Hoodia
Hoodia (; known locally as "ghaap" or "bobbejaanghaap") is a genus of flowering plants in the family Apocynaceae, under the subfamily Asclepiadoideae, native to Southern Africa. One species of "Hoodia" in particular, "Hoodia gordonii", has achieved a degree of fame and controversy, after being investigated for use as a possible appetite suppressant. Description. The group was first described as a genus in 1844. Hoodia are stem succulents, described as "cactiform" because of their remarkable similarity to the unrelated cactus family. They have a branching, shrub-like form, and the largest species ("Hoodia parviflora") can grow to the size of a  tree — over in height. The flowers are extremely variable in size — from less than 1 cm, to almost 20 cm in diameter, depending on the species. Flowers appear in large numbers, always near the tops of the stems. Those of larger-flowered species (such as "Hoodia gordonii") are often a papery pink-tan colour, plate-shaped, with an unpleasant smell to attract their fly pollinators. The smaller, darker flowers of some species have a far stronger and more unpleasant smell than the larger flowers. Distribution. The genus "Hoodia" is restricted to the arid regions in the western part of southern  Africa, ranging from western South Africa to central Namibia and as far north as southern Angola. It is especially common in the Namib desert and in the Orange River valley. Typical habitat is rocky slopes and open stone plains. Plants usually germinate in the shelter of bushes or rocks, but survive in the open as adult plants. Several of the small-flowered species of "Hoodia" were formerly in a separate genus, "Trichocaulon" ("ghaap"), but have been moved into the genus "Hoodia", and the two groups are now synonymous. Phylogenetic studies have shown the genus "Hoodia" to be monophyletic, and most  closely related to the stapeliad genus "Lavrania". Marginally more distantly related is a sister branch of related genera including "Larryleachia", "Richtersveldia" and "Notechidnopsis". Uses and horticulture. Supplement. "Hoodia gordonii" is traditionally used by the San people (Bushmen) of the Namib desert as an appetite suppressant as part of their indigenous knowledge about survival in the harsh desert conditions. In 2006, the plant became internationally known, after a marketing campaign falsely claimed that its use as a dietary supplement was an appetite suppressant for weight loss. As of 2018, there is no high-quality clinical research showing that hoodia has actions  as an appetite suppressant or is effective for weight loss. In a case of biopiracy, bioprospectors from South Africa’s Council for Scientific and Industrial Research (CSIR) realized that the plant was marketable and patented its use as an appetite suppressant without recognizing the Sans' traditional claims to the knowledge of the plant and its uses. The patent was later sold to Unilever, which marketed hoodia products as diet supplements. In 2003, the South African San Council entered into a benefit sharing agreement with CSIR in which they would receive from 6 to 8% of the revenue from the sale  of "Ho. gordonii" products, money which would be deposited in a trust for all San peoples across Southern Africa. Horticulture. Several species are grown as garden plants, and one species, "H. gordonii", is being investigated for use as an appetite suppressant. However, in 2008, UK-based Unilever PLC, one of the largest packaged-food firms in the world, abandoned plans to use hoodia in a range of diet products. In a document on Unilever's website entitled "Sustainable Development 2008: An Overview", signed by Paul Polman, CEO, Unilever states: "During 2008, having invested 20 million [pounds] in R&D, Unilever abandoned  plans to use the slimming extract hoodia in a range of diet products. We stopped the project because our clinical studies revealed that products using hoodia would not meet our strict standards of safety and efficacy." Many "Hoodia" species are protected plants. "Hoodia" is currently listed in Appendix II to the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), which includes species not currently considered endangered but are at risk if trade is not controlled.