Chiral Plasmonics and Their Potential for PointofCare Biosensing Applications There has been growing interest in using strong field enhancement and light localization in plasmonic nanostructures to control the polarization properties of light. Various experimental techniques are now used to fabricate twisted metallic nanoparticles and metasurfaces, where strongly enhanced chiral nearfields are used to intensify circular dichroism (CD) signals. In this review, stateoftheart strategies to develop such chiral plasmonic nanoparticles and metasurfaces are summarized, with emphasis on the most recent trends for the design and development of functionalizable surfaces. The major objective is to perform enantiomer selection which is relevant in pharmaceutical applications and for biosensing. Enhanced sensing capabilities are key for the design and manufacture of labonachip devices, commonly named pointofcare biosensing devices, which are promising for nextgeneration healthcare systems.

Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6 Interleukin 6 (IL6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer realtime monitoring of IL6 and facilitate early prognosis of lifethreatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical and fluorescencebased detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signaltonoise ratio, high specificity, ultrasensitivity, and wide dynamic range. In this review, the pleiotropic role of IL6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications.