what county is issaquena ms in
Issaquena County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 1,406, making it the least populous county east of the Mississippi River. Its county seat is Mayersville. Issaquena County is located in the Mississippi Delta region. The Mississippi River flows the entire western boundary of the county, and many of the earliest communities were river ports.