how long does it take for zoloft to take effect
For those seeking answers on the efficacy â and timeliness -- of one of the U.S.'s most popular antidepressants, McGrath's death raised important questions. Just how long does Zoloft take to work? And, in the interim between first dose and full power, can it actually make symptoms worse? Symptoms such as excessive sleepiness, lack of energy or dull appetite may improve within the first two weeks of taking Zoloft. Other critical symptoms however, such as depressed mood, make take eight weeks before showing a marked turnaround [source: National Alliance on Mental Illness].