what kind of protein hiv virus target
The human immunodeficiency virus type 1 (HIV-1) RNA genome is encapsulated in a conical capsid core, which is delivered into the target cell cytosol as a result of the virus entry process. The HIV-1 capsid is composed of approximately 1,500 capsid (CA) proteins (11).ffects of CA changes on HIV-1 uncoating in HeLa cells. To gain insight into the infectivity defects caused by the CA changes, we studied the uncoating of the wild-type and mutant viruses by using a previously developed fate-of-capsid assay (51).