Mechanisms of Atractylodis Macrocephalae Rhizoma against Chronic Gastritis Atractylodis Macrocephalae Rhizome (AMR) has been identified in traditional Chinese medicine (TCM) with xe2x80x9cspleen tonifyingxe2x80x9d effect. In TCM clinical practices, AMR has been widely used against xe2x80x9cspleen deficiencyxe2x80x9d syndrome associated diseases e.g., chronic gastritis. However, the underlying mechanisms are still under exploration. In this study, based on evidenced knowledge items of bioactive compounds and targeted proteins, bioinformatics analysis towards underlying mechanisms was deployed. As a result, a key candidate process of regulation on secretion was identified. For all 14 network participating proteins, 8 had been evidenced with regulations on secretion of gastritis acid. Gene expression data of chronic gastritis also provide support evidences. In brief, the positive regulation on protein secretion of gastric acid delivered by AMR might be the underlying mechanism of xe2x80x9cspleen tonifyingxe2x80x9d observed in TCM clinical practices.

Antirheumatoid Arthritis Mechanisms of Angelicae Pubescentis Radix Angelicase Pubescentis Radix (APR) has been used in the practices of traditional Chinese medicine (TCM) with antirheumatoid arthritis (RA) effects called xe2x80x9cwinddampnessdispelling and cold dispersingxe2x80x9d. In TCM prescriptions and patient medicines, APR has been widely adopted against RA. Till now, the antirheumatoid mechanisms are still obscure. In this study, bioactive compounds and targeted proteins based on experiment evidences were collected. Then, bioinformatics analysis towards RA was deployed. As a result, five RA associated biological processes were enriched with proteins targetedregulated by APR e.g. ossification, osteoclast differentiation, positive regulation of lymph activation and regulation of T and B cell. The result can also be validated with bioinformatics tools and RA microarray data. In short, the antiRA effect of APR recognized in TCM may associated with regulations on bone formation and inflammations.