Question: who holds record for most rushing yards in nfl game
Answer: Simpson Nov 25 , 1976 - Dec 5 , 1976 Most yards gained , back - to - back games , 7 days apart : 467 , Walter Payton Nov 13 , 1977 - Nov 20 , 1977 Most yards gained , back - to - back games , 4 days apart : 412 , Walter Payton Nov 20 , 1977 - Nov 24 , 1977 Most yards gained , game : 296 , Adrian Peterson Nov 4 , 2007 Most yards gained , outdoor game : 295 , Jamal Lewis Sep 14 , 2003 Most yards gained , away game : 286 , Jerome Harrison Dec 20 , 2009 Most yards gained , one half : 253 , Adrian Peterson Nov 4 , 2007 Most yards gained , first game : 194 , Alan Ameche Sep 25 , 1955 Most yards gained , game , rookie : 296 , Adrian Peterson Nov 4 , 2007 Most yards gained , one quarter : 165 , Jamaal Charles Dec 23 , 2012 Longest run from scrimmage : 99 yard ( touchdown ) , Tony Dorsett , January 3 , 1983 Highest