Patent application EP16174634A (EP), filed 2016-06-15
Publication number: EP3257574A1
Title: METHOD FOR PRODUCING A PARTICLE-SHAPED MATERIAL
Abstract: The invention relates to a process for producing particles from a melt, to polyethylene glycol microparticles and their use in cosmetics and/or pharmaceuticals, as a laxative or as aid in tablet production or melt granulation.
IPC codes: A61K   9/    20            A I
B01J   2/    04            A I
Claims: number: 1
text: A process for producing particles from a melt comprising:
number: 2
text: The process according to claim 1, wherein the gas of the stream of gas in step b) has a temperature between -35 and -3 °C and the gas removed at the tower head has a temperature between -5 and 15 °C.
number: 3
text: The process according to claim 1 or claim 2, wherein the powder obtained at the tower cone and/or the powder obtained at the tower head are the product particles.
number: 4
text: The process according to any of the claims 1 to 3, wherein the melt distribution device is a spray dryer.
number: 5
text: The process according to any of the claims 1 to 4, wherein separator unit is a cyclone.
number: 6
text: The process according to any of the claims 1 to 5, wherein the melt is a polymer melt.
number: 7
text: The process according to any of the claims 1 to 6, wherein the stream of gas contains nitrogen.
number: 8
text: The process according to any of the claims 1 to 7, wherein the stream of gas in step b) has a temperature between -45 and 30 °C.
number: 9
text: The process according to any of the claims 1 to 8, whereby the powder at the tower cone has an average particle size distribution, whereby
B1.1 18 to 32 wt % has a particle size of less than 90 µm,
B1.2 45 to 65 wt % has a particles size in the range from 90 to 200 µm,
B1.3 13 to 26 wt % has a particle size in the range from 200 to 400 µm and
B1.4 the mean particle diameter d50 is 100 to 140 µm
or
B2.1 4 to 12 wt % has a particles size of less than 90 µm,
B2.2 25 to 42 wt % has a particle size in the range from 90 to 200 µm,
B2.3 40 to 57 wt % has a particle size in the range from 200 to 400 µm,
B2.4 5 to 17 wt % has a particle size in the range from 400 to 630 µm and
B2.5 the mean particle diameter d50 is 200 to 240 µm
or
B3.1 less than 5 wt % has a particle size of less than 90 µm,
B3.2 12 to 23 wt % has a particle size in the range from 90 to 200 µm,
B3.3 40 to 60 wt % has a particle size in the range from 200 to 400 µm,
B3.4 20 to 0 wt % has a particle size in the range from 400 to 630 µm and
B3.5 the mean particle diameter d50 is 260 to 300 µm.
number: 10
text: The process according to any of the claims 1 to 9, wherein the powder from step e) is mixed with the powder obtained at the tower cone.
number: 11
text: The process according to any of the claims 1 to 10, wherein the powder obtained at the tower cone and/or the powder obtained at the tower cone mixed with powder from step e) has a bulk density in the range from 500 to 700 kg/m<3> .
number: 12
text: Polyethylene glycol microparticles obtained by
number: 13
text: The polyethylene glycol microparticles according to claim 12, wherein the polyethylene glycol microparticles have an average particle size distribution, whereby
B1.1 18 to 32 wt % have a particle size of less than 90 µm,
B1.2 45 to 65 wt % have a particles size in the range from 90 to 200 µm,
B1.3 13 to 26 wt % have a particle size in the range from 200 to 400 µm and
B1.4 the mean particle diameter d50 is 100 to 140 µm
or
B2.1 4 to 12 wt % have a particles size of less than 90 µm,
B2.2 25 to 42 wt % have a particle size in the range from 90 to 200 µm,
B2.3 40 to 57 wt % have a particle size in the range from 200 to 400 µm,
B2.4 5 to 17 wt % have a particle size in the range from 400 to 630 µm and
B2.5 the mean particle diameter d50 is 200 to 240 µm
or
B3.1 less than 5 wt % have a particle size of less than 90 µm,
B3.2 12 to 23 wt % have a particle size in the range from 90 to 200 µm,
B3.3 40 to 60 wt % have a particle size in the range from 200 to 400 µm,
B3.4 20 to 0 wt % have a particle size in the range from 400 to 630 µm and
B3.5 the mean particle diameter d50 is 260 to 300 µm.
number: 14
text: Use of the polyethylene glycol microparticles according to claims 12 or 13 in cosmetics and/or pharmaceuticals.
number: 15
text: Use of the polyethylene glycol microparticles according to claims 12 or 13 as a laxative.
number: 16
text: Use of the polyethylene glycol microparticles according to claims 12 or 13 as aid in tablet production or melt granulation.
Office action: search_report, dated 2017-12-20
Rejection reasons: novelty_epc_54
Prior art cited: ref_id: DE102004004968A1
ref_type: patent
severity: background
ref_id: EP0945173A1
ref_type: patent
severity: background
ref_id: - SCHUBERT, H.: "Handbuch der mechanischen Verfahrenstechnik", vol. 2, 2002, WILEY VCH, pages: 883
ref_type: npl
severity: background
ref_id: - PERRY R. H.; GREEN D.: "Perry's Chemical Engineers' Handbook", 1984, MCGRAW-HILL BOOK CO., pages: 20 - 57
ref_type: npl
severity: background
ref_id: - MARSHALL W. R.: "Atomization and Spray Drying", CHEM. ENG. PROG. MONOGR. SERIES, vol. 2, 1954, pages 50
ref_type: npl
severity: background
ref_id: - "HORIBA Scientific, A Guidebook to Particle Size Analysis", 2014, pages: 6
ref_type: npl
severity: background
ref_id: US2013164354A1
ref_type: patent
severity: background
ref_id: EP1865925A1
ref_type: patent
severity: background
ref_id: US2003108602A1
ref_type: patent
severity: background
ref_id: US8361452B2
ref_type: patent
severity: background
ref_id: DE102004004968A1
ref_type: patent
severity: background
ref_id: US2003108602
ref_type: patent
severity: novelty_destroying
ref_id: DE102004004968
ref_type: patent
severity: novelty_destroying
ref_id: EP1865925
ref_type: patent
severity: novelty_destroying
ref_id: US8361452
ref_type: patent
severity: novelty_destroying
ref_id: US2013164354
ref_type: patent
severity: novelty_destroying
Final disposition: pending (2017-12-20)