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Scranton, PA. Sponsored Topics. Scranton is a city in the northeastern part of Pennsylvania, United States. It is the county seat of Lackawanna County and the largest principal city in the Scranton/Wilkes-Barre metropolitan area. Scranton had a population of 76,089 in 2010, according to the U.S. Census, making it Pennsylvania's sixth-most-populous city after Philadelphia, Pittsburgh, Allentown, Erie, and Reading.