how long does meatloaf take to cook at 350
I line a rimmed baking sheet with tin foil, place the meatloaf (in a loaf shape) on the foil in the middle of the pan, and cook at 350 degrees for 35 minutes. Although the loaf pan provides a nice shape, the only place for the fat to go is to be reabsorbed into the meat.eport Abuse. I usually cook a 1 lb meatloaf for an hour on 350. Pour the tomato sauce/ketchup topping on and bake for 10 more minutes, and the let sit to cool. Either will work, when I didn't have a loaf pan, I would use a 9x13 pan line in foil and shape into loaf form.