how long for the effect of Botox on frown lines to see results
1 Real, noticeable resultsâyou may begin to notice results within 24 to 48 hours for treatment of moderate to severe frown lines. 2  Results may vary. 3  Some patients report that being injected with BOTOXÂ® Cosmetic feels like a pinch. 4  The actual injection time takes â 10 minutes.hotos taken at maximum frown and/or full smile before and after treatment with BOTOX Â® Cosmetic at day 7. In two clinical studies for moderate to severe crowâs feet, 26.1% and 20.3% of people had â¥ 2-grade improvement at day 30.