which vitamin requires intrinsic factor in order to be absorbed?
active oldest votes. up vote 2 down vote accepted. Vitamin B12 (cobalamin) is a water-soluble vitamin required for homocysteine methyltransferase. In order to be absorbed, it must bind to intrinsic factor (IF), which is produced by the parietal cells of the stomach. The absorption of the vitamin B12-IF complex occurs in the terminal ileum (of the small intestine).