Metrifonate

Trichlorfon; Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl) dimethylphosphonate; Agroforotox; Anthon; Chlorofos; Chloroftalm; Chlorophos; Chlorophthalm; Chloroxyphos; Combot; Dimethyl (trichlorohydroxyethyl)phosphonate; Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; Dipterax; Dipterex; Dipterex 50; Diptevur; Ditrifon; Dylox; Dyrex; Dyvon; DEP; DEP (Pesticide); DETF; ENT 19,763; Flibol E; Fliegenteller; Forotox; Foschlor; Foschlor R; Foschlor R 50; Hypodermacid; Loisol; Masoten; Mazoten; Methyl Chlorophos; Metifonate; Metriphonate; Neguron; Neguvon; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; O,O-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; O,O-Dimethyl (2,2,2-trichlorohydroxyethyl)phosphonate; Phoschlor; Phoschlor R50; Polfoschlor; Ricifon; Ritsifon; Soldep; Sotipox; Trichlorphon; Trichlorphon FN; Tugon; Volfartol; Votexit; Wotexit; WEC 50; (1-Hydroxy-2,2,2-trichloroethyl)phosphonic acid, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl)phosphonate, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl)phosphonic acid dimethyl ester; Bayer L 1359; Bilarcil; Bovinox; Briton; BAY 15922; Cekufon; Chlorophosciclosom; Clorofos; Danex; Dimethoxy-(2,2,2-trichloro-1-hydroxyethyl)phosphine oxide; Equino-Aid; Foschlorem; Khloroftalm; NCI-C54831; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphate; O,O-Dimethyl-(1-hydroxy-2,2,2-trichloraethyl)phosphosaeure ester; O,O-Dimethyl-(1-hydroxy-2,2,2-trichlorathyl)-phosphat; O,O-Dimethyl-(2,2,2-trichloor-1-hydroxy-ethyl)-fosfonaat; O,O-Dimethyl-(2,2,2-trichlor-1-hydroxy-aethyl)phosphonat; O,O-Dimetil-(2,2,2-tricloro-1-idrossi-etil)-fosfonato; Phosphonic acid, (1-hydroxy-2,2,2-trichloroethyl)-, dimethyl ester; Proxol; Trichloorfon; Trichlorofon; Trichlorophon; Trinex; 1-Hydroxy-2,2,2-trichloro-ethyle phosphonate de dimethyle; Bay-L 1359; Briten; Denkaphon; Dipterex WP 80; Ertefon; OMS 800; Zeltivar; Onefon; O,O-Dimethyl-1-oxy-2,2,2-trichloroethyl phosphonate;Trichlorfon; 1-Hydroxy-2,2,2-trichloroethylphosphonate-O,O-dimethyl ester; Phosphonic acid, P-(2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; Chlorak; Dimetox; Dioxaphos
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| pregnancy_AU =
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| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life = 3 hours
| excretion =

| CAS_number_Ref =
| CAS_number = 52-68-6
| CAS_supplemental =
| ATC_prefix = P02
| ATC_suffix = BB01
| ATC_supplemental =
| PubChem = 5853
| DrugBank_Ref =
| DrugBank =
| UNII_Ref =
| UNII = DBF2DG4G2K
| KEGG_Ref =
| KEGG = C07971
| ChEBI_Ref =
| ChEBI = 6908
| synonyms = Trichlorphon
| ChemSpiderID_Ref =
| ChemSpiderID = 5644

| chemical_formula =
| C=4 | H=8 | Cl=3 | O=4 | P=1
| molecular_weight = 257.436 g/mol
| smiles = COP(=O)(C(C(Cl)(Cl)Cl)O)OC
| StdInChI_Ref =
| StdInChI = 1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3
| StdInChIKey_Ref =
| StdInChIKey = NFACJZMKEDPNKN-UHFFFAOYSA-N
}}

Metrifonate (INN) hay trichlorfon (USAN) là một organophosphate acetylcholinesterase inhibitor không thể đảo ngược. Nó là một prolek được kích hoạt không theo enzyme vào 2,2-dichlorovinyl dimethyl phosphate (DDVP).

Nó được sử dụng làm thuốc diệt côn trùng.

Nó có thể được sử dụng để điều trị schistosomiasis gây ra bởi Schistoma haematobium, nhưng không còn sẵn sàng về mặt thương mại.

Nó đã được kiến nghị sử dụng điều trị bệnh Alzheimer, nhưng việc sử dụng cho mục đích này hiện không được khuyến nghị.

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