disadvantages of nanoparticles
1 9. 2  Disadvantages Of Nanoparticlesï Small size & large surface area can lead to particle aggregation .ï Physical handling of nano particles is difficult in liquid and dry forms.ï Limited drug loading.ï Toxic metabolites may form.3  10. Disadvantages Of Nanoparticlesï Small size & large surface area can lead to particle aggregation .ï Physical handling of nano particles is difficult in liquid and dry forms.ï Limited drug loading.ï Toxic metabolites may form. 2  10.