what agents are dna binding vesicants?
Vesicant chemotherapy agents can be divided into two categories: DNA binding and DNA non-binding (see Table 1). Vesicants that bind to nucleic acids in DNA (eg, anthracylines) bind to the DNA in the cells of healthy tissue when they extravasate from the vein and promptly cause cell death. DNA-doxorubicin complexes are released from dead cells in the tissue and are taken up by adjacent healthy cells by endocytosis.