Giải quần vợt Mỹ Mở rộng 2019 - Đôi nam nữ

Bethanie Mattek-Sands Jamie Murray
| runner = Chan Hao-ching Michael Venus
| score = 6–2, 6–3
| before_name= Giải quần vợt Mỹ Mở rộng – Đôi nam nữ
| after_name= Giải quần vợt Mỹ Mở rộng – Đôi nam nữ
}}

Bethanie Mattek-Sands và Jamie Murray là đương kim vô địch và bảo vệ thành công chức vô địch sau khi đánh bại Chan Hao-ching và Michael Venus tại chung kết với tỷ số 6–2, 6–3.

Hạt giống
Chan Hao-ching / Michael Venus
Gabriela Dabrowski / Mate Pavić (Tứ kết)
Samantha Stosur / Rajeev Ram
Latisha Chan / Ivan Dodig
Nicole Melichar / Bruno Soares (Vòng 2)
Demi Schuurs / Henri Kontinen (Tứ kết)
Anna-Lena Grönefeld / Oliver Marach (Vòng 1)
Květa Peschke / Wesley Koolhof (Tứ kết)
}}

Bốc thăm

Vòng chung kết
Chan Hao-ching Michael Venus
| RD1-score1-1=77
| RD1-score1-2=7
| RD1-score1-3=
| RD1-seed2=4
| RD1-team2= Latisha Chan Ivan Dodig
| RD1-score2-1=63
| RD1-score2-2=5
| RD1-score2-3=

| RD1-seed3=3
| RD1-team3= Samantha Stosur Rajeev Ram
| RD1-score3-1=3
| RD1-score3-2=1
| RD1-score3-3=
| RD1-seed4=WC
| RD1-team4= Bethanie Mattek-Sands Jamie Murray
| RD1-score4-1=6
| RD1-score4-2=6
| RD1-score4-3=

| RD2-seed1=1
| RD2-team1= Chan Hao-ching Michael Venus
| RD2-score1-1=2
| RD2-score1-2=3
| RD2-score1-3=
| RD2-seed2=WC
| RD2-team2= Bethanie Mattek-Sands Jamie Murray
| RD2-score2-1=6
| RD2-score2-2=6
| RD2-score2-3=
}}

Nửa trên
H-c Chan M Venus
| RD1-score01-1=77
| RD1-score01-2=77
| RD1-score01-3=
| RD1-seed02=
| RD1-team02= A Klepač K Skupski
| RD1-score02-1=64
| RD1-score02-2=65
| RD1-score02-3=

| RD1-seed03=
| RD1-team03= D Krawczyk J Salisbury
| RD1-score03-1=6
| RD1-score03-2=6
| RD1-score03-3=
| RD1-seed04=WC
| RD1-team04= H Baptiste J Brooksby
| RD1-score04-1=2
| RD1-score04-2=2
| RD1-score04-3=

| RD1-seed05=
| RD1-team05= Y Duan M Demoliner
| RD1-score05-1=79
| RD1-score05-2=6
| RD1-score05-3=
| RD1-seed06=
| RD1-team06= L Siegemund A Mies
| RD1-score06-1=67
| RD1-score06-2=4
| RD1-score06-3=

| RD1-seed07=WC
| RD1-team07= C McHale R Harrison
| RD1-score07-1=4
| RD1-score07-2=6
| RD1-score07-3=[11]
| RD1-seed08=8
| RD1-team08= K Peschke W Koolhof
| RD1-score08-1=6
| RD1-score08-2=3
| RD1-score08-3=[13]

| RD1-seed09=4
| RD1-team09= L Chan I Dodig
| RD1-score09-1=6
| RD1-score09-2=6
| RD1-score09-3=
| RD1-seed10=
| RD1-team10= MJ Martínez Sánchez N Skupski
| RD1-score10-1=4
| RD1-score10-2=3
| RD1-score10-3=

| RD1-seed11=
| RD1-team11= L Hradecká A Sitak
| RD1-score11-1=4
| RD1-score11-2=5
| RD1-score11-3=
| RD1-seed12=
| RD1-team12= R Olaru F Škugor
| RD1-score12-1=6
| RD1-score12-2=7
| RD1-score12-3=

