is addison's disease genetic?
Autoantibodies to 21-hydroxylase are present in 90% of cases. Family studies have shown that Addisonâs disease has a genetic component with HLA class II the most strongly associated genetic region. Addisonâs disease is associated with DRB1*03:01-DQB1*02 (DR17, DQ2) and DRB1*04-DQB1*03:02 (DR4, DQ8). The most strongly associated DRB1*04 allele is DRB1*04:04.