what is the gene encoding for calreticulin
To the Editor: Somatic mutations in the gene encoding calreticulin (CALR) were recently described in the majority of patients with myeloproliferative neoplasms without mutations in the Janus kinase 2 gene (JAK2).n this patient, the CALR mutation was a deletion (p.L367fs*46), which was detected in two samples obtained before interferon alfa therapy and was reduced in two subsequent samples (Figure 1). Both patients reported moderate fatigue and mood changes, which resolved after discontinuation of interferon alfa.