the difference between endocrine and exocrine glands
â¢ The main difference between the endocrine gland and exocrine gland is that, an endocrine gland lacks ducts and remains as blocks of tissue. â¢ So, endocrine gland secrets chemical substances directly to the blood stream, while exocrine gland secrets its product into a duct.ifferences Between Endocrine vs Exocrine Glands. Gland is a specific structure which secrets various chemical substances such as enzymes, hormones, and metabolites. There are two types of glands in the body called endocrine glands and exocrine glands.