meperidine analogs in vitro data for meperidine analogs with tritiated radiotracers tag dat sert opioid ki m and dopamine ic m uptake ratio e ar h win h paroxetine h damgo h dopamine dat sert dat sert co etph cnp f ndndnd cnp cl cnp i cnp me cnm p cl cn naph co etp f co etp cl co etp i co etp me co etm p cl co et naph all values are the mean sem of three experiments performed in triplicate percent inhibition at highest dose tested m some analogs of meperidine were prepared initially with a bias toward improving dat binding but it turned out that these analogs favor the sert and can even be made selective for this transporter under optimum circumstances stacey lomenzo sari izenwasser bioorganic medicinal chemistry letters volume issue december pages stacey a lomenzo sari izenwasser robert m gerdes jonathan l katz theresa kopajtic and mark l trudelllomenzo s a rhoden j b izenwasser s wade d kopajtic t katz j l trudell m l j med chem article even in light of this early warning sign the authors were still content to press ahead and modify the carboethoxy ester of the p m cl analog into a variety of spin out molecules in a futile attempt to approve dat binding jill b rhoden bioorganic medicinal chemistry volume issue october pages although this effort was unprofitable and even detrimental some of the new compounds were even more sert selective and robust none of the analogs tested produced lma effects or substituted for cocaine in drug discrimination studies the authors hypothesized that opi