vania-janet/multiturn-rag-retrieval-data huggingface dataset:
Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues - PubMed
Fig. 1.
 
Insulin-degrading enzyme (IDE) was increased in App−/− tissues. A–C: IDE protein was measured in liver (n = 7), gastrocnemius (n = 6), and hippocampal tissue (n = 6–7) by Western blotting and normalized to GAPDH as a loading control. Normalized optical density is graphed as mean values ± SE. D: Ide mRNA levels were measured in hippocampus extracts (n = 4–5) and normalized to ribosomal 18S RNA as a loading control. Statistical significance (*P < 0.05) was determined by Student’s t-test. E: immunohistochemistry for IDE protein was performed on App+/+ and App−/− brain tissue sections (n = 4–6). Representative images at ×10 magnification are shown.

 Fig. 2. 

 IDE was increased in App… 

 Fig. 2. 

 IDE was increased in App −/− cell cultures. A–C : primary cell cultures… 

 Fig. 2.
 
IDE was increased in App−/− cell cultures. A–C: primary cell cultures of neurons (n = 4), astrocytes (n = 3), and microglia from App+/+, App−/− and the APP/PS1 mouse model of Alzheimer’s disease (AD) were grown and assessed for IDE protein content by Western blotting with GAPDH as a loading control. Significance (*P < 0.05) was determined by Student’s t-test. D: cultures of SIM-A9 mouse microglia cells (n = 6/condition) were treated with either scrambled RNA or anti-APP small interference (si) RNA for 1 wk. After treatment, total cellular IDE content was assessed by Western blotting with α-tubulin as a loading control. Significance (*P < 0.05) was determined by Student’s t-test. Normalized optical density is graphed as mean values ± SE.

 Fig. 3.
Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues - PubMed
Fig. 4. 

 Insulin signaling and total insulin… 

 Fig. 4. 

 Insulin signaling and total insulin levels were altered in the App −/− brain.… 

 Fig. 4.
 
Insulin signaling and total insulin levels were altered in the App−/− brain. A: total hippocampal insulin levels were measured in RIPA extractions of App+/+ and App−/− hippocampus tissue by ELISA (n = 13). B: insulin-signaling cascade markers were assessed by Western blotting in 2-mo-old App+/+ and App−/− hippocampal tissue (n = 5–6/condition). C: hippocampal synaptosomes from 2-mo-old App+/+ and App−/− animals were prepared and stimulated with 10 (n = 5/5) or 200 nM insulin (n = 6/4). Phosphorylated insulin receptor (pIR), total IR, and β-tubulin protein levels were measured using the WES system. Data were collected using the area under the peak for the specified proteins, and analysis was performed using a Student’s t-test with significance (*P < 0.05). Data are graphed as means ± SE.

 Fig. 5. 

 App −/− mice maintain glucose…

 Fig. 5. 

 App −/− mice maintain glucose tolerance on a Western diet (WD). App +/+… 

 Fig. 5.
 
App−/− mice maintain glucose tolerance on a Western diet (WD). App+/+ or App−/− mice were maintained on a normal diet (ND) or WD. A: glucose tolerance test (GTT) at 7 wk on diet (**P < 0.01, ***P < 0.001, App+/+ WD vs. App−/− WD at the indicated time points; ##P < 0.01, App+/+ WD vs. App+/+ ND).
Consortium on Long COVID - February 3, 2022 | Department of Health
Sanjiv Shah, MD - Chief Medical Officer, MetroPlus Health
Moderated by: Johanne Morne, MS – Deputy Director for Community Health, Office of Public Health; Director, AIDS Institute and Center for Community Health, New York State Department of Health

 
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Although many people with COVID-19 get better within weeks, some people continue to experience symptoms that can last months after first being infected, or may have new or recurring symptoms at a later time.1
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A guide for using NIH Image J for single slice cross-sectional area and composition analysis of the thigh from computed tomography - PubMed
Tabara Y, Okada Y, Ochi M, Ohyagi Y, Igase M.
Tabara Y, et al.
Aging Clin Exp Res. 2024 Jan 28;36(1):7. doi: 10.1007/s40520-023-02665-8.
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PMID: 36358607
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 Early immunological responses to the mRNA SARS-CoV-2 vaccine in patients with neuromuscular disorders.
 
 

Iwayama H, Ishihara N, Kawahara K, Madokoro Y, Togawa Y, Muramatsu K, Murakami A, Kuru S, Kumagai T, Ohashi W, Nanya K, Hasegawa S, Katsuno M, Okumura A.
Iwayama H, et al.
Front Immunol. 2022 Sep 29;13:996134. doi: 10.3389/fimmu.2022.996134. eCollection 2022.
Front Immunol. 2022.
PMID: 36248823
Free PMC article.
PTSD tied to autoimmune disorders 
A third theory is that pre-existing genetic or environmental risk factors might lay the groundwork for both conditions.
In any event, the study doesn't show that PTSD causes autoimmune disease—only that there's a relationship.
The study adds to others showing a link between PTSD and various physical conditions, including heart disease.
"Our findings...contribute to the growing literature highlighting the increased risk for other chronic physical diseases in veterans with PTSD and other psychiatric disorders," wrote the authors. (Biological Psychiatry, online June 28, 2014)

 






