medical definition of splenomegaly
What is Splenomegaly, Definition and Causes. An enlarged SPLEEN. Splenomegaly signals an underlying health condition and is not itself a disorder. The spleen is a structure of lymphatic tissue. One of its key roles is to remove old or damaged BLOOD cells from circulation. Many circumstances and health conditions that cause increased numbers of blood cells in the circulation can also cause splenomegaly.