what two domains are closely related
Report Abuse. The 3 domains are Bacteria, Archaea, and Eukarya. The two domains that include all prokaryotes are the first two (Bacteria and Archaea).I would say the two domains most closely related are the two above, since they are both 'unicellular' prokaryotic organisms: all Eukarya have eukaryotic cells instead, and a huge number of Eukarya are multicellular.owever, domain Bacteria are more similar to members of domain Eukarya in some specific ways than they are to Archaea, and Archaea are more similar to Eukarya in some ways than they are to Bacteria.