comments from jnims great job with your project let's start with the things i particularly enjoyed appreciated good stuff lots of informative content good organization clear prose surprisingly easy to read in a good way i have very few suggestions to make because the article is excellent overall but here are some suggestions for improvement suggested improvments circulating microvesicle formation and contents the image is extremely helpful but the caption could use some cleanup especially the placement of the numbers role on target cells and relevance in disease both of these sections contain good information but the small subsections could use more especially those that contain only one or two sentences alternately you could eliminate the subsections and lump everything together in a few larger paragraphs best of luck