what is alkaline phosphotase
alkaline phosphatase. an isoenzyme showing optimal activity at a pH of about 10; found in bone, liver, kidney, leukocytes, adrenal cortex and other tissues, often used in clinical diagnosis of liver and/or bone damage. Called also AP; see also alkaline phosphatase.leukocyte alkaline phosphatase (LAP) the isozyme of alkaline phosphatase occurring in the leukocytes, specifically in the neutrophils; LAP activity is used in the differential diagnosis of neutrophilia, being lowered in chronic myelogenous leukemia but elevated in a variety of other disorders.. having the reactions of an alkali. 2. having a pH greater than 7.0. alkaline phosphatase an enzyme localized on cell membranes that hydrolyzes phosphate esters liberating inorganic phosphate and has an optimal pH of about 10.0.