Eggerthellaceae
The Eggerthellaceae are a family of Gram-positive, rod- or coccus-shaped Actinomycetota. It is the sole family within the order "Eggerthellales." The name "Eggerthellaceae" is derived from the Latin term "Eggerthella," referring to the type genus of the family and the suffix "-ceae," an ending used to denote a family. Together, "Eggerthellaceae" refers to a family whose nomenclatural type is the genus "Eggerthella". Biochemical characteristics and molecular signatures. Members of this family are mostly anaerobic, non-motile (with the exception of some "Gordonibacter" and "Senegalimassilia" species that exhibit motility), asaccharolytic and do not form spores. "Eggerthellaceae" species are  commonly isolated from human and animal faeces and other human sources such as the colon, vagina, oral cavity and blood. Some species have also been isolated from human samples of periodontal or endodontic infections, Crohn's disease and severe blood bacteremia. The G+C content for "Eggerthellaceae" species is between 43.4 and 66.3 mol%. Analysis of genome sequences identified 13 conserved signature indels (CSIs) in diverse proteins that are exclusively present in different "Eggerthellaceae" species. The proteins containing these CSIs are: contaexcinuclease ABC subunit UvrC, DNA polymerase III subunit alpha, ribonuclease III, tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase (MiaB), peptide chain release factor  2, 16S rRNA (cytosine(1402)-N(4))-methyltransferase, elongation factor Tu, UDP-N-acetylglucosamine 1-carboxyvinyltransferase DNA polymerase III subunit epsilon, UDP-glucose 4-epimerase and DNA-directed RNA polymerase subunit alpha. The identified CSIs provide reliable and important means to distinguish members of "Eggerthellaceae" from all other Coriobacteriia as well as other bacteria. Phylogeny. The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN). The phylogeny is based on whole-genome analysis. See figure for a detailed phylogenetic tree.