Lithium tetramethylpiperidide
Lithium tetramethylpiperidide (often abbreviated LiTMP or LTMP) is a chemical compound with the molecular formula . It is used as a non-nucleophilic base, being comparable to LiHMDS in terms of steric hindrance. Synthesis. It is synthesised by the deprotonation of 2,2,6,6-tetramethylpiperidine with "n"-butyllithium at −78 °C. Recent reports show that this reaction can also be performed 0 °C. The compound is stable in a THF/ethylbenzene solvent mixture and is commercially available as such. Structure. Like many lithium reagents it has a tendency to aggregate, forming a tetramer in the solid state. Lithium tetramethylpiperidide Lithium