I-tissue necrosis (gangrene). Kubonakala ngezigaba zokugcina zenqubo. Njengoba lesi sifo sikhula ngokushesha, isigaba singase siqale ngokushesha. A group of researchers has elucidated how a gene named Ly6/Plaur domain containing 8 (Lypd8) inhibits bacterial invasion of colonic epithelia, regulating intestinal inflammation. This achievement may lead to the development of drugs for ulcerative colitis. Meet at a dog park: For a casual and quick first date, suggest meeting with your dogs at the local dog park. You and your dogs can get exercise while playing a game of catch. Meeting at the dog park keeps the date relaxed, too; if you hit it off, you can suggest heading out for dinner, but if the sparks don’t exactly fly, you can just head home. Keep bottled water on hand for you and your dog, and perhaps some treats for your dogs. Before you grab that leash, though, check first to see if the dog park requires a special license or tag, or if you need to pay a fee in advance.