CBOWRA: A Representation Learning Approach for Medication Anomaly Detection Electronic health record is an important source for clinical researches and applications, and errors inevitably occur in the data, which lead to severe damages to both patients and hospital services. One of such errors is the mismatch between diagnose and prescription, which we address as xe2x80x9cmedication anomalyxe2x80x9d in the paper, and clinicians used to manually identify and correct them. With the development of machine learning techniques, researchers are able to train specific model for the task, but the process still requires expert knowledge to construct proper features, and few semantic relations are considered. In this paper, we propose a simple, yet effective detection method that tackles the problem by detecting the semantic inconsistency between diagnoses and prescriptions. Unlike traditional outlier or anomaly detection, the scheme uses continuous bag of words to construct the semantic connection between specific central words and their surrounding context. The detection of medication anomaly is transformed into identifying the least possible central word based on given context. To help distinguish the anomaly from normal context, we also incorporate a ranking accumulation strategy. The experiments were conducted on two real hospital electronic medical records, and the  topN  accuracy of the proposed method increased by 3.91 to 10.91% and 0.68 to 2.13% on the datasets, respectively, which is highly competitive to other traditional machine learningbased approaches.

Unsupervised Annotation of Phenotypic Abnormalities via Semantic Latent Representations on Electronic Health Records The extraction of phenotype information which is naturally contained in electronic health records (EHRs) has been found to be useful in various clinical informatics applications such as disease diagnosis. However, due to imprecise descriptions, lack of gold standards and the demand for efficiency, annotating phenotypic abnormalities on millions of EHR narratives is still challenging. In this work, we propose a novel unsupervised deep learning framework to annotate the phenotypic abnormalities from EHRs via semantic latent representations. The proposed framework takes the advantage of Human Phenotype Ontology (HPO), which is a knowledge base of phenotypic abnormalities, to standardize the annotation results. Experiments have been conducted on 52,722 EHRs from MIMICIII dataset. Quantitative and qualitative analysis have shown the proposed framework achieves stateoftheart annotation performance and computational efficiency compared with other methods.