INDICATIONS AND USAGE
To reduce the development of drug-resistant bacteria and maintain effectiveness of doxycycline hyclate and other antibacterial drugs, doxycycline hyclate should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Treatment
:
Doxycycline is indicated for the treatment of the following infections:
Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever,rickettsialpox, and tick fevers caused by Rickettsiae.
Respiratory tract infections caused by .
Mycoplasma pneumoniae
Lymphogranuloma venereum caused by .
Chlamydia trachomatis
Psittacosis (ornithosis) caused by .
Chlamydia
psittaci
Trachoma caused by , although the infectious agent is not alwayseliminated, as judged by immunofluorescence.
Chlamydia trachomatis
Inclusion conjunctivitis caused by .
Chlamydia trachomatis
Uncomplicated urethral, endocervical, or rectal infections in adults caused by .
Chlamydia
trachomatis
Nongonococcal urethritis caused by .
Ureaplasma urealyticum
Relapsing fever due to .
Borrelia recurrentis
Doxycycline is also indicated for the treatment of infections caused by the following gram-negative microorganisms:
Chancroid caused by .
Haemophilus ducreyi
Plague due to (formerly ).
Yersinia pestis
Pasteurella pestis
Tularemia due to (formerly ).
Francisella tularensis
Pasteurella tularensis
Cholera caused by (formerly ).
Vibrio cholerae
Vibrio comma
Campylobacter fetus infections caused by (formerly ).
Campylobacter
fetus
Vibrio fetus
Brucellosis due to species (in conjunction with streptomycin).
Brucella
Bartonellosis due to .
Bartonella bacilliformis
Granuloma inguinale caused by .
Calymmatobacterium granulomatis
Because many strains of the following groups of microorganisms have been shown to be resistant to doxycycline, culture and susceptibility testing are recommended.
Doxycycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug:
Escherichia coli.
(formerly ).
Enterobacter aerogenes
Aerobacter
aerogenes
species.
Shigella
species (formerly species and species).
Acinetobacter
Mima
He
rellea
Respiratory tract infections caused by .
Haemophilus influenzae
Respiratory tract and urinary tract infections caused by species.
Klebsiella
Doxycycline is indicated for treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:
Upper respiratory infections caused by (formerly ).
Streptococcus pneumoniae
Diplococcus pneumoniae
Anthrax due to , including inhalational anthrax (post-exposure): to reduce the incidence or progression of disease following exposure to aerosolized .
Bacillus anthracis
Bacillus anthracis
When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of the following infections:
Uncomplicated gonorrhea caused by .
Neisseria gonorrhoeae
Syphilis caused by .
Treponema pallidum
Yaws caused by .
Treponema pertenue
Listeriosis due to .
Listeria monocytogenes
Vincents infection caused by .
Fusobacterium fusiforme
Actinomycosis caused by .
Actinomyces isr
aelii
Infections caused by species.
Clostridium
In acute intestinal amebiasis, doxycycline may be a useful adjunct to amebicides.
In severe acne, doxycycline may be useful adjunctive therapy.
Prophylaxis:
Doxycycline is indicated for the prophylaxis of malaria due to in short-term travelers (<4 months) to areas with chloroquine and/or pyrimethamine-sulfadoxine resistant strains. (See section and subsection of the section.)
Plasmodium falciparum
DOSAGE AND ADMINISTRATION
Information for Patients
PRECAUTIONS