Patent application EP16382136A (EP), filed 2016-03-23
Publication number: EP3222270A1
Title: COMPOSITIONS FOR MUCOSAL ADHESION AND USES THEREOF
Abstract: [0001]    The present invention relates to compositions which adhere to mucous membranes comprising a polyol, a swelling polymer selected from the group consisting of celluloses and a derivative thereof, an inorganic salt comprising divalent cations and a solid waxy surfactant. The invention also relates to the method of preparation of said compositions and uses thereof.
IPC codes: A61K  47/    02            A I
A61K  47/    10            A I
A61K  47/    38            A I
A61K   9/    00            A I
A61K   9/    06            A I
Claims: number: 1
text: A composition having a viscosity from 4 to 300 Pa.s comprising:
number: 2
text: The composition according to claim 1, wherein component (i) is selected from the group consisting of glycerol, propylene glycol and a combination thereof.
number: 3
text: The composition according to any one of claims 1 or 2, wherein component (ii) is selected from the group consisting of a salt of carboxymethyl cellulose (CMC), hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC) and a combination thereof.
number: 4
text: The composition according to any one of claims 1 to 3, wherein component (iii) is selected from the group consisting of CaSO<4> , CaCl<2> , MgCl<2> , CuSO<4> , and CaCO<3> .
number: 5
text: The composition according to any one of claims 1 to 4, wherein component (iv) is selected from the group consisting of glyceryl monostearate, sorbitan monostearate, cetostearyl alcohol and combinations thereof.
number: 6
text: The composition according to any one of claims 1 to 5, further comprising a compound selected from the group consisting of a thickener, a polysaccharide different from component (ii), a surfactant different from component (iv), an adhesive polymer, a fat, and a combination thereof.
number: 7
text: The composition according to any one of claims 1 to 6 comprising:
number: 8
text: The composition according to any one of claims 1 to 7, further comprising at least an active ingredient suitable for topical or oral use selected from the group consisting of antibiotics, antimycotics, enzymes, antiprotozoals, antivirals, anti-inflammatories, antihistamines, antiperiodontosis agents, antifungals, antibacterials, whitening agents, disinfectants, analgesics, anesthetics, wound healing agents, anti-nauseants, chemotherapeutics, immunosuppressive agents, immunomodulators, antiseptics, mucolytics, antitussives, decongestants, calcium absorption and regulating agents, hormones, vaccines, biological agents, personal care products, natural plant extracts, vitamins, omega 3- oils, amino acids, peptides and combinations thereof.
number: 9
text: The composition according to claim 8, wherein the active ingredient is selected from the group consisting of miconazole, carbenoxolone, dexamethasone, triamcinolone, lidocaine, clobetasol, dipotassium glycyrrhizate, dexpanthenol, allantoin, chlorhexidine digluconate and mixtures thereof.
number: 10
text: The composition according to any one of claims 1 to 9 for use as a medicament.
number: 11
text: The composition according to any one of claims 1 to 9 for use in the prevention and/or treatment of a disease selected from the group consisting of:
number: 12
text: Use of the composition according to any one of claims 1 to 8 as an adhesive for dentures.
number: 13
text: A method for the preparation of a composition according to any one of claims 1 to 9 comprising:
number: 14
text: The method according to claim 13, further comprising at least two additional steps between steps (a) and (b), said steps being:
number: 15
text: A method for obtaining a nanoparticle composition comprising contacting a composition according to any one of claims 1 to 9 that contains an adhesive polymer dissolved in compound (i), with an aqueous medium, wherein said adhesive polymer is selected from the group consisting of half esters of poly(methyl vinyl ether-co-maleic anhydride) (PVM/MA) copolymers, poly(methylvinyl ether/maleic acid), zein and polymethacrylates.
Office action: search_report, dated 2017-09-27
Prior art cited: ref_id: US4894232A
ref_type: patent
severity: background
ref_id: US2015017105A1
ref_type: patent
severity: background
ref_id: WO2013120856A1
ref_type: patent
severity: background
ref_id: WO2012140252A1
ref_type: patent
severity: background
ref_id: US6596777B1
ref_type: patent
severity: background
ref_id: EP0306454A2
ref_type: patent
severity: background
ref_id: US2014249118A1
ref_type: patent
severity: background
ref_id: WO2005027939A1
ref_type: patent
severity: background
ref_id: WO2013038402A1
ref_type: patent
severity: background
ref_id: WO9523591A1
ref_type: patent
severity: background
ref_id: EP0306454
ref_type: patent
severity: background
ref_id: WO9523591
ref_type: patent
severity: background
ref_id: US6596777
ref_type: patent
severity: background
ref_id: WO2005027939
ref_type: patent
severity: background
ref_id: WO2013038402
ref_type: patent
severity: background
ref_id: US2014249118
ref_type: patent
severity: background
Final disposition: pending (2017-09-27)