how long does it take a brisket to cook in the oven
1 Place a fat-trimmed 3- to 3-1/2-pound fresh beef brisket in a 13x9x2-inch baking pan. 2  Pour the cooking liquid over the meat. 3  Cover the pan with foil. 4  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time.