what causes autoimmune hemolytic anemia
Autoimmune hemolytic anemia (AIHA) is mediated by autoantibodies and further subdivided according to their maximal binding temperature. Warm hemolysis refers to IgG autoantibodies, which maximally bind red blood cells at body temperature (37Â°C [98.6Â°F]).
Immune-mediated hemolysis, caused by antierythrocyte antibodies, can be secondary to malignancies, autoimmune disorders, drugs, and transfusion reactions. Microangiopathic hemolytic anemia occurs when the red cell membrane is damaged in circulation, leading to intravascular hemolysis and the appearance of schistocytes.