what causes a child to get progeria
HGPS is caused by a mutation in the gene called LMNA (pronounced âlamin-aâ). The LMNA gene produces the lamin A protein which is the structural scaffolding that holds the nucleus of a cell together. The abnormal lamin A protein that causes Progeria is called progerin. Progerin makes the nucleus unstable. That cellular instability leads to the process of premature aging and disease in Progeria. Progeria Cell Nucleus. PRF was the driving force behind finding the gene responsible for Progeria.