how does the respiratory system regulate ph levels
2.3.1 How is the Respiratory System Linked to Acid-base Changes? Respiratory regulation refers to changes in pH due to pCO2 changes from alterations in ventilation. This change in ventilation can occur rapidly with significant effects on pH. Carbon dioxide is lipid soluble and crosses cell membranes rapidly, so changes in pCO2 result in rapid changes in [H+] in all body fluid compartments.