how long does it take to drive from miami to naples
1 Driving from Miami to Naples. 2  Distance: 110 miles. 3  Driving Time: 2 hours, 10 minutes. 4  The west coast of Florida brings you into the lap of luxury. 5  Naples' opulent relaxation is a great way to escape the hustle and bustle of life in Miami, especially during the off-season when crowds are light. Driving from Miami to Key West. 2  Distance: 160 miles. 3  Driving Time: 3 hours, 30 minutes. 4  The slow drive will cause this 160 mile trip to take you up to four hours, but the scenic drive is part of the pleasure of the Keys!