painkillers long term effects
Long-Term Effects of Painkillers. There are a number of unpleasant side effects associated with painkiller abuse. Mild side effects include nausea, vomiting, and diarrhea, usually caused by the way the drug interacts with opioid receptors along the digestive tract.he long-term effects also depend on how the drug is taken. Crushing and injecting the tablet into the bloodstream can cause long-term heart damage and other cardiovascular issues, and can increase the likelihood of a heart attack.