| RD1-seed13=
| RD1-team13= A Rosolska N Mektić
| RD1-score13-1=3
| RD1-score13-2=2
| RD1-score13-3=
| RD1-seed14=
| RD1-team14= A Spears R Bopanna
| RD1-score14-1=6
| RD1-score14-2=6
| RD1-score14-3=

| RD1-seed15=
| RD1-team15= R Atawo F Martin
| RD1-score15-1=2
| RD1-score15-2=6
| RD1-score15-3=[10]
| RD1-seed16=7
| RD1-team16= A-L Grönefeld O Marach
| RD1-score16-1=6
| RD1-score16-2=4
| RD1-score16-3=[8]

| RD2-seed01=1
| RD2-team01= H-c Chan M Venus
| RD2-score01-1=6
| RD2-score01-2=6
| RD2-score01-3=
| RD2-seed02=
| RD2-team02= D Krawczyk J Salisbury
| RD2-score02-1=4
| RD2-score02-2=3
| RD2-score02-3=

| RD2-seed03=
| RD2-team03= Y Duan M Demoliner
| RD2-score03-1=5
| RD2-score03-2=6
| RD2-score03-3=[7]
| RD2-seed04=8
| RD2-team04= K Peschke W Koolhof
| RD2-score04-1=7
| RD2-score04-2=4
| RD2-score04-3=[10]

| RD2-seed05=4
| RD2-team05= L Chan I Dodig
| RD2-score05-1=6
| RD2-score05-2=6
| RD2-score05-3=
| RD2-seed06=
| RD2-team06= R Olaru F Škugor
| RD2-score06-1=1
| RD2-score06-2=1
| RD2-score06-3=

| RD2-seed07=
| RD2-team07= A Spears R Bopanna
| RD2-score07-1=5
| RD2-score07-2=64
| RD2-score07-3=
| RD2-seed08=
| RD2-team08= R Atawo F Martin
| RD2-score08-1=7
| RD2-score08-2=77
| RD2-score08-3=

| RD3-seed01=1
| RD3-team01= H-c Chan M Venus
| RD3-score01-1=6
| RD3-score01-2=77
| RD3-score01-3=
| RD3-seed02=8
| RD3-team02= K Peschke W Koolhof
| RD3-score02-1=3
| RD3-score02-2=60
| RD3-score02-3=

| RD3-seed03=4
| RD3-team03= L Chan I Dodig
| RD3-score03-1=77
| RD3-score03-2=3
| RD3-score03-3=[10]
| RD3-seed04=
| RD3-team04= R Atawo F Martin
| RD3-score04-1=63
| RD3-score04-2=6
| RD3-score04-3= [3]

| RD4-seed01=1
| RD4-team01= H-c Chan M Venus
| RD4-score01-1=77
| RD4-score01-2=
| RD4-score01-3=
| RD4-seed02=4
| RD4-team02= L Chan I Dodig
| RD4-score02-1=63
| RD4-score02-2=
| RD4-score02-3=
}}

Nửa dưới
D Schuurs H Kontinen
| RD1-score01-1=7
| RD1-score01-2=6
| RD1-score01-3=
| RD1-seed02=
| RD1-team02= A Muhammad A Krajicek
| RD1-score02-1=5
| RD1-score02-2=4
| RD1-score02-3=

| RD1-seed03=WC
| RD1-team03= J Brady D Kudla
| RD1-score03-1=711
| RD1-score03-2=6
| RD1-score03-3=
| RD1-seed04=
| RD1-team04= S Zheng J Vliegen
| RD1-score04-1=69
| RD1-score04-2=4
| RD1-score04-3=

| RD1-seed05=
| RD1-team05= K Flipkens É Roger-Vasselin
| RD1-score05-1=6
| RD1-score05-2=6
| RD1-score05-3=
| RD1-seed06=WC
| RD1-team06= C Vandeweghe M Cressy
| RD1-score06-1=2
| RD1-score06-2=4
| RD1-score06-3=

