Peripheral extracorporeal membrane oxygenation with interposition graft. The outflow is highly dependent on the anastomotic angle Venoarterial extracorporeal membrane oxygenation (VAECMO) is a technique that supports vital functions through extracorporeal circulation, by raising blood oxygenation, reducing blood carbon dioxide values (CO2), increasing cardiac output and acting on body temperature. In conditions of severe respiratory andor cardiac insufficiency, it allows to put the heart and lungs at rest by compensating for their ventilatory and pump functions. The correct distribution of blood flows between the upper and lower parts of the body is of considerable importance to avoid the onset of serious diseases in the patient. This study presents a mathematical model for the analysis of blood flows according to the configuration of the connection between the ECMO system and the vascular system.

A physiological control system for ECGsynchronized pulsatile pediatric ventricular assist devices Abstract   Ventricular assist devices (VADs) are mechanical pumps used to provide support to the circulatory system of patients with ventricular dysfunction that are waiting for heart transplantation. The majority of pulsatile VADs are used in the filltoempty mode or the asynchronous mode at a fixed rate. However, when this support lasts for weeks or months, physiological control systems can improve the treatment by changing VAD operation in response to changes in the cardiovascular system. In this work, a physiological control system was developed to adjust the pump ejection pressure at each cardiac cycle to keep the mean arterial pressure at a specified reference value. A polynomial controller was used, and the optimum parameters for this controller were determined by using the interiorpoint method to solve a constrained minimization problem. A heartbeat detection algorithm based on electrocardiogram signals (ECG) is used in such a way the control system works in synchronization with the physiological heartbeat. Mathematical models of the pediatric cardiovascular system (pCVS) and a pulsatile pediatric pump were used to evaluate the cardiovascular response under ventricular assistance. Computational simulation results were analyzed, and based on them one may conclude that the synchronous physiological control system adapted the cardiovascular response to the changes in references values, defined in accordance with the patient clinical status.