Molecular Action Mechanisms of the Traditional Chinese Medicine in the Treatment of Rheumatoid Arthritis Based on the Computer Simulation The rheumatoid arthritis (RA), also known as rheumatoid, is a chronic systemic inflammatory disease with unknown etiology. At present, it is recognized that the rheumatoid arthritis is an autoimmune disease. It may be related to endocrine, metabolic, nutritional, geographical, occupational, psychological and social environment differences, the bacterial and viral infections and the genetic causes. Chronic, symmetrical, polysynovial arthritis and extraarticular lesions are the main clinical manifestations and belong to the autoimmune inflammatory diseases. Based on the computer simulation, the molecular mechanism of the traditional Chinese medicine in the treatment of the rheumatoid arthritis is studied, which provides an important platform for extending the value of the computer simulation technology.

Antirheumatoid Arthritis Mechanisms of Angelicae Pubescentis Radix Angelicase Pubescentis Radix (APR) has been used in the practices of traditional Chinese medicine (TCM) with antirheumatoid arthritis (RA) effects called xe2x80x9cwinddampnessdispelling and cold dispersingxe2x80x9d. In TCM prescriptions and patient medicines, APR has been widely adopted against RA. Till now, the antirheumatoid mechanisms are still obscure. In this study, bioactive compounds and targeted proteins based on experiment evidences were collected. Then, bioinformatics analysis towards RA was deployed. As a result, five RA associated biological processes were enriched with proteins targetedregulated by APR e.g. ossification, osteoclast differentiation, positive regulation of lymph activation and regulation of T and B cell. The result can also be validated with bioinformatics tools and RA microarray data. In short, the antiRA effect of APR recognized in TCM may associated with regulations on bone formation and inflammations.