Lori L. Isom
Lori L. Isom is an American pharmacologist, an elected Fellow of the American Association for the Advancement of Science, and a member of the National Academy of Medicine. Biography. Isom was raised in Oshkosh, Wisconsin. She received her BA from Washington University in St. Louis in 1982 and her PhD in Pharmacology from Vanderbilt University in 1987. She completed her postdoctoral fellowship in 1993 at the University of Washington in the Catterall lab. Currently, she serves as the chair of the Department of Pharmacology at the University of Michigan, as well as a Professor of Molecular and  Integrative Physiology and Professor of Neurology. Research. Her research has focused on the physiology and pharmacology of voltage-gated sodium channels and the role of sodium channel mutations in epilepsy, cardiac arrhythmia, and demyelinating disease. She has played a critical role in using translational research to model and find treatment for a rare form of infantile epilepsy known as Dravet syndrome (DS) that increases risk for Sudden Unexpected Death in Epilepsy (SUDEP). The syndrome has been linked to loss of function mutations in the SCN1A gene that causes an improper folding of Na1.1 channels in GABAergic interneurons. Decreased excitation of  GABA interneurons can lead to neuronal hyper-excitability and seizures as well as cardiac arrhythmias. Dr. Isom’s lab has published over 90 articles and received $22 million in funding to investigate genetic links between neuronal excitability and epileptic encephalopathy.