Revealed mechanism for inhibiting bacterial invasion of colonic epithelia: Clue to the development of drugs for ulcerative colitis -- ScienceDaily
A group of researchers has elucidated how a gene named Ly6/Plaur domain containing 8 (Lypd8) inhibits bacterial invasion of colonic epithelia, regulating intestinal inflammation. This achievement may lead to the development of drugs for ulcerative colitis.
Ly6/PLAUR domain containing 8 (Lypd8), which is a highly glycosylated GPI-anchored protein, is highly and selectively expressed in epithelial cells on the uppermost layer of the intestinal gland and shed into the intestinal lumen. Lypd8 inhibits intestinal bacterial invasion of the colonic mucosa by binding to the intestinal bacteria, and thereby regulates the intestinal inflammation.
Ryu Okumura, Takashi Kurakawa, Takashi Nakano, Hisako Kayama, Makoto Kinoshita, Daisuke Motooka, Kazuyoshi Gotoh, Taishi Kimura, Naganori Kamiyama, Takashi Kusu, Yoshiyasu Ueda, Hong Wu, Hideki Iijima, Soumik Barman, Hideki Osawa, Hiroshi Matsuno, Junichi Nishimura, Yusuke Ohba, Shota Nakamura, Tetsuya Iida, Masahiro Yamamoto, Eiji Umemoto, Koichi Sano, Kiyoshi Takeda. Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature, 2016; 532 (7597): 117 DOI: 10.1038/nature17406
Osaka University. "Revealed mechanism for inhibiting bacterial invasion of colonic epithelia: Clue to the development of drugs for ulcerative colitis." ScienceDaily. ScienceDaily, 25 May 2016. <www.sciencedaily.com/releases/2016/05/160525101727.htm>.
Osaka University. (2016, May 25). Revealed mechanism for inhibiting bacterial invasion of colonic epithelia: Clue to the development of drugs for ulcerative colitis. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2016/05/160525101727.htm
Osaka University. "Revealed mechanism for inhibiting bacterial invasion of colonic epithelia: Clue to the development of drugs for ulcerative colitis." ScienceDaily. www.sciencedaily.com/releases/2016/05/160525101727.htm (accessed May 26, 2017).
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