which condition involves skin tissue death that is usually associated with loss of circulation
Peripheral vascular disease is the reduced circulation of blood to a body part other than the brain or heart. It is caused by a narrowed or blocked blood vessel. The main cause is atherosclerosis, which is the build-up of fatty deposits that narrow a blood vessel, usually an artery. The narrowed blood vessel reduces the circulation of blood to the associated body part. Peripheral vascular disease mainly affects blood vessels of the legs and kidneys and, less commonly, the arms.