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/Blog/IDFP/I-IDFP (615250-02-7): Imiphumo, Isisombululo, Iingxelo
ezaposwa ngomhla 07 / 15 / 2018 by UDkt Patrick Young bha liweyo IDFP. Ibe 1 Comment.
Yonke into ngeMibolerone (Hlola amaconsi)
1.Yintoni i-IDFP (615250-02-7)
2.I-IDFP (615250-02-7) isebenza njani?
3.IDFP (615250-02-7) iziphumo
5. I-IDFP (615250-02-7) isilumkiso
I-6.IDFP (615250-02-7) iimpendulo
I.IDFP Abalinganiswa basisiseko:
I-molecular Formula: C15H32FO2P
Isisindo somzimba: 294.391
Isitoreji sokugcina: -20 ° C
1. Yintoni i-IDFP (615250-02-7)
IDFP(615250-02-7), liyinxalenye ye-organophosphorus ehambelana ne-agent agent sarin. Igama leKhemikhali liquka: IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; I-P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID; i-1- [fluan (propan-2-yloxy) iphosphoryl] iododecane.
I-IDFP (i-615250-02-7) Ukuchazwa kweMichiza
igama IDPF, ISOPROPYL DODECYLFLUOROPHOSPHONATE
I-Molecular Formula C15H32FO2P
Isisindo somzimba 294.391
ukugcinwa Temp -20 ° C
Ukhetho I-IDFP yinxalenye ye-organophosphorus enxulumene ne-agent agent sarin. Njenga-sarin, i-IDFP yinto yokungenakunyuswa engabonakaliyo kwi-enzyme eyahlukileyo ekhonza ukudiliza ama-neurotransmitters
2. I-IDFP (615250-02-7) isebenza njani?
I-endocannabinoids, i-2-arachidonoyl glycerol (i-2-AG) kunye ne-arachidonoyl ethanolamide (AEA), i-lipids esebenzayo yezinto eziphilayo ezilawula imisebenzi ehlukeneyo ye-neurological and metabolic ngokusebenzisa i-cannabinoid receptors, i-cannabinoid ephakathi (CB1) ne-peripheral cannabinoid (CB2). I-Monoacylglycerol lipase (MAGL) kunye ne-acety acid acide hydrolase (FAAH) i-hydrolyze i-2-AG kunye ne-AEA, ngokulandelanayo, ngaloo ndlela iphelisa umsebenzi wabo wezinto eziphilayo. IDFP (615250-02-7) yikhompawundi ze-ukuba abahlaselwe MAGL ezilawulayo kunye FAAH kunye IC50 amaxabiso 0.8 kunye 3 NM, respectively.1 At 10 mg / kg, IDFP liziphakamisa amanqanaba ingqondo 2-AG kunye AEA ngaphezu 10- i-fold, kwaye iyanciphisa amanqanaba e-arachidonic acid ngokukhululeka okufanayo.
3. IDFP (615250-02-7) iziphumo
Imiphumo yokuziphatha ye-cannabinoid ekuxhomekeke kwi-CBNUMX
Zintoni ii IDFP (615250-02-7)ziphumo? Ngaphakathi kwe-5 min emva kokunonyango nge-IDFP (i-10 mg kg-1, ip), iigundane zithatha i-posture kwaye zihlala zingapheliyo zivule amehlo. Eli gama lokungahambi kakuhle lalikhumbuza iimpendulo zokuziphatha ezifunyenwe yi-CB1 i-agonists ngokuthe ngqo, eyasishukumisela ukuba sihlolisise izilwanyana eziphathwe yi-IDFP kwiimvavanyo ze-tetrad zokuziphatha kwe-cannabinoid. I-IDFP yafunyanwa ukuvelisa zonke iziphumo ezine zokuziphatha ezilindelwe ekukhuthazeni i-CB1-hypomotility, analgesia, catalepsy kunye ne-hypothermia. Ezi mpawu zendlela yokuziphatha zivaliwe ukuxhaswa kwangaphambili kunye ne-CB1 ye-receptor antagonist AM25120 kwaye babengekho kwi-CB1 (- / -) i-mice21. Ezi ziphumo zicebise ukuba ukukhutshwa kwe-endocannabinoid metabolism bekuxanduva lokuthatha isenzo se-IDFP. Ubukhulu beempembelelo eziphawulwe nge-IDFP befana neyo-CB1 agonist ngqo, i-WIN55212-2 (10 mg kg-1, ip). Ukusebenzisa amalungiselelo okubumbana kwengqondo efana ne-mouse, i-IDFP idlulisela i-CB1 agonist ebopha kwi-vitro nge-IC50 ye-2 nM17, efana ne-IC50 yayo ye-MAGL (0.8 nM) ne-FAAH (3 nM), ngelixa i-30 nM ayizange ibenze kakhulu (5 ± 9%, n = 6, p> 0.05) khuthaza i-guanosine triphosphate ebophayo. Oku kubonisa ukuba iimpembelelo ze-IDFP ayisebenzisi njenge-agonist ye-receptor ngqo kwiindawo ezifanelekileyo.
Ukuphazamiseka kwe-endocannabinoid metabolism kwi vivo
Imisebenzi ye-Endocannabinoid-hydrolyzing yahlolwa kwiingcambu zeengqondo ezivela kwi-IDFP- (10 mg kg-1, ip) kunye neegundane eziphathwe ngezithuthi. Eli nqanaba lonyango le-IDFP lonyulwe kwiinkalo zempendulo zemizamo yokuvelisa ukuziphatha okufana ne-cannabinoid. I-h emva kwonyango, i-hydrolysis ye-2-AG kunye ne-anandamide yayinqatshelwe ngu-86 ± 1% kunye ne-94 ± 1%, ngokulandelanayo, kwiisishu zeengqondo ezivela kwizilwanyana eziphathwe yi-IDFP. Ngokwahlukileyo, akukho ukukhutshwa kwe-AChE eyabonakalayo yabonwa kunye ne-IDFP kwilingo elifanayo, oluhambelanayo nokungabikho kwesifo sotywala. I-IDFP i-analog ende ende ye-sarin kunye ne-dodecyl ithatha indawo ye-methyl, utshintsho olubangelwa kwi-AChE ephazamisayo.
