long term effects of protonix
A Stacy Wiegman, PharmD, Pharmacy, answered. Most risks associated with Protonix only occur after long-term use of the drug. Long term Protonix use may make it more difficult for your body to absorb vitamin B-12, causing a deficiency.tudies in animals have also revealed a risk for stomach cancer after long-term use of Protonix. The same result has not been studied in humans. As these risks tend to occur only after prolonged use, you may want to discuss short-term therapy or smaller doses of this drug with your doctor.