which pair of nucleotides are stronger
Strength Edit. Base pairs vary in strength. The GC pair is stronger than AU or GU pairs due to the presence of an additional hydrogen bond and stronger stacking interactions. Additionally, the energy of a base pair can be altered by exchanging the positions of two paired bases.he GC pair is stronger than AU or GU pairs due to the presence of an additional hydrogen bond and stronger stacking interactions. Additionally, the energy of a base pair can be altered by exchanging the positions of two paired bases.