how does hypertension damage nephrons
The damage to glomerular artery and nephrons due to hypertension is focal, but kidney function decline in the late term is progressive. On one hand, high blood pressure can impair kidneys, and kidney damage aggravates hypertension; they two form a vicious circle, and cause pathological changes in normal small artery and nephrons. On the other hand, hypertension induced nephrons injury can cause compensatory high perfusion and high filtration in remaining normal nephrons.