The functional capacity of individuals with CFS varies greatly. Some persons with CFS lead relatively normal lives; others are totally bed-ridden and unable to care for themselves, work, school, and family activities can be significantly reduced for extended periods of time with many people experiencing strongly disabling chronic pain leading to critical reductions in levels of physical activities. Symptoms are comparable to other fatiguing medical conditions including late-stage AIDS, lupus, rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), and end-stage kidney disease. CFS may also affect a person’s functional status and well-being more than major medical conditions such as multiple sclerosis, congestive heart failure, or type II diabetes mellitus. Often, People may feel better for a period and may overextend their activities, and the result can be a worsening of their symptoms with a relapse of the illness. People with CFS have decreased quality of life, with regard to vitality, physical functioning, general health, physical role and social functioning. Mental agility, Memory, reactions and cognitive functions may also be effected.