Patent application EP19172816A (EP), filed 2019-05-06
Publication number: EP3736303A1
Title: NOVEL CATALYZED SYNTHESIS OF BIODEGRADABLE POLYESTERS
Abstract: The invention relates to a catalytic process for preparing polyester by ring-opening polymerization of at least one substituted glycolide of formula (I) or copolymerization of at least one substituted glycolide of formula (I) with trimethyl carbonate and/or at least one lactone of formula (II), wherein a strontium(II) alkoxide Sr(OR<sup>3</sup>)<sub>2</sub>, is used as a catalyst.
IPC codes: A61K  47/    34            A I
A61L  27/    12            A I
A61L  27/    18            A I
A61L  31/    06            A I
C08G  63/    08            A I
C08G  63/    64            A I
C08G  63/    82            A I
Claims: number: 1
text: Catalytic process for preparing polyester by ring-opening polymerization of at least one substituted glycolide of formula (I)
number: 2
text: The process according to Claim 1,
number: 3
text: The process according to Claim 1 or 2,
number: 4
text: The process according to either of Claims 1 to 3,
number: 5
text: The process according to either of Claims 1 to 4,
number: 6
text: The process according to either of Claims 1 to 5,
number: 7
text: The process according to either of Claims 1 to 6,
number: 8
text: The process according to Claim 7,
number: 9
text: The process according to either of Claims 1 to 8,
number: 10
text: The process according to either of Claims 1 to 9,
number: 11
text: Polyester with a Sr content of 10 ppm to 1 % by weight, comprising ester units of formula (III) and optionally ester units of formula (IV) and/or of formula (V):
number: 12
text: Polyester with a Sr content of 10 ppm to 1 % by weight,
obtainable by a process according to either of Claims 1 to 10.
number: 13
text: Bio-resorbable surgical article such a filament, a rod, a stent or a prostheses, a suture, an implant for bone fixation, bone cement, a scaffold for tissue engineering, a component of controlled drug release system, an in vitro or in vivo cell culture media, a cell culture matrix, a bio-adherent mixture such as bio-glue, a dental or a facial implant, a tendon repair structure, an implant or medical device coating comprising the polyester according to either of Claims 11 or 12.
number: 14
text: Polyester according to either of Claims 11 or 12 for use in preparing a bio-resorbable pharmaceutical active ingredient containing dosage form suitable for controlled drug release systems in the human body or in an animal body.
number: 15
text: Polyester according to either of Claims 11 or 12 for use in preparing a bio-resorbable medical device or surgical article such a filament, a rod, a stent or a prostheses, a suture, an implant for bone fixation, bone cement, a scaffold for tissue engineering, an in vitro or in vivo cell culture media, a cell culture matrix, a bio-adherent mixture such as bio-glue, a dental or a facial implant, a tendon repair structure, an implant or medical device coating.
Office action: search_report, dated 2020-11-11
Rejection reasons: inventive_step_epc_56
Prior art cited: ref_id: CN105566615A
ref_type: patent
severity: background
ref_id: CN1831027A
ref_type: patent
severity: background
ref_id: - Z. TANG ET AL., J. OF POLYM. SCI. PART A: POLYM. CHEM., vol. 41, 2003, pages 1934 - 1941
ref_type: npl
severity: background
ref_id: - SHORR E; CARTER AC, BULL HOSP JT DIS, vol. 13, 1952, pages 59 - 66
ref_type: npl
severity: background
ref_id: - MAIMOUN L ET AL., BONE, vol. 46, 2010, pages 1436 - 1441
ref_type: npl
severity: background
ref_id: - LI Y, CLIN ORAL IMPLANTS RES, vol. 23, 2012, pages 1038 - 1044
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severity: background
ref_id: - CLINICAL NUTRITION, vol. 26, 2007, pages 193 - 207
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severity: background
ref_id: EP1908484A2
ref_type: patent
severity: background
ref_id: EP2253637A1
ref_type: patent
severity: background
ref_id: CN107022070A
ref_type: patent
severity: background
ref_id: [XAYI]     - ZHAOHUI TANG ET AL: "Strontium-based initiator system for ring-opening polymerization of cyclic esters", JOURNAL OF POLYMER SCIENCE PART A: POLYMER CHEMISTRY, 1 July 2003 (2003-07-01), pages 1934 - 1941, XP055633865, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/doi/full/10.1002/pola.10740> [retrieved on 20191018], DOI: 10.1002/pola.10740
ref_type: npl
severity: background
ref_id: EP1908484
ref_type: patent
severity: obviousness
ref_id: EP2253637
ref_type: patent
severity: background
ref_id: CN107022070
ref_type: patent
severity: background
ref_id: [XAYI]  - Zhaohui Tang ET AL, "Strontium-based initiator system for ring-opening polymerization of cyclic esters", Journal of Polymer Science Part A: Polymer Chemistry, doi:10.1002/pola.10740, (20030701), pages 1934 - 1941, URL: https://onlinelibrary.wiley.com/doi/full/10.1002/pola.10740, (20191018), XP055633865 [X] 11,12 * page  1935, column  right, line  10  - page  1938, column  right, line  20; figure 4; examples 7-11; table 2 * [A] 9,10 [Y] 13-15 [I] 1-8
ref_type: npl
severity: background
Final disposition: pending (2020-11-11)