Patent application EP16175349A (EP), filed 2016-06-20
Publication number: EP3259990A1
Title: METHODS FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS
Abstract: The present invention relates to novel methods of treatment in the field of veterinary medicine, particularly methods for controlling ectoparasites in non-human mammals.
IPC codes: A01N  33/    04            A I
A01P   5/    00            A I
A01P   7/    02            A I
A01P   7/    04            A I
A61K   9/    00            A I
Claims: number: 1
text: A use of a veterinary shampoo composition comprising a compound selected from the group of a sphingoid base, a sphingoid base derivative or a mixture of two or more of these compounds, for applying it on non-human mammal during a topical treatment for controlling ectoparasites.
number: 2
text: The use according to claim 1, wherein the sphingoid base is selected from the group of sphingosin, sphinganin and phytosphingosine, and is preferably phytosphingosine.
number: 3
text: The use according to claim 1, wherein the sphingoid base derivative is selected from the group of N-lactyloyl-phytosphingosine, N-salicyloyl-phytosphingosine, or N-retinoylphytosphingosine.
number: 4
text: The use to any one of claims 1 to 3, wherein the concentration of sphingoid base compound is preferably between 0.001 and 20% by weight based on the total weight of the composition.
number: 5
text: The use according to any one of claims 1 to 4, wherein the shampoo composition contains surfactants, preferably at least one anionic, cationic, amphoteric, polar non-ionic surface active agent, or a mixture thereof.
number: 6
text: The use according to any one of claims 1 to 5, wherein the shampoo further comprises active ingredients, preferably at least one disinfectant, and more preferably chlorhexidine.
number: 7
text: The use according to any one of claims 1 to 6, wherein the topical treatment for controlling ectoparasites is a topical treatment against fleas and/or ticks.
number: 8
text: The use according to any one of claims 1 to 6, wherein the topical treatment for controlling ectoparasites is a topical treatment using at least one neonicotinoid compound, such as dinotefuran, N-arylpyrazole compound, such as fipronil, or Insect Growth Regulator (IGR), such as pyriproxyfen, chitin inhibitor, macrocyclic lactone, organochlorine or organophosphorus compound, carbamate compound, pyrethroid compound, such as permethrin, semicarbazone compound, anthelmintic compound, benzimidazole and imidazothiazole; synergists compounds, or a mixture thereof.
number: 9
text: The use according to any one of claims 1 to 8, wherein the non-human mammal is a dog or a cat.
number: 10
text: The use according to any one of claims 1 to 9, wherein the veterinary shampoo is topically applied onto a non-human mammal and rinsed thereafter, within a period of time ranging from 2 days before and 2 days after a topical treatment for controlling ectoparasites, preferably from 1 day before and 2 days after a topical treatment for controlling ectoparasites.
number: 11
text: The use according to any one of claims 1 to 10, wherein the veterinary shampoo is topically applied onto a non-human mammal and rinsed thereafter the same day of the topical treatment for controlling ectoparasites or one or two days after starting the topical treatment for controlling ectoparasites.
number: 12
text: A method for controlling ectoparasites in a non-human mammal comprising topically administering to said non-human mammal a veterinary composition comprising an effective amount of one or several active ingredients as insecticides, in combination with a simultaneous or sequential topical administration and rinse of a veterinary shampoo composition as defined herein comprising a compound selected from the group of a sphingoid base, a sphingoid base derivative or a mixture of two or more of these compounds.
number: 13
text: The method according to claim 12, wherein the shampoo is used within a period of time ranging from 2 days before and 2 days after a topical treatment for controlling ectoparasites, preferably from 1 day before and 2 days after a topical treatment for controlling ectoparasites.
number: 14
text: The method according to claim 12 or 13, wherein the veterinary shampoo is used the same day of the topical treatment for controlling ectoparasites or one or two days after the topical treatment for controlling ectoparasites.
number: 15
text: A kit comprising (a) one compartment comprising one or several active ingredients as insecticides and (b) a second compartment comprising a shampoo composition comprising a compound selected from the group of a sphingoid base, a sphingoid base derivative or a mixture of two or more of these compounds, for simultaneous or sequential use, in particular for controlling ectoparasites in a non-human mammal.
