Dancing Lessons for the Advanced in Age. Softberry's FGenesH predicts two upstream promoters, a TATA Box 461bp upstream of the start site and another uncharacterized promoter 83bp upstream. Genomatix ElDorado predicts several transcription factor binding sites in the promoter region. found that Fam158a expression increases in GATA3 mutants, and as seen in the table, the Fam158a promoter region contains a Gata binding site. Another study shows FAM158A responds to Beta-catenin depletion. Although there are no known beta-catenin binding sites in the promoter, there is a NeuroD site and NeuroD responds to beta-catenin. Homology. Paralogs. The paralog to FAM158A is commonly known as Cox4NB 	Fam158a
6146830	and is located at 16q24. It is also referred to as Cox4AL, Noc4, and Fam158b. The paralog partially overlaps COX4I1 and has two isoforms. Isoform 1 is the complete isoform at 210 amino acids while isoform 2 is 126 amino acids. Like Fam158a, Cox4NB is highly conserved in Eukaryotes from mammals to as far back as fish. Currently there is no known function of Cox4NB. In most fish and further back there is a single homolog, the predecessor to Cox4NB and Fam158a. Homologs. As shown in the alignment, the protein is highly conserved chemically, although the exact sequence varies. There 	Fam158a
6146831	are also several regions of high conservation (highlighted by the red boxes). The degree of conservation follows the expected evolutionary pattern. The graph demonstrates this by plotting each species protein similarity to the human protein vs. the time since the species shared a common ancestor. The unrooted phylogenetic tree also demonstrates this relationship. Protein. Fam158a has an isoelectric point of 5.5 and a molecular weight of 23 kiloDaltons. Fam158a does not have any predicted signal peptides or transmembrane regions. There are several predicted phosphorylation sites. marked in the conceptual translation as well as the predicted secondary structure. There are no 	Fam158a
6146832	regions significantly different from other human proteins with regard to composition, regions of polarity, or regions of hydrophobicity. iPsortII predicts no signal peptides and localizes Fam158a to the cytoplasm- I-Tasser predicts several structures for Fam158a and the best prediction is shown. Swiss Model predicts two potential protein structures, as seen in the images. The first structure predicts the protein forms a protein dimer, the second as a monomer. Rual et al. found that Fam158a interacts with a protein called TTC35. The function of TTC35 is unknown but it is also known to interact with Cox4NB and Ubiquitin C. Function	Fam158a
6146833	. Fam158a is nearly ubiquitously expressed throughout the human body. The homolog in mice also shows expression throughout the entire body. Several micro-arrays demonstrate the variable expression of Fam158a in response to other factors and in various cancer types. None of this information gives any indication of a specific function but the wide expression of the gene and its high conservation indicate that Fam158a plays an important role in cellular function. Clinical significance. There are several diseases associated with deletions of 14q11.2, but none have been linked specifically to Fam158a. T-Lymphocytic Leukemia with or without ataxia telangiectasia has been 	Fam158a
6146834	associated with inversions and tandem translocations of 14q11 and 14q32 and other chromosomes. Also, syndactyly type 2 has been isolated to 14q11.2-12. This form of syndactyly is characterized by fusion of the third and fourth digits of the hand and the fourth and fifth digits of the foot in addition to other fusions and malformations. Fam158a UPF0172 protein FAM158A, also known as c14orf122 or CGI112, is a protein that in humans is encoded by the FAM158A gene located on chromosome 14q11.2. Human FAM158A and its paralogs in other species are part of the uncharacterized protein family UPF0172 family, which 	Fam158a
6146835	Tutli Tutli Tutli () may refer to: Tutli Tutli () may refer to: 	Tutli
6146836	Dancing Lessons for the Advanced in Age Dancing Lessons for the Advanced in Age Dancing Lessons for the Advanced in Age () is a 1964 novel by the Czech writer Bohumil Hrabal. It tells the story of a man who recounts various events from his past, and in particular his love life. The novel is written in one long sentence. Reception. The book was reviewed in Publishers Weekly" in 1995, where the critic described it as a "humorous and breathless affair". The review continued: "Hrabal, who has been cited as a major literary influence by Milan Kundera and Ivan Klima, among others, is generally considered the most revered  living Czech author. It's easy to see why. As this novel (originally published in Czech in 1964) plays around with Czech history, juxtaposing the public life of the country with the private life of the narrator, Hrabal displays abounding energy and a rambunctious wit." Howard Norman of the "Los Angeles Times" wrote that it "stands up to the best of Hrabal", and argued that his novels "distill complicated human behavior to its basic--albeit at times repugnant, at times joyful--motivations". Dancing Lessons for the Advanced in Age Dancing Lessons for the Advanced in Age () is a 1964 novel