Lewis Moody regulatory review was carried out. The clinical protocol began on May 22, 1989, and included 10 patients. The procedure was shown to be safe. Rosenberg went on to develop gene therapy/immunotherapy clinical protocols for cancer. Anderson and Blaese carried out the first gene therapy protocol, on a 4-year-old girl, named Ashanthi DeSilva, who was critically ill with adenosine deaminase deficiency severe combined immunodeficiency disease (ADA SCID). Preliminary studies included development of a retroviral vector containing the ADA gene together with additional safety features, creation of ADA deficient human T cell lines used for testing ADA vectors, and 	William French Anderson
9189964	creation of a biotechnology company, Genetic Therapy Inc., to manufacture the ADA vector, called LASN, under strict GMP FDA requirements. Anderson also created, and became editor-in-chief of, a new journal, Human Gene Therapy, in 1990. This new journal published not only original scientific research papers but also articles on ethical and regulatory issues relating to gene therapy. Ashanthi received her first infusion of cells on September 14, 1990, with no complications. She received 10 more infusions over the next 2 years. Her immune evaluation studies became normal and she became healthy with no major infections. A thorough immune 	William French Anderson
9189965	status follow-up was done after 12 years: she remained healthy with 20% of her lymphocytes still carrying an active retroviral ADA gene – a sufficient percentage to ensure immunologic protection. She is now 33 years old, married, and works as a journalist and writer. Late career research projects. In 1992, Anderson followed his wife to Los Angeles, where she accepted the position of chief of surgery at Los Angeles Children's Hospital. He became professor of biochemistry and pediatrics at the University of Southern California (USC). Anderson maintained his intense interest in gene therapy and was able to develop a 	William French Anderson
9189966	retroviral gene therapy vector that could target the collagen matrix surrounding cancer nodules. He wrote a number of reviews of gene therapy in both the scientific literature and in the popular literature. Anticipating the value of lab-on-a-chip technology for the molecular analysis of individual cells, Anderson joined forces with Stephen Quake, professor of applied physics at California Institute of Technology. Quake was developing lab-on-a-chip technology using soft polymers. Anderson became a visiting associate in applied physics at Caltech from 2001 to 2006, while maintaining his USC positions, and succeeded in developing an improved microfluidic 	William French Anderson
9189967	valve that was patented and has become the core of soft polymer lab-on-a-chip devices. His final project before he was arrested was the discovery and identification of a factor in the serum of irradiated animals that could rescue lethally irradiated animals even 24 hours after the irradiation. Purification from the serum demonstrated that the factor was Interleukin 12. During the 12 years that Anderson has been in prison, IL-12 has been shown to potentially be a very important adjuvant drug in cancer treatment. Other activities. Other activities that have played a major role in Anderson's life 	William French Anderson
9189968	are sports, sports medicine, and forensic medicine. Sports. Track – Anderson has been a competitive runner his entire life primarily at the 400-meter distance. He still competes in age-oriented local and regional track meets. Martial Arts – Anderson is a 5th-degree black belt in Taekwondo and was certified a Master in 1988 by the Kukkiwon in Seoul Korea. In the mid-1990s, he missed competing and, since Taekwondo did not have a senior division, he acquired a black belt in karate. He then competed in the AAU national karate competition, and, in 1998, was national champion in sparring in the 	William French Anderson
9189969	oldest age division. He also taught martial arts for 20 years. Sports medicine. Anderson has been a ring doctor and tournament doctor in a large number of competitions. In 1981, he became the Team Physician for the National Taekwondo Team, and was also the team physician at the 1988 Olympics in Seoul Korea when Taekwondo became an Olympic sport. He has written several sports medicine articles on prevention and treatment of taekwondo injuries. In addition, he was chairman of the medical committee of the World Taekwondo Federation from 1985 to 1988. Forensic medicine. Anderson is best known in forensic medicine 	William French Anderson
9189970	for his forensic analysis of the famous April 11, 1986, FBI firefight which, at the time, was the deadliest firefight in the history of the FBI. His analysis, privately printed in 1996, was accepted by the FBI as the official version, and every new FBI agent was given a copy of his report. After 10 years, the FBI allowed Anderson to make the report public, and it was published with a new foreword by Paladin Press in 2006. Anderson also published a forensic analysis of the Warren Earp killing, as well as a study of the bruises beneath soft body 	William French Anderson
