Granulomatous amoebic encephalitis
Granulomatous amoebic encephalitis (GAE) is a rare, usually fatal, subacute-to-chronic central nervous system disease caused by certain species of free-living amoebae of the genera "Acanthamoeba", "Balamuthia" and "Sappinia pedata". The term is most commonly used with "Acanthamoeba". In more modern references, the term "balamuthia amoebic encephalitis" (BAE) is commonly used when "Balamuthia mandrillaris" is the cause. Symptoms and signs. GAE starts slowly, with symptoms like headache, nausea, dizziness, irritability and a low-grade fever. The CNS symptoms depend on the part of the brain that is infected. Changes in behavior are an important sign . Other CNS signs may include seizures, focal neurologic signs, diplopia (double vision), cranial nerve palsies, ataxia, confusion, and personality changes. Some of the symptoms may mimic glioma (especially brainstem glioma), or other brain diseases, which may hamper timely diagnosis. The symptoms are caused by inflammatory necrosis of brain tissue brought on by compounds released from the organisms. Diagnosis. The condition can be difficult for doctors to diagnose, because it is a rare disease. A brain biopsy will reveal the presence of infection by pathogenic amoebas. In GAE, these present as general inflammation and sparse granules. On microscopic examination, infiltrates of  amoebic cysts and/or trophozoites will be visible. Treatment. Section::::"Acanthamoeba". Antifungal drugs including ketoconazole, miconazole, 5-flucytosine and pentamidine have been shown to be effective against "Acanthamoeba" "in vitro". Section::::"Balamuthia". Like with "Acanthamoeba", infection of the brain with this organism rapidly turns fatal in most cases. However some survivors have been reported: Two patients survived after being successfully treated with a therapy consisting of flucytosine, pentamidine, fluconazole, sulfadiazine, and azithromycin. Thioridazine or trifluoperazine was also given. Successful treatment in these cases was credited to "awareness of "Balamuthia" as the causative agent of encephalitis and early initiation of antimicrobial therapy." In one  case, cloxacillin, ceftriaxone, and amphotericin B were tried, but this treatment protocol did not prove effective. Prognosis. Even with treatment, CNS infection with "Acanthamoeba" is often fatal, and there are very few recorded survivors, almost all of whom suffered permanent neurocognitive deficits. The prognosis is largely influenced by the time of diagnosis, how virulent and sensitive the "Acanthamoeba" strain is, and, most crucially, the immune status of the affected person. Due to it commonly being an opportunistic infection, the prognosis is generally poor, with a mortality rate approaching 90%. "Sappinia pedata" can cause GAE, however only one case of GAE  due to "S. pedata" infection has ever been reported, and the patient survived without any long-term consequences.