Giải Tinh thần độc lập cho nữ diễn viên chính xuất sắc nhất

}}
Giải Tinh thần độc lập cho nữ diễn viên chính xuất sắc nhất là một trong các giải Tinh thần độc lập dành cho nữ diễn viên đóng vai chính trong một phim độc lập, được bầu chọn là xuất sắc nhất. Giải này được lập từ năm 1985.

Các người đoạt giải & được đề cử
Thập niên 1980
1985: Geraldine Page - The Trip to Bountiful
Rosanna Arquette - After Hours
Laura Dern - Smooth Talk
Lori Singer - Trouble in Mind
1986: Isabella Rossellini - Blue Velvet
Elpidia Carrillo - Salvador
Patricia Charbonneau - Desert Hearts
Laura Dern - Blue Velvet
Tracy Camilla Johns - She's Gotta Have It
1987: Isabella Rossellini - Blue Velvet
Laura Dern - Blue Velvet
Patricia Charbonneau - Desert Hearts
Elpidia Carrillo - Salvador
Tracy Camilla Johns - She's Gotta Have It
1988: Sally Kirkland - Anna
Joanne Woodward - The Glass Menagerie
Debra Sandlund - Tough Guys Don't Dance
Lillian Gish - The Whales of August
Louise Smith - Working Girls
1989: Jodie Foster - Five Corners
Ricki Lake - Hairspray
Julia Roberts - Mystic Pizza
Meg Ryan - Promised Land
Nobu McCarthy - The Wash

Thập niên 1990
1990: Andie MacDowell - Sex, Lies, and Videotape
Kelly Lynch - Drugstore Cowboy
Winona Ryder - Heathers
Youki Kudoh - Mystery Train
Annabella Sciorra - True Love
1991: Anjelica Huston - The Grifters
Eszter Balint - Bail Jumper
Carolyn Farina - Metropolitan
Joanne Woodward - Mr. & Mrs. Bridge
Mary Alice - To Sleep with Anger
1992: Judy Davis - Impromptu
Lili Taylor - Bright Angel
Mimi Rogers - The Rapture
Lily Tomlin - The Search for Signs of Inteligent Life in the Universe
Patsy Kensit - Twenty-One
1993: Fairuza Balk - Gas, Food Lodging
Catherine Keener - Johnny Suede
Edie Falco - Laws of Gravity
Cynda Williams - One False Move
Sheryl Lee - Twin Peaks: Fire Walk with Me
1994: Ashley Judd - Ruby in Paradise
Suzy Amis - The Ballad of Little Jo
May Chin - Hsi yen
Ariyan A. Johnson - Just Another Girl on the I.R.T.
Emma Thompson - Much Ado About Nothing
1995: Linda Fiorentino - The Last Seduction
Lauren Vélez - I Like It Like That
Jennifer Jason Leigh - Mrs. Parker and the Vicious Circle)
Karen Sillas - What Happened Was...
Chien-lien Wu - Yin shi nan nu
1996: Elisabeth Shue - Leaving Las Vegas
Lili Taylor - The addiction
Jennifer Jason Leigh - Georgia
Elina Löwensohn - Nadja
Julianne Moore - Safe
1997: Frances McDormand - Fargo
Maria Conchita Alonso - Caught
Scarlett Johansson - Manny & Lo
Catherine Keener - Walking and Talking
Renée Zellweger - The Whole Wide World
1998: Julie Christie - Afterglow
Alison Folland - All Over Me
Stacy Edwards - In the Company of Men
Robin Wright Penn - Loved
Lisa Harrow - Sunday
1999: Ally Sheedy - High Art
Katrin Cartlidge - Claire Dolan
Alfre Woodard - Down in the Delta
Robin Tunney - Niagara, Niagara
Christina Ricci - The Opposite of Sex

Thập niên 2000
2000: Hilary Swank - Boys Don't Cry
Reese Witherspoon - Election
Janet McTeer - Tumbleweeds
Susan Traylor - Valerie Flake
Diane Lane - A Walk on the Moon
2001: Ellen Burstyn - Requiem for a Dream
Joan Allen - The Contender
Sanaa Lathan - Love & Basketball
Kelly Macdonald - Two Family House
Laura Linney - You Can Count on Me
2002: Julianne Moore - Far From Heaven
Jennifer Aniston - The Good Girl
Catherine Keener - Lovely & Amazing
Parker Posey - Personal Velocity: Three Portraits
Maggie Gyllenhaal - Secretary
2003: Charlize Theron - Monster
Agnes Bruckner - Blue Car
Zooey Deschanel - All the Real Girls
Samantha Morton - In America
Elisabeth Moss - Virgin
2004: Catalina Sandino Moreno - Maria Full of Grace
Kimberly Elise - Woman Thou Art Loosed
Vera Farmiga - Down to the Bone
Judy Marte - On the Outs
Kyra Sedgwick - Cavedweller
2005: Felicity Huffman - Transamerica
Dina Korzun - Forty Shades of Blue
Laura Linney - The Squid and the Whale
S. Epatha Merkerson - Lackawanna Blues
Cyndi Williams - Room
2006: Shareeka Epps - Half Nelson
Catherine O'Hara - For Your Consideration
Robin Wright Penn - Sorry, Haters
Elizabeth Reaser - Sweet Land
Michelle Williams - Land of Plenty
2007: Ellen Page - Juno
Angelina Jolie - A Mighty Heart
Sienna Miller - Interview
Parker Posey - Broken English
Tang Wei - Lust, Caution (Sè, jiè)
2008: Melissa Leo - Frozen River
Summer Bishil - Towelhead
Anne Hathaway - Rachel Getting Married
Tarra Riggs - Ballast
Michelle Williams - Wendy and Lucy

Tham khảo