is zyrtec a anticholinergic drug
Making the world better, one answer at a time. Zyrtec (cetirizine) is classified as a second generation antihistamine. It is believed to antagonize peripheral H1 receptors and not cross the blood brain barrier (this is why it is less drowsy then other antihistamines).The side effects of Zyrtec such as dry mouth may suggest that it does have some anticholinergic properties.owever, despite the claims of minimal muscarinic receptor activity, anticholinergic side effects may still occur with venlafaxine. 14 people found this useful. 1  Allergy Medications: Zyrtec Versus Claritin Zyrtec versus Claritin is more a matter of the side effects of both drugs versus their effects on allergies.