Patent application EP16188915A (EP), filed 2016-09-15
Publication number: EP3144012A1
Title: ORAL SUPPLEMENT
Abstract: An oral supplement is provided comprising hyaluronic acid, probiotics, and xanthan gum.
IPC codes: A61K  31/   122            A I
A61K  31/   593            A I
A61K  31/   728            A I
A61K  39/    07            A I
A61K   9/    00            A I
Claims: number: 1
text: Oral supplementcharacterized by comprising:
number: 2
text: Oral supplement according to claim 1, wherein said hyaluronic acid has a low molecular weight.
number: 3
text: Oral supplement according to claim 1, wherein the content of said hyaluronic acid is substantially between 1% and 3%.
number: 4
text: Oral supplement according to claim 1, wherein said probiotics comprise Lactobacillaceae salivarius.
number: 5
text: Oral supplement according to claim 4, wherein the content of said Lactobacillaceae salivarius is substantially between 1% and 2%.
number: 6
text: Oral supplement according to claim 1, wherein the content of said Xanthan gum is substantially between 10% and 15%.
number: 7
text: Oral supplement according to claim 1, comprising at least one vitamin chosen from at least one out of vitamin C, vitamin D3 and vitamin K2.
number: 8
text: Oral supplement according to claim 7, comprising a plurality of said at least one vitamin and wherein said vitamins comprise said vitamin C, said vitamin D3 and said vitamin K2.
number: 9
text: Oral supplement according to claim 8, wherein the content of said vitamin C is substantially between 2% and 4%; wherein the content of said vitamin D3 is substantially between 0.01% and 0.15%; and wherein the content of said vitamin K2 is substantially between 0.5% and 1.5%.
number: 10
text: Oral supplement according to claim 1, wherein said content of said hyaluronic acid content is substantially equal to 2%; wherein said content of said Lactobacillaceae salivarius is substantially equal to 1.32%; wherein said content of said Xanthan gum is substantially equal to 12%; wherein said content of said vitamin C is substantially equal to 3.2%; wherein said content of said vitamin D3 is substantially equal to 0.09%; and wherein said content of said vitamin K2 is substantially equal to 0.75%.
Office action: search_report, dated 2017-03-22
Rejection reasons: inventive_step_epc_56
Prior art cited: ref_id: US2011318281A1
ref_type: patent
severity: background
ref_id: EP1908457A1
ref_type: patent
severity: background
ref_id: WO2005000321A1
ref_type: patent
severity: background
ref_id: - NOLAN A ET AL: "The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration", JOURNAL OF ORAL PATHOLOGY AND MEDICINE, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, vol. 35, no. 8, 1 January 2006 (2006-01-01), pages 461 - 465, XP007918028, ISSN: 0904-2512, [retrieved on 20060807]
ref_type: npl
severity: background
ref_id: - RICEFARMA S R L: "Gengigel/Hyalugel - A new preparation containing biotechnologically produced-Hyaluronic acid-For the dental management of gingivitis and periodontitis", no. ED.1, 22 September 2004 (2004-09-22), pages 1 - 17, XP003011484, Retrieved from the Internet <URL:http://web.archive.org/web/20040922084058/http://www.medis.si/ASPDatoteka.asp?ID =140> [retrieved on 20040922]
ref_type: npl
severity: background
ref_id: - KRASSE PER ET AL: "Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus reuteri", SWEDISH DENTAL JOURNAL, SN, STOCKHOLM, SE, vol. 30, no. 2, 1 January 2006 (2006-01-01), pages 55 - 60, XP008127657, ISSN: 0347-9994
ref_type: npl
severity: background
ref_id: - "Vitamin=C contg. tooth-paste for buccal dental hygiene - used for treating para-dental complaints, buccal lesions, gingivitis and stomatitis", DERWENT, 1993, XP002335549
ref_type: npl
severity: background
ref_id: - ARAL KUBRA ET AL: "Therapeutic Effects of Systemic Vitamin K2 and Vitamin D3 on Gingival Inflammation and Alveolar Bone in Rats With Experimentally Induced Periodontitis", JOURNAL OF PERIODONTOLOGY,, vol. 86, no. 5, 1 May 2015 (2015-05-01), pages 666 - 673, XP009188637, ISSN: 0022-3492, DOI: 10.1902/JOP.2015.140467
