what is ursodiol
3 Reviews. Ursodiol is a bile acid that decreases the amount of cholesterol produced by the liver and absorbed by the intestines. Ursodiol helps break down cholesterol that has formed into stones in the gallbladder. Ursodiol also increases bile flow in patients with primary biliary cirrhosis.ou should not use ursodiol if you have an obstruction in your liver or gallbladder. You should not use ursodiol if you are allergic to it, or if you have an obstruction in your liver or gallbladder. To make sure ursodiol is safe for you, tell your doctor if: 1  you have been coughing up blood; or.