immune system lupus
About Lupus. Lupus is an autoimmune disease that can affect various parts of the body, including the skin, joints, heart, lungs, blood, kidneys, and brain. Normally, the body's immune system makes proteins called antibodies to protect the body against viruses, bacteria, and other foreign materials.hese foreign materials are called antigens. In an autoimmune disorder like lupus, the immune system cannot tell the difference between foreign substances and its own cells and tissues. The immune system then makes antibodies directed against itself.