corneum layer function
Epidermis is comprised of stratum corneum (horny layer) which is the outermost layer exposed to the environment, stratum granulosum (granular layer), stratum spinosum (prickle cell layer) and stratum basale (basal layer). The stratum corneum is a nonviable epidermal layer 10â15 cell layers thick, with anucleated keratinocytes (corneocytes) oriented like bricks in the surrounding lipid (that serve as a mortar) and forms the prime barrier to the transdermal delivery of actives.