patho of rheumatoid arthritis
The pathophysiology of rheumatoid arthritis is mediated by an inter-related network of cytokines, proteolytic enzymes and prostanoids. IL-1, TNF-alpha, etc. are proinflammatory cytokines and are the central mediators in the disease.nterleukin (IL)-1 is highly responsible for the signs and symptoms of rheumatoid arthritis. First it mediates inflammation by recruiting neutrophils into the joint, activating macrophages, and stimulating T-and B-cell proliferation and differentiation.