INDICATIONS AND USAGE
To reduce the development of drug-resistant bacteria and maintain the effectiveness of DORYX and other antibacterial drugs, DORYX should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Treatment
Doxycycline is indicated for the treatment of the following infections: Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae. Respiratory tract infections caused by Mycoplasma pneumoniae. Lymphogranuloma venereum caused by Chlamydia trachomatis.Psittacosis (ornithosis) caused by Chlamydia psittaci.Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence.Inclusion conjunctivitis caused by Chlamydia trachomatis.Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis.Nongonococcal urethritis caused by Ureaplasma urealyticum.Relapsing fever due to Borrelia recurrentis.Doxycycline is also indicated for the treatment of infections caused by the following gram-negative microorganisms:Chancroid caused by Haemophilus ducreyi.Plague due to Yersinia pestis (formerly Pasteurella pestis).Tularemia due to Francisella tularensis (formerly Pasteurella tularensis).Cholera caused by Vibrio cholerae (formerly Vibrio comma).Campylobacter fetus infections caused by Campylobacter fetus (formerly Vibrio fetus).Brucellosis due to Brucella species (in conjunction with streptomycin).Bartonellosis due to Bartonella bacilliformis.Granuloma inguinale caused by Calymmatobacterium granulomatis.Because many strains of the following groups of microorganisms have been shown to be resistant to doxycycline, culture and susceptibility testing are recommended.Doxycycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriological testing indicates appropriate susceptibility to the drug:Escherichia coliEnterobacter aerogenes (formerly Aerobacter aerogenes)Shigella speciesAcinetobacter species (formerly Mima species and Herellea species)Respiratory tract infections caused by Haemophilis influenzae Respiratory tract and urinary tract infections caused by Klebsiella species Doxycycline is indicated for treatment of infections caused by the following gram-positive microorganisms when bacteriological testing indicates appropriate susceptibility to the drug: Upper respiratory infections caused by Streptococcus pneumoniae (formerly Diplococcus pneumonia)Anthrax due to Bacillus anthracis, including inhalation anthrax (post-exposure): to reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis.When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of infections due to:Uncomplicated gonorrhea caused by Neisseria gonorrhoeaeSyphillis caused by Treponema pallidum Yaws caused by Treponema pertenue Listeriosis due to Listeria monocytogenesVincents infection caused by Fusobacterium fusiforme Actinomycosis caused by Actinomyces israelliInfections caused by Clostridium speciesIn acute intestinal amebiasis doxycycline may be a useful adjunct to amebicides.In severe acne doxycycline may be useful adjunctive therapy.
Prophylaxis:
Doxycycline is indicated for the prophylaxis of malaria due to Plasmodium falciparum in short-term travelers (<4 months) to areas with chloroquine and/or pyrimethamine-sulfadoxine resistant strains. See DOSAGE AND ADMINISTRATION section and Information for Patients subsections of the PRECAUTIONS section.