is candesartan a vasodilator
In SHR treated with candesartan (MAP=146 mm Hg) or hydralazine (16 mg/kg per day; MAP=145 mm Hg), AT 2 R-induced contraction was reduced by 50%. In SHR treated with perindopril (MAP=125 mm Hg), AT 2 R stimulation induced vasodilation.n this case, stimulation of AT 2 R induced vasodilation. A further decrease in MAP, with the use of a higher dose of hydralazine or candesartan plus hydralazine, was also associated with a vasodilator effect of AT 2 R stimulation.