Patent application EP15847220A (EP), filed 2015-09-15
Publication number: EP3200825A1
Title: ANTIBODIES AGAINST PATHOLOGICAL FORMS OF TDP-43 AND USES THEREOF
IPC codes: A61K  39/   395            A I
C07K  16/    18            A I
G01N  33/    68            A I
Office action: search_report, dated 2017-08-09
Prior art cited: ref_id: EP2189526
ref_type: patent
severity: background
ref_id: - YU-SHENG FANG ET AL, "Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients", NATURE COMMUNICATIONS, (20140912), vol. 5, doi:10.1038/ncomms5824, page 4824, XP055447922 [I] 1-11 * the whole document *
ref_type: npl
severity: background
ref_id: - LINDA K KWONG ET AL, "Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins", ACTA NEUROPATHOLOGICA COMMUNICATIONS, BIOMED CENTRAL LTD, LONDON, UK, (20140331), vol. 2, no. 1, doi:10.1186/2051-5960-2-33, ISSN 2051-5960, page 33, XP021182567 [I] 1-11 * abstract * * table 1 *
ref_type: npl
severity: background
ref_id: - ZHANG H X ET AL, "Epitope mapping of 2E2-D3, a monoclonal antibody directed against human TDP-43", NEUROSCIENCE LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 434, no. 2, doi:10.1016/J.NEULET.2008.01.060, ISSN 0304-3940, (20080328), pages 170 - 174, (20080202), XP022594057 [I] 1-11 * abstract *
ref_type: npl
severity: background
ref_id: - HASEGAWA MASATO ET AL, "Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis", ANNALS OF NEUROL, JOHN WILEY AND SONS, BOSTON, US, (20080701), vol. 64, no. 1, ISSN 0364-5134, pages 60 - 70, XP009137602 [I] 1-11 * abstract *
ref_type: npl
severity: background
ref_id: - RUDIKOFF S ET AL, "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, (19820301), vol. 79, doi:10.1073/PNAS.79.6.1979, ISSN 0027-8424, pages 1979 - 1983, XP007901436 [A] 1-11 * the whole document *
ref_type: npl
severity: background
ref_id: - JOERY GOOSSENS ET AL, "TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies", ACTA NEUROPATHOLOGICA COMMUNICATIONS, BIOMED CENTRAL LTD, LONDON, UK, (20150401), vol. 3, no. 1, doi:10.1186/S40478-015-0195-1, ISSN 2051-5960, page 15, XP021219986 [IP] 1-11 * abstract * * table 1 * * table 2 *
ref_type: npl
severity: background
Final disposition: pending (2017-08-09)