is aspirin more effective than tylenol for headaches
â¢ Combination medication for tension headache, including acetaminophen, aspirin, and caffeine, is more effective for pain relief than acetaminophen alone.â¢ Combination medication for tension headache may be more effective in patients with severe pain than acetaminophen alone. triple combination medication for tension headache that includes acetaminophen is more effective for pain relief than acetaminophen by itself, an international group of researchers has found.