How long does it take to cook a pickled brisket
1 Pour the sauce over the brisket. 2  Cover the slow cooker and cook on the low-heat setting for 12 to 14 hours. 3  Or cook on the high-heat setting for 6 to 7 hours. 4  Serve the sliced brisket with the cooking liquid. Pour the sauce over the brisket. 2  Cover the slow cooker and cook on the low-heat setting for 12 to 14 hours. 3  Or cook on the high-heat setting for 6 to 7 hours. 4  Serve the sliced brisket with the cooking liquid.