most of the dna in a eukaryotic cell is in the _____.
Most of the DNA in eukaryotes is found in the nucleus, while prokaryotes, lacking a nucleus, have their DNA loose in the cytoplasm. Explanation: In eukaryotes, the genomic DNA, which makes up most of the cells DNA, is contained in the nucleus. There is additional DNA in the cells mitochondria, and still more in the chloroplast if it is a plant cell, but it is a very small amount.