Question: along the hpa-axis what is what factor is the first to be released in response to stress
Answer: Stressors that are uncontrollable , threaten physical integrity , or involve trauma tend to have a high , flat diurnal profile of cortisol release ( with lower - than - normal levels of cortisol in the morning and higher - than - normal levels in the evening ) resulting in a high overall level of daily cortisol release .