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However, the past few years have seen the approval new prescription weight-loss pills. The new prescription weight-loss drugs include: Qsymia; Contrave; Saxenda; Belviq; The approval came after a requirement that the drugs prove a loss of more than 5 percent of body weight, more than the effectiveness of the placebo. Best Prescription Weight-Loss Drugs. The best prescription weight-loss drug depends on oneâs health situation.