Patons Rock (CRC Press, 2016). María Dolores Ugarte ‪María Dolores (Lola) Ugarte Martínez is a Spanish statistician specializing in spatial analysis, spatio-temporal analysis, epidemiology, and small area estimation. She is a professor in the Statististics, Computer Science, and Mathematics Department at the Public University of Navarre. Education and career. Ugarte earned a degree in mathematics from the University of Zaragoza in 1989, and completed her Ph.D. in 1996 at the Public University of Navarre. After post-doctoral research at Simon Fraser University, she became an associate professor at the Public University of Navarre in 1997, and full professor in 2009. She 	María Dolores Ugarte
10034169	Nouria Nouria Nouria is a female given name. Notable people with this given name include: Nouria Nouria is a female given name. Notable people with this given name include: 	Nouria
10034170	2000 Kroger St. Jude International – Singles 2000 Kroger St. Jude International – Singles Tommy Haas was the defending champion, but lost in the semifinals to Byron Black. Magnus Larsson won the title by defeating Byron Black 6–2, 1–6, 6–3 in the final. Seeds. All seeds received a bye to the second round. 2000 Kroger St. Jude International – Singles Tommy Haas was the defending champion, but lost in the semifinals to Byron Black. Magnus Larsson won the title by defeating Byron Black 6–2, 1–6, 6–3 in the final. Seeds. All seeds received a bye to the second round. 	2000 Kroger St. Jude International – Singles
10034171	C4orf36 C4orf36 C4orf36 (chromosome 4 open reading frame 36) is a protein that in humans is encoded by the c4orf36 gene. Gene. C4orf36 (also referred to as MGC26744, LOC132989, spostobu, fersnyby, and forsnyby) is located on chromosome 4 at band 4q21.3 on the minus strand. The gene is 21,052 base pairs long (chr4: 86,876,205-86,897,256) and contains 8 exons. Its gene neighborhood includes AFF1-AS1, RPL6P13, SLC10A6, LOC260422, and AFF1. No human paralogs for c4orf36 have been identified. Expression. RNA-seq and microarray data indicate that the c4orf36 gene is most highly expressed in the placenta, thyroid, ovary, and skin. It 	C4orf36
10034172	is also expressed in the lungs during fetal development, most highly at 17 weeks into development. Transcript. C4orf36 encodes 24 different mRNA transcripts, including 20 alternatively spliced variants and 4 unspliced forms. The transcript variant 1 (NM_144645.4), the subject of this article, is 908 nucleotides long and contains 5 exons. The promoter for transcript variant 1 (GXP_263623) spans the base pairs 86892213-86893422 on chromosome 4. Protein. C4orf36 encodes a 117 amino acid protein with a molecular weight of 13.28 kDa and an isoelectric point of 9.54. It contains a divalent cation tolerance protein CutA motif from amino acids 57	C4orf36
10034173	-88. No transmembrane domains or N-terminal signal peptides have been identified for c4orf36. The protein is predicted to undergo several post-translational modifications, including myristoylation and phosphorylation. Immunohistochemistry experiments have shown that the c4orf36 protein is localized to the cytosol and focal adhesion sites in the human U2-OS cell line, cultivated from the bone tissue of an osteosarcoma patient. Staining in human kidney tissue showed strong cytoplasmic and membranous expression within cells of tubules and moderate expression in glomeruli. Data from Human Protein Atlas also indicates that the protein is enriched in several regions of the brain, including 	C4orf36
10034174	the basal ganglia, cerebral cortex, pons, medulla, and in the hippocampus during its formation. Evolutionary history. C4orf36 orthologs are found in mammals and turtles. The gene is not found in other reptiles, birds, amphibians, fish, invertebrates, or outside of Kingdom Animalia. The gene likely first appeared around 318 million years ago, when mammals diverged from birds and reptiles. The following table presents a diverse subset of c4orf36 orthologs found using BLAST searches. Within mammals, the sequence identity of the selected orthologs ranges from 99.1% to 47%. Within turtles, the sequence identity ranges from 34.8% to 32.2%. C4orf36 is predicted to 	C4orf36
