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13-Feb-2016, 07:45 UT/GMT Key molecule that blocks abnormal blood vessel growth in tumors identified	Posted ScienceDaily (Sep. 21, 2011)  A new and better understanding of blood vessel growth and vascular development (angiogenesis) in cancer has been made possible by research carried out by a team of scientists from Moffitt Cancer Center, the University of Florida, Harvard University, Yale University and the Children’s Hospital of Los Angeles.
“Vascular development is a fundamental biological process that is tightly controlled by both pro-and anti-angiogenic mechanisms,” said Edward Seto, Ph.D., a co-author of the study and professor and chairman of the Department of Molecular Oncology at Moffitt. “Physiological angiogenesis occurs in adults only under specific settings. Excess angiogenesis contributes to a variety of diseases, including cancer. In cancer, vascular endothelial growth factor (VEGF) is commonly overproduced.”
“Understanding the biological principles that direct vascular growth has important clinical implications because cancers are highly vascularized,” concluded Seto.
“At the heart of vascular development is VEGF which, in precise doses, is an important stimulator of normal blood vessel growth,” explained Seto. “However, VEGF — probably the most important stimulator of normal and pathological blood vessel growth — is regulated by a number of factors.”
“The real significance of this work has been apparent in experiments done at the University of Florida and at Harvard University, where our colleagues used mouse models to demonstrate that depletion of CTCF produces excess angiogenesis in animals,” explained Seto. “Like finding a small key piece in a giant puzzle, it’s truly exciting.”
The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by H. Lee Moffitt Cancer Center Research Institute. Journal Reference: