Patent application EP20020253A (EP), filed 2020-05-28
Publication number: EP3747467A2
Title: A CRYOSYSTEM COMPRISING NANOPARTICLES FOR TREATING A BODY PART OF AN INDIVIDUAL BY CRYOTHERAPY
Abstract: [0001]    The invention relates to a cryo-system for treating a body part of an individual by cryotherapy comprising two parts:
a) a first part, which is a cryo-probe wherein:
i) the cryo-probe is suitable for an internal cooling action as it comprises a penetrating segment which is in communication with a cryogen source and which is at least smaller than 1/10th of the biggest volume of said body part and/or has at least one dimension smaller than 1 cm;
or
ii) the cryo-probe is suitable for an external cooling action as it comprises a non-penetrating segment in communication with a cryogen source,
and

b) a second part, which is either:
i) an assembly of at least two nanoparticles characterized in that this assembly comprises at least two nanoparticles bound to each other or associated with each other via binding or associating material, or
ii) at least one nanoparticle that comprises iron and at least one other metal than iron, wherein the assembly of at least two nanoparticles or the at least one nanoparticle is meant to be cooled down by the cryo-probe or by switching on the cryo-probe.
IPC codes: A61B  18/    02            A I
A61F   7/    00            A I
A61K  41/    00            A I
A61K  47/    36            A I
A61K  49/    18            A I
A61K   9/    00            A I
A61K   9/   127            A I
A61N   5/    06            A I
A61P  31/    00            A I
A61P  35/    00            A I
Claims: number: 1
text: A cryo-system for treating a body part of an individual by cryotherapy comprising two parts:
number: 2
text: The cryo-system for use according to claim 1 in a method of treating a body part of an individual by cryotherapy comprising at least one of the following steps:
number: 3
text: The cryo-system for use according to claim 1, wherein the initial temperature and/or the final temperature is/are physiological temperature(s), wherein the physiological temperature is a temperature selected from the group consisting of: i) the temperature of the body part before or after the body part is treated by the method according to claim 2, ii) the temperature of an individual that does not suffer from fever, iii) a temperature comprised between 25 and 45 °C, iv) the temperature of an individual or of its body part or of its blood that is not above by more than 5 °C than the average temperature of this individual or of its blood or of its body part measured over the course of the life of this individual, and v) the temperature of an individual or of its body part or of its blood that is not below by more than 5 °C than the average temperature of this individual or of its blood or of its body part measured over the life of this individual.
number: 4
text: The cryo-system for use according to any of claim 2 to 3, wherein the cooling temperature has at least one characteristic selected from the group consisting of:
number: 5
text: The cryo-system for use according to any of claim 2 to 4, wherein the steps of the method are characterized by at least one of the following properties:
number: 6
text: The cryo-system for use according to any of claim 2 to 5, wherein the cooling time t<1> and the warming time t<2> are characterized by at least one property selected in the group consisting of:
number: 7
text: The cryo-system for use according to any of claim 2 to 6, wherein the cooling temperature is larger than -40 °C.
number: 8
text: The cryo-system for use according to any of the preceding claims, where the cryo-stem is a kit or a combination of:
number: 9
text: Use of the cryo-system, according to any of the preceding claims, to store or retain the cold in a body part of an individual during a cryotherapy.
number: 10
text: Use of the cryo-system according to claim 9, wherein:
number: 11
text: Use of the cryo-system according to claim 9 or 10, wherein:
number: 12
text: Use of the cryo-system according to any of claim 9 to 11, wherein the second part has at least one property selected from the group consisting of:
number: 13
text: Use of the cryo-system according to any of claim 9 to 12, wherein the cryotherapy is a non-ice-ball cryotherapy or a nanoparticle-ice-ball-cryotherapy, characterized in that:
number: 14
text: Use of the cryo-system according to claim 9, 10, 11, 12 or 13, to stimulate or activate the immune system.
