Calcium-activated potassium channel subunit alpha-1
Calcium-activated potassium channel subunit alpha-1 also known as large conductance calcium-activated potassium channel, subfamily M, alpha member 1 (K1.1), or BK channel alpha subunit, is a voltage gated potassium channel encoded by the KCNMA1 gene and characterized by their large conductance of potassium ions (K+) through cell membranes. Function. BK channels are activated (opened) by changes in membrane electrical potential and/or by increases in concentration of intracellular calcium ion (Ca). Opening of BK channels allows K to passively flow through the channel, down the electrochemical gradient. Under typical physiological conditions, this results  in an efflux of K from the cell, which leads to cell membrane hyperpolarization (a decrease in the electrical potential across the cell membrane) and a decrease in cell excitability (a decrease in the probability that the cell will transmit an action potential). BK channels are essential for the regulation of several key physiological processes including smooth muscle tone and neuronal excitability. They control the contraction of smooth muscle and are involved with the electrical tuning of hair cells in the cochlea. BK channels also contribute to the behavioral effects of ethanol in the worm "C. elegans" under high concentrations  (> 100 mM, or approximately 0.50% BAC). It remains to be determined if BK channels contribute to intoxication in humans. Structure. BK channels have a tetrameric structure. Each monomer of the channel-forming alpha subunit is the product of the KCNMA1 gene. Modulatory beta subunits (encoded by KCNMB1, KCNMB2, KCNMB3, or KCNMB4) can associate with the tetrameric channel. Alternatively spliced transcript variants encoding different isoforms have been identified. Each BK channel alpha subunit consists of (from N- to C-terminal): Available X-ray structures include: Pharmacology. BK channels are pharmacological targets for the treatment of stroke. Various pharmaceutical companies developed  synthetic molecules activating these channels in order to prevent excessive neurotoxic calcium entry in neurons. But BMS-204352 (MaxiPost) a molecule developed by Bristol-Myers Squibb failed to improve clinical outcome in stroke patients compared to placebo. BK channels have also been found to be activated by exogenous pollutants and endogenous gazotransmitters carbon monoxide and hydrogen sulphide. BK channels are blocked by tetraethylammonium (TEA), paxilline and iberiotoxin. Related conditions. Researchers have identified a rare disease in humans caused by mutations in the gene.  KCNMA1-linked channelopathy can cause neurological conditions like seizures and movement disorders. An episode of the Diagnosis TV  show, based on a column in the New York Times, was about a young girl with a KCNMA1 disorder that caused transient episodes of muscle weakness.