what are the causes and types of necrosis?
This lack of signalling makes it harder for the immune system to locate and recycle dead cells which have died through necrosis than if the cell had undergone apoptosis. The release of intracellular content after cellular membrane damage is the cause of inflammation in necrosis. There are many causes of necrosis including injury, infection, cancer, infarction, toxins and inflammation. Severe damage to one essential system in the cell leads to secondary damage to other systems, a so-called cascade of effects. Necrosis can arise from lack of proper care to a wound site.
Coagulative necrosis is the most common type of necrosis in which cells death happen after exogenous or endogenous stimuli, occurring after such stresses as ischemia, virus toxin, physical and chemical injury. It is manifested by severe cell rupture, denaturation and coagulation of cytoplasmic proteins.