FGFR1 gene definition
FGFR1. A gene on chromosome 8p12 that encodes fibroblast growth factor receptor-1, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain.here is also promise for lung squamous cell carcinoma with the recent discovery that fibroblast growth factor receptor 1 (. ) amplification and discoidin domain receptor tyrosine kinase 2 (DDR2) mutations may render these patients sensitive to. inhibition and dasatinib respectively.