calexico, ca is in what county
Sponsored Topics. Calexico is a city in Imperial County, California. The population was 38,572 at the 2010 census, up from 27,109 at the 2000 census. Calexico is about 122 miles (196 km) east of San Diego and 62 miles (100 km) west of Yuma, Arizona. The name âCalexicoâ is a portmanteau of California âCal.