Giải quần vợt Mỹ Mở rộng 2010 - Đôi nam nữ

Liezel Huber Bob Bryan
| runner = Květa Peschke Aisam-ul-Haq Qureshi
| score = 6–4, 6–4
| before_name= Giải quần vợt Mỹ Mở rộng – Đôi nam nữ
| after_name= Giải quần vợt Mỹ Mở rộng – Đôi nam nữ
}}

Carly Gullickson và Travis Parrott là đương kim vô địch, nhưng thất bại ở vòng một trước Gisela Dulko và Pablo Cuevas 2–6, 4–6.
Liezel Huber và Bob Bryan giành chiến thắng trong trận chung kết 6–4, 6–4, trước Květa Peschke và Aisam-ul-Haq Qureshi.

Hạt giống
Liezel Huber / Bob Bryan (Vô địch)
Cara Black / Leander Paes (Tứ kết)
Katarina Srebotnik / Nenad Zimonjić (Vòng hai)
Bethanie Mattek-Sands / Daniel Nestor (Bán kết)
Rennae Stubbs / Dick Norman (Vòng một)
Elena Vesnina / Andy Ram (Vòng hai)
Lisa Raymond / Wesley Moodie (Tứ kết)
Vania King / Horia Tecău (Vòng một)
}}

Kết quả

Chung kết
Liezel Huber Bob Bryan
| RD1-score1-1=6
| RD1-score1-2=7
| RD1-score1-3=&nbsp;
| RD1-seed2=4
| RD1-team2= Bethanie Mattek-Sands Daniel Nestor
| RD1-score2-1=3
| RD1-score2-2=5
| RD1-score2-3=&nbsp;

| RD1-seed3=&nbsp;
| RD1-team3= Květa Peschke Aisam-ul-Haq Qureshi
| RD1-score3-1=7
| RD1-score3-2=7
| RD1-score3-3=&nbsp;
| RD1-seed4=&nbsp;
| RD1-team4= Anna-Lena Grönefeld Mark Knowles
| RD1-score4-1=65
| RD1-score4-2=64
| RD1-score4-3=&nbsp;

| RD2-seed1=1
| RD2-team1= Liezel Huber Bob Bryan
| RD2-score1-1=6
| RD2-score1-2=6
| RD2-score1-3=&nbsp;
| RD2-seed2=&nbsp;
| RD2-team2= Květa Peschke Aisam-ul-Haq Qureshi
| RD2-score2-1=4
| RD2-score2-2=4
| RD2-score2-3=&nbsp;
}}

Nửa trên
L Huber B Bryan
| RD1-score01-1=6
| RD1-score01-2=6
| RD1-score01-3=&nbsp;
| RD1-seed02=Alt
| RD1-team02= S-w Hsieh B Soares
| RD1-score02-1=4
| RD1-score02-2=3
| RD1-score02-3=&nbsp;

| RD1-seed03=WC
| RD1-team03= M Oudin R Harrison
| RD1-score03-1=6
| RD1-score03-2=7
| RD1-score03-3=&nbsp;
| RD1-seed04=&nbsp;
| RD1-team04= A Hlaváčková M Mertiňák
| RD1-score04-1=1
| RD1-score04-2=5
| RD1-score04-3=&nbsp;

| RD1-seed05=&nbsp;
| RD1-team05= T Bacsinszky O Marach
| RD1-score05-1=1
| RD1-score05-2=3
| RD1-score05-3=&nbsp;
| RD1-seed06=&nbsp;
| RD1-team06= O Govortsova M Matkowski
| RD1-score06-1=6
| RD1-score06-2=6
| RD1-score06-3=&nbsp;

| RD1-seed07=&nbsp;
| RD1-team07= A Medina Garrigues}} M López
| RD1-score07-1=1
| RD1-score07-2=64
| RD1-score07-3=&nbsp;
| RD1-seed08=7
| RD1-team08= L Raymond W Moodie
| RD1-score08-1=6
| RD1-score08-2=7
| RD1-score08-3=&nbsp;

| RD1-seed09=4
| RD1-team09= B Mattek-Sands D Nestor
| RD1-score09-1=6
| RD1-score09-2=2
| RD1-score09-3=[10]
| RD1-seed10=WC
| RD1-team10= B Capra J Sock
| RD1-score10-1=2
| RD1-score10-2=6
| RD1-score10-3=[7]

| RD1-seed11=&nbsp;
| RD1-team11= Z Yan R Bopanna
| RD1-score11-1=2
| RD1-score11-2=4
| RD1-score11-3=&nbsp;
| RD1-seed12=&nbsp;
| RD1-team12= A Rezaï R Ram
| RD1-score12-1=6
| RD1-score12-2=6
| RD1-score12-3=&nbsp;

