Background There is a growing demand for women to be classified into different risk groups of developing breast cancer . The focus of the reported work is on the development of an integrated risk prediction model using a two level fuzzy cognitive map model . The proposed model combines the results of the initial screening mammogram of the given woman with her demographic risk factors to predict the post screening risk of developing BC . Methods The level 1 FCM models the demographic risk profile . A nonlinear Hebbian learning algorithm is used to train this model and thus to help on predicting the BC risk grade based on demographic risk factors identified by domain experts . The risk grades estimated by the proposed model are validated using two standard BC risk assessment models viz . Gail and Tyrer Cuzick . The level 2 FCM models the features of the screening mammogram concerning normal benign and malignant cases . The data driven Hebbian learning algorithm is used to train this model in order to predict the BC risk grade based on these mammographic image features . An overall risk grade is calculated by combining the outcomes of these two FCMs . Results The main limitation of the Gail model of underestimating the risk level of women with strong family history is overcome by the proposed model . IBIS is a hard computing tool based on the Tyrer Cuzick model that is comprehensive enough in covering a wide range of demographic risk factors including family history but it generates results in terms of numeric risk score based on predefined formulae . Thus the outcome is difficult to interpret by naive users . Besides these models are based only on the demographic details and do not take into account the findings of the screening mammogram . The proposed integrated model overcomes the above described limitations of the existing models and predicts the risk level in terms of qualitative grades . The predictions of the proposed NHL FCM model comply with the Tyrer Cuzick model for 36 out of 40 patient cases . With respect to tumor grading the overall classification accuracy of DDNHL FCM using 70 real mammogram screening images is 94.3 . The testing accuracy of the proposed model using 10 fold cross validation technique outperforms other standard machine learning based inference engines . Conclusion In the perspective of clinical oncologists this is a comprehensive front end medical decision support system that assists them in efficiently assessing the expected post screening BC risk level of the given individual and hence prescribing individualized preventive interventions and more intensive surveillance for high risk women . 


Summary: Development of an integrated breast cancer risk prediction model using a two level fuzzy cognitive map FCM model. The proposed model combines the demographic risk factors with the findings of the initial screening mammogram to elicit the hidden and impeding risk of developing breast cancer. Hebbian based learning capabilities of FCM were used to improve the modeling issue and contribute to classification of tumor grading and risk prediction. The accuracy of the system is compared with benchmark machine learning methods showing its superiority.