Interferon-induced transmembrane protein 5
Interferon-induced transmembrane protein 5 is a gene that encodes a membrane protein thought to play a role in bone mineralization. Genomics. The gene is located on the short arm of the Crick strand of chromosome 11 (11p15.5). It is located with a cluster of interferon inducible genes but is itself not interferon inducible. The gene is 1,327 bases in length and encodes a protein of 132 amino acids with a predicted molecular weight of 14378 Daltons. Expression in adults is bone specific and highest in osteoblasts. The homolog in the mouse is located on  chromosome 7. A homolog is also known to be present in lizards. Evolution. The gene first appeared in bony fish and its bone specific expression appears to be limited to therian mammals. Biochemistry. The protein has two transmembrane domains. It associates with FK506 binding protein 11. Clinical. Mutations in the gene are associated with osteogenesis imperfecta type 5. References. __notoc__