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Black Bear - NYSDEC
Often when feeding on garbage or camper's supplies, bears will eat unhealthy materials such as soap, shaving cream, insect repellant, food packaging, etc.Black Bear ManagementBear management involves bear hunting.Review the Black Bear Management Plan for New York State.Subscribe to New York Big GameJoin New York Big Game to periodically receive information about bear and deer biology, management, research, regulations and hunting in New York State.To subscribe, you need to first Subscribe to GovDelivery. Enter your email, and the information requested on the "New Subscriber" page.On the "Quick Subscribe" page you will see all the topics that you can receive email updates on from DEC. Under the "Outdoor Recreational and Commercial Activities" category, check the box next to hunting and trapping.Watchable WildlifeWhen looking for wildlife in New York visit the Watchable Wildlife webpage for the best locations for finding your favorite mammal, bird, reptile or insect. New York State has millions of acres of State Parks, forests and wildlife management areas that are home to hundreds of wildlife species, and all are open to the public.Remember when viewing wildlife:Don't feed the wildlife and leave wild baby animals where you find them.Keep quiet, move slowly and be patient. Allow time for animals to enter the area.What to Watch forBlack bears are the second largest mammal in New York State. (The moose is the largest.) Bears are excellent climbers and can run at speeds up to 25 mph or more. Look for claw marks or scars on trees and bark torn or ripped off. They are usually made to mark the tree or because they are climbing the tree in search of food.Tracks: Look for five toes, claw marks, and a large heel pad. The hind tracks are longer and may reach 7 inches long by 5 inches wide. The front tracks are smaller, but often reach 5 inches long by 5 inches wide.Scat: Bear droppings may be over an inch thick and tubular. A pile of bear scat may be very large. The scat varies with diet and food availability, based on the season.Watch a clip about black bears and check out other clips on DEC's YouTube Channel.

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California Fish and Wildlife Journal - Contents

Farhat S. Bajjaliya, Robert G. Titus, Joe R. Ferreira, and Ronald M. Coleman
A synopsis of recent history of California’s inland trout management programs: litigation and legislation. David C. Lentz and Mark A. Clifford
Book Review: The Fish in the Forest – Salmon and the Web of Life. Howard O. Clark, Jr.
Book Review: Fishing the River of Time. Howard O. Clark, Jr.
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California Fish and Game 100 (3) Summer 2014 (High Resolution)
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Notes from the Editor Vernon C. Bleich
Introduction to the special wildlife issue Charlton H. Bonham and R. Terry Bowyer
California Fish and Game 100(3): the special wildlife issue Anthony Rendon
Comparisons of intermediately ranked species in avian rank-abundance distributions from four California forests Brett J. Furnas and Reginald H. Barrett
A primer in ecoimmunology and immunology for wildlife research and management Cynthia J. Downs and Kelley M. Stewart
Shrub regeneration after removal of feral sheep from Santa Cruz Island, California Dirk H. Van Vuren
Nest site characteristics, nesting movements, and lack of long-term nest site fidelity in Agassiz’s desert tortoises at a wind energy facility in southern California Jeffrey E. Lovich, Mickey Agha, Charles B. Yackulic, Kathie Meyer-Wilkins, Curtis Bjurlin, Joshua R. Ennen, Terence R. Arundel, and Meaghan Austin
The historical distribution of bighorn sheep in the Sierra Nevada, California John D. Wehausen and Fred L. Jones
Dynamics and social issues of overpopulated deer ranges in the United States: a long term assessment Paul R. Krausman, Sonja A. Christensen, John E. Mcdonald, and Bruce D. Leopold
History of the conservation of critical deer ranges in California: concepts and terminology Eric R. Loft and Vernon C. Bleich
California Fish and Wildlife Journal - Contents

Charlton H. Bonham and E. Philip Pister
Introduction to the special fisheries issue from the California State Senate. Fran Pavley
Seasonal microhabitat selectivity by juvenile steelhead in a central California coastal river. Robert W. Holmes, Mark A. Allen, and Shannon Bros-Seeman
Potential mechanisms in the early mortality of juvenile Chinook salmon exposed concurrently to Infectious Hematopoietic Necrosis Virus (IHNV) and esfenvalerate. Mark A. Clifford, Lizabeth Bowen, Jeffry L. Stott, Ingeborg Werner, and Ronald P. Hedrick
Estimating juvenile winter-run and spring-run Chinook salmon entrainment onto the Yolo Bypass over a notched Fremont Weir. Krystal R. Acierto, Joshua Israel, Joe Ferreira, and Jason Roberts
Assessment of quagga mussel (Dreissena bugensis) veliger survival under thermal, temporal and emersion conditions simulating overland transport. James P. Snider, James D. Moore, Martha C. Volkoff, and Shauna N. Byron
Flathead catfish population estimate and assessment of population characteristics, Diamond Valley Lake, California. Quinn Granfors
Straying of late-fall-run Chinook salmon from the Coleman National Fish Hatchery into the lower American River, California. Gena R. Lasko, Robert G. Titus, Joe R. Ferreira, and Ronald M. Coleman
Investigation of the relationship between physical habitat and salmonid abundance in two coastal northern California Streams. Sean P. Gallagher, Joe Ferreira, Emily Lang, Wendy Holloway, and David W. Wright
Morphometric variation among four distinct population segments of California steelhead trout. Farhat S. Bajjaliya, Robert G. Titus, Joe R. Ferreira, and Ronald M. Coleman
A synopsis of recent history of California’s inland trout management programs: litigation and legislation. David C. Lentz and Mark A. Clifford
Book Review: The Fish in the Forest – Salmon and the Web of Life. Howard O. Clark, Jr.
Book Review: Fishing the River of Time. Howard O. Clark, Jr.
Subject Matter Index for California Fish and Game 100 (2014)
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