what is genome instability
Genome instability (also âgenetic instabilityâ or âgenomic instabilityâ) refers to a high frequency of mutations within the genome of a cellular lineage.enome instability is central to carcinogenesis but also is a factor in some neurodegenerative diseases such as amyotrophic lateral sclerosis or the neuromuscular disease myotonic dystrophy. The sources of genome instability have only recently begun to be elucidated.