cyclophosphamide mechanism of action
Mechanism of action: Cyclophosphamide is an inactive drug. With the help of cytochrome P-450 oxidase system in the liver, the inactive drug is converted into phosphoramide mustard and acrolein which are very active compounds. Phosphoramide mustard has an ability to introduces alkyl radicals into DNA strands with interferes DNA replication by forming DNA cross-linkage. Cross-linked cancer cell DNA is unable to complete normal cell division. Thus, it stops cancer cells from growing, causing them to die.