temperature to cook brisket of beef in the oven
1 Cover the pan with foil. 2  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time. 3  Discard the cooking liquid and, if desired, serve the sliced brisket with bottled barbecue sauce. Cover the pan with foil. 2  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time. 3  Discard the cooking liquid and, if desired, serve the sliced brisket with bottled barbecue sauce.