what is alpha one protein
Alpha 1-antitrypsin deficiency. Alpha-1 antitrypsin deficiency (Î±1-antitrypsin deficiency, A1AD, or AATD) is a genetic disorder that causes defective production of alpha-1 antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.