INDICATIONS AND USAGE
Minocycline Hydrochloride Capsules are indicated in the treatment of the following infections due to susceptible strains of the designated microorganisms:Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by RickettsiaeRespiratory tract infections caused by Mycoplasma pneumoniaeLymphogranuloma venereum caused by Chlamydia trachomatisPsittacosis (Ornithosis) due to Chlamydia psittaciTrachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated, as judged by immunofluorescenceInclusion conjunctivitis caused by Chlamydia trachomatisNongonococcal urethritis, endocervical, or rectal infections in adults caused by Ureaplasma urealyticum or Chlamydia trachomatisRelapsing fever due to Borrelia recurrentisChancroid caused by Haemophilus ducreyiPlague due to Yersinia pestisTularemia due to Francisella tularensisCholera caused by Vibrio choleraeCampylobacter fetus infections caused by Campylobacter fetusBrucellosis due to Brucella species (in conjunction with streptomycin)Brucellosis due to Bartonella bacilliformisGranuloma inguinale caused by Calymmatobacterium granulomatisMinocycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug:Escherichia coliEnterobacter aerogenesShigella speciesAcinetobacter speciesRespiratory tract infections caused by Haemophilus influenzaeRespiratory tract and urinary tract infections caused by Klebsiella speciesMinocycline hydrochloride capsules are indicated for the treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug: Upper respiratory tract infections caused by Streptococcus pneumoniaeSkin and skin structure infections caused by Straphylococcus aureus.(Note: Minocycline is not the drug of choice in the treatment of any type of staphylococcal infection.)When penicillin is contraindicated, minocycline is an alternative drug in the treatment of the following infections: Uncomplicated urethritis in men due to Neisseria gonorrhoeae and for the treatment of other gonococcal infections when penicillin is contraindicated.Infections in women caused by Neisseria gonorrhoeaeSyphilis caused by Treponema pallidum subspecies pallidumYaws caused by Treponema pallidum subspecies pertenueListeriosis due to Listeria monocytogenesAnthrax due to Bacillus anthracisVincent's infection caused by Fusobacteruim fusiformeActinomycosis caused by Actinomyces israeliiInfections caused by Clostridium speciesIn acute intestinal amebiasis, minocycline may be a useful adjunct to amebicides.In severe acne, minocycline may be useful adjunctive therapy.Oral minocycline is indicated in the treatment of asymptomatic carriers of Neisseriameningitidis to eliminate meningococci from the nasopharynx. In order to preserve the usefulness of minocycline in the treatment of asymptomatic meningococcal carriers, diagnostic laboratory procedures, including serotyping and susceptibility testing, should be performed to establish the carrier state and the correct treatment. It is recommended that the prophylactic use of minocycline be reserved for situations in which the risk of meningococcal meningitis is high. Oral minocycline is not indicated for the treatment of meningococcal infection.Although no controlled clinical efficacy studies have been conducted, limited clinical data show that oral minocycline hydrochloride has been used successfully in the treatment of infections caused by Mycobacteriummarinum.To reduce the development of drug-resistant bacteria and maintain the effectiveness of minocycline hydrochloride capsules and other antibacterial drugs, minocycline hydrochloride capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.