2021 Boucles de la Mayenne
The 2021 Boucles de la Mayenne () was the 46th edition of the Boucles de la Mayenne road cycling stage race, which took place between 27 and 30 May 2021 in the Mayenne department in northwestern France. The race had been promoted from category-2.1 race to a category-2.Pro race after the 2019 season and was due to be a part of the inaugural edition of the UCI ProSeries, but after the 2020 edition was cancelled due to the COVID-19 pandemic, it made its UCI ProSeries debut in 2021, while also still being a part of the  2021 UCI Europe Tour. Teams. Five of the nineteen UCI WorldTeams, fourteen UCI ProTeams, and two UCI Continental teams made up the twenty-one teams that participated in the race. and , with five riders each, were the only teams not to enter a full squad of six riders. However, two late scratches, one each from and , left 122 riders on the start line. 111 riders finished the race. UCI WorldTeams UCI ProTeams UCI Continental Teams