Answer the question from the given passage. Your answer should be directly extracted from the passage, and it should be a single entity, name, or number, not a sentence.

Passage: Fresno is served by State Route 99, the main north/south freeway that connects the major population centers of the California Central Valley. State Route 168, the Sierra Freeway, heads east to the city of Clovis and Huntington Lake. State Route 41 (Yosemite Freeway/Eisenhower Freeway) comes into Fresno from Atascadero in the south, and then heads north to Yosemite. State Route 180 (Kings Canyon Freeway) comes from the west via Mendota, and from the east in Kings Canyon National Park going towards the city of Reedley. Question: What route connects Fresno with the California Central Valley?
State Route 99

Passage: Paleoclimatologists measure the ratio of oxygen-18 and oxygen-16 in the shells and skeletons of marine organisms to determine what the climate was like millions of years ago (see oxygen isotope ratio cycle). Seawater molecules that contain the lighter isotope, oxygen-16, evaporate at a slightly faster rate than water molecules containing the 12% heavier oxygen-18; this disparity increases at lower temperatures. During periods of lower global temperatures, snow and rain from that evaporated water tends to be higher in oxygen-16, and the seawater left behind tends to be higher in oxygen-18. Marine organisms then incorporate more oxygen-18 into their skeletons and shells than they would in a warmer climate. Paleoclimatologists also directly measure this ratio in the water molecules of ice core samples that are up to several hundreds of thousands of years old. Question: During what type of climate is oxygen 18 in seawater at higher levels?
lower global temperatures

Passage: The city has two universities — Newcastle University and Northumbria University. Newcastle University has its origins in the School of Medicine and Surgery, established in 1834 and became independent from Durham University on 1 August 1963 to form the University of Newcastle upon Tyne. Newcastle University is now one of the UK's leading international universities. It won the coveted Sunday Times University of the Year award in 2000. Northumbria University has its origins in the Newcastle Polytechnic, established in 1969 and became the University of Northumbria at Newcastle in 1992 as part of the UK-wide process in which polytechnics became new universities. Northumbria University was voted 'Best New University' by The Times Good University Guide 2005 and also won a much coveted company award of the 'Most IT enabled organisation' (in the UK), by the IT industry magazine Computing. Question: How many universities does Newcastle have?
two