRH agonist) medicine. GnRH agonist medications help to lower pelvic pain caused by endometriosis. Addâback therapy is the addition of a small amount of the hormones estrogen and progesterone or progesterone alone.