HDAC6
Histone deacetylase 6 is an enzyme that in humans is encoded by the "HDAC6" gene. Function. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromatin structure and affects transcription. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains that appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. It retracts the cilium of the cell, which is necessary prior to mitosis. HDAC encourages cell motility  and catalyzes α-tubulin deacetylation. As a result the enzyme encourages cancer cell metastasis. HDAC6 affects transcription and translation by regulating heat-shock protein 90 (Hsp90). HDAC6 is required in the formation of stress granule (SG) proteins and is instrumental in SG formation; pharmacological inhibition or genetic removal of HDAC6 abolished SG formation.. HDAC6 bonds with high affinity to ubiquitinated proteins. HDAC6 is involved in leptin sensitivity. Clinical relevance. Mutations in this gene have been associated to Alzheimer's disease.<ref name="doi.10.1093/hmg/dds125"></ref> Over expression of this protein correlates with tumorigenesis and cell survival. HDAC6 also encourages metastasis of  cancer cells. Interactions. HDAC6 has been shown to interact with HDAC11 and Zinc finger and BTB domain-containing protein 16. HDAC6 interacts with SG (Stress granule) protein G3BP1.