can progesterone cause headaches
Progesterone and/or its metabolites as well as progestins can have a variable effect on migraine. There is preliminary evidence to suggest that mid-luteal elevations of progesterone and/or its metabolites could be preventative for migraine when compared to other times of the cycle. Past studies have also reported that daily oral progestins could be preventative for migraine headache in premenopausal women. Their preventative effect in premenopausal women may be secondary to induction of anovulation along with a preventative benefit of the particular progestin used.