TAS2R1
Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the "TAS2R1" gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues. Expression and function. Extra-oral roles of TAS2Rs. Bitter taste receptors are expressed in taste  receptor cells, which organized into taste buds on the papillae of the tongue and palate epithelium. In addition, TAS2Rs were found to be expressed in extra-oral tissues, e.g. brain, lungs, gastrointestinal tract, etc. So far, less is known about their function however, for example it was shown that: Structure of TAS2R1 receptor. Based on a recent homology model from BitterDB several conserved motifs, which are counterparts to Class A GPCRs were found: Unlike in Class A GPCRs, in transmembrane helix 4 no DRY motif was found as well as position 6.50 is not conserved. Section::::"TAS2R1" gene. This gene encodes  a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. SNPs. In T2R1 two SNPs are known in R111H and R206W (dbSNP). Transcription Factors. So far, AML1a, AP-1, AREB6, FOXL1, IRF-7A, Lmo2, NF-E2, NF-E2 p45 were found as the top transcription factor binding sites by QIAGEN in the "TAS2R1" gene promoter. Mutagenesis data. Several mutations have been  shown to influence binding of a ligand to TAS2R1 (based on BitterDB): Ligands. Up to now, 39 ligands for T2R1 were identified in BitterDB, among them L-amino acids, peptides, humulones, small molecules etc.