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Introduction. Charcot-Marie-Tooth disease (CMT) is a group of inherited conditions that damage the peripheral nerves. It's also known as hereditary motor and sensory neuropathy (HMSN).The peripheral nerves are found outside the main central nervous system (brain and spinal cord).harcot-Marie-Tooth disease (CMT). Charcot-Marie-Tooth disease (CMT) is also known as hereditary motor and sensory neuropathy. An expert explains what the disease is, how it affects the nervous system and the possible causes.