Cribriform plate
In mammalian anatomy, the cribriform plate, horizontal lamina or lamina cribrosa is part of the ethmoid bone. It is received into the ethmoidal notch of the frontal bone and roofs in the nasal cavities. It supports the olfactory bulb, and is perforated by olfactory foramina for the passage of the olfactory nerves to the roof of the nasal cavity to convey smell to the brain. The foramina at the medial part of the groove allow the passage of the nerves to the upper part of the nasal septum while the foramina at the lateral part transmit the nerves  to the superior nasal concha. A fractured cribriform plate can result in olfactory dysfunction, septal hematoma, cerebrospinal fluid rhinorrhoea (CSF rhinorrhoea), and possibly infection which can lead to meningitis. CSF rhinorrhoea (clear fluid leaking from the nose) is very serious and considered a medical emergency. Aging can cause the openings in the cribriform plate to close, pinching olfactory nerve fibers. A reduction in olfactory receptors, loss of blood flow, and thick nasal mucus can also cause an impaired sense of smell. Structure. The cribriform plate is part of the ethmoid bone, which has a low density, and is spongy. It  is narrow, with deep grooves supporting the olfactory bulb. Its anterior border, short and thick, articulates with the frontal bone. It has two small projecting alae (wings), which are received into corresponding depressions in the frontal bone to complete the foramen cecum. Its sides are smooth, and sometimes bulging due to the presence of a small air sinus in the interior. The crista galli projects upwards from the middle line of the cribriform plate. The long thin posterior border of the crista galli serves for the attachment of the falx cerebri. On either side of the crista galli, the cribriform  plate is narrow and deeply grooved. At the front part of the cribriform plate, on either side of the crista galli, is a small fissure that is occupied by a process of dura mater. Lateral to this fissure is a notch or foramen which transmits the nasociliary nerve; from this notch a groove extends backward to the anterior ethmoidal foramen. Keros classification. The Keros classification is a method of classifying the depth of the olfactory fossa. The depth of the olfactory fossa is determined by the height of the lateral lamella of the cribriform plate. Keros in 1962, classified the  depth into three categories. Function. The cribriform plate is perforated by olfactory foramina, which allow for the passage of the olfactory nerves to the roof of the nasal cavity. This conveys information from smell receptors to the brain. The foramina at the medial part of the groove allow the passage of the nerves to the upper part of the nasal septum while the foramina at the lateral part transmit the nerves to the superior nasal concha. Clinical significance. A fractured cribriform plate (anterior skull trauma) can result in leaking of cerebrospinal fluid into the nose and loss of sense of  smell. The tiny apertures of the plate transmitting the olfactory nerve become the route of ascent for a pathogen, "Naegleria fowleri". This amoeba tends to destroy the olfactory bulb and the adjacent inferior surface of the frontal lobe of the brain. This surface initially becomes the site of proliferation of the trophozoites of "Naegleria fowleri" and their subsequent spread to the rest of the brain and CSF. Because of its initial involvement and trophozoite presence in early phases of "Naegleria fowleri" infection, flushing of this region with saline using a device, to obtain "Naegleria fowleri" for diagnostic PCR and microscopic  viewing, has been proposed for patients affected by naegleriasis, by (Baig AM., et al.) in a recent publication. Researchers have suggested the same route to administer drugs at an early phase of infection by using a "Transcribrial Device" that has been proposed to kill this pathogen at the place of its maximum proliferation. In 2017 the inventor of this device suggested that after slight modifications this method could be effective in delivery of stem cells to the brain as well. A recent Australian study has shown that the bacterium causing the tropical disease melioidosis, "Burkholderia pseudomallei", can also invade the  brain via the olfactory nerve within 24 h by traversing the cribriform plate. Etymology. The cribriform plate is named after its resemblance to a sieve (from Latin "cribrum", "sieve" + -form). It is also known as the horizontal lamina, and the lamina cribrosa. Other animals. The cribriform plate is found in every mammal that has been studied. It serves the same function of allowing passage of the olfactory nerves.