what couses alteration is mitochondria biogenesis
Mitochondrial biogenesis within muscle consists of two possible mutually inclusive alterations: [ 1 ] an increase in mitochondrial content per gram of tissue and/or [ 2 ] a change in mitochondrial composition, with an alteration in mitochondrial protein-to-lipid ratio (4).ne of the most fascinating aspects of mitochondrial synthesis is that it requires the cooperation of the nuclear and mitochondrial genomes (Figure-1). Mitochondria are unique in the fact that they house multiple copies of a small circular DNA molecule (mtDNA) comprising 16,659 nucleotides.