Giải quần vợt Mỹ Mở rộng 2008 - Đôi nam nữ

Cara Black Leander Paes
| runner = Liezel Huber Jamie Murray
| score = 7–6(8–6), 6–4
| before_name= Giải quần vợt Mỹ Mở rộng – Đôi nam nữ
| after_name= Giải quần vợt Mỹ Mở rộng – Đôi nam nữ
}}

Victoria Azarenka và Max Mirnyi là đương kim vô địch, tuy nhiên Azarenka không tham gia, và chỉ có Mirnyi thi đấu.
Mirnyi đánh cặp với Anna Chakvetadze, nhưng thất bại ở vòng một trước Nadia Petrova và Jonas Björkman.

Cara Black và Leander Paes giành chiến thắng trong trận chung kết 7–6(8–6), 6–4, trước Liezel Huber và Jamie Murray.

Hạt giống
Chia-jung Chuang / Daniel Nestor (Vòng một)
Katarina Srebotnik / Nenad Zimonjić (Tứ kết)
Ai Sugiyama / Kevin Ullyett (Vòng một)
Chiêm Vịnh Nhiên / Julian Knowle (Vòng một)
Cara Black / Leander Paes (Vô địch)
Květa Peschke / Pavel Vízner (Vòng hai)
Yan Zi / Mark Knowles (Vòng một)
Nathalie Dechy / Andy Ram (Vòng một)
}}

Kết quả

Chung kết
Cara Black Leander Paes
| RD1-score1-1=6
| RD1-score1-2=6
| RD1-score1-3=&nbsp;
| RD1-seed2=&nbsp;
| RD1-team2= Nadia Petrova Jonas Björkman
| RD1-score2-1=4
| RD1-score2-2=4
| RD1-score2-3=&nbsp;
| RD1-seed3=WC
| RD1-team3= Jill Craybas Eric Butorac
| RD1-score3-1=3
| RD1-score3-2=4
| RD1-score3-3=&nbsp;
| RD1-seed4=&nbsp;
| RD1-team4= Liezel Huber Jamie Murray
| RD1-score4-1=6
| RD1-score4-2=6
| RD1-score4-3=&nbsp;
| RD2-seed1=5
| RD2-team1= Cara Black Leander Paes
| RD2-score1-1=78
| RD2-score1-2=6
| RD2-score1-3=&nbsp;
| RD2-seed2=&nbsp;
| RD2-team2= Liezel Huber Jamie Murray
| RD2-score2-1=66
| RD2-score2-2=4
| RD2-score2-3=&nbsp;
}}

