where is desoto ms
DeSoto County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 161,252, making it the third-most populous county in Mississippi. Its county seat is Hernando. DeSoto County is part of the Memphis, TN-MS-AR Metropolitan Statistical Area (MSA). It is the second-most populous county in the MSA. The county is part of the Mississippi Delta and hill country.