Fluid mosaic model
The fluid mosaic model explains various observations regarding the structure of functional cell membranes. According to this biological model, there is a lipid bilayer (two molecules thick layer consisting primarily of amphipathic phospholipids) in which protein molecules are embedded. The phospholipid bilayer gives fluidity and elasticity to the membrane. Small amounts of carbohydrates are also found in the cell membrane. The biological model, which was devised by SJ Singer and G. L. Nicolson in 1972, describes the cell membrane as a two-dimensional liquid that restricts the lateral diffusion of membrane components. Such domains are defined by  the existence of regions within the membrane with special lipid and protein cocoon that promote the formation of lipid rafts or protein and glycoprotein complexes. Another way to define membrane domains is the association of the lipid membrane with the cytoskeleton filaments and the extracellular matrix through membrane proteins. The current model describes important features relevant to many cellular processes, including: cell-cell signaling, apoptosis, cell division, membrane budding, and cell fusion. The fluid mosaic model is the most acceptable model of the plasma membrane. Its main function is to separate the contents of the cell from the exterior. Chemical  makeup. Chemically a cell membrane is composed of four components: (1) Phospholipids (2) Proteins (3) Carbohydrates (4) Cholesterol Experimental evidence. The fluid property of functional biological membranes had been determined through labeling experiments, x-ray diffraction, and calorimetry. These studies showed that integral membrane proteins diffuse at rates affected by the viscosity of the lipid bilayer in which they were embedded, and demonstrated that the molecules within the cell membrane are dynamic rather than static. Previous models of biological membranes included the Robertson Unit Membrane Model and the Davson-Danielli Tri-Layer model. These models had proteins present as sheets  neighboring a lipid layer, rather than incorporated into the phospholipid bilayer. Other models described repeating, regular units of protein and lipid. These models were not well supported by microscopy and thermodynamic data, and did not accommodate evidence for dynamic membrane properties. An important experiment that provided evidence supporting fluid and dynamic biological was performed by Frye and Edidin. They used Sendai virus to force human and mouse cells to fuse and form a heterokaryon. Using antibody staining, they were able to show that the mouse and human proteins remained segregated to separate halves of the heterokaryon a short time after  cell fusion. However, the proteins eventually diffused and over time the border between the two halves was lost. Lowering the temperature slowed the rate of this diffusion by causing the membrane phospholipids to transition from a fluid to a gel phase. Singer and Nicolson rationalized the results of these experiments using their fluid mosaic model. The fluid mosaic model explains changes in structure and behavior of cell membranes under different temperatures, as well as the association of membrane proteins with the membranes. While Singer and Nicolson had substantial evidence drawn from multiple subfields to support their model, recent advances in  fluorescence microscopy and structural biology have validated the fluid mosaic nature of cell membranes. Subsequent developments. Membrane asymmetry. Additionally, the two leaflets of biological membranes are asymmetric and divided into subdomains composed of specific proteins or lipids, allowing spatial segregation of biological processes associated with membranes. Cholesterol and cholesterol-interacting proteins can concentrate into lipid rafts and constrain cell signaling processes to only these rafts. Another form of asymmetry was shown by the work of Mouritsen and Bloom in 1984, where they proposed a Mattress Model of lipid-protein interactions to address the biophysical evidence that the membrane can range  in thickness and hydrophobicity of proteins. Non-bilayer membranes. The existence of non-bilayer lipid formations with important biological functions was confirmed subsequent to publication of the fluid mosaic model. These membrane structures may be useful when the cell needs to propagate a non bilayer form, which occurs during cell division and the formation of a gap junction. Membrane curvature. The membrane bilayer is not always flat. Local curvature of the membrane can be caused by the asymmetry and non-bilayer organization of lipids as discussed above. More dramatic and functional curvature is achieved through BAR domains, which bind to  phosphatidylinositol on the membrane surface, assisting in vesicle formation, organelle formation and cell division. Curvature development is in constant flux and contributes to the dynamic nature of biological membranes. Lipid movement within the membrane. During the decade of 1970, it was acknowledged that individual lipid molecules undergo free lateral diffusion within each of the layers of the lipid membrane. Diffusion occurs at a high speed, with an average lipid molecule diffusing ~2 µm, approximately the length of a large bacterial cell, in about 1 second. It has also been observed that individual lipid molecules rotate rapidly around their own axis . Moreover, phospholipid molecules can, although they seldom do, migrate from one side of the lipid bilayer to the other (a process known as flip-flop). However, flip-flop might be enhanced by flippase enzymes. The processes described above influence the disordered nature of lipid molecules and interacting proteins in the lipid membranes, with consequences to membrane fluidity, signaling, trafficking and function. Restrictions to bilayer fluidity. There are restrictions to the lateral mobility of the lipid and protein components in the fluid membrane imposed by the formation of subdomains within the lipid bilayer. These subdomains arise by several processes "e.g." binding  of membrane components to the extracellular matrix, nanometric membrane regions with a particular biochemical composition that promote the formation of lipid rafts and protein complexes mediated by protein-protein interactions. Furthermore, protein-cytoskeleton associations mediate the formation of “cytoskeletal fences”, corrals wherein lipid and membrane proteins can diffuse freely, but that they can seldom leave. Restriction on lateral diffusion rates of membrane components is very important because it allows the functional specialization of particular regions within the cell membranes. Lipid rafts. Lipid rafts are membrane nanometric platforms with a particular lipid and protein composition that laterally diffuse, navigating on the  liquid bilipid layer. Sphingolipids and cholesterol are important building blocks of the lipid rafts. Protein complexes. Cell membrane proteins and glycoproteins do not exist as single elements of the lipid membrane, as first proposed by Singer and Nicolson in 1972. Rather, they occur as diffusing complexes within the membrane. The assembly of single molecules into these macromolecular complexes has important functional consequences for the cell; such as ion and metabolite transport, signaling, cell adhesion, and migration. Cytoskeletal fences (corrals) and binding to the extracellular matrix. Some proteins embedded in the bilipid layer interact with the extracellular matrix outside the cell , cytoskeleton filaments inside the cell, and septin ring-like structures. These interactions have a strong influence on shape and structure, as well as on compartmentalization. Moreover, they impose physical constraints that restrict the free lateral diffusion of proteins and at least some lipids within the bilipid layer. When integral proteins of the lipid bilayer are tethered to the extracellular matrix, they are unable to diffuse freely. Proteins with a long intracellular domain may collide with a fence formed by cytoskeleton filaments. Both processes restrict the diffusion of proteins and lipids directly involved, as well as of other interacting components of  the cell membranes. Septins are a family of GTP-binding proteins highly conserved among eukaryotes. Prokaryotes have similar proteins called paraseptins. They form compartmentalizing ring-like structures strongly associated with the cell membranes. Septins are involved in the formation of structures such as, cilia and flagella, dendritic spines, and yeast buds.