INDICATIONS AND USAGE
To reduce the development of drug-resistant bacteria and maintain the effectiveness of doxycycline tablets and other antibacterial drugs, doxycycline tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.Doxycycline is indicated for the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae.Respiratory tract infections caused by Mycoplasmapneumoniae.Lymphogranuloma venereum caused by Chlamydiatrachomatis.Psittacosis (omithosis) caused by Chlamydiapsittaci.Trachoma caused by Chlamydiatrachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence.Inclusion conjunctivitis caused by Chlamydiatrachomatis.Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydiatrachomatis. Nongonococcal urethritis caused by Ureaplasmaurealyticum. Relapsing fever due to Borreliarecurrentis. Doxycycline is also indicated for the treatment of infections caused by the following gram-negative microorganisms:Chancroid caused by Haemophilusducreyi. Plague due to Yersiniapestis (formerly Pasteurellapestis). Tularemia due to Francisellatularensis (formerly Pasteurellatularensis). Cholera caused by Vibriocholerae (formerly Vibriocomma). Campylobacter fetus infections caused by Campylobacterfetus (formerly Vibriofetus). Brucellosis due to Brucella species (in conjunction with streptomycin). Bartonellosis due to Bartonellabacilliformis. Granuloma inguinale caused by Calymmatobacteriumgranulomatis. Because many strains of the following groups of microorganisms have been shown to be resistant to doxycycline, culture and susceptibility testing are recommended.Doxycycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug:Escherichia coliEnterobacter aerogenes(formerly Aerobacter aerogenes) ShigellaspeciesAcinetobacter species(formerly Mima species and Herellea species) Respiratory tract infections caused by Haemophilus influenzae. Respiratory tract and urinary tract infections caused by Klebsiella species. Doxycycline is indicated for treatment of infections caused by the following grampositive microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug: Upper respiratory infections caused by Streptococcus pneumoniae (formerly Diplococcuspneumoniae). Skin and skin structure infections caused by Staphylococcus aureus. Anthrax due to Bacillusanthracis, including inhalational anthrax (post-exposure); to reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis. Doxycycline is not the drug of choice in the treatment of any type of staphylococcal infections.When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of the following infections:Uncomplicated gonorrhea caused by Neisseria gonorrhoeae. Syphilis caused by Treponema pallidum. Yaws caused by Treponema pertenue. Listeriosis due to Listeria monocytogenes. Vincents infection caused by Fusobacteriumfusiforme. Actinomycosis caused by Actinomycesisraelii. Infections caused by Clostridium species. In acute intestinal amebiasis, doxycycline may be a useful adjunct to amebicides.In severe acne, doxycycline may be useful adjunctive therapy.