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An Individualized Low-Intensity Walking Clinic Leads to Improvement in Frailty Characteristics in Older Veterans - PubMed
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Astronaut Exercise - NASA
DOI: 10.1016/j.math.2016.10.009
2 English KL, Lee SM, Loehr JA, Ploutz-Snyder RJ, Ploutz-Snyder LL. Isokinetic strength changes following long-duration spaceflight on the ISS. Aerospace Medicine and Human Performance. 2015 December 1; 86(12): 68-77. DOI: 10.3357/AMHP.EC09.2015.
3 Scott JM, Feiveson AH, English KL, Spector ER, Sibonga JD, et al. Effects of exercise countermeasures on multisystem function in long duration spaceflight astronauts. npj Microgravity. 2023 February 3; 9(1): 11. DOI: 10.1038/s41526-023-00256-5.
4 English KL, Downs ME, Goetchius EL, Buxton RE, Ryder JW, et al. High intensity training during spaceflight: results from the NASA Sprint Study. npj Microgravity. 2020 August 18; 6(1): 21. DOI: 10.1038/s41526-020-00111-x.
5 Ade CJ, Broxterman RM, Moore Jr. AD, Barstow TJ. Decreases in maximal oxygen uptake following long-duration spaceflight: Role of convective and diffusive O2 transport mechanisms. Journal of Applied Physiology. 2017 April; 122(4): 968-975. DOI: 10.1152/japplphysiol.00280.2016.
6 Blottner D, Moriggi M, Trautmann G, Furlan S, Block K, et al. Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight. Antioxidants. 2024 April; 13(4): 432. DOI: 10.3390/antiox13040432
7 Scott JP, Weber T, Green DA.
FAQs • San Bruno, CA • CivicEngage
Bikeways have raised a lot of interest in the past few years. Some cities have built separate off-road bike paths. Many more have painted bike lanes on streets. Others have installed green "Bike Route" signs promoting designated bikeways.Unfortunately, the cost of both building and maintaining bikeways can be a deterrent. Initial cost can range from a few thousand dollars to paint a lane to a small fortune to build a separate path, including special bridges where needed. The City of San Bruno has established a Bicycle and Pedestrian Committee to tackle some of these issues and has also commenced the development of a Walk n' Bike Plan. For more information, please visit the Community Development Department page. 

9.
Why doesn't the City put up "children at play" signs?

The posting of generalized warning signs with "SLOW," "CHILDREN AT PLAY," or other similar messages is an often heard neighborhood request. Parental concern for the safety of children in the street near home is often the prompt for these requests, but this widespread public faith in traffic signs is misguided. The times in which such a sign is applicable are infrequent to the point where such signs are ignored by regular drivers. Worse yet, these signs often create a false sense of security for children and parents.Although some other states have posted such signs widely in residential areas, no factual evidence has been presented to document their success in reducing pedestrian accidents, operating speeds or legal liability. Studies have shown that many types of signs attempting to warn of normal conditions in residential areas have failed to achieve the desired safety benefits. If signs falsely encourage parents and children to believe they have an added degree of protection, a great disservice results.Because of these serious considerations, California does not recognize, and Federal Standards discourage, use of "Children at Play" signs. Children should be encouraged not to play in the street. Warning signs to the contrary have long been rejected since they are a direct and open suggestion that this behavior is acceptable. 