Nửa trên
C-j Chuang D Nestor
| RD1-score01-1=1
| RD1-score01-2=4
| RD1-score01-3=&nbsp;
| RD1-seed02=WC
| RD1-team02= S Stephens R Kendrick
| RD1-score02-1=6
| RD1-score02-2=6
| RD1-score02-3=&nbsp;
| RD1-seed03=WC
| RD1-team03= R Zalameda K Van't Hof
| RD1-score03-1=4
| RD1-score03-2=6
| RD1-score03-3=[8]
| RD1-seed04=&nbsp;
| RD1-team04= V Uhlířová M Damm
| RD1-score04-1=6
| RD1-score04-2=3
| RD1-score04-3=[10]
| RD1-seed05=&nbsp;
| RD1-team05= C Wozniacki M Matkowski
| RD1-score05-1=6
| RD1-score05-2=6
| RD1-score05-3=&nbsp;
| RD1-seed06=&nbsp;
| RD1-team06= S Pe'er P Hanley
| RD1-score06-1=0
| RD1-score06-2=4
| RD1-score06-3=&nbsp;
| RD1-seed07=WC
| RD1-team07= M Oudin D Young
| RD1-score07-1=3
| RD1-score07-2=2
| RD1-score07-3=&nbsp;
| RD1-seed08=5
| RD1-team08= C Black L Paes
| RD1-score08-1=6
| RD1-score08-2=6
| RD1-score08-3=&nbsp;
| RD1-seed09=4
| RD1-team09= Chiêm VN J Knowle
| RD1-score09-1=3
| RD1-score09-2=1
| RD1-score09-3=&nbsp;
| RD1-seed10=&nbsp;
| RD1-team10= C Dellacqua J Kerr
| RD1-score10-1=6
| RD1-score10-2=6
| RD1-score10-3=&nbsp;
| RD1-seed11=&nbsp;
| RD1-team11= A Chakvetadze M Mirnyi
| RD1-score11-1=3
| RD1-score11-2=1
| RD1-score11-3=&nbsp;
| RD1-seed12=&nbsp;
| RD1-team12= N Petrova J Björkman
| RD1-score12-1=6
| RD1-score12-2=6
| RD1-score12-3=&nbsp;
| RD1-seed13=WC
| RD1-team13= A Glatch S Lipsky
| RD1-score13-1=3
| RD1-score13-2=3
| RD1-score13-3=&nbsp;
| RD1-seed14=&nbsp;
| RD1-team14= S Stosur M Bhupathi
| RD1-score14-1=6
| RD1-score14-2=6
| RD1-score14-3=&nbsp;
| RD1-seed15=&nbsp;
| RD1-team15= R Stubbs R Lindstedt
| RD1-score15-1=6
| RD1-score15-2=6
| RD1-score15-3=&nbsp;
| RD1-seed16=8
| RD1-team16= N Dechy A Ram
| RD1-score16-1=4
| RD1-score16-2=4
| RD1-score16-3=&nbsp;
| RD2-seed01=WC
| RD2-team01= S Stephens R Kendrick
| RD2-score01-1=5
| RD2-score01-2=5
| RD2-score01-3=&nbsp;
| RD2-seed02=&nbsp;
| RD2-team02= V Uhlířová M Damm
| RD2-score02-1=7
| RD2-score02-2=7
| RD2-score02-3=&nbsp;
| RD2-seed03=&nbsp;
| RD2-team03= C Wozniacki M Matkowski
| RD2-score03-1=&nbsp;
| RD2-score03-2=&nbsp;
| RD2-score03-3=&nbsp;
| RD2-seed04=5
| RD2-team04= C Black L Paes
| RD2-score04-1=w/o
| RD2-score04-2=&nbsp;
| RD2-score04-3=&nbsp;
| RD2-seed05=&nbsp;
| RD2-team05= C Dellacqua J Kerr
| RD2-score05-1=3
| RD2-score05-2=3
| RD2-score05-3=&nbsp;
| RD2-seed06=&nbsp;
| RD2-team06= N Petrova J Björkman
| RD2-score06-1=6
| RD2-score06-2=6
| RD2-score06-3=&nbsp;
| RD2-seed07=&nbsp;
| RD2-team07= S Stosur M Bhupathi
| RD2-score07-1=6
| RD2-score07-2=3
| RD2-score07-3=[10]
| RD2-seed08=&nbsp;
| RD2-team08= R Stubbs R Lindstedt
| RD2-score08-1=2
| RD2-score08-2=6
| RD2-score08-3=[12]
| RD3-seed01=&nbsp;
| RD3-team01= V Uhlířová M Damm
| RD3-score01-1=5
| RD3-score01-2=2
| RD3-score01-3=&nbsp;
| RD3-seed02=5
| RD3-team02= C Black L Paes
| RD3-score02-1=7
| RD3-score02-2=6
| RD3-score02-3=&nbsp;
| RD3-seed03=&nbsp;
| RD3-team03= N Petrova J Björkman
| RD3-score03-1=6
| RD3-score03-2=6
| RD3-score03-3=&nbsp;
| RD3-seed04=&nbsp;
| RD3-team04= R Stubbs R Lindstedt
| RD3-score04-1=3
| RD3-score04-2=2
| RD3-score04-3=&nbsp;
| RD4-seed01=5
| RD4-team01= C Black L Paes
| RD4-score01-1=6
| RD4-score01-2=6
| RD4-score01-3=&nbsp;
| RD4-seed02=&nbsp;
| RD4-team02= N Petrova J Björkman
| RD4-score02-1=4
| RD4-score02-2=4
| RD4-score02-3=&nbsp;
}}

