suppress definition biology
Suppressor mutations can occur in the same gene as the initial mutation (intragenic suppression), or the two mutations may be in separate genes (intergenic suppression). Intragenic suppression may occur if the amino acid residues specified by the two sites must interact to give the normal function of the gene product.nother commonly used method is the identification of cloned genes that can suppress mutations when expressed at high levels. Cells are transformed with expression libraries, and suppressed isolates are selected. Suppression may occur when the overexpressed protein compensates for the defect of the initial mutation.