crest scleroderma symptoms
What causes scleroderma is still a mystery; sufferers of scleroderma will experience a buildup of collagen in the skin and other organs and this is what leads to the symptoms of the disease.
Raynaud's phenomenon[edit] Raynaud's phenomenon is frequently the first manifestation of CREST/lcSSc, preceding other symptoms by years. Stress and cold temperature induces an exaggerated vasoconstriction of the small arteries, arterioles, and thermoregulatory vessels of the skin of the digits.