what is dapt
Biochem/physiol Actions. DAPT is a Î³-secretase inhibitor and indirectly an inhibitor of Notch, a Î³-secretase substrate. Other Î³-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4. As an inhibitor of Î³-secretase, DAPT may be useful in the study of Î²-amyloid (AÎ²) formation.