Petrobrasaurus a patient's own (autologous) collected hematopoietic stem cells of any malignant cells it may still contain at the time of harvesting. In 1989 Nova Pharmaceutical took over development of the compound and in 1992, it submitted a new drug application to the FDA for using perfosamide to purge malignant cells in transplants for the treatment of acute myeloid leukemia. In the ensuing year, it merged with Scios to become Scios Nova. In March 1993, the FDA's Oncology Drugs Advisory Committee rejected the application because all the data was from the experimental uses, and no randomized clinical trial had 	Perfosfamide
14980499	been conducted. At the review meeting, Scios Nova also announced that it would not fund further development of the drug candidate. Chemistry. Perfosfamide is an oxazaphosphorine compound, similar to mafosfamide and cyclophosphamide. Like those compounds it, is metabolized to 4-hydroxycyclophosphamide, which eventually gives rise to the two directly cytotoxic metabolites — phosphoramide mustard and acrolein. Perfosfamide Perfosfamide, or 4-hydroperoxycyclophosphamide (trade name Pergamid) was an experimental drug candidate for blood cancers that was rejected by the FDA in 1993 and never reached the market. Intended use. Perfosfamide was used experimentally by oncologists in the 1980s for use in bone marrow 	Perfosfamide
14980500	Petrobrasaurus Petrobrasaurus Petrobrasaurus is a genus of herbivorous sauropod dinosaur. It is a titanosaur which lived during the upper Cretaceous period (Coniacian-Santonian age) in what is now Rincón de los Sauces, Patagonia, Argentina. It is known from the holotype MAU-Pv-PH-449 — a partial disarticulated skeleton recovered from the Plottier Formation (Neuquén Basin), Argentina. This genus was named by Leonardo S. Filippi, José Ignacio Canudo, Leonardo J. Salgado, Alberto C. Garrido, Rodolfo A. Garcia, Ignacio A. Cerda and Alejandro Otero in 2011, and the type species is Petrobrasaurus puestohernandezi. The generic name is derived from Petrobras" (oil company) and "saurus , lizard". The specific name refers to the Puesto Hernández oil field, where the fossil remains were found. Petrobrasaurus Petrobrasaurus is a genus of herbivorous sauropod dinosaur. It is a titanosaur which lived during the upper Cretaceous period (Coniacian-Santonian age) in what is now Rincón de los Sauces, Patagonia, Argentina. It is known from the holotype MAU-Pv-PH-449 — a partial disarticulated skeleton recovered from the Plottier Formation (Neuquén Basin), Argentina. This genus was named by Leonardo S. Filippi, José Ignacio Canudo, Leonardo J. Salgado, Alberto C. Garrido, Rodolfo A. Garcia, Ignacio A. Cerda and Alejandro Otero in 2011, and