types of homologous recombination
Double-strand breaks (DSBs) can be repaired by several homologous recombination (HR)-mediated pathways, including double-strand break repair (DSBR) and synthesis-dependent strand annealing (SDSA). a) In both pathways, repair is initiated by resection of a DSB to provide 3' single-stranded DNA (ssDNA) overhangs.t occurs frequently in many different cell types, and it has important implications for genomic integrity, evolution, and human disease. Aa Aa Aa. DNA recombination involves the exchange of genetic material either between multiple chromosomes or between different regions of the same chromosome.