Study on the Nanoscaled Molecules Used in Treatment for Melanoma Using Biochemical and Computational Analysis When the production of Reactive Oxygen Species exceeds the capacity for antioxidation, the result is cell damage or cell death in melanoma caused by toxicity. This paper conducts a study on the chemopreventive agents and the resulting chemoprevention. For example, plant polyphenols are examined for their potential to inhibit the process of reactive chain reactions in the UVexposed skin. In addition, the paper analyzes the chemical and physical properties of the polyphenols that may be useful for skin diseases associated with solar UV radiationinduced inflammation and oxidative stress. Using computational programs, various information about molecules of polyphenols with functional groups is extracted. The optimization energies (kJmol) of the molecules are computed and used to determine the characteristics and stability of the molecules. Dipole moments (D) are used to determine the reactivity of the molecules. Measurement of the moleculesu0027 stability and reactivity allows evaluation of polyphenols and their ability to inhibit reactive chain reactions caused by Reactive Oxygen Species.

Effect of Epigallocatechin3gallate on DMPC Oxidation Revealed by Infrared Spectroscopy The daily exposure of skin cells to the sun increases the rate of production of free radicals, which threatens the healthy appearance of skin and, even more worrying, damages the structural integrity of tissues and DNA, causing inflammation and carcinogenesis. This work demonstrates the feasibility of using natural agents, in particular tea catechins, in protecting lipidic membranes from oxidative stressinduced by UV radiation exposure. For that purpose, thin cast films prepared from vesicular suspensions of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylcholine  ()epigallocatechin3gallate (DMPC  EGCG) were deposited onto calcium fluoride supports and irradiated with 254 nm UV radiation. The molecular damage after irradiation with UV light was analysed by infrared (IR) together with 2D correlation spectroscopies. Results revealed that the DMPC phospholipid polar moiety is the most vulnerable and sensitive structural target of UV radiation. To check if the presence of the EGCG molecules is protecting the lipids, the principal components analysis (PCA) mathematical method was applied, allowing to conclude that EGCG slows down the cascade of the oxidantevents in the lipid, thus protecting the polar moiety of the lipid.