how long do you cook chicken breast at 350
You should bake 2 lbs. of chicken breasts in the oven at 350  degrees for one hour if the chicken is on the bone. If the chicken  is boneless it will take less time. generally bake mine at 350 degrees for 35-40 minutes and then cut at the thickest point to see if the juices run clear. If you bake too long it becomes too dry. I always bake my thawed chicken breasts at 375 degrees for 50 min. and they come out juicy and fully cooked. The juices need to run clear.