where is charleston ms
Sponsored Topics. Charleston is a city in North Central Mississippi and one of the county seats of Tallahatchie County. The population was 2,198 at the 2000 census. Charleston is located at 34Â°00â²27â³N 90Â°03â²14â³W / 34.007514Â°N 90.054009Â°W / 34.007514; -90.054009.