the rats were randomly allocated into five groups, included six rats in each group. pharmaceutical forms of each drug were administrated to animals by subcutaneous route for 21 days. 2 ml of saline was administered to group 1; 25 mg/kg/day csa was administered to group 2; 25 mg/kg/day csa and 4 mg/kg/day carvedilol were administered to group 3; 25 mg/kg/day csa and 10 mg/kg/day atorvastatin were administered to group 4; 25 mg/kg/day csa, 4 mg/kg/day carvedilol and 10 mg/kg/day atorvastatin were administered to group 5. on day 22, all animals were anesthetized with 40 mg/kg intraperitoneal ketamine hydrochloride (ketalar flakon, 45 mg/kg, pfizer, istanbul, turkey) and blood samples were obtained by intracardiac way for determination of renal functions. the subjects were sacrificed after the kidneys had been removed. left kidney was stored at --80°c for enzymatic analysis and the right kidney was placed into 10% formalin solution for histopathological evaluation.