symptoms for allergy to nickel
A more severe form is systemic nickel allergy syndrome (SNAS), which is clinically characterized by cutaneous manifestations (such as contact dermatitis, pompholyx, hand dermatitis, dyshydrosis, and urticaria), a long-term course, and systemic symptoms (such as headache, asthenia, itching, and gastrointestinal disorders related to histopathologic alterations of gastrointestinal mucosa, borderline with celiac disease).