what is an injection site reaction
injection site reaction. An allergic, histaminic, or traumatic response of the skin and subcutaneous tissues to any substance introduced with a needle. Patient care. The injection site should be carefully monitored for redness, swelling, necrosis, or purulence. The size of any injury should be measured and the patient's level of pain assessed. Management may depend on the nature of the introduced substance. In mild cases, topical application of a cold pack may alleviate symptoms.