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NYSE Holiday Closings 2017-2018. The New York Stock Exchange (NYSE) is open Monday through Friday, 9:30 a.m. to 4:00 p.m. EST. However, it closes for official U.S. holidays or in the event of a major disruption. Most U.S. exchanges follow the NYSEâs schedule. Below is a complete schedule of NYSE Holiday closings for 2017-2018.