Patent application EP15192002A (EP), filed 2015-10-29
Publication number: EP3184547A1
Title: ANTI-TPBG ANTIBODIES AND METHODS OF USE
Abstract: The invention provides anti-TPBG antibodies and methods of using the same.
IPC codes: A61K  39/    00            A I
A61K  49/    00            A I
C07K  16/    30            A I
Claims: number: 1
text: An isolated antibody that binds to trophoblast glycoprotein (TPBG), wherein the antibody binds to human TPBG (SEQ ID NO: 1) and to minipig TPBG (SEQ ID NO: 2) with a K<D> of 10<-8> M or less.
number: 2
text: The antibody of claim 1, wherein the antibody specifically binds to human TPBG at a pH of 5.5 and a pH of 7.4.
number: 3
text: The antibody of any one of claims 1 to 2, wherein the antibody comprises
number: 4
text: The antibody of claim of any one of claims 1 or 2, wherein the antibody comprises a CDR1 of the heavy chain of SEQ ID NO: 11, a CDR2 of the heavy chain of SEQ ID NO: 12, and a CDR3 of the heavy chain of SEQ ID NO: 13, a CDR1 of the light chain of SEQ ID NO: 14, a CDR2 of the light chain of SEQ ID NO: 15, and a CDR3 of the light chain of SEQ ID NO: 16.
number: 5
text: A humanized antibody that binds to TBPG derived from the antibody of claim 4.
number: 6
text: An antibody comprising either:
number: 7
text: A humanized antibody that binds to TPBG derived from the antibody of claim 7.
number: 8
text: An isolated nucleic acid encoding the antibody of any one of claims 1 to 7.
number: 9
text: A host cell comprising the nucleic acid of claim 8.
number: 10
text: A method of producing an antibody comprising culturing the host cell of claim 9 so that the antibody is produced.
number: 11
text: An immunoconjugate comprising the antibody of any one of claims 1 to 7 and a cytotoxic agent.
number: 12
text: A method of producing an immunoconjugate according claim 11, including the step of coupling the antibody to the cytotoxic agent.
number: 13
text: A recombinant fusion protein comprising an antibody of any one of claims 1 to 7 and any other polypeptide.
number: 14
text: A pharmaceutical formulation comprising the antibody of any one of claims 1 to 7, the immunoconjugate of claim 11, or the recombinant fusion protein of claim 13 and a pharmaceutically acceptable carrier.
number: 15
text: The antibody of any one of claims 1 to 7 for use as a medicament.
Office action: search_report, dated 2017-06-28
Rejection reasons: novelty_epc_54
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Final disposition: pending (2017-06-28)