Setiptiline
Setiptiline (brand name Tecipul), also known as teciptiline, is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It was launched in 1989 for the treatment of depression in Japan by Mochida. Pharmacology. Pharmacodynamics. Setiptiline acts as a norepinephrine reuptake inhibitor, α-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT subtypes, as well as an H receptor inverse agonist/antihistamine. Chemistry. Setiptiline has a tetracyclic structure and is a close analogue of mianserin and mirtazapine, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-azamianserin.