distance port st lucie to jacksonville
Driving distance from Jacksonville, FL to Port Saint Lucie, FL. The total driving distance from Jacksonville, FL to Port Saint Lucie, FL is 237 miles or 381 kilometers. Your trip begins in Jacksonville, Florida. It ends in Port Saint Lucie, Florida. If you are planning a road trip, you might also want to calculate the total driving time from Jacksonville, FL to Port Saint Lucie, FL so you can see when you'll arrive at your destination.