2021 Eastbourne International – Women's singles
Karolína Plíšková was the defending champion from when the event was last held in 2019, but she lost in the first round to Camila Giorgi. As a result, Plíšková fell out of the top 10 of the WTA rankings for the first time since September 2016. Jeļena Ostapenko won the title, defeating Anett Kontaveit in the final, 6–3, 6–3. Ostapenko became just the third wildcard to win the title at Eastbourne, following Monica Seles and Julie Halard-Decugis.