mthfr c677t mutation basic protocol
MTHFR C677T Mutation Basics. The MTHFR C677T mutation affects the enzyme methylenetetrahydrofolate reductase, which is the rate-limiting enzyme in the formation of 5-methyltetraydrofolate (5-MTHF), or methylfolate.If you have the C677T mutation, your ability to convert folic acid into methylfolate is significantly reduced.olate found naturally in foods, such as leafy green vegetables, does not pose a problem.The MTHFR C677T mutation may also cause high homocysteine levels, as methylfolate plays an important role in homocysteine metabolism.