how long to cook chicken breast in oven at 375 degrees
1 Preheat oven to 375 degrees F (190 degrees C). 2  Bake in preheated oven until chicken meat is no longer pink at the bone and the juices run clear, 45 to 60 minutes. 3  An instant-read thermometer inserted in the thickest part of the breast meat should read 165 degrees F (75 degrees C). Preheat oven to 375 degrees F (190 degrees C). 2  Bake in preheated oven until chicken meat is no longer pink at the bone and the juices run clear, 45 to 60 minutes. 3  An instant-read thermometer inserted in the thickest part of the breast meat should read 165 degrees F (75 degrees C).