which neurotransmitter is affected by caffeine
Neurotransmitters Affected by Caffeine. Adenosine: Adenosine is the main neurotransmitter affected by caffeine and this is the mechanism through which all the other effects occur. Adenosine is a substance (a âpurine nucleoside) that is produced in the brain as our neurons fire.lutamate is one such âexcitatoryâ neurotransmitter which has an important role in âlong-term potentiationâ. What this means, is that glutamate increases the strength of the connection between neurons that fire at the same time.