ref_type: npl
severity: background
ref_id: - "Vitamins and recurrent aphthous stomatitis", DENTAL ABSTRACTS, MOSBY, ST. LOUIS, MO, US, vol. 55, no. 5, 1 September 2010 (2010-09-01), pages 272 - 273, XP027255940, ISSN: 0011-8486, [retrieved on 20100904]
ref_type: npl
severity: background
ref_id: - VERMA ASHISH ET AL: "Effect of insertion of xanthan-based chlorhexidine gel in the maintenance phase following the treatment of chronic periodontitis", JOURNAL OF THE INDIAN SOCIETY OF PERIODONTOLOGY :,, vol. 16, no. 3, 1 July 2012 (2012-07-01), pages 381 - 385, XP009192758, ISSN: 0975-1580
ref_type: npl
severity: background
ref_id: - CHAUHAN AVINASH SINGH ET AL: "Comparative analysis of hyaluronan gel and xanthan-based chlorhexidine gel, as adjunct to scaling and root planing with scaling and root planing alone in the treatment of chronic periodontitis: A preliminary study", CONTEMPORARY CLINICAL DENTI,, vol. 4, no. 1, 1 January 2013 (2013-01-01), pages 54 - 61, XP009192757
ref_type: npl
severity: background
ref_id: WO2005000321
ref_type: patent
severity: obviousness
ref_id: EP1908457
ref_type: patent
severity: obviousness
ref_id: US2011318281
ref_type: patent
severity: obviousness
ref_id: - NOLAN A ET AL, "The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration", JOURNAL OF ORAL PATHOLOGY AND MEDICINE, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, vol. 35, no. 8, ISSN 0904-2512, (20060101), pages 461 - 465, (20060807), XP007918028 [Y] 1-10 * the whole document *
ref_type: npl
severity: obviousness
ref_id: - RICEFARMA S R L, "Gengigel/Hyalugel - A new preparation containing biotechnologically produced-Hyaluronic acid-For the dental management of gingivitis and periodontitis", no. ED.1, (20040922), pages 1 - 17, ANNOUNCEMENT GENGIGEL, XX, XX, URL: http://web.archive.org/web/20040922084058/http://www.medis.si/ASPDatoteka.asp?ID =140, (20040922), XP003011484 [Y] 1-10 * page  3, paragraph  9 * * page  4, paragraph  5 * * page  11, paragraph  1 *
ref_type: npl
severity: obviousness
ref_id: - KRASSE PER ET AL, "Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus reuteri", SWEDISH DENTAL JOURNAL, SN, STOCKHOLM, SE, (20060101), vol. 30, no. 2, ISSN 0347-9994, pages 55 - 60, XP008127657 [Y] 1-10 * the whole document *
ref_type: npl
severity: obviousness
ref_id: - "Vitamin=C contg. tooth-paste for buccal dental hygiene - used for treating para-dental complaints, buccal lesions, gingivitis and stomatitis", DERWENT, (1993), XP002335549 [Y] 1-10 * abstract *
ref_type: npl
severity: obviousness
ref_id: - ARAL KUBRA ET AL, "Therapeutic Effects of Systemic Vitamin K2 and Vitamin D3 on Gingival Inflammation and Alveolar Bone in Rats With Experimentally Induced Periodontitis", JOURNAL OF PERIODONTOLOGY,, (20150501), vol. 86, no. 5, doi:10.1902/JOP.2015.140467, ISSN 0022-3492, pages 666 - 673, XP009188637 [Y] 1-10 * the whole document *
ref_type: npl
severity: obviousness
ref_id: - "Vitamins and recurrent aphthous stomatitis", DENTAL ABSTRACTS, MOSBY, ST. LOUIS, MO, US, vol. 55, no. 5, ISSN 0011-8486, (20100901), pages 272 - 273, (20100904), XP027255940 [Y] 1-10 * the whole document *
ref_type: npl
severity: obviousness
ref_id: - VERMA ASHISH ET AL, "Effect of insertion of xanthan-based chlorhexidine gel in the maintenance phase following the treatment of chronic periodontitis", JOURNAL OF THE INDIAN SOCIETY OF PERIODONTOLOGY :,, (20120701), vol. 16, no. 3, ISSN 0975-1580, pages 381 - 385, XP009192758 [Y] 1-10 * the whole document *
ref_type: npl
severity: obviousness
ref_id: - CHAUHAN AVINASH SINGH ET AL, "Comparative analysis of hyaluronan gel and xanthan-based chlorhexidine gel, as adjunct to scaling and root planing with scaling and root planing alone in the treatment of chronic periodontitis: A preliminary study", CONTEMPORARY CLINICAL DENTI,, (20130101), vol. 4, no. 1, pages 54 - 61, XP009192757 [Y] 1-10 * the whole document *
ref_type: npl
severity: obviousness
Final disposition: pending (2017-03-22)