what are dohle bodies
1 It is due to the presence of polyribosomes and rough endoplasmic reticulum.  DÃ¶hle bodies: These are pale round to linear blue aggregates in the cytoplasm, caused by whorls of rough endoplasmic reticulum (see image to the right). This is often the earliest and first indication of toxic change. However, note that healthy cats can have low numbers of small DÃ¶hle bodies and DÃ¶hle bodies form in neutrophils with storage (storage-related artifact). Thus, DÃ¶hle bodies alone do not always indicate toxic change.