Tectitethya crypta
Tectitethya crypta is a species of demosponge belonging to the family Tethyidae. Its classified family is characterized by fourteen different known genera, one of them being "Tectitethya". It is a massive, shallow-water sponge found in the Caribbean Sea. This sponge was first discovered by Werner Bergmann in 1945 and later classified by de Laubenfels in 1949. It is located in reef areas situated on softer substrates such as sand or mud. Oftentimes, it is covered in sand and algae. This results in an appearance that is cream colored/ gray colored; however, when the animal is washed free  of its sediment coverings, its body plan appears more green and gray. It's characterized with ostia peaking out of its body cavity, with the ability to abruptly open or close, changing its desired water flow rate through its mesohyl. This sponge is widely known for its contributions to the field of medicine as a source for potent nucleoside analogues used in treating H.I.V, Acute Myeloid Leukemia, pancreatic cancer, Ebola, and others. The nucleosides spongothymidine and spongouridine were isolated from this sponge, providing the basis for anti-viral drugs and anti-cancer drugs. Vidarabine, an antiviral drug, was derived from  these compounds. The discovery of these nucleosides also led to the development of cytarabine for clinical use in the treatment of leukemia and lymphoma. Gemcitabine, a fluorinated derivative of cytarabine, is used to treat pancreatic, breast, bladder, and non-small-cell lung cancer. Holding such valuable compounds, free-living within the animal, "T. crypta" has shaped the present and future world of medicine. Anatomy & Physiology. Body Morphology. As described by Laubenfels, the body of this sponge is amorphous, bulky, and approximately the size of one's fist. It's dimensions are around 4x7x12cm and may be cylindrical, conical, or  hemispherical in shape. More recent studies have indicated a larger range of size within this species. The outermost, visible layer of the animal can be seen to have flat tubercules, approximately 3 to 5 millimeters in diameter and a thick layer of sediment. Its actual olive pigment isn't easily visible under this layer of sand/ sediment. In clustered bundles on the surface of the animal are structures called megascleres, radiating and branching outwards. Ray tips are rounded; micrasters are seen to be 8 to 12 micrometers in diameter. Star spicules makeup a layer beneath its exterior skeleton. "T. crypta  is not characterized with a cortex. Size. Three main developmental phases have been identified in conjunction with the sponges' localization of course sediment within its body. The small sponges are characterized with a spherical shape and possess evenly spread sediment. The medium T. crypta" sponges are seen to have a conical shape with their sediment concentrated near their bottom or base. The larger sponges are seen to be irregular in shape and also have evenly distributed sediments. With each body size are different habits that each acquire. Smaller sponges are unattached and are seen to rest and roll freely. The  medium sponges are also unattached; however, they still have great stability with their shape and sediment concentration. Lastly, the larger sponges are attached on their bottom-end. Typically, 67% of their body is buried in sand. Movement. "T. crypta" are capable of strong body contractions and allow oscula the ability to move (open/ close) at a quick rate. In fact, this sponge is capable of closing its osculum completely, which has been proven to be a useful adaptation for an animal living in sandy environments. Ostia are about 1 millimeter in size, occurring in clusters along the flank of the  sponge. The osculum, bearing a diameter of 20 to 25 millimeters, are seen near the top of the cone. These structures have the ability to be contracted. The ability to circulate water through bottom sediments possibly makes for a nutrient-rich and attractive environment for other organisms to live in or near the sponges. Sediment Organization. The dirty exterior of the sponge smothered in layers of algae/ sediment/ sand serves a purpose to the animal and has been shown to hold structural organization across its species. Sand that is brought into the body will be organized in patterns determined by  its granulometry and sponge size. This sorting and distribution occur in the choanosome: sediments smaller than 500 micrometers gather in clusters (known as nuclei) while the larger particles are found to be distributed evenly through the sponge body. "T. crypta" sponges have been noted to favor the selection of fine sediment grains within the range of 40 to 60 micrometers. Additional