Mowat–Wilson syndrome during his commentary broadcasts. Dave Loveridge David Steven Loveridge (born 22 April 1952) is an All Black of the late 1970s and early 1980s, known in his time as the greatest halfback in the world. Life and career. Loveridge was born in 1952, in Stratford, New Zealand, to Horace and Margaret Loveridge. He grew up during the golden age of Taranaki rugby, with the provincial side holding the Ranfurly Shield for two tenures in 1957–1959, and 1963–1965. He played age-grade representative rugby for Taranaki at the age of 12. The Loveridge family owned a pig farm in Tariki south 	Dave Loveridge
448963	Mowat–Wilson syndrome Mowat–Wilson syndrome Mowat–Wilson syndrome is a rare genetic disorder that was clinically delineated by David R. Mowat and Meredith J. Wilson in 1998. Presentation. This autosomal dominant disorder is characterized by a number of health defects including Hirschsprung disease, intellectual disability, epilepsy, delayed growth and motor development, congenital heart disease, genitourinary anomalies and absence of the corpus callosum. However, Hirschsprung's disease is not present in all infants with Mowat–Wilson syndrome and therefore it is not a required diagnostic criterion. Distinctive physical features include microcephaly, narrow chin, cupped ears with uplifted lobes with central depression, deep and 	Mowat–Wilson syndrome
448964	widely set eyes, open mouth, wide nasal bridge and a shortened philtrum. People with this condition have severe intellectual disability in almost all cases, however, a small minority have moderate intellectual disability. Speech is typically limited or absent. Many of those with Mowat–Wilson syndrome also have a distinctive open mouthed, smiling expression and friendly personalities. Causes. The disorder is expressed in an autosomal dominant fashion and may result from a de novo" loss of function mutation or total deletion of the "ZEB2" gene located on chromosome 2q22. Diagnosis. Mowat–Wilson syndrome (MWS) can be diagnosed clinically on the basis  of moderate to severe intellectual disability in the presence of characteristic facial features (widely spaced eyes, broad eyebrows with a medial flare, low-hanging columella, prominent or pointed chin, open-mouth expression, and uplifted earlobes with a central depression — coined as orecchiette ears given their resemblance to the pasta). Other clinical features can include congenital heart defects, Hirschsprung disease or chronic constipation, genitourinary anomalies (particularly hypospadias in males), and hypogenesis or agenesis of the corpus callosum. Speech is typically limited to a few words or is absent, with relative preservation of receptive language skills. Growth restriction with microcephaly and seizure  disorder are also common. Most affected people have a happy demeanor and a wide-based gait that can sometimes be confused with Angelman syndrome. The diagnosis of MWS confirmed by demonstrating a pathogenic variant (mutation) in the "ZEB2" gene by molecular genetic testing. Treatment. To date, there is no cure for MWS. Affected individuals should see a pediatrician or adult physician at least annually to monitor growth, development, seizures and general health and well-being. Developmental potential is maximized through the use of physiotherapy, occupational therapy and speech pathology. Medical subspecialist care may be required if other organs are involved  (e.g., a cardiologist and/or cardiac surgeon for congenital heart disease, gastroenterologist and or surgeon for Hirschsprung's disease or constipation. Prognosis. There is no cure for this syndrome. Treatment is supportive and symptomatic. All children with Mowat–Wilson syndrome required early intervention with speech therapy, occupational therapy and physical therapy. Mowat–Wilson syndrome Mowat–Wilson syndrome is a rare genetic disorder that was clinically delineated by David R. Mowat and Meredith J. Wilson in 1998. Presentation. This autosomal dominant disorder is characterized by a number of health defects including Hirschsprung disease, intellectual disability, epilepsy, delayed growth and motor development, congenital