how long does methylprednisolone dosepak stay in system
18 Oct 2016. Medrol Dosepak (methylprednisolone) has a medium half life range of 18 to 36 hours - meaning it takes the body 18 to 36 hours to clear 50% of the drug from your plasma. For a drug to be totally eliminated from your system it takes around 5.5 times the half life. As an estimate then, after taking a single dose of methylprednisolone it should be out of your system after 8 days. (5.5 x 36 hours = 198 hours or just over 8 days) Other factors to consider: 1. How much and how often you have taken the drug. 2. Your metabolic rate â a slower metabolism will increase the time a drug remains in your system. 3.