TWF1
Twinfilin-1 is a protein that in humans is encoded by the "TWF1" gene. This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. Model organisms. Model organisms have been used in the study of TWF1 function. A conditional knockout mouse line, called "Twf1" was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and  distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice, but no significant abnormalities were observed.