what is creatine
For the use of creatine to increase athletic performance, see Creatine supplements. Not to be confused with creatinine. Creatine (/ËkriËÉtiËn/ or /ËkriËÉtÉªn/) is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells in the body, primarily muscle.This is achieved by increasing the formation of adenosine triphosphate (ATP).reatine itself can be phosphorylated by creatine kinase to form phosphocreatine, which is used as an energy reserve in skeletal muscles and the brain. Synthesis primarily takes place in the kidney and liver, with creatine then being transported to the muscles via the blood.