hfpef medical definition
HFpEF vs. HFrEF. June 1, 2015. Ejection fraction is an important measurement in the diagnosis and surveillance of HF. However, it is possible for patients with normal ejection fraction to have HF, and this form of the disease, HF with preserved ejection fraction, or HFpEF, is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. Moreover, women are disproportionately affected by HFpEF, outnumbering men 2:1. In HFpEF, the muscles of the heart contract normally and the heart may seem to pump a normal proportion of the blood that enters it.