definition platelet refractoriness
â Platelet refractoriness is the inability to get an adequate increase in platelet count after transfusion (Arch Pathol Lab Med 2003;127:409, Haematologica 2005;90:247) â Immune causes: anti-platelet or anti-HLA antibodies after multiple exposures from transfusion, pregnancy or transplantation (Transfusion 2005;45:761)