Carl Wernicke
Carl (or Karl) Wernicke (; ; 15 May 1848 – 15 June 1905) was a German physician, anatomist, psychiatrist and neuropathologist. He is known for his influential research into the pathological effects of specific forms of encephalopathy and also the study of receptive aphasia, both of which are commonly associated with Wernicke's name and referred to as Wernicke encephalopathy and Wernicke's aphasia, respectively. His research, along with that of Paul Broca, led to groundbreaking realizations of the localization of brain function, specifically in speech. As such, Wernicke's area (a.k.a. Wernicke's Speech Area) has been named after the  scientist. Biography. Wernicke was born on May 15, 1848 in Tarnowitz, a small town in Upper Silesia, Prussia, now Tarnowskie Góry, Poland. He obtained his secondary education at the gymnasium in Oppeln, which is a school near the university of Breslau. Wernicke then studied medicine at the University of Breslau and did graduate work studying language and aphasia at Breslau, Berlin, and Vienna. After he earned his medical degree at the University of Breslau (1870), he worked in Breslau at Allerheiligen Hospital as an assistant to an ophthalmology professor Ostrid Foerster for six months. Unfortunately in 1870, the Franco-Prussian  War broke out, where Wernicke served as an army surgeon. After serving in the war, he returned to the Allerheiligen Hospital and worked in the psychiatric department as an assistant under Professor Heinrich Neumann. Neumann sent him to Vienna for six months to study with neuropathologist Theodor Meynert, who would have a profound influence upon Wernicke's career. In 1875, Wernicke was appointed the first assistant in the Berlin Charite clinic under Karl Westphal, where he stayed until 1878 studying psychiatry and nervous diseases. In 1878 Wernicke founded a private neuropsychiatric practice in Berlin and published numerous articles until he  left the practice in 1881. In 1885, he succeeded his mentor Professor Neumann and served as associate professor of neurology and psychiatry at Breslau, where he also attained a conference chair. By 1890 Wernicke became the director of the psychiatric wing at the Allerheiligen Hospital, and he also became head of the University Hospital's Department of Neurology and Psychiatry. In 1904, Wernicke worked at the University of Halle, heading its Psychiatry and Neurology Clinic. Wernicke died on June 15, 1905 due to injuries suffered from a bicycle accident in the Thuringian Forest. Studies in aphasia. Wernicke was heavily inspired  by the research on language and communication coming from Paris, France, specifically from Paul Pierre Broca. Broca's work on motor aphasia influenced Wernicke's interests in psychophysiology and aphasiology relating to language. Wernicke began to question the relationship between dysphasia and the location of lesions that caused brain damage resulting in language problems. While studying with Mynert in 1874, Wernicke published "Der Aphasische Symptomencomplex". In his book, Wernicke described sensory aphasia, which is now known as Wernicke's aphasia, as being distinctly different from motor aphasia, described by Broca. He categorized sensory aphasia as fluent but disordered speech, impaired  understanding of speech, and impaired silent reading. Incorporating Broca's findings on motor aphasia, Wernicke described both forms of aphasia as being results of brain damage. However, the location of damage determined which aphasia a patient developed. He described sensory aphasia as a result from lesions to the left temporal lobe and motor / Broca's aphasia as a result from lesions to the left posterior frontal lobe. These two concepts were the foundation for his theory on the neural bases of language. Wernicke hypothesized that motor activity was accompanied by sensory stimulation and that there were fibers connected the motor  and sensory cortexes in the brain, so there must also be a connection between the lesioned areas contributing to sensory and motor aphasia. He discussed the problems with severing this connection, assuming both structures remain intact. The area affecting sensory aphasia would still function, so a patient could hypothetically retain comprehension of oral speech and silent reading. However, the connection to Broca's area would be broken, causing prevention of effective translation of mental processes into verbal speech. Wernicke additionally discussed the dangers of mistaking sensory aphasia with a confused or psychotic state, and he emphasized the importance of distinguishing  between aphasia and agnosia, the failure to recognize objects, which was described by Sigmund Freud in 1891. Wernicke proposed a theory of localization and suggested that different identifiable regions of the brain control different behaviors and these areas interact to produce more behaviors. This is the case with Broca's and Wernicke's areas interacting to produce language. Broca and Wernicke's work paved the way for others to study and identify localized areas of the brain, including the identification of the motor homunculus as well as the theory that brain damage in specific areas is responsible for different disorders , diseases, and abnormal behaviors. Ludwig Lichtheim, a Professor of Medicine at Bern University Hospital, wrote his work "Über Aphasie," which was influenced by Broca, Wernicke and Adolf Kussmaul. Lichtheim's work analyzed language abilities and categorized language disorders into seven different aphasias, Wernicke's aphasia being one of them. Wernicke then adopted Lichtheim's aphasia classification and became the Wernicke-Lichtheim model. The Elementary Symptom. At the 59th Breslau conference in 1892, Karl Kahlbaum described paranoia based on a case study that Wernicke was familiar with. Wernicke described the case study as an example of what he called the "elementary  symptom," which is the notion that there is a single, fundamental symptom and all other symptoms are derived from the elementary symptom. Karl Leonhard also followed Wernicke's studies. Although Leonhard rejected the "elementary symptom" theory because it overgeneralizes symptoms of disorders, he did incorporate Wernicke's psychopathological categories of disorders into Emil Kraepelin's binary system of classification. For example, Leonhard renamed Wernicke's "anxiety-psychosis" as "cycloid psychosis," which does resemble schizophrenia and Bipolar cycling. Kraepelin also rejected the elementary symptom theory by describing all of the clinical aspects of a particular disorder (nosology) in contrast to Wernicke 's theory, which attempted to home in on the key symptom instead of looking at each disorder as a whole. The theory of elementary symptom was generally rejected and is not a well-known concept today because of the lack of supporting evidence for the theory. Although the theory itself is not supported in modern nosology and etiology, it does have a general influence in psychopharmacology practices with its notion of a target symptom. Clinical psychopharmacology typically treats particular symptoms instead of disorders and diagnoses as a whole. Modern psychiatry does rest on assumptions that some symptoms result from other  symptoms, parallel to Wernicke's theory. Wernicke himself did not pursue research on the elementary symptom theory because of his devotion to aphasiology. One of the fundamental problems with the elementary symptom theory is that Wernicke described anxiety as the elementary symptom of many disorders. This was problematic for the theory because anxiety, to some extent, is seen in almost all psychiatric disorders. This caused the elementary symptom to fail at categorizing clinical descriptions and proper treatments. Another difficulty for Wernicke and other psychologists was determining which symptom was the elementary symptom and given priority over other symptoms that might  be just as important to treat and might not be a direct result of another symptom. Lastly, Wernicke preserved traditional German psychiatry and described clinical vignettes, being unable to distinguish between physical and psychological causes of symptoms instead of using Kraepelin's approach of delineation of syndromes and disorders. Publications. In 1897, with Theodor Ziehen (1862-1950), he founded the journal "Monatsschrift für Psychiatrie und Neurologie". Conference proceedings from Breslau were published in the "Allgemeine Zeitschrift fur Psychiatrie und Psychische-Gerichtliche Medizin". Principal written works by Wernicke include: