Patent application EP16173745A (EP), filed 2016-06-09
Publication number: EP3254732A1
Title: IMMUNOPOTENTIATING COMPOSITIONS COMPRISING AN ANTI HELICOBACTER PYLORI ANTIBODY
Abstract: The present invention provides a method for blocking immunosuppressive functions of pathogens, comprising: applying to an environment where the pathogens exist a composition that blocks immunosuppressive functions of the pathogens. The immunosuppressive functions are provided by an immunosuppressive substance secreted or produced by the pathogens. The composition includes a function inhibitor that comprises an antibody identifying the immunosuppressive substance or a fragment thereof. Use of the function inhibitor composition is also disclosed.
IPC codes: A61K  39/    00            A I
A61P   1/    04            A I
C07K  16/    12            A I
Claims: number: 1
text: A method for increasing immunity of a living body, comprising the step of applying directly or indirectly to a bacterial pathogen colonized internally or externally to the living body a composition that blocks an immunosuppressive function of the pathogen.
number: 2
text: The method according to claim 1, wherein the composition is applied to an internal of the living body colonized by the pathogen.
number: 3
text: The method according to claim 1, wherein the bacterial pathogen is one selected from the group consisted ofH. pylori, Arcobacter suis, Tannerella forsythia, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans andHelicobacter felis.
number: 4
text: The method according to claim 1, wherein the immunosuppressive function of the bacterial pathogens is provided by an immunosuppressive substance secreted or produced by the pathogen and the composition blocking the immunosuppressive function of pathogen comprises a function inhibitor that blocks functions of the immunosuppressive substance.
number: 5
text: The method according to claim 4, wherein the immunosuppressive substance secreted or produced by the pathogen comprises a heat shock protein or a fragment thereof.
number: 6
text: The method according to claim 5, wherein the heat shock protein comprises heat shock protein 60 or a fragment thereof.
number: 7
text: The method according to claim 6, wherein the heat shock protein 60 comprises a sequence of Sequence No. 1.
number: 8
text: The method according to claim 4, wherein the function inhibitor comprises a chemical or an antibody that identifies the immunosuppressive substance or a fragment thereof.
number: 9
text: The method according to claim 4, wherein the function inhibitor comprises a humanized product of an antibody that identifies the immunosuppressive substance or a fragment thereof.
number: 10
text: The method according to claim 5, wherein the function inhibitor comprises an antibody that identifies the heat shock protein or a fragment thereof.
number: 11
text: The method according to claim 10, wherein the function inhibitor comprises an antibody naturally generated by an immune response of the living body to the heat shock protein or a fragment thereof.
number: 12
text: The method according to claim 4, wherein the composition comprises an effective dose of the immunosuppressive substance and its pharmaceutically acceptable carrier or diluents.
number: 13
text: The method according to claim 12, wherein the composition further comprises an adjuvant that increases immunestimulating effects.
number: 14
text: Use of the functional inhibitor according to any of claims 8-11 in the preparation of a pharmaceutical that stimulates or enhances immune response against the pathogen.
number: 15
text: Use of the functional inhibitor according to any of claims 8-11 in the preparation of a pharmaceutical that heals or prevents a disease or symptom related to an existence or abnormal expression of the pathogen.
Office action: search_report, dated 2017-12-13
Rejection reasons: novelty_epc_54
inventive_step_epc_56
Prior art cited: ref_id: US6403099B1
ref_type: patent
severity: background
ref_id: - KAO J Y ET AL: "Helicobacter pylori Immune Escape Is Mediated by Dendritic CellInduced Treg Skewing and Th17 Suppression in Mice", GASTROENTEROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 138, no. 3, 1 March 2010 (2010-03-01), pages 1046 - 1054, XP026927461, ISSN: 0016-5085, [retrieved on 20091118], DOI: 10.1053/J.GASTRO.2009.11.043
ref_type: npl
severity: background
ref_id: - MIN ZHANG ET AL: "Helicobacter pylori-Pulsed Dendritic Cells Induce H. pylori-Specific Immunity in Mice", HELICOBACTER, vol. 13, no. 3, 6 June 2008 (2008-06-06), US, pages 200 - 208, XP055291850, ISSN: 1083-4389, DOI: 10.1111/j.1523-5378.2008.00606.x
ref_type: npl
severity: background
ref_id: - HSU WEI-TUNG: "Helicobacter pylori-derived heat shock protein 60 increases the induction of regulatory T cells (P3365)", THE JOURNAL OF IMMUNOLOGY, 1 May 2013 (2013-05-01), XP055291633, Retrieved from the Internet <URL:http://www.jimmunol.org/content/190/1_Supplement/202.5.short> [retrieved on 20160727]
ref_type: npl
severity: background
ref_id: - KUANG-WEN LIAO ET AL: "Antibodies againstheat shock protein 60 aggravate HSP60-mediated proinflammatory responses", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 55, no. 2, 15 April 2011 (2011-04-15), pages 174 - 180, XP028234142, ISSN: 1043-4666, [retrieved on 20110422], DOI: 10.1016/J.CYTO.2011.04.011
ref_type: npl
severity: background
ref_id: - KAO J Y ET AL, "Helicobacter pylori Immune Escape Is Mediated by Dendritic CellInduced Treg Skewing and Th17 Suppression in Mice", GASTROENTEROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 138, no. 3, doi:10.1053/J.GASTRO.2009.11.043, ISSN 0016-5085, (20100301), pages 1046 - 1054, (20091118), XP026927461 [X] 1-8 * figure 6E * [Y] 9-15
ref_type: npl
severity: novelty_destroying
ref_id: - MIN ZHANG ET AL, "Helicobacter pylori-Pulsed Dendritic Cells Induce H. pylori-Specific Immunity in Mice", HELICOBACTER, US, (20080606), vol. 13, no. 3, doi:10.1111/j.1523-5378.2008.00606.x, ISSN 1083-4389, pages 200 - 208, XP055291850 [X] 1-8 * figure 5 * [Y] 9-15
ref_type: npl
severity: novelty_destroying
ref_id: - Hsu Wei-Tung, "Helicobacter pylori-derived heat shock protein 60 increases the induction of regulatory T cells (P3365)", The Journal of Immunology, (20130501), URL: http://www.jimmunol.org/content/190/1_Supplement/202.5.short, (20160727), XP055291633 [Y] 9-15 * the whole document * [A] 1-8
ref_type: npl
severity: obviousness
ref_id: - KUANG-WEN LIAO ET AL, "Antibodies againstheat shock protein 60 aggravate HSP60-mediated proinflammatory responses", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 55, no. 2, doi:10.1016/J.CYTO.2011.04.011, ISSN 1043-4666, (20110415), pages 174 - 180, (20110422), XP028234142 [A] 1-15 * the whole document *
ref_type: npl
severity: background
Final disposition: pending (2017-12-13)