definition mast cells and prostaglandins
Prostaglandins are found in most tissues and organs. They are produced by almost all nucleated cells. They are autocrine and paracrine lipid mediators that act upon platelets, endothelium, uterine and mast cells. They are synthesized in the cell from the essential fatty acids (EFAs).
Prostaglandin activity is also intense but short lived, though the symptoms of the resulting inflammation continue for some time after prostaglandin release stops. Mast cells are the main source of prostaglandin synthesis and secretion. Epithelial cells (surface cells of the SKIN and mucous membranes) and platelets also produce as well as respond to prostaglandins.