analysis through microscopic tools has revealed high selection for allocthonous sponge spicules, radiolarians, and diatoms. Deeper analysis of incorporated sediment is needed to identify additional materials and cells that have not been identified as of now. The sand is  eventually transported by a specific cell to a desired location through the use of a cellular track which facilitates sediment transport from the ectosome to the accumulated nuclei. The ontogeny of the "T. crypta" sponge is largely affected by this process of sediment incorporation and organization. Differentiation between smaller and larger sediments and their corresponding location has proven useful in identifying possible functioning of positioning of these particles on the surface of the sponge. Smaller, fine sediments are packed in the nuclei within the body of the sponge while the more coarse grains are located towards the base of the  sponge; this localization helps in anchoring and stabilizing the sponge with the help of gravity. The sediments are involved in part with the morphogenesis of the animal. The forming of the nuclei clusters stabilizes the sponge's body, allowing the animal to alter its skeleton structure. A radial morphology is then able to change into a branched one, which further allows the animal to develop into its massive, irregular fully-formed shape. Feeding. "T. crypta" are filter feeders, utilizing their choanocytes to generate an inward current and pulling in their nutrients. The course of action of filter feeding goes as  follows: ostium, spongocoel, and osculum. In the middle of this route, nutrients may be absorbed and taken in by the sponge to utilize. "T. crypta" generally eat the following organisms: Chaetoceros, pinnulaira, striatella unipunctata, and skeleronema tropicum. Reproduction. "T. crypta" reproduction may be oviparous through the use of parenchymella larvae or it may be carried out asexually (budding). Ecology. "Tectitethya crypta" can be found in shallow water, only about 1 to 20 meters in depth within the Caribbean. It dwells on a soft substrate, typically substances such as muds, sands, or clays. It can geographically be located in a reef  near the Florida Keys, Dry Tortugas, and north-west shores of Cuba, as well as the Florida west coast. The larger of the sponges, sizing around 1.5-10 liters in volume are typically found attached to their substrate while the smaller sponges of this species, sizing around 0.5-1.5 liters in volume are typically found to be unattached and resting freely on their bottom. Human Relations. Medicine. The discovery of T. crypta allowed for the discovery of the first sponge-derived pharmaceutical drugs. The two nucleosides, spongothymidine and spongouridine, are documented as the two nucleoside analogues used in the synthesis  of life-saving drugs today. These are natural products - not artificially synthesized. Marine natural products (MNP's) have been shown to have stronger bioactive properties than those from terrestrial organisms, possessing cytotoxic and antiproliferative agents. Understanding this has allowed scientists to recognize the role that these potent chemicals may play in chemical defense mechanisms and protection from prey. This may be the case for "T. crypta", as it's a sessile organism not possessing an immune system. The treatment of leukemia through the use of Ara-C (cytarabine) is the first documented anticancer agent that has come about from the  sponge. In fact, it was approved by the FDA in 1969 in treating non-Hodgkin's lymphoma and myeloid and myelocytic leukemia. As of today, cytarabine is one of the greatest contributors towards anti-cancer therapies. The drug disables Deoxyribonucleic Acid Polymerase, inhibiting DNA synthesis during the S phase of the cell cycle. This discovery allowed for scientists to manipulate the replication of viral DNA within its host and put a complete halt in its division. This hallmark discovery led to the development of azidothymidine (AZT) through the use of Ara-A. Azidothymidine is utilized in the treatment of HIV -infected individuals. Vidarabine (Ara-A) alone is used in ophthalmologic applications today. A fluorinated derivative of Ara-C has contributed towards the advancement of treatment for lung, pancreatic, breast, and bladder cancer. This drug is known as Gemcitabine - proven useful in its effectiveness against more "solid" tumors such as these. Manipulation of these two original nucleoside analogues provided by T. crypta has provided scientists and medical professionals the capability to offer humans potential cures to devastating diseases - and has inspired the future of medicine to search for "natural" cures in the sea.