Office action: search_report, dated 2017-12-27
Rejection reasons: novelty_epc_54
inventive_step_epc_56
Prior art cited: ref_id: EP0649845A1
ref_type: patent
severity: background
ref_id: EP0295117A1
ref_type: patent
severity: background
ref_id: WO2010126003A1
ref_type: patent
severity: background
ref_id: WO2015187966A1
ref_type: patent
severity: background
ref_id: - SIMON-DELSO ET AL.: "Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites", ENVIRON. SCI. POLLUT. RES., vol. 22, 2015, pages 5 - 34, XP035420452, DOI: doi:10.1007/s11356-014-3470-y
ref_type: npl
severity: background
ref_id: - FORD KA; CASIDA JE: "Unique and common metabolites of thiamethoxam, clothianidin, and dinotefuran in mice", CHEM. RES. TOXICOL., vol. 19, 2006, pages 1549 - 1556, XP008156616, DOI: doi:10.1021/tx0601859
ref_type: npl
severity: background
ref_id: - "Neonicotinoid metabolism: compounds, substituents, pathways, enzymes, organisms, and relevance", J. AGRIC. FOOD CHEM., vol. 59, 2011, pages 2923 - 2931
ref_type: npl
severity: background
ref_id: - FAO DINOTEFURAN, Retrieved from the Internet <URL:http://www.fao.org/fileadmin/templates/agphome/documents>
ref_type: npl
severity: background
ref_id: US2013190401A1
ref_type: patent
severity: background
ref_id: DE19841794A1
ref_type: patent
severity: background
ref_id: DE19643585A1
ref_type: patent
severity: background
ref_id: DE19602108A1
ref_type: patent
severity: background
ref_id: US2010278903A1
ref_type: patent
severity: background
ref_id: WO2008060878A2
ref_type: patent
severity: background
ref_id: US2008090913A1
ref_type: patent
severity: background
ref_id: US2013202648A1
ref_type: patent
severity: background
ref_id: - LAUER S A ET AL: "SPHINGOLIPID SYNTHESIS AS A TARGET FOR CHEMOTHERAPY AGAINST MALARIA PARASITES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 92, no. 20, 1 September 1995 (1995-09-01), pages 9181 - 9185, XP001172814, ISSN: 0027-8424, DOI: 10.1073/PNAS.92.20.9181
ref_type: npl
severity: background
ref_id: - DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ROJO, DAVID ET AL: "A Multiplatform metabolomic approach to the basis of antimonial action and resistance in Leishmania infantum", XP002759623, retrieved from STN Database accession no. 2015:1417502
ref_type: npl
severity: background
ref_id: - ROJO, DAVID ET AL: "A Multiplatform metabolomic approach to the basis of antimonial action and resistance in Leishmania infantum", PLOS ONE , 10(7), E0130675/1-E0130675/20 CODEN: POLNCL; ISSN: 1932-6203, 2015, DOI: 10.1371/JOURNAL.PONE.0130675 10.1371/JOURNAL.PONE.0130675
ref_type: npl
severity: background
ref_id: DE19602108
ref_type: patent
severity: novelty_destroying
ref_id: DE19643585
ref_type: patent
severity: novelty_destroying
ref_id: DE19841794
ref_type: patent
severity: novelty_destroying
ref_id: US2008090913
ref_type: patent
severity: novelty_destroying
ref_id: WO2008060878
ref_type: patent
severity: obviousness
ref_id: US2010278903
ref_type: patent
severity: obviousness
ref_id: US2013190401
ref_type: patent
severity: novelty_destroying
ref_id: US2013202648
ref_type: patent
severity: obviousness
ref_id: - LAUER S A ET AL, "SPHINGOLIPID SYNTHESIS AS A TARGET FOR CHEMOTHERAPY AGAINST MALARIA PARASITES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, (19950901), vol. 92, no. 20, doi:10.1073/PNAS.92.20.9181, ISSN 0027-8424, pages 9181 - 9185, XP001172814 [I] 1-15 * the whole document * [Y] 1-15
ref_type: npl
severity: obviousness
ref_id: - ROJO, DAVID ET AL, "A Multiplatform metabolomic approach to the basis of antimonial action and resistance in Leishmania infantum", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 2015:1417502, URL: STN, XP002759623 [I] 1-15 * abstract * [Y] 1-15
ref_type: npl
severity: obviousness
ref_id: [ ]     - ROJO, DAVID ET AL, "A Multiplatform metabolomic approach to the basis of antimonial action and resistance in Leishmania infantum", PLOS ONE , 10(7), E0130675/1-E0130675/20 CODEN: POLNCL; ISSN: 1932-6203, (2015), doi:10.1371/JOURNAL.PONE.0130675 10.1371/JOURNAL.PONE.0130675
ref_type: npl
severity: background
Final disposition: pending (2017-12-27)