how does progesterone play a role in a feedback mechanism
During the follicular phase of the cycle, estradiol (E2) plays a key role, while circulating progesterone (at low concentrations) and inhibin B contribute to the control of LH and FSH secretion respectively.n terms of the positive feedback mechanism, E2 is the main component sensitizing the pituitary to GnRH. Activity of a non-steroidal ovarian substance, named gonadotrophin surge-attenuating factor (GnSAF), has been detected after ovarian stimulation. It is ...