what are the long term antihypertensive effects of diuretic
Diuretic Therapy for Hypertensive Patients. Many physicians consider thiazides the diuretics of choice for long-term therapy. On average, after adjustment for reductions seen with the use of placebo, thiazides induce a reduction in the systolic and diastolic blood pressures of 10 to 15 mm Hg and 5 to 10 mm Hg, respectively.
In addition, various drug-drug interactions are recognized to occur with diuretics. Diuretic-related side effects are more common and of a greater intensity with loop diuretics. Thiazide-related side effects are somewhat more common with longer-acting compounds, such as chlorthalidone and metolazone.