INDICATIONS AND USAGE
To reduce the development of drug-resistant bacteria and maintain effectiveness of doxycycline for oral suspension and other antibacterial drugs, doxycycline for oral suspension should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Treatment
Doxycycline is indicated for the treatment of the following infections:
Rocky Mountain
spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox,
and tick fevers caused by Rickettsiae.
Respiratory tract
infections caused by Mycoplasma pneumoniae .
Lymphogranuloma
venereum caused by Chlamydia trachomatis .
Psittacosis
(ornithosis) caused by Chlamydophila psittaci .
Trachoma caused by Chlamydia trachomatis , although the infectious agent is not always
eliminated, as judged by immunofluorescence.
Inclusion
conjunctivitis caused by Chlamydia trachomatis .
Uncomplicated urethral,
endocervical, or rectal infections in adults caused by Chlamydia
trachomatis .
Nongonococcal
urethritis caused by Ureaplasma urealyticum .
Relapsing fever
due to Borrelia recurrentis .
Doxycycline is also indicated for the treatment of infections caused by the following gram-negative microorganisms:
Chancroid caused
by Haemophilus ducreyi .
Plague due to Yersinia pestis .
Tularemia due to Francisella tularensis.
Cholera caused by Vibrio cholerae .
Campylobacter fetus infections caused by Campylobacter
fetus .
Brucellosis due to Brucella species (in conjunction
with streptomycin).
Bartonellosis due to Bartonella bacilliformis .
Granuloma inguinale caused by Klebsiella
granulomatis .
Because many strains of the following groups of microorganisms have been shown to be resistant to doxycycline, culture and susceptibility testing are recommended.
Doxycycline is indicated for treatment of infections caused by the following gram-negative bacteria, when bacteriologic testing indicates appropriate susceptibility to the drug:
Escherichia coli .
Enterobacter aerogenes .
Shigella species.
Acinetobacter species.
Respiratory tract infections caused by Haemophilus
influenzae .
Respiratory tract and urinary tract infections caused
by Klebsiella species.
Doxycycline is indicated for treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:
Upper
respiratory infections caused by Streptococcus pneumoniae .
Anthrax
due to Bacillus anthracis , including inhalational anthrax
(post-exposure): to reduce the incidence or progression of disease
following exposure to aerosolized Bacillus anthracis .
When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of the following infections:
Uncomplicated gonorrhea caused by Neisseria
gonorrhoeae .
Syphilis caused by Treponema pallidum .
Yaws caused by Treponema pallidum
subspeciespertenue .
Listeriosis due to Listeria monocytogenes .
Vincent's infection caused by Fusobacterium
fusiforme .
Actinomycosis caused by Actinomyces israelii .
Infections caused by Clostridium species .
In acute intestinal amebiasis, doxycycline may be a useful adjunct to amebicides.
In severe acne, doxycycline may be useful adjunctive therapy.
Prophylaxis
Doxycycline is indicated for the prophylaxis of malaria due to Plasmodium falciparum in short-term travelers (<4 months) to areas with chloroquine and/or pyrimethamine-sulfadoxine resistant strains. (SeeDOSAGE AND ADMINISTRATION
section and Information for Patients subsection of the
PRECAUTIONS
section.)