immune related adverse event definition
Recently, ipilimumab was approved by the US Food and Drug Administration for the treatment of metastatic melanoma. We review the literature on managing the adverse effects and kinetics of tumor regression with ipilimumab and provide guidelines on their management.During treatment with these antibodies, a unique set of adverse effects may occur, called immune-related adverse events (irAEs).bstract. Monoclonal antibodies directed against the immune checkpoint protein cytotoxic T-lymphocyte antigen-4 (CTLA-4; CD152)âipilimumab and tremelimumabâhave been investigated in metastatic melanoma and other cancers and have shown promising results.