is aldosterone hydrophilic
Aldosterone is a hormone secreted by the adrenal cortex, and insulin is a peptide secreted by the pancreas. When aldosterone contacts a target cell, it binds to an intracellular receptor and migrates to the nucleus; insulin binds to extracellular receptors on the plasma membrane. What is the most likely reason for this difference? a. Aldosterone is hydrophilic and therefore must enter the aqueous environment of the cytoplasm to have an effect. b. Aldosterone is lipid-soluble and therefore easily crosses the phospholipid bilayer of the plasma membrane.