what is the cause of osteogenesis imperfecta
Back to Top Causes. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene.The severity of OI depends on the specific gene defect.ow well a person does depends on the type of OI they have. 1  Type I, or mild OI, is the most common form. 2  Persons with this type can live a normal lifespan. 3  Type II is a severe form that is usually leads to death in the first year of life. 4  Type III is also called severe OI.