what i meant was that regardless of the time taken if a given protein transports the same amount in either direction say glucose and the transport protein cannot change its cofiguration back without transporting in the reverse direction how can concentration on either side ever change ex i have particles outside inside and protein whenever goes in this changes to outside inside but can never get to outside inside because the protein's substrate binding spot is now inside which means it cannot bind a new particle from the outside without first transporting a molecule from the inside back out turning it back to out in clawx