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Clemson is a city in Pickens and Anderson counties in the U.S. state of South Carolina. Clemson is home to Clemson University; in 2015, the Princeton Review cited the town of Clemson as ranking #1 in the United States for town-and-gown relations with its resident university. The population of the city was 13,905 at the 2010 census. Clemson is part of the Greenville-Spartanburg-Anderson, South Carolina Combined Statistical Area. Most of the city is in Pickens County, which is part of the Greenville-Mauldin-Easley Metropolitan Statistical Area.