are anthracyclines topoisomerase inhibitors?
Top2 have been used as targets for the development of anticancer drugs. These inhibitors include anthracyclines (doxorubcin, daunorubicin, epirubicin) and epipodophyllotoxins (etoposide), which are widely used in the clinic. These drugs poison Top2 by trapping the enzyme on its DNA cleavage sites, which results in irreversible double-strand breaks that are responsible for cell death.
[Molecular determinants of response to topoisomerase II inhibitors]. [Article in French] Lansiaux A(1), Pourquier P. Author information: (1)Centre Oscar Lambret, UniversitÃ© Lille Nord de France. a-Lansiaux@o-lambret.fr