where are hemoglobin polypeptides encoded
This mutation in the beta-hemoglobin gene results in the change of just a single amino acid within the polypeptide encoded by that gene. The sixth amino acid in beta-hemoglobin is normally glutamate, which has an acidic, very polar, âhydrophilicâ (water-attracting) side chain.ach red blood cell contains millions of molecules of hemoglobin, the protein that does the work of oxygen transport. The hemoglobin molecule is composed of four polypeptides (chains of amino acids): two alpha (Î±) chains, each with 141 amino acids, and two beta (Î²) chains, each with 146 amino acids.