1 INDICATIONS AND USAGE
HUMIRA is a tumor necrosis factor (TNF) blocker indicated for:
Rheumatoid Arthritis (RA)(
1.1
):reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients withmoderately to severely active RA.
Juvenile Idiopathic Arthritis (JIA)(
1.2
):reducing signs and symptoms of moderately to severely active polyarticular JIA in patients 2 years of age and older.
Psoriatic Arthritis (PsA)(
1.3
):reducing signs and symptoms, inhibiting the progression of structural damage, and improving physical function in adult patients with active PsA.
Ankylosing Spondylitis (AS)
(
1.4
):reducing signs and symptoms in adult patients with active AS.
Crohns Disease (CD)(
1.5
):treatment of moderately to severely active Crohns disease in adults and pediatric patients 6 years of age and older.
Ulcerative Colitis (UC)(
1.6
):treatment of moderately to severely active ulcerative colitis in adults and pediatric patients 5 years of age and older.
Limitations of Use:Effectiveness has not been established in patients who have lost response to or were intolerant to TNF blockers.
Plaque Psoriasis (Ps)(
1.7
):treatment of adult patients with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy, and when other systemic therapies are medically less appropriate.
Hidradenitis Suppurativa (HS)(
1.8
):treatment of moderate to severe hidradenitis suppurativa in patients 12 years of age and older.
Uveitis (UV)(
1.9
):treatment of non-infectious intermediate, posterior, and panuveitis in adults and pediatric patients 2 years of age and older.
1.1 Rheumatoid Arthritis
HUMIRA is indicated for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active rheumatoid arthritis. HUMIRA can be used alone or in combination with methotrexate or other non-biologic disease-modifying anti-rheumatic drugs (DMARDs).
1.2 Juvenile Idiopathic Arthritis
HUMIRA is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in patients 2 years of age and older. HUMIRA can be used alone or in combination with methotrexate.
1.3 Psoriatic Arthritis
HUMIRA is indicated for reducing signs and symptoms, inhibiting the progression of structural damage, and improving physical function in adult patients with active psoriatic arthritis. HUMIRA can be used alone or in combination with non-biologic DMARDs.
1.4 Ankylosing Spondylitis
HUMIRA is indicated for reducing signs and symptoms in adult patients with active ankylosing spondylitis.
1.5 Crohns Disease
HUMIRA is indicated for the treatment of moderately to severely active Crohns disease in adults and pediatric patients 6 years of age and older.
1.6 Ulcerative Colitis
HUMIRA is indicated for the treatment of moderately to severely active ulcerative colitis in adults and pediatric patients 5 years of age and older.
Limitations of Use
The effectiveness of HUMIRA has not been established in patients who have lost response to or were intolerant to TNF blockers [see Clinical Studies (
14.7
,
14.8
)].
1.7 Plaque Psoriasis
HUMIRA is indicated for the treatment of adult patients with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy, and when other systemic therapies are medically less appropriate. HUMIRA should only be administered to patients who will be closely monitored and have regular follow-up visits with a physician [see Warnings and Precautions
(
5
)
].
1.8 Hidradenitis Suppurativa
HUMIRA is indicated for the treatment of moderate to severe hidradenitis suppurativa in patients 12 years of age and older.
1.9 Uveitis
HUMIRA is indicated for the treatment of non-infectious intermediate, posterior, and panuveitis in adults and pediatric patients 2 years of age and older.