9189971	armor when bullets of various calibers strike a person wearing the armor. Sexual abuse conviction. Anderson was arrested on July 30, 2004, on allegations of sexual abuse of a minor girl. He was convicted and jailed on July 19, 2006, of three counts of lewd acts upon a child under the age of 14, and one count of continuous sexual abuse. On February 2, 2007, he was sentenced to 14 years in prison and ordered to pay $68,000 in restitution, fines, and fees. The victim was the daughter of his senior lab scientist and business partner. The jury was 	William French Anderson
9189972	played a sting meeting recording between Anderson and the victim in which Anderson is heard to say a number of damaging statements. He lost all his appeals through the court system, and served his entire sentence, which was shortened based on good behavior. He was released from prison on May 17, 2018, and is currently serving a 5-year parole. Published books. Development of Iron Chelators for Clinical Use. Anderson, W.F. and Hiller, H.C., eds., DHEW Publ. No. (NIH) 76-994, 1976. Fourth Cooley's Anemia Symposium. Anderson, W.F.; Bank, A.; Zaino, E.C., eds., Ann. NY Acad. Sci., Vol. 344	William French Anderson
9189973	, 1980. Development of Iron Chelators for Clinical Use: Proceedings of the Second Symposium. Martell, A.E.; Anderson, W.F.; Badman, D., eds., Elsevier-North Holland, New York, 1981. Fifth Cooley's Anemia Symposium. Bank, A.; Anderson, W.F.; Zaino, E.C., eds., Ann. NY Acad. Sci., Vol. 445, 1985. Forensic Analysis of the April 11, 1986, FBI Firefight. Anderson, W.F., Paladin Press, 2006. William French Anderson William French Anderson (born December 31, 1936) is an American physician, geneticist and molecular biologist. He is known as the Father of Gene Therapy. He graduated from Harvard College in 1958, Trinity College, Cambridge University (England) in 1960	William French Anderson
9189974	Lewis Moody Lewis Moody Lewis Walton Moody MBE (born 12 June 1978 in Ascot) is a retired English rugby union player who played for Leicester Tigers and Bath Rugby and was part of the 2003 World Cup winning side. Moody is known for the enthusiasm with which he plays the game, his willingness to chase down opponents and his ability to compete for possession at restarts, earning him the nickname Mad Dog" from teammates and supporters. Background. When he was five he took up mini rugby at Bracknell, when a school friend suggested he join him. He played at Bracknell until 12  years old. He was educated at Eagle House Prep School, then Oakham School in Rutland, where he initially played rugby union at centre before moving to full back. He later studied Business Administration at De Montfort University while playing for Leicester Tigers. Club career. He first met Ed Houston then his life began. In the Leicester Tigers youth team, he played flanker. He became the youngest Leicester Tigers' player to play a league game at 18 years and 94 days, a record now surpassed by Ben Youngs. He soon became established as Neil Back's understudy for the openside flanker  shirt. Making the Tigers starting XV was difficult however, as internationals Neil Back and Martin Corry took two of the three starting positions, with Paul Gustard and Will Johnson (younger brother of Martin) fighting for the remaining place. Moody was an unused replacement for the 2001 Heineken Cup Final but started the victorious 2002 Heineken Cup Final, and was a member of the Tigers side in the four Premiership winning seasons in 1999, 2000, 2001 and 2002. The arrival of New Zealand international openside Josh Kronfeld at Leicester in 2001, threatened to relegate Moody to third choice openside. However, Kronfeld  failed to settle at the club and despite offers from Harlequins and Bath, Moody decided to stay. After the World Cup success in 2003, he suffered a stress fracture of his foot which took a long time to heal and kept him out of the remaining 2003–04 season. Moody made a return in October 2004, in the Heineken European Cup match against Calvisano. Moody won his fifth Premiership medal in 2007, starting the final and scoring a try as Leicester defeated Gloucester. He was injured for much of the 2008–2009 season, which was his Testimonial season for the club, but  returned to play in the 73–3 win over Bristol, and featured in both the Heineken Cup final and the Guinness Premiership win. Moody stayed fit for the entire 2009–2010 season, and even captained the side in the home fixture against Sale. The Tigers won the 2009–10 Guinness Premiership, beating Saracens 33–27 at Twickenham. In the 2010–2011 season, he joined Bath Rugby on a three-year deal along with Sam Vesty. Moody picked up a knee ligament injury in Bath's 55-16 win over Aironi in January 2011 but had been confident of making the England team for their opening  Six Nations clash with Wales on 4 February. Moody announced his retirement from rugby on 6 March 2012 with immediate effect due to injuries. International career. Moody scored two tries for England Colts against Wales in April 1997, and was a member of the side that won the Madrid Sevens at the end of that season. He was later called up to the senior team for the 1998–99 "tour from hell" but did not make an appearance. Moody made his England debut against Canada on 2 June 2001, when the established internationals Neil Back and Richard Hill were touring