how long does it take for opiates to work
After 36 hours, you will be able to feel the opiates a little bit, â¦ but you won't be able to get a full-blown opiate high for at least 48 to 72 hours. The amount of time can be shorter, if you are not taking Suboxone regularly.After the surgery I waited 10hrs after my last dose of Dilauded to  take 2mg of Suboxone and i was fine. So after all my rambling to a  long story short, if you are going to need opiates you should stay  off the sub's for at least 48hrs longer if you can.