| RD1-seed13=&nbsp;
| RD1-team13= Y-j Chan P Hanley
| RD1-score13-1=6
| RD1-score13-2=6
| RD1-score13-3=&nbsp;
| RD1-seed14=Alt
| RD1-team14= A Dulgheru D Marrero
| RD1-score14-1=4
| RD1-score14-2=2
| RD1-score14-3=&nbsp;

| RD1-seed15=WC
| RD1-team15= A Spears S Lipsky
| RD1-score15-1=7
| RD1-score15-2=7
| RD1-score15-3=&nbsp;
| RD1-seed16=5
| RD1-team16= R Stubbs D Norman
| RD1-score16-1=64
| RD1-score16-2=63
| RD1-score16-3=&nbsp;

| RD2-seed01=1
| RD2-team01= L Huber B Bryan
| RD2-score01-1=5
| RD2-score01-2=6
| RD2-score01-3=[10]
| RD2-seed02=WC
| RD2-team02= M Oudin R Harrison
| RD2-score02-1=7
| RD2-score02-2=1
| RD2-score02-3=[3]

| RD2-seed03=&nbsp;
| RD2-team03= O Govortsova M Matkowski
| RD2-score03-1=4
| RD2-score03-2=65
| RD2-score03-3=&nbsp;
| RD2-seed04=7
| RD2-team04= L Raymond W Moodie
| RD2-score04-1=6
| RD2-score04-2=7
| RD2-score04-3=&nbsp;

| RD2-seed05=4
| RD2-team05= B Mattek-Sands D Nestor}}
| RD2-score05-1=62
| RD2-score05-2=6
| RD2-score05-3=[10]
| RD2-seed06=&nbsp;
| RD2-team06= A Rezaï R Ram
| RD2-score06-1=7
| RD2-score06-2=2
| RD2-score06-3=[5]

| RD2-seed07=&nbsp;
| RD2-team07= Y-j Chan P Hanley
| RD2-score07-1=6
| RD2-score07-2=5
| RD2-score07-3=[10]
| RD2-seed08=WC
| RD2-team08= A Spears S Lipsky
| RD2-score08-1=2
| RD2-score08-2=7
| RD2-score08-3=[5]

| RD3-seed01=1
| RD3-team01= L Huber B Bryan
| RD3-score01-1=6
| RD3-score01-2=7
| RD3-score01-3=&nbsp;
| RD3-seed02=7
| RD3-team02= L Raymond W Moodie
| RD3-score02-1=4
| RD3-score02-2=63
| RD3-score02-3=&nbsp;

| RD3-seed03=4
| RD3-team03= B Mattek-Sands D Nestor}}
| RD3-score03-1=6
| RD3-score03-2=6
| RD3-score03-3=&nbsp;
| RD3-seed04=&nbsp;
| RD3-team04= Y-j Chan P Hanley
| RD3-score04-1=4
| RD3-score04-2=3
| RD3-score04-3=&nbsp;

| RD4-seed01=1
| RD4-team01= L Huber B Bryan
| RD4-score01-1=6
| RD4-score01-2=7
| RD4-score01-3=&nbsp;
| RD4-seed02=4
| RD4-team02= B Mattek-Sands D Nestor}}
| RD4-score02-1=3
| RD4-score02-2=5
| RD4-score02-3=&nbsp;
}}

Nửa dưới
V King H Tecău
| RD1-score01-1=5
| RD1-score01-2=6
| RD1-score01-3=[5]
| RD1-seed02=&nbsp;
| RD1-team02= K Peschke A-u-H Qureshi
| RD1-score02-1=7
| RD1-score02-2=4
| RD1-score02-3=[10]

| RD1-seed03=WC
| RD1-team03= J Craybas M Russell
| RD1-score03-1=63
| RD1-score03-2=7
| RD1-score03-3=[1]
| RD1-seed04=&nbsp;
| RD1-team04= Y Shvedova J Knowle
| RD1-score04-1=7
| RD1-score04-2=5
| RD1-score04-3=[10]

| RD1-seed05=WC
| RD1-team05= C Gullickson T Parrott
| RD1-score05-1=2
| RD1-score05-2=4
| RD1-score05-3=&nbsp;
| RD1-seed06=&nbsp;
| RD1-team06= G Dulko P Cuevas
| RD1-score06-1=6
| RD1-score06-2=6
| RD1-score06-3=&nbsp;

