is tamoxifen metabolized in the liver
Contact with blood proteins â about 98%. Excretion of plasma takes place in two phases, with a finite half-life 19-22 hours, allowing to take the drug once daily. Doxazosin is side effects of tamoxifen extensively metabolized in the liver by demethylation of hydroxylation and, in patients with impaired liver function, as well as the reception drugs that can alter hepatic metabolism, the process can break down the drug biotransformation.
Other drugs, known as prodrugs, are activated by the action of CYP2D6. This enzyme also metabolizes several endogenous substances, such as hydroxytryptamines, neurosteroids, and both m-tyramine and p-tyramine which CYP2D6 metabolizes into dopamine in the brain and liver.