does naproxen interfere with aspirin therapy
One study of naproxen and low-dose aspirin has suggested naproxen may interfere with aspirinâs anti-platelet activity when they are co-administered. 15 However, naproxen 500 mg administered two hours before or after the administration of aspirin 100 mg did not interfere with aspirinâs antiplatelet effect. There is no data looking at doses of naproxen less than 500mg. Naproxen is available OTC only as 220mg. Prescription strengths of naproxen are 250, 375, and 500mg. Conclusions â¢ There may be a pharmacodynamic interaction between ibuprofen and aspirin when they are dosed concomitantly.