where is the highest pressure in the heart?
Answer by Anatomy James. Confidence votes 5.8K. The Chamber that creates the highest pressure is the Left Ventricle. It must do this to get the blood all the way around the body, including right up to the top of the heat, but more importantly it must overcome the huge pressure in the Aorta. This is because of the Aortic Valve which sits stops the blood being pushy back formthe aorta into the ventrivle.