what is locked nucleic acids in primer
There is a clear need to design an improved controllable plasmid attachment system to add functional moieties to plasmid DNA in order to monitor and improve gene delivery and also for DNA vaccination to improve immunogenicity. We have devised an improved system based on ODNs of 100% locked nucleic acid (LNA) . LNA is an analogue of RNA or DNA. The term LNA is used to describe both nucleotide monomers, in which the ribose ring is constrained by a methylene linkage between the 2â²âoxygen and the 4â²âcarbon, and also ODNs that contain one or more monomers of LNA.