genetic cause of intellectual disability
Fragile X syndrome is the second leading genetic cause of intellectual disabilities (ID, formerly mental retardation). However, it is the leading genetic cause in males.It involves a genetic anomaly of the FRM1 gene. This is located on the X (sex-determining) chromosome.This gene normally occurs as multiple copies.ragile X is the most common genetic cause of intellectual disabilities in males. If females have a working copy of the FRM1 gene, the abnormal copy is not expressed. Even so, Fragile X remains a significant cause of ID in both females and males. There are several physical features of Fragile X.