which disorder is characterized by a defect in neuromuscular transmission
Neuromuscular transmission defects. Only myasthenia gravis will be discussed further. This disease is characterized by abnormal fatigue with exercise. Myasthenia gravis commonly affects young woman and has a predilection for ocular, facial, masticator and proximal upper extremity muscles. Typically the patients recover to some degree after rest.
myasthenia gravis. An autoimmune disease affecting neuromuscular junctions characterized by muscle weakness and fatigability. It is due to a destruction of acetylcholine receptors in the postsynaptic membrane of the neuromuscular junction.