overview of amyloidosis
Introduction. Amyloidosis is a group of diseases in which a protein called amyloid builds up in the organs and tissues. The buildup may happen in a single organ (localized) or throughout the body (systemically). Amyloid deposits can affect any organ or tissue. There are three major types of systemic amyloidosis: 1  Primary amyloidosis (AL), the most common form, occurs when bone marrow produces too much of certain fragments of antibody proteins, which build up in the bloodstream and can deposit in body tissues.