Patent application EP17167718A (EP), filed 2017-04-24
Publication number: EP3238711A1
Title: BASE FOR SOLID DISPERSION, PRODUCTION METHOD FOR SOLID DISPERSION USING SAME, AND SOLID DISPERSION
Abstract: [Problem] To provide a base for solid dispersion which is excellent in drug release rate and has less coloration.  [Means for Solution] A base for solid dispersion, comprising a polyvinyl alcohol-based resin with a carboxylic acid metal salt content of 0.8% by weight or less.
IPC codes: A61K  47/    69            A I
A61K   9/    14            A I
Claims: number: 1
text: A base for solid dispersion, comprising a polyvinyl alcohol-based resin with a carboxylic acid metal salt content of 0.8% by weight or less.
number: 2
text: The base for solid dispersion according to claim 1, wherein a saponification degree of the polyvinyl alcohol-based resin is 80-95% by mole.
number: 3
text: The base for solid dispersion according to claim 1 or 2, wherein an average degree of polymerization of the polyvinyl alcohol-based resin is 200-2,500.
number: 4
text: A method for producing solid dispersion, comprising melt-kneading a mixture of the base for solid dispersion according to any one of claims 1 to 3 and a drug, and then cooling the mixture.
number: 5
text: Solid dispersion comprising the base for solid dispersion according to any one of claims 1 to 3 and a drug.
Office action: search_report, dated 2017-11-01
Rejection reasons: novelty_epc_54
inventive_step_epc_56
Prior art cited: ref_id: JP2010536848A
ref_type: patent
severity: background
ref_id: WO2008133102A1
ref_type: patent
severity: background
ref_id: WO0177107A1
ref_type: patent
severity: background
ref_id: WO0064894A1
ref_type: patent
severity: background
ref_id: - J. ANTIBIOTICS, vol. 38, 1985, pages 877 - 885
ref_type: npl
severity: background
ref_id: - CHEM. PHARM. BULL., vol. 38, 1990, pages 2792 - 2796
ref_type: npl
severity: background
ref_id: US3607812A
ref_type: patent
severity: background
ref_id: EP2140883A1
ref_type: patent
severity: background
ref_id: - LAFOUNTAINE JUSTIN S ET AL: "Enabling thermal processing of ritonavir-polyvinyl alcohol amorphous solid dispersions by KinetiSol  Dispersing", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 101, 6 February 2016 (2016-02-06), pages 72 - 81, XP029459763, ISSN: 0939-6411, DOI: 10.1016/J.EJPB.2016.01.018
ref_type: npl
severity: background
ref_id: US3607812
ref_type: patent
severity: novelty_destroying
ref_id: EP2140883
ref_type: patent
severity: obviousness
ref_id: - LAFOUNTAINE JUSTIN S ET AL, "Enabling thermal processing of ritonavir-polyvinyl alcohol amorphous solid dispersions by KinetiSol Dispersing", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, (20160206), vol. 101, doi:10.1016/J.EJPB.2016.01.018, ISSN 0939-6411, pages 72 - 81, XP029459763 [Y] 1-5 * the whole document *
ref_type: npl
severity: obviousness
Final disposition: pending (2017-11-01)