Reticuline
Reticuline is a chemical compound found in a variety of plants including "Lindera aggregata", "Annona squamosa", and "Ocotea fasciculata" (also known as "Ocotea duckei"). It is based on the benzylisoquinoline structure. Reticuline is one of the alkaloids found in opium, and experiments in rodents suggest it possesses potent central nervous system depressing effects. It is the precursor of morphine and many other alkaloids. It is also toxic to dopaminergic neurons causing a form of atypical parkinsonism known as Guadeloupean Parkinsonism. Metabolism. 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase uses "S"-adenosyl methionine and 3'-hydroxy-"N"-methyl-("S")-coclaurine to produce "S"-adenosylhomocysteine and ("S")-reticuline. Reticuline oxidase uses  ("S")-reticuline and O to produce ("S")-scoulerine and HO. Salutaridine synthase uses ("R")-reticuline, NADPH, H, and O to produce salutaridine, NADP, and HO. Salutaridine can then be transformed progressively to thebaine, oripavine, and morphine. 1,2-dehydroreticulinium reductase (NADPH) uses ("R")-reticuline and NADP to produce 1,2-dehydroreticulinium, NADPH, and H.