Patent application EP20177110A (EP), filed 2020-05-28
Publication number: EP3744775A1
Title: BLOOD STORAGE CONTAINERS MADE OF POLYVINYL CHLORIDE AND MIXED PLASTICIZERS
Abstract: Flexible, blood storage containers are disclosed. The blood storage containers are made of polyvinyl chloride and a mixture of at least two plasticizers in selected ratios.
IPC codes: A01N   1/    02            A I
A61J   1/    14            A I
C08K   5/    11            A I
C08K   5/    12            A I
C08L  27/    06            A I
Claims: number: 1
text: A flexible blood storage container comprising a pair of walls defining an interior chamber and at least one access port, said container made of a polymeric material comprising polyvinyl chloride and a mixture of least two extractable plasticizers comprising at least 78% 1, 2 cyclohexanedicarboxyylic acid diisononyl ester and up to 22% acetyl tri-n-butyl citrate of the at least two plasticizer mixture.
number: 2
text: The flexible storage container of Claim 1 wherein said mixture of extractable plasticizers comprises at least 85% 1, 2 cyclohexanedicarboxyylic acid diisononyyl ester and up to 15% acetyl tri-n-butyl citrate.
number: 3
text: The flexible storage container of Claim 1 wherein said mixture of extractable plasticizers comprises at least 90% 1, 2 cyclohexanedicarboxyylic acid diisononyl ester and up to 10 % acetyl tri-n-butyl citrate.
number: 4
text: The flexible storage container of Claim 1 wherein said mixture of extractable plasticizers comprises at least 95% 1, 2 cyclohexanedicarboxyylic acid diisononyl ester and up to 5 % acetyl tri-n-butyl citrate.
number: 5
text: The flexible blood storage container of any one of Claims 1 through 4 wherein said polymeric material further comprises a stabilizer comprising epoxidized vegetable oil and optionally a co-stabilizer comprising a metal stearate.
number: 6
text: A flexible blood storage container comprising a pair of walls defining an interior chamber and at least one access port, said container made of a polymeric material comprising polyvinyl chloride and at mixture of least two extractable plasticizers comprising at least 75% di-2-ethylhexyl terephthalate ester and up to 25% acetyl tri-n-butyl citrate of the plasticizer mixture.
number: 7
text: The flexible blood storage container of Claim 6wherein said mixture of extractable plasticizers comprises at least 80% di-2-ethylhexyl terephthalate ester and up to 20% acetyl tri-n-butyl citrate.
number: 8
text: The flexible blood storage container of Claim 6 wherein said mixture of plasticizers comprises at least 85% di-ethylhexyl terephthalate ester and up to 15% acetyl tri-n-butyl citrate.
number: 9
text: The flexible blood storage container of Claim 6 wherein said mixture of plasticizers comprises at least 90% di-ethyl hexyl terephthalate ester and up to 10 % acetyl tri-n-butyl citrate.
number: 10
text: The flexible, blood storage container of Claim 6 wherein said mixture of plasticizers comprises at least 95% di-ethyl hexyl terephthalate ester and up to 5% acetyl tri-n-butyl citrate.
number: 11
text: The flexible blood storage container of any one of Claims 6 through 10 wherein said polymeric material further comprises a stabilizer comprising epoxidized vegetable oil and optionally a co-stabilizer comprising a metal stearate .
number: 12
text: A flexible blood storage container comprising a pair of walls defining an interior chamber and at least one access port, said container made of a polymeric material comprising polyvinyl chloride and at mixture of least two extractable plasticizers comprising 1, 2 cyclohexanedicarboxyylic acid diisononyl ester and di-2-ethylhexyl terephthalate ester.
number: 13
text: The flexible blood storage container of Claim 12 wherein said polymeric material further comprises a stabilizer comprising epoxidized vegetable oil and optionally a co-stabilizer comprising a metal stearate.
number: 14
text: The flexible blood storage container comprising a pair of walls defining an interior chamber and at least one access port, said container made of a polymeric material comprising polyvinyl chloride and at mixture of least two extractable plasticizers comprising di-2-ethylhexyl terephthalate ester and acetyl tri-n-hexyl citrate.
number: 15
text: The flexible blood storage container of Claim 14 wherein said mixture of plasticizers comprises at least 90% di-ethyl hexyl terephthalate ester and up to 10 % acetyl tri-n-hexyl citrate.
number: 16
text: The flexible blood storage container of any one of Claims 14 through 15 wherein said polymeric material further comprises a stabilizer comprising epoxidized vegetable oil and optionally a co-stabilizer comprising a metal stearate.
number: 17
text: The flexible blood storage container comprising a pair of walls defining an interior chamber and at least one access port, said container made of a polymeric material comprising polyvinyl chloride and at mixture of least two extractable plasticizers comprising di-2-ethylhexyl terephthalate ester and butyl tri-n- hexyl citrate.
number: 18
text: The flexible blood storage container of Claim 17 wherein said polymeric material further comprises a stabilizer comprising epoxidized vegetable oil and optionally a co-stabilizer comprising a metal stearate.
Office action: search_report, dated 2020-12-02
Rejection reasons: novelty_epc_54
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ref_type: patent
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ref_id: - RADWANSKI, ET AL.: "E-Sol 5 Additive Solution improves Storage of Red Blood Cells in DINCH Plasticized PVC Storage Containers", ABSTRACT PRESENTATIONS FROM THE AABB ANNUAL MEETING AND CTTXPO SAN DIEGO, vol. 51, 9 December 2011 (2011-12-09), pages 66A, XP055512918
ref_type: npl
severity: background
ref_id: US2017172847A1
ref_type: patent
severity: background
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ref_type: patent
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ref_id: - YUJI HAISHIMA ET AL: "Screening study on hemolysis suppression effect of an alternative plasticizer for the development of a novel blood container made of polyvinyl chloride", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS, vol. 102, no. 4, 1 May 2014 (2014-05-01), pages 721 - 728, XP055127428, ISSN: 1552-4973, DOI: 10.1002/jbm.b.33052
ref_type: npl
severity: background
ref_id: US2014276527
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severity: background
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ref_type: patent
severity: novelty_destroying
Final disposition: pending (2020-12-02)