can long term use of prograf increase urine protein level?
2. Increased risk of infection. PROGRAF is a medicine that affects your immune system. Prograf can lower the ability of your immune system to fight infections. Serious infections can happen in people receiving Prograf that can cause death. Call your doctor right away if you have symptoms of an infection such as: 1  fever.2  sweats or chills.3  cough or flu-like symptoms. 4  muscle aches. 5  warm, red, or painful areas on your skin.erious infections can happen in people receiving Prograf that can cause death. Call your doctor right away if you have symptoms of an infection such as: 1  fever. 2  sweats or chills. 3  cough or flu-like symptoms. 4  muscle aches. 5  warm, red, or painful areas on your skin.