10034175	evolve more rapidly than other common human proteins, including cytochrome C and fibrinogen alpha. Clinical significance. Immunostaining of c4orf36 in syncytiotrophoblast cells (STBs) of mid-gestation human embryos showed a dense punctate pattern consistent with that of c4orf36’s fungal protein analog, dynein light chain, which is involved in intracellular cargo transport and other cellular processes. In another study, ovarian cancer (OVCA) cell lines were treated with gemcitabine. Higher c4orf36 expression was associated with in vitro chemoresistance to the drug, indicating that increased c4orf36 expression may be related to decreased OCVA patient survival. Furthermore, microarray data suggests that C4orf36 expression 	C4orf36
10034176	levels are higher in the saliva of pre-treatment pancreatic cancer patients than that of healthy controls. In one study on adaptogenic plants, neuroglia cell lines were treated with Rhaponticum carthamoides (RC), which promotes non-specific stress resistance and may mitigate the onset of senescence. C4orf36 was significantly deregulated in neuroglia cell lines after RC treatment, indicating that tighter c4orf36 regulation may play a role in the development of age-related disorders. A study on chondrogenesis found that c4orf36 has an oscillatory expression pattern coupled to that of ATP, indicating a potential link to skeletal development during embryogenesis. Mutations. Chemically 	C4orf36
10034177	significant amino acid changes in conserved regions of the c4orf36 protein were found with NCBI SNPGeneView. C4orf36 C4orf36 (chromosome 4 open reading frame 36) is a protein that in humans is encoded by the c4orf36 gene. Gene. C4orf36 (also referred to as MGC26744, LOC132989, spostobu, fersnyby, and forsnyby) is located on chromosome 4 at band 4q21.3 on the minus strand. The gene is 21,052 base pairs long (chr4: 86,876,205-86,897,256) and contains 8 exons. Its gene neighborhood includes AFF1-AS1, RPL6P13, SLC10A6, LOC260422, and AFF1. No human paralogs for c4orf36 have been identified. Expression. RNA-seq and microarray data indicate 	C4orf36
10034178	Carl Ohlson Carl Ohlson Carl R. Ohlson is an American politician. He won election to the Massachusetts House of Representatives from the 10th Plymouth district in 1968, 1970 and 1972, then lost to Karen Swanson in the 14th Plymouth district during the 1974 election cycle. Carl Ohlson Carl R. Ohlson is an American politician. He won election to the Massachusetts House of Representatives from the 10th Plymouth district in 1968, 1970 and 1972, then lost to Karen Swanson in the 14th Plymouth district during the 1974 election cycle. 	Carl Ohlson
10034179	Patons Rock Patons Rock Patons Rock is a coastal settlement in the Tasman District of New Zealand. It is located in Golden Bay, northwest of Tākaka. Located on the coast of Golden Bay, between Tākaka and Collingwood, north of State Highway 60, Patons Rock was named for the pioneer Paton family, who arrived in Nelson on the Fifeshire" in 1842. A shallow beach runs for and is regarded as being safe for swimming. The eponymous rock, Patons Rock, is located at the eastern end of the beach. Many of the dwellings in Patons Rock are holiday homes, and there are no shops  in the settlement. Patons Rock Patons Rock is a coastal settlement in the Tasman District of New Zealand. It is located in Golden Bay, northwest of Tākaka. Located on the coast of Golden Bay, between Tākaka and Collingwood, north of State Highway 60, Patons Rock was named for the pioneer Paton family, who arrived in Nelson on the "Fifeshire" in 1842. A shallow beach runs for and is regarded as being safe for swimming. The eponymous rock, Patons Rock, is located at the eastern end of the beach. Many of the dwellings in Patons Rock are holiday homes, and there