Mathematical analysis of the effect of a pulse vaccination to an HBV mutation. It has been proven that vaccine can play an important role for eradication of hepatitis B infection. When the mutant strain of virus appears, it changes all treatments strategies. The current problem is to find the critical vaccine threshold which can stimulate the immune system for eradicate the virus, or to find conditions at which mutant strain of the virus can persist in the presence of a CTL vaccine. In this paper, the dynamical behavior of a new hepatitis B virus model with two strains of virus and CTL immune responses is studied. We compute the basic reproductive ratio of the model and show that the dynamic depend of this threshold. After that, we extend the model incorporating pulse vaccination and we find conditions for eradication of the disease. Our result indicates that if the vaccine is sufficiently strong, both strains are driven to extinction, assuming perfect adherence.

Ergodic Stationary Distribution of a Stochastic Hepatitis B Epidemic Model with IntervalValued Parameters and Compensated Poisson Process Hepatitis B epidemic was and is still a rich subject that sparks the interest of epidemiological researchers. The dynamics of this epidemic is often modeled by a system with constant parameters. In reality, the parameters associated with the Hepatitis B model are not certain, but the interval in which it belongs to can readily be determined. Our paper focuses on an imprecise Hepatitis B model perturbed by Levy noise due to unexpected environmental disturbances. This model has a global positive solution. Under an appropriate assumption, we prove the existence of a unique ergodic stationary distribution by using the mutually exclusive possibilities lemma demonstrated by Stettner in 1986. Our main effort is to establish an almost perfect condition for the existence of the stationary distribution. Numerical simulations are introduced to illustrate the analytical results.