tissue plasminogen medical definition
Medical Definition of TISSUE PLASMINOGEN ACTIVATOR. : a clot-dissolving enzyme that has an affinity for fibrin, that catalyzes the conversion of plasminogen to plasmin, that is produced naturally in blood vessel linings, and that is used in a genetically engineered form to prevent damage to heart muscle following a heart attack and to reduce .... a clot-dissolving enzyme with an affinity for fibrin that is produced naturally in blood vessel linings and is used in a genetically engineered form to prevent damage to heart muscle following a heart attack and reduce neurological damage following ischemic stroke âabbreviation TPA. ADVERTISEMENT.