Uhambo lomsebenzi luzingxenye ye-2 no-Antony Raj Jayamani. Uye wakwazi ukugxila ekusesheni imisebenzi futhi wakwazi ukuthola umsebenzi ensimini efanayo. Statins or 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors are drug of choice for lowering cholesterol. This class of drug have also pleiotropic effects such as regulation of endothelial function, NO synthesis, the reduction of oxidative stress and inflammation. In regard to kidney, previous data showed impaired mesangial and vascular smooth muscle cell proliferation, mesangial matrix expansion and macrophage infiltration by use of statins . Therefore, statins could provide additional benefit in preventing the fibrosis, interstitial inflammation and oxidative stress in setting of chronic CsA nephrotoxicity. There is limited data in literature at this point. Li et al., observed decreased inflammation and fibrosis by use of pravastatin added to cyclosporine in an experimental study . Zhou Seng et al. have shown suppressed oxidative stress in renal tissue of rats by using statin . In the present study, we have shown improved kidney functions and histopathological findings in atorvastatin group. Antioxidant effect is of great importance in the prevention of nephrotoxicity. Statin therapy has a further positive impact rising levels of NO in the renal tissue. Antioxidant effect is also proposed to be contributed to the NO bioavailability [2,43]. We have shown higher NO value in atorvastatin group however, there was no statistical significance, perhaps due to the short duration of treatment.