definition of keene
Freebase(0.00 / 0 votes)Rate this definition: Keene. Keene is a city in Cheshire County, New Hampshire, United States. The population was 23,409 at the 2010 census. It is the county seat of Cheshire County. Keene is home to Keene State College and Antioch University New England, and hosts the annual Pumpkin Fest.