Patent application EP17161215A (EP), filed 2017-03-15
Publication number: EP3246015A1
Title: LUBRICANT FORMULATIONS
Abstract: A composition for lubricant formulations is disclosed. The composition may include hypochlorite, dimethicone, and an emulsifier for improvement of lubricity. Methods of making and using the lubricant formulations are also disclosed.
IPC codes: A61K  33/    20            A I
A61K  47/    02            A I
A61K  47/    34            A I
A61K   8/    02            A I
A61K   9/    00            A I
Claims: number: 1
text: A lubricant, comprising:
number: 2
text: The lubricant of claim 1, further comprising a buffer, preferably wherein the buffer is sodium phosphate.
number: 3
text: The lubricant of claim 1, wherein the buffer is present in an amount of about 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 6%, 7%, 10%, or 15% w/v, preferably wherein the buffer is present in an amount of about 0.2% w/v.
number: 4
text: The lubricant of any one of claims 1-3, wherein the hypochlorite is present in an amount of about 50 to about 100 ppm, preferably wherein the hypochlorite is present in an amount of about 75 ppm.
number: 5
text: The lubricant of any one of claims 1-4, wherein the emulsifier is sodium magnesium silicate.
number: 6
text: The lubricant of any one of claims 1-5, wherein the emulsifier is present in an amount of about 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 6%, 7%, 10%, or 15% w/v, preferably wherein the emulsifier is present in an amount of about 3.25% w/v.
number: 7
text: The lubricant of any one of claims 1-6, wherein the silicone polymer is dimethicone.
number: 8
text: The lubricant of any one of claims 1-7, wherein the silicone polymer is present in an amount of about 0.5%, 1%, 5%, 10%, 15%, 20%, 30%, 40%, or 50% w/v, preferably wherein the silicone polymer is present in an amount of about 10% w/v.
number: 9
text: The lubricant of any one of claims 1-8, further comprising water.
number: 10
text: The lubricant of any one of claims 1-9, wherein the lubricant has an osmolality of about 10, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 65, 70, 80, 90, or 100 mOsm/kg, as measured by freezing point osmometry, preferably wherein the lubricant has an osmolality of about 22 mOsm/kg, as measured by freezing point osmometry, alternatively wherein the lubricant has an osmolality of about 54 mOsm/kg, as measured by freezing point osmometry.
number: 11
text: The lubricant of claim 2, wherein the hypochlorite is in an amount of about 75 ppm, wherein the emulsifier comprises sodium magnesium silicate in an amount of about 3.25% w/v, wherein the silicone polymer comprises dimethicone in an amount of about 10% w/v, wherein the buffer comprises sodium phosphate in an amount of about 0.2% w/v, and wherein the lubricant further comprises water in an amount of about 61.55% w/v.
number: 12
text: A lubricant, comprising:
number: 13
text: The lubricant of claim 12, wherein hypochlorite is present in an amount of about 75 ppm, sodium magnesium silicate is present in an amount of about 3.25% w/v, dimethicone is present in an amount of about 10% w/v, sodium phosphate is present in an amount of about 0.2% w/v, and wherein the lubricant further comprises water in an amount of about 61.55% w/v.
number: 14
text: Use of the lubricant of any one of claims 1-13 for increasing comfort or lubricity.
number: 15
text: A method of using a lubricant, comprising providing the lubricant of any one of claims 1-13 and applying the lubricant.
number: 16
text: A method of making the lubricant of any one of claims 1-13, comprising providing a hypochlorite solution and a silicone polymer and mixing the ingredients to form a lubricant.
Office action: search_report, dated 2017-11-22
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Final disposition: pending (2017-11-22)