what causes pyroluria
â¦â¦..Perfectly Natural. Pyroluria is a genetic disorder that causes anxiety, depression and other mood disorders affecting children right through to adulthood. The onset of Pyroluria usually occurs with a traumatic incident such as moving interstate or becoming unemployed, parental divorce or death of a loved one.yroluria is a blood disorder affecting the way our red blood cells are broken down. In a person with Pyroluria certain by-products from our red blood cells accumulate in the body. These by-products aren't cleared from the body fast enough and end up binding to our nutrients.