how long ibuprofen kick in
1 doctor weighed in: How long does it take for ibuprophen to kick in? 1 doctor weighed in Want a second opinion? Most drugs taken orally will require digestion and absorption into the bloodstream. For ibuprofen, since it's not a particularly strong medication, it may take as long as 45 min to feel an effect. In brief: About 30-45 min.  Most drugs taken orally will require digestion and absorption into the bloodstream.