does spironolactone contain sulfa derivatives
MD-IQ QUIZ: 1980-2014: Trends in mortality rates for major causes of death, Part 2. EVIDENCE-BASED ANSWER. Diuretics that do not contain a sulfonamide group (eg, amiloride hydrochloride, eplerenone, ethacrynic acid, spironolactone, and triamterene) are safe for patients with an allergy to sulfa.