Patent application EP20164975A (EP), filed 2020-03-23
Publication number: EP3714940A1
Title: PHARMACEUTICAL FORMULATION FOR ORAL USE CONTAINING HONEY AND PLANT EXTRACTS WITH AN ASSAYED POLYSACCHARIDE AND MUCILAGE CONTENT FOR THE TREATMENT OF PRODUCTIVE AND NON-PRODUCTIVE COUGHS AND THROAT DISEASES
Abstract: The present invention relates to formulations containing honey and plant extracts with an assayed polysaccharide and mucilage content for the treatment of dry and productive cough and throat ailments.
IPC codes: A61K  36/   185            A I
A61P  11/    14            A I
A61K  35/   644            A I
A61K  36/    28            A I
A61K  36/    57            A I
A61K  36/    68            A I
A61K  47/    12            A I
A61K  47/    26            A I
A61K  47/    36            A I
A61K  47/    46            A I
A61K   9/    00            A I
Claims: number: 1
text: Pharmaceutical formulation containing:
number: 2
text: The pharmaceutical formulation according to claim 1 wherein the pharmaceutically acceptable grade honey is acacia honey.
number: 3
text: The pharmaceutical formulation according to claim 1 or 2 wherein the pharmaceutically acceptable grade honey is present in an amount ranging between 8% w/w and 40% w/w on the total weight of the formulation.
number: 4
text: The pharmaceutical formulation according to claim 3 wherein the pharmaceutically acceptable grade honey is present in an amount ranging between 15% w/w and 35% w/w on the total weight of the formulation.
number: 5
text: The pharmaceutical formulation according to each of the previous claims wherein the Malva mucilage is present in an amount ranging between 1% w/w and 10% w/w on the total weight of the formulation.
number: 6
text: The pharmaceutical formulation according to claim 5 wherein the Malva mucilage is present in an amount ranging between 1.5% w/w and 4.5% w/w on the total weight of the formulation.
number: 7
text: The pharmaceutical formulation according to each of the preceding claims wherein the extract or mixture of extracts is present in an amount ranging between 1% and 8% w/w on the total weight of the formulation.
number: 8
text: The pharmaceutical formulation according to claim 7 wherein the extract or the mixture of extracts is present in an amount ranging between 1.5% w/w and 4.5% w/w on the total weight of the formulation.
number: 9
text: The pharmaceutical formulation according to each of the previous claims wherein the Malva mucilage is mucilage of Malva sylvestris.
number: 10
text: The pharmaceutical formulation according to each of the previous claims wherein the extracts of one or more plants are extracts of Aloe barbadensis, Aloe vera, Helichrysum italicum, Helichrysum stoechas Moench, Inula helenium, Plantago major, Matricaria recutita or Commiphora myrrha.
number: 11
text: The pharmaceutical formulation according to each of the previous claims containing a further mucoadhesive agent selected from xanthan gum, PVP and hyaluronic acid.
number: 12
text: The pharmaceutical formulation according to each of the preceding claims, further containing a carrier, diluent, anticaking agent, disintegrating agent, emulsifier, sweetener, gelling agent, preservative, antioxidant, buffering agent, pH adjuster, flavouring agent, trace element and/or mixtures thereof.
number: 13
text: The pharmaceutical formulation according to claim 1 comprising:
number: 14
text: The pharmaceutical formulation according to each of the previous claims in the form of a solution, oral spray, tablet or syrup.
number: 15
text: The pharmaceutical formulation according to each of the preceding claims for oral use in the treatment of dry and productive cough and throat ailments.
Office action: search_report, dated 2020-09-30
Rejection reasons: inventive_step_epc_56
Prior art cited: ref_id: - DATABASE TKDL 1872, MOHAMMAD AZAM  KHAN: "Malookhiyah", Database accession no. EA1B/112L
ref_type: npl
severity: background
ref_id: - DATABASE TKDL 2005, HARITA SAMHITA-: "Kshaudra Madhu Guna", Database accession no. AJ/180B
ref_type: npl
severity: background
ref_id: - DATABASE TKDL 1998, PAṆḌITA  NARAHARI: "Kumārī", Database accession no. RS/4680
ref_type: npl
severity: background
ref_id: - DATABASE TKDL 1874, ZIYA AL- DIN ABDULLAH  IBN AL- BAITAR: "Dawa Baraae Zeequn Nafas", XP055928956, Database accession no. MH2/207D
ref_type: npl
severity: background
ref_id: - DATABASE TKDL 1872, MOHAMMAD AZAM  KHAN: "Matbookh Barae Humma", Database accession no. EA1B/33F
ref_type: npl
severity: background
ref_id: - DATABASE GNPD [online] MINTEL; 18 September 2018 (2018-09-18), ANONYMOUS: "Concentrated Fluid for Children", XP093051102, retrieved from https://www.gnpd.com/sinatra/recordpage/5966581/ Database accession no. 5966581
* abstract *
ref_type: npl
severity: background
ref_id: US2016331794A1
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Final disposition: pending (2020-09-30)