DUSP16
Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the "DUSP16" gene. The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM] Interactions. DUSP16 has been shown to interact with MAPK14 and MAPK8IP1.