how long to cook a 4 lb brisket in the oven
1 Place a fat-trimmed 3- to 3-1/2-pound fresh beef brisket in a 13x9x2-inch baking pan. 2  Pour the cooking liquid over the meat. 3  Cover the pan with foil. 4  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time. Cover the pan with foil. 2  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time. 3  Discard the cooking liquid and, if desired, serve the sliced brisket with bottled barbecue sauce.