SCN1B
Sodium channel subunit beta-1 is a protein that in humans is encoded by the "SCN1B" gene. Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM] Clinical significance. Mutation in the SCN1B gene are associated with disorders such as Brugada syndrome and GEFS. SCN1B