10.
Why don't you put in more stop signs?

A stop sign is one of our most valuable and effective traffic control devices when used at the right place and under the right conditions.
Facility Information and FAQs | City of Morgan Hill, CA - Official Website
Can my child work out at the CRC?CRC Fitness Center and Group Exercise Age Restrictions effective 2021The CRC welcomes children ages 8 - 9 into the Fitness Center and Group Exercise classes, when accompanied and directly supervised by a parent or guardian. Children ages 10 - 11 are welcome into the Fitness Center and Group Exercise classes, parent or guardian must be in the building. All youth in the facility are expected to use the facility for the purpose of fitness and exercise and must compete the Youth Strength Training session to use the equipment. Children are not able to sit and observe.The parent or guardian will be solely responsible for the child while they are in the fitness center or group exercise class. Each child and parent/guardian are required to review the new and updated guidelines before entering the fitness facility.The use of fitness equipment will be subject to height requirements, and the discretion of the Wellness Coach and CRC Staff.Youth 8-10 may participate (must be working out) in family friendly specific classes marked on the Group Exercise schedule. See schedule (PDF) for list of these classes. Those 12 years of age and older may use the facility without parental supervision.For all youth access in the facility, please view here: Youth Access (PDF) Senior Center Information: The Senior Nutrition Program is available Monday-Friday.  The Café registration table and dining hall open at 10:30 a.m. and lunch is served at 11:30 a.m.  Meals are a voluntary contribution of $3 for Seniors over 60 years and $8 for those under 60 years of age.The Senior Center is open weekdays from 9 a.m. - 3 p.m. with programs and activities. Visit the website for more information. Does Kids Club Require reservations? The CRC Kids' Club provides safe, programmed activities for youth 6 months to 9 years of age while parents are working out.  Please view the Kids Club page for operating hours and monthly activity calendar. Indoor pool open information:The pool is open for lap swimming and swim lessons. The shallow water play area is also be open during pool hours. Please view the CRC Indoor Pool schedule (PDF) for availability.CRC memberships provide free access to the Aquatics Center. View the Aquatics Center Outdoor pool schedule (PDF) for availability.
Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues - PubMed
doi: 10.1016/j.nbd.2019.104541. Epub 2019 Jul 23.
Neurobiol Dis. 2019.
PMID: 31349033
Free PMC article.
Review.

 
 Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.
 
 

Qiu WQ, Folstein MF.
Qiu WQ, et al.
Neurobiol Aging. 2006 Feb;27(2):190-8. doi: 10.1016/j.neurobiolaging.2005.01.004. Epub 2005 Feb 17.
Neurobiol Aging. 2006.
PMID: 16399206
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An Individualized Low-Intensity Walking Clinic Leads to Improvement in Frailty Characteristics in Older Veterans - PubMed
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 . 2019;8(4):205-209.

 doi: 10.14283/jfa.2019.16.
 

 
 
 
 
 
 
 An Individualized Low-Intensity Walking Clinic Leads to Improvement in Frailty Characteristics in Older Veterans

 
 

S E Espinoza 
 1
 , B Orsak, C P Wang, D MacCarthy, D Kellogg, B Powers, A Conde, M Moris, P R Padala, K P Padala

 

 
 Affiliations
 

 
 

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 Affiliation
 

1 Sara Espinoza, MD, 7703 Floyd Curl Drive, Mail Code 7875, San Antonio, TX 78223, Telephone: 210-617-5197, E-mail: espinozas2@uthscsa.edu, FAX: 210-949-3060.

 
 PMID:
 
 
31637407

 
 DOI:
 
 

 10.14283/jfa.2019.16
 

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Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues - PubMed
D: cultures of SIM-A9 mouse microglia cells (n = 6/condition) were treated with either scrambled RNA or anti-APP small interference (si) RNA for 1 wk. After treatment, total cellular IDE content was assessed by Western blotting with α-tubulin as a loading control. Significance (*P < 0.05) was determined by Student’s t-test. Normalized optical density is graphed as mean values ± SE.

 Fig. 3. 

 IDE activity was increased in… 

 Fig. 3. 

 IDE activity was increased in App −/− tissues. App +/+ and App −/−… 

 Fig. 3.
 
IDE activity was increased in App−/− tissues. App+/+ and App−/− hippocampus (A), liver (B), and skeletal muscle (C) (n = 6/tissue) were harvested on ice and rapidly assayed for IDE activity over the course of 1 h. The IDE activity assay uses a FRET peptide which is liberated from a quencher and exhibits increased fluorescence when cleaved by IDE. Relative fluorescent units are converted to concentrations of carboxyfluorescein (FAM) via standard curve. The data were normalized to the amount of total protein collected from each tissue. IDE activity was calculated from hippocampus (D), liver (E), and skeletal muscle (F), and significance (*P < 0.05) was determined by Student’s t-test. Data are graphed as means ± SE.

 Fig. 4. 

 Insulin signaling and total insulin… 

 Fig. 4. 

 Insulin signaling and total insulin levels were altered in the App −/− brain.… 

 Fig. 4.
 
Insulin signaling and total insulin levels were altered in the App−/− brain. A: total hippocampal insulin levels were measured in RIPA extractions of App+/+ and App−/− hippocampus tissue by ELISA (n = 13).
An Individualized Low-Intensity Walking Clinic Leads to Improvement in Frailty Characteristics in Older Veterans - PubMed
Health Psychol. 2022.
PMID: 35389690
Free PMC article.

 
 A Behavioral Lifestyle Intervention to Improve Frailty in Overweight or Obese Older Adults with Type 2 Diabetes: A Feasibility Study.
 
 

Jiwani R, Wang J, Li C, Dennis B, Patel D, Gelfond J, Liu Q, Siddiqui N, Bess C, Monk S, Serra M, Espinoza S.
Jiwani R, et al.
J Frailty Aging. 2022;11(1):74-82. doi: 10.14283/jfa.2021.17.
J Frailty Aging. 2022.
PMID: 35122094
Free PMC article.

 
 Change in Physical Performance Correlates with Decline in Quality of Life and Frailty Status in Head and Neck Cancer Patients Undergoing Radiation with and without Chemotherapy.
 
 

Farrugia M, Erickson K, Wendel E, Platek ME, Ji W, Attwood K, Ma SJ, Gu F, Singh AK, Ray AD.
Farrugia M, et al.
Cancers (Basel). 2021 Apr 1;13(7):1638. doi: 10.3390/cancers13071638.
Cancers (Basel). 2021.
PMID: 33915867
Free PMC article.

 
 A geriatrics walking clinic improves hemoglobin A1c and timed gait in older veterans with type 2 diabetes.
 
 

Jiwani R, Wang CP, Orsak B, MacCarthy D, Kellogg D, Powers B, Wang J, Padala P, Padala K, Espinoza S.
Jiwani R, et al.
Geriatr Nurs. 2021 Mar-Apr;42(2):566-569. doi: 10.1016/j.gerinurse.2020.10.001. Epub 2020 Nov 4.
Geriatr Nurs. 2021.
PMID: 33158625
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An Individualized Low-Intensity Walking Clinic Leads to Improvement in Frailty Characteristics in Older Veterans - PubMed
Is Trunk Posture in Walking a Better Marker than Gait Speed in Predicting Decline in Function and Subsequent Frailty?
 
 

Merchant RA, Banerji S, Singh G, Chew E, Poh CL, Tapawan SC, Guo YR, Pang YW, Sharma M, Kambadur R, Tay S.
Merchant RA, et al.
J Am Med Dir Assoc. 2016 Jan;17(1):65-70. doi: 10.1016/j.jamda.2015.08.008. Epub 2015 Sep 26.
J Am Med Dir Assoc. 2016.
PMID: 26410107

 
 Erratum.
 
 

[No authors listed]
[No authors listed]
Mult Scler. 2016 Oct;22(12):NP9-NP11. doi: 10.1177/1352458515585718. Epub 2015 Jun 3.
Mult Scler. 2016.
PMID: 26041800

 
 Measurement of gait speed in older adults to identify complications associated with frailty: A systematic review.
 
 

Pamoukdjian F, Paillaud E, Zelek L, Laurent M, Lévy V, Landre T, Sebbane G.
Pamoukdjian F, et al.
J Geriatr Oncol. 2015 Nov;6(6):484-96. doi: 10.1016/j.jgo.2015.08.006. Epub 2015 Sep 9.
J Geriatr Oncol. 2015.
PMID: 26362356
Review.

 
 Frailty and technology: a systematic review of gait analysis in those with frailty.
 
 

Schwenk M, Howe C, Saleh A, Mohler J, Grewal G, Armstrong D, Najafi B.
Schwenk M, et al.
Gerontology. 2014;60(1):79-89. doi: 10.1159/000354211. Epub 2013 Aug 15.
Gerontology.
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In addition, the basketball gym has retractable bleachers that can seat up to 250 spectators!  

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An Individualized Low-Intensity Walking Clinic Leads to Improvement in Frailty Characteristics in Older Veterans - PubMed
An Individualized Low-Intensity Walking Clinic Leads to Improvement in Frailty Characteristics in Older Veterans - PubMed

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