| RD1-seed07=WC
| RD1-team07= K Christian J Cerretani
| RD1-score07-1=4
| RD1-score07-2=5
| RD1-score07-3=
| RD1-seed08=3
| RD1-team08= S Stosur R Ram
| RD1-score08-1=6
| RD1-score08-2=7
| RD1-score08-3=

| RD1-seed09=5
| RD1-team09= N Melichar B Soares
| RD1-score09-1=6
| RD1-score09-2=6
| RD1-score09-3=
| RD1-seed10=
| RD1-team10= S-w Hsieh C-p Hsieh
| RD1-score10-1=1
| RD1-score10-2=4
| RD1-score10-3=

| RD1-seed11=WC
| RD1-team11= B Mattek-Sands J Murray
| RD1-score11-1=6
| RD1-score11-2=62
| RD1-score11-3=[10]
| RD1-seed12=
| RD1-team12= S Zhang J Peers
| RD1-score12-1=4
| RD1-score12-2=77
| RD1-score12-3=[7]

| RD1-seed13=WC
| RD1-team13= D Collins N Monroe
| RD1-score13-1=2
| RD1-score13-2=2
| RD1-score13-3=
| RD1-seed14=WC
| RD1-team14= H Carter J Withrow
| RD1-score14-1=6
| RD1-score14-2=6
| RD1-score14-3=

| RD1-seed15=Alt
| RD1-team15= D Jurak M Daniell
| RD1-score15-1=2
| RD1-score15-2=2
| RD1-score15-3=
| RD1-seed16=2
| RD1-team16= G Dabrowski M Pavić
| RD1-score16-1=6
| RD1-score16-2=6
| RD1-score16-3=

| RD2-seed01=6
| RD2-team01= D Schuurs H Kontinen
| RD2-score01-1=4
| RD2-score01-2=77
| RD2-score01-3=[10]
| RD2-seed02=WC
| RD2-team02= J Brady D Kudla
| RD2-score02-1=6
| RD2-score02-2=62
| RD2-score02-3=[8]

| RD2-seed03=
| RD2-team03= K Flipkens É Roger-Vasselin
| RD2-score03-1=62
| RD2-score03-2=5
| RD2-score03-3=
| RD2-seed04=3
| RD2-team04= S Stosur R Ram
| RD2-score04-1=77
| RD2-score04-2=7
| RD2-score04-3=

| RD2-seed05=5
| RD2-team05= N Melichar B Soares
| RD2-score05-1=3
| RD2-score05-2=3
| RD2-score05-3=
| RD2-seed06=WC
| RD2-team06= B Mattek-Sands J Murray
| RD2-score06-1=6
| RD2-score06-2=6
| RD2-score06-3=

| RD2-seed07=WC
| RD2-team07= H Carter J Withrow
| RD2-score07-1=66
| RD2-score07-2=2
| RD2-score07-3=
| RD2-seed08=2
| RD2-team08= G Dabrowski M Pavić
| RD2-score08-1=78
| RD2-score08-2=6
| RD2-score08-3=

| RD3-seed01=6
| RD3-team01= D Schuurs H Kontinen
| RD3-score01-1=6
| RD3-score01-2=4
| RD3-score01-3=[12]
| RD3-seed02=3
| RD3-team02= S Stosur R Ram
| RD3-score02-1=4
| RD3-score02-2=6
| RD3-score02-3=[14]

| RD3-seed03=WC
| RD3-team03= B Mattek-Sands J Murray
| RD3-score03-1=2
| RD3-score03-2=7
| RD3-score03-3=[10]
| RD3-seed04=2
| RD3-team04= G Dabrowski M Pavić
| RD3-score04-1=6
| RD3-score04-2=5
| RD3-score04-3=[4]

| RD4-seed01=3
| RD4-team01= S Stosur R Ram
| RD4-score01-1=3
| RD4-score01-2=1
| RD4-score01-3=
| RD4-seed02=WC
| RD4-team02= B Mattek-Sands J Murray
| RD4-score02-1=6
| RD4-score02-2=6
| RD4-score02-3=
}}

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