Amanqanaba amancinci omsebenzi we-endocannabinoid hydrolytic ebonwe kwiingxube zengqondo zezilwanyana eziphathwe yi-IDFP ezihambelana nokunyuka kwama-10 kwinqanaba leengqondo ze-2-AG kunye ne-anandamide. ezinye iinguqu eziliqela ingqondo lipid chemistry ziye zabona izilwanyana IDFP kakubi, kuquka ezisezintabeni e ezongezelelweyo N-acylethanolamines (NAEs) [umz: N-palmitoyl- kunye N-oleoylethanolamines kunye monoacylglycerols [2-and 1-palmitoylglycerol kunye 2- kunye 1-oleoylglycerol]. Ngokuthakazelisayo, amanqanaba e-AA ayancipha nge-IDFP kwixabiso elilingana neendawo eziphakanyisiweyo ze-2-AG. Ezi nkcukacha zakha ukuba i-IDFP yindawo ebaluleke kakhulu ye-2-AG kunye ne-anandamide metabolism e-vivo, ekhokelela kumaqondo aphakamileyo kakhulu obuchopho bokuphela kwee-endocannabinoids kunye nokunciphisa okufanayo kumazinga AA wamahhala.
4. IDFP (i-615250-02-7) umlinganiselo
Ukugcinwa kwexesha elide, sincoma ukuba IDFP umthamo zigcinwe njengoko zinikezelwe kwi-20 ℃. Kumele kube nokuzinza okungenani ngonyaka omnye.
I-IDFP inikwe isisombululo kwi-acetate ye-methyl. Ukutshintsha isinyibilikisi, emoyeni nje acetate imethyl phantsi njengomlambo gentle of nitrogenand nangoko ukongeza isinyibilikisi of choice.Solvents ezifana ethanol, DMSO, kunye formamide dimethyl zihlanjululwe yegesi egalelwe zingasetyenziswa. Ukuxiliswa kwe-IDFP kulezi zixazululwazi malunga ne-10mg / ml.
Ukuba izixazululo zesitokisi ezinamandla zifunekayo kwizilingo ze-biological, ziyakulungelelaniswa ngokuhlalutya i-solvent engxenyeni yamanzi okanye i-isotonic saline. Qinisekisa ukuba inani elishiyekileyo le-organicsolvent alibalulekiyo, kuba i-solvents e-organic ingaba nemiphumo yomzimba kwiindawo eziphantsi. ayinakucebisa ukugcina isisombululo esinamandla kwixesha elingaphezu kweyodwa.
I-IDFP (i-615250-02-7) ayikho ekusebenziseni abantu okanye ukusetyenziswa kwezilwanyana, isilumkiso esisaqhubekayo kuphando. Gwema ukunxibelelana ngqo kwesikhumba, amehlo, indlela yokuphefumula, naluphi na ukuphazamiseka, biza ugqirha wakho ngokukhawuleza.
6. I-IDFP (615250-02-7) iimpendulo
I-IDFP (i-615250-02-7) yinkampani ye-organophosphorus enxulumene ne-agent agent ye-sarin. Njenga-sarin, i-IDFP yinto engenakunqandeka ye-inhibitor ngenani lee-enzyme ezahlukeneyo eziqhelekileyo ukukhonza ukuphucula i-neurotransmitters, nangona i-alkyle long chain ye-IDFP yenza ukuba ibuthakathaka ngokuphawulekayo njenge-inhibitor ye-acetylcholinesterase (AChE), ene-IC50 ye-6300nM kuphela, ngelixa i-inhibitor enamandla ezimbini ze-enzymes i-monoacylglycerol lipase (i-MAGL), i-enzyme ephambili ejongene nokuhlaziya i-endocannabinoid 2-arachidonoylglycerol (i-2-AG), kunye ne-fatty acid i-amide hydrolase (FAAH), i-enzyme eyinhloko eyenza enye i-endocannabinoid i-anandamide . I-IC50 ye-IDFP yi-0.8nM kwi-MAGL, kunye ne-3.0nM kwi-FAAH. Ukuvinjelwa kwezi zimbini ze-enzyme kubangela amazinga okwanda okwandisiweyo we-anandamide kunye ne-2-AG ebuchosheni, okubangelwa ukwandiswa kwe-cannabinoid kunye neempembelelo zokuziphatha kwezilwanyana kwizidalwa zezilwanyana, ngelixa ukungabi nako kwamandla kwi-AChE kuthetha ukuba akukho zibonakaliso ze-ACL eziveliswayo. Isakhiwo esifanayo semichiza kwi-agent ye-nerve evinjelweyo, i-alkyle long chain ye-IDFP ibangela ukuba iwele ngaphandle kwencazelo "yeekhemikhali ezinobungozi" phantsi kweMboniselo yeZixhobo zeMichiza, kwaye kungenxa yokuba ingabonakali nentsholongwane ye-AChE inhibition ye-organic organophosphorus, Iingxelo ze-IDFP (615250-02-7) azikho phantsi kolawulo olusemthethweni olufanayo.
tags: bathenge i-IDFP powder, IDFP powder
njeupregatit07 / 18 / 2018 kwi-7: 43
Enkosi!! nethemba lakho le $$ lihamba kakuhle! 🙂 ikhemishi kwi-intanethi
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