Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted polymers (MIPs) and surface imprinted polymers (SIPs) have great potential to be robust artificial receptors. Therefore, extensive studies have been reported to develop MIPsSIPs for the detection of infectious diseases with high selectivity and reliability. In this review, we discuss mechanisms of recognition events between imprinted polymers with different biomarkers, such as signaling molecules, microbial toxins, viruses, and bacterial and fungal cells. Then, various preparation methods of MIPsSIPs for electrochemical biosensors are summarized. Especially, the methods of electropolymerization and microcontact imprinting are emphasized. Furthermore, applications of MIPsSIPs based electrochemical biosensors for infectious disease detection are highlighted. At last, challenges and perspectives are discussed.

Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6 Interleukin 6 (IL6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer realtime monitoring of IL6 and facilitate early prognosis of lifethreatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical and fluorescencebased detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signaltonoise ratio, high specificity, ultrasensitivity, and wide dynamic range. In this review, the pleiotropic role of IL6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications.