what does hypersplenism means
â¢ HYPERSPLENISM (noun). The noun HYPERSPLENISM has 1 sense: 1. enlarged spleen and a decrease in one or more types of blood cells; associated with many disorders. Familiarity information: HYPERSPLENISM used as a noun is very rare. HYPERSPLENISM (noun). The noun HYPERSPLENISM has 1 sense: 1. enlarged spleen and a decrease in one or more types of blood cells; associated with many disorders. Familiarity information: HYPERSPLENISM used as a noun is very rare.