COASY
Bifunctional coenzyme A synthase is an enzyme that in mammals is encoded by the "COASY" gene that catalyses the synthesis of coenzyme A from 4'-phosphopantetheine. Function. COASY is an enzyme that catalyzes the last two steps in the synthesis of coenzyme A from vitamin B (pantothenic acid). The primary substrate is 4'-phosphopantetheine and COASY is a bifunctional enzyme in this pathway: In mammals this is a single enzyme, but in organsims including yeast and bacteria these enzymes are encoded by separate genes. Interactions. COASY has been shown to interact with P70-S6 Kinase 1. In 2009, COASY has also  been implicated in PI3K signaling, as it was shown to interact with a regulatory subunit of PI3K. Clinical significance. Loss of function mutations to "COASY" have been associated with an ultra-rare disease that causes neurodegeneration with brain iron accumulation called COASY protein-associated neurodegeneration (CoPAN), or NBIA6.