Nửa dưới
Z Yan M Knowles
| RD1-score01-1=67
| RD1-score01-2=3
| RD1-score01-3=r
| RD1-seed02=&nbsp;
| RD1-team02= E Vesnina M Fyrstenberg
| RD1-score02-1=79
| RD1-score02-2=2
| RD1-score02-3=&nbsp;
| RD1-seed03=&nbsp;
| RD1-team03= J Husárová J Coetzee
| RD1-score03-1=1
| RD1-score03-2=1
| RD1-score03-3=&nbsp;
| RD1-seed04=Alt
| RD1-team04= F Pennetta D Vemić
| RD1-score04-1=6
| RD1-score04-2=6
| RD1-score04-3=&nbsp;
| RD1-seed05=&nbsp;
| RD1-team05= L Raymond M Melo
| RD1-score05-1=6
| RD1-score05-2=6
| RD1-score05-3=&nbsp;
| RD1-seed06=&nbsp;
| RD1-team06= S Peng L Dlouhý
| RD1-score06-1=3
| RD1-score06-2=2
| RD1-score06-3=&nbsp;
| RD1-seed07=WC
| RD1-team07= J Craybas E Butorac
| RD1-score07-1=6
| RD1-score07-2=6
| RD1-score07-3=&nbsp;
| RD1-seed08=3
| RD1-team08= A Sugiyama K Ullyett
| RD1-score08-1=4
| RD1-score08-2=4
| RD1-score08-3=&nbsp;
| RD1-seed09=6
| RD1-team09= K Peschke P Vízner
| RD1-score09-1=6
| RD1-score09-2=2
| RD1-score09-3=[10]
| RD1-seed10=&nbsp;
| RD1-team10= D Cibulková J Melzer
| RD1-score10-1=4
| RD1-score10-2=6
| RD1-score10-3=[6]
| RD1-seed11=&nbsp;
| RD1-team11= K Bondarenko A Sá
| RD1-score11-1=3
| RD1-score11-2=2
| RD1-score11-3=&nbsp;
| RD1-seed12=&nbsp;
| RD1-team12= L Huber J Murray
| RD1-score12-1=6
| RD1-score12-2=6
| RD1-score12-3=&nbsp;
| RD1-seed13=Alt
| RD1-team13= V Razzano R Wassen
| RD1-score13-1=6
| RD1-score13-2=3
| RD1-score13-3=[10]
| RD1-seed14=&nbsp;
| RD1-team14= T Poutchek C Kas
| RD1-score14-1=2
| RD1-score14-2=6
| RD1-score14-3=[5]
| RD1-seed15=Alt
| RD1-team15= A Rodionova J Cerretani
| RD1-score15-1=3
| RD1-score15-2=2
| RD1-score15-3=&nbsp;
| RD1-seed16=2
| RD1-team16= K Srebotnik N Zimonjić
| RD1-score16-1=6
| RD1-score16-2=6
| RD1-score16-3=&nbsp;
| RD2-seed01=&nbsp;
| RD2-team01= E Vesnina M Fyrstenberg
| RD2-score01-1=4
| RD2-score01-2=5
| RD2-score01-3=&nbsp;
| RD2-seed02=Alt
| RD2-team02= F Pennetta D Vemić
| RD2-score02-1=6
| RD2-score02-2=7
| RD2-score02-3=&nbsp;
| RD2-seed03=&nbsp;
| RD2-team03= L Raymond M Melo
| RD2-score03-1=5
| RD2-score03-2=5
| RD2-score03-3=&nbsp;
| RD2-seed04=WC
| RD2-team04= J Craybas E Butorac
| RD2-score04-1=7
| RD2-score04-2=7
| RD2-score04-3=&nbsp;
| RD2-seed05=6
| RD2-team05= K Peschke P Vízner
| RD2-score05-1=5
| RD2-score05-2=3
| RD2-score05-3=&nbsp;
| RD2-seed06=&nbsp;
| RD2-team06= L Huber J Murray
| RD2-score06-1=7
| RD2-score06-2=6
| RD2-score06-3=&nbsp;
| RD2-seed07=Alt
| RD2-team07= V Razzano R Wassen
| RD2-score07-1=1
| RD2-score07-2=7
| RD2-score07-3=[8]
| RD2-seed08=2
| RD2-team08= K Srebotnik N Zimonjić
| RD2-score08-1=6
| RD2-score08-2=5
| RD2-score08-3=[10]
| RD3-seed01=Alt
| RD3-team01= F Pennetta D Vemić
| RD3-score01-1=7
| RD3-score01-2=4
| RD3-score01-3=[4]
| RD3-seed02=WC
| RD3-team02= J Craybas E Butorac
| RD3-score02-1=64
| RD3-score02-2=6
| RD3-score02-3=[10]
| RD3-seed03=&nbsp;
| RD3-team03= L Huber J Murray
| RD3-score03-1=77
| RD3-score03-2=69
| RD3-score03-3=[11]
| RD3-seed04=2
| RD3-team04= K Srebotnik N Zimonjić
| RD3-score04-1=65
| RD3-score04-2=711
| RD3-score04-3=[9]
| RD4-seed01=WC
| RD4-team01= J Craybas E Butorac
| RD4-score01-1=3
| RD4-score01-2=4
| RD4-score01-3=&nbsp;
| RD4-seed02=&nbsp;
| RD4-team02= L Huber J Murray
| RD4-score02-1=6
| RD4-score02-2=6
| RD4-score02-3=&nbsp;
}}

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