Patent application EP17171705A (EP), filed 2017-05-18
Publication number: EP3246445A1
Title: LIPOXIN A4 DELIVERY SYSTEM BY A POROUS ELECTROSPUN POLYMERIC MEMBRANE
Abstract: A delivery system for lipoxin of LXA 4 , consisting of a polymeric porous matrix consisting of nanofibers of poly(ethylene oxide) (PEO) and poly(D,L-lactide) (PDLLA) obtained by electrospinning and it use for the treatment of periodontal diseases are disclosed.
IPC codes: A61K  31/   202            A I
A61K   9/    70            A I
D04H   1/   728            A I
Claims: number: 1
text: Delivery system comprising a porous membrane consisting of fibers of polyoxyethylene (POE) and poly-DL-lactide (PDLLA) and LXA<4> wherein the fibers of polyoxyethylene (POE) and poly-DL-lactide (PDLLA) are random oriented and have a diameter comprised between 0,8 and 1,2 µm, in the in porous membrane the pore size in comprised between 5 and 15 µm, the porous membrane have a glass-transition temperature (Tg) comprised between 45 and 50 °C, the porous membrane have a melting peak comprised between 59 and 64 °C.
number: 2
text: Delivery system according to claim 1 wherein the fibers of polyoxyethylene (POE) and poly-DL-lactide (PDLLA) have a diameter of 1µ.
number: 3
text: Delivery system according to claim 1 wherein in the porous membrane the pore size is 15 µm.
number: 4
text: Delivery system according to claim 1 wherein the porous membrane have a glass-transition temperature (Tg) of 47°C.
number: 5
text: Delivery system according to anyone of the claims from 1 to 4 for use as a medicament.
number: 6
text: Delivery system according to anyone of the claims from 1 to 4 for the treatment of periodontal diseases.
number: 7
text: Use according to claim 5 wherein periodontal disease is gingivitis or periodontitis or pyorrhea.
number: 8
text: Electrospinning process for the preparation of the delivery system of claim 1 comprising the following steps:
number: 9
text: Delivery system comprising a porous membrane consisting of fibers of polyoxyethylene (POE) and poly-DL-lactide (PDLLA) and LXA4 wherein the fibers of polyoxyethylene (POE) and poly-DL-lactide (PDLLA) are random oriented and have a diameter comprised between 0,8 and 1,2 µm, in the in porous membrane the pore size in comprised between 5 and 15 µm, the porous membrane have a glass-transition temperature (Tg) comprised between 45 and 50 °C, the porous membrane have a melting peak comprised between 59 and 64 °C obtained by an electrospinning process comprising the following steps:
Office action: search_report, dated 2017-11-22
Rejection reasons: inventive_step_epc_56
Prior art cited: ref_id: WO2014130068A1
ref_type: patent
severity: background
ref_id: US2015030688A1
ref_type: patent
severity: background
ref_id: - BOTTINO M C ET AL: "A novel spatially designed and functionally graded electrospun membrane for periodontal regeneration", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 7, no. 1, 27 August 2010 (2010-08-27), pages 216 - 224, XP027448763, ISSN: 1742-7061, [retrieved on 20100827], DOI: 10.1016/J.ACTBIO.2010.08.019
ref_type: npl
severity: background
ref_id: - SHI RUI ET AL: "Structure, physical properties, biocompatibility andin vitro/vivodegradation behavior of anti-infective polycaprolactone-based electrospun membranes for guided tissue/bone regeneration", POLYMER DEGRADATION AND STABILITY, BARKING, GB, vol. 109, 28 July 2014 (2014-07-28), pages 293 - 306, XP029093499, ISSN: 0141-3910, DOI: 10.1016/J.POLYMDEGRADSTAB.2014.07.017
ref_type: npl
severity: background
ref_id: - SAVVA I ET AL: "Fabrication, characterization, and evaluation in drug release properties of magnetoactive poly(ethylene oxide)-poly(l -lactide) electrospun membranes", BIOMACROMOLECULES 20131209 AMERICAN CHEMICAL SOCIETY USA, vol. 14, no. 12, 9 December 2013 (2013-12-09), pages 4436 - 4446, XP002765264, ISSN: 1525-7797
ref_type: npl
severity: background
ref_id: WO2014130068
ref_type: patent
severity: obviousness
ref_id: US2015030688
ref_type: patent
severity: obviousness
ref_id: - BOTTINO M C ET AL, "A novel spatially designed and functionally graded electrospun membrane for periodontal regeneration", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 7, no. 1, doi:10.1016/J.ACTBIO.2010.08.019, ISSN 1742-7061, (20100827), pages 216 - 224, (20100827), XP027448763 [Y] 1-9 * the whole document *
ref_type: npl
severity: obviousness
ref_id: - SHI RUI ET AL, "Structure, physical properties, biocompatibility andin vitro/vivodegradation behavior of anti-infective polycaprolactone-based electrospun membranes for guided tissue/bone regeneration", POLYMER DEGRADATION AND STABILITY, BARKING, GB, (20140728), vol. 109, doi:10.1016/J.POLYMDEGRADSTAB.2014.07.017, ISSN 0141-3910, pages 293 - 306, XP029093499 [Y] 1-9 * the whole document *
ref_type: npl
severity: obviousness
ref_id: - SAVVA I ET AL, "Fabrication, characterization, and evaluation in drug release properties of magnetoactive poly(ethylene oxide)-poly(l -lactide) electrospun membranes", BIOMACROMOLECULES 20131209 AMERICAN CHEMICAL SOCIETY USA, (20131209), vol. 14, no. 12, ISSN 1525-7797, pages 4436 - 4446, XP002765264 [YD] 1-9 * the whole document *
ref_type: npl
severity: obviousness
Final disposition: pending (2017-11-22)