how.long does it take.for a pill.to.dissolve once swallowed
10-20 minutes for a pill that dissolves easily in an empty stomach.... 0. 0. 10-20 minutes for a pill that dissolves easily in an empty stomach. If you`ve just eaten, or if it is a timed-released pill, it will take longer. Some pills don`t dissolve in the stomach at all, but in various parts of the intestines.