| RD1-seed07=&nbsp;
| RD1-team07= A Petkovic M Fyrstenberg
| RD1-score07-1=63
| RD1-score07-2=62
| RD1-score07-3=&nbsp;
| RD1-seed08=3
| RD1-team08= K Srebotnik N Zimonjić
| RD1-score08-1=7
| RD1-score08-2=7
| RD1-score08-3=&nbsp;

| RD1-seed09=6
| RD1-team09= E Vesnina A Ram
| RD1-score09-1=6
| RD1-score09-2=66
| RD1-score09-3=[11]
| RD1-seed10=WC
| RD1-team10= R Kops-Jones E Butorac
| RD1-score10-1=4
| RD1-score10-2=7
| RD1-score10-3=[9]

| RD1-seed11=&nbsp;
| RD1-team11= A-L Grönefeld M Knowles
| RD1-score11-1=6
| RD1-score11-2=6
| RD1-score11-3=&nbsp;
| RD1-seed12=WC
| RD1-team12= N Gibbs S Querrey
| RD1-score12-1=3
| RD1-score12-2=2
| RD1-score12-3=&nbsp;

| RD1-seed13=&nbsp;
| RD1-team13= D Hantuchová M Bhupathi
| RD1-score13-1=4
| RD1-score13-2=2
| RD1-score13-3=&nbsp;
| RD1-seed14=&nbsp;
| RD1-team14= K Kanepi R Lindstedt
| RD1-score14-1=6
| RD1-score14-2=6
| RD1-score14-3=&nbsp;

| RD1-seed15=&nbsp;
| RD1-team15= L Hradecká F Čermák
| RD1-score15-1=4
| RD1-score15-2=5
| RD1-score15-3=&nbsp;
| RD1-seed16=2
| RD1-team16= C Black L Paes
| RD1-score16-1=6
| RD1-score16-2=7
| RD1-score16-3=&nbsp;

| RD2-seed01=&nbsp;
| RD2-team01= K Peschke A-u-H Qureshi
| RD2-score01-1=5
| RD2-score01-2=6
| RD2-score01-3=[10]
| RD2-seed02=&nbsp;
| RD2-team02= Y Shvedova J Knowle
| RD2-score02-1=7
| RD2-score02-2=3
| RD2-score02-3=[4]

| RD2-seed03=&nbsp;
| RD2-team03= G Dulko P Cuevas
| RD2-score03-1=7
| RD2-score03-2=7
| RD2-score03-3=&nbsp;
| RD2-seed04=3
| RD2-team04= K Srebotnik N Zimonjić
| RD2-score04-1=5
| RD2-score04-2=5
| RD2-score04-3=&nbsp;

| RD2-seed05=6
| RD2-team05= E Vesnina A Ram
| RD2-score05-1=6
| RD2-score05-2=3
| RD2-score05-3=[7]
| RD2-seed06=&nbsp;
| RD2-team06= A-L Grönefeld M Knowles
| RD2-score06-1=4
| RD2-score06-2=6
| RD2-score06-3=[10]

| RD2-seed07=&nbsp;
| RD2-team07= K Kanepi R Lindstedt
| RD2-score07-1=4
| RD2-score07-2=1
| RD2-score07-3=&nbsp;
| RD2-seed08=2
| RD2-team08= C Black L Paes
| RD2-score08-1=6
| RD2-score08-2=6
| RD2-score08-3=&nbsp;

| RD3-seed01=&nbsp;
| RD3-team01= K Peschke A-u-H Qureshi
| RD3-score01-1=3
| RD3-score01-2=6
| RD3-score01-3=[10]
| RD3-seed02=&nbsp;
| RD3-team02= G Dulko P Cuevas
| RD3-score02-1=6
| RD3-score02-2=2
| RD3-score02-3=[4]

| RD3-seed03=&nbsp;
| RD3-team03= A-L Grönefeld M Knowles
| RD3-score03-1=6
| RD3-score03-2=6
| RD3-score03-3=&nbsp;
| RD3-seed04=2
| RD3-team04= C Black L Paes
| RD3-score04-1=3
| RD3-score04-2=4
| RD3-score04-3=&nbsp;

| RD4-seed01=&nbsp;
| RD4-team01= K Peschke A-u-H Qureshi
| RD4-score01-1=7
| RD4-score01-2=7
| RD4-score01-3=&nbsp;
| RD4-seed02=&nbsp;
| RD4-team02= A-L Grönefeld M Knowles
| RD4-score02-1=65
| RD4-score02-2=64
| RD4-score02-3=&nbsp;
}}

Liên kết ngoài
Main draw