INDICATIONS AND USAGE
To reduce the development of drug-resistant bacteria and maintain effectiveness of doxycycline hyclateand other antibacterial drugs, doxycycline hyclateshould be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Treatment:
Doxycycline is indicated for the treatment of the following infections:
Rocky Mountain spotted fever, typhus fever and the typhus group, Q. fever, rickettsialpox, and tick fevers caused by Rickettsiae.
Respiratory tract infections caused by
Mycoplasma pneumoniae.
Lymphogranuloma venereum caused by
Chlamydia trachomatis.
Psittacosis (ornithosis) caused by
Chlamydia psittaci.
Trachoma caused by
Chlamydia trachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence.
Inclusion conjunctivitis caused by
Chlamydia trachomatis.
Uncomplicated urethral, endocervical or rectal infections in adults caused by
Chlamydia trachomatis.
Nongonococcal urethritis caused by
Ureaplasma urealyticum.
Relapsing fever due to
Borrelia recurrentis.
Doxycycline is also indicated for the treatment of infections caused by the following gram-negative microorganisms:
Chancroid caused by
Haemophilus ducreyi.
Plague due to
Yersinia pestis (formerly
Pasteurella pestis).
Tuleremia due to
Francisella tulerensis (formerly
Pasteurella tulerensis).
Cholera caused by
Vibrio cholerae (formerly
Vibrio comma).
Campylobacter fetus infections caused by
Campylobacter fetus (formerly
Vibrio fetus).
Brucellosis due to
Brucella species (in conjunction with streptomycin).
Bartonellosis due to
Bartonella baciliformis.
Granuloma inguinale caused by
Calymmatobacterium granulomatis.
Because many strains of the following groups of microorganisms have been shown to be resistant to doxycycline culture and susceptibility testing are recommended.
Doxycycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug:
Escherichia coli.
Enterobacter aerogenes (formerly
Aerobacter aerogenes).
Shigella species.
Acinetobacter species (formerly
Mima species and
Herellea species).
Respiratory tract infections caused by
Haemophilus influenzae.
Respiratory tract and urinary tract infections caused by
Klebsiella species.
Doxycycline is indicated for treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:
Upper respiratory infections caused by
Streptococcus pneumonie (formerly
Diplococcus pneumoniae).
Anthrax due to
Bacillus anthracis, including inhalational anthrax (post-exposure): to reduce the incidence or progression of disease following exposure to aerosolized
Bacillus anthracis.
When penicillin is contraindicated doxycycline is an alternative drug in the treatment of the following infections:
Uncomplicated gonorrhea caused by
Neisseria gonorrhoeae.
Syphilis caused by
Treponema pallidum.
Yaws caused by
Treponema pertenue.
Listeriosis due to
Listeria monocytogenes.
Vincent's infection caused by
Fusobacterium fusiforme.
Actinomycosis caused by
Actinomyces israelii.
Infections caused by
Clostridium species.
In acute intestinal amebiasis, doxycycline may be a useful adjunct to amebicides.
In severe acne, doxycycline may be useful adjunctive therapy.
Prophylaxis:
Doxycycline is indicated for the prophylaxis of malaria due to
Plasmodium falciparum in short-term travelers (<4 months) areas with chloroquine and/or pyrimethamine-sulfadoxine resistant strains. See
DOSAGE AND ADMINISTRATION
section and
Information for Patients subsection of the PRECAUTIONS
section.