The 18th part of my serial about my childhood. We have come to the high school when I started in seventh grade. This part will surprise you, which it did for me when it happened. Some samples of tubules revealed calcification in all groups, but it was not statistically significant. Extensive apoptosis, especially in CsA group, was remarkable in tubule epithelial cells. The treatment group had a substantial decrease in apoptosis. (p=0.006) (Table 4). Masson trichrome stain was used for the evaluation of interstitial fibrosis. Nevertheless, it was not detected in any samples. There were not interstitial vacuolization, wall thickening of arteries and arterioles, hyaline deposition, and lumen contraction. Osteopontin (OSP) showed strong positivity especially in the CsA group. Granular cytoplasmic staining of OSP was observed in tubules and medullary regions. OSP density was lower in the treatment group. Moreover, the OSP staining was different between cyclosporine and the treatment groups and statistically significant (p=0.04) (Table 4).