Australia  with the British and Irish Lions. He won a further two caps on the North American tour and scored a try against the US Eagles in San Francisco. He was then called up to the senior squad for the match against Ireland in Dublin in October 2001 and came on to win cap number four. Continued impressive form saw him challenge his teammate, Neil Back, for the coveted England No.7 shirt, starting in two Six Nations games the following season. Moody displaced Lawrence Dallaglio from the first choice England XV for the 2002/3 autumn internationals scoring a try in the  game against New Zealand, but was injured against South Africa and Dallaglio regained his place. He returned to fitness and again featured in Clive Woodward's plans, but a further injury in the first Six Nations match against France threatened to curtail the rest of his season. He was not considered for the summer tour due to that injury, but recovered well enough to play in the pre-world cup friendlies against France and Wales in the summer, scoring a try in the game at the Millennium Stadium. He played a part in all seven World Cup matches and came  on as a replacement in the final to replace Hill. He won the final line-out in the phase of play which led to Jonny Wilkinson's winning drop goal. He missed the remaining 2003–4 season due to a foot injury. With the retirement of Dallaglio and Back, and Hill out injured, he started all three of England's autumn internationals. Moody remained an England mainstay into 2005. That year he became the first English player to be sent off at Twickenham, when he was dismissed for fighting during the autumn international with Leicester teammate Alex Tuilagi. Having missed the  2007 Six Nations Championship through injury, Moody was selected as part of the England squad for the 2007 World Cup in France. Having been named to start a warm up match against France Moody suffered a further injury and consequently was left out of the starting line up for England's first three games of the campaign. Following a disappointing start to the tournament Moody was called into the starting line up for the final pool match against Tonga, where he was lauded for England's much improved competition at the breakdown. Moody kept his place in the starting line  up for the quarter final against Australia where he 'outshone his illustrious opposite number' George Smith. Moody again started the semi final against France, and lined up against South Africa in the World Cup final on 20 October, which England narrowly lost to the southern hemisphere side. He was picked for the 2008 Six Nations Championship and started in the first game against Wales but was substituted in the first half because of an Achilles tendon injury. He returned to play against the Barbarians in June 2009, but was subsequently dropped from the squad, and appeared in the England Saxons  EPS for the 2009–10 Season. Club form and injuries to other opensides such as Tom Rees saw him regain his England starting position for the Autumn Internationals against Australia, Argentina, and New Zealand. He continued this form into the 2010 Six Nations Championship. Moody captained England in their final 2010 Six Nations Championship match against France in Paris, replacing regular captain Steve Borthwick, who had to pull out due to injury. He was also named England Captain for the 2010 summer tour to Australia. Due to the knee injury he picked up in January 2011, Lewis missed the whole of  the 2011 Six Nations tournament however Martin Johnson confirmed Lewis would be England captain for the 2011 Rugby World Cup in New Zealand, provided he was fit. He was selected in the 30-man squad that flew to New Zealand. On 23 October 2011, Lewis Moody announced his retirement from international rugby. The Lewis Moody Foundation. The Lewis Moody Foundation, inspired by young rugby fan Joss Rowley Stark, raises funds to promote awareness of brain tumours in children through the award-winning HeadSmart campaign, funds vital research into brain tumour diagnosis and gives families living with critical illness days out  of the ordinary to lift spirits and create special memories. Personal life. Moody married Annie (an interior designer) in June 2006. The couple live in Bradford On Avon in Wiltshire and have a property development company. They have two children. He enjoys extreme sports—although he suffers from vertigo—and his current hobbies include wakeboarding, travelling and golf. Moody is a patron and supporter of a number of charities including The Social Entrepreneurs Project, HOPEHIV, Rainbow Trust children's charity and Our Lady's Children's Hospital. In August 2012 Moody highlighted his battle with ulcerative colitis and the impact  this had on his training. In May 2014, Lewis and his wife Annie set up The Lewis Moody Foundation, inspired by Joss Rowley-Stark, to fund ground breaking research to improve the diagnosis and treatment of brain tumours and gives families a day out of the ordinary to lift spirits and create special memories. In August 2014, Moody was one of 200 public figures who were signatories to a letter to "The Guardian" opposing Scottish independence in the run-up to September's referendum on that issue. Lewis Moody Lewis Walton Moody MBE (born 12 June 1978 in Ascot) is