what does elevated atypical lymphocytes mean?
Answers. Best Answer: The atypical lymphocyte is a reactive lymphocyte of lymphoid origin that plays an important role in the immune response. An atypical lymphocyte is a nonmalignant white cell (leukocyte) seen in a peripheral blood smear (how a differential is performed).here a lot of infections, medications and auto-immune disorders that trigger atypical lymphocytes. I strongly suggest you speak to the provider who ordered the CBC and get interpretation from that person. I don't know your health history, why the test was ordered or what other tests were ordered and the results.