INDICATIONS AND
USAGE
Demeclocycline hydrochloride tablets USP is indicated in the treatment of infections caused by susceptible strains of the designated microorganisms in the conditionsbelow:
Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick
fevers caused by rickettsiae; Respiratory tract infections caused by Mycoplasma pneumoniae; Lymphogranuloma venereum due to Chlamydia trachomatis; Psittacosis (Ornithosis) due to Chlamydia
psittaci; Trachoma due to Chlamydia trachomatis, although the infectious agent is not always eliminated,
as
judged by immunofluorescence; Inclusion conjunctivitis
caused by Chlamydia
trachomatis;Nongonococcal urethritis in adults caused by Ureaplasma
urealyticum or Chlamydia trachomatis; Relapsing
fever due
to
Borrelia
recurrentis;
Chancroid caused by Haemophilus ducreyi; Plague due to Yersinia
pestis;
Tularemia due to Francisella tularensis; Cholera caused by Vibrio
cholerae;
Campylobacter fetus infections caused by Campylobacter
fetus; Brucellosis due to Brucella species (in conjunction with streptomycin); Bartonellosis due to Bartonella
bacilliformis;
Granuloma inguinale caused by Calymmatobacterium
granulomatis;
Demeclocycline hydrochloride tablets USP is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to thedrug:
Escherichia
coli; Enterobacter aerogenes; Shigella species; Acinetobacter
species;
Respiratory tract infections caused by Haemophilus influenzae; Respiratory tract and urinary tract infections causedby Klebsiella
species.
Demeclocycline hydrochloride tablets USP is indicated for treatment of infections caused by the following gram-positive microorganisms, when bacteriologic testing indicates appropriate susceptibility to thedrug:
Upper respiratory infections caused by Streptococcus pneumoniae; Skin and skin structure infections caused by Staphylococcus aureus.
(Note: Tetracyclines, including demeclocycline, are not the drugs of choice in the treatment of any type ofstaphylococcalinfection.) When penicillin is contraindicated, tetracyclines, including demeclocycline hydrochloride, are alternative drugs in the treatment of the followinginfections:
Uncomplicated urethritis in men due to Neisseria
gonorrhoeae, and for the treatment of other uncomplicated gonococcal infections; Infections in women caused by Neisseria
gonorrhoeae;
Syphilis caused by Treponema
pallidum subspecies pallidum; Yaws caused by Treponema
pallidum subspecies pertenue; Listeriosis duetoListeria
monocytogenes;
Anthrax due toBacillus
anthracis;
Vincents infection caused by Fusobacterium fusiforme; Actinomycosis caused by Actinomyces
israelii; Clostridial diseases caused by Clostridium
species.
In acute intestinal amebiasis, demeclocycline hydrochloride tablets USP may be a useful adjunct toamebicides.
In severe acne, demeclocycline hydrochloride tablets USP may be a useful adjunctive
therapy.
To reduce the development of drug-resistant bacteria and maintain the effectiveness ofdemeclocyclinehydrochloride tablets USP and other antibacterial drugs, demeclocycline hydrochloride tablets USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiricselection oftherapy.