Kike Casanova gene. However, it can be suspected with a high IgE level and eosinophilia. Other suggestive laboratory findings include decreased numbers of B cells, T cells, and NK cells; and hypergammaglobulinemia. It can be distinguished from autosomal dominant hyper-IgE (STAT3 deficiency) because people with DOCK8 deficiency have low levels of IgM and an impaired secondary immune response. IgG and IgA levels are usually normal to high. It can be distinguished from the similar X-linked Wiskott–Aldrich syndrome by the presence of thrombocytopenia and the consequent bloody diarrhea, as well as its pattern of inheritance. WHIM syndrome, caused by a 	DOCK8 deficiency
25098729	mutation in CXCR4, is associated with similar chronic cutaneous viral infections. Treatment. Treatment in DOCK8 deficiency focuses on preventing and treating infections. Broad-spectrum antibiotics are a common mode of treatment when infection is present, though some infections (like lung abscesses) require surgical treatment. Pneumatocele may be treated with surgery, but the benefit is unclear. Surgical treatment is also recommended for skin abscesses, along with topical and systemic antibiotics and antifungals. Long-term treatment with systemic antibiotics, including trimethoprim/sulfamethoxazole, penicillins, and cephalosporins, is effective in preventing skin and lung infections. Other treatments used in DOCK8 deficiency include sodium cromoglycate	DOCK8 deficiency
25098730	, which improves white blood cell function, and isotretinoin, which improves skin condition. Sometimes, Intravenous immunoglobulin is used as a treatment, but its benefits have not been proven. Levamisole is also ineffective. Mixed clinical outcomes have been found with interferon gamma and omalizumab. Though early research on hematopoietic stem cell transplantation was equivocal, later research has shown it to improve immune function. Two patients have been cured by bone marrow transplantation. Cyclosporine A is a current topic of research; preliminary results have shown it to be effective. Prognosis. Children with DOCK8 deficiency do not tend to live long; sepsis is a 	DOCK8 deficiency
25098731	common cause of death at a young age. CNS and vascular complications are other common causes of death. Epidemiology. DOCK8 deficiency is very rare, estimated to be found in less than one person per million; there have been 32 patients diagnosed as of 2012. History. DOCK8 deficiency was first described in 2004. The mutation was discovered in 2009. DOCK8 deficiency DOCK8 deficiency, also called DOCK8 immunodeficiency syndrome, is the autosomal recessive form of hyperimmunoglobulin E syndrome, a genetic disorder characterized by elevated immunoglobulin E levels, eosinophilia, and recurrent infections with staphylococcus and viruses. It is caused by a mutation in 	DOCK8 deficiency
25098732	Kike Casanova Kike Casanova Enrique Kike" Casanova (born in Asunción, Paraguay, on 5 August 1980) is a Paraguayan television presenter, announcer and lawyer. Biography. Casanova spent ten years in the media. He is a man from the radio frequency that it was becoming an interesting product for the audiovisual industry and television. In 2003 decided to marry " Virginia Faccioli ", with whom he had a daughter, " Paula Casanova Faccioli ". He received his bachelor's degree in law in 2005, but from 1998 is linked to the TV being the co-host of "Hot 105" Radio Venus Cable Vision . He has participated in the  animation of events Fashion and Beauty: Miss Paraguay 2001 by Channel 9 SNT; pre selection of Miss Punta del Este on channel 8 of Punta del Este, with Michael Greco Uruguay; Parade and the World Peace in the Conrad of Punta del Este to the agency Dotto Models channel 21 that city. Career. In 1997 starts at Radio Venus leading the "Hot 105" program. Eventually continue driving several other programs within the radio. TV reaches the hands of Venus, which takes a program on TV, radio sponsored. It appears driving the TV show American Summer summer and participate in the  TV series College girls. Kike time, it moves through various frequencies as when looking for a music on the car radio. Santa Monica happen radio, Radio Luque 93.3, Radio City, Radio 100 and Radio Canal E40. Currently, he hosts a radio station "Monumental 1080 AM". In 2003, decides to cut this maelstrom of media work and decides to pause in order to complete their studies law. In 2005, it received as lawyer and specializes in the criminal part. A year later started with one of the programs of greatest hits of the Paraguayan television Dancing with the Stars (Paraguay) as  Co-driver accompanying the diva Menchi Barriocanal. A month later, Teleshow, head of the program late for most, it was only intended to cover the program Dancing but its success is still being issued today, considered one of the number one gossip programs from Paraguay. Kike has co-anchored the three successful issues of "Dancing with the Stars" in the Paraguayan version and turn Teleshow, was also as famous "Singing for a Dream 2" Paraguay led to " ". His workouts songs come from times of intercollegiate, song festivals and karaoke, that's why in 2008 leads another success as "Rush Karaoke  and Famous" Leaving the nonsense program Teleshow by Melissa Quiñonez. 14 October 2010 the dance competition premiered Dance with me Paraguay, where he led the program. In 2013 it leads for the fourth consecutive year BCPy. Kike Casanova Enrique "Kike" Casanova (born in Asunción, Paraguay, on 5 August 1980) is a Paraguayan television presenter, announcer and lawyer. Biography. Casanova spent ten years in the media. He is a man from the radio frequency that it was becoming an interesting product for the audiovisual industry and television. In 2003 decided to marry " Virginia Faccioli ", with whom he had a daughter, " Paula