what is abiraterone?
Acts as an inhibitor of the CYP2D6 enzyme system; avoid concurrent use with agents that are substrates of CYP2D6, especially those with narrow therapeutic indices, including thioridazine and dextromethorphan; if concurrent use is necessary, dosage â of substrate may be required. Abiraterone is a substrate of the CYP3A4 enzyme system. Concurrent use of strong CYP3A4 inducers including carbamazepine, phenobarbital, phenytoin, rifabutin, rifapentine, or rifampin should be avoided or undertaken with caution.