what causes severe thigh pain in both thighs?
Underlying Diseases. The sharp pain in the thigh could be due to other potential diseases. These include osteomyelitis, Ewing's sarcoma, septic arthritis, osteosarcoma, sciatica, compartment syndrome, among other infections. It could also be because of a tumor in the bone, thigh bone fractures and nervous disorders like tendinitis.
1. 1  Medical Treatments. 2  Include the use of pain reliever sprays and pain killers. 3  Antibiotics can be used if front thigh pain is caused by a bacterial infection. 4  If osteosarcoma is detected, radiation, chemotherapy and surgery will be used to treat front thigh pain.