what feature of the fat itself makes it hydrophobic
In contrast, the long isoprene or. fatty-acid tails of a phospholipid are nonpolar. Water mole-. cules cannot form hydrogen bonds with the hydrocarbon tail, so they do not interact with this part of the molecule. Compounds that contain both hydrophilic and hydrophobic. elements are amphipathic (âdual-sympathyâ).