Office action: search_report, dated 2020-12-09
Rejection reasons: inventive_step_epc_56
Prior art cited: ref_id: EP3363496A1
ref_type: patent
severity: background
ref_id: IB2018000218W
ref_type: patent
severity: background
ref_id: WO2018150266A1
ref_type: patent
severity: background
ref_id: EP19020331A
ref_type: patent
severity: background
ref_id: US201916412933A
ref_type: patent
severity: background
ref_id: WO2018001460A1
ref_type: patent
severity: background
ref_id: WO2019106428A1
ref_type: patent
severity: background
ref_id: EP18827221A
ref_type: patent
severity: background
ref_id: US201816486574A
ref_type: patent
severity: background
ref_id: - YIU ET AL., INT. J. ANGIOL., vol. 16, 2008, pages 1
ref_type: npl
severity: background
ref_id: WO2018150266A1
ref_type: patent
severity: background
ref_id: EP3569247A1
ref_type: patent
severity: background
ref_id: - LI J ET AL: "Synthesis of antiferromagnetic gadolinium dihydride nanoparticles and its large cryogenic magneto-caloric effect", 2015 IEEE MAGNETICS CONFERENCE (INTERMAG), IEEE, 11 May 2015 (2015-05-11), pages 1, XP033173781, [retrieved on 20150714], DOI: 10.1109/INTMAG.2015.7156565
ref_type: npl
severity: background
ref_id: US2010221351
ref_type: patent
severity: background
ref_id: WO2012166796
ref_type: patent
severity: obviousness
ref_id: WO2016203121
ref_type: patent
severity: obviousness
ref_id: - KIM J-E ET AL, "Thermally responsive nanocapsules with independent dual drug release profiles for combined cryotherapy of osteoarthritis", OSTEOARTHRITIS AND CARTILAGE, (2016), vol. 24, doi:10.1016/J.JOCA.2016.01.702, ISSN 1063-4584, XP029467355 [A] 1-14 * abstract *
ref_type: npl
severity: background
ref_id: - RAMA BHARGAVA ET AL, "Study of bioheat transfer phase change during cryosurgery for an irregular tumor tissue using EFGM", ARXIV.ORG, CORNELL UNIVERSITY LIBRARY, 201 OLIN LIBRARY CORNELL UNIVERSITY ITHACA, NY 14853, (20171106), XP080835499 [A] 1-14 * abstract *
ref_type: npl
severity: background
ref_id: - WUJIE ZHANG ET AL, "Synthesis and Characterization of Thermally Responsive Pluronic F127-Chitosan Nanocapsules for Controlled Release and Intracellular Delivery of Small Molecules", ACS NANO, (20101123), vol. 4, no. 11, doi:10.1021/nn101617n, ISSN 1936-0851, pages 6747 - 6759, XP055658902 [A] 1-14 * abstract * * Discussion *
ref_type: npl
severity: background
ref_id: - DE-RUI DI ET AL, "A new nano-cryosurgical modality for tumor treatment using biodegradable MgO nanoparticles", NANOMEDICINE , NANOTECHNOLOGY , BIOLOGY AND MEDICINE, NL, (201211), vol. 8, no. 8, doi:10.1016/j.nano.2012.02.010, ISSN 1549-9634, pages 1233 - 1241, XP055736841 [Y] 1-14 * abstract; figures 1-2 * * Discussion * * page  1235 *
ref_type: npl
severity: obviousness
ref_id: - YAN ET AL, "Nanocryosurgery and its mechanisms for enhancing freezing efficiency of tumor tissues", NANOMEDICINE , NANOTECHNOLOGY , BIOLOGY AND MEDICINE, ELSEVIER, NL, (20071226), vol. 4, no. 1, doi:10.1016/J.NANO.2007.11.002, ISSN 1549-9634, pages 79 - 87, XP022512450 [Y] 1-14 * abstract; figure 1 *
ref_type: npl
severity: obviousness
ref_id: - RAO WEI ET AL, "11. Effective destruction of cancer stem cells by combing freezing and anticancer drug encapsulated in nanoparticles", CRYOBIOLOGY, (2013), vol. 66, no. 3, doi:10.1016/J.CRYOBIOL.2013.02.017, ISSN 0011-2240, page 345, XP028534123 [A] 1-14 * abstract *
ref_type: npl
severity: background
ref_id: - XIN ZHANG ET AL, "Two-phase flow and heat transfer in a self-developed MRI compatible LN2 cryoprobe and its experimental evaluation", INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, AMSTERDAM, NL, (20190312), vol. 136, doi:10.1016/j.ijheatmasstransfer.2019.03.052, ISSN 0017-9310, pages 709 - 718, XP055737329 [Y] 1-14 * the whole document *
ref_type: npl
severity: obviousness
Final disposition: pending (2020-12-09)