what is addison's disease in humans
Addisonâs disease is a severe or total deficiency of the hormones made in the adrenal cortex, caused by its destruction.There are normally two adrenal glands, located one above each kidney. The adrenal glands are really two endocrine (ductless or hormone producing) glands in one.ortisol production is regulated by another hormone, adrenocorticotrophic hormone (ACTH), made in the pituitary gland which is located just below the brain. Classical Addisonâs disease results from a loss of both cortisol and aldosterone secretion due to the near